diff --git a/browser/matching.py b/browser/matching.py
index 04a9be3..143ae44 100644
--- a/browser/matching.py
+++ b/browser/matching.py
@@ -200,7 +200,7 @@ def _ovid_medline_read_citations(abstract_file_path):
line = line.strip(b"\r\n")
if len(line) == 0:
pass
- elif line[0:1] == b"<" and line[-1:] == b">" and line.strip(b"<").strip(b">").isdecimal():
+ elif line[0:1] == b"<" and line[-1:] == b">" and (line.strip(b"<").strip(b">")).decode("utf-8").isdecimal():
# Starting a new citation, yield if one has already been set up
if citation:
yield citation
diff --git a/tests/abstract-with-html-tags-16-18-16-citation-2.txt b/tests/abstract-with-html-tags-16-18-16-citation-2.txt
new file mode 100644
index 0000000..54058ab
--- /dev/null
+++ b/tests/abstract-with-html-tags-16-18-16-citation-2.txt
@@ -0,0 +1,147350 @@
+<1>
+Unique Identifier
+ 38302990
+Title
+ mini-MED: study protocol for a randomized, multi-intervention, semi-controlled feeding trial of a Mediterranean-amplified vs. habitual Western dietary pattern for the evaluation of food-specific compounds and cardiometabolic health.
+Source
+ Trials [Electronic Resource]. 25(1):101, 2024 Feb 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hill EB; Tang M; Long JM; Kemp JF; Westcott JL; Hendricks AE; Reisdorph NA; Campbell WW; Krebs NF
+Author NameID
+ Hill, Emily B; ORCID: http://orcid.org/0000-0002-0308-5666
+Corporate Author
+ mini-MED Trial Team
+Authors Full Name
+ Hill, Emily B; Tang, Minghua; Long, Julie M; Kemp, Jennifer F; Westcott, Jamie L; Hendricks, Audrey E; Reisdorph, Nichole A; Campbell, Wayne W; Krebs, Nancy F.
+Institution
+ Hill, Emily B. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. emily.b.hill@cuanschutz.edu.
+ Tang, Minghua. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Long, Julie M. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Kemp, Jennifer F. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Westcott, Jamie L. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Hendricks, Audrey E. Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Hendricks, Audrey E. Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO, 80204, USA.
+ Reisdorph, Nichole A. Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Campbell, Wayne W. Department of Nutrition Science, Purdue University, West Lafayette, IN, 47906, USA.
+ Krebs, Nancy F. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Nancy.Krebs@cuanschutz.edu.
+MeSH Subject Headings
+ Animals
+ Cattle
+ Humans
+ Dietary Patterns
+ Obesity/di [Diagnosis]
+ Obesity/pc [Prevention & Control]
+ *Diet, Mediterranean
+ Biomarkers
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Randomized Controlled Trials as Topic
+Keyword Heading
+ Biomarker
+ Diet assessment
+ Foodomics
+ Mediterranean diet
+ Metabolomics
+ Microbiome
+ Nutrimetabolomics
+ Randomized controlled trial
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Diet is among the most influential lifestyle factors impacting chronic disease risk. Nutrimetabolomics, the application of metabolomics to nutrition research, allows for the detection of food-specific compounds (FSCs) that can be used to connect dietary patterns, such as a Mediterranean-style (MED) diet, to health. This validation study is based upon analyses from a controlled feeding MED intervention, where our team identified FSCs from eight foods that can be detected in biospecimens after consumption and may therefore serve as food intake biomarkers.
+
+ METHODS: Individuals with overweight/obesity who do not habitually consume a MED dietary pattern will complete a 16-week randomized, multi-intervention, semi-controlled feeding study of isocaloric dietary interventions: (1) MED-amplified dietary pattern, containing 500 kcal/day from eight MED target foods: avocado, basil, cherry, chickpea, oat, red bell pepper, walnut, and a protein source (alternating between salmon or unprocessed, lean beef), and (2) habitual/Western dietary pattern, containing 500 kcal/day from six non-MED target foods: cheesecake, chocolate frozen yogurt, refined grain bread, sour cream, white potato, and unprocessed, lean beef. After a 2-week washout, participants complete four, 4-week intervention periods, with biospecimen sampling and outcome assessments at baseline and at intervention weeks 4, 8, 12, and 16. The primary outcome is change in the relative abundance of FSCs from the eight MED target foods in participant biospecimens from baseline to the end of each intervention period. Secondary outcomes include mean change in cardiometabolic health indicators, inflammatory markers, and adipokines. Exploratory outcomes include change in diversity and community composition of the gut microbiota.
+
+ DISCUSSION: Our stepwise strategy, beginning with identification of FSCs in whole diets and biospecimens, followed by relating these to health indicators will lead to improved methodology for assessment of dietary patterns and a better understanding of the relationship between food and health. This study will serve as a first step toward validating candidate food intake biomarkers and allow for assessment of relationships with cardiometabolic health. The identification of food intake biomarkers is critical to future research and has implications spanning health promotion and disease prevention for many chronic conditions.
+
+ TRIAL REGISTRATION: Registered at ClinicalTrials.gov: NCT05500976 ; Date of registration: August 15, 2022. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial Protocol. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1186%2fs13063-024-07939-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hill&issn=1745-6215&title=Trials+%5BElectronic+Resource%5D&atitle=mini-MED%3A+study+protocol+for+a+randomized%2C+multi-intervention%2C+semi-controlled+feeding+trial+of+a+Mediterranean-amplified+vs.+habitual+Western+dietary+pattern+for+the+evaluation+of+food-specific+compounds+and+cardiometabolic+health.&volume=25&issue=1&spage=101&epage=&date=2024&doi=10.1186%2Fs13063-024-07939-8&pmid=38302990&sid=OVID:medline
+
+<2>
+Unique Identifier
+ 38195765
+Title
+ Quantitative MRI Biomarkers Measure Changes in Targeted Brain Areas in Patients With Obesity.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 109(7):1850-1857, 2024 Jun 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baynat L; Yamamoto T; Tourdias T; Zhang B; Prevost V; Infante A; Klein A; Caid J; Cadart O; Dousset V; Gatta Cherifi B
+Author NameID
+ Gatta Cherifi, Blandine; ORCID: https://orcid.org/0000-0002-7399-1330
+Authors Full Name
+ Baynat, Louise; Yamamoto, Takayuki; Tourdias, Thomas; Zhang, Bei; Prevost, Valentin; Infante, Asael; Klein, Achille; Caid, Julien; Cadart, Olivier; Dousset, Vincent; Gatta Cherifi, Blandine.
+Institution
+ Baynat, Louise. University of Bordeaux, INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France.
+ Baynat, Louise. CHU Bordeaux, Hopital Haut Leveque Service Endocrinologie, Diabetologie, Nutrition, 33600 Pessac, France.
+ Yamamoto, Takayuki. University of Bordeaux, INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France.
+ Tourdias, Thomas. University of Bordeaux, INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France.
+ Tourdias, Thomas. CHU Bordeaux, Hopital Pellegrin, Service de Neuroimagerie diagnostique et therapeutique, 33000 Bordeaux, France.
+ Zhang, Bei. Magnetic Resonance, Canon Medical Systems Europe, 2718 Zoetermeer, Netherlands.
+ Prevost, Valentin. CT-MR Solution Planning Department, Canon Medical Systems Corporation, Tochigi, Japan.
+ Infante, Asael. CHU Bordeaux, Hopital Haut Leveque Service Endocrinologie, Diabetologie, Nutrition, 33600 Pessac, France.
+ Klein, Achille. CHU Bordeaux, Hopital Haut Leveque Service Endocrinologie, Diabetologie, Nutrition, 33600 Pessac, France.
+ Caid, Julien. CHU Bordeaux, Hopital Haut Leveque Service Endocrinologie, Diabetologie, Nutrition, 33600 Pessac, France.
+ Cadart, Olivier. Endocrinology, Centre Hospitalier d'Angouleme, Endocrinolology, Rond point Girac, 16000 Angouleme, France.
+ Dousset, Vincent. University of Bordeaux, INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France.
+ Dousset, Vincent. CHU Bordeaux, Hopital Pellegrin, Service de Neuroimagerie diagnostique et therapeutique, 33000 Bordeaux, France.
+ Gatta Cherifi, Blandine. University of Bordeaux, INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France.
+ Gatta Cherifi, Blandine. CHU Bordeaux, Hopital Haut Leveque Service Endocrinologie, Diabetologie, Nutrition, 33600 Pessac, France.
+MeSH Subject Headings
+ Humans
+ Female
+ Male
+ Obesity/me [Metabolism]
+ Obesity/dg [Diagnostic Imaging]
+ *Obesity
+ Magnetic Resonance Imaging/mt [Methods]
+ *Magnetic Resonance Imaging
+ Adult
+ Prospective Studies
+ Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ *Biomarkers
+ Middle Aged
+ Brain/dg [Diagnostic Imaging]
+ Brain/me [Metabolism]
+ Brain/pa [Pathology]
+ *Brain
+ Hippocampus/dg [Diagnostic Imaging]
+ Hippocampus/me [Metabolism]
+ Hippocampus/pa [Pathology]
+ Case-Control Studies
+ Hypothalamus/dg [Diagnostic Imaging]
+ Hypothalamus/me [Metabolism]
+ Hypothalamus/pa [Pathology]
+Keyword Heading
+ hippocampus
+ hypothalamus
+ neuroinflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Obesity is accompanied by damages to several tissues, including the brain. Pathological data and animal models have demonstrated an increased inflammatory reaction in hypothalamus and hippocampus.
+
+ OBJECTIVE: We tested whether we could observe such pathological modifications in vivo through quantitative magnetic resonance imaging (MRI) metrics.
+
+ METHODS: This prospective study was conducted between May 2019 and November 2022. The study was conducted in the Specialized Center for the Care of Obesity in a French University Hospital. Twenty-seven patients with obesity and 23 age and gender-paired normal-weight controls were prospectively recruited. All participants were examined using brain MRI. Anthropometric and biological data, eating behavior, anxiety, depression, and memory performance were assessed in both groups. The main outcome measure was brain MRI with the following parametric maps: quantitative susceptibility mapping (QSM), mean diffusivity (MD), fractional anisotropy (FA), magnetization transfer ratio map, and T2 relaxivity map.
+
+ RESULTS: In the hypothalamus, patients with obesity had higher FA and lower QSM than normal-weight controls. In the hippocampus, patients with obesity had higher FA and lower MD. There was no correlation between imaging biomarkers and eating behavior or anxiety.
+
+ CONCLUSION: Our findings are consistent with the presence of neuroinflammation in brain regions involved in food intake. In vivo brain biomarkers from quantitative MRI appear to provide an incremental information for the assessment of brain damages in patients with obesity. Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1210%2fclinem%2fdgae014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baynat&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Quantitative+MRI+Biomarkers+Measure+Changes+in+Targeted+Brain+Areas+in+Patients+With+Obesity.&volume=109&issue=7&spage=1850&epage=1857&date=2024&doi=10.1210%2Fclinem%2Fdgae014&pmid=38195765&sid=OVID:medline
+
+<3>
+Unique Identifier
+ 38735470
+Title
+ Alterations in salivary biomarkers in relation to periodontal health and obesity among Hong Kong adolescents.
+Source
+ Journal of Dentistry. 146:105055, 2024 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Deng Q; Wong HM; Peng S
+Authors Full Name
+ Deng, Qianyi; Wong, Hai Ming; Peng, Simin.
+Institution
+ Deng, Qianyi. Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, PR China.
+ Wong, Hai Ming. Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China.
+ Peng, Simin. Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China. Electronic address: pengsm@hku.hk.
+MeSH Subject Headings
+ Humans
+ Saliva/ch [Chemistry]
+ *Saliva
+ Adolescent
+ Biomarkers/an [Analysis]
+ *Biomarkers
+ Female
+ Male
+ Hong Kong
+ Interleukin-6/an [Analysis]
+ *Interleukin-6
+ Child
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Periodontitis/me [Metabolism]
+ Bacterial Load
+ Waist-Height Ratio
+ Adiposity
+ Oral Health
+ Periodontal Index
+Keyword Heading
+ Abdominal obesity
+ Interleukin-6
+ Paediatric obesity
+ Periodontal diseases
+ Phospholipases A2
+ Saliva
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To explore the association among salivary biomarkers, periodontal inflammation, and adiposity status in adolescents.
+
+ METHODS: This study included 180 Hong Kong adolescents aged 12-15 years. Anthropometric measurements including central obesity surrogate, waist-to-height ratio (WHtR), and dental examinations were conducted. The participants were classified into four groups as follows: with normal WHtR and less extensive periodontal inflammation (NW+LP); with high WHtR and less extensive periodontal inflammation (HW+LP); with normal WHtR and more extensive periodontal inflammation (NW+P); and with high WHtR and more extensive periodontal inflammation (HW+P). Saliva were collected to measure salivary physicochemical parameters, total bacterial load, and levels of protein biomarkers including secretory phospholipase A2 group IIA (sPLA2-IIA) and interleukin-6 (IL-6). Data were analysed by Kruskal-Wallis test and Spearman correlation coefficient.
+
+ RESULTS: Salivary IL-6 levels and sPLA2-IIA and IL-6 output differed significantly between groups (P = 0.041, 0.027, and 0.043, respectively). The NW+P group had significantly higher salivary IL-6 output than the NW+LP group (P = 0.034) and significantly lower salivary sPLA2-IIA output than the HW+LP group (P = 0.038). Salivary IL-6 levels were negatively correlated with the number of sextants with healthy gingivae and positively correlated with salivary sPLA2-IIA levels in participants with normal WHtR. Salivary sPLA2-IIA levels were negatively correlated with total salivary bacterial load in participants with high WHtR.
+
+ CONCLUSIONS: Salivary IL-6 levels were associated with the extent of periodontal inflammation in participants with normal WHtR but not in those with high WHtR. Adolescents with different adiposity status may have different mechanisms of periodontal inflammation.
+
+ CLINICAL SIGNIFICANCE: Investigating salivary biomarkers of periodontal health holds potential benefits in identifying individuals at risk and customizing oral health promotion strategies for individuals with varying levels of adiposity, even as early as adolescence. Copyright © 2024. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1016%2fj.jdent.2024.105055
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Deng&issn=0300-5712&title=Journal+of+Dentistry&atitle=Alterations+in+salivary+biomarkers+in+relation+to+periodontal+health+and+obesity+among+Hong+Kong+adolescents.&volume=146&issue=&spage=105055&epage=&date=2024&doi=10.1016%2Fj.jdent.2024.105055&pmid=38735470&sid=OVID:medline
+
+<4>
+Unique Identifier
+ 38677250
+Title
+ High adherence to the French dietary guidelines decreases type 2 diabetes risk in females through pathways of obesity markers: Evidence from the E3N-EPIC prospective cohort study.
+Source
+ Nutrition. 124:112448, 2024 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Seck D; Shah S; Correia E; Marques C; Varraso R; Gaye B; Boutron-Ruault MC; Laouali N
+Authors Full Name
+ Seck, Daouda; Shah, Sanam; Correia, Emmanuelle; Marques, Chloe; Varraso, Raphaelle; Gaye, Bamba; Boutron-Ruault, Marie-Christine; Laouali, Nasser.
+Institution
+ Seck, Daouda. Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, F-94805, Villejuif, France.
+ Shah, Sanam. Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, F-94805, Villejuif, France.
+ Correia, Emmanuelle. Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, F-94805, Villejuif, France.
+ Marques, Chloe. Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, F-94805, Villejuif, France.
+ Varraso, Raphaelle. Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Integrative Respiratory Epidemiology'' team, CESP, F-94805, Villejuif, France.
+ Gaye, Bamba. INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.
+ Boutron-Ruault, Marie-Christine. Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, F-94805, Villejuif, France.
+ Laouali, Nasser. Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, F-94805, Villejuif, France; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA; Scripps Institution of Oceanography, University of California, San Diego, California, USA; Institute of Biological Sciences (ISSB), UM6P Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben Guerir, Morocco. Electronic address: nasser.laouali@um6p.ma.
+MeSH Subject Headings
+ Humans
+ Female
+ Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ *Diabetes Mellitus, Type 2
+ Middle Aged
+ France/ep [Epidemiology]
+ Prospective Studies
+ *Obesity
+ *Nutrition Policy
+ *Body Mass Index
+ Risk Factors
+ Adult
+ Waist-Hip Ratio
+ Biomarkers/bl [Blood]
+ Cohort Studies
+ Proportional Hazards Models
+Keyword Heading
+ Obesity, France, Cohort study, Mediation
+ sPNNS-GS2, PNNS, Dietary patterns, Type 2 Diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Obesity and type 2 diabetes (T2D) have been associated with low adherence to the 2017 French food-based dietary guidelines, as assessed by the Programme National Nutrition Sante - guidelines score 2 (PNNS-GS2). Whether the association between T2D and PNNS-GS2 is direct or mediated by obesity has been little investigated.
+
+ RESEARCH METHODS: The study included 71,450 women from the E3N-EPIC cohort, mean age of 52.9 y (SD 6.7). The simplified PNNS-GS2 was derived via food history questionnaire. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of T2D. Causal mediation analyses were used to decompose the total effect of sPNNS-GS2 on T2D into a direct effect and indirect effect mediated by body mass index (BMI) or the waist-hip ratio (WHR).
+
+ RESULTS: During a mean follow-up of 19 y, 3679 incident T2D cases were identified and validated. There was a linear association between adherence to sPNNS-GS2 and T2D (P-nonlinearity = 0.92). In the fully adjusted model, each 1-SD increase in the sPNNS-GS2 was associated with a lower T2D risk [HR (95% CI), 0.92 (0.89, 0.95)]. The overall associations were mainly explained by sPNNS-GS2-associated excess weight, with BMI and WHR mediating 52% and 58% of the associations, respectively.
+
+ CONCLUSIONS: Higher adherence to French food-based dietary guidelines was associated with a lower risk of T2D in women, and a significant portion of this effect could be attributed to excess weight measured by BMI or WHR. This finding helps better understand the mechanisms underlying the diet-T2D association. Copyright © 2024 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1016%2fj.nut.2024.112448
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Seck&issn=0899-9007&title=Nutrition&atitle=High+adherence+to+the+French+dietary+guidelines+decreases+type+2+diabetes+risk+in+females+through+pathways+of+obesity+markers%3A+Evidence+from+the+E3N-EPIC+prospective+cohort+study.&volume=124&issue=&spage=112448&epage=&date=2024&doi=10.1016%2Fj.nut.2024.112448&pmid=38677250&sid=OVID:medline
+
+<5>
+Unique Identifier
+ 38584010
+Title
+ Comparative efficacy of different exercise types on inflammatory markers in women with overweight and obesity: A systematic review and network meta-analysis of randomized controlled trials. [Review]
+Source
+ Journal of Science & Medicine in Sport. 27(7):458-465, 2024 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tan L; Yan W; Zhang B; Zhao Z; Lipowski M; Ossowski Z
+Authors Full Name
+ Tan, Liang; Yan, Weihua; Zhang, Bo; Zhao, Zijian; Lipowski, Mariusz; Ossowski, Zbigniew.
+Institution
+ Tan, Liang. Faculty of Physical Culture, Gdansk University of Physical Education and Sport, Poland; Changsha College of Commerce and Tourism, China. Electronic address: liang.tan@awf.gda.pl.
+ Yan, Weihua. School of Management, Beijing Sport University, China. Electronic address: 2019112011@bsu.edu.cn.
+ Zhang, Bo. China Football College, Beijing Sport University, China. Electronic address: zhangbo@zgbqxhqsnfzwy.wecom.work.
+ Zhao, Zijian. Physical Education Institute (Main Campus), Zhengzhou University, China. Electronic address: zjzhao@zzu.edu.cn.
+ Lipowski, Mariusz. Faculty of Social and Humanities, University WSB Merito, Poland. Electronic address: mariusz.lipowski@gdansk.merito.pl.
+ Ossowski, Zbigniew. Faculty of Physical Culture, Gdansk University of Physical Education and Sport, Poland. Electronic address: zbigniew.ossowski@awf.gda.pl.
+MeSH Subject Headings
+ Humans
+ Female
+ *Randomized Controlled Trials as Topic
+ Obesity/bl [Blood]
+ Obesity/th [Therapy]
+ *Obesity
+ *Resistance Training
+ *Network Meta-Analysis
+ *Exercise
+ Overweight/th [Therapy]
+ Overweight/bl [Blood]
+ *Overweight
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ C-Reactive Protein/an [Analysis]
+ Tumor Necrosis Factor-alpha/bl [Blood]
+ Interleukin-6/bl [Blood]
+ High-Intensity Interval Training
+ Leptin/bl [Blood]
+ Adiponectin/bl [Blood]
+ Inflammation/bl [Blood]
+Keyword Heading
+ Exercise types
+ Inflammatory
+ Network meta-analysis
+ Women with overweight and obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: This study aimed to compare and rank the effectiveness of aerobic exercise, resistance training, combined aerobic and resistance exercise, and high-intensity interval training on inflammatory marker levels in women with overweight and obesity by using network meta-analysis.
+
+ DESIGN: Systematic review with network meta-analysis and Grading Recommendations Assessment, Development, and Evaluation of the evidence.
+
+ METHODS: Literature as of April 2023 was searched from databases such as Cochrane, Embase, Pubmed, Web of Science, and EBSCO, and English-language randomized controlled trials that meet the inclusion criteria were selected. A random-effects network meta-analysis was performed within a frequentist framework.
+
+ RESULTS: A total of 75 articles and 4048 participants were included. Resistance training was the most recommended type of exercise to decrease C-reactive protein levels (surface under cumulative ranking=90.1; standardized mean difference=-0.79, 95% confidence interval: -1.17, -0.42); aerobic exercise was the most effective exercise type to reduce tumor necrosis factor-alpha levels (surface under cumulative ranking=87.9; standardized mean difference=-0.79, 95% confidence interval: -1.19, -0.39); combined aerobic and resistance exercise was the most effective type of exercise to reduce interleukin-6 levels (surface under cumulative ranking=75.8; standardized mean difference=-0.77, 95% confidence interval: -1.38, -0.16) and leptin levels (surface under cumulative ranking=77.1; standardized mean difference=-0.96, 95% confidence interval: -1.72, -0.20), and high-intensity interval training was the type of exercise that was well suited to increase adiponectin levels (surface under cumulative ranking=87.2; standardized mean difference=0.99, 95% confidence interval: 0.27, 1.71).
+
+ CONCLUSIONS: This network meta-analysis based on randomized controlled trials confirmed that different exercise types have different efficacies on inflammation indicators among women with overweight and obesity. The findings may provide clinicians and healthcare professionals with insights into the implementation of exercise programs for women struggling with overweight and obesity. Copyright © 2024 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). 0 (Tumor Necrosis Factor-alpha). 0 (Interleukin-6). 0 (Leptin). 0 (Adiponectin).
+Publication Type
+ Journal Article. Systematic Review. Meta-Analysis. Comparative Study. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1016%2fj.jsams.2024.03.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tan&issn=1878-1861&title=Journal+of+Science+%26+Medicine+in+Sport&atitle=Comparative+efficacy+of+different+exercise+types+on+inflammatory+markers+in+women+with+overweight+and+obesity%3A+A+systematic+review+and+network+meta-analysis+of+randomized+controlled+trials.&volume=27&issue=7&spage=458&epage=465&date=2024&doi=10.1016%2Fj.jsams.2024.03.007&pmid=38584010&sid=OVID:medline
+
+<6>
+Unique Identifier
+ 38663803
+Title
+ Growth differentiation factor-15 and metabolic features in chronic heart failure: Insights from the SUPPORT Trial -GDF15 across the BMI spectrum.
+Source
+ International Journal of Cardiology. 407:132093, 2024 Jul 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Teramoto K; Nochioka K; Sakata Y; Kato ET; Nishimura K; Shimokawa H; Yasuda S
+Corporate Author
+ SUPPORT Trial Investigators
+Authors Full Name
+ Teramoto, Kanako; Nochioka, Kotaro; Sakata, Yasuhiko; Kato, Eri Toda; Nishimura, Kunihiro; Shimokawa, Hiroaki; Yasuda, Satoshi.
+Institution
+ Teramoto, Kanako. Department of Biostatistics, National Cerebral and Cardiovascular Center, Osaka, Japan.
+ Nochioka, Kotaro. Division of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: nochioka@cardio.med.tohoku.ac.jp.
+ Sakata, Yasuhiko. Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Osaka, Japan.
+ Kato, Eri Toda. Department of Cardiovascular Medicine and Department of Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan.
+ Nishimura, Kunihiro. Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
+ Shimokawa, Hiroaki. Division of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; International University of Health and Welfare Graduate School, Narita, Japan.
+ Yasuda, Satoshi. Division of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
+MeSH Subject Headings
+ Humans
+ Growth Differentiation Factor 15/bl [Blood]
+ *Growth Differentiation Factor 15
+ Heart Failure/bl [Blood]
+ Heart Failure/ep [Epidemiology]
+ *Heart Failure
+ Female
+ Male
+ Aged
+ Middle Aged
+ *Body Mass Index
+ Chronic Disease
+ Biomarkers/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Follow-Up Studies
+ Thinness/bl [Blood]
+ Thinness/ep [Epidemiology]
+Keyword Heading
+ Cachexia
+ Chronic heart failure
+ Growth differentiation factor-15
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: GDF15 plays pivotal metabolic roles in nutritional stress and serves as a physiological regulator of energy balance. However, the patterns of GDF15 levels in underweight or obese patients with chronic heart failure (CHF) are not well-understood.
+
+ METHODS: We assessed serum GDF15 levels at baseline and 3 years and the temporal changes in 940 Japanese patients (642 paired samples), as a sub-analysis of the SUPPORT trial (age 65.9 +/- 10.1 years). The GDF15 levels were analyzed across BMI groups (underweight [<18.5 kg/m2; n = 50], healthy weight [18.5-22.9; n = 27 5], overweight [23-24.9; n = 234], and obese [>=25; n = 381]), following WHO recommendations for the Asian-Pacific population. Landmark analysis at 3 years assessed the association between GDF15 levels and HF hospitalization or all-cause death.
+
+ RESULTS: Compared to the healthy weight group, the underweight group included more females (54.0%) with advanced HF (NYHA class III; 20.0%) and exhibited increased GDF15 level (1764 pg/mL [IQR 1067-2633]). Obese patients, younger (64.2 years) and diabetic (53%), had a similar GDF15 level to the healthy weight group. A higher baseline GDF15 level was associated with worse outcomes across the BMI spectrum. GDF15 increased by 208 [21-596] pg/mL over 3 years, with the most substantial increase observed in the underweight group (by +28.9% [6.2-81.0]). Persistently high GDF15 levels (>=1800 pg/mL) was independently associated with worse outcomes after 3 years (adjusted HR 1.8 [95%CI 1.1-2.9]).
+
+ CONCLUSIONS: In underweight patients with CHF, GDF15 level was elevated at baseline and experienced the most significant increase over 3 years. Its consistent elevation suggested a worse outcome. Copyright © 2023. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (GDF15 protein, human).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Multicenter Study.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1016%2fj.ijcard.2024.132093
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Teramoto&issn=0167-5273&title=International+Journal+of+Cardiology&atitle=Growth+differentiation+factor-15+and+metabolic+features+in+chronic+heart+failure%3A+Insights+from+the+SUPPORT+Trial+-GDF15+across+the+BMI+spectrum.&volume=407&issue=&spage=132093&epage=&date=2024&doi=10.1016%2Fj.ijcard.2024.132093&pmid=38663803&sid=OVID:medline
+
+<7>
+Unique Identifier
+ 38590187
+Title
+ Adipose-derived miRNAs as potential biomarkers for predicting adulthood obesity and its complications: A systematic review and bioinformatic analysis. [Review]
+Source
+ Obesity Reviews. 25(7):e13748, 2024 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu X; Sun H; Zheng L; Zhang J; Su H; Li B; Wu Q; Liu Y; Xu Y; Song X; Yu Y
+Author NameID
+ Yu, Yang; ORCID: https://orcid.org/0000-0002-2480-7306
+Authors Full Name
+ Liu, Xiyan; Sun, Huayi; Zheng, Lixia; Zhang, Jian; Su, Han; Li, Bingjie; Wu, Qianhui; Liu, Yunchan; Xu, Yingxi; Song, Xiaoyu; Yu, Yang.
+Institution
+ Liu, Xiyan. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Liu, Xiyan. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Sun, Huayi. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Sun, Huayi. Department of Colorectal Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
+ Zheng, Lixia. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Zheng, Lixia. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Zhang, Jian. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Zhang, Jian. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+ Su, Han. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Su, Han. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Li, Bingjie. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Li, Bingjie. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+ Wu, Qianhui. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Wu, Qianhui. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+ Liu, Yunchan. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Liu, Yunchan. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+ Xu, Yingxi. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Xu, Yingxi. Department of Clinical Nutrition, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
+ Song, Xiaoyu. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Song, Xiaoyu. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Yu, Yang. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Yu, Yang. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Yu, Yang. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+MeSH Subject Headings
+ Humans
+ Obesity/ge [Genetics]
+ Obesity/co [Complications]
+ *Obesity
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ *Computational Biology
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ *Biomarkers
+Keyword Heading
+ adipose tissue
+ circulating miRNAs
+ comorbidity
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipose tissue is the first and primary target organ of obesity and the main source of circulating miRNAs in patients with obesity. This systematic review aimed to analyze and summarize the generation and mechanisms of adipose-derived miRNAs and their role as early predictors of various obesity-related complications. Literature searches in the PubMed and Web of Science databases using terms related to miRNAs, obesity, and adipose tissue. Pre-miRNAs from the Human MicroRNA Disease Database, known to regulate obesity-related metabolic disorders, were combined for intersection processing. Validated miRNA targets were sorted through literature review, and enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes via the KOBAS online tool, disease analysis, and miRNA transcription factor prediction using the TransmiR v. 2.0 database were also performed. Thirty miRNAs were identified using both obesity and adipose secretion as criteria. Seventy-nine functionally validated targets associated with 30 comorbidities of these miRNAs were identified, implicating pathways such as autophagy, p53 pathways, and inflammation. The miRNA precursors were analyzed to predict their transcription factors and explore their biosynthesis mechanisms. Our findings offer potential insights into the epigenetic changes related to adipose-driven obesity-related comorbidities. Copyright © 2024 World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (MicroRNAs). 0 (Biomarkers).
+Publication Type
+ Systematic Review. Journal Article. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1111%2fobr.13748
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=1467-7881&title=Obesity+Reviews&atitle=Adipose-derived+miRNAs+as+potential+biomarkers+for+predicting+adulthood+obesity+and+its+complications%3A+A+systematic+review+and+bioinformatic+analysis.&volume=25&issue=7&spage=e13748&epage=&date=2024&doi=10.1111%2Fobr.13748&pmid=38590187&sid=OVID:medline
+
+<8>
+Unique Identifier
+ 38574322
+Title
+ Diagnostic Performance of Insulin Resistance Indices for Identifying Metabolic Dysfunction-Associated Fatty Liver Disease.
+Source
+ Metabolic Syndrome & Related Disorders. 22(5):402-409, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Han AL; Lee HK; Shin SR
+Author NameID
+ Han, A Lum; ORCID: https://orcid.org/0000-0002-6509-7953
+Authors Full Name
+ Han, A Lum; Lee, Hee Kyung; Shin, Sae Ron.
+Institution
+ Han, A Lum. Department of Family Medicine, Wonkwang University Hospital, Iksan, Korea.
+ Lee, Hee Kyung. Department of Family Medicine, Wonkwang University Hospital, Iksan, Korea.
+ Shin, Sae Ron. Department of Family Medicine, Wonkwang University Hospital, Iksan, Korea.
+MeSH Subject Headings
+ Humans
+ *Insulin Resistance
+ Male
+ Female
+ Middle Aged
+ Retrospective Studies
+ Adult
+ *Body Mass Index
+ Blood Glucose/an [Analysis]
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose
+ Triglycerides/bl [Blood]
+ *Triglycerides
+ *Tomography, X-Ray Computed
+ Waist Circumference
+ Aged
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Biomarkers/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Fatty Liver/di [Diagnosis]
+ Fatty Liver/bl [Blood]
+ ROC Curve
+Keyword Heading
+ computed tomography
+ diagnostic performance
+ insulin resistance
+ metabolic dysfunction-associated fatty liver disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background/objectives: Insulin resistance (IR) plays an important role in metabolic dysfunction-associated fatty liver disease (MAFLD) pathogenesis. A modified triglyceride-glucose (TyG) index, including TyG-body mass index (TyG-BMI) and TyG-waist circumference (TyG-WC), has been introduced to represent IR. This study aimed to investigate the diagnostic abilities of IR indices in MAFLD, in which fatty liver was diagnosed using computed tomography (CT). Subjects/methods: We retrospectively analyzed the clinical data and images of 852 adults aged >=19 years who underwent abdominal CT. MAFLD was diagnosed based on the appearance of fatty liver on CT alongside at least one of the following three criteria: being overweight or obese, at least two metabolic risk abnormalities, and/or diabetes mellitus. IR indices were calculated by examining the following variables: homeostasis model assessment-IR, TyG index, TyG-BMI, TyG-WC, and visceral adiposity index. The diagnostic accuracy was evaluated using the area under the receiver operating characteristic curve. Results: For all patients, the area under the curve (AUC) of the TyG index, TyG-BMI, and TyG-WC were 0.834, 0.938, and 0.942, respectively. In men, the AUC of the TyG index, TyG-BMI, and TyG-WC were 0.812, 0.928, and 0.934, respectively. In women, the AUC of the TyG index was 0.841, and TyG-BMI and TyG-WC were 0.940 and 0.953, respectively. The AUC values tended to increase in the following order: TyG index < TyG-BMI < TyG-WC. Women showed a higher AUC than men in all items, and the TyG-WC of women showed the highest value with AUC 0.953 (95% confidence interval [CI]: 0.892-1.000, P < 0.0001). The AUC of the TyG index was 0.858 (95% CI: 0.828-0.888, P < 0.0001). Conclusions: In conclusion, TyG-WC is a powerful surrogate marker for identifying MAFLD in clinical settings.
+Registry Number/Name of Substance
+ 0 (Blood Glucose). 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1089%2fmet.2023.0276
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Han&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Diagnostic+Performance+of+Insulin+Resistance+Indices+for+Identifying+Metabolic+Dysfunction-Associated+Fatty+Liver+Disease.&volume=22&issue=5&spage=402&epage=409&date=2024&doi=10.1089%2Fmet.2023.0276&pmid=38574322&sid=OVID:medline
+
+<9>
+Unique Identifier
+ 38395746
+Title
+ Label-Free Electrochemical Immunosensor Based on Conjugated Polymer Film Coated Disposable Electrode for Ultrasensitive Determination of Resistin Potential Obesity Biomarker.
+Source
+ Acs Applied Bio Materials. 7(3):1820-1830, 2024 03 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aydin EB; Aydin M; Sezginturk MK
+Authors Full Name
+ Aydin, Elif Burcu; Aydin, Muhammet; Sezginturk, Mustafa Kemal.
+Institution
+ Aydin, Elif Burcu. Scientific and Technological Research Center, Tekirdag Namik Kemal University, Tekirdag, Turkey 59030.
+ Aydin, Muhammet. Scientific and Technological Research Center, Tekirdag Namik Kemal University, Tekirdag, Turkey 59030.
+ Sezginturk, Mustafa Kemal. Bioengineering Department, Faculty of Engineering, Canakkale Onsekiz Mart University, Canakkale, Turkey 17100.
+MeSH Subject Headings
+ Humans
+ *Resistin
+ *Biosensing Techniques
+ Immunoassay
+ Reproducibility of Results
+ Biomarkers
+ Electrodes
+ Obesity/di [Diagnosis]
+ Polymers
+Keyword Heading
+ conducting thiophene polymer
+ disposable biosensor
+ obesity biomarker
+ resistin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ A new label-free immunosensor was designed for sensitive detection of resistin obesity biomarker in human biological fluids. To construct a sensing interface, the monomer of double epoxy groups-substituted thiophene (TdiEpx) was synthesized for the fabrication of the biosensing system. A disposable indium tin oxide sheet was first modified by electrochemical polymerization of the TdiEpx monomer, and this robust and novel surface was characterized using different spectroscopic and electrochemical analyses. The double epoxy ends were linked to the amino ends of anti-resistin, and they served as binding points for the covalent binding of biomolecules. The double epoxy ends present in each TdiEpx monomer ensured an extensive surface area, which improved the quantity of attached anti-resistin. The determination of resistin antigen was based on the specific coupling of resistin with anti-resistin, and this interaction hindered the electron transfer reaction. The immunosensor introduced a wide linear range of 0.0125-15 pg/mL, a low detection limit of 4.17 fg/mL, and an excellent sensitivity of 1.38 kohm pg mL-1 cm2. In this study, a sandwich enzyme-linked immunosorbent assay spectrophotometric method was utilized as a reference technique for the quantitative analysis of resistin in human serum and saliva samples. Both measurements in clinical samples displayed correlations and high-correlation coefficients. In addition, this immunosensor had good storage stability, acceptable repeatability and reproducibility, high specificity, and good accuracy. The proposed immunosensor provided a simple and versatile impedimetric immunosensing platform and a promisingly sensitive way for clinical applications.
+Registry Number/Name of Substance
+ 0 (Resistin). 0 (Biomarkers). 0 (Polymers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1021%2facsabm.3c01231
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aydin&issn=2576-6422&title=Acs+Applied+Bio+Materials&atitle=Label-Free+Electrochemical+Immunosensor+Based+on+Conjugated+Polymer+Film+Coated+Disposable+Electrode+for+Ultrasensitive+Determination+of+Resistin+Potential+Obesity+Biomarker.&volume=7&issue=3&spage=1820&epage=1830&date=2024&doi=10.1021%2Facsabm.3c01231&pmid=38395746&sid=OVID:medline
+
+<10>
+Unique Identifier
+ 38553359
+Title
+ Moderate-intensity constant or high-intensity interval training? Metabolic effects on candidates to undergo bariatric surgery.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 34(7):1681-1691, 2024 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Enriquez-Schmidt J; Mautner Molina C; Kalazich Rosales M; Munoz M; Ruiz-Uribe M; Fuentes Leal F; Monrroy Uarac M; Carcamo Ibaceta C; Fazakerley DJ; Larance M; Ehrenfeld P; Martinez-Huenchullan S
+Authors Full Name
+ Enriquez-Schmidt, Javier; Mautner Molina, Camila; Kalazich Rosales, Mariana; Munoz, Maximiliano; Ruiz-Uribe, Matias; Fuentes Leal, Francisca; Monrroy Uarac, Manuel; Carcamo Ibaceta, Carlos; Fazakerley, Daniel J; Larance, Mark; Ehrenfeld, Pamela; Martinez-Huenchullan, Sergio.
+Institution
+ Enriquez-Schmidt, Javier. Physical Therapy Unit, Locomotor Apparatus and Rehabilitation Institute, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile; Exercise Physiology Laboratory, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.
+ Mautner Molina, Camila. Clinica Alemana de Valdivia, Valdivia 5090000, Chile; School of Physical Therapy, Universidad San Sebastian, Valdivia 5090000, Chile.
+ Kalazich Rosales, Mariana. Clinica Alemana de Valdivia, Valdivia 5090000, Chile.
+ Munoz, Maximiliano. Clinica Alemana de Valdivia, Valdivia 5090000, Chile.
+ Ruiz-Uribe, Matias. Cardiorespiratory and Metabolic Function Laboratory - Neyun, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile; Nephrology Division, School of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile.
+ Fuentes Leal, Francisca. Clinica Alemana de Valdivia, Valdivia 5090000, Chile.
+ Monrroy Uarac, Manuel. Physical Therapy Unit, Locomotor Apparatus and Rehabilitation Institute, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile; Exercise Physiology Laboratory, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.
+ Carcamo Ibaceta, Carlos. Clinica Alemana de Valdivia, Valdivia 5090000, Chile; Surgery Institute, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile.
+ Fazakerley, Daniel J. Metabolic Research Laboratory, Wellcome-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB5, United Kingdom.
+ Larance, Mark. Charles Perkins Centre and School of Medical Sciences, The University of Sydney, Sydney 2006, Australia.
+ Ehrenfeld, Pamela. Cellular Pathology Laboratory, Anatomy, Histology, and Pathology Institute, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile; Centro Interdisciplinario de Estudios del Sistema Nervioso (CISNe), Universidad Austral de Chile, Valdivia 5090000, Chile.
+ Martinez-Huenchullan, Sergio. Physical Therapy Unit, Locomotor Apparatus and Rehabilitation Institute, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile; School of Physical Therapy, Universidad San Sebastian, Valdivia 5090000, Chile; Cardiorespiratory and Metabolic Function Laboratory - Neyun, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile; Nephrology Division, School of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile; Centro Interdisciplinario de Estudios del Sistema Nervioso (CISNe), Universidad Austral de Chile, Valdivia 5090000, Chile. Electronic address: sergio.martinez@uss.cl.
+MeSH Subject Headings
+ Humans
+ Female
+ Male
+ *High-Intensity Interval Training
+ Middle Aged
+ Adult
+ Treatment Outcome
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Time Factors
+ Young Adult
+ Gastrectomy/ae [Adverse Effects]
+ *Gastrectomy
+ *Weight Loss
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose
+ Adolescent
+ Bariatric Surgery
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Obesity/su [Surgery]
+ Obesity/pp [Physiopathology]
+ Obesity/bl [Blood]
+Keyword Heading
+ Bariatric surgery
+ Exercise
+ Glycaemic control
+ Insulin sensitivity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: Bariatric surgery is highly effective against obesity. Pre-surgical exercise programs are recommended to prepare the candidate physically and metabolically for surgery-related rapid weight loss. However, the ideal exercise prescription in this population is unknown. This study aimed to compare the metabolic effects of moderate-intensity constant (MICT) vs. a high-intensity interval training (HIIT) program in candidates to undergo bariatric surgery.
+
+ METHODS AND RESULTS: Twenty-five candidates (22 women) to undergo sleeve gastrectomy aged from 18 to 60 years old were recruited. At baseline, we measured body composition, physical activity levels, grip strength, and aerobic capacity. Further, we assessed metabolic function through glycemia and insulinemia (both fasting and after oral glucose tolerance test (OGTT)), homeostatic model assessment for insulin resistance (HOMA-IR), lipid profile, glycated haemoglobin (HbA1c), transaminases, fibroblast growth factor 21 (FGF21), growth differentiation factor 15 (GDF15), apelin, and adiponectin. Afterward, participants were randomized into MICT (n = 14) or HIIT (n = 11). Both training programs consisted of 10 sessions (2-3 times/week, 30 min per session) distributed during 4 weeks before the surgery. After this, all outcomes were measured again at the end of the training programs and 1 month after the surgery (follow-up). A mixed effect with Tukey's post-hoc analysis was performed to compare values at baseline vs. post-training vs. postsurgical follow-up. Both training programs increased aerobic capacity after training (p < 0.05), but only after MICT these changes were kept at follow-up (p < 0.05). However, only MICT decreased fat mass and increased total muscle mass and physical activity levels (p < 0.05). Metabolically, MICT decreased insulinemia after OGTT (p < 0.05), whereas HIIT increased adiponectin after training and GDF15 at follow-up (both p < 0.05).
+
+ CONCLUSIONS: Both MICT and HIIT conferred benefits in candidates to undergo bariatric surgery, however, several of those effects were program-specific, suggesting that exercise intensity should be considered when preparing these patients. Future studies should explore the potential benefits of prescribing MICT or HIIT in a customized fashion depending on a pretraining screening, along with possible summatory effects by combining these two exercise programs (MICT + HIIT).
+
+ CLINICAL TRIAL REGISTRATION: International Traditional Medicine Clinical Trial Registry, Ndegree ISRCTN42273422. Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Comparative Study.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1016%2fj.numecd.2024.03.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Enriquez-Schmidt&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Moderate-intensity+constant+or+high-intensity+interval+training%3F+Metabolic+effects+on+candidates+to+undergo+bariatric+surgery.&volume=34&issue=7&spage=1681&epage=1691&date=2024&doi=10.1016%2Fj.numecd.2024.03.001&pmid=38553359&sid=OVID:medline
+
+<11>
+Unique Identifier
+ 38788255
+Title
+ Study of non-alcoholic fatty pancreatic disease among the Egyptian population and the value of serum fatty acid binding protein-1 (FABP-1) as a non-invasive biomarker.
+Source
+ Clinics & Research in Hepatology & Gastroenterology. 48(6):102364, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Okasha HH; Hegazy MA; Shaker O; Elfatah YA; El-Sawy SS; Abdelfatah D; Abdellatef A
+Authors Full Name
+ Okasha, Hussein Hassan; Hegazy, Mona A; Shaker, Olfat; Elfatah, Yasmine Abd; El-Sawy, Shereen Sadik; Abdelfatah, Dalia; Abdellatef, Abeer.
+Institution
+ Okasha, Hussein Hassan. Internal Medicine Department, Division of Gastroenterology and Hepatology, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
+ Hegazy, Mona A. Internal Medicine Department, Division of Gastroenterology and Hepatology, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
+ Shaker, Olfat. Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Cairo University, Cairo, Egypt.
+ Elfatah, Yasmine Abd. Internal Medicine Department, DM and endocrinology Division, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
+ El-Sawy, Shereen Sadik. Internal Medicine Department, DM and endocrinology Division, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
+ Abdelfatah, Dalia. Cancer epidemiology and Biostatistics department, National Cancer Institute, Cairo University, Cairo, Egypt.
+ Abdellatef, Abeer. Internal Medicine Department, Division of Gastroenterology and Hepatology, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt. Electronic address: Abeerawad@kasralainy.edu.eg.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ Adult
+ Cross-Sectional Studies
+ Egypt/ep [Epidemiology]
+ Fatty Acid-Binding Proteins/bl [Blood]
+ *Fatty Acid-Binding Proteins
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Prospective Studies
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Pancreatic Diseases/bl [Blood]
+ Prevalence
+ Ultrasonography
+Keyword Heading
+ Fatty acid binding protein-1 (FABP1)
+ Fatty liver
+ Non-alcoholic fatty pancreas (NAFPD)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Non-alcoholic fatty pancreas disease (NAFPD) can be detected using various imaging techniques, but accurately measuring the amount of fat in the pancreas remains difficult. Fatty acid binding protein-1 (FABP-1) is a marker specific to certain tissues and can aid in diagnosing NAFPD. However, this study aimed to investigate the prevalence of NAFPD among obese and non-obese people with and without diabetes mellitus (DM). Additionally, it aimed to evaluate the associated risk factors for NAFPD and the utility of the FABP-1 level as a simple, non-invasive biomarker for diagnosing NAFPD.
+
+ METHODS: This study is a prospective cross-sectional study.
+
+ RESULTS: Ninety-five patients were enrolled in the study, comprising 35 males and 60 females, with a mean age of 44 years and a standard deviation (SD) of 11 years. However, 26.3 % were morbidly obese, 22.1 % were severely obese, 31.6 % were obese, 12.6 % were overweight, and 7.4 % were normal. Additionally, 35.8 % had diabetes mellitus, while 26.3 % of patients had hypertension. Regarding the ultrasonographic findings, 94.7 % of the patients had fatty liver, with the majority (41.1 %) classified as grade II, followed by 38.9 % classified as grade I, and 14.7 % classified as grade III fatty liver. Among these patients, 78.9 % had fatty pancreas, with 38.9 % classified as grade II, 31.6 % classified as grade I, and 8.4 % classified as grade III fatty pancreas. The median FABP-1 level among patients with fatty pancreas was 3.3 ng/ml, which exhibited a significant fair negative correlation with total bilirubin and a fair, positive correlation with alkaline phosphatase and portal vein diameter. A statistically substantial distinction was observed between the levels of AFABP-1 and the presence or grading of the fatty pancreas (p-value = 0.048 and < 0.001, respectively). Using multivariate analysis, FABP-1 was the only significant predictor of a fatty pancreas. The receiver operating characteristic (ROC) curve analysis indicated that at a cut-off point of FABP-1 of <= 3.7, it had a sensitivity of 58 %, specificity of 80 %, positive predictive value (PPV) of 96.6 %, negative predictive value (NPV) of 17 %, and an area under the curve (AUC) of 0.77.
+
+ CONCLUSION: NAFPD is becoming an increasingly significant challenge. FABP-1 can potentially be a straightforward and non-invasive predictor of the fatty pancreas. Copyright © 2024 Elsevier Masson SAS. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Fatty Acid-Binding Proteins). 0 (Biomarkers). 0 (FABP1 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1016%2fj.clinre.2024.102364
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Okasha&issn=2210-7401&title=Clinics+%26+Research+in+Hepatology+%26+Gastroenterology&atitle=Study+of+non-alcoholic+fatty+pancreatic+disease+among+the+Egyptian+population+and+the+value+of+serum+fatty+acid+binding+protein-1+%28FABP-1%29+as+a+non-invasive+biomarker.&volume=48&issue=6&spage=102364&epage=&date=2024&doi=10.1016%2Fj.clinre.2024.102364&pmid=38788255&sid=OVID:medline
+
+<12>
+Unique Identifier
+ 36624323
+Title
+ Current Family Functioning and Youth Cardiometabolic Health in the SOL Youth Study.
+Source
+ International Journal of Behavioral Medicine. 30(6):914-923, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Suglia SF; Crookes DM; Belak L; Cammack AL; Clark TL; Daviglus M; Gallo LC; Perreira KM; Delamater AM; Isasi CR
+Author NameID
+ Suglia, Shakira F; ORCID: http://orcid.org/0000-0002-5634-9290
+Authors Full Name
+ Suglia, Shakira F; Crookes, Danielle M; Belak, Lauren; Cammack, Alison L; Clark, Taylor L; Daviglus, Martha; Gallo, Linda C; Perreira, Krista M; Delamater, Alan M; Isasi, Carmen R.
+Institution
+ Suglia, Shakira F. Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA, 30322, USA. Shakira.Suglia@emory.edu.
+ Crookes, Danielle M. Department of Health Sciences, Bouve College of Health Sciences, Department of Sociology & Anthropology, College of Social Sciences & Humanities, Northeastern University, Boston, MA, USA.
+ Belak, Lauren. Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA, 30322, USA.
+ Cammack, Alison L. Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA, 30322, USA.
+ Clark, Taylor L. SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
+ Daviglus, Martha. University of Illinois, Chicago, IL, USA.
+ Gallo, Linda C. Department of Psychology, San Diego State University, San Diego, CA, USA.
+ Perreira, Krista M. Department of Social Medicine, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
+ Delamater, Alan M. Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL, USA.
+ Isasi, Carmen R. Department of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
+MeSH Subject Headings
+ Adolescent
+ Female
+ Humans
+ Male
+ Biomarkers
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Cohort Studies
+ Hispanic or Latino
+ Obesity/ep [Epidemiology]
+ *Obesity
+ *Cardiometabolic Risk Factors
+Keyword Heading
+ BMI
+ Family environment
+ Hispanic/Latino
+ Sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Family functioning may impact children's cardiometabolic health; however, few studies have examined multiple cardiometabolic markers among a diverse racial/ethnic cohort. The relationship between child- and caregiver-reported family functioning and the cardiometabolic health of Hispanic/Latino youth was examined.
+
+ METHOD: Data were from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth) (2012-2014), a population-based cohort study of children and adolescents whose parents participated in the HCHS/SOL (2008-2011). The relationship between youth- and caregiver-rated family functioning, and concordance of ratings is modeled, utilizing the general functioning subscale of the McMaster Family Assessment Device with youth objective cardiometabolic health markers (obesity, central adiposity, prediabetes/diabetes, prehypertension/hypertension, triglycerides, HDL cholesterol) adjusting for sociodemographic factors.
+
+ RESULTS: Among boys, child/caregiver concordant ineffective family functioning rating was associated with higher cumulative cardiometabolic risk (adjusted B (95% CI): 0.30 (0.04, 0.56)), but no association was observed among girls (adjusted B (95% CI): 0.04 (-0.13, 0.21)). Among girls, ineffective child rating/effective caregiver rating was associated with higher cumulative cardiometabolic risk (adjusted B (95% CI): 0.27 (0.06, 0.48)), but no association was observed among boys (adjusted B (95% CI): 0.02 (-0.23, 0.27).
+
+ CONCLUSION: Findings suggest that family functioning among this Hispanic/Latino population may influence cardiometabolic risk among youth. Observed differences in the associations by youth sex and concordant/discordant reports of family functioning suggest interventions at the family level, targeting both caregivers and youth, that consider differential sex effects are warranted. Copyright © 2023. International Society of Behavioral Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1007%2fs12529-022-10148-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Suglia&issn=1070-5503&title=International+Journal+of+Behavioral+Medicine&atitle=Current+Family+Functioning+and+Youth+Cardiometabolic+Health+in+the+SOL+Youth+Study.&volume=30&issue=6&spage=914&epage=923&date=2023&doi=10.1007%2Fs12529-022-10148-9&pmid=36624323&sid=OVID:medline
+
+<13>
+Unique Identifier
+ 38844974
+Title
+ Changes in the combination of the triglyceride-glucose index and obesity indicators estimate the risk of cardiovascular disease.
+Source
+ Cardiovascular Diabetology. 23(1):192, 2024 Jun 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhu X; Xu W; Song T; Wang X; Wang Q; Li J; Liu X; Hao B; Chen T; Guo J
+Authors Full Name
+ Zhu, Xiaoqing; Xu, Weihao; Song, Tingting; Wang, Xinyan; Wang, Qingsong; Li, Jun; Liu, Xixi; Hao, Benchuan; Chen, Tao; Guo, Jun.
+Institution
+ Zhu, Xiaoqing. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Zhu, Xiaoqing. Medical School of Chinese PLA, Beijing, China.
+ Xu, Weihao. Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
+ Xu, Weihao. Department of Geriatrics, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
+ Xu, Weihao. Haikou Cadre's Sanitarium of Hainan Military Region, Haikou, China.
+ Song, Tingting. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Wang, Xinyan. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Wang, Xinyan. Medical School of Chinese PLA, Beijing, China.
+ Wang, Qingsong. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Wang, Qingsong. Medical School of Chinese PLA, Beijing, China.
+ Li, Jun. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Li, Jun. Medical School of Chinese PLA, Beijing, China.
+ Liu, Xixi. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Liu, Xixi. Medical School of Chinese PLA, Beijing, China.
+ Hao, Benchuan. Department of Cardiology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China. haobch301@163.com.
+ Chen, Tao. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China. chentao301@126.com.
+ Guo, Jun. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+MeSH Subject Headings
+ Humans
+ Female
+ Middle Aged
+ Male
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases
+ Prospective Studies
+ Triglycerides/bl [Blood]
+ *Triglycerides
+ Incidence
+ Risk Assessment
+ China/ep [Epidemiology]
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose
+ Obesity/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ Obesity/bl [Blood]
+ *Obesity
+ Aged
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Longitudinal Studies
+ Time Factors
+ Prognosis
+ Heart Disease Risk Factors
+ Predictive Value of Tests
+ Risk Factors
+Keyword Heading
+ Cardiovascular disease
+ K-means clustering
+ Long-term change
+ Obesity indicators
+ Triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Cardiovascular disease (CVD) is closely associated with the triglyceride glucose (TyG) index and its related indicators, particularly its combination with obesity indices. However, there is limited research on the relationship between changes in TyG-related indices and CVD, as most studies have focused on baseline TyG-related indices.
+
+ METHODS: The data for this prospective cohort study were obtained from the China Health and Retirement Longitudinal Study. The exposures were changes in TyG-related indices and cumulative TyG-related indices from 2012 to 2015. The K-means algorithm was used to classify changes in each TyG-related index into four classes (Class 1 to Class 4). Multivariate logistic regressions were used to evaluate the associations between the changes in TyG-related indices and the incidence of CVD.
+
+ RESULTS: In total, 3243 participants were included in this study, of whom 1761 (54.4%) were female, with a mean age of 57.62 years at baseline. Over a 5-year follow-up, 637 (19.6%) participants developed CVD. Fully adjusted logistic regression analyses revealed significant positive associations between changes in TyG-related indices, cumulative TyG-related indices and the incidence of CVD. Among these changes in TyG-related indices, changes in TyG-waist circumference (WC) showed the strongest association with incident CVD. Compared to the participants in Class 1 of changes in TyG-WC, the odds ratio (OR) for participants in Class 2 was 1.41 (95% confidence interval (CI) 1.08-1.84), the OR for participants in Class 3 was 1.54 (95% CI 1.15-2.07), and the OR for participants in Class 4 was 1.94 (95% CI 1.34-2.80). Moreover, cumulative TyG-WC exhibited the strongest association with incident CVD among cumulative TyG-related indices. Compared to the participants in Quartile 1 of cumulative TyG-WC, the OR for participants in Quartile 2 was 1.33 (95% CI 1.00-1.76), the OR for participants in Quartile 3 was 1.46 (95% CI 1.09-1.96), and the OR for participants in Quartile 4 was 1.79 (95% CI 1.30-2.47).
+
+ CONCLUSIONS: Changes in TyG-related indices are independently associated with the risk of CVD. Changes in TyG-WC are expected to become more effective indicators for identifying individuals at a heightened risk of CVD. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1186%2fs12933-024-02281-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhu&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Changes+in+the+combination+of+the+triglyceride-glucose+index+and+obesity+indicators+estimate+the+risk+of+cardiovascular+disease.&volume=23&issue=1&spage=192&epage=&date=2024&doi=10.1186%2Fs12933-024-02281-4&pmid=38844974&sid=OVID:medline
+
+<14>
+Unique Identifier
+ 37980222
+Title
+ Obesity and Impaired Lung Function in Young Adults: The Value of MRI-Derived Biomarkers of Muscle Health.
+Source
+ Academic Radiology. 31(1):19-21, 2024 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Almansour H
+Authors Full Name
+ Almansour, Haidara.
+Institution
+ Almansour, Haidara. Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tuebingen University Hospital, Hoppe-Seyler-str 3, Tuebingen 72076, Germany. Electronic address: haidar.almansour@gmail.com.
+MeSH Subject Headings
+ Humans
+ Young Adult
+ *Obesity
+ *Muscles
+ Biomarkers
+ Lung
+ Magnetic Resonance Imaging
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&DO=10.1016%2fj.acra.2023.10.056
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Almansour&issn=1076-6332&title=Academic+Radiology&atitle=Obesity+and+Impaired+Lung+Function+in+Young+Adults%3A+The+Value+of+MRI-Derived+Biomarkers+of+Muscle+Health.&volume=31&issue=1&spage=19&epage=21&date=2024&doi=10.1016%2Fj.acra.2023.10.056&pmid=37980222&sid=OVID:medline
+
+<15>
+Unique Identifier
+ 38844974
+Title
+ Changes in the combination of the triglyceride-glucose index and obesity indicators estimate the risk of cardiovascular disease.
+Source
+ Cardiovascular Diabetology. 23(1):192, 2024 Jun 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhu X; Xu W; Song T; Wang X; Wang Q; Li J; Liu X; Hao B; Chen T; Guo J
+Authors Full Name
+ Zhu, Xiaoqing; Xu, Weihao; Song, Tingting; Wang, Xinyan; Wang, Qingsong; Li, Jun; Liu, Xixi; Hao, Benchuan; Chen, Tao; Guo, Jun.
+Institution
+ Zhu, Xiaoqing. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Zhu, Xiaoqing. Medical School of Chinese PLA, Beijing, China.
+ Xu, Weihao. Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
+ Xu, Weihao. Department of Geriatrics, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
+ Xu, Weihao. Haikou Cadre's Sanitarium of Hainan Military Region, Haikou, China.
+ Song, Tingting. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Wang, Xinyan. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Wang, Xinyan. Medical School of Chinese PLA, Beijing, China.
+ Wang, Qingsong. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Wang, Qingsong. Medical School of Chinese PLA, Beijing, China.
+ Li, Jun. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Li, Jun. Medical School of Chinese PLA, Beijing, China.
+ Liu, Xixi. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+ Liu, Xixi. Medical School of Chinese PLA, Beijing, China.
+ Hao, Benchuan. Department of Cardiology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China. haobch301@163.com.
+ Chen, Tao. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China. chentao301@126.com.
+ Guo, Jun. Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
+MeSH Subject Headings
+ Humans
+ Female
+ Middle Aged
+ Male
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases
+ Prospective Studies
+ Triglycerides/bl [Blood]
+ *Triglycerides
+ Incidence
+ Risk Assessment
+ China/ep [Epidemiology]
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose
+ Obesity/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ Obesity/bl [Blood]
+ *Obesity
+ Aged
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Longitudinal Studies
+ Time Factors
+ Prognosis
+ Heart Disease Risk Factors
+ Predictive Value of Tests
+ Risk Factors
+Keyword Heading
+ Cardiovascular disease
+ K-means clustering
+ Long-term change
+ Obesity indicators
+ Triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Cardiovascular disease (CVD) is closely associated with the triglyceride glucose (TyG) index and its related indicators, particularly its combination with obesity indices. However, there is limited research on the relationship between changes in TyG-related indices and CVD, as most studies have focused on baseline TyG-related indices.
+
+ METHODS: The data for this prospective cohort study were obtained from the China Health and Retirement Longitudinal Study. The exposures were changes in TyG-related indices and cumulative TyG-related indices from 2012 to 2015. The K-means algorithm was used to classify changes in each TyG-related index into four classes (Class 1 to Class 4). Multivariate logistic regressions were used to evaluate the associations between the changes in TyG-related indices and the incidence of CVD.
+
+ RESULTS: In total, 3243 participants were included in this study, of whom 1761 (54.4%) were female, with a mean age of 57.62 years at baseline. Over a 5-year follow-up, 637 (19.6%) participants developed CVD. Fully adjusted logistic regression analyses revealed significant positive associations between changes in TyG-related indices, cumulative TyG-related indices and the incidence of CVD. Among these changes in TyG-related indices, changes in TyG-waist circumference (WC) showed the strongest association with incident CVD. Compared to the participants in Class 1 of changes in TyG-WC, the odds ratio (OR) for participants in Class 2 was 1.41 (95% confidence interval (CI) 1.08-1.84), the OR for participants in Class 3 was 1.54 (95% CI 1.15-2.07), and the OR for participants in Class 4 was 1.94 (95% CI 1.34-2.80). Moreover, cumulative TyG-WC exhibited the strongest association with incident CVD among cumulative TyG-related indices. Compared to the participants in Quartile 1 of cumulative TyG-WC, the OR for participants in Quartile 2 was 1.33 (95% CI 1.00-1.76), the OR for participants in Quartile 3 was 1.46 (95% CI 1.09-1.96), and the OR for participants in Quartile 4 was 1.79 (95% CI 1.30-2.47).
+
+ CONCLUSIONS: Changes in TyG-related indices are independently associated with the risk of CVD. Changes in TyG-WC are expected to become more effective indicators for identifying individuals at a heightened risk of CVD. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12933-024-02281-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhu&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Changes+in+the+combination+of+the+triglyceride-glucose+index+and+obesity+indicators+estimate+the+risk+of+cardiovascular+disease.&volume=23&issue=1&spage=192&epage=&date=2024&doi=10.1186%2Fs12933-024-02281-4&pmid=38844974&sid=OVID:medline
+
+<16>
+Unique Identifier
+ 38841630
+Title
+ Effects of Omega-3 Supplementation on the Delayed Onset Muscle Soreness after Cycling High Intensity Interval Training in Overweight or Obese Males.
+Source
+ Journal of Sports Science & Medicine. 23(2):317-325, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Makaje N; Ruangthai R; Sae-Tan S
+Authors Full Name
+ Makaje, Niromlee; Ruangthai, Ratree; Sae-Tan, Sudathip.
+Institution
+ Makaje, Niromlee. Department of Sports Science and Health, Faculty of Sports Science, Kasetsart University, Bangkok, Thailand.
+ Ruangthai, Ratree. Department of Sports Science and Health, Faculty of Sports Science, Kasetsart University, Bangkok, Thailand.
+ Sae-Tan, Sudathip. Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok, Thailand.
+MeSH Subject Headings
+ Humans
+ Male
+ Myalgia/pc [Prevention & Control]
+ Myalgia/et [Etiology]
+ Myalgia/th [Therapy]
+ *Myalgia
+ *High-Intensity Interval Training
+ Double-Blind Method
+ *Dietary Supplements
+ Creatine Kinase/bl [Blood]
+ *Creatine Kinase
+ Fatty Acids, Omega-3/ad [Administration & Dosage]
+ *Fatty Acids, Omega-3
+ Overweight/th [Therapy]
+ *Overweight
+ Obesity/th [Therapy]
+ *Obesity
+ Young Adult
+ C-Reactive Protein/an [Analysis]
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Bicycling/ph [Physiology]
+ *Bicycling
+ Adult
+ Leukocyte Count
+ Muscle, Skeletal/de [Drug Effects]
+ Biomarkers/bl [Blood]
+ Sedentary Behavior
+Keyword Heading
+ Delayed onset muscle soreness
+ fish oil
+ high intensity interval training
+ muscle damage
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ People with overweight or obesity preferred high-intensity interval training (HIIT) due to the time-efficiency and pleasure. However, HIIT leads to delayed onset muscle soreness (DOMS). The present study aimed to investigate the effects of omega-3 supplementation on DOMS, muscle damage, and acute inflammatory markers induced by cycling HIIT in untrained males with overweight or obesity. A randomized, double-blinded study was used in the present study. Twenty-four males with a sedentary lifestyle were randomly assigned to either receive omega-3 (O3) (4 g fish oil) or placebo (Con). Subjects consumed the capsules for 4 weeks and performed cycling HIIT at the 4th week. After 4 weeks-intervention, the omega-3 index of O3 group increased by 52.51% compared to the baseline. All subjects performed HIIT at 4th week. The plasma creatine kinase (CK) level of Con group increased throughout 48h after HIIT. While the CK level of O3 group increased only immediately and 24h after HIIT and decreased at 48h after HIIT. The white blood cell count (WBC) of Con group increased immediately after the HIIT, while O3 group did not show such increase. There was no change of CRP in both groups. O3 group had a higher reduction of calf pain score compared to Con group. O3 group also showed a recovery of leg strength faster than Con group. Omega-3 supplementation for 4 weeks lower increased CK level, reduced calf pain score, and recovery leg strength, DOMS markers after cycling HIIT. Copyright © Journal of Sports Science and Medicine.
+Registry Number/Name of Substance
+ EC 2-7-3-2 (Creatine Kinase). 0 (Fatty Acids, Omega-3). 9007-41-4 (C-Reactive Protein). 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.52082%2fjssm.2024.317
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Makaje&issn=1303-2968&title=Journal+of+Sports+Science+%26+Medicine&atitle=Effects+of+Omega-3+Supplementation+on+the+Delayed+Onset+Muscle+Soreness+after+Cycling+High+Intensity+Interval+Training+in+Overweight+or+Obese+Males.&volume=23&issue=2&spage=317&epage=325&date=2024&doi=10.52082%2Fjssm.2024.317&pmid=38841630&sid=OVID:medline
+
+<17>
+Unique Identifier
+ 38834647
+Title
+ Association of systemic inflammatory indices with anthropometric measures, metabolic factors, and liver function in non-alcoholic fatty liver disease.
+Source
+ Scientific Reports. 14(1):12829, 2024 06 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Arefhosseini S; Aghajani T; Tutunchi H; Ebrahimi-Mameghani M
+Authors Full Name
+ Arefhosseini, Sara; Aghajani, Taha; Tutunchi, Helda; Ebrahimi-Mameghani, Mehrangiz.
+Institution
+ Arefhosseini, Sara. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Aghajani, Taha. Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
+ Tutunchi, Helda. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Ebrahimi-Mameghani, Mehrangiz. Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. ebrahimimamagani@tbzmed.ac.ir.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Adult
+ Male
+ Female
+ Middle Aged
+ Cross-Sectional Studies
+ Adolescent
+ *Body Mass Index
+ Young Adult
+ Inflammation/bl [Blood]
+ Inflammation/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Anthropometry
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Obesity/bl [Blood]
+ Liver Function Tests
+ Blood Glucose/me [Metabolism]
+ Waist-Hip Ratio
+Keyword Heading
+ Inflammation
+ Liver function
+ Metabolic factors
+ Non-alcoholic fatty liver disease
+ Systemic inflammatory indices
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The present cross-sectional study aimed to explore the relationship between systemic inflammatory indices (SIIs) and anthropometric measures, metabolic, and liver function biomarkers in patients with non-alcoholic fatty liver disease (NAFLD). This study was carried out on 238 NAFLD patients with overweight or obesity, aged 18-55 years. Anthropometric measurements were done and body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were estimated. Metabolic factors including serum glucose, lipid profile, liver function biomarkers, and complete blood cell count were assessed after a 24-h fasting state. SIIs including the ratios of neutrophil to lymphocyte (NLR), monocytes to lymphocyte (MLR), platelet to lymphocyte (PLR), and monocytes to high-density lipoprotein cholesterol (MHR) were calculated. Results indicate that apart from PLR, all of the SIIs significantly changed by increasing steatosis severity (all p < 0.05). Moreover, changes in NLR showed a significant association with anthropometric indices including waist circumference (p = 0.032), BMI (p = 0.047), and WHtR (p = 0.002), as well as levels of fasting blood sugar (p = 0.045), triglycerides, (p = 0.025) and low-density lipoprotein cholesterol (p = 0.006). The findings also indicate the relations between lipid profile and all studied SIIs, notably MHR and MLR. All of the SIIs exhibited associations with some liver function indices as well. MHR was positively correlated with the metabolic risk factors of NAFLD while, oppositely, PLR was considered as a preventive marker of NAFLD. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1038%2fs41598-024-63381-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Arefhosseini&issn=2045-2322&title=Scientific+Reports&atitle=Association+of+systemic+inflammatory+indices+with+anthropometric+measures%2C+metabolic+factors%2C+and+liver+function+in+non-alcoholic+fatty+liver+disease.&volume=14&issue=1&spage=12829&epage=&date=2024&doi=10.1038%2Fs41598-024-63381-5&pmid=38834647&sid=OVID:medline
+
+<18>
+Unique Identifier
+ 38832038
+Title
+ Identification of potential obese-specific biomarkers and pathways associated with abdominal subcutaneous fat deposition in pig using a comprehensive bioinformatics strategy.
+Source
+ PeerJ. 12:e17486, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang Y; Wang X; Li M; Wang S; Wang H; Chen Q; Lu S
+Author NameID
+ Wang, Shuyan; ORCID: https://orcid.org/0000-0003-0380-5798
+Authors Full Name
+ Yang, Yongli; Wang, Xiaoyi; Li, Mingli; Wang, Shuyan; Wang, Huiyu; Chen, Qiang; Lu, Shaoxiong.
+Institution
+ Yang, Yongli. Faculty of Animal Science and Technology, Yunnan Agricuture University, Kunming, China.
+ Wang, Xiaoyi. Faculty of Animal Science and Technology, Yunnan Agricuture University, Kunming, China.
+ Li, Mingli. Faculty of Animal Science and Technology, Yunnan Agricuture University, Kunming, China.
+ Wang, Shuyan. Faculty of Animal Science and Technology, Yunnan Agricuture University, Kunming, China.
+ Wang, Huiyu. Faculty of Animal Science and Technology, Yunnan Agricuture University, Kunming, China.
+ Wang, Huiyu. Faculty of Animal Science, Xichang University, Xichang, China.
+ Chen, Qiang. Faculty of Animal Science and Technology, Yunnan Agricuture University, Kunming, China.
+ Lu, Shaoxiong. Faculty of Animal Science and Technology, Yunnan Agricuture University, Kunming, China.
+MeSH Subject Headings
+ Animals
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ *Obesity
+ Computational Biology/mt [Methods]
+ *Computational Biology
+ Swine
+ Biomarkers/me [Metabolism]
+ *Biomarkers
+ Subcutaneous Fat, Abdominal/me [Metabolism]
+ *Subcutaneous Fat, Abdominal
+ Protein Interaction Maps
+ Gene Expression Profiling
+ Signal Transduction/ge [Genetics]
+ Gene Regulatory Networks
+Keyword Heading
+ Abdominal subcutaneous fat deposition
+ Biomarkers
+ Hub gene
+ Key pathway
+ Pig
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Abdominal subcutaneous fat deposition (ASFD) is not only related to meat quality in the pig industry but also to human health in medicine. It is of great value to elucidate the potential molecular mechanisms of ASFD. The present study aims to identify obese-specific biomarkers and key pathways correlated with ASFD in pigs. The ASF-related mRNA expression dataset GSE136754 was retrieved from the Gene Expression Omnibus (GEO) database and systematically analyzed using a comprehensive bioinformatics method. A total of 565 differentially expressed genes (DEGs) were identified between three obese and three lean pigs, and these DEGs were mainly involved in the p53 signaling pathway, MAPK signaling pathway and fatty acid metabolism. A protein-protein interaction (PPI) network, consisting of 540 nodes and 1,065 edges, was constructed, and the top ten genes with the highest degree scores-ABL1, HDAC1, CDC42, HDAC2, MRPS5, MRPS10, MDM2, JUP, RPL7L1 and UQCRFS1-were identified as hub genes in the whole PPI network. Especially HDAC1, MDM2, MRPS10 and RPL7L1 were identified as potential robust obese-specific biomarkers due to their significant differences in single gene expression levels and high ROC area; this was further verified by quantitative real-time PCR (qRT-PCR) on abdominal subcutaneous fat samples from obese-type (Saba) and lean-type (Large White) pigs. Additionally, a mRNA-miRNA-lncRNA ceRNA network consisting of four potential biomarkers, 15 miRNAs and 51 lncRNAs was established, and two targeted lncRNAs with more connections, XIST and NEAT1, were identified as potentially important regulatory factors. The findings of this study may provide novel insights into the molecular mechanism involved in ASFD. Copyright © 2024 Yang et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.7717%2fpeerj.17486
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=2167-8359&title=PeerJ&atitle=Identification+of+potential+obese-specific+biomarkers+and+pathways+associated+with+abdominal+subcutaneous+fat+deposition+in+pig+using+a+comprehensive+bioinformatics+strategy.&volume=12&issue=&spage=e17486&epage=&date=2024&doi=10.7717%2Fpeerj.17486&pmid=38832038&sid=OVID:medline
+
+<19>
+Unique Identifier
+ 38590187
+Title
+ Adipose-derived miRNAs as potential biomarkers for predicting adulthood obesity and its complications: A systematic review and bioinformatic analysis. [Review]
+Source
+ Obesity Reviews. 25(7):e13748, 2024 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu X; Sun H; Zheng L; Zhang J; Su H; Li B; Wu Q; Liu Y; Xu Y; Song X; Yu Y
+Author NameID
+ Yu, Yang; ORCID: https://orcid.org/0000-0002-2480-7306
+Authors Full Name
+ Liu, Xiyan; Sun, Huayi; Zheng, Lixia; Zhang, Jian; Su, Han; Li, Bingjie; Wu, Qianhui; Liu, Yunchan; Xu, Yingxi; Song, Xiaoyu; Yu, Yang.
+Institution
+ Liu, Xiyan. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Liu, Xiyan. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Sun, Huayi. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Sun, Huayi. Department of Colorectal Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
+ Zheng, Lixia. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Zheng, Lixia. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Zhang, Jian. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Zhang, Jian. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+ Su, Han. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Su, Han. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Li, Bingjie. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Li, Bingjie. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+ Wu, Qianhui. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Wu, Qianhui. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+ Liu, Yunchan. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Liu, Yunchan. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+ Xu, Yingxi. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Xu, Yingxi. Department of Clinical Nutrition, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
+ Song, Xiaoyu. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Song, Xiaoyu. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Yu, Yang. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning, China.
+ Yu, Yang. Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
+ Yu, Yang. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, Liaoning, China.
+MeSH Subject Headings
+ Humans
+ Obesity/ge [Genetics]
+ Obesity/co [Complications]
+ *Obesity
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ *Computational Biology
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ *Biomarkers
+Keyword Heading
+ adipose tissue
+ circulating miRNAs
+ comorbidity
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipose tissue is the first and primary target organ of obesity and the main source of circulating miRNAs in patients with obesity. This systematic review aimed to analyze and summarize the generation and mechanisms of adipose-derived miRNAs and their role as early predictors of various obesity-related complications. Literature searches in the PubMed and Web of Science databases using terms related to miRNAs, obesity, and adipose tissue. Pre-miRNAs from the Human MicroRNA Disease Database, known to regulate obesity-related metabolic disorders, were combined for intersection processing. Validated miRNA targets were sorted through literature review, and enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes via the KOBAS online tool, disease analysis, and miRNA transcription factor prediction using the TransmiR v. 2.0 database were also performed. Thirty miRNAs were identified using both obesity and adipose secretion as criteria. Seventy-nine functionally validated targets associated with 30 comorbidities of these miRNAs were identified, implicating pathways such as autophagy, p53 pathways, and inflammation. The miRNA precursors were analyzed to predict their transcription factors and explore their biosynthesis mechanisms. Our findings offer potential insights into the epigenetic changes related to adipose-driven obesity-related comorbidities. Copyright © 2024 World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (MicroRNAs). 0 (Biomarkers).
+Publication Type
+ Systematic Review. Journal Article. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fobr.13748
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=1467-7881&title=Obesity+Reviews&atitle=Adipose-derived+miRNAs+as+potential+biomarkers+for+predicting+adulthood+obesity+and+its+complications%3A+A+systematic+review+and+bioinformatic+analysis.&volume=25&issue=7&spage=e13748&epage=&date=2024&doi=10.1111%2Fobr.13748&pmid=38590187&sid=OVID:medline
+
+<20>
+Unique Identifier
+ 36624323
+Title
+ Current Family Functioning and Youth Cardiometabolic Health in the SOL Youth Study.
+Source
+ International Journal of Behavioral Medicine. 30(6):914-923, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Suglia SF; Crookes DM; Belak L; Cammack AL; Clark TL; Daviglus M; Gallo LC; Perreira KM; Delamater AM; Isasi CR
+Author NameID
+ Suglia, Shakira F; ORCID: http://orcid.org/0000-0002-5634-9290
+Authors Full Name
+ Suglia, Shakira F; Crookes, Danielle M; Belak, Lauren; Cammack, Alison L; Clark, Taylor L; Daviglus, Martha; Gallo, Linda C; Perreira, Krista M; Delamater, Alan M; Isasi, Carmen R.
+Institution
+ Suglia, Shakira F. Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA, 30322, USA. Shakira.Suglia@emory.edu.
+ Crookes, Danielle M. Department of Health Sciences, Bouve College of Health Sciences, Department of Sociology & Anthropology, College of Social Sciences & Humanities, Northeastern University, Boston, MA, USA.
+ Belak, Lauren. Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA, 30322, USA.
+ Cammack, Alison L. Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA, 30322, USA.
+ Clark, Taylor L. SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
+ Daviglus, Martha. University of Illinois, Chicago, IL, USA.
+ Gallo, Linda C. Department of Psychology, San Diego State University, San Diego, CA, USA.
+ Perreira, Krista M. Department of Social Medicine, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
+ Delamater, Alan M. Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL, USA.
+ Isasi, Carmen R. Department of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
+MeSH Subject Headings
+ Adolescent
+ Female
+ Humans
+ Male
+ Biomarkers
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Cohort Studies
+ Hispanic or Latino
+ Obesity/ep [Epidemiology]
+ *Obesity
+ *Cardiometabolic Risk Factors
+Keyword Heading
+ BMI
+ Family environment
+ Hispanic/Latino
+ Sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Family functioning may impact children's cardiometabolic health; however, few studies have examined multiple cardiometabolic markers among a diverse racial/ethnic cohort. The relationship between child- and caregiver-reported family functioning and the cardiometabolic health of Hispanic/Latino youth was examined.
+
+ METHOD: Data were from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth) (2012-2014), a population-based cohort study of children and adolescents whose parents participated in the HCHS/SOL (2008-2011). The relationship between youth- and caregiver-rated family functioning, and concordance of ratings is modeled, utilizing the general functioning subscale of the McMaster Family Assessment Device with youth objective cardiometabolic health markers (obesity, central adiposity, prediabetes/diabetes, prehypertension/hypertension, triglycerides, HDL cholesterol) adjusting for sociodemographic factors.
+
+ RESULTS: Among boys, child/caregiver concordant ineffective family functioning rating was associated with higher cumulative cardiometabolic risk (adjusted B (95% CI): 0.30 (0.04, 0.56)), but no association was observed among girls (adjusted B (95% CI): 0.04 (-0.13, 0.21)). Among girls, ineffective child rating/effective caregiver rating was associated with higher cumulative cardiometabolic risk (adjusted B (95% CI): 0.27 (0.06, 0.48)), but no association was observed among boys (adjusted B (95% CI): 0.02 (-0.23, 0.27).
+
+ CONCLUSION: Findings suggest that family functioning among this Hispanic/Latino population may influence cardiometabolic risk among youth. Observed differences in the associations by youth sex and concordant/discordant reports of family functioning suggest interventions at the family level, targeting both caregivers and youth, that consider differential sex effects are warranted. Copyright © 2023. International Society of Behavioral Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs12529-022-10148-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Suglia&issn=1070-5503&title=International+Journal+of+Behavioral+Medicine&atitle=Current+Family+Functioning+and+Youth+Cardiometabolic+Health+in+the+SOL+Youth+Study.&volume=30&issue=6&spage=914&epage=923&date=2023&doi=10.1007%2Fs12529-022-10148-9&pmid=36624323&sid=OVID:medline
+
+<21>
+Unique Identifier
+ 38813505
+Title
+ Evaluation of sestrin 2 and tribbles homolog 3 levels in obese and nonobese women with polycystic ovary syndrome.
+Source
+ Turkish Journal of Medical Sciences. 53(6):1697-1703, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Catal A; Kovalak EE
+Author NameID
+ Catal, Aysegul; ORCID: https://orcid.org/0000-0002-0411-3999
+ Kovalak, Evrim Ebru; ORCID: https://orcid.org/0000-0001-5311-1060
+Authors Full Name
+ Catal, Aysegul; Kovalak, Evrim Ebru.
+Institution
+ Catal, Aysegul. Department of Medical Biochemistry, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkiye.
+ Kovalak, Evrim Ebru. Department of Obstetrics and Gynecology, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkiye.
+MeSH Subject Headings
+ Humans
+ Female
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/co [Complications]
+ *Polycystic Ovary Syndrome
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity
+ Adult
+ Case-Control Studies
+ Cross-Sectional Studies
+ Protein Serine-Threonine Kinases/bl [Blood]
+ Protein Serine-Threonine Kinases/ai [Antagonists & Inhibitors]
+ *Protein Serine-Threonine Kinases
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Insulin Resistance/ph [Physiology]
+ Nuclear Proteins/bl [Blood]
+ Young Adult
+ Blood Glucose/me [Metabolism]
+ Blood Glucose/an [Analysis]
+ Sestrins
+ Repressor Proteins
+ Cell Cycle Proteins
+Keyword Heading
+ Insulin resistance
+ obesity
+ polycystic ovary syndrome
+ sestrin 2
+ tribbles homolog 3
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background/aim: This study was designed to evaluate the relationship of two new biomarkers [tribbles homolog 3 (TRB3) and sestrin 2 levels], which were previously associated with obesity, with metabolic parameters in obese and nonobese women with polycystic ovary syndrome (PCOS).
+
+ Materials and methods: This cross-sectional case control study was conducted between September 2017 and August 2019 in the gynecology department of a tertiary referral hospital. The values of the plasma sestrin 2, TRB3, insulin, fasting plasma glucose, lipid profile, and homeostasis model assessment of insulin resistance (HOMA-IR) were compared in 90 obese women with PCOS (BMI > 30), 90 women with nonobese PCOS (BMI < 30), and 90 control patients (BMI < 30).
+
+ Results: The mean age of the study group consisting of all PCOS patients (26.11 +/- 4.64 years) and the mean age of the control group (26.3 +/- 4.4 years) were statistically similar (p = 0.239). The serum sestrin 2 values of the obese PCOS group were found to be statistically significantly lower than the control and non-obese PCOS groups (p = 0.001, p = 0.0001), while the sestrin 2 values of the nonobese PCOS group were found to be statistically significantly lower than the control group (p = 0.0001). The TRB3 values of the control group were found to be statistically significantly lower than the obese and nonobese PCOS groups (p = 0.0001), while the TRB3 values of the nonobese PCOS group were found to be statistically significantly lower than the obese PCOS group (p = 0.0001). A negative correlation was observed between the sestrin 2 level and BMI (r = -0.272 p = 0.0001), insulin (r = -0.261 p = 0.0001), and HOMA-IR levels (r = -0.250 p = 0.0001). A positive correlation was observed between the TRB3 values and TG (r = 0.248 p = 0.0001), and LDL-C values (r = 0.235 p = 0.0001).
+
+ Conclusion: According to the findings in this study, low sestrin 2 and high TRB3 levels may be related to impaired metabolic status in the obese PCOS group. Thus, it may be promising for the development of treatment of PCOS and associated metabolic disorder in the future. Copyright © TUBITAK.
+Registry Number/Name of Substance
+ 0 (TRIB3 protein, human). 0 (SESN2 protein, human). EC 2-7-11-1 (Protein Serine-Threonine Kinases). 0 (Biomarkers). 0 (Nuclear Proteins). 0 (Blood Glucose). 0 (Sestrins). 0 (Repressor Proteins). 0 (Cell Cycle Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.55730%2f1300-0144.5738
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Catal&issn=1300-0144&title=Turkish+Journal+of+Medical+Sciences&atitle=Evaluation+of+sestrin+2+and+tribbles+homolog+3+levels+in+obese+and+nonobese+women+with+polycystic+ovary+syndrome.&volume=53&issue=6&spage=1697&epage=1703&date=2023&doi=10.55730%2F1300-0144.5738&pmid=38813505&sid=OVID:medline
+
+<22>
+Unique Identifier
+ 38469624
+Title
+ Association Between Pro-inflammatory Cytokine Levels (IL-1beta, IL-6, and TNF-alpha) in Human Colostrum and Maternal Body Composition Components.
+Source
+ Breastfeeding Medicine: The Official Journal of the Academy of Breastfeeding Medicine. 19(5):349-356, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Murguia-Vazquez M; Salgado-Bustamante M; Lima-Rogel V; Flores-Garcia JA; Pierdant-Perez M
+Author NameID
+ Pierdant-Perez, Mauricio; ORCID: https://orcid.org/0000-0002-4606-0071
+Authors Full Name
+ Murguia-Vazquez, Maria; Salgado-Bustamante, Mariana; Lima-Rogel, Victoria; Flores-Garcia, Jose Andres; Pierdant-Perez, Mauricio.
+Institution
+ Murguia-Vazquez, Maria. Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico.
+ Salgado-Bustamante, Mariana. Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico.
+ Lima-Rogel, Victoria. Hospital Central "Dr. Ignacio Morones Prieto", San Luis Potosi, Mexico.
+ Flores-Garcia, Jose Andres. Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico.
+ Pierdant-Perez, Mauricio. Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico.
+MeSH Subject Headings
+ Humans
+ Female
+ Colostrum/ch [Chemistry]
+ *Colostrum
+ Adult
+ Cross-Sectional Studies
+ Tumor Necrosis Factor-alpha/an [Analysis]
+ Tumor Necrosis Factor-alpha/me [Metabolism]
+ *Tumor Necrosis Factor-alpha
+ Interleukin-6/me [Metabolism]
+ Interleukin-6/an [Analysis]
+ *Interleukin-6
+ Interleukin-1beta/an [Analysis]
+ Interleukin-1beta/me [Metabolism]
+ *Interleukin-1beta
+ *Body Composition
+ *Postpartum Period
+ Obesity/me [Metabolism]
+ *Obesity
+ Overweight/me [Metabolism]
+ Pregnancy
+ Milk, Human/ch [Chemistry]
+ Biomarkers/an [Analysis]
+ Young Adult
+Keyword Heading
+ body composition
+ breastfeeding
+ colostrum
+ cytokines
+ electric impedance
+ interleukin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Obesity is characterized as a low-grade chronic inflammatory state, marked by elevated inflammatory biomarkers. Breast milk (BM) is rich in nutritional elements, vitamins, minerals, immunological factors, and bioactive components. These bioactive components, capable of influencing biological processes, may vary in concentration based on maternal body composition. Research Aim/Question(s): This study aimed to explore the association between pro-inflammatory cytokine levels (interleukin-1 beta [IL-1beta], interleukin-6 [IL-6], and tumor necrosis factor-alpha [TNF-alpha]) in human colostrum and maternal body composition, as analyzed through bioelectrical impedance vector analysis (BIVA). Method: In this cross-sectional study, 117 healthy postpartum participants were included, with each group (normal weight, overweight, and obese) comprising 39 individuals, as classified by BIVA. Colostrum samples were collected within the first 24 hours postpartum. Results: IL-1beta levels did not significantly differ across the groups, with concentrations of 69.5 +/- 103 pg/mL in normal-weight, 79.7 +/- 97.9 pg/mL in overweight, and 68.7 +/- 108 pg/mL in obese women. IL-6 levels were significantly higher in the overweight group (55 +/- 72.4 pg/mL) than in the normal-weight (48.1 +/- 74.1 pg/mL) and obese groups (28.9 +/- 36.2 pg/mL) (p = 0.02). Similarly, TNF-alpha levels were higher in the overweight group, with concentrations of 58.7 +/- 74.9 pg/mL, than in the normal-weight group, with concentrations of 38.6 +/- 95.4 pg/mL, and 52.6 +/- 115 pg/mL in obese women (p = 0.02). Conclusion: This study shows that IL-6 and TNF-alpha concentrations were statistically higher in the colostrum of overweight women, suggesting that maternal body composition may influence the inflammatory profile of BM.
+Registry Number/Name of Substance
+ 0 (Tumor Necrosis Factor-alpha). 0 (Interleukin-6). 0 (Interleukin-1beta). 0 (Biomarkers). 0 (IL1B protein, human). 0 (IL6 protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1089%2fbfm.2023.0263
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Murguia-Vazquez&issn=1556-8253&title=Breastfeeding+Medicine%3A+The+Official+Journal+of+the+Academy+of+Breastfeeding+Medicine&atitle=Association+Between+Pro-inflammatory+Cytokine+Levels+%28IL-1beta%2C+IL-6%2C+and+TNF-alpha%29+in+Human+Colostrum+and+Maternal+Body+Composition+Components.&volume=19&issue=5&spage=349&epage=356&date=2024&doi=10.1089%2Fbfm.2023.0263&pmid=38469624&sid=OVID:medline
+
+<23>
+Unique Identifier
+ 37950099
+Title
+ The role of irisin in predicting obstructive sleep apnea severity among obese individuals: a comparative analysis.
+Source
+ Sleep & Breathing. 28(2):951-958, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yildiz H; Alp HH
+Author NameID
+ Yildiz, Hanifi; ORCID: http://orcid.org/0000-0003-0735-5034
+ Alp, Hamit Hakan; ORCID: https://orcid.org/0000-0002-9202-4944
+Authors Full Name
+ Yildiz, Hanifi; Alp, Hamit Hakan.
+Institution
+ Yildiz, Hanifi. Faculty of Medicine, Department of Chest Medicine, Van Yuzuncu Yil University, 65080, Van, Turkey. yhanifi1980@gmail.com.
+ Alp, Hamit Hakan. Faculty of Medicine, Department of Biochemistry, Van Yuzuncu Yil University, Van, Turkey.
+MeSH Subject Headings
+ Humans
+ Sleep Apnea, Obstructive/bl [Blood]
+ Sleep Apnea, Obstructive/di [Diagnosis]
+ *Sleep Apnea, Obstructive
+ Male
+ Fibronectins/bl [Blood]
+ *Fibronectins
+ Female
+ Adult
+ Middle Aged
+ *Polysomnography
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity
+ Biomarkers/bl [Blood]
+ Body Mass Index
+Keyword Heading
+ AHI
+ Irisin
+ Obstructive sleep apnea
+ Predictive value
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: This study aimed to investigate the predictive value of circulating irisin levels in discriminating the presence and severity of obstructive sleep apnea (OSA) in obese individuals.
+
+ METHODS: This study was conducted on obese volunteers with and without OSA. All volunteers underwent polysomnography. Blood samples were taken on the day of the test. In addition to routine biochemistry studies, irisin levels were determined by enzyme-linked immunosorbent measurement. ROC analysis was performed to determine the predictive value of irisin.
+
+ RESULTS: Of 100 volunteers, 75 had OSA and 25 did not. Irisin levels were significantly lower in the group with OSA than in the non-OSA group. The lowest irisin levels were determined in the group with severe OSA. Irisin levels showed high sensitivity and specificity in distinguishing between OSA and non-OSA groups. It had high sensitivity and specificity in differentiating severe OSA from other groups in subgroups, while it had low sensitivity and specificity in differentiating patients with mild and moderate OSA. In logistic regression analysis, a low irisin level was determined to be a risk factor for OSA independent of BMI.
+
+ CONCLUSION: This study indicated that irisin levels decrease in obese individuals with OSA, correlating with the severity of the condition. Additionally, irisin levels may act as an independent predictor for OSA. The predictive value of irisin in identifying severe OSA among obese patients suggests its potential as a promising biomarker. Copyright © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
+Registry Number/Name of Substance
+ 0 (Fibronectins). 0 (FNDC5 protein, human). 0 (Biomarkers).
+Publication Type
+ Journal Article. Comparative Study.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs11325-023-02947-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yildiz&issn=1520-9512&title=Sleep+%26+Breathing&atitle=The+role+of+irisin+in+predicting+obstructive+sleep+apnea+severity+among+obese+individuals%3A+a+comparative+analysis.&volume=28&issue=2&spage=951&epage=958&date=2024&doi=10.1007%2Fs11325-023-02947-5&pmid=37950099&sid=OVID:medline
+
+<24>
+Unique Identifier
+ 38621331
+Title
+ The sex-dependent impact of adipose tissue and inflammation on chronic pain - A cross-sectional study from the all of us research program.
+Source
+ Cytokine. 179:156614, 2024 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Berwal D; Branisteanu DD; Glickman M; Sagar A; Pilitsis JG
+Authors Full Name
+ Berwal, Deepak; Branisteanu, Dumitru D; Glickman, Mia; Sagar, Amit; Pilitsis, Julie G.
+Institution
+ Berwal, Deepak. Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
+ Branisteanu, Dumitru D. Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA; Department of Endocrinology, University of Medicine and Pharmacy "Grigore T. Popa" Iasi, Romania.
+ Glickman, Mia. Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
+ Sagar, Amit. Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
+ Pilitsis, Julie G. Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA; Department of Neurosurgery, University of Arizona College of Medicine, Tucson, AZ, USA. Electronic address: jpilitsis@yahoo.com.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ *Chronic Pain
+ Cross-Sectional Studies
+ *Inflammation
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue
+ Middle Aged
+ Leptin/bl [Blood]
+ Leptin/me [Metabolism]
+ *Leptin
+ Interleukin-6/bl [Blood]
+ Interleukin-6/me [Metabolism]
+ *Interleukin-6
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Waist Circumference
+ Adult
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ United States/ep [Epidemiology]
+ Sex Characteristics
+ Sex Factors
+ Aged
+ Obesity/co [Complications]
+Keyword Heading
+ Adipokines
+ Adipose tissue
+ Chronic pain
+ Hip waist circumference
+ Inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Emerging evidence suggests an association between chronic pain and elevated body fat. We sought to determine if individuals with higher body fat, measured by hip circumference (HC) and waist circumference (WC), are at risk for chronic pain when they demonstrate higher expression of inflammatory markers. We investigated the incidence and severity of pain in patients with varying WC/HC and inflammatory markers (C-Reactive Protein, IL-6, leptin) using the NIH-sponsored All of Us Database. For each inflammatory marker and sex, participants were divided into four groups based on combinations of normal/high marker levels and small/large WC/HC. We used statistical analysis to compare WC/HC and pain severity (mean NRS pain score) between groups of the same sex. In females, but not males, combinations of elevated CRP with large WC/HC exerted additive effects on the incidence of chronic pain (p < 0.01) and severe pain (p < 0.001), as well as on the severity of pain evaluated by the mean NRS pain score (p < 0.01). This relationship held true for females with high IL-6 or leptin and large WC or HC (p < 0.001 for chronic pain and severe pain incidence, and p < 0.05 for pain severity). Neither IL-6 nor leptin showed any significant impact on pain in males. Obesity status and CRP exert additive prognostic effects for chronic pain in females, but not in males. The concomitant evaluation of other inflammatory factors, such as IL-6 or leptin in females, may further augment the prediction of chronic pain. PERSPECTIVE: This article investigates the relationship between chronic pain, obesity, and inflammatory markers. It could help elucidating sex difference in pain mechanisms, as well as the risk factors for chronic pain, potentially improving patient diagnosis, follow-up and treatment. Copyright © 2024 Elsevier Ltd. All rights reserved.
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.cyto.2024.156614
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Berwal&issn=1043-4666&title=Cytokine&atitle=The+sex-dependent+impact+of+adipose+tissue+and+inflammation+on+chronic+pain+-+A+cross-sectional+study+from+the+all+of+us+research+program.&volume=179&issue=&spage=156614&epage=&date=2024&doi=10.1016%2Fj.cyto.2024.156614&pmid=38621331&sid=OVID:medline
+
+<25>
+Unique Identifier
+ 38578969
+Title
+ Characterization of the Small Bowel Microbiome Reveals Different Profiles in Human Subjects Who Are Overweight or Have Obesity.
+Source
+ American Journal of Gastroenterology. 119(6):1141-1153, 2024 Jun 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leite G; Barlow GM; Rashid M; Hosseini A; Cohrs D; Parodi G; Morales W; Weitsman S; Rezaie A; Pimentel M; Mathur R
+Author NameID
+ Leite, Gabriela; ORCID: https://orcid.org/0000-0001-5772-7735
+ Barlow, Gillian M; ORCID: https://orcid.org/0000-0002-0487-048
+ Rashid, Mohamad; ORCID: https://orcid.org/0000-0002-1256-9478
+ Hosseini, Ava; ORCID: https://orcid.org/0000-0002-1979-3034
+ Cohrs, Daniel; ORCID: https://orcid.org/0000-0002-9595-4856
+ Weitsman, Stacy; ORCID: https://orcid.org/0009-0006-7069-701
+ Rezaie, Ali; ORCID: https://orcid.org/0000-0002-0106-372
+ Pimentel, Mark; ORCID: https://orcid.org/0000-0002-0619-5115
+ Mathur, Ruchi; ORCID: https://orcid.org/0000-0003-1053-6557
+Authors Full Name
+ Leite, Gabriela; Barlow, Gillian M; Rashid, Mohamad; Hosseini, Ava; Cohrs, Daniel; Parodi, Gonzalo; Morales, Walter; Weitsman, Stacy; Rezaie, Ali; Pimentel, Mark; Mathur, Ruchi.
+Institution
+ Leite, Gabriela. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Barlow, Gillian M. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Rashid, Mohamad. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Hosseini, Ava. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Cohrs, Daniel. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Parodi, Gonzalo. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Morales, Walter. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Weitsman, Stacy. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Rezaie, Ali. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Rezaie, Ali. Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai, Los Angeles, California, USA.
+ Pimentel, Mark. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Pimentel, Mark. Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai, Los Angeles, California, USA.
+ Mathur, Ruchi. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
+ Mathur, Ruchi. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai, Los Angeles, California, USA .
+MeSH Subject Headings
+ Humans
+ Obesity/mi [Microbiology]
+ *Obesity
+ Female
+ Male
+ Overweight/mi [Microbiology]
+ *Overweight
+ Middle Aged
+ *Gastrointestinal Microbiome
+ Adult
+ Duodenum/mi [Microbiology]
+ RNA, Ribosomal, 16S/ge [Genetics]
+ Biomarkers/bl [Blood]
+ Lactobacillus/ip [Isolation & Purification]
+ Bifidobacterium/ip [Isolation & Purification]
+ Aged
+Abstract
+ INTRODUCTION: Gut microbiome changes are linked to obesity, but findings are based on stool data. In this article, we analyzed the duodenal microbiome and serum biomarkers in subjects with normal weight, overweight, and obesity.
+
+ METHODS: Duodenal aspirates and serum samples were obtained from subjects undergoing standard-of-care esophagogastroduodenoscopy without colon preparation. Aspirate DNAs were analyzed by 16S rRNA and shotgun sequencing. Predicted microbial metabolic functions and serum levels of metabolic and inflammatory biomarkers were also assessed.
+
+ RESULTS: Subjects with normal weight (N = 105), overweight (N = 67), and obesity (N = 42) were identified. Overweight-specific duodenal microbial features include lower relative abundance (RA) of Bifidobacterium species and Escherichia coli strain K-12 and higher Lactobacillus intestinalis , L. johnsonii , and Prevotella loescheii RA. Obesity-specific features include higher Lactobacillus gasseri RA and lower L. reuteri (subspecies rodentium ), Alloprevotella rava , and Leptotrichia spp RA. Escalation features (progressive changes from normal weight through obesity) include decreasing Bacteroides pyogenes , Staphylococcus hominis , and unknown Faecalibacterium species RA, increasing RA of unknown Lactobacillus and Mycobacterium species, and decreasing microbial potential for biogenic amines metabolism. De-escalation features (direction of change altered in normal to overweight and overweight to obesity) include Lactobacillus acidophilus , L. hominis , L. iners , and Bifidobacterium dentium . An unknown Lactobacillus species is associated with type IIa dyslipidemia and overweight, whereas Alloprevotella rava is associated with type IIb and IV dyslipidemias.
+
+ DISCUSSION: Direct analysis of the duodenal microbiome has identified key genera associated with overweight and obesity, including some previously identified in stool, e.g., Bifidobacterium and Lactobacillus . Specific species and strains exhibit differing associations with overweight and obesity, including escalation and de-escalation features that may represent targets for future study and therapeutics. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
+Registry Number/Name of Substance
+ 0 (RNA, Ribosomal, 16S). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.14309%2fajg.0000000000002790
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leite&issn=0002-9270&title=American+Journal+of+Gastroenterology&atitle=Characterization+of+the+Small+Bowel+Microbiome+Reveals+Different+Profiles+in+Human+Subjects+Who+Are+Overweight+or+Have+Obesity.&volume=119&issue=6&spage=1141&epage=1153&date=2024&doi=10.14309%2Fajg.0000000000002790&pmid=38578969&sid=OVID:medline
+
+<26>
+Unique Identifier
+ 37525338
+Title
+ The effects of extracellular vesicles and their cargo on metabolism and its adaptation to physical exercise in insulin resistance and type 2 diabetes. [Review]
+Source
+ Proteomics. 24(11):e2300078, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mastrototaro L; Roden M
+Author NameID
+ Mastrototaro, Lucia; ORCID: https://orcid.org/0000-0003-3604-6636
+Authors Full Name
+ Mastrototaro, Lucia; Roden, Michael.
+Institution
+ Mastrototaro, Lucia. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Dusseldorf, Dusseldorf, Germany.
+ Mastrototaro, Lucia. German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Roden, Michael. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Dusseldorf, Dusseldorf, Germany.
+ Roden, Michael. German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Roden, Michael. Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
+MeSH Subject Headings
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Humans
+ Extracellular Vesicles/me [Metabolism]
+ *Extracellular Vesicles
+ *Insulin Resistance
+ Exercise/ph [Physiology]
+ *Exercise
+ Animals
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/me [Metabolism]
+ Obesity/th [Therapy]
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ diabetes mellitus
+ exercise
+ exerkines
+ extracellular vesicles
+ organ crosstalk
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Lifestyle modification represents the first-line strategy for the prevention and treatment of type 2 diabetes mellitus (T2DM), which is frequently associated with obesity and characterized by defective pancreatic insulin secretion and/or insulin resistance. Exercise training is an essential component of lifestyle modification and has been shown to ameliorate insulin resistance by reducing body fat mass and by enhancing skeletal muscle mitochondrial biogenesis and insulin-independent glucose uptake. Additionally, exercising stimulates the release of exerkines such as metabolites or cytokines, but also long non-coding RNA, microRNAs, cell-free DNA (cf-DNA), and extracellular vesicles (EVs), which contribute to inter-tissue communication. There is emerging evidence that EV number and content are altered in obesity and T2DM and may be involved in several metabolic processes, specifically either worsening or improving insulin resistance. This review summarizes the current knowledge on the metabolic effects of exercise training and on the potential role of humoral factors and EV as new biomarkers for early diagnosis and tailored treatment of T2DM. Copyright © 2023 Wiley-VCH GmbH.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1002%2fpmic.202300078
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mastrototaro&issn=1615-9853&title=Proteomics&atitle=The+effects+of+extracellular+vesicles+and+their+cargo+on+metabolism+and+its+adaptation+to+physical+exercise+in+insulin+resistance+and+type+2+diabetes.&volume=24&issue=11&spage=e2300078&epage=&date=2024&doi=10.1002%2Fpmic.202300078&pmid=37525338&sid=OVID:medline
+
+<27>
+Unique Identifier
+ 36603833
+Title
+ Understanding Health Disparities in Preeclampsia: A Literature Review. [Review]
+Source
+ American Journal of Perinatology. 41(S 01):e1291-e1300, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Conklin MB; Wells BM; Doe EM; Strother AM; Tarasiewicz MEB; Via ER; Conrad LB; Farias-Eisner R
+Authors Full Name
+ Conklin, Mary B; Wells, Brittney M; Doe, Emily M; Strother, Athena M; Tarasiewicz, Megan E Burnett; Via, Emily R; Conrad, Lesley B; Farias-Eisner, Robin.
+Institution
+ Conklin, Mary B. School of Medicine, Creighton University, Omaha, Nebraska.
+ Conklin, Mary B. Department of Obstetrics and Gynecology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
+ Wells, Brittney M. School of Medicine, Creighton University, Omaha, Nebraska.
+ Doe, Emily M. School of Medicine, Creighton University, Omaha, Nebraska.
+ Strother, Athena M. School of Medicine, Creighton University, Omaha, Nebraska.
+ Tarasiewicz, Megan E Burnett. School of Medicine, Creighton University, Omaha, Nebraska.
+ Via, Emily R. School of Medicine, Creighton University, Omaha, Nebraska.
+ Via, Emily R. Department of Obstetrics and Gynecology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
+ Conrad, Lesley B. School of Medicine, Creighton University, Omaha, Nebraska.
+ Conrad, Lesley B. Department of Obstetrics and Gynecology, School of Medicine, Creighton University, Omaha, Nebraska.
+ Conrad, Lesley B. Lynch Comprehensive Cancer Research Center, School of Medicine, Creighton University, Omaha, Nebraska.
+ Farias-Eisner, Robin. School of Medicine, Creighton University, Omaha, Nebraska.
+ Farias-Eisner, Robin. Department of Obstetrics and Gynecology, School of Medicine, Creighton University, Omaha, Nebraska.
+ Farias-Eisner, Robin. Lynch Comprehensive Cancer Research Center, School of Medicine, Creighton University, Omaha, Nebraska.
+ Farias-Eisner, Robin. College of Osteopathic Medicine of the Pacific Northwest, Western University of Health Sciences, Pomona, California.
+ Farias-Eisner, Robin. Department of Obstetrics and Gynecology, David Geffen School of Medicine, the University of California at Los Angeles, Los Angeles, California.
+MeSH Subject Headings
+ Female
+ Humans
+ Pregnancy
+ Apolipoprotein L1/ge [Genetics]
+ Biomarkers/bl [Blood]
+ Black or African American/ge [Genetics]
+ Factor V/ge [Genetics]
+ Genetic Predisposition to Disease
+ *Health Status Disparities
+ Hypertension/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Obesity/ep [Epidemiology]
+ Polymorphism, Genetic
+ Pre-Eclampsia/ge [Genetics]
+ Pre-Eclampsia/ep [Epidemiology]
+ *Pre-Eclampsia
+ Prevalence
+ Risk Factors
+ Social Determinants of Health
+ United States/ep [Epidemiology]
+ White People/ge [Genetics]
+Abstract
+ Preeclampsia is a multifactorial pathology with negative outcomes in affected patients in both the peripartum and postpartum period. Black patients in the United States, when compared to their White and Hispanic counterparts, have higher rates of preeclampsia. This article aims to review the current literature to investigate how race, social determinants of health, and genetic profiles influence the prevalence and outcomes of patients with preeclampsia. Published studies utilized in this review were identified through PubMed using authors' topic knowledge and a focused search through a Medline search strategy. These articles were thoroughly reviewed to explore the contributing biosocial factors, genes/biomarkers, as well as negative outcomes associated with disparate rates of preeclampsia. Increased rates of contributing comorbidities, including hypertension and obesity, which are largely associated with low access to care in Black patient populations lead to disparate rates of preeclampsia in this population. Limited research shows an association between increased rate of preeclampsia in Black patients and specific APOL1, HLA-G, and PP13 gene polymorphisms as well as factor V Leiden mutations. Further research is required to understand the use of certain biomarkers in predicting preeclampsia within racial populations. Understanding contributing biosocial factors and identifying genes that may predispose high-risk populations may help to address the disparate rates of preeclampsia in Black patients as described in this review. Further research is required to understand if serum, placental, or urine biomarkers may be used to predict individuals at risk of developing preeclampsia in pregnancy. KEY POINTS: . Prevalence of preeclampsia in the U.S. is higher in Black patients compared to other racial groups.. . Patients with preeclampsia are at risk for poorer health outcomes both during and after delivery.. . Limited research suggests specific biomarkers or gene polymorphisms contribute to this difference; however, explanations for this disparity are multifactorial and further investigation is necessary.. Copyright Thieme. All rights reserved.
+Registry Number/Name of Substance
+ 0 (APOL1 protein, human). 0 (Apolipoprotein L1). 0 (Biomarkers). 9001-24-5 (Factor V). 0 (factor V Leiden).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1055%2fa-2008-7167
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Conklin&issn=0735-1631&title=American+Journal+of+Perinatology&atitle=Understanding+Health+Disparities+in+Preeclampsia%3A+A+Literature+Review.&volume=41&issue=01&spage=e1291&epage=e1300&date=2024&doi=10.1055%2Fa-2008-7167&pmid=36603833&sid=OVID:medline
+
+<28>
+Unique Identifier
+ 38560764
+Title
+ The dual GCGR/GLP-1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selection.
+Source
+ Diabetes, Obesity & Metabolism. 26(6):2368-2378, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Thomas L; Martel E; Rist W; Uphues I; Hamprecht D; Neubauer H; Augustin R
+Author NameID
+ Rist, Wolfgang; ORCID: https://orcid.org/0000-0002-0626-3544
+Authors Full Name
+ Thomas, Leo; Martel, Eric; Rist, Wolfgang; Uphues, Ingo; Hamprecht, Dieter; Neubauer, Heike; Augustin, Robert.
+Institution
+ Thomas, Leo. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Ribeta, Germany.
+ Martel, Eric. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Ribeta, Germany.
+ Rist, Wolfgang. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Ribeta, Germany.
+ Uphues, Ingo. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Ribeta, Germany.
+ Hamprecht, Dieter. Boehringer Ingelheim Research Italia, Milano, Italy.
+ Neubauer, Heike. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Ribeta, Germany.
+ Augustin, Robert. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Ribeta, Germany.
+MeSH Subject Headings
+ Animals
+ Receptors, Glucagon/ag [Agonists]
+ Receptors, Glucagon/ge [Genetics]
+ *Receptors, Glucagon
+ Mice
+ Glucagon-Like Peptide-1 Receptor/ag [Agonists]
+ Glucagon-Like Peptide-1 Receptor/me [Metabolism]
+ Glucagon-Like Peptide-1 Receptor/ge [Genetics]
+ *Glucagon-Like Peptide-1 Receptor
+ CHO Cells
+ Hypoglycemic Agents/pd [Pharmacology]
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ *Hypoglycemic Agents
+ Humans
+ *Cricetulus
+ Biomarkers/bl [Blood]
+ Male
+ Rats
+ Mice, Obese
+ Mice, Inbred C57BL
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+Keyword Heading
+ G-protein-coupled receptor, peptide
+ glucagon
+ glucagon-like peptide-1
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To describe the biomarker strategy that was applied to select survodutide (BI 456906), BI 456908 and BI 456897 from 19 dual glucagon receptor (GCGR)/ glucagon-like peptide-1 receptor (GLP-1R) agonists for in-depth pharmacological profiling, which led to the qualification of survodutide as the clinical development candidate.
+
+ MATERIALS AND METHODS: Potencies to increase cyclic adenosine monophosphate (cAMP) were determined in Chinese hamster ovary (CHO)-K1 cells stably expressing human GCGR and GLP-1R. Agonism for endogenously expressed receptors was investigated in insulinoma cells (MIN6) for mouse GLP-1R, and in rat primary hepatocytes for the GCGR. In vivo potencies to engage the GLP-1R or GCGR were determined, measuring improvement in oral glucose tolerance (30 nmol/kg) and increase in plasma fibroblast growth factor-21 (FGF21) and liver nicotinamide N-methyltransferase (NNMT) mRNA expression (100 nmol/kg), respectively. Body weight- and glucose-lowering efficacies were investigated in diet-induced obese (DIO) mice and diabetic db/db mice, respectively.
+
+ RESULTS: Upon acute dosing in lean mice, target engagement biomarkers for the GCGR and GLP-1R demonstrated a significant correlation (Spearman correlation coefficient with p < 0.05) to the in vitro GCGR and GLP-1R potencies for the 19 dual agonists investigated. Survodutide, BI 456908 and BI 456897 were selected for in-depth pharmacological profiling based on the significant improvement in acute oral glucose tolerance achieved (area under the curve [AUC] of 54%, 57% and 60% vs. vehicle) that was comparable to semaglutide (AUC of 45% vs. vehicle), while showing different degrees of in vivo GCGR engagement, as determined by hepatic NNMT mRNA expression (increased by 15- to 17-fold vs. vehicle) and plasma FGF21 concentrations (increased by up to sevenfold vs. vehicle). In DIO mice, survodutide (30 nmol/kg/once daily), BI 456908 (30 nmol/kg/once daily) and BI 456897 (10 nmol/kg/once daily) achieved a body weight-lowering efficacy from baseline of 25%, 27% and 26%, respectively. In db/db mice, survodutide and BI 456908 (10 and 20 nmol/kg/once daily) significantly lowered glycated haemoglobin (0.4%-0.6%); no significant effect was observed for BI 456897 (3 and 7 nmol/kg/once daily).
+
+ CONCLUSIONS: Survodutide was selected as the clinical candidate based on its balanced dual GCGR/GLP-1R pharmacology, engaging the GCGR for robust body weight-lowering efficacy exceeding that of selective GLP-1R agonists, while achieving antidiabetic efficacy that was comparable to selective GLP-1R agonism. Survodutide is currently being investigated in Phase 3 clinical trials in people living with obesity. Copyright © 2024 Boehringer Ingelheim Pharma GmbH & Co KG. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Receptors, Glucagon). 0 (Glucagon-Like Peptide-1 Receptor). 0 (Hypoglycemic Agents). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fdom.15551
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Thomas&issn=1462-8902&title=Diabetes%2C+Obesity+%26+Metabolism&atitle=The+dual+GCGR%2FGLP-1R+agonist+survodutide%3A+Biomarkers+and+pharmacological+profiling+for+clinical+candidate+selection.&volume=26&issue=6&spage=2368&epage=2378&date=2024&doi=10.1111%2Fdom.15551&pmid=38560764&sid=OVID:medline
+
+<29>
+Unique Identifier
+ 38788255
+Title
+ Study of non-alcoholic fatty pancreatic disease among the Egyptian population and the value of serum fatty acid binding protein-1 (FABP-1) as a non-invasive biomarker.
+Source
+ Clinics & Research in Hepatology & Gastroenterology. 48(6):102364, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Okasha HH; Hegazy MA; Shaker O; Elfatah YA; El-Sawy SS; Abdelfatah D; Abdellatef A
+Authors Full Name
+ Okasha, Hussein Hassan; Hegazy, Mona A; Shaker, Olfat; Elfatah, Yasmine Abd; El-Sawy, Shereen Sadik; Abdelfatah, Dalia; Abdellatef, Abeer.
+Institution
+ Okasha, Hussein Hassan. Internal Medicine Department, Division of Gastroenterology and Hepatology, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
+ Hegazy, Mona A. Internal Medicine Department, Division of Gastroenterology and Hepatology, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
+ Shaker, Olfat. Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Cairo University, Cairo, Egypt.
+ Elfatah, Yasmine Abd. Internal Medicine Department, DM and endocrinology Division, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
+ El-Sawy, Shereen Sadik. Internal Medicine Department, DM and endocrinology Division, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
+ Abdelfatah, Dalia. Cancer epidemiology and Biostatistics department, National Cancer Institute, Cairo University, Cairo, Egypt.
+ Abdellatef, Abeer. Internal Medicine Department, Division of Gastroenterology and Hepatology, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt. Electronic address: Abeerawad@kasralainy.edu.eg.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ Adult
+ Cross-Sectional Studies
+ Egypt/ep [Epidemiology]
+ Fatty Acid-Binding Proteins/bl [Blood]
+ *Fatty Acid-Binding Proteins
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Prospective Studies
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Pancreatic Diseases/bl [Blood]
+ Prevalence
+ Ultrasonography
+Keyword Heading
+ Fatty acid binding protein-1 (FABP1)
+ Fatty liver
+ Non-alcoholic fatty pancreas (NAFPD)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Non-alcoholic fatty pancreas disease (NAFPD) can be detected using various imaging techniques, but accurately measuring the amount of fat in the pancreas remains difficult. Fatty acid binding protein-1 (FABP-1) is a marker specific to certain tissues and can aid in diagnosing NAFPD. However, this study aimed to investigate the prevalence of NAFPD among obese and non-obese people with and without diabetes mellitus (DM). Additionally, it aimed to evaluate the associated risk factors for NAFPD and the utility of the FABP-1 level as a simple, non-invasive biomarker for diagnosing NAFPD.
+
+ METHODS: This study is a prospective cross-sectional study.
+
+ RESULTS: Ninety-five patients were enrolled in the study, comprising 35 males and 60 females, with a mean age of 44 years and a standard deviation (SD) of 11 years. However, 26.3 % were morbidly obese, 22.1 % were severely obese, 31.6 % were obese, 12.6 % were overweight, and 7.4 % were normal. Additionally, 35.8 % had diabetes mellitus, while 26.3 % of patients had hypertension. Regarding the ultrasonographic findings, 94.7 % of the patients had fatty liver, with the majority (41.1 %) classified as grade II, followed by 38.9 % classified as grade I, and 14.7 % classified as grade III fatty liver. Among these patients, 78.9 % had fatty pancreas, with 38.9 % classified as grade II, 31.6 % classified as grade I, and 8.4 % classified as grade III fatty pancreas. The median FABP-1 level among patients with fatty pancreas was 3.3 ng/ml, which exhibited a significant fair negative correlation with total bilirubin and a fair, positive correlation with alkaline phosphatase and portal vein diameter. A statistically substantial distinction was observed between the levels of AFABP-1 and the presence or grading of the fatty pancreas (p-value = 0.048 and < 0.001, respectively). Using multivariate analysis, FABP-1 was the only significant predictor of a fatty pancreas. The receiver operating characteristic (ROC) curve analysis indicated that at a cut-off point of FABP-1 of <= 3.7, it had a sensitivity of 58 %, specificity of 80 %, positive predictive value (PPV) of 96.6 %, negative predictive value (NPV) of 17 %, and an area under the curve (AUC) of 0.77.
+
+ CONCLUSION: NAFPD is becoming an increasingly significant challenge. FABP-1 can potentially be a straightforward and non-invasive predictor of the fatty pancreas. Copyright © 2024 Elsevier Masson SAS. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Fatty Acid-Binding Proteins). 0 (Biomarkers). 0 (FABP1 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.clinre.2024.102364
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Okasha&issn=2210-7401&title=Clinics+%26+Research+in+Hepatology+%26+Gastroenterology&atitle=Study+of+non-alcoholic+fatty+pancreatic+disease+among+the+Egyptian+population+and+the+value+of+serum+fatty+acid+binding+protein-1+%28FABP-1%29+as+a+non-invasive+biomarker.&volume=48&issue=6&spage=102364&epage=&date=2024&doi=10.1016%2Fj.clinre.2024.102364&pmid=38788255&sid=OVID:medline
+
+<30>
+Unique Identifier
+ 37957519
+Title
+ Relationship Between Zinc, Selenium, and Magnesium Status and Markers of Metabolically Healthy and Unhealthy Obesity Phenotypes.
+Source
+ Biological Trace Element Research. 202(8):3449-3464, 2024 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cruz KJC; de Oliveira ARS; Fontenelle LC; Morais JBS; de Sousa Melo SR; Dos Santos LR; de Sousa TGV; de Freitas ST; Henriques GS; Bordin S; Maia CSC; de Oliveira FE; Costa CHN; de Matos Neto EM; do Nascimento Marreiro D
+Author NameID
+ Cruz, Kyria Jayanne Climaco; ORCID: http://orcid.org/0000-0002-4489-702X
+ de Oliveira, Ana Raquel Soares; ORCID: http://orcid.org/0000-0001-5383-0137
+ Fontenelle, Larissa Cristina; ORCID: http://orcid.org/0000-0003-0156-6105
+ de Sousa Melo, Stefany Rodrigues; ORCID: http://orcid.org/0000-0001-5308-3522
+ Dos Santos, Loanne Rocha; ORCID: http://orcid.org/0000-0002-5418-6715
+ de Sousa, Thayanne Gabryelle Visgueira; ORCID: http://orcid.org/0000-0002-9065-4504
+ de Freitas, Suelem Torres; ORCID: http://orcid.org/0000-0002-2146-2840
+ Henriques, Gilberto Simeone; ORCID: http://orcid.org/0000-0002-9110-5427
+ Bordin, Silvana; ORCID: http://orcid.org/0000-0002-0192-8869
+ Maia, Carla Soraya Costa; ORCID: http://orcid.org/0000-0003-1535-6686
+ de Oliveira, Francisco Erasmo; ORCID: http://orcid.org/0000-0001-9941-3419
+ Costa, Carlos Henrique Nery; ORCID: http://orcid.org/0000-0001-7302-2006
+ de Matos Neto, Emidio Marques; ORCID: http://orcid.org/0000-0002-5635-900X
+ do Nascimento Marreiro, Dilina; ORCID: http://orcid.org/0000-0002-7550-1403
+Authors Full Name
+ Cruz, Kyria Jayanne Climaco; de Oliveira, Ana Raquel Soares; Fontenelle, Larissa Cristina; Morais, Jennifer Beatriz Silva; de Sousa Melo, Stefany Rodrigues; Dos Santos, Loanne Rocha; de Sousa, Thayanne Gabryelle Visgueira; de Freitas, Suelem Torres; Henriques, Gilberto Simeone; Bordin, Silvana; Maia, Carla Soraya Costa; de Oliveira, Francisco Erasmo; Costa, Carlos Henrique Nery; de Matos Neto, Emidio Marques; do Nascimento Marreiro, Dilina.
+Institution
+ Cruz, Kyria Jayanne Climaco. Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil.
+ de Oliveira, Ana Raquel Soares. Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil.
+ Fontenelle, Larissa Cristina. Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil.
+ Morais, Jennifer Beatriz Silva. Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil.
+ de Sousa Melo, Stefany Rodrigues. Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil.
+ Dos Santos, Loanne Rocha. Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil.
+ de Sousa, Thayanne Gabryelle Visgueira. Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil. thayanne_visgueira@hotmail.com.
+ de Freitas, Suelem Torres. Planning and Institucional Development, Federal University of Para, Belem, Para, Brazil.
+ Henriques, Gilberto Simeone. School of Nursing, Federal University of Minas Gerais, 6627 Pres. Antonio Carlos Ave. Pampulha, Belo Horizonte, Minas Gerais, Brazil.
+ Bordin, Silvana. University of Sao Paulo, Sao Paulo, Brazil.
+ Maia, Carla Soraya Costa. State University of Ceara, Fortaleza, Ceara, Brazil.
+ de Oliveira, Francisco Erasmo. Clinical Laboratory, Teresina, Piaui, Brazil.
+ Costa, Carlos Henrique Nery. Department of Community Medicine, Federal University of Piaui, Teresina, Brazil.
+ de Matos Neto, Emidio Marques. Department of Physical Education, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil.
+ do Nascimento Marreiro, Dilina. Department of Nutrition, Federal University of Piaui, Campus Minister Petronio Portela, Ininga, Teresina, Piaui, Brazil.
+MeSH Subject Headings
+ Humans
+ Selenium/bl [Blood]
+ Selenium/ur [Urine]
+ *Selenium
+ Female
+ Magnesium/bl [Blood]
+ Magnesium/ur [Urine]
+ *Magnesium
+ Zinc/bl [Blood]
+ Zinc/ur [Urine]
+ *Zinc
+ Adult
+ Obesity/bl [Blood]
+ Obesity/ur [Urine]
+ *Obesity
+ Cross-Sectional Studies
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ *Biomarkers
+ Middle Aged
+ Phenotype
+ Body Mass Index
+Keyword Heading
+ Magnesium
+ Metabolically Healthy Obesity
+ Obesity
+ Selenium
+ Zinc
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Our objective was to investigate the relationship between zinc, selenium, and magnesium status and markers of metabolically healthy and unhealthy obesity phenotypes. This was a cross-sectional study with 140 women: metabolically healthy obese women (n = 35), metabolically unhealthy obese women (n = 28), and normal-weight women (n = 77). We have calculated the body mass index, waist-hip ratio, waist-height ratio and some adiposity indices. Additionally, we evaluated endocrine-metabolic parameters and estimated the dietary intake of energy, macronutrients, zinc, selenium, and magnesium. The mineral concentrations in plasma, erythrocytes, and urine were assessed. In obese patients, there was a significant decrease in dietary zinc, selenium, and magnesium intake per kilogram of body weight, as well as lower mineral concentrations in both plasma and erythrocytes. Additionally, these patients exhibited higher urinary mineral levels compared to the control group, regardless of whether they had healthy or unhealthy phenotypes. We observed a significant correlation between deficiencies in zinc, selenium, and magnesium and obesity-associated metabolic disorders, including dyslipidemias and redox status disturbances. This study highlights a connection between deficiencies in zinc, selenium, and magnesium and metabolic disorders linked to obesity, including dyslipidemias, alterations in redox status, and thyroid hormonal dysfunction. Copyright © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ H6241UJ22B (Selenium). I38ZP9992A (Magnesium). J41CSQ7QDS (Zinc). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs12011-023-03938-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cruz&issn=0163-4984&title=Biological+Trace+Element+Research&atitle=Relationship+Between+Zinc%2C+Selenium%2C+and+Magnesium+Status+and+Markers+of+Metabolically+Healthy+and+Unhealthy+Obesity+Phenotypes.&volume=202&issue=8&spage=3449&epage=3464&date=2024&doi=10.1007%2Fs12011-023-03938-z&pmid=37957519&sid=OVID:medline
+
+<31>
+Unique Identifier
+ 38813831
+Title
+ Diagnosis and non-invasive assessment of MASLD in type 2 diabetes and obesity. [Review]
+Source
+ Alimentary Pharmacology & Therapeutics. 59 Suppl 1:S23-S40, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chan WK; Petta S; Noureddin M; Goh GBB; Wong VW
+Author NameID
+ Chan, Wah-Kheong; ORCID: https://orcid.org/0000-0002-9105-5837
+ Petta, Salvatore; ORCID: https://orcid.org/0000-0002-0822-9673
+ Noureddin, Mazen; ORCID: https://orcid.org/0000-0003-2127-2040
+ Wong, Vincent Wai-Sun; ORCID: https://orcid.org/0000-0003-2215-9410
+Authors Full Name
+ Chan, Wah-Kheong; Petta, Salvatore; Noureddin, Mazen; Goh, George Boon Bee; Wong, Vincent Wai-Sun.
+Institution
+ Chan, Wah-Kheong. Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
+ Petta, Salvatore. Sezione di Gastroenterologia, PROMISE, University of Palermo, Palermo, Italy.
+ Petta, Salvatore. Department of Economics and Statistics, University of Palermo, Palermo, Italy.
+ Noureddin, Mazen. Houston Methodist Hospital, Houston Research Institute, Houston, Texas, USA.
+ Goh, George Boon Bee. Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
+ Goh, George Boon Bee. Medicine Academic Clinical Program, Duke-NUS Medical School, Singapore.
+ Wong, Vincent Wai-Sun. Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
+ Wong, Vincent Wai-Sun. State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2
+ Obesity/co [Complications]
+ *Obesity
+ Ultrasonography/mt [Methods]
+ Magnetic Resonance Imaging/mt [Methods]
+ Elasticity Imaging Techniques/mt [Methods]
+ Fatty Liver/di [Diagnosis]
+ Fatty Liver/dg [Diagnostic Imaging]
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/dg [Diagnostic Imaging]
+ Biomarkers/bl [Blood]
+Abstract
+ BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic liver disease and an important cause of cirrhosis and hepatocellular carcinoma. It is strongly associated with type 2 diabetes and obesity. Because of the huge number of patients at risk of MASLD, it is imperative to use non-invasive tests appropriately.
+
+ AIMS: To provide a narrative review on the performance and limitations of non-invasive tests, with a special emphasis on the impact of diabetes and obesity.
+
+ METHODS: We searched PubMed and Cochrane databases for articles published from 1990 to August 2023.
+
+ RESULTS: Abdominal ultrasonography remains the primary method to diagnose hepatic steatosis, while magnetic resonance imaging proton density fat fraction is currently the gold standard to quantify steatosis. Simple fibrosis scores such as the Fibrosis-4 index are well suited as initial assessment in primary care and non-hepatology settings to rule out advanced fibrosis and future risk of liver-related complications. However, because of its low positive predictive value, an abnormal test should be followed by specific blood (e.g. Enhanced Liver Fibrosis score) or imaging biomarkers (e.g. vibration-controlled transient elastography and magnetic resonance elastography) of fibrosis. Some non-invasive tests of fibrosis appear to be less accurate in patients with diabetes. Obesity also affects the performance of abdominal ultrasonography and transient elastography, whereas magnetic resonance imaging may not be feasible in some patients with severe obesity.
+
+ CONCLUSIONS: This article highlights issues surrounding the clinical application of non-invasive tests for MASLD in patients with type 2 diabetes and obesity. Copyright © 2024 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fapt.17866
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chan&issn=0269-2813&title=Alimentary+Pharmacology+%26+Therapeutics&atitle=Diagnosis+and+non-invasive+assessment+of+MASLD+in+type+2+diabetes+and+obesity.&volume=59&issue=1&spage=S23&epage=S40&date=2024&doi=10.1111%2Fapt.17866&pmid=38813831&sid=OVID:medline
+
+<32>
+Unique Identifier
+ 38374352
+Title
+ Effects of resveratrol on the anthropometric indices and inflammatory markers: an umbrella meta-analysis.
+Source
+ European Journal of Nutrition. 63(4):1023-1040, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Molani-Gol R; Rafraf M
+Author NameID
+ Rafraf, Maryam; ORCID: http://orcid.org/0000-0002-2593-1253
+Authors Full Name
+ Molani-Gol, Roghayeh; Rafraf, Maryam.
+Institution
+ Molani-Gol, Roghayeh. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Molani-Gol, Roghayeh. Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Rafraf, Maryam. Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. rafrafm@tbzmed.ac.ir.
+MeSH Subject Headings
+ Humans
+ Anthropometry/mt [Methods]
+ Anti-Inflammatory Agents/pd [Pharmacology]
+ Anti-Inflammatory Agents/ad [Administration & Dosage]
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ Dietary Supplements
+ Inflammation/bl [Blood]
+ Inflammation/dt [Drug Therapy]
+ *Inflammation
+ Obesity/bl [Blood]
+ Randomized Controlled Trials as Topic
+ Resveratrol/pd [Pharmacology]
+ Resveratrol/ad [Administration & Dosage]
+ *Resveratrol
+ Waist Circumference/de [Drug Effects]
+Keyword Heading
+ Anthropometric indices
+ Inflammation
+ Obesity
+ Resveratrol
+ Umbrella meta-analysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The evidence for resveratrol's anti-obesity and anti-inflammatory qualities is accumulating, though meta-analyses have reported mixed results. The current umbrella meta-analysis aimed to assess the present evidence and provide an accurate estimate of the overall effects of resveratrol on the anthropometric indices and inflammatory markers.
+
+ METHOD: The Web of Science, PubMed, Scopus, and Google Scholar databases were searched till March 2023. The meta-analysis was performed utilizing a random-effects model. Moreover, the overall strength and quality of the evidence were assessed using the GRADE tool.
+
+ RESULTS: The results from 19 meta-analyses investigating 81 unique randomized controlled trials with 4088 participants revealed that resveratrol supplementation reduced the body mass index (ES = - 0.119, 95% CI (- 0.192, - 0.047), p = 0.001), waist circumference (ES = - 0.405, 95% CI [- 0.664, - 0.147], p = 0.002), serum levels of C-reactive protein (ES = - 0.390, 95% CI [- 0.474, - 0.306], p < 0.001), and tumor necrosis factor-alpha (ES = - 0.455, 95% CI [- 0.592, - 0.318], p < 0.001) in comparison to the control group. The effects of resveratrol on body weight and Interleukin-6 levels of participants were not significant. However, resveratrol administration significantly decreased body weight in trials with intervention duration >= 12 weeks [ES = - 0.160, 95% CI (- 0.268, - 0.052)] and supplement dosage >= 500 mg/day [ES = - 0.130, 95% CI (- 0.238, - 0.022)].
+
+ CONCLUSION: The findings suggest the beneficial effects of resveratrol supplementation on reducing general and central obesity, as well as decreasing some inflammatory markers. Nevertheless, further high-quality research is required to prove these achievements and also evaluate resveratrol's effects on other inflammatory markers. Copyright © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
+Registry Number/Name of Substance
+ 0 (Anti-Inflammatory Agents). 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). Q369O8926L (Resveratrol).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs00394-024-03335-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Molani-Gol&issn=1436-6207&title=European+Journal+of+Nutrition&atitle=Effects+of+resveratrol+on+the+anthropometric+indices+and+inflammatory+markers%3A+an+umbrella+meta-analysis.&volume=63&issue=4&spage=1023&epage=1040&date=2024&doi=10.1007%2Fs00394-024-03335-9&pmid=38374352&sid=OVID:medline
+
+<33>
+Unique Identifier
+ 38802439
+Title
+ Evaluating the impact of exercise on intermediate disease markers in overweight and obese individuals through a network meta-analysis of randomized controlled trials.
+Source
+ Scientific Reports. 14(1):12137, 2024 05 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu Y; Wang X; Fang Z
+Authors Full Name
+ Liu, Yuanyuan; Wang, Xianzi; Fang, Zilong.
+Institution
+ Liu, Yuanyuan. School of Sports Medicine and Rehabilitation, Beijing Sport University, Haidian District, Beijing, 100084, China.
+ Wang, Xianzi. School of Computer Science, Anhui University of Technology, Huashan District, Ma'anshan City, 243002, China.
+ Fang, Zilong. School of Sports Medicine and Rehabilitation, Beijing Sport University, Haidian District, Beijing, 100084, China. fangzilong@bsu.edu.cn.
+MeSH Subject Headings
+ Humans
+ Obesity/th [Therapy]
+ Obesity/bl [Blood]
+ *Obesity
+ *Randomized Controlled Trials as Topic
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Exercise/ph [Physiology]
+ *Exercise
+ Overweight/th [Therapy]
+ Overweight/bl [Blood]
+ *Overweight
+ Network Meta-Analysis
+ Male
+ Exercise Therapy/mt [Methods]
+ Glycated Hemoglobin/me [Metabolism]
+ Triglycerides/bl [Blood]
+ Female
+ Resistance Training
+Keyword Heading
+ Exercise
+ Intermediate disease markers
+ Network meta-analysis
+ Overweight and obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The aim of this study is to investigate the impact of exercise on intermediate disease markers in populations with overweight and obesity, providing evidence-based recommendations for clinicians to utilize these markers in developing exercise prescriptions for this group. The study was conducted by retrieving data from PubMed, Embase, Cochrane Library, Web of Science, and CNKI and only including Randomized Controlled Trials (RCTs) to examine the effect of different exercise interventions on intermediate disease markers in overweight and obese people. The quality of the included studies was evaluated using the Cochrane Bias Risk Assessment tool and the data was analyzed using Stata 15.1 data analysis software. The RCTs were collected from January 2017 to March 2024. A total of 56 RCTs were included and the results of 10 outcomes were analyzed using random effects meta-analysis. The total sample size used in the study was 3193 The results showed that resistance training significantly reduced total cholesterol (SUCRA: 99.9%), triglycerides (SUCRA: 100.0%), low-density lipoprotein (SUCRA: 100.0%), systolic pressure (SUCRA: 92.5%), and increased high-density lipoprotein (SUCRA: 100.0%). Aerobic exercise significantly reduced insulin (SUCRA: 89.1%) and HbA1c (SUCRA: 95.3%). Concurrent training significantly reduced HOMA-IR (SUCRA: 93.8%), diastolic blood pressure (SUCRA: 71.2%) and Glucose (SUCRA: 87.6%). Exercise has a significant impact on intermediate disease markers in populations with overweight and obese. Compared with no exercise, exercise lowers total cholesterol, triglycerides, LDL, systolic blood pressure, diastolic blood pressure, HOMA-IR, insulin, and HbA1c, and increases HDL in people with overweight and obese. These findings provide evidence-based recommendations for exercise interventions aimed at weight reduction and the prevention of chronic diseases in individuals with overweight and obese. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin). 0 (Triglycerides).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1038%2fs41598-024-62677-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=2045-2322&title=Scientific+Reports&atitle=Evaluating+the+impact+of+exercise+on+intermediate+disease+markers+in+overweight+and+obese+individuals+through+a+network+meta-analysis+of+randomized+controlled+trials.&volume=14&issue=1&spage=12137&epage=&date=2024&doi=10.1038%2Fs41598-024-62677-w&pmid=38802439&sid=OVID:medline
+
+<34>
+Unique Identifier
+ 38574896
+Title
+ Diagnostic performance of the GGT/HDL-C ratio for NAFLD in adults with obesity undergoing bariatric surgery.
+Source
+ Diabetes Research & Clinical Practice. 211:111649, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pajuelo-Vasquez R; Benites-Meza JK; Durango-Chavez HV; Salinas-Sedo G; Toro-Huamanchumo CJ
+Authors Full Name
+ Pajuelo-Vasquez, Renzo; Benites-Meza, Jerry K; Durango-Chavez, Hilda V; Salinas-Sedo, Gustavo; Toro-Huamanchumo, Carlos J.
+Institution
+ Pajuelo-Vasquez, Renzo. CHANGE Research Working Group, Facultad de Ciencias de la Salud, Carrera de Medicina Humana, Universidad Cientifica del Sur, Lima, Peru.
+ Benites-Meza, Jerry K. Sociedad Cientifica de Estudiantes de Medicina de la Universidad Nacional de Trujillo, Trujillo, Peru; Grupo Peruano de Investigacion Epidemiologica, Unidad de Investigacion para la Generacion y Sintesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru.
+ Durango-Chavez, Hilda V. School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
+ Salinas-Sedo, Gustavo. Clinica Avendano, Lima, Peru.
+ Toro-Huamanchumo, Carlos J. OBEMET Center for Obesity and Metabolic Health, Lima, Peru; Unidad de Investigacion para la Generacion y Sintesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru; Nutrition and Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Electronic address: toro2993@gmail.com.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Female
+ Male
+ gamma-Glutamyltransferase/bl [Blood]
+ *gamma-Glutamyltransferase
+ *Bariatric Surgery
+ Cross-Sectional Studies
+ Adult
+ Middle Aged
+ Cholesterol, HDL/bl [Blood]
+ *Cholesterol, HDL
+ Obesity/co [Complications]
+ Obesity/bl [Blood]
+ Obesity/su [Surgery]
+ *Obesity
+ Biomarkers/bl [Blood]
+Keyword Heading
+ Diagnosis
+ HDL-Cholesterol
+ Non-alcoholic fatty liver disease
+ gamma-Glutamiltransferase
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has become the most frequent liver disease, closely related with metabolic risk factors such as obesity, insulin resistance, dyslipidemia, diabetes mellitus, and metabolic syndrome. In this context, gamma-Glutamyl transpeptidase (GGT) and high-density lipoprotein cholesterol (HDL-C) have shown correlations with steatosis severity and metabolic syndrome, respectively. This positions the GGT/HDL-C ratio as a potential diagnostic indicator for NAFLD.
+
+ OBJECTIVE: To assess the diagnostic performance of the GGT/HDL-C ratio for NAFLD in adults with obesity undergoing bariatric surgery.
+
+ METHODS: We conducted an analytical cross-sectional study, designed as a diagnostic test evaluation. A secondary database of 249 adults with obesity was analyzed. The optimal cut-off point was ascertained using three methodologies, and five adjustment models were constructed for the total population, further stratified by sex.
+
+ RESULTS: The optimal cut-off point was 20.5 U/mmol and the AUC of the ratio was 0.81 (95% CI: 0.64-0.98), with sensitivity and specificity being 82.5% and 77.8%, respectively. In the overall group with an elevated GGT/HDL-C ratio, the prevalence of NAFLD increased by 14% (PR: 1.14; 95% CI: 1.04-1.33). Specifically, women displaying this altered ratio showed a 19% increased prevalence (PR: 1.19; 95% CI: 1.07-1.42) compared to those with normal values.
+
+ CONCLUSIONS: The GGT/HDL-C ratio is a promising biomarker for the diagnosis of NAFLD in an adult population living with obesity. Copyright © 2024 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ EC 2-3-2-2 (gamma-Glutamyltransferase). 0 (Cholesterol, HDL). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.diabres.2024.111649
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pajuelo-Vasquez&issn=0168-8227&title=Diabetes+Research+%26+Clinical+Practice&atitle=Diagnostic+performance+of+the+GGT%2FHDL-C+ratio+for+NAFLD+in+adults+with+obesity+undergoing+bariatric+surgery.&volume=211&issue=&spage=111649&epage=&date=2024&doi=10.1016%2Fj.diabres.2024.111649&pmid=38574896&sid=OVID:medline
+
+<35>
+Unique Identifier
+ 38742409
+Title
+ Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea.
+Source
+ Circulation: Heart Failure. 17(5):e011366, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kosyakovsky LB; Liu EE; Wang JK; Myers L; Parekh JK; Knauss H; Lewis GD; Malhotra R; Nayor M; Robbins JM; Gerszten RE; Hamburg NM; McNeill JN; Lau ES; Ho JE
+Author NameID
+ Kosyakovsky, Leah B; ORCID: https://orcid.org/0000-0003-2482-0444
+ Wang, Jessica K; ORCID: https://orcid.org/0000-0003-1421-4969
+ Parekh, Juhi K; ORCID: https://orcid.org/0009-0009-6510-0073
+ Lewis, Gregory D; ORCID: https://orcid.org/0000-0001-8108-8240
+ Malhotra, Rajeev; ORCID: https://orcid.org/0000-0003-0120-4630
+ Nayor, Matthew; ORCID: https://orcid.org/0000-0002-6993-9396
+ Robbins, Jeremy M; ORCID: https://orcid.org/0000-0002-9672-4841
+ Gerszten, Robert E; ORCID: https://orcid.org/0000-0002-6767-7687
+ Hamburg, Naomi M; ORCID: https://orcid.org/0000-0001-5504-5589
+ Lau, Emily S; ORCID: https://orcid.org/0000-0001-9361-6397
+ Ho, Jennifer E; ORCID: https://orcid.org/0000-0002-7987-4768
+Authors Full Name
+ Kosyakovsky, Leah B; Liu, Elizabeth E; Wang, Jessica K; Myers, Lisa; Parekh, Juhi K; Knauss, Hanna; Lewis, Gregory D; Malhotra, Rajeev; Nayor, Matthew; Robbins, Jeremy M; Gerszten, Robert E; Hamburg, Naomi M; McNeill, Jenna N; Lau, Emily S; Ho, Jennifer E.
+Institution
+ Kosyakovsky, Leah B. Division of Cardiology (L.B.K., E.E.L., J.K.W., J.K.P., J.M.R., R.E.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
+ Liu, Elizabeth E. Division of Cardiology (L.B.K., E.E.L., J.K.W., J.K.P., J.M.R., R.E.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
+ Wang, Jessica K. Division of Cardiology (L.B.K., E.E.L., J.K.W., J.K.P., J.M.R., R.E.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
+ Myers, Lisa. Division of Cardiology, Massachusetts General Hospital, Boston (L.M., G.D.L., R.M., E.S.L.).
+ Parekh, Juhi K. Division of Cardiology (L.B.K., E.E.L., J.K.W., J.K.P., J.M.R., R.E.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
+ Knauss, Hanna. Department of Medicine (H.K.), Beth Israel Deaconess Medical Center, Boston, MA.
+ Lewis, Gregory D. Division of Cardiology, Massachusetts General Hospital, Boston (L.M., G.D.L., R.M., E.S.L.).
+ Malhotra, Rajeev. Division of Cardiology, Massachusetts General Hospital, Boston (L.M., G.D.L., R.M., E.S.L.).
+ Nayor, Matthew. Sections of Cardiology and Preventive Medicine and Epidemiology, Division of Internal Medicine, Boston University School of Medicine, MA (M.N.).
+ Robbins, Jeremy M. Division of Cardiology (L.B.K., E.E.L., J.K.W., J.K.P., J.M.R., R.E.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
+ Gerszten, Robert E. Division of Cardiology (L.B.K., E.E.L., J.K.W., J.K.P., J.M.R., R.E.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
+ Hamburg, Naomi M. Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University Chobanian and Avedisian School of Medicine, MA (N.M.H.).
+ McNeill, Jenna N. Division of Pulmonary and Critical Care Medicine, Duke University, Durham, NC (J.N.M.).
+ Lau, Emily S. Division of Cardiology, Massachusetts General Hospital, Boston (L.M., G.D.L., R.M., E.S.L.).
+ Ho, Jennifer E. Division of Cardiology (L.B.K., E.E.L., J.K.W., J.K.P., J.M.R., R.E.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
+MeSH Subject Headings
+ Humans
+ Female
+ Heart Failure/pp [Physiopathology]
+ Heart Failure/di [Diagnosis]
+ *Heart Failure
+ Male
+ Middle Aged
+ Stroke Volume/ph [Physiology]
+ *Stroke Volume
+ Dyspnea/pp [Physiopathology]
+ *Dyspnea
+ Obesity/pp [Physiopathology]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ *Obesity
+ *Exercise Test
+ Aged
+ Echocardiography
+ Adult
+ Natriuretic Peptide, Brain/bl [Blood]
+ Peptide Fragments/bl [Blood]
+ Pulmonary Wedge Pressure/ph [Physiology]
+ Ventricular Function, Left/ph [Physiology]
+ Biomarkers/bl [Blood]
+ Prevalence
+Keyword Heading
+ cardiovascular diseases
+ echocardiography
+ exercise test
+ heart failure
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although heart failure with preserved ejection fraction (HFpEF) has become the predominant heart failure subtype, it remains clinically under-recognized. HFpEF diagnosis is particularly challenging in the setting of obesity given the limitations of natriuretic peptides and resting echocardiography. We examined invasive and noninvasive HFpEF diagnostic criteria among individuals with obesity and dyspnea without known cardiovascular disease to determine the prevalence of hemodynamic HFpEF in the community.
+
+ METHODS: Research volunteers with dyspnea and obesity underwent resting echocardiography; participants with possible pulmonary hypertension qualified for invasive cardiopulmonary exercise testing. HFpEF was defined using rest or exercise pulmonary capillary wedge pressure criteria (>=15 mm Hg or DELTApulmonary capillary wedge pressure/DELTAcardiac output slope, >2.0 mm Hg.L-1.min-1).
+
+ RESULTS: Among n=78 participants (age, 53+/-13 years; 65% women; body mass index, 37.3+/-6.8 kg/m2), 40 (51%) met echocardiographic criteria to undergo invasive cardiopulmonary exercise testing. In total, 24 participants (60% among the cardiopulmonary exercise testing group, 31% among the total sample) were diagnosed with HFpEF by rest or exercise pulmonary capillary wedge pressure (n=12) or exercise criteria (n=12). There were no differences in NT-proBNP (N-terminal pro-B-type natriuretic peptide; 79 [62-104] versus 73 [57-121] pg/mL) or resting echocardiography (mitral E/e' ratio, 9.1+/-3.1 versus 8.0+/-2.7) among those with versus without HFpEF (P>0.05 for all). Distributions of HFpEF diagnostic scores were similar, with the majority classified as intermediate risk (100% versus 93.75% [H2FPEF] and 87.5% versus 68.75% [HFA-PEFF (Heart Failure Association Pretest assessment, echocardiography and natriuretic peptide, functional testing, and final etiology)] in those with versus without HFpEF).
+
+ CONCLUSIONS: Among adults with obesity and dyspnea without known cardiovascular disease, at least a third had clinically unrecognized HFpEF uncovered on invasive cardiopulmonary exercise testing. Clinical, biomarker, resting echocardiography, and diagnostic scores were similar among those with and without HFpEF. These results suggest clinical underdiagnosis of HFpEF among individuals with obesity and dyspnea and highlight limitations of noninvasive testing in the identification of HFpEF.
+Registry Number/Name of Substance
+ 0 (pro-brain natriuretic peptide (1-76)).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1161%2fCIRCHEARTFAILURE.123.011366
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kosyakovsky&issn=1941-3289&title=Circulation%3A+Heart+Failure&atitle=Uncovering+Unrecognized+Heart+Failure+With+Preserved+Ejection+Fraction+Among+Individuals+With+Obesity+and+Dyspnea.&volume=17&issue=5&spage=e011366&epage=&date=2024&doi=10.1161%2FCIRCHEARTFAILURE.123.011366&pmid=38742409&sid=OVID:medline
+
+<36>
+Unique Identifier
+ 38664310
+Title
+ Obesity-related inflammatory protein signature in cardiovascular clinical outcomes: results from the Gutenberg Health Study.
+Source
+ Obesity. 32(6):1198-1209, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Panova-Noeva M; Koeck T; Schoelch C; Schulz A; Prochaska JH; Michal M; Strauch K; Schuster AK; Lackner KJ; Munzel T; Hennige AM; Wild PS
+Author NameID
+ Panova-Noeva, Marina; ORCID: https://orcid.org/0000-0003-2155-8030
+Authors Full Name
+ Panova-Noeva, Marina; Koeck, Thomas; Schoelch, Corinna; Schulz, Andreas; Prochaska, Jurgen H; Michal, Matthias; Strauch, Konstantin; Schuster, Alexander K; Lackner, Karl J; Munzel, Thomas; Hennige, Anita M; Wild, Philipp S.
+Institution
+ Panova-Noeva, Marina. Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany.
+ Panova-Noeva, Marina. Center for Thrombosis and Haemostasis, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Koeck, Thomas. Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Koeck, Thomas. German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.
+ Schoelch, Corinna. Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
+ Schulz, Andreas. Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Prochaska, Jurgen H. Center for Thrombosis and Haemostasis, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Prochaska, Jurgen H. Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Prochaska, Jurgen H. German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.
+ Michal, Matthias. German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.
+ Michal, Matthias. Department of Psychosomatic Medicine and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Strauch, Konstantin. Institute for Medical Biometrics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Schuster, Alexander K. Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Lackner, Karl J. German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.
+ Lackner, Karl J. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Munzel, Thomas. Center for Thrombosis and Haemostasis, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Munzel, Thomas. German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.
+ Munzel, Thomas. Department of Cardiology-Cardiology I, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Hennige, Anita M. Therapeutic Area CardioMetabolism & Respiratory, Boehringer Ingelheim International GmbH, Biberach, Germany.
+ Wild, Philipp S. Center for Thrombosis and Haemostasis, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Wild, Philipp S. Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
+ Wild, Philipp S. German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.
+ Wild, Philipp S. Institute of Molecular Biology (IMB), Mainz, Germany.
+MeSH Subject Headings
+ Humans
+ Female
+ Male
+ Obesity/co [Complications]
+ *Obesity
+ Middle Aged
+ *Cardiovascular Diseases
+ *Inflammation
+ Aged
+ Body Mass Index
+ Biomarkers/bl [Blood]
+ Risk Factors
+ Adult
+ Overweight/co [Complications]
+Abstract
+ OBJECTIVE: The objective of this study was to investigate whether an obesity-related inflammatory protein signature (OIPS) is associated with adverse cardiovascular events.
+
+ METHODS: The Olink Target 96 Inflammation panel was performed in 6662 participants from the population-based Gutenberg Health Study (GHS). The OIPS was selected by a logistic regression model, and its association with cardiovascular outcomes was evaluated by Cox regression analysis. The GHS-derived OIPS was externally validated in the MyoVasc study.
+
+ RESULTS: The identified OIPS entailed 21 proteins involved in chemokine activity, tumor necrosis factor (TNF) receptor binding, and growth factor receptor binding. The signature revealed a novel positive association of axis inhibition protein 1 with obesity. The OIPS was associated with increased risk of all-cause and cardiac deaths, major adverse cardiovascular events, and incident coronary artery disease, independent of clinical covariates and established risk instruments. A BMI-stratified analysis confirmed the association of OIPS with increased death in those with obesity and overweight and with increased risk for coronary artery disease in those with obesity. The association of OIPS with increased risk of all-cause and cardiac deaths was validated in the MyoVasc cohort.
+
+ CONCLUSIONS: The OIPS showed a significant association with adverse clinical outcomes, particularly in those with overweight and obesity, and represents a promising tool for identifying patients at higher risk for worse cardiovascular outcomes. Copyright © 2024 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1002%2foby.24014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Panova-Noeva&issn=1930-7381&title=Obesity&atitle=Obesity-related+inflammatory+protein+signature+in+cardiovascular+clinical+outcomes%3A+results+from+the+Gutenberg+Health+Study.&volume=32&issue=6&spage=1198&epage=1209&date=2024&doi=10.1002%2Foby.24014&pmid=38664310&sid=OVID:medline
+
+<37>
+Unique Identifier
+ 38396126
+Title
+ Supplementation with antioxidant micronutrients in pregnant women with obesity: a randomized controlled trial.
+Source
+ International Journal of Obesity. 48(6):796-807, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sen S; Cherkerzian S; Herlihy M; Hacker MR; McElrath TF; Cantonwine DE; Fichorova R; Oken E; Meydani SN
+Author NameID
+ Sen, Sarbattama; ORCID: http://orcid.org/0000-0003-0138-7668
+Authors Full Name
+ Sen, Sarbattama; Cherkerzian, Sara; Herlihy, Mary; Hacker, Michele R; McElrath, Thomas F; Cantonwine, David E; Fichorova, Raina; Oken, Emily; Meydani, Simin N.
+Institution
+ Sen, Sarbattama. Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA. Ssen2@bwh.harvard.edu.
+ Sen, Sarbattama. JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. Ssen2@bwh.harvard.edu.
+ Sen, Sarbattama. Harvard Medical School, Boston, MA, USA. Ssen2@bwh.harvard.edu.
+ Cherkerzian, Sara. Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.
+ Cherkerzian, Sara. Harvard Medical School, Boston, MA, USA.
+ Herlihy, Mary. Harvard Medical School, Boston, MA, USA.
+ Herlihy, Mary. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
+ Hacker, Michele R. Harvard Medical School, Boston, MA, USA.
+ Hacker, Michele R. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
+ McElrath, Thomas F. Harvard Medical School, Boston, MA, USA.
+ McElrath, Thomas F. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.
+ Cantonwine, David E. Harvard Medical School, Boston, MA, USA.
+ Cantonwine, David E. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.
+ Fichorova, Raina. Harvard Medical School, Boston, MA, USA.
+ Fichorova, Raina. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.
+ Oken, Emily. Harvard Medical School, Boston, MA, USA.
+ Oken, Emily. Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
+ Meydani, Simin N. JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
+MeSH Subject Headings
+ Humans
+ Female
+ Pregnancy
+ Double-Blind Method
+ Micronutrients/ad [Administration & Dosage]
+ *Micronutrients
+ Antioxidants/ad [Administration & Dosage]
+ *Antioxidants
+ *Dietary Supplements
+ Adult
+ Oxidative Stress/de [Drug Effects]
+ *Oxidative Stress
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Pregnancy Complications/bl [Blood]
+ Pregnancy Complications/dt [Drug Therapy]
+ Biomarkers/bl [Blood]
+Abstract
+ BACKGROUND/OBJECTIVE: Obesity increases maternal morbidity and adversely affects child health. Maternal inflammation may play a role in adverse outcomes. The objective of this study was to determine whether providing a higher dose of antioxidant micronutrients to pregnant women with obesity would raise concentrations of key antioxidant vitamins and impact inflammation and oxidative stress during pregnancy.
+
+ SUBJECTS/METHODS: This was a double-blind, randomized controlled trial. We recruited pregnant women with a body mass index (BMI) >= 30 kg/m2 at their initial prenatal visit ( < 13 weeks gestation) and collected blood and urine samples at baseline, 24-28 weeks, and 32-36 weeks to measure micronutrient concentrations (vitamin C, E, B6 and folate), markers of inflammation (C-reactive protein, interleukin-6, 8, and 1beta) and oxidative stress (8-epi-PGF2alpha and malondialdehyde). We collected maternal and infant health data from enrollment to delivery as secondary outcomes. We enrolled 128 participants (64 in each arm), and 98 (49 in each arm) completed follow-up through delivery.
+
+ INTERVENTION: Both groups received a standard prenatal vitamin containing the recommended daily allowance of micronutrients in pregnancy. In addition, the intervention group received a supplement with 90 mg vitamin C, 30 alphaTU vitamin E, 18 mg vitamin B6, and 800 mug folic acid, and the control group received a placebo.
+
+ RESULTS: The intervention group had higher vit B6 (log transformed (ln), beta 24-28 weeks: 0.76 nmol/L (95% CI: 0.40, 1.12); beta 32-36 weeks: 0.52 nmol/L (95% CI: 0.17, 0.88)) than the control group. Vitamins C, E, erythrocyte RBC folate concentrations did not differ by randomization group. The intervention did not impact biomarkers of inflammation or oxidative stress. There were no differences in maternal or neonatal clinical outcomes by randomization group.
+
+ CONCLUSIONS: Higher concentrations of antioxidant vitamins during pregnancy increased specific micronutrients and did not impact maternal inflammation and oxidative stress, which may be related to dosing or type of supplementation provided.
+
+ CLINICAL TRIAL REGISTRATION: Clinical Trial Identification Number: NCT02802566; URL of the Registration Site: www.
+
+ CLINICALTRIALS: gov . Copyright © 2024. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Micronutrients). 0 (Antioxidants). 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1038%2fs41366-024-01472-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sen&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Supplementation+with+antioxidant+micronutrients+in+pregnant+women+with+obesity%3A+a+randomized+controlled+trial.&volume=48&issue=6&spage=796&epage=807&date=2024&doi=10.1038%2Fs41366-024-01472-z&pmid=38396126&sid=OVID:medline
+
+<38>
+Unique Identifier
+ 38791302
+Title
+ Cartilage Oligomeric Matrix Protein in Osteoarthritis and Obesity-Do New Considerations Emerge?.
+Source
+ International Journal of Molecular Sciences. 25(10), 2024 May 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lambova SN; Batsalova T; Moten D; Dzhambazov B
+Author NameID
+ Batsalova, Tsvetelina; ORCID: https://orcid.org/0000-0002-6560-1945
+ Moten, Dzhemal; ORCID: https://orcid.org/0000-0002-7998-5214
+ Dzhambazov, Balik; ORCID: https://orcid.org/0000-0001-8052-5840
+Authors Full Name
+ Lambova, Sevdalina Nikolova; Batsalova, Tsvetelina; Moten, Dzhemal; Dzhambazov, Balik.
+Institution
+ Lambova, Sevdalina Nikolova. Department of Propaedeutics of Internal Diseases "Prof Dr Anton Mitov", Faculty of Medicine, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria.
+ Lambova, Sevdalina Nikolova. Department of Rheumatology, MHAT "Sveti Mina", 4000 Plovdiv, Bulgaria.
+ Batsalova, Tsvetelina. Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria.
+ Moten, Dzhemal. Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria.
+ Dzhambazov, Balik. Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria.
+MeSH Subject Headings
+ Humans
+ Cartilage Oligomeric Matrix Protein/bl [Blood]
+ Cartilage Oligomeric Matrix Protein/me [Metabolism]
+ *Cartilage Oligomeric Matrix Protein
+ Obesity/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity
+ Female
+ Male
+ Middle Aged
+ Osteoarthritis, Knee/me [Metabolism]
+ *Osteoarthritis, Knee
+ Aged
+ Body Mass Index
+ Biomarkers/bl [Blood]
+ Cartilage, Articular/me [Metabolism]
+ Cartilage, Articular/pa [Pathology]
+ Case-Control Studies
+Keyword Heading
+ BMI
+ COMP
+ biomarker
+ diagnosis
+ obesity
+ osteoarthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The diagnosis of osteoarthritis (OA) is based on radiological changes that are delayed, along with clinical symptoms. Early and very early diagnosis at the stage of molecular pathology may eventually offer an opportunity for early therapeutic intervention that may retard and prevent future damage. Cartilage oligomeric matrix protein (COMP) is a non-collagenous extracellular matrix protein that promotes the secretion and aggregation of collagen and contributes to the stability of the extracellular matrix. There are contradictory literature data and currently, the parameter is used only for scientific purposes and its significance is not well-determined. The serum level of COMP in patients with metabolic type OA of the knee has not been evaluated. The aim of the study was to analyze serum COMP levels in metabolic knee OA and controls with different BMI. Our results showed that the mean COMP values were significantly higher in the control group (1518.69 +/- 232.76 ng/mL) compared to the knee OA patients (1294.58 +/- 360.77 ng/mL) (p = 0.0012). This may be related to the smaller cartilage volume in OA patients. Additionally, COMP levels negatively correlated with disease duration (p = 0.04). The COMP level in knee OA with BMI below 30 kg/m2 (n = 61, 1304.50 +/- 350.60 ng/mL) was higher compared to cases with BMI >= 30 kg/m2 (n = 76, 1286.63 +/- 370.86 ng/mL), but the difference was not significant (p = 0.68). Whether this finding is related to specific features in the evolution of the metabolic type of knee OA remains to be determined. Interestingly, comparison of COMP levels in the controls with different BMI revealed significantly higher values in overweight and obese individuals (1618.36 +/- 203.76 ng/mL in controls with BMI >= 25 kg/m2, n = 18, 1406.61 +/- 216.41 ng/mL, n = 16; p = 0.0092). Whether this finding is associated with increased expression of COMP in the adipose tissue or with more intensive cartilage metabolism in relation to higher biomechanical overload in obese patients, considering the earlier development of metabolic type knee OA as an isolated finding, remains to be determined.
+Registry Number/Name of Substance
+ 0 (Cartilage Oligomeric Matrix Protein). 0 (COMP protein, human). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fijms25105263
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lambova&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Cartilage+Oligomeric+Matrix+Protein+in+Osteoarthritis+and+Obesity-Do+New+Considerations+Emerge%3F.&volume=25&issue=10&spage=5263&epage=&date=2024&doi=10.3390%2Fijms25105263&pmid=38791302&sid=OVID:medline
+
+<39>
+Unique Identifier
+ 38307453
+Title
+ Alterations in nonesterified free fatty acid trafficking rather than hyperandrogenism contribute to metabolic health in obese women with polycystic ovary syndrome.
+Source
+ Fertility & Sterility. 121(6):1040-1052, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ezeh U; Chen YI; Pall M; Buyalos RP; Chan JL; Pisarska MD; Azziz R
+Authors Full Name
+ Ezeh, Uche; Chen, Yd Ida; Pall, Marita; Buyalos, Richard P; Chan, Jessica L; Pisarska, Margareta D; Azziz, Ricardo.
+Institution
+ Ezeh, Uche. California IVF Fertility Center, Sacramento, California; Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California; Department of Obstetrics and Gynecology, Heersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, Alabama; Department of Obstetrics and Gynecology, Alta Bates Summit Medical Center (Sutter), Berkeley, California.
+ Chen, Yd Ida. Department of Pediatrics and Medicine, Harbor- University of California (UCLA) Medical Center, Torrance, California; Department of Medicine, The David Geffen School of Medicine, UCLA, Los Angeles, California.
+ Pall, Marita. Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
+ Buyalos, Richard P. Fertility and Surgical Associates of California, Thousand Oaks, California.
+ Chan, Jessica L. Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
+ Pisarska, Margareta D. Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California; Department of Obstetrics and Gynecology, UCLA, Los Angeles, California.
+ Azziz, Ricardo. Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California; Department of Obstetrics and Gynecology, Heersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, Alabama; Department of Medicine, Heersink School of Medicine, UAB, Birmingham, Alabama; Department of Healthcare Organization and Policy, School of Public Health, UAB, Birmingham, Alabama; Department of Health Policy, Management and Behavior, School of Public Health, State University of New York at Albany, Albany, New York. Electronic address: razziz@uabmc.edu.
+MeSH Subject Headings
+ Humans
+ Female
+ Polycystic Ovary Syndrome/me [Metabolism]
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/co [Complications]
+ *Polycystic Ovary Syndrome
+ Hyperandrogenism/me [Metabolism]
+ Hyperandrogenism/bl [Blood]
+ *Hyperandrogenism
+ Adult
+ Fatty Acids, Nonesterified/bl [Blood]
+ Fatty Acids, Nonesterified/me [Metabolism]
+ *Fatty Acids, Nonesterified
+ Obesity/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity
+ Cross-Sectional Studies
+ Insulin Resistance/ph [Physiology]
+ *Insulin Resistance
+ Prospective Studies
+ Young Adult
+ Glucose Tolerance Test
+ Blood Glucose/me [Metabolism]
+ Insulin/bl [Blood]
+ Biomarkers/bl [Blood]
+Keyword Heading
+ PCOS
+ insulin resistance
+ metabolic dysfunction
+ nonesterified free fatty acids
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To determine whether alterations in nonesterified fatty acid (NEFA) dynamics or degree of hyperandrogenism (HA) contribute to the difference in insulin sensitivity between women with metabolically healthy obese polycystic ovary syndrome (PCOS) (MHO-PCOS) and women with metabolically unhealthy obese PCOS (MUO-PCOS).
+
+ DESIGN: Prospective cross-sectional study.
+
+ SETTING: Tertiary-care academic center.
+
+ PATIENTS: One hundred twenty-five obese women with PCOS.
+
+ INTERVENTION: Consecutive obese (body mass index [BMI] >= 30 kg/m2) oligo-ovulatory women (n = 125) with PCOS underwent an oral glucose tolerance test and a subgroup of 16 participants underwent a modified frequently sampled intravenous glucose tolerance test to determine insulin-glucose and -NEFA dynamics.
+
+ MAIN OUTCOME MEASURES: Degree of insulin resistance (IR) in adipose tissue (AT) basally (Adipo-IR) and dynamically (the nadir in NEFA levels observed [NEFAnadir], the time it took for NEFA levels to reach nadir [TIMEnadir], and the percent suppression in plasma NEFA levels from baseline to nadir [%NEFAsupp]); peak lipolysis rate (SNEFA) and peak rate of NEFA disposal from plasma pool (KNEFA); whole-body insulin-glucose interaction (acute response of insulin to glucose [AIRg], insulin sensitivity index [Si], glucose effectiveness [Sg], and disposition index [Di]); and HA (hirsutism score, total and free testosterone levels, and dehydroepiandrosterone sulfate levels).
+
+ RESULTS: A total of 85 (68%) women were MUO-PCOS and 40 (32%) were MHO-PCOS using the homeostasis model of assessment of IR. Subjects with MUO-PCOS and MHO-PCOS did not differ in mean age, BMI, waist-to-hip ratio, HA, and lipoprotein levels. By a modified frequently sampled intravenous glucose tolerance test, eight women with MUO-PCOS had lesser Si, KNEFA, and the percent suppression in plasma NEFA levels from baseline to nadir (%NEFAsupp) and greater TIMEnadir, NEFAnadir, and baseline adipose tissue IR index (Adipo-IR) than eight subjects with MHO-PCOS, but similar fasting NEFA levels and SNEFA. Women with MUO-PCOS had a higher homeostasis model of assessment-beta% and fasting insulin levels than women with MHO-PCOS. In bivalent analysis, Si correlated strongly and negatively with Adipo-IR and NEFAnadir, weakly and negatively with TIMEnadir, and positively with KNEFA and %NEFAsupp, in women with MUO-PCOS only.
+
+ CONCLUSION: Independent of age and BMI, women with MUO-PCOS have reduced NEFA uptake and altered insulin-mediated NEFA suppression, but no difference in HA, compared with women with MHO-PCOS. Altered insulin-mediated NEFA suppression, rather than HA or lipolysis rate, contributes to variations in insulin sensitivity among obese women with PCOS. Copyright © 2024 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Fatty Acids, Nonesterified). 0 (Blood Glucose). 0 (Insulin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.fertnstert.2024.01.030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ezeh&issn=0015-0282&title=Fertility+%26+Sterility&atitle=Alterations+in+nonesterified+free+fatty+acid+trafficking+rather+than+hyperandrogenism+contribute+to+metabolic+health+in+obese+women+with+polycystic+ovary+syndrome.&volume=121&issue=6&spage=1040&epage=1052&date=2024&doi=10.1016%2Fj.fertnstert.2024.01.030&pmid=38307453&sid=OVID:medline
+
+<40>
+Unique Identifier
+ 38783200
+Title
+ Correlation between triglyceride glucose-body mass index and hypertension risk: evidence from a cross-sectional study with 60,283 adults in eastern China.
+Source
+ BMC Cardiovascular Disorders. 24(1):270, 2024 May 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen Y; Du J; Zhou N; Song Y; Wang W; Hong X
+Authors Full Name
+ Chen, Yijia; Du, Jinling; Zhou, Nan; Song, Yingqian; Wang, Weiwei; Hong, Xin.
+Institution
+ Chen, Yijia. Department of Chronic and Noncommunicable Disease Prevention, Nanjing Medical University Affiliated Nanjing Municipal Center for Disease Control and Prevention, Nanjing, 210003, China.
+ Du, Jinling. Guangzhou Liwan Center for Disease Control and Prevention, Guangzhou, 510176, China.
+ Zhou, Nan. Department of Chronic and Noncommunicable Disease Prevention, Nanjing Medical University Affiliated Nanjing Municipal Center for Disease Control and Prevention, Nanjing, 210003, China.
+ Zhou, Nan. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
+ Song, Yingqian. Nanjing Gulou Center for Disease Control and Prevention, Nanjing, 210015, China.
+ Wang, Weiwei. Department of Chronic and Noncommunicable Disease Prevention, Nanjing Medical University Affiliated Nanjing Municipal Center for Disease Control and Prevention, Nanjing, 210003, China.
+ Hong, Xin. Department of Chronic and Noncommunicable Disease Prevention, Nanjing Medical University Affiliated Nanjing Municipal Center for Disease Control and Prevention, Nanjing, 210003, China. nj_hongxin@126.com.
+ Hong, Xin. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. nj_hongxin@126.com.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ Hypertension/ep [Epidemiology]
+ Hypertension/di [Diagnosis]
+ Hypertension/bl [Blood]
+ *Hypertension
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Middle Aged
+ Risk Factors
+ Adult
+ *Body Mass Index
+ Triglycerides/bl [Blood]
+ *Triglycerides
+ Blood Glucose/me [Metabolism]
+ Blood Glucose/an [Analysis]
+ *Blood Glucose
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Risk Assessment
+ Aged
+ Obesity/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ Obesity/bl [Blood]
+ Insulin Resistance
+ Multivariate Analysis
+ Young Adult
+ Blood Pressure
+ Odds Ratio
+ ROC Curve
+ Predictive Value of Tests
+ Chi-Square Distribution
+ Logistic Models
+ Area Under Curve
+Keyword Heading
+ Body mass index
+ Hypertension
+ Triglyceride
+ Triglyceride glucose-body mass index
+ TyG-BMI
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Insulin resistance (IR) and obesity are established risk factors for hypertension, with triglyceride-glucose (TyG) serving as a recognized surrogate marker for IR. The aim of this study was to investigate the association between TyG-BMI and hypertension in the general population.
+
+ METHODS: A total of 60,283 adults aged >=18 years who underwent face-to-face questionnaires, anthropometric measurements, and laboratory examination were included in this study. Multivariable logistic regression models and receiver operating characteristic curve (ROC) were used to determine the association between TyG-BMI and hypertension. The restricted cubic spline model was used for the dose-response analysis.
+
+ RESULTS: After fully adjusting for confounding variables, multivariate logistic regression model showed a stable positive association between TyG-BMI and hypertension (OR: 1.61 per SD increase; 95% CI: 1.55-1.67; P-trend < 0.001). The multivariate adjusted OR and 95% CI for the highest TyG-BMI quartile compared with the lowest quartile were 2.52 (95% CI 2.28-2.78). Dose-response analysis using restricted cubic spline confirmed that the association between TyG-BMI index and hypertension was linear. Subgroup analyses showed that stronger associations between TyG-BMI index and hypertension were detected in young and middle-aged individuals (P for interaction < 0.05). ROC analysis showed that TyG-BMI index could better predict the risk of hypertension than other parameters (TyG-BMI cut-off value: 207.105, AUC: 0.719, sensitivity 65.5%, specificity 66.8%), particularly among young and middle-aged people.
+
+ CONCLUSION: The TyG-BMI index was independently associated with hypertension in the study population. Further studies are required to confirm this relationship. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12872-024-03934-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Correlation+between+triglyceride+glucose-body+mass+index+and+hypertension+risk%3A+evidence+from+a+cross-sectional+study+with+60%2C283+adults+in+eastern+China.&volume=24&issue=1&spage=270&epage=&date=2024&doi=10.1186%2Fs12872-024-03934-8&pmid=38783200&sid=OVID:medline
+
+<41>
+Unique Identifier
+ 37984403
+Title
+ Association and Pathways between Dietary Manganese Intake and Incident Venous Thromboembolism.
+Source
+ Thrombosis & Haemostasis. 124(6):546-554, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang Y; Zhang Y; Yang S; Xiang H; Zhou C; Ye Z; Liu M; He P; Zhang Y; Gan X; Qin X
+Author NameID
+ Qin, Xianhui; ORCID: https://orcid.org/0000-0001-7812-7982
+Authors Full Name
+ Huang, Yu; Zhang, Yanjun; Yang, Sisi; Xiang, Hao; Zhou, Chun; Ye, Ziliang; Liu, Mengyi; He, Panpan; Zhang, Yuanyuan; Gan, Xiaoqin; Qin, Xianhui.
+Institution
+ Huang, Yu. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Zhang, Yanjun. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Yang, Sisi. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Xiang, Hao. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Zhou, Chun. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Ye, Ziliang. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Liu, Mengyi. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ He, Panpan. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Zhang, Yuanyuan. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Gan, Xiaoqin. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+ Qin, Xianhui. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
+MeSH Subject Headings
+ Humans
+ Male
+ Middle Aged
+ Female
+ Venous Thromboembolism/ep [Epidemiology]
+ Venous Thromboembolism/bl [Blood]
+ *Venous Thromboembolism
+ Manganese/bl [Blood]
+ Manganese/ad [Administration & Dosage]
+ *Manganese
+ Incidence
+ Adult
+ Aged
+ Risk Factors
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ C-Reactive Protein/me [Metabolism]
+ C-Reactive Protein/an [Analysis]
+ *C-Reactive Protein
+ Diet/ae [Adverse Effects]
+ *Diet
+ United Kingdom/ep [Epidemiology]
+ Body Mass Index
+ Obesity/ep [Epidemiology]
+ Obesity/bl [Blood]
+ Pulmonary Embolism/ep [Epidemiology]
+ Pulmonary Embolism/bl [Blood]
+ Waist Circumference
+ Venous Thrombosis/ep [Epidemiology]
+ Venous Thrombosis/bl [Blood]
+ Erythrocyte Indices
+ Prospective Studies
+ Follow-Up Studies
+ Mean Platelet Volume
+Abstract
+ BACKGROUND: The association between dietary manganese (Mn) intake and the risk of venous thromboembolism (VTE) remains unknown. We aimed to investigate the associations of dietary Mn intake with incident VTE, and the underlying mediating roles of obesity markers (body mass index [BMI] and waist circumference), hemorheological parameters (red cell distribution width [RDW], platelet count [PLT], and mean platelet volume [MPV]), and inflammatory biomarkers (C-reactive protein [CRP] and white blood cell count [WBC]) in this association.
+
+ METHODS: A total of 202,507 adults from the UK Biobank with complete dietary data and without VTE at baseline were included. Dietary information was collected by the online 24-hour diet recall questionnaires (Oxford WebQ). The primary outcome was incident VTE, a composite of incident deep vein thrombosis (DVT) and pulmonary embolism (PE).
+
+ RESULTS: During a median follow-up of 11.6 years, 4,750 participants developed incident VTE. Overall, there were significantly inverse relationships of dietary Mn intake with incident VTE (per 1 mg/day increment; adjusted hazard ratio [HR]: 0.92; 95% confidence interval [CI]: 0.90-0.95), incident DVT (per 1 mg/day increment; adjusted HR: 0.93; 95% CI: 0. 90-0.96), and incident PE (per 1 mg/day increment; adjusted HR: 0.91; 95% CI: 0.88-0.95). BMI, waist circumference, RDW, CRP, and WBC significantly mediated the association between dietary Mn intake and incident VTE, with the mediated proportions of 36.0, 36.5, 4.2, 4.3, and 1.6%, respectively. However, MPV and PLT did not significantly mediate the association.
+
+ CONCLUSION: Our study shows that dietary Mn intake was inversely associated with incident VTE. The inverse association was mainly mediated by obesity, followed by inflammatory biomarkers and RDW. Our findings are just hypothesis-generating, and further confirmation of our findings in more studies is essential. Copyright Thieme. All rights reserved.
+Registry Number/Name of Substance
+ 42Z2K6ZL8P (Manganese). 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1055%2fa-2213-8939
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=0340-6245&title=Thrombosis+%26+Haemostasis&atitle=Association+and+Pathways+between+Dietary+Manganese+Intake+and+Incident+Venous+Thromboembolism.&volume=124&issue=6&spage=546&epage=554&date=2024&doi=10.1055%2Fa-2213-8939&pmid=37984403&sid=OVID:medline
+
+<42>
+Unique Identifier
+ 37764780
+Title
+ Effect of a Telephone-Based Lifestyle Intervention on Weight, Body Composition, and Metabolic Biomarkers in Rural Ohio: Results from a Randomized Pilot Study.
+Source
+ Nutrients. 15(18), 2023 Sep 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang X; DeScenza VR; Chaplow ZL; Kilar M; Bowman J; Buga A; Kackley ML; Shoben AB; Felix AS; Paskett ED; Focht BC
+Author NameID
+ DeScenza, Victoria R; ORCID: https://orcid.org/0000-0002-7649-4137
+ Chaplow, Zachary L; ORCID: https://orcid.org/0000-0003-2758-0829
+ Buga, Alex; ORCID: https://orcid.org/0000-0001-8509-4330
+ Kackley, Madison L; ORCID: https://orcid.org/0000-0001-5527-9529
+Authors Full Name
+ Zhang, Xiaochen; DeScenza, Victoria R; Chaplow, Zachary L; Kilar, Megan; Bowman, Jessica; Buga, Alex; Kackley, Madison L; Shoben, Abigail B; Felix, Ashley S; Paskett, Electra D; Focht, Brian C.
+Institution
+ Zhang, Xiaochen. Division of Cancer Prevention and Control, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.
+ Zhang, Xiaochen. Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH 43210, USA.
+ Zhang, Xiaochen. Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
+ DeScenza, Victoria R. Kinesiology, College of Agriculture, Health, and Natural Resource, University of Connecticut, Storrs, CT 06268, USA.
+ Chaplow, Zachary L. Kinesiology, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
+ Kilar, Megan. Kinesiology, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
+ Bowman, Jessica. Kinesiology, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
+ Buga, Alex. Kinesiology, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
+ Kackley, Madison L. Kinesiology, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
+ Shoben, Abigail B. Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH 43210, USA.
+ Felix, Ashley S. Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH 43210, USA.
+ Paskett, Electra D. Division of Cancer Prevention and Control, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.
+ Focht, Brian C. Kinesiology, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
+MeSH Subject Headings
+ Adult
+ Humans
+ Female
+ Middle Aged
+ Male
+ Pilot Projects
+ *Rural Population
+ Ohio
+ Obesity/th [Therapy]
+ Obesity/px [Psychology]
+ *Obesity
+ Life Style
+ Biomarkers
+ Lipids
+ Body Composition
+ Telephone
+Keyword Heading
+ health disparities
+ metabolic biomarkers
+ obesity
+ remote
+ rural
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Rural residents experience higher rates of obesity, obesity-related chronic diseases, and poorer lifestyle. Promoting physical activity and healthy eating are critical for rural residents; however, lack of resources and access barriers limit the feasibility of in-person lifestyle interventions. There is a need to design and deliver remotely accessible lifestyle interventions in this population. This pilot study examined the effect of a telephone-based lifestyle intervention on weight, body composition, lipids, and inflammatory biomarkers among rural Ohio residents. Rural Ohio adults with overweight/obesity (n = 40) were 2:1 randomized to a 15-week telephone-based lifestyle intervention (n = 27) or control group (n = 13). The lifestyle intervention group received weekly telephone counseling sessions emphasizing healthy eating and increasing physical activity. The control group received educational brochures describing physical activity and dietary recommendations. Weight, body composition, fasting blood lipids, and inflammatory biomarkers were objectively measured at baseline and 15 weeks at local community centers (trial registration#: NCT05040152 at ClinicalTrial.gov). Linear mixed models were used to examine change over time by group. Participants were mostly female, with an average age of 49 years. Over the 15-week trial, the lifestyle intervention showed superior improvements in total cholesterol ( = -18.7 +/- 7.8 mg/dL, p = 0.02) and LDL ( = -17.1 +/- 8.1 mg/dL, p = 0.04) vs. control, whereas no significant between-group differences in weight, body composition, or inflammation were observed. Our findings suggest that a 15-week telephone-based lifestyle intervention may offer metabolic benefits that reduce disease risk in rural adults with obesity. Future large-scale studies are needed to determine the efficacy of remotely accessible lifestyle interventions in rural populations, with the goal of reducing obesity-related disparities.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu15183998
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=2072-6643&title=Nutrients&atitle=Effect+of+a+Telephone-Based+Lifestyle+Intervention+on+Weight%2C+Body+Composition%2C+and+Metabolic+Biomarkers+in+Rural+Ohio%3A+Results+from+a+Randomized+Pilot+Study.&volume=15&issue=18&spage=&epage=&date=2023&doi=10.3390%2Fnu15183998&pmid=37764780&sid=OVID:medline
+
+<43>
+Unique Identifier
+ 38445643
+Title
+ Obesity modifies the association between diabetes and iron biomarkers and red cell indices in reproductive-aged women in the United States.
+Source
+ Journal of Investigative Medicine. 72(5):425-437, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aguree S; Owora A; Hawkins M; Gletsu-Miller N
+Authors Full Name
+ Aguree, Sixtus; Owora, Arthur; Hawkins, Misty; Gletsu-Miller, Nana.
+Institution
+ Aguree, Sixtus. Department of Applied Health Science, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA.
+ Owora, Arthur. Department of Pediatrics, School of Medicine, Indiana University, Indianapolis, IN, USA.
+ Owora, Arthur. Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.
+ Hawkins, Misty. Department of Health and Wellness Design, School of Public Health, Indiana University, Bloomington, IN, USA.
+ Gletsu-Miller, Nana. Department of Applied Health Science, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA.
+MeSH Subject Headings
+ Humans
+ Female
+ Adult
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Middle Aged
+ United States/ep [Epidemiology]
+ Iron/bl [Blood]
+ *Iron
+ *Erythrocyte Indices
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus
+ Young Adult
+ Body Mass Index
+Keyword Heading
+ HbA1c
+ Iron deficiency
+ anemia
+ ferritin
+ glycemic control
+ transferrin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and diabetes are associated with impaired iron metabolism. We aimed to examine the independent relationship between diabetes and iron after controlling for body weight (or obesity) in women aged 20-49 years. The National Health and Nutrition Examination Survey data from 2015 to 2018 were used in this investigation. Body composition data, HbAc1, iron biomarkers (serum ferritin (SF), soluble transferrin receptor (sTfR), and body iron index (BII)), mean corpuscular volume (MCV), mean hemoglobin concentration (MCH), red cell distribution width (RDW), and hemoglobin were used. Linear regression models were used to examine how and to what extent body mass index (BMI) modified the relationship between diabetes and iron status biomarkers. A total of 1834 women aged 20-49 were included in the analysis with a mean (SD) age of 32 .2 +/- 6.1 years and BMI of 29.5 +/- 6.9 kg/m2. The mean SF (p = 0.014) and BII (p < 0.001) were lower, while sTfR (p < 0.001) was higher in women with diabetes than those with no diabetes. Mean estimates for MCV and MCH were lower, while RDW (p = 0.001) was higher in diabetes patients (all p < 0.001). Women with diabetes were more likely to have iron deficiency, anemia, and iron deficiency anemia than those without diabetes (18.1% vs 8.6%, p < 0.001), (24.4% vs 8.4%, p < 0.001), and (14.8% vs 5.2%, p < 0.001), respectively. Among women with obesity, those with diabetes had lower predicted ferritin (beta = -0.19, p = 0.016), BII (beta = -0.99, p = 0.016), and hemoglobin (beta = -0.27, p = 0.042) than those without diabetes. The study shows that diabetes is linked to lower iron stores; this is exacerbated in those with obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). E1UOL152H7 (Iron).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1177%2f10815589241240059
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aguree&issn=1081-5589&title=Journal+of+Investigative+Medicine&atitle=Obesity+modifies+the+association+between+diabetes+and+iron+biomarkers+and+red+cell+indices+in+reproductive-aged+women+in+the+United+States.&volume=72&issue=5&spage=425&epage=437&date=2024&doi=10.1177%2F10815589241240059&pmid=38445643&sid=OVID:medline
+
+<44>
+Unique Identifier
+ 38777475
+Title
+ Are resting metabolic rate and clinical symptoms affected by variation of serum thyroid stimulating hormone levels within the normal range in healthy and women with hypothyroidism? A case-control study.
+Source
+ Clinical Nutrition ESPEN. 61:71-78, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Harsini AR; Mohajeri-Tehrani MR; Sajjadi-Jazi SM; Naeini F; Valisoltani N; Sadeghi E; Mohammadi H; Hosseini S
+Authors Full Name
+ Harsini, Asma Rajabi; Mohajeri-Tehrani, Mohammad Reza; Sajjadi-Jazi, Sayed Mahmoud; Naeini, Fatemeh; Valisoltani, Neda; Sadeghi, Erfan; Mohammadi, Hamed; Hosseini, Saeed.
+Institution
+ Harsini, Asma Rajabi. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Mohajeri-Tehrani, Mohammad Reza. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Sajjadi-Jazi, Sayed Mahmoud. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Naeini, Fatemeh. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Valisoltani, Neda. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Sadeghi, Erfan. Research Consultation Center (RCC), Shiraz University of Medical Sciences, Shiraz, Iran.
+ Mohammadi, Hamed. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Hosseini, Saeed. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: hosseinis@tums.ac.ir.
+MeSH Subject Headings
+ Humans
+ Female
+ Hypothyroidism/bl [Blood]
+ *Hypothyroidism
+ Case-Control Studies
+ Thyrotropin/bl [Blood]
+ *Thyrotropin
+ Adult
+ *Basal Metabolism
+ Middle Aged
+ Energy Metabolism
+ Body Composition
+ Thyroxine/bl [Blood]
+ Obesity/bl [Blood]
+ Reference Values
+ Biomarkers/bl [Blood]
+ Exercise/ph [Physiology]
+Keyword Heading
+ Clinical symptoms
+ Hypothyroidism women
+ Resting metabolic rate
+ TSH levels
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: It is unclear whether variation in thyroid stimulating hormone (TSH) levels within the reference range affect energy expenditure and clinical symptoms and even within the normal range of TSH levels, resting energy expenditure may alter. The aim of the present study was to determine whether treated hypothyroid subjects and healthy subjects with a low-normal TSH range (0.3-2.3 mIU/L) have better clinical outcomes and increased energy expenditure than those with a high-normal TSH range (2.3-4.3 mIU/L).
+
+ METHODS: This was a case-control study of 160 overweight/obese women with TSH levels across the reference range of 0.3-4.3 mU/l. Subjects were paired in four groups: healthy subjects with low-normal target TSH (n = 40), healthy subjects with high-normal target TSH (n = 40), subjects with treated hypothyroidism with low-normal target TSH (n = 40), and subjects with treated hypothyroidism with high-normal target TSH (n = 40). Resting energy expenditure (RMR), dietary intake, body composition, physical activity, and biochemical markers were assessed.
+
+ RESULTS: Subjects with low-normal (<=2.3 mU/L) and high-normal (>2.3 mU/L) TSH levels did not differ in terms of RMR, serum T3 levels, and clinical symptoms except fatigue (P = 0.013). However, serum fT4 levels were found to be significantly different between the study groups (P = 0.002). Serum fT4 concentration was the highest in subjects with treated hypothyroidism with low-normal target TSH.
+
+ CONCLUSION: Variation in serum TSH levels within the reference range did not significantly affect REE and clinical symptoms except fatigue in healthy and women with hypothyroidism. Copyright © 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 9002-71-5 (Thyrotropin). Q51BO43MG4 (Thyroxine). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.clnesp.2024.02.030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Harsini&issn=2405-4577&title=Clinical+Nutrition+ESPEN&atitle=Are+resting+metabolic+rate+and+clinical+symptoms+affected+by+variation+of+serum+thyroid+stimulating+hormone+levels+within+the+normal+range+in+healthy+and+women+with+hypothyroidism%3F+A+case-control+study.&volume=61&issue=&spage=71&epage=78&date=2024&doi=10.1016%2Fj.clnesp.2024.02.030&pmid=38777475&sid=OVID:medline
+
+<45>
+Unique Identifier
+ 38731908
+Title
+ Synergistic Effects of Weight Loss and Catheter Ablation: Can microRNAs Serve as Predictive Biomarkers for the Prevention of Atrial Fibrillation Recurrence?. [Review]
+Source
+ International Journal of Molecular Sciences. 25(9), 2024 Apr 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Forster CY; Kunzel SR; Shityakov S; Stavrakis S
+Author NameID
+ Forster, Carola Y; ORCID: https://orcid.org/0000-0002-3878-247X
+ Kunzel, Stephan R; ORCID: https://orcid.org/0000-0001-6302-1755
+ Shityakov, Sergey; ORCID: https://orcid.org/0000-0002-6953-9771
+Authors Full Name
+ Forster, Carola Y; Kunzel, Stephan R; Shityakov, Sergey; Stavrakis, Stavros.
+Institution
+ Forster, Carola Y. Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University of Wurzburg, 97080 Wurzburg, Germany.
+ Kunzel, Stephan R. Institute for Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Technische Universitat Dresden, 01307 Dresden, Germany.
+ Kunzel, Stephan R. Institute for Transfusion Medicine, German Red Cross Blood Donation Service North-East, 01307 Dresden, Germany.
+ Shityakov, Sergey. Laboratory of Chemoinformatics, Infochemistry Scientific Center, ITMO University, 197101 Saint-Petersburg, Russia.
+ Stavrakis, Stavros. Cardiovascular Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+MeSH Subject Headings
+ Atrial Fibrillation/me [Metabolism]
+ Atrial Fibrillation/ge [Genetics]
+ Atrial Fibrillation/et [Etiology]
+ *Atrial Fibrillation
+ Humans
+ *Weight Loss
+ MicroRNAs/ge [Genetics]
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ *Biomarkers
+ Catheter Ablation/mt [Methods]
+ *Catheter Ablation
+ Recurrence
+ Atrial Remodeling
+ Animals
+ Obesity/me [Metabolism]
+ Obesity/co [Complications]
+Keyword Heading
+ ROS
+ atrial fibrillation
+ catheter ablation
+ cytokine
+ fibrosis
+ hypertension
+ inflammaging
+ microRNA
+ obesity
+ recurrent atrial fibrillation
+ sex differences
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In atrial fibrillation (AF), multifactorial pathologic atrial alterations are manifested by structural and electrophysiological changes known as atrial remodeling. AF frequently develops in the context of underlying cardiac abnormalities. A critical mechanistic role played by atrial stretch is played by abnormal substrates in a number of conditions that predispose to AF, including obesity, heart failure, hypertension, and sleep apnea. The significant role of overweight and obesity in the development of AF is known; however, the differential effect of overweight, obesity, cardiovascular comorbidities, lifestyle, and other modifiable risk factors on the occurrence and recurrence of AF remains to be determined. Reverse remodeling of the atrial substrate and subsequent reduction in the AF burden by conversion into a typical sinus rhythm has been associated with weight loss through lifestyle changes or surgery. This makes it an essential pillar in the management of AF in obese patients. According to recently published research, microRNAs (miRs) may function as post-transcriptional regulators of genes involved in atrial remodeling, potentially contributing to the pathophysiology of AF. The focus of this review is on their modulation by both weight loss and catheter ablation interventions to counteract atrial remodeling in AF. Our analysis outlines the experimental and clinical evidence supporting the synergistic effects of weight loss and catheter ablation (CA) in reversing atrial electrical and structural remodeling in AF onset and in recurrent post-ablation AF by attenuating pro-thrombotic, pro-inflammatory, pro-fibrotic, arrhythmogenic, and male-sex-associated hypertrophic remodeling pathways. Furthermore, we discuss the promising role of miRs with prognostic potential as predictive biomarkers in guiding approaches to AF recurrence prevention.
+Registry Number/Name of Substance
+ 0 (MicroRNAs). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fijms25094689
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Forster&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Synergistic+Effects+of+Weight+Loss+and+Catheter+Ablation%3A+Can+microRNAs+Serve+as+Predictive+Biomarkers+for+the+Prevention+of+Atrial+Fibrillation+Recurrence%3F.&volume=25&issue=9&spage=4689&epage=&date=2024&doi=10.3390%2Fijms25094689&pmid=38731908&sid=OVID:medline
+
+<46>
+Unique Identifier
+ 38393627
+Title
+ Obesity contributes to telomere shortening in polycystic ovary syndrome.
+Source
+ Reproductive Sciences. 31(6):1601-1609, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kogure GS; Verruma CG; Santana BA; Calado RT; Ferriani RA; Furtado CLM; Dos Reis RM
+Author NameID
+ Kogure, Gislaine Satyko; ORCID: http://orcid.org/0000-0002-2860-846X
+ Verruma, Carolina Gennari; ORCID: http://orcid.org/0000-0002-2373-1936
+ Calado, Rodrigo T; ORCID: http://orcid.org/0000-0002-7966-6029
+ Ferriani, Rui Alberto; ORCID: http://orcid.org/0000-0001-9308-8344
+ Furtado, Cristiana Libardi Miranda; ORCID: http://orcid.org/0000-0002-8711-8225
+ Dos Reis, Rosana Maria; ORCID: http://orcid.org/0000-0001-9631-4167
+Authors Full Name
+ Kogure, Gislaine Satyko; Verruma, Carolina Gennari; Santana, Barbara A; Calado, Rodrigo T; Ferriani, Rui Alberto; Furtado, Cristiana Libardi Miranda; Dos Reis, Rosana Maria.
+Institution
+ Kogure, Gislaine Satyko. Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, Brazil.
+ Verruma, Carolina Gennari. Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, Brazil.
+ Santana, Barbara A. Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, 14049-900, Brazil.
+ Calado, Rodrigo T. Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, 14049-900, Brazil.
+ Ferriani, Rui Alberto. Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, Brazil.
+ Furtado, Cristiana Libardi Miranda. Experimental Biology Center, Universidade de Fortaleza (UNFOR), Fortaleza, Brazil. clibardim@unifor.br.
+ Furtado, Cristiana Libardi Miranda. Graduate Program in Medical Sciences, Universidade de Fortaleza, Fortaleza, Brazil. clibardim@unifor.br.
+ Furtado, Cristiana Libardi Miranda. Postgraduate Program in Translational Medicine, Drug Research and Development Center, Federal University of Ceara, Fortaleza, Brazil. clibardim@unifor.br.
+ Dos Reis, Rosana Maria. Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, Brazil. romareis@fmrp.usp.br.
+MeSH Subject Headings
+ Humans
+ Polycystic Ovary Syndrome/ge [Genetics]
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/me [Metabolism]
+ *Polycystic Ovary Syndrome
+ Female
+ Obesity/ge [Genetics]
+ Obesity/bl [Blood]
+ *Obesity
+ Adult
+ *Telomere Shortening
+ *Body Mass Index
+ Young Adult
+ Insulin Resistance
+ Telomere/me [Metabolism]
+ Leukocytes/me [Metabolism]
+ Biomarkers/bl [Blood]
+Keyword Heading
+ Body mass index
+ Leukocyte telomere length
+ Metabolic alterations
+ Polycystic ovary syndrome
+ Reproductive outcomes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Polycystic ovary syndrome (PCOS) is a multifactorial disorder and obesity occurs in 38% to 88% of these women. Although hyperandrogenism may contribute to telomere lengthening, increased body mass index (BMI) is associated with telomere erosion. We sought to compare leukocyte telomere length (LTL) in PCOS women with normal, overweight, and obese BMI. We evaluated the relationship between LTL and clinical variables of PCOS and inflammatory biomarkers independent of BMI. A total of 348 women (243 PCOS and 105 non-PCOS) were evaluated for anthropometric measures, total testosterone, androstenedione, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex hormone-binding globulin (SHBG), free androgen index (FAI), fasting insulin and glycemia, lipid profile, homocysteine, C-reactive protein (CRP) and homeostatic model of insulin resistance (HOMA-IR). LTL was measured by qPCR. The PCOS group presented higher weight, waist circumference, BMI, testosterone, LH, fasting insulin, FAI, and HOMA-IR, and lower E2, SHBG, and fasting glycemia measures compared with the non-PCOS. When stratified by BMI, LTL was increased in all subgroups in PCOS compared to non-PCOS. However, in the PCOS group, LTL was lower in overweight (P = 0.0187) and obese (P = 0.0018) compared to normal-weight women. The generalized linear model showed that BMI, androstenedione, homocysteine, and CRP were associated with telomere biology. Women with PCOS had longer LTL, however, overweight or obesity progressively contributes to telomere shortening and may affect reproductive outcomes of PCOS, while androstenedione may increase LTL. Copyright © 2024. The Author(s), under exclusive licence to Society for Reproductive Investigation.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs43032-024-01485-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kogure&issn=1933-7191&title=Reproductive+Sciences&atitle=Obesity+contributes+to+telomere+shortening+in+polycystic+ovary+syndrome.&volume=31&issue=6&spage=1601&epage=1609&date=2024&doi=10.1007%2Fs43032-024-01485-z&pmid=38393627&sid=OVID:medline
+
+<47>
+Unique Identifier
+ 38762719
+Title
+ Circulating total and H-specific GDF15 levels are elevated in subjects with MASLD but not in hyperlipidemic but otherwise metabolically healthy subjects with obesity.
+Source
+ Cardiovascular Diabetology. 23(1):174, 2024 May 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Boutari C; Stefanakis K; Simati S; Guatibonza-Garcia V; Valenzuela-Vallejo L; Anastasiou IA; Connelly MA; Kokkinos A; Mantzoros CS
+Authors Full Name
+ Boutari, Chrysoula; Stefanakis, Konstantinos; Simati, Stamatia; Guatibonza-Garcia, Valentina; Valenzuela-Vallejo, Laura; Anastasiou, Ioanna A; Connelly, Margery A; Kokkinos, Alexander; Mantzoros, Christos S.
+Institution
+ Boutari, Chrysoula. Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA.
+ Stefanakis, Konstantinos. Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA.
+ Simati, Stamatia. First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
+ Guatibonza-Garcia, Valentina. Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA.
+ Valenzuela-Vallejo, Laura. Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA.
+ Anastasiou, Ioanna A. First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
+ Connelly, Margery A. Labcorp, Morrisville, NC, 27560, USA.
+ Kokkinos, Alexander. First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
+ Mantzoros, Christos S. Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA. cmantzor@bidmc.harvard.edu.
+ Mantzoros, Christos S. Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, 02218, USA. cmantzor@bidmc.harvard.edu.
+ Mantzoros, Christos S. Department of Medicine, Boston VA Healthcare System, Boston, MA, 02130, USA. cmantzor@bidmc.harvard.edu.
+MeSH Subject Headings
+ Adult
+ Female
+ Humans
+ Male
+ Middle Aged
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Blood Glucose/me [Metabolism]
+ C-Peptide/bl [Blood]
+ *C-Peptide
+ Case-Control Studies
+ Fatty Liver/bl [Blood]
+ Fatty Liver/di [Diagnosis]
+ Gastric Inhibitory Polypeptide/bl [Blood]
+ *Gastric Inhibitory Polypeptide
+ Glucose Tolerance Test
+ Growth Differentiation Factor 15/bl [Blood]
+ *Growth Differentiation Factor 15
+ Hyperlipidemias/bl [Blood]
+ Hyperlipidemias/di [Diagnosis]
+ *Hyperlipidemias
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity
+ *Postprandial Period
+ Time Factors
+ Up-Regulation
+Keyword Heading
+ C-peptide
+ GIP
+ Growth differentiation factor 15
+ Mixed meal test
+ Non-alcoholic fatty liver disease
+ Obesity
+ Oral glucose tolerance test
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Growth differentiation factor 15 (GDF15) is a mitokine, the role of which, total or H-specific, in modulating energy metabolism and homeostasis in obesity-related diseases, such as metabolic dysfunction associated steatotic liver disease (MASLD), has not been fully elucidated in adult humans. We aimed to investigate the fasting and stimulated levels of GDF15, total and H-specific, glucose-dependent insulinotropic polypeptide (GIP) and C-peptide, in two physiology interventional studies: one focusing on obesity, and the other on MASLD.
+
+ METHODS: Study 1 investigated individuals with normal weight or with obesity, undergoing a 3-h mixed meal test (MMT); and study 2, examined adults with MASLD and controls undergoing a 120-min oral glucose tolerance test (OGTT). Exploratory correlations of total and H-specific GDF15 with clinical, hormonal and metabolomic/lipidomic parameters were also performed.
+
+ RESULTS: In study 1, 15 individuals were included per weight group. Fasting and postprandial total and H-specific GDF15 were similar between groups, whereas GIP was markedly higher in leaner individuals and was upregulated following a MMT. Baseline and postprandial C-peptide were markedly elevated in people with obesity compared with lean subjects. GIP was higher in leaner individuals and was upregulated after a MMT, while C-peptide and its overall AUC after a MMT was markedly elevated in people with obesity compared with lean subjects. In study 2, 27 individuals were evaluated. Fasting total GDF15 was similar, but postprandial total GDF15 levels were significantly higher in MASLD patients compared to controls. GIP and C-peptide remained unaffected. The postprandial course of GDF15 was clustered among those of triglycerides and molecules of the alanine cycle, was robustly elevated under MASLD, and constituted the most notable differentiating molecule between healthy and MASLD status. We also present robust positive correlations of the incremental area under the curve of total and H-specific GDF15 with a plethora of lipid subspecies, which remained significant after adjusting for confounders.
+
+ CONCLUSION: Serum GDF15 levels do not differ in relation to weight status in hyperlipidemic but otherwise metabolically healthy individuals. In contrast, GDF15 levels are significantly increased in MASLD patients at baseline and they remain significantly higher compared to healthy participants during OGTT, pointing to a role for GDF15 as a mitokine with important roles in the pathophysiology and possibly therapeutics of MASLD. Trial registration ClinicalTrials.gov NCT03986684, NCT04430946. Copyright © 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
+Registry Number/Name of Substance
+ 0 (GDF15 protein, human).
+Publication Type
+ Clinical Study. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12933-024-02264-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Boutari&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Circulating+total+and+H-specific+GDF15+levels+are+elevated+in+subjects+with+MASLD+but+not+in+hyperlipidemic+but+otherwise+metabolically+healthy+subjects+with+obesity.&volume=23&issue=1&spage=174&epage=&date=2024&doi=10.1186%2Fs12933-024-02264-5&pmid=38762719&sid=OVID:medline
+
+<48>
+Unique Identifier
+ 38690968
+Title
+ Protective effect of provitamin A dietary carotenoid intake on overweight/obesity and their relation to inflammatory and oxidative stress biomarkers - a case-control study.
+Source
+ Food & Function. 15(10):5510-5526, 2024 May 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Koos N; Vahid F; Bohn T
+Author NameID
+ Vahid, Farhad; ORCID: http://orcid.org/0000-0002-7380-3790
+ Bohn, Torsten; ORCID: http://orcid.org/0000-0002-7825-0697
+Authors Full Name
+ Koos, Natalia; Vahid, Farhad; Bohn, Torsten.
+Institution
+ Koos, Natalia. Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. Torsten.Bohn@lih.lu.
+ Vahid, Farhad. Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. Torsten.Bohn@lih.lu.
+ Bohn, Torsten. Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. Torsten.Bohn@lih.lu.
+MeSH Subject Headings
+ Humans
+ Carotenoids/ad [Administration & Dosage]
+ *Carotenoids
+ Female
+ Oxidative Stress/de [Drug Effects]
+ *Oxidative Stress
+ Male
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Middle Aged
+ Case-Control Studies
+ *Obesity
+ *Overweight
+ Adult
+ Inflammation/bl [Blood]
+ *Inflammation
+ Vitamin A/ad [Administration & Dosage]
+ Vitamin A/bl [Blood]
+ Provitamins/ad [Administration & Dosage]
+ beta Carotene/ad [Administration & Dosage]
+ Vegetables/ch [Chemistry]
+ Diet
+ Fruit
+ Xanthophylls/ad [Administration & Dosage]
+ Xanthophylls/pd [Pharmacology]
+ Beta-Cryptoxanthin/ad [Administration & Dosage]
+ Interleukin-6/bl [Blood]
+ Tumor Necrosis Factor-alpha/bl [Blood]
+ Interleukin-1beta/bl [Blood]
+Abstract
+ This investigation assessed associations between dietary carotenoid intake and the odds of overweight/obesity, as well as inflammatory/oxidative stress biomarkers, in 851 participants with overweight/obesity (BMI >=25 kg m-2) and 754 normal-weight controls. A 124-item food-frequency-questionnaire (FFQ) and food composition databases were employed to estimate carotenoid intake. Binary logistic regressions assessed the association of carotenoid intake with the odds of overweight/obesity, adjusting for several potential confounders. Multiple linear regression models revealed associations between carotenoid intake and biomarkers (anthropometrics, blood lipids, inflammation, antioxidant status). Logistic regression models adjusted for various confounders and fruits and vegetables showed protective associations for provitamin A carotenoids (i.e., beta-carotene + alpha-carotene + beta-cryptoxanthin; odds ratio (OR): 0.655, p = 0.041) and astaxanthin (OR: 0.859, p = 0.017). Similarly adjusted multiple linear regressions revealed significant associations between several carotenoids and lower levels of interleukin (IL)-6, IL-1beta, and TNF-alpha and increased IL-10 and total antioxidant capacity. Further analysis revealed that lycopene was significantly associated with increased odds of overweight/obesity (OR: 1.595, p = 0.032) in a model adjusted for various confounders and vegetables (i.e., unadjusted for fruits). A protective association between the sum of provitamin A carotenoid and astaxanthin dietary intake and the odds of having overweight/obesity was found. The findings that carotenoids other than lycopene were not or inversely associated with the odds of overweight/obesity may point toward differentiating effects of various carotenoids or their associations with different food groups. Provitamin A rich food items including fruits and vegetables appear to be a prudent strategy to reduce inflammation and the odds of having overweight/obesity.
+Registry Number/Name of Substance
+ 0 (alpha-carotene).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1039%2fd3fo05648a
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Koos&issn=2042-6496&title=Food+%26+Function&atitle=Protective+effect+of+provitamin+A+dietary+carotenoid+intake+on+overweight%2Fobesity+and+their+relation+to+inflammatory+and+oxidative+stress+biomarkers+-+a+case-control+study.&volume=15&issue=10&spage=5510&epage=5526&date=2024&doi=10.1039%2Fd3fo05648a&pmid=38690968&sid=OVID:medline
+
+<49>
+Unique Identifier
+ 38750109
+Title
+ A study of the relationship between serum asprosin levels and MAFLD in a population undergoing physical examination.
+Source
+ Scientific Reports. 14(1):11170, 2024 05 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lv D; Wang Z; Meng C; Li Y; Ji S
+Authors Full Name
+ Lv, Dan; Wang, Zepu; Meng, Cuiqiao; Li, Yan; Ji, Shuai.
+Institution
+ Lv, Dan. Physical Examination Center, Hebei General Hospital, Shijiazhuang City, Hebei Province, China. ld2449@163.com.
+ Wang, Zepu. Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang City, Hebei Province, China.
+ Meng, Cuiqiao. Physical Examination Center, Hebei General Hospital, Shijiazhuang City, Hebei Province, China.
+ Li, Yan. Physical Examination Center, Hebei General Hospital, Shijiazhuang City, Hebei Province, China.
+ Ji, Shuai. Physical Examination Center, Hebei General Hospital, Shijiazhuang City, Hebei Province, China.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ Fibrillin-1/bl [Blood]
+ *Fibrillin-1
+ Middle Aged
+ Adult
+ *Body Mass Index
+ Obesity/bl [Blood]
+ Physical Examination
+ Elasticity Imaging Techniques
+ Triglycerides/bl [Blood]
+ Overweight/bl [Blood]
+ Waist Circumference
+ Biomarkers/bl [Blood]
+ Aged
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Cholesterol, LDL/bl [Blood]
+Keyword Heading
+ Asprosin
+ Controlled attenuation parameter
+ Metabolic
+ Metabolic-associated fatty liver disease
+ Transient elastography
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Asprosin, an adipokine, was recently discovered in 2016. Here, the correlation between asprosin and metabolic-associated fatty liver disease (MAFLD) was examined by quantitatively assessing hepatic steatosis using transient elastography and controlled attenuation parameter (CAP). According to body mass index (BMI), 1276 adult participants were enrolled and categorized into three groups: normal, overweight, and obese. The study collected and evaluated serum asprosin levels, general biochemical indices, liver stiffness measure, and CAP via statistical analysis. In both overweight and obese groups, serum asprosin and CAP were greater than in the normal group (p < 0.01). Each group showed a positive correlation of CAP with asprosin (p < 0.01). The normal group demonstrated a significant and independent positive relationship of CAP with BMI, low-density lipoprotein cholesterol (LDL-C), asprosin, waist circumference (WC), and triglycerides (TG; p < 0.05). CAP showed an independent positive association (p < 0.05) with BMI, WC, asprosin, fasting blood glucose (FBG), and TG in the overweight group, and with high-density lipoprotein cholesterol (HDL-C) showed an independent negative link (p < 0.01). CAP showed an independent positive relationship (p < 0.05) with BMI, WC, asprosin, TG, LDL-C, FBG, glycated hemoglobin A1c (HbA1c), and alanine transferase in the obese group. CAP also showed an independent positive link (p < 0.01) with BMI, WC, asprosin, TG, LDL-C, and FBG in all participants while independently and negatively correlated (p < 0.01) with HDL-C. Since asprosin and MAFLD are closely related and asprosin is an independent CAP effector, it may offer a novel treatment option for metabolic diseases and MAFLD. Copyright © 2024. The Author(s).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1038%2fs41598-024-62124-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lv&issn=2045-2322&title=Scientific+Reports&atitle=A+study+of+the+relationship+between+serum+asprosin+levels+and+MAFLD+in+a+population+undergoing+physical+examination.&volume=14&issue=1&spage=11170&epage=&date=2024&doi=10.1038%2Fs41598-024-62124-w&pmid=38750109&sid=OVID:medline
+
+<50>
+Unique Identifier
+ 38663803
+Title
+ Growth differentiation factor-15 and metabolic features in chronic heart failure: Insights from the SUPPORT Trial -GDF15 across the BMI spectrum.
+Source
+ International Journal of Cardiology. 407:132093, 2024 Jul 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Teramoto K; Nochioka K; Sakata Y; Kato ET; Nishimura K; Shimokawa H; Yasuda S
+Corporate Author
+ SUPPORT Trial Investigators
+Authors Full Name
+ Teramoto, Kanako; Nochioka, Kotaro; Sakata, Yasuhiko; Kato, Eri Toda; Nishimura, Kunihiro; Shimokawa, Hiroaki; Yasuda, Satoshi.
+Institution
+ Teramoto, Kanako. Department of Biostatistics, National Cerebral and Cardiovascular Center, Osaka, Japan.
+ Nochioka, Kotaro. Division of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: nochioka@cardio.med.tohoku.ac.jp.
+ Sakata, Yasuhiko. Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Osaka, Japan.
+ Kato, Eri Toda. Department of Cardiovascular Medicine and Department of Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan.
+ Nishimura, Kunihiro. Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
+ Shimokawa, Hiroaki. Division of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; International University of Health and Welfare Graduate School, Narita, Japan.
+ Yasuda, Satoshi. Division of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
+MeSH Subject Headings
+ Humans
+ Growth Differentiation Factor 15/bl [Blood]
+ *Growth Differentiation Factor 15
+ Heart Failure/bl [Blood]
+ Heart Failure/ep [Epidemiology]
+ *Heart Failure
+ Female
+ Male
+ Aged
+ Middle Aged
+ *Body Mass Index
+ Chronic Disease
+ Biomarkers/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Follow-Up Studies
+ Thinness/bl [Blood]
+ Thinness/ep [Epidemiology]
+Keyword Heading
+ Cachexia
+ Chronic heart failure
+ Growth differentiation factor-15
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: GDF15 plays pivotal metabolic roles in nutritional stress and serves as a physiological regulator of energy balance. However, the patterns of GDF15 levels in underweight or obese patients with chronic heart failure (CHF) are not well-understood.
+
+ METHODS: We assessed serum GDF15 levels at baseline and 3 years and the temporal changes in 940 Japanese patients (642 paired samples), as a sub-analysis of the SUPPORT trial (age 65.9 +/- 10.1 years). The GDF15 levels were analyzed across BMI groups (underweight [<18.5 kg/m2; n = 50], healthy weight [18.5-22.9; n = 27 5], overweight [23-24.9; n = 234], and obese [>=25; n = 381]), following WHO recommendations for the Asian-Pacific population. Landmark analysis at 3 years assessed the association between GDF15 levels and HF hospitalization or all-cause death.
+
+ RESULTS: Compared to the healthy weight group, the underweight group included more females (54.0%) with advanced HF (NYHA class III; 20.0%) and exhibited increased GDF15 level (1764 pg/mL [IQR 1067-2633]). Obese patients, younger (64.2 years) and diabetic (53%), had a similar GDF15 level to the healthy weight group. A higher baseline GDF15 level was associated with worse outcomes across the BMI spectrum. GDF15 increased by 208 [21-596] pg/mL over 3 years, with the most substantial increase observed in the underweight group (by +28.9% [6.2-81.0]). Persistently high GDF15 levels (>=1800 pg/mL) was independently associated with worse outcomes after 3 years (adjusted HR 1.8 [95%CI 1.1-2.9]).
+
+ CONCLUSIONS: In underweight patients with CHF, GDF15 level was elevated at baseline and experienced the most significant increase over 3 years. Its consistent elevation suggested a worse outcome. Copyright © 2023. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (GDF15 protein, human).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Multicenter Study.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.ijcard.2024.132093
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Teramoto&issn=0167-5273&title=International+Journal+of+Cardiology&atitle=Growth+differentiation+factor-15+and+metabolic+features+in+chronic+heart+failure%3A+Insights+from+the+SUPPORT+Trial+-GDF15+across+the+BMI+spectrum.&volume=407&issue=&spage=132093&epage=&date=2024&doi=10.1016%2Fj.ijcard.2024.132093&pmid=38663803&sid=OVID:medline
+
+<51>
+Unique Identifier
+ 38100820
+Title
+ Brief Report: Relationship Between Adiposity and Biomarkers of Aging and Frailty Among Adults Aging With HIV.
+Source
+ Journal of Acquired Immune Deficiency Syndromes: JAIDS. 95(4):377-382, 2024 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Oliveira VHF; Willig AL; Horvat Davey C; Buford TW; Menezes P; Cachay E; Crane HM; Burkholder GA; Gripshover BM; Fleming JG; Cleveland JD; Webel AR
+Author NameID
+ Oliveira, Vitor H F; ORCID: https://orcid.org/0000-0002-2273-1408
+Authors Full Name
+ Oliveira, Vitor H F; Willig, Amanda L; Horvat Davey, Christine; Buford, Thomas W; Menezes, Prema; Cachay, Edward; Crane, Heidi M; Burkholder, Greer A; Gripshover, Barbara M; Fleming, Julia G; Cleveland, John D; Webel, Allison R.
+Institution
+ Oliveira, Vitor H F. University of Washington, Seattle, WA.
+ Willig, Amanda L. University of Alabama at Birmingham, Birmingham, AL.
+ Horvat Davey, Christine. Case Western Reserve University, Cleveland, OH.
+ Buford, Thomas W. University of Alabama at Birmingham, Birmingham, AL.
+ Buford, Thomas W. Birmingham/Atlanta VA GRECC, Birmingham VA Medical Center, Birmingham, AL.
+ Menezes, Prema. The University of North Carolina at Chapel Hill, Chapel Hill, NC.
+ Cachay, Edward. University of California, San Diego, CA; and.
+ Crane, Heidi M. University of Washington, Seattle, WA.
+ Burkholder, Greer A. University of Alabama at Birmingham, Birmingham, AL.
+ Gripshover, Barbara M. Case Western Reserve University, Cleveland, OH.
+ Fleming, Julia G. Fenway Health, Boston, MA.
+ Cleveland, John D. University of Alabama at Birmingham, Birmingham, AL.
+ Webel, Allison R. University of Washington, Seattle, WA.
+MeSH Subject Headings
+ Adult
+ Male
+ Humans
+ Middle Aged
+ Female
+ Adiposity/ph [Physiology]
+ C-Reactive Protein/an [Analysis]
+ Hand Strength/ph [Physiology]
+ Cross-Sectional Studies
+ *Frailty
+ Tumor Necrosis Factor-alpha
+ HIV Infections/co [Complications]
+ *HIV Infections
+ Obesity
+ Aging/ph [Physiology]
+ Biomarkers/me [Metabolism]
+ Gonadal Steroid Hormones
+ Body Mass Index
+ Estradiol
+ Inflammation
+ Chemokines/me [Metabolism]
+ Dehydroepiandrosterone
+Abstract
+ BACKGROUND: This study examined the relationships among adiposity, handgrip, physical function, inflammation (ie, senescence-associated secretory phenotype chemokines as biomarkers of aging and frailty), and sex hormones in aging people with HIV.
+
+ METHODS: This cross-sectional exploratory study included 150 people with HIV aged >=40 years (67.3% of participants were male). Our measures included (1) body mass index and waist circumference as measures of adiposity; (2) handgrip as a measure of muscle strength; (3) short physical performance battery as a measure of physical function; (4) interleukin-6, tumor necrosis factor alpha receptor II, high sensitivity C-reactive protein, C-X-C motif chemokine 10, and C-X3-C motif chemokine ligand 1 also known as fractalkine as senescence-associated secretory phenotype chemokines; and (5) free testosterone, estradiol, sex hormone-binding globulin, and dehydroepiandrosterone as sex hormones. Quantile regression analyses were used to identify relationships among inflammatory markers and hormones with age, adiposity, handgrip, and physical function.
+
+ RESULTS: Overall, 74% (n = 111) of participants were classified as overweight or obese and 53.3% (n = 80) presented with abdominal obesity. After controlling for age and sex, body mass index was positively associated with estradiol (beta = 0.043, P < 0.01), and waist circumference was positively associated with high sensitivity C-reactive protein (beta = 2.151, P < 0.01). After controlling for sex, age was positively associated with C-X-C motif chemokine 10 (beta = 0.024, P = 0.03) and tumor necrosis factor alpha receptor II (beta = 2.205, P = 0.01). After controlling for age and sex, short physical performance battery was negatively associated with dehydroepiandrosterone (beta = -0.004, P = 0.01); no statistically significant associations were observed for handgrip.
+
+ CONCLUSION: Adiposity levels and aging were associated with inflammation (ie, C-X-C motif chemokine 10, tumor necrosis factor alpha receptor II, and high sensitivity C-reactive protein) among people with HIV aged 40 years and older. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Tumor Necrosis Factor-alpha). 0 (Biomarkers). 0 (Gonadal Steroid Hormones). 4TI98Z838E (Estradiol). 0 (Chemokines). 459AG36T1B (Dehydroepiandrosterone).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1097%2fQAI.0000000000003362
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Oliveira&issn=1525-4135&title=Journal+of+Acquired+Immune+Deficiency+Syndromes%3A+JAIDS&atitle=Brief+Report%3A+Relationship+Between+Adiposity+and+Biomarkers+of+Aging+and+Frailty+Among+Adults+Aging+With+HIV.&volume=95&issue=4&spage=377&epage=382&date=2024&doi=10.1097%2FQAI.0000000000003362&pmid=38100820&sid=OVID:medline
+
+<52>
+Unique Identifier
+ 38741154
+Title
+ Investigating a novel surrogate indicator of adipose accumulation in relation to erectile dysfunction.
+Source
+ Lipids in Health & Disease. 23(1):139, 2024 May 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Deng CY; Ke XP; Guo XG
+Authors Full Name
+ Deng, Chen-Yuan; Ke, Xin-Peng; Guo, Xu-Guang.
+Institution
+ Deng, Chen-Yuan. Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
+ Deng, Chen-Yuan. Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China.
+ Ke, Xin-Peng. Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China.
+ Guo, Xu-Guang. Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. gysygxg@gmail.com.
+ Guo, Xu-Guang. Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China. gysygxg@gmail.com.
+MeSH Subject Headings
+ Male
+ Erectile Dysfunction/me [Metabolism]
+ Erectile Dysfunction/pp [Physiopathology]
+ *Erectile Dysfunction
+ Humans
+ Middle Aged
+ *ROC Curve
+ Intra-Abdominal Fat/me [Metabolism]
+ Intra-Abdominal Fat/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ Adult
+ Homocysteine/bl [Blood]
+ Homocysteine/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Aged
+ Risk Factors
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/me [Metabolism]
+ Logistic Models
+Keyword Heading
+ Erectile dysfunction
+ METS-VF
+ NHANES
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Although previous studies have linked obesity and erectile dysfunction, the novel surrogate indicators of adipose accumulation are more essential and dependable factors to consider. Therefore, the primary objective of the current investigation was to examine and clarify the association between metabolic score for visceral fat (METS-VF) and erectile dysfunction.
+
+ METHODS: Firstly, multivariate logistic regression analysis, smoothed curve fitting, and threshold effect analysis were employed to investigate the association between METS-VF and erectile dysfunction. Mediation analysis was also performed to evaluate the mediating role of homocysteine and inflammation. After that, subgroup analysis was carried out to examine the stability of the correlation of METS-VF with erectile dysfunction in various population settings. Furthermore, the area under the receiver operating characteristic (ROC) curve and eXtreme Gradient Boosting (XGBoost) algorithm were utilized to assess the capability of identifying METS-VF in comparison to the other four obesity-related indicators in identifying erectile dysfunction.
+
+ RESULTS: After adjusting for all confounding factors, METS-VF was strongly and favourablely correlated with erectile dysfunction. With each additional unit rise in METS-VF, the prevalence of erectile dysfunction increased by 141%. A J-shaped relationship between METS-VF and erectile dysfunction was discovered through smoothed curve fitting. Marital status, physical activity, and smoking status can potentially modify this association. This finding of the ROC curve suggests that METS-VF had a powerful identifying capacity for erectile dysfunction (AUC = 0.7351). Homocysteine and inflammation mediated 4.24% and 2.81%, respectively.
+
+ CONCLUSION: The findings of the current investigation suggest that METS-VF can be considered a dependable identifying indicator of erectile dysfunction. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0LVT1QZ0BA (Homocysteine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12944-024-02118-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Deng&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Investigating+a+novel+surrogate+indicator+of+adipose+accumulation+in+relation+to+erectile+dysfunction.&volume=23&issue=1&spage=139&epage=&date=2024&doi=10.1186%2Fs12944-024-02118-9&pmid=38741154&sid=OVID:medline
+
+<53>
+Unique Identifier
+ 38677183
+Title
+ Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity.
+Source
+ EBioMedicine. 103:105127, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hateley C; Olona A; Halliday L; Edin ML; Ko JH; Forlano R; Terra X; Lih FB; Beltran-Debon R; Manousou P; Purkayastha S; Moorthy K; Thursz MR; Zhang G; Goldin RD; Zeldin DC; Petretto E; Behmoaras J
+Authors Full Name
+ Hateley, Charlotte; Olona, Antoni; Halliday, Laura; Edin, Matthew L; Ko, Jeong-Hun; Forlano, Roberta; Terra, Ximena; Lih, Fred B; Beltran-Debon, Raul; Manousou, Penelopi; Purkayastha, Sanjay; Moorthy, Krishna; Thursz, Mark R; Zhang, Guodong; Goldin, Robert D; Zeldin, Darryl C; Petretto, Enrico; Behmoaras, Jacques.
+Institution
+ Hateley, Charlotte. Centre for Inflammatory Disease, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK; Imperial College Healthcare NHS Trust, St. Mary's Hospital, Praed Street, London, W2 1NY, UK.
+ Olona, Antoni. Centre for Computational Biology and Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.
+ Halliday, Laura. Department of Surgery and Cancer, Imperial College London, UK.
+ Edin, Matthew L. Division of Intramural Research, NIEHS/NIH, Research Triangle Park, NC, USA.
+ Ko, Jeong-Hun. Division of Brain Sciences, Imperial College Faculty of Medicine, London, UK.
+ Forlano, Roberta. Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; Imperial College Healthcare NHS Trust, St. Mary's Hospital, Praed Street, London, W2 1NY, UK.
+ Terra, Ximena. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, MoBioFood Research Group, Tarragona, Spain.
+ Lih, Fred B. Division of Intramural Research, NIEHS/NIH, Research Triangle Park, NC, USA.
+ Beltran-Debon, Raul. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, MoBioFood Research Group, Tarragona, Spain.
+ Manousou, Penelopi. Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; Imperial College Healthcare NHS Trust, St. Mary's Hospital, Praed Street, London, W2 1NY, UK.
+ Purkayastha, Sanjay. Imperial College Healthcare NHS Trust, St. Mary's Hospital, Praed Street, London, W2 1NY, UK; University of Brunel, Kingston Lane, Uxbridge, London, UB8 3PH, UK.
+ Moorthy, Krishna. Department of Surgery and Cancer, Imperial College London, UK; Imperial College Healthcare NHS Trust, St. Mary's Hospital, Praed Street, London, W2 1NY, UK.
+ Thursz, Mark R. Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; Imperial College Healthcare NHS Trust, St. Mary's Hospital, Praed Street, London, W2 1NY, UK.
+ Zhang, Guodong. Department of Nutrition, College of Agriculture and Environmental Sciences, 3135 Meyer Hall, One Shields Avenue, UC Davis, Davis, CA, 95616, USA.
+ Goldin, Robert D. Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; Imperial College Healthcare NHS Trust, St. Mary's Hospital, Praed Street, London, W2 1NY, UK.
+ Zeldin, Darryl C. Division of Intramural Research, NIEHS/NIH, Research Triangle Park, NC, USA.
+ Petretto, Enrico. Centre for Computational Biology and Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore; Institute for Big Data and Artificial Intelligence in Medicine, School of Science, China Pharmaceutical University (CPU), Nanjing, China.
+ Behmoaras, Jacques. Centre for Inflammatory Disease, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK; Centre for Computational Biology and Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore. Electronic address: jacquesb@duke-nus.edu.sg.
+MeSH Subject Headings
+ Humans
+ Obesity/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity
+ Female
+ Fatty Liver/me [Metabolism]
+ Fatty Liver/pa [Pathology]
+ Fatty Liver/et [Etiology]
+ *Fatty Liver
+ Male
+ Oxylipins/me [Metabolism]
+ *Oxylipins
+ Adipose Tissue, White/me [Metabolism]
+ Adipose Tissue, White/pa [Pathology]
+ *Adipose Tissue, White
+ Middle Aged
+ Adult
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Biomarkers
+ Tandem Mass Spectrometry
+Keyword Heading
+ 12,13-EpOME:DiHOME
+ Diols
+ Epoxides
+ Metabolic syndrome
+ Obesity
+ Oxylipins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated loss of WAT homeostasis can trigger liver steatosis through dysregulated lipid pathways such as those related to polyunsaturated fatty acid (PUFA)-derived oxylipins. However, the exact relationship between oxylipins and metabolic syndrome remains elusive and cross-tissue dynamics of oxylipins are ill-defined.
+
+ METHODS: We quantified PUFA-related oxylipin species in the omental WAT, liver biopsies and plasma of 88 patients undergoing bariatric surgery (female N = 79) and 9 patients (female N = 4) undergoing upper gastrointestinal surgery, using UPLC-MS/MS. We integrated oxylipin abundance with WAT phenotypes (adipogenesis, adipocyte hypertrophy, macrophage infiltration, type I and VI collagen remodelling) and the severity of MASLD (steatosis, inflammation, fibrosis) quantified in each biopsy. The integrative analysis was subjected to (i) adjustment for known risk factors and, (ii) control for potential drug-effects through UPLC-MS/MS analysis of metformin-treated fat explants ex vivo.
+
+ FINDINGS: We reveal a generalized down-regulation of cytochrome P450 (CYP)-derived diols during obesity conserved between the WAT and plasma. Notably, epoxide:diol ratio, indicative of soluble epoxide hydrolyse (sEH) activity, increases with WAT inflammation/fibrosis, hepatic steatosis and T2DM. Increased 12,13-EpOME:DiHOME in WAT and liver is a marker of worsening metabolic syndrome in patients with obesity.
+
+ INTERPRETATION: These findings suggest a dampened sEH activity and a possible role of fatty acid diols during metabolic syndrome in major metabolic organs such as WAT and liver. They also have implications in view of the clinical trials based on sEH inhibition for metabolic syndrome.
+
+ FUNDING: Wellcome Trust (PS3431_WMIH); Duke-NUS (Intramural Goh Cardiovascular Research Award (Duke-NUS-GCR/2022/0020); National Medical Research Council (OFLCG22may-0011); National Institute of Environmental Health Sciences (Z01 ES025034); NIHR Imperial Biomedical Research Centre. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.ebiom.2024.105127
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hateley&issn=2352-3964&title=EBioMedicine&atitle=Multi-tissue+profiling+of+oxylipins+reveal+a+conserved+up-regulation+of+epoxide%3Adiol+ratio+that+associates+with+white+adipose+tissue+inflammation+and+liver+steatosis+in+obesity.&volume=103&issue=&spage=105127&epage=&date=2024&doi=10.1016%2Fj.ebiom.2024.105127&pmid=38677183&sid=OVID:medline
+
+<54>
+Unique Identifier
+ 38484979
+Title
+ Hepatic Effects of Low-Carbohydrate Diet Associated with Different Lipid Sources: Insights into Oxidative Stress, Cytotoxicity, and Epigenetic Markers in a mouse Model of Obesity.
+Source
+ Journal of Nutrition. 154(5):1517-1531, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Santamarina AB; Sertorio MN; Mennitti LV; Souza EA; Souza DV; Ribeiro DA; Pisani LP
+Authors Full Name
+ Santamarina, Aline Boveto; Sertorio, Marcela Nascimento; Mennitti, Lais Vales; Souza, Esther Alves de; Souza, Daniel Vitor de; Ribeiro, Daniel Araki; Pisani, Luciana Pellegrini.
+Institution
+ Santamarina, Aline Boveto. Department of Biosciences, Institute of Health and Society, Federal University of Sao Paulo (UNIFESP), Santos, Sao Paulo, Brazil.
+ Sertorio, Marcela Nascimento. Department of Biosciences, Institute of Health and Society, Federal University of Sao Paulo (UNIFESP), Santos, Sao Paulo, Brazil.
+ Mennitti, Lais Vales. Department of Biosciences, Institute of Health and Society, Federal University of Sao Paulo (UNIFESP), Santos, Sao Paulo, Brazil.
+ Souza, Esther Alves de. Department of Biosciences, Institute of Health and Society, Federal University of Sao Paulo (UNIFESP), Santos, Sao Paulo, Brazil.
+ Souza, Daniel Vitor de. Department of Biosciences, Institute of Health and Society, Federal University of Sao Paulo (UNIFESP), Santos, Sao Paulo, Brazil.
+ Ribeiro, Daniel Araki. Department of Biosciences, Institute of Health and Society, Federal University of Sao Paulo (UNIFESP), Santos, Sao Paulo, Brazil.
+ Pisani, Luciana Pellegrini. Department of Biosciences, Institute of Health and Society, Federal University of Sao Paulo (UNIFESP), Santos, Sao Paulo, Brazil. Electronic address: pisani@unifesp.br.
+MeSH Subject Headings
+ Animals
+ Oxidative Stress/de [Drug Effects]
+ *Oxidative Stress
+ Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ *Obesity
+ Male
+ Mice
+ *Epigenesis, Genetic
+ Liver/me [Metabolism]
+ Liver/de [Drug Effects]
+ *Liver
+ *Diet, Carbohydrate-Restricted
+ *Mice, Inbred C57BL
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ fatty acids
+ liver injury
+ low-carbohydrate diet
+ obesity
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Low-carbohydrate and high-fat diet (LCHF) models have been widely explored as alternatives for treating obesity and promoting weight loss. Their effect is attributed to the change in energy substrate that stimulates ketogenic pathways that can metabolically overload the liver. However, little has been studied about the impact of lipid sources prioritized in the LCHF diet.
+
+ OBJECTIVES: This study aims to evaluate the impact of different fat sources in the LCHF diet on markers of liver injury, oxidative stress, and epigenetics in obesity.
+
+ METHODS: Adult male mice were initially induced to obesity by a high-fat and high-sugar diet for 10 wk. Subsequently, they underwent a weight-loss treatment intervention involving an LCHF diet with various sources of fats, including saturated, omega-3 (omega-3) (n-3), omega-6 (omega-6) (n-6), and omega-9 (omega-9) (n-9). At the end of the treatment, markers of liver injury, oxidative stress, and epigenetics were evaluated.
+
+ RESULTS: The LCHF diet was effective in inducing weight loss. However, unsaturated lipid sources (omegas) exhibited superior outcomes. Specifically, the omega-9 group displayed diminished oxidative stress concentrations and decreased markers of liver injury. The omega-3 group demonstrated efficacy in modulating epigenetic markers, thereby reducing oxidative stress, mutagenicity, and markers of liver injury. Correlation tests demonstrated that there was an interaction between the activity of antioxidants and epigenetic enzymes.
+
+ CONCLUSIONS: Our results suggest that LCHF diets associated with omega-3 and omega-9 have the potential for weight loss and liver health recovery in obesity through antioxidant and epigenetic mechanisms. Copyright © 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.tjnut.2024.03.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Santamarina&issn=0022-3166&title=Journal+of+Nutrition&atitle=Hepatic+Effects+of+Low-Carbohydrate+Diet+Associated+with+Different+Lipid+Sources%3A+Insights+into+Oxidative+Stress%2C+Cytotoxicity%2C+and+Epigenetic+Markers+in+a+mouse+Model+of+Obesity.&volume=154&issue=5&spage=1517&epage=1531&date=2024&doi=10.1016%2Fj.tjnut.2024.03.007&pmid=38484979&sid=OVID:medline
+
+<55>
+Unique Identifier
+ 38527636
+Title
+ The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes.
+Source
+ Experimental Gerontology. 190:112410, 2024 Jun 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Memelink RG; Njemini R; de Bos Kuil MJJ; Wopereis S; de Vogel-van den Bosch J; Schoufour JD; Tieland M; Weijs PJM; Bautmans I
+Authors Full Name
+ Memelink, Robert G; Njemini, Rose; de Bos Kuil, Minse J J; Wopereis, Suzan; de Vogel-van den Bosch, Johan; Schoufour, Josje D; Tieland, Michael; Weijs, Peter J M; Bautmans, Ivan.
+Institution
+ Memelink, Robert G. Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences (AUAS), 1067 SM Amsterdam, the Netherlands; Amsterdam Movement Sciences research institute, Amsterdam UMC location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; Gerontology Department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, 1090 Brussels, Belgium. Electronic address: r.g.memelink@hva.nl.
+ Njemini, Rose. Frailty & Resilience in Ageing (FRIA) research department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
+ de Bos Kuil, Minse J J. Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences (AUAS), 1067 SM Amsterdam, the Netherlands.
+ Wopereis, Suzan. Research group Microbiology & Systems Biology, Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, the Netherlands.
+ de Vogel-van den Bosch, Johan. Danone Nutricia Research, 3584 CT Utrecht, the Netherlands.
+ Schoufour, Josje D. Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences (AUAS), 1067 SM Amsterdam, the Netherlands.
+ Tieland, Michael. Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences (AUAS), 1067 SM Amsterdam, the Netherlands.
+ Weijs, Peter J M. Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences (AUAS), 1067 SM Amsterdam, the Netherlands; Amsterdam Movement Sciences research institute, Amsterdam UMC location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; Department of Nutrition and Dietetics, Amsterdam University Medical Centers, VU University, 1081 HV Amsterdam, the Netherlands.
+ Bautmans, Ivan. Gerontology Department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, 1090 Brussels, Belgium; Frailty & Resilience in Ageing (FRIA) research department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, 1090 Brussels, Belgium; Department of Geriatrics, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium; SOMT University of Physiotherapy, 3821 BN Amersfoort, the Netherlands.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/th [Therapy]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2
+ Male
+ Female
+ Aged
+ Middle Aged
+ Inflammation/bl [Blood]
+ *Inflammation
+ Obesity/th [Therapy]
+ Obesity/bl [Blood]
+ *Obesity
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Resistance Training/mt [Methods]
+ Diet, Reducing/mt [Methods]
+ Cytokines/bl [Blood]
+ Life Style
+Keyword Heading
+ Ageing
+ Body composition
+ Chronic low-grade inflammatory profile
+ Type 2 diabetes
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D.
+
+ METHODS: In this post-hoc analysis of the PROBE study 114 adults (>=55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-alpha, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples. A linear mixed model was used to evaluate change in inflammatory biomarkers after lifestyle intervention and effect of the protein drink. Linear regression analysis was performed with parameters of body composition (by dual-energy X-ray absorptiometry) and parameters of insulin resistance (by oral glucose tolerance test).
+
+ RESULTS: There were no significant differences in CLIP responses between the protein and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 0.001 and p < 0.001), while ratios TNF-alpha/IL-10 and TNF-alpha/IL-1RA increased (p = 0.003 and p = 0.035). CRP increased by 12 % in participants with low to average CLIP (pre 1.91 +/- 0.39 mg/L, post 2.13 +/- 1.16 mg/L, p = 0.006) and decreased by 36 % in those with high CLIP (pre 5.14 mg/L +/- 1.20, post 3.30 +/- 2.29 mg/L, p < 0.001). Change in leptin and IL-1RA was positively associated with change in fat mass (beta = 0.133, p < 0.001; beta = 0.017, p < 0.001) and insulin resistance (beta = 0.095, p = 0.024; beta = 0.020, p = 0.001). Change in lean mass was not associated with any of the biomarkers.
+
+ CONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-alpha/IL-10 and TNF-alpha/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status. Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Randomized Controlled Trial.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.exger.2024.112410
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Memelink&issn=0531-5565&title=Experimental+Gerontology&atitle=The+effect+of+a+combined+lifestyle+intervention+with+and+without+protein+drink+on+inflammation+in+older+adults+with+obesity+and+type+2+diabetes.&volume=190&issue=&spage=112410&epage=&date=2024&doi=10.1016%2Fj.exger.2024.112410&pmid=38527636&sid=OVID:medline
+
+<56>
+Unique Identifier
+ 38732626
+Title
+ Evaluation of the Diagnostic Utility of Selected Serum Adipokines and Cytokines in Subjects with MASLD-A Pilot Study.
+Source
+ Nutrients. 16(9), 2024 May 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zysk B; Ostrowska L; Smarkusz-Zarzecka J; Orywal K; Mroczko B; Cwalina U
+Author NameID
+ Zysk, Beata; ORCID: https://orcid.org/0000-0002-9821-9347
+ Ostrowska, Lucyna; ORCID: https://orcid.org/0000-0002-0543-1817
+ Smarkusz-Zarzecka, Joanna; ORCID: https://orcid.org/0000-0003-3504-951X
+ Orywal, Karolina; ORCID: https://orcid.org/0000-0001-5992-8098
+ Mroczko, Barbara; ORCID: https://orcid.org/0000-0002-4075-8479
+ Cwalina, Urszula; ORCID: https://orcid.org/0000-0003-0832-6593
+Authors Full Name
+ Zysk, Beata; Ostrowska, Lucyna; Smarkusz-Zarzecka, Joanna; Orywal, Karolina; Mroczko, Barbara; Cwalina, Urszula.
+Institution
+ Zysk, Beata. Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Mieszka I 4B Street, 15-054 Bialystok, Poland.
+ Ostrowska, Lucyna. Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Mieszka I 4B Street, 15-054 Bialystok, Poland.
+ Smarkusz-Zarzecka, Joanna. Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Mieszka I 4B Street, 15-054 Bialystok, Poland.
+ Orywal, Karolina. Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A Street, 15-269 Bialystok, Poland.
+ Mroczko, Barbara. Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A Street, 15-269 Bialystok, Poland.
+ Cwalina, Urszula. Department of Biostatistics and Medical Informatics, Medical University of Bialystok, Szpitalna 37 Street, 15-295 Bialystok, Poland.
+MeSH Subject Headings
+ Humans
+ Female
+ Male
+ Pilot Projects
+ Adipokines/bl [Blood]
+ *Adipokines
+ Middle Aged
+ Cytokines/bl [Blood]
+ *Cytokines
+ Adult
+ Obesity/bl [Blood]
+ *Obesity
+ Body Mass Index
+ Biomarkers/bl [Blood]
+ Fatty Liver/bl [Blood]
+ Fatty Liver/di [Diagnosis]
+ Interleukin-6/bl [Blood]
+ Intra-Abdominal Fat/me [Metabolism]
+ Interleukin-1beta/bl [Blood]
+ Body Composition
+ Insulin Resistance
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+Keyword Heading
+ Il-1beta
+ Il-6
+ MASLD
+ NAFLD
+ VAT
+ adipokines
+ adipose tissue
+ cytokines
+ hepatic steatosis
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Excess adipose tissue, particularly of the visceral type, triggering chronic low-grade inflammation and altering its secretory profile, is a contributing factor to the initiation and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to compare the levels of selected adipokines and cytokines in individuals with normal weight and obesity, assessing their potential for diagnosing MASLD and establishing a cutoff point for body fat content associated with hepatic steatosis development. The research involved 99 participants categorized by body mass index and MASLD presence, undergoing body composition analysis, liver elastography, biochemical tests, and evaluation of adipokines and cytokines in serum. The results indicated elevated IL-6 (interleukin 6) serum levels in individuals with obesity with MASLD compared to the normal-weight group without MASLD. The multivariate regression analysis demonstrated a connection between hepatic steatosis and total adipose tissue content, VAT (visceral adipose tissue), VAT/SAT (subcutaneous adipose tissue) ratio, HOMA-IR (homeostasis model assessment of insulin resistance), IL-6, Il-1beta (interleukin 1beta), and MMP-2 (matrix metalloproteinase 2). Among the adipokines and cytokines examined in this study, interleukin 6 was the strongest predictor of MASLD regardless of gender. In addition, an association between the development of hepatic steatosis and higher serum IL-1beta levels and higher adipose tissue was observed in women. However, further studies on a larger group of patients are needed to consider the use of these cytokines as markers of MASLD. The HOMA-IR index demonstrated potential diagnostic utility in identifying hepatic steatosis.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Cytokines). 0 (Biomarkers). 0 (Interleukin-6). 0 (Interleukin-1beta).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu16091381
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zysk&issn=2072-6643&title=Nutrients&atitle=Evaluation+of+the+Diagnostic+Utility+of+Selected+Serum+Adipokines+and+Cytokines+in+Subjects+with+MASLD-A+Pilot+Study.&volume=16&issue=9&spage=&epage=&date=2024&doi=10.3390%2Fnu16091381&pmid=38732626&sid=OVID:medline
+
+<57>
+Unique Identifier
+ 38732557
+Title
+ Triglyceride to HDL Cholesterol Ratio for the Identification of MASLD in Obesity: A Liver Biopsy-Based Case-Control Study.
+Source
+ Nutrients. 16(9), 2024 Apr 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Martinez-Montoro JI; Martinez-Sanchez MA; Balaguer-Roman A; Fernandez-Ruiz VE; Hernandez-Barcelo JE; Ferrer-Gomez M; Frutos MD; Nunez-Sanchez MA; Fernandez-Garcia JC; Ramos-Molina B
+Author NameID
+ Martinez-Montoro, Jose Ignacio; ORCID: https://orcid.org/0000-0001-9761-6888
+ Balaguer-Roman, Andres; ORCID: https://orcid.org/0000-0002-5297-0194
+ Frutos, Maria Dolores; ORCID: https://orcid.org/0000-0002-2111-4715
+ Nunez-Sanchez, Maria Angeles; ORCID: https://orcid.org/0000-0002-8938-2767
+ Ramos-Molina, Bruno; ORCID: https://orcid.org/0000-0001-6804-5449
+Authors Full Name
+ Martinez-Montoro, Jose Ignacio; Martinez-Sanchez, Maria Antonia; Balaguer-Roman, Andres; Fernandez-Ruiz, Virginia Esperanza; Hernandez-Barcelo, Jose Emilio; Ferrer-Gomez, Mercedes; Frutos, Maria Dolores; Nunez-Sanchez, Maria Angeles; Fernandez-Garcia, Jose Carlos; Ramos-Molina, Bruno.
+Institution
+ Martinez-Montoro, Jose Ignacio. Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Faculty of Medicine, University of Malaga, 29010 Malaga, Spain.
+ Martinez-Sanchez, Maria Antonia. Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain.
+ Balaguer-Roman, Andres. Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain.
+ Balaguer-Roman, Andres. Department of General and Digestive System Surgery, Virgen de la Arrixaca University Hospital, 30120 Murcia, Spain.
+ Fernandez-Ruiz, Virginia Esperanza. Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain.
+ Fernandez-Ruiz, Virginia Esperanza. Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Hospital, 30120 Murcia, Spain.
+ Hernandez-Barcelo, Jose Emilio. Department of Pathology, Virgen de la Arrixaca University Hospital, 30120 Murcia, Spain.
+ Ferrer-Gomez, Mercedes. Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain.
+ Ferrer-Gomez, Mercedes. Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Hospital, 30120 Murcia, Spain.
+ Frutos, Maria Dolores. Department of General and Digestive System Surgery, Virgen de la Arrixaca University Hospital, 30120 Murcia, Spain.
+ Nunez-Sanchez, Maria Angeles. Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain.
+ Fernandez-Garcia, Jose Carlos. Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Faculty of Medicine, University of Malaga, 29010 Malaga, Spain.
+ Ramos-Molina, Bruno. Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain.
+MeSH Subject Headings
+ Humans
+ Cholesterol, HDL/bl [Blood]
+ *Cholesterol, HDL
+ Triglycerides/bl [Blood]
+ *Triglycerides
+ Female
+ Male
+ Case-Control Studies
+ Middle Aged
+ Liver/pa [Pathology]
+ *Liver
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity
+ Biopsy
+ Fatty Liver/bl [Blood]
+ Fatty Liver/di [Diagnosis]
+ *Fatty Liver
+ Adult
+ Biomarkers/bl [Blood]
+ ROC Curve
+ Dyslipidemias/bl [Blood]
+Keyword Heading
+ TG/HDL-C ratio
+ liver biopsy
+ metabolic dysfunction-associated steatohepatitis
+ metabolic dysfunction-associated steatotic liver disease
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Associations between dyslipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. Previous studies have shown that the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio may be a surrogate marker of MASLD, assessed by liver ultrasound. However, no studies have evaluated the utility of this ratio according to biopsy-proven MASLD and its stages. Therefore, our aim was to evaluate if the TG/HDL-C ratio allows for the identification of biopsy-proven MASLD in patients with obesity. We conducted a case-control study in 153 patients with obesity who underwent metabolic surgery and had a concomitant liver biopsy. Fifty-three patients were classified as no MASLD, 45 patients as metabolic dysfunction-associated steatotic liver-MASL, and 55 patients as metabolic dysfunction-associated steatohepatitis-MASH. A receiver operating characteristic (ROC) analysis was performed to assess the accuracy of the TG/HDL-C ratio to detect MASLD. We also compared the area under the curve (AUC) of the TG/HDL-C ratio, serum TG, and HDL-C. A higher TG/HDL-C ratio was observed among patients with MASLD, compared with patients without MASLD. No differences in the TG/HDL-C ratio were found between participants with MASL and MASH. The greatest AUC was observed for the TG/HDL-C ratio (AUC 0.747, p < 0.001) with a cut-off point of 3.7 for detecting MASLD (sensitivity = 70%; specificity = 74.5%). However, no statistically significant differences between the AUC of the TG/HDL-C ratio and TG or HDL-C were observed to detect MASLD. In conclusion, although an elevated TG/HDL-C ratio can be found in patients with MASLD, this marker did not improve the detection of MASLD in our study population, compared with either serum TG or HDL-C.
+Registry Number/Name of Substance
+ 0 (Cholesterol, HDL). 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu16091310
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Martinez-Montoro&issn=2072-6643&title=Nutrients&atitle=Triglyceride+to+HDL+Cholesterol+Ratio+for+the+Identification+of+MASLD+in+Obesity%3A+A+Liver+Biopsy-Based+Case-Control+Study.&volume=16&issue=9&spage=&epage=&date=2024&doi=10.3390%2Fnu16091310&pmid=38732557&sid=OVID:medline
+
+<58>
+Unique Identifier
+ 38732147
+Title
+ A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1.
+Source
+ International Journal of Molecular Sciences. 25(9), 2024 Apr 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gadd G; Aberg D; Wall A; Zetterberg H; Blennow K; Jood K; Jern C; Isgaard J; Svensson J; Aberg ND
+Author NameID
+ Aberg, Daniel; ORCID: https://orcid.org/0000-0003-0517-6331
+ Wall, Alexander; ORCID: https://orcid.org/0000-0001-7683-160X
+ Aberg, N David; ORCID: https://orcid.org/0000-0002-1474-5666
+Authors Full Name
+ Gadd, Gustaf; Aberg, Daniel; Wall, Alexander; Zetterberg, Henrik; Blennow, Kaj; Jood, Katarina; Jern, Christina; Isgaard, Jorgen; Svensson, Johan; Aberg, N David.
+Institution
+ Gadd, Gustaf. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
+ Gadd, Gustaf. Region Vastra Gotaland, Department of Acute Medicine and Geriatrics, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
+ Aberg, Daniel. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
+ Aberg, Daniel. Region Vastra Gotaland, Department of Specialist Medicine, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
+ Wall, Alexander. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
+ Wall, Alexander. Narhalsan, Region Vastra Gotaland, 411 04 Gothenburg, Sweden.
+ Zetterberg, Henrik. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 431 80 Molndal, Sweden.
+ Zetterberg, Henrik. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 431 41 Molndal, Sweden.
+ Zetterberg, Henrik. Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1E 6BT, UK.
+ Zetterberg, Henrik. Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
+ Zetterberg, Henrik. Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53707, USA.
+ Zetterberg, Henrik. UK Dementia Research Institute, University College London (UCL), London WC1E 6BT, UK.
+ Blennow, Kaj. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 431 80 Molndal, Sweden.
+ Blennow, Kaj. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 431 41 Molndal, Sweden.
+ Blennow, Kaj. Paris Brain Institute, ICM, Pitie-Salpetriere Hospital, Sorbonne University, 75005 Paris, France.
+ Blennow, Kaj. Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei 230001, China.
+ Jood, Katarina. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
+ Jood, Katarina. Region Vastra Gotaland, Department of Neurology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
+ Jern, Christina. Institute of Biomedicine, Department of Laboratory Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
+ Jern, Christina. Region Vastra Gotaland, Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
+ Isgaard, Jorgen. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
+ Isgaard, Jorgen. Region Vastra Gotaland, Department of Specialist Medicine, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
+ Svensson, Johan. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
+ Svensson, Johan. Region Vastra Gotaland, Department of Internal Medicine, Skaraborg Central Hospital, 549 49 Skovde, Sweden.
+ Aberg, N David. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
+ Aberg, N David. Region Vastra Gotaland, Department of Acute Medicine and Geriatrics, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
+MeSH Subject Headings
+ Humans
+ *Insulin Resistance
+ *Body Mass Index
+ Female
+ Male
+ Aged
+ Insulin-Like Growth Factor Binding Protein 1/bl [Blood]
+ Insulin-Like Growth Factor Binding Protein 1/me [Metabolism]
+ *Insulin-Like Growth Factor Binding Protein 1
+ Inflammation/me [Metabolism]
+ Inflammation/bl [Blood]
+ *Inflammation
+ Middle Aged
+ Obesity/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/bl [Blood]
+ Stroke/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Overweight/me [Metabolism]
+ Overweight/bl [Blood]
+ Insulin-Like Peptides
+Keyword Heading
+ body mass index (BMI)
+ homeostasis model assessment of insulin resistance (HOMA-IR)
+ insulin-like growth factor-binding protein-1 (IGFBP-1)
+ modified Rankin Score (mRS)
+ obesity paradox
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Both high serum insulin-like growth factor-binding protein-1 (s-IGFBP-1) and insulin resistance (IR) are associated with poor functional outcome poststroke, whereas overweight body mass index (BMI; 25-30) is related to fewer deaths and favorable functional outcome in a phenomenon labeled "the obesity paradox". Furthermore, IGFBP-1 is inversely related to BMI, in contrast to the linear relation between IR and BMI. Here, we investigated s-IGFBP-1 and IR concerning BMI and 7-year poststroke functional outcome. We included 451 stroke patients from the Sahlgrenska Study on Ischemic Stroke (SAHLSIS) with baseline measurements of s-IGFBP1, homeostasis model assessment of IR (HOMA-IR), BMI (categories: normal-weight (8.5-25), overweight (25-30), and obesity (>30)), and high-sensitivity C-reactive protein (hs-CRP) as a measure of general inflammation. Associations with poor functional outcome (modified Rankin scale [mRS] score: 3-6) after 7 years were evaluated using multivariable binary logistic regression, with overweight as reference due to the nonlinear relationship. Both normal-weight (odds-ratio [OR] 2.32, 95% confidence interval [CI] 1.30-4.14) and obese (OR 2.25, 95% CI 1.08-4.71) patients had an increased risk of poor functional outcome, driven by deaths only in the normal-weight. In normal-weight, s-IGFBP-1 modestly attenuated (8.3%) this association. In the obese, the association was instead attenuated by HOMA-IR (22.4%) and hs-CRP (10.4%). Thus, a nonlinear relation between BMI and poor 7-year functional outcome was differently attenuated in the normal-weight and the obese.
+Registry Number/Name of Substance
+ 0 (Insulin-Like Growth Factor Binding Protein 1). 9007-41-4 (C-Reactive Protein). 0 (IGFBP1 protein, human). 0 (Biomarkers). 0 (Insulin-Like Peptides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fijms25094931
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gadd&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=A+Nonlinear+Relation+between+Body+Mass+Index+and+Long-Term+Poststroke+Functional+Outcome-The+Importance+of+Insulin+Resistance%2C+Inflammation%2C+and+Insulin-like+Growth+Factor-Binding+Protein-1.&volume=25&issue=9&spage=4931&epage=&date=2024&doi=10.3390%2Fijms25094931&pmid=38732147&sid=OVID:medline
+
+<59>
+Unique Identifier
+ 38732002
+Title
+ Examination of the Complex Molecular Landscape in Obesity and Type 2 Diabetes.
+Source
+ International Journal of Molecular Sciences. 25(9), 2024 Apr 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vadadokhau U; Varga I; Kaplar M; Emri M; Csosz E
+Author NameID
+ Vadadokhau, Uladzislau; ORCID: https://orcid.org/0000-0003-3773-7746
+ Varga, Imre; ORCID: https://orcid.org/0000-0003-3921-2521
+ Csosz, Eva; ORCID: https://orcid.org/0000-0003-4373-2175
+Authors Full Name
+ Vadadokhau, Uladzislau; Varga, Imre; Kaplar, Miklos; Emri, Miklos; Csosz, Eva.
+Institution
+ Vadadokhau, Uladzislau. Proteomics Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
+ Vadadokhau, Uladzislau. Doctoral School of Molecular Cellular and Immune Biology, University of Debrecen, 4032 Debrecen, Hungary.
+ Varga, Imre. Department of IT Systems and Networks, Faculty of Informatics, University of Debrecen, 4028 Debrecen, Hungary.
+ Kaplar, Miklos. Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
+ Emri, Miklos. Department of Medical Imaging, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
+ Csosz, Eva. Proteomics Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
+MeSH Subject Headings
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2
+ Humans
+ Obesity/me [Metabolism]
+ Obesity/ge [Genetics]
+ *Obesity
+ *Biomarkers
+ Proteomics/mt [Methods]
+ *Proteomics
+ Metabolomics/mt [Methods]
+ *Metabolomics
+ Male
+ Female
+ Middle Aged
+Keyword Heading
+ data integration
+ metabolomics
+ obesity
+ proteomics
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The escalating prevalence of metabolic disorders, notably type 2 diabetes (T2D) and obesity, presents a critical global health challenge, necessitating deeper insights into their molecular underpinnings. Our study integrates proteomics and metabolomics analyses to delineate the complex molecular landscapes associated with T2D and obesity. Leveraging data from 130 subjects, including individuals with T2D and obesity as well as healthy controls, we elucidate distinct molecular signatures and identify novel biomarkers indicative of disease progression. Our comprehensive characterization of cardiometabolic proteins and serum metabolites unveils intricate networks of biomolecular interactions and highlights differential protein expression patterns between T2D and obesity cohorts. Pathway enrichment analyses reveal unique mechanisms underlying disease development and progression, while correlation analyses elucidate the interplay between proteomics, metabolomics, and clinical parameters. Furthermore, network analyses underscore the interconnectedness of cardiometabolic proteins and provide insights into their roles in disease pathogenesis. Our findings may help to refine diagnostic strategies and inform the development of personalized interventions, heralding a new era in precision medicine and healthcare innovation. Through the integration of multi-omics approaches and advanced analytics, our study offers a crucial framework for deciphering the intricate molecular underpinnings of metabolic disorders and paving the way for transformative therapeutic strategies.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fijms25094781
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vadadokhau&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Examination+of+the+Complex+Molecular+Landscape+in+Obesity+and+Type+2+Diabetes.&volume=25&issue=9&spage=4781&epage=&date=2024&doi=10.3390%2Fijms25094781&pmid=38732002&sid=OVID:medline
+
+<60>
+Unique Identifier
+ 38731797
+Title
+ Investigating the Role of FABP4 in Diabetes and Obesity and the Influence of Age and Ethnicity: A Comprehensive Analysis of a Cohort from the KEDP-Study.
+Source
+ International Journal of Molecular Sciences. 25(9), 2024 Apr 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abdalla MA; Abubaker J; Abu-Farha M; Al-Khairi I; Cherian P; Qaddoumi MG; Al-Rashed F; Thanaraj TA; Albatineh AN; Al-Mulla F
+Author NameID
+ Abdalla, Mohammed A; ORCID: https://orcid.org/0000-0002-6016-3157
+ Abubaker, Jehad; ORCID: https://orcid.org/0000-0003-0681-7305
+ Abu-Farha, Mohamed; ORCID: https://orcid.org/0000-0001-8357-1252
+ Al-Khairi, Irina; ORCID: https://orcid.org/0000-0002-3547-9926
+ Al-Rashed, Fatema; ORCID: https://orcid.org/0000-0002-5825-7701
+ Thanaraj, Thangavel Alphonse; ORCID: https://orcid.org/0000-0002-4574-5343
+ Al-Mulla, Fahd; ORCID: https://orcid.org/0000-0001-5409-3829
+Authors Full Name
+ Abdalla, Mohammed A; Abubaker, Jehad; Abu-Farha, Mohamed; Al-Khairi, Irina; Cherian, Preethi; Qaddoumi, Mohammad G; Al-Rashed, Fatema; Thanaraj, Thangavel Alphonse; Albatineh, Ahmed N; Al-Mulla, Fahd.
+Institution
+ Abdalla, Mohammed A. Department of Translational Research, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Abdalla, Mohammed A. Hull York Medical School (HYMS), University of Hull, Hull HU6 7RX, UK.
+ Abubaker, Jehad. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Abu-Farha, Mohamed. Department of Translational Research, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Abu-Farha, Mohamed. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Al-Khairi, Irina. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Cherian, Preethi. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Qaddoumi, Mohammad G. Pharmacology and Therapeutics Department, Faculty of Pharmacy, Kuwait University, Kuwait City 13110, Kuwait.
+ Al-Rashed, Fatema. Department of Immunology & Microbiology, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City 15462, Kuwait.
+ Thanaraj, Thangavel Alphonse. Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Albatineh, Ahmed N. Faculty of Medicine, Kuwait University, Kuwait City 13110, Kuwait.
+ Al-Mulla, Fahd. Department of Translational Research, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+MeSH Subject Headings
+ Humans
+ Fatty Acid-Binding Proteins/bl [Blood]
+ Fatty Acid-Binding Proteins/me [Metabolism]
+ *Fatty Acid-Binding Proteins
+ Male
+ Female
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/me [Metabolism]
+ *Obesity
+ Adult
+ Cohort Studies
+ Age Factors
+ Aged
+ Ethnicity
+ Body Mass Index
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+Keyword Heading
+ BMI
+ FABP4
+ FBG
+ HbA1c
+ diabetes
+ ethnicity
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipocyte P2 (aP2), also known as FABP4, is an adipokine that adipose tissue produces and expresses in macrophages. Its primary role is to facilitate the transportation of fatty acids across cell membranes. Numerous studies have reported associations between FABP4 and the development of metabolic disorders. However, there is limited knowledge regarding FABP4 expression in diabetes and obesity, especially about different age groups, genders, and ethnicities. This study aims to investigate the association between FABP4 levels, diabetes mellitus, and obesity within various ethnic groups. We measured plasma FABP4 concentrations in a cohort of 2083 patients from the KDEP study and gathered anthropometric data. Additionally, we collected and analyzed clinical, biochemical, and glycemic markers using multivariate regression analysis. The average FABP4 concentration was significantly higher in female participants than in males (18.8 ng/mL vs. 14.4 ng/mL, p < 0.001, respectively), and in those over 50 years old compared to those under 50 years of age (19.3 ng/mL vs. 16.2 ng/mL, p < 0.001, respectively). In this study, significant positive associations were found between the plasma level of FABP4 and obesity markers: BMI (r = 0.496, p < 0.001), hip circumference (r = 0.463, p < 0.001), and waist circumference (WC) (r = 0.436, p < 0.001). Similar observations were also seen with glycemic markers, which included HbA1c (r = 0.126, p < 0.001), fasting blood glucose (FBG) (r = 0.184, p < 0.001), fasting insulin (r = 0.326, p < 0.001), and HOMA-IR (r = 0.333, p < 0.001). Importantly, these associations remained significant even after adjusting for age, gender, and ethnicity. Furthermore, FABP4 levels were negatively associated with male gender (beta: -3.85, 95% CI: -4.92, -2.77, p < 0.001), and positively associated with age (beta: 0.14, 95% CI: 0.096, 0.183, p < 0.001), BMI (beta: 0.74, 95% CI: 0.644, 0.836, p < 0.001), and fasting insulin (beta: 0.115, 95% CI: 0.091, 0.138, p < 0.001). In this study, plasma FABP4 levels were significantly higher in diabetic and obese participants, and they were strongly influenced by age, gender, and ethnicity. These findings suggest that FABP4 may serve as a valuable prognostic and diagnostic marker for obesity and diabetes, particularly among female patients, individuals over 50 years old, and specific ethnic groups.
+Registry Number/Name of Substance
+ 0 (Fatty Acid-Binding Proteins). 0 (FABP4 protein, human). 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fijms25094578
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abdalla&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Investigating+the+Role+of+FABP4+in+Diabetes+and+Obesity+and+the+Influence+of+Age+and+Ethnicity%3A+A+Comprehensive+Analysis+of+a+Cohort+from+the+KEDP-Study.&volume=25&issue=9&spage=4578&epage=&date=2024&doi=10.3390%2Fijms25094578&pmid=38731797&sid=OVID:medline
+
+<61>
+Unique Identifier
+ 38716942
+Title
+ Evaluation of mucin-1, nuclear factor kappaB, and hemoglobin A1c levels in obese and non-obese individuals.
+Source
+ Revista Da Associacao Medica Brasileira. 70(4):e20231214, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fadiloglu M; Bozkurt AS; Akarsu E; Yilmaz SG; Sayiner ZA; Ulusal H
+Author NameID
+ Fadiloglu, Mujde; ORCID: http://orcid.org/0009-0007-6326-3720
+ Bozkurt, Ahmet Sarper; ORCID: http://orcid.org/0000-0002-7293-0974
+ Akarsu, Ersin; ORCID: http://orcid.org/0000-0003-2786-6616
+ Yilmaz, Senay Gorucu; ORCID: http://orcid.org/0000-0003-0523-7819
+ Sayiner, Zeynel Abidin; ORCID: http://orcid.org/0000-0001-5105-0292
+ Ulusal, Hasan; ORCID: http://orcid.org/0000-0003-3890-2088
+Authors Full Name
+ Fadiloglu, Mujde; Bozkurt, Ahmet Sarper; Akarsu, Ersin; Yilmaz, Senay Gorucu; Sayiner, Zeynel Abidin; Ulusal, Hasan.
+Institution
+ Fadiloglu, Mujde. Gaziantep University, Medicine Faculty, Department of Physiology - Gaziantep, Turkey.
+ Bozkurt, Ahmet Sarper. Gaziantep University, Medicine Faculty, Department of Physiology - Gaziantep, Turkey.
+ Akarsu, Ersin. Gaziantep University, Medicine Faculty, Department of Endocrinology and Metabolism - Gaziantep, Turkey.
+ Yilmaz, Senay Gorucu. Gaziantep University, Faculty of Health Sciences, Department of Nutrition and Dietetics - Gaziantep, Turkey.
+ Sayiner, Zeynel Abidin. Gaziantep University, Medicine Faculty, Department of Endocrinology and Metabolism - Gaziantep, Turkey.
+ Ulusal, Hasan. Gaziantep University, Faculty of Medicine, Department of Medical Biochemistry - Gaziantep, Turkey.
+MeSH Subject Headings
+ Humans
+ Male
+ Obesity/bl [Blood]
+ *Obesity
+ Female
+ Glycated Hemoglobin/an [Analysis]
+ *Glycated Hemoglobin
+ Adult
+ NF-kappa B/bl [Blood]
+ *NF-kappa B
+ Case-Control Studies
+ Middle Aged
+ Young Adult
+ Mucin-1/bl [Blood]
+ *Mucin-1
+ Adolescent
+ *Body Mass Index
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Enzyme-Linked Immunosorbent Assay
+ Real-Time Polymerase Chain Reaction
+Abstract
+ OBJECTIVE: Obesity is a chronic multisystem disease associated with increased morbidity and mortality. Obesity, which is a complex, multifactorial, and heterogeneous condition, is thought to result from the interaction of environmental, physiological, and genetic factors. In this study, the relationship between serum levels of hemoglobin A1c, mucin-1, and nuclear factor kappaB in obese and healthy cohorts was evaluated along with biochemical and gene expressions and with demographic and clinical covariates, and their effects on obesity were evaluated.
+
+ METHODS: This case-control study included a total of 80 individuals, 40 healthy controls and 40 obesity patients, consisting of female and male aged between 18 and 63 years. Hemoglobin A1c, mucin-1, and nuclear factor kappaB levels were determined by ELISA in serum samples obtained from patients. In addition, aspartate aminotransferase, alanine transaminase, low density lipoprotein, and glucose values were measured. The gene expressions of the same markers were analyzed by quantitative real-time polymerase chain reaction, and their regulation status was defined.
+
+ RESULTS: Serum levels of hemoglobin A1c, mucin-1, and nuclear factor kappaB were found to be high in obese individuals (p<0.05). The gene expression of these serum markers was found to be upregulated. Of the anthropometric measurements, waist circumference and body mass index were correlated with both serum markers and gene expressions (p<0.05).
+
+ CONCLUSION: In addition to the known association of hemoglobin A1c and nuclear factor kappaB with obesity, serum levels of mucin-1 as well as upregulation of genes point to its modifier effect on obesity. These parameters can be the powerful markers in the diagnosis of obesity.
+Registry Number/Name of Substance
+ 0 (Glycated Hemoglobin). 0 (NF-kappa B). 0 (Mucin-1). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1590%2f1806-9282.20231214
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fadiloglu&issn=0104-4230&title=Revista+Da+Associacao+Medica+Brasileira&atitle=Evaluation+of+mucin-1%2C+nuclear+factor+kappaB%2C+and+hemoglobin+A1c+levels+in+obese+and+non-obese+individuals.&volume=70&issue=4&spage=e20231214&epage=&date=2024&doi=10.1590%2F1806-9282.20231214&pmid=38716942&sid=OVID:medline
+
+<62>
+Unique Identifier
+ 38156530
+Title
+ Increased body mass index is negatively associated with ovarian reserve as measured by anti-Mullerian hormone in patients with polycystic ovarian syndrome.
+Source
+ Clinical Obesity. 14(3):e12638, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kloos J; Perez J; Weinerman R
+Author NameID
+ Kloos, Jacqueline; ORCID: https://orcid.org/0000-0002-9196-7887
+Authors Full Name
+ Kloos, Jacqueline; Perez, Jaime; Weinerman, Rachel.
+Institution
+ Kloos, Jacqueline. Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
+ Perez, Jaime. Clinical Research Center, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
+ Weinerman, Rachel. Division of Reproductive Endocrinology and Infertility, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
+MeSH Subject Headings
+ Humans
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/co [Complications]
+ Polycystic Ovary Syndrome/pp [Physiopathology]
+ *Polycystic Ovary Syndrome
+ Female
+ Anti-Mullerian Hormone/bl [Blood]
+ *Anti-Mullerian Hormone
+ *Body Mass Index
+ Adult
+ Ovarian Reserve/ph [Physiology]
+ *Ovarian Reserve
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ Retrospective Studies
+Keyword Heading
+ AMH
+ endocrinology
+ fertility
+ obesity
+ polycystic ovarian syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Anti-Mullerian hormone (AMH) is commonly used as a marker of ovarian reserve. Although obesity is associated with decreased fertility, the relationship between body mass index (BMI) and AMH remains uncertain, hindering the accurate interpretation of AMH. We sought to assess the relationship between serum AMH and BMI in patients with and without polycystic ovarian syndrome (PCOS). This study analysed 500 patients at a single centre between 2020 and 2021. Patients were divided into cohorts: those with BMI <40 kg/m2 and those with BMI >40 kg/m2. Patients with and without PCOS were included. Chi-square tests, Fisher's exact tests, multiple linear regression analysis and independent t-tests were performed as appropriate. In the general study population, serum AMH was not significantly different in the BMI >40 kg/m2 group compared to the BMI <40 kg/m2 group (4.3 +/- 5.6 vs. 4.3 +/- 5.6, p = .35). Patient ages between these two groups differed, with an average age of 35.4 +/- 5.4 years in the BMI <40 kg/m2 group and 33.7 +/- 5.4 years in the BMI <40 kg/m2 group (p = .031). Our multivariate regression analysis, which adjusted for age, demonstrated a significant interaction effect between BMI and PCOS diagnosis, indicating that the relationship between BMI and AMH is dependent on PCOS status (beta = -.03, 95% confidence interval [CI]: -0.05, 0.00, p = .044). In patients without PCOS, we found a non-significant relationship between AMH and BMI (beta = .00, 95% CI -0.01, 0.01, p = .7); however, in patients with PCOS, AMH significantly decreased as BMI increased (beta = -.03, 95% CI -0.06, 0.00, p = .034). BMI has an inverse association with AMH levels in patients with PCOS, indicating a need for future research to determine if that interaction represents a clinically significant negative effect on reproductive function. Copyright © 2023 The Authors. Clinical Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
+Registry Number/Name of Substance
+ 80497-65-0 (Anti-Mullerian Hormone). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fcob.12638
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kloos&issn=1758-8103&title=Clinical+Obesity&atitle=Increased+body+mass+index+is+negatively+associated+with+ovarian+reserve+as+measured+by+anti-Mullerian+hormone+in+patients+with+polycystic+ovarian+syndrome.&volume=14&issue=3&spage=e12638&epage=&date=2024&doi=10.1111%2Fcob.12638&pmid=38156530&sid=OVID:medline
+
+<63>
+Unique Identifier
+ 38729719
+Title
+ Obesity and polycystic ovary syndrome influence on intestinal permeability at fasting, and modify the effect of diverse macronutrients on the gut barrier.
+Source
+ Food Research International. 186:114338, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Martinez-Garcia MA; Quintero-Tobar A; de Lope Quinones S; Insenser M; Fernandez-Duran E; Escobar-Morreale HF; Luque-Ramirez M
+Authors Full Name
+ Martinez-Garcia, M Angeles; Quintero-Tobar, Alejandra; de Lope Quinones, Sara; Insenser, Maria; Fernandez-Duran, Elena; Escobar-Morreale, Hector Francisco; Luque-Ramirez, Manuel.
+Institution
+ Martinez-Garcia, M Angeles. Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain.
+ Quintero-Tobar, Alejandra. Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain.
+ de Lope Quinones, Sara. Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain.
+ Insenser, Maria. Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain.
+ Fernandez-Duran, Elena. Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain.
+ Escobar-Morreale, Hector Francisco. Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain.
+ Luque-Ramirez, Manuel. Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain. Electronic address: manuel.luquer@uah.es.
+MeSH Subject Headings
+ Humans
+ Polycystic Ovary Syndrome/me [Metabolism]
+ *Polycystic Ovary Syndrome
+ Female
+ Adult
+ *Permeability
+ *Obesity
+ Fasting/bl [Blood]
+ *Fasting
+ Male
+ Glucagon-Like Peptide 2/bl [Blood]
+ *Glucagon-Like Peptide 2
+ Intestinal Mucosa/me [Metabolism]
+ Gastrointestinal Microbiome
+ Nutrients
+ Young Adult
+ Haptoglobins/me [Metabolism]
+ Endotoxemia
+ Lipopolysaccharide Receptors/bl [Blood]
+ Acute-Phase Proteins/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Membrane Glycoproteins/bl [Blood]
+ Membrane Glycoproteins/me [Metabolism]
+ Dietary Fats
+ Glucose/me [Metabolism]
+ Intestinal Barrier Function
+ Carrier Proteins
+ Protein Precursors
+Keyword Heading
+ Endotoxemia
+ Hyperandrogenism
+ Intestinal permeability
+ Macronutrients
+ Obesity
+ Postprandial response
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Women with the extremely prevalent polycystic ovary syndromegather multiple cardiovascular risk factors and chronic subclinical inflammation. Interactions between diet, adiposity, and gut microbiota modulate intestinal permeabilityand bacterial product translocation, and may contribute to the chronic inflammation process associated with the polycystic ovary syndrome. In the present study, we aimed to address the effects of obesity, functional hyperandrogenism, and diverse oral macronutrients on intestinal permeabilityby measuring circulating markers of gut barrier dysfunction and endotoxemia. Participants included 17 non-hyperandrogenic control women, 17 women with polycystic ovary syndrome, and 19 men that were submitted to glucose, lipid, and protein oral loads. Lipopolysaccharide-binding protein, plasma soluble CD14, succinate, zonulin family peptide, and glucagon-like peptide-2 were determined at fasting and after oral challenges. Macronutrient challenges induced diverse changes on circulating intestinal permeabilitybiomarkers in the acute postprancial period, with lipids and proteins showing the most unfavorable and favorable effects, respectively. Particularly, lipopolysaccharide-binding protein, zonulin family peptide, and glucagon-like peptide-2 responses were deregulated by the presence of obesity after glucose and lipid challenges. Obese subjects showed higher fasting intestinal permeabilitybiomarkers levels than non-obese individuals, except for plasma soluble CD14. The polycystic ovary syndromeexacerbated the effect of obesity further increasing fasting glucagon-like peptide-2, lipopolysaccharide-binding protein, and succinate concentrations. We observed specific interactions of the polycystic ovary syndromewith obesity in the postprandial response of succinate, zonulin family peptide, and glucagon-like peptide-2. In summary, obesity and polycystic ovary syndromemodify the effect of diverse macronutrients on the gut barrier, and alsoinfluence intestinal permeabilityat fasting,contributing to the morbidity of functional hyperandrogenism by inducing endotoxemia and subclinical chronic inflammation. Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Glucagon-Like Peptide 2). 0 (lipopolysaccharide-binding protein). 0 (Haptoglobins). 0 (Lipopolysaccharide Receptors). 0 (Acute-Phase Proteins). 0 (zonulin). 0 (Biomarkers). 0 (Membrane Glycoproteins). 0 (Dietary Fats). IY9XDZ35W2 (Glucose). 0 (Carrier Proteins). 0 (Protein Precursors).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.foodres.2024.114338
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Martinez-Garcia&issn=0963-9969&title=Food+Research+International&atitle=Obesity+and+polycystic+ovary+syndrome+influence+on+intestinal+permeability+at+fasting%2C+and+modify+the+effect+of+diverse+macronutrients+on+the+gut+barrier.&volume=186&issue=&spage=114338&epage=&date=2024&doi=10.1016%2Fj.foodres.2024.114338&pmid=38729719&sid=OVID:medline
+
+<64>
+Unique Identifier
+ 38131261
+Title
+ Natriuretic peptides, body mass index and heart failure risk: Pooled analyses of SAVOR-TIMI 53, DECLARE-TIMI 58 and CAMELLIA-TIMI 61.
+Source
+ European Journal of Heart Failure. 26(2):260-269, 2024 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Patel SM; Morrow DA; Bellavia A; Berg DD; Bhatt DL; Jarolim P; Leiter LA; McGuire DK; Raz I; Steg PG; Wilding JPH; Sabatine MS; Wiviott SD; Braunwald E; Scirica BM; Bohula EA
+Author NameID
+ Patel, Siddharth M; ORCID: https://orcid.org/0000-0002-4637-4361
+Authors Full Name
+ Patel, Siddharth M; Morrow, David A; Bellavia, Andrea; Berg, David D; Bhatt, Deepak L; Jarolim, Petr; Leiter, Lawrence A; McGuire, Darren K; Raz, Itamar; Steg, P Gabriel; Wilding, John P H; Sabatine, Marc S; Wiviott, Stephen D; Braunwald, Eugene; Scirica, Benjamin M; Bohula, Erin A.
+Institution
+ Patel, Siddharth M. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Morrow, David A. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Bellavia, Andrea. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Berg, David D. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Bhatt, Deepak L. Mount Sinai Heart, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA.
+ Jarolim, Petr. Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Leiter, Lawrence A. Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.
+ McGuire, Darren K. Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
+ McGuire, Darren K. Parkland Health and Hospital System, Dallas, TX, USA.
+ Raz, Itamar. Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
+ Raz, Itamar. Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
+ Steg, P Gabriel. Universite Paris Cite, INSERM U-1148, Hopital Bichat, Assistance Publique-Hopitaux de Paris, Paris, France.
+ Steg, P Gabriel. FACT (French Alliance for Cardiovascular Trials), Paris, France.
+ Wilding, John P H. Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool, UK.
+ Sabatine, Marc S. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Wiviott, Stephen D. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Braunwald, Eugene. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Scirica, Benjamin M. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Bohula, Erin A. TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+MeSH Subject Headings
+ Humans
+ Body Mass Index
+ Biomarkers
+ Heart Failure/ep [Epidemiology]
+ Heart Failure/dt [Drug Therapy]
+ *Heart Failure
+ Natriuretic Peptide, Brain/tu [Therapeutic Use]
+ Benzhydryl Compounds/tu [Therapeutic Use]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Peptide Fragments/tu [Therapeutic Use]
+ Prognosis
+ *Glucosides
+Keyword Heading
+ Biomarkers
+ Clinical trials
+ Heart failure
+ Natriuretic peptides
+ Obesity
+ Risk stratification
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations are lower in patients with obesity. The interaction between body mass index (BMI) and NT-proBNP with respect to heart failure risk remains incompletely defined.
+
+ METHODS AND RESULTS: Data were pooled across three randomized clinical trials enrolling predominantly patients who were overweight or obese with established cardiometabolic disease: SAVOR-TIMI 53, DECLARE-TIMI 58 and CAMELLIA-TIMI 61. Hospitalization for heart failure (HHF) was examined across strata of baseline BMI and NT-proBNP. The effect of dapagliflozin versus placebo was assessed for a treatment interaction across BMI categories in patients with or without an elevated baseline NT-proBNP (>=125 pg/ml). Among 24 455 patients, the median NT-proBNP was 96 (interquartile range [IQR]: 43-225) pg/ml and the median BMI was 33 (IQR 29-37) kg/m2, with 68% of patients having a BMI >=30 kg/m2. There was a significant inverse association between NT-proBNP and BMI which persisted after adjustment for all clinical variables (p < 0.001). Within any range of NT-proBNP, those at higher BMI had higher risk of HHF at 2 years (comparing BMI <30 vs. >=40 kg/m2 for NT-proBNP ranges of <125, 125-<450 and >=450 pg/ml: 0.0% vs. 0.6%, 1.3% vs. 4.0%, and 8.1% vs. 13.8%, respectively), which persisted after multivariable adjustment (adjusted hazard ratio [HRadj] 7.47, 95% confidence interval [CI] 3.16-17.66, HRadj 3.22 [95% CI 2.13-4.86], and HRadj 1.87 [95% CI 1.35-2.60], respectively). In DECLARE-TIMI 58, dapagliflozin versus placebo consistently reduced HHF across BMI categories in those with an elevated NT-proBNP (p-trend for HR across BMI = 0.60), with a pattern of greater absolute risk reduction (ARR) at higher BMI (ARR for BMI <30 to >=40 kg/m2: 2.2% to 4.7%; p-trend = 0.059).
+
+ CONCLUSIONS: The risk of HHF varies across BMI categories for any given range of circulating NT-proBNP. These findings showcase the importance of considering BMI when applying NT-proBNP for heart failure risk stratification, particularly for patients with low-level elevations in NT-proBNP (125-<450 pg/ml) where there appears to be a clinically meaningful absolute and relative risk gradient. Copyright © 2023 European Society of Cardiology.
+Registry Number/Name of Substance
+ 1ULL0QJ8UC (dapagliflozin). 0 (Biomarkers). 114471-18-0 (Natriuretic Peptide, Brain). 0 (Benzhydryl Compounds). 0 (Peptide Fragments). 0 (Glucosides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1002%2fejhf.3118
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Patel&issn=1388-9842&title=European+Journal+of+Heart+Failure&atitle=Natriuretic+peptides%2C+body+mass+index+and+heart+failure+risk%3A+Pooled+analyses+of+SAVOR-TIMI+53%2C+DECLARE-TIMI+58+and+CAMELLIA-TIMI+61.&volume=26&issue=2&spage=260&epage=269&date=2024&doi=10.1002%2Fejhf.3118&pmid=38131261&sid=OVID:medline
+
+<65>
+Unique Identifier
+ 38715070
+Title
+ Association between the triglyceride-glucose index and subclinical left ventricular systolic dysfunction in obese patients.
+Source
+ Cardiovascular Diabetology. 23(1):161, 2024 May 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li GA; Huang J; Wang J; Fan L
+Authors Full Name
+ Li, Guang-An; Huang, Jun; Wang, Jing; Fan, Li.
+Institution
+ Li, Guang-An. Department of Echocardiography, The Affiliated Changzhou Second People's Hospital with Nanjing Medical University, 213003, Changzhou, China.
+ Huang, Jun. Department of Echocardiography, The Affiliated Changzhou Second People's Hospital with Nanjing Medical University, 213003, Changzhou, China. drhuangjun@njmu.edu.cn.
+ Wang, Jing. Department of Weight Loss Metabolic Surgery, The Affiliated Changzhou Second People's Hospital with Nanjing Medical University, 213003, Changzhou, China.
+ Fan, Li. Department of Echocardiography, The Affiliated Changzhou Second People's Hospital with Nanjing Medical University, 213003, Changzhou, China.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ Ventricular Dysfunction, Left/pp [Physiopathology]
+ Ventricular Dysfunction, Left/bl [Blood]
+ Ventricular Dysfunction, Left/dg [Diagnostic Imaging]
+ Ventricular Dysfunction, Left/di [Diagnosis]
+ Ventricular Dysfunction, Left/ep [Epidemiology]
+ *Ventricular Dysfunction, Left
+ Obesity/di [Diagnosis]
+ Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ Obesity/ep [Epidemiology]
+ Obesity/co [Complications]
+ *Obesity
+ Middle Aged
+ Triglycerides/bl [Blood]
+ *Triglycerides
+ *Ventricular Function, Left
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Adult
+ Risk Factors
+ *Asymptomatic Diseases
+ Risk Assessment
+ Systole
+ Aged
+ Cross-Sectional Studies
+ Predictive Value of Tests
+ Retrospective Studies
+Keyword Heading
+ Global longitudinal strain
+ Obese
+ Triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The association between the triglyceride-glucose (TyG) index and subclinical left ventricular (LV) systolic dysfunction in obese patients remains unclear. This study aimed to investigate the relationship between the TyG index and LV global longitudinal strain (GLS) in obese patients.
+
+ METHODS: A total of 1028 obese patients from January 2019 to January 2024 were included in the present study. Clinical parameters and biochemical and echocardiographic data were obtained from the participants. LV GLS was obtained from the GE EchoPAC workstation for evaluating subclinical LV function. The TyG index was calculated as Ln (fasting TG [mg/dL] x fasting glucose [mg/dL]/2). LV GLS was compared between obese patients with a high TyG index and those with a low TyG index.
+
+ RESULTS: Obese patients with a high TyG index had greater incidences of hypertension, diabetes mellitus and hyperlipidaemia. The LV GLS was significantly lower in the high TyG index group than in the low TyG index group (P = 0.01). After adjusting for sex, age, body mass index, heart rate, hypertension, diabetes mellitus, dyslipidaemia, blood urea nitrogen, serum creatinine, LV mass and LV hypertrophy, the TyG index remained an independent risk indicator related to an LV GLS < 20% (OR: 1.520, 95% CI: 1.040 to 2.221; P = 0.031).
+
+ CONCLUSIONS: We concluded that an increase in the TyG index is independently associated with subclinical LV systolic dysfunction in obese patients. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12933-024-02253-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Association+between+the+triglyceride-glucose+index+and+subclinical+left+ventricular+systolic+dysfunction+in+obese+patients.&volume=23&issue=1&spage=161&epage=&date=2024&doi=10.1186%2Fs12933-024-02253-8&pmid=38715070&sid=OVID:medline
+
+<66>
+Unique Identifier
+ 38408536
+Title
+ Biochemical evaluation of possible protective effect of purslane extract in experimentally induced arthritis associated with obesity.
+Source
+ Prostaglandins & Other Lipid Mediators. 172:106823, 2024 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elharrif MG; Abdel Maksoud HA; Abdullah MH; Abd Elmohsen AS
+Authors Full Name
+ Elharrif, Mohamed G; Abdel Maksoud, H A; Abdullah, M H; Abd Elmohsen, Alaa S.
+Institution
+ Elharrif, Mohamed G. Department of Basic Medical Sciences, Shaqra University, Kingdom of Saudi Arabia. Electronic address: al_harrif@yahoo.com.
+ Abdel Maksoud, H A. Department of Biochemistry, Benha University. Egypt.
+ Abdullah, M H. Department of Biochemistry, October 6th University. Egypt.
+ Abd Elmohsen, Alaa S. Department of Biochemistry, Benha University. Egypt.
+MeSH Subject Headings
+ Animals
+ Obesity/me [Metabolism]
+ Obesity/dt [Drug Therapy]
+ *Obesity
+ Male
+ Rats
+ Arthritis, Experimental/dt [Drug Therapy]
+ Arthritis, Experimental/me [Metabolism]
+ Arthritis, Experimental/pc [Prevention & Control]
+ *Arthritis, Experimental
+ Plant Extracts/pd [Pharmacology]
+ *Plant Extracts
+ Biomarkers/bl [Blood]
+ Diet, High-Fat/ae [Adverse Effects]
+ C-Reactive Protein/me [Metabolism]
+Keyword Heading
+ Arthritis
+ Lipid Profile
+ Obesity
+ Purslane Extract
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Arthritis, a prevalent inflammatory condition, is often linked to obesity as a contributing factor. This study aimed to assess the potential protective effects of purslane extract in male albino rats with induced arthritis and obesity. Fifty rats were randomly assigned to five groups: a control group, an induced arthritis-high-fat diet group, a high-dose purslane extract-supplemented group (300mg/kg body weight) for 8 weeks, a low-dose purslane extract-supplemented group (150mg/kg body weight) for 8 weeks, and a metformin-supplemented group. Arthritis was induced in the rats using Complete Freund's Adjuvant. Plasma biomarkers, including Total Cholesterol, Triglycerides, HDL-cholesterol, LDL-cholesterol, C Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR), Rheumatoid Factor (RF), and Anti-CCP, were assessed in each group. The results revealed a significant improvement in these biomarkers in the high-dose purslane-supplemented group (300mg/kg body weight) compared to the induced arthritis-high-fat-diet group. This suggests a potential protective role of purslane against arthritis associated with obesity, likely attributed to its lipolytic capacity and anti-inflammatory properties. These findings contribute to our understanding of the interplay between obesity, arthritis, and natural interventions, providing valuable insights for future therapeutic approaches. Copyright © 2024 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Plant Extracts). 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.prostaglandins.2024.106823
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elharrif&issn=1098-8823&title=Prostaglandins+%26+Other+Lipid+Mediators&atitle=Biochemical+evaluation+of+possible+protective+effect+of+purslane+extract+in+experimentally+induced+arthritis+associated+with+obesity.&volume=172&issue=&spage=106823&epage=&date=2024&doi=10.1016%2Fj.prostaglandins.2024.106823&pmid=38408536&sid=OVID:medline
+
+<67>
+Unique Identifier
+ 37592776
+Title
+ Study of the Relationship Between Insulin Resistance, Iron Status Markers, and Body Weight in a Sample of Egyptian Population.
+Source
+ Current Diabetes Reviews. 20(4):e170823219896, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bahaaeldin AM; Hussein MS; Hashem SS; Saleh AMM
+Authors Full Name
+ Bahaaeldin, Ahmed Mohamed; Hussein, Magda Shoukry; Hashem, Shaimaa Shaaban; Saleh, Amr Mahmoud Mohamed.
+Institution
+ Bahaaeldin, Ahmed Mohamed. Internal Medicine and Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
+ Hussein, Magda Shoukry. Internal Medicine and Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
+ Hashem, Shaimaa Shaaban. Internal Medicine and Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
+ Saleh, Amr Mahmoud Mohamed. Internal Medicine and Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
+MeSH Subject Headings
+ Humans
+ *Insulin Resistance
+ Egypt/ep [Epidemiology]
+ Adult
+ Middle Aged
+ Male
+ Female
+ Case-Control Studies
+ Iron/bl [Blood]
+ *Iron
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Adolescent
+ Young Adult
+ Aged
+ *Body Weight
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Blood Glucose/an [Analysis]
+ Blood Glucose/me [Metabolism]
+Keyword Heading
+ Insulin resistance
+ T2DM
+ body weight
+ iron status markers
+ metabolic syndrome.
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Iron plays a key role in the regulation of body iron homeostasis and is used as a clinical marker for iron deficiency (ID) and hemochromatosis. The idea that iron dysregulation may contribute to various metabolic diseases, such as obesity, insulin resistance, MetS, and T2DM, is a hot topic of discussion.
+
+ AIM: The aim of this study is to investigate the relationship insulin resistance, iron status markers, and body weight in a sample of Egyptian population.
+
+ METHODS: A case control study was conducted on 90 subjects with age ranging from 18 to 70 years old from a diabetes outpatient clinic, and they were divided to three groups: Group I, non-obese- non-diabetic as the control group; Group II, obese-non-diabetic; and Group III, obese-diabetic.
+
+ RESULTS: In our study, there was no statistically significant difference between the three studied groups regarding the different iron parameters. Similarly, we found that neither HOMA-IR nor body weight had a significant correlation with iron status markers. On the contrary, we detected significant positive correlations between the TIBC and the fasting blood glucose, between the serum iron and the LDL, between the TSAT and the systolic blood pressure, and between the HOMA-IR and hematocrit.
+
+ CONCLUSION: Our study demonstrated no direct statistical significant relationship between the different iron parameters, obesity, and insulin resistance, either in the diabetic or non-diabetic subjects. This may be due to the complex metabolic dysregulation and the small number of the sample for future investigations. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ E1UOL152H7 (Iron). 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.2174%2f1573399820666230817102053
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bahaaeldin&issn=1573-3998&title=Current+Diabetes+Reviews&atitle=Study+of+the+Relationship+Between+Insulin+Resistance%2C+Iron+Status+Markers%2C+and+Body+Weight+in+a+Sample+of+Egyptian+Population.&volume=20&issue=4&spage=e170823219896&epage=&date=2024&doi=10.2174%2F1573399820666230817102053&pmid=37592776&sid=OVID:medline
+
+<68>
+Unique Identifier
+ 38711986
+Title
+ Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait.
+Source
+ Frontiers in Endocrinology. 15:1392675, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alramah T; Cherian P; Al-Khairi I; Abu-Farha M; Thanaraj TA; Albatineh AN; Safadi F; Ali H; Abdul-Ghani M; Tuomilehto J; Koistinen HA; Al-Mulla F; Abubaker J
+Authors Full Name
+ Alramah, Tahani; Cherian, Preethi; Al-Khairi, Irina; Abu-Farha, Mohamed; Thanaraj, Thangavel Alphonse; Albatineh, Ahmed N; Safadi, Fayez; Ali, Hamad; Abdul-Ghani, Muhammad; Tuomilehto, Jaakko; Koistinen, Heikki A; Al-Mulla, Fahd; Abubaker, Jehad.
+Institution
+ Alramah, Tahani. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.
+ Cherian, Preethi. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.
+ Al-Khairi, Irina. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.
+ Abu-Farha, Mohamed. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.
+ Abu-Farha, Mohamed. Department of Translational Research, Dasman Diabetes Institute, Dasman, Kuwait.
+ Thanaraj, Thangavel Alphonse. Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman, Kuwait.
+ Albatineh, Ahmed N. Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
+ Safadi, Fayez. Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, United States.
+ Safadi, Fayez. Rebecca D. Considine Research Institute, Akron Children Hospital, Akron, OH, United States.
+ Ali, Hamad. Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Health Sciences Center, Kuwait University, Jabriya, Kuwait.
+ Abdul-Ghani, Muhammad. Department of Translational Research, Dasman Diabetes Institute, Dasman, Kuwait.
+ Abdul-Ghani, Muhammad. Division of Diabetes, University of Texas Health Science Center, San Antonio, TX, United States.
+ Tuomilehto, Jaakko. Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
+ Tuomilehto, Jaakko. Department of Public Health, University of Helsinki, Helsinki, Finland.
+ Tuomilehto, Jaakko. Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Koistinen, Heikki A. Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
+ Koistinen, Heikki A. Internal Medicine and Endocrinology, Minerva Foundation Institute for Medical Research, Helsinki, Finland.
+ Koistinen, Heikki A. Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Al-Mulla, Fahd. Department of Translational Research, Dasman Diabetes Institute, Dasman, Kuwait.
+ Al-Mulla, Fahd. Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman, Kuwait.
+ Abubaker, Jehad. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman, Kuwait.
+MeSH Subject Headings
+ Humans
+ Male
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/eh [Ethnology]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Female
+ Kuwait/ep [Epidemiology]
+ Middle Aged
+ Cross-Sectional Studies
+ Obesity/bl [Blood]
+ Obesity/eh [Ethnology]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Adaptor Proteins, Signal Transducing/bl [Blood]
+ *Adaptor Proteins, Signal Transducing
+ Genetic Markers
+ Adult
+ Aged
+ Ethnicity
+ Biomarkers/bl [Blood]
+ Bone Morphogenetic Proteins/bl [Blood]
+Keyword Heading
+ SOST
+ T2DM
+ bone metabolism
+ ethnicity
+ gender
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and Type 2 Diabetes Mellitus (T2DM) are intricate metabolic disorders with a multifactorial etiology, often leading to a spectrum of complications. Recent research has highlighted the impact of these conditions on bone health, with a particular focus on the role of sclerostin (SOST), a protein molecule integral to bone metabolism. Elevated circulating levels of SOST have been observed in patients with T2DM compared to healthy individuals. This study aims to examine the circulating levels of SOST in a multiethnic population living in Kuwait and to elucidate the relationship between SOST levels, obesity, T2DM, and ethnic background. The study is a cross-sectional analysis of a large cohort of 2083 individuals living in Kuwait. The plasma level of SOST was measured using a bone panel multiplex assay. The study found a significant increase in SOST levels in individuals with T2DM (1008.3 pg/mL, IQR-648) compared to non-diabetic individuals (710.6 pg/mL, IQR-479). There was a significant gender difference in median SOST levels, with males exhibiting higher levels than females across various covariates (diabetes, IR, age, weight, and ethnicity). Notably, SOST levels varied significantly with ethnicity: Arabs (677.4 pg/mL, IQR-481.7), South Asians (914.6 pg/mL, IQR-515), and Southeast Asians (695.2 pg/mL, IQR-436.8). Furthermore, SOST levels showed a significant positive correlation with gender, age, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, HbA1c, insulin, total cholesterol, triglycerides, HDL, LDL, ALT, and AST (p-Value >=0.05). South Asian participants, who exhibited the highest SOST levels, demonstrated the most pronounced associations, even after adjusting for age, gender, BMI, and diabetes status (p-Value >=0.05). The observed correlations of SOST with various clinical parameters suggest its significant role in the diabetic milieu, particularly pronounced in the South Asian population compared to other ethnic groups. Copyright © 2024 Alramah, Cherian, Al-Khairi, Abu-Farha, Thanaraj, Albatineh, Safadi, Ali, Abdul-Ghani, Tuomilehto, Koistinen, Al-Mulla and Abubaker.
+Registry Number/Name of Substance
+ 0 (SOST protein, human). 0 (Adaptor Proteins, Signal Transducing). 0 (Genetic Markers). 0 (Biomarkers). 0 (Bone Morphogenetic Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3389%2ffendo.2024.1392675
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alramah&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Evaluating+the+correlation+of+sclerostin+levels+with+obesity+and+type+2+diabetes+in+a+multiethnic+population+living+in+Kuwait.&volume=15&issue=&spage=1392675&epage=&date=2024&doi=10.3389%2Ffendo.2024.1392675&pmid=38711986&sid=OVID:medline
+
+<69>
+Unique Identifier
+ 38581628
+Title
+ Short-Term Changes in Weight, Body Composition, and Metabolic Biomarkers After Laparoscopic Sleeve Gastrectomy in Patients with Obesity: A Comparative Prospective Study.
+Source
+ Obesity Surgery. 34(5):1801-1809, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hong W; Tang W; Hao X; Tao C; Yin P; Jin Y; Zhou Y
+Author NameID
+ Zhou, Yunfeng; ORCID: http://orcid.org/0000-0001-5260-3071
+Authors Full Name
+ Hong, Wei; Tang, Wenjuan; Hao, Xiaojun; Tao, Chao; Yin, Pengzhan; Jin, Yan; Zhou, Yunfeng.
+Institution
+ Hong, Wei. Department of Radiology, the First Affiliated Hospital of Wannan Medical College, No.2 Zheshan West St., Wuhu, 241000, China.
+ Tang, Wenjuan. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
+ Hao, Xiaojun. Department of Radiology, the First Affiliated Hospital of Wannan Medical College, No.2 Zheshan West St., Wuhu, 241000, China.
+ Tao, Chao. Department of Radiology, the First Affiliated Hospital of Wannan Medical College, No.2 Zheshan West St., Wuhu, 241000, China.
+ Yin, Pengzhan. Department of Radiology, the First Affiliated Hospital of Wannan Medical College, No.2 Zheshan West St., Wuhu, 241000, China.
+ Jin, Yan. Department of Gastrointestinal Surgery, the First Affiliated Hospital of Wannan Medical College, Wuhu, 241000, China.
+ Zhou, Yunfeng. Department of Radiology, the First Affiliated Hospital of Wannan Medical College, No.2 Zheshan West St., Wuhu, 241000, China. zhouyunfeng808@163.com.
+MeSH Subject Headings
+ Humans
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+ Prospective Studies
+ Longitudinal Studies
+ Retrospective Studies
+ Obesity/su [Surgery]
+ Metabolic Syndrome/su [Surgery]
+ *Metabolic Syndrome
+ Body Composition
+ Gastrectomy
+ *Laparoscopy
+ Biomarkers/me [Metabolism]
+ Treatment Outcome
+Keyword Heading
+ Body composition
+ CT
+ Laparoscopic sleeve gastrectomy
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: To investigate the changes in weight, body composition, and metabolic biomarkers in patients with obesity after laparoscopic sleeve gastrectomy (LSG) and compare those changes between patients with and without metabolic syndrome (MS).
+
+ MATERIALS AND METHODS: This retrospective longitudinal study included 76 patients who underwent LSG, among whom 32 had complete 1-year postoperative body composition and metabolic biomarkers. Body composition was measured by quantitative CT. Weight changes were compared between the MS and non-MS groups at 1-, 3-, 6-, and 12-month post-LSG in all patients; changes in body compositions and metabolic biomarkers from one day pre-LSG to 12-month post-LSG were also compared in those 32 patients.
+
+ RESULTS: MS occurred in 46% (35/76) of all patients and 44% (14/32) of patients with complete follow-up data. Excess weight loss was lower in the MS group than that in the non-MS group at 1-, 3-, 6-, and 12-month post-LSG; the 12-month difference was significant (MS vs. non-MS: 0.91 +/- 0.22 vs. 1.07 +/- 0.42, P = 0.04). The greatest rate of visceral fat area (VFA) change occurred 12-month post-LSG in both the non-MS [0.62(0.55,0.7)] and MS [0.6(0.51,0.63)] groups. The most significant reduction in ectopic fat occurred in liver fat (LF) [non-MS, 0.45(0.22,0.58); MS, 0.39(0.23,0.58)].
+
+ CONCLUSION: LGS significantly improves weight, body composition, and metabolic biomarkers in populations with obesity, regardless of whether they have MS. Among the body composition, VFA and LF were the most significantly improved body composition measurements. Copyright © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs11695-024-07208-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hong&issn=0960-8923&title=Obesity+Surgery&atitle=Short-Term+Changes+in+Weight%2C+Body+Composition%2C+and+Metabolic+Biomarkers+After+Laparoscopic+Sleeve+Gastrectomy+in+Patients+with+Obesity%3A+A+Comparative+Prospective+Study.&volume=34&issue=5&spage=1801&epage=1809&date=2024&doi=10.1007%2Fs11695-024-07208-2&pmid=38581628&sid=OVID:medline
+
+<70>
+Unique Identifier
+ 37924474
+Title
+ Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity.
+Source
+ Journal of Endocrinological Investigation. 47(5):1289-1294, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Matias I; Lehmann EW; Zizzari P; Byberg S; Cota D; Torekov SS; Quarta C
+Author NameID
+ Quarta, C; ORCID: http://orcid.org/0000-0002-1352-4239
+Authors Full Name
+ Matias, I; Lehmann, E W; Zizzari, P; Byberg, S; Cota, D; Torekov, S S; Quarta, C.
+Institution
+ Matias, I. University of Bordeaux, INSERM, Neurocentre Magendie, U1215, 33000, Bordeaux, France.
+ Lehmann, E W. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.
+ Zizzari, P. University of Bordeaux, INSERM, Neurocentre Magendie, U1215, 33000, Bordeaux, France.
+ Byberg, S. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.
+ Cota, D. University of Bordeaux, INSERM, Neurocentre Magendie, U1215, 33000, Bordeaux, France.
+ Torekov, S S. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark. torekov@sund.ku.dk.
+ Quarta, C. University of Bordeaux, INSERM, Neurocentre Magendie, U1215, 33000, Bordeaux, France. carmelo.quarta@inserm.fr.
+ Quarta, C. INSERM U1215, Neurocentre Magendie, 146 Rue Leo Saignat, 33077, Bordeaux Cedex, France. carmelo.quarta@inserm.fr.
+MeSH Subject Headings
+ Humans
+ Endocannabinoids/bl [Blood]
+ *Endocannabinoids
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ *Obesity
+ Liraglutide/tu [Therapeutic Use]
+ Liraglutide/pd [Pharmacology]
+ *Liraglutide
+ Male
+ Female
+ Glucagon-Like Peptide-1 Receptor/ag [Agonists]
+ Glucagon-Like Peptide-1 Receptor/me [Metabolism]
+ *Glucagon-Like Peptide-1 Receptor
+ Middle Aged
+ Adult
+ Ethanolamines/tu [Therapeutic Use]
+ *Ethanolamines
+ Weight Loss/de [Drug Effects]
+ Oleic Acids
+ Polyunsaturated Alkamides
+ Biomarkers/bl [Blood]
+ Arachidonic Acids/bl [Blood]
+ Amides/tu [Therapeutic Use]
+ Amides/pd [Pharmacology]
+ Palmitic Acids
+Keyword Heading
+ Endocannabinoid-related molecules
+ Endocannabinoids
+ GLP-1R agonist
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: N-acylethanolamines (NAEs) include endocannabinoid (EC) and EC-related molecules that impact the anti-obesity and anti-diabetic efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RA) in animal studies. However, the clinical relevance of these findings remains to be determined. Here, we tested whether GLP-1RA treatment affects circulating NAE levels and whether NAEs may predict the efficacy of GLP-1RA treatment in humans with obesity undergoing weight loss maintenance.
+
+ MATERIALS AND METHODS: We profiled plasma levels of NAEs in participants with obesity undergoing weight loss maintenance with (n = 23)/or without (n = 20) treatment with the GLP-1RA liraglutide. NAE levels were measured at three different time points: before the start of the study, at the end of the diet-induced weight loss, and after 52-weeks treatment. Linear regression analyses were used to investigate whether pharmacological responses could be predicted by NAEs levels.
+
+ RESULTS: Liraglutide treatment reduced plasma concentrations of the NAE and oleoyl-ethanolamide (OEA), without altering arachidonoyl-ethanolamide (AEA) levels and palmitoyl-ethanolamide (PEA) levels. High pre-treatment levels of OEA were predictive of superior compound-mediated effects on fasting insulin and triglyceride levels. High pre-treatment PEA and AEA levels were also predictive of superior Liraglutide-mediated effects on triglyceride levels.
+
+ CONCLUSIONS: Our data suggests that specific NAEs such as OEA and AEA are promising biomarkers of GLP-1RA metabolic efficacy in humans with obesity during weight loss maintenance. Plasma profiling of EC-related molecules may be a promising strategy to tailor GLP-1R-based therapies to individual needs in obesity and diabetes management. Copyright © 2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).
+Registry Number/Name of Substance
+ 0 (Endocannabinoids). 839I73S42A (Liraglutide). 0 (Glucagon-Like Peptide-1 Receptor). 0 (Ethanolamines). 1HI5J9N8E6 (oleoylethanolamide). 0 (Oleic Acids). 0 (Polyunsaturated Alkamides). 0 (Biomarkers). 0 (N-acylethanolamines). UR5G69TJKH (anandamide). 6R8T1UDM3V (palmidrol). 0 (Arachidonic Acids). 0 (Amides). 0 (Palmitic Acids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs40618-023-02228-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Matias&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Endocannabinoid-related+molecules+predict+the+metabolic+efficacy+of+GLP-1+receptor+agonism+in+humans+with+obesity.&volume=47&issue=5&spage=1289&epage=1294&date=2024&doi=10.1007%2Fs40618-023-02228-8&pmid=37924474&sid=OVID:medline
+
+<71>
+Unique Identifier
+ 38646988
+Title
+ Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity.
+Source
+ Endokrynologia Polska. 75(2):183-191, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ellidag HY; Aslankoc R; Kok M; Aykal G; Aydin O; Ozmen O; Cakir RC; Dogan U
+Author NameID
+ Ellidag, Hamit Yasar; ORCID: https://orcid.org/0000-0002-7511-2547
+ Aslankoc, Rahime; ORCID: https://orcid.org/0000-0001-9516-08
+ Kok, Mehmet; ORCID: https://orcid.org/0000-0002-5285-4513
+ Aykal, Guzin; ORCID: https://orcid.org/0000-0002-2413-2695
+ Aydin, Ozgur; ORCID: https://orcid.org/0000-0002-6123-6186
+ Ozmen, Ozlem; ORCID: https://orcid.org/0000-0002-1835-1082
+ Cakir, Remzi Can; ORCID: https://orcid.org/0000-0002-6151-3534
+ Dogan, Ugur; ORCID: https://orcid.org/0000-0001-8097-3168
+Authors Full Name
+ Ellidag, Hamit Yasar; Aslankoc, Rahime; Kok, Mehmet; Aykal, Guzin; Aydin, Ozgur; Ozmen, Ozlem; Cakir, Remzi Can; Dogan, Ugur.
+Institution
+ Ellidag, Hamit Yasar. Department of Clinical Biochemistry, Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkiye. hayael1980@hotmail.com.
+ Aslankoc, Rahime. Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkiye.
+ Kok, Mehmet. Department of Internal Medicine, Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkiye.
+ Aykal, Guzin. Department of Clinical Biochemistry, Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkiye.
+ Aydin, Ozgur. Department of Clinical Biochemistry, Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkiye.
+ Ozmen, Ozlem. Department of Pathology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkiye.
+ Cakir, Remzi Can. Department of General Surgery Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkiye.
+ Dogan, Ugur. Department of General Surgery Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkiye.
+MeSH Subject Headings
+ Testosterone/bl [Blood]
+ *Testosterone
+ *Oxidative Stress
+ Male
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2
+ Animals
+ Obesity/bl [Blood]
+ *Obesity
+ Rats
+ Diabetes Mellitus, Type 1/bl [Blood]
+ *Diabetes Mellitus, Type 1
+ *Rats, Sprague-Dawley
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus, Experimental/bl [Blood]
+ Diabetes Mellitus, Experimental/me [Metabolism]
+Keyword Heading
+ free radicals
+ obesity
+ oxidative stress
+ testosterone
+ type 1 diabetes mellitus
+ type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity, type 1 diabetes mellitus (T1DM), and type 2 diabetes mellitus (T2DM) are metabolic diseases that continue to be a global problem. Testosterone levels in men are affected by several factors, including obesity and DM. Although the relationship between diabetes and testosterone is not fully understood, oxidative stress is thought to play a major role. The aim of this study was to compare serum testosterone levels and oxidative stress markers [total antioxidant status (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), and ischaemic modified albumin (IMA)] among the control group and experimentally induced obese, T1DM, and T2DM rats.
+
+ MATERIAL AND METHODS: The study included 28 male Sprague-Dawley rats divided into 4 groups: the obesity group were fed a high-fat diet (HFD), the T2DM group received a HFD plus a single dose of streptozocin (STZ), the T1DM group received only STZ, and there was a control group. Serum testosterone, TAS, TOS, OSI, and IMA were analysed.
+
+ RESULTS: Serum testosterone levels were lower in the T1DM and T2DM groups compared to the control and obesity groups. The TOS levels were highest in the T2DM group, followed by the T1DM group, the obesity group, and finally the control group. No significant difference was found between the obesity group and the control group in terms of TOS levels. Regarding TAS levels, the order observed was control group > obesity group > T2DM > T1DM. Testosterone was positively correlated with TAS and negatively correlated with TOS and OSI.
+
+ CONCLUSIONS: Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.
+Registry Number/Name of Substance
+ 3XMK78S47O (Testosterone). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.5603%2fep.98190
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ellidag&issn=0423-104X&title=Endokrynologia+Polska&atitle=Serum+testosterone+levels+and+oxidative+stress+in+type+1+diabetes%2C+type+2+diabetes%2C+and+obesity.&volume=75&issue=2&spage=183&epage=191&date=2024&doi=10.5603%2Fep.98190&pmid=38646988&sid=OVID:medline
+
+<72>
+Unique Identifier
+ 38342069
+Title
+ Serum iron concentration and leptin inversely relate, partially mediated by body mass index in American adults.
+Source
+ Nutrition Research. 124:1-12, 2024 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen M; Chen Y; Li C
+Authors Full Name
+ Chen, Mi; Chen, Yuebai; Li, Chao.
+Institution
+ Chen, Mi. Division of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China; Department of Physical Medicine and Rehabilitation, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.
+ Chen, Yuebai. Faculty of Science, McGill University, Montreal, Quebec, Canada.
+ Li, Chao. Department of Respiration, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. Electronic address: 208101036@csu.edu.cn.
+MeSH Subject Headings
+ Humans
+ Leptin/bl [Blood]
+ *Leptin
+ *Body Mass Index
+ Male
+ Female
+ Iron/bl [Blood]
+ *Iron
+ Cross-Sectional Studies
+ Adult
+ Middle Aged
+ *Nutrition Surveys
+ United States
+ Obesity/bl [Blood]
+ *Obesity
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Transferrin/me [Metabolism]
+ Transferrin/an [Analysis]
+ Ferritins/bl [Blood]
+ Aged
+Keyword Heading
+ Body mass index
+ Leptin
+ Mediating effect
+ NHANES III
+ Serum iron
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Iron metabolism and leptin are interconnected, and both link with obesity. In this cross-sectional study, we hypothesized that serum iron markers associate with leptin, with body mass index (BMI) acting as a mediator, confounder, and effect modifier in this relationship. We analyzed data from the National Health and Nutrition Examination Survey III, with a focus on serum iron markers and leptin. The relationship between serum iron markers and leptin was determined by multiple linear regression. The bootstrap method was used to investigate the mediating effect of BMI on this association. Among 3888 American adults, serum iron and transferrin saturation showed a negative association with leptin (log2-transformed) (beta: -0.010, 95% confidence interval [CI], -0.013 to -0.006, P < .001; beta: -0.006, 95% CI, -0.008 to -0.004, P < .001). Total iron-binding capacity was positively associated with the serum concentration of leptin (log2-transformed) (beta: 0.002, 95% CI, 0-0.004, P = .0292). Sex, BMI, and body fat percentage significantly influenced these associations. Notably, the association between the iron markers and leptin diminished in individuals with a BMI >=30 kg/m2. There was no observable relationship between leptin and serum ferritin concentrations. BMI mediated 4.81% of the serum iron-leptin association, with no mediation of body fat percentage. Our study identified a link between serum iron and leptin, with BMI as a mediating factor. In clinical settings, it is vital to understand how treatments targeting iron metabolism can directly impact serum leptin concentration and the subsequent physiological changes. Copyright © 2024 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Leptin). E1UOL152H7 (Iron). 0 (Biomarkers). 0 (Transferrin). 9007-73-2 (Ferritins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.nutres.2024.01.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=0271-5317&title=Nutrition+Research&atitle=Serum+iron+concentration+and+leptin+inversely+relate%2C+partially+mediated+by+body+mass+index+in+American+adults.&volume=124&issue=&spage=1&epage=12&date=2024&doi=10.1016%2Fj.nutres.2024.01.009&pmid=38342069&sid=OVID:medline
+
+<73>
+Unique Identifier
+ 38662716
+Title
+ miR-21, miR-221, miR-29 and miR-34 are distinguishable molecular features of a metabolically unhealthy phenotype in young adults.
+Source
+ PLoS ONE [Electronic Resource]. 19(4):e0300420, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mendez-Mancilla A; Turijan-Espinoza E; Vega-Cardenas M; Hernandez-Hernandez GE; Uresti-Rivera EE; Vargas-Morales JM; Portales-Perez DP
+Author NameID
+ Portales-Perez, Diana P; ORCID: https://orcid.org/0000-0001-8063-7869
+Authors Full Name
+ Mendez-Mancilla, Alejandro; Turijan-Espinoza, Eneida; Vega-Cardenas, Mariela; Hernandez-Hernandez, Gloria Estela; Uresti-Rivera, Edith Elena; Vargas-Morales, Juan M; Portales-Perez, Diana P.
+Institution
+ Mendez-Mancilla, Alejandro. Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Mendez-Mancilla, Alejandro. Translational and Molecular Medicine Department, Research Center for Health Sciences and Biomedicine (CICSaB), Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Turijan-Espinoza, Eneida. Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Turijan-Espinoza, Eneida. Translational and Molecular Medicine Department, Research Center for Health Sciences and Biomedicine (CICSaB), Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Vega-Cardenas, Mariela. Translational and Molecular Medicine Department, Research Center for Health Sciences and Biomedicine (CICSaB), Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Hernandez-Hernandez, Gloria Estela. Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Uresti-Rivera, Edith Elena. Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Uresti-Rivera, Edith Elena. Translational and Molecular Medicine Department, Research Center for Health Sciences and Biomedicine (CICSaB), Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Vargas-Morales, Juan M. Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Vargas-Morales, Juan M. Laboratory of Clinical Analysis, Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Portales-Perez, Diana P. Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+ Portales-Perez, Diana P. Translational and Molecular Medicine Department, Research Center for Health Sciences and Biomedicine (CICSaB), Autonomous University of San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.
+MeSH Subject Headings
+ Female
+ Humans
+ Male
+ Young Adult
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Leptin/bl [Blood]
+ Leptin/ge [Genetics]
+ Leptin/me [Metabolism]
+ Metabolic Syndrome/ge [Genetics]
+ Metabolic Syndrome/me [Metabolism]
+ MicroRNAs/ge [Genetics]
+ MicroRNAs/bl [Blood]
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Phenotype
+ Sirtuin 1/ge [Genetics]
+ Sirtuin 1/me [Metabolism]
+Abstract
+ Discrepancies between the measurement of body mass index (BMI) and metabolic health status have been described for the onset of metabolic diseases. Studying novel biomarkers, some of which are associated with metabolic syndrome, can help us to understand the differences between metabolic health (MetH) and BMI. A group of 1469 young adults with pre-specified anthropometric and blood biochemical parameters were selected. Of these, 80 subjects were included in the downstream analysis that considered their BMI and MetH parameters for selection as follows: norm weight metabolically healthy (MHNW) or metabolically unhealthy (MUNW); overweight/obese metabolically healthy (MHOW) or metabolically unhealthy (MUOW). Our results showed for the first time the differences when the MetH status and the BMI are considered as global MetH statures. First, all the evaluated miRNAs presented a higher expression in the metabolically unhealthy group than the metabolically healthy group. The higher levels of leptin, IL-1b, IL-8, IL-17A, miR-221, miR-21, and miR-29 are directly associated with metabolic unhealthy and OW/OB phenotypes (MUOW group). In contrast, high levels of miR34 were detected only in the MUNW group. We found differences in the SIRT1-PGC1alpha pathway with increased levels of SIRT1+ cells and diminished mRNA levels of PGCa in the metabolically unhealthy compared to metabolically healthy subjects. Our results demonstrate that even when metabolic diseases are not apparent in young adult populations, MetH and BMI have a distinguishable phenotype print that signals the potential to develop major metabolic diseases. Copyright: © 2024 Mendez-Mancilla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). 0 (MicroRNAs). 0 (MIRN21 microRNA, human). 0 (MIRN221 microRNA, human). 0 (MIRN29a microRNA, human). 0 (MIRN34 microRNA, human). EC 3-5-1 (SIRT1 protein, human). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1371%2fjournal.pone.0300420
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mendez-Mancilla&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=miR-21%2C+miR-221%2C+miR-29+and+miR-34+are+distinguishable+molecular+features+of+a+metabolically+unhealthy+phenotype+in+young+adults.&volume=19&issue=4&spage=e0300420&epage=&date=2024&doi=10.1371%2Fjournal.pone.0300420&pmid=38662716&sid=OVID:medline
+
+<74>
+Unique Identifier
+ 38126596
+Title
+ Extracellular vesicle microRNA signatures as novel biomarkers in obese asthmatics.
+Source
+ Allergy. 79(5):1398-1400, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sundar IK; Prasad C; Duraisamy SK
+Author NameID
+ Sundar, Isaac Kirubakaran; ORCID: https://orcid.org/0000-0001-6742-3460
+Authors Full Name
+ Sundar, Isaac Kirubakaran; Prasad, Chandrashekar; Duraisamy, Santhosh Kumar.
+Institution
+ Sundar, Isaac Kirubakaran. Department of Internal Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
+ Prasad, Chandrashekar. Department of Internal Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
+ Duraisamy, Santhosh Kumar. Department of Internal Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
+MeSH Subject Headings
+ Humans
+ Extracellular Vesicles/me [Metabolism]
+ *Extracellular Vesicles
+ Asthma/di [Diagnosis]
+ Asthma/ge [Genetics]
+ *Asthma
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ *Biomarkers
+ Obesity/co [Complications]
+ *Obesity
+ Male
+ Female
+Registry Number/Name of Substance
+ 0 (MicroRNAs). 0 (Biomarkers).
+Publication Type
+ Letter. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fall.15979
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sundar&issn=0105-4538&title=Allergy&atitle=Extracellular+vesicle+microRNA+signatures+as+novel+biomarkers+in+obese+asthmatics.&volume=79&issue=5&spage=1398&epage=1400&date=2024&doi=10.1111%2Fall.15979&pmid=38126596&sid=OVID:medline
+
+<75>
+Unique Identifier
+ 38685051
+Title
+ Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus.
+Source
+ Cardiovascular Diabetology. 23(1):146, 2024 Apr 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Grannes H; Ueland T; Simeone P; Liani R; Guagnano MT; Aukrust P; Michelsen AE; Birkeland K; di Castelnuovo A; Cipollone F; Consoli A; Halvorsen B; Gregersen I; Santilli F
+Authors Full Name
+ Grannes, Helene; Ueland, Thor; Simeone, Paola; Liani, Rossella; Guagnano, Maria Teresa; Aukrust, Pal; Michelsen, Annika E; Birkeland, Kare; di Castelnuovo, Augusto; Cipollone, Francesco; Consoli, Agostino; Halvorsen, Bente; Gregersen, Ida; Santilli, Francesca.
+Institution
+ Grannes, Helene. Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.
+ Grannes, Helene. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
+ Ueland, Thor. Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.
+ Ueland, Thor. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
+ Ueland, Thor. Thrombosis Research and Expertise Centre, University of Tromso, Tromso, Norway.
+ Simeone, Paola. Department of Medicine and Aging, and Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
+ Liani, Rossella. Department of Medicine and Aging, and Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
+ Guagnano, Maria Teresa. Department of Medicine and Aging, and Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
+ Aukrust, Pal. Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.
+ Aukrust, Pal. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
+ Aukrust, Pal. Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway.
+ Michelsen, Annika E. Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.
+ Michelsen, Annika E. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
+ Birkeland, Kare. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
+ Birkeland, Kare. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
+ di Castelnuovo, Augusto. Mediterranea Cardiocentro, Naples, Italy.
+ Cipollone, Francesco. Department of Medicine and Aging, and Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
+ Consoli, Agostino. Department of Medicine and Aging, and Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
+ Halvorsen, Bente. Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.
+ Halvorsen, Bente. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
+ Gregersen, Ida. Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway. Ida.gregersen@medisin.uio.no.
+ Santilli, Francesca. Department of Medicine and Aging, and Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy. fra.santilli22@gmail.com.
+MeSH Subject Headings
+ Humans
+ Liraglutide/tu [Therapeutic Use]
+ Liraglutide/ae [Adverse Effects]
+ *Liraglutide
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/th [Therapy]
+ *Diabetes Mellitus, Type 2
+ Weight Loss/de [Drug Effects]
+ *Weight Loss
+ Male
+ Middle Aged
+ Female
+ Obesity/di [Diagnosis]
+ Obesity/bl [Blood]
+ Obesity/th [Therapy]
+ *Obesity
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Antigens, Differentiation, Myelomonocytic/bl [Blood]
+ *Antigens, Differentiation, Myelomonocytic
+ Prediabetic State/bl [Blood]
+ Prediabetic State/di [Diagnosis]
+ Prediabetic State/th [Therapy]
+ Prediabetic State/dt [Drug Therapy]
+ *Prediabetic State
+ Receptors, Cell Surface/bl [Blood]
+ *Receptors, Cell Surface
+ Treatment Outcome
+ Antigens, CD/bl [Blood]
+ *Antigens, CD
+ *Risk Reduction Behavior
+ Incretins/tu [Therapeutic Use]
+ Incretins/ae [Adverse Effects]
+ Incretins/bl [Blood]
+ *Incretins
+ Adult
+ Case-Control Studies
+ Time Factors
+ Down-Regulation
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Hypoglycemic Agents/ae [Adverse Effects]
+ Aged
+Keyword Heading
+ GLP-1 analogue
+ Immune cells
+ Obesity
+ T2DM
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The GLP-1 receptor agonist liraglutide is used to treat hyperglycemia in type 2 diabetes but is also known to induce weight loss, preserve the beta cell and reduce cardiovascular risk. The mechanisms underlying these effects are however still not completely known. Herein we explore the effect of liraglutide on markers of immune cell activity in a population of obese individuals with prediabetes or newly diagnosed type 2 diabetes mellitus.
+
+ METHOD: Plasma levels of the monocyte/macrophage markers, soluble (s)CD163 and sCD14, the neutrophil markers myeloperoxidase (MPO) and neutrophil gelatinase-associated lipocalin (NGAL),the T-cell markers sCD25 and T-cell immunoglobulin mucin domain-3 (sTIM-3) and the inflammatory marker TNF superfamily (TNFSF) member 14 (LIGHT/TNFSF14) were measured by enzyme-linked immunosorbent assays in obese individuals with prediabetes or diabetes diagnosed within the last 12 months, prior to and after comparable weight loss achieved with lifestyle changes (n = 20) or liraglutide treatment (n = 20), and in healthy subjects (n = 13).
+
+ RESULTS: At baseline, plasma levels of the macrophage marker sCD163, and the inflammatory marker LIGHT were higher in cases as compared to controls. Plasma levels of sCD14, NGAL, sTIM-3 and sCD25 did not differ at baseline between patients and controls. After weight reduction following lifestyle intervention or liraglutide treatment, sCD163 decreased significantly in the liraglutide group vs. lifestyle (between-group difference p = 0.023, adjusted for visceral adipose tissue and triglycerides basal values). MPO and LIGHT decreased significantly only in the liraglutide group (between group difference not significant). Plasma levels of MPO and in particular sCD163 correlated with markers of metabolic dysfunction and inflammation. After weight loss, only sCD163 showed a trend for decreased levels during OGTT, both in the whole cohort as in those of liraglutide vs lifestyle group.
+
+ CONCLUSION: Weight loss following treatment with liraglutide was associated with reduced circulating levels of sCD163 when compared to the same extent of weight loss after lifestyle changes. This might contribute to reduced cardiometabolic risk in individuals receiving treatment with liraglutide. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 839I73S42A (Liraglutide). 0 (CD163 antigen). 0 (Biomarkers). 0 (Antigens, Differentiation, Myelomonocytic). 0 (Receptors, Cell Surface). 0 (Antigens, CD). 0 (Incretins). 0 (Hypoglycemic Agents).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Comparative Study.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12933-024-02237-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Grannes&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Liraglutide+and+not+lifestyle+intervention+reduces+soluble+CD163+after+comparable+weight+loss+in+obese+participants+with+prediabetes+or+type+2+diabetes+mellitus.&volume=23&issue=1&spage=146&epage=&date=2024&doi=10.1186%2Fs12933-024-02237-8&pmid=38685051&sid=OVID:medline
+
+<76>
+Unique Identifier
+ 38685027
+Title
+ The associations of oxidative stress and inflammatory markers with obesity in Iranian population: MASHAD cohort study.
+Source
+ BMC Endocrine Disorders. 24(1):56, 2024 Apr 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ghazizadeh H; Mansoori A; Sahranavard T; Nasrabadi M; Hadiloo K; Andalibi NS; Azmon M; Tavallaei S; Timar A; Ferns GA; Ghayour-Mobarhan M
+Authors Full Name
+ Ghazizadeh, Hamideh; Mansoori, Amin; Sahranavard, Toktam; Nasrabadi, Mohamad; Hadiloo, Kaveh; Andalibi, Nazanin Sheikh; Azmon, Marzyeh; Tavallaei, Shima; Timar, Ameneh; Ferns, Gordon A; Ghayour-Mobarhan, Majid.
+Institution
+ Ghazizadeh, Hamideh. CALIPER Program, Division of Clinical Biochemistry, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
+ Mansoori, Amin. Department of Applied Mathematics, School of Mathematical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. am.ma7676@yahoo.com.
+ Sahranavard, Toktam. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Nasrabadi, Mohamad. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Hadiloo, Kaveh. Student Research Committee, School of Medicine, Zanjan University in Medical Science, Zanjan, Iran.
+ Andalibi, Nazanin Sheikh. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Azmon, Marzyeh. Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Tavallaei, Shima. Department of Biochemistry and Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Timar, Ameneh. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ferns, Gordon A. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH, UK.
+ Ghayour-Mobarhan, Majid. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. ghayourm@mums.ac.ir.
+MeSH Subject Headings
+ Humans
+ Male
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/co [Complications]
+ *Obesity
+ *Oxidative Stress
+ Iran/ep [Epidemiology]
+ Middle Aged
+ Female
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Adult
+ C-Reactive Protein/an [Analysis]
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Inflammation/bl [Blood]
+ Inflammation/ep [Epidemiology]
+ *Inflammation
+ Aged
+ *Body Mass Index
+ Uric Acid/bl [Blood]
+ *Uric Acid
+ Cohort Studies
+ Follow-Up Studies
+ Prognosis
+ Risk Factors
+Keyword Heading
+ Body mass index
+ Obesity
+ PAB
+ SOD1
+ Uric acid
+ hs-CRP
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Low-grade inflammation and stress oxidative condition play a role in the pathogenesis of obesity, and the serum levels of these markers, such as pro-oxidant-antioxidant balance (PAB), high-sensitivity C-reactive protein (hs-CRP), and uric acid may indicate obesity progression. In this study, we aimed to investigate the relationship between obesity with PAB, hs-CRP, and uric acid in the Iranian population.
+
+ METHODS: This study was derived from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. A total of 7985 subjects aged 35 to 65 years were divided into three groups according to body mass index (BMI) as: normal, overweight and obese groups. Anthropometric indices and biochemical parameters such as PAB, superoxide dismutase type 1 (SOD1), hs-CRP, and uric acid were measured in all the participants. We evaluated the association of obesity with inflammatory factors by using multivariate regression analysis. Also, those participants with hypertension, an endocrine disorder, history of cardiovascular diseases and diabetes mellitus were excluded from the study.
+
+ RESULTS: There was a positive significant correlation between BMI and serum PAB, hs-CRP and uric acid (p < 0.001). While no statistically significant relation was observed between BMI and SOD1 (p = 0.85). Multivariate regression analysis showed that the risk of overweight and obesity increased 1.02 and 1.03-fold according to increase 10 units of PAB raise in comparison to reference group (normal weight) [(odds ratio (OR): 1.02, 95% CI (1.01-1.03)] and [OR: 1.03, 95% CI (1.01-1.04)], respectively). In addition, hs-CRP serum concentration was significantly associated with a high risk of obesity [(OR: 1.02; 95% CI (1.01-1.03)]. While the high levels of serum uric acid were associated with increased odds of overweight and obesity risk [OR: 1.4; CI (1.39-1.58) and OR: 1.76; CI (1.63-1.89), respectively].
+
+ CONCLUSIONS: Generally, we showed a significant association between BMI and serum PAB, hs-CRP values and uric acid levels, suggesting the role of these factors as risk stratification factors for obesity. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12902-024-01590-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ghazizadeh&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=The+associations+of+oxidative+stress+and+inflammatory+markers+with+obesity+in+Iranian+population%3A+MASHAD+cohort+study.&volume=24&issue=1&spage=56&epage=&date=2024&doi=10.1186%2Fs12902-024-01590-9&pmid=38685027&sid=OVID:medline
+
+<77>
+Unique Identifier
+ 38367125
+Title
+ Transferrin Saturation, Serum Ferritin, and C-Reactive Protein vs. Serum Ferritin for an optimal Iron Deficiency Diagnosis in Candidates for Bariatric Surgery.
+Source
+ Obesity Surgery. 34(4):1174-1184, 2024 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Munoz MPS; Ramirez ZPB; Rodriguez ELM; Blandon JDR; Aguinaga SA; Orozco CAO; Yanez ARE
+Authors Full Name
+ Munoz, M Patricia Sanchez; Ramirez, Zuleyma P Bello; Rodriguez, Eduardo L Martinez; Blandon, Jose D Reyes; Aguinaga, Soledad Aldana; Orozco, Cesar A Ortiz; Yanez, Allison R Esparza.
+Institution
+ Munoz, M Patricia Sanchez. Bariatric and Metabolic Surgery Clinic, The Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Salvador Quevedo and Zubieta 750, Eastern Independence, C.P: 44340, Guadalajara, Jalisco, Mexico.
+ Ramirez, Zuleyma P Bello. Bariatric and Metabolic Surgery Clinic, The Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Salvador Quevedo and Zubieta 750, Eastern Independence, C.P: 44340, Guadalajara, Jalisco, Mexico. zuleymabello@hotmail.com.
+ Rodriguez, Eduardo L Martinez. Bariatric and Metabolic Surgery Clinic, The Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Salvador Quevedo and Zubieta 750, Eastern Independence, C.P: 44340, Guadalajara, Jalisco, Mexico.
+ Blandon, Jose D Reyes. Bariatric and Metabolic Surgery Clinic, The Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Salvador Quevedo and Zubieta 750, Eastern Independence, C.P: 44340, Guadalajara, Jalisco, Mexico.
+ Aguinaga, Soledad Aldana. Bariatric and Metabolic Surgery Clinic, The Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Salvador Quevedo and Zubieta 750, Eastern Independence, C.P: 44340, Guadalajara, Jalisco, Mexico.
+ Orozco, Cesar A Ortiz. General Surgery Department, The Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Salvador Quevedo and Zubieta 750, Eastern Independence, C.P: 44340, Guadalajara, Jalisco, Mexico.
+ Yanez, Allison R Esparza. University Center for Biological and Agricultural Sciences, University of Guadalajara, Ramon Padilla Sanchez 2100, The Needles, C.P: 44600, Zapopan, Jalisco, Mexico.
+MeSH Subject Headings
+ Humans
+ *Anemia, Iron-Deficiency
+ *Bariatric Surgery
+ Biomarkers
+ C-Reactive Protein/an [Analysis]
+ C-Reactive Protein/me [Metabolism]
+ Cross-Sectional Studies
+ Ferritins/an [Analysis]
+ Ferritins/bl [Blood]
+ Iron
+ *Iron Deficiencies
+ Obesity/co [Complications]
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+ Retrospective Studies
+ Transferrin/an [Analysis]
+ Transferrin/me [Metabolism]
+ *Transferrin
+ Transferrins
+ Inflammation/bl [Blood]
+ Inflammation/me [Metabolism]
+Keyword Heading
+ C-reactive protein
+ Ferritin
+ Iron deficiency
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Iron has different physiological processes and is regulated by hepcidin that is also an acute phase reactant, which increases with inflammation. Obesity produces a pro-inflammatory state, affecting directly the normal regulation of iron, causing ferritin (FER) deficiency. FER is used as the only indicator of the status of iron in patients with obesity, so the majority of them would be underdiagnosed, leading to a high prevalence of iron deficiency (ID) and anemia. The aim of this study is to evaluate the diagnostic tests: transferrin saturation (TS), FER, and C-reactive protein (CRP) vs. FER with the objective of analyzing the most accurate variable for the diagnosis of ID.
+
+ MATERIALS AND METHODS: We present a cross-sectional, analytical, and retrospective study, evaluating the diagnostic tests in 96 patients, to whom two methods were applied for the diagnosis of ID: method 1 (FER < 30 ng/mL) and method 2 divided into 2A (FER < 30 ng/mL), 2B (FER 30-100 ng/mL + CRP >= 5 mg/L), 2C (FER 100-300 ng/mL + CRP >= 5 mg/L + TS < 20%), and 2D (TS < 20%).
+
+ RESULTS: The prevalence of ID obtained using method 1 was 30.2% while 69.8% presented ID using total method 2, confirming an underdiagnosis of 39.6%.
+
+ CONCLUSION: The inflammatory state in patients with obesity must be considered in the diagnosis of ID. The use of TS, FER, and CRP has greater validity than the use of serum FER for the diagnosis of ID in patients with obesity. Copyright © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). 9007-73-2 (Ferritins). E1UOL152H7 (Iron). 0 (Transferrin). 0 (Transferrins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs11695-024-07081-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Munoz&issn=0960-8923&title=Obesity+Surgery&atitle=Transferrin+Saturation%2C+Serum+Ferritin%2C+and+C-Reactive+Protein+vs.+Serum+Ferritin+for+an+optimal+Iron+Deficiency+Diagnosis+in+Candidates+for+Bariatric+Surgery.&volume=34&issue=4&spage=1174&epage=1184&date=2024&doi=10.1007%2Fs11695-024-07081-z&pmid=38367125&sid=OVID:medline
+
+<78>
+Unique Identifier
+ 38284263
+Title
+ Reply to correspondence "Extracellular vesicle microRNA signatures as novel biomarkers in obese asthmatics".
+Source
+ Allergy. 79(5):1401-1402, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alhamdan F; Potaczek DP; Greulich T; Tost J; Garn H
+Author NameID
+ Potaczek, Daniel P; ORCID: https://orcid.org/0000-0003-0324-8506
+ Tost, Jorg; ORCID: https://orcid.org/0000-0002-2683-0817
+ Garn, Holger; ORCID: https://orcid.org/0000-0002-5178-4023
+Authors Full Name
+ Alhamdan, Fahd; Potaczek, Daniel P; Greulich, Timm; Tost, Jorg; Garn, Holger.
+Institution
+ Alhamdan, Fahd. Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Medical Faculty, Philipps University of Marburg, Marburg, Germany.
+ Alhamdan, Fahd. Department of Anesthesiology, Critical Care, and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, Massachusetts, USA.
+ Alhamdan, Fahd. Department of Immunology, Harvard Medical School, Boston, Massachusetts, USA.
+ Alhamdan, Fahd. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
+ Potaczek, Daniel P. Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Medical Faculty, Philipps University of Marburg, Marburg, Germany.
+ Potaczek, Daniel P. Center for Infection and Genomics of the Lung (CIGL), Member of the German Center for Lung Research (DZL) and Universities of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University of Giessen, Giessen, Germany.
+ Potaczek, Daniel P. Bioscientia MVZ Labor Mittelhessen GmbH, Giesen, Germany.
+ Greulich, Timm. Department of Medicine, Pulmonary and Critical Care Medicine, Member of the German Center for Lung Research (DZL), University Medical Center Giessen and Marburg, Marburg, Germany.
+ Tost, Jorg. Laboratory for Epigenetics & Environment, Centre National de Recherche en Genomique Humaine, CEA-Institut de Biologie Francois Jacob, Universite Paris-Saclay, Evry, France.
+ Garn, Holger. Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Medical Faculty, Philipps University of Marburg, Marburg, Germany.
+MeSH Subject Headings
+ Humans
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ Extracellular Vesicles/me [Metabolism]
+ *Extracellular Vesicles
+ Asthma/di [Diagnosis]
+ Asthma/ge [Genetics]
+ *Asthma
+ *Biomarkers
+ Obesity/co [Complications]
+ *Obesity
+Registry Number/Name of Substance
+ 0 (MicroRNAs). 0 (Biomarkers).
+Publication Type
+ Letter.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fall.16042
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alhamdan&issn=0105-4538&title=Allergy&atitle=Reply+to+correspondence+%22Extracellular+vesicle+microRNA+signatures+as+novel+biomarkers+in+obese+asthmatics%22.&volume=79&issue=5&spage=1401&epage=1402&date=2024&doi=10.1111%2Fall.16042&pmid=38284263&sid=OVID:medline
+
+<79>
+Unique Identifier
+ 38674875
+Title
+ Diet-Induced Early Inflammatory Response of Visceral Adipose Tissue in Healthy Male Wistar Rats.
+Source
+ Nutrients. 16(8), 2024 Apr 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dimitrov I; Stankova T; Angelova P; Boyadjiev N; Georgieva K; Dimov I; Bivolarska A; Draganova M; Gerginska F; Daskalova E; Gramatikov V; Delchev S
+Author NameID
+ Dimitrov, Iliyan; ORCID: https://orcid.org/0000-0001-8988-0072
+ Stankova, Teodora; ORCID: https://orcid.org/0000-0002-9520-1758
+ Bivolarska, Anelia; ORCID: https://orcid.org/0000-0002-2157-3858
+ Gerginska, Fanka; ORCID: https://orcid.org/0000-0003-2880-5794
+ Daskalova, Elena; ORCID: https://orcid.org/0000-0002-6661-0747
+ Delchev, Slavi; ORCID: https://orcid.org/0000-0001-8607-6986
+Authors Full Name
+ Dimitrov, Iliyan; Stankova, Teodora; Angelova, Penka; Boyadjiev, Nikolay; Georgieva, Katerina; Dimov, Ivica; Bivolarska, Anelia; Draganova, Milena; Gerginska, Fanka; Daskalova, Elena; Gramatikov, Vilian; Delchev, Slavi.
+Institution
+ Dimitrov, Iliyan. Department of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Stankova, Teodora. Department of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Angelova, Penka. Department of Physiology, Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Boyadjiev, Nikolay. Department of Physiology, Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Georgieva, Katerina. Department of Physiology, Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Dimov, Ivica. Department of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Bivolarska, Anelia. Department of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Draganova, Milena. Department of Medical Biology, Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Draganova, Milena. Research Institute, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Gerginska, Fanka. Department of Human Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Daskalova, Elena. Department of Human Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+ Gramatikov, Vilian. Faculty of Medicine, Medical University, 4002 Plovdiv, Bulgaria.
+ Delchev, Slavi. Department of Human Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
+MeSH Subject Headings
+ Animals
+ Male
+ Intra-Abdominal Fat/me [Metabolism]
+ *Intra-Abdominal Fat
+ *Rats, Wistar
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ *Inflammation
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Rats
+ Serum Amyloid A Protein/me [Metabolism]
+ Interleukin-4/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Adipocytes
+ Obesity/me [Metabolism]
+ Obesity/et [Etiology]
+Keyword Heading
+ CRP
+ IL-4
+ SAA
+ animal model
+ high-fat diet
+ low-grade inflammation
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The prolonged consumption of a high-fat diet (HFD) leads to abnormal growth of the visceral adipose tissue (VAT), increased macrophage infiltration, and altered secretion of biologically active molecules. This is considered as a precondition for the development of obesity, inflammation, and obesity-related disorders. Therefore, we studied HFD-induced changes in the tissue levels of the inflammatory markers C-reactive protein, serum amyloid-A, and interleukin-4 in healthy male Wistar rats. The animals were first divided at random into two groups subjected to either a standard or a high-fat diet. The initial effect of the diet was evaluated after fourteen weeks. In order to study the diet duration effect, the standard diet was given to twelve animals from the HFD group, while the remaining continued with the HFD for an additional four weeks. Our results showed that the HFD barely affected body mass index, conicity, relative fat mass, and Lee indices, whereas it provoked adipocyte hypertrophy and gradually increased the levels of both the pro- and anti-inflammatory markers. The switch from the high-fat to the standard diet resulted in the comparatively fast restoration of the baseline levels of the studied molecules. Although, the prolonged consumption of an HFD causes adipocyte hypertrophy in healthy male animals, the inflammatory process in VAT is well-coordinated, time-dependent, and reversible.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Serum Amyloid A Protein). 207137-56-2 (Interleukin-4). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu16081184
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dimitrov&issn=2072-6643&title=Nutrients&atitle=Diet-Induced+Early+Inflammatory+Response+of+Visceral+Adipose+Tissue+in+Healthy+Male+Wistar+Rats.&volume=16&issue=8&spage=&epage=&date=2024&doi=10.3390%2Fnu16081184&pmid=38674875&sid=OVID:medline
+
+<80>
+Unique Identifier
+ 38369640
+Title
+ Prepregnancy weight loss and maternal metabolic and inflammatory biomarkers during pregnancy: An analysis of National Health and Nutrition Examination Survey.
+Source
+ Journal of Obstetrics & Gynaecology Research. 50(5):809-820, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yu Y; Ma Q; Groth S
+Author NameID
+ Yu, Yang; ORCID: https://orcid.org/0000-0003-3635-1139
+Authors Full Name
+ Yu, Yang; Ma, Qianheng; Groth, Susan.
+Institution
+ Yu, Yang. School of Nursing, University of Rochester, Rochester, New York, USA.
+ Ma, Qianheng. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
+ Groth, Susan. School of Nursing, University of Rochester, Rochester, New York, USA.
+MeSH Subject Headings
+ Humans
+ Female
+ Pregnancy
+ *Weight Loss
+ Adult
+ Retrospective Studies
+ *Nutrition Surveys
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ C-Reactive Protein/an [Analysis]
+ C-Reactive Protein/me [Metabolism]
+ Young Adult
+ Inflammation/bl [Blood]
+ Pregnancy Complications/bl [Blood]
+ Obesity/bl [Blood]
+Keyword Heading
+ inflammation
+ metabolism
+ obesity
+ pregnancy
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Women with overweight or obesity are recommended to lose weight before conception to optimize pregnancy outcomes. However, the obstetrical implications of prepregnancy weight loss have been minimally examined. The objective of this study was to investigate the association between prepregnancy weight loss and maternal metabolic and inflammatory profiles during a subsequent pregnancy.
+
+ METHODS: This study was a retrospective analysis of National Health and Nutrition Examination Survey data (2003-2018). Participants were women who were pregnant at the time of assessment. Prepregnancy weight loss was described as percent weight change based on self-reported baseline (1 year before pregnancy) and prepregnancy weight. Metabolic (e.g., blood pressure [BP]) and inflammatory biomarkers (i.e., high-sensitivity C-reactive protein [hs-CRP]) were determined by standard medical tests. Statistical analyses included linear regressions with appropriate imputation, weighting, and variance estimation techniques.
+
+ RESULTS: Participants (N = 236) reported a mean percent weight loss of 4.6% (standard error [SE] = 0.3%) during the year before pregnancy. Regression models showed that prepregnancy weight loss was inversely associated with levels of total cholesterol (beta = -1.24, p = 0.01), low-density lipoprotein-cholesterol (beta = -0.79, p < 0.01), and high-density lipoprotein-cholesterol (beta = -0.18, p < 0.01). The effect of prepregnancy weight loss on BP, insulin sensitivity, and hs-CRP was not significant, although there was a trend toward higher levels of diastolic BP (beta = 0.24, p = 0.07) and hs-CRP (beta = 0.10, p = 0.08).
+
+ CONCLUSIONS: This study found favorable changes in lipid profiles following prepregnancy weight loss. Due to limitations such as a relatively small sample size, self-reported weight measures, and missing data on several outcome variables, future studies are needed to confirm study findings. Copyright © 2024 Japan Society of Obstetrics and Gynecology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fjog.15904
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yu&issn=1341-8076&title=Journal+of+Obstetrics+%26+Gynaecology+Research&atitle=Prepregnancy+weight+loss+and+maternal+metabolic+and+inflammatory+biomarkers+during+pregnancy%3A+An+analysis+of+National+Health+and+Nutrition+Examination+Survey.&volume=50&issue=5&spage=809&epage=820&date=2024&doi=10.1111%2Fjog.15904&pmid=38369640&sid=OVID:medline
+
+<81>
+Unique Identifier
+ 38658930
+Title
+ The effect of obesity and subsequent weight reduction on cardiac morphology and function in cats.
+Source
+ BMC Veterinary Research [Electronic Resource]. 20(1):154, 2024 Apr 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Partington C; Hodgkiss-Geere H; Woods GRT; Dukes-McEwan J; Flanagan J; Biourge V; German AJ
+Authors Full Name
+ Partington, Catheryn; Hodgkiss-Geere, Hannah; Woods, Georgia R T; Dukes-McEwan, Joanna; Flanagan, John; Biourge, Vincent; German, Alexander J.
+Institution
+ Partington, Catheryn. Institute of Infection, Veterinary, Ecological and Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Neston, UK. cgrp2@cam.ac.uk.
+ Partington, Catheryn. Present address: Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK. cgrp2@cam.ac.uk.
+ Hodgkiss-Geere, Hannah. Institute of Infection, Veterinary, Ecological and Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Neston, UK.
+ Woods, Georgia R T. Institute of Life Course and Medical Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Neston, UK.
+ Dukes-McEwan, Joanna. Institute of Infection, Veterinary, Ecological and Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Neston, UK.
+ Flanagan, John. Royal Canin Research Center, Aimargues, France.
+ Biourge, Vincent. Royal Canin Research Center, Aimargues, France.
+ German, Alexander J. Institute of Life Course and Medical Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Neston, UK.
+MeSH Subject Headings
+ Animals
+ Cats
+ Obesity/ve [Veterinary]
+ Obesity/pp [Physiopathology]
+ *Obesity
+ Male
+ *Weight Loss
+ Cat Diseases/pp [Physiopathology]
+ Cat Diseases/dg [Diagnostic Imaging]
+ *Cat Diseases
+ Female
+ *Body Composition
+ Echocardiography/ve [Veterinary]
+ *Echocardiography
+ Prospective Studies
+ Heart Rate
+ Blood Pressure
+ Heart
+ Biomarkers/bl [Blood]
+ Electrocardiography/ve [Veterinary]
+Keyword Heading
+ Cardiac biomarkers
+ Diastolic function
+ Echocardiography
+ Hypertrophic cardiomyopathy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In people, obesity is a risk factor for cardiovascular disease, associated with systemic hypertension, cardiac remodelling and systolic and diastolic dysfunction. Weight reduction can reverse myocardial remodelling and reduce risk of subsequent cardiovascular disease. In cats, far less is known regarding the effects of obesity and subsequent weight reduction on cardiovascular morphology and function. This prospective study aimed to assess cardiac morphology and function, heart rate variability, cardiac biomarkers and body composition before and after controlled weight reduction in cats with obesity. Body composition analysis (by dual energy x-ray absorptiometry, DEXA) and cardiovascular assessment (echocardiography, systemic arterial systolic blood pressure, electrocardiography, plasma cardiac biomarkers) were performed prior to weight management in twenty cats with obesity. These investigations were repeated in eleven cats that reached target weight.
+
+ RESULTS: At baseline, systemic hypertension was not documented, but the majority of cats with obesity (15 out of 19) showed echocardiographic evidence of diastolic dysfunction. Eleven of 20 cats had increased maximal end-diastolic septal or left ventricular free wall thickness (>= 6.0 mm) at baseline. Median (interquartile range) percentage of weight lost in the cats reaching target weight was 26% (17-29%), with a median reduction in body fat mass of 45% (26-64%). Both the end-diastolic left ventricular free wall (median magnitude of change -0.85 mm, IQR -0.05 mm to -1.55 mm, P = 0.019; median percentage reduction 14.0%) and end-diastolic interventricular septum (median magnitude of change -0.5 mm, IQR -0.2 mm to -1.225 mm, P = 0.047; median percentage reduction 7.9%) thickness decreased after weight reduction. Following weight reduction, pulsed wave tissue Doppler imaging of the left ventricular free wall was consistent with improved diastolic function in 4 out of 8 cats, however there was no significant difference in overall diastolic function class. Further, there was no change in heart rate variability or cardiac biomarkers with weight reduction.
+
+ CONCLUSION: An increase in left ventricular wall thickness and diastolic dysfunction were common echocardiographic features in cats with obesity within our study and may be reversible with successful weight and fat mass loss. Further studies are required to clarify the clinical consequences of these findings. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12917-024-04011-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Partington&issn=1746-6148&title=BMC+Veterinary+Research+%5BElectronic+Resource%5D&atitle=The+effect+of+obesity+and+subsequent+weight+reduction+on+cardiac+morphology+and+function+in+cats.&volume=20&issue=1&spage=154&epage=&date=2024&doi=10.1186%2Fs12917-024-04011-0&pmid=38658930&sid=OVID:medline
+
+<82>
+Unique Identifier
+ 38654925
+Title
+ Hair cortisol levels are associated with overweight and obesity in the ELSA-Brasil cohort.
+Source
+ Frontiers in Endocrinology. 15:1361715, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rodrigues KL; Scaranni PODS; Pereira ENGDS; da Silva VVD; Silvares RR; de Araujo BP; Castilho C; Schmidt MI; da Fonseca MJM; Griep RH; Daliry A
+Authors Full Name
+ Rodrigues, Karine Lino; Scaranni, Patricia de Oliveira da Silva; Pereira, Evelyn Nunes Goulart da Silva; da Silva, Vivian Vieira Dias; Silvares, Raquel Rangel; de Araujo, Beatriz Peres; Castilho, Cristina; Schmidt, Maria Ines; da Fonseca, Maria de Jesus Mendes; Griep, Rosane Harter; Daliry, Anissa.
+Institution
+ Rodrigues, Karine Lino. Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
+ Scaranni, Patricia de Oliveira da Silva. Gaffree and Guinle University Hospital, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
+ Pereira, Evelyn Nunes Goulart da Silva. Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
+ da Silva, Vivian Vieira Dias. Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
+ Silvares, Raquel Rangel. Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
+ de Araujo, Beatriz Peres. Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
+ Castilho, Cristina. Department of Public Health, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
+ Schmidt, Maria Ines. Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
+ da Fonseca, Maria de Jesus Mendes. National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
+ Griep, Rosane Harter. Laboratory of Environmental and Health Education, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
+ Daliry, Anissa. Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
+MeSH Subject Headings
+ Humans
+ Hydrocortisone/me [Metabolism]
+ Hydrocortisone/an [Analysis]
+ *Hydrocortisone
+ Hair/ch [Chemistry]
+ Hair/me [Metabolism]
+ *Hair
+ Male
+ Female
+ Middle Aged
+ Obesity/me [Metabolism]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Cross-Sectional Studies
+ Overweight/me [Metabolism]
+ Overweight/ep [Epidemiology]
+ *Overweight
+ Brazil/ep [Epidemiology]
+ Adult
+ Longitudinal Studies
+ Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ Aged
+ Cohort Studies
+Keyword Heading
+ ELSA-Brasil
+ chronic stress
+ hair cortisol levels
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction: Hair cortisol level has recently been identified as a promising marker for detecting long-term cortisol levels and a marker of hypothalamic-pituitary-adrenal cortex (HPA) axis activity. However, research on the association between obesity and an altered cortisol metabolism remains controversial.
+
+ Objective: This study aimed to investigate the relationship between hair cortisol levels and overweight and obesity in participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
+
+ Methods: This was a cross-sectional study involving 2,499 participants from the second follow-up (visit 3, 2017-2019) attending research centers in Rio de Janeiro and Rio Grande do Sul states. Hair samples were collected, and cortisol levels were analyzed using enzyme-linked immunosorbent assay (ELISA) kits. Cortisol levels were classified as low (< 40 pg/mg), medium (40-128 pg/mg), or high (> 128 pg/mg). The participants were classified as eutrophic, overweight, or obese according to their weight (kg) and height (m2). Odds ratios (ORs) with 95% confidence intervals (95%CI) were estimated.
+
+ Results: Of the 2499 individuals, 30% had eutrophic weight, 40% were overweight, and 30% were obese. Notably, cortisol levels gradually increased with increasing body weight. Among participants with high hair cortisol levels, 41.2% were classified as overweight and 34.2% as obese. Multinomial logistic regression analysis indicated that participants with high cortisol levels were 43% (OR =1.43; 95%CI: 1.02-2.03) more likely to be overweight and 72% (OR =1.72; 95%CI:1.20-2.47) more likely to be obese than participants with low hair cortisol levels. After adjustment for all covariates, high cortisol levels remained associated with obesity (OR = 1.54; 95%CI:1.02-2.31) and overweight (OR =1.33; 95%CI:0.91-1.94).
+
+ Conclusion: In the ELSA-Brazil cohort, hair stress were positively associated with overweight and obesity. These results underscore the importance of considering stress and cortisol as potential factors in obesity prevention and intervention efforts, and highlight a novel aspect of the complex relationship between stress and obesity in the Brazilian population. Copyright © 2024 Rodrigues, Scaranni, Pereira, da Silva, Silvares, de Araujo, Castilho, Schmidt, Fonseca, Griep and Daliry.
+Registry Number/Name of Substance
+ WI4X0X7BPJ (Hydrocortisone). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3389%2ffendo.2024.1361715
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rodrigues&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Hair+cortisol+levels+are+associated+with+overweight+and+obesity+in+the+ELSA-Brasil+cohort.&volume=15&issue=&spage=1361715&epage=&date=2024&doi=10.3389%2Ffendo.2024.1361715&pmid=38654925&sid=OVID:medline
+
+<83>
+Unique Identifier
+ 38612986
+Title
+ Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence.
+Source
+ Nutrients. 16(7), 2024 Mar 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Balasubramanian P; Kiss T; Gulej R; Nyul Toth A; Tarantini S; Yabluchanskiy A; Ungvari Z; Csiszar A
+Author NameID
+ Kiss, Tamas; ORCID: https://orcid.org/0000-0001-5339-5227
+ Gulej, Rafal; ORCID: https://orcid.org/0000-0002-9958-707X
+ Tarantini, Stefano; ORCID: https://orcid.org/0000-0001-5627-1430
+Authors Full Name
+ Balasubramanian, Priya; Kiss, Tamas; Gulej, Rafal; Nyul Toth, Adam; Tarantini, Stefano; Yabluchanskiy, Andriy; Ungvari, Zoltan; Csiszar, Anna.
+Institution
+ Balasubramanian, Priya. Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Balasubramanian, Priya. Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Balasubramanian, Priya. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Kiss, Tamas. Cerebrovascular and Neurocognitive Disorders Research Group, Eotvos Lorand Research Network, Semmelweis University, 1094 Budapest, Hungary.
+ Kiss, Tamas. International Training Program in Geroscience, First Department of Pediatrics, Semmelweis University, 1089 Budapest, Hungary.
+ Gulej, Rafal. Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Gulej, Rafal. Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Nyul Toth, Adam. Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Nyul Toth, Adam. Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Nyul Toth, Adam. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Nyul Toth, Adam. Cerebrovascular and Neurocognitive Disorders Research Group, Eotvos Lorand Research Network, Semmelweis University, 1094 Budapest, Hungary.
+ Tarantini, Stefano. Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Tarantini, Stefano. Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Tarantini, Stefano. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Tarantini, Stefano. Cerebrovascular and Neurocognitive Disorders Research Group, Eotvos Lorand Research Network, Semmelweis University, 1094 Budapest, Hungary.
+ Tarantini, Stefano. Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Yabluchanskiy, Andriy. Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Yabluchanskiy, Andriy. Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Yabluchanskiy, Andriy. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Yabluchanskiy, Andriy. Cerebrovascular and Neurocognitive Disorders Research Group, Eotvos Lorand Research Network, Semmelweis University, 1094 Budapest, Hungary.
+ Yabluchanskiy, Andriy. Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Ungvari, Zoltan. Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Ungvari, Zoltan. Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Ungvari, Zoltan. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Ungvari, Zoltan. Cerebrovascular and Neurocognitive Disorders Research Group, Eotvos Lorand Research Network, Semmelweis University, 1094 Budapest, Hungary.
+ Ungvari, Zoltan. Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Csiszar, Anna. Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Csiszar, Anna. Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Csiszar, Anna. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Csiszar, Anna. Cerebrovascular and Neurocognitive Disorders Research Group, Eotvos Lorand Research Network, Semmelweis University, 1094 Budapest, Hungary.
+MeSH Subject Headings
+ Animals
+ Mice
+ NF-E2-Related Factor 2/ge [Genetics]
+ Diet, High-Fat/ae [Adverse Effects]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2
+ *Resilience, Psychological
+ Cellular Senescence
+ Aging
+ Obesity/et [Etiology]
+ Biomarkers
+Keyword Heading
+ ageing
+ endothelial cells
+ high-fat diet
+ obesity
+ prediabetes
+ senescence
+ stress resistance
+ unhealthy diet
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies have compellingly linked HFD consumption to obesity and the development of type 2 diabetes mellitus. Moreover, the synergistic interplay of HFD, obesity, and diabetes expedites the aging process and prematurely fosters age-related diseases. However, the underlying mechanisms driving these associations remain enigmatic. One of the most conspicuous hallmarks of aging is the accumulation of highly inflammatory senescent cells, with mounting evidence implicating increased cellular senescence in the pathogenesis of age-related diseases. Our hypothesis posits that HFD consumption amplifies senescence burden across multiple organs. To scrutinize this hypothesis, we subjected mice to a 6-month HFD regimen, assessing senescence biomarker expression in the liver, white adipose tissue, and the brain. Aging is intrinsically linked to impaired cellular stress resilience, driven by dysfunction in Nrf2-mediated cytoprotective pathways that safeguard cells against oxidative stress-induced senescence. To ascertain whether Nrf2-mediated pathways shield against senescence induction in response to HFD consumption, we explored senescence burden in a novel model of aging: Nrf2-deficient (Nrf2+/-) mice, emulating the aging phenotype. Our initial findings unveiled significant Nrf2 dysfunction in Nrf2+/- mice, mirroring aging-related alterations. HFD led to substantial obesity, hyperglycemia, and impaired insulin sensitivity in both Nrf2+/- and Nrf2+/+ mice. In control mice, HFD primarily heightened senescence burden in white adipose tissue, evidenced by increased Cdkn2a senescence biomarker expression. In Nrf2+/- mice, HFD elicited a significant surge in senescence burden across the liver, white adipose tissue, and the brain. We postulate that HFD-induced augmentation of senescence burden may be a pivotal contributor to accelerated organismal aging and the premature onset of age-related diseases.
+Registry Number/Name of Substance
+ 0 (NF-E2-Related Factor 2). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu16070952
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Balasubramanian&issn=2072-6643&title=Nutrients&atitle=Accelerated+Aging+Induced+by+an+Unhealthy+High-Fat+Diet%3A+Initial+Evidence+for+the+Role+of+Nrf2+Deficiency+and+Impaired+Stress+Resilience+in+Cellular+Senescence.&volume=16&issue=7&spage=&epage=&date=2024&doi=10.3390%2Fnu16070952&pmid=38612986&sid=OVID:medline
+
+<84>
+Unique Identifier
+ 38599666
+Title
+ Overnutrition is a risk factor for iron, but not for zinc or vitamin A deficiency in children and young people: a systematic review and meta-analysis.
+Source
+ BMJ Global Health. 9(4), 2024 Apr 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tan X; Tan PY; Gong YY; Moore JB
+Author NameID
+ Tan, Xiaomian; ORCID: http://orcid.org/0000-0002-8299-1439
+ Tan, Pui Yee; ORCID: http://orcid.org/0000-0003-1281-4928
+ Gong, Yun Yun; ORCID: http://orcid.org/0000-0003-4927-5526
+ Moore, J Bernadette; ORCID: http://orcid.org/0000-0003-4750-1550
+Authors Full Name
+ Tan, Xiaomian; Tan, Pui Yee; Gong, Yun Yun; Moore, J Bernadette.
+Institution
+ Tan, Xiaomian. School of Food Science and Nutrition, University of Leeds, Leeds, West Yorkshire, UK.
+ Tan, Pui Yee. School of Food Science and Nutrition, University of Leeds, Leeds, West Yorkshire, UK.
+ Gong, Yun Yun. School of Food Science and Nutrition, University of Leeds, Leeds, West Yorkshire, UK.
+ Moore, J Bernadette. School of Food Science and Nutrition, University of Leeds, Leeds, West Yorkshire, UK j.b.moore@leeds.ac.uk.
+MeSH Subject Headings
+ Child
+ Humans
+ Adolescent
+ Iron
+ Vitamin A Deficiency/ep [Epidemiology]
+ *Vitamin A Deficiency
+ Zinc
+ Overweight/co [Complications]
+ Anemia, Iron-Deficiency/et [Etiology]
+ Anemia, Iron-Deficiency/pc [Prevention & Control]
+ *Anemia, Iron-Deficiency
+ Micronutrients
+ Overnutrition/ep [Epidemiology]
+ Overnutrition/co [Complications]
+ *Overnutrition
+ Vitamin A
+ Obesity/co [Complications]
+ Risk Factors
+ Biomarkers
+Keyword Heading
+ Child health
+ Nutrition
+ Public Health
+ Systematic review
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Traditionally associated with undernutrition, increasing evidence suggests micronutrient deficiencies can coexist with overnutrition. Therefore, this work aimed to systematically review the associations between iron, zinc and vitamin A (VA) status and weight status (both underweight and overweight) in children and young people.
+
+ METHODS: Ovid Medline, Ovid Embase, Scopus and Cochrane databases were systematically searched for observational studies assessing micronutrient status (blood, serum or plasma levels of iron, zinc or VA biomarkers) and weight status (body mass index or other anthropometric measurement) in humans under 25 years of any ethnicity and gender. Risk of bias assessment was conducted using the American Dietetic Association Quality Criteria Checklist. Where possible, random effects restricted maximum likelihood meta-analyses were performed.
+
+ RESULTS: After screening, 83 observational studies involving 190 443 participants from 44 countries were identified, with many studies having reported on more than one micronutrient and/or weight status indicator. Iron was the most investigated micronutrient, with 46, 28 and 27 studies reporting data for iron, zinc and VA status, respectively. Synthesising 16 records of OR from seven eligible studies, overnutrition (overweight and obesity) increased odds of iron deficiency (ID) (OR (95% CI): 1.51 (1.20 to 1.82), p<0.0001, I2=40.7%). Odds appeared to be higher for children living with obesity (1.88 (1.33 to 2.43), p<0.0001, I2=20.6%) in comparison to those with overweight (1.31 (0.98 to 1.64), p<0.0001, I2=40.5%), although between group differences were not significant (p=0.08).
+
+ CONCLUSIONS: Overnutrition is associated with increased risk of ID, but not zinc or VA deficiencies, with an inverted U-shaped relationship observed between iron status and bodyweight. Our results highlight significant heterogeneity in the reporting of micronutrient biomarkers and how deficiencies were defined. Inflammation status was rarely adequately accounted for, and the burden of ID may well be under-recognised, particularly in children and young people living with overnutrition.
+
+ PROSPERO REGISTRATION NUMBER: CRD42020221523. Copyright © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.
+Registry Number/Name of Substance
+ E1UOL152H7 (Iron). J41CSQ7QDS (Zinc). 0 (Micronutrients). 11103-57-4 (Vitamin A). 0 (Biomarkers).
+Publication Type
+ Meta-Analysis. Systematic Review. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1136%2fbmjgh-2024-015135
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tan&issn=2059-7908&title=BMJ+Global+Health&atitle=Overnutrition+is+a+risk+factor+for+iron%2C+but+not+for+zinc+or+vitamin+A+deficiency+in+children+and+young+people%3A+a+systematic+review+and+meta-analysis.&volume=9&issue=4&spage=&epage=&date=2024&doi=10.1136%2Fbmjgh-2024-015135&pmid=38599666&sid=OVID:medline
+
+<85>
+Unique Identifier
+ 38511219
+Title
+ Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner.
+Source
+ American Journal of Physiology - Renal Physiology. 326(5):F727-F736, 2024 May 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ do Carmo JM; Hall JE; Dai X; Aitkens N; Larson K; Luna-Suarez EM; Wang Z; Omoto ACM; Mouton A; Li X; Furukawa LNS; Woronik V; da Silva AA
+Author NameID
+ do Carmo, Jussara M; ORCID: https://orcid.org/0000-0003-0471-0512
+ Aitkens, Nikaela; ORCID: https://orcid.org/0000-0003-3480-5985
+ Wang, Zhen; ORCID: https://orcid.org/0000-0002-8028-8942
+ Omoto, Ana C M; ORCID: https://orcid.org/0000-0003-1062-7109
+ Mouton, Alan; ORCID: https://orcid.org/0000-0001-5973-3071
+ Li, Xuan; ORCID: https://orcid.org/0000-0001-5781-1662
+ Furukawa, Luzia N S; ORCID: https://orcid.org/0000-0002-0457-6651
+ da Silva, Alexandre A; ORCID: https://orcid.org/0000-0003-4504-0607
+Authors Full Name
+ do Carmo, Jussara M; Hall, John E; Dai, Xuemei; Aitkens, Nikaela; Larson, Kylie; Luna-Suarez, Emilio M; Wang, Zhen; Omoto, Ana C M; Mouton, Alan; Li, Xuan; Furukawa, Luzia N S; Woronik, Viktoria; da Silva, Alexandre A.
+Institution
+ do Carmo, Jussara M. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Hall, John E. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Dai, Xuemei. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Aitkens, Nikaela. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Larson, Kylie. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Luna-Suarez, Emilio M. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Wang, Zhen. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Omoto, Ana C M. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Mouton, Alan. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Li, Xuan. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+ Furukawa, Luzia N S. Laboratory of Renal Pathophysiology, Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil.
+ Woronik, Viktoria. Laboratory of Renal Pathophysiology, Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil.
+ da Silva, Alexandre A. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
+MeSH Subject Headings
+ Animals
+ Male
+ Female
+ *Mice, Inbred C57BL
+ Reperfusion Injury/pa [Pathology]
+ Reperfusion Injury/me [Metabolism]
+ *Reperfusion Injury
+ Acute Kidney Injury/et [Etiology]
+ Acute Kidney Injury/me [Metabolism]
+ Acute Kidney Injury/pp [Physiopathology]
+ Acute Kidney Injury/pa [Pathology]
+ *Acute Kidney Injury
+ Kidney/pp [Physiopathology]
+ Kidney/pa [Pathology]
+ Kidney/me [Metabolism]
+ *Kidney
+ Sex Factors
+ Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Diet, High-Fat
+ Pregnancy
+ Lipocalin-2/me [Metabolism]
+ Obesity, Maternal/me [Metabolism]
+ Obesity, Maternal/co [Complications]
+ Obesity, Maternal/pp [Physiopathology]
+ Prenatal Exposure Delayed Effects
+ Mice
+ Risk Factors
+ Disease Models, Animal
+ Biomarkers/bl [Blood]
+Keyword Heading
+ acute kidney injury
+ chronic kidney disease
+ developmental programming
+ hypertension
+ sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Although obesity is recognized as a risk factor for cardiorenal and metabolic diseases, the impact of parental obesity on the susceptibility of their offspring to renal injury at adulthood is unknown. We examined the impact of parental obesity on offspring kidney function, morphology, and markers of kidney damage after acute kidney injury (AKI). Offspring from normal (N) diet-fed C57BL/6J parents were fed either N (NN) or a high-fat (H) diet (NH) from weaning until adulthood. Offspring from obese H diet-fed parents were fed N (HN) or H diet (HH) after weaning. All offspring groups were submitted to bilateral AKI by clamping the left and right renal pedicles for 30 min. Compared with male NH and NN offspring from lean parents, male HH and HN offspring from obese parents exhibited higher kidney injury markers such as urinary, renal osteopontin, plasma creatinine, urinary albumin excretion, and neutrophil gelatinase-associated lipocalin (NGAL) levels, and worse histological injury score at 22 wk of age. Only albumin excretion and NGAL were elevated in female HH offspring from obese parents compared with lean and obese offspring from lean parents. We also found an increased mortality rate and worse kidney injury scores after AKI in male offspring from obese parents, regardless of the diet consumed after weaning. Female offspring were protected from major kidney injury after AKI. These results indicate that parental obesity leads to increased kidney injury in their offspring after ischemia-reperfusion in a sex-dependent manner, even when their offspring remain lean. NEW & NOTEWORTHY Offspring from obese parents are more susceptible to kidney injury and worse outcomes following an acute ischemia-reperfusion insult. Male, but not female, offspring from obese parents exhibit increased blood pressure early in life. Female offspring are partially protected against major kidney injury induced by ischemia-reperfusion.
+Registry Number/Name of Substance
+ 0 (Lipocalin-2). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1152%2fajprenal.00294.2023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=do+Carmo&issn=1522-1466&title=American+Journal+of+Physiology+-+Renal+Physiology&atitle=Parental+obesity+predisposes+offspring+to+kidney+dysfunction+and+increased+susceptibility+to+ischemia-reperfusion+injury+in+a+sex-dependent+manner.&volume=326&issue=5&spage=F727&epage=F736&date=2024&doi=10.1152%2Fajprenal.00294.2023&pmid=38511219&sid=OVID:medline
+
+<86>
+Unique Identifier
+ 38310736
+Title
+ Fasting plasma lactate as a possible early clinical marker for metabolic disease risk.
+Source
+ Diabetes & Metabolic Syndrome. 18(2):102955, 2024 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Broskey NT; Pories WJ; DeMaria EJ; Jones TE; Tanner CJ; Zheng D; Krassovskaia PM; Mitchell LA; Matarese LE; O'Brien KF; Cortright RN; Dohm GL; Houmard JA
+Authors Full Name
+ Broskey, Nicholas T; Pories, Walter J; DeMaria, Eric J; Jones, Terry E; Tanner, Charles J; Zheng, Donghai; Krassovskaia, Polina M; Mitchell, Lindsay A; Matarese, Laura E; O'Brien, Kevin F; Cortright, Ronald N; Dohm, G Lynis; Houmard, Joseph A.
+Institution
+ Broskey, Nicholas T. Departments of Kinesiology, East Carolina University, Greenville, NC, USA; Surgery, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA. Electronic address: broskeyn19@ecu.edu.
+ Pories, Walter J. Surgery, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
+ DeMaria, Eric J. Surgery, East Carolina University, Greenville, NC, USA.
+ Jones, Terry E. Physical Therapy, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
+ Tanner, Charles J. Departments of Kinesiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
+ Zheng, Donghai. Departments of Kinesiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
+ Krassovskaia, Polina M. Departments of Kinesiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
+ Mitchell, Lindsay A. Physical Therapy, East Carolina University, Greenville, NC, USA.
+ Matarese, Laura E. Surgery, East Carolina University, Greenville, NC, USA; Internal Medicine, East Carolina University, Greenville, NC, USA.
+ O'Brien, Kevin F. Public Health, East Carolina University, Greenville, NC, USA.
+ Cortright, Ronald N. Departments of Kinesiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; Physiology, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
+ Dohm, G Lynis. Physiology, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
+ Houmard, Joseph A. Departments of Kinesiology, East Carolina University, Greenville, NC, USA; Surgery, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
+MeSH Subject Headings
+ Female
+ Humans
+ Male
+ Biomarkers
+ Fasting
+ Insulin
+ *Insulin Resistance
+ Lactic Acid
+ *Metabolic Syndrome
+ Obesity/co [Complications]
+ Young Adult
+ Adult
+Keyword Heading
+ Clinical marker
+ Diabetes risk
+ Insulin resistance
+ Lactate
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: Elevated fasting plasma lactate concentrations are evident in individuals with metabolic diseases. However, it has yet to be determined if these associations exist in a young, healthy population as a possible early marker for metabolic disease risk. The purpose of this study was to determine if indices of the metabolic syndrome are related to plasma lactate concentrations in this population.
+
+ METHODS: Fifty (29 +/- 7 yr) men (n = 19) and women (n = 31) classified as overweight (26.4 +/- 1.8 kg/m2) participated in this observational study. Blood pressure and blood metabolites were measured after an overnight fast. Lactate was also measured before and after a three-day eucaloric high-fat (70 %) diet. The homeostatic model assessment for insulin resistance (HOMA-IR) was calculated as a measure of insulin resistance. Visceral adipose tissue mass was determined via dual X-ray absorptiometry.
+
+ RESULTS: Triglycerides (r = 0.55, p=<0.0001), HOMA-IR (r = 0.53, p=<0.0001), and systolic and diastolic (both, r = 0.36, p = 0.01) blood pressures associated with fasting plasma lactate. No differences in visceral adipose tissue existed between the sexes (p = 0.41); however, the relationship between visceral adipose tissue and lactate existed only in females (r = 0.59, p = 0.02) but not in males (p = 0.53). Fasting lactate and HOMA-IR increased in males (p = 0.01 and p = 0.02, respectively), but not females, following a three-day high-fat diet.
+
+ CONCLUSION: Indices of the metabolic syndrome associated with fasting plasma lactates in young relatively healthy individuals. Fasting lactate also increased in a sex-specific manner after a three-day high fat diet. Thus, lactate could become a clinical marker for metabolic disease risk. Copyright © 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 33X04XA5AT (Lactic Acid).
+Publication Type
+ Observational Study. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.dsx.2024.102955
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Broskey&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Fasting+plasma+lactate+as+a+possible+early+clinical+marker+for+metabolic+disease+risk.&volume=18&issue=2&spage=102955&epage=&date=2024&doi=10.1016%2Fj.dsx.2024.102955&pmid=38310736&sid=OVID:medline
+
+<87>
+Unique Identifier
+ 38124220
+Title
+ Impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care.
+Source
+ Thorax. 79(5):403-411, 2024 Apr 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Loewenthal L; Busby J; McDowell R; Brown T; Burhan H; Chaudhuri R; Dennison P; Dodd JW; Doe S; Faruqi S; Gore R; Idris E; Jackson DJ; Patel M; Pantin T; Pavord I; Pfeffer PE; Price DB; Rupani H; Siddiqui S; Heaney LG; Menzies-Gow A
+Author NameID
+ Loewenthal, Lola; ORCID: http://orcid.org/0000-0002-7368-9473
+ Busby, John; ORCID: http://orcid.org/0000-0003-4831-7464
+ Pavord, Ian; ORCID: http://orcid.org/0000-0002-4288-5973
+ Pfeffer, Paul E; ORCID: http://orcid.org/0000-0003-0369-2885
+ Price, David B; ORCID: http://orcid.org/0000-0002-9728-9992
+ Rupani, Hitasha; ORCID: http://orcid.org/0000-0002-0150-138X
+Corporate Author
+ UK Severe Asthma Registry
+Authors Full Name
+ Loewenthal, Lola; Busby, John; McDowell, Ronald; Brown, Thomas; Burhan, Hassan; Chaudhuri, Rekha; Dennison, Paddy; Dodd, James William; Doe, Simon; Faruqi, Shoaib; Gore, Robin; Idris, Elfatih; Jackson, David Joshua; Patel, Mitesh; Pantin, Thomas; Pavord, Ian; Pfeffer, Paul E; Price, David B; Rupani, Hitasha; Siddiqui, Salman; Heaney, Liam G; Menzies-Gow, Andrew.
+Institution
+ Loewenthal, Lola. National Lung and Heart Institute, Imperial College London, London, UK.
+ Loewenthal, Lola. Department of Asthma and Allergy, Department of Respiratory Medicine, Royal Brompton and Harefield Hospitals, London, UK.
+ Busby, John. Centre for Public Health, Queen's University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK.
+ McDowell, Ronald. Queen's University Belfast, Belfast, UK.
+ McDowell, Ronald. Ulster University, Coleraine, UK.
+ Brown, Thomas. Respiratory Medicine, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
+ Burhan, Hassan. Respiratory Department, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
+ Chaudhuri, Rekha. Respiratory Medicine, Gartnavel General Hospital, Glasgow, UK.
+ Chaudhuri, Rekha. University of Glasgow, Glasgow, UK.
+ Dennison, Paddy. Southampton NIHR Respiratory Biomedical Research Unit, Southampton University Hospitals NHS Trust, Southampton, UK.
+ Dodd, James William. Academic Respiratory Unit, University of Bristol, Bristol, UK.
+ Dodd, James William. North Bristol Lung Centre, North Bristol NHS Trust, Westbury on Trym, UK.
+ Doe, Simon. Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
+ Faruqi, Shoaib. Hull University Teaching Hospitals NHS Trust, Hull, UK.
+ Gore, Robin. Addenbrooke's Hospital, Cambridge, UK.
+ Idris, Elfatih. Royal Stoke University Hospital, Stoke-on-Trent, UK.
+ Jackson, David Joshua. Guy's Severe Asthma Centre, Guy's and St Thomas' Hospitals NHS Trust, London, UK.
+ Jackson, David Joshua. Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London Faculty of Life Sciences and Medicine, London, UK.
+ Patel, Mitesh. University Hospitals Plymouth, University Hospitals Plymouth NHS Trust, Plymouth, UK.
+ Pantin, Thomas. Respiratory Medicine, Manchester University NHS Foundation Trust, Manchester, UK.
+ Pavord, Ian. NIHR Respiratory BRC, Nuffield Department of Medicine, Oxford University, Oxford, UK.
+ Pfeffer, Paul E. St Bartholomew's Hospital, London, UK.
+ Price, David B. Observational and Pragmatic Research Institute Pte Ltd, Singapore.
+ Price, David B. Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
+ Rupani, Hitasha. University Hospital Southampton NHS Foundation Trust, Southampton, UK.
+ Rupani, Hitasha. University of Southampton, Southampton, UK.
+ Siddiqui, Salman. National Lung and Heart Institute, Imperial College London, London, UK.
+ Heaney, Liam G. Centre of Infection and Immunity, Queen's University Belfast, Belfast, UK.
+ Menzies-Gow, Andrew. Royal Brompton and Harefield Hospitals, London, UK a.menzies-gow@rbht.nhs.uk.
+MeSH Subject Headings
+ Humans
+ Female
+ Male
+ Retrospective Studies
+ Cross-Sectional Studies
+ Asthma/dt [Drug Therapy]
+ Asthma/ep [Epidemiology]
+ *Asthma
+ Biomarkers
+ Obesity
+ United Kingdom/ep [Epidemiology]
+Keyword Heading
+ Asthma
+ Asthma Epidemiology
+ Asthma in primary care
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: After puberty, females are more likely to develop asthma and in a more severe form than males. The associations between asthma and sex are complex with multiple intrinsic and external factors.
+
+ AIM: To evaluate the sex differences in the characteristics and treatment of patients with severe asthma (SA) in a real-world setting.
+
+ METHODS: Demographic, clinical and treatment characteristics for patients with SA in the UK Severe Asthma Registry (UKSAR) and Optimum Patient Care Research Database (OPCRD) were retrospectively analysed by sex using univariable and multivariable logistic regression analyses adjusted for year, age and hospital/practice.
+
+ RESULTS: 3679 (60.9% female) patients from UKSAR and 18 369 patients (67.9% female) from OPCRD with SA were included. Females were more likely to be symptomatic with increased Asthma Control Questionnaire-6 (UKSAR adjusted OR (aOR) 1.14, 95% CI 1.09 to 1.18) and Royal College of Physicians-3 Question scores (OPCRD aOR 1.29, 95% CI 1.13 to 1.47). However, they had a higher forced expiratory volume in 1 second per cent (FEV1%) predicted (UKSAR 68.7% vs 64.8%, p<0.001) with no significant difference in peak expiratory flow. Type 2 biomarkers IgE (UKSAR 129 IU/mL vs 208 IU/mL, p<0.001) and FeNO (UKSAR 36ppb vs 46ppb, p<0.001) were lower in females with no significant difference in blood eosinophils or biological therapy. Females were less likely to be on maintenance oral corticosteroids (UKSAR aOR 0.86, 95% CI 0.75 to 0.99) but more likely to be obese (UKSAR aOR 1.67, 95% CI 145 to 1.93; OPCRD SA aOR 1.46, 95% CI 1.34 to 1.58).
+
+ CONCLUSIONS: Females had increased symptoms and were more likely to be obese despite higher FEV1% predicted and lower type 2 biomarkers with consistent and clinically important differences across both datasets. Copyright © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1136%2fthorax-2023-220512
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Loewenthal&issn=0040-6376&title=Thorax&atitle=Impact+of+sex+on+severe+asthma%3A+a+cross-sectional+retrospective+analysis+of+UK+primary+and+specialist+care.&volume=79&issue=5&spage=403&epage=411&date=2024&doi=10.1136%2Fthorax-2023-220512&pmid=38124220&sid=OVID:medline
+
+<88>
+Unique Identifier
+ 37738560
+Title
+ Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial.
+Source
+ Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 79(1), 2024 Jan 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Justice JN; Leng XI; LeBrasseur NK; Tchkonia T; Kirkland JL; Mitin N; Liu Y; Kritchevsky SB; Nicklas BJ; Ding J
+Author NameID
+ Justice, Jamie N; ORCID: https://orcid.org/0000-0003-2953-4404
+ Kritchevsky, Stephen B; ORCID: https://orcid.org/0000-0003-3336-6781
+Authors Full Name
+ Justice, Jamie N; Leng, Xiaoyan I; LeBrasseur, Nathan K; Tchkonia, Tamara; Kirkland, James L; Mitin, Natalia; Liu, Yongmei; Kritchevsky, Stephen B; Nicklas, Barbara J; Ding, Jingzhong.
+Institution
+ Justice, Jamie N. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ Justice, Jamie N. Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ Leng, Xiaoyan I. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ Leng, Xiaoyan I. Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ LeBrasseur, Nathan K. Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
+ LeBrasseur, Nathan K. Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
+ Tchkonia, Tamara. Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
+ Tchkonia, Tamara. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
+ Kirkland, James L. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
+ Kirkland, James L. Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
+ Mitin, Natalia. Sapere Bio, Triangle Research Park, North Carolina, USA.
+ Liu, Yongmei. Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
+ Kritchevsky, Stephen B. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ Kritchevsky, Stephen B. Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ Nicklas, Barbara J. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ Nicklas, Barbara J. Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ Ding, Jingzhong. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+ Ding, Jingzhong. Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
+MeSH Subject Headings
+ Female
+ Humans
+ Middle Aged
+ Aged
+ Male
+ *Caloric Restriction
+ *Prediabetic State
+ Secretome
+ Cyclin-Dependent Kinase Inhibitor p16/me [Metabolism]
+ Cellular Senescence
+ Biomarkers/me [Metabolism]
+ Obesity
+Keyword Heading
+ Aging
+ Biomarkers
+ Cell senescence
+ Dietary restriction
+ Inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cellular senescence is a biological aging process that is exacerbated by obesity and leads to inflammation and age- and obesogenic-driven chronic diseases including type 2 diabetes. Caloric restriction (CR) may improve metabolic function in part by reducing cellular senescence and the pro-inflammatory senescence-associated phenotype (SASP). We conducted an ancillary investigation of an 18-week randomized controlled trial (RCT) of CR (n = 31) or Control (n = 27) in 58 middle-aged/older adults (57.6 +/- 5.8 years; 75% Women) with obesity and prediabetes. We measured mRNA expression of select senescence and apoptosis genes in blood CD3 + T cells (qRT-PCR) and a panel of 25 plasma SASP proteins (Luminex/multiplex; ELISA). Participants randomized to CR lost -10.8 +/- 0.9 kg (-11.3% +/- 5.4%) over 18 weeks compared with +0.5 +/- 0.9 kg (+0.03% +/- 3.5%) in Control group. T-cell expression of senescence biomarkers, p16INK4a and p21CIP1/WAF1, and apoptosis markers, BCL2L1 and BAK1, was not different between CR and Control groups in age, race, and sex-adjusted mixed models (p > .05, all). Iterative principal axis factor analysis was used to develop composite SASP Factors, and the Factors comprising TNFRI, TNFRII, uPAR, MMP1, GDF15, OPN, Fas, and MPO were significantly altered with CR intervention (age, sex, race-adjusted mixed model time x treatment F = 4.17, p <= .05) and associated with the degree of weight loss (R2 = 0.12, p <= .05). Our study provides evidence from an RCT that specific circulating biomarkers of senescent cell burden are changed by CR in middle-aged and older adults with obesity and prediabetes. Future studies compare tissue and circulating levels of p16INK4a and pro-inflammatory SASP biomarkers in other populations, and interventions. Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Cyclin-Dependent Kinase Inhibitor p16). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1093%2fgerona%2fglad214
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Justice&issn=1079-5006&title=Journals+of+Gerontology+Series+A-Biological+Sciences+%26+Medical+Sciences&atitle=Caloric+Restriction+Intervention+Alters+Specific+Circulating+Biomarkers+of+the+Senescence-Associated+Secretome+in+Middle-Aged+and+Older+Adults+With+Obesity+and+Prediabetes+in+an+18-Week+Randomized+Controlled+Trial.&volume=79&issue=1&spage=&epage=&date=2024&doi=10.1093%2Fgerona%2Fglad214&pmid=37738560&sid=OVID:medline
+
+<89>
+Unique Identifier
+ 38316651
+Title
+ miRNA expression in PCOS: unveiling a paradigm shift toward biomarker discovery. [Review]
+Source
+ Archives of Gynecology & Obstetrics. 309(5):1707-1723, 2024 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rashid G; Khan NA; Elsori D; Youness RA; Hassan H; Siwan D; Seth N; Kamal MA; Rizvi S; Babker AM; Hafez W
+Author NameID
+ Rashid, Gowhar; ORCID: http://orcid.org/0000-0002-6321-3877
+Authors Full Name
+ Rashid, Gowhar; Khan, Nihad Ashraf; Elsori, Deena; Youness, Rana A; Hassan, Homa; Siwan, Deepali; Seth, Namrata; Kamal, Mohammad Azhar; Rizvi, Saliha; Babker, Asaad Ma; Hafez, Wael.
+Institution
+ Rashid, Gowhar. Department of Medical Lab Technology, Amity Medical School, Amity University Haryana, Gurugram, India. gowhar9@gmail.com.
+ Khan, Nihad Ashraf. Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia, Delhi, 110025, India.
+ Elsori, Deena. Rabdan Academy, Abu Dhabi, UAE.
+ Youness, Rana A. Biology and Biochemistry Department, Faculty of Biotechnology, German International University, Cairo, Egypt.
+ Hassan, Homa. Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
+ Siwan, Deepali. Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University, Delhi, 110017, India.
+ Seth, Namrata. Department of Biotechnology, Indian Institute of Science and Technology, Bhopal, 462066, India.
+ Kamal, Mohammad Azhar. Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
+ Rizvi, Saliha. Department of Biotechnology, Era University, Lucknow, India.
+ Babker, Asaad Ma. Department of Medical Laboratory Sciences, Gulf Medical University, Ajman, United Arab Emirates.
+ Hafez, Wael. The Medical Research Division, Department of Internal Medicine, the National Research Centre, Cairo, Egypt.
+MeSH Subject Headings
+ Humans
+ Female
+ Polycystic Ovary Syndrome/me [Metabolism]
+ *Polycystic Ovary Syndrome
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ Hyperandrogenism/ge [Genetics]
+ *Hyperandrogenism
+ Obesity/ge [Genetics]
+ Biomarkers
+Keyword Heading
+ Androgens
+ Biomarkers
+ Endocrine disorder
+ Follicular cells
+ Polycystic ovarian syndrome
+ Theca cells
+ miRNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects a substantial percentage of women, estimated at around 9-21%. This condition can lead to anovulatory infertility in women of childbearing age and is often accompanied by various metabolic disturbances, including hyperandrogenism, insulin resistance, obesity, type-2 diabetes, and elevated cholesterol levels. The development of PCOS is influenced by a combination of epigenetic alterations, genetic mutations, and changes in the expression of non-coding RNAs, particularly microRNAs (miRNAs). MicroRNAs, commonly referred to as non-coding RNAs, are approximately 22 nucleotides in length and primarily function in post-transcriptional gene regulation, facilitating mRNA degradation and repressing translation. Their dynamic expression in different cells and tissues contributes to the regulation of various biological and cellular pathways. As a result, they have become pivotal biomarkers for various diseases, including PCOS, demonstrating intricate associations with diverse health conditions. The aberrant expression of miRNAs has been detected in the serum of women with PCOS, with overexpression and dysregulation of these miRNAs playing a central role in the atypical expression of endocrine hormones linked to PCOS. This review takes a comprehensive approach to explore the upregulation and downregulation of various miRNAs present in ovarian follicular cells, granulosa cells, and theca cells of women diagnosed with PCOS. Furthermore, it discusses the potential for a theragnostic approach using miRNAs to better understand and manage PCOS. Copyright © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (MicroRNAs). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs00404-024-07379-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rashid&issn=0932-0067&title=Archives+of+Gynecology+%26+Obstetrics&atitle=miRNA+expression+in+PCOS%3A+unveiling+a+paradigm+shift+toward+biomarker+discovery.&volume=309&issue=5&spage=1707&epage=1723&date=2024&doi=10.1007%2Fs00404-024-07379-4&pmid=38316651&sid=OVID:medline
+
+<90>
+Unique Identifier
+ 37597533
+Title
+ Evaluation of cardiac autonomic function and low-grade inflammation in children with obesity living in the Northeast Brazilian region.
+Source
+ Jornal de Pediatria. 100(1):74-80, 2024 Jan-Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Costa PCT; de Souza JR; Lima PC; Duarte DB; Viana das Neves TAF; Pereira JKG; Silva-Luis CC; de Moraes RCS; Braga VA; de Souza EL; Martins VJB; de Brito Alves JL
+Authors Full Name
+ Costa, Paulo Cesar Trindade; de Souza, Joelma Rodrigues; Lima, Poliana Correia; Duarte, Davyson Barbosa; Viana das Neves, Thallyta Alanna Ferreira; Pereira, Joicy Karla Grangeiro; Silva-Luis, Cristiane Cosmo; de Moraes, Rubia Cartaxo Squizato; Braga, Valdir de Andrade; de Souza, Evandro Leite; Martins, Vinicius Jose Baccin; de Brito Alves, Jose Luiz.
+Institution
+ Costa, Paulo Cesar Trindade. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil.
+ de Souza, Joelma Rodrigues. Universidade Federal da Paraiba, Departamento de Fisiologia e Patologia, Joao Pessoa, PB, Brazil.
+ Lima, Poliana Correia. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil.
+ Duarte, Davyson Barbosa. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil.
+ Viana das Neves, Thallyta Alanna Ferreira. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil.
+ Pereira, Joicy Karla Grangeiro. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil.
+ Silva-Luis, Cristiane Cosmo. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil.
+ de Moraes, Rubia Cartaxo Squizato. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil.
+ Braga, Valdir de Andrade. Universidade Federal da Paraiba, Centro de Biotecnologia, Joao Pessoa, PB, Brazil.
+ de Souza, Evandro Leite. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil.
+ Martins, Vinicius Jose Baccin. Universidade Federal da Paraiba, Departamento de Fisiologia e Patologia, Joao Pessoa, PB, Brazil.
+ de Brito Alves, Jose Luiz. Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil. Electronic address: jose.luiz@academico.ufpb.br.
+MeSH Subject Headings
+ Child
+ Humans
+ Brazil/ep [Epidemiology]
+ Cross-Sectional Studies
+ *Interleukin-2
+ *Obesity
+ Inflammation
+ Heart Rate/ph [Physiology]
+ Biomarkers
+Keyword Heading
+ Children
+ Cytokines
+ Heart rate variability
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Evaluate autonomic function and low-grade inflammation and characterize the correlation between these variables in schoolchildren with obesity living in the Brazilian northeast region.
+
+ METHODS: 84 children with obesity and 41 with normal weight were included in this cross-sectional study. Anthropometry, body composition, blood pressure (BP), inflammatory biomarkers, and heart rate variability (HRV) indexes were analyzed in children aged 7 to 11 years.
+
+ RESULTS: children with obesity had increased systolic (p = 0.0017) and diastolic (p = 0.0131) BP and heart rate (p = 0.0022). The children with obesity displayed significantly lower SDNN, RMSSD, NN50, HF (ms), HF (nu), SD1, SD2, and higher LF (ms), LF (nu), LF/HF, SD1/SD2, DFA-alpha1, and DFA-alpha2, compared to normal weight. A lower and higher capacity for producing IL-10 (p = 0.039) and IL-2 (p = 0.009), respectively, were found in children with obesity compared to children with normal weight. Although IL-2, IL-4 and IL17A did not correlate with HRV parameters, IL-6 was positively correlated with SDNN, LF (ms) and SD2, TNF-alpha was positively correlated with LF/HF and SD1/SD2 ratio, and IFN-gamma was positively correlated with SDNN, RMMSSD, NN50, LF (ms), HF (ms), SD1, and SD2.
+
+ CONCLUSIONS: The findings suggest that children with obesity have impaired autonomic function and systemic low-grade inflammation compared to children within the normal weight range, the inflammatory biomarkers were correlated with HRV parameters in schoolchildren living in the northeastern region of Brazil. Copyright © 2023 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Interleukin-2). 0 (Biomarkers).
+Rare Disease Supplementary Concept
+ Syndactyly, Type I
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.jped.2023.07.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Costa&issn=0021-7557&title=Jornal+de+Pediatria&atitle=Evaluation+of+cardiac+autonomic+function+and+low-grade+inflammation+in+children+with+obesity+living+in+the+Northeast+Brazilian+region.&volume=100&issue=1&spage=74&epage=80&date=2024&doi=10.1016%2Fj.jped.2023.07.003&pmid=37597533&sid=OVID:medline
+
+<91>
+Unique Identifier
+ 38381399
+Title
+ Relationship between serum beta-hydroxybutyrate and hepatic fatty acid oxidation in individuals with obesity and NAFLD.
+Source
+ American Journal of Physiology - Endocrinology & Metabolism. 326(4):E493-E502, 2024 Apr 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moore MP; Shryack G; Alessi I; Wieschhaus N; Meers GM; Johnson SA; Wheeler AA; Ibdah JA; Parks EJ; Rector RS
+Author NameID
+ Wheeler, Andrew A; ORCID: https://orcid.org/0000-0002-8675-887X
+ Parks, Elizabeth J; ORCID: https://orcid.org/0000-0001-5681-1097
+ Rector, R Scott; ORCID: https://orcid.org/0000-0001-9908-7123
+Authors Full Name
+ Moore, Mary P; Shryack, Grace; Alessi, Isabella; Wieschhaus, Nicole; Meers, Grace M; Johnson, Sarah A; Wheeler, Andrew A; Ibdah, Jamal A; Parks, Elizabeth J; Rector, R Scott.
+Institution
+ Moore, Mary P. Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, Missouri, United States.
+ Moore, Mary P. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
+ Shryack, Grace. Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, Missouri, United States.
+ Shryack, Grace. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
+ Shryack, Grace. NextGen Precision Health, Columbia, Missouri, United States.
+ Alessi, Isabella. Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, Missouri, United States.
+ Alessi, Isabella. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
+ Alessi, Isabella. NextGen Precision Health, Columbia, Missouri, United States.
+ Wieschhaus, Nicole. Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, Missouri, United States.
+ Wieschhaus, Nicole. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
+ Wieschhaus, Nicole. NextGen Precision Health, Columbia, Missouri, United States.
+ Meers, Grace M. Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, Missouri, United States.
+ Meers, Grace M. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
+ Meers, Grace M. NextGen Precision Health, Columbia, Missouri, United States.
+ Johnson, Sarah A. Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, Missouri, United States.
+ Johnson, Sarah A. Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, Missouri, United States.
+ Wheeler, Andrew A. Department of Surgery, University of Missouri, Columbia, Missouri, United States.
+ Ibdah, Jamal A. Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, Missouri, United States.
+ Ibdah, Jamal A. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
+ Ibdah, Jamal A. Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, Missouri, United States.
+ Parks, Elizabeth J. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
+ Parks, Elizabeth J. NextGen Precision Health, Columbia, Missouri, United States.
+ Parks, Elizabeth J. Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, Missouri, United States.
+ Rector, R Scott. Research Service, Harry S Truman Memorial Veterans Medical Center, Columbia, Missouri, United States.
+ Rector, R Scott. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
+ Rector, R Scott. NextGen Precision Health, Columbia, Missouri, United States.
+ Rector, R Scott. Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, Missouri, United States.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ 3-Hydroxybutyric Acid/me [Metabolism]
+ Liver/me [Metabolism]
+ Obesity/me [Metabolism]
+ Ketone Bodies/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ RNA, Messenger/me [Metabolism]
+ Palmitates/me [Metabolism]
+Keyword Heading
+ HMGCS2
+ MASLD
+ ketones
+ liver
+ mitochondria
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) is characterized by excess lipid accumulation that can progress to inflammation (nonalcoholic steatohepatitis, NASH), and fibrosis. Serum beta-hydroxybutyrate (beta-HB), a product of the ketogenic pathway, is commonly used as a surrogate marker for hepatic fatty acid oxidation (FAO). However, it remains uncertain whether this relationship holds true in the context of NAFLD in humans. We compared fasting serum beta-HB levels with direct measurement of liver mitochondrial palmitate oxidation in humans stratified based on NAFLD severity (n = 142). Patients were stratified based on NAFLD activity score (NAS): NAS = 0 (no disease), NAS = 1-2 (mild), NAS = 3-4 (moderate), and NAS >= 5 (advanced). Moderate and advanced NAFLD is associated with reductions in liver 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), serum beta-HB, but not 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL) mRNA, relative to no disease. Worsening liver mitochondrial complete palmitate oxidation corresponded with lower HMGCS2 mRNA but not total (complete + incomplete) palmitate oxidation. Interestingly, we found that liver HMGCS2 mRNA and serum beta-HB correlated with liver mitochondrial beta-hydroxyacyl-CoA dehydrogenase (beta-HAD) activity and CPT1A mRNA. Also, lower mitochondrial mass and markers of mitochondrial turnover positively correlated with lower HMGCS2 in the liver. These data suggest that liver ketogenesis and FAO occur at comparable rates in individuals with NAFLD. Our findings support the utility of serum beta-HB to serve as a marker of liver injury and hepatic FAO in the context of NAFLD. NEW & NOTEWORTHY Serum beta-hydroxybutyrate (beta-HB) is frequently utilized as a surrogate marker for hepatic fatty acid oxidation; however, few studies have investigated this relationship during states of liver disease. We found that the progression of nonalcoholic fatty liver disease (NAFLD) is associated with reductions in circulating beta-HB and liver 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2). As well, decreased rates of hepatic fatty acid oxidation correlated with liver HMGCS2 mRNA and serum beta-HB. Our work supports serum beta-HB as a potential marker for hepatic fatty acid oxidation and liver injury during NAFLD.
+Registry Number/Name of Substance
+ TZP1275679 (3-Hydroxybutyric Acid). 0 (Ketone Bodies). 0 (Biomarkers). 0 (RNA, Messenger). 0 (Palmitates).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1152%2fajpendo.00336.2023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moore&issn=0193-1849&title=American+Journal+of+Physiology+-+Endocrinology+%26+Metabolism&atitle=Relationship+between+serum+beta-hydroxybutyrate+and+hepatic+fatty+acid+oxidation+in+individuals+with+obesity+and+NAFLD.&volume=326&issue=4&spage=E493&epage=E502&date=2024&doi=10.1152%2Fajpendo.00336.2023&pmid=38381399&sid=OVID:medline
+
+<92>
+Unique Identifier
+ 37981526
+Title
+ Muscularity and adiposity are differently associated with inflammatory and nutritional biomarkers among patients on hemodialysis and peritoneal dialysis.
+Source
+ European Journal of Internal Medicine. 122:109-112, 2024 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Molfino A; Imbimbo G; Picconi O; Tartaglione L; Amabile MI; Lai S
+Authors Full Name
+ Molfino, Alessio; Imbimbo, Giovanni; Picconi, Orietta; Tartaglione, Lida; Amabile, Maria Ida; Lai, Silvia.
+Institution
+ Molfino, Alessio. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy. Electronic address: alessio.molfino@uniroma1.it.
+ Imbimbo, Giovanni. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
+ Picconi, Orietta. National HIV/AIDS Center, Istituto Superiore di Sanita, Rome, Italy.
+ Tartaglione, Lida. Division of Nephrology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
+ Amabile, Maria Ida. Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
+ Lai, Silvia. Division of Nephrology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
+MeSH Subject Headings
+ Humans
+ *Adiposity
+ Renal Dialysis
+ *Peritoneal Dialysis
+ Obesity
+ Body Composition
+ Biomarkers
+ C-Reactive Protein
+ Water
+Keyword Heading
+ Adiposity
+ Dialysis
+ Muscle
+ NLR
+ Nutrition-inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Nutritional alterations are prevalent in patients undergoing hemodialysis (HD) and peritoneal dialysis (PD). We aimed at evaluating whether body composition parameters in HD vs PD are differently associated with nutritional and inflammatory biomarkers.
+
+ METHODS: Body composition was assessed by bioimpedance analysis. Neutrophil to lymphocyte ratio (NLR), serum albumin and C-reactive protein were used as nutritional and inflammatory biomarkers. Multivariable linear regression analysis was used to determine association(s) of body composition parameters with biomarkers.
+
+ RESULTS: We enrolled a total of 108 patients, 58 on HD and 50 on PD. Fat free mass percent was higher in HD patients than PD (p = 0.006) and higher extracellular water (ECW)/intracellular water (ICW) in HD compared to PD patients (p = 0.023), as well as fat mass index was greater in PD than HD (p = 0.004). In HD patients, albumin positively correlated with fat free mass (r = 0.42; p = 0.001) and ICW/h2 (r = 0.31; p = 0.02). In PD, NLR positively correlated with fat mass (r = 0.36; p = 0.01), fat mass index (r = 0.37; p = 0.01) and ECW (r = 0.41; p = 0.005), and negatively correlated with fat free mass percent (r = -0.30; p = 0.04) and ICW percent (r = -0.34; p = 0.02). By linear regression analysis, in HD fat free mass index was associated with albumin and the absence of diabetes. In PD, the association of fat free mass index was present with NLR. Regarding adiposity, in HD we found no association of ECW/ICW with NLR and CRP, whereas in PD the ECW/ICW was associated with NLR.
+
+ CONCLUSION: Inflammation drives body composition changes with differences according to the type of dialysis, as expressed by the modulation of some circulating biomarkers. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). 059QF0KO0R (Water).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.ejim.2023.11.015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Molfino&issn=0953-6205&title=European+Journal+of+Internal+Medicine&atitle=Muscularity+and+adiposity+are+differently+associated+with+inflammatory+and+nutritional+biomarkers+among+patients+on+hemodialysis+and+peritoneal+dialysis.&volume=122&issue=&spage=109&epage=112&date=2024&doi=10.1016%2Fj.ejim.2023.11.015&pmid=37981526&sid=OVID:medline
+
+<93>
+Unique Identifier
+ 38458803
+Title
+ Multicomponent (bio)markers for obesity risk prediction: a scoping review protocol.
+Source
+ BMJ Open. 14(3):e083558, 2024 Mar 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vahid F; Dessenne C; Tur JA; Bouzas C; Devaux Y; Malisoux L; Monserrat-Mesquida M; Sureda A; Desai MS; Turner JD; Lamy E; Perez-Jimenez M; Ravn-Haren G; Andersen R; Forberger S; Nagrani R; Ouzzahra Y; Fontefrancesco MF; Onorati MG; Bonetti GG; de-Magistris T; Bohn T
+Author NameID
+ Vahid, Farhad; ORCID: http://orcid.org/0000-0002-7380-3790
+ Dessenne, Coralie; ORCID: http://orcid.org/0000-0001-7723-0304
+ Tur, Josep A; ORCID: http://orcid.org/0000-0002-6940-0761
+ Bouzas, Cristina; ORCID: http://orcid.org/0000-0002-1407-8461
+ Devaux, Yvan; ORCID: http://orcid.org/0000-0002-5321-8543
+ Malisoux, Laurent; ORCID: http://orcid.org/0000-0002-6601-5630
+ Monserrat-Mesquida, Margalida; ORCID: http://orcid.org/0000-0002-8856-135X
+ Sureda, Antoni; ORCID: http://orcid.org/0000-0001-8656-6838
+ Desai, Mahesh S; ORCID: http://orcid.org/0000-0002-9223-2209
+ Turner, Jonathan D; ORCID: http://orcid.org/0000-0002-2760-1071
+ Lamy, Elsa; ORCID: http://orcid.org/0000-0002-9370-1337
+ Perez-Jimenez, Maria; ORCID: http://orcid.org/0000-0003-3143-4058
+ Ravn-Haren, Gitte; ORCID: http://orcid.org/0000-0002-4587-089X
+ Andersen, Rikke; ORCID: http://orcid.org/0000-0002-5091-6995
+ Forberger, Sarah; ORCID: http://orcid.org/0000-0002-7169-675X
+ Nagrani, Rajini; ORCID: http://orcid.org/0000-0002-1708-2319
+ Fontefrancesco, Michele Filippo; ORCID: http://orcid.org/0000-0003-3247-6110
+ Onorati, Maria Giovanna; ORCID: http://orcid.org/0000-0003-1847-0230
+ de-Magistris, Tiziana; ORCID: http://orcid.org/0000-0001-5480-183X
+ Bohn, Torsten; ORCID: http://orcid.org/0000-0002-7825-0697
+Authors Full Name
+ Vahid, Farhad; Dessenne, Coralie; Tur, Josep A; Bouzas, Cristina; Devaux, Yvan; Malisoux, Laurent; Monserrat-Mesquida, Margalida; Sureda, Antoni; Desai, Mahesh S; Turner, Jonathan D; Lamy, Elsa; Perez-Jimenez, Maria; Ravn-Haren, Gitte; Andersen, Rikke; Forberger, Sarah; Nagrani, Rajini; Ouzzahra, Yacine; Fontefrancesco, Michele Filippo; Onorati, Maria Giovanna; Bonetti, Gino Gabriel; de-Magistris, Tiziana; Bohn, Torsten.
+Institution
+ Vahid, Farhad. Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.
+ Dessenne, Coralie. Science Office, Luxembourg Institute of Health, Strassen, Luxembourg.
+ Tur, Josep A. Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, IdISBa & CIBEROBN (ISCIII), Palma de Mallorca, Spain.
+ Bouzas, Cristina. Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, IdISBa & CIBEROBN (ISCIII), Palma de Mallorca, Spain.
+ Devaux, Yvan. Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.
+ Malisoux, Laurent. Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.
+ Monserrat-Mesquida, Margalida. Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, IdISBa & CIBEROBN (ISCIII), Palma de Mallorca, Spain.
+ Sureda, Antoni. Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, IdISBa & CIBEROBN (ISCIII), Palma de Mallorca, Spain.
+ Desai, Mahesh S. Department of Infection and Immunity, Luxembourg Institute of Health, Esch sur Alzette, Luxembourg.
+ Turner, Jonathan D. Department of Infection and Immunity, Luxembourg Institute of Health, Esch sur Alzette, Luxembourg.
+ Lamy, Elsa. MED-Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability InstituteUniversity of Evora, Evora, Portugal, Evora, Portugal.
+ Perez-Jimenez, Maria. MED-Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability InstituteUniversity of Evora, Evora, Portugal, Evora, Portugal.
+ Ravn-Haren, Gitte. Technical University of Denmark, Kongens Lyngby, Denmark.
+ Andersen, Rikke. Technical University of Denmark, Kongens Lyngby, Denmark.
+ Forberger, Sarah. Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
+ Nagrani, Rajini. Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
+ Ouzzahra, Yacine. Science Office, Luxembourg Institute of Health, Strassen, Luxembourg.
+ Fontefrancesco, Michele Filippo. University of Gastronomic Sciences, Pollenzo, Italy.
+ Onorati, Maria Giovanna. University of Gastronomic Sciences, Pollenzo, Italy.
+ Bonetti, Gino Gabriel. University of Gastronomic Sciences, Pollenzo, Italy.
+ de-Magistris, Tiziana. Centro de Investigacion y Tecnologia Agroalimentaria de Aragon, Zaragoza, Spain.
+ Bohn, Torsten. Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg torsten.bohn@gmx.ch.
+MeSH Subject Headings
+ Humans
+ Anthropometry
+ *Biomarkers
+ Databases, Factual
+ Obesity/di [Diagnosis]
+ *Obesity
+ Research Design
+ Review Literature as Topic
+Keyword Heading
+ Behavior
+ Obesity
+ PUBLIC HEALTH
+ Primary Prevention
+ Quality of Life
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Despite international efforts, the number of individuals struggling with obesity is still increasing. An important aspect of obesity prevention relates to identifying individuals at risk at early stage, allowing for timely risk stratification and initiation of countermeasures. However, obesity is complex and multifactorial by nature, and one isolated (bio)marker is unlikely to enable an optimal risk stratification and prognosis for the individual; rather, a combined set is required. Such a multicomponent interpretation would integrate biomarkers from various domains, such as classical markers (eg, anthropometrics, blood lipids), multiomics (eg, genetics, proteomics, metabolomics), lifestyle and behavioural attributes (eg, diet, physical activity, sleep patterns), psychological traits (mental health status such as depression) and additional host factors (eg, gut microbiota diversity), also by means of advanced interpretation tools such as machine learning. In this paper, we will present a protocol that will be employed for a scoping review that attempts to summarise and map the state-of-the-art in the area of multicomponent (bio)markers related to obesity, focusing on the usability and effectiveness of such biomarkers.
+
+ METHODS AND ANALYSIS: PubMed, Scopus, CINAHL and Embase databases will be searched using predefined key terms to identify peer-reviewed articles published in English until January 2024. Once downloaded into EndNote for deduplication, CADIMA will be employed to review and select abstracts and full-text articles in a two-step procedure, by two independent reviewers. Data extraction will then be carried out by several independent reviewers. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews and Peer Review of Electronic Search Strategies guidelines will be followed. Combinations employing at least two biomarkers from different domains will be mapped and discussed.
+
+ ETHICS AND DISSEMINATION: Ethical approval is not required; data will rely on published articles. Findings will be published open access in an international peer-reviewed journal. This review will allow guiding future directions for research and public health strategies on obesity prevention, paving the way towards multicomponent interventions. Copyright © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1136%2fbmjopen-2023-083558
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vahid&issn=2044-6055&title=BMJ+Open&atitle=Multicomponent+%28bio%29markers+for+obesity+risk+prediction%3A+a+scoping+review+protocol.&volume=14&issue=3&spage=e083558&epage=&date=2024&doi=10.1136%2Fbmjopen-2023-083558&pmid=38458803&sid=OVID:medline
+
+<94>
+Unique Identifier
+ 38562410
+Title
+ Salivary alpha-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women.
+Source
+ Frontiers in Endocrinology. 15:1348853, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al Akl NS; Khalifa O; Habibullah M; Arredouani A
+Authors Full Name
+ Al Akl, Neyla S; Khalifa, Olfa; Habibullah, Mohammad; Arredouani, Abdelilah.
+Institution
+ Al Akl, Neyla S. Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.
+ Khalifa, Olfa. Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.
+ Habibullah, Mohammad. College of Medicine, Qatar University, Doha, Qatar.
+ Arredouani, Abdelilah. Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.
+ Arredouani, Abdelilah. College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.
+MeSH Subject Headings
+ Male
+ Adult
+ Child
+ Humans
+ Female
+ Middle Aged
+ Overweight
+ *Salivary alpha-Amylases
+ Adiponectin
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases
+ Obesity/me [Metabolism]
+ Biomarkers
+ Inflammation/me [Metabolism]
+ Cytokines
+Keyword Heading
+ cardiometabolic risk
+ cardiovascular disease
+ inflammation
+ obesity
+ salivary alpha-amylase activity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction: Obesity, prevalent in approximately 80% of Qatar's adult population, increases the risk of complications like type 2 diabetes and cardiovascular diseases. Predictive biomarkers are crucial for preventive strategies. Salivary alpha-amylase activity (sAAa) inversely correlates with obesity and insulin resistance in adults and children. However, the connection between sAAa and cardiometabolic risk factors or chronic low-grade inflammation markers remains unclear. This study explores the association between serum sAAa and adiposity markers related to cardiovascular diseases, as well as markers indicative of chronic low-grade inflammation.
+
+ Methods: Serum samples and clinical data of 1500 adult, non-diabetic, Overweight/Obese participants were obtained from Qatar Biobank (QBB). We quantified sAAa and C reactive protein (CRP) levels with an autoanalyzer. Cytokines, adipokines, and adiponectin of a subset of 228 samples were quantified using a bead-based multiplex assay. The associations between the sAAa and the adiposity indices and low-grade inflammatory protein CRP and multiple cytokines were assessed using Pearson's correlation and adjusted linear regression.
+
+ Results: The mean age of the participants was 36 +/- 10 years for both sexes of which 76.6% are women. Our analysis revealed a significant linear association between sAAa and adiposity-associated biomarkers, including body mass index beta -0.032 [95% CI -0.049 to -0.05], waist circumference beta -0.05 [95% CI -0.09 to -0.02], hip circumference beta -0.052 [95% CI -0.087 to -0.017], and HDL beta 0.002 [95% CI 0.001 to 0.004], albeit only in women. Additionally, sAAa demonstrated a significant positive association with adiponectin beta 0.007 [95% CI 0.001 to 0.01]while concurrently displaying significant negative associations with CRP beta -0.02 [95% CI -0.044 to -0.0001], TNF-alpha beta -0.105 [95% CI -0.207 to -0.004], IL-6 beta [95% CI -0.39 -0.75 to -0.04], and ghrelin beta -5.95 [95% CI -11.71 to -0.20], specifically within the female population.
+
+ Conclusion: Our findings delineate significant associations between sAAa and markers indicative of cardiovascular disease risk and inflammation among overweight/obese adult Qatari females. Subsequent investigations are warranted to elucidate the nuances of these gender-specific associations comprehensively. Copyright © 2024 Al Akl, Khalifa, Habibullah and Arredouani.
+Registry Number/Name of Substance
+ EC 3-2-1-1 (Salivary alpha-Amylases). 0 (Adiponectin). 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3389%2ffendo.2024.1348853
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al+Akl&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Salivary+alpha-amylase+activity+is+associated+with+cardiometabolic+and+inflammatory+biomarkers+in+overweight%2Fobese%2C+non-diabetic+Qatari+women.&volume=15&issue=&spage=1348853&epage=&date=2024&doi=10.3389%2Ffendo.2024.1348853&pmid=38562410&sid=OVID:medline
+
+<95>
+Unique Identifier
+ 38538346
+Title
+ The Relationship between Mitochondrial Genome Mutations in Monocytes and the Development of Obesity and Coronary Heart Disease.
+Source
+ Frontiers in Bioscience. 16(1):6, 2024 Mar 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tolstik TV; Kirichenko TV; Bogatyreva AI; Markina YV; Kalmykov VA; Markin AM
+Authors Full Name
+ Tolstik, Taisiya V; Kirichenko, Tatiana V; Bogatyreva, Anastasia I; Markina, Yuliya V; Kalmykov, Vladislav A; Markin, Alexander M.
+Institution
+ Tolstik, Taisiya V. Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
+ Kirichenko, Tatiana V. Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
+ Bogatyreva, Anastasia I. Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
+ Markina, Yuliya V. Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
+ Kalmykov, Vladislav A. Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
+ Markin, Alexander M. Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
+ Markin, Alexander M. Medical Institute, Peoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), 117198 Moscow, Russia.
+MeSH Subject Headings
+ Humans
+ Carotid Intima-Media Thickness
+ Monocytes
+ Genome, Mitochondrial/ge [Genetics]
+ *Genome, Mitochondrial
+ Coronary Disease/ge [Genetics]
+ *Coronary Disease
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Risk Factors
+ *Cardiovascular Diseases
+ Inflammation
+ Biomarkers
+ Mutation/ge [Genetics]
+ *Metabolic Diseases
+ DNA, Mitochondrial/ge [Genetics]
+ *Mitochondrial Diseases
+Keyword Heading
+ cardiovascular diseases
+ inflammation
+ mitochondria
+ monocytes
+ mtDNA mutations
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Metabolic disorders, including obesity, are often accompanied by an increased risk of cardiovascular complications. Monocytes are the common link between obesity and cardiovascular diseases (CVDs). The bias of innate cellular immunity towards pro-inflammatory activation stimulates the development of diseases associated with chronic inflammation, in particular metabolic disorders, including obesity, as well as CVDs. Disorders in the functional state of monocytes and activation of inflammation may be associated with mitochondrial dysfunction. Mutations accumulating in mitochondrial DNA with age may lead to mitochondrial dysfunction and may be considered a potential marker for developing chronic inflammatory diseases.
+
+ METHODS: The present study aimed to study the relationship between mitochondrial heteroplasmy in CD14+ monocytes and cardiovascular risk factors in 22 patients with obesity and coronary heart disease (CHD) by comparing them to 22 healthy subjects.
+
+ RESULTS: It was found that single-nucleotide variations (SNV) A11467G have a negative correlation with total cholesterol (r = -0.82, p < 0.05), low density lipoproteins (LDL) (r = -0.82, p < 0.05), with age (r = -0.57, p < 0.05) and with mean carotid intima-media thickness (cIMT) (r = -0.43, p < 0.05) and a positive correlation with HDL level (r = 0.71, p < 0.05). SNV 576insC positively correlated with body mass index (BMI) (r = 0.60, p < 0.001) and LDL level (r = 0.43, p < 0.05). SNV A1811G positively correlated with mean cIMT (r = 0.60, p < 0.05).
+
+ CONCLUSIONS: It was revealed that some variants of mitochondrial DNA (mtDNA) heteroplasmy are associated with CVD risk factors. The results demonstrate the potential for using these molecular genetic markers to develop personalized CVD and metabolic disorder treatments. Copyright © 2024 The Author(s). Published by IMR Press.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (DNA, Mitochondrial).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.31083%2fj.fbs1601006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tolstik&issn=1945-0516&title=Frontiers+in+Bioscience&atitle=The+Relationship+between+Mitochondrial+Genome+Mutations+in+Monocytes+and+the+Development+of+Obesity+and+Coronary+Heart+Disease.&volume=16&issue=1&spage=6&epage=&date=2024&doi=10.31083%2Fj.fbs1601006&pmid=38538346&sid=OVID:medline
+
+<96>
+Unique Identifier
+ 38529395
+Title
+ Clinical features of early-onset type 2 diabetes and its association with triglyceride glucose-body mass index: a cross-sectional study.
+Source
+ Frontiers in Endocrinology. 15:1356942, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jiang Y; Lai X
+Authors Full Name
+ Jiang, Yanjuan; Lai, Xiaoyang.
+Institution
+ Jiang, Yanjuan. The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
+ Lai, Xiaoyang. The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
+MeSH Subject Headings
+ Adult
+ Humans
+ Body Mass Index
+ Glucose
+ Cross-Sectional Studies
+ Blood Glucose/me [Metabolism]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Triglycerides
+ Uric Acid
+ Biomarkers
+ Obesity
+ *Insulin Resistance
+ Cholesterol, HDL
+Keyword Heading
+ early-onset type 2 diabetes
+ insulin resistance
+ obesity
+ overweight
+ triglyceride glucose-body mass index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: The incidence of early-onset type 2 diabetes (T2D) has increased significantly, with insulin resistance (IR) and obesity being the main drivers of its onset. This study aims to investigate the clinical characteristics of early-onset T2D and its association with triglyceride glucose body mass index (TyG-BMI), an emerging surrogate of IR.
+
+ Methods: A total of 1000 adults newly diagnosed with T2D were enrolled and divided into early-onset T2D (18~40 years, N=500) and late-onset T2D groups (>=40 years, N=500). Independent t and chi-squared tests were used to compare the characteristics of the two groups, and logistic regression analysis, trend tests, restricted cubic spline curves (RCSs), and receiver operating characteristic (ROC) curves were used to identify the relationship between TyG-BMI and early-onset T2D.
+
+ Results: Patients with early-onset T2D were more likely to have a higher body mass index (BMI), hemoglobin A1C (HbA1c), fasting plasma glucose (FPG), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), serum uric acid (SUA), triglyceride glucose index (TyG), and TyG-BMI (P < 0.05). A higher TyG-BMI was associated with an increased risk of early-onset T2D (P < 0.001). The RCSs showed a nonlinear relationship between TyG-BMI and early-onset T2D, and the slope of the curve increased with an increase in TyG-BMI (P for nonlinearity < 0.001). In the subgroup analysis, additive interactions between TyG-BMI and the risk of early-onset T2D were observed for sex, family history of diabetes, BMI, fatty liver, and hypertension (P < 0.001). ROC curve showed that the area under the curve of TyG-BMI was 0.6781, which was larger than its main components (TyG, BMI, FPG, TG). The best cutoff value was 254.865, the sensitivity was 74.6%, and the specificity was 53.6%.
+
+ Conclusion: Patients with early-onset T2D are characterized by severe IR, metabolic disorders, and being overweight/obese and an increase in TyG-BMI is independently associated with an increased risk of early-onset T2D. Copyright © 2024 Jiang and Lai.
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Blood Glucose). 0 (Triglycerides). 268B43MJ25 (Uric Acid). 0 (Biomarkers). 0 (Cholesterol, HDL).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3389%2ffendo.2024.1356942
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jiang&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Clinical+features+of+early-onset+type+2+diabetes+and+its+association+with+triglyceride+glucose-body+mass+index%3A+a+cross-sectional+study.&volume=15&issue=&spage=1356942&epage=&date=2024&doi=10.3389%2Ffendo.2024.1356942&pmid=38529395&sid=OVID:medline
+
+<97>
+Unique Identifier
+ 38078817
+Title
+ OBMeta: a comprehensive web server to analyze and validate gut microbial features and biomarkers for obesity-associated metabolic diseases.
+Source
+ Bioinformatics. 39(12), 2023 12 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xu C; Huang J; Gao Y; Zhao W; Shen Y; Luo F; Yu G; Zhu F; Ni Y
+Author NameID
+ Zhu, Feng; ORCID: https://orcid.org/0000-0001-8069-0053
+ Ni, Yan; ORCID: https://orcid.org/0000-0003-1779-7266
+Authors Full Name
+ Xu, Cuifang; Huang, Jiating; Gao, Yongqiang; Zhao, Weixing; Shen, Yiqi; Luo, Feihong; Yu, Gang; Zhu, Feng; Ni, Yan.
+Institution
+ Xu, Cuifang. Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhengjiang 310052, China.
+ Huang, Jiating. Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhengjiang 310052, China.
+ Huang, Jiating. Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, Zhengjiang 310058, China.
+ Gao, Yongqiang. Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhengjiang 310052, China.
+ Zhao, Weixing. Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhengjiang 310052, China.
+ Zhao, Weixing. Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, Zhengjiang 310058, China.
+ Shen, Yiqi. College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, Zhengjiang 310058, China.
+ Luo, Feihong. Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
+ Yu, Gang. Department of Data and Information, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhengjiang 310052, China.
+ Zhu, Feng. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhengjiang 310058, China.
+ Ni, Yan. Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhengjiang 310052, China.
+ Ni, Yan. Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, Zhengjiang 310058, China.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ *Gastrointestinal Microbiome
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2
+ Obesity/di [Diagnosis]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Metabolic Diseases/di [Diagnosis]
+ Metabolic Diseases/co [Complications]
+ *Metabolic Diseases
+ Biomarkers
+Abstract
+ MOTIVATION: Gut dysbiosis is closely associated with obesity and related metabolic diseases including type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). The gut microbial features and biomarkers have been increasingly investigated in many studies, which require further validation due to the limited sample size and various confounding factors that may affect microbial compositions in a single study. So far, it lacks a comprehensive bioinformatics pipeline providing automated statistical analysis and integrating multiple independent studies for cross-validation simultaneously.
+
+ RESULTS: OBMeta aims to streamline the standard metagenomics data analysis from diversity analysis, comparative analysis, and functional analysis to co-abundance network analysis. In addition, a curated database has been established with a total of 90 public research projects, covering three different phenotypes (Obesity, T2D, and NAFLD) and more than five different intervention strategies (exercise, diet, probiotics, medication, and surgery). With OBMeta, users can not only analyze their research projects but also search and match public datasets for cross-validation. Moreover, OBMeta provides cross-phenotype and cross-intervention-based advanced validation that maximally supports preliminary findings from an individual study. To summarize, OBMeta is a comprehensive web server to analyze and validate gut microbial features and biomarkers for obesity-associated metabolic diseases.
+
+ AVAILABILITY AND IMPLEMENTATION: OBMeta is freely available at: http://obmeta.met-bioinformatics.cn/. Copyright © The Author(s) 2023. Published by Oxford University Press.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1093%2fbioinformatics%2fbtad715
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xu&issn=1367-4803&title=Bioinformatics&atitle=OBMeta%3A+a+comprehensive+web+server+to+analyze+and+validate+gut+microbial+features+and+biomarkers+for+obesity-associated+metabolic+diseases.&volume=39&issue=12&spage=&epage=&date=2023&doi=10.1093%2Fbioinformatics%2Fbtad715&pmid=38078817&sid=OVID:medline
+
+<98>
+Unique Identifier
+ 38395746
+Title
+ Label-Free Electrochemical Immunosensor Based on Conjugated Polymer Film Coated Disposable Electrode for Ultrasensitive Determination of Resistin Potential Obesity Biomarker.
+Source
+ Acs Applied Bio Materials. 7(3):1820-1830, 2024 Mar 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aydin EB; Aydin M; Sezginturk MK
+Authors Full Name
+ Aydin, Elif Burcu; Aydin, Muhammet; Sezginturk, Mustafa Kemal.
+Institution
+ Aydin, Elif Burcu. Scientific and Technological Research Center, Tekirdag Namik Kemal University, Tekirdag, Turkey 59030.
+ Aydin, Muhammet. Scientific and Technological Research Center, Tekirdag Namik Kemal University, Tekirdag, Turkey 59030.
+ Sezginturk, Mustafa Kemal. Bioengineering Department, Faculty of Engineering, Canakkale Onsekiz Mart University, Canakkale, Turkey 17100.
+MeSH Subject Headings
+ Humans
+ *Resistin
+ *Biosensing Techniques
+ Immunoassay
+ Reproducibility of Results
+ Biomarkers
+ Electrodes
+ Obesity/di [Diagnosis]
+ Polymers
+Keyword Heading
+ conducting thiophene polymer
+ disposable biosensor
+ obesity biomarker
+ resistin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ A new label-free immunosensor was designed for sensitive detection of resistin obesity biomarker in human biological fluids. To construct a sensing interface, the monomer of double epoxy groups-substituted thiophene (TdiEpx) was synthesized for the fabrication of the biosensing system. A disposable indium tin oxide sheet was first modified by electrochemical polymerization of the TdiEpx monomer, and this robust and novel surface was characterized using different spectroscopic and electrochemical analyses. The double epoxy ends were linked to the amino ends of anti-resistin, and they served as binding points for the covalent binding of biomolecules. The double epoxy ends present in each TdiEpx monomer ensured an extensive surface area, which improved the quantity of attached anti-resistin. The determination of resistin antigen was based on the specific coupling of resistin with anti-resistin, and this interaction hindered the electron transfer reaction. The immunosensor introduced a wide linear range of 0.0125-15 pg/mL, a low detection limit of 4.17 fg/mL, and an excellent sensitivity of 1.38 kohm pg mL-1 cm2. In this study, a sandwich enzyme-linked immunosorbent assay spectrophotometric method was utilized as a reference technique for the quantitative analysis of resistin in human serum and saliva samples. Both measurements in clinical samples displayed correlations and high-correlation coefficients. In addition, this immunosensor had good storage stability, acceptable repeatability and reproducibility, high specificity, and good accuracy. The proposed immunosensor provided a simple and versatile impedimetric immunosensing platform and a promisingly sensitive way for clinical applications.
+Registry Number/Name of Substance
+ 0 (Resistin). 0 (Biomarkers). 0 (Polymers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1021%2facsabm.3c01231
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aydin&issn=2576-6422&title=Acs+Applied+Bio+Materials&atitle=Label-Free+Electrochemical+Immunosensor+Based+on+Conjugated+Polymer+Film+Coated+Disposable+Electrode+for+Ultrasensitive+Determination+of+Resistin+Potential+Obesity+Biomarker.&volume=7&issue=3&spage=1820&epage=1830&date=2024&doi=10.1021%2Facsabm.3c01231&pmid=38395746&sid=OVID:medline
+
+<99>
+Unique Identifier
+ 37857765
+Title
+ Prognosis of a malignant phenotype of obesity defined by a cardiac biomarker in hypertension: the Japan Morning Surge-Home Blood Pressure study.
+Source
+ Hypertension Research - Clinical & Experimental. 47(2):487-495, 2024 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Watanabe H; Hoshide S; Kanegae H; Kario K
+Authors Full Name
+ Watanabe, Hiroaki; Hoshide, Satoshi; Kanegae, Hisoshi; Kario, Kazuomi.
+Institution
+ Watanabe, Hiroaki. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
+ Hoshide, Satoshi. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
+ Kanegae, Hisoshi. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
+ Kanegae, Hisoshi. Genki Plaza Medical Center for Health Care, Tokyo, Japan.
+ Kario, Kazuomi. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan. kkario@jichi.ac.jp.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Humans
+ Japan/ep [Epidemiology]
+ Blood Pressure
+ Hypertension/co [Complications]
+ *Hypertension
+ Prognosis
+ Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases
+ Obesity/co [Complications]
+ Biomarkers
+ Phenotype
+ Peptide Fragments
+ Troponin T
+ Natriuretic Peptide, Brain
+Keyword Heading
+ Biomarkers
+ Cardiovascular event
+ High-sensitive cardiac troponin T
+ Hypertension
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity with increased high-sensitive cardiac troponin T (hs-cTnT) has been reported to be more likely to progress cardiovascular disease (CVD) events, which suggests that hs-cTnT may identify a "malignant" phenotype of obesity. We classified 3513 hypertensive patients from the Japan Morning Surge-Home Blood Pressure (J-HOP) study into groups based on body mass index (BMI) (normal weight: <25 kg/m2, overweight: 25-29.9 kg/m2, obesity: >=30 kg/m2) and elevations in biomarker levels (hs-cTnT >=3 ng/mL: 51.3%, 54.9%, 53.3%, and N-terminal pro-brain natriuretic peptide [NT-ProBNP] >=55 pg/mL: 51.1%, 40.7%, 36.0% in each BMI category). We evaluated the independent and combined associations of BMI and each hs-cTnT/NT-proBNP or both with CVD events (fatal and nonfatal coronary artery disease, stroke, and hospitalized heart failure). During the mean 6.4 +/- 3.9-year follow-up, 232 CVD events occurred. Obesity with elevated hs-cTnT was associated with a risk of CVD events compared to normal weight without elevated hs-cTnT (hazard ratio 3.22, 95% confidence interval: 1.83-5.68). A similar pattern of results was also observed across the status of obesity and elevated NT-proBNP. There was a significant interaction between hs-cTnT and CVD events according to the obesity status (p = 0.039), while this association was marginal in NT-proBNP (p = 0.060). The magnitude of the mediation of hs-cTnT for the association between obesity and CVD risk was 41.2%, and that for NT-proBNP was 8.1%. In this Japanese hypertensive population, the elevation of hs-cTnT identified obese patients at particularly high risk for developing CVD events, suggesting that hs-cTnT may identify a 'malignant' phenotype of obesity. Copyright © 2023. The Author(s), under exclusive licence to The Japanese Society of Hypertension.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (Troponin T). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1038%2fs41440-023-01468-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Watanabe&issn=0916-9636&title=Hypertension+Research+-+Clinical+%26+Experimental&atitle=Prognosis+of+a+malignant+phenotype+of+obesity+defined+by+a+cardiac+biomarker+in+hypertension%3A+the+Japan+Morning+Surge-Home+Blood+Pressure+study.&volume=47&issue=2&spage=487&epage=495&date=2024&doi=10.1038%2Fs41440-023-01468-8&pmid=37857765&sid=OVID:medline
+
+<100>
+Unique Identifier
+ 38421203
+Title
+ New aspects characterizing non-obese NAFLD by the analysis of the intestinal flora and metabolites using a mouse model.
+Source
+ Msystems. 9(3):e0102723, 2024 Mar 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang W; Cheng W; Li J; Huang Z; Lin H; Zhang W
+Author NameID
+ Zhang, Wenji; ORCID: https://orcid.org/0000-0003-1500-6627
+ Lin, Hui; ORCID: https://orcid.org/0000-0001-9785-2098
+ Zhang, Wenjuan; ORCID: https://orcid.org/0000-0003-2922-0640
+Authors Full Name
+ Zhang, Wenji; Cheng, Wenli; Li, JingHui; Huang, Zhenrui; Lin, Hui; Zhang, Wenjuan.
+Institution
+ Zhang, Wenji. Guangdong Provincial Engineering and Technology Research Center for Tobacco Breeding and Comprehensive Utilization, Key Laboratory of Crop Genetic Improvement of Guangdong Province, Crops Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
+ Cheng, Wenli. Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
+ Cheng, Wenli. Department of Radiation Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
+ Li, JingHui. Ningbo Psychiatric Hospital, Ningbo, China.
+ Huang, Zhenrui. Guangdong Provincial Engineering and Technology Research Center for Tobacco Breeding and Comprehensive Utilization, Key Laboratory of Crop Genetic Improvement of Guangdong Province, Crops Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
+ Lin, Hui. Department of Radiation Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
+ Zhang, Wenjuan. Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
+MeSH Subject Headings
+ Humans
+ Animals
+ Mice
+ Male
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ *Non-alcoholic Fatty Liver Disease
+ Gastrointestinal Microbiome/ge [Genetics]
+ *Gastrointestinal Microbiome
+ *Pantetheine/aa [Analogs & Derivatives]
+ Mice, Inbred C57BL
+ Obesity/co [Complications]
+ Biomarkers
+ Choline
+ Phosphates
+ *Firmicutes
+ *Bifidobacterium
+ *Tyramine/aa [Analogs & Derivatives]
+Keyword Heading
+ fecal metabolomics
+ intestinal flora
+ non-obese non-alcoholic fatty liver disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Non-alcoholic fatty liver disease (NAFLD) is a major public health problem due to the high incidence affecting approximately one-third of the world's population. NAFLD is usually linked to obesity and excessive weight. A subset of patients with NAFLD expresses normal or low body mass index; thus, the condition is called non-obese NAFLD or lean NAFLD. However, patients and healthcare professionals have little awareness and understanding of NAFLD in non-obese individuals. Furthermore, preclinical results from non-obese animal models with NAFLD are unclear. Gut microbiota and their metabolites in non-obese/lean-NAFLD patients differ from those in obese NAFLD patients. Therefore, we analyzed the biochemical indices, intestinal flora, and intestinal metabolites in a non-obese NAFLD mouse model established using a methionine-choline-deficient (MCD) diet. The significantly lean MCD mice had a remarkable fatty liver with lower serum triglyceride and free fatty acid levels, as well as higher alanine transaminase and aspartate transaminase levels than normal mice. 16S RNA sequencing of fecal DNA showed that the overall richness and diversity of the intestinal flora decreased in MCD mice, whereas the Firmicutes:Bacteroidota ratio was increased. g_Tuzzerella, s_Bifidobacterium pseudolongum, and s_Faecalibaculum rodentium were the predominant species in non-obese NAFLD mice. Fecal metabolomics using liquid chromatography-tandem mass spectrometry revealed the potential biomarkers for the prognosis and diagnosis of non-obese NAFLD, including high levels of tyramine glucuronide, 9,12,13-TriHOME, and pantetheine 4'-phosphate, and low levels of 3-carbamoyl-2-phenylpropionaldehyde, N-succinyl-L,L-2,6-diaminopimelate, 4-methyl-5-thiazoleethanol, homogentisic acid, and estriol. Our findings could be useful to identify and develop drugs to treat non-obese NAFLD and lean NAFLD.
+
+ IMPORTANCE: Patients and healthcare professionals have little awareness and understanding of NAFLD in non-obese individuals. In fact, about 40% of people with NAFLD worldwide are non-obese, and nearly one-fifth are lean. Lean NAFLD unfortunately may be unnoticed for years and remains undetected until hepatic damage is advanced and the prognosis is compromised. This study focused on the lean NAFLD, screened therapeutic agents, and biomarkers for the prognosis and diagnosis using MCD-induced male C57BL/6J mice. The metabolites tyramine glucuronide, 9,12,13-TriHOME, and pantetheine 4'-phosphate, together with the predominant flora including g_Tuzzerella, s_Bifidobacterium pseudolongum, and s_Faecalibaculum rodentium, were specific in non-obese NAFLD mice and might be used as targets for non-obese NAFLD drug exploration. This study is particularly significant for non-obese NAFLDs that need to be more actively noticed and vigilant.
+Registry Number/Name of Substance
+ 27972-85-6 (tyramine glucuronide). NM39WU8OFM (4'-phosphopantetheine). 496-65-1 (Pantetheine). 0 (Biomarkers). N91BDP6H0X (Choline). 0 (Phosphates). X8ZC7V0OX3 (Tyramine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1128%2fmsystems.01027-23
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=2379-5077&title=Msystems&atitle=New+aspects+characterizing+non-obese+NAFLD+by+the+analysis+of+the+intestinal+flora+and+metabolites+using+a+mouse+model.&volume=9&issue=3&spage=e0102723&epage=&date=2024&doi=10.1128%2Fmsystems.01027-23&pmid=38421203&sid=OVID:medline
+
+<101>
+Unique Identifier
+ 38289144
+Title
+ Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children.
+Source
+ Archives of Endocrinology & Metabolism. 68:e220353, 2024 Jan 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bravo C; Mericq V; Pereira A; Corvalan C; Tobar HE; Miranda JP; Santos JL
+Authors Full Name
+ Bravo, Carolina; Mericq, Veronica; Pereira, Ana; Corvalan, Camila; Tobar, Hugo E; Miranda, Jose Patricio; Santos, Jose Luis.
+Institution
+ Bravo, Carolina. Departamento de Nutricion, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Bravo, Carolina. Instituto de Nutricion y Tecnologia de Alimentos, Universidad de Chile, Santiago, Chile.
+ Mericq, Veronica. Instituto de Investigaciones MaternoInfantil, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
+ Pereira, Ana. Instituto de Nutricion y Tecnologia de Alimentos, Universidad de Chile, Santiago, Chile.
+ Corvalan, Camila. Instituto de Nutricion y Tecnologia de Alimentos, Universidad de Chile, Santiago, Chile.
+ Tobar, Hugo E. Departamento de Nutricion, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Miranda, Jose Patricio. Departamento de Nutricion, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Santos, Jose Luis. Departamento de Nutricion, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile, jsantosm@uc.c.
+MeSH Subject Headings
+ Child
+ Humans
+ *Leptin
+ *Insulin Resistance
+ Adiponectin
+ Cohort Studies
+ Blood Glucose
+ Biomarkers
+ Obesity
+ Triglycerides
+ Glucose
+ Body Mass Index
+Keyword Heading
+ Insulin resistance
+ adiponectin
+ leptin
+ leptin/adiponectin ratio
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: To assess the association between leptin/adiponectin ratio (LAR) and insulin resistance surrogates in prepubertal children.
+
+ Materials and methods: Study based on data from the Growth and Obesity Chilean Cohort Study (GOCS) involving 968 Chilean prepubertal children. Plasma insulin, leptin, and adiponectin were determined by immunoassays. Several common insulin resistance surrogates were calculated, including the homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride/HDL cholesterol index, triglyceride-glucose (TyG) index, and the TyG index corrected for body mass index (BMI; TyG-BMI) and waist circumference (WC; TyG-WC). Associations among variables were assessed using multiple linear and logistic regression analysis.
+
+ Results: There was a significant direct association between plasma leptin and LAR with BMI z-score but no association between plasma adiponectin and adiposity. After adjustments for sex and age, LAR was significantly associated with all insulin resistance surrogates (which were categorized using the 75th percentile as the cutoff point), with the TyG-WC index emerging as the surrogate with the highest magnitude of association (odds ratio [OR] 2.44, 95% confidence interval [CI] 2.05-2.9). After additional adjustment for BMI z-score, only the association between LAR and TyG-WC remained significant (OR 1.64, 95% CI 1.27-2.12).
+
+ Conclusion: Plasma leptin and LAR were strongly associated with several common insulin resistance surrogates in prepubertal children, most notably with the TyG-WC index. Associations between LAR and insulin resistance indexes were mainly driven by the effect of plasma leptin, which is also directly associated with increased adiposity.
+Registry Number/Name of Substance
+ 0 (Leptin). 0 (Adiponectin). 0 (Blood Glucose). 0 (Biomarkers). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.20945%2f2359-4292-2022-0353
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bravo&issn=2359-3997&title=Archives+of+Endocrinology+%26+Metabolism&atitle=Association+between+plasma+leptin%2Fadiponectin+ratio+and+insulin+resistance+indexes+in+prepubertal+children.&volume=68&issue=&spage=e220353&epage=&date=2024&doi=10.20945%2F2359-4292-2022-0353&pmid=38289144&sid=OVID:medline
+
+<102>
+Unique Identifier
+ 38492093
+Title
+ Association of Mediterranean diet adherence with disease progression, quality of life and physical activity, sociodemographic and anthropometric parameters, and serum biomarkers in community-dwelling older adults with multiple sclerosis: a cross-sectional study.
+Source
+ Aging-Clinical & Experimental Research. 36(1):73, 2024 Mar 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tryfonos C; Chrysafi M; Papadopoulou SK; Vadikolias K; Spanoudaki M; Mentzelou M; Fotiou D; Pavlidou E; Gkouvas G; Vorvolakos T; Michailidis A; Bisbinas A; Alexatou O; Giaginis C
+Author NameID
+ Giaginis, Constantinos; ORCID: http://orcid.org/0000-0003-2878-4831
+Authors Full Name
+ Tryfonos, Christina; Chrysafi, Maria; Papadopoulou, Sousana K; Vadikolias, Konstantinos; Spanoudaki, Maria; Mentzelou, Maria; Fotiou, Dimitrios; Pavlidou, Eleni; Gkouvas, Georgios; Vorvolakos, Theofanis; Michailidis, Apostolos; Bisbinas, Alexia; Alexatou, Olga; Giaginis, Constantinos.
+Institution
+ Tryfonos, Christina. Department of Food Science and Nutrition, School of Environment, University of the Aegean, 81400, Lemnos, Myrina, Greece.
+ Chrysafi, Maria. Department of Food Science and Nutrition, School of Environment, University of the Aegean, 81400, Lemnos, Myrina, Greece.
+ Papadopoulou, Sousana K. Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Thessaloniki, Greece.
+ Vadikolias, Konstantinos. Department of Neurology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
+ Spanoudaki, Maria. Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Thessaloniki, Greece.
+ Spanoudaki, Maria. Clinical Dietetics and Nutritional Department, 424 General Military Hospital, Thessaloniki, Greece.
+ Mentzelou, Maria. Department of Food Science and Nutrition, School of Environment, University of the Aegean, 81400, Lemnos, Myrina, Greece.
+ Fotiou, Dimitrios. Department of Neurology, School of Medicine, Aristoteleio University of Thessaloniki, Thessaloniki, Greece.
+ Pavlidou, Eleni. Department of Food Science and Nutrition, School of Environment, University of the Aegean, 81400, Lemnos, Myrina, Greece.
+ Gkouvas, Georgios. Clinical Dietetics and Nutritional Department, 424 General Military Hospital, Thessaloniki, Greece.
+ Vorvolakos, Theofanis. Department of Geriatric Psychiatry, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
+ Michailidis, Apostolos. 1st Department of Pathology, 424 General Military Hospital, Thessaloniki, Greece.
+ Bisbinas, Alexia. University General Hospital of Thessaloniki AHEPA, Thessaloniki, Greece.
+ Alexatou, Olga. Department of Food Science and Nutrition, School of Environment, University of the Aegean, 81400, Lemnos, Myrina, Greece.
+ Giaginis, Constantinos. Department of Food Science and Nutrition, School of Environment, University of the Aegean, 81400, Lemnos, Myrina, Greece. cgiaginis@aegean.gr.
+MeSH Subject Headings
+ Humans
+ Aged
+ Quality of Life/px [Psychology]
+ Diet, Mediterranean/px [Psychology]
+ *Diet, Mediterranean
+ Cross-Sectional Studies
+ Independent Living
+ *Multiple Sclerosis
+ Exercise
+ Obesity
+ Biomarkers
+ Disease Progression
+Keyword Heading
+ Disease progression
+ Mediterranean diet
+ Multiple sclerosis
+ Older adults
+ Quality of life
+ Symptoms
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Multiple sclerosis (MS) constitutes a chronic inflammatory and degenerative demyelinating disease, which can progressively lead to a broad range of sensorimotor, cognitive, visual, and autonomic function symptoms, independently of patient' age. However, the clinical studies that examine the role of dietary patterns against disease progression and symptomatology remain extremely scarce, especially concerning Mediterranean diet (MD) in the subgroup age of older adults with MS.
+
+ AIMS: The present study aimed to investigate the potential impact of MD compliance in disease progression and symptoms severity as well as quality of life and physical activity of community-dwelling older adults with MS.
+
+ METHODS: This is a cross-sectional conducted on 227 older adults with no history of other severe disease. Relevant questionnaires were applied to collect sociodemographic and anthropometric factors by face-to face interviews between patients and qualified personnel. Serum biomarkers were retrieved by patients' medical records.
+
+ RESULTS: Higher MD compliance was independently associated with younger patients' age, lower risk of overweight/obesity and abdominal obesity, decreased disease progression and higher muscle mass, as well as greater physical activity, better quality of life, and adequate serum ferritin and albumin levels CONCLUSIONS: MD may exert beneficial effects in older adults with MS. Future strategies and policies are highly recommended to inform both the general population and the older patients with MS for the beneficial effects of MD in preventing MS and in improving or even slowing down the disease progression and symptoms severity of MS. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs40520-024-02712-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tryfonos&issn=1594-0667&title=Aging-Clinical+%26+Experimental+Research&atitle=Association+of+Mediterranean+diet+adherence+with+disease+progression%2C+quality+of+life+and+physical+activity%2C+sociodemographic+and+anthropometric+parameters%2C+and+serum+biomarkers+in+community-dwelling+older+adults+with+multiple+sclerosis%3A+a+cross-sectional+study.&volume=36&issue=1&spage=73&epage=&date=2024&doi=10.1007%2Fs40520-024-02712-y&pmid=38492093&sid=OVID:medline
+
+<103>
+Unique Identifier
+ 37930396
+Title
+ Serum apelin-12 and obesity-related markers in Egyptian children with Down syndrome.
+Source
+ European Journal of Pediatrics. 183(1):461-470, 2024 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yahia S; Salem NA; El-Hawary A; Salem M; El-Farahaty RM; El-Gilany AE; Shoaib RMS; Noureldin MA
+Author NameID
+ Yahia, Sohier; ORCID: http://orcid.org/0000-0002-6974-5997
+ Salem, Nanees A; ORCID: http://orcid.org/0000-0001-6783-9095
+ El-Hawary, Amany; ORCID: http://orcid.org/0000-0003-0453-2381
+ El-Farahaty, Reham M; ORCID: http://orcid.org/0000-0001-7268-4139
+ El-Gilany, Abd El-Hady; ORCID: http://orcid.org/0000-0001-9376-6985
+ Shoaib, Rasha M S; ORCID: http://orcid.org/0000-0001-5150-7491
+ Noureldin, Mohamed Ahmed; ORCID: http://orcid.org/0000-0003-4841-7035
+Authors Full Name
+ Yahia, Sohier; Salem, Nanees A; El-Hawary, Amany; Salem, Mohamed; El-Farahaty, Reham M; El-Gilany, Abd El-Hady; Shoaib, Rasha M S; Noureldin, Mohamed Ahmed.
+Institution
+ Yahia, Sohier. Department of Pediatrics, Genetics Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
+ Salem, Nanees A. Department of Pediatrics, Endocrinology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt. nanees.salem@gmail.com.
+ Salem, Nanees A. Mansoura University Children's Hospital, El-Gomhoria St, Post Office 35516, Box 50, Mansoura, 53355, Egypt. nanees.salem@gmail.com.
+ El-Hawary, Amany. Department of Pediatrics, Endocrinology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
+ Salem, Mohamed. Mansoura General Hospital, Mansoura, Egypt.
+ El-Farahaty, Reham M. Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
+ El-Gilany, Abd El-Hady. Public Health Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
+ Shoaib, Rasha M S. Food and Dairy Sciences and Technology Department, Faculty of Environmental Agricultural Sciences, Arish University, El-Arish, Egypt.
+ Noureldin, Mohamed Ahmed. Department of Pediatrics, Faculty of Medicine, Horus University, Damietta, Egypt.
+MeSH Subject Headings
+ Adult
+ Humans
+ Child
+ *Insulin Resistance
+ Cross-Sectional Studies
+ Down Syndrome/co [Complications]
+ Down Syndrome/di [Diagnosis]
+ *Down Syndrome
+ Egypt
+ Body Mass Index
+ Obesity/co [Complications]
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome
+ Insulin
+ Biomarkers
+ Blood Glucose/me [Metabolism]
+ Lipids
+ *Intercellular Signaling Peptides and Proteins
+Keyword Heading
+ Apelin-12
+ Down syndrome
+ Metabolic syndrome
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Children with Down syndrome (DS) exhibit higher overweight/obesity rates than their typically developing peers. Apelin-12 is a bioactive adipokine that exerts vital roles in obesity-related cardiometabolic comorbidities. To date, apelin-12 has not been investigated in obese-DS. This study aimed to explore the possible association between serum apelin-12 and obesity-related markers and to evaluate the efficiency of apelin-12 in the prediction of metabolic syndrome (MetS) in obese-DS compared to BMI Z-score matched obese-control. The cross-sectional study included 150 prepubertal children classified into three groups; obese-DS (n = 50), obese-control (n = 50), and normal-weight-control (n = 50). Anthropometric parameters, body adiposity, fasting serum levels of blood glucose (FBG), insulin, lipid profile, and apelin-12 were evaluated. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from FBG and insulin. MetS was defined using Adult Treatment Panel III criteria modified for the pediatric age group. ROC curves were analyzed to evaluate the efficiency of apelin-12 in predicting MetS in obesity groups. Obese-DS exhibited higher body adiposity with marked central fat distribution, atherogenic lipid profile, and higher HOMA-IR compared to obese-control. Apelin-12 was significantly higher in obese-DS and obese-DS with MetS compared to obese-control and obese-control with MetS respectively (p < 0.001). The increase in apelin-12 with higher obesity grades was pronounced in obese-DS. Apelin-12 strongly correlated with body adiposity, several MetS risk factors, and HOMA-IR in obese-DS. Significantly higher AUC for apelin-12 in the diagnosis of MetS among obese-DS than obese-control (AUC = 0.948 vs. AUC = 0.807; p = 0.04).
+
+ CONCLUSIONS: The current study supports the crucial role of apelin-12 in obesity-related clinical and biochemical markers and in MetS in obese-DS and obese-control. Serum apelin-12 is a potential diagnostic biomarker for MetS with greater performance in obese-DS than obese-control raising its potential for clinical and therapeutic applications.
+
+ WHAT IS KNOWN: * Obese-DS children displayed excess body adiposity, Pronounced central fat distribution, atherogenic lipid profile, higher HOMA-IR, and higher prevalence of MetS than obese-control.
+
+ WHAT IS NEW: * Higher serum apelin-12 was observed in obese-DS and obese-DS with MetS than obese-control and obese-control with MetS respectively. The increase in apelin-12 level with increasing obesity grades was more pronounced in obese-DS. * Apelin-12 strongly correlated with obesity-related markers and MetS components in obese-DS. Apelin-12 performed better as a diagnostic biomarker for MetS in obese-DS than obese-control. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (apelin-12 peptide). 0 (Insulin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). 0 (Intercellular Signaling Peptides and Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs00431-023-05315-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yahia&issn=0340-6199&title=European+Journal+of+Pediatrics&atitle=Serum+apelin-12+and+obesity-related+markers+in+Egyptian+children+with+Down+syndrome.&volume=183&issue=1&spage=461&epage=470&date=2024&doi=10.1007%2Fs00431-023-05315-3&pmid=37930396&sid=OVID:medline
+
+<104>
+Unique Identifier
+ 38474344
+Title
+ Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition. [Review]
+Source
+ Cells. 13(5), 2024 Feb 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lopez-Yus M; Horndler C; Borlan S; Bernal-Monterde V; Arbones-Mainar JM
+Author NameID
+ Bernal-Monterde, Vanesa; ORCID: https://orcid.org/0000-0002-4016-2165
+ Arbones-Mainar, Jose M; ORCID: https://orcid.org/0000-0002-8982-3737
+Authors Full Name
+ Lopez-Yus, Marta; Horndler, Carlos; Borlan, Sofia; Bernal-Monterde, Vanesa; Arbones-Mainar, Jose M.
+Institution
+ Lopez-Yus, Marta. Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, University Hospital Miguel Servet, 50009 Zaragoza, Spain.
+ Lopez-Yus, Marta. Instituto Aragones de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain.
+ Lopez-Yus, Marta. Instituto de Investigacion Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain.
+ Horndler, Carlos. Instituto de Investigacion Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain.
+ Horndler, Carlos. Pathology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
+ Borlan, Sofia. General and Digestive Surgery Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
+ Bernal-Monterde, Vanesa. Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, University Hospital Miguel Servet, 50009 Zaragoza, Spain.
+ Bernal-Monterde, Vanesa. Instituto Aragones de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain.
+ Bernal-Monterde, Vanesa. Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
+ Arbones-Mainar, Jose M. Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, University Hospital Miguel Servet, 50009 Zaragoza, Spain.
+ Arbones-Mainar, Jose M. Instituto Aragones de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain.
+ Arbones-Mainar, Jose M. Instituto de Investigacion Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain.
+ Arbones-Mainar, Jose M. CIBER Fisiopatologia Obesidad y Nutricion (CIBERObn), Instituto Salud Carlos III, 28029 Madrid, Spain.
+MeSH Subject Headings
+ Humans
+ Obesity/me [Metabolism]
+ *Obesity
+ Adipose Tissue, White/me [Metabolism]
+ *Adipose Tissue, White
+ Adipose Tissue, Brown/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Liver/me [Metabolism]
+Keyword Heading
+ NAFLD
+ adipose tissue
+ biomarkers
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as a dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, and immune responses. It comprises mainly two types: white adipose tissue (WAT) for energy storage and brown adipose tissue (BAT) for thermogenesis, with beige adipocytes demonstrating the plasticity of these cells. WAT, beyond lipid storage, is involved in various metabolic activities, notably lipogenesis and lipolysis, critical for maintaining energy homeostasis. It also functions as an endocrine organ, secreting adipokines that influence metabolic, inflammatory, and immune processes. However, dysfunction in WAT, especially related to obesity, leads to metabolic disturbances, including the inability to properly store excess lipids, resulting in ectopic fat deposition in organs like the liver, contributing to non-alcoholic fatty liver disease (NAFLD). This narrative review delves into the multifaceted roles of WAT, its composition, metabolic functions, and the pathophysiology of WAT dysfunction. It also explores diagnostic approaches for adipose-related disorders, emphasizing the importance of accurately assessing AT distribution and understanding the complex relationships between fat compartments and metabolic health. Furthermore, it discusses various therapeutic strategies, including innovative therapeutics like adipose-derived mesenchymal stem cells (ADMSCs)-based treatments and gene therapy, highlighting the potential of precision medicine in targeting obesity and its associated complications.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fcells13050380
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lopez-Yus&issn=2073-4409&title=Cells&atitle=Unraveling+Adipose+Tissue+Dysfunction%3A+Molecular+Mechanisms%2C+Novel+Biomarkers%2C+and+Therapeutic+Targets+for+Liver+Fat+Deposition.&volume=13&issue=5&spage=&epage=&date=2024&doi=10.3390%2Fcells13050380&pmid=38474344&sid=OVID:medline
+
+<105>
+Unique Identifier
+ 38473723
+Title
+ The Effect of a Ketogenic Diet versus Mediterranean Diet on Clinical and Biochemical Markers of Inflammation in Patients with Obesity and Psoriatic Arthritis: A Randomized Crossover Trial.
+Source
+ International Journal of Molecular Sciences. 25(5), 2024 Feb 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lambadiari V; Katsimbri P; Kountouri A; Korakas E; Papathanasi A; Maratou E; Pavlidis G; Pliouta L; Ikonomidis I; Malisova S; Vlachos D; Papadavid E
+Author NameID
+ Ikonomidis, Ignatios; ORCID: https://orcid.org/0000-0001-8241-7886
+Authors Full Name
+ Lambadiari, Vaia; Katsimbri, Pelagia; Kountouri, Aikaterini; Korakas, Emmanouil; Papathanasi, Argyro; Maratou, Eirini; Pavlidis, George; Pliouta, Loukia; Ikonomidis, Ignatios; Malisova, Sofia; Vlachos, Dionysios; Papadavid, Evangelia.
+Institution
+ Lambadiari, Vaia. Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
+ Katsimbri, Pelagia. Rheumatology and Clinical Immunology Unit, Fourth Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
+ Kountouri, Aikaterini. Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
+ Korakas, Emmanouil. Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
+ Papathanasi, Argyro. Second Department of Dermatology and Venereology, University of Athens Medical School, 12462 Athens, Greece.
+ Maratou, Eirini. Department of Clinical Biochemistry, Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece.
+ Pavlidis, George. Second Cardiology Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
+ Pliouta, Loukia. Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
+ Ikonomidis, Ignatios. Second Cardiology Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
+ Malisova, Sofia. Independent Researcher, 11142 Athens, Greece.
+ Vlachos, Dionysios. Independent Researcher, 16451 Athens, Greece.
+ Papadavid, Evangelia. Second Department of Dermatology and Venereology, University of Athens Medical School, 12462 Athens, Greece.
+MeSH Subject Headings
+ Humans
+ *Arthritis, Psoriatic
+ *Diet, Ketogenic
+ *Diet, Mediterranean
+ Cross-Over Studies
+ *Psoriasis
+ Inflammation
+ Obesity
+ Biomarkers
+Keyword Heading
+ DAPSA score
+ Ketogenic diet
+ Mediterranean diet
+ PASI score
+ diet intervention
+ inflammation
+ interleukins
+ obesity
+ psoriasis
+ psoriatic arthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The effect of different diet patterns on psoriasis (PSO) and psoriatic arthritis (PSA) is unknown. Tauhe aim of our study was to evaluate the effectiveness of a Mediterranean diet (MD) and Ketogenic diet (KD), in patients with PSO and PSA. Twenty-six patients were randomly assigned to start either with MD or KD for a period of 8 weeks. After a 6-week washout interval, the two groups were crossed over to the other type of diet for 8 weeks. At the end of this study, MD and KD resulted in significant reduction in weight (p = 0.002, p < 0.001, respectively), in BMI (p = 0.006, p < 0.001, respectively), in waist circumference (WC) (p = 0.001, p < 0.001, respectively), in total fat mass (p = 0.007, p < 0.001, respectively), and in visceral fat (p = 0.01, p < 0.001, respectively), in comparison with baseline. After KD, patients displayed a significant reduction in the Psoriasis Area and Severity Index (PASI) (p = 0.04), Disease Activity Index of Psoriatic Arthritis (DAPSA) (p = 0.004), interleukin (IL)-6 (p = 0.047), IL-17 (p = 0.042), and IL-23 (p = 0.037), whereas no significant differences were observed in these markers after MD (p > 0.05), compared to baseline. The 22-week MD-KD diet program in patients with PSO and PSA led to beneficial results in markers of inflammation and disease activity, which were mainly attributed to KD.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fijms25052475
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lambadiari&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=The+Effect+of+a+Ketogenic+Diet+versus+Mediterranean+Diet+on+Clinical+and+Biochemical+Markers+of+Inflammation+in+Patients+with+Obesity+and+Psoriatic+Arthritis%3A+A+Randomized+Crossover+Trial.&volume=25&issue=5&spage=2475&epage=&date=2024&doi=10.3390%2Fijms25052475&pmid=38473723&sid=OVID:medline
+
+<106>
+Unique Identifier
+ 38066623
+Title
+ Isthmin-1 (ISM1), a novel adipokine that reflects abdominal adipose tissue distribution in individuals with obesity.
+Source
+ Cardiovascular Diabetology. 22(1):335, 2023 12 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lopez-Yus M; Casamayor C; Soriano-Godes JJ; Borlan S; Gonzalez-Irazabal Y; Garcia-Sobreviela MP; Garcia-Rodriguez B; Del Moral-Bergos R; Calmarza P; Artigas JM; Lorente-Cebrian S; Bernal-Monterde V; Sanz-Paris A; Arbones-Mainar JM
+Authors Full Name
+ Lopez-Yus, Marta; Casamayor, Carmen; Soriano-Godes, Juan Jose; Borlan, Sofia; Gonzalez-Irazabal, Yolanda; Garcia-Sobreviela, Maria Pilar; Garcia-Rodriguez, Beatriz; Del Moral-Bergos, Raquel; Calmarza, Pilar; Artigas, Jose Maria; Lorente-Cebrian, Silvia; Bernal-Monterde, Vanesa; Sanz-Paris, Alejandro; Arbones-Mainar, Jose M.
+Institution
+ Lopez-Yus, Marta. Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, University Hospital Miguel Servet, Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain.
+ Lopez-Yus, Marta. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Casamayor, Carmen. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Casamayor, Carmen. Endocrine, Bariatric and Breast Surgery Unit, General and Digestive Surgery Department, Miguel Servet University Hospital, Zaragoza, Spain.
+ Soriano-Godes, Juan Jose. Department of Radiology, Royo-Villanova Hospital, Zaragoza, Spain.
+ Borlan, Sofia. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Borlan, Sofia. Endocrine, Bariatric and Breast Surgery Unit, General and Digestive Surgery Department, Miguel Servet University Hospital, Zaragoza, Spain.
+ Gonzalez-Irazabal, Yolanda. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Gonzalez-Irazabal, Yolanda. Clinical Biochemistry Department, Miguel Servet University Hospital, Zaragoza, Spain.
+ Garcia-Sobreviela, Maria Pilar. Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, University Hospital Miguel Servet, Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain.
+ Garcia-Sobreviela, Maria Pilar. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Garcia-Rodriguez, Beatriz. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Garcia-Rodriguez, Beatriz. Clinical Biochemistry Department, Miguel Servet University Hospital, Zaragoza, Spain.
+ Del Moral-Bergos, Raquel. Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, University Hospital Miguel Servet, Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain.
+ Del Moral-Bergos, Raquel. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Calmarza, Pilar. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Calmarza, Pilar. Clinical Biochemistry Department, Miguel Servet University Hospital, Zaragoza, Spain.
+ Calmarza, Pilar. CIBER Enfermedad Cardiovascular (CIBERCV), Instituto Salud Carlos III, Madrid, Spain.
+ Artigas, Jose Maria. Department of Radiology, Miguel Servet University Hospital, Zaragoza, Spain.
+ Lorente-Cebrian, Silvia. Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, University Hospital Miguel Servet, Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain.
+ Lorente-Cebrian, Silvia. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Lorente-Cebrian, Silvia. Department of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Health and Sport Science, University of Zaragoza, Zaragoza, Spain.
+ Lorente-Cebrian, Silvia. Instituto Agroalimentario de Aragon (IA2) (Universidad de Zaragoza-CITA), Zaragoza, Spain.
+ Bernal-Monterde, Vanesa. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Bernal-Monterde, Vanesa. Gastroenterology Department, Miguel Servet University Hospital, Zaragoza, Spain.
+ Sanz-Paris, Alejandro. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain.
+ Sanz-Paris, Alejandro. Endocrinology and Nutrition Department, Miguel Servet University Hospital, Zaragoza, Spain.
+ Arbones-Mainar, Jose M. Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, University Hospital Miguel Servet, Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain. jmarbones.iacs@aragon.es.
+ Arbones-Mainar, Jose M. Instituto de Investigacion Sanitaria (IIS) Aragon, Zaragoza, 50009, Spain. jmarbones.iacs@aragon.es.
+ Arbones-Mainar, Jose M. CIBER Fisiopatologia Obesidad y Nutricion (CIBERObn), Instituto Salud Carlos III, Madrid, Spain. jmarbones.iacs@aragon.es.
+ Arbones-Mainar, Jose M. Adipocyte and Fat Biology Laboratory (AdipoFat), Unidad de Investigacion Traslacional, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud (IACS), Instituto de Investigacion Sanitaria (IIS) Aragon, Isabel la Catolica, 1-3, Zaragoza, 50009, Spain. jmarbones.iacs@aragon.es.
+MeSH Subject Headings
+ Female
+ Humans
+ Male
+ Abdominal Fat/dg [Diagnostic Imaging]
+ Abdominal Fat/me [Metabolism]
+ Adipokines/me [Metabolism]
+ *Adipokines
+ Adipose Tissue/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Intra-Abdominal Fat/dg [Diagnostic Imaging]
+ Intra-Abdominal Fat/me [Metabolism]
+ Obesity/me [Metabolism]
+ *Obesity
+ Subcutaneous Fat/dg [Diagnostic Imaging]
+ Subcutaneous Fat/me [Metabolism]
+ Thrombospondins/me [Metabolism]
+ *Thrombospondins
+Keyword Heading
+ Biomarker
+ CT-Scan
+ Expandability
+ Subcutaneous fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The assessment of obesity-related health risks has traditionally relied on the Body Mass Index and waist circumference, but their limitations have propelled the need for a more comprehensive approach. The differentiation between visceral (VIS) and subcutaneous (SC) fat provides a finer-grained understanding of these risks, yet practical assessment methods are lacking. We hypothesized that combining the SC-VIS fat ratio with non-invasive biomarkers could create a valuable tool for obesity-related risk assessment.
+
+ METHODS AND RESULTS: A clinical study of 125 individuals with obesity revealed significant differences in abdominal fat distribution measured by CT-scan among genders and distinct models of obesity, including visceral, subcutaneous, and the SC/VIS ratio. Stratification based on these models highlighted various metabolic changes. The SC/VIS ratio emerged as an excellent metric to differentiate metabolic status. Gene expression analysis identified candidate biomarkers, with ISM1 showing promise. Subsequent validation demonstrated a correlation between ISM1 levels in SC and plasma, reinforcing its potential as a non-invasive biomarker for fat distribution. Serum adipokine levels also correlated with the SC/VIS ratio. The Receiver Operating Characteristic analysis revealed ISM1's efficacy in discriminating individuals with favorable metabolic profiles based on adipose tissue distribution. Correlation analysis also suggested that ISM1 was involved in glucose regulation pathways.
+
+ CONCLUSION: The study's results support the hypothesis that the SC-VIS fat ratio and its derived non-invasive biomarkers can comprehensively assess obesity-related health risks. ISM1 could predict abdominal fat partitioning and be a potential biomarker for evaluating obesity-related health risks. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (ISM1 protein, human). 0 (Thrombospondins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12933-023-02075-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lopez-Yus&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Isthmin-1+%28ISM1%29%2C+a+novel+adipokine+that+reflects+abdominal+adipose+tissue+distribution+in+individuals+with+obesity.&volume=22&issue=1&spage=335&epage=&date=2023&doi=10.1186%2Fs12933-023-02075-0&pmid=38066623&sid=OVID:medline
+
+<107>
+Unique Identifier
+ 35442131
+Title
+ Physical activity and obesity spectrum disorders in post-bariatric surgery patients: A systematic review and Meta-analysis.
+Source
+ Critical Reviews in Food Science & Nutrition. 63(26):8161-8172, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gasmi A; Boukhmis B; Bjorklund G; Elkhidir IH; Semenova Y; Dosa A; Piscopo S; Temitope AH; Noor S; Costea DO
+Author NameID
+ Gasmi, Amin; ORCID: https://orcid.org/0000-0003-2165-8373
+ Bjorklund, Geir; ORCID: https://orcid.org/0000-0003-2632-3935
+ Piscopo, Salva; ORCID: https://orcid.org/0000-0001-8484-4654
+Authors Full Name
+ Gasmi, Amin; Boukhmis, Boukelia; Bjorklund, Geir; Elkhidir, Ibrahim H; Semenova, Yuliya; Dosa, Alexandru; Piscopo, Salva; Temitope, Adekunle Hakeem; Noor, Sadaf; Costea, Daniel-Ovidiu.
+Institution
+ Gasmi, Amin. Societe Francophone de Nutritherapie et de Nutrigenetique Appliquee, Villeurbanne, France.
+ Boukhmis, Boukelia. Britannia Sport and Exercise Science, Edinburgh, United Kingdom.
+ Bjorklund, Geir. Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway.
+ Elkhidir, Ibrahim H. Department of Pathology, Faculty of Medicine, University of Khartoum, Sudan.
+ Semenova, Yuliya. Semey Medical University, Semey, Kazakhstan.
+ Semenova, Yuliya. CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, Kazakhstan.
+ Dosa, Alexandru. Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania.
+ Piscopo, Salva. Societe Francophone de Nutritherapie et de Nutrigenetique Appliquee, Villeurbanne, France.
+ Temitope, Adekunle Hakeem. Federal University of Technology, Akure, Nigeria.
+ Noor, Sadaf. Federal University of Technology, Akure, Nigeria.
+ Noor, Sadaf. Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan, Pakistan.
+ Costea, Daniel-Ovidiu. Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania.
+MeSH Subject Headings
+ Adult
+ Humans
+ *Obesity
+ *Bariatric Surgery
+ Exercise
+ Weight Loss
+ Biomarkers
+Keyword Heading
+ Intervention
+ bariatric surgery
+ physical activity
+ surgery patients
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: This systematic review and meta-analysis is based on randomized controlled trials evaluating the effect of physical activity on weight loss in adults undergoing bariatric surgery. The study compared certain biomarkers for individuals with and without physical activity after bariatric surgery. Secondary, the study identified potential successful interventions for the target population.
+
+ METHOD: PubMed, Embase, OVID, CINAHL, and Cochrane Library were searched from January 2000 to December 2020. Intervention studies on the effect of physical activity in adults after bariatric surgery were selected, included, and analyzed following the PRISMA guidelines. The primary outcome was weight loss followed by selected biomarkers.
+
+ RESULTS: Two independent reviewers extracted data and conducted quality assessments. Of the 11 studies included, six reported BMI, two reported fat-free mass, three reported fat mass, two reported waist-hip ratio, and two reported waist circumference. Six studies measuring change from baseline BMI reported a significant intervention effect: SMD = -0.93 (-1.65;-0.20) with high heterogeneity of included trials (I2 = 72%). There was no significant difference between control and intervention groups for other outcomes.
+
+ CONCLUSION: BMI as a measure of physical activity positively impacts the target population. Large-scale studies with better criteria and a longer evaluation follow-up may finalize pronounced outcomes.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Meta-Analysis. Systematic Review. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1080%2f10408398.2022.2056868
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gasmi&issn=1040-8398&title=Critical+Reviews+in+Food+Science+%26+Nutrition&atitle=Physical+activity+and+obesity+spectrum+disorders+in+post-bariatric+surgery+patients%3A+A+systematic+review+and+Meta-analysis.&volume=63&issue=26&spage=8161&epage=8172&date=2023&doi=10.1080%2F10408398.2022.2056868&pmid=35442131&sid=OVID:medline
+
+<108>
+Unique Identifier
+ 38336379
+Title
+ Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796.
+Source
+ Journal of Pharmacology & Experimental Therapeutics. 388(3):813-826, 2024 02 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Thornton P; Reader V; Digby Z; Smolak P; Lindsay N; Harrison D; Clarke N; Watt AP
+Author NameID
+ Thornton, Peter; ORCID: https://orcid.org/0000-0002-2489-3507
+Authors Full Name
+ Thornton, Peter; Reader, Valerie; Digby, Zsofia; Smolak, Pamela; Lindsay, Nicola; Harrison, David; Clarke, Nick; Watt, Alan P.
+Institution
+ Thornton, Peter. NodThera, Cambridge, United Kingdom (P.T., V.R., Z.D., N.L., D.H., N.C., A.P.W.) and Seattle, Washington (P.S.) pete.thornton@nodthera.com.
+ Reader, Valerie. NodThera, Cambridge, United Kingdom (P.T., V.R., Z.D., N.L., D.H., N.C., A.P.W.) and Seattle, Washington (P.S.).
+ Digby, Zsofia. NodThera, Cambridge, United Kingdom (P.T., V.R., Z.D., N.L., D.H., N.C., A.P.W.) and Seattle, Washington (P.S.).
+ Smolak, Pamela. NodThera, Cambridge, United Kingdom (P.T., V.R., Z.D., N.L., D.H., N.C., A.P.W.) and Seattle, Washington (P.S.).
+ Lindsay, Nicola. NodThera, Cambridge, United Kingdom (P.T., V.R., Z.D., N.L., D.H., N.C., A.P.W.) and Seattle, Washington (P.S.).
+ Harrison, David. NodThera, Cambridge, United Kingdom (P.T., V.R., Z.D., N.L., D.H., N.C., A.P.W.) and Seattle, Washington (P.S.).
+ Clarke, Nick. NodThera, Cambridge, United Kingdom (P.T., V.R., Z.D., N.L., D.H., N.C., A.P.W.) and Seattle, Washington (P.S.).
+ Watt, Alan P. NodThera, Cambridge, United Kingdom (P.T., V.R., Z.D., N.L., D.H., N.C., A.P.W.) and Seattle, Washington (P.S.).
+MeSH Subject Headings
+ Mice
+ Animals
+ Inflammasomes/me [Metabolism]
+ *Inflammasomes
+ NLR Family, Pyrin Domain-Containing 3 Protein/me [Metabolism]
+ Gliosis/dt [Drug Therapy]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Cardiovascular Diseases
+ Mice, Inbred NOD
+ Inflammation/dt [Drug Therapy]
+ Inflammation/me [Metabolism]
+ Obesity/me [Metabolism]
+ Weight Loss
+ Biomarkers
+ Glucagon-Like Peptides
+ Mice, Inbred C57BL
+Abstract
+ Systemic and cerebral inflammatory responses are implicated in the pathogenesis of obesity and associated metabolic impairment. While the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been linked to obesity-associated inflammation, whether it contributes to the development or maintenance of obesity is unknown. We provide support for a direct role of saturated fatty acids, such as palmitic acid, as NLRP3 activating stimuli in obese states. To investigate whether NLRP3 activation contributes to the pathogenesis of diet-induced obesity (DIO) in mice, we tested two different clinical-stage NLRP3 inflammasome inhibitors. We demonstrate a contributory role of this key inflammasome to established obesity and associated systemic and cerebral inflammation. By comparing their effects to calorie restriction, we aimed to identify specific NLRP3-sensitive mechanisms contributing to obesity-induced inflammation (as opposed to be those regulated by weight loss per se). In addition, a direct comparison of an NLRP3 inhibitor to a glucagon like peptide-1 receptor agonist, semaglutide (Wegovy), in the DIO model allowed an appreciation of the relative efficacy of these two therapeutic strategies on obesity, its associated systemic inflammatory response, and cerebral gliosis. We show that two structurally distinct, NLRP3 inhibitors, NT-0249 and NT-0796, reverse obesity in the DIO mouse model and that brain exposure appears necessary for efficacy. In support of this, we show that DIO-driven hypothalamic glial fibrillary acidic protein expression is blocked by dosing with NT-0249/NT-0796. While matching weight loss driven by semaglutide or calorie restriction, remarkably, NLRP3 inhibition provided enhanced improvements in disease-relevant biomarkers of acute phase response, cardiovascular inflammation, and lipid metabolism. SIGNIFICANCE STATEMENT: Obesity is a global health concern that predisposes individuals to chronic disease such as diabetes and cardiovascular disease at least in part by promoting systemic inflammation. We report that in mice fed a high-fat, obesogenic diet, obesity is reversed by either of two inhibitors of the intracellular inflammatory mediator NLRP3. Furthermore, NLRP3 inhibition reduces both hypothalamic gliosis and circulating biomarkers of cardiovascular disease risk beyond what can be achieved by either the glucagon like peptide-1 agonist semaglutide or calorie restriction alone. Copyright © 2024 by The Author(s).
+Registry Number/Name of Substance
+ 0 (Inflammasomes). 0 (NLR Family, Pyrin Domain-Containing 3 Protein). 0 (Biomarkers). 62340-29-8 (Glucagon-Like Peptides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1124%2fjpet.123.002013
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Thornton&issn=0022-3565&title=Journal+of+Pharmacology+%26+Experimental+Therapeutics&atitle=Reversal+of+High+Fat+Diet-Induced+Obesity%2C+Systemic+Inflammation%2C+and+Astrogliosis+by+the+NLRP3+Inflammasome+Inhibitors+NT-0249+and+NT-0796.&volume=388&issue=3&spage=813&epage=826&date=2024&doi=10.1124%2Fjpet.123.002013&pmid=38336379&sid=OVID:medline
+
+<109>
+Unique Identifier
+ 37909946
+Title
+ Adiposity, Weight Change, and Urinary Melatonin Levels among Men in the Multiethnic Cohort.
+Source
+ Cancer Epidemiology, Biomarkers & Prevention. 33(1):136-142, 2024 01 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chowdhury-Paulino IM; Vaselkiv JB; Cheng I; Schernhammer ES; Lin Z; Haiman CA; Le Marchand L; Valdimarsdottir U; Wilkens LR; Markt SC; Mucci LA
+Author NameID
+ Chowdhury-Paulino, Ilkania M; ORCID: https://orcid.org/0000-0001-7331-7576
+ Vaselkiv, Jane B; ORCID: https://orcid.org/0000-0001-7702-9504
+ Cheng, Iona; ORCID: https://orcid.org/0000-0003-4132-2893
+ Schernhammer, Eva S; ORCID: https://orcid.org/0000-0002-4337-9415
+ Lin, Zhike; ORCID: https://orcid.org/0009-0008-3549-9688
+ Haiman, Christopher A; ORCID: https://orcid.org/0000-0002-0097-9971
+ Le Marchand, Loic; ORCID: https://orcid.org/0000-0001-5013-980X
+ Valdimarsdottir, Unnur; ORCID: https://orcid.org/0000-0001-5382-946X
+ Wilkens, Lynne R; ORCID: https://orcid.org/0000-0001-8408-4536
+ Markt, Sarah C; ORCID: https://orcid.org/0000-0003-2873-0358
+ Mucci, Lorelei A; ORCID: https://orcid.org/0000-0002-2551-4927
+Authors Full Name
+ Chowdhury-Paulino, Ilkania M; Vaselkiv, Jane B; Cheng, Iona; Schernhammer, Eva S; Lin, Zhike; Haiman, Christopher A; Le Marchand, Loic; Valdimarsdottir, Unnur; Wilkens, Lynne R; Markt, Sarah C; Mucci, Lorelei A.
+Institution
+ Chowdhury-Paulino, Ilkania M. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
+ Vaselkiv, Jane B. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
+ Cheng, Iona. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
+ Schernhammer, Eva S. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Schernhammer, Eva S. Department of Epidemiology, Medical University of Vienna, Vienna, Austria.
+ Lin, Zhike. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
+ Haiman, Christopher A. Keck School of Medicine, University of Southern California, Los Angeles, California.
+ Le Marchand, Loic. University of Hawai'i Cancer Center, Honolulu, Hawaii.
+ Valdimarsdottir, Unnur. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
+ Valdimarsdottir, Unnur. Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland.
+ Valdimarsdottir, Unnur. Unit of Integrative Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
+ Wilkens, Lynne R. University of Hawai'i Cancer Center, Honolulu, Hawaii.
+ Markt, Sarah C. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
+ Markt, Sarah C. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.
+ Mucci, Lorelei A. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
+ Mucci, Lorelei A. American Cancer Society, Atlanta, Georgia.
+MeSH Subject Headings
+ Male
+ Humans
+ Female
+ Adiposity
+ *Melatonin
+ Obesity/co [Complications]
+ Ethnicity
+ Weight Gain
+ Biomarkers
+ Neoplasms/co [Complications]
+ *Neoplasms
+Abstract
+ BACKGROUND: Low levels of 6-sulfatoxymelatonin, the primary urinary metabolite of melatonin, have been linked to cancer and cardiometabolic outcomes in White and female populations.
+
+ METHODS: We examined the association between adulthood adiposity and 6-sulfatoxymelatonin levels in a racially and ethnically diverse population. Our study included 4,078 men in the Multiethnic Cohort with adiposity measurements at enrollment (1993-1996) and biomarkers measured in urines collected in 1995 and 2005. Multivariable linear regression models were used to estimate the percent change in 6-sulfatoxymelatonin levels and 95% confidence intervals (CI). Associations were examined separately by racial/ethnic group.
+
+ RESULTS: The prevalence of obesity varied by race and ethnicity, from 10% for Japanese American men to 34% for Native Hawaiian men. Compared with men with normal body mass index (BMI), men who were overweight (-7.8%; 95% CI, -11.9 to -3.5%) and obese (-18.1%; 95% CI, -23.2 to -12.6%) had significantly lower 6-sulfatoxymelatonin levels adjusting for potential confounding factors. Increasing weight gain in adulthood was also associated with lower 6-sulfatoxymelatonin (Ptrend < 0.0001). The inverse associations for BMI and weight change were qualitatively similar across racial and ethnic groups.
+
+ CONCLUSIONS: Obesity is inversely associated with melatonin in a racially diverse population. This finding is relevant given higher rates of obesity among Black, Native Hawaiian, and Latino men, as well as potential racial and ethnic differences in circadian function.
+
+ IMPACT: Melatonin may be a relevant biomarker among obesity-associated malignancies and could shed light on a potential mechanism of cancer disparities. Copyright ©2023 American Association for Cancer Research.
+Registry Number/Name of Substance
+ JL5DK93RCL (Melatonin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1158%2f1055-9965.EPI-23-0860
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chowdhury-Paulino&issn=1055-9965&title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&atitle=Adiposity%2C+Weight+Change%2C+and+Urinary+Melatonin+Levels+among+Men+in+the+Multiethnic+Cohort.&volume=33&issue=1&spage=136&epage=142&date=2024&doi=10.1158%2F1055-9965.EPI-23-0860&pmid=37909946&sid=OVID:medline
+
+<110>
+Unique Identifier
+ 38465005
+Title
+ Surrogate markers of adiposity and elevated blood pressure in African children.
+Source
+ The Pan African medical journal. 46:114, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ndoadoumgue AL; Nyaga UF; Noubiap JJ
+Authors Full Name
+ Ndoadoumgue, Aude Laetitia; Nyaga, Ulrich Flore; Noubiap, Jean Jacques.
+Institution
+ Ndoadoumgue, Aude Laetitia. School of Health and Related Research, The University of Sheffield, Sheffield, United Kingdom.
+ Nyaga, Ulrich Flore. Health Data Acumen, Nairobi, Kenya.
+ Noubiap, Jean Jacques. Department of Medicine, University of California-San Francisco, San Francisco, California, USA.
+MeSH Subject Headings
+ Child
+ Humans
+ Adiposity/ph [Physiology]
+ *Adiposity
+ Blood Pressure/ph [Physiology]
+ Obesity/ep [Epidemiology]
+ Hypertension/ep [Epidemiology]
+ *Hypertension
+ Biomarkers
+ Body Mass Index
+ Risk Factors
+Keyword Heading
+ Hypertension
+ children
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.11604%2fpamj.2023.46.114.42371
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ndoadoumgue&issn=1937-8688&title=The+Pan+African+medical+journal&atitle=Surrogate+markers+of+adiposity+and+elevated+blood+pressure+in+African+children.&volume=46&issue=&spage=114&epage=&date=2023&doi=10.11604%2Fpamj.2023.46.114.42371&pmid=38465005&sid=OVID:medline
+
+<111>
+Unique Identifier
+ 38299570
+Title
+ Impact of Weight Management on Obesity-Driven Biomarkers of Prostate Cancer Progression.
+Source
+ Journal of Urology. 211(4):552-562, 2024 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bechtel MD; Michel C; Srinivasan P; Chalise P; Parker WP; Mirza M; Thrasher B; Gibbs HD; DiGiovanni J; Hamilton-Reeves J
+Author NameID
+ Hamilton-Reeves, Jill; ORCID: https://orcid.org/0000-0002-0973-1542
+Authors Full Name
+ Bechtel, Misty D; Michel, Carrie; Srinivasan, Pugazhendhi; Chalise, Prabhakar; Parker, William P; Mirza, Moben; Thrasher, Brantley; Gibbs, Heather D; DiGiovanni, John; Hamilton-Reeves, Jill.
+Institution
+ Bechtel, Misty D. Department of Urology, University of Kansas Medical Center, Kansas City, Kansas.
+ Michel, Carrie. Department of Urology, University of Kansas Medical Center, Kansas City, Kansas.
+ Srinivasan, Pugazhendhi. Department of Urology, University of Kansas Medical Center, Kansas City, Kansas.
+ Chalise, Prabhakar. Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas.
+ Parker, William P. Department of Urology, University of Kansas Medical Center, Kansas City, Kansas.
+ Mirza, Moben. Department of Urology, University of Kansas Medical Center, Kansas City, Kansas.
+ Thrasher, Brantley. Department of Urology, University of Kansas Medical Center, Kansas City, Kansas.
+ Gibbs, Heather D. Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas.
+ DiGiovanni, John. Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas.
+ DiGiovanni, John. Center for Molecular Carcinogenesis and Toxicology, The University of Texas at Austin, Austin, Texas.
+ DiGiovanni, John. Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, Texas.
+ Hamilton-Reeves, Jill. Department of Urology, University of Kansas Medical Center, Kansas City, Kansas.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Male
+ Humans
+ *Leptin
+ Prostate
+ Quality of Life
+ Adipose Tissue
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Biomarkers
+ Body Weight
+ Prostatic Neoplasms/th [Therapy]
+ *Prostatic Neoplasms
+ Weight Loss
+Keyword Heading
+ obesity
+ prostate cancer
+ quality-of-life
+ visceral fat
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Excess body and visceral fat increase the risk of death from prostate cancer (PCa). This phase II study aimed to test whether weight reduction by > 5% total body weight counteracts obesity-driven PCa biomarkers.
+
+ MATERIALS AND METHODS: Forty men scheduled for prostatectomy were randomized into intervention (n = 20) or control (n = 20) arms. Intervention participants followed a weight management program for 4 to 16 weeks before and 6 months after surgery. Control participants received standardized educational materials. All participants attended visits at baseline, 1 week before surgery, and 6 months after surgery. Circulating immune cells, cytokines, and chemokines were evaluated. Weight loss, body composition/distribution, quality of life, and nutrition literacy were assessed. Prostate tissue samples obtained from biopsy and surgery were analyzed.
+
+ RESULTS: From baseline to surgery (mean = 5 weeks), the intervention group achieved 5.5% of weight loss (95% CI, 4%-7%). Compared to the control, the intervention also reduced insulin, total cholesterol, LDL cholesterol, leptin, leptin:adiponectin ratio, and visceral adipose tissue. The intervention group had reduced c-peptide, plasminogen-activator-inhibitor-1, and T cell count from baseline to surgery. Myeloid-derived suppressor cells were not statistically different by group. Intervention group anthropometrics improved, including visceral and overall fat loss. No prostate tissue markers changed significantly. Quality of life measures of general and emotional health improved in the intervention group. The intervention group maintained or kept losing to a net loss of 11% initial body weight (95% CI, 8%-14%) at the study end.
+
+ CONCLUSIONS: Our study demonstrated improvements in body composition, PCa biomarkers, and quality of life with a weight management intervention.
+Registry Number/Name of Substance
+ 0 (Leptin). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Clinical Trial, Phase II. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1097%2fJU.0000000000003849
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bechtel&issn=0022-5347&title=Journal+of+Urology&atitle=Impact+of+Weight+Management+on+Obesity-Driven+Biomarkers+of+Prostate+Cancer+Progression.&volume=211&issue=4&spage=552&epage=562&date=2024&doi=10.1097%2FJU.0000000000003849&pmid=38299570&sid=OVID:medline
+
+<112>
+Unique Identifier
+ 38048884
+Title
+ Vernix caseosa reveals mechanistic clues linking maternal obesity to atopic dermatitis pathogenesis.
+Source
+ Journal of Allergy & Clinical Immunology. 153(3):860-867.e1, 2024 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cabalin C; Dibarrart M; Nunez-Rosales JJ; Faunes M; Avaca M; Avalos P; Fabres J; Alvarez-Figueroa MJ; Vera-Kellet C; Silva-Valenzuela S; Saez CG; Borzutzky A
+Authors Full Name
+ Cabalin, Carolina; Dibarrart, Marisol; Nunez-Rosales, Juan Jose; Faunes, Miriam; Avaca, Monica; Avalos, Patricia; Fabres, Jorge; Alvarez-Figueroa, Maria Javiera; Vera-Kellet, Cristian; Silva-Valenzuela, Sergio; Saez, Claudia G; Borzutzky, Arturo.
+Institution
+ Cabalin, Carolina. Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Dibarrart, Marisol. Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Nunez-Rosales, Juan Jose. Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Faunes, Miriam. Department of Neonatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Avaca, Monica. Department of Neonatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Avalos, Patricia. Department of Neonatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Fabres, Jorge. Department of Neonatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Alvarez-Figueroa, Maria Javiera. Department of Pharmacy, Faculty of Chemistry and Pharmacy, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Vera-Kellet, Cristian. Department of Dermatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Silva-Valenzuela, Sergio. Department of Dermatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Saez, Claudia G. Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
+ Borzutzky, Arturo. Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile. Electronic address: aborzutz@uc.cl.
+MeSH Subject Headings
+ Humans
+ Infant, Newborn
+ Female
+ Pregnancy
+ Dermatitis, Atopic/pa [Pathology]
+ *Dermatitis, Atopic
+ Filaggrin Proteins
+ Obesity, Maternal/me [Metabolism]
+ Obesity, Maternal/pa [Pathology]
+ *Obesity, Maternal
+ Vernix Caseosa/me [Metabolism]
+ *Vernix Caseosa
+ Overweight
+ Skin/pa [Pathology]
+ Cytokines/me [Metabolism]
+ Thymic Stromal Lymphopoietin
+ Obesity/pa [Pathology]
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ Atopic dermatitis
+ Staphylococcus epidermidis
+ Staphylococcus hominis
+ dysbiosis
+ filaggrin
+ maternal obesity
+ skin barrier
+ thymic stromal lymphopoietin
+ vernix caseosa
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Maternal overweight and obesity have been associated with an increased risk of atopic dermatitis (AD) in the offspring, but the underlying mechanisms are unclear. Vernix caseosa (VC) is a proteolipid material covering the fetus produced during skin development. However, whether maternal prepregnancy weight excess influences fetal skin development is unknown. Characterizing the VC of newborns from mothers with prepregnancy overweight and obesity might reveal AD-prone alterations during fetal skin development.
+
+ OBJECTIVE: We sought to explore AD biomarkers and staphylococcal loads in VC from the offspring of mothers who were overweight/obese (O/O) before pregnancy versus in those from offspring of normal weight mothers.
+
+ METHODS: The VC of newborns of 14 O/O and 12 normal weight mothers were collected immediately after birth. Biomarkers were determined by ELISA and staphylococcal species by quantitative PCR.
+
+ RESULTS: The VC from the O/O group showed decreased expression of skin barrier proteins (filaggrin and loricrin) and increased levels of proinflammatory biomarkers (IgA, thymic stromal lymphopoietin [TSLP], S100A8, IL-25, and IL-33). No differences in concentrations of antimicrobial peptides and enzymes were detected. The VC from the O/O group had a lower Staphylococcus epidermidis and Staphylococcus hominis commensal bacterial load, whereas Staphylococcus aureus bacterial load was not significantly different between the 2 groups. Maternal body mass index was negatively correlated with VC filaggrin expression and S epidermidis load and was positively associated with TSLP concentration. One-year follow-up established that the offspring of O/O mothers had a higher incidence of AD that was specifically linked with decreased VC filaggrin expression and lower S epidermidis load.
+
+ CONCLUSIONS: VC from neonates of mothers with prepregnancy overweight and obesity exhibit skin barrier molecular alterations and staphylococcal dysbiosis that suggest early mechanistic clues to this population's increased risk of AD. Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Filaggrin Proteins). 0 (Cytokines). GT0IL38SP4 (Thymic Stromal Lymphopoietin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.jaci.2023.09.042
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cabalin&issn=0091-6749&title=Journal+of+Allergy+%26+Clinical+Immunology&atitle=Vernix+caseosa+reveals+mechanistic+clues+linking+maternal+obesity+to+atopic+dermatitis+pathogenesis.&volume=153&issue=3&spage=860&epage=867.e1&date=2024&doi=10.1016%2Fj.jaci.2023.09.042&pmid=38048884&sid=OVID:medline
+
+<113>
+Unique Identifier
+ 38200217
+Title
+ Will obesity break your heart - cardiac biomarkers in the Japan Morning Surge-Home Blood Pressure study.
+Source
+ Hypertension Research - Clinical & Experimental. 47(3):808-810, 2024 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Honemann JN; Jordan J
+Authors Full Name
+ Honemann, Jan-Niklas; Jordan, Jens.
+Institution
+ Honemann, Jan-Niklas. Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care, University of Cologne, Cologne, Germany.
+ Honemann, Jan-Niklas. Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
+ Jordan, Jens. Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany. jens.jordan@dlr.de.
+ Jordan, Jens. Medical Faculty, University of Cologne, Cologne, Germany. jens.jordan@dlr.de.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Humans
+ Blood Pressure/ph [Physiology]
+ Japan
+ Hypertension/pp [Physiopathology]
+ *Hypertension
+ Prognosis
+ Obesity/co [Complications]
+ Biomarkers
+ Phenotype
+Keyword Heading
+ Biomarker
+ Cardiovascular risk
+ Hypertension
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1038%2fs41440-023-01560-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Honemann&issn=0916-9636&title=Hypertension+Research+-+Clinical+%26+Experimental&atitle=Will+obesity+break+your+heart+-+cardiac+biomarkers+in+the+Japan+Morning+Surge-Home+Blood+Pressure+study.&volume=47&issue=3&spage=808&epage=810&date=2024&doi=10.1038%2Fs41440-023-01560-z&pmid=38200217&sid=OVID:medline
+
+<114>
+Unique Identifier
+ 38260144
+Title
+ Metabolic activity of visceral adipose tissue is associated with age-related macular degeneration: a pilot 18F-FDG PET/CT study.
+Source
+ Frontiers in Endocrinology. 14:1322326, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Choi KE; Joung C; Pahk KJ; Kim H; Pahk K
+Authors Full Name
+ Choi, Kwang-Eon; Joung, Chanmin; Pahk, Ki Joo; Kim, Hyunji; Pahk, Kisoo.
+Institution
+ Choi, Kwang-Eon. Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea.
+ Joung, Chanmin. Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
+ Pahk, Ki Joo. Department of Biomedical Engineering, Kyung Hee University, Yongin, Republic of Korea.
+ Kim, Hyunji. Department of Nuclear Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
+ Pahk, Kisoo. Department of Nuclear Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
+MeSH Subject Headings
+ Aged
+ Humans
+ *Fluorodeoxyglucose F18
+ Positron Emission Tomography Computed Tomography
+ Angiogenesis Inhibitors
+ Intra-Abdominal Fat/dg [Diagnostic Imaging]
+ Vascular Endothelial Growth Factor A
+ Visual Acuity
+ *Wet Macular Degeneration
+ Inflammation
+ Obesity/co [Complications]
+ Obesity/dg [Diagnostic Imaging]
+ Biomarkers
+Keyword Heading
+ age-related macular degeneration
+ inflammation
+ obesity
+ positron-emission tomography
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Obesity is known to increase the risk and severity of age-related macular degeneration (AMD). Increased inflamed metabolic activity of visceral adipose tissue (VAT) is considered as a crucial underlying mechanism for the harmful effects of obesity. In this study, we aimed to investigate the inflamed metabolic activity of VAT with 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and their association with AMD.
+
+ Materials and methods: A total of 57 elderly participants (aged >= 50 years) who underwent 18F-FDG PET/CT for health screening and subsequent fundoscopic exam for complaint of recently impaired vision were enrolled. The metabolic activity of VAT was measured from the maximum standardized uptake value (SUVmax) of VAT. The early AMD participant was defined as the participant with either eye satisfying AMD and without any sign of advanced AMD (neovascular AMD or geographic atrophy). The late AMD participant was defined as the participant with either eye satisfying advanced AMD.
+
+ Results: VAT SUVmax was highest in participants with late AMD, intermediate in early AMD, and lowest in non-AMD participants. The levels of systemic inflammation surrogate markers were also highest in late AMD group. Furthermore, VAT SUVmax was positively correlated with systemic inflammation surrogate markers and independently associated with the late AMD.
+
+ Conclusions: The metabolic activity of VAT evaluated by 18F-FDG PET/CT was associated with the severity of AMD and synchronized with the level of systemic inflammation. Thus, VAT SUVmax could be potentially employed as a surrogate marker of obesity-driven VAT inflammation associated with AMD. Copyright © 2024 Choi, Joung, Pahk, Kim and Pahk.
+Registry Number/Name of Substance
+ 0Z5B2CJX4D (Fluorodeoxyglucose F18). 0 (Angiogenesis Inhibitors). 0 (Vascular Endothelial Growth Factor A). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3389%2ffendo.2023.1322326
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Choi&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Metabolic+activity+of+visceral+adipose+tissue+is+associated+with+age-related+macular+degeneration%3A+a+pilot+18F-FDG+PET%2FCT+study.&volume=14&issue=&spage=1322326&epage=&date=2023&doi=10.3389%2Ffendo.2023.1322326&pmid=38260144&sid=OVID:medline
+
+<115>
+Unique Identifier
+ 38087039
+Title
+ Body mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohorts.
+Source
+ British Journal of Cancer. 130(2):308-316, 2024 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fritz J; Jochems SHJ; Bjorge T; Wood AM; Haggstrom C; Ulmer H; Nagel G; Zitt E; Engeland A; Harlid S; Drake I; Stattin P; Stocks T
+Author NameID
+ Fritz, Josef; ORCID: https://orcid.org/0000-0003-1342-3435
+ Bjorge, Tone; ORCID: https://orcid.org/0000-0002-9096-5257
+ Wood, Angela M; ORCID: https://orcid.org/0000-0002-7937-304X
+ Haggstrom, Christel; ORCID: https://orcid.org/0000-0001-6808-4405
+ Ulmer, Hanno; ORCID: https://orcid.org/0000-0001-5911-1002
+ Nagel, Gabriele; ORCID: https://orcid.org/0000-0001-6185-8535
+ Engeland, Anders; ORCID: https://orcid.org/0000-0001-5620-9207
+ Harlid, Sophia; ORCID: https://orcid.org/0000-0001-8540-6891
+ Drake, Isabel; ORCID: https://orcid.org/0000-0002-6500-6310
+ Stocks, Tanja; ORCID: https://orcid.org/0000-0002-0904-0557
+Authors Full Name
+ Fritz, Josef; Jochems, Sylvia H J; Bjorge, Tone; Wood, Angela M; Haggstrom, Christel; Ulmer, Hanno; Nagel, Gabriele; Zitt, Emanuel; Engeland, Anders; Harlid, Sophia; Drake, Isabel; Stattin, Par; Stocks, Tanja.
+Institution
+ Fritz, Josef. Department of Translational Medicine, Lund University, Malmo, Sweden. josef.fritz@med.lu.se.
+ Fritz, Josef. Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria. josef.fritz@med.lu.se.
+ Jochems, Sylvia H J. Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
+ Bjorge, Tone. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
+ Bjorge, Tone. Cancer Registry of Norway, Oslo, Norway.
+ Wood, Angela M. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
+ Haggstrom, Christel. Northern Registry Centre, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Ulmer, Hanno. Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria.
+ Ulmer, Hanno. Agency for Preventive and Social Medicine (aks), Bregenz, Austria.
+ Nagel, Gabriele. Agency for Preventive and Social Medicine (aks), Bregenz, Austria.
+ Nagel, Gabriele. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
+ Zitt, Emanuel. Agency for Preventive and Social Medicine (aks), Bregenz, Austria.
+ Zitt, Emanuel. Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, Austria.
+ Zitt, Emanuel. Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
+ Engeland, Anders. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
+ Engeland, Anders. Department of Chronic Diseases, Norwegian Institute of Public Health, Bergen, Norway.
+ Harlid, Sophia. Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden.
+ Drake, Isabel. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Stattin, Par. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
+ Stocks, Tanja. Department of Translational Medicine, Lund University, Malmo, Sweden.
+ Stocks, Tanja. Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
+MeSH Subject Headings
+ Male
+ Humans
+ Body Mass Index
+ Mediation Analysis
+ *Insulin Resistance
+ *Prostatic Neoplasms
+ Glucose
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Triglycerides
+ Blood Glucose
+ Risk Factors
+ Biomarkers
+Abstract
+ BACKGROUND: Insulin resistance is a hypothesised biological mechanism linking obesity with prostate cancer (PCa) death. Data in support of this hypothesis is limited.
+
+ METHODS: We included 259,884 men from eight European cohorts, with 11,760 incident PCa's and 1784 PCa deaths during follow-up. We used the triglyceride-glucose (TyG) index as indicator of insulin resistance. We analysed PCa cases with follow-up from PCa diagnosis, and the full cohort with follow-up from the baseline cancer-free state, thus incorporating both PCa incidence and death. We calculated hazard ratios (HR) and the proportion of the total effect of body mass index (BMI) on PCa death mediated through TyG index.
+
+ RESULTS: In the PCa-case-only analysis, baseline TyG index was positively associated with PCa death (HR per 1-standard deviation: 1.11, 95% confidence interval (CI); 1.01-1.22), and mediated a substantial proportion of the baseline BMI effect on PCa death (HRtotal effect per 5-kg/m2 BMI: 1.24; 1.14-1.35, of which 28%; 4%-52%, mediated). In contrast, in the full cohort, the TyG index was not associated with PCa death (HR: 1.03; 0.94-1.13), hence did not substantially mediate the effect of BMI on PCa death.
+
+ CONCLUSIONS: Insulin resistance could be an important pathway through which obesity accelerates PCa progression to death. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1038%2fs41416-023-02526-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fritz&issn=0007-0920&title=British+Journal+of+Cancer&atitle=Body+mass+index%2C+triglyceride-glucose+index%2C+and+prostate+cancer+death%3A+a+mediation+analysis+in+eight+European+cohorts.&volume=130&issue=2&spage=308&epage=316&date=2024&doi=10.1038%2Fs41416-023-02526-1&pmid=38087039&sid=OVID:medline
+
+<116>
+Unique Identifier
+ 38405149
+Title
+ Serum amyloid beta 42 levels correlated with metabolic syndrome and its components.
+Source
+ Frontiers in Endocrinology. 15:1278477, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li K; Zhou X; Liu Y; Li D; Li Y; Zhang T; Fu C; Li L; Hu Y; Jiang L
+Authors Full Name
+ Li, Kecheng; Zhou, Xiaoli; Liu, Youren; Li, Dongyu; Li, Yinyin; Zhang, Ting; Fu, Chunyan; Li, Lin; Hu, Yang; Jiang, Li.
+Institution
+ Li, Kecheng. Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Li, Kecheng. Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Zhou, Xiaoli. Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Zhou, Xiaoli. Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Liu, Youren. Department of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
+ Li, Dongyu. Department of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
+ Li, Yinyin. Department of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
+ Zhang, Ting. Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Zhang, Ting. Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Fu, Chunyan. Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Fu, Chunyan. Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Li, Lin. Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Li, Lin. Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Hu, Yang. Department of Gastrointestinal Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Jiang, Li. Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+ Jiang, Li. Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
+MeSH Subject Headings
+ Humans
+ Aged, 80 and over
+ *Metabolic Syndrome
+ Amyloid beta-Peptides
+ Obesity/ep [Epidemiology]
+ *Alzheimer Disease
+ Triglycerides
+ Lipoproteins, HDL
+ Biomarkers
+ Glucose
+Keyword Heading
+ Alzheimer's disease (AD)
+ blood lipids
+ blood pressure
+ body mass index (BMI)
+ metabolic syndrome
+ serum amyloid beta 42 (Abeta42)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction: Beta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer's disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-beta peptides is due to an imbalance between their production and elimination. Previous studies show that diminished levels of CSF amyloid beta 42 (Abeta42) is a biomarker in AD; however, the role of serum Abeta42 in AD is contradictory. BMI and obesity have been reported to be related to increased serum Abeta42 levels. Therefore, we aimed to investigate the relation between metabolic syndrome (MetS), its clinical measures (abdominal obesity, high glucose, high triglyceride, low high-density lipoprotein cholesterol level, and hypertension), and serum Abeta42 levels.
+
+ Methods: A total of 1261 subjects, aged 18-89 years in Chengdu, China, were enrolled from January 2020 to January 2021 to explore the correlation of serum Abeta42 levels with body mass index (BMI), blood lipids, and blood pressure. Furthermore, as the risk of MetS is closely related to age, 1,212 participants (N = 49 with age >= 80 years old were excluded) were analyzed for the correlation of serum Abeta42 level and MetS clinical measures.
+
+ Results: The results showed that log-transformed serum Abeta42 level was positively correlated with BMI (R = 0.29; p < 0.001), log-transformed triglyceride (R = 0.14; p < 0.001), and diastolic blood pressure (DBP) (R = 0.12; p < 0.001) and negatively correlated with high-density lipoprotein (HDL-c) (R = -0.18; p < 0.001). After adjusting for age, sex, and other covariates, elevated serum Abeta42 level was correlated with higher values of BMI (betamodel1 = 2.694, betamodel2 = 2.703) and DBP (betamodel1 = 0.541, betamodel2 = 0.546) but a lower level of HDL-c (betamodel2 = -1.741). Furthermore, serum Abeta42 level was positively correlated with MetS and its clinical measures, including BMI and DBP, and negatively correlated with HDL-c level in the Han Chinese population. However, the level of serum Abeta42 did not show a significant correlation with high glucose or high triglyceride.
+
+ Discussion: These observations indicate that MetS and its components are associated with higher levels of serum Abeta42 and hence limit the potential of serum Abeta42 as a suitable diagnostic biomarker for AD. As such, we recommend serum Abeta42 serve as a direct risk biomarker for MetS rather than for AD. Copyright © 2024 Li, Zhou, Liu, Li, Li, Zhang, Fu, Li, Hu and Jiang.
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Peptides). 0 (Triglycerides). 0 (Lipoproteins, HDL). 0 (Biomarkers). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3389%2ffendo.2024.1278477
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Serum+amyloid+beta+42+levels+correlated+with+metabolic+syndrome+and+its+components.&volume=15&issue=&spage=1278477&epage=&date=2024&doi=10.3389%2Ffendo.2024.1278477&pmid=38405149&sid=OVID:medline
+
+<117>
+Unique Identifier
+ 38327900
+Title
+ Blood nesfatin-1 levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis.
+Source
+ Frontiers in Endocrinology. 14:1275753, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang M; Tong J; Zhu Q; Tang H; Tang L
+Authors Full Name
+ Wang, Mei; Tong, Jiao; Zhu, Qing; Tang, Huaiyun; Tang, Lisha.
+Institution
+ Wang, Mei. Clinical Centre of Reproductive Medicine, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu, China.
+ Tong, Jiao. Clinical Centre of Reproductive Medicine, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu, China.
+ Zhu, Qing. Clinical Centre of Reproductive Medicine, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu, China.
+ Tang, Huaiyun. Clinical Centre of Reproductive Medicine, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu, China.
+ Tang, Lisha. Clinical Centre of Reproductive Medicine, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu, China.
+MeSH Subject Headings
+ Female
+ Humans
+ Biomarkers
+ Ethnicity
+ Obesity
+ *Polycystic Ovary Syndrome
+ Nucleobindins/bl [Blood]
+ *Nucleobindins
+Keyword Heading
+ meta-analysis
+ nesfatin-1
+ polycystic ovary syndrome
+ serum
+ systematic review
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Previous studies have investigated the relationship between nesfatin-1 level and polycystic ovary syndrome (PCOS). However, these studies have produced conflicting results. Thus, in this meta-analysis, we aimed to clarify the association between blood nesfatin-1 levels and PCOS, and the ability of nesfatin-1 as a biomarker in PCOS.
+
+ Methods: Meta-analysis was performed using STATA 12.0 software. We computed standard mean difference (SMD) and 95% confidence interval (CI) regarding the comparison of blood nesfatin-1 in patients with PCOS and controls.
+
+ Results: The present meta-analysis showed no significant difference in blood nesfatin-1 level between patients with PCOS and controls with a random effects model (SMD = 0.03; 95%CI: -0.71, 0.77; I2 = 97.1%, p value for Q test < 0.001). Subgroup analysis for different ethnicities reported no significant difference in blood nesfatin-1 level between patients with PCOS and controls in both Caucasian and Asian populations. Subgroup analysis for different sample types reported no significant difference in serum nesfatin-1 level between patients with PCOS and controls. Subgroup studies reported no significant difference in blood nesfatin-1 level between PCOS and controls in both obese and non-obese populations.
+
+ Conclusion: In conclusion, there is no significant relationship between blood nesfatin-1 levels and PCOS. Copyright © 2024 Wang, Tong, Zhu, Tang and Tang.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (NUCB2 protein, human). 0 (Nucleobindins).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3389%2ffendo.2023.1275753
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Blood+nesfatin-1+levels+in+patients+with+polycystic+ovary+syndrome%3A+a+systematic+review+and+meta-analysis.&volume=14&issue=&spage=1275753&epage=&date=2023&doi=10.3389%2Ffendo.2023.1275753&pmid=38327900&sid=OVID:medline
+
+<118>
+Unique Identifier
+ 38415425
+Title
+ [Natriuretic peptides in the diagnosis and monitoring of heart failure]. [French]
+Original Title
+ Peptides natriuretiques dans le diagnostic et le suivi de l'insuffisance cardiaque.
+Source
+ Revue du Praticien. 74(2):185-193, 2024 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Berthelot E; Eliahou L; Jagu A; Damy T; Hanon O; Hulot JS; Meune C; Roig C; Roubille F; Sabouret P; Logeart D; Mewton N
+Authors Full Name
+ Berthelot, Emmanuelle; Eliahou, Ludivine; Jagu, Annabelle; Damy, Thibaud; Hanon, Olivier; Hulot, Jean-Sebastien; Meune, Christophe; Roig, Clemence; Roubille, Francois; Sabouret, Pierre; Logeart, Damien; Mewton, Nathan.
+Institution
+ Berthelot, Emmanuelle. AP-HP, service de cardiologie, hopital Bicetre, Le Kremlin-Bicetre, France.
+ Eliahou, Ludivine. Centre national de reference pour le syndrome de Marfan et les maladies apparentees, VASCERN HTAD European Reference Centre, AP-HP, hopital Bichat-Claude-Bernard, Paris, France. Service de cardiologie, AP-HP, hopital Bichat-Claude-Bernard, Paris, France.
+ Jagu, Annabelle. Service de cardiologie, groupe hospitalier Paris Saint-Joseph, Paris, France.
+ Damy, Thibaud. Service de cardiologie, Center for Cardiac Amyloidosis, GRC Amyloid Research Institute, DHU A-TVB, AP-HP CHU Henri-Mondor et universite Paris-Est Creteil, France.
+ Hanon, Olivier. EA4468 universite de Paris, service de geriatrie, hopital Broca, AP-HP, Hopitaux universitaires Paris Centre, France.
+ Hulot, Jean-Sebastien. CIC1418 et DMU CARTE, AP-HP, Hopital europeen Georges-Pompidou, Paris, France.
+ Meune, Christophe. Service de cardiologie, hopital Avicenne, AP-HP, universite de Paris, Paris, France.
+ Roig, Clemence. Service de cardiologie, Institut mutualiste Montsouris, Paris, France.
+ Roubille, Francois. INSERM U661, Montpellier, France. hopital Arnaud-de-Villeneuve, universite de Montpellier-1 et 2, Montpellier, France.
+ Sabouret, Pierre. Departement de cardiologie medicale de l'Institut de cardiologie de Paris et College national des cardiologues francais, hopital La Pitie-Salpetriere, universite La Sorbonne, Paris, France.
+ Logeart, Damien. Service de cardiologie, AP-HP, hopital Lariboisiere, Paris, France, universite de Paris, Paris, France.
+ Mewton, Nathan. Hopital cardiovasculaire Louis-Pradel, centre d'investigation clinique INSERM 1407, service insuffisance cardiaque, Hospices civils de Lyon ; universite Claude-Bernard Lyon-1, INSERM U1060 CarMeN, Lyon, France.
+MeSH Subject Headings
+ Humans
+ Reproducibility of Results
+ *Natriuretic Peptides
+ Natriuretic Peptide, Brain
+ Heart Failure/di [Diagnosis]
+ *Heart Failure
+ Prognosis
+ Biomarkers
+ Obesity
+Keyword Heading
+ Heart Failure
+ Natriuretic Peptides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ NATRIURETIC PEPTIDES IN THE DIAGNOSIS AND MONITORING OF CARDIAC FAILURE. Heart failure (HF) is a serious and common disease requiring a prompt diagnosis for appropriate management. Natriuretic peptides, such as BNP and NT-proBNP, play a crucial role in diagnosing HF due to their s pecificity and reproducibility. It is important to measuring natriuretic peptides, especially in cases of acute dyspnea, to differentiate cardiac causes from others. Specific thresholds are recommended, with high values strongly suggest HF, while normal levels rule out the diagnosis. Clinical characteristics, such as age, renal function, atrial fibrillation, obesity, and gender, influence natriuretic peptides levels and should be considered in interpretation. For diabetic, hypertensive, and obese patients, early screening for HF through natriuretic peptides measurement is crucial. Furthermore, these natriuretic peptides are useful for monitoring chronic heart failure patients. They assist in confirming decompensation, titrating treatment, evaluating treatment response, and establishing prognosis. However, it's essential to choose a single biomarker (BNP or NT-proBNP) to avoid confusion.
+Other Abstract
+ Publisher
+ DANS LE DIAGNOSTIC ET LE SUIVI DE L'INSUFFISANCE CARDIAQUE. L'insuffisance cardiaque (IC) est une maladie grave et frequente necessitant un diagnostic rapide pour une prise en charge adequate. Les peptides natriuretiques, tels que le BNP et le NT-proBNP, jouent un role essentiel dans le diagnostic de l'IC en raison de leur specificite et de leur reproductibilite. Il est important de doser les peptides natriuretiques, en particulier lors d'une dyspnee aigue, pour differencier les causes cardiaques des autres. Des seuils specifiques sont recommandes, et des valeurs elevees evoquent fortement une IC, tandis que des taux normaux ecartent le diagnostic. Les caracteristiques cliniques - telles que l'age, la fonction renale, la fibrillation atriale, l'obesite et le sexe - modifient les taux de peptides natriuretiques et doivent etre prises en compte dans l'interpretation. Chez les patients diabetiques, hypertendus et obeses, le depistage precoce de l'IC par le dosage des peptides natriuretiques est crucial. De plus, ces peptides natriuretiques sont utiles pour le suivi des patients insuffisants cardiaques chroniques. Ils aident a confirmer une decompensation, a titrer le traitement, a en evaluer la reponse et a etablir un pronostic. Cependant, il est essentiel de choisir un seul biomarqueur (BNP ou NT-proBNP) pour eviter toute confusion.
+ Language: French
+Registry Number/Name of Substance
+ 0 (Natriuretic Peptides). 114471-18-0 (Natriuretic Peptide, Brain). 0 (Biomarkers).
+Publication Type
+ English Abstract. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=38415425
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Berthelot&issn=0035-2640&title=Revue+du+Praticien&atitle=Peptides+natriuretiques+dans+le+diagnostic+et+le+suivi+de+l%27insuffisance+cardiaque.&volume=74&issue=2&spage=185&epage=193&date=2024&doi=&pmid=38415425&sid=OVID:medline
+
+<119>
+Unique Identifier
+ 38398867
+Title
+ Obesity as a Risk Factor for Complications and Mortality in Individuals with SARS-CoV-2: A Systematic Review.
+Source
+ Nutrients. 16(4), 2024 Feb 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Paula Silva-Lalucci MP; Marques DCS; Valdes-Badilla P; Andreato LV; Magnani Branco BH
+Author NameID
+ Valdes-Badilla, Pablo; ORCID: https://orcid.org/0000-0002-3948-8280
+ Andreato, Leonardo Vidal; ORCID: https://orcid.org/0000-0003-4739-4265
+ Magnani Branco, Braulio Henrique; ORCID: https://orcid.org/0000-0002-4625-9128
+Authors Full Name
+ de Paula Silva-Lalucci, Marielle Priscila; Marques, Deborah Cristina de Souza; Valdes-Badilla, Pablo; Andreato, Leonardo Vidal; Magnani Branco, Braulio Henrique.
+Institution
+ de Paula Silva-Lalucci, Marielle Priscila. Interdisciplinary Laboratory of Intervention in Health Promotion, Cesumar Institute of Science, Technology, and Innovation, Maringa 87050-390, Parana, Brazil.
+ de Paula Silva-Lalucci, Marielle Priscila. Graduate Program in Health Promotion, Cesumar University, Maringa 87050-390, Parana, Brazil.
+ Marques, Deborah Cristina de Souza. Interdisciplinary Laboratory of Intervention in Health Promotion, Cesumar Institute of Science, Technology, and Innovation, Maringa 87050-390, Parana, Brazil.
+ Marques, Deborah Cristina de Souza. Graduate Program in Health Promotion, Cesumar University, Maringa 87050-390, Parana, Brazil.
+ Valdes-Badilla, Pablo. Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile.
+ Valdes-Badilla, Pablo. Sports Coach Career, School of Education, Universidad Vina del Mar, Vina del Mar 2520000, Chile.
+ Andreato, Leonardo Vidal. Higher School of Health Sciences, State University of Amazonas, Manaus 69065-001, Amazonas, Brazil.
+ Magnani Branco, Braulio Henrique. Interdisciplinary Laboratory of Intervention in Health Promotion, Cesumar Institute of Science, Technology, and Innovation, Maringa 87050-390, Parana, Brazil.
+ Magnani Branco, Braulio Henrique. Graduate Program in Health Promotion, Cesumar University, Maringa 87050-390, Parana, Brazil.
+MeSH Subject Headings
+ Adult
+ Humans
+ Biomarkers
+ COVID-19/co [Complications]
+ *COVID-19
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Overweight/co [Complications]
+ Risk Factors
+ *SARS-CoV-2
+Keyword Heading
+ COVID-19
+ clinical laboratory techniques
+ hospitalization
+ overnutrition
+ oxygen inhalation therapy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This systematic review aimed to analyze the available studies that identified overweight and/or obesity as a risk factor for mortality, use of respiratory support, and changes in biochemical markers in adults hospitalized with SARS-CoV-2. The PubMed, Web of Science, and Scopus databases were searched using PRISMA guidelines until January 2024. The protocol was registered with PROSPERO (code: CRD42024501551). Of the 473 articles, only 8 met the inclusion criteria (e.g., adult individuals aged 18 or over diagnosed with COVID-19 individuals with overweight and/or obesity). In addition, the Downs and Black tool was used to assess the quality of the studies. The studies analyzed totaled 9782 adults hospitalized for COVID-19, indicating that overweight and obesity are present in more than half of adults. Diseases such as diabetes mellitus and hypertension are more prevalent in adults with obesity. The systematic review also highlighted that a higher incidence of respiratory support is related to a higher incidence of hospitalization in intensive care units and that adults with overweight and obesity have a higher risk of mortality from COVID-19. Biochemical markers such as procalcitinin, C-reactive protein, and interleukin-6 are associated with the severity of COVID-19 infection. This systematic review exposed overweight and/or obesity as a risk factor for worse COVID-19 disease, as well as for the need for intensive care, respiratory support, mortality, and changes in essential blood markers.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu16040543
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Paula+Silva-Lalucci&issn=2072-6643&title=Nutrients&atitle=Obesity+as+a+Risk+Factor+for+Complications+and+Mortality+in+Individuals+with+SARS-CoV-2%3A+A+Systematic+Review.&volume=16&issue=4&spage=&epage=&date=2024&doi=10.3390%2Fnu16040543&pmid=38398867&sid=OVID:medline
+
+<120>
+Unique Identifier
+ 38398858
+Title
+ Association of a High Healthy Eating Index Diet with Long-Term Visceral Fat Loss in a Large Longitudinal Study.
+Source
+ Nutrients. 16(4), 2024 Feb 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Park S
+Author NameID
+ Park, Sunmin; ORCID: https://orcid.org/0000-0002-6092-8340
+Authors Full Name
+ Park, Sunmin.
+Institution
+ Park, Sunmin. Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan-Si 31499, Republic of Korea.
+MeSH Subject Headings
+ Adult
+ Humans
+ Longitudinal Studies
+ *Diet, Healthy
+ Obesity, Abdominal/ep [Epidemiology]
+ Intra-Abdominal Fat
+ Diet/ae [Adverse Effects]
+ Obesity/pc [Prevention & Control]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/pc [Prevention & Control]
+ *Metabolic Syndrome
+ Waist Circumference
+ Meat
+ Biomarkers
+ Body Mass Index
+Keyword Heading
+ Korean balanced diet
+ abdominal obesity
+ dietary pattern
+ healthy eating index
+ prediction model
+ waist circumference reduction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We aimed to investigate the association of a sustainable diet with a long-term reduction in waist circumference (WC) while identifying novel biomarkers for WC reduction (WCR). The participants were recruited initially during 2004-2013 in a large hospital-based cohort, and the follow-up measurements were conducted during 2012-2016. The 65,611 adults aged 45-75 were categorized into WC-loss (n = 22,290) and WC-gain (n = 43,321). Each study investigated demographic, anthropometric, biochemical, genetic, and dietary factors. The modified Healthy Eating Index (MHEI), dietary patterns, and glycemic index were calculated from a validated semi-quantitative food frequency questionnaire. Novel biomarkers influencing WC reduction were identified using machine learning approaches. A WCR was inversely associated with metabolic syndrome (MetS) risk and its components. Daily energy intake did not differ between those with and without WCR. However, MHEI, which represents diet quality, demonstrated a positive association with WCR. Among various dietary patterns, the Asian-style balanced diet (ABD), including more fermented soybeans and less restricted salt than the Diet Approach to Stop Hypertension, was positively associated with WCR. However, an inverse association was observed between the diet that was high in noodle and processed meat consumption and that which was high in rice consumption. However, the PRS for abdominal obesity did not significantly interrupt WCR. The receiver operating characteristic curve in the prediction model for WCR was about 0.86. The biomarkers in the models included MetS components, inflammation index, diet components, alcohol consumption, and smoking status, but not genetic factors. In conclusion, adopting a high-quality diet with a high MHEI like ABD leads to WCR, irrespective of genetic influences. These results could be applied to develop effective strategies for preventing and managing abdominal obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu16040534
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Park&issn=2072-6643&title=Nutrients&atitle=Association+of+a+High+Healthy+Eating+Index+Diet+with+Long-Term+Visceral+Fat+Loss+in+a+Large+Longitudinal+Study.&volume=16&issue=4&spage=&epage=&date=2024&doi=10.3390%2Fnu16040534&pmid=38398858&sid=OVID:medline
+
+<121>
+Unique Identifier
+ 38378519
+Title
+ High prevalence of fatty liver and its association with metabolic syndrome among rural adults with chronic hepatitis C: Implications for primary healthcare.
+Source
+ BMC Public Health. 24(1):532, 2024 Feb 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang TJ; Chen MY; Lin YC; Chiu WN; Huang TJ; Weng HH
+Authors Full Name
+ Wang, Ta-Jen; Chen, Mei-Yen; Lin, Yu-Chih; Chiu, Wen-Nan; Huang, Tung-Jung; Weng, Hsu-Huei.
+Institution
+ Wang, Ta-Jen. Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
+ Chen, Mei-Yen. Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan.
+ Chen, Mei-Yen. Department of Cardiology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
+ Chen, Mei-Yen. School of Nursing, Chang Gung University, Taoyuan, Taiwan.
+ Lin, Yu-Chih. Department of Family Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
+ Chiu, Wen-Nan. Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
+ Huang, Tung-Jung. Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
+ Huang, Tung-Jung. Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan.
+ Weng, Hsu-Huei. Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan. hweng@post.harvard.edu.
+ Weng, Hsu-Huei. Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan. hweng@post.harvard.edu.
+ Weng, Hsu-Huei. College of Medicine, Chang Gung University, Taoyuan, Taiwan. hweng@post.harvard.edu.
+MeSH Subject Headings
+ Adult
+ Humans
+ Child
+ *Metabolic Syndrome
+ Hepatitis C, Chronic/co [Complications]
+ Hepatitis C, Chronic/ep [Epidemiology]
+ Hepatitis C, Chronic/di [Diagnosis]
+ *Hepatitis C, Chronic
+ Risk Factors
+ Prevalence
+ Blood Glucose
+ Cross-Sectional Studies
+ Fatty Liver/dg [Diagnostic Imaging]
+ Fatty Liver/ep [Epidemiology]
+ *Fatty Liver
+ Obesity/ep [Epidemiology]
+ *Diabetes Mellitus
+ Hypertension/co [Complications]
+ *Hypertension
+ Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases
+ Biomarkers
+ Cholesterol
+ *Liver Neoplasms
+ Lipoproteins, HDL
+ Primary Health Care
+Keyword Heading
+ Cardiometabolic diseases
+ Chronic hepatitis C
+ Fatty liver
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Chronic hepatitis C (CHC) virus infection is a global health concern that is associated with significant liver-related morbidity and mortality. Owing to the inflammatory pathway, CHC can causefatty liver, liver cirrhosis, and liver cancer and is associated with cardiometabolic diseases, such as hypertension and diabetes. Fatty liver is associated with metabolic disorders, cardiovascular diseases, diabetes, and liver cancer. Hence, the early detection of fatty liver through noninvasive screening in adults with CHC is important in primary healthcare settings. This study aimed to explore the prevalence of fatty liver and its association with metabolic syndrome amongrural adults with CHC.
+
+ METHODS: This was a series of cohort studies related to the elimination of the CHC burden around the western coastal Yunlin County, Taiwan, between August 2018 and July 2021. A cross-sectional study was conducted after hepatitis C virus RNA confirmation in a hepatitis C- endemic area. A gastrointestinal physician or radiologist assessed fatty liver by ultrasonography. Fatty liver was classified into four grades: normal, mild, moderate, and severe. Three liver enzyme biomarkers were identified. According to the Taiwan national standard, metabolic syndrome was defined based on the presence of three or more of the five abnormal biomarkers, including increased waist circumference, elevated blood pressure, elevated fasting blood glucose level, elevated triglyceride level, and low high-density lipoprotein cholesterol level.
+
+ RESULTS: A total of 256 rural adults with CHC were enrolled. The mean age of the participants was 67.5 (standard deviation = 11.8) years, with a low educational level. High prevalence of fatty liver (79%), central obesity (54.3%), elevated blood pressure (55.5%),elevated fasting blood glucose (FBG) level (44.9%), and metabolic syndrome (37.9%) were observed. The results showed that adults with CHC with moderate to severe fatty liver were significantly associated with an increased risk of increased waist circumference (P < 0.001), increased blood pressure (P < 0.001), low high-density lipoprotein cholesterol level (P < 0.05), and elevated liver enzyme biomarker levels (all P < 0.05) after adjusting for age, sex, and educational level. Furthermore, adults with CHC with moderate to severe fatty liver were significantly associated with a greater risk of metabolic syndrome (odds ratio = 2.85, 95% confidence interval = 1.66 to 4.92).
+
+ CONCLUSIONS: The findings demonstrate a high prevalence of fatty liver in rural adults with CHC, which is significantly associated with obesity, metabolic syndrome, and elevated liver biomarker levels. Clinicians and primary healthcare providers must encourage patients with CHC to receive antiviral therapy combined with weight loss management and lifestyle modification, allowing general improvements in their liver and cardiometabolic health. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Blood Glucose). 0 (Biomarkers). 97C5T2UQ7J (Cholesterol). 0 (Lipoproteins, HDL).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12889-024-17851-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1471-2458&title=BMC+Public+Health&atitle=High+prevalence+of+fatty+liver+and+its+association+with+metabolic+syndrome+among+rural+adults+with+chronic+hepatitis+C%3A+Implications+for+primary+healthcare.&volume=24&issue=1&spage=532&epage=&date=2024&doi=10.1186%2Fs12889-024-17851-0&pmid=38378519&sid=OVID:medline
+
+<122>
+Unique Identifier
+ 38213254
+Title
+ Differences in vascular endothelial function and serum proteome between obese people with phlegm-dampness constitution and balanced constitution.
+Source
+ Journal of Traditional Chinese Medicine. 44(1):188-196, 2024 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Linghui Z; Ziwei S; Yuanyuan G; Meiyi L; Yi Z; Ruoxi YU; Qi W; Lingru LI
+Authors Full Name
+ Linghui, Zhu; Ziwei, Sun; Yuanyuan, Guan; Meiyi, Liu; Yi, Zheng; Ruoxi, Y U; Qi, Wang; Lingru, L I.
+Institution
+ Linghui, Zhu. School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
+ Ziwei, Sun. National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
+ Yuanyuan, Guan. School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
+ Meiyi, Liu. School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
+ Yi, Zheng. School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
+ Ruoxi, Y U. National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
+ Qi, Wang. National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
+ Lingru, L I. National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
+MeSH Subject Headings
+ Humans
+ *Medicine, Chinese Traditional
+ Proteome/ge [Genetics]
+ Interleukin-33
+ Obesity
+ *Cardiovascular Diseases
+ Biomarkers
+ Blood Proteins
+ Forkhead Transcription Factors
+Keyword Heading
+ obesity
+ phlegm-dampness constitution
+ proteome
+ reactive hyperemia index
+ vascular endothelial function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To evaluate the extent of vascular endothelial dysfunction and preliminary identify serum protein biomarkers associated with obese individuals at risk for cardiovascular disease (CVD).
+
+ METHODS: Fifteen obese volunteers with the phlegm-dampness constitution or balanced constitution were recruited for this study respectively. The clinical baseline data was collected, and the vascular endothelial function was evaluated using the EndoPATTM. Blood samples were collected for the serum proteome analysis. The differences in the serum protein expression levels between the two groups were detected and the protein interaction network analysis, correlation analysis, receiver operating characteristic (ROC) curve analysis, and random forest model investigation were conducted.
+
+ RESULTS: There were no statistical differences found in the baseline data. For vascular endothelial function, the reactive hyperemia index (RHI) of the phlegm-dampness constitution obese group was significantly lower than that of the balanced constitution obese group (1.46 +/- 0.30 vs 2.82 +/- 0.78, P < 0.0001), indicating vascular endothelial dysfunction. There are 66 differentially expressed serum proteins between the two groups. apolipoprotein A2 (ApoA2), angiotensin-converting enzyme 2 (ACE-2), interleukin-33 (IL-33), and forkhead box P3 (FoxP3) showed significant differences and area under curve values of their ROC curves were greater than 0.7 and correlated significantly with RHI.
+
+ CONCLUSION: Vascular endothelial dysfunction was present in the phlegm-dampness constitution obese group. Thus, alterations in the expression levels of key serum proteins, including ApoA2, ACE-2, IL-33, and FoxP3 could serve as potential biomarkers in the obese population at risk of CVD.
+Registry Number/Name of Substance
+ 0 (Proteome). 0 (Interleukin-33). 0 (Biomarkers). 0 (Blood Proteins). 0 (Forkhead Transcription Factors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.19852%2fj.cnki.jtcm.20231110.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Linghui&issn=0255-2922&title=Journal+of+Traditional+Chinese+Medicine&atitle=Differences+in+vascular+endothelial+function+and+serum+proteome+between+obese+people+with+phlegm-dampness+constitution+and+balanced+constitution.&volume=44&issue=1&spage=188&epage=196&date=2024&doi=10.19852%2Fj.cnki.jtcm.20231110.005&pmid=38213254&sid=OVID:medline
+
+<123>
+Unique Identifier
+ 38095878
+Title
+ Atezolizumab in Combination With Carboplatin and Survival Outcomes in Patients With Metastatic Triple-Negative Breast Cancer: The TBCRC 043 Phase 2 Randomized Clinical Trial.
+Source
+ JAMA Oncology. 10(2):193-201, 2024 Feb 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lehmann BD; Abramson VG; Dees EC; Shah PD; Ballinger TJ; Isaacs C; Santa-Maria CA; An H; Gonzalez-Ericsson PI; Sanders ME; Newsom KC; Abramson RG; Sheng Q; Hsu CY; Shyr Y; Wolff AC; Pietenpol JA
+Authors Full Name
+ Lehmann, Brian D; Abramson, Vandana G; Dees, E Claire; Shah, Payal D; Ballinger, Tarah J; Isaacs, Claudine; Santa-Maria, Cesar A; An, Hanbing; Gonzalez-Ericsson, Paula I; Sanders, Melinda E; Newsom, Kimberly C; Abramson, Richard G; Sheng, Quanhu; Hsu, Chih-Yuan; Shyr, Yu; Wolff, Antonio C; Pietenpol, Jennifer A.
+Institution
+ Lehmann, Brian D. Department of Medicine, Vanderbilt University, Nashville, Tennessee.
+ Lehmann, Brian D. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Tennessee.
+ Abramson, Vandana G. Department of Medicine, Vanderbilt University, Nashville, Tennessee.
+ Abramson, Vandana G. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Tennessee.
+ Dees, E Claire. Department of Medicine and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill.
+ Shah, Payal D. Department of Medicine, University of Pennsylvania, Philadelphia.
+ Ballinger, Tarah J. Department of Medicine, Indiana University, Indianapolis.
+ Isaacs, Claudine. Department of Medical Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC.
+ Santa-Maria, Cesar A. Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
+ An, Hanbing. Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee.
+ Gonzalez-Ericsson, Paula I. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Tennessee.
+ Gonzalez-Ericsson, Paula I. Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.
+ Sanders, Melinda E. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Tennessee.
+ Sanders, Melinda E. Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee.
+ Newsom, Kimberly C. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Tennessee.
+ Abramson, Richard G. Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, Tennessee.
+ Sheng, Quanhu. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
+ Sheng, Quanhu. Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
+ Hsu, Chih-Yuan. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
+ Hsu, Chih-Yuan. Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
+ Shyr, Yu. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
+ Shyr, Yu. Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
+ Wolff, Antonio C. Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
+ Pietenpol, Jennifer A. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Tennessee.
+ Pietenpol, Jennifer A. Department of Biochemistry, Vanderbilt University, Nashville, Tennessee.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Humans
+ Female
+ Middle Aged
+ Aged
+ Male
+ Carboplatin/tu [Therapeutic Use]
+ Triple Negative Breast Neoplasms/pa [Pathology]
+ *Triple Negative Breast Neoplasms
+ B7-H1 Antigen/im [Immunology]
+ Blood Glucose
+ Ligands
+ Antineoplastic Combined Chemotherapy Protocols/ae [Adverse Effects]
+ Biomarkers
+ Disease Progression
+ Obesity
+ Apoptosis
+ *Antibodies, Monoclonal, Humanized
+Abstract
+ Importance: Agents targeting programmed death ligand 1 (PD-L1) have demonstrated efficacy in triple-negative breast cancer (TNBC) when combined with chemotherapy and are now the standard of care in patients with PD-L1-positive metastatic disease. In contrast to microtubule-targeting agents, the effect of combining platinum compounds with programmed cell death 1 (PD-1)/PD-L1 immunotherapy has not been extensively determined.
+
+ Objective: To evaluate the efficacy of atezolizumab with carboplatin in patients with metastatic TNBC.
+
+ Design, Setting, and Participants: This phase 2 randomized clinical trial was conducted in 6 centers from August 2017 to June 2021.
+
+ Interventions: Patients with metastatic TNBC were randomized to receive carboplatin area under the curve (AUC) 6 alone or with atezolizumab, 1200 mg, every 3 weeks until disease progression or unacceptable toxic effects with a 3-year duration of follow-up.
+
+ Main Outcome and Measures: The primary end point was investigator-assessed progression-free survival (PFS). Secondary end points included overall response rate (ORR), clinical benefit rate (CBR), and overall survival (OS). Other objectives included correlation of response with tumor PD-L1 levels, tumor-infiltrating lymphocytes (TILs), tumor DNA- and RNA-sequenced biomarkers, TNBC subtyping, and multiplex analyses of immune markers.
+
+ Results: All 106 patients with metastatic TNBC who were enrolled were female with a mean (range) age of 55 (27-79) years, of which 12 (19%) identified as African American/Black, 1 (1%) as Asian, 73 (69%) as White, and 11 (10%) as unknown. Patients were randomized and received either carboplatin (n = 50) or carboplatin and atezolizumab (n = 56). The combination improved PFS (hazard ratio [HR], 0.66; 95% CI, 0.44-1.01; P = .05) from a median of 2.2 to 4.1 months, increased ORR from 8.0% (95% CI, 3.2%-18.8%) to 30.4% (95% CI, 19.9%-43.3%), increased CBR at 6 months from 18.0% (95% CI, 9.8%-30.1%) to 37.5% (95% CI, 26.0%-50.6%), and improved OS (HR, 0.60; 95% CI, 0.37-0.96; P = .03) from a median of 8.6 to 12.6 months. Subgroup analysis showed PD-L1-positive tumors did not benefit more from adding atezolizumab (HR, 0.62; 95% CI, 0.23-1.65; P = .35). Patients with high TILs (HR, 0.12; 95% CI, 0.30-0.50), high mutation burden (HR, 0.50; 95% CI, 0.23-1.06), and prior chemotherapy (HR, 0.59; 95% CI, 0.36-0.95) received greater benefit on the combination. Patients with obesity and patients with more than 125 mg/dL on-treatment blood glucose levels were associated with better PFS (HR, 0.35; 95% CI, 0.10-1.80) on the combination. TNBC subtypes benefited from adding atezolizumab, except the luminal androgen receptor subtype.
+
+ Conclusions and Relevance: In this randomized clinical trial, the addition of atezolizumab to carboplatin significantly improved survival of patients with metastatic TNBC regardless of PD-L1 status. Further, lower risk of disease progression was associated with increased TILs, higher mutation burden, obesity, and uncontrolled blood glucose levels.
+
+ Trial Registration: ClinicalTrials.gov Identifier: NCT03206203.
+Registry Number/Name of Substance
+ BG3F62OND5 (Carboplatin). 52CMI0WC3Y (atezolizumab). 0 (B7-H1 Antigen). 0 (Blood Glucose). 0 (Ligands). 0 (Biomarkers). 0 (Antibodies, Monoclonal, Humanized).
+Publication Type
+ Journal Article. Comment.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1001%2fjamaoncol.2023.5424
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lehmann&issn=2374-2437&title=JAMA+Oncology&atitle=Atezolizumab+in+Combination+With+Carboplatin+and+Survival+Outcomes+in+Patients+With+Metastatic+Triple-Negative+Breast+Cancer%3A+The+TBCRC+043+Phase+2+Randomized+Clinical+Trial.&volume=10&issue=2&spage=193&epage=201&date=2024&doi=10.1001%2Fjamaoncol.2023.5424&pmid=38095878&sid=OVID:medline
+
+<124>
+Unique Identifier
+ 38337650
+Title
+ Daily Consumption of Golden Berry (Physalis peruviana) Has Been Shown to Halt the Progression of Insulin Resistance and Obesity in Obese Rats with Metabolic Syndrome.
+Source
+ Nutrients. 16(3), 2024 Jan 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Angel-Martin A; Vaillant F; Moreno-Castellanos N
+Author NameID
+ Angel-Martin, Alberto; ORCID: https://orcid.org/0000-0001-5094-2926
+ Vaillant, Fabrice; ORCID: https://orcid.org/0000-0001-6318-1353
+ Moreno-Castellanos, Natalia; ORCID: https://orcid.org/0000-0003-2481-3164
+Authors Full Name
+ Angel-Martin, Alberto; Vaillant, Fabrice; Moreno-Castellanos, Natalia.
+Institution
+ Angel-Martin, Alberto. Observatorio Epidemiologico de Nutricion y Enfermedades Cronicas, Nutrition School, Health Faculty, Universidad Industrial de Santander, Cra 32 # 29-31, Bucaramanga 680002, Colombia.
+ Vaillant, Fabrice. Colombian Corporation for Agricultural Research-Agrosavia, La Selva Research Center, Kilometer 7, Via a Las Palmas, Vereda Llanogrande, Rionegro 054048, Colombia.
+ Vaillant, Fabrice. French Center for Agricultural Research for International Development (CIRAD), UMR Qualisud, 34398 Montpellier, France.
+ Moreno-Castellanos, Natalia. Centro de Investigacion en Ciencia y Tecnologia de Alimentos, Department of Basic Sciences, Medicine School, Health Faculty, Universidad Industrial de Santander, Cra 27 calle 9, Bucaramanga 680002, Colombia.
+MeSH Subject Headings
+ Animals
+ Humans
+ Rats
+ Biomarkers
+ Blood Glucose/me [Metabolism]
+ Chronic Disease
+ *Diabetes Mellitus, Type 2
+ Diet, High-Fat
+ Fruit/me [Metabolism]
+ *Fruit
+ Insulin
+ *Insulin Resistance
+ *Metabolic Syndrome
+ Obesity/me [Metabolism]
+ *Physalis
+Keyword Heading
+ Golden Berry (Physalis peruviana)
+ insulin resistance
+ metabolic syndrome
+ nutritional intervention
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In a study addressing the high risk of chronic diseases in people with diabetes and obesity linked to metabolic syndrome, the impact of a Golden Berry diet was investigated using a diabetic animal model. Obese rats with diabetic characteristics were fed a diet containing five percent Golden Berry for 16 days. This study focused on various parameters including organ weights, expression of metabolic genes, and urinary biomarkers. Post-Golden Berry intake, there was a notable decrease in the body, liver, pancreas, visceral, and subcutaneous adipose tissue weights in these obese, hyperglycemic rats. In contrast, an increase in brown adipose tissue (BAT) cell mass was observed. This diet also resulted in reduced blood glucose levels and normalized plasma biochemical profiles, including cholesterol, triglycerides, LDL, and HDL levels. Additionally, it modulated specific urinary biomarkers, particularly pipe-colic acid, a primary marker for type 2 diabetes. Bioinformatics analysis linked these dietary effects to improved insulin signaling and adipogenesis. Regular consumption of Golden Berry effectively prevented insulin resistance and obesity in rats, underscoring its significant health benefits and the protective role of an antioxidant-rich diet against metabolic syndrome. These findings offer promising insights for future therapeutic strategies to manage and prevent obesity and related chronic diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu16030365
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Angel-Martin&issn=2072-6643&title=Nutrients&atitle=Daily+Consumption+of+Golden+Berry+%28Physalis+peruviana%29+Has+Been+Shown+to+Halt+the+Progression+of+Insulin+Resistance+and+Obesity+in+Obese+Rats+with+Metabolic+Syndrome.&volume=16&issue=3&spage=&epage=&date=2024&doi=10.3390%2Fnu16030365&pmid=38337650&sid=OVID:medline
+
+<125>
+Unique Identifier
+ 38316601
+Title
+ Fibre-rich Foods to Treat Obesity and Prevent Colon Cancer trial study protocol: a randomised clinical trial of fibre-rich legumes targeting the gut microbiome, metabolome and gut transit time of overweight and obese patients with a history of noncancerous adenomatous polyps.
+Source
+ BMJ Open. 14(2):e081379, 2024 02 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hartman TJ; Christie J; Wilson A; Ziegler TR; Methe B; Flanders WD; Rolls BJ; Loye Eberhart B; Li JV; Huneault H; Cousineau B; Perez MR; O'Keefe SJD
+Author NameID
+ Hartman, Terryl J; ORCID: https://orcid.org/0000-0001-5942-3161
+ Wilson, Annette; ORCID: https://orcid.org/0000-0002-7426-1786
+ Rolls, Barbara J; ORCID: https://orcid.org/0000-0003-2374-1517
+ Loye Eberhart, Blaine; ORCID: https://orcid.org/0000-0002-6239-0053
+ Li, Jia V; ORCID: https://orcid.org/0000-0002-5763-6670
+ Huneault, Helaina; ORCID: https://orcid.org/0000-0003-3866-2387
+ Cousineau, Ben; ORCID: https://orcid.org/0000-0001-8732-2835
+ Perez, Miriam R; ORCID: https://orcid.org/0000-0002-2432-4603
+Authors Full Name
+ Hartman, Terryl J; Christie, Jennifer; Wilson, Annette; Ziegler, Thomas R; Methe, Barbara; Flanders, William Dana; Rolls, Barbara J; Loye Eberhart, Blaine; Li, Jia V; Huneault, Helaina; Cousineau, Ben; Perez, Miriam R; O'Keefe, Stephen J D.
+Institution
+ Hartman, Terryl J. Department of Epidemiology, Rollins School of Public Health and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA tjhartm@emory.edu.
+ Hartman, Terryl J. Nutrition and Health Sciences, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
+ Christie, Jennifer. Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
+ Wilson, Annette. Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
+ Ziegler, Thomas R. Department of Medicine, Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia, USA.
+ Methe, Barbara. Pulmonary, Allergy and Critical Care Medicine, Center for the Microbiome and Medicine, University of Pittsburg, Pittsburgh, Pennsylvania, USA.
+ Flanders, William Dana. Department of Biostatistics and Bioinformatics, Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
+ Rolls, Barbara J. Department of Nutritional Sciences, The Pennsylvania State University, State College, Pennsylvania, USA.
+ Loye Eberhart, Blaine. Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
+ Li, Jia V. Section of Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Commonwealth Building, Hammersmith Hospital Campus, Imperial College London, South Kensington, London, UK.
+ Huneault, Helaina. Nutrition and Health Sciences, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
+ Cousineau, Ben. Nutrition and Health Sciences, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
+ Perez, Miriam R. Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
+ O'Keefe, Stephen J D. Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
+MeSH Subject Headings
+ Adult
+ Humans
+ Overweight/co [Complications]
+ Overweight/th [Therapy]
+ *Gastrointestinal Microbiome
+ *Fabaceae
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Colonic Neoplasms/pc [Prevention & Control]
+ *Colonic Neoplasms
+ Adenomatous Polyps/co [Complications]
+ *Adenomatous Polyps
+ Vegetables
+ Metabolome
+ Biomarkers
+ Randomized Controlled Trials as Topic
+Keyword Heading
+ GASTROENTEROLOGY
+ NUTRITION & DIETETICS
+ ONCOLOGY
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Recently published studies support the beneficial effects of consuming fibre-rich legumes, such as cooked dry beans, to improve metabolic health and reduce cancer risk. In participants with overweight/obesity and a history of colorectal polyps, the Fibre-rich Foods to Treat Obesity and Prevent Colon Cancer randomised clinical trial will test whether a high-fibre diet featuring legumes will simultaneously facilitate weight reduction and suppress colonic mucosal biomarkers of colorectal cancer (CRC).
+
+ METHODS/DESIGN: This study is designed to characterise changes in (1) body weight; (2) biomarkers of insulin resistance and systemic inflammation; (3) compositional and functional profiles of the faecal microbiome and metabolome; (4) mucosal biomarkers of CRC risk and (5) gut transit. Approximately 60 overweight or obese adults with a history of noncancerous adenomatous polyps within the previous 3 years will be recruited and randomised to one of two weight-loss diets. Following a 1-week run-in, participants in the intervention arm will receive preportioned high-fibre legume-rich entrees for two meals/day in months 1-3 and one meal/day in months 4-6. In the control arm, entrees will replace legumes with lean protein sources (eg, chicken). Both groups will receive in-person and written guidance to include nutritionally balanced sides with energy intake to lose 1-2 pounds per week.
+
+ ETHICS AND DISSEMINATION: The National Institutes of Health fund this ongoing 5-year study through a National Cancer Institute grant (5R01CA245063) awarded to Emory University with a subaward to the University of Pittsburgh. The study protocol was approved by the Emory Institutional Review Board (IRB approval number: 00000563).
+
+ TRIAL REGISTRATION NUMBER: NCT04780477. Copyright © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial Protocol. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1136%2fbmjopen-2023-081379
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hartman&issn=2044-6055&title=BMJ+Open&atitle=Fibre-rich+Foods+to+Treat+Obesity+and+Prevent+Colon+Cancer+trial+study+protocol%3A+a+randomised+clinical+trial+of+fibre-rich+legumes+targeting+the+gut+microbiome%2C+metabolome+and+gut+transit+time+of+overweight+and+obese+patients+with+a+history+of+noncancerous+adenomatous+polyps.&volume=14&issue=2&spage=e081379&epage=&date=2024&doi=10.1136%2Fbmjopen-2023-081379&pmid=38316601&sid=OVID:medline
+
+<126>
+Unique Identifier
+ 38296579
+Title
+ Influence of Body Mass Index on the Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Level in Chinese Patients with Heart Failure.
+Source
+ International Heart Journal. 65(1):47-54, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tian L; Li X; Zhang J; Tian X; Wan X; Yao D; Luo B; Huang Q; Deng Y; Xiang W
+Authors Full Name
+ Tian, Lingfang; Li, Xiangkui; Zhang, Jian; Tian, Xinhui; Wan, Xiaolei; Yao, Dengju; Luo, Bin; Huang, Qinzhen; Deng, Yansong; Xiang, Wei.
+Institution
+ Tian, Lingfang. Key Laboratory of Electronic and Information Engineering, State Ethnic Affairs Commission, Southwest Minzu University.
+ Li, Xiangkui. School of Computer Science and Technology, Harbin University of Science and Technology.
+ Zhang, Jian. West China Biomedical Big Data Center, West China Hospital, Sichuan University.
+ Tian, Xinhui. Key Laboratory of Electronic and Information Engineering, State Ethnic Affairs Commission, Southwest Minzu University.
+ Wan, Xiaolei. Key Laboratory of Electronic and Information Engineering, State Ethnic Affairs Commission, Southwest Minzu University.
+ Yao, Dengju. School of Computer Science and Technology, Harbin University of Science and Technology.
+ Luo, Bin. Sichuan Huhui Software CO.,LTD.
+ Huang, Qinzhen. Key Laboratory of Electronic and Information Engineering, State Ethnic Affairs Commission, Southwest Minzu University.
+ Deng, Yansong. Key Laboratory of Electronic and Information Engineering, State Ethnic Affairs Commission, Southwest Minzu University.
+ Xiang, Wei. Key Laboratory of Electronic and Information Engineering, State Ethnic Affairs Commission, Southwest Minzu University.
+MeSH Subject Headings
+ Humans
+ Prognosis
+ *Natriuretic Peptide, Brain
+ Body Mass Index
+ Overweight/co [Complications]
+ Retrospective Studies
+ Thinness
+ Obesity/co [Complications]
+ Biomarkers
+ Peptide Fragments
+ Heart Failure/co [Complications]
+ Heart Failure/di [Diagnosis]
+ *Heart Failure
+Keyword Heading
+ Adverse events prediction
+ BMI-NT-proBNP correlation
+ NT-proBNP thresholds
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an essential biomarker for the prediction of heart failure (HF), but its prognostic ability across body mass index (BMI) categories needs to be clarified. Our study aimed to explore the association between BMI and NT-proBNP and assess the effect of BMI on the prognostic ability of NT-proBNP in Chinese patients with HF. We retrospectively analyzed clinical data from the FuWai Hospital HF Center in Beijing, China. According to the Chinese adult BMI standard, 1,508 patients with HF were classified into four groups: underweight (BMI < 18.5 kg/m2), normal weight (BMI 18.5-23.9 kg/m2, as a reference category), overweight (BMI 24-27.9 kg/m2), and obesity (BMI >= 28 kg/m2). NT-proBNP was examined for its prognostic role in adverse events as an endpoint. BMI was independently and negatively associated with NT-proBNP (beta = -0.074; P < 0.001), and NT-proBNP levels tended to decrease as BMI increased across the different BMI categories. The results of our study differ from those of other studies of European-American populations. In this study, NT-proBNP was a weak predictor of a 4-year adverse prognosis in underweight patients (BMI < 18.5 kg/m2). In other BMI categories, NT-proBNP was an independent predictor of adverse events in HF. BMI and sex significantly affected the optimal threshold for NT-proBNP to predict the risk of adverse events. There is a negative correlation between BMI and NT-proBNP, and NT-proBNP independently predicts adverse HF events in patients with a BMI of >= 18.5 kg/m2. The optimal risk prediction cutoffs are lower in patients who are overweight and obese.
+Registry Number/Name of Substance
+ 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain). 0 (Biomarkers). 0 (Peptide Fragments).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1536%2fihj.23-461
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tian&issn=1349-2365&title=International+Heart+Journal&atitle=Influence+of+Body+Mass+Index+on+the+Prognostic+Value+of+N-Terminal+Pro-B-Type+Natriuretic+Peptide+Level+in+Chinese+Patients+with+Heart+Failure.&volume=65&issue=1&spage=47&epage=54&date=2024&doi=10.1536%2Fihj.23-461&pmid=38296579&sid=OVID:medline
+
+<127>
+Unique Identifier
+ 36443558
+Title
+ The Symbiosis Between Lactobacillus acidophilus and Inulin: Metabolic Benefits in an Obese Murine Model.
+Source
+ Probiotics & Antimicrobial Proteins. 16(1):26-34, 2024 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rangel-Torres BE; Garcia-Montoya IA; Rodriguez-Tadeo A; Jimenez-Vega F
+Authors Full Name
+ Rangel-Torres, Brian Eduardo; Garcia-Montoya, Isui Abril; Rodriguez-Tadeo, Alejandra; Jimenez-Vega, Florinda.
+Institution
+ Rangel-Torres, Brian Eduardo. Departamento Ciencias Quimico-Biologicas, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Ciudad Juarez, Mexico.
+ Garcia-Montoya, Isui Abril. Departamento Ciencias Quimico-Biologicas, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Ciudad Juarez, Mexico.
+ Rodriguez-Tadeo, Alejandra. Departamento de Ciencias de La Salud, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Ciudad Juarez, Mexico.
+ Jimenez-Vega, Florinda. Departamento Ciencias Quimico-Biologicas, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Ciudad Juarez, Mexico. fjimenez@uacj.mx.
+MeSH Subject Headings
+ Mice
+ Animals
+ *Lactobacillus acidophilus
+ Inulin/me [Metabolism]
+ Obesity
+ Diet, Reducing
+ Cholesterol, LDL/me [Metabolism]
+ Symbiosis
+ Disease Models, Animal
+ Probiotics/pd [Pharmacology]
+ *Probiotics
+ Prebiotics
+ Cholesterol/me [Metabolism]
+ Triglycerides
+ Glucose/me [Metabolism]
+ Biomarkers
+Keyword Heading
+ Inulin
+ L. acidophilus
+ Obesity
+ Prebiotics
+ Probiotics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is defined as having an excess of adipose tissue and is associated with the development of diabetes, hypertension, and atherosclerosis, which are the main causes of death worldwide. Research shows that probiotics and prebiotics reduce the metabolic alterations caused by high-fat diets. Therefore, this work evaluated the effect of the incorporation of Lactobacillus acidophilus (probiotic) and inulin (prebiotic) in the diet through obesity markers (biochemical, anthropometric, and molecular markers) in an obese murine model. Four treatments were administered: (1) hypocaloric diet (HD), (2) HD + L. acidophilus, (3) HD + inulin, and (4) DH supplemented with L. acidophilus + inulin for 8 weeks. After treatment, glucose, triglycerides, total cholesterol, HDL-C, and LDL-C in plasma were determined. In addition, the total body weight and adipose tissue were taken to calculate the body mass index. Following RNA extraction from adipose tissue, the expression of PPAR gamma, PPAR alpha, and transforming growth factor beta 1 (TGF1beta) was evaluated by semiquantitative PCR. All treatments showed an improvement in biochemical markers compared to the values of the obese model (p < 0.05). Optimal values for blood glucose (133.2 +/- 14.3 mg/dL), triglycerides (71 +/- 4.6 mg/dL), total cholesterol (48.9 +/- 6 mg/dL), HDL-C (40.9 +/- 4.8 mg/dL), and LDL-C (8.4 +/- 1.7 mg/dL) were obtained in the mixed treatment. Regarding fat mass index (FMI), prebiotic treatment caused the greatest reduction. On the other hand, mixed treatment increased the gene expression of PPARalpha and TGF1beta in adipose tissue with DH with L. acidophilus and inulin treatment. This work demonstrates that the use of L. acidophilus and inulin as a complementary treatment is a viable alternative for prevention and action as a complementary treatment for obesity given the reduction in biochemical parameters and anthropometric indices; these reductions were greater than those found in the classic treatment of obesity due to the induction of the expression of genes related to lipid metabolism and anti-inflammatory cytokines, which contribute to reducing the high levels of glucose, triglycerides, and cholesterol caused by obesity. Copyright © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 9005-80-5 (Inulin). 0 (Cholesterol, LDL). 0 (Prebiotics). 97C5T2UQ7J (Cholesterol). 0 (Triglycerides). IY9XDZ35W2 (Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs12602-022-10012-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rangel-Torres&issn=1867-1306&title=Probiotics+%26+Antimicrobial+Proteins&atitle=The+Symbiosis+Between+Lactobacillus+acidophilus+and+Inulin%3A+Metabolic+Benefits+in+an+Obese+Murine+Model.&volume=16&issue=1&spage=26&epage=34&date=2024&doi=10.1007%2Fs12602-022-10012-y&pmid=36443558&sid=OVID:medline
+
+<128>
+Unique Identifier
+ 38073420
+Title
+ Alanine to glycine ratio is a novel predictive biomarker for type 2 diabetes mellitus.
+Source
+ Diabetes, Obesity & Metabolism. 26(3):980-988, 2024 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee KS; Lee YH; Lee SG
+Author NameID
+ Lee, Kwang Seob; ORCID: https://orcid.org/0000-0002-6286-108X
+ Lee, Yong-Ho; ORCID: https://orcid.org/0000-0002-6219-4942
+ Lee, Sang-Guk; ORCID: https://orcid.org/0000-0003-3862-3660
+Authors Full Name
+ Lee, Kwang Seob; Lee, Yong-Ho; Lee, Sang-Guk.
+Institution
+ Lee, Kwang Seob. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South Korea.
+ Lee, Yong-Ho. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
+ Lee, Yong-Ho. Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, South Korea.
+ Lee, Sang-Guk. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South Korea.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2
+ Risk Factors
+ Cohort Studies
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ Biomarkers
+Keyword Heading
+ alanine
+ biomarker
+ glycine
+ metabolite ratio
+ remission
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: We aimed to evaluate the metabolite ratios that could predict the clinical incidence or remission of type 2 diabetes mellitus (T2D).
+
+ METHODS: The Cox proportional hazards regression model was used to assess 1813 individuals without T2D to test the predictive value of metabolite ratios for T2D incidence and 451 newly diagnosed T2D for remission. The receiver operating characteristic curve analysis was performed to determine the best cut-off values for the metabolite ratios. Survival analyses were performed to compare the four subgroups defined by baseline metabolite ratios and clinical status of obesity.
+
+ RESULTS: The alanine/glycine was the most significant marker for T2D incidence (hazard ratio per SD: 1.24; p < .001). On the other hand, metabolite hydroxy sphingomyelin C22:2 was most specific for T2D remission (hazard ratio per SD: 1.32; p = .029). Survival analysis of T2D incidence among the subgroups defined by the combination of alanine/glycine and obesity showed the group with a high alanine/glycine and obesity had the highest risk of T2D incidence (p < .001). The alanine/glycine as a T2D risk marker was also validated in the independent external data.
+
+ CONCLUSIONS: The combination of obesity and the alanine/glycine ratio can be used to evaluate the diabetes risk. Copyright © 2023 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fdom.15395
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=1462-8902&title=Diabetes%2C+Obesity+%26+Metabolism&atitle=Alanine+to+glycine+ratio+is+a+novel+predictive+biomarker+for+type+2+diabetes+mellitus.&volume=26&issue=3&spage=980&epage=988&date=2024&doi=10.1111%2Fdom.15395&pmid=38073420&sid=OVID:medline
+
+<129>
+Unique Identifier
+ 38302990
+Title
+ mini-MED: study protocol for a randomized, multi-intervention, semi-controlled feeding trial of a Mediterranean-amplified vs. habitual Western dietary pattern for the evaluation of food-specific compounds and cardiometabolic health.
+Source
+ Trials [Electronic Resource]. 25(1):101, 2024 Feb 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hill EB; Tang M; Long JM; Kemp JF; Westcott JL; Hendricks AE; Reisdorph NA; Campbell WW; Krebs NF
+Author NameID
+ Hill, Emily B; ORCID: http://orcid.org/0000-0002-0308-5666
+Corporate Author
+ mini-MED Trial Team
+Authors Full Name
+ Hill, Emily B; Tang, Minghua; Long, Julie M; Kemp, Jennifer F; Westcott, Jamie L; Hendricks, Audrey E; Reisdorph, Nichole A; Campbell, Wayne W; Krebs, Nancy F.
+Institution
+ Hill, Emily B. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. emily.b.hill@cuanschutz.edu.
+ Tang, Minghua. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Long, Julie M. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Kemp, Jennifer F. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Westcott, Jamie L. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Hendricks, Audrey E. Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Hendricks, Audrey E. Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO, 80204, USA.
+ Reisdorph, Nichole A. Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
+ Campbell, Wayne W. Department of Nutrition Science, Purdue University, West Lafayette, IN, 47906, USA.
+ Krebs, Nancy F. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Nancy.Krebs@cuanschutz.edu.
+MeSH Subject Headings
+ Animals
+ Cattle
+ Humans
+ Dietary Patterns
+ Obesity/di [Diagnosis]
+ Obesity/pc [Prevention & Control]
+ *Diet, Mediterranean
+ Biomarkers
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Randomized Controlled Trials as Topic
+Keyword Heading
+ Biomarker
+ Diet assessment
+ Foodomics
+ Mediterranean diet
+ Metabolomics
+ Microbiome
+ Nutrimetabolomics
+ Randomized controlled trial
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Diet is among the most influential lifestyle factors impacting chronic disease risk. Nutrimetabolomics, the application of metabolomics to nutrition research, allows for the detection of food-specific compounds (FSCs) that can be used to connect dietary patterns, such as a Mediterranean-style (MED) diet, to health. This validation study is based upon analyses from a controlled feeding MED intervention, where our team identified FSCs from eight foods that can be detected in biospecimens after consumption and may therefore serve as food intake biomarkers.
+
+ METHODS: Individuals with overweight/obesity who do not habitually consume a MED dietary pattern will complete a 16-week randomized, multi-intervention, semi-controlled feeding study of isocaloric dietary interventions: (1) MED-amplified dietary pattern, containing 500 kcal/day from eight MED target foods: avocado, basil, cherry, chickpea, oat, red bell pepper, walnut, and a protein source (alternating between salmon or unprocessed, lean beef), and (2) habitual/Western dietary pattern, containing 500 kcal/day from six non-MED target foods: cheesecake, chocolate frozen yogurt, refined grain bread, sour cream, white potato, and unprocessed, lean beef. After a 2-week washout, participants complete four, 4-week intervention periods, with biospecimen sampling and outcome assessments at baseline and at intervention weeks 4, 8, 12, and 16. The primary outcome is change in the relative abundance of FSCs from the eight MED target foods in participant biospecimens from baseline to the end of each intervention period. Secondary outcomes include mean change in cardiometabolic health indicators, inflammatory markers, and adipokines. Exploratory outcomes include change in diversity and community composition of the gut microbiota.
+
+ DISCUSSION: Our stepwise strategy, beginning with identification of FSCs in whole diets and biospecimens, followed by relating these to health indicators will lead to improved methodology for assessment of dietary patterns and a better understanding of the relationship between food and health. This study will serve as a first step toward validating candidate food intake biomarkers and allow for assessment of relationships with cardiometabolic health. The identification of food intake biomarkers is critical to future research and has implications spanning health promotion and disease prevention for many chronic conditions.
+
+ TRIAL REGISTRATION: Registered at ClinicalTrials.gov: NCT05500976 ; Date of registration: August 15, 2022. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial Protocol. Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs13063-024-07939-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hill&issn=1745-6215&title=Trials+%5BElectronic+Resource%5D&atitle=mini-MED%3A+study+protocol+for+a+randomized%2C+multi-intervention%2C+semi-controlled+feeding+trial+of+a+Mediterranean-amplified+vs.+habitual+Western+dietary+pattern+for+the+evaluation+of+food-specific+compounds+and+cardiometabolic+health.&volume=25&issue=1&spage=101&epage=&date=2024&doi=10.1186%2Fs13063-024-07939-8&pmid=38302990&sid=OVID:medline
+
+<130>
+Unique Identifier
+ 38297286
+Title
+ Associations of triglyceride-glucose index with hyperuricemia among Royal Thai Army personnel.
+Source
+ BMC Endocrine Disorders. 24(1):17, 2024 Feb 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lertsakulbunlue S; Sangkool T; Bhuriveth V; Mungthin M; Rangsin R; Kantiwong A; Sakboonyarat B
+Authors Full Name
+ Lertsakulbunlue, Sethapong; Sangkool, Tanatip; Bhuriveth, Varathpavee; Mungthin, Mathirut; Rangsin, Ram; Kantiwong, Anupong; Sakboonyarat, Boonsub.
+Institution
+ Lertsakulbunlue, Sethapong. Department of Pharmacology, Phramongkutklao College of Medicine, 10400, Bangkok, Thailand.
+ Sangkool, Tanatip. Department of Military and Community Medicine, Phramongkutklao College of Medicine, 10400, Bangkok, Thailand.
+ Bhuriveth, Varathpavee. Medical cadet, Phramongkutklao College of Medicine, 10400, Bangkok, Thailand.
+ Mungthin, Mathirut. Department of Parasitology, Phramongkutklao College of Medicine, 10400, Bangkok, Thailand.
+ Rangsin, Ram. Department of Military and Community Medicine, Phramongkutklao College of Medicine, 10400, Bangkok, Thailand.
+ Kantiwong, Anupong. Department of Pharmacology, Phramongkutklao College of Medicine, 10400, Bangkok, Thailand.
+ Sakboonyarat, Boonsub. Department of Military and Community Medicine, Phramongkutklao College of Medicine, 10400, Bangkok, Thailand. boonsub1991@pcm.ac.th.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ Glucose
+ *Military Personnel
+ Hyperuricemia/di [Diagnosis]
+ Hyperuricemia/ep [Epidemiology]
+ *Hyperuricemia
+ Triglycerides
+ Uric Acid
+ Thailand/ep [Epidemiology]
+ Cross-Sectional Studies
+ *Insulin Resistance
+ Obesity
+ Risk Factors
+ Blood Glucose/an [Analysis]
+ Biomarkers
+Keyword Heading
+ Association
+ Effect modification
+ Hyperuricemia
+ Obesity
+ Relationship
+ Triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hyperuricemia has placed an immense burden on the global healthcare system. Studies have discovered a close correlation between serum uric acid (SUA) and insulin resistance (IR). The objective of this investigation is to examine the association between the triglyceride-glucose (TyG) index, a simple surrogate for IR, and the presence of hyperuricemia.
+
+ METHODS: Between 2017 and 2021, an epidemiologic study was conducted on Royal Thai Army (RTA) personnel aged 35-60 years, involving a total of 231,286 participants. In the study, hyperuricemia was defined as a SUA level of 7 mg/dL and 6 mg/dL among male and female participants, respectively. Using linear regression analysis and logistic regression analysis, the association between the TyG index and SUA was determined.
+
+ RESULTS: A positive relationship was demonstrated between the TyG index and the SUA. Overall, SUA increased by 0.32 per unit of TyG index growth (95% CI: 0.31-0.32). In comparison with the first quartile, employees in the fourth TyG quartile had a greater likelihood of having hyperuricemia [adjusted odds ratio (AOR): 2.45, 95% CI: 2.38-2.52]. Effect modification by obesity on the association between the TyG index and SUA was observed (P-interaction < 0.001). Among individuals with obesity, compared with the first TyG index quartile, the AOR for hyperuricemia was 2.15 (95% CI: 2.06-2.25) and 2.14 (95% CI: 1.81-2.53) for the fourth quartile of the TyG index for males and females, respectively. However, for nonobese personnel, in comparison to the top quartile of the TyG index, the AOR for hyperuricemia was 2.73 (95% CI:2.61-2.84) and 5.03 (95% CI: 4.03-6.29) for the fourth quartile of the TyG index for males and females, respectively. Personnel in the fourth TyG index quartile revealed that the prevalence of hyperuricemia reached 44.2%.
+
+ CONCLUSION: A robust positive association between the TyG index and SUA was illustrated among active-duty RTA personnel. Obesity was identified as a modifier influencing this relationship. Furthermore, individuals in the fourth quarter of the TyG index, regardless of their obesity status, could be considered appropriate candidates for screening SUA levels. Copyright © 2024. The Author(s).
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Triglycerides). 268B43MJ25 (Uric Acid). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1186%2fs12902-024-01542-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lertsakulbunlue&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Associations+of+triglyceride-glucose+index+with+hyperuricemia+among+Royal+Thai+Army+personnel.&volume=24&issue=1&spage=17&epage=&date=2024&doi=10.1186%2Fs12902-024-01542-3&pmid=38297286&sid=OVID:medline
+
+<131>
+Unique Identifier
+ 38225859
+Title
+ Serum Adipokines as Biomarkers for Surveillance of Metabolic Syndrome in Childhood Acute Lymphoblastic Leukemia Survivors in Low Middle-Income Countries.
+Source
+ Nutrition & Cancer. 76(3):262-270, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Das G; Setlur K; Jana M; Ramakrishnan L; Jain V; Meena JP; Gupta AK; Dwivedi SN; Seth R
+Authors Full Name
+ Das, Gargi; Setlur, Kritika; Jana, Manisha; Ramakrishnan, Lakshmy; Jain, Vandana; Meena, Jagdish Prasad; Gupta, Aditya Kumar; Dwivedi, Sada Nand; Seth, Rachna.
+Institution
+ Das, Gargi. Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences-New Delhi, India.
+ Setlur, Kritika. Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences-New Delhi, India.
+ Jana, Manisha. Department of Radiodiagnosis, All India Institute of Medical Sciences-New Delhi, India.
+ Ramakrishnan, Lakshmy. Department of Cardiac Biochemistry, All India Institute of Medical Sciences-New Delhi, India.
+ Jain, Vandana. Division of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences-New Delhi, India.
+ Meena, Jagdish Prasad. Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences-New Delhi, India.
+ Gupta, Aditya Kumar. Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences-New Delhi, India.
+ Dwivedi, Sada Nand. Department of Biostatistics, All India Institute of Medical Sciences-New Delhi, India.
+ Seth, Rachna. Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences-New Delhi, India.
+MeSH Subject Headings
+ Humans
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/et [Etiology]
+ *Metabolic Syndrome
+ Leptin
+ Adipokines
+ Adiponectin
+ Developing Countries
+ Precursor Cell Lymphoblastic Leukemia-Lymphoma/co [Complications]
+ *Precursor Cell Lymphoblastic Leukemia-Lymphoma
+ Obesity/co [Complications]
+ Survivors
+ Biomarkers
+Abstract
+ BACKGROUND: Serum adipokines (leptin and adiponectin) are dysregulated before the onset of metabolic syndrome and hence may be useful biomarkers for screening of cardiometabolic late effects in childhood Acute Lymphoblastic Leukemia (cALL) survivors.
+
+ METHODS: We compared serum adipokine levels between 40 cALL survivors (aged 10-18 years, >2 years from treatment completion) with similar controls. A multivariable logistic regression analysis was then done to assess the association of metabolic syndrome in cALL survivors with variables including adipokines and other metabolic parameters, demographic and treatment details, and Dual-energy X-ray absorptiometry scan-derived variables.
+
+ RESULTS: Compared to controls, cALL survivors had a higher prevalence of metabolic syndrome (8/40 vs. 2/40, P = .044) and central obesity (11/40 vs. 4/40, P = 0.042). Median Serum Leptin (7.39 vs. 4.23 ng/ml, P = 0.207) levels and derived Leptin-Adiponectin Ratio (1.44 vs. 0.80, P = 0.598), were higher but not statistically different in our survivors compared to controls; Adiponectin levels were similar (6.07 vs. 5.01 microg/ml, P = 0.283). In the cALL survivors, overweight/obesity (odds ratio [OR] 21.9, P = 0.020) or higher Leptin levels (OR 1.11, P = 0.047), were independently associated with metabolic syndrome.
+
+ CONCLUSIONS: Serum Leptin, independently predictive of metabolic syndrome in our cALL survivors, may be tested in larger studies to assess its utility in surveillance and initiation of early preventive measures.
+Registry Number/Name of Substance
+ 0 (Leptin). 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1080%2f01635581.2023.2301139
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Das&issn=0163-5581&title=Nutrition+%26+Cancer&atitle=Serum+Adipokines+as+Biomarkers+for+Surveillance+of+Metabolic+Syndrome+in+Childhood+Acute+Lymphoblastic+Leukemia+Survivors+in+Low+Middle-Income+Countries.&volume=76&issue=3&spage=262&epage=270&date=2024&doi=10.1080%2F01635581.2023.2301139&pmid=38225859&sid=OVID:medline
+
+<132>
+Unique Identifier
+ 38257150
+Title
+ Exploring the Link between Inflammatory Biomarkers and Adipometrics in Healthy Young Adults Aged 20-35 Years.
+Source
+ Nutrients. 16(2), 2024 Jan 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kosovski IB; Bacarea V; Ghiga D; Ciurea CN; Cucoranu DC; Hutanu A; Bacarea A
+Author NameID
+ Kosovski, Irina Bianca; ORCID: https://orcid.org/0000-0002-1172-8262
+ Ciurea, Cristina Nicoleta; ORCID: https://orcid.org/0000-0003-2262-7456
+ Hutanu, Adina; ORCID: https://orcid.org/0000-0001-9798-1594
+ Bacarea, Anca; ORCID: https://orcid.org/0000-0002-9473-0287
+Authors Full Name
+ Kosovski, Irina Bianca; Bacarea, Vladimir; Ghiga, Dana; Ciurea, Cristina Nicoleta; Cucoranu, Dragos Constantin; Hutanu, Adina; Bacarea, Anca.
+Institution
+ Kosovski, Irina Bianca. Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Kosovski, Irina Bianca. Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Bacarea, Vladimir. Department of Research Methodology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Ghiga, Dana. Department of Research Methodology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Ciurea, Cristina Nicoleta. Department of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Cucoranu, Dragos Constantin. Department of Radiology, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Hutanu, Adina. Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology Targu Mures, 540139 Targu Mures, Romania.
+ Bacarea, Anca. Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+MeSH Subject Headings
+ Humans
+ Young Adult
+ Adult
+ *C-Reactive Protein
+ *Overweight
+ Interleukin-6
+ Tumor Necrosis Factor-alpha
+ Biomarkers
+ Obesity
+ Interleukin-1beta
+Keyword Heading
+ anthropometric measurements
+ body composition
+ cytokines
+ healthy young adults
+ hsCRP
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and aging are associated with an inflammatory state, which represents the common background for a wide range of diseases. This study aims to explore the correlation between hsCRP, IL-1beta, IL-6, TNF-alpha, IFN-gamma, and white blood cell count (WBC) and adipometrics (arm, waist, and hip circumferences: AC, WC, HC; total body fat mass: TBFM, visceral fat level: VFL, body mass index: BMI; waist/hip ratio: WHR; waist/height ratio: WHtR) in young and healthy adults aged 20-35 years old. The subjects were divided by BMI into the overweight/obesity (OW/OB) group and normal weight (NW) group, and by hsCRP level into Group 1 (<1 mg/L), Group 2 (>=1-2.99 mg/L), and Group 3 (>=3 mg/L). The concentration of all inflammatory biomarkers was significantly higher in the OW/OB group compared to the NW group, with the exception of IL-1beta. Significant positive correlations were found between hsCRP, TNF-alpha, WBC, and all adipometrics; between IL-6 and WHR, WHtR, BMI, TBFM, and VFL; and between IFN-gamma and HC, BMI, and TBFM. IL-1beta correlates positively with WHR and VFL. In Groups 1-3, all the differences between the adipometrics showed significant differences. Subclinical inflammation persists in association with being overweight and obese in healthy young adults aged 20-35 years old.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha). 0 (Biomarkers). 0 (Interleukin-1beta).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu16020257
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kosovski&issn=2072-6643&title=Nutrients&atitle=Exploring+the+Link+between+Inflammatory+Biomarkers+and+Adipometrics+in+Healthy+Young+Adults+Aged+20-35+Years.&volume=16&issue=2&spage=&epage=&date=2024&doi=10.3390%2Fnu16020257&pmid=38257150&sid=OVID:medline
+
+<133>
+Unique Identifier
+ 38255954
+Title
+ Relationships between Circulating Biomarkers and Body Composition Parameters in Patients with Metabolic Syndrome: A Community-Based Study.
+Source
+ International Journal of Molecular Sciences. 25(2), 2024 Jan 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tarabeih N; Kalinkovich A; Ashkenazi S; Cherny SS; Shalata A; Livshits G
+Author NameID
+ Ashkenazi, Shai; ORCID: https://orcid.org/0000-0001-7244-0679
+ Cherny, Stacey S; ORCID: https://orcid.org/0000-0002-0269-3352
+ Livshits, Gregory; ORCID: https://orcid.org/0000-0003-3766-7493
+Authors Full Name
+ Tarabeih, Nader; Kalinkovich, Alexander; Ashkenazi, Shai; Cherny, Stacey S; Shalata, Adel; Livshits, Gregory.
+Institution
+ Tarabeih, Nader. Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
+ Kalinkovich, Alexander. Department of Anatomy and Anthropology, Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
+ Ashkenazi, Shai. Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
+ Cherny, Stacey S. Department of Anatomy and Anthropology, Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
+ Shalata, Adel. The Simon Winter Institute for Human Genetics, Bnai Zion Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 32000, Israel.
+ Livshits, Gregory. Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
+ Livshits, Gregory. Department of Anatomy and Anthropology, Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
+MeSH Subject Headings
+ Humans
+ *Metabolic Syndrome
+ Bayes Theorem
+ Growth Differentiation Factor 15
+ Body Composition
+ Biomarkers
+ Obesity
+ Adiponectin
+Keyword Heading
+ adipokines
+ body composition
+ inflammation
+ metabolic syndrome (MetS)
+ monocytes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Metabolic syndrome (MetS) is a complex disease involving multiple physiological, biochemical, and metabolic abnormalities. The search for reliable biomarkers may help to better elucidate its pathogenesis and develop new preventive and therapeutic strategies. In the present population-based study, we looked for biomarkers of MetS among obesity- and inflammation-related circulating factors and body composition parameters in 1079 individuals (with age range between 18 and 80) belonging to an ethnically homogeneous population. Plasma levels of soluble markers were measured by using ELISA. Body composition parameters were assessed using bioimpedance analysis (BIA). Statistical analysis, including mixed-effects regression, with MetS as a dependent variable, revealed that the most significant independent variables were mainly adipose tissue-related phenotypes, including fat mass/weight (FM/WT) [OR (95% CI)], 2.77 (2.01-3.81); leptin/adiponectin ratio (L/A ratio), 1.50 (1.23-1.83); growth and differentiation factor 15 (GDF-15) levels, 1.32 (1.08-1.62); inflammatory markers, specifically monocyte to high-density lipoprotein cholesterol ratio (MHR), 2.53 (2.00-3.15), and a few others. Additive Bayesian network modeling suggests that age, sex, MHR, and FM/WT are directly associated with MetS and probably affect its manifestation. Additionally, MetS may be causing the GDF-15 and L/A ratio. Our novel findings suggest the existence of complex, age-related, and possibly hierarchical relationships between MetS and factors associated with obesity.
+Registry Number/Name of Substance
+ 0 (Growth Differentiation Factor 15). 0 (Biomarkers). 0 (Adiponectin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fijms25020881
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tarabeih&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Relationships+between+Circulating+Biomarkers+and+Body+Composition+Parameters+in+Patients+with+Metabolic+Syndrome%3A+A+Community-Based+Study.&volume=25&issue=2&spage=881&epage=&date=2024&doi=10.3390%2Fijms25020881&pmid=38255954&sid=OVID:medline
+
+<134>
+Unique Identifier
+ 38122893
+Title
+ Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in metabolic dysfunction-associated steatotic liver disease.
+Source
+ Metabolism: Clinical & Experimental. 151:155762, 2024 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sarabhai T; Kahl S; Gancheva S; Mastrototaro L; Dewidar B; Pesta D; Ratter-Rieck JM; Bobrov P; Jeruschke K; Esposito I; Schlensak M; Roden M
+Authors Full Name
+ Sarabhai, Theresia; Kahl, Sabine; Gancheva, Sofiya; Mastrototaro, Lucia; Dewidar, Bedair; Pesta, Dominik; Ratter-Rieck, Jacqueline M; Bobrov, Pavel; Jeruschke, Kay; Esposito, Irene; Schlensak, Matthias; Roden, Michael.
+Institution
+ Sarabhai, Theresia. Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany; German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Kahl, Sabine. Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany; German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Gancheva, Sofiya. Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany; German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Mastrototaro, Lucia. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany; German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Dewidar, Bedair. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany; German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Pesta, Dominik. Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany; Centre for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Cologne, Germany.
+ Ratter-Rieck, Jacqueline M. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany; German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Bobrov, Pavel. German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany.
+ Jeruschke, Kay. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany; German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany.
+ Esposito, Irene. Institute of Pathology, University Hospital and Heinrich-Heine-University, Dusseldorf, Germany.
+ Schlensak, Matthias. Department of Obesity and Reflux Center, Neuwerk Hospital Monchengladbach, Germany.
+ Roden, Michael. Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University, Dusseldorf, Germany; German Center for Diabetes Research, Partner Dusseldorf, Neuherberg, Germany. Electronic address: michael.roden@ddz.de.
+MeSH Subject Headings
+ Humans
+ *Diabetes Mellitus, Type 2
+ Cross-Sectional Studies
+ Hydrogen Peroxide
+ *Fatty Liver
+ Mitophagy
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Ubiquitin-Protein Ligases/me [Metabolism]
+ Biomarkers
+ *Non-alcoholic Fatty Liver Disease
+Keyword Heading
+ Fatty liver
+ Insulin resistance
+ MASH
+ Mitochondrial function
+ Mitophagy
+ Obesity
+ Ultrastructure
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity and type 2 diabetes frequently have metabolic dysfunction-associated steatotic liver disease (MASLD) including steatohepatitis (MASH). In obesity, the liver may adapt its oxidative capacity, but the role of mitochondrial turnover in MASLD remains uncertain.
+
+ METHODS: This cross-sectional study compared individuals with class III obesity (n = 8/group) without (control, OBE CON; NAFLD activity score: 0.4 +/- 0.1) or with steatosis (OBE MASL, 2.3 +/- 0.4), or MASH (OBE MASH, 5.3 +/- 0.3, p < 0.05 vs. other groups). Hepatic mitochondrial ultrastructure was assessed by transmission electron microscopy, mitochondrial respiration by high-resolution respirometry, biomarkers of mitochondrial quality control and endoplasmic reticulum (ER) stress by Western Blot.
+
+ RESULTS: Mitochondrial oxidative capacity was 31 % higher in OBE MASL, but 25 % lower in OBE MASH (p < 0.05 vs. OBE CON). OBE MASH showed ~1.5fold lower mitochondrial number, but ~1.2-1.5fold higher diameter and area (p < 0.001 vs. other groups). Biomarkers of autophagy (p62), mitophagy (PINK1, PARKIN), fission (DRP-1, FIS1) and fusion (MFN1/2, OPA1) were reduced in OBE MASH (p < 0.05 vs. OBE CON). OBE MASL showed lower p62, p-PARKIN/PARKIN, and p-DRP-1 (p < 0.05 vs. OBE CON). OBE MASL and MASH showed higher ER stress markers (PERK, ATF4, p-eIF2alpha-S51/eIF2alpha; p < 0.05 vs. OBE CON). Mitochondrial diameter associated inversely with fusion/fission biomarkers and with oxidative capacity, but positively with H2O2.
+
+ CONCLUSION: Humans with hepatic steatosis already exhibit impaired mitochondrial turnover, despite upregulated oxidative capacity, and evidence for ER stress. In MASH, oxidative stress likely mediates progressive decline of mitochondrial turnover, ultrastructure and respiration indicating that mitochondrial quality control is key for energy metabolism and may have potential for targeting MASH. ClinGovTrial:NCT01477957. Copyright © 2023 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ BBX060AN9V (Hydrogen Peroxide). EC 2-3-2-27 (Ubiquitin-Protein Ligases). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.metabol.2023.155762
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sarabhai&issn=0026-0495&title=Metabolism%3A+Clinical+%26+Experimental&atitle=Loss+of+mitochondrial+adaptation+associates+with+deterioration+of+mitochondrial+turnover+and+structure+in+metabolic+dysfunction-associated+steatotic+liver+disease.&volume=151&issue=&spage=155762&epage=&date=2024&doi=10.1016%2Fj.metabol.2023.155762&pmid=38122893&sid=OVID:medline
+
+<135>
+Unique Identifier
+ 38072490
+Title
+ Effects of boron citrate supplementation on cardiometabolic factors, inflammatory biomarkers and anthropometric measures in obese patients: study protocol for a randomised, double-blind clinical trial.
+Source
+ BMJ Open. 13(12):e075941, 2023 12 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Naemi M; Naghshi S; Rostami S; Safaei E; Tutunchi H; Ostadrahimi A
+Author NameID
+ Naemi, Mohammad; ORCID: https://orcid.org/0000-0002-0456-5258
+ Naghshi, Sina; ORCID: https://orcid.org/0000-0001-6226-7403
+ Tutunchi, Helda; ORCID: https://orcid.org/0000-0002-4795-1757
+Authors Full Name
+ Naemi, Mohammad; Naghshi, Sina; Rostami, Somaye; Safaei, Ehsan; Tutunchi, Helda; Ostadrahimi, Alireza.
+Institution
+ Naemi, Mohammad. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Naghshi, Sina. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Rostami, Somaye. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Safaei, Ehsan. Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, USA.
+ Tutunchi, Helda. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran helda.nutrition@gmail.com ostadrahimi@tbzmed.ac.ir.
+ Ostadrahimi, Alireza. Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition& Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran helda.nutrition@gmail.com ostadrahimi@tbzmed.ac.ir.
+MeSH Subject Headings
+ Humans
+ Biomarkers
+ *Boron
+ *Cardiovascular Diseases
+ Citrates
+ Dietary Supplements
+ Double-Blind Method
+ Obesity/dt [Drug Therapy]
+ Randomized Controlled Trials as Topic
+ Treatment Outcome
+ Adolescent
+ Young Adult
+ Adult
+ Middle Aged
+Keyword Heading
+ NUTRITION & DIETETICS
+ Obesity
+ Randomized Controlled Trial
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity is a chronic disease with serious health consequences, but weight loss is difficult to maintain through lifestyle intervention alone. The efficacy and safety of boron citrate (BC), a novel therapeutic approach, in patients with obesity are not known. The current trial will take place to determine the effects of BC supplementation on cardiometabolic factors, inflammatory biomarkers, anthropometric measures and body composition in obese patients.
+
+ METHODS AND ANALYSIS: This double-blind, placebo-controlled, randomised clinical trial will involve 60 eligible obese participants aged 18-60 years. Participants will randomly be allocated to receive either BC capsules (containing 10 mg of boron) in the intervention group or placebo capsules (containing 10 mg of maltodextrin) in the placebo group for 12 weeks. Moreover, physical activity and dietary recommendations will be provided for both groups. To assess the dietary intakes of participants, a 3-day food record (2 days of the week and 1 day of the weekend) will be filled. Cardiometabolic factors, inflammatory biomarkers including tumour necrosis factor alpha, C reactive protein, interleukin-6 and interleukin-10 levels, anthropometric measures and body composition will be assessed at the baseline and end of the intervention. The findings of this study will provide evidence for the effectiveness of BC in the management of obesity.
+
+ ETHICS AND DISSEMINATION: There are so far no reported adverse effects associated with the use of boron. This trial was approved by the Ethics Committee of Tabriz University of Medical Sciences (approval number: IR.TBZMED.REC.1401.350). Positive as well as negative findings will be published in peer-reviewed journals.
+
+ TRIAL REGISTRATION NUMBER: IRCT20220806055624N1. Copyright © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). N9E3X5056Q (Boron). 0 (Citrates).
+Publication Type
+ Clinical Trial Protocol. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1136%2fbmjopen-2023-075941
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Naemi&issn=2044-6055&title=BMJ+Open&atitle=Effects+of+boron+citrate+supplementation+on+cardiometabolic+factors%2C+inflammatory+biomarkers+and+anthropometric+measures+in+obese+patients%3A+study+protocol+for+a+randomised%2C+double-blind+clinical+trial.&volume=13&issue=12&spage=e075941&epage=&date=2023&doi=10.1136%2Fbmjopen-2023-075941&pmid=38072490&sid=OVID:medline
+
+<136>
+Unique Identifier
+ 37338800
+Title
+ Selenium Biomarkers and Their Relationship to Cardiovascular Risk Parameters in Obese Women.
+Source
+ Biological Trace Element Research. 202(3):866-877, 2024 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cardoso BEP; da Cunha Soares T; da Silva Dias TM; Fontenelle LC; Morais JBS; Cruz KJC; de Paiva Sousa M; de Sousa TGV; de Sousa Melo SR; Dos Santos LR; Henriques GS; Oliveira FE; do Nascimento Marreiro D
+Author NameID
+ Cardoso, Bruna Emanuele Pereira; ORCID: http://orcid.org/0000-0002-3863-1276
+ da Cunha Soares, Tamires; ORCID: http://orcid.org/0000-0002-0466-5021
+ da Silva Dias, Thaline Milany; ORCID: http://orcid.org/0000-0003-1734-4312
+ Fontenelle, Larissa Cristina; ORCID: http://orcid.org/0000-0003-0156-6105
+ Morais, Jennifer Beatriz Silva; ORCID: http://orcid.org/0000-0002-9055-7851
+ Cruz, Kyria Jayanne Climaco; ORCID: http://orcid.org/0000-0002-4489-702X
+ de Paiva Sousa, Mickael; ORCID: http://orcid.org/0000-0002-8446-1351
+ de Sousa, Thayanne Gabryelle Visgueira; ORCID: http://orcid.org/0000-0002-9065-4504
+ de Sousa Melo, Stefany Rodrigues; ORCID: http://orcid.org/0000-0001-5308-3522
+ Dos Santos, Loanne Rocha; ORCID: http://orcid.org/0000-0002-5418-6715
+ Henriques, Gilberto Simeone; ORCID: http://orcid.org/0000-0002-9110-5427
+ Oliveira, Francisco Erasmo; ORCID: http://orcid.org/0000-0001-9941-3419
+ do Nascimento Marreiro, Dilina; ORCID: http://orcid.org/0000-0002-7550-1403
+Authors Full Name
+ Cardoso, Bruna Emanuele Pereira; da Cunha Soares, Tamires; da Silva Dias, Thaline Milany; Fontenelle, Larissa Cristina; Morais, Jennifer Beatriz Silva; Cruz, Kyria Jayanne Climaco; de Paiva Sousa, Mickael; de Sousa, Thayanne Gabryelle Visgueira; de Sousa Melo, Stefany Rodrigues; Dos Santos, Loanne Rocha; Henriques, Gilberto Simeone; Oliveira, Francisco Erasmo; do Nascimento Marreiro, Dilina.
+Institution
+ Cardoso, Bruna Emanuele Pereira. Department of Nutrition, Federal University of Piaui, Teresina, Brazil. brunaemanuelec@hotmail.com.
+ da Cunha Soares, Tamires. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ da Silva Dias, Thaline Milany. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Fontenelle, Larissa Cristina. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Morais, Jennifer Beatriz Silva. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Cruz, Kyria Jayanne Climaco. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ de Paiva Sousa, Mickael. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ de Sousa, Thayanne Gabryelle Visgueira. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ de Sousa Melo, Stefany Rodrigues. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Dos Santos, Loanne Rocha. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Henriques, Gilberto Simeone. School of Nursing, Federal University, Minas Gerais, Belo Horizonte, Brazil.
+ Oliveira, Francisco Erasmo. Med Imagem Clinical Laboratory, Teresina, Piaui, Brazil.
+ do Nascimento Marreiro, Dilina. Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina, Brazil.
+MeSH Subject Headings
+ Humans
+ Female
+ *Cardiovascular Diseases
+ *Selenium
+ Risk Factors
+ Cross-Sectional Studies
+ Body Mass Index
+ Obesity
+ Waist Circumference
+ Triglycerides
+ Heart Disease Risk Factors
+ Biomarkers
+ Blood Pressure
+Keyword Heading
+ Cardiovascular diseases
+ Obesity
+ Selenium
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ A cross-sectional study was carried out with 210 women divided into a case group (obese, n = 84) and a control group (eutrophic, n = 126). Body weight, height, waist circumference (WC), and hip and neck circumference were measured and the waist-hip ratio and conicity index were calculated. Selenium in plasma, erythrocytes and urine, erythrocyte GPx activity, lipid profile, Castelli I and II indices, and systolic and diastolic blood (DBP) pressure were evaluated. Mean dietary selenium intake (microg/kg/day) and plasma and erythrocyte concentrations were lower in the obese group compared to the healthy group (p < 0.001). while urinary selenium concentrations were higher (p < 0.001). There was a statistical difference between groups regarding cardiovascular risk parameters: waist circumference, neck circumference, waist-hip ratio, conicity index, triacylglycerols (TGC), and lipoproteins rich in triacylglycerols (VLDL-c) (p > 0.05). There was a negative correlation between plasma selenium concentrations and total cholesterol (TC), non-high-density lipoprotein (non-HDL), low-density lipoprotein (LDL-c), and systolic blood pressure (SBP). Urinary selenium correlated negatively with waist circumference and hip circumference and positively with neck circumference, TC, TGC, high-density lipoprotein (HDL-c), non-HDL, and VLDL-c. There was a negative correlation between dietary selenium and waist circumference, waist-hip ratio, neck circumference, conicity index, non-HDL cholesterol, LDL-c, and Castelli indices I and II, as well as a positive correlation with HDL-c and diastolic blood pressure. Women with obesity present changes in their nutritional status related to selenium, as well as increased cardiovascular risk parameters. Thus, the positive role of selenium in protecting the risk of cardiovascular disease is likely. Copyright © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ H6241UJ22B (Selenium). 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs12011-023-03726-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cardoso&issn=0163-4984&title=Biological+Trace+Element+Research&atitle=Selenium+Biomarkers+and+Their+Relationship+to+Cardiovascular+Risk+Parameters+in+Obese+Women.&volume=202&issue=3&spage=866&epage=877&date=2024&doi=10.1007%2Fs12011-023-03726-9&pmid=37338800&sid=OVID:medline
+
+<137>
+Unique Identifier
+ 38055934
+Title
+ Vaspin: A Novel Biomarker Linking Gluteofemoral Body Fat and Type 2 Diabetes Risk.
+Source
+ Diabetes Care. 47(2):259-266, 2024 Feb 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang HH; Chong M; Perrot N; Feiner J; Hess S; Yusuf S; Gerstein H; Pare G; Pigeyre M
+Author NameID
+ Gerstein, Hertzel; ORCID: https://orcid.org/0000-0001-8072-2836
+ Pare, Guillaume; ORCID: https://orcid.org/0000-0002-6795-4760
+ Pigeyre, Marie; ORCID: https://orcid.org/0000-0003-2984-8366
+Authors Full Name
+ Wang, Harry Hezhou; Chong, Michael; Perrot, Nicolas; Feiner, James; Hess, Sibylle; Yusuf, Salim; Gerstein, Hertzel; Pare, Guillaume; Pigeyre, Marie.
+Institution
+ Wang, Harry Hezhou. Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
+ Wang, Harry Hezhou. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.
+ Chong, Michael. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.
+ Chong, Michael. Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.
+ Chong, Michael. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
+ Chong, Michael. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Perrot, Nicolas. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.
+ Perrot, Nicolas. Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.
+ Perrot, Nicolas. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
+ Perrot, Nicolas. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Feiner, James. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.
+ Feiner, James. Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.
+ Feiner, James. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
+ Feiner, James. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Hess, Sibylle. Global Medical Diabetes, Sanofi, Frankfurt, Germany.
+ Yusuf, Salim. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.
+ Yusuf, Salim. Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Gerstein, Hertzel. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.
+ Gerstein, Hertzel. Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Pare, Guillaume. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.
+ Pare, Guillaume. Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.
+ Pare, Guillaume. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
+ Pare, Guillaume. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Pigeyre, Marie. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.
+ Pigeyre, Marie. Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Prospective Studies
+ Obesity
+ Biomarkers
+ Adiposity/ge [Genetics]
+ Adipose Tissue
+ Insulin Glargine
+ Mendelian Randomization Analysis
+ Body Mass Index
+Abstract
+ OBJECTIVE: To determine whether adiposity depots modulate vaspin levels and whether vaspin predicts type 2 diabetes (T2D) risk, through epidemiological and genetic analyses.
+
+ RESEARCH DESIGN AND METHODS: We assessed the relationship of plasma vaspin concentration with incident and prevalent T2D and adiposity-related variables in 1) the Prospective Urban and Rural Epidemiology (PURE) biomarker substudy (N = 10,052) and 2) the Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial (N = 7,840), using regression models. We then assessed whether vaspin is causally associated with T2D and whether genetic variants associated with MRI-measured adiposity depots modulate vaspin levels, using two-sample Mendelian randomization (MR).
+
+ RESULTS: A 1-SD increase in circulating vaspin levels was associated with a 16% increase in incident T2D in the PURE cohort (hazard ratio 1.16; 95% CI 1.09-1.23; P = 4.26 x 10-7) and prevalent T2D in the ORIGIN cohort (odds ratio [OR] 1.16; 95% CI 1.07-1.25; P = 2.17 x 10-4). A 1-unit increase in BMI and triglyceride levels was associated with a 0.08-SD (95% CI 0.06-0.10; P = 2.04 x 10-15) and 0.06-SD (95% CI 0.04-0.08; P = 4.08 x 10-13) increase, respectively, in vaspin in the PURE group. Consistent associations were observed in the ORIGIN cohort. MR results reinforced the association between vaspin and BMI-adjusted T2D risk (OR 1.01 per 1-SD increase in vaspin level; 95% CI 1.00-1.02; P = 2.86 x 10-2) and showed that vaspin was increased by 0.10 SD per 1-SD decrease in genetically determined gluteofemoral adiposity (95% CI 0.02-0.18; P = 2.01 x 10-2). No relationships were found between subcutaneous or visceral adiposity and vaspin.
+
+ CONCLUSIONS: These findings support that higher vaspin levels are related to increased T2D risk and reduced gluteofemoral adiposity, positioning vaspin as a promising clinical predictor for T2D. Copyright © 2024 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 2ZM8CX04RZ (Insulin Glargine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.2337%2fdc23-1488
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0149-5992&title=Diabetes+Care&atitle=Vaspin%3A+A+Novel+Biomarker+Linking+Gluteofemoral+Body+Fat+and+Type+2+Diabetes+Risk.&volume=47&issue=2&spage=259&epage=266&date=2024&doi=10.2337%2Fdc23-1488&pmid=38055934&sid=OVID:medline
+
+<138>
+Unique Identifier
+ 37669834
+Title
+ Haptoglobin is an independent marker for disease severity and risk for metabolic complications in hidradenitis suppurativa: A prospective study.
+Source
+ Journal of the European Academy of Dermatology & Venereology. 38(1):205-213, 2024 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abu Rached N; Gambichler T; Ocker L; Skrygan M; Seifert C; Scheel CH; Stockfleth E; Bechara FG
+Author NameID
+ Abu Rached, N; ORCID: https://orcid.org/0000-0001-6853-0743
+Authors Full Name
+ Abu Rached, N; Gambichler, T; Ocker, L; Skrygan, M; Seifert, C; Scheel, C H; Stockfleth, E; Bechara, F G.
+Institution
+ Abu Rached, N. Department of Dermatology, Venereology and Allergology, International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Ruhr-University Bochum, Bochum, Germany.
+ Abu Rached, N. Department of Dermatology, Venereology and Allergology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
+ Gambichler, T. Department of Dermatology, Venereology and Allergology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
+ Gambichler, T. Department of Dermatology and Phlebology, Christian Hospital Unna, Unna, Germany.
+ Ocker, L. Department of Dermatology, Venereology and Allergology, International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Ruhr-University Bochum, Bochum, Germany.
+ Ocker, L. Department of Dermatology, Venereology and Allergology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
+ Skrygan, M. Department of Dermatology, Venereology and Allergology, International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Ruhr-University Bochum, Bochum, Germany.
+ Skrygan, M. Department of Dermatology, Venereology and Allergology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
+ Seifert, C. Department of Dermatology, Venereology and Allergology, International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Ruhr-University Bochum, Bochum, Germany.
+ Seifert, C. Department of Dermatology, Venereology and Allergology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
+ Scheel, C H. Department of Dermatology, Venereology and Allergology, International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Ruhr-University Bochum, Bochum, Germany.
+ Scheel, C H. Department of Dermatology, Venereology and Allergology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
+ Stockfleth, E. Department of Dermatology, Venereology and Allergology, International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Ruhr-University Bochum, Bochum, Germany.
+ Stockfleth, E. Department of Dermatology, Venereology and Allergology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
+ Bechara, F G. Department of Dermatology, Venereology and Allergology, International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Ruhr-University Bochum, Bochum, Germany.
+ Bechara, F G. Department of Dermatology, Venereology and Allergology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
+MeSH Subject Headings
+ Humans
+ Biomarkers
+ Haptoglobins
+ Hidradenitis Suppurativa/di [Diagnosis]
+ *Hidradenitis Suppurativa
+ Inflammation/co [Complications]
+ Obesity/co [Complications]
+ Patient Acuity
+ Prospective Studies
+ Severity of Illness Index
+ Serine/df [Deficiency]
+ *Serine
+ Disease Progression
+Abstract
+ BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that is highly correlated with obesity. Haptoglobin serum levels have recently been recognized as an important biomarker linking obesity with chronic inflammation.
+
+ OBJECTIVE: To compare haptoglobin with previously proposed serum biomarkers for the determination of disease severity in HS patients. For this purpose, disease severity of HS patients was determined by a panel of clinical scores as well as several risk factors, such as weight and smoking habits.
+
+ METHODS: A prospective, diagnostic accuracy study was performed at the International Centre for Hidradenitis suppurativa/Acne inversa Bochum (ICH). The study included a total of 263 patients, including 131 who had a confirmed diagnosis of HS in Hurley I (n = 16), II (n = 56) and III (n = 59) HS, and 132 healthy controls. The main outcome was to identify serological inflammatory markers for HS disease severity [severe (III) vs. moderate/mild (II/I)] as assessed by Hurley classification.
+
+ RESULTS: The serum levels of acute phase proteins haptoglobin and CRP, as well as the number of neutrophils in peripheral blood, number of monocytes, the systemic immune-inflammation index and the pan-immune-inflammatory value correlated with disease severity according to established clinical scores (mHSS, SAHS, Hurley, DLQI). HS patients had significantly higher haptologlobin levels compared to healthy controls. Logistic regression analysis revealed haptoglobin as the only independent marker predicting severe HS.
+
+ CONCLUSION: In this prospective study, we discovered that the serum levels of the acute phase protein haptoglobin levels serve as an independent marker of disease severity in HS. While this presents the first study in the context of HS. Thus, the present data not only yield a highly promising serum marker to be further validated. Copyright © 2023 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Haptoglobins). 452VLY9402 (Serine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1111%2fjdv.19495
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abu+Rached&issn=0926-9959&title=Journal+of+the+European+Academy+of+Dermatology+%26+Venereology&atitle=Haptoglobin+is+an+independent+marker+for+disease+severity+and+risk+for+metabolic+complications+in+hidradenitis+suppurativa%3A+A+prospective+study.&volume=38&issue=1&spage=205&epage=213&date=2024&doi=10.1111%2Fjdv.19495&pmid=37669834&sid=OVID:medline
+
+<139>
+Unique Identifier
+ 38232103
+Title
+ Metabolomic signature between diabetic and non-diabetic obese patients: A protocol for systematic review.
+Source
+ PLoS ONE [Electronic Resource]. 19(1):e0296749, 2024.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tai Y; Yang X; Gang X; Cong Z; Wang S; Li P; Liu M
+Author NameID
+ Liu, Mingjun; ORCID: https://orcid.org/0000-0002-9058-1720
+Authors Full Name
+ Tai, Yuxing; Yang, Xiaoqian; Gang, Xiaochao; Cong, Zhengri; Wang, Sixian; Li, Peizhe; Liu, Mingjun.
+Institution
+ Tai, Yuxing. Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
+ Yang, Xiaoqian. Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, China.
+ Gang, Xiaochao. Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
+ Cong, Zhengri. Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
+ Wang, Sixian. Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
+ Li, Peizhe. Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
+ Liu, Mingjun. Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
+ Liu, Mingjun. Acupuncture and Massage Center of the Third Afliated Clinical Hospital, Changchun University of Chinese Medicine, Changchun, Jilin, China.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Systematic Reviews as Topic
+ Obesity/co [Complications]
+ *Hyperglycemia
+ *Insulin Resistance
+ Research Design
+ Biomarkers
+ Review Literature as Topic
+Abstract
+ BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic and progressive condition defined by hyperglycemia caused by abnormalities in insulin production, insulin receptor sensitivity, or both. Several studies have revealed that higher body mass index (BMI) is associated with increasing risk of developing diabetes. In this study, we perform a protocol for systematic review to explore metabolite biomarkers that could be used to identify T2DM in obese subjects.
+
+ METHODS: The protocol of this review was registered in PROSPERO (CRD42023405518). Three databases, EMBASE, PubMed, and Web of Science were selected to collect potential literature from their inceptions to July December 2023. Data for collection will include title, authors, study subjects, publication date, sample size, detection and analytical platforms, participant characteristics, biological samples, confounding factors, methods of statistical analysis, the frequency and directions of changes in potential metabolic biomarkers, and major findings. Pathway analysis of differential metabolites will be performed with MetaboAnalyst 5.0 based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) and the Human Metabolome Database.
+
+ RESULTS: The results of this systematic review will be published in a peer-reviewed journal.
+
+ CONCLUSION: This systematic review will summarize the potential biomarkers and metabolic pathways to provide a new reference for the prevention and treatment of T2DM in obese subjects. Copyright: © 2024 Tai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1371%2fjournal.pone.0296749
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tai&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Metabolomic+signature+between+diabetic+and+non-diabetic+obese+patients%3A+A+protocol+for+systematic+review.&volume=19&issue=1&spage=e0296749&epage=&date=2024&doi=10.1371%2Fjournal.pone.0296749&pmid=38232103&sid=OVID:medline
+
+<140>
+Unique Identifier
+ 38165489
+Title
+ A new immunosensing platform based on conjugated Poly(ThidEp-co-EDOT) copolymer for resistin detection, a new obesity biomarker.
+Source
+ Mikrochimica Acta. 191(1):69, 2024 01 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aydin EB; Aydin M; Sezginturk MK
+Author NameID
+ Aydin, Elif Burcu; ORCID: https://orcid.org/0000-0002-1982-4128
+Authors Full Name
+ Aydin, Elif Burcu; Aydin, Muhammet; Sezginturk, Mustafa Kemal.
+Institution
+ Aydin, Elif Burcu. Scientific and Technological Research Center, Tekirdag Namik Kemal University, Tekirdag, Turkey. ebbahadir@nku.edu.tr.
+ Aydin, Muhammet. Scientific and Technological Research Center, Tekirdag Namik Kemal University, Tekirdag, Turkey.
+ Sezginturk, Mustafa Kemal. Faculty of Engineering, Bioengineering Department, Canakkale Onsekiz Mart University, Canakkale, Turkey.
+MeSH Subject Headings
+ Humans
+ *Resistin
+ *Biosensing Techniques
+ Immunoassay
+ Reproducibility of Results
+ Biomarkers
+ Obesity/di [Diagnosis]
+ Poly A
+ Polymers
+Keyword Heading
+ Conjugated thiophene polymer
+ Electrochemical immunosensor
+ Electrochemical impedance spectroscopy
+ Modified electrode
+ Obesity
+ Resistin
+ Single-frequency impedance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The design of a novel electrochemical impedimetric biosensor for label-free analysis of resistin, a biomarker for obesity, is reported. For the fabrication of the immunosensor, a novel approach composed of electrochemical copolymerization of double epoxy groups-substituted thiophene (ThidEp) and 3,4-Ethylenedioxythiophene (EDOT) monomers was utilized. Anti-resistin antibodies were covalently attached to the copolymer-coated electrode. The capture of resistin antigens by anti-resistin antibodies caused significant variations in charge transfer resistance (Rct) because of the immunoreactions between these proteins. Under optimum experimental variables, the changes in impedance signals were employed for the determination of resistin antigen concentration, and the prepared immunosensor based on conjugated copolymer illustrated a wide linear range between 0.0125 and 22.5 pg/mL, a low detection limit (LOD) of 3.71 fg/mL, and a good sensitivity of 1.22 kOMEGA pg-1mL cm2. The excellent analytical performance of the resistin immunosensor in terms of selectivity, sensitivity, repeatability, reproducibility, storage stability, and low detection limit might be attributed to the conductive copolymer film layer generation on the disposable indium tin oxide (ITO) platform. The capability of this system for the determination of resistin in human serum and saliva samples was also tested. The immunosensor results were in accordance with the enzyme-linked immunosorbent assay (ELISA) results. The matrix effects of human serum and saliva were also investigated, and the proposed immunosensor displayed good recovery ranging from 95.91 to 106.25%. The engineered immunosensor could open new avenues for obesity monitoring. Copyright © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Resistin). 0 (Biomarkers). 24937-83-5 (Poly A). 0 (Polymers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1007%2fs00604-023-06145-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aydin&issn=0026-3672&title=Mikrochimica+Acta&atitle=A+new+immunosensing+platform+based+on+conjugated+Poly%28ThidEp-co-EDOT%29+copolymer+for+resistin+detection%2C+a+new+obesity+biomarker.&volume=191&issue=1&spage=69&epage=&date=2024&doi=10.1007%2Fs00604-023-06145-8&pmid=38165489&sid=OVID:medline
+
+<141>
+Unique Identifier
+ 37980222
+Title
+ Obesity and Impaired Lung Function in Young Adults: The Value of MRI-Derived Biomarkers of Muscle Health.
+Source
+ Academic Radiology. 31(1):19-21, 2024 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Almansour H
+Authors Full Name
+ Almansour, Haidara.
+Institution
+ Almansour, Haidara. Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tuebingen University Hospital, Hoppe-Seyler-str 3, Tuebingen 72076, Germany. Electronic address: haidar.almansour@gmail.com.
+MeSH Subject Headings
+ Humans
+ Young Adult
+ *Obesity
+ *Muscles
+ Biomarkers
+ Lung
+ Magnetic Resonance Imaging
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.acra.2023.10.056
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Almansour&issn=1076-6332&title=Academic+Radiology&atitle=Obesity+and+Impaired+Lung+Function+in+Young+Adults%3A+The+Value+of+MRI-Derived+Biomarkers+of+Muscle+Health.&volume=31&issue=1&spage=19&epage=21&date=2024&doi=10.1016%2Fj.acra.2023.10.056&pmid=37980222&sid=OVID:medline
+
+<142>
+Unique Identifier
+ 37243891
+Title
+ Levels of Alzheimer's disease blood biomarkers are altered after food intake-A pilot intervention study in healthy adults.
+Source
+ Alzheimer's & Dementia. 19(12):5531-5540, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huber H; Ashton NJ; Schieren A; Montoliu-Gaya L; Molfetta GD; Brum WS; Lantero-Rodriguez J; Grotschel L; Stoffel-Wagner B; Coenen M; Weinhold L; Schmid M; Blennow K; Stehle P; Zetterberg H; Simon MC
+Authors Full Name
+ Huber, Hanna; Ashton, Nicholas J; Schieren, Alina; Montoliu-Gaya, Laia; Molfetta, Guglielmo Di; Brum, Wagner S; Lantero-Rodriguez, Juan; Grotschel, Lana; Stoffel-Wagner, Birgit; Coenen, Martin; Weinhold, Leonie; Schmid, Matthias; Blennow, Kaj; Stehle, Peter; Zetterberg, Henrik; Simon, Marie-Christine.
+Institution
+ Huber, Hanna. Nutritional Physiology, Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany.
+ Huber, Hanna. Nutrition and Microbiota, Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany.
+ Huber, Hanna. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Ashton, Nicholas J. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Ashton, Nicholas J. Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
+ Ashton, Nicholas J. Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
+ Schieren, Alina. Nutrition and Microbiota, Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany.
+ Montoliu-Gaya, Laia. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Molfetta, Guglielmo Di. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Brum, Wagner S. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Brum, Wagner S. Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
+ Lantero-Rodriguez, Juan. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Grotschel, Lana. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Stoffel-Wagner, Birgit. Central Laboratory, Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
+ Coenen, Martin. Clinical Study Core Unit, Study Center Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
+ Weinhold, Leonie. Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
+ Schmid, Matthias. Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
+ Blennow, Kaj. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Blennow, Kaj. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal Hospital, Molndal, Sweden.
+ Stehle, Peter. Nutritional Physiology, Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany.
+ Zetterberg, Henrik. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal Hospital, Molndal, Sweden.
+ Zetterberg, Henrik. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal Hospital, Molndal, Sweden.
+ Zetterberg, Henrik. Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
+ Zetterberg, Henrik. UK Dementia Research Institute at UCL, London, UK.
+ Zetterberg, Henrik. Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
+ Zetterberg, Henrik. Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
+ Simon, Marie-Christine. Nutrition and Microbiota, Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany.
+MeSH Subject Headings
+ Adult
+ Humans
+ Alzheimer Disease/di [Diagnosis]
+ *Alzheimer Disease
+ Pilot Projects
+ Amyloid beta-Peptides
+ tau Proteins
+ Biomarkers
+ Obesity
+ Eating
+Keyword Heading
+ amyloid beta
+ biomarkers
+ blood
+ diurnal variations
+ fasting
+ food intake
+ glial fibrillary acidic protein
+ neurofilament light
+ obesity
+ phosphorylated tau
+ plasma
+ postprandial
+ pre-analytical standardization
+ total tau
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Blood biomarkers accurately identify Alzheimer's disease (AD) pathophysiology and axonal injury. We investigated the influence of food intake on AD-related biomarkers in cognitively healthy, obese adults at high metabolic risk.
+
+ METHODS: One-hundred eleven participants underwent repeated blood sampling during 3 h after a standardized meal (postprandial group, PG). For comparison, blood was sampled from a fasting subgroup over 3 h (fasting group, FG). Plasma neurofilament light (NfL), glial fibrillary acidic protein (GFAP), amyloid-beta (Abeta) 42/40, phosphorylated tau (p-tau) 181 and 231, and total-tau were measured via single molecule array assays.
+
+ RESULTS: Significant differences were found for NfL, GFAP, Abeta42/40, p-tau181, and p-tau231 between FG and PG. The greatest change to baseline occurred for GFAP and p-tau181 (120 min postprandially, p < 0.0001).
+
+ CONCLUSION: Our data suggest that AD-related biomarkers are altered by food intake. Further studies are needed to verify whether blood biomarker sampling should be performed in the fasting state.
+
+ HIGHLIGHTS: Acute food intake alters plasma biomarkers of Alzheimer's disease in obese, otherwise healthy adults. We also found dynamic fluctuations in plasma biomarkers concentration in the fasting state suggesting physiological diurnal variations. Further investigations are highly needed to verify if biomarker measurements should be performed in the fasting state and at a standardized time of day to improve the diagnostic accuracy. Copyright © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Peptides). 0 (tau Proteins). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1002%2falz.13163
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huber&issn=1552-5260&title=Alzheimer%27s+%26+Dementia&atitle=Levels+of+Alzheimer%27s+disease+blood+biomarkers+are+altered+after+food+intake-A+pilot+intervention+study+in+healthy+adults.&volume=19&issue=12&spage=5531&epage=5540&date=2023&doi=10.1002%2Falz.13163&pmid=37243891&sid=OVID:medline
+
+<143>
+Unique Identifier
+ 37949711
+Title
+ Association between the triglyceride glucose index and cardiovascular mortality in obese population.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 34(1):107-111, 2024 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Du L; Xu X; Wu Y; Yao H
+Authors Full Name
+ Du, Lin; Xu, Xiaotian; Wu, Yong; Yao, Hongsu.
+Institution
+ Du, Lin. Department of Cardiology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
+ Xu, Xiaotian. Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
+ Wu, Yong. Department of Cardiology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
+ Yao, Hongsu. Department of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, China. Electronic address: shy0928@163.com.
+MeSH Subject Headings
+ Humans
+ Nutrition Surveys
+ *Glucose
+ Obesity/di [Diagnosis]
+ Triglycerides
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases
+ Blood Glucose
+ Biomarkers
+ Risk Factors
+Keyword Heading
+ All-cause mortality
+ Cardiovascular mortality
+ Insulin resistance
+ Obesity
+ Triglyceride glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: The triglyceride and glucose (TyG) index, as a surrogate marker of insulin resistance, was related to increased mortality. Our study aimed to investigate the specific relationship between the TyG index and all-cause mortality among obese population.
+
+ METHODS AND RESULTS: 6731 participants with obesity were enrolled from the National Health and Nutrition Examination Survey (NHANES). The TyG index was calculated as log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. The baseline levels of TyG associated with the risk of all-cause and cardiovascular mortality were evaluated by Cox proportional hazards models. After a follow-up of 16.7 years, 693 all-cause death and 133 cardiovascular deaths occurred. Dose-response curve showed that the association of the risk of all-cause mortality was non-linear (p = 0.019) and the corresponding TyG index ranged 8.78 to 9.64 for the lowest risk. Compared with the reference quartile of 8.79-9.22, the multivariate-adjusted hazards ratios were 1.32 ((95% confidence interval 1.03-1.70; p = 0.030) in the lowest quartile for all-cause mortality, and 0.55 (0.32-0.93; p = 0.025) in the second quartile for cardiovascular mortality.
+
+ CONCLUSIONS: TyG index was associated with the risk of all-cause mortality in obese participants and the level associated with the lowest risk was 8.78-9.64. Copyright © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.numecd.2023.08.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Du&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Association+between+the+triglyceride+glucose+index+and+cardiovascular+mortality+in+obese+population.&volume=34&issue=1&spage=107&epage=111&date=2024&doi=10.1016%2Fj.numecd.2023.08.007&pmid=37949711&sid=OVID:medline
+
+<144>
+Unique Identifier
+ 38140297
+Title
+ Effects of Fish Oil Supplementation on Reducing the Effects of Paternal Obesity and Preventing Fatty Liver in Offspring.
+Source
+ Nutrients. 15(24), 2023 Dec 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shrestha A; Dellett SK; Yang J; Sharma U; Ramalingam L
+Author NameID
+ Ramalingam, Latha; ORCID: https://orcid.org/0000-0002-4856-7327
+Authors Full Name
+ Shrestha, Akriti; Dellett, Sarah Katherine; Yang, Junhui; Sharma, Upasna; Ramalingam, Latha.
+Institution
+ Shrestha, Akriti. Department of Nutrition and Food Studies, Syracuse University, Syracuse, NY 13244, USA.
+ Dellett, Sarah Katherine. Department of Nutrition and Food Studies, Syracuse University, Syracuse, NY 13244, USA.
+ Yang, Junhui. Department of Nutrition and Food Studies, Syracuse University, Syracuse, NY 13244, USA.
+ Sharma, Upasna. Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
+ Ramalingam, Latha. Department of Nutrition and Food Studies, Syracuse University, Syracuse, NY 13244, USA.
+MeSH Subject Headings
+ Male
+ Female
+ Mice
+ Animals
+ Humans
+ Fish Oils/pd [Pharmacology]
+ Fish Oils/me [Metabolism]
+ *Fish Oils
+ Obesity/pc [Prevention & Control]
+ Obesity/me [Metabolism]
+ Dietary Supplements
+ Diet, High-Fat/ae [Adverse Effects]
+ Liver/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/pc [Prevention & Control]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Fathers
+ Biomarkers/me [Metabolism]
+ Fatty Acids/me [Metabolism]
+ Mice, Inbred C57BL
+Keyword Heading
+ epigenetic
+ intergenerational
+ liver
+ omega-3 fatty acids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) is a serious public health concern, which calls for appropriate diet/nutrition intervention. Fish oil (FO) has several benefits in reducing obesity, but its intergenerational role in reducing the effects of paternal obesity has not been established. Hence, we hypothesized that FO supplementation to an obese father during the pre-conceptional period could improve the metabolic health of the offspring, specifically in the liver. Three groups of male mice were fed with a low-fat (LF), high-fat (HF), or high-fat diet supplemented with FO (HF-FO) for 10 weeks and were then allowed to mate with female mice fed a chow diet. Offspring were sacrificed at 16 weeks. The liver tissue was harvested for genomic and histological analyses. The offspring of HF and HF-FO fathers were heavier compared to that of the LF mice during 9-16 weeks. The glucose tolerance of the offspring of HF-FO fathers were significantly improved as compared to the offspring of HF fathers. Paternal FO supplementation significantly lowered inflammation and fatty acid synthesis biomarkers and increased fatty acid oxidation biomarkers in the offspring liver. In summary, FO supplementation in fathers shows the potential to reduce metabolic and cardiovascular diseases through genetic means in offspring.
+Registry Number/Name of Substance
+ 0 (Fish Oils). 0 (Biomarkers). 0 (Fatty Acids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3390%2fnu15245038
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shrestha&issn=2072-6643&title=Nutrients&atitle=Effects+of+Fish+Oil+Supplementation+on+Reducing+the+Effects+of+Paternal+Obesity+and+Preventing+Fatty+Liver+in+Offspring.&volume=15&issue=24&spage=&epage=&date=2023&doi=10.3390%2Fnu15245038&pmid=38140297&sid=OVID:medline
+
+<145>
+Unique Identifier
+ 37589958
+Title
+ Effects of Bariatric Surgery on Blood and Vascular Large Extracellular Vesicles According to Type 2 Diabetes Status.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 109(1):e107-e118, 2023 Dec 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pane A; Viaplana J; Giro O; Llopis J; Ibarzabal A; de Hollanda A; Vidal J; Ortega E; Jimenez A; Chiva-Blanch G
+Author NameID
+ Pane, Adriana; ORCID: https://orcid.org/0000-0002-7810-1827
+ Viaplana, Judith; ORCID: https://orcid.org/0000-0002-8560-0309
+ Giro, Oriol; ORCID: https://orcid.org/0000-0002-0941-6542
+ Ibarzabal, Ainitze; ORCID: https://orcid.org/0000-0002-1220-6474
+ de Hollanda, Ana; ORCID: https://orcid.org/0000-0001-9114-8614
+ Vidal, Josep; ORCID: https://orcid.org/0000-0002-4564-4518
+ Ortega, Emilio; ORCID: https://orcid.org/0000-0002-2217-8905
+ Jimenez, Amanda; ORCID: https://orcid.org/0000-0003-4967-1174
+ Chiva-Blanch, Gemma; ORCID: https://orcid.org/0000-0001-6093-0160
+Authors Full Name
+ Pane, Adriana; Viaplana, Judith; Giro, Oriol; Llopis, Jaume; Ibarzabal, Ainitze; de Hollanda, Ana; Vidal, Josep; Ortega, Emilio; Jimenez, Amanda; Chiva-Blanch, Gemma.
+Institution
+ Pane, Adriana. Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
+ Pane, Adriana. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Pane, Adriana. Fundacio Clinic per a la Recerca Biomedica (FCRB), Barcelona, Spain.
+ Viaplana, Judith. Fundacio Clinic per a la Recerca Biomedica (FCRB), Barcelona, Spain.
+ Giro, Oriol. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Giro, Oriol. Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
+ Llopis, Jaume. Department of Genetics, Microbiology and Statistics, Universitat de Barcelona, Barcelona, Spain.
+ Ibarzabal, Ainitze. Department of Gastrointestinal Surgery, Hospital Clinic, Barcelona, Spain.
+ de Hollanda, Ana. Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
+ de Hollanda, Ana. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ de Hollanda, Ana. Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
+ Vidal, Josep. Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
+ Vidal, Josep. Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
+ Vidal, Josep. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Ortega, Emilio. Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
+ Ortega, Emilio. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Ortega, Emilio. Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
+ Jimenez, Amanda. Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
+ Jimenez, Amanda. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Jimenez, Amanda. Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
+ Chiva-Blanch, Gemma. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Chiva-Blanch, Gemma. Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
+ Chiva-Blanch, Gemma. Health Science Faculty, Universitat Oberta de Catalunya (UOC), Barcelona, Spain.
+MeSH Subject Headings
+ Female
+ Humans
+ Adult
+ Middle Aged
+ Male
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/su [Surgery]
+ *Diabetes Mellitus, Type 2
+ Prospective Studies
+ Longitudinal Studies
+ Obesity/su [Surgery]
+ Bariatric Surgery/mt [Methods]
+ *Bariatric Surgery
+ Biomarkers
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+Keyword Heading
+ cardiovascular risk
+ exosomes
+ microparticles
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Large extracellular vesicles (lEVs) enriched for endothelial and blood cell markers are increased in metabolic conditions such as obesity or type 2 diabetes (T2D), actively contribute to the atherosclerotic process, and have been identified as diagnostic and prognostic biomarkers for cardiovascular disease (CVD). Although bariatric surgery (BS) in individuals with obesity is related to decreased cardiovascular (CV) risk and increased life expectancy, after BS these subjects are still at higher CV risk than the general population.
+
+ OBJECTIVE: We aimed to compare the lEV profiles between individuals with obesity, with or without T2D, before and 1 year after BS, and normal-weight controls.
+
+ METHODS: Prospective longitudinal study with individuals eligible for BS, with or without T2D (T2D and OB groups, respectively) and healthy controls (HC group) matched by age and sex. The concentration and phenotype of lEVs were assessed by flow cytometry.
+
+ RESULTS: The study cohort included 108 individuals (age 48.0 +/- 10.5 years; 84.3% females). Before BS, the OB group presented higher concentrations of lEV enriched for endothelial and blood cell biomarkers than the HC group, but lower concentrations than those observed in the T2D group (P < .05). BS resulted in a significant reduction in most of the lEVs enriched for cell-specific markers in both subgroups. lEV differences between OB and T2D groups were no longer observed after BS (P > .05). However, compared with HC group, OB and T2D groups still showed increased concentrations of lEVs enriched for platelet and endothelial cell markers (P < .05).
+
+ CONCLUSION: At 1 year after BS, lEV concentrations remain above the physiological range. These abnormalities might contribute to explaining the increased CV risk after BS and underscore the importance of long-term CV risk factor control in post-BS individuals. Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1210%2fclinem%2fdgad473
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pane&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Effects+of+Bariatric+Surgery+on+Blood+and+Vascular+Large+Extracellular+Vesicles+According+to+Type+2+Diabetes+Status.&volume=109&issue=1&spage=e107&epage=e118&date=2023&doi=10.1210%2Fclinem%2Fdgad473&pmid=37589958&sid=OVID:medline
+
+<146>
+Unique Identifier
+ 37453087
+Title
+ Associations of Clinical Risk Factors and Novel Biomarkers With Age at Onset of Type 2 Diabetes.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 109(1):e321-e329, 2023 Dec 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen JX; Geng T; Zhang YB; Wang Y; Li R; Qiu Z; Wang Y; Yang K; Zhang BF; Ruan HL; Zhou YF; Pan A; Liu G; Liao YF
+Author NameID
+ Chen, Jun-Xiang; ORCID: https://orcid.org/0000-0001-8997-3439
+ Geng, Tingting; ORCID: https://orcid.org/0000-0002-6220-3968
+ Wang, Yi; ORCID: https://orcid.org/0000-0001-6965-9696
+ Zhou, Yan-Feng; ORCID: https://orcid.org/0000-0003-1967-1229
+ Pan, An; ORCID: https://orcid.org/0000-0002-1089-7945
+ Liu, Gang; ORCID: https://orcid.org/0000-0002-1430-3016
+ Liao, Yun-Fei; ORCID: https://orcid.org/0000-0003-0688-775X
+Authors Full Name
+ Chen, Jun-Xiang; Geng, Tingting; Zhang, Yan-Bo; Wang, Yi; Li, Rui; Qiu, Zixin; Wang, Yuexuan; Yang, Kun; Zhang, Bing-Fei; Ruan, Hua-Ling; Zhou, Yan-Feng; Pan, An; Liu, Gang; Liao, Yun-Fei.
+Institution
+ Chen, Jun-Xiang. Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Geng, Tingting. Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Zhang, Yan-Bo. Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Wang, Yi. Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Li, Rui. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Qiu, Zixin. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Wang, Yuexuan. Department of Applied Statistics, Johannes Kepler Universitat Linz, Linz, Austria.
+ Yang, Kun. Department of Endocrinology, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, China.
+ Zhang, Bing-Fei. Department of Endocrinology, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, China.
+ Ruan, Hua-Ling. Department of Endocrinology, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, China.
+ Zhou, Yan-Feng. Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Pan, An. Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Liu, Gang. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
+ Liao, Yun-Fei. Department of Endocrinology, Union Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
+MeSH Subject Headings
+ Humans
+ Middle Aged
+ Aged
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2
+ Age of Onset
+ Risk Factors
+ Obesity/ep [Epidemiology]
+ Obesity/co [Complications]
+ Biomarkers
+ Lipoproteins
+Keyword Heading
+ age at onset
+ biomarkers
+ cohort study
+ obesity
+ risk factors
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Younger onset of type 2 diabetes (T2D) was associated with higher risks of vascular complications and mortality.
+
+ OBJECTIVE: To prospectively assess risk profiles for incident T2D stratified by age at onset.
+
+ METHODS: A total of 471 269 participants free of T2D at baseline were included from the UK Biobank. Approximately 70 clinical, lipid, lipoprotein, inflammatory, and metabolic markers, and genetic risk scores (GRSs) were analyzed. Stratified Cox proportional-hazards regression models were used to estimate hazard ratios (HRs) for T2D with age of diagnosis divided into 4 groups (<=50.0, 50.1-60.0, 60.1-70.0, and >70.0 years).
+
+ RESULTS: During 11 years of follow-up, 15 805 incident T2D were identified. Among clinical risk factors, obesity had the highest HR at any age, ranging from 13.16 (95% CI, 9.67-17.91) for 50.0 years and younger to 4.13 (3.78-4.51) for older than 70.0 years. Other risks associated with T2D onset at age 50.0 years and younger included dyslipidemia (3.50, 2.91-4.20), hypertension (3.21, 2.71-3.80), cardiovascular disease (2.87, 2.13-3.87), parental history of diabetes (2.42, 2.04-2.86), education lower than college (1.89, 1.57-2.27), physical inactivity (1.73, 1.43-2.10), smoking (1.38, 1.13-1.68), several lipoprotein particles, inflammatory markers, liver enzymes, fatty acids, amino acids, as well as GRS. Associations of most risk factors and biomarkers were markedly attenuated with increasing age at onset (P interaction <.05), and some were not significant for onset at age older than 70.0 years, such as smoking, systolic blood pressure, and apolipoprotein B.
+
+ CONCLUSION: Most risk factors or biomarkers had stronger relative risks for T2D at younger ages, which emphasizes the necessity of promoting primary prevention among younger individuals. Moreover, obesity should be prioritized. Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipoproteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1210%2fclinem%2fdgad422
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Associations+of+Clinical+Risk+Factors+and+Novel+Biomarkers+With+Age+at+Onset+of+Type+2+Diabetes.&volume=109&issue=1&spage=e321&epage=e329&date=2023&doi=10.1210%2Fclinem%2Fdgad422&pmid=37453087&sid=OVID:medline
+
+<147>
+Unique Identifier
+ 38123207
+Title
+ [Risk prediction of metabolic syndrome and coronary artery disease in overweight and obese populations based on serum metabolomics]. [Chinese]
+Source
+ Chung-Hua Hsin Hsueh Kuan Ping Tsa Chih [Chinese Journal of Cardiology]. 51(12):1247-1255, 2023 Dec 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pei JY; Zhang DD; He H; Zheng LL; Du SZ; Jing ZW
+Authors Full Name
+ Pei, J Y; Zhang, D D; He, H; Zheng, L L; Du, S Z; Jing, Z W.
+Institution
+ Pei, J Y. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
+ Zhang, D D. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
+ He, H. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
+ Zheng, L L. Department of Traditional Chinese Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
+ Du, S Z. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
+ Jing, Z W. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
+MeSH Subject Headings
+ Humans
+ *Metabolic Syndrome
+ Overweight
+ *Coronary Artery Disease
+ Retrospective Studies
+ Cross-Sectional Studies
+ Obesity
+ Cholesterol, HDL
+ Biomarkers
+Abstract
+ Objective: By identifying different metabolites in the serum and clarifying the potential metabolic disorder pathways in metabolic syndrome (MS) and stable coronary artery disease patients, to evaluate the predictive value of specific metabolites based on serum metabolomics for the occurrence of MS and coronary heart disease in overweight or obese populations. Methods: This is a retrospective cross-sectional study. Patients with Metabolic Syndrome (MS group), patients with stable coronary heart disease (coronary heart disease group), and overweight or obese individuals (control group) recruited from the Central District of the First Affiliated Hospital of Zhengzhou University from 2017 to 2019 were assigned to the training set, meanwhile, the corresponding three groups of people recruited from the East District of the hospital during the same period were assigned to the validation test. The serum metabolomics profiles were determined by ultra-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS). Clinical characteristics (age, gender, body mass index (BMI), blood pressure, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), alanine aminotransferase (ALT), aspartate transaminase (AST), total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glomerular filtration rate (eGFR), creatinine (CR)) were also collected. Based on the orthogonal partial least-squares discrimination analysis (OPLS-DA) model, the significantly changed metabolites for MS and coronary artery disease patients were screened according to variable important in projection (VIP), and the receiver operating characteristic (ROC) analysis was evaluated for the risk prediction values of changed metabolites. Results: A total of 488 subjects were recruited in this study, the training set included 40 MS, 249 coronary artery disease patients and 148 controls, the validation set included 16 MS, 18 coronary artery disease patients and 17 controls. We made comparisons of the serum metabolites of coronary artery disease vs. controls, MS vs. controls, and coronary artery disease vs. MS, and a total of 22 different metabolites were identified. The disturbed metabolic pathways involved were phospholipid metabolism, amino acid metabolism, purine metabolism and other pathways. Through cross-comparisons, we identified 2 specific metabolites for MS (phosphatidylcholine (18:1(9Z)e/20) and pipecolic acid), 4 specific metabolites for coronary artery disease (lysophosphatidylcholine (17:0), PC(16:0/16:0), hypoxanthine and histidine), and 4 common metabolites both for MS and coronary artery disease (isoleucine, phenylalanine, glutathione and LysoPC(14:0)). Based on the cut-off values from ROC curve, the predictive value of the above metabolites for the occurrence of MS in overweight or obese populations is 100%, the predictive value for the occurrence of coronary heart disease is 87.5%, and the risk predictive value for coronary heart disease in MS patients is 82.1%. Conclusions: The altered serum metabolites suggest that MS and coronary heart disease may involve multiple metabolic pathway disorders. Specific metabolites based on serum metabolomics have good predictive value for the occurrence of MS and coronary heart disease in overweight or obese populations.
+Other Abstract
+ Publisher
+ : , (MS) , MS : 2017-2019 MS (MS ) ( ) ( ) , 3 - / , , (FPG) (HbA1c) (ALT) (AST) (eGFR) (CR) (OPLS-DA) , (VIP) MS (ROC) : 488 , MS 40 249 148 ; MS 16 18 17 MS MS , 22 , 2 MS [ (18:1(9Z)e/2:0) ] 4 [ (17:0) PC(16:0/16:0) ] 4 MS [ (14:0)] , MS 100%, 87.5%, MS 82.1% : MS MS .
+ Language: Chinese
+Registry Number/Name of Substance
+ 0 (Cholesterol, HDL). 0 (Biomarkers).
+Publication Type
+ English Abstract. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.3760%2fcma.j.cn112148-20231008-00254
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pei&issn=0253-3758&title=Chung-Hua+Hsin+Hsueh+Kuan+Ping+Tsa+Chih+%5BChinese+Journal+of+Cardiology%5D&atitle=%5BRisk+prediction+of+metabolic+syndrome+and+coronary+artery+disease+in+overweight+and+obese+populations+based+on+serum+metabolomics%5D.&volume=51&issue=12&spage=1247&epage=1255&date=2023&doi=10.3760%2Fcma.j.cn112148-20231008-00254&pmid=38123207&sid=OVID:medline
+
+<148>
+Unique Identifier
+ 37956617
+Title
+ High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer.
+Source
+ Gynecologic Oncology. 179:97-105, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baumann KE; Siamakpour-Reihani S; Dottino J; Dai Y; Bentley R; Jiang C; Zhang D; Sibley AB; Zhou C; Berchuck A; Owzar K; Bae-Jump V; Secord AA
+Authors Full Name
+ Baumann, Katherine E; Siamakpour-Reihani, Sharareh; Dottino, Joseph; Dai, Yanwan; Bentley, Rex; Jiang, Chen; Zhang, Dadong; Sibley, Alexander B; Zhou, Chunxiao; Berchuck, Andrew; Owzar, Kouros; Bae-Jump, Victoria; Secord, Angeles Alvarez.
+Institution
+ Baumann, Katherine E. Department of Obstetrics and Gynecology, Duke School of Medicine, Durham, NC, USA.
+ Siamakpour-Reihani, Sharareh. Department of Medicine, Duke School of Medicine, Durham, NC, USA.
+ Dottino, Joseph. Department of Medicine, Duke School of Medicine, Durham, NC, USA; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
+ Dai, Yanwan. Bioinformatics Shared Resource, Duke Cancer Institute, Durham, NC, USA.
+ Bentley, Rex. Department of Pathology, Duke School of Medicine, Durham, NC, USA.
+ Jiang, Chen. Bioinformatics Shared Resource, Duke Cancer Institute, Durham, NC, USA.
+ Zhang, Dadong. Bioinformatics Shared Resource, Duke Cancer Institute, Durham, NC, USA.
+ Sibley, Alexander B. Bioinformatics Shared Resource, Duke Cancer Institute, Durham, NC, USA.
+ Zhou, Chunxiao. Division of Gynecology Oncology, Department of Obstetrics and Gynecology, University of North Carolina in Chapel Hill, Chapel Hill, NC, USA.
+ Berchuck, Andrew. Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Duke School of Medicine, Durham, NC, USA.
+ Owzar, Kouros. Bioinformatics Shared Resource, Duke Cancer Institute, Durham, NC, USA; Department of Biostatistics and Bioinformatics, Duke School of Medicine, Durham, NC, USA.
+ Bae-Jump, Victoria. Division of Gynecology Oncology, Department of Obstetrics and Gynecology, University of North Carolina in Chapel Hill, Chapel Hill, NC, USA.
+ Secord, Angeles Alvarez. Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Duke School of Medicine, Durham, NC, USA. Electronic address: secor002@mc.duke.edu.
+MeSH Subject Headings
+ Humans
+ Mice
+ Animals
+ Female
+ Carcinoma, Ovarian Epithelial/ge [Genetics]
+ Carcinoma, Ovarian Epithelial/co [Complications]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ Obesity/ge [Genetics]
+ Obesity/co [Complications]
+ Ovarian Neoplasms/ge [Genetics]
+ Ovarian Neoplasms/co [Complications]
+ *Ovarian Neoplasms
+ Gene Expression
+ Biomarkers
+ Mice, Inbred C57BL
+Keyword Heading
+ And ovarian cancer
+ Angiogenesis
+ Body mass index
+ High-fat diet
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: We sought to evaluate the association between diet and angiogenic biomarkers in KpB mice, and the association between these markers, body mass index (BMI), and overall survival (OS) in high-grade serous cancers (HGSC).
+
+ METHODS: Tumors previously obtained from KpB mice subjected to high-fat diets (HFD, n = 10) or low-fat diets (LFD, n = 10) were evaluated for angiogenesis based on CD-31 microvessel density (MVD). Data from prior microarray analysis (Agilent 244 K arrays) conducted in 10 mice were utilized to assess associations between diet and angiogenetic biomarkers. Agilent (mouse) and Affymetrix Human Genome U133a probes were linked to 162 angiogenic-related genes. The associations between biomarkers, BMI, and OS were evaluated in an HGSC internal database (IDB) (n = 40). Genes with unadjusted p < 0.05 were evaluated for association with OS in the TCGA-OV database (n = 339).
+
+ RESULTS: There was no association between CD-31 and diet in mice (p = 0.66). Sixteen angiogenic-related genes passed the p < 0.05 threshold for association with HFD vs. LFD. Transforming growth factor-alpha (TGFA) demonstrated 72% higher expression in HFD vs. LFD mice (p = 0.04). Similar to the mouse study, in our HGSC IDB, higher TGFA expression correlated with higher BMI (p = 0.01) and shorter survival (p = 0.001). In the TCGA-OV dataset, BMI data was not available and there was no association between TGFA and OS (p = 0.48).
+
+ CONCLUSIONS: HFD and obesity may promote tumor progression via differential modulation of TGFA. We were unable to confirm this finding in the TCGA dataset. Further evaluation of TGFA is needed to determine if this is a target unique to obesity-driven HGSC. Copyright © 2023 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1016%2fj.ygyno.2023.11.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baumann&issn=0090-8258&title=Gynecologic+Oncology&atitle=High-fat+diet+and+obesity+are+associated+with+differential+angiogenic+gene+expression+in+epithelial+ovarian+cancer.&volume=179&issue=&spage=97&epage=105&date=2023&doi=10.1016%2Fj.ygyno.2023.11.002&pmid=37956617&sid=OVID:medline
+
+<149>
+Unique Identifier
+ 37963176
+Title
+ Effects of increasing light versus moderate-to-vigorous physical activity on cardiometabolic health in Chinese adults with obesity.
+Source
+ Journal of Sports Sciences. 41(16):1547-1557, 2023 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zheng C; Gill JMR; Sun FH; Huang WY; Sheridan S; Chen XK; Wu Y; Wong CK; Tian XY; Wong SH
+Author NameID
+ Wong, Stephen Heung-Sang; ORCID: https://orcid.org/0000-0002-6821-4545
+Authors Full Name
+ Zheng, Chen; Gill, Jason M R; Sun, Feng Hua; Huang, Wendy Yajun; Sheridan, Sinead; Chen, Xiang-Ke; Wu, Yalan; Wong, Chun-Kwok; Tian, Xiao Yu; Wong, Stephen Heung-Sang.
+Institution
+ Zheng, Chen. Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China.
+ Zheng, Chen. Department of Health and Physical Education, The Education University of Hong Kong, Hong Kong, China.
+ Gill, Jason M R. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
+ Sun, Feng Hua. Department of Health and Physical Education, The Education University of Hong Kong, Hong Kong, China.
+ Huang, Wendy Yajun. Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China.
+ Sheridan, Sinead. Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China.
+ Chen, Xiang-Ke. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
+ Wu, Yalan. School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
+ Wong, Chun-Kwok. Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China.
+ Tian, Xiao Yu. School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
+ Wong, Stephen Heung-Sang. Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China.
+MeSH Subject Headings
+ Adult
+ Humans
+ *E-Selectin
+ Sedentary Behavior
+ Obesity
+ Exercise
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Biomarkers
+ China
+ Waist Circumference
+Keyword Heading
+ Exercise
+ biomarkers
+ cardiovascular disease
+ endothelial function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Increasing daily physical activity (PA) is a practical way to decrease the risk of cardiometabolic diseases, while the studies on exercise intensity remain limited. The purpose of the present study was to compare the effects of increasing light PA (LPA) or moderate-to-vigorous PA (MVPA) for 12 weeks on cardiometabolic markers in Chinese adults with obesity. Fifty-three adults were randomly assigned to the 1) control group, 2) LPA group, and 3) MVPA group in free-living settings. The intervention effects on body composition, cardiorespiratory fitness, and cardiometabolic biomarkers were analysed using a generalized estimated equation model adjusted for baseline values and potential confounders. Compared with the control group, the MVPA group showed improvements in body composition, lipids, C-peptide, monocyte chemoattractant protein-1 (MCP-1), interleukin-8, leptin, and E-selectin. A favourable change in triglycerides and E-selectin were observed in the LPA group when compared to the control group. Lastly, improvements in waist circumference, C-reactive protein, and MCP-1 were observed in the MVPA group when compared to those in the LPA group. Although increasing both LPA and MVPA improved certain cardiometabolic biomarkers, the latter may have more benefits. These findings imply that MVPA may reduce cardiometabolic disease risk more effectively than LPA, especially in Chinese adults with obesity.
+Registry Number/Name of Substance
+ 0 (E-Selectin). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1080%2f02640414.2023.2282278
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zheng&issn=0264-0414&title=Journal+of+Sports+Sciences&atitle=Effects+of+increasing+light+versus+moderate-to-vigorous+physical+activity+on+cardiometabolic+health+in+Chinese+adults+with+obesity.&volume=41&issue=16&spage=1547&epage=1557&date=2023&doi=10.1080%2F02640414.2023.2282278&pmid=37963176&sid=OVID:medline
+
+<150>
+Unique Identifier
+ 37729955
+Title
+ Cell free ACE2 RNA: A potential biomarker of COVID-19 severity.
+Source
+ Respiratory Medicine. 219:107409, 2023 Nov-Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jalaleddine N; Gaudet M; Mogas A; Hachim M; Senok A; Saheb Sharif-Askari N; Mahboub B; Halwani R; Hamid Q; Al Heialy S
+Authors Full Name
+ Jalaleddine, Nour; Gaudet, Mellissa; Mogas, Andrea; Hachim, Mahmood; Senok, Abiola; Saheb Sharif-Askari, Narjes; Mahboub, Bassam; Halwani, Rabih; Hamid, Qutayba; Al Heialy, Saba.
+Institution
+ Jalaleddine, Nour. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
+ Gaudet, Mellissa. Meakins-Christie Laboratories, Research Institute of the McGill University Healthy Center, Montreal, Quebec, Canada.
+ Mogas, Andrea. Meakins-Christie Laboratories, Research Institute of the McGill University Healthy Center, Montreal, Quebec, Canada.
+ Hachim, Mahmood. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
+ Senok, Abiola. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
+ Saheb Sharif-Askari, Narjes. Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
+ Mahboub, Bassam. Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates; Department of Pulmonary Medicine and Allergy and Sleep Medicine, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates.
+ Halwani, Rabih. Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates; Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Paediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
+ Hamid, Qutayba. Meakins-Christie Laboratories, Research Institute of the McGill University Healthy Center, Montreal, Quebec, Canada; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
+ Al Heialy, Saba. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates; Meakins-Christie Laboratories, Research Institute of the McGill University Healthy Center, Montreal, Quebec, Canada. Electronic address: saba.alheialy@mbru.ac.ae.
+MeSH Subject Headings
+ Humans
+ Angiotensin-Converting Enzyme 2/ge [Genetics]
+ Biomarkers
+ *Cell-Free Nucleic Acids
+ COVID-19/di [Diagnosis]
+ *COVID-19
+ Obesity
+ Pandemics
+ RNA
+ SARS-CoV-2/ge [Genetics]
+Keyword Heading
+ ACE2
+ COVID-19
+ Cell-free RNA
+ Obesity
+ Severity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Despite the downward trend of COVID-19 pandemic and increased immunity of the general population, COVID-19 is still an elusive disease with risks due to emerging variants. Fast and reliable diagnosis of COVID-19 disease would allow better therapeutic interventions for patients at risk to develop more severe outcomes. Cell-free RNAs (cfRNAs) have been proven to be an effective biomarker in cancer and infectious diseases. It has been reported that cfRNAs are amplified in the bloodstream of these patients and at earlier stages of the disease, reflecting tissue damage. Hence, we hypothesize that cfRNAs may serve as a potential indicator of COVID-19 disease severity. To our knowledge, this is the first report to display a significant link between COVID-19 severity and cfRNA of angiotensin converting enzyme-2 (ACE2), the receptor for SARS-CoV-2 virus. qRT-PCR analysis of liquid biopsies from COVID-19 patients (n = 82) displayed a significant increase in ACE2-cfRNA levels in patients with severe manifestations. This finding correlated with blood biomarkers (ANC, WBC, and Creatinine) that were also significantly increased in these patients. We previously showed that bronchial cells from obese subjects express higher ACE2 levels, hence, we further analysed the involvement of obesity as a main contributor to severe outcomes. We confirm a significant increase of ACE2-cfRNA in the plasma of obese/overweight (Ob/Ov) COVID-19 patients compared to lean subjects, with no observed significant change in blood biomarkers. These findings suggest that monitoring ACE2-cfRNAs, as a biomarker, during COVID-19 infection may allow for better disease management, specifically for severe-COVID-19 patients. Copyright © 2023 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ EC 3-4-17-23 (Angiotensin-Converting Enzyme 2). 0 (Biomarkers). 0 (Cell-Free Nucleic Acids). 63231-63-0 (RNA). EC 3-4-17-23 (ACE2 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.rmed.2023.107409
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jalaleddine&issn=0954-6111&title=Respiratory+Medicine&atitle=Cell+free+ACE2+RNA%3A+A+potential+biomarker+of+COVID-19+severity.&volume=219&issue=&spage=107409&epage=&date=2023&doi=10.1016%2Fj.rmed.2023.107409&pmid=37729955&sid=OVID:medline
+
+<151>
+Unique Identifier
+ 37271698
+Title
+ Relationship Between Pretreatment Body Composition and Clinical Outcomes in Patients With Metastatic Renal Cell Carcinoma Receiving First-Line Ipilimumab Plus Nivolumab.
+Source
+ Clinical Genitourinary Cancer. 21(6):e429-e437.e2, 2023 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ McManus HD; Zhang D; Schwartz FR; Wu Y; Infield J; Ho E; Armstrong AJ; George DJ; Kruse D; Gupta RT; Harrison MR
+Authors Full Name
+ McManus, Hannah D; Zhang, Dylan; Schwartz, Fides R; Wu, Yuan; Infield, Jordan; Ho, Ethan; Armstrong, Andrew J; George, Daniel J; Kruse, Danielle; Gupta, Rajan T; Harrison, Michael R.
+Institution
+ McManus, Hannah D. Department of Medicine, Duke University Medical Center, Durham, NC. Electronic address: hannah.dzimitrowicz@duke.edu.
+ Zhang, Dylan. Department of Radiology, Duke University Medical Center, Durham, NC.
+ Schwartz, Fides R. Department of Radiology, Duke University Medical Center, Durham, NC.
+ Wu, Yuan. Department of Biostatics and Bioinformatics, Duke University, Durham, NC.
+ Infield, Jordan. Department of Medicine, Duke University Medical Center, Durham, NC.
+ Ho, Ethan. Department of Biomedical Engineering, Duke University, Durham, NC.
+ Armstrong, Andrew J. Department of Medicine, Duke University Medical Center, Durham, NC; Duke Cancer Institute Center for Prostate and Urologic Cancers, Durham, NC; Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC.
+ George, Daniel J. Department of Medicine, Duke University Medical Center, Durham, NC; Duke Cancer Institute Center for Prostate and Urologic Cancers, Durham, NC; Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC.
+ Kruse, Danielle. Department of Radiology, Duke University Medical Center, Durham, NC.
+ Gupta, Rajan T. Department of Radiology, Duke University Medical Center, Durham, NC; Department of Surgery, Division of Urology, Duke Cancer Institute, Durham, NC; Duke Cancer Institute Center for Prostate and Urologic Cancers, Durham, NC.
+ Harrison, Michael R. Department of Medicine, Duke University Medical Center, Durham, NC; Duke Cancer Institute Center for Prostate and Urologic Cancers, Durham, NC; Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ Carcinoma, Renal Cell/pa [Pathology]
+ *Carcinoma, Renal Cell
+ Nivolumab/tu [Therapeutic Use]
+ Ipilimumab/tu [Therapeutic Use]
+ Kidney Neoplasms/dt [Drug Therapy]
+ Kidney Neoplasms/pa [Pathology]
+ *Kidney Neoplasms
+ Overweight/ci [Chemically Induced]
+ Overweight/dt [Drug Therapy]
+ Retrospective Studies
+ Obesity
+ Body Composition
+ Biomarkers
+Keyword Heading
+ Adiposity
+ biomarker
+ immunotherapy
+ kidney cancer
+ sarcopenia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Biomarkers are needed to identify patients with metastatic renal cell carcinoma (mRCC) most likely to benefit from immune checkpoint inhibitors. We examined associations between radiographically assessed body composition (BC) variables and body mass index (BMI) with clinical outcomes for patients with mRCC receiving first-line ipilimumab + nivolumab (ipi/nivo).
+
+ PATIENTS AND METHODS: We retrospectively reviewed all patients with mRCC treated with first-line ipi/nivo at one institution before June 1, 2021 with an analyzable baseline computed tomography (CT) scan. BC variables (skeletal muscle index [SMI], subcutaneous adipose tissue index [SATI], and visceral adipose tissue index [VATI]) were measured using baseline CT scans. Relationships between BC variables and clinical outcomes were examined using Cox proportional hazard regression models.
+
+ RESULTS: Ninety-nine patients were analyzed (74% male, 64% overweight/obese, 75% low SMI). Controlling for age, IMDC risk, and sex (for BMI analyses), high vs. low SMI (HR=2.433, CI: 1.397-4.238, P=.0017), high vs. low SATI (HR=1.641, CI: 1.023-2.632, P=.0398), and obese BMI (>= 30 kg/m2) vs. normal/overweight BMI (<30 kg/m2) (HR=1.859, CI: 1.156-2.989, P=.0105) were significantly associated with progression-free survival (PFS). Median overall survival (OS) for low SMI patients was higher (42.74 months, CI: 26.84, NR) than median OS for high SMI patients (27.01 months, CI: 15.28, NR) (adjusted HR=1.728, CI: 0.909-3.285, P=.0952). No BC variables were significantly associated with OS or objective response rate.
+
+ CONCLUSIONS: Low SMI and low SATI were associated with significantly better PFS for patients with mRCC receiving first-line ipi/nivo. Radiographic BC variables may be useful prognostic biomarkers in this setting. Copyright © 2023 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 31YO63LBSN (Nivolumab). 0 (Ipilimumab). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.clgc.2023.05.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=McManus&issn=1558-7673&title=Clinical+Genitourinary+Cancer&atitle=Relationship+Between+Pretreatment+Body+Composition+and+Clinical+Outcomes+in+Patients+With+Metastatic+Renal+Cell+Carcinoma+Receiving+First-Line+Ipilimumab+Plus+Nivolumab.&volume=21&issue=6&spage=e429&epage=e437.e2&date=2023&doi=10.1016%2Fj.clgc.2023.05.006&pmid=37271698&sid=OVID:medline
+
+<152>
+Unique Identifier
+ 37902008
+Title
+ Next Generation, Modifiable Cardiometabolic Biomarkers: Mitochondrial Adaptation and Metabolic Resilience: A Scientific Statement From the American Heart Association. [Review]
+Source
+ Circulation. 148(22):1827-1845, 2023 11 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mietus-Snyder M; Perak AM; Cheng S; Hayman LL; Haynes N; Meikle PJ; Shah SH; Suglia SF
+Corporate Author
+ American Heart Association Atherosclerosis, Hypertension and Obesity in the Young Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Cardiovascular and Stroke Nursing
+Authors Full Name
+ Mietus-Snyder, Michele; Perak, Amanda M; Cheng, Susan; Hayman, Laura L; Haynes, Norrisa; Meikle, Peter J; Shah, Svati H; Suglia, Shakira F.
+MeSH Subject Headings
+ Child
+ Adolescent
+ Humans
+ *American Heart Association
+ Risk Factors
+ Obesity/co [Complications]
+ Biomarkers
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+Keyword Heading
+ AHA Scientific Statements
+ biomarkers
+ child health
+ inflammasomes
+ lipidomics
+ metabolome
+ microbiome
+ microbiota
+ mitochondria
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cardiometabolic risk is increasing in prevalence across the life span with disproportionate ramifications for youth at socioeconomic disadvantage. Established risk factors and associated disease progression are harder to reverse as they become entrenched over time; if current trends are unchecked, the consequences for individual and societal wellness will become untenable. Interrelated root causes of ectopic adiposity and insulin resistance are understood but identified late in the trajectory of systemic metabolic dysregulation when traditional cardiometabolic risk factors cross current diagnostic thresholds of disease. Thus, children at cardiometabolic risk are often exposed to suboptimal metabolism over years before they present with clinical symptoms, at which point life-long reliance on pharmacotherapy may only mitigate but not reverse the risk. Leading-edge indicators are needed to detect the earliest departure from healthy metabolism, so that targeted, primordial, and primary prevention of cardiometabolic risk is possible. Better understanding of biomarkers that reflect the earliest transitions to dysmetabolism, beginning in utero, ideally biomarkers that are also mechanistic/causal and modifiable, is critically needed. This scientific statement explores emerging biomarkers of cardiometabolic risk across rapidly evolving and interrelated "omic" fields of research (the epigenome, microbiome, metabolome, lipidome, and inflammasome). Connections in each domain to mitochondrial function are identified that may mediate the favorable responses of each of the omic biomarkers featured to a heart-healthy lifestyle, notably to nutritional interventions. Fuller implementation of evidence-based nutrition must address environmental and socioeconomic disparities that can either facilitate or impede response to therapy.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1161%2fCIR.0000000000001185
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mietus-Snyder&issn=0009-7322&title=Circulation&atitle=Next+Generation%2C+Modifiable+Cardiometabolic+Biomarkers%3A+Mitochondrial+Adaptation+and+Metabolic+Resilience%3A+A+Scientific+Statement+From+the+American+Heart+Association.&volume=148&issue=22&spage=1827&epage=1845&date=2023&doi=10.1161%2FCIR.0000000000001185&pmid=37902008&sid=OVID:medline
+
+<153>
+Unique Identifier
+ 37477690
+Title
+ Cardiovascular risk factors during pregnancy impact the postpartum cardiac and vascular reverse remodeling.
+Source
+ American Journal of Physiology - Heart & Circulatory Physiology. 325(4):H774-H789, 2023 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ferreira AF; Azevedo MJ; Morais J; Trindade F; Saraiva F; Diaz SO; Alves IN; Fragao-Marques M; Sousa C; Machado AP; Leite-Moreira A; Sampaio-Maia B; Ramalho C; Barros AS; Falcao-Marques I
+Author NameID
+ Ferreira, Ana Filipa; ORCID: https://orcid.org/0000-0003-2080-309X
+ Azevedo, Maria Joao; ORCID: https://orcid.org/0000-0002-9117-4684
+ Trindade, Fabio; ORCID: https://orcid.org/0000-0002-3415-2040
+ Saraiva, Francisca; ORCID: https://orcid.org/0000-0001-7961-9962
+ Diaz, Silvia Oliveira; ORCID: https://orcid.org/0000-0002-5046-8993
+ Ramalho, Carla; ORCID: https://orcid.org/0000-0002-3977-3946
+ Barros, Antonio Sousa; ORCID: https://orcid.org/0000-0002-9103-5852
+Authors Full Name
+ Ferreira, Ana Filipa; Azevedo, Maria Joao; Morais, Juliana; Trindade, Fabio; Saraiva, Francisca; Diaz, Silvia Oliveira; Alves, Ines Nuno; Fragao-Marques, Mariana; Sousa, Carla; Machado, Ana Paula; Leite-Moreira, Adelino; Sampaio-Maia, Benedita; Ramalho, Carla; Barros, Antonio Sousa; Falcao-Marques, Ines.
+Institution
+ Ferreira, Ana Filipa. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Azevedo, Maria Joao. Faculdade de Medicina Dentaria, Universidade do Porto, Porto, Portugal.
+ Azevedo, Maria Joao. INEB-Instituto Nacional de Engenharia Biomedica, Porto, Portugal.
+ Azevedo, Maria Joao. i3S-Instituto de Investigacao e Inovacao em Saude, Universidade do Porto, Porto, Portugal.
+ Azevedo, Maria Joao. Academic Center for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
+ Morais, Juliana. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Trindade, Fabio. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Saraiva, Francisca. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Diaz, Silvia Oliveira. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Alves, Ines Nuno. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Fragao-Marques, Mariana. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Fragao-Marques, Mariana. Department of Clinical Pathology, Centro Hospitalar de Sao Joao, Porto, Portugal.
+ Sousa, Carla. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Sousa, Carla. Department of Cardiology, Centro Hospitalar de Sao Joao, Porto, Portugal.
+ Machado, Ana Paula. Center of Prenatal Diagnosis, Department of Obstetrics, Centro Hospitalar de Sao Joao, Porto, Portugal.
+ Leite-Moreira, Adelino. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Leite-Moreira, Adelino. Department of Cardiothoracic Surgery, Centro Hospitalar de Sao Joao, Porto, Portugal.
+ Sampaio-Maia, Benedita. Faculdade de Medicina Dentaria, Universidade do Porto, Porto, Portugal.
+ Sampaio-Maia, Benedita. INEB-Instituto Nacional de Engenharia Biomedica, Porto, Portugal.
+ Sampaio-Maia, Benedita. i3S-Instituto de Investigacao e Inovacao em Saude, Universidade do Porto, Porto, Portugal.
+ Ramalho, Carla. Center of Prenatal Diagnosis, Department of Obstetrics, Centro Hospitalar de Sao Joao, Porto, Portugal.
+ Ramalho, Carla. Department of Obstetrics, Gynaecology and Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal.
+ Barros, Antonio Sousa. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+ Falcao-Marques, Ines. Department of Surgery and Physiology, Cardiovascular R&D Centre-UnIC@RISE, Faculdade de Medicina, University of Porto, Porto, Portugal.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Pregnancy
+ Female
+ Humans
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Prospective Studies
+ *Diabetes, Gestational
+ Interleukin-1 Receptor-Like 1 Protein
+ Interleukin-33
+ Risk Factors
+ Postpartum Period
+ *Hypertension
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Cardiomegaly
+ Biomarkers
+ Heart Disease Risk Factors
+Keyword Heading
+ cardiovascular remodeling
+ cardiovascular risk factors
+ postpartum
+ pregnancy
+ reverse remodeling
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pregnant women with cardiovascular risk (CVR) factors are highly prone to develop cardiovascular disease later in life. Thus, recent guidelines suggest extending the follow-up period to 1 yr after delivery. We aimed to evaluate cardiovascular remodeling during pregnancy and determine which CVR factors and potential biomarkers predict postpartum cardiac and vascular reverse remodeling (RR). Our study included a prospective cohort of 76 healthy and 54 obese and/or hypertensive and/or with gestational diabetes pregnant women who underwent transthoracic echocardiography, pulse-wave velocity (PWV), and blood collection at the 1st trimester (1T) and 3rd trimester (3T) of pregnancy as well as at the 1st/6th/12th mo after delivery. Generalized linear mixed-effects models was used to evaluate the extent of RR and its potential predictors. Pregnant women develop cardiac hypertrophy, as confirmed by a significant increase in left ventricular mass (LVM). Moreover, ventricular filling pressure (E/e') and atrial volume increased significantly during gestation. Significant regression of left ventricular (LV) volume, LVM, and filling pressures was observed as soon as 1 mo postpartum. The LV global longitudinal strain worsened slightly and recovered at 6 mo postpartum. PWV decreased significantly from 1T to 3T and normalized at 1 mo postpartum. We found that arterial hypertension, smoking habits, and obesity were independent predictors of increased LVM during pregnancy and postpartum. High C-reactive protein (CRP) and low ST2/IL33-receptor levels are potential circulatory biomarkers of worse LVM regression. Arterial hypertension, age, and gestational diabetes positively correlated with PWV. Altogether, our findings pinpoint arterial hypertension as a critical risk factor for worse RR and CRP, and ST2/IL33 receptors as potential biomarkers of postpartum hypertrophy reversal. NEW & NOTEWORTHY This study describes the impact of cardiovascular risk factors (CVR) in pregnancy-induced remodeling and postpartum reverse remodeling (up to 1 yr) by applying advanced statistic methods (multivariate generalized linear mixed-effects models) to a prospective cohort of pregnant women. Aiming to extrapolate to pathological conditions, this invaluable "human model" allowed us to demonstrate that arterial hypertension is a critical CVR for worse RR and that ST2/IL33-receptors and CRP are potential biomarkers of postpartum hypertrophy reversal.
+Registry Number/Name of Substance
+ 0 (Interleukin-1 Receptor-Like 1 Protein). 0 (Interleukin-33). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1152%2fajpheart.00200.2023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ferreira&issn=0363-6135&title=American+Journal+of+Physiology+-+Heart+%26+Circulatory+Physiology&atitle=Cardiovascular+risk+factors+during+pregnancy+impact+the+postpartum+cardiac+and+vascular+reverse+remodeling.&volume=325&issue=4&spage=H774&epage=H789&date=2023&doi=10.1152%2Fajpheart.00200.2023&pmid=37477690&sid=OVID:medline
+
+<154>
+Unique Identifier
+ 37703087
+Title
+ Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF.
+Source
+ Circulation: Heart Failure. 16(11):e010618, 2023 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ramirez MF; Lau ES; Parekh JK; Pan AS; Owunna N; Wang D; McNeill JN; Malhotra R; Nayor M; Lewis GD; Ho JE
+Author NameID
+ Ramirez, Mariana F; ORCID: https://orcid.org/0000-0002-1643-7894
+ Lau, Emily S; ORCID: https://orcid.org/0000-0001-9361-6397
+ Parekh, Juhi K; ORCID: https://orcid.org/0009-0009-6510-0073
+ McNeill, Jenna N; ORCID: https://orcid.org/0000-0001-7032-4228
+ Malhotra, Rajeev; ORCID: https://orcid.org/0000-0003-0120-4630
+ Nayor, Matthew; ORCID: https://orcid.org/0000-0002-6993-9396
+ Lewis, Gregory D; ORCID: https://orcid.org/0000-0001-8108-8240
+ Ho, Jennifer E; ORCID: https://orcid.org/0000-0002-7987-4768
+Authors Full Name
+ Ramirez, Mariana F; Lau, Emily S; Parekh, Juhi K; Pan, Abigail S; Owunna, Ndidi; Wang, Dongyu; McNeill, Jenna N; Malhotra, Rajeev; Nayor, Matthew; Lewis, Gregory D; Ho, Jennifer E.
+Institution
+ Ramirez, Mariana F. Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (M.F.R., J.K.P., A.S.P., N.O., D.W., J.E.H.).
+ Lau, Emily S. Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (E.S.L., J.N.M., R.M., G.D.L.).
+ Parekh, Juhi K. Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (M.F.R., J.K.P., A.S.P., N.O., D.W., J.E.H.).
+ Pan, Abigail S. Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (M.F.R., J.K.P., A.S.P., N.O., D.W., J.E.H.).
+ Owunna, Ndidi. Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (M.F.R., J.K.P., A.S.P., N.O., D.W., J.E.H.).
+ Wang, Dongyu. Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (M.F.R., J.K.P., A.S.P., N.O., D.W., J.E.H.).
+ Wang, Dongyu. Department of Biostatistics, Boston University School of Public Health, MA (D.W.).
+ McNeill, Jenna N. Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (E.S.L., J.N.M., R.M., G.D.L.).
+ McNeill, Jenna N. Pulmonary and Critical Care, Division of Massachusetts General Hospital, Boston (J.N.M.).
+ Malhotra, Rajeev. Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (E.S.L., J.N.M., R.M., G.D.L.).
+ Nayor, Matthew. Sections of Cardiovascular Medicine and Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, MA (M.N.).
+ Lewis, Gregory D. Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (E.S.L., J.N.M., R.M., G.D.L.).
+ Ho, Jennifer E. Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (M.F.R., J.K.P., A.S.P., N.O., D.W., J.E.H.).
+MeSH Subject Headings
+ Humans
+ Heart Failure/di [Diagnosis]
+ *Heart Failure
+ Stroke Volume/ph [Physiology]
+ Leptin
+ Resistin
+ Adiponectin
+ Ventricular Function, Left/ph [Physiology]
+ *Insulin Resistance
+ Interleukin-6
+ Obesity/co [Complications]
+ Biomarkers
+ Exercise Test
+ Exercise Tolerance/ph [Physiology]
+Keyword Heading
+ adiposity
+ biomarker
+ heart failure
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity and adiposity are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF); yet, specific underlying mechanisms remain unclear. We sought to examine the association of obesity-related biomarkers including adipokines (leptin, resistin, adiponectin), inflammatory markers (CRP [C-reactive protein], IL-6 [interleukin-6]), and insulin resistance (HOMA-IR) with HFpEF status, exercise capacity, and cardiovascular outcomes.
+
+ METHODS: We studied 509 consecutive patients with left ventricular ejection fraction >=50% and chronic dyspnea, who underwent clinically indicated cardiopulmonary exercise test with invasive hemodynamic monitoring between 2006 and 2017. We defined HFpEF based on the presence of elevated left ventricular filling pressures at rest or during exercise. Fasting blood samples collected at the time of the cardiopulmonary exercise test were used to assay obesity-related biomarkers. We examined the association of log-transformed biomarkers with HFpEF status and exercise traits using multivariable-adjusted logistic regression models.
+
+ RESULTS: We observed associations of obesity-related biomarkers with measures of impaired exercise capacity including peak VO2 (P<=0.002 for all biomarkers). The largest effect size was seen with leptin, where a 1-SD higher leptin was associated with a 2.35 mL/kg per min lower peak VO2 (beta, -2.35+/-0.19; P<0.001). In addition, specific biomarkers were associated with distinct measures of exercise reserve including blood pressure (homeostatic model assessment of insulin resistance, leptin, adiponectin; P<=0.002 for all), and chronotropic response (CRP, IL-6, homeostatic model assessment of insulin resistance, leptin, and resistin; P<0.05 for all). Our findings suggest that among the obesity-related biomarkers studied, higher levels of leptin and CRP are independently associated with increased odds of HFpEF, with odds ratios of 1.36 (95% CI, 1.09-1.70) and 1.25 (95% CI, 1.03-1.52), respectively.
+
+ CONCLUSIONS: Specific obesity-related pathways including inflammation, adipokine signaling, and insulin resistance may underlie the association of obesity with HFpEF and exercise intolerance.
+Registry Number/Name of Substance
+ 0 (Leptin). 0 (Resistin). 0 (Adiponectin). 0 (Interleukin-6). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1161%2fCIRCHEARTFAILURE.123.010618
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ramirez&issn=1941-3289&title=Circulation%3A+Heart+Failure&atitle=Obesity-Related+Biomarkers+Are+Associated+With+Exercise+Intolerance+and+HFpEF.&volume=16&issue=11&spage=e010618&epage=&date=2023&doi=10.1161%2FCIRCHEARTFAILURE.123.010618&pmid=37703087&sid=OVID:medline
+
+<155>
+Unique Identifier
+ 38034016
+Title
+ Proteome profiling identifies circulating biomarkers associated with hepatic steatosis in subjects with Prader-Willi syndrome.
+Source
+ Frontiers in Endocrinology. 14:1254778, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pascut D; Giraudi PJ; Banfi C; Ghilardi S; Tiribelli C; Bondesan A; Caroli D; Minocci A; Grugni G; Sartorio A
+Authors Full Name
+ Pascut, Devis; Giraudi, Pablo J; Banfi, Cristina; Ghilardi, Stefania; Tiribelli, Claudio; Bondesan, Adele; Caroli, Diana; Minocci, Alessandro; Grugni, Graziano; Sartorio, Alessandro.
+Institution
+ Pascut, Devis. Liver Cancer Unit, Fondazione Italiana Fegato - ONLUS, Trieste, Italy.
+ Giraudi, Pablo J. Metabolic Liver Disease Unit, Fondazione Italiana Fegato - ONLUS, Trieste, Italy.
+ Banfi, Cristina. Unit of Functional Proteomics, Metabolomics, and Network analysis, Centro Cardiologico Monzino, IRCCS, Milan, Italy.
+ Ghilardi, Stefania. Unit of Functional Proteomics, Metabolomics, and Network analysis, Centro Cardiologico Monzino, IRCCS, Milan, Italy.
+ Tiribelli, Claudio. Liver Cancer Unit, Fondazione Italiana Fegato - ONLUS, Trieste, Italy.
+ Tiribelli, Claudio. Metabolic Liver Disease Unit, Fondazione Italiana Fegato - ONLUS, Trieste, Italy.
+ Bondesan, Adele. Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Experimental Laboratory for Auxo-endocrinological Research, Piancavallo-Verbania, Italy.
+ Caroli, Diana. Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Experimental Laboratory for Auxo-endocrinological Research, Piancavallo-Verbania, Italy.
+ Minocci, Alessandro. Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Division of Metabolic Diseases, Piancavallo-Verbania, Italy.
+ Grugni, Graziano. Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Experimental Laboratory for Auxo-endocrinological Research, Piancavallo-Verbania, Italy.
+ Grugni, Graziano. Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Division of Auxology, Piancavallo-Verbania, Italy.
+ Sartorio, Alessandro. Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Experimental Laboratory for Auxo-endocrinological Research, Piancavallo-Verbania, Italy.
+MeSH Subject Headings
+ Humans
+ Prader-Willi Syndrome/co [Complications]
+ Prader-Willi Syndrome/di [Diagnosis]
+ Prader-Willi Syndrome/ge [Genetics]
+ *Prader-Willi Syndrome
+ Proteome
+ Obesity/co [Complications]
+ Fatty Liver/di [Diagnosis]
+ *Fatty Liver
+ Biomarkers
+ Membrane Proteins
+ Nerve Tissue Proteins
+Keyword Heading
+ MAFLD CDH2
+ PWS
+ cardiovascular
+ circulating biomarkers
+ metabolic
+ proteome
+ proteomics
+ steatosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction: Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by loss of expression of paternal chromosome 15q11.2-q13 genes. Individuals with PWS exhibit unique physical, endocrine, and metabolic traits associated with severe obesity. Identifying liver steatosis in PWS is challenging, despite its lower prevalence compared to non-syndromic obesity. Reliable biomarkers are crucial for the early detection and management of this condition associated with the complex metabolic profile and cardiovascular risks in PWS.
+
+ Methods: Circulating proteome profiling was conducted in 29 individuals with PWS (15 with steatosis, 14 without) using the Olink Target 96 metabolism and cardiometabolic panels. Correlation analysis was performed to identify the association between protein biomarkes and clinical variables, while the gene enrichment analysis was conducted to identify pathways linked to deregulated proteins. Receiver operating characteristic (ROC) curves assessed the discriminatory power of circulating protein while a logistic regression model evaluated the potential of a combination of protein biomarkers.
+
+ Results: CDH2, CTSO, QDPR, CANT1, ALDH1A1, TYMP, ADGRE, KYAT1, MCFD, SEMA3F, THOP1, TXND5, SSC4D, FBP1, and CES1 exhibited a significant differential expression in liver steatosis, with a progressive increase from grade 1 to grade 3. FBP1, CES1, and QDPR showed predominant liver expression. The logistic regression model, -34.19 + 0.85 * QDPR*QDPR + 0.75 * CANT1*TYMP - 0.46 * THOP1*ALDH1A, achieved an AUC of 0.93 (95% CI: 0.63-0.99), with a sensitivity of 93% and specificity of 80% for detecting steatosis in individuals with PWS. These biomarkers showed strong correlations among themselves and were involved in an interconnected network of 62 nodes, related to seven metabolic pathways. They were also significantly associated with cholesterol, LDL, triglycerides, transaminases, HbA1c, FLI, APRI, and HOMA, and showed a negative correlation with HDL levels.
+
+ Conclusion: The biomarkers identified in this study offer the potential for improved patient stratification and personalized therapeutic protocols. Copyright © 2023 Pascut, Giraudi, Banfi, Ghilardi, Tiribelli, Bondesan, Caroli, Minocci, Grugni and Sartorio.
+Registry Number/Name of Substance
+ 0 (Proteome). 0 (Biomarkers). 0 (SEMA3F protein, human). 0 (Membrane Proteins). 0 (Nerve Tissue Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3389%2ffendo.2023.1254778
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pascut&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Proteome+profiling+identifies+circulating+biomarkers+associated+with+hepatic+steatosis+in+subjects+with+Prader-Willi+syndrome.&volume=14&issue=&spage=1254778&epage=&date=2023&doi=10.3389%2Ffendo.2023.1254778&pmid=38034016&sid=OVID:medline
+
+<156>
+Unique Identifier
+ 37368983
+Title
+ Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study.
+Source
+ Diabetes Care. 46(8):1531-1540, 2023 08 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Brown OI; Drozd M; McGowan H; Giannoudi M; Conning-Rowland M; Gierula J; Straw S; Wheatcroft SB; Bridge K; Roberts LD; Levelt E; Ajjan R; Griffin KJ; Bailey MA; Kearney MT; Cubbon RM
+Author NameID
+ Brown, Oliver I; ORCID: https://orcid.org/0000-0001-7555-476X
+ Wheatcroft, Stephen B; ORCID: https://orcid.org/0000-0002-6741-9012
+ Roberts, Lee D; ORCID: https://orcid.org/0000-0002-1455-5248
+ Ajjan, Ramzi; ORCID: https://orcid.org/0000-0002-1636-3725
+ Kearney, Mark T; ORCID: https://orcid.org/0000-0002-9376-8814
+ Cubbon, Richard M; ORCID: https://orcid.org/0000-0001-7844-3600
+Authors Full Name
+ Brown, Oliver I; Drozd, Michael; McGowan, Hugo; Giannoudi, Marilena; Conning-Rowland, Marcella; Gierula, John; Straw, Sam; Wheatcroft, Stephen B; Bridge, Katherine; Roberts, Lee D; Levelt, Eylem; Ajjan, Ramzi; Griffin, Kathryn J; Bailey, Marc A; Kearney, Mark T; Cubbon, Richard M.
+Institution
+ Brown, Oliver I. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Drozd, Michael. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ McGowan, Hugo. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Giannoudi, Marilena. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Conning-Rowland, Marcella. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Gierula, John. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Straw, Sam. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Wheatcroft, Stephen B. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Bridge, Katherine. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Roberts, Lee D. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Levelt, Eylem. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Ajjan, Ramzi. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Griffin, Kathryn J. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Bailey, Marc A. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Kearney, Mark T. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+ Cubbon, Richard M. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.
+MeSH Subject Headings
+ Humans
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Overweight/co [Complications]
+ Cohort Studies
+ Carotid Intima-Media Thickness
+ Biological Specimen Banks
+ Stroke Volume
+ Risk Factors
+ Body Mass Index
+ Ventricular Function, Left
+ Obesity/ep [Epidemiology]
+ *Diabetes Mellitus
+ Myocardial Infarction/co [Complications]
+ *Myocardial Infarction
+ Phenotype
+ Biomarkers
+ Ischemic Stroke/co [Complications]
+ *Ischemic Stroke
+ United Kingdom/ep [Epidemiology]
+Abstract
+ OBJECTIVE: Obesity and diabetes frequently coexist, yet their individual contributions to cardiovascular risk remain debated. We explored cardiovascular disease biomarkers, events, and mortality in the UK Biobank stratified by BMI and diabetes.
+
+ RESEARCH DESIGN AND METHODS: A total of 451,355 participants were stratified by ethnicity-specific BMI categories (normal, overweight, obese) and diabetes status. We examined cardiovascular biomarkers including carotid intima-media thickness (CIMT), arterial stiffness, left ventricular ejection fraction (LVEF), and cardiac contractility index (CCI). Poisson regression models estimated adjusted incidence rate ratios (IRRs) for myocardial infarction, ischemic stroke, and cardiovascular death, with normal-weight nondiabetes as comparator.
+
+ RESULTS: Five percent of participants had diabetes (10% normal weight, 34% overweight, and 55% obese vs. 34%, 43%, and 23%, respectively, without diabetes). In the nondiabetes group, overweight/obesity was associated with higher CIMT, arterial stiffness, and CCI and lower LVEF (P < 0.005); these relationships were diminished in the diabetes group. Within BMI classes, diabetes was associated with adverse cardiovascular biomarker phenotype (P < 0.005), particularly in the normal-weight group. After 5,323,190 person-years follow-up, incident myocardial infarction, ischemic stroke, and cardiovascular mortality rose across increasing BMI categories without diabetes (P < 0.005); this was comparable in the diabetes groups (P-interaction > 0.05). Normal-weight diabetes had comparable adjusted cardiovascular mortality to obese nondiabetes (IRR 1.22 [95% CI 0.96-1.56]; P = 0.1).
+
+ CONCLUSIONS: Obesity and diabetes are additively associated with adverse cardiovascular biomarkers and mortality risk. While adiposity metrics are more strongly correlated with cardiovascular biomarkers than diabetes-oriented metrics, both correlate weakly, suggesting that other factors underpin the high cardiovascular risk of normal-weight diabetes. Copyright © 2023 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.2337%2fdc23-0294
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Brown&issn=0149-5992&title=Diabetes+Care&atitle=Relationship+Among+Diabetes%2C+Obesity%2C+and+Cardiovascular+Disease+Phenotypes%3A+A+UK+Biobank+Cohort+Study.&volume=46&issue=8&spage=1531&epage=1540&date=2023&doi=10.2337%2Fdc23-0294&pmid=37368983&sid=OVID:medline
+
+<157>
+Unique Identifier
+ 37368513
+Title
+ A low-energy total diet replacement program demonstrates a favorable safety profile and improves liver disease severity in nonalcoholic steatohepatitis.
+Source
+ Obesity. 31(7):1767-1778, 2023 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Koutoukidis DA; Mozes FE; Jebb SA; Tomlinson JW; Pavlides M; Saffioti F; Huntriss R; Aveyard P; Cobbold JF
+Author NameID
+ Koutoukidis, Dimitrios A; ORCID: https://orcid.org/0000-0002-1955-7234
+ Mozes, Ferenc E; ORCID: https://orcid.org/0000-0002-1361-4349
+ Jebb, Susan A; ORCID: https://orcid.org/0000-0001-9190-2920
+ Tomlinson, Jeremy W; ORCID: https://orcid.org/0000-0002-3170-8533
+ Pavlides, Michael; ORCID: https://orcid.org/0000-0001-9882-8874
+ Saffioti, Francesca; ORCID: https://orcid.org/0000-0001-7635-9931
+ Aveyard, Paul; ORCID: https://orcid.org/0000-0002-1802-4217
+Authors Full Name
+ Koutoukidis, Dimitrios A; Mozes, Ferenc E; Jebb, Susan A; Tomlinson, Jeremy W; Pavlides, Michael; Saffioti, Francesca; Huntriss, Rosemary; Aveyard, Paul; Cobbold, Jeremy F.
+Institution
+ Koutoukidis, Dimitrios A. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
+ Koutoukidis, Dimitrios A. National Institute for Health and Care Research Oxford Biomedical Research Centre, Oxford, UK.
+ Mozes, Ferenc E. Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
+ Jebb, Susan A. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
+ Jebb, Susan A. National Institute for Health and Care Research Oxford Biomedical Research Centre, Oxford, UK.
+ Tomlinson, Jeremy W. National Institute for Health and Care Research Oxford Biomedical Research Centre, Oxford, UK.
+ Tomlinson, Jeremy W. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
+ Pavlides, Michael. Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
+ Pavlides, Michael. Department of Gastroenterology and Hepatology, John Radcliffe Hospital, Oxford University Hospitals National Health Service Foundation Trust, Oxford, UK.
+ Saffioti, Francesca. Department of Gastroenterology and Hepatology, John Radcliffe Hospital, Oxford University Hospitals National Health Service Foundation Trust, Oxford, UK.
+ Huntriss, Rosemary. Oviva, London, UK.
+ Aveyard, Paul. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
+ Aveyard, Paul. National Institute for Health and Care Research Oxford Biomedical Research Centre, Oxford, UK.
+ Cobbold, Jeremy F. National Institute for Health and Care Research Oxford Biomedical Research Centre, Oxford, UK.
+ Cobbold, Jeremy F. Department of Gastroenterology and Hepatology, John Radcliffe Hospital, Oxford University Hospitals National Health Service Foundation Trust, Oxford, UK.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adult
+ Humans
+ Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease
+ Liver/dg [Diagnostic Imaging]
+ Liver/pa [Pathology]
+ Magnetic Resonance Imaging/mt [Methods]
+ Patient Acuity
+ Biomarkers
+ Obesity/pa [Pathology]
+ Fibrosis
+ Liver Cirrhosis/pa [Pathology]
+Abstract
+ OBJECTIVE: Low-energy diets are used to treat obesity and diabetes, but there are fears that they may worsen liver disease in patients with nonalcoholic steatohepatitis (NASH) and significant-to-advanced fibrosis.
+
+ METHODS: In this 24-week single-arm trial, 16 adults with NASH, fibrosis, and obesity received one-to-one remote dietetic support to follow a low-energy (880 kcal/d) total diet replacement program for 12 weeks and stepped food reintroduction for another 12 weeks. Liver disease severity was blindly evaluated (magnetic resonance imaging proton density fat fraction [MRI-PDFF], iron-corrected T1 [cT1], liver stiffness on magnetic resonance elastography [MRE], and liver stiffness on vibration-controlled transient elastography [VCTE]). Safety signals included liver biochemical markers and adverse events.
+
+ RESULTS: A total of 14 participants (87.5%) completed the intervention. Weight loss was 15% (95% CI: 11.2%-18.6%) at 24 weeks. Compared with baseline, MRI-PDFF reduced by 13.1% (95% CI: 8.9%-16.7%), cT1 by 159 milliseconds (95% CI: 108-216.5), MRE liver stiffness by 0.4 kPa (95% CI: 0.1-0.8), and VCTE liver stiffness by 3.9 kPa (95% CI: 2.6-7.2) at 24 weeks. The proportions with clinically relevant reductions in MRI-PDFF (>=30%), cT1 (>=88 milliseconds), MRE liver stiffness (>=19%), and VCTE liver stiffness (>=19%) were 93%, 77%, 57%, and 93%, respectively. Liver biochemical markers improved. There were no serious intervention-related adverse events.
+
+ CONCLUSIONS: The intervention demonstrates high adherence, favorable safety profile, and promising efficacy as a treatment for NASH. Copyright © 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1002%2foby.23793
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Koutoukidis&issn=1930-7381&title=Obesity&atitle=A+low-energy+total+diet+replacement+program+demonstrates+a+favorable+safety+profile+and+improves+liver+disease+severity+in+nonalcoholic+steatohepatitis.&volume=31&issue=7&spage=1767&epage=1778&date=2023&doi=10.1002%2Foby.23793&pmid=37368513&sid=OVID:medline
+
+<158>
+Unique Identifier
+ 38034020
+Title
+ Clinical characterization and proteomic profiling of lean nonalcoholic fatty liver disease.
+Source
+ Frontiers in Endocrinology. 14:1171397, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jiang Y; Zhuang X; Zhang J; Li M; Du S; Tian J; Yuan Y; Ji G; Hu C
+Authors Full Name
+ Jiang, Yuanye; Zhuang, Xiaoyu; Zhang, Jiaqi; Li, Meng; Du, Shengnan; Tian, Jiyun; Yuan, Yifu; Ji, Guang; Hu, Cheng.
+Institution
+ Jiang, Yuanye. Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+ Zhuang, Xiaoyu. Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+ Zhang, Jiaqi. Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+ Li, Meng. Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+ Du, Shengnan. Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+ Tian, Jiyun. Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+ Yuan, Yifu. Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+ Ji, Guang. Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+ Hu, Cheng. Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Overweight/co [Complications]
+ Proteomics
+ Obesity/co [Complications]
+ Biomarkers
+Keyword Heading
+ biomarker
+ lipid metabolism
+ mass spectrometry
+ nonalcoholic fatty liver disease
+ proteomic
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction: Obesity has been historically associated with nonalcoholic fatty liver disease (NAFLD), but it can also occur in lean individuals. However, limited data is available on this special group. To investigate the clinical and proteomic characteristics of lean subjects with NAFLD, and to identify potential clinical variables and plasma proteins for diagnosing NAFLD in lean individuals, we collected clinical data from a large cohort of 2,236 subjects.
+
+ Methods: Diagnosis of NAFLD relied on detecting pronounced hepatic steatosis through abdominal ultrasonography. Participants were categorized into four groups based on body mass index: overweight NAFLD, overweight control, lean NAFLD, and lean control. Plasma proteomic profiling was performed on samples from 20 subjects in each group. The lean NAFLD group was compared to both lean healthy and obese NAFLD groups across all data.
+
+ Results and discussion: The results indicated that the lean NAFLD group exhibited intermediate metabolic profiles, falling between those of the lean healthy and overweight NAFLD groups. Proteomic profiling of plasma in lean subjects with or without NAFLD revealed 45 statistically significant changes in proteins, of which 37 showed high diagnostic value (AUC > 0.7) for lean NAFLD. These potential biomarkers primarily involved lipid metabolism, the immune and complement systems, and platelet degranulation. Furthermore, AFM, GSN, CFH, HGFAC, MMP2, and MMP9 have been previously associated with NAFLD or NAFLD-related factors such as liver damage, insulin resistance, metabolic syndromes, and extracellular homeostasis. Overall, lean individuals with NAFLD exhibit distinct clinical profiles compared to overweight individuals with NAFLD. Despite having worse metabolic profiles than their healthy counterparts, lean NAFLD patients generally experience milder systemic metabolic disturbances compared to obese NAFLD patients. Additionally, the plasma proteomic profile is significantly altered in lean NAFLD, highlighting the potential of differentially expressed proteins as valuable biomarkers or therapeutic targets for diagnosing and treating NAFLD in this population. Copyright © 2023 Jiang, Zhuang, Zhang, Li, Du, Tian, Yuan, Ji and Hu.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3389%2ffendo.2023.1171397
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jiang&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Clinical+characterization+and+proteomic+profiling+of+lean+nonalcoholic+fatty+liver+disease.&volume=14&issue=&spage=1171397&epage=&date=2023&doi=10.3389%2Ffendo.2023.1171397&pmid=38034020&sid=OVID:medline
+
+<159>
+Unique Identifier
+ 37792298
+Title
+ Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers.
+Source
+ American Journal of Physiology - Endocrinology & Metabolism. 325(5):E562-E580, 2023 11 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hruska P; Kucera J; Kuruczova D; Buzga M; Pekar M; Holeczy P; Potesil D; Zdrahal Z; Bienertova-Vasku J
+Author NameID
+ Hruska, Pavel; ORCID: https://orcid.org/0000-0003-0705-854X
+Authors Full Name
+ Hruska, Pavel; Kucera, Jan; Kuruczova, Daniela; Buzga, Marek; Pekar, Matej; Holeczy, Pavol; Potesil, David; Zdrahal, Zbynek; Bienertova-Vasku, Julie.
+Institution
+ Hruska, Pavel. Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
+ Hruska, Pavel. Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
+ Kucera, Jan. RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic.
+ Kucera, Jan. Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czech Republic.
+ Kuruczova, Daniela. RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic.
+ Buzga, Marek. Department of Laboratory Medicine, University hospital Ostrava, Ostrava, Czech Republic.
+ Buzga, Marek. Department of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
+ Pekar, Matej. Vascular and Miniinvasive Surgery Center, Hospital AGEL Trinec-Podlesi, Trinec, Czech Republic.
+ Pekar, Matej. Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
+ Holeczy, Pavol. Department of Surgery, Vitkovice Hospital, Ostrava, Czech Republic.
+ Holeczy, Pavol. Department of Surgical Disciplines, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
+ Potesil, David. Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
+ Zdrahal, Zbynek. Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
+ Bienertova-Vasku, Julie. Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
+ Bienertova-Vasku, Julie. RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic.
+ Bienertova-Vasku, Julie. Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czech Republic.
+MeSH Subject Headings
+ Male
+ Female
+ Humans
+ Obesity, Morbid/me [Metabolism]
+ *Obesity, Morbid
+ *Insulin Resistance
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Cross-Sectional Studies
+ Proteomics
+ Obesity/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Subcutaneous Fat/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Proteins/me [Metabolism]
+ Intra-Abdominal Fat/me [Metabolism]
+Keyword Heading
+ obesity
+ proteomics
+ subcutaneous adipose tissue
+ type 2 diabetes
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In this study, we aimed to comprehensively characterize the proteomic landscapes of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in patients with severe obesity, to establish their associations with clinical characteristics, and to identify potential serum protein biomarkers indicative of tissue-specific alterations or metabolic states. We conducted a cross-sectional analysis of 32 patients with severe obesity (16 males and 16 females) of Central European descent who underwent bariatric surgery. Clinical parameters and body composition were assessed using dual-energy X-ray absorptiometry (DXA) and bioelectrical impedance, with 15 patients diagnosed with type 2 diabetes (T2D) and 17 with hypertension. Paired SAT and VAT samples, along with serum samples, were subjected to state-of-the-art proteomics liquid chromatography-mass spectrometry (LC-MS). Our analysis identified 7,284 proteins across SAT and VAT, with 1,249 differentially expressed proteins between the tissues and 1,206 proteins identified in serum. Correlation analyses between differential protein expression and clinical traits suggest a significant role of SAT in the pathogenesis of obesity and related metabolic complications. Specifically, the SAT proteomic profile revealed marked alterations in metabolic pathways and processes contributing to tissue fibrosis and inflammation. Although we do not establish a definitive causal relationship, it appears that VAT might respond to SAT metabolic dysfunction by potentially enhancing mitochondrial activity and expanding its capacity. However, when this adaptive response is exceeded, it could possibly contribute to insulin resistance (IR) and in some cases, it may be associated with the progression to T2D. Our findings provide critical insights into the molecular foundations of SAT and VAT in obesity and may inform the development of targeted therapeutic strategies. NEW & NOTEWORTHY This study provides insights into distinct proteomic profiles of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and serum in patients with severe obesity and their associations with clinical traits and body composition. It underscores SAT's crucial role in obesity development and related complications, such as insulin resistance (IR) and type 2 diabetes (T2D). Our findings emphasize the importance of understanding the SAT and VAT balance in energy homeostasis, proteostasis, and the potential role of SAT capacity in the development of metabolic disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1152%2fajpendo.00153.2023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hruska&issn=0193-1849&title=American+Journal+of+Physiology+-+Endocrinology+%26+Metabolism&atitle=Unraveling+adipose+tissue+proteomic+landscapes+in+severe+obesity%3A+insights+into+metabolic+complications+and+potential+biomarkers.&volume=325&issue=5&spage=E562&epage=E580&date=2023&doi=10.1152%2Fajpendo.00153.2023&pmid=37792298&sid=OVID:medline
+
+<160>
+Unique Identifier
+ 37918406
+Title
+ Identification and multicentric validation of soluble CDCP1 as a robust serological biomarker for risk stratification of NASH in obese Chinese.
+Source
+ Cell Reports Medicine. 4(11):101257, 2023 11 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jia X; Song E; Liu Y; Chen J; Wan P; Hu Y; Ye D; Chakrabarti S; Mahajan H; George J; Yan S; Yu Y; Zhang G; Wang Y; Yang W; Wu L; Hua S; Lee CH; Li H; Jiang X; Lam KSL; Wang C; Xu A
+Authors Full Name
+ Jia, Xi; Song, Erfei; Liu, Yan; Chen, Jiarui; Wan, Pei; Hu, Yue; Ye, Dewei; Chakrabarti, Subrata; Mahajan, Hema; George, Jacob; Yan, Sen; Yu, Yongtao; Zhang, Guanghui; Wang, Yong; Yang, Wah; Wu, Lihong; Hua, Shuang; Lee, Chi Ho; Li, Huixin; Jiang, Xue; Lam, Karen S L; Wang, Cunchuan; Xu, Aimin.
+Institution
+ Jia, Xi. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
+ Song, Erfei. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
+ Liu, Yan. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China.
+ Chen, Jiarui. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
+ Wan, Pei. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
+ Hu, Yue. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
+ Ye, Dewei. Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, China; Key Laboratory of Metabolic Phenotyping in Model Animals, Guangdong Pharmaceutical University, Guangzhou, China.
+ Chakrabarti, Subrata. Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.
+ Mahajan, Hema. Institute of Clinical Pathology and Medical Research, Pathology West, NSW Health Pathology, Sydney, NSW 2145, Australia; University of Western Sydney, Sydney, NSW, Australia.
+ George, Jacob. Storr Liver Centre, The Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia.
+ Yan, Sen. Dr. Everett Chalmers Hospital, Fredericton, NB, Canada.
+ Yu, Yongtao. Department of Gastrointestinal Surgery, General Hospital of Ningxia Medical University, Yinchuan, China.
+ Zhang, Guanghui. Department of Gastrointestinal Surgery, Zhengzhou Second Hospital, Zhengzhou, China.
+ Wang, Yong. Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
+ Yang, Wah. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
+ Wu, Lihong. Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China.
+ Hua, Shuang. Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, China.
+ Lee, Chi Ho. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
+ Li, Huixin. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
+ Jiang, Xue. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
+ Lam, Karen S L. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
+ Wang, Cunchuan. Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China. Electronic address: twcc@jnu.edu.cn.
+ Xu, Aimin. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China; Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China; Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China. Electronic address: amxu@hku.hk.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease
+ East Asian People
+ Obesity/di [Diagnosis]
+ Biomarkers
+ Risk Assessment
+ Antigens, Neoplasm
+ Cell Adhesion Molecules
+Keyword Heading
+ biomarkers
+ metabolic steatohepatitis
+ metabolic syndrome
+ non-alcoholic steatohepatitis
+ non-invasive diagnosis
+ personalized risk stratification
+ proteomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The definitive diagnosis of non-alcoholic steatohepatitis (NASH) currently relies on invasive and labor-intensive liver biopsy. Here, we identified soluble CUB domain-containing protein 1 (sCDCP1) as a top-ranked non-invasive biomarker for NASH using Olink-based proteomics in 238 obese individuals with liver biopsies. Both the circulating concentration and hepatic mRNA abundance of sCDCP1 were significantly elevated in patients with NASH and correlated closely with each histological feature of NASH. In the pooled multicenter validation cohort, sCDCP1 as a standalone biomarker achieved an area under the receiver operating characteristic (AUROC) of 0.838 (95% confidence interval [CI] 0.789-0.887) for diagnosing NASH, which is better than those achieved with cytokeratin-18 and other non-invasive tests. Furthermore, the C-DAG model established by the combination of sCDCP1 with diabetes, aspartate aminotransferase (AST), and gender accurately rules in and rules out both NASH and fibrotic NASH (gray zones <20%). Thus, sCDCP1-based non-invasive tests can be potentially implemented for screening and early diagnosis of NASH and for ruling out low-risk individuals to avoid unnecessary liver biopsies. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CDCP1 protein, human). 0 (Antigens, Neoplasm). 0 (Cell Adhesion Molecules).
+Publication Type
+ Multicenter Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.xcrm.2023.101257
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jia&issn=2666-3791&title=Cell+Reports+Medicine&atitle=Identification+and+multicentric+validation+of+soluble+CDCP1+as+a+robust+serological+biomarker+for+risk+stratification+of+NASH+in+obese+Chinese.&volume=4&issue=11&spage=101257&epage=&date=2023&doi=10.1016%2Fj.xcrm.2023.101257&pmid=37918406&sid=OVID:medline
+
+<161>
+Unique Identifier
+ 37523800
+Title
+ Biomarkers of glucose homeostasis as mediators of the relationship of body mass index and waist circumference with COVID-19 outcomes among postmenopausal women: The Women's Health Initiative.
+Source
+ Clinical Nutrition. 42(9):1690-1700, 2023 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Beydoun HA; Ng TKS; Beydoun MA; Shadyab AH; Jung SY; Costanian C; Saquib N; Ikramuddin FS; Pan K; Zonderman AB; Manson JE
+Authors Full Name
+ Beydoun, Hind A; Ng, Ted K S; Beydoun, May A; Shadyab, Aladdin H; Jung, Su Yon; Costanian, Christy; Saquib, Nazmus; Ikramuddin, Farha S; Pan, Kathy; Zonderman, Alan B; Manson, JoAnn E.
+Institution
+ Beydoun, Hind A. Department of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, VA, USA. Electronic address: hindb2020@gmail.com.
+ Ng, Ted K S. Department of Internal Medicine & Rush Institute of Healthy Aging, Rush University Medical Center, Chicago, IL, USA.
+ Beydoun, May A. Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
+ Shadyab, Aladdin H. Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
+ Jung, Su Yon. Translational Sciences Section, Jonsson Comprehensive Cancer Center, School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
+ Costanian, Christy. Center for Global Child Health, The Hospital for Sick Children (SickKids), Toronto, ON, USA.
+ Saquib, Nazmus. College of Medicine, Sulaiman AlRajhi University, Al Bukairiyah, Kingdom of Saudi Arabia.
+ Ikramuddin, Farha S. Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, USA.
+ Pan, Kathy. School of Medicine, University of California San Diego, San Diego, CA, USA.
+ Zonderman, Alan B. Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
+ Manson, JoAnn E. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+MeSH Subject Headings
+ Humans
+ Female
+ Middle Aged
+ Waist Circumference/ph [Physiology]
+ *Insulin Resistance
+ Body Mass Index
+ Blood Glucose/an [Analysis]
+ Postmenopause
+ *COVID-19
+ Glucose
+ Insulin
+ Women's Health
+ Biomarkers
+ Obesity
+ Homeostasis
+ Triglycerides
+ Risk Factors
+Keyword Heading
+ Coronavirus
+ Insulin resistance
+ Menopause
+ Obesity
+ Triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: Systematic reviews, meta-analyses and Mendelian randomization studies suggest that cardiometabolic diseases may be associated with COVID-19 risk and prognosis, with evidence implicating insulin resistance (IR) as a common biological mechanism. As driving factors for IR, we examined body mass index (BMI) and waist circumference (WC) among postmenopausal women in association with COVID-19 outcomes (positivity and hospitalization), and the role of glucose homeostasis as a mediator of this relationship.
+
+ METHODS: Associations of BMI and WC at baseline (1993-1998) with COVID-19 outcomes collected at Survey 1 (June-December, 2020) and/or Survey 2 (September-December, 2021) were evaluated among 42,770 Women's Health Initiative (WHI) participants (baseline age: 59.36 years) of whom 16,526 self-reported having taken >=1 COVID-19 test, with 1242 reporting >=1 positive COVID-19 test and 362 reporting >=1 COVID-19 hospitalization. We applied logistic regression and causal mediation analyses to sub-samples with available fasting biomarkers of glucose homeostasis (glucose, insulin, Homeostatic Model Assessment for Insulin Resistance, Homeostasis Model Assessment for beta-cell function, Quantitative Insulin-sensitivity Check Index, Triglyceride-Glucose index (TyG)) at baseline, whereby 57 of 759 reported COVID-19 test positivity and 23 of 1896 reported COVID-19 hospitalization.
+
+ RESULTS: In fully adjusted models, higher BMI, WC and TyG were associated with COVID-19 test positivity and hospitalization. Glucose concentrations mediated associations of BMI and WC with COVID-19 positivity, whereas TyG mediated BMI and WC's associations with COVID-19 hospitalization.
+
+ CONCLUSIONS: Obesity and central obesity markers collected an average of 24 years prior were associated with COVID-19 outcomes among postmenopausal women. Glucose concentration and TyG partly mediated these associations. Copyright Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Blood Glucose). IY9XDZ35W2 (Glucose). 0 (Insulin). 0 (Biomarkers). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.clnu.2023.07.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Beydoun&issn=0261-5614&title=Clinical+Nutrition&atitle=Biomarkers+of+glucose+homeostasis+as+mediators+of+the+relationship+of+body+mass+index+and+waist+circumference+with+COVID-19+outcomes+among+postmenopausal+women%3A+The+Women%27s+Health+Initiative.&volume=42&issue=9&spage=1690&epage=1700&date=2023&doi=10.1016%2Fj.clnu.2023.07.004&pmid=37523800&sid=OVID:medline
+
+<162>
+Unique Identifier
+ 37734587
+Title
+ Accumbens connectivity during deep-brain stimulation differentiates loss of control from physiologic behavioral states.
+Source
+ Brain Stimulation. 16(5):1384-1391, 2023 Sep-Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rolle CE; Ng GY; Nho YH; Barbosa DAN; Shivacharan RS; Gold JI; Bassett DS; Halpern CH; Buch V
+Authors Full Name
+ Rolle, Camarin E; Ng, Grace Y; Nho, Young-Hoon; Barbosa, Daniel A N; Shivacharan, Rajat S; Gold, Joshua I; Bassett, Dani S; Halpern, Casey H; Buch, Vivek.
+Institution
+ Rolle, Camarin E. Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Pennsylvania Hospital, Spruce Building 3rd Floor, 801 Spruce Street, Philadelphia, PA 19107, USA; Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, 3900 Woodland Ave, Philadelphia, PA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
+ Ng, Grace Y. Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Pennsylvania Hospital, Spruce Building 3rd Floor, 801 Spruce Street, Philadelphia, PA 19107, USA; Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, 3900 Woodland Ave, Philadelphia, PA, USA; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
+ Nho, Young-Hoon. Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Pennsylvania Hospital, Spruce Building 3rd Floor, 801 Spruce Street, Philadelphia, PA 19107, USA; Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, 3900 Woodland Ave, Philadelphia, PA, USA.
+ Barbosa, Daniel A N. Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Pennsylvania Hospital, Spruce Building 3rd Floor, 801 Spruce Street, Philadelphia, PA 19107, USA; Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, 3900 Woodland Ave, Philadelphia, PA, USA.
+ Shivacharan, Rajat S. Department of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road Office 245C, Stanford, CA 94304, USA.
+ Gold, Joshua I. Department of Neuroscience, University of Pennsylvania, 3700 Hamilton Walk, Richards D407, Philadelphia, PA 19104, USA.
+ Bassett, Dani S. Departments of Bioengineering, Physics and Astronomy, Electrical and Systems Engineering, Neurology, and Psychiatry, University of Pennsylvania, 210 S. 33rd St, Skirkanich Hall 240, Philadelphia, PA 19104, USA; Santa Fe Institute, 1399 Hyde Park Rd, Santa Fe, NM 87501, USA.
+ Halpern, Casey H. Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Pennsylvania Hospital, Spruce Building 3rd Floor, 801 Spruce Street, Philadelphia, PA 19107, USA; Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, 3900 Woodland Ave, Philadelphia, PA, USA.
+ Buch, Vivek. Department of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road Office 245C, Stanford, CA 94304, USA. Electronic address: vpbuch@stanford.edu.
+MeSH Subject Headings
+ Humans
+ *Bulimia
+ Feeding Behavior
+ Obesity
+ Nucleus Accumbens
+ Biomarkers
+Keyword Heading
+ Binge-eating
+ Deep brain stimulation
+ Loss of control
+ Nucleus accumbens
+ Obesity
+ Phase-locking value
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Loss of control (LOC) eating, the subjective sense that one cannot control what or how much one eats, characterizes binge-eating behaviors pervasive in obesity and related eating disorders. Closed-loop deep-brain stimulation (DBS) for binge eating should predict LOC and trigger an appropriately timed intervention.
+
+ OBJECTIVE/HYPOTHESIS: This study aimed to identify a sensitive and specific biomarker to detect LOC onset for DBS. We hypothesized that changes in phase-locking value (PLV) predict the onset of LOC-associated cravings and distinguish them from potential confounding states.
+
+ METHODS: Using DBS data recorded from the nucleus accumbens (NAc) of two patients with binge eating disorder (BED) and severe obesity, we compared PLV between inter- and intra-hemispheric NAc subregions for three behavioral conditions: craving (associated with LOC eating), hunger (not associated with LOC), and sleep.
+
+ RESULTS: In both patients, PLV in the high gamma frequency band was significantly higher for craving compared to sleep and significantly higher for hunger compared to craving. Maximum likelihood classifiers achieved accuracies above 88% when differentiating between the three conditions.
+
+ CONCLUSIONS: High-frequency inter- and intra-hemispheric PLV in the NAc is a promising biomarker for closed-loop DBS that differentiates LOC-associated cravings from physiologic states such as hunger and sleep. Future trials should assess PLV as a LOC biomarker across a larger cohort and a wider patient population transdiagnostically. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.brs.2023.09.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rolle&issn=1876-4754&title=Brain+Stimulation&atitle=Accumbens+connectivity+during+deep-brain+stimulation+differentiates+loss+of+control+from+physiologic+behavioral+states.&volume=16&issue=5&spage=1384&epage=1391&date=2023&doi=10.1016%2Fj.brs.2023.09.010&pmid=37734587&sid=OVID:medline
+
+<163>
+Unique Identifier
+ 38026824
+Title
+ The Interplay between Adipose Tissue Properties and Levels of NT-proBNP in People with HIV.
+Source
+ Journal of Obesity. 2023:6199388, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jacobsen MB; Reimer Jensen AM; Knudsen AD; Benfield T; Frikke-Schmidt R; Nordestgaard B; Afzal S; Kofoed KF; Gelpi M; Nielsen SD
+Author NameID
+ Nielsen, Susanne Dam; ORCID: https://orcid.org/0000-0001-6391-7455
+Authors Full Name
+ Jacobsen, Mads-Holger Bang; Reimer Jensen, Anne Marie; Knudsen, Andreas Dehlbaek; Benfield, Thomas; Frikke-Schmidt, Ruth; Nordestgaard, Borge; Afzal, Shoaib; Kofoed, Klaus Fuglsang; Gelpi, Marco; Nielsen, Susanne Dam.
+Institution
+ Jacobsen, Mads-Holger Bang. Viro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Reimer Jensen, Anne Marie. Viro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Reimer Jensen, Anne Marie. Department of Cardiology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
+ Knudsen, Andreas Dehlbaek. Viro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Knudsen, Andreas Dehlbaek. Department of Cardiology, The Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Benfield, Thomas. Center of Research & Disruption of Infectious Diseases, Amager and Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
+ Benfield, Thomas. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Frikke-Schmidt, Ruth. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Frikke-Schmidt, Ruth. Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Nordestgaard, Borge. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Nordestgaard, Borge. Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
+ Afzal, Shoaib. Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
+ Kofoed, Klaus Fuglsang. Department of Cardiology, The Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Kofoed, Klaus Fuglsang. Department of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Gelpi, Marco. Viro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Nielsen, Susanne Dam. Viro-Immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Nielsen, Susanne Dam. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+MeSH Subject Headings
+ Humans
+ Obesity, Abdominal/co [Complications]
+ *Obesity, Abdominal
+ Adiponectin
+ Obesity/co [Complications]
+ Adipose Tissue
+ HIV Infections/co [Complications]
+ *HIV Infections
+ Biomarkers
+Abstract
+ Objective: We aimed to assess the association between low N-terminal pro-brain natriuretic peptide (NT-proBNP) and body mass index (BMI), adipose tissue distribution, adiponectin, and HIV-specific risk factors among people with HIV (PWH).
+
+ Methods: We included 811 PWH with measurement of height, weight and waist circumference, blood samples analyzed for NT-proBNP, and visceral-(VAT) and subcutaneous (SAT) adipose tissue areas measured from CT-scans. Low concentrations of NT-proBNP were defined as concentrations below the limit of quantification (5.9 pmol/L). Associations were explored with multivariable logistic regression analyses adjusted for relevant confounders.
+
+ Results: We identified 471 (58%) individuals with low concentrations of NT-proBNP. Increasing BMI was associated with higher odds of low NT-proBNP (adjusted OR (aOR) 1.06 (95% CI: 1.01-1.11) per 1 kg/m2). Central obesity and large areas of VAT were associated with higher odds of low NT-proBNP (aOR 1.66 (1.16-2.36) and aOR 1.69 (1.09-2.62), respectively). Higher adiponectin was associated with lower odds of low NT-proBNP (aOR 0.86 (0.79-0.95) per 10% increase). No associations were found between low NT-proBNP and HIV-specific risk factors.
+
+ Conclusions: In PWH, low NT-proBNP is associated with an adverse adipose tissue profile with high BMI, central obesity, accumulation of VAT, and low adiponectin. Copyright © 2023 Mads-Holger Bang Jacobsen et al.
+Registry Number/Name of Substance
+ 0 (pro-brain natriuretic peptide (1-76)). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1155%2f2023%2f6199388
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jacobsen&issn=2090-0708&title=Journal+of+Obesity&atitle=The+Interplay+between+Adipose+Tissue+Properties+and+Levels+of+NT-proBNP+in+People+with+HIV.&volume=2023&issue=&spage=6199388&epage=&date=2023&doi=10.1155%2F2023%2F6199388&pmid=38026824&sid=OVID:medline
+
+<164>
+Unique Identifier
+ 38017390
+Title
+ Association between biomarkers of redox status and cytokines with different patterns of habitual physical activity in eutrophic and overweight/obese preschoolers: multivariate analysis of a cross-sectional study.
+Source
+ BMC Public Health. 23(1):2353, 2023 11 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Viegas AA; Santos T; Nobre JNP; Santos JMD; Silva Lage VKD; Fernandes AC; Peixoto MFD; Morais RLS; Sartorio A; Mendonca VA; Lacerda ACR
+Authors Full Name
+ Viegas, Angela Alves; Santos, Thiago; Nobre, Juliana Nogueira Pontes; Santos, Jousielle Marcia Dos; Silva Lage, Vanessa Kelly da; Fernandes, Amanda Cristina; Peixoto, Marco Fabricio Dias; Morais, Rosane Luzia De Souza; Sartorio, Alessandro; Mendonca, Vanessa Amaral; Lacerda, Ana Cristina Rodrigues.
+Institution
+ Viegas, Angela Alves. Multicenter Postgraduate Program in Physiological Sciences (PPGMCF), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Viegas, Angela Alves. Integrated Center for Research and Postgraduate Studies in Health (CIPq Saude), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Santos, Thiago. Postgraduate Program in Animal Biology (PPGBA), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Nobre, Juliana Nogueira Pontes. Multicenter Postgraduate Program in Physiological Sciences (PPGMCF), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Nobre, Juliana Nogueira Pontes. Integrated Center for Research and Postgraduate Studies in Health (CIPq Saude), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Santos, Jousielle Marcia Dos. Multicenter Postgraduate Program in Physiological Sciences (PPGMCF), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Santos, Jousielle Marcia Dos. Integrated Center for Research and Postgraduate Studies in Health (CIPq Saude), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Silva Lage, Vanessa Kelly da. Multicenter Postgraduate Program in Physiological Sciences (PPGMCF), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Silva Lage, Vanessa Kelly da. Integrated Center for Research and Postgraduate Studies in Health (CIPq Saude), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Fernandes, Amanda Cristina. Postgraduate Program in Rehabilitation and Functional Performance (PPGReab), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Peixoto, Marco Fabricio Dias. Multicenter Postgraduate Program in Physiological Sciences (PPGMCF), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Peixoto, Marco Fabricio Dias. Integrated Center for Research and Postgraduate Studies in Health (CIPq Saude), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Morais, Rosane Luzia De Souza. Postgraduate Program Health, Society and Environment (PPGSaSA), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Sartorio, Alessandro. Division of Auxology and Metabolic Diseases & Experimental Laboratory for Auxo-endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo-Verbania, Italy.
+ Mendonca, Vanessa Amaral. Multicenter Postgraduate Program in Physiological Sciences (PPGMCF), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Mendonca, Vanessa Amaral. Integrated Center for Research and Postgraduate Studies in Health (CIPq Saude), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Mendonca, Vanessa Amaral. Postgraduate Program in Rehabilitation and Functional Performance (PPGReab), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Lacerda, Ana Cristina Rodrigues. Multicenter Postgraduate Program in Physiological Sciences (PPGMCF), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil. lacerdaacr@gmail.com.
+ Lacerda, Ana Cristina Rodrigues. Integrated Center for Research and Postgraduate Studies in Health (CIPq Saude), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil. lacerdaacr@gmail.com.
+ Lacerda, Ana Cristina Rodrigues. Postgraduate Program in Rehabilitation and Functional Performance (PPGReab), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil. lacerdaacr@gmail.com.
+MeSH Subject Headings
+ Humans
+ *Overweight
+ *Leptin
+ Cross-Sectional Studies
+ Cytokines
+ Thiobarbituric Acid Reactive Substances
+ Body Mass Index
+ Obesity
+ Exercise
+ Oxidation-Reduction
+ Biomarkers
+ Multivariate Analysis
+ Superoxide Dismutase
+Keyword Heading
+ Accelerometry
+ Body composition
+ Childhood
+ Leptin
+ Oxidative stress
+ Triglycerides
+ sTNFRs
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although it is well known that obesity is frequently associated with reduced levels of habitual physical activity (HPA), which contributes to determining severe oxidative stress and inflammatory state, this association is however unknown in preschoolers so far. This study aimed to investigate the association between biomarkers of redox status and cytokines with different patterns of HPA according to the adiposity of preschoolers.
+
+ METHODS: A cross-sectional study was conducted in 50 preschoolers (25 overweight/obese, OW/OB and 25 eutrophic, EU), matched for age, sex, economic level, and maternal education. Total antioxidant capacity (TAC), superoxide dismutase (SOD) and catalase (CAT) activities, substances reactive to thiobarbituric acid (TBARS), soluble tumor necrosis factor receptors (sTNFRs), and leptin levels were evaluated. HPA levels were evaluated by accelerometry (ActiGraph GT9X accelerometer). Correlation, multiple linear regression, and partial least squares regression analysis were used to determine the association between redox status biomarkers and cytokines with different patterns of HPA (HPA level, bouts of moderate to vigorous physical activity [MVPA], and multivariate pattern of HPA) in EU and OW/OB preschoolers.
+
+ RESULTS: OW/OB preschoolers had lower CAT activity, higher levels of TAC, TBARS, and cytokines, and similar levels of HPA to EU preschoolers. In EU preschoolers, SOD activity exhibited a stronger negative association with moderate intensity ranges of HPA (R2 = 0.18), and negative correlation with sTNFRs (r = -0.40 to -0.46). TBARS had a stronger positive association with ranges of light intensity in the multivariate pattern of HPA (R2 = 0.10). In OW/OB preschoolers, the HPA multivariate associative pattern was predominantly from vigorous intensity ranges. Thus, SOD activity had a positive association with the multivariate pattern of HPA (R2 = 0.38) and MVPA bouts (beta [95% CI] = 0.457 [0.0026. 0.0576]). TAC had a negative association with the multivariate pattern of HPA (R2 = 0.38) and MVPA bouts (beta [95% CI] = -0.718 [-0.0025. -0.0003]). Additionally, leptin levels were lower in OW/OB preschoolers engaged in vigorous physical activity (VPA) (8000-9999 counts/min) for longer periods of time.
+
+ CONCLUSION: The results of this study indicate that OW/OB preschoolers have higher levels of oxidative stress biomarkers and pro-inflammatory cytokines compared to EU preschoolers. Moreover, VPA may exert antioxidative and anti-inflammatory effects in OW/OB preschoolers. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Leptin). 0 (Cytokines). 0 (Thiobarbituric Acid Reactive Substances). 0 (Biomarkers). EC 1-15-1-1 (Superoxide Dismutase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs12889-023-17295-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Viegas&issn=1471-2458&title=BMC+Public+Health&atitle=Association+between+biomarkers+of+redox+status+and+cytokines+with+different+patterns+of+habitual+physical+activity+in+eutrophic+and+overweight%2Fobese+preschoolers%3A+multivariate+analysis+of+a+cross-sectional+study.&volume=23&issue=1&spage=2353&epage=&date=2023&doi=10.1186%2Fs12889-023-17295-y&pmid=38017390&sid=OVID:medline
+
+<165>
+Unique Identifier
+ 37714902
+Title
+ Effects of obesity, and of weight loss following bariatric surgery, on methylation of DNA from the rectal mucosa and in cell-free DNA from blood.
+Source
+ International Journal of Obesity. 47(12):1278-1285, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ ElGendy K; Malcomson FC; Afshar S; Bradburn MD; Mathers JC
+Author NameID
+ ElGendy, Khalil; ORCID: http://orcid.org/0009-0000-0277-5385
+ Malcomson, Fiona C; ORCID: http://orcid.org/0000-0001-5072-7644
+ Afshar, Sorena; ORCID: http://orcid.org/0000-0002-4676-8117
+ Mathers, John C; ORCID: http://orcid.org/0000-0003-3406-3002
+Authors Full Name
+ ElGendy, Khalil; Malcomson, Fiona C; Afshar, Sorena; Bradburn, Michael D; Mathers, John C.
+Institution
+ ElGendy, Khalil. Human Nutrition Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England. Khalil.elgendy@nhs.net.
+ ElGendy, Khalil. Surgery Department, Northumbria NHS Foundation Trust, Newcastle upon Tyne, England. Khalil.elgendy@nhs.net.
+ Malcomson, Fiona C. Human Nutrition Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England.
+ Afshar, Sorena. Human Nutrition Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England.
+ Afshar, Sorena. Surgery Department, Northumbria NHS Foundation Trust, Newcastle upon Tyne, England.
+ Bradburn, Michael D. Surgery Department, Northumbria NHS Foundation Trust, Newcastle upon Tyne, England.
+ Mathers, John C. Human Nutrition Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England.
+MeSH Subject Headings
+ Humans
+ Rectum
+ *Cell-Free Nucleic Acids
+ Pro-Opiomelanocortin/ge [Genetics]
+ Obesity/ge [Genetics]
+ Obesity/su [Surgery]
+ Obesity/co [Complications]
+ Bariatric Surgery/mt [Methods]
+ *Bariatric Surgery
+ DNA Methylation/ge [Genetics]
+ Biomarkers
+ Inflammation/co [Complications]
+ Colorectal Neoplasms/ge [Genetics]
+ *Colorectal Neoplasms
+ DNA
+ Mucous Membrane
+ Weight Loss/ge [Genetics]
+Abstract
+ BACKGROUND: DNA methylation is an epigenetic mechanism through which environmental factors including nutrition and inflammation influence health. Obesity is a major modifiable risk factor for many common diseases including cardiovascular diseases and cancer. In particular, obesity-induced inflammation resulting from aberrantly-methylated inflammatory genes may drive risk of several non-communicable diseases including colorectal cancer (CRC). This study is the first to investigate the effects of weight loss induced by bariatric surgery (BS) on DNA methylation in the rectum and in cell-free DNA (cfDNA) from blood.
+
+ SUBJECTS AND METHODS: DNA methylation was quantified in rectal mucosal biopsies and cfDNA from serum of 28 participants with obesity before and 6 months after BS, as well as in 12 participants without obesity (control group) matched for age and sex from the Biomarkers Of Colorectal cancer After Bariatric Surgery (BOCABS) Study. DNA methylation of LEP, IL6, POMC, LINE1, MAPK7 and COX2 was quantified by pyrosequencing.
+
+ RESULTS: BMI decreased significantly from 41.8 kg/m2 pre-surgery to 32.3 kg/m2 at 6 months after BS. Compared with the control group, obesity was associated with lower LEP methylation in both the rectal mucosa and in cfDNA from serum. BS normalised LEP methylation in DNA from the rectal mucosa but not in cfDNA. BS decreased methylation of some CpG sites of LINE1 in the rectal mucosal DNA and in cfDNA to levels comparable with those in participants without obesity. Methylation of POMC in rectal mucosal DNA was normalised at 6 months after BS.
+
+ CONCLUSION: BS reversed LINE1, POMC and LEP methylation in the rectal mucosa of patients with obesity to levels similar to those in individuals without obesity. These findings support current evidence of effects of BS-induced weight loss on reversibility of DNA methylation in other tissues. The DNA methylation changes in the rectal mucosa shows promise as a biomarker for objective assessment of effects of weight loss interventions on risk of cancer and other diseases. Copyright © 2023. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Cell-Free Nucleic Acids). 66796-54-1 (Pro-Opiomelanocortin). 0 (Biomarkers). 9007-49-2 (DNA).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41366-023-01384-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=ElGendy&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Effects+of+obesity%2C+and+of+weight+loss+following+bariatric+surgery%2C+on+methylation+of+DNA+from+the+rectal+mucosa+and+in+cell-free+DNA+from+blood.&volume=47&issue=12&spage=1278&epage=1285&date=2023&doi=10.1038%2Fs41366-023-01384-4&pmid=37714902&sid=OVID:medline
+
+<166>
+Unique Identifier
+ 38044363
+Title
+ Identification of CXCL16 as a diagnostic biomarker for obesity and intervertebral disc degeneration based on machine learning.
+Source
+ Scientific Reports. 13(1):21316, 2023 12 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu J; Zhang J; Zhao X; Pan C; Liu Y; Luo S; Miao X; Wu T; Cheng X
+Authors Full Name
+ Liu, Jiahao; Zhang, Jian; Zhao, Xiaokun; Pan, Chongzhi; Liu, Yuchi; Luo, Shengzhong; Miao, Xinxin; Wu, Tianlong; Cheng, Xigao.
+Institution
+ Liu, Jiahao. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Liu, Jiahao. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China.
+ Zhang, Jian. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Zhang, Jian. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China.
+ Zhao, Xiaokun. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Zhao, Xiaokun. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China.
+ Pan, Chongzhi. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Pan, Chongzhi. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China.
+ Liu, Yuchi. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Liu, Yuchi. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China.
+ Luo, Shengzhong. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Luo, Shengzhong. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China.
+ Miao, Xinxin. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Miao, Xinxin. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China.
+ Miao, Xinxin. Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Wu, Tianlong. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Wu, Tianlong. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China.
+ Wu, Tianlong. Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, 330006, Jiangxi, China.
+ Cheng, Xigao. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China. xigaocheng@hotmail.com.
+ Cheng, Xigao. Institute of Orthopedics of Jiangxi Province, Nanchang, 330006, Jiangxi, China. xigaocheng@hotmail.com.
+ Cheng, Xigao. Institute of Minimally Invasive Orthopedics, Nanchang University, Nanchang, 330006, Jiangxi, China. xigaocheng@hotmail.com.
+MeSH Subject Headings
+ Humans
+ Intervertebral Disc Degeneration/di [Diagnosis]
+ Intervertebral Disc Degeneration/ge [Genetics]
+ Intervertebral Disc Degeneration/me [Metabolism]
+ *Intervertebral Disc Degeneration
+ Transcriptome
+ Risk Factors
+ Obesity/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Intervertebral Disc/me [Metabolism]
+ *Intervertebral Disc
+ Chemokine CXCL16/ge [Genetics]
+ Chemokine CXCL16/me [Metabolism]
+Abstract
+ Intervertebral disc degeneration (IDD) is the primary cause of neck and back pain. Obesity has been established as a significant risk factor for IDD. The objective of this study was to explore the molecular mechanisms affecting obesity and IDD by identifying the overlapping crosstalk genes associated with both conditions. The identification of specific diagnostic biomarkers for obesity and IDD would have crucial clinical implications. We obtained gene expression profiles of GSE70362 and GSE152991 from the Gene Expression Omnibus, followed by their analysis using two machine learning algorithms, least absolute shrinkage and selection operator and support vector machine-recursive feature elimination, which enabled the identification of C-X-C motif chemokine ligand 16 (CXCL16) as a shared diagnostic biomarker for obesity and IDD. Additionally, gene set variant analysis was used to explore the potential mechanism of CXCL16 in these diseases, and CXCL16 was found to affect IDD through its effect on fatty acid metabolism. Furthermore, correlation analysis between CXCL16 and immune cells demonstrated that CXCL16 negatively regulated T helper 17 cells to promote IDD. Finally, independent external datasets (GSE124272 and GSE59034) were used to verify the diagnostic efficacy of CXCL16. In conclusion, a common diagnostic biomarker for obesity and IDD, CXCL16, was identified using a machine learning algorithm. This study provides a new perspective for exploring the possible mechanisms by which obesity impacts the development of IDD. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CXCL16 protein, human). 0 (Chemokine CXCL16).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41598-023-48580-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=2045-2322&title=Scientific+Reports&atitle=Identification+of+CXCL16+as+a+diagnostic+biomarker+for+obesity+and+intervertebral+disc+degeneration+based+on+machine+learning.&volume=13&issue=1&spage=21316&epage=&date=2023&doi=10.1038%2Fs41598-023-48580-w&pmid=38044363&sid=OVID:medline
+
+<167>
+Unique Identifier
+ 37993481
+Title
+ Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population.
+Source
+ Scientific Reports. 13(1):20470, 2023 11 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zeng P; Cai X; Yu X; Gong L
+Authors Full Name
+ Zeng, Pei; Cai, Xiangsheng; Yu, Xiaozhou; Gong, Linjing.
+Institution
+ Zeng, Pei. Guangzhou Cadre Health Management Center, Guangzhou, 510000, China. 454300573@qq.com.
+ Cai, Xiangsheng. Guangzhou Cadre Health Management Center, Guangzhou, 510000, China.
+ Yu, Xiaozhou. School of Public Health, Sun Yat-Sen University, Guangzhou, 510000, China.
+ Gong, Linjing. Guangzhou Cadre Health Management Center, Guangzhou, 510000, China.
+MeSH Subject Headings
+ Humans
+ *Insulin Resistance
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Blood Glucose/me [Metabolism]
+ Biomarkers
+ Glucose/me [Metabolism]
+ Triglycerides
+ Obesity/co [Complications]
+ Cholesterol, HDL
+Abstract
+ Insulin resistance (IR) plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). IR markers are divided into two types: (1) insulin-based IR marker, homeostatic model assessment of IR (HOMA-IR); and (2) non-insulin-based IR markers, such as triglyceride-glucose (TyG) index, TyG index with body mass index (TyG-BMI), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-c), and metabolic score for IR (METS-IR). The non-insulin-based IR markers are often associated with lipids. The aim of this study was to analyse the association between IR markers and NAFLD in non-diabetic population. Baseline data of NAFLD and non-NAFLD groups were compared. Logistic regression was used to evaluate the relationship between five IR markers and NAFLD risk. The odds ratios (ORs) and 95% confidence intervals (CIs) of IR markers were calculated. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were used to evaluate the ability of different IR markers to detect NAFLD. Subgroup analyses were performed in obese and non-obese subgroups. This study found a positive correlation between NAFLD risk and elevation in five IR markers (HOMA-IR, TyG, TyG-BMI, TG/HDL-c, and METS-IR). In non-obese subjects, the AUC of TyG-BMI was larger than that of the other four IR markers to detect NAFLD. The AUC of HOMA-IR was larger than that of the other four IR markers to detect NAFLD in obese subjects. In non-diabetic population, the five IR markers are associated with the risk of NAFLD, including non-obese and obese NAFLD. TyG-BMI and HOMA-IR can be used to detect non-obese and obese NAFLD, respectively, with better detection ability compared with the other IR markers. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Blood Glucose). 0 (Biomarkers). IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Cholesterol, HDL).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41598-023-47269-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zeng&issn=2045-2322&title=Scientific+Reports&atitle=Markers+of+insulin+resistance+associated+with+non-alcoholic+fatty+liver+disease+in+non-diabetic+population.&volume=13&issue=1&spage=20470&epage=&date=2023&doi=10.1038%2Fs41598-023-47269-4&pmid=37993481&sid=OVID:medline
+
+<168>
+Unique Identifier
+ 37985679
+Title
+ Galectin-4 is associated with diabetes and obesity in a heart failure population.
+Source
+ Scientific Reports. 13(1):20285, 2023 11 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dieden A; Gudmundsson P; Korduner J; Molvin J; Zaghi A; Nezami Z; Bachus E; Holm H; Jujic A; Magnusson M
+Authors Full Name
+ Dieden, Anna; Gudmundsson, Petri; Korduner, Johan; Molvin, John; Zaghi, Amir; Nezami, Zainu; Bachus, Erasmus; Holm, Hannes; Jujic, Amra; Magnusson, Martin.
+Institution
+ Dieden, Anna. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. anna.dieden@mau.se.
+ Dieden, Anna. Department of Biomedical Science, Malmo University, Malmo, Sweden. anna.dieden@mau.se.
+ Dieden, Anna. Biofilms- Reseach Centre for Biointerfaces, Malmo University, Malmo, Sweden. anna.dieden@mau.se.
+ Gudmundsson, Petri. Department of Biomedical Science, Malmo University, Malmo, Sweden.
+ Gudmundsson, Petri. Biofilms- Reseach Centre for Biointerfaces, Malmo University, Malmo, Sweden.
+ Korduner, Johan. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Molvin, John. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Zaghi, Amir. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Nezami, Zainu. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Bachus, Erasmus. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Bachus, Erasmus. Late-Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
+ Holm, Hannes. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Jujic, Amra. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Magnusson, Martin. Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden.
+ Magnusson, Martin. Department of Cardiology, Skane University Hospital, Malmo, Sweden.
+ Magnusson, Martin. Hypertension in Africa Research Team (HART), North West University, Potchefstroom, South Africa.
+ Magnusson, Martin. Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
+MeSH Subject Headings
+ Humans
+ Female
+ Aged
+ Male
+ Galectin 4
+ Cross-Sectional Studies
+ Galectin 3
+ Heart Failure/ep [Epidemiology]
+ *Heart Failure
+ Biomarkers
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+Abstract
+ An association between high Galectin-4 (Gal-4) and prevalence of diabetes in subjects with heart failure (HF) has previously been reported. The purpose of this study was to confirm these findings, as well as to further investigate this association, in a Swedish HF population. In addition, a second aim was to explore Gal-4's association with obesity and biomarkers of metabolism and heart failure. Gal-4 was measured using a proximity extension array technique in 324 hospitalized HF patients within the Swedish HeArt and bRain failure investigation trial cohort. Obesity was defined as BMI >= 30. Multivariable logistic regression models were used to explore associations between Gal-4 and diabetes/obesity, and linear regression models were used to explore the associations between Gal-4 and biomarkers. A total of 309 participants (29.1% female; mean age 74.8 years) provided complete data for the analysis of associations between Gal-4 and diabetes. Additionally, for the analysis of heart failure phenotype, complete data was available for 230 subjects. Gal-4 was positively associated with prevalent diabetes (OR 2.60; CI 95% 1.56-4.32). In multivariable models, Gal-4 levels were significantly associated with obesity, but only for subjects with diabetes (OR 2.48; 1.09-5.62). Additionally, Gal-4 demonstrated a significant association with the incretin Glucose-dependent insulinotropic polypeptide (GIP), as well as with biomarkers of HF. In the stratified analyses, the association between Gal-4 and diabetes was prominent in patients with reduced ejection fraction (n = 160, OR 3.26; 95%CI 1.88-5.66), while it was not observed in those without (n = 70, 1.96 (0.75-5.10)). In this cross-sectional, observational study, higher Gal-4 levels in HF patients were associated with higher GIP levels. Further, increased levels of Gal-4 were associated with increased likelihood of diabetes, and obesity. This association was particularly pronounced in individuals with HF characterized by reduced ejection fraction. Additionally, Gal-4 levels were significantly elevated in heart failure patients with diabetes and obesity. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Galectin 4). 0 (Galectin 3). 0 (Biomarkers).
+Publication Type
+ Observational Study. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41598-023-47426-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dieden&issn=2045-2322&title=Scientific+Reports&atitle=Galectin-4+is+associated+with+diabetes+and+obesity+in+a+heart+failure+population.&volume=13&issue=1&spage=20285&epage=&date=2023&doi=10.1038%2Fs41598-023-47426-9&pmid=37985679&sid=OVID:medline
+
+<169>
+Unique Identifier
+ 37453961
+Title
+ Body mass index and implications for pediatric kidney health: a cross-sectional study with urinary biomarkers.
+Source
+ Pediatric Nephrology. 39(1):167-175, 2024 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gunasekara TDKSC; De Silva PMCS; Chandana EPS; Jayasinghe S; Herath C; Siribaddana S; Jayasundara N
+Author NameID
+ Gunasekara, T D K S C; ORCID: http://orcid.org/0000-0002-3095-6164
+ De Silva, P Mangala C S; ORCID: http://orcid.org/0000-0002-1927-6512
+ Chandana, E P S; ORCID: http://orcid.org/0000-0001-8113-7735
+ Jayasinghe, Sudheera; ORCID: http://orcid.org/0000-0003-3506-9908
+ Herath, Chula; ORCID: http://orcid.org/0000-0002-2901-4866
+ Siribaddana, Sisira; ORCID: http://orcid.org/0000-0001-5821-2557
+ Jayasundara, Nishad; ORCID: http://orcid.org/0000-0003-2485-6893
+Authors Full Name
+ Gunasekara, T D K S C; De Silva, P Mangala C S; Chandana, E P S; Jayasinghe, Sudheera; Herath, Chula; Siribaddana, Sisira; Jayasundara, Nishad.
+Institution
+ Gunasekara, T D K S C. Department of Zoology, Faculty of Science, University of Ruhuna, Matara, 81000, Sri Lanka.
+ De Silva, P Mangala C S. Department of Zoology, Faculty of Science, University of Ruhuna, Matara, 81000, Sri Lanka. chathura@zoo.ruh.ac.lk.
+ Chandana, E P S. Department of Biosystems Technology, Faculty of Technology, University of Ruhuna, Matara, 81000, Sri Lanka.
+ Jayasinghe, Sudheera. Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Galle, 80000, Sri Lanka.
+ Herath, Chula. Department of Nephrology, Sri Jayewardenepura General Hospital, Colombo, 10100, Sri Lanka.
+ Siribaddana, Sisira. Department of Medicine, Faculty of Medical & Allied Sciences, Rajarata University, Saliyapura, 50008, Sri Lanka.
+ Jayasundara, Nishad. Nicholas School of the Environment, Duke University, Durham, NC, 27708, USA.
+MeSH Subject Headings
+ Male
+ Female
+ Humans
+ Child
+ Lipocalin-2/ur [Urine]
+ Body Mass Index
+ Cross-Sectional Studies
+ Hepatitis A Virus Cellular Receptor 1
+ Kidney
+ Biomarkers/ur [Urine]
+ *Renal Insufficiency, Chronic
+ Obesity
+ Acute Kidney Injury/ur [Urine]
+ *Acute Kidney Injury
+Keyword Heading
+ Biomarkers
+ Body mass index
+ Kidney injury
+ Obesity pediatric
+ Sri Lanka
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Extremes of unhealthy body weight, particularly obesity, are known to increase the risk of chronic kidney diseases. However, the current knowledge of kidney health outcomes associated with unhealthy body weight remains incomprehensive, especially in pediatrics. Therefore, the present study aimed to evaluate body mass index (BMI) and its potential associations with kidney health in a selected subset of school students in Sri Lanka.
+
+ METHODS: This cross-sectional study was conducted among students of both sexes in the range of 11-18 years of age (N = 1078) in education zones with no reported cases of chronic kidney disease of uncertain etiology. Based on sex- and age-specific BMI percentiles (LMS method), the participants were classified into five BMI groups (severely thin, thin, healthy, overweight, and obese) for measurement of urinary biomarkers of kidney injury: kidney injury molecule (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and albumin creatinine ratio (ACR).
+
+ RESULTS: The median urinary levels of NGAL, ACR, and particularly KIM-1, which is a more sensitive indicator of kidney injury, showed no significant differences across the BMI strata. Importantly, moderate correlations of BMI with KIM-1 and NGAL were identified in severely thin girls.
+
+ CONCLUSIONS: According to the present study, these findings do not produce plausibly strong evidence to establish a potential association of BMI with altered kidney function in the studied pediatric communities. Particularly, a likelihood of abnormal kidney health outcomes associated with undernutrition is apparent in severely thin girls. However, in-depth studies are warranted to develop a comprehensive understanding of the associations of nutritional status with pediatric kidney health in Sri Lanka. A higher resolution version of the Graphical abstract is available as Supplementary information. Copyright © 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association.
+Registry Number/Name of Substance
+ 0 (Lipocalin-2). 0 (Hepatitis A Virus Cellular Receptor 1). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2024
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1007%2fs00467-023-06071-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gunasekara&issn=0931-041X&title=Pediatric+Nephrology&atitle=Body+mass+index+and+implications+for+pediatric+kidney+health%3A+a+cross-sectional+study+with+urinary+biomarkers.&volume=39&issue=1&spage=167&epage=175&date=2024&doi=10.1007%2Fs00467-023-06071-0&pmid=37453961&sid=OVID:medline
+
+<170>
+Unique Identifier
+ 37968684
+Title
+ The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial.
+Source
+ Journal of ovarian research. 16(1):216, 2023 Nov 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nikrad N; Farhangi MA; Fard Tabrizi FP; Vaezi M; Mahmoudpour A; Mesgari-Abbasi M
+Authors Full Name
+ Nikrad, Negin; Farhangi, Mahdieh Abbasalizad; Fard Tabrizi, Fatemeh Pourteymour; Vaezi, Maryam; Mahmoudpour, Ata; Mesgari-Abbasi, Mehran.
+Institution
+ Nikrad, Negin. Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Farhangi, Mahdieh Abbasalizad. Drug Applied Research Center, Tabriz University of Medical Sciences, Attar Neyshabouri, Daneshgah Blv, Tabriz, Iran. abbasalizad_m@yahoo.com.
+ Fard Tabrizi, Fatemeh Pourteymour. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Vaezi, Maryam. Fellowship Gynecology-Oncology, Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Vaezi, Maryam. Department of Obstetrics and Gynecology, Alzahra Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Mahmoudpour, Ata. Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Mesgari-Abbasi, Mehran. Drug Applied Research Center, Tabriz University of Medical Sciences, Attar Neyshabouri, Daneshgah Blv, Tabriz, Iran.
+MeSH Subject Headings
+ Female
+ Humans
+ Obesity
+ Polycystic Ovary Syndrome/dt [Drug Therapy]
+ *Polycystic Ovary Syndrome
+ Thylakoids
+ Brain-Derived Neurotrophic Factor
+ Spinacia oleracea
+ Caloric Restriction
+ Diet, Reducing
+ Lipopolysaccharides
+ Brain-Gut Axis
+ Biomarkers
+ Oxidative Stress
+ *Insulin Resistance
+Keyword Heading
+ Blood-brain barrier
+ Brain-derived neurotrophic factor
+ Brain-gut axis
+ Caloric restriction
+ Obesity
+ Oxidative stress
+ Polycystic ovary syndrome
+ Spinacia oleracea
+ Thylakoids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Women with polycystic ovary syndrome (PCOS) have higher intestinal mucosal permeability, leading to the lipopolysaccharide (LPS) leakage and endotoxemia. This, in turn, leads to oxidative stress (OS) and neuro-inflammation caused by the gut-brain axis, affecting the neurotrophic factors levels such as brain-derived neurotrophic factor (BDNF) and S100 calcium-binding protein B (S100 B) levels. In this study, it was hypothesized that the thylakoid membranes of spinach supplementation along with a hypocaloric diet may have improved the LPS levels, neurotrophic factors, and OS in PCOS patients.
+
+ METHODS: In this double-blind, randomized, placebo-controlled, and clinical trial, 48 women with obesity and diagnosed with PCOS based on Rotterdam criteria were randomly assigned to thylakoid (N = 21) and placebo groups (N = 23). A personalized hypocaloric diet with 500 calories less than the total energy expenditure was prescribed to all patients. The participants were daily supplemented with either a 5 g/day thylakoid-rich spinach extract or a placebo (5 g cornstarch) for 12 weeks along with a prescribed low-calorie diet. Anthropometric measurements and biochemical parameters were assessed at baseline and after the 12-week intervention.
+
+ RESULTS: A statistically significant decrease in the LPS levels (P < 0.001) and an increase in the BDNF levels (P < 0.001) were recorded for the participants receiving the oral thylakoid supplements and a low-calorie diet. Furthermore, significant decreases were observed in fasting blood glucose, insulin, homeostatic model of assessment for insulin resistance, free testosterone index, and follicle-stimulating hormone / luteinizing hormone ratio in both groups (P < 0.05). No significant differences were detected between the two groups regarding the changes in malondialdehyde, catalase, total antioxidant capacity, and S100B levels (P > 0.05).
+
+ CONCLUSIONS: In sum, the thylakoid membranes of spinach supplemented with a hypocaloric diet reduced the LPS levels, increased the BDNF levels, and improved the glycemic profile and sex-hormone levels; however, they had no effects on the OS markers levels after 12 weeks of intervention. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Brain-Derived Neurotrophic Factor). 0 (Lipopolysaccharides). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs13048-023-01288-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nikrad&issn=1757-2215&title=Journal+of+ovarian+research&atitle=The+effect+of+calorie-restriction+along+with+thylakoid+membranes+of+spinach+on+the+gut-brain+Axis+Pathway+and+oxidative+stress+biomarkers+in+obese+women+with+polycystic+ovary+syndrome%3A+a+Randomized%2C+Double-blind%2C+placebo-controlled+clinical+trial.&volume=16&issue=1&spage=216&epage=&date=2023&doi=10.1186%2Fs13048-023-01288-x&pmid=37968684&sid=OVID:medline
+
+<171>
+Unique Identifier
+ 37960355
+Title
+ Iron Levels and Markers of Inflammation in a Population of Adults with Severe Obesity, a Cross-Sectional Study.
+Source
+ Nutrients. 15(21), 2023 Nov 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Laudisio D; de Alteriis G; Vetrani C; Aprano S; Pugliese G; Zumbolo F; Colao A; Savastano S
+Author NameID
+ Laudisio, Daniela; ORCID: https://orcid.org/0000-0001-8177-0901
+ Vetrani, Claudia; ORCID: https://orcid.org/0000-0001-8335-5939
+ Savastano, Silvia; ORCID: https://orcid.org/0000-0002-3211-4307
+Authors Full Name
+ Laudisio, Daniela; de Alteriis, Giulia; Vetrani, Claudia; Aprano, Sara; Pugliese, Gabriella; Zumbolo, Francesca; Colao, Annamaria; Savastano, Silvia.
+Institution
+ Laudisio, Daniela. Department of Public Health, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Laudisio, Daniela. Centro Italiano per la Cura e il Benessere del Paziente con Obesita (C.I.B.O), Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ de Alteriis, Giulia. Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Vetrani, Claudia. Centro Italiano per la Cura e il Benessere del Paziente con Obesita (C.I.B.O), Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Vetrani, Claudia. Dipartimento di Scienze Umanistiche, Universita Telematica Pegaso, Via Porzio, Centro Isola F2, 80143 Napoli, Italy.
+ Aprano, Sara. Centro Italiano per la Cura e il Benessere del Paziente con Obesita (C.I.B.O), Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Pugliese, Gabriella. Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Zumbolo, Francesca. Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Colao, Annamaria. Centro Italiano per la Cura e il Benessere del Paziente con Obesita (C.I.B.O), Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Colao, Annamaria. Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Colao, Annamaria. Cattedra Unesco "Educazione Alla Salute e Allo Sviluppo Sostenibile", Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Savastano, Silvia. Centro Italiano per la Cura e il Benessere del Paziente con Obesita (C.I.B.O), Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Savastano, Silvia. Unita di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
+MeSH Subject Headings
+ Male
+ Female
+ Adult
+ Humans
+ Cross-Sectional Studies
+ *Obesity, Morbid
+ Obesity
+ Inflammation
+ C-Reactive Protein/an [Analysis]
+ Body Mass Index
+ Biomarkers
+ Waist Circumference
+ Fibrinogen/an [Analysis]
+Keyword Heading
+ c-reactive protein
+ low-grade chronic inflammation
+ obesity
+ serum iron levels
+ visceral obesity
+ waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Low-grade chronic inflammation linked to obesity can lead to alterations in biomarkers of iron status. The aim of this study was to investigate the primary determinant of serum iron levels among anthropometric measurements, body fat, and serum biomarkers of low-grade chronic inflammation in a group of adult individuals with severe obesity. We enrolled 114 individuals (84 females; 30 males) aged 40.96 +/- 12.54 years. Weight and body mass index (BMI) were 121.20 +/- 22.33 kg and 44.94 +/- 7.29 kg/m2, respectively. Some 30% of individuals had class-II obesity (BMI >= 35 <= 39.9 kg/m2) and 70% had class-III obesity (BMI >= 40 kg/m2). A weak, albeit significant, inverse correlation was found between serum iron levels and c-reactive protein (CRP) (r = -0.259, p = 0.008), fibrinogen (r = -0.261, p = 0.006), BMI (r = -0.186, p = 0.04), waist circumference (WC) (r = -0.265, p = 0.004), and fat mass % (r = -0.285, p = 0.003). With multiple linear regression analysis including CRP, fibrinogen, BMI, WC, and fat mass % as independent variables and serum iron levels as dependent variable, WC was entered in the first step (p = 0.001), which was followed by fat mass % (p = 0.047) and CRP (p = 0.047). Grouping the individuals according to the interquartile range of BMI, WC, and fat mass % (Q1-Q4), the lowest serum iron levels were found in Q4 groups of WC and fat mass % (p = 0.02), while no significant differences were found between groups in BMI quartiles. In conclusion, in our study, population serum iron levels were inversely associated with BMI, visceral obesity, fat mass %, CRP, and fibrinogen, but WC was the major negative predictor of serum iron level. These results supported the fact that visceral distribution of body fat, more than obesity per se, was associated with low serum iron levels in adult individuals with severe obesity.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Biomarkers). 9001-32-5 (Fibrinogen).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3390%2fnu15214702
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Laudisio&issn=2072-6643&title=Nutrients&atitle=Iron+Levels+and+Markers+of+Inflammation+in+a+Population+of+Adults+with+Severe+Obesity%2C+a+Cross-Sectional+Study.&volume=15&issue=21&spage=&epage=&date=2023&doi=10.3390%2Fnu15214702&pmid=37960355&sid=OVID:medline
+
+<172>
+Unique Identifier
+ 37948286
+Title
+ A Randomized Controlled Trial of Precision Nutrition Counseling for Service Members at Risk for Metabolic Syndrome.
+Source
+ Military Medicine. 188(Suppl 6):606-613, 2023 11 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ McCarthy MS; Colburn ZT; Yeung KY; Gillette LH; Hung LH; Elshaw E
+Author NameID
+ McCarthy, Mary S; ORCID: https://orcid.org/0000-0003-0230-9952
+Authors Full Name
+ McCarthy, Mary S; Colburn, Zachary T; Yeung, Ka Yee; Gillette, Laurel H; Hung, Ling-Hong; Elshaw, Evelyn.
+Institution
+ McCarthy, Mary S. Center for Nursing Science & Clinical Inquiry, Madigan Army Medical Center, Tacoma, WA 98431, USA.
+ Colburn, Zachary T. Center for Nursing Science & Clinical Inquiry, Madigan Army Medical Center, Tacoma, WA 98431, USA.
+ Yeung, Ka Yee. School of Engineering and Technology, University of Washington, Tacoma, WA 98402, USA.
+ Gillette, Laurel H. Center for Nursing Science & Clinical Inquiry, Madigan Army Medical Center, Tacoma, WA 98431, USA.
+ Hung, Ling-Hong. School of Engineering and Technology, University of Washington, Tacoma, WA 98402, USA.
+ Elshaw, Evelyn. The Geneva Foundation, Tacoma, WA 98402, USA.
+MeSH Subject Headings
+ Humans
+ Male
+ Adult
+ Female
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome
+ Prospective Studies
+ Obesity
+ Weight Loss
+ Cholesterol
+ Counseling
+ Biomarkers
+Abstract
+ INTRODUCTION: Metabolic syndrome (MetS) is a threat to the active component military as it impacts health, readiness, retention, and cost to the Military Health System. The most prevalent risk factors documented in service members' health records are high blood pressure (BP), low high-density lipoprotein cholesterol, and elevated triglycerides. Other risk factors include abdominal obesity and elevated fasting blood glucose. Precision nutrition counseling and wellness software applications have demonstrated positive results for weight management when coupled with high levels of participant engagement and motivation.
+
+ MATERIALS AND METHODS: In this prospective randomized controlled trial, trained registered dietitians conducted nutrition counseling using results of targeted sequencing, biomarkers, and expert recommendations to reduce the risk for MetS. Upon randomization, the treatment arm initiated six weekly sessions and the control arm received educational pamphlets. An eHealth application captured diet and physical activity. Anthropometrics and BP were measured at baseline, 6 weeks, and 12 weeks, and biomarkers were measured at baseline and 12 weeks. The primary outcome was a change in weight at 12 weeks. Statistical analysis included descriptive statistics and t-tests or analysis of variance with significance set at P < .05.
+
+ RESULTS: Overall, 138 subjects enrolled from November 2019 to February 2021 between two military bases; 107 completed the study. Demographics were as follows: 66% male, mean age 31 years, 66% married, and 49% Caucasian and non-Hispanic. Weight loss was not significant between groups or sites at 12 weeks. Overall, 27% of subjects met the diagnostic criteria for MetS on enrollment and 17.8% upon study completion. High deleterious variant prevalence was identified for genes with single-nucleotide polymorphisms linked to obesity (40%), cholesterol (38%), and BP (58%). Overall, 65% of subjects had low 25(OH)D upon enrollment; 45% remained insufficient at study completion. eHealth app had low adherence yet sufficient correlation with a valid reference.
+
+ CONCLUSIONS: Early signs of progress with weight loss at 6 weeks were not sustained at 12 weeks. DNA-based nutrition counseling was not efficacious for weight loss. Copyright Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2023. This work is written by (a) US Government employee(s) and is in the public domain in the US.
+Registry Number/Name of Substance
+ 97C5T2UQ7J (Cholesterol). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1093%2fmilmed%2fusad276
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=McCarthy&issn=0026-4075&title=Military+Medicine&atitle=A+Randomized+Controlled+Trial+of+Precision+Nutrition+Counseling+for+Service+Members+at+Risk+for+Metabolic+Syndrome.&volume=188&issue=6&spage=606&epage=613&date=2023&doi=10.1093%2Fmilmed%2Fusad276&pmid=37948286&sid=OVID:medline
+
+<173>
+Unique Identifier
+ 37945677
+Title
+ Network analysis identifies circulating miR-155 as predictive biomarker of type 2 diabetes mellitus development in obese patients: a pilot study.
+Source
+ Scientific Reports. 13(1):19496, 2023 11 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Catanzaro G; Conte F; Trocchianesi S; Splendiani E; Bimonte VM; Mocini E; Filardi T; Po A; Besharat ZM; Gentile MC; Paci P; Morano S; Migliaccio S; Ferretti E
+Authors Full Name
+ Catanzaro, Giuseppina; Conte, Federica; Trocchianesi, Sofia; Splendiani, Elena; Bimonte, Viviana Maria; Mocini, Edoardo; Filardi, Tiziana; Po, Agnese; Besharat, Zein Mersini; Gentile, Maria Cristina; Paci, Paola; Morano, Susanna; Migliaccio, Silvia; Ferretti, Elisabetta.
+Institution
+ Catanzaro, Giuseppina. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy.
+ Conte, Federica. Institute for Systems Analysis and Computer Science "A. Ruberti" (IASI), National Research Council (CNR), 00185, Rome, Italy.
+ Trocchianesi, Sofia. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy.
+ Splendiani, Elena. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy.
+ Bimonte, Viviana Maria. Department of Movement, Human and Health Sciences, University of Foro Italico, 00135, Rome, Italy.
+ Mocini, Edoardo. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy.
+ Filardi, Tiziana. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy.
+ Po, Agnese. Department of Molecular Medicine, Sapienza University, 00161, Rome, Italy.
+ Besharat, Zein Mersini. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy.
+ Gentile, Maria Cristina. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy.
+ Paci, Paola. Department of Computer, Control and Management Engineering, Sapienza University, 00161, Rome, Italy.
+ Morano, Susanna. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy.
+ Migliaccio, Silvia. Department of Movement, Human and Health Sciences, University of Foro Italico, 00135, Rome, Italy. silvia.migliaccio@uniroma4.it.
+ Ferretti, Elisabetta. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy. elisabetta.ferretti@uniroma1.it.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Diabetes Mellitus, Type 2
+ Pilot Projects
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ Biomarkers
+ *Circulating MicroRNA
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+Abstract
+ Obesity is the main risk factor for many non-communicable diseases. In clinical practice, unspecific markers are used for the determination of metabolic alterations and inflammation, without allowing the characterization of subjects at higher risk of complications. Circulating microRNAs represent an attractive approach for early screening to identify subjects affected by obesity more at risk of developing connected pathologies. The aim of this study was the identification of circulating free and extracellular vesicles (EVs)-embedded microRNAs able to identify obese patients at higher risk of type 2 diabetes (DM2). The expression data of circulating microRNAs derived from obese patients (OB), with DM2 (OBDM) and healthy donors were combined with clinical data, through network-based methodology implemented by weighted gene co-expression network analysis. The six circulating microRNAs overexpressed in OBDM patients were evaluated in a second group of patients, confirming the overexpression of miR-155-5p in OBDM patients. Interestingly, the combination of miR-155-5p with serum levels of IL-8, Leptin and RAGE was useful to identify OB patients most at risk of developing DM2. These results suggest that miR-155-5p is a potential circulating biomarker for DM2 and that the combination of this microRNA with other inflammatory markers in OB patients can predict the risk of developing DM2. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (MicroRNAs). 0 (Biomarkers). 0 (Circulating MicroRNA). 0 (MIRN155 microRNA, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41598-023-46516-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Catanzaro&issn=2045-2322&title=Scientific+Reports&atitle=Network+analysis+identifies+circulating+miR-155+as+predictive+biomarker+of+type+2+diabetes+mellitus+development+in+obese+patients%3A+a+pilot+study.&volume=13&issue=1&spage=19496&epage=&date=2023&doi=10.1038%2Fs41598-023-46516-y&pmid=37945677&sid=OVID:medline
+
+<174>
+Unique Identifier
+ 37943820
+Title
+ In Silico identification of novel phytochemicals that target SFRP4: An early biomarker of diabesity.
+Source
+ PLoS ONE [Electronic Resource]. 18(11):e0292155, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rehman A; Bukhari SA; Akhter N; Ijaz Hussain MA; Chauhdary Z
+Author NameID
+ Rehman, Asim; ORCID: https://orcid.org/0009-0005-4861-4161
+ Bukhari, Shazia Anwer; ORCID: https://orcid.org/0000-0001-9318-9364
+Authors Full Name
+ Rehman, Asim; Bukhari, Shazia Anwer; Akhter, Naheed; Ijaz Hussain, Muhammad Abdullah; Chauhdary, Zunera.
+Institution
+ Rehman, Asim. Department of Biochemistry, Government College University Faisalabad, Faisalabad, Pakistan.
+ Bukhari, Shazia Anwer. Department of Biochemistry, Government College University Faisalabad, Faisalabad, Pakistan.
+ Akhter, Naheed. Department of Biochemistry, Government College University Faisalabad, Faisalabad, Pakistan.
+ Ijaz Hussain, Muhammad Abdullah. Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan.
+ Chauhdary, Zunera. Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Molecular Docking Simulation
+ Insulin/me [Metabolism]
+ Biomarkers
+ Obesity/co [Complications]
+ Proto-Oncogene Proteins/me [Metabolism]
+Abstract
+ The simultaneous coexistence of complicated metabolic conditions like obesity and diabetes within an individual is known as diabesity. Obesity is the key factor for many chronic diseases, including insulin resistance and type 2 diabetes (T2D). Metabolic stress due to nutrient overload releases different inflammatory mediators. Secreted frizzled-related protein 4 (SFRP4) is also an inflammatory mediator that impairs insulin secretion. SFRP4 acts as an early biomarker for diabesity expressed with interleukin-1 beta (IL-1beta) in the adipose tissues that hinder the exocytosis of insulin-secreting granules from the pancreatic beta-cells and is a potential target for preserving beta-cell dysfunction and the diabesity treatment. The current study aimed to screen potential bioactive compounds targeting and inhibiting the diabesity-linked SFRP4 protein through an in silico approach. The three-dimensional (3D) structure of human SFRP4 was predicted through comparative modeling techniques and evaluated by various online bioinformatics tools. The molecular docking and MD simulation investigations were carried out against phytochemicals with anti-diabetic and anti-obesity properties to shortlist the best SFRP4 inhibitor. Hesperetin, Curcumin, Isorhamnetin, Embelin, Epicatechin, and Methyl Eugenol interacted strongly with SFRP4 by displaying zero RMSD and binding affinities of -6.5, -6.4, -6.3, -5.3, -6.3 and -5.8 kcal/mol respectively. Additionally, the root mean square fluctuation and root mean square deviation graphs from the MD simulation results demonstrated that hesperetin has good variations throughout the simulation period as compared to others. This dynamic stability and control behavior of hesperetin, when it interacts with SFRP4, shows that it has the potential to modulate the function and activity of the protein. Therefore, hesperetin is identified as an effective and top drug candidate through this analysis for preserving beta-cell function and treating diabesity by targeting SFRP4. The findings of this study could be useful in the design and development of diabesity drugs. Copyright: © 2023 Rehman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
+Registry Number/Name of Substance
+ 0 (Insulin). 0 (Biomarkers). 0 (SFRP4 protein, human). 0 (Proto-Oncogene Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1371%2fjournal.pone.0292155
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rehman&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=In+Silico+identification+of+novel+phytochemicals+that+target+SFRP4%3A+An+early+biomarker+of+diabesity.&volume=18&issue=11&spage=e0292155&epage=&date=2023&doi=10.1371%2Fjournal.pone.0292155&pmid=37943820&sid=OVID:medline
+
+<175>
+Unique Identifier
+ 37872771
+Title
+ B-cell-activating factor (BAFF) and platelet-activating factor (PAF) in pregnancies complicated by maternal obesity and diabetes: a preliminary study.
+Source
+ Journal of Maternal-Fetal & Neonatal Medicine. 36(2):2272010, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Neri C; Ciliberti A; Dessi DA; Airoldi C; Basello K; Costanzi A; Familiari A; Tersigni C; Cappelletti M; Speciani AF; Lanzone A
+Authors Full Name
+ Neri, Caterina; Ciliberti, Alessandra; Dessi, Davide Archelao; Airoldi, Chiara; Basello, Katia; Costanzi, Andrea; Familiari, Alessandra; Tersigni, Chiara; Cappelletti, Mattia; Speciani, Attilio Francesco; Lanzone, Antonio.
+Institution
+ Neri, Caterina. Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
+ Ciliberti, Alessandra. Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
+ Dessi, Davide Archelao. Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
+ Airoldi, Chiara. Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
+ Basello, Katia. GEK Lab, Milan, Italy.
+ Costanzi, Andrea. GEK Lab, Milan, Italy.
+ Familiari, Alessandra. Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
+ Tersigni, Chiara. Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
+ Cappelletti, Mattia. GEK Lab, Milan, Italy.
+ Speciani, Attilio Francesco. GEK Lab, Milan, Italy.
+ Lanzone, Antonio. Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanita Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
+MeSH Subject Headings
+ Female
+ Humans
+ Pregnancy
+ Biomarkers
+ *Diabetes, Gestational
+ Inflammation
+ Longitudinal Studies
+ Obesity/co [Complications]
+ *Obesity, Maternal
+ Platelet Activating Factor
+ Prospective Studies
+Keyword Heading
+ B-cell-activating factor
+ Maternal obesity
+ gestational diabetes
+ platelet-activating factor
+ proinflammatory cytokines
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: In pregnancies complicated by maternal obesity and diabetes, a disruption in inflammatory mediators occurs, resulting in endothelial microvascular dysfunction, oxidative stress, tissue damage, and maternal and feto-neonatal complications. To outline this proinflammatory status, an innovative approach is represented by the measurement of proinflammatory cytokines. Among these biomarkers, B-cell-activating factor (BAFF) and platelet-activating factor (PAF) play a key role in metabolic regulation, immune response to infections, tissue homeostasis, and "food-related inflammation." The aim of the present study is to investigate the blood expression of BAFF and PAF in a cohort of pregnant women affected by obesity and diabetes compared with a control group of healthy pregnant women.
+
+ METHODS: A prospective longitudinal cohort study has been conducted on pregnant women referred to Fondazione Policlinico Universitario Gemelli IRCCS in Rome. For each pregnant woman, a capillary sample was collected with a swab in three different consecutive evaluations carried out in the three trimesters of pregnancy.
+
+ RESULTS: A total of 77 pregnant women have been enrolled. No significant differences in BAFF and PAF levels were longitudinally observed between groups. Focusing on the exposed group, in the third trimester of pregnancy, both PAF and BAFF levels were lower than the basal time. Among the selected group of patients who developed Gestational Diabetes, only PAF values were longitudinally lower when compared to other groups. The multivariate analysis showed that BAFF levels were positively correlated with thyroid-stimulating hormone levels. No macrosomia, no shoulder dystocia, no major perineal lacerations at birth, and no intrauterine growth restriction were observed in the whole population.
+
+ CONCLUSIONS: This study supports the involvement of metabolic and proinflammatory biomarkers in the mechanisms related to pregnancy complications. Improving a good metabolic environment for obese and diabetic pregnant women could break the vicious cycle connecting inflammation, oxidative stress, and metabolic disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Platelet Activating Factor).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1080%2f14767058.2023.2272010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Neri&issn=1476-4954&title=Journal+of+Maternal-Fetal+%26+Neonatal+Medicine&atitle=B-cell-activating+factor+%28BAFF%29+and+platelet-activating+factor+%28PAF%29+in+pregnancies+complicated+by+maternal+obesity+and+diabetes%3A+a+preliminary+study.&volume=36&issue=2&spage=2272010&epage=&date=2023&doi=10.1080%2F14767058.2023.2272010&pmid=37872771&sid=OVID:medline
+
+<176>
+Unique Identifier
+ 37866956
+Title
+ [Association of Body Mass Index and Weight Gain With Obesity-Related Breast Cancer Risk Biomarkers in Adult Chinese Women]. [Chinese]
+Source
+ Sichuan da Xue Xue Bao. Yi Xue Ban/Journal of Sichuan University. Medical Science Edition. 54(5):978-984, 2023 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhou M; Hao Y; Fu P; Zhao X; Yan L; Li X; Li J
+Authors Full Name
+ Zhou, Min; Hao, Yu; Fu, Ping; Zhao, Xunying; Yan, Lanping; Li, Xingyue; Li, Jiayuan.
+Institution
+ Zhou, Min. Chengdu Shuangliu District Maternal and Child Health Care Hospital, Chengdu 610041, China.
+ Hao, Yu. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
+ Hao, Yu. Center for Education and Research in Public Health, West China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu 610041, China.
+ Fu, Ping. Chengdu Shuangliu District Maternal and Child Health Care Hospital, Chengdu 610041, China.
+ Zhao, Xunying. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
+ Zhao, Xunying. Center for Education and Research in Public Health, West China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu 610041, China.
+ Yan, Lanping. Chengdu Shuangliu District Maternal and Child Health Care Hospital, Chengdu 610041, China.
+ Li, Xingyue. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
+ Li, Xingyue. Center for Education and Research in Public Health, West China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu 610041, China.
+ Li, Jiayuan. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
+ Li, Jiayuan. Center for Education and Research in Public Health, West China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu 610041, China.
+MeSH Subject Headings
+ Humans
+ Adult
+ Female
+ Young Adult
+ Body Mass Index
+ Breast Neoplasms/et [Etiology]
+ *Breast Neoplasms
+ Adiponectin
+ Cross-Sectional Studies
+ East Asian People
+ Receptors, Leptin
+ Obesity/co [Complications]
+ Weight Gain
+ Risk Factors
+ Biomarkers
+ *Somatomedins
+ Body Weight
+Keyword Heading
+ Biomarker
+ Body mass index
+ Breast cancer
+ Weight gain in adulthood
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: To investigate the associatiojn of body mass index (BMI) at different stages of life and weight gain in adulthood with obesity-related breast cancer risk biomarkers and to provide evidence for formulating policies concerning the prevention and control of breast cancer.
+
+ Methods: A cross-sectional study was designed based on the follow-up cohort of southwest China community-based breast cancer screening of women. Using sequential sampling, eligible participants were enrolled from the cohort as the subjects of the study. Information on the basic risk factors was collected and the height, weight, and plasma biomarker levels were measured. Multiple linear regression model was applied to analyze the associations of early adulthood BMI (defined as the BMI of the participant at age 20), adulthood BMI (defined as the BMI measured at the time of enrollment), and weight gain in adulthood with the biomarkers. The concentrations of the biomarkers were incorporated in the model after log transformation.
+
+ Results: The average age of the 442 participants was 49 (45, 54) years old, the average early adulthood BMI and adulthood BMI were 21.47 (19.56, 23.11) and 24.10 (22.59, 25.97) kg/m 2, respectively, and the average weight gain in adulthood was 6.60 (2.00, 11.00) kg. Adulthood BMI was negatively associated with adiponectin level ( beta=-0.026, 95% CI: -0.045--0.008, P=0.006), and positively associated with C-reactive protein level ( beta=0.095, 95% CI: 0.054-0.137, P<0.001) and leptin receptor level ( beta=0.090, 95% CI: 0.063-0.117, P<0.001). No association was found between adulthood BMI and resistin levels or between adulthood BMI and insulin-like growth factor-binding protein-3 levels. BMI in early adulthood was found to be negatively associated with only insulin-like growth factor-binding protein-3 levels ( beta=-0.039, 95% CI: -0.068--0.010, P=0.009). Further analysis of adulthood weight gain after the age of 20 revealed that average annual weight gain in adulthood was negatively associated with adiponectin levels and positively associated with 4 other biomarkers. Furthermore, compared with those of women whose weight remained stable, the adiponectin level of women whose weight gain in adulthood exceeded 5.00 kg was much lower ( beta=-0.185, 95% CI: -0.320--0.049, P=0.008), while their insulin-like growth factor-binding protein-3 ( beta=0.389, 95% CI: 0.183-0.594, P<0.001) and leptin receptor ( beta=0.245, 95% CI: 0.048-0.442, P=0.015) levels were higher.
+
+ Conclusion: Weight gain in adulthood is strongly associated with the changes in obesity-related breast cancer risk biomarkers. Women should maintain a stable weight throughout adulthood and it is preferred that their weight gain should not exceed 5.00 kg. Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Receptors, Leptin). 0 (Biomarkers). 0 (Somatomedins).
+Publication Type
+ English Abstract. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.12182%2f20230960503
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhou&issn=1672-173X&title=Sichuan+da+Xue+Xue+Bao.+Yi+Xue+Ban%2FJournal+of+Sichuan+University.+Medical+Science+Edition&atitle=%5BAssociation+of+Body+Mass+Index+and+Weight+Gain+With+Obesity-Related+Breast+Cancer+Risk+Biomarkers+in+Adult+Chinese+Women%5D.&volume=54&issue=5&spage=978&epage=984&date=2023&doi=10.12182%2F20230960503&pmid=37866956&sid=OVID:medline
+
+<177>
+Unique Identifier
+ 37858097
+Title
+ Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized, double-blind, placebo-controlled clinical trial.
+Source
+ BMC Complementary Medicine and Therapies. 23(1):368, 2023 Oct 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baek HI; Ha KC; Park YK; Lee JH; Kim EJ; Ko HJ; Joo JC
+Authors Full Name
+ Baek, Hyang-Im; Ha, Ki-Chan; Park, Yu Kyung; Lee, Je Hyeon; Kim, Eun Joo; Ko, Hye-Jeong; Joo, Jong Cheon.
+Institution
+ Baek, Hyang-Im. Department of Food Science & Nutrition, Woosuk University, Wanju, 55338, Republic of Korea.
+ Baek, Hyang-Im. Healthcare Claims & Management Inc, Jeonju, 54858, Republic of Korea.
+ Ha, Ki-Chan. Healthcare Claims & Management Inc, Jeonju, 54858, Republic of Korea.
+ Park, Yu Kyung. Healthcare Claims & Management Inc, Jeonju, 54858, Republic of Korea.
+ Lee, Je Hyeon. Dyne Bio Inc, Sungnam, 13209, Republic of Korea.
+ Kim, Eun Joo. Dyne Bio Inc, Sungnam, 13209, Republic of Korea.
+ Ko, Hye-Jeong. Dyne Bio Inc, Sungnam, 13209, Republic of Korea.
+ Joo, Jong Cheon. Department of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University, Iksan, 54538, Republic of Korea. jcjoo2000@hanmail.net.
+MeSH Subject Headings
+ Male
+ Female
+ Humans
+ Overweight/dt [Drug Therapy]
+ *Overweight
+ Body Weight
+ Obesity/dt [Drug Therapy]
+ *Obesity
+ Oligosaccharides/tu [Therapeutic Use]
+ Biomarkers
+Keyword Heading
+ Body weight
+ Clinical trial
+ Neoagaro-oligosaccharides
+ Obesity
+ Overweight
+ Visceral fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: This trial aimed to evaluate the anti-obesity effects and safety of Neoagaro-oligosaccharides (NAOs) in humans in a 16 week, randomized, double-blind, placebo-controlled clinical trial.
+
+ METHODS: One hundred overweight or obese subjects with a body mass index of 23 to 34.9 kg/m2 and a percent body fat of > 25% for males or > 30% for females were enrolled. NAOs or placebo products were administered at 3 g (twice a day, four capsules once) each for 16 weeks. Efficacy and safety biomarkers were measured before and after intervention.
+
+ RESULTS: After 16 weeks of intervention, the group administered with NAOs had statistically significant decreases in visceral fat area and visceral-subcutaneous fat area ratio compared to the placebo group. The NAOs group suppressed the increase in weight and BMI compared to the placebo group, which was significant between groups. High-density lipoprotein- cholesterol was increased in the group administered with NAOs, which showed a significant trend compared to the placebo group. Clinical changes were not observed for any safety biomarkers.
+
+ CONCLUSIONS: These results suggest that NAOs have a beneficial effect on obesity. Thus, NAOs could be used as an anti-obesity supplement without side effects.
+
+ TRIAL REGISTRATION: cris.nih.go.kr: (KCT0006640, 07/10/2021). Copyright © 2023. BioMed Central Ltd., part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Oligosaccharides). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs12906-023-04206-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baek&issn=2662-7671&title=BMC+Complementary+Medicine+and+Therapies&atitle=Anti-obesity+effect+of+Neoagaro-oligosaccharides+with+overweight+and+obese+subjects%3A+a+16-week%2C+randomized%2C+double-blind%2C+placebo-controlled+clinical+trial.&volume=23&issue=1&spage=368&epage=&date=2023&doi=10.1186%2Fs12906-023-04206-2&pmid=37858097&sid=OVID:medline
+
+<178>
+Unique Identifier
+ 37836535
+Title
+ Epigenetic Biomarkers of Metabolic Responses to Lifestyle Interventions. [Review]
+Source
+ Nutrients. 15(19), 2023 Oct 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ramos-Lopez O
+Author NameID
+ Ramos-Lopez, Omar; ORCID: https://orcid.org/0000-0002-2505-1555
+Authors Full Name
+ Ramos-Lopez, Omar.
+Institution
+ Ramos-Lopez, Omar. Medicine and Psychology School, Autonomous University of Baja California, Tijuana 22390, Mexico.
+MeSH Subject Headings
+ Humans
+ *Epigenesis, Genetic
+ *DNA Methylation
+ Biomarkers
+ Obesity/ge [Genetics]
+ Life Style
+Keyword Heading
+ DNA methylation
+ biomarkers
+ epigenetics
+ histone modifications
+ metabolic alterations
+ miRNAs
+ precision nutrition
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Studies have examined the possible utility of epigenetic phenomena (DNA methylation changes, covalent histone modifications, and miRNA expression patterns) in predicting individual responses to different lifestyle programs. Nonetheless, most available evidence is focused on identifying epigenetic marks eventually associated with body composition and adiposity outcomes, whereas their roles in metabolic endings remain less explored. This document comprehensively reviewed the evidence regarding the use of epigenetic signatures as putative biomarkers of metabolic outcomes (glycemic, lipid, blood pressure, and inflammatory/oxidative stress features) in response to different lifestyle interventions in humans. Although more investigation is still necessary in order to translate this knowledge in clinical practice, these scientific insights are contributing to the design of advanced strategies for the precise management of cardiometabolic risk, gaining understanding on metabolic heterogeneity, allowing for the prediction of metabolic outcomes, and facilitating the design of epigenome-based nutritional strategies for a more customized approach for metabolic alterations treatment under the scope of precision nutrition.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3390%2fnu15194251
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ramos-Lopez&issn=2072-6643&title=Nutrients&atitle=Epigenetic+Biomarkers+of+Metabolic+Responses+to+Lifestyle+Interventions.&volume=15&issue=19&spage=&epage=&date=2023&doi=10.3390%2Fnu15194251&pmid=37836535&sid=OVID:medline
+
+<179>
+Unique Identifier
+ 37836527
+Title
+ Change in Urinary Inflammatory Biomarkers and Psychological Health with Gut Microbiome Modulation after Six Months of a Lifestyle Modification Program in Children.
+Source
+ Nutrients. 15(19), 2023 Oct 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Islam MS; Page-Hefley S; Hernandez AP; Whelchel L; Crasto C; Viator W; Money T; Awosile B; Howard N; Vasylyeva TL
+Author NameID
+ Whelchel, Luke; ORCID: https://orcid.org/0000-0003-0900-2646
+ Awosile, Babafela; ORCID: https://orcid.org/0000-0002-4779-6515
+Authors Full Name
+ Islam, Md Saimul; Page-Hefley, Shyanne; Hernandez, Anne P; Whelchel, Luke; Crasto, Chiquito; Viator, Whitney; Money, Treyce; Awosile, Babafela; Howard, Noel; Vasylyeva, Tetyana L.
+Institution
+ Islam, Md Saimul. Texas Tech University Health Sciences Center, Department of Pediatrics, Amarillo, TX 79121, USA.
+ Page-Hefley, Shyanne. Texas Tech University Health Sciences Center, Department of Pediatrics, Amarillo, TX 79121, USA.
+ Hernandez, Anne P. Private Psychologist, 101 SE 18th Ave, Amarillo, TX 79102, USA.
+ Whelchel, Luke. Texas Tech University Health Sciences Center, Department of Pediatrics, Amarillo, TX 79121, USA.
+ Crasto, Chiquito. Center for Biotechnology and Genomics, Texas Tech University, Canton & Main Experimental Sciences Building, Room 101, Lubbock, TX 79409, USA.
+ Viator, Whitney. Texas Tech University Health Sciences Center, Department of Pediatrics, Amarillo, TX 79121, USA.
+ Money, Treyce. Texas Tech University Health Sciences Center, Department of Pediatrics, Amarillo, TX 79121, USA.
+ Awosile, Babafela. Center for Biotechnology and Genomics, Texas Tech University School of Veterinary Medicine, Amarillo, TX 79106, USA.
+ Howard, Noel. Texas Tech University Health Sciences Center, Department of Pediatrics, Amarillo, TX 79121, USA.
+ Vasylyeva, Tetyana L. Texas Tech University Health Sciences Center, Department of Pediatrics, Amarillo, TX 79121, USA.
+MeSH Subject Headings
+ Adolescent
+ Humans
+ Child
+ Overweight/th [Therapy]
+ Overweight/mi [Microbiology]
+ *Overweight
+ Gastrointestinal Microbiome/ph [Physiology]
+ *Gastrointestinal Microbiome
+ Quality of Life
+ Mental Health
+ Obesity/mi [Microbiology]
+ Biomarkers
+ Life Style
+ Inflammation
+Keyword Heading
+ adolescents
+ gut-brain axis
+ inflammation
+ microbiome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Obesity is a metabolic disorder that negatively impacts the quality of life. Long-term methods such as exercise and low-fat diets can help regulate this health issue, but 93.3 million Americans continue to struggle. Our research investigates if lifestyle changes can affect urinary inflammation markers and psychological aspects through the modification of gut microbiome composition. Methods: Our study included 16 healthy controls with normal BMI as a comparison group and 22 overweight/obese (OW/OB) adolescents. We collected demographic, clinical, psychological, stool, and urine sample data at enrollment and six months after implementing lifestyle modifications. Bacterial genomic data and inflammatory markers in these samples were analyzed. Results: The lifestyle interventions were associated with decreased inflammation and enhanced mental health among overweight teens. We observed differences in bacterial community compositions between healthy participants and those who underwent treatment, including exercise and dietary habit adjustments, although there was no significant change in bacterial species richness. Mental health correlated with gut microbiota compositions without any demographic influences. The research also uncovered connections between inflammatory markers, psychological factors, and gut microbiota phyla through carbohydrate metabolism alterations. Conclusion: Our findings demonstrate that lifestyle modifications are associated with improved mental health and a reduction in inflammation in overweight adolescents by adjusting the gut microbiota composition.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3390%2fnu15194243
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Islam&issn=2072-6643&title=Nutrients&atitle=Change+in+Urinary+Inflammatory+Biomarkers+and+Psychological+Health+with+Gut+Microbiome+Modulation+after+Six+Months+of+a+Lifestyle+Modification+Program+in+Children.&volume=15&issue=19&spage=&epage=&date=2023&doi=10.3390%2Fnu15194243&pmid=37836527&sid=OVID:medline
+
+<180>
+Unique Identifier
+ 37798684
+Title
+ Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: a systematic review and meta-analysis.
+Source
+ BMC Oral Health. 23(1):717, 2023 10 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang Y; Jia R; Zhang Y; Sun X; Mei Y; Zou R; Niu L; Dong S
+Authors Full Name
+ Zhang, Yuwei; Jia, Ru; Zhang, Yifei; Sun, Xuefei; Mei, Yukun; Zou, Rui; Niu, Lin; Dong, Shaojie.
+Institution
+ Zhang, Yuwei. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Zhang, Yuwei. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi'an, 710004, Shaanxi Province, China.
+ Zhang, Yuwei. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Jia, Ru. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Jia, Ru. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi'an, 710004, Shaanxi Province, China.
+ Jia, Ru. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Zhang, Yifei. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Zhang, Yifei. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi'an, 710004, Shaanxi Province, China.
+ Zhang, Yifei. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Sun, Xuefei. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Sun, Xuefei. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi'an, 710004, Shaanxi Province, China.
+ Mei, Yukun. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Mei, Yukun. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi'an, 710004, Shaanxi Province, China.
+ Mei, Yukun. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
+ Zou, Rui. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China. rainy@xjtu.edu.cn.
+ Zou, Rui. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi'an, 710004, Shaanxi Province, China. rainy@xjtu.edu.cn.
+ Niu, Lin. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China. niulin@xjtu.edu.cn.
+ Niu, Lin. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi'an, 710004, Shaanxi Province, China. niulin@xjtu.edu.cn.
+ Niu, Lin. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China. niulin@xjtu.edu.cn.
+ Dong, Shaojie. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China. dongshaojie@xjtu.edu.cn.
+ Dong, Shaojie. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi'an, 710004, Shaanxi Province, China. dongshaojie@xjtu.edu.cn.
+ Dong, Shaojie. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China. dongshaojie@xjtu.edu.cn.
+MeSH Subject Headings
+ Humans
+ Cytokines/me [Metabolism]
+ *Cytokines
+ Adipokines/an [Analysis]
+ Adipokines/me [Metabolism]
+ Resistin
+ C-Reactive Protein/me [Metabolism]
+ Interleukin-6/me [Metabolism]
+ Chronic Periodontitis/th [Therapy]
+ *Chronic Periodontitis
+ Adiponectin
+ Prospective Studies
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Biomarkers/an [Analysis]
+ Tumor Necrosis Factor-alpha/me [Metabolism]
+ Gingival Crevicular Fluid/ch [Chemistry]
+ Retinol-Binding Proteins, Plasma/me [Metabolism]
+Keyword Heading
+ Adipocytokines
+ Cytokines
+ Inflammation
+ Non-surgical periodontal therapy
+ Obesity
+ Periodontitis
+ Systematic review
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The objective of this systematic review and meta-analysis was to evaluate the effects of non-surgical periodontal therapy (NSPT) on inflammatory-related cytokines/adipocytokines in periodontitis patients with or without obesity.
+
+ METHODS: We followed the preferred reporting items for systematic reviews and meta-analyses statement and registered the study (CRD42022375331) in the Prospective International Register of Systematic Reviews. We screened randomized-controlled trials and controlled clinical trials from six databases up to December 2022. Quality assessment was performed with RoB-2 and ROBINS-I tools for randomized trials and non-randomized trials, respectively. Meta-analysis was carried out using a random-effect model.
+
+ RESULTS: We included seventeen references in the systematic analysis, and sixteen in the meta-analysis. Baseline results of pro-inflammatory biomarkers, including serum interleukin (IL)-6, serum and gingival crevicular fluid (GCF), tumor necrosis factor (TNF)-a, serum C-reactive protein (CRP)/hs-CRP, and serum and GCF resistin, were higher in obesity subjects than in normal weight subjects. The effect of NSPT with respect to levels of cytokines/adipocytokines, including IL-6, TNF-a, CRP/hs-CRP, resistin, adiponectin, leptin and retinol binding protein 4 (RBP4), were then analyzed in the systematic and meta-analysis. After three months of NSPT, serum (MD = -0.54, CI = -0.62 - -0.46), and GCF (MD = -2.70, CI = -4.77 - -0.63) levels of IL-6, along with the serum RBP4 (MD = -0.39, CI = -0.68-0.10) decreased in periodontitis individuals with obesity. NSPT also improved GCF adiponectin levels after three months (MD = 2.37, CI = 0.29 - 4.45) in periodontitis individuals without obesity.
+
+ CONCLUSIONS: Obese status altered the baseline levels of cytokines/adipocytokines (serum IL-6, serum and GCF TNF-a, serum CRP/hs-CRP, and serum and GCF resistin). Then NSPT can shift the levels of specific pro-inflammatory mediators and anti-inflammatory mediators in biological fluids, both in obesity and non-obesity individuals. NSPT can reduce serum and GCF IL-6 levels together with serum RBP4 level in individuals with obesity after 3 months, besides, there is no sufficient evidence to prove that obese patients have a statistically significant decrease in the levels of other cytokines compared to patients with normal weight. NSPT can also increase GCF adiponectin level in normal weight individuals after 3 months. Our findings imply the potential ideal follow-up intervals and sensitive biomarkers for clinical bioanalysis in personalized decision-making of effect of NSPT due to patients' BMI value. Copyright © 2023. BioMed Central Ltd., part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Cytokines). 0 (Adipokines). 0 (Resistin). 9007-41-4 (C-Reactive Protein). 0 (Interleukin-6). 0 (Adiponectin). 0 (Biomarkers). 0 (Tumor Necrosis Factor-alpha). 0 (RBP4 protein, human). 0 (Retinol-Binding Proteins, Plasma).
+Publication Type
+ Meta-Analysis. Systematic Review. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs12903-023-03383-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1472-6831&title=BMC+Oral+Health&atitle=Effect+of+non-surgical+periodontal+treatment+on+cytokines%2Fadipocytokines+levels+among+periodontitis+patients+with+or+without+obesity%3A+a+systematic+review+and+meta-analysis.&volume=23&issue=1&spage=717&epage=&date=2023&doi=10.1186%2Fs12903-023-03383-3&pmid=37798684&sid=OVID:medline
+
+<181>
+Unique Identifier
+ 37794463
+Title
+ Ceramide d18:1/24:1 as a potential biomarker to differentiate obesity subtypes with unfavorable health outcomes.
+Source
+ Lipids in Health & Disease. 22(1):166, 2023 Oct 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yu B; Hu M; Jiang W; Ma Y; Ye J; Wu Q; Guo W; Sun Y; Zhou M; Xu Y; Wu Z; Wang Y; Lam SM; Shui G; Gu J; Li JZ; Fu Z; Gong Y; Zhou H
+Author NameID
+ Fu, Zhenzhen; ORCID: http://orcid.org/0000-0002-4205-802X
+ Gong, Yingyun; ORCID: http://orcid.org/0000-0002-8570-6904
+ Zhou, Hongwen; ORCID: http://orcid.org/0000-0002-9309-3546
+Authors Full Name
+ Yu, Baowen; Hu, Moran; Jiang, Wanzi; Ma, Yizhe; Ye, Jingya; Wu, Qinyi; Guo, Wen; Sun, Yan; Zhou, Min; Xu, Yiwen; Wu, Zhoulu; Wang, Yiwen; Lam, Sin Man; Shui, Guanghou; Gu, Jingyu; Li, John Zhong; Fu, Zhenzhen; Gong, Yingyun; Zhou, Hongwen.
+Institution
+ Yu, Baowen. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Hu, Moran. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Jiang, Wanzi. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Ma, Yizhe. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Ye, Jingya. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Wu, Qinyi. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Guo, Wen. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Sun, Yan. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Zhou, Min. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Xu, Yiwen. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Wu, Zhoulu. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Wang, Yiwen. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Lam, Sin Man. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
+ Shui, Guanghou. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
+ Gu, Jingyu. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
+ Li, John Zhong. Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, China.
+ Fu, Zhenzhen. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. zhenzhen1127@foxmail.com.
+ Gong, Yingyun. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. gongyingyun@njmu.edu.cn.
+ Zhou, Hongwen. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. drhongwenzhou@njmu.edu.cn.
+ Zhou, Hongwen. Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, China. drhongwenzhou@njmu.edu.cn.
+MeSH Subject Headings
+ Adult
+ Humans
+ Ceramides
+ Obesity
+ *Insulin Resistance
+ Biomarkers
+ *Obesity, Metabolically Benign
+ Outcome Assessment, Health Care
+ *Metabolic Syndrome
+ Risk Factors
+ Body Mass Index
+Keyword Heading
+ Cardiovascular disease
+ Cer d18:1/24:1
+ Ceramide
+ Metabolically unhealthy obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The criteria for metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) remain controversial. This research aimed to identify a potential biomarker to differentiate the subtypes of obesity.
+
+ METHODS: The study conducted a lipidomic evaluation of ceramide in the serum of 77 Chinese adults who had undergone hyperinsulinemic-euglycemic clamps. These adults were divided into three groups according to the clinical data: normal weight control group (N = 21), MHO (N = 20), and MUO (N = 36).
+
+ RESULTS: The serum Cer d18:1/24:1 level in the MHO group was lower than that in the MUO group. As the Cer d18:1/24:1 level increased, insulin sensitivity decreased, and the unfavorable parameters increased in parallel. Multivariate logistic regression analysis revealed that serum Cer d18:1/24:1 levels were independently correlated with MUO in obesity. Individuals with higher levels of Cer d18:1/24:1 also had an elevated risk of cardiovascular disease. Most ceramide subtype levels increased in obesity compared to normal-weight individuals, but the levels of serum Cer d18:0/18:0 and Cer d18:1/16:0 decreased in obesity.
+
+ CONCLUSIONS: The relationships between ceramide subtypes and metabolic profiles might be heterogeneous in populations with different body weights. Cer d18:1/24:1 could be a biomarker that can be used to differentiate MUO from MHO, and to better predict who will develop unfavorable health outcomes among obese individuals.
+
+ TRIAL REGISTRATION: The First Affiliated Hospital of Nanjing Medical University's Institutional Review Board authorized this study protocol, and all participants provided written informed consent (2014-SR-003) prior to study entry. Copyright © 2023. BioMed Central Ltd., part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Ceramides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs12944-023-01921-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yu&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Ceramide+d18%3A1%2F24%3A1+as+a+potential+biomarker+to+differentiate+obesity+subtypes+with+unfavorable+health+outcomes.&volume=22&issue=1&spage=166&epage=&date=2023&doi=10.1186%2Fs12944-023-01921-0&pmid=37794463&sid=OVID:medline
+
+<182>
+Unique Identifier
+ 37755663
+Title
+ Anthropometric Measures of Adiposity as Markers of Kidney Dysfunction: A Cross-Sectional Study.
+Source
+ High Blood Pressure & Cardiovascular Prevention. 30(5):467-474, 2023 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vela-Bernal S; Facchetti R; Dell'Oro R; Quarti-Trevano F; Lurbe E; Mancia G; Grassi G
+Author NameID
+ Grassi, Guido; ORCID: http://orcid.org/0000-0003-1922-6547
+Authors Full Name
+ Vela-Bernal, Sara; Facchetti, Rita; Dell'Oro, Raffaella; Quarti-Trevano, Fosca; Lurbe, Empar; Mancia, Giuseppe; Grassi, Guido.
+Institution
+ Vela-Bernal, Sara. Cardiometabolic Risk and Diabetes Research Group, INCLIVA Biomedical Research Institute, Valencia, Spain.
+ Vela-Bernal, Sara. Internal Medicine Hospital Clinico de Valencia, Valencia, Spain.
+ Facchetti, Rita. Clinica Medica, Department of Medicine, University Milano-Bicocca, Via Pergolesi 33, 20052, Monza, Italy.
+ Dell'Oro, Raffaella. Clinica Medica, Department of Medicine, University Milano-Bicocca, Via Pergolesi 33, 20052, Monza, Italy.
+ Quarti-Trevano, Fosca. Clinica Medica, Department of Medicine, University Milano-Bicocca, Via Pergolesi 33, 20052, Monza, Italy.
+ Lurbe, Empar. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Lurbe, Empar. Department of Pediatrics, Consorcio Hospital General, University of Valencia, Valencia, Spain.
+ Mancia, Giuseppe. Clinica Medica, Department of Medicine, University Milano-Bicocca, Via Pergolesi 33, 20052, Monza, Italy.
+ Grassi, Guido. Clinica Medica, Department of Medicine, University Milano-Bicocca, Via Pergolesi 33, 20052, Monza, Italy. guido.grassi@unimib.it.
+MeSH Subject Headings
+ Humans
+ Middle Aged
+ Aged
+ *Adiposity
+ Cross-Sectional Studies
+ Waist Circumference
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Body Weight
+ Body Mass Index
+ Obesity, Abdominal/ep [Epidemiology]
+ Renal Insufficiency/co [Complications]
+ *Renal Insufficiency
+ Biomarkers
+ Kidney
+Keyword Heading
+ Epidemiological study
+ Obesity markers
+ Renal dysfunction
+ Waist-to-hip ratio
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The present study was designed to provide information on the ability of several different anthropometric markers to reflect the renal impairment associated with body weight increase and to predict the development of renal alterations linked to overweight and obesity. In 574 subjects representative of the general population of the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study, with an age range between 57 and 73 years, we investigated the association between different anthropometric markers of body fat, as alternative to body mass index, and renal failure, to obtain information useful for determining their potential predictive value. Renal dysfunction was significantly associated with almost all anthropometric markers of adiposity related to body weight and body shape. After adjustment for confounders, such as age, sex, office blood pressure, serum glucose, antihypertensive drugs and smoking habit, association remained significant only for waist-to-hip ratio (WHR), lipid accumulation product (LAP) and visceral adiposity index (VAI). These 3 markers also displayed at the receiver operating curves (ROC) analysis the best ability to detect subjects with or without kidney dysfunction. The results of the present study provide evidence that WHR, LAP and VAI represent the best markers of renal dysfunction associated with visceral body fat accumulation. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1007%2fs40292-023-00600-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vela-Bernal&issn=1120-9879&title=High+Blood+Pressure+%26+Cardiovascular+Prevention&atitle=Anthropometric+Measures+of+Adiposity+as+Markers+of+Kidney+Dysfunction%3A+A+Cross-Sectional+Study.&volume=30&issue=5&spage=467&epage=474&date=2023&doi=10.1007%2Fs40292-023-00600-6&pmid=37755663&sid=OVID:medline
+
+<183>
+Unique Identifier
+ 37749703
+Title
+ The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial.
+Source
+ Journal of Health, Population & Nutrition. 42(1):102, 2023 09 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sharifan P; Darroudi S; Rafiee M; Roustai Geraylow K; Hemmati R; Rashidmayvan M; Safarian M; Eslami S; Vatanparast H; Zare-Feizabadi R; Mohammadi-Bjgiran M; Ghazizadeh H; Khorasanchi Z; Bagherniya M; Ferns G; Rezaie M; Ghayour-Mobarhan M
+Author NameID
+ Sharifan, Payam; ORCID: http://orcid.org/0000-0002-6758-777X
+ Darroudi, Susan; ORCID: http://orcid.org/0000-0002-5377-729X
+ Rafiee, Mahdi; ORCID: http://orcid.org/0000-0001-8192-1618
+ Roustai Geraylow, Kiarash; ORCID: http://orcid.org/0000-0002-4366-6764
+ Hemmati, Romina; ORCID: http://orcid.org/0000-0003-4763-381X
+ Rashidmayvan, Mohammad; ORCID: http://orcid.org/0000-0003-3541-5604
+ Safarian, Mohamad; ORCID: http://orcid.org/0000-0002-0583-0412
+ Eslami, Saeid; ORCID: http://orcid.org/0000-0003-3755-1212
+ Vatanparast, Hassan; ORCID: http://orcid.org/0000-0003-2621-8385
+ Zare-Feizabadi, Reza; ORCID: http://orcid.org/0000-0002-0965-0590
+ Mohammadi-Bjgiran, Maryam; ORCID: http://orcid.org/0000-0002-7214-0315
+ Ghazizadeh, Hamideh; ORCID: http://orcid.org/0000-0002-0231-9547
+ Khorasanchi, Zahra; ORCID: http://orcid.org/0000-0001-9579-9465
+ Bagherniya, Mohammad; ORCID: http://orcid.org/0000-0002-5861-6129
+ Ferns, Gordon; ORCID: http://orcid.org/0000-0002-0957-8349
+ Rezaie, Mitra; ORCID: http://orcid.org/0000-0002-1965-4886
+ Ghayour-Mobarhan, Majid; ORCID: http://orcid.org/0000-0002-1081-6754
+Authors Full Name
+ Sharifan, Payam; Darroudi, Susan; Rafiee, Mahdi; Roustai Geraylow, Kiarash; Hemmati, Romina; Rashidmayvan, Mohammad; Safarian, Mohamad; Eslami, Saeid; Vatanparast, Hassan; Zare-Feizabadi, Reza; Mohammadi-Bjgiran, Maryam; Ghazizadeh, Hamideh; Khorasanchi, Zahra; Bagherniya, Mohammad; Ferns, Gordon; Rezaie, Mitra; Ghayour-Mobarhan, Majid.
+Institution
+ Sharifan, Payam. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Sharifan, Payam. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad, Iran.
+ Darroudi, Susan. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Rafiee, Mahdi. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad, Iran.
+ Roustai Geraylow, Kiarash. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad, Iran.
+ Hemmati, Romina. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad, Iran.
+ Rashidmayvan, Mohammad. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Rashidmayvan, Mohammad. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad, Iran.
+ Safarian, Mohamad. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Eslami, Saeid. Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Vatanparast, Hassan. College of Pharmacy and Nutrition, School of Public Health, University of Saskatchewan, Saskatoon, Canada.
+ Zare-Feizabadi, Reza. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Mohammadi-Bjgiran, Maryam. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ghazizadeh, Hamideh. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Khorasanchi, Zahra. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Khorasanchi, Zahra. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad, Iran.
+ Bagherniya, Mohammad. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Ferns, Gordon. Division of Medical Education, Brighton and Sussex Medical School, Room 346, Mayfield House, Falmer, Brighton, BN1 9PH, SSX, UK.
+ Rezaie, Mitra. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. rezaeim1@mums.ac.ir.
+ Ghayour-Mobarhan, Majid. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ghayourm@mums.ac.ir.
+ Ghayour-Mobarhan, Majid. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. ghayourm@mums.ac.ir.
+MeSH Subject Headings
+ Adult
+ Female
+ Humans
+ Male
+ Animals
+ Obesity, Abdominal/co [Complications]
+ *Obesity, Abdominal
+ Cholecalciferol/tu [Therapeutic Use]
+ *Cholecalciferol
+ Obesity
+ Milk
+ Vitamin D
+ Biomarkers
+ Liver
+Keyword Heading
+ Abdominal obesity
+ Liver function test
+ RCT
+ Randomized controlled trial
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Vitamin D deficiency has been reported to affect liver function biomarkers. This study was aimed to investigate the effect of consuming vitamin D fortified low-fat dairy products on liver function tests in adults with abdominal obesity.
+
+ METHODS: This total blinded randomized controlled trial was undertaken on otherwise healthy abdominally obese adults living in Mashhad, Iran. Milk and yogurt were fortified with 1500 IU vitamin D3 nano-capsules. Participants were randomized to receive fortified milk (n = 73), plain milk (n = 73), fortified yogurt (n = 69), and plain yogurt (n = 74) for 10 weeks. Blood samples were taken at baseline and at the end of the study to assess serum levels of vitamin D, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase (ALP), and Gamma glutamyl transferase.
+
+ RESULTS: A total of 289 participants completed the study (54% female). The groups were homogenous in terms of age, sex, weight, energy intake, and physical activity level (p-value > 0.05). After the trial, vitamin D serum levels were significantly increased in both groups receiving fortified products (both p < 0.001). There was a significant time*group effect only in serum ALP (p < 0.001).
+
+ CONCLUSION: Consumption of dairy products fortified by 1500 IU vitamin D3 might have detrimental effects on serum levels of some liver enzymes in individuals with abdominal obesity. Further studies needed to determine these effects and underlying mechanisms.
+
+ TRIAL REGISTRATION: IRCT20101130005280N27 . Copyright © 2023. BioMed Central Ltd., part of Springer Nature.
+Registry Number/Name of Substance
+ 1C6V77QF41 (Cholecalciferol). 1406-16-2 (Vitamin D). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs41043-023-00401-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sharifan&issn=1606-0997&title=Journal+of+Health%2C+Population+%26+Nutrition&atitle=The+effects+of+low-fat+dairy+products+fortified+with+1500+IU+vitamin+D3+on+serum+liver+function+biomarkers+in+adults+with+abdominal+obesity%3A+a+randomized+controlled+trial.&volume=42&issue=1&spage=102&epage=&date=2023&doi=10.1186%2Fs41043-023-00401-6&pmid=37749703&sid=OVID:medline
+
+<184>
+Unique Identifier
+ 37728925
+Title
+ Surrogate Adiposity Markers and Mortality.
+Source
+ JAMA Network Open. 6(9):e2334836, 2023 09 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khan I; Chong M; Le A; Mohammadi-Shemirani P; Morton R; Brinza C; Kiflen M; Narula S; Akhabir L; Mao S; Morrison K; Pigeyre M; Pare G
+Authors Full Name
+ Khan, Irfan; Chong, Michael; Le, Ann; Mohammadi-Shemirani, Pedrum; Morton, Robert; Brinza, Christina; Kiflen, Michel; Narula, Sukrit; Akhabir, Loubna; Mao, Shihong; Morrison, Katherine; Pigeyre, Marie; Pare, Guillaume.
+Institution
+ Khan, Irfan. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Khan, Irfan. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Khan, Irfan. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Khan, Irfan. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
+ Khan, Irfan. College of Medicine and Health, University College Cork, Cork, Ireland.
+ Chong, Michael. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Chong, Michael. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Chong, Michael. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Le, Ann. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Le, Ann. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Le, Ann. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Mohammadi-Shemirani, Pedrum. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Mohammadi-Shemirani, Pedrum. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Mohammadi-Shemirani, Pedrum. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Morton, Robert. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Morton, Robert. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Morton, Robert. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Brinza, Christina. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Brinza, Christina. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Brinza, Christina. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Brinza, Christina. School of Medicine, Queen's University, Kingston, Ontario, Canada.
+ Kiflen, Michel. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Kiflen, Michel. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Kiflen, Michel. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Kiflen, Michel. Temerty Faculty of Medicine, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada.
+ Narula, Sukrit. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Narula, Sukrit. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Narula, Sukrit. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Narula, Sukrit. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
+ Narula, Sukrit. Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
+ Akhabir, Loubna. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Akhabir, Loubna. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Akhabir, Loubna. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Mao, Shihong. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Mao, Shihong. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Mao, Shihong. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Morrison, Katherine. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Morrison, Katherine. Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
+ Morrison, Katherine. Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
+ Pigeyre, Marie. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Pigeyre, Marie. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Pigeyre, Marie. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Pare, Guillaume. Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
+ Pare, Guillaume. Thrombosis and Atherosclerosis Research Institute, David Barley Cardiac, Vascular and Stroke Research, Hamilton, Ontario, Canada.
+ Pare, Guillaume. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
+ Pare, Guillaume. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
+MeSH Subject Headings
+ Humans
+ Female
+ Male
+ Middle Aged
+ *Adiposity
+ Cohort Studies
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Body Fat Distribution
+ Biomarkers
+Abstract
+ Importance: Body mass index (BMI) is an easily obtained adiposity surrogate. However, there is variability in body composition and adipose tissue distribution between individuals with the same BMI, and there is controversy regarding the BMI associated with the lowest mortality risk.
+
+ Objective: To evaluate which of BMI, fat mass index (FMI), and waist-to-hip (WHR) has the strongest and most consistent association with mortality.
+
+ Design, Setting, and Participant: This cohort study used incident deaths from the UK Biobank (UKB; 2006-2022), which includes data from 22 clinical assessment centers across the United Kingdom. UKB British participants of British White ancestry (N = 387672) were partitioned into a discovery cohort (n = 337078) and validation cohort (n = 50594), with the latter consisting of 25297 deaths and 25297 controls. The discovery cohort was used to derive genetically determined adiposity measures while the validation cohort was used for analyses. Exposure-outcome associations were analyzed through observational and mendelian randomization (MR) analyses.
+
+ Exposures: BMI, FMI, and WHR.
+
+ Main Outcomes and Measures: All-cause and cause-specific (cancer, cardiovascular disease [CVD], respiratory disease, or other causes) mortality.
+
+ Results: There were 387672 and 50594 participants in our observational (mean [SD] age, 56.9 [8.0] years; 177340 [45.9%] male, 210332 [54.2%], female), and MR (mean [SD] age, 61.6 [6.2] years; 30031 [59.3%] male, 20563 [40.6%], female) analyses, respectively. Associations between measured BMI and FMI with all-cause mortality were J-shaped, whereas the association of WHR with all-cause mortality was linear using the hazard ratio (HR) scale (HR per SD increase of WHR, 1.41 [95% CI, 1.38-1.43]). Genetically determined WHR had a stronger association with all-cause mortality than BMI (odds ratio [OR] per SD increase of WHR, 1.51 [95% CI, 1.32-1.72]; OR per SD increase of BMI, 1.29 [95% CI, 1.20-1.38]; P for heterogeneity = .02). This association was stronger in male than female participants (OR, 1.89 [95% CI, 1.54-2.32]; P for heterogeneity = .01). Unlike BMI or FMI, the genetically determined WHR-all-cause mortality association was consistent irrespective of observed BMI.
+
+ Conclusions and Relevance: In this cohort study, WHR had the strongest and most consistent association with mortality irrespective of BMI. Clinical recommendations should consider focusing on adiposity distribution compared with mass.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1001%2fjamanetworkopen.2023.34836
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khan&issn=2574-3805&title=JAMA+Network+Open&atitle=Surrogate+Adiposity+Markers+and+Mortality.&volume=6&issue=9&spage=e2334836&epage=&date=2023&doi=10.1001%2Fjamanetworkopen.2023.34836&pmid=37728925&sid=OVID:medline
+
+<185>
+Unique Identifier
+ 37710187
+Title
+ Is neuregulin-1 (NRG-1) a potential blood biomarker linking depression to obesity? A case-control study.
+Source
+ BMC Psychiatry. 23(1):670, 2023 09 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abdelaziz HA; Abdelbaki TN; Dean YE; Assem S
+Authors Full Name
+ Abdelaziz, Heba Ahmed; Abdelbaki, Tamer Nabil; Dean, Yomna E; Assem, Sara.
+Institution
+ Abdelaziz, Heba Ahmed. Family Health, Mental Heath Department, High Institute of Public Health, Alexandria, Egypt.
+ Abdelbaki, Tamer Nabil. Faculty of Medicine, General Surgery Department, Alexandria University, Alexandria, Egypt.
+ Dean, Yomna E. Faculty of Medicine, Alexandria University, Alexandria, Egypt. yomna.mohamed1772@alexmed.edu.eg.
+ Assem, Sara. Faculty of Medicine, Medical Biochemistry Department, Alexandria University, Alexandria, Egypt.
+MeSH Subject Headings
+ Humans
+ *Bariatric Surgery
+ Biomarkers
+ Case-Control Studies
+ *Neuregulin-1
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+Keyword Heading
+ Depression
+ Gastrectomy
+ Neuregulin-1
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: No definite biomarker linking depression and obesity has been found yet. Our study aimed to investigate neuregulin-1 (NRG-1) as a potential blood biomarker for this association.
+
+ METHODS: A case-control study was conducted on 108 obese subjects assigned for laparoscopic sleeve gastrectomy and 100 non-obese controls. Depression was assessed pre- and post-operatively. Serum NRG-1 was measured.
+
+ RESULTS: Pre-operatively depression was significantly higher among obese compared to non-obese patients. After the operation, 1.9% of the severely depressed subjects reported no depression, while 5.6% became moderately depressed; about 6% of the moderately depressed and 16% of the mildly depressed became not depressed. Serum NRG-1 level was significantly lower among obese and severely depressed compared to the controls. It was negatively correlated to the level of depression pre- and post-operative (r = -0.764 and -0.467 respectively). The sensitivity of serum NRG1 as a predictor for depression pre- and post-operative was 92.45% and 52.94% respectively. Specificity was 69.09% and 79.73% respectively at cut-off values of <= 3.5 and <= 2.5 ng/ml.
+
+ CONCLUSION: NRG-1 is a possible biomarker for the diagnosis of depression pre-bariatric surgery and the prediction of its prognosis post-operatively. Copyright © 2023. BioMed Central Ltd., part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Neuregulin-1). 0 (NRG1 protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs12888-023-05160-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abdelaziz&issn=1471-244X&title=BMC+Psychiatry&atitle=Is+neuregulin-1+%28NRG-1%29+a+potential+blood+biomarker+linking+depression+to+obesity%3F+A+case-control+study.&volume=23&issue=1&spage=670&epage=&date=2023&doi=10.1186%2Fs12888-023-05160-6&pmid=37710187&sid=OVID:medline
+
+<186>
+Unique Identifier
+ 37704218
+Title
+ Identifying obesity subtypes: A review of studies utilising clinical biomarkers and genetic data. [Review]
+Source
+ Diabetic Medicine. 40(12):e15226, 2023 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abraham A; Yaghootkar H
+Author NameID
+ Abraham, Angela; ORCID: https://orcid.org/0000-0002-9010-8909
+Authors Full Name
+ Abraham, Angela; Yaghootkar, Hanieh.
+Institution
+ Abraham, Angela. Joseph Banks Laboratories, College of Health and Science, University of Lincoln, Lincoln, Lincolnshire, UK.
+ Yaghootkar, Hanieh. Joseph Banks Laboratories, College of Health and Science, University of Lincoln, Lincoln, Lincolnshire, UK.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Diabetes Mellitus, Type 2
+ Obesity/ge [Genetics]
+ Biomarkers
+Keyword Heading
+ adiposity
+ cardiovascular disease
+ ectopic fat
+ genetics
+ obesity
+ precision medicine
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a complex and multifactorial condition that poses significant health risks. Recent advancements in our understanding of obesity have highlighted the heterogeneity within this disorder. Identifying distinct subtypes of obesity is crucial for personalised treatment and intervention strategies. This review paper aims to examine studies that have utilised clinical biomarkers and genetic data to identify clusters or subtypes of obesity. The findings of these studies may provide valuable insights into the underlying mechanisms and potential targeted approaches for managing obesity-related health issues such as type 2 diabetes. Copyright © 2023 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1111%2fdme.15226
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abraham&issn=0742-3071&title=Diabetic+Medicine&atitle=Identifying+obesity+subtypes%3A+A+review+of+studies+utilising+clinical+biomarkers+and+genetic+data.&volume=40&issue=12&spage=e15226&epage=&date=2023&doi=10.1111%2Fdme.15226&pmid=37704218&sid=OVID:medline
+
+<187>
+Unique Identifier
+ 37686231
+Title
+ Tissue and Circulating MicroRNAs 378 and 142 as Biomarkers of Obesity and Its Treatment Response.
+Source
+ International Journal of Molecular Sciences. 24(17), 2023 Aug 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Matveev GA; Khromova NV; Zasypkin GG; Kononova YA; Vasilyeva EY; Babenko AY; Shlyakhto EV
+Author NameID
+ Matveev, Georgy A; ORCID: https://orcid.org/0000-0002-2695-4924
+Authors Full Name
+ Matveev, Georgy A; Khromova, Natalya V; Zasypkin, German G; Kononova, Yulia A; Vasilyeva, Elena Yu; Babenko, Alina Yu; Shlyakhto, Evgeny V.
+Institution
+ Matveev, Georgy A. World-Class Scientific Center "Center for Personalized Medicine", Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
+ Khromova, Natalya V. World-Class Scientific Center "Center for Personalized Medicine", Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
+ Zasypkin, German G. World-Class Scientific Center "Center for Personalized Medicine", Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
+ Kononova, Yulia A. World-Class Scientific Center "Center for Personalized Medicine", Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
+ Vasilyeva, Elena Yu. World-Class Scientific Center "Center for Personalized Medicine", Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
+ Babenko, Alina Yu. World-Class Scientific Center "Center for Personalized Medicine", Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
+ Shlyakhto, Evgeny V. World-Class Scientific Center "Center for Personalized Medicine", Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
+MeSH Subject Headings
+ Humans
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ *Cyclobutanes
+ Biomarkers
+ Obesity/ge [Genetics]
+Keyword Heading
+ miR-142
+ miR-378
+ obesity
+ subcutaneous adipose tissue (SAT)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Promising approaches to the treatment of obesity include increasing energy expenditure and slowing down fibrogenesis of adipose tissue. The neurotransmitter reuptake inhibitor sibutramine affects appetite and activates lipolysis in a catecholaminergic way. MicroRNAs (miRs) are considered as biomarkers of molecular genetic mechanisms underlying various processes. The profile of a number of miRs is altered in obesity, both in the circulation and in adipose tissue. The aim of this study was to assess the expression levels of miRs (hsa-miR-378a-3p, hsa-miR-142-3p) by real-time polymerase chain reaction in subcutaneous adipose tissue (SAT) and in plasma in patients with different degrees and duration of obesity and during sibutramine therapy. This study included 51 obese patients and 10 healthy subjects with normal weight who formed a control group. The study found that, before treatment, obese patients had no significant difference in the expression level of miR-378 in SAT and plasma compared to the control group, while the expression of miR-142 was significantly decreased in SAT and increased in plasma. A significant elevation in miR-378 expression level was noted in patients with first-degree obesity and duration of less than 10 years, and the decline in miR-142 increased with the duration of obesity. These data indicate a maximal increase in the expression of the adipogenesis inducer miR-378 in the early stages of obesity, a progressive decrease in the expression of the fibrogenesis inhibitor miR-142 in SAT with growth of duration of obesity and the likely presence of antifibrogenic effects of sibutramine realized through miR-142 activation.
+Registry Number/Name of Substance
+ WV5EC51866 (sibutramine). 0 (MicroRNAs). 0 (Cyclobutanes). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3390%2fijms241713426
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Matveev&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Tissue+and+Circulating+MicroRNAs+378+and+142+as+Biomarkers+of+Obesity+and+Its+Treatment+Response.&volume=24&issue=17&spage=13426&epage=&date=2023&doi=10.3390%2Fijms241713426&pmid=37686231&sid=OVID:medline
+
+<188>
+Unique Identifier
+ 37650320
+Title
+ Leptin receptor expression in blood mononuclear cells of lactating women is associated with infant body weight: Potential role as a molecular biomarker.
+Source
+ Pediatric Obesity. 18(11):e13072, 2023 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Malpeli A; Fasano MV; Sala M; Obregon P; Casado C; Mendez I; Fotia L; Castrogiovanni D; Varea A; Disalvo L; Tournier A; Mazziota L; Rocha D; Kruger AL; Orellano L; Andreoli MF
+Author NameID
+ Andreoli, Maria F; ORCID: https://orcid.org/0000-0001-8987-6348
+Authors Full Name
+ Malpeli, Agustina; Fasano, Maria Victoria; Sala, Marisa; Obregon, Pablo; Casado, Carla; Mendez, Ignacio; Fotia, Lucrecia; Castrogiovanni, Daniel; Varea, Ana; Disalvo, Liliana; Tournier, Andrea; Mazziota, Lucia; Rocha, Daniela; Kruger, Ana Luz; Orellano, Laura; Andreoli, Maria F.
+Institution
+ Malpeli, Agustina. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Fasano, Maria Victoria. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Fasano, Maria Victoria. Centro de Matematica de La Plata (CMaLP), Facultad de Ciencias Exactas, Universidad Nacional La Plata (UNLP) - CIC-PBA, La Plata, Argentina.
+ Sala, Marisa. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Obregon, Pablo. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Casado, Carla. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Mendez, Ignacio. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Fotia, Lucrecia. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Castrogiovanni, Daniel. Instituto Multidisciplinario de Biologia Celular (IMBICE), (UNLP - CIC-PBA - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)), La Plata, Argentina.
+ Varea, Ana. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Disalvo, Liliana. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Tournier, Andrea. Laboratorio Central, HIAEP "Sor Maria Ludovica" de La Plata, La Plata, Argentina.
+ Mazziota, Lucia. Laboratorio Central, HIAEP "Sor Maria Ludovica" de La Plata, La Plata, Argentina.
+ Rocha, Daniela. Laboratorio Central, HIAEP "Sor Maria Ludovica" de La Plata, La Plata, Argentina.
+ Kruger, Ana Luz. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Kruger, Ana Luz. CONICET, La Plata, Argentina.
+ Orellano, Laura. Laboratorio Central, HIAEP "Sor Maria Ludovica" de La Plata, La Plata, Argentina.
+ Andreoli, Maria F. Instituto de Desarrollo e Investigaciones Pediatricas (IDIP), HIAEP "Sor Maria Ludovica" de La Plata - Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CIC-PBA), La Plata, Argentina.
+ Andreoli, Maria F. CONICET, La Plata, Argentina.
+MeSH Subject Headings
+ Pregnancy
+ Infant
+ Female
+ Humans
+ Infant, Newborn
+ *Leptin
+ *Receptors, Leptin
+ Body Mass Index
+ Lactation
+ Milk, Human/me [Metabolism]
+ Leukocytes, Mononuclear/me [Metabolism]
+ Obesity/me [Metabolism]
+ Insulin
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ PBMC
+ biomarkers
+ insulin
+ lactation
+ leptin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Molecular biomarkers of maternal leptin resistance associated with infant weight are needed.
+
+ OBJECTIVES: To evaluate gene expression of leptin receptor (LEPR), suppressor of cytokine signalling 3 (SOCS3) and insulin receptor in peripheral blood mononuclear cells (PBMCs) of lactating women and their relationship with infant body weight and adiposity.
+
+ METHODS: At day 10 postpartum, maternal gene expression in PBMCs as well as leptin and insulin concentrations in plasma and milk were assessed (n = 68). Infant weight and BMI z-scores, skinfolds and arm circumference were obtained at 10 days and/or at 3 months old.
+
+ RESULTS: In mothers with pre-pregnancy overweight or obesity (OW/OB), LEPR expression was reduced (p = 0.013) whereas plasma and milk leptin and milk insulin concentrations were elevated. LEPR expression was positively related with infant weight z-score (Beta (95% CI): 0.40 (0.17, 0.63), p = 0.001) but not with leptin concentrations. SOCS3 expression was positively related with infant weight z-score (Beta (95% CI): 0.28 (0.04, 0.51), p = 0.024) and arm circumference (Beta (95% CI): 0.57 (0.32, 0.82), p < 0.001). Relationships remained significant after adjusting for maternal and infant confounders.
+
+ CONCLUSIONS: LEPR and SOCS3 gene expression in PBMCs are novel maternal molecular biomarkers that reflect leptin resistance and are associated with infant body weight and adiposity. Copyright © 2023 World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (Leptin). 0 (Receptors, Leptin). 0 (Insulin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1111%2fijpo.13072
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Malpeli&issn=2047-6302&title=Pediatric+Obesity&atitle=Leptin+receptor+expression+in+blood+mononuclear+cells+of+lactating+women+is+associated+with+infant+body+weight%3A+Potential+role+as+a+molecular+biomarker.&volume=18&issue=11&spage=e13072&epage=&date=2023&doi=10.1111%2Fijpo.13072&pmid=37650320&sid=OVID:medline
+
+<189>
+Unique Identifier
+ 37640458
+Title
+ Single-centre, non-randomised clinical trial at a tertiary care centre to investigate 1-year changes in social experiences and biomarkers of well-being after bariatric surgery in individuals with severe obesity: protocol for the Bariatric Surgery and Social Experiences (BaSES) study.
+Source
+ BMJ Open. 13(8):e071332, 2023 08 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pfabigan DM; Hertel JK; Svanevik M; Lindberg M; Sailer U; Hjelmesaeth J
+Author NameID
+ Pfabigan, Daniela Melitta; ORCID: https://orcid.org/0000-0002-4043-1695
+ Hertel, Jens Kristoffer; ORCID: https://orcid.org/0000-0002-8693-7018
+ Svanevik, Marius; ORCID: https://orcid.org/0000-0003-4303-5935
+ Lindberg, Morten; ORCID: https://orcid.org/0000-0002-5568-7810
+ Sailer, Uta; ORCID: https://orcid.org/0000-0002-9728-8738
+ Hjelmesaeth, Joran; ORCID: https://orcid.org/0000-0002-1995-0562
+Authors Full Name
+ Pfabigan, Daniela Melitta; Hertel, Jens Kristoffer; Svanevik, Marius; Lindberg, Morten; Sailer, Uta; Hjelmesaeth, Joran.
+Institution
+ Pfabigan, Daniela Melitta. Department of Behavioural Medicine, University of Oslo, Oslo, Norway daniela.pfabigan@uib.no.
+ Pfabigan, Daniela Melitta. Department of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tonsberg, Norway.
+ Pfabigan, Daniela Melitta. Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
+ Hertel, Jens Kristoffer. Department of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tonsberg, Norway.
+ Svanevik, Marius. Department of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tonsberg, Norway.
+ Svanevik, Marius. Department of Gastrointestinal Surgery, Vestfold Hospital Trust, Tonsberg, Norway.
+ Lindberg, Morten. Department of Medical Biochemistry, Vestfold Hospital Trust, Tonsberg, Norway.
+ Sailer, Uta. Department of Behavioural Medicine, University of Oslo, Oslo, Norway.
+ Hjelmesaeth, Joran. Department of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tonsberg, Norway.
+ Hjelmesaeth, Joran. Department of Endocrinology, Morbid Obesity and Preventive Medicine, University of Oslo, Oslo, Norway.
+MeSH Subject Headings
+ Humans
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+ Tertiary Care Centers
+ Obesity
+ *Bariatric Surgery
+ *Gastric Bypass
+ Biomarkers
+Keyword Heading
+ gastroenterology
+ mental health
+ morbid anatomy
+ nutrition & dietetics
+ quality of life
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity is linked to increased loneliness and less enjoyment of social interactions. While bariatric surgery is the most effective treatment targeting severe obesity, there is limited understanding as to whether patients experience social interactions differently after surgery. The Bariatric Surgery and Social Experiences study is designed to assess potential changes in how much patients enjoy and engage in daily social interactions 1 year after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG).
+
+ METHODS AND ANALYSIS: Single-centre, non-randomised clinical trial carried out at the Department of Endocrinology, Obesity and Nutrition at Vestfold Hospital Trust, Norway. Eligible patients (N=113) will undergo either RYGB, SG or single anastomosis sleeve ileal (SASI) bypass. The primary outcome measure is change in the social experience score (assessed with a questionnaire) from a presurgery to a follow-up assessment 1 year after RYGB and SG. The respective changes after SASI bypass will be assessed and considered exploratory.
+
+ ETHICS AND DISSEMINATION: The most recent protocol version of this study was reviewed and approved by the Regional Committee for Medical Research Ethics South East Norway (REK sor-ost A) on 29 August 2022 (ref: 238406). The results will be disseminated to academic and health professional audiences and the public via publications in international peer-reviewed journals and conferences.
+
+ TRIAL REGISTRATION NUMBER: NCT05207917. Copyright © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1136%2fbmjopen-2022-071332
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pfabigan&issn=2044-6055&title=BMJ+Open&atitle=Single-centre%2C+non-randomised+clinical+trial+at+a+tertiary+care+centre+to+investigate+1-year+changes+in+social+experiences+and+biomarkers+of+well-being+after+bariatric+surgery+in+individuals+with+severe+obesity%3A+protocol+for+the+Bariatric+Surgery+and+Social+Experiences+%28BaSES%29+study.&volume=13&issue=8&spage=e071332&epage=&date=2023&doi=10.1136%2Fbmjopen-2022-071332&pmid=37640458&sid=OVID:medline
+
+<190>
+Unique Identifier
+ 37598352
+Title
+ Associations between changes of smartphone pedometer-assessed step counts and levels of obesity-related breast cancer biomarkers in non-cancer women: A population-based observational study.
+Source
+ Journal of Sports Sciences. 41(10):937-946, 2023 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhao X; Liu X; Wu X; Fu P; Zhang X; Zhou M; Hao Y; Xu B; Yan L; Xiao J; Li X; Lv L; Yang H; Liu Z; Yang C; Wang X; Liao J; Jiang X; Zhang B; Li J
+Authors Full Name
+ Zhao, Xunying; Liu, Xiaohua; Wu, Xueyao; Fu, Ping; Zhang, Xiaofan; Zhou, Min; Hao, Yu; Xu, Bin; Yan, Lanping; Xiao, Jinyu; Li, Xingyue; Lv, Liang; Yang, Huifang; Liu, Zhenmi; Yang, Chunxia; Wang, Xin; Liao, Jiaqiang; Jiang, Xia; Zhang, Ben; Li, Jiayuan.
+Institution
+ Zhao, Xunying. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Liu, Xiaohua. Department of Maternal and Child Health, Chengdu Shuangliu District Maternal and Child Health Care Hospital, Chengdu, Sichuan, China.
+ Wu, Xueyao. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Fu, Ping. Department of Maternal and Child Health, Chengdu Shuangliu District Maternal and Child Health Care Hospital, Chengdu, Sichuan, China.
+ Zhang, Xiaofan. Department of Scientific Research & Management, The Second People's Hospital of Guiyang, Guiyang, China.
+ Zhou, Min. Department of Maternal and Child Health, Chengdu Shuangliu District Maternal and Child Health Care Hospital, Chengdu, Sichuan, China.
+ Hao, Yu. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Xu, Bin. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Yan, Lanping. Department of Maternal and Child Health, Chengdu Shuangliu District Maternal and Child Health Care Hospital, Chengdu, Sichuan, China.
+ Xiao, Jinyu. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Li, Xingyue. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Lv, Liang. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Yang, Huifang. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Liu, Zhenmi. Department of Maternal, Child and Adolescent Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
+ Yang, Chunxia. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Wang, Xin. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Liao, Jiaqiang. Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
+ Jiang, Xia. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Jiang, Xia. Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
+ Zhang, Ben. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Zhang, Ben. Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
+ Li, Jiayuan. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+MeSH Subject Headings
+ Humans
+ Female
+ *Biomarkers, Tumor
+ Actigraphy
+ Smartphone
+ C-Reactive Protein
+ *Breast Neoplasms
+ Obesity
+ Biomarkers
+Keyword Heading
+ Physical activity
+ biomarker
+ breast cancer
+ obesity
+ step count
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ While a higher level of physical activity (PA) is inversely associated with a higher breast cancer (BC) risk, the health benefits of daily steps on obesity-related BC biomarkers remain unclear. We aimed to understand the associations of changes in step counts with levels of five obesity-related BC biomarkers during a two-year follow-up. In total, 144 non-cancer women (47.96 +/- 5.72) were observed on both 2019 and 2021. A structured questionnaire, daily steps and fasting blood samples were collected before (t0, 2019) and after (t1, 2021). Levels of biomarkers (IGF-binding proteins 3, adiponectin, soluble leptin receptor, C-reactive protein, and resistin) were assayed by ELISA. Participants were divided into persistent low steps, decreasing steps, increasing steps, and persistent high steps. Associations of categories on proposed biomarkers were estimated using linear regression models, with persistent low steps as reference. Associations between time-varying step counts with biomarkers were quantified using mixed linear models. Compared with persistent low steps, increasing steps is associated with a reduction in C-reactive protein level (beta=-0.74, 95%CI=-1.23--0.26, P-value = 2.98 x 10-3). An inverse association between time-varying step counts with C-reactive protein level was identified, consistent across different obesity types and baseline step level categories. No association with daily step counts was observed for other proteins.
+Registry Number/Name of Substance
+ 0 (Biomarkers, Tumor). 9007-41-4 (C-Reactive Protein). 0 (Biomarkers).
+Publication Type
+ Observational Study. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1080%2f02640414.2023.2249754
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhao&issn=0264-0414&title=Journal+of+Sports+Sciences&atitle=Associations+between+changes+of+smartphone+pedometer-assessed+step+counts+and+levels+of+obesity-related+breast+cancer+biomarkers+in+non-cancer+women%3A+A+population-based+observational+study.&volume=41&issue=10&spage=937&epage=946&date=2023&doi=10.1080%2F02640414.2023.2249754&pmid=37598352&sid=OVID:medline
+
+<191>
+Unique Identifier
+ 37597653
+Title
+ Joint-adjacent subcutaneous adipose tissue - An obesity-related imaging biomarker associated with structural osteoarthritis progression?.
+Source
+ Osteoarthritis & Cartilage. 31(11):1420-1422, 2023 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wirth W
+Authors Full Name
+ Wirth, Wolfgang.
+Institution
+ Wirth, Wolfgang. Department for Imaging and Functional Musculoskeletal Research, Institute of Anatomy and Cell Biology, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Freilassing, Germany. Electronic address: wolfgang.wirth@pmu.ac.at.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Humans
+ Osteoarthritis/dg [Diagnostic Imaging]
+ Osteoarthritis/co [Complications]
+ *Osteoarthritis
+ Subcutaneous Fat/dg [Diagnostic Imaging]
+ Obesity/co [Complications]
+ Biomarkers
+ Adipose Tissue
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.joca.2023.08.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wirth&issn=1063-4584&title=Osteoarthritis+%26+Cartilage&atitle=Joint-adjacent+subcutaneous+adipose+tissue+-+An+obesity-related+imaging+biomarker+associated+with+structural+osteoarthritis+progression%3F.&volume=31&issue=11&spage=1420&epage=1422&date=2023&doi=10.1016%2Fj.joca.2023.08.002&pmid=37597653&sid=OVID:medline
+
+<192>
+Unique Identifier
+ 37580231
+Title
+ No effect of multi-strain probiotic supplementation on metabolic and inflammatory markers and newborn body composition in pregnant women with obesity: Results from a randomized, double-blind placebo-controlled study.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 33(12):2444-2454, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Halkjaer SI; de Knegt VE; Kallemose T; Jensen JB; Cortes D; Gluud LL; Wewer Albrechtsen NJ; Petersen AM
+Authors Full Name
+ Halkjaer, Sofie I; de Knegt, Victoria E; Kallemose, Thomas; Jensen, Jens-Erik B; Cortes, Dina; Gluud, Lise L; Wewer Albrechtsen, Nicolai J; Petersen, Andreas Munk.
+Institution
+ Halkjaer, Sofie I. Gastrounit, Medical Section, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark.
+ de Knegt, Victoria E. Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark.
+ Kallemose, Thomas. Clinical Research Center, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark.
+ Jensen, Jens-Erik B. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Endocrinology, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark.
+ Cortes, Dina. Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Gluud, Lise L. Gastrounit, Medical Section, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Wewer Albrechtsen, Nicolai J. Department for Clinical Biochemistry, University Hospital Copenhagen - Bispebjerg, Copenhagen, Denmark.
+ Petersen, Andreas Munk. Gastrounit, Medical Section, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark. Electronic address: andreas.munk.petersen@regionh.dk.
+MeSH Subject Headings
+ Pregnancy
+ Infant, Newborn
+ Female
+ Humans
+ *Pregnant Women
+ Glucagon
+ Obesity/di [Diagnosis]
+ Obesity/th [Therapy]
+ Probiotics/ae [Adverse Effects]
+ *Probiotics
+ Body Composition
+ Biomarkers
+ Glucagon-Like Peptide 1
+ Double-Blind Method
+Keyword Heading
+ Metabolism
+ Obesity
+ Offspring body composition
+ Pregnancy
+ Probiotics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Modulation of the gut microbiome composition with probiotics may have beneficial metabolic effects in pregnant women with obesity. The aim was to investigate the effect of probiotic supplementation during pregnancy on metabolic and inflammatory markers and the body composition of the offspring.
+
+ METHODS AND RESULTS: A randomized double-blind trial in 50 pregnant women (pre-pregnancy BMI >=30 and < 35 kg/m2) comparing multi-strain probiotics (Vivomixx R; 450 billion CFU/d) versus placebo from 14 to 20 weeks of gestation until delivery was carried out. Participants were followed with two predelivery visits at gestational week 27-30 and 36-37 and with one postdelivery visit. All visits included fasting blood samples (C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), insulin, C-peptide, glucose, glucagon, and glucagon-like peptide-1 (GLP-1)). At delivery, umbilical cord blood samples were collected (GLP-1 and glucagon). At the postdelivery visit, a dual-energy X-ray absorptiometry (DXA) scan of the newborn was performed. Forty-nine of 50 participants completed the study until delivery, and 36 mother-offspring dyads underwent postdelivery examinations including a DXA scan. There were no significant differences in changes in measured biomarkers between the probiotic versus the placebo group. No differences were found in newborn body composition or GLP-1 and glucagon. GLP-1 measured in umbilical blood samples was positively correlated to fat percent in offspring from the probiotic group.
+
+ CONCLUSION: In this study of pregnant women with obesity and their newborns, there was no effect of probiotic supplementation in mothers or babies on metabolic or inflammatory biomarkers or on body composition of offspring. This study was registered at clinicaltrials.gov as NCT02508844. Copyright © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 9007-92-5 (Glucagon). 0 (Biomarkers). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.numecd.2023.07.030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Halkjaer&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=No+effect+of+multi-strain+probiotic+supplementation+on+metabolic+and+inflammatory+markers+and+newborn+body+composition+in+pregnant+women+with+obesity%3A+Results+from+a+randomized%2C+double-blind+placebo-controlled+study.&volume=33&issue=12&spage=2444&epage=2454&date=2023&doi=10.1016%2Fj.numecd.2023.07.030&pmid=37580231&sid=OVID:medline
+
+<193>
+Unique Identifier
+ 37574495
+Title
+ The association between dietary pattern and visceral adiposity index, triglyceride-glucose index, inflammation, and body composition among Iranian overweight and obese women.
+Source
+ Scientific Reports. 13(1):13162, 2023 08 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gholami F; Karimi Z; Samadi M; Sovied N; Yekaninejad MS; Keshavarz SA; Javdan G; Bahrampour N; Wong A; Clark CCT; Mirzaei K
+Authors Full Name
+ Gholami, Fatemeh; Karimi, Zahra; Samadi, Mahsa; Sovied, Neda; Yekaninejad, Mir Saeid; Keshavarz, Seyed Ali; Javdan, Gholamali; Bahrampour, Niki; Wong, Alexei; Clark, Cain C T; Mirzaei, Khadijeh.
+Institution
+ Gholami, Fatemeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Karimi, Zahra. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran.
+ Samadi, Mahsa. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Sovied, Neda. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Yekaninejad, Mir Saeid. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran.
+ Keshavarz, Seyed Ali. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Javdan, Gholamali. Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
+ Bahrampour, Niki. Department of Nutrition, Science and Research Branch, Islamic Azad University (SRBIAU), Tehran, Iran.
+ Wong, Alexei. Department of Health and Human Performance, Marymount University, Arlington, VA, USA.
+ Clark, Cain C T. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, UK.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran. mirzaei_kh@tums.ac.ir.
+MeSH Subject Headings
+ Humans
+ Female
+ Overweight/co [Complications]
+ *Overweight
+ Iran
+ *Glucose
+ Adiposity
+ Triglycerides
+ Cross-Sectional Studies
+ Obesity/co [Complications]
+ Diet/ae [Adverse Effects]
+ Obesity, Abdominal/co [Complications]
+ Body Composition
+ Biomarkers
+ Inflammation/co [Complications]
+ Body Mass Index
+Abstract
+ The aim of the present study was to investigate the association between dietary patterns, derived through latent class analysis (LCA), with visceral adiposity index (VAI), Triglyceride-Glucose Index (TyG), inflammation biomarkers, and body composition in overweight and obese Iranian women. For this cross-sectional study, dietary exposure was assessed using a validated 147-item semi-quantitative food frequency questionnaire (FFQ). Dietary patterns were derived through LCA. Binary logistic was performed to test the associations of dietary patterns with VAI, TyG, inflammation biomarkers, and body composition. Health centers in Tehran, Iran. 376 obese and overweight women, aged > 18 years. Two dietary patterns were identified using LCA modeling: healthy and unhealthy. Women in the unhealthy class were characterized by higher consumption of fast food, sweetened beverages, grains, unhealthy oils, butter and margarine, and snacks. Compared with the healthy class, the unhealthy class was associated with an increased risk of higher fasting blood sugar (FBS) (OR = 6.07; 95% CI: 1.33-27.74, P value = 0.02), c-reactive protein (CRP) (OR = 1.72; 95% CI: 1.05-2.80; P value = 0.02), and lower fat free mass index (FFMI) (OR = 0.56; 95% CI: 0.35-0.88, P value = 0.01), after adjusting for confounders. We found that adherence to an unhealthy dietary pattern was associated with decreased FFMI and increased FBS and CRP using LCA, but not with the rest of the variables. Further studies should be conducted to confirm the veracity of these findings. Copyright © 2023. Springer Nature Limited.
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41598-023-39653-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gholami&issn=2045-2322&title=Scientific+Reports&atitle=The+association+between+dietary+pattern+and+visceral+adiposity+index%2C+triglyceride-glucose+index%2C+inflammation%2C+and+body+composition+among+Iranian+overweight+and+obese+women.&volume=13&issue=1&spage=13162&epage=&date=2023&doi=10.1038%2Fs41598-023-39653-x&pmid=37574495&sid=OVID:medline
+
+<194>
+Unique Identifier
+ 37571355
+Title
+ Compliance with Nutritional Recommendations and Gut Microbiota Profile in Galician Overweight/Obese and Normal-Weight Individuals.
+Source
+ Nutrients. 15(15), 2023 Aug 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sinisterra-Loaiza L; Alonso-Lovera P; Cardelle-Cobas A; Miranda JM; Vazquez BI; Cepeda A
+Author NameID
+ Cardelle-Cobas, Alejandra; ORCID: https://orcid.org/0000-0002-1271-513X
+ Miranda, Jose Manuel; ORCID: https://orcid.org/0000-0001-7992-1491
+ Vazquez, Beatriz I; ORCID: https://orcid.org/0000-0001-9305-0151
+ Cepeda, Alberto; ORCID: https://orcid.org/0000-0002-9324-1342
+Authors Full Name
+ Sinisterra-Loaiza, Laura; Alonso-Lovera, Patricia; Cardelle-Cobas, Alejandra; Miranda, Jose Manuel; Vazquez, Beatriz I; Cepeda, Alberto.
+Institution
+ Sinisterra-Loaiza, Laura. Laboratorio de Higiene, Inspeccion y Control de Alimentos, Departamento de Quimica Analitica, Nutricion y Bromatologia, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain.
+ Alonso-Lovera, Patricia. Laboratorio de Higiene, Inspeccion y Control de Alimentos, Departamento de Quimica Analitica, Nutricion y Bromatologia, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain.
+ Cardelle-Cobas, Alejandra. Laboratorio de Higiene, Inspeccion y Control de Alimentos, Departamento de Quimica Analitica, Nutricion y Bromatologia, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain.
+ Miranda, Jose Manuel. Laboratorio de Higiene, Inspeccion y Control de Alimentos, Departamento de Quimica Analitica, Nutricion y Bromatologia, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain.
+ Vazquez, Beatriz I. Laboratorio de Higiene, Inspeccion y Control de Alimentos, Departamento de Quimica Analitica, Nutricion y Bromatologia, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain.
+ Cepeda, Alberto. Laboratorio de Higiene, Inspeccion y Control de Alimentos, Departamento de Quimica Analitica, Nutricion y Bromatologia, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain.
+MeSH Subject Headings
+ Humans
+ Overweight/mi [Microbiology]
+ *Overweight
+ *Gastrointestinal Microbiome
+ Obesity/mi [Microbiology]
+ Diet
+ Body Mass Index
+ Biomarkers
+Keyword Heading
+ BMI
+ fiber
+ gut microbiota
+ monounsaturated fatty acids
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Different research studies have identified specific groups or certain dietary compounds as the onset and progression of obesity and suggested that gut microbiota is a mediator between these compounds and the inflammation associated with pathology. In this study, the objective was to evaluate the dietary intake of 108 overweight (OW), obese (OB), and normal-weight (NW) individuals and to analyze their gut microbiota profile to determine changes and associations with Body Mass Index (BMI) and diet. When individuals were compared by BMI, significant differences in fiber and monounsaturated fatty acids (MUFAs) intake were observed, showing higher adequacy for the NW group. The analysis of gut microbiota showed statistical differences for 18 ASVs; Anaerostipes and Faecalibacterium decreased in the OW/OB group, whereas the genus Oscillospira increased; the genus was also found in the LEFSe analysis as a biomarker for OW/OB. Roseburia faecis was found in a significantly higher proportion of NW individuals and identified as a biomarker for the NW group. Correlation analysis showed that adequation to nutritional recommendation for fiber indicated a higher abundance of Prevotella copri, linearly correlated with F. prausnitzii, Bacteroides caccae, and R. faecis. The same correlation was found for the adequation for MUFAs, with these bacteria being more abundant when the intake was adjusted to or below the recommendations.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3390%2fnu15153418
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sinisterra-Loaiza&issn=2072-6643&title=Nutrients&atitle=Compliance+with+Nutritional+Recommendations+and+Gut+Microbiota+Profile+in+Galician+Overweight%2FObese+and+Normal-Weight+Individuals.&volume=15&issue=15&spage=&epage=&date=2023&doi=10.3390%2Fnu15153418&pmid=37571355&sid=OVID:medline
+
+<195>
+Unique Identifier
+ 37571275
+Title
+ Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial.
+Source
+ Nutrients. 15(15), 2023 Jul 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schmidt KA; Mokhtari P; Holzhausen EA; Alderete TL; Allayee H; Nayak KS; Sinatra FR; Pickering TA; Mack W; Kohli R; Goran MI
+Author NameID
+ Schmidt, Kelsey A; ORCID: https://orcid.org/0000-0002-9916-1634
+ Holzhausen, Elizabeth A; ORCID: https://orcid.org/0000-0002-1773-0099
+ Alderete, Tanya L; ORCID: https://orcid.org/0000-0002-7751-9543
+ Allayee, Hooman; ORCID: https://orcid.org/0000-0002-2384-5239
+ Nayak, Krishna S; ORCID: https://orcid.org/0000-0001-5735-3550
+ Pickering, Trevor A; ORCID: https://orcid.org/0000-0002-2281-641X
+ Mack, Wendy; ORCID: https://orcid.org/0000-0002-2474-7921
+ Goran, Michael I; ORCID: https://orcid.org/0000-0002-6897-6961
+Authors Full Name
+ Schmidt, Kelsey A; Mokhtari, Pari; Holzhausen, Elizabeth A; Alderete, Tanya L; Allayee, Hooman; Nayak, Krishna S; Sinatra, Frank R; Pickering, Trevor A; Mack, Wendy; Kohli, Rohit; Goran, Michael I.
+Institution
+ Schmidt, Kelsey A. Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop #61, Los Angeles, CA 90027, USA.
+ Mokhtari, Pari. Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop #61, Los Angeles, CA 90027, USA.
+ Holzhausen, Elizabeth A. Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.
+ Alderete, Tanya L. Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.
+ Allayee, Hooman. Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90033, USA.
+ Nayak, Krishna S. Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA 90089, USA.
+ Nayak, Krishna S. Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
+ Sinatra, Frank R. Department of Pediatrics, University of Southern California, Los Angeles, CA 90033, USA.
+ Pickering, Trevor A. Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90033, USA.
+ Mack, Wendy. Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90033, USA.
+ Kohli, Rohit. Division of Gastroenterology and Hepatology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
+ Goran, Michael I. Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop #61, Los Angeles, CA 90027, USA.
+MeSH Subject Headings
+ Adolescent
+ Humans
+ Biomarkers
+ Carbohydrates
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Cross-Sectional Studies
+ *Dietary Sugars
+ Hispanic or Latino
+ Obesity
+ Triglycerides
+ Tumor Necrosis Factor-alpha
+ *Cardiometabolic Risk Factors
+Keyword Heading
+ Latino
+ adolescents
+ glucose tolerance
+ metabolic disease
+ obesity
+ sugar
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pediatric obesity and cardiometabolic disease disproportionately impact minority communities. Sugar reduction is a promising prevention strategy with consistent cross-sectional associations of increased sugar consumption with unfavorable biomarkers of cardiometabolic disease. Few trials have tested the efficacy of pediatric sugar reduction interventions. Therefore, in a parallel-design trial, we randomized Latino youth with obesity (BMI >= 95th percentile) [n = 105; 14.8 years] to control (standard diet advice) or sugar reduction (clinical intervention with a goal of <=10% of calories from free sugar) for 12-weeks. Outcomes included changes in glucose tolerance and its determinants as assessed by a 2-h frequently sample oral glucose tolerance test, fasting serum lipid profile (total cholesterol, HDL, LDL, triglycerides, cholesterol:HDL), and inflammatory markers (CRP, IL-6, TNF-alpha). Free sugar intake decreased in the intervention group compared to the control group [11.5% to 7.3% vs. 13.9% to 10.7% (% Energy), respectively, p = 0.02], but there were no effects on any outcome of interest (pall > 0.07). However, an exploratory analysis revealed that sugar reduction, independent of randomization, was associated with an improved Oral-disposition index (p < 0.001), triglycerides (p = 0.049), and TNF-alpha (p = 0.02). Dietary sugar reduction may have the potential to reduce chronic disease risks through improvements in beta-cell function, serum triglycerides, and inflammatory markers in Latino adolescents with obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Carbohydrates). 0 (Dietary Sugars). 0 (Triglycerides). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3390%2fnu15153338
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schmidt&issn=2072-6643&title=Nutrients&atitle=Effects+of+Dietary+Sugar+Reduction+on+Biomarkers+of+Cardiometabolic+Health+in+Latino+Youth%3A+Secondary+Analyses+from+a+Randomized+Controlled+Trial.&volume=15&issue=15&spage=&epage=&date=2023&doi=10.3390%2Fnu15153338&pmid=37571275&sid=OVID:medline
+
+<196>
+Unique Identifier
+ 37560987
+Title
+ Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery. [Review]
+Source
+ Current Opinion in Lipidology. 34(5):221-233, 2023 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bashir B; Adam S; Ho JH; Linn Z; Durrington PN; Soran H
+Authors Full Name
+ Bashir, Bilal; Adam, Safwaan; Ho, Jan H; Linn, Zara; Durrington, Paul N; Soran, Handrean.
+Institution
+ Bashir, Bilal. Faculty of Biology, Medicine and Health, University of Manchester.
+ Bashir, Bilal. Centre for Endocrinology, Diabetes and Metabolism, Peter Mount Building, Manchester University NHS Foundation Trust.
+ Adam, Safwaan. The Christie NHS Foundation Trust, Manchester, UK.
+ Ho, Jan H. The Christie NHS Foundation Trust, Manchester, UK.
+ Linn, Zara. Faculty of Biology, Medicine and Health, University of Manchester.
+ Durrington, Paul N. Faculty of Biology, Medicine and Health, University of Manchester.
+ Soran, Handrean. Faculty of Biology, Medicine and Health, University of Manchester.
+ Soran, Handrean. Centre for Endocrinology, Diabetes and Metabolism, Peter Mount Building, Manchester University NHS Foundation Trust.
+MeSH Subject Headings
+ Humans
+ Metabolic Syndrome/co [Complications]
+ *Metabolic Syndrome
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Risk Factors
+ Cardiovascular Diseases/co [Complications]
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Obesity/co [Complications]
+ Bariatric Surgery/ae [Adverse Effects]
+ *Bariatric Surgery
+ Heart Disease Risk Factors
+ Biomarkers
+ Sleep Apnea, Obstructive/co [Complications]
+ *Sleep Apnea, Obstructive
+Abstract
+ PURPOSE OF REVIEW: The aim of this review was to provide an overview of the role of novel biomarkers in metabolic syndrome, their association with cardiovascular risk and the impact of bariatric surgery on these biomarkers.
+
+ RECENT FINDINGS: Metabolic syndrome encompasses an intricate network of health problems, and its constituents extend beyond the components of its operational definition. Obesity-related dyslipidaemia not only leads to quantitative changes in lipoprotein concentration but also alteration in qualitative composition of various lipoprotein subfractions, including HDL particles, rendering them proatherogenic. This is compounded by the concurrent existence of obstructive sleep apnoea (OSA) and nonalcoholic fatty liver disease (NAFLD), which pave the common pathway to inflammation and oxidative stress culminating in heightened atherosclerotic cardiovascular disease (ASCVD) risk. Bariatric surgery is an exceptional modality to reverse both conventional and less recognised aspects of metabolic syndrome. It reduces the burden of atherosclerosis by ameliorating the impact of obesity and its related complications (OSA, NAFLD) on quantitative and qualitative composition of lipoproteins, ultimately improving endothelial function and cardiovascular morbidity and mortality.
+
+ SUMMARY: Several novel biomarkers, which are not traditionally considered as components of metabolic syndrome play a crucial role in determining ASCVD risk in metabolic syndrome. Due to their independent association with ASCVD, it is imperative that these are addressed. Bariatric surgery is a widely recognized intervention to improve the conventional risk factors associated with metabolic syndrome; however, it also serves as an effective treatment to optimize novel biomarkers. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Review. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1097%2fMOL.0000000000000889
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bashir&issn=0957-9672&title=Current+Opinion+in+Lipidology&atitle=Established+and+potential+cardiovascular+risk+factors+in+metabolic+syndrome%3A+Effect+of+bariatric+surgery.&volume=34&issue=5&spage=221&epage=233&date=2023&doi=10.1097%2FMOL.0000000000000889&pmid=37560987&sid=OVID:medline
+
+<197>
+Unique Identifier
+ 37542984
+Title
+ Combined Association of Novel and Traditional Inflammatory Biomarkers With Carotid Artery Plaque: GlycA Versus C-Reactive Protein (ELSA-Brasil).
+Source
+ American Journal of Cardiology. 204:140-150, 2023 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tebar WR; Meneghini V; Goulart AC; Santos IS; Santos RD; Bittencourt MS; Generoso G; Pereira AC; Blaha MJ; Jones SR; Toth PP; Otvos JD; Lotufo PA; Bensenor IM
+Authors Full Name
+ Tebar, William R; Meneghini, Vandrize; Goulart, Alessandra C; Santos, Itamar S; Santos, Raul D; Bittencourt, Marcio S; Generoso, Giuliano; Pereira, Alexandre C; Blaha, Michael J; Jones, Steven R; Toth, Peter P; Otvos, James D; Lotufo, Paulo A; Bensenor, Isabela M.
+Institution
+ Tebar, William R. Center for Clinical and Epidemiological Research, University Hospital of University of Sao Paulo, Sao Paulo, Brazil.
+ Meneghini, Vandrize. Center for Clinical and Epidemiological Research, University Hospital of University of Sao Paulo, Sao Paulo, Brazil.
+ Goulart, Alessandra C. Center for Clinical and Epidemiological Research, University Hospital of University of Sao Paulo, Sao Paulo, Brazil.
+ Santos, Itamar S. Center for Clinical and Epidemiological Research, University Hospital of University of Sao Paulo, Sao Paulo, Brazil.
+ Santos, Raul D. Lipid Clinic of Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil.
+ Bittencourt, Marcio S. Center for Clinical and Epidemiological Research, University Hospital of University of Sao Paulo, Sao Paulo, Brazil.
+ Generoso, Giuliano. Center for Clinical and Epidemiological Research, University Hospital of University of Sao Paulo, Sao Paulo, Brazil.
+ Pereira, Alexandre C. Laboratory of Genetics and Molecular Cardiology, University of Sao Paulo Medical School Hospital, Sao Paulo, SP, Brazil.
+ Blaha, Michael J. Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland.
+ Jones, Steven R. Department of Preventive Cardiology, CGH Medical Center, Sterling, Illinois.
+ Toth, Peter P. Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland; Department of Preventive Cardiology, CGH Medical Center, Sterling, Illinois.
+ Otvos, James D. Laboratory Corporation of America Holdings (LabCorp), Morrisville, North Carolina.
+ Lotufo, Paulo A. Center for Clinical and Epidemiological Research, University Hospital of University of Sao Paulo, Sao Paulo, Brazil.
+ Bensenor, Isabela M. Center for Clinical and Epidemiological Research, University Hospital of University of Sao Paulo, Sao Paulo, Brazil. Electronic address: isabensenor@gmail.com.
+MeSH Subject Headings
+ Adult
+ Female
+ Humans
+ Middle Aged
+ Acetylation
+ Biomarkers
+ C-Reactive Protein/an [Analysis]
+ *C-Reactive Protein
+ *Carotid Stenosis
+ Cross-Sectional Studies
+ Glycoproteins
+ Inflammation
+ Obesity
+ Risk Factors
+ Male
+Abstract
+ Elevated levels of glycoprotein acetylation (GlycA) and C-reactive protein (CRP) have been associated with carotid artery plaque (CAP). However, it is not yet established if elevations in both inflammatory biomarkers provide incremental association with CAP. This study aimed evaluate the cross-sectional association of high CRP and GlycA with CAP at baseline participants from the ELSA-Brasil adult cohort. Participants with information on CRP, GlycA, and CAP with neither previous cardiovascular disease nor CRP >10 mg/L were included. High GlycA and CRP were defined as values within upper quintile and >3 mg/L, respectively. Participants were classified into 4 groups: 1. nonelevated CRP/GlycA (reference group); 2. elevated CRP alone; 3. elevated GlycA alone; and 4. both elevated. The analysis included 4,126 participants with median age of 50 years-old, being 54.2% of women. Prevalence of CAP was 36.1%. Participants with high CRP had the highest frequency of obesity, whereas participants with high GlycA presented higher cardiovascular risk factor burden and were more likely to have CAP than the reference group (odds ratio [OR] 1.39, 95% confidence interval [CI] 1.11 to 1.73), persisting after multivariable adjustment (OR 1.37, 95% CI 1.02 to 1.83). Participants with both elevated CRP and GlycA were more likely to have CAP in crude (OR 1.35, 95% CI 1.10 to 1.65) but not in adjusted models. The findings suggest potential different biologic pathways between inflammation and carotid atherosclerosis: high GlycA was associated with CAP whereas high CRP was more associated with obesity. Copyright © 2023 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). 0 (Glycoproteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.amjcard.2023.07.034
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tebar&issn=0002-9149&title=American+Journal+of+Cardiology&atitle=Combined+Association+of+Novel+and+Traditional+Inflammatory+Biomarkers+With+Carotid+Artery+Plaque%3A+GlycA+Versus+C-Reactive+Protein+%28ELSA-Brasil%29.&volume=204&issue=&spage=140&epage=150&date=2023&doi=10.1016%2Fj.amjcard.2023.07.034&pmid=37542984&sid=OVID:medline
+
+<198>
+Unique Identifier
+ 37524743
+Title
+ Temporal relationships between BMI and obesity-related predictors of cardiometabolic and breast cancer risk in a longitudinal cohort.
+Source
+ Scientific Reports. 13(1):12361, 2023 07 31.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xu B; Lv L; Chen X; Li X; Zhao X; Yang H; Feng W; Jiang X; Li J
+Authors Full Name
+ Xu, Bin; Lv, Liang; Chen, Xin; Li, Xingyue; Zhao, Xunying; Yang, Huifang; Feng, Wanting; Jiang, Xia; Li, Jiayuan.
+Institution
+ Xu, Bin. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, 16#, Section 3, Renmin Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Lv, Liang. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, 16#, Section 3, Renmin Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Chen, Xin. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, 16#, Section 3, Renmin Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Li, Xingyue. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, 16#, Section 3, Renmin Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Zhao, Xunying. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, 16#, Section 3, Renmin Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Yang, Huifang. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, 16#, Section 3, Renmin Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Feng, Wanting. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, 16#, Section 3, Renmin Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Jiang, Xia. Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
+ Li, Jiayuan. Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, 16#, Section 3, Renmin Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China. lijiayuan@scu.edu.cn.
+MeSH Subject Headings
+ Humans
+ Female
+ Breast Neoplasms/et [Etiology]
+ Breast Neoplasms/co [Complications]
+ *Breast Neoplasms
+ Body Mass Index
+ Longitudinal Studies
+ Prospective Studies
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Risk Factors
+ Biomarkers
+ Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases
+Abstract
+ Prospective inter-relationships among biomarkers were unexplored, which may provide mechanistic insights into diseases. We investigated the longitudinal associations of BMI change with trajectories of biomarkers related to cardiometabolic or breast cancer risk. A longitudinal study was conducted among 444 healthy women between 2019 to 2021. Cross-lagged path analysis was used to examine the temporal relationships among BMI, cardiometabolic risk score (CRS), and obesity-related proteins score (OPS) of breast cancer. Linear mixed-effect models were applied to investigate associations of time-varying BMI with biomarker-based risk score trajectories. Baseline BMI was associated with subsequent change of breast cancer predictors (P = 0.03), and baseline CRS were positively associated with OPS change (P < 0.001) but not vice versa. After fully adjustment of confounders, we found a 0.058 (95%CI = 0.009-0.107, P = 0.020) units increase of CRS and a 1.021 (95%CI = 0.041-1.995, P = 0.040) units increase of OPS as BMI increased 1 kg/m2 per year in postmenopausal women. OPS increased 0.784 (95%CI = 0.053-1.512, P = 0.035) units as CRS increased 1 unit per year. However, among premenopausal women, BMI only significantly affected CRS (beta = 0.057, 95%CI = 0.007 to 0.107, P = 0.025). No significant change of OPS with time-varying CRS was found. Higher increase rates of BMI were associated with worse trajectories of biomarker-based risk of cardiometabolic and breast cancer. The longitudinal impact of CRS on OPS is unidirectional. Recommendations such as weight control for the reduction of cardiometabolic risk factors may benefit breast cancer prevention, especially in postmenopausal women. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41598-023-39387-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xu&issn=2045-2322&title=Scientific+Reports&atitle=Temporal+relationships+between+BMI+and+obesity-related+predictors+of+cardiometabolic+and+breast+cancer+risk+in+a+longitudinal+cohort.&volume=13&issue=1&spage=12361&epage=&date=2023&doi=10.1038%2Fs41598-023-39387-w&pmid=37524743&sid=OVID:medline
+
+<199>
+Unique Identifier
+ 37516817
+Title
+ Preliminary evidence of glycine as a biomarker of cardiovascular disease risk in children with obesity.
+Source
+ International Journal of Obesity. 47(10):1023-1026, 2023 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ do Prado WL; Josephson S; Cosentino RG; Churilla JR; Hossain J; Balagopal PB
+Author NameID
+ Josephson, Samantha; ORCID: https://orcid.org/0000-0003-4480-1371
+ Balagopal, P Babu; ORCID: https://orcid.org/0000-0001-6940-0772
+Authors Full Name
+ do Prado, Wagner Luiz; Josephson, Samantha; Cosentino, Ralph G; Churilla, James R; Hossain, Jobayer; Balagopal, P Babu.
+Institution
+ do Prado, Wagner Luiz. California State University - San Bernardino, San Bernardino, CA, USA.
+ Josephson, Samantha. Biomedical Research, Nemours Children's Health System, Jacksonville, FL, USA.
+ Cosentino, Ralph G. Department of Kinesiology, University of North Florida, Jacksonville, FL, USA.
+ Churilla, James R. Department of Kinesiology, University of North Florida, Jacksonville, FL, USA.
+ Hossain, Jobayer. Department of Biostatistics, Nemours Children's Health System, Wilmington, DE, USA.
+ Balagopal, P Babu. Biomedical Research, Nemours Children's Health System, Jacksonville, FL, USA. babu.balagopal@nemours.org.
+ Balagopal, P Babu. Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN, USA. babu.balagopal@nemours.org.
+MeSH Subject Headings
+ Adult
+ Female
+ Humans
+ Male
+ Child
+ Adolescent
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Adiponectin
+ Interleukin-6
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ *Insulin Resistance
+ Biomarkers
+Abstract
+ Glycine (GLY) is a substrate for a wide range of metabolic processes. Several preclinical and adult studies demonstrated inverse associations of GLY with obesity, cardiovascular disease (CVD) and diabetes. However, little evidence is available on relationships between GLY and CVD risk in children. We assessed links between circulating GLY and biomarkers of CVD in children with obesity. Participants included both male and females with normal weight (NW, n = 6) and obesity (OB, n = 15), with age 14-18 years and Tanner stage >IV. Concentrations of GLY, branched chain amino acids (BCAA), and 25-hydroxy vitamin-D [25(OH)D], glucose, insulin, adiponectin, high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) were measured using established techniques, and body composition by DXA. Homeostatic model assessment for insulin resistance (HOMA-IR) was calculated. Our study identified major relationships of GLY (p-value < 0.01 for all) of GLY with visceral fat (r2 = 0.40), BCAA (r2 = 0.44), HOMA-IR (r2 = 0.33), 25(OH)D (r2 = 0.48), IL-6 (r2 = 0.46) and adiponectin (r2 = 0.39). Given that CVD progression is a continuum and the disease itself is not present in children and biomarkers are typically used to monitor CVD in children, the links between GLY and biomarkers of CVD provide evidence for the first time of a potential role for GLY in CVD in children with obesity. Copyright © 2023. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Interleukin-6). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41366-023-01354-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=do+Prado&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Preliminary+evidence+of+glycine+as+a+biomarker+of+cardiovascular+disease+risk+in+children+with+obesity.&volume=47&issue=10&spage=1023&epage=1026&date=2023&doi=10.1038%2Fs41366-023-01354-w&pmid=37516817&sid=OVID:medline
+
+<200>
+Unique Identifier
+ 37511388
+Title
+ Lipid Peroxidation as a Possible Factor Affecting Bone Resorption in Obese Subjects-Preliminary Research.
+Source
+ International Journal of Molecular Sciences. 24(14), 2023 Jul 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Maciejewski M; Siodmiak J; Borkowski B; Lorkowski M; Olszewska-Slonina DM
+Author NameID
+ Olszewska-Slonina, Dorota M; ORCID: https://orcid.org/0000-0001-9742-451X
+Authors Full Name
+ Maciejewski, Marcin; Siodmiak, Joanna; Borkowski, Bartlomiej; Lorkowski, Matthias; Olszewska-Slonina, Dorota M.
+Institution
+ Maciejewski, Marcin. Clinical Department of Orthopedics and Traumatology of the Musculoskeletal System, Antoni Jurasz University Hospital in Bydgoszcz, M. Curie-Sklodowskiej 9, 85-094 Bydgoszcz, Poland.
+ Siodmiak, Joanna. Department of Laboratory Diagnostics, Collegium Medicum, Nicolaus Copernicus University, M. Curie-Sklodowskiej 9, 85-094 Bydgoszcz, Poland.
+ Borkowski, Bartlomiej. Clinical Department of Orthopedics and Traumatology of the Musculoskeletal System, Antoni Jurasz University Hospital in Bydgoszcz, M. Curie-Sklodowskiej 9, 85-094 Bydgoszcz, Poland.
+ Lorkowski, Matthias. Clinical Department of Orthopedics and Traumatology of the Musculoskeletal System, Antoni Jurasz University Hospital in Bydgoszcz, M. Curie-Sklodowskiej 9, 85-094 Bydgoszcz, Poland.
+ Olszewska-Slonina, Dorota M. Department of Pathobiochemistry and Clinical Chemistry, Collegium Medicum, Nicolaus Copernicus University, M. Curie-Sklodowskiej 9, 85-094 Bydgoszcz, Poland.
+MeSH Subject Headings
+ Male
+ Humans
+ Female
+ Antioxidants/me [Metabolism]
+ *Antioxidants
+ Catalase/me [Metabolism]
+ Lipid Peroxidation
+ *Bone Resorption
+ Obesity/co [Complications]
+ Bone Remodeling/ph [Physiology]
+ Collagen Type I/me [Metabolism]
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ antioxidants
+ bone turnover markers
+ lipids
+ malondialdehyde
+ obesity
+ oxidative stress
+ peroxidation
+ vitamin A
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Oxidative stress, which promotes bone catabolism, also affects the quality of bone tissue. We aimed to assess the impact of metabolic disorders and oxidant-antioxidant imbalance associated with primary obesity on bone resorption and formation processes. Anthropometric parameters, metabolic variables, oxidative stress indicators (malondialdehyde, vitamins A and E, uric acid, superoxide dismutase, catalase, glutathione peroxidase, type 1 paraoxonase, iron-reducing plasma antioxidant power) and markers of bone turnover (type I procollagen N-terminal propeptide and the type I collagen C-terminal cross-linked telopeptide; P1NP and CTX) were assessed in 108 Polish participants. Under the influence of oxidative stress, both enzymatic and non-enzymatic defense mechanisms were stimulated in obese subjects, especially in women, who had increased lipid peroxidation and activity of catalase (particularly in first-degree obesity) and decreased vitamin E concentration. The process of lipid peroxidation, as well as the weakening of the bone formation, was strongly manifested in women at a BMI range of 35.0-39.9 kg/m2 but not at BMI > 40.0 kg/m2, but it had a comprehensive negative impact on bone turnover in obese men. Obesity and its degree of advancement significantly affected the decrease in the concentration of the marker of bone formation-P1NP-only in the plasma of women. Excessive body weight had no effect on the value of the bone resorption marker in plasma, regardless of gender. Our results confirm the existence of the "obesity paradox" in the aspect of bone tissue metabolism and suggest that a specific body weight threshold changed the molecular response of the tissue.
+Registry Number/Name of Substance
+ 0 (Antioxidants). EC 1-11-1-6 (Catalase). 0 (Procollagen Type I). 0 (Collagen Type I). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3390%2fijms241411629
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Maciejewski&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Lipid+Peroxidation+as+a+Possible+Factor+Affecting+Bone+Resorption+in+Obese+Subjects-Preliminary+Research.&volume=24&issue=14&spage=&epage=&date=2023&doi=10.3390%2Fijms241411629&pmid=37511388&sid=OVID:medline
+
+<201>
+Unique Identifier
+ 37511378
+Title
+ Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis.
+Source
+ International Journal of Molecular Sciences. 24(14), 2023 Jul 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gil-Martinez M; Lorente-Sorolla C; Rodrigo-Munoz JM; Naharro S; Garcia-de Castro Z; Sastre J; Valverde-Monge M; Quirce S; Caballero ML; Olaguibel JM; Del Pozo V
+Author NameID
+ Gil-Martinez, Marta; ORCID: https://orcid.org/0000-0002-2075-7874
+ Rodrigo-Munoz, Jose M; ORCID: https://orcid.org/0000-0003-3873-4563
+ Naharro, Sara; ORCID: https://orcid.org/0000-0002-6868-140X
+ Quirce, Santiago; ORCID: https://orcid.org/0000-0001-8086-0921
+ Caballero, Maria L; ORCID: https://orcid.org/0000-0002-9207-6445
+ Del Pozo, Victoria; ORCID: https://orcid.org/0000-0001-6228-1969
+Authors Full Name
+ Gil-Martinez, Marta; Lorente-Sorolla, Clara; Rodrigo-Munoz, Jose M; Naharro, Sara; Garcia-de Castro, Zahara; Sastre, Joaquin; Valverde-Monge, Marcela; Quirce, Santiago; Caballero, Maria L; Olaguibel, Jose M; Del Pozo, Victoria.
+Institution
+ Gil-Martinez, Marta. Immunoallergy Laboratory, Immunology Department, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain.
+ Gil-Martinez, Marta. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Lorente-Sorolla, Clara. Immunoallergy Laboratory, Immunology Department, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain.
+ Rodrigo-Munoz, Jose M. Immunoallergy Laboratory, Immunology Department, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain.
+ Rodrigo-Munoz, Jose M. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Naharro, Sara. Immunoallergy Laboratory, Immunology Department, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain.
+ Garcia-de Castro, Zahara. Immunoallergy Laboratory, Immunology Department, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain.
+ Sastre, Joaquin. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Sastre, Joaquin. Allergy Department, Hospital Universitario Fundacion Jimenez Diaz, 28040 Madrid, Spain.
+ Valverde-Monge, Marcela. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Valverde-Monge, Marcela. Allergy Department, Hospital Universitario Fundacion Jimenez Diaz, 28040 Madrid, Spain.
+ Quirce, Santiago. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Quirce, Santiago. Department of Allergy, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, Spain.
+ Caballero, Maria L. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Caballero, Maria L. Department of Allergy, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, Spain.
+ Olaguibel, Jose M. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Olaguibel, Jose M. Severe Asthma Unit, Department of Allergy, Hospital Universitario de Navarra, NavarraBiomed, 31008 Pamplona, Spain.
+ Del Pozo, Victoria. Immunoallergy Laboratory, Immunology Department, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain.
+ Del Pozo, Victoria. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Del Pozo, Victoria. Department of Medicine, Faculty of Medicine, Universidad Autonoma de Madrid (UAM), 28049 Madrid, Spain.
+MeSH Subject Headings
+ Humans
+ Asthma/co [Complications]
+ Asthma/ge [Genetics]
+ *Asthma
+ Biomarkers
+ Insulin-Like Growth Factor Binding Protein 3/ge [Genetics]
+ MicroRNAs/ge [Genetics]
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ *Obesity
+ Phenotype
+ Quality of Life
+Keyword Heading
+ IGF axis
+ asthma phenotypes/endotypes
+ biomarkers
+ eosinophilic asthma
+ obese asthma
+ serum microRNAs
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We previously demonstrated that hsa-miR-26a-1-3p and hsa-miR-376a-3p, biomarkers related to an inflammatory profile, discriminate eosinophilic from non-eosinophilic asthmatics. We aimed to study hsa-miR-26a-1-3p, hsa-miR-376a-3p, and their target genes in asthmatic subjects with or without obesity to find biomarkers and comprehend obese asthma mechanisms. Lung tissue samples were obtained from asthmatic patients (n = 16) and healthy subjects (n = 20). We measured miRNA expression using RT-qPCR and protein levels (IGF axis) by ELISA in confirmation samples from eosinophilic (n = 38) and non-eosinophilic (n = 39) obese (n = 26) and non-obese (n = 51) asthma patients. Asthmatic lungs showed higher hsa-miR-26a-1-3p and hsa-miR-376a-3p expression than healthy lungs. A study of seven genes regulated by these miRNAs revealed differential expression of IGFBP3 between asthma patients and healthy individuals. In obese asthma patients, we found higher hsa-miR-26a-1-3p and IGF-1R values and lower values for hsa-miR-376a-3p and IGFBP-3. Hsa-miR-26a-1-3p and IGFBP-3 were directly and inversely correlated with body mass index, respectively. Hsa-miR-26a-1-3p and hsa-miR-376a-3p could be used as biomarkers to phenotype patients with eosinophilic and non-eosinophilic asthma in relation to comorbid obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin-Like Growth Factor Binding Protein 3). 0 (MicroRNAs). 0 (MIRN376A1 microRNA, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3390%2fijms241411620
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gil-Martinez&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Obese+Asthma+Phenotype+Is+Associated+with+hsa-miR-26a-1-3p+and+hsa-miR-376a-3p+Modulating+the+IGF+Axis.&volume=24&issue=14&spage=&epage=&date=2023&doi=10.3390%2Fijms241411620&pmid=37511378&sid=OVID:medline
+
+<202>
+Unique Identifier
+ 37506863
+Title
+ Unravelling the anti-inflammatory and antioxidant effects of standardized green and black caffeinated coffee, tea, and their mixtures in an obese male rat model: Insights from biochemical, metabolomic, and histopathological analyses.
+Source
+ Food & Chemical Toxicology. 179:113971, 2023 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ El-Kersh DM; Kotob SE; Ammar NM; Mohawed OAM; Ahmed HH; Farag MA
+Authors Full Name
+ El-Kersh, Dina M; Kotob, Soheir E; Ammar, Naglaa M; Mohawed, Ola A M; Ahmed, Hanaa H; Farag, Mohamed A.
+Institution
+ El-Kersh, Dina M. Department of Pharmacognosy, Faculty of Pharmacy, The British University in Egypt, 11837, Cairo, Egypt. Electronic address: dina.elkersh@bue.edu.eg.
+ Kotob, Soheir E. Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.
+ Ammar, Naglaa M. Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.
+ Mohawed, Ola A M. Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.
+ Ahmed, Hanaa H. Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.
+ Farag, Mohamed A. Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St., 11562, Cairo, Egypt. Electronic address: Mohamed.farag@pharma.cu.edu.eg.
+MeSH Subject Headings
+ Rats
+ Male
+ Animals
+ Antioxidants/pd [Pharmacology]
+ *Antioxidants
+ *Coffee
+ Plant Extracts/pd [Pharmacology]
+ Obesity/me [Metabolism]
+ Tea/ae [Adverse Effects]
+ Anti-Inflammatory Agents/tu [Therapeutic Use]
+ Metabolomics
+ Biomarkers
+Keyword Heading
+ Biomarkers
+ Coffee and tea
+ GC-MS
+ Metabolomics
+ Obesity
+ Serum
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is one of the major metabolic syndrome risk factors upon which altered metabolic pathways follow. This study aimed to discern altered metabolic pathways associated with obesity and to pinpoint metabolite biomarkers in serum of obese rats fed on high fructose diet using metabolomics. Further, the effect of standardized green versus black caffeinated aqueous extracts (tea and coffee) in controlling obesity and its comorbidities through monitoring relevant serum biomarkers viz. Leptin, adiponectin, spexin, malondialdehyde, total antioxidant capacity. Liver tissue oxidative stress (catalase, super oxide dismutase and glutathione) and inflammation (IL-1beta and IL-6) markers were assessed for green coffee and its mixture with green tea. Results revealed improvement of all parameters upon treatments with more prominence for those treated with green caffeinated extract (coffee and tea) especially in mixture. Upon comparing with obese rat group, the green mixture of coffee and tea exhibited anti-hyperlipidemic action through lowering serum triglycerides by 35.0% and elevating high density lipoprotein by 71.0%. Black tea was likewise effective in lowering serum cholesterol and low density lipoprotein by 28.0 and 50.6%, respectively. GC-MS- based metabolomics of rat serum led to the identification of 34 metabolites with obese rat serum enriched in fatty acids (oleamide). Copyright © 2023 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Coffee). 0 (Plant Extracts). 0 (Tea). 0 (Anti-Inflammatory Agents). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.fct.2023.113971
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=El-Kersh&issn=0278-6915&title=Food+%26+Chemical+Toxicology&atitle=Unravelling+the+anti-inflammatory+and+antioxidant+effects+of+standardized+green+and+black+caffeinated+coffee%2C+tea%2C+and+their+mixtures+in+an+obese+male+rat+model%3A+Insights+from+biochemical%2C+metabolomic%2C+and+histopathological+analyses.&volume=179&issue=&spage=113971&epage=&date=2023&doi=10.1016%2Fj.fct.2023.113971&pmid=37506863&sid=OVID:medline
+
+<203>
+Unique Identifier
+ 37497846
+Title
+ The challenging role of micro-RNAs in non-alcoholic fatty liver disease in children with obesity: is it time for a new era?. [Review]
+Source
+ Expert review of gastroenterology & hepatology. 17(8):817-824, 2023 Jul-Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bartiromo M; Nardolillo M; Ferrara S; Russo G; Miraglia Del Giudice E; Di Sessa A
+Author NameID
+ Di Sessa, Anna; ORCID: https://orcid.org/0000-0002-5877-3757
+Authors Full Name
+ Bartiromo, Mario; Nardolillo, Michele; Ferrara, Serena; Russo, Giuseppina; Miraglia Del Giudice, Emanuele; Di Sessa, Anna.
+Institution
+ Bartiromo, Mario. Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Nardolillo, Michele. Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Ferrara, Serena. Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Russo, Giuseppina. Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Miraglia Del Giudice, Emanuele. Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Di Sessa, Anna. Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
+MeSH Subject Headings
+ Humans
+ Child
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ *Non-alcoholic Fatty Liver Disease
+ MicroRNAs/ge [Genetics]
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ Liver/pa [Pathology]
+ Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ Biomarkers
+ children
+ diagnosis
+ microRNAs
+ nonalcoholic fatty liver disease
+ obesity
+ treatment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: As the pediatric obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in childhood. Pediatric NAFLD pathophysiology is tangled and still unclear, but insulin resistance (IR), genetics, epigenetics, oxidative stress, and inflammation act as key players. Due to the increased cardiometabolic risk of these patients, several biomarkers have been proposed for early NAFLD identification, but their clinical utility is poor. Recently, hepatic dysregulation of microRNAs (miRNAs) has been linked to metabolic dysfunction, which in turn implied in NAFLD development. Evidence on the intriguing role of miRNAs in NAFLD pathogenesis has emerging especially in at-risk children such as those with obesity. However, pediatric evidence supporting their potential use as early noninvasive NAFLD tools is still limited but promising.
+
+ AREAS COVERED: We provided an overview on the emerging role of miRNAs in pediatric NAFLD by addressing some issues regarding their pathophysiological link with the metabolic milieu and their role as reliable NAFLD markers in children with obesity.
+
+ EXPERT OPINION: Strong evidence supports a potential role of miRNAs as early biomarkers of NAFLD in children with obesity. They might represent a valid diagnostic and targeted therapeutic tool due to its close pathogenic link with the metabolic milieu.
+Registry Number/Name of Substance
+ 0 (MicroRNAs). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1080%2f17474124.2023.2242245
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bartiromo&issn=1747-4124&title=Expert+review+of+gastroenterology+%26+hepatology&atitle=The+challenging+role+of+micro-RNAs+in+non-alcoholic+fatty+liver+disease+in+children+with+obesity%3A+is+it+time+for+a+new+era%3F.&volume=17&issue=8&spage=817&epage=824&date=2023&doi=10.1080%2F17474124.2023.2242245&pmid=37497846&sid=OVID:medline
+
+<204>
+Unique Identifier
+ 37497233
+Title
+ Identification of S100A8 as a common diagnostic biomarkers and exploring potential pathogenesis for osteoarthritis and metabolic syndrome.
+Source
+ Frontiers in Immunology. 14:1185275, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang X; Liu J; Huang W
+Authors Full Name
+ Huang, Xu; Liu, Jiacheng; Huang, Wei.
+Institution
+ Huang, Xu. Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
+ Liu, Jiacheng. Department of Orthopedics, Orthopedic Laboratory of Chongqing Medical University, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
+ Huang, Wei. Department of Orthopedics, Orthopedic Laboratory of Chongqing Medical University, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
+MeSH Subject Headings
+ Humans
+ Biomarkers
+ Calgranulin A/ge [Genetics]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ge [Genetics]
+ *Metabolic Syndrome
+ *Musculoskeletal Diseases
+ Obesity
+ Osteoarthritis/di [Diagnosis]
+ Osteoarthritis/ge [Genetics]
+ *Osteoarthritis
+Keyword Heading
+ GEO
+ S100A8
+ diagnostic biomarker
+ metabolic syndrome
+ osteoarthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Osteoarthritis (OA) is the most frequent musculoskeletal disease and the major contributor to disability worldwide. Metabolic syndrome (MetS) has been recognized as being associated with the pathogenesis of osteoarthritis. However, the exact mechanisms and links between the two are not clear.
+
+ Methods: We downloaded clinical information data and gene expression profiles for OA and MetS from the database of Gene Expression Omnibus (GEO), and immune related gene (IRG) from the database of Immunology Database and Analysis Portal (IMMPORT). After screening OA-DEG and MetS-DEG, we identified the common immune hub gene by screening the overlapping genes between OA-DEG, MetS-DEG and IRG. Then we conducted single-gene analysis of S100A8, assessed the correlation of S100A8 with immune cell infiltration, and verified the diagnostic value of S100A8 in OA and MetS database respectively.
+
+ Results: 323 OA-DEGs,101 MetS-DEGs and an immune-related hub gene, S100A8, were identified. In single gene analysis of S100A8 in OA samples, GSEA suggested that immune-related biological processes were more significantly enriched. The results of immune cell infiltration analysis showed that the enrichment fraction of M2 macrophages was significantly higher in the high S100A8-expressing group, and the level of S100A8 expression was positively correlated with M2 macrophage infiltration. The results of the dataset validation showed that S100A8 expression levels were significantly upregulated in the OA group and performed well in the diagnosis of OA. In single gene analysis of S100A8 in MetS samples, immune cell infiltration analysis showed that monocyte infiltration was higher in the S100A8 high expression samples and that there was a positive correlation between the two. Dataset validation showed that S100A8 is of high value for the diagnosis of MetS. In the validation of the dataset for the four metabolism-related diseases (obesity, diabetes, hypertension and hyperlipidaemia), S100A8 was expressed at higher levels in the disease group and also had a higher diagnostic value for the four metabolism-related diseases.
+
+ Conclusion: S100A8 is a common hub gene and diagnostic biomarker for OA and MetS, and the immune regulation involved in S100A8 may play a central role in the pathogenesis of OA and MetS. Copyright © 2023 Huang, Liu and Huang.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Calgranulin A). 0 (S100A8 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.3389%2ffimmu.2023.1185275
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Identification+of+S100A8+as+a+common+diagnostic+biomarkers+and+exploring+potential+pathogenesis+for+osteoarthritis+and+metabolic+syndrome.&volume=14&issue=&spage=1185275&epage=&date=2023&doi=10.3389%2Ffimmu.2023.1185275&pmid=37497233&sid=OVID:medline
+
+<205>
+Unique Identifier
+ 37494765
+Title
+ Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females: Implication of menopause and ageing.
+Source
+ Prostaglandins Leukotrienes & Essential Fatty Acids. 195:102581, 2023 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sousa S; Pestana D; Faria G; Delerue-Matos C; Calhau C; Fernandes Domingues V
+Authors Full Name
+ Sousa, Sara; Pestana, Diogo; Faria, Gil; Delerue-Matos, Cristina; Calhau, Conceicao; Fernandes Domingues, Valentina.
+Institution
+ Sousa, Sara. REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. Antonio Bernardino de Almeida 431, 4249-015 Porto, Portugal; Center for Research in Health Technologies and Information Systems, Rua Dr. Placido da Costa, 4200-450 Porto, Portugal.
+ Pestana, Diogo. Center for Research in Health Technologies and Information Systems, Rua Dr. Placido da Costa, 4200-450 Porto, Portugal; Nutricao e Metabolismo NOVA Medical School Faculdade de Ciencias Medicas Universidade Nova de Lisboa, Campo dos Martires da Patria 130, 1169-056 Lisboa, Portugal.
+ Faria, Gil. Center for Research in Health Technologies and Information Systems, Rua Dr. Placido da Costa, 4200-450 Porto, Portugal; Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.
+ Delerue-Matos, Cristina. REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. Antonio Bernardino de Almeida 431, 4249-015 Porto, Portugal.
+ Calhau, Conceicao. Center for Research in Health Technologies and Information Systems, Rua Dr. Placido da Costa, 4200-450 Porto, Portugal; Nutricao e Metabolismo NOVA Medical School Faculdade de Ciencias Medicas Universidade Nova de Lisboa, Campo dos Martires da Patria 130, 1169-056 Lisboa, Portugal.
+ Fernandes Domingues, Valentina. REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. Antonio Bernardino de Almeida 431, 4249-015 Porto, Portugal. Electronic address: vfd@isep.ipp.pt.
+MeSH Subject Headings
+ Female
+ Humans
+ Fatty Acids/me [Metabolism]
+ *Fatty Acids
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue
+ Obesity/me [Metabolism]
+ Menopause
+ Aging
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ Adipocytes
+ Biochemical parameters
+ Lipid
+ Metabolism
+ Obesity
+ Women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Fatty acids (FA) are biomarkers of metabolic dysfunction. Adipose tissue is the largest reservoir of FA and acts differently in obese individuals. Menopause by itself significantly alters metabolism, lipid metabolism dysregulation, and adipose tissue distribution. How adipose tissue FA alters an obese individual's metabolism depending on a female's menopausal status is yet poorly understood. Hence, the subcutaneous (scAT) and visceral adipose tissue (vAT) FA profile for 173 obese premenopausal and postmenopausal women was measured and associated with biochemical parameters. scAT and vAT FA profiles were distinct by themselves and in menopause. In total 816 associations were found with biochemical parameters, where only 58 were independent of the menopausal status. The associations found to emphasize the importance of assessing the adipose tissue FA profile and how their behavior changes with menopause. The FA are crucial in metabolic processes and can be helpful biomarkers in the prevention/treatment and follow-up of female obesity. Copyright © 2023 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Fatty Acids). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.plefa.2023.102581
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sousa&issn=0952-3278&title=Prostaglandins+Leukotrienes+%26+Essential+Fatty+Acids&atitle=Adipose+tissue+fatty+acids+as+biomarkers+for+metabolic+dysfunction+in+obese+females%3A+Implication+of+menopause+and+ageing.&volume=195&issue=&spage=102581&epage=&date=2023&doi=10.1016%2Fj.plefa.2023.102581&pmid=37494765&sid=OVID:medline
+
+<206>
+Unique Identifier
+ 37474543
+Title
+ Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications.
+Source
+ Scientific Reports. 13(1):11729, 2023 07 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bellot PENR; Braga ES; Omage FB; da Silva Nunes FL; Lima SCVC; Lyra CO; Marchioni DML; Pedrosa LFC; Barbosa F Jr; Tasic L; Sena-Evangelista KCM
+Authors Full Name
+ Bellot, Paula Emilia Nunes Ribeiro; Braga, Erik Sobrinho; Omage, Folorunsho Bright; da Silva Nunes, Francisca Leide; Lima, Severina Carla Vieira Cunha; Lyra, Clelia Oliveira; Marchioni, Dirce Maria Lobo; Pedrosa, Lucia Fatima Campos; Barbosa, Fernando Jr; Tasic, Ljubica; Sena-Evangelista, Karine Cavalcanti Mauricio.
+Institution
+ Bellot, Paula Emilia Nunes Ribeiro. Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
+ Braga, Erik Sobrinho. Biological Chemistry Laboratory, Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
+ Omage, Folorunsho Bright. Biological Chemistry Laboratory, Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
+ Omage, Folorunsho Bright. Computational Biology Research Group, Embrapa Agricultural Informatics, Campinas, Sao Paulo, Brazil.
+ da Silva Nunes, Francisca Leide. Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
+ Lima, Severina Carla Vieira Cunha. Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
+ Lyra, Clelia Oliveira. Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
+ Marchioni, Dirce Maria Lobo. Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo Campus, Sao Paulo, SP, Brazil.
+ Pedrosa, Lucia Fatima Campos. Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
+ Barbosa, Fernando Jr. Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirao Preto of the University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
+ Tasic, Ljubica. Biological Chemistry Laboratory, Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
+ Sena-Evangelista, Karine Cavalcanti Mauricio. Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. karine.sena@ufrn.br.
+MeSH Subject Headings
+ Adult
+ Humans
+ Aged
+ Cross-Sectional Studies
+ *Obesity
+ *Insulin Resistance
+ Cholesterol
+ Biomarkers
+ Triglycerides
+ Body Mass Index
+Abstract
+ Lipidomics studies have indicated an association between obesity and lipid metabolism dysfunction. This study aimed to evaluate and compare cardiometabolic risk factors, and the lipidomic profile in adults and older people. A cross-sectional study was conducted with 72 individuals, divided into two sex and age-matched groups: obese (body mass index-BMI >= 30 kg/m2; n = 36) and non-obese (BMI < 30 kg/m2; n = 36). The lipidomic profiles were evaluated in plasma using 1H nuclear magnetic resonance (1H-NMR) spectroscopy. Obese individuals had higher waist circumference (p < 0.001), visceral adiposity index (p = 0.029), homeostatic model assessment insulin resistance (HOMA-IR) (p = 0.010), and triacylglycerols (TAG) levels (p = 0.018). 1H-NMR analysis identified higher amounts of saturated lipid metabolite fragments, lower levels of unsaturated lipids, and some phosphatidylcholine species in the obese group. Two powerful machine learning (ML) models-k-nearest neighbors (kNN) and XGBoost (XGB) were employed to characterize the lipidomic profile of obese individuals. The results revealed metabolic alterations associated with obesity in the NMR signals. The models achieved high accuracy of 86% and 81%, respectively. The feature importance analysis identified signal at 1.50-1.60 ppm (-CO-CH2-CH2-, Cholesterol and fatty acid in TAG, Phospholipids) to have the highest importance in the two models. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 97C5T2UQ7J (Cholesterol). 0 (Biomarkers). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1038%2fs41598-023-38703-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bellot&issn=2045-2322&title=Scientific+Reports&atitle=Plasma+lipid+metabolites+as+potential+biomarkers+for+identifying+individuals+at+risk+of+obesity-induced+metabolic+complications.&volume=13&issue=1&spage=11729&epage=&date=2023&doi=10.1038%2Fs41598-023-38703-8&pmid=37474543&sid=OVID:medline
+
+<207>
+Unique Identifier
+ 37466621
+Title
+ Association between Arterial Hypertension and Laboratory Markers, Body Composition, Obstructive Sleep Apnea and Autonomic Parameters in Obese Patients.
+Original Title
+ Associacao entre Hipertensao Arterial Sistemica com Marcadores Laboratoriais, Composicao Corporal, Apneia Obstrutiva do Sono e Variabilidade da Frequencia Cardiaca em Adultos Obesos.
+Source
+ Arquivos Brasileiros de Cardiologia. 120(7):e20220728, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Santos CPC; Lagares LS; Santos SRM; Silva MSP; Macedo RC; Almeida LAB; Bomfim ES
+Author NameID
+ Santos, Clarcson Placido Conceicao; ORCID: https://orcid.org/0000-0001-7598-3775
+ Santos, Sarah Rafaela Mascarenhas; ORCID: https://orcid.org/0000-0002-9151-5549
+ Silva, Mariana Sousa de Pina; ORCID: https://orcid.org/0000-0001-5119-6638
+ Bomfim, Eric Simas; ORCID: https://orcid.org/0000-0001-9198-2318
+Authors Full Name
+ Santos, Clarcson Placido Conceicao; Lagares, Laura Souza; Santos, Sarah Rafaela Mascarenhas; Silva, Mariana Sousa de Pina; Macedo, Rodrigo Colares de; Almeida, Luiz Alberto Bastos de; Bomfim, Eric Simas.
+Institution
+ Santos, Clarcson Placido Conceicao. Escola Bahiana de Medicina e Saude Publica - Grupo de Pesquisa em Doencas Metabolicas, Exercicio Fisico e Tecnologias em Saude, Salvador, BA - Brasil.
+ Lagares, Laura Souza. Escola Bahiana de Medicina e Saude Publica - Grupo de Pesquisa em Doencas Metabolicas, Exercicio Fisico e Tecnologias em Saude, Salvador, BA - Brasil.
+ Santos, Sarah Rafaela Mascarenhas. Escola Bahiana de Medicina e Saude Publica - Grupo de Pesquisa em Doencas Metabolicas, Exercicio Fisico e Tecnologias em Saude, Salvador, BA - Brasil.
+ Silva, Mariana Sousa de Pina. Escola Bahiana de Medicina e Saude Publica - Grupo de Pesquisa em Doencas Metabolicas, Exercicio Fisico e Tecnologias em Saude, Salvador, BA - Brasil.
+ Macedo, Rodrigo Colares de. Escola Bahiana de Medicina e Saude Publica - Grupo de Pesquisa em Doencas Metabolicas, Exercicio Fisico e Tecnologias em Saude, Salvador, BA - Brasil.
+ Almeida, Luiz Alberto Bastos de. Universidade Estadual de Feira de Santana - Departamento de Educacao Fisica, Feira de Santana, BA - Brasil.
+ Bomfim, Eric Simas. Escola Bahiana de Medicina e Saude Publica - Grupo de Pesquisa em Doencas Metabolicas, Exercicio Fisico e Tecnologias em Saude, Salvador, BA - Brasil.
+MeSH Subject Headings
+ Humans
+ Female
+ Adult
+ Middle Aged
+ Male
+ Blood Glucose/an [Analysis]
+ Cross-Sectional Studies
+ *Hypertension
+ Sleep Apnea, Obstructive/co [Complications]
+ *Sleep Apnea, Obstructive
+ Obesity/co [Complications]
+ Body Composition
+ Biomarkers
+Abstract
+ BACKGROUND: Systemic arterial hypertension (SAH) is a multifactorial disease, highly prevalent and associated with health risks.
+
+ OBJECTIVE: The purpose of this study was to investigate the association between SAH and laboratory, anthropometric, heart rate variability (HRV), and obstructive sleep apnea markers and, secondarily, to analyze the sensitivity and specificity of the variables that are independent factors in the association.
+
+ METHODS: Cross-sectional study with 95 obese patients treated at an obesity referral clinic in Salvador, BA, Brazil. SAH data were obtained from electronic medical records. The sample was stratified in the Normotensive Group (NG) and the Hypertensive Group (HG), and laboratory markers, body composition, polysomnography, and HRV were measured to evaluate the association of SAH with the predictor variables. For the analysis, p<0.05 was adopted.
+
+ RESULTS: The average age of the NG was 36.3 +/- 10.1 and HG 40.4 +/- 10.6 years; 73.7% were women in the NG and 57.9% in HG; 82.4% in HG had insulin resistance. In the multivarious logistics regression model with adjustments in age, sex, height, and oxyhemoglobin saturation, SAH was inversely associated with fasting plasma glucose mg/dL (odds ratio [OR] = 0.96; 95% confidence interval [CI] = 0.92-0.99) and visceral fat area (VFA) cm2(OR = 0.98; 95% CI = 0.97-0.99). The area under the VFA curve was 0.728; CI 95% (0.620-0.836); fasting plasma glucose 0.693;CI 95% (0.582-0.804).
+
+ CONCLUSIONS: Lower VFA and fasting plasma glucose concentrations were inversely associated with SAH. In addition, fasting plasma glucose and VFA showed a high sensitivity for SAH screening.
+Other Abstract
+ Publisher
+ FUNDAMENTO: A hipertensao arterial sistemica (HAS) e uma doenca multifatorial, altamente prevalente e associada a riscos a saude.
+ OBJETIVO: O objetivo deste estudo foi investigar a associacao entre HAS e marcadores laboratoriais, antropometricos, de variabilidade da frequencia cardiaca (VFC) e de apneia obstrutiva do sono e, em segundo plano, analisar a sensibilidade e especificidade das variaveis que sao fatores independentes na associacao.
+ METODOS: Estudo transversal com 95 pacientes obesos atendidos em um ambulatorio de referencia em obesidade em Salvador, BA, Brasil. Os dados da HAS foram obtidos dos prontuarios eletronicos. A amostra foi estratificada em Grupo Normotenso (GN) e Grupo Hipertenso (GH), sendo medidos marcadores laboratoriais, composicao corporal, polissonografia e VFC para avaliar a associacao da HAS com as variaveis preditoras. Para as analises, adotou-se p<0,05.
+ RESULTADOS: A media da idade do GN foi de 36,3 +/- 10,1 e GH 40,4 +/- 10,6 anos, 73,7% eram mulheres no GN e 57,9% no GH; 82,4% no GH apresentavam resistencia a insulina. No modelo de regressao logistica multivariado com ajustes para idade, sexo, altura e saturacao de oxi-hemoglobina, a HAS foi inversamente associada a glicose plasmatica em jejum mg/dL (odds ratio [OR] = 0,96; intervalo de confianca de 95% [IC] = 0,92-0,99) e area de gordura visceral (AGV) cm2 (OR = 0,98; IC 95% = 0,97-0,99). A area sob a curva AGV foi de 0,728; IC 95% (0,620-0,836) e glicemia de jejum 0,693; IC 95% (0,582-0,804).
+ CONCLUSAO: Menores concentracoes de AGV e glicemia de jejum foram inversamente associadas a HAS. Alem disso, tanto a glicemia de jejum quanto o AGV mostraram alta sensibilidade para triagem de HAS.
+ Language: Portuguese
+Registry Number/Name of Substance
+ 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.36660%2fabc.20220728
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Santos&issn=0066-782X&title=Arquivos+Brasileiros+de+Cardiologia&atitle=Associacao+entre+Hipertensao+Arterial+Sistemica+com+Marcadores+Laboratoriais%2C+Composicao+Corporal%2C+Apneia+Obstrutiva+do+Sono+e+Variabilidade+da+Frequencia+Cardiaca+em+Adultos+Obesos.&volume=120&issue=7&spage=e20220728&epage=&date=2023&doi=10.36660%2Fabc.20220728&pmid=37466621&sid=OVID:medline
+
+<208>
+Unique Identifier
+ 37429525
+Title
+ Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes.
+Source
+ Molecular Metabolism. 75:101774, 2023 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ouni M; Eichelmann F; Jahnert M; Krause C; Saussenthaler S; Ott C; Gottmann P; Speckmann T; Huypens P; Wolter S; Mann O; De Angelis MH; Beckers J; Kirchner H; Schulze MB; Schurmann A
+Authors Full Name
+ Ouni, Meriem; Eichelmann, Fabian; Jahnert, Markus; Krause, Christin; Saussenthaler, Sophie; Ott, Christiane; Gottmann, Pascal; Speckmann, Thilo; Huypens, Peter; Wolter, Stefan; Mann, Oliver; De Angelis, Martin Hrabe; Beckers, Johannes; Kirchner, Henriette; Schulze, Matthias B; Schurmann, Annette.
+Institution
+ Ouni, Meriem. German Institute of Human Nutrition, Department of Experimental Diabetology, Potsdam-Rehbruecke, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Eichelmann, Fabian. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; German Institute of Human Nutrition, Department of Molecular Epidemiology, Potsdam-Rehbruecke, Germany.
+ Jahnert, Markus. German Institute of Human Nutrition, Department of Experimental Diabetology, Potsdam-Rehbruecke, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Krause, Christin. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute for Human Genetics, Section Epigenetics & Metabolism, University of Lubeck, Germany; Center of Brain, Behavior and Metabolism (CBBM), University of Lubeck, Germany.
+ Saussenthaler, Sophie. German Institute of Human Nutrition, Department of Experimental Diabetology, Potsdam-Rehbruecke, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Ott, Christiane. German Institute of Human Nutrition, Department of Molecular Toxicology, Potsdam-Rehbruecke, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.
+ Gottmann, Pascal. German Institute of Human Nutrition, Department of Experimental Diabetology, Potsdam-Rehbruecke, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Speckmann, Thilo. German Institute of Human Nutrition, Department of Experimental Diabetology, Potsdam-Rehbruecke, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Huypens, Peter. Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Wolter, Stefan. Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
+ Mann, Oliver. Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
+ De Angelis, Martin Hrabe. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany; School of Life Sciences, Chair of Experimental Genetics, Technical University Munich, Freising, Germany.
+ Beckers, Johannes. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; School of Life Sciences, Chair of Experimental Genetics, Technical University Munich, Freising, Germany.
+ Kirchner, Henriette. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute for Human Genetics, Section Epigenetics & Metabolism, University of Lubeck, Germany; Center of Brain, Behavior and Metabolism (CBBM), University of Lubeck, Germany.
+ Schulze, Matthias B. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; German Institute of Human Nutrition, Department of Molecular Epidemiology, Potsdam-Rehbruecke, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
+ Schurmann, Annette. German Institute of Human Nutrition, Department of Experimental Diabetology, Potsdam-Rehbruecke, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany. Electronic address: schuermann@dife.de.
+MeSH Subject Headings
+ Humans
+ Female
+ Mice
+ Animals
+ Hepcidins/ge [Genetics]
+ Hepcidins/me [Metabolism]
+ *Hepcidins
+ DNA Methylation
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Prospective Studies
+ Insulin/me [Metabolism]
+ Obesity/ge [Genetics]
+ Biomarkers/me [Metabolism]
+ Blood Cells/me [Metabolism]
+Keyword Heading
+ EPIC-Potsdam
+ Epigenetic markers
+ Hepcidin
+ T2D risk
+ Translational approach
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Better disease management can be achieved with earlier detection through robust, sensitive, and easily accessible biomarkers. The aim of the current study was to identify novel epigenetic biomarkers determining the risk of type 2 diabetes (T2D).
+
+ METHODS: Livers of 10-week-old female New Zealand Obese (NZO) mice, slightly differing in their degree of hyperglycemia and liver fat content and thereby in their diabetes susceptibility were used for expression and methylation profiling. We screened for differences in hepatic expression and DNA methylation in diabetes-prone and -resistant mice, and verified a candidate (HAMP) in human livers and blood cells. Hamp expression was manipulated in primary hepatocytes and insulin-stimulated pAKT was detected. Luciferase reporter assays were conducted in a murine liver cell line to test the impact of DNA methylation on promoter activity.
+
+ RESULTS: In livers of NZO mice, the overlap of methylome and transcriptome analyses revealed a potential transcriptional dysregulation of 12 hepatokines. The strongest effect with a 52% decreased expression in livers of diabetes-prone mice was detected for the Hamp gene, mediated by elevated DNA methylation of two CpG sites located in the promoter. Hamp encodes the iron-regulatory hormone hepcidin, which had a lower abundance in the livers of mice prone to developing diabetes. Suppression of Hamp reduces the levels of pAKT in insulin-treated hepatocytes. In liver biopsies of obese insulin-resistant women, HAMP expression was significantly downregulated along with increased DNA methylation of a homologous CpG site. In blood cells of incident T2D cases from the prospective EPIC-Potsdam cohort, higher DNA methylation of two CpG sites was related to increased risk of incident diabetes.
+
+ CONCLUSIONS: We identified epigenetic changes in the HAMP gene which may be used as an early marker preceding T2D. Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Hepcidins). 0 (Insulin). 0 (Biomarkers). 0 (HAMP protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.molmet.2023.101774
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ouni&issn=2212-8778&title=Molecular+Metabolism&atitle=Differences+in+DNA+methylation+of+HAMP+in+blood+cells+predicts+the+development+of+type+2+diabetes.&volume=75&issue=&spage=101774&epage=&date=2023&doi=10.1016%2Fj.molmet.2023.101774&pmid=37429525&sid=OVID:medline
+
+<209>
+Unique Identifier
+ 37424169
+Title
+ Effect of synbiotics on weight loss and metabolic health in adults with overweight and obesity: A randomized controlled trial.
+Source
+ Obesity. 31(8):2009-2020, 2023 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lyon J 3rd; Connell M; Chandrasekaran K; Srivastava S
+Author NameID
+ Srivastava, Shalini; ORCID: https://orcid.org/0000-0001-8497-5929
+Authors Full Name
+ Lyon, John 3rd; Connell, Mary; Chandrasekaran, Kartik; Srivastava, Shalini.
+Institution
+ Lyon, John 3rd. Product Development Department, Veyl Ventures-DBA Netbus Inc., New York, New York, USA.
+ Connell, Mary. Research Department, Veyl Ventures-DBA Netbus Inc., New York, New York, USA.
+ Chandrasekaran, Kartik. Supply Chain Department, Veyl Ventures-DBA Netbus Inc., New York, New York, USA.
+ Srivastava, Shalini. Clinical Development Department, Vedic Lifesciences Pvt. Ltd., Mumbai, Maharashtra, India.
+MeSH Subject Headings
+ Humans
+ Adult
+ Overweight/th [Therapy]
+ Overweight/me [Metabolism]
+ *Overweight
+ *Synbiotics
+ Quality of Life
+ Biomarkers
+ Obesity/th [Therapy]
+ Double-Blind Method
+ Weight Loss
+Abstract
+ OBJECTIVE: The study aimed to investigate the effect of synbiotics on body composition and metabolic health in individuals with excessive body weight.
+
+ METHODS: The 12-week randomized, double-blind, placebo-controlled clinical trial had individuals aged 30 to 60 years with BMI of 25 to 34.9 kg/m2 . In total, 172 participants were randomly allocated to either synbiotic V5 or V7 groups or the placebo group. The primary outcome was change in BMI and body fat percentage. Secondary outcomes were changes in weight, other metabolic health and inflammatory markers, gastrointestinal quality of life, and eating behaviors.
+
+ RESULTS: The V5 and V7 groups had a significant reduction in BMI (p < 0.0001) from baseline to the end of the study, as opposed to the nonsignificant change in the placebo group (p = 0.0711). This reduction in the V5 and V7 groups was statistically significant when compared individually with the change in the placebo group (p < 0.0001). This corresponded well with the decrease in body weight with V5 and V7 (p < 0.0001). In addition, compared with placebo, the increase in high-density lipoprotein was statistically significant in the V5 (p < 0.0001) and V7 groups (p = 0.0205). A similar trend was observed in the high-sensitivity C-reactive protein levels, with a statistically significant decrease in the V5 (p < 0.0001) and V7 (0.0005) groups.
+
+ CONCLUSIONS: The study demonstrates that synbiotic V5 and V7 were effective in reducing body weight in individuals with lifestyle modification. Copyright © 2023 The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1002%2foby.23801
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lyon&issn=1930-7381&title=Obesity&atitle=Effect+of+synbiotics+on+weight+loss+and+metabolic+health+in+adults+with+overweight+and+obesity%3A+A+randomized+controlled+trial.&volume=31&issue=8&spage=2009&epage=2020&date=2023&doi=10.1002%2Foby.23801&pmid=37424169&sid=OVID:medline
+
+<210>
+Unique Identifier
+ 37407189
+Title
+ Longer anogenital distance in female fetus of diabetic and obese pregnant women.
+Source
+ Taiwanese Journal of Obstetrics & Gynecology. 62(4):530-536, 2023 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Halici-Ozturk F; Yucel Yetiskin FD; Gurlek B; Ocal FD; Yakut K; Engin-Ustun Y; Celen S; Sahin D
+Authors Full Name
+ Halici-Ozturk, Filiz; Yucel Yetiskin, Fatma Didem; Gurlek, Beril; Ocal, Fatma Doga; Yakut, Kadriye; Engin-Ustun, Yaprak; Celen, Sevki; Sahin, Dilek.
+Institution
+ Halici-Ozturk, Filiz. Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, 06800, Ankara, Turkey. Electronic address: ozturkfh@gmail.com.
+ Yucel Yetiskin, Fatma Didem. Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, 06800, Ankara, Turkey.
+ Gurlek, Beril. Department of Obstetrics and Gynecology, Faculty of Medicine, Recep Tayyip Erdogan University, 53200, Rize, Turkey.
+ Ocal, Fatma Doga. Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, 06800, Ankara, Turkey.
+ Yakut, Kadriye. Etlik Zubeyde Hanim Women Health Care Training and Research Hospital, Obstetrics and Gynecology Department, 06010, Ankara, Turkey.
+ Engin-Ustun, Yaprak. Etlik Zubeyde Hanim Women Health Care Training and Research Hospital, Obstetrics and Gynecology Department, 06010, Ankara, Turkey.
+ Celen, Sevki. Etlik Zubeyde Hanim Women Health Care Training and Research Hospital, Obstetrics and Gynecology Department, 06010, Ankara, Turkey.
+ Sahin, Dilek. Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, 06800, Ankara, Turkey.
+MeSH Subject Headings
+ Pregnancy
+ Humans
+ Female
+ *Pregnant Women
+ Androgens
+ Prospective Studies
+ Genitalia, Female/dg [Diagnostic Imaging]
+ Obesity/co [Complications]
+ *Diabetes, Gestational
+ Biomarkers
+ Fetus
+ Anal Canal/dg [Diagnostic Imaging]
+Keyword Heading
+ Anogenital distance
+ Hyperandrogenism
+ Maternal diabetes
+ Maternal obesity
+ Prenatal ultrasound
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Previous studies revealed that prenatal exposure to androgen excess such as polycystic ovary syndrome (PCOS) is associated with offspring's anogenital distance (AGD) length, and AGD is a biomarker of intrauterine androgen exposure. This study aims to investigate a possible relationship of fetal AGD with maternal diabetes and obesity, and to evaluate whether AGD predicts the fetal androgen exposure related to diabetes and obesity in female fetus. This study is the first to focus on the relationship between offspring's AGD and maternal diabetes and obesity.
+
+ MATERIALS AND METHODS: This is a prospective study investigating 218 pregnant women (125 in control group and 93 in study group). Fetal AGD was measured from the center of anus to the posterior convergence of the fourchette by ultrasound. Multivariate linear regression analysis was applied to assess the association of the fetal AGD length with maternal diabetes and obesity.
+
+ RESULTS: The control patients had significantly shorter fetal AGD (mean:10.7 mm, P < 0.001) compared to diabetic, obese and diabetic obese patients (mean: 12.6 mm, 12.8 mm and 12.9 mm, respectively). The results of regression analysis showed that both maternal diabetes and obesity were significantly correlated with longer AGD in female fetus. The results confirmed also that offspring's AGD measurement in utero by ultrasound is feasible and reliable.
+
+ CONCLUSION: The study findings suggest that both maternal diabetes and obesity are associated with intrauterine androgenic milieu during pregnancy, and fetal AGD may be used as a biomarker to predict this effect. This may provide important advantages in terms of early detection of reproductive system abnormalities related to prenatal androgen exposure. Copyright © 2023. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Androgens). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.tjog.2023.02.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Halici-Ozturk&issn=1028-4559&title=Taiwanese+Journal+of+Obstetrics+%26+Gynecology&atitle=Longer+anogenital+distance+in+female+fetus+of+diabetic+and+obese+pregnant+women.&volume=62&issue=4&spage=530&epage=536&date=2023&doi=10.1016%2Fj.tjog.2023.02.005&pmid=37407189&sid=OVID:medline
+
+<211>
+Unique Identifier
+ 37400734
+Title
+ Glucose-dependent inflammatory responses in obese compared to lean individuals.
+Source
+ Endocrine. 81(3):464-476, 2023 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lundqvist MH; Pereira MJ; Eriksson JW
+Author NameID
+ Lundqvist, Martin H; ORCID: https://orcid.org/0000-0001-9348-4603
+ Pereira, Maria J; ORCID: https://orcid.org/0000-0001-5498-3899
+ Eriksson, Jan W; ORCID: https://orcid.org/0000-0002-2639-9481
+Authors Full Name
+ Lundqvist, Martin H; Pereira, Maria J; Eriksson, Jan W.
+Institution
+ Lundqvist, Martin H. Clinical Diabetology and Metabolism, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. martin.lundqvist@medsci.uu.se.
+ Pereira, Maria J. Clinical Diabetology and Metabolism, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
+MeSH Subject Headings
+ Humans
+ Glucose
+ *Insulin Resistance
+ Blood Glucose/me [Metabolism]
+ Insulin
+ *Diabetes Mellitus, Type 2
+ Vascular Endothelial Growth Factor A
+ Glucose Clamp Technique
+ Hyperglycemia/me [Metabolism]
+ *Hyperglycemia
+ *Hyperinsulinism
+ Obesity/co [Complications]
+ *Hypoglycemia
+ Biomarkers
+ Antigens, Neoplasm
+ Cell Adhesion Molecules
+Keyword Heading
+ Hyperglycemia
+ Hypoglycemia
+ Inflammation
+ Insulin resistance
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Obesity is characterized by chronic inflammation that may contribute to insulin resistance and promote type 2 diabetes. We have investigated whether inflammatory responses to glycemic and insulinemic variations are altered in obese individuals.
+
+ METHODS: Eight obese and eight lean individuals without diabetes had undergone hyperinsulinemic-euglycemic-hypoglycemic and hyperglycemic clamps in a previous study. Using Proximity Extension Assay, 92 inflammatory markers were analyzed from plasma samples at fasting, hyperinsulinemia-euglycemia, hypoglycemia and hyperglycemia.
+
+ RESULTS: In all participants, hyperinsulinemia, hypoglycemia and hyperglycemia led to reductions of 11, 19 and 62 out of the 70 fully evaluable biomarkers, respectively. FGF-21 increased during both hypoglycemia and hyperglycemia while IL-6 and IL-10 increased during hypoglycemia. In obese vs lean participants, Oncostatin-M, Caspase-8 and 4E-BP1 were more markedly suppressed during hypoglycemia, whereas VEGF-A was more markedly suppressed during hyperglycemia. BMI correlated inversely with changes of PD-L1 and CD40 during hyperinsulinemia, Oncostatin-M, TNFSF14, FGF-21 and 4EBP-1 during hypoglycemia and CCL23, VEGF-A and CDCP1 during hyperglycemia (Rho <= -0.50). HbA1c correlated positively with changes of MCP-2 and IL-15-RA during hyperinsulinemia (Rho >= 0.51) and inversely with changes of CXCL1, MMP-1 and Axin-1 during hypoglycemia (Rho <= -0.55). M-value correlated positively with changes of IL-12B and VEGF-A during hyperglycemia (Rho >= 0.51). Results above were significant (p < 0.05).
+
+ CONCLUSION: Overall, hyperinsulinemia, hypo- and hyperglycemia led to suppression of several inflammatory markers and this tended to be more marked in individuals with obesity, insulin resistance and dysglycemia. Thus, acute glycemic or insulinemic variations do not seem to potentiate possible inflammatory pathways in the development of insulin resistance and disturbed glucose metabolism. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Blood Glucose). 0 (Insulin). 0 (Vascular Endothelial Growth Factor A). 0 (Biomarkers). 0 (CDCP1 protein, human). 0 (Antigens, Neoplasm). 0 (Cell Adhesion Molecules).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1007%2fs12020-023-03433-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lundqvist&issn=1355-008X&title=Endocrine&atitle=Glucose-dependent+inflammatory+responses+in+obese+compared+to+lean+individuals.&volume=81&issue=3&spage=464&epage=476&date=2023&doi=10.1007%2Fs12020-023-03433-4&pmid=37400734&sid=OVID:medline
+
+<212>
+Unique Identifier
+ 37391173
+Title
+ Inflammatory Biomarkers in Older Women with Obesity, Sarcopenia, and Sarcopenic Obesity.
+Source
+ Journal of the American Medical Directors Association. 24(10):1562-1564, 2023 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Teixeira LAC; Avelar NCP; Parentoni AN; Santos JM; Leopoldino AAO; Costa SP; Arrieiro AN; Soares LA; Nobre JNP; Brant FP; Figueiredo PHS; Mendonca VA; Lacerda ACR
+Authors Full Name
+ Teixeira, Leonardo A C; Avelar, Nubia C P; Parentoni, Adriana N; Santos, Jousielle M; Leopoldino, Amanda A O; Costa, Sabrina P; Arrieiro, Arthur N; Soares, Luana A; Nobre, Juliana N P; Brant, Franciane P; Figueiredo, Pedro H S; Mendonca, Vanessa A; Lacerda, Ana C R.
+Institution
+ Teixeira, Leonardo A C. Postgraduate Program in Health Sciences (PPGCS) of Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Avelar, Nubia C P. Department of Health Sciences of University of Santa Catarina (UFSC), Ararangua, Santa Catarina, Brazil.
+ Parentoni, Adriana N. Physiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.
+ Santos, Jousielle M. Postgraduate Multicenter Program in Physiological Sciences (PPGCF), Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Leopoldino, Amanda A O. Postgraduate Program in Health Sciences of Faculty of Medical Science of Minas (FCMMG), Belo Horizonte, Minas Gerais, Brazil.
+ Costa, Sabrina P. Program in Rehabilitation and Functional Performance (PPGReab), Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.
+ Arrieiro, Arthur N. Postgraduate Program in Health Sciences (PPGCS) of Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Soares, Luana A. Program in Rehabilitation and Functional Performance (PPGReab), Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.
+ Nobre, Juliana N P. Postgraduate Program in Health Sciences (PPGCS) of Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Brant, Franciane P. Postgraduate Program in Health Sciences (PPGCS) of Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
+ Figueiredo, Pedro H S. Physiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.
+ Mendonca, Vanessa A. Physiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.
+ Lacerda, Ana C R. Postgraduate Program in Health Sciences (PPGCS) of Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil; Postgraduate Multicenter Program in Physiological Sciences (PPGCF), Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil; Program in Rehabilitation and Functional Performance (PPGReab), Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.
+MeSH Subject Headings
+ Humans
+ Female
+ Aged
+ *Sarcopenia
+ Obesity
+ Biomarkers
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Letter. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.jamda.2023.05.022
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Teixeira&issn=1525-8610&title=Journal+of+the+American+Medical+Directors+Association&atitle=Inflammatory+Biomarkers+in+Older+Women+with+Obesity%2C+Sarcopenia%2C+and+Sarcopenic+Obesity.&volume=24&issue=10&spage=1562&epage=1564&date=2023&doi=10.1016%2Fj.jamda.2023.05.022&pmid=37391173&sid=OVID:medline
+
+<213>
+Unique Identifier
+ 37382193
+Title
+ Biomarker guided management of hypertension. [Review]
+Source
+ Current Opinion in Nephrology & Hypertension. 32(5):427-433, 2023 09 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kotta PA; Nambi V
+Authors Full Name
+ Kotta, Prasanti Alekhya; Nambi, Vijay.
+Institution
+ Kotta, Prasanti Alekhya. Department of Internal Medicine, Baylor College of Medicine.
+ Nambi, Vijay. Michael E DeBakey Veterans Affairs Hospital, Department of Cardiovascular Research and Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas, USA.
+MeSH Subject Headings
+ Humans
+ Aged
+ Hypertension/di [Diagnosis]
+ Hypertension/dt [Drug Therapy]
+ Hypertension/ep [Epidemiology]
+ *Hypertension
+ Biomarkers
+ Risk Factors
+ Risk Assessment
+ Obesity
+ Peptide Fragments
+Abstract
+ PURPOSE OF REVIEW: Approximately 1.28 billion people are affected by hypertension globally and the incidence of hypertension is on an upward trajectory with an aging population and increasing burden of risk factors including obesity. Despite low-cost, highly-effectively, easy-to-treat strategies, it is estimated that ~720 million people are not receiving the treatment they need for optimal hypertension management. Several factors contribute to this including an unwillingness to be treated for an asymptomatic condition.
+
+ RECENT FINDINGS: Biomarkers such as troponin, B-type Natriuretic Peptide (BNP), N-terminal-pro hormone BNP (NT-proBNP), uric acid, microalbuminuria have been found to be associated with adverse clinical outcomes among individuals with hypertension. Biomarkers also allow for identification of asymptomatic organ damage.
+
+ SUMMARY: Biomarkers have the ability to identify higher risk individuals in whom risk-benefit for therapies may be most favorable, helping optimize the net benefit of therapy. Whether biomarkers can help guide therapy intensity and choice remains to be tested. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments).
+Publication Type
+ Review. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1097%2fMNH.0000000000000905
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kotta&issn=1062-4821&title=Current+Opinion+in+Nephrology+%26+Hypertension&atitle=Biomarker+guided+management+of+hypertension.&volume=32&issue=5&spage=427&epage=433&date=2023&doi=10.1097%2FMNH.0000000000000905&pmid=37382193&sid=OVID:medline
+
+<214>
+Unique Identifier
+ 37381978
+Title
+ Pre-diagnosis lipid levels and mortality after obesity-related cancer diagnosis in the Women's Health Initiative cardiovascular disease biomarker cohort.
+Source
+ Cancer Medicine. 12(15):16626-16636, 2023 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hovsepyan G; Barac A; Brasky TM; Shadyab AH; Lehman A; McLaughlin EM; Saquib N; Iyengar NM; Wild RA; Caan BJ; Desai P; Beebe Dimmer J; Thomson CA; Simon MS
+Author NameID
+ Brasky, Theodore M; ORCID: https://orcid.org/0000-0001-7781-609X
+ Desai, Pinkal; ORCID: https://orcid.org/0000-0002-9816-7284
+ Beebe Dimmer, Jennifer; ORCID: https://orcid.org/0000-0002-4320-739X
+ Simon, Michael S; ORCID: https://orcid.org/0000-0002-3237-6761
+Authors Full Name
+ Hovsepyan, Gayane; Barac, Ana; Brasky, Theodore M; Shadyab, Aladdin H; Lehman, Amy; McLaughlin, Eric M; Saquib, Nazmus; Iyengar, Neil M; Wild, Robert A; Caan, Bette J; Desai, Pinkal; Beebe Dimmer, Jennifer; Thomson, Cynthia A; Simon, Michael S.
+Institution
+ Hovsepyan, Gayane. Wayne State University School of Medicine, Detroit, Michigan, USA.
+ Hovsepyan, Gayane. Scripps Green Internal Medicine Residency Program, La Jolla, California, USA.
+ Barac, Ana. Georgetown University, Washington, District of Columbia, USA.
+ Barac, Ana. Inova Heart and Vascular Institute, Falls Church, Virginia, USA.
+ Brasky, Theodore M. Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
+ Shadyab, Aladdin H. Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA.
+ Lehman, Amy. Center for Biostatistics, Ohio State University, Columbus, Ohio, USA.
+ McLaughlin, Eric M. Center for Biostatistics, Ohio State University, Columbus, Ohio, USA.
+ Saquib, Nazmus. College of Medicine, Sulaiman AlRajhi University, Al Bukayriyah, Saudi Arabia.
+ Iyengar, Neil M. Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Wild, Robert A. University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
+ Caan, Bette J. Division of Research, Kaiser Permanente Medical Program of Northern California, Oakland, California, USA.
+ Desai, Pinkal. Department of Oncology, Weill Cornell Medical Center, New York, New York, USA.
+ Beebe Dimmer, Jennifer. Wayne State University School of Medicine, Detroit, Michigan, USA.
+ Beebe Dimmer, Jennifer. Department of Oncology, Barbara Ann Karmanos Cancer Institute at Wayne Sate University, Detroit, Michigan, USA.
+ Thomson, Cynthia A. Department of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health and Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
+ Simon, Michael S. Wayne State University School of Medicine, Detroit, Michigan, USA.
+ Simon, Michael S. Department of Oncology, Barbara Ann Karmanos Cancer Institute at Wayne Sate University, Detroit, Michigan, USA.
+MeSH Subject Headings
+ Female
+ Humans
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Risk Factors
+ Women's Health
+ Obesity/co [Complications]
+ Biomarkers
+ Cholesterol
+ Multiple Myeloma/co [Complications]
+ *Multiple Myeloma
+ Cholesterol, HDL
+Keyword Heading
+ lipids
+ obesity related cancer
+ survival
+ women's health initiative
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Published studies have demonstrated inconclusive relationships between serum lipid levels and mortality after cancer.
+
+ METHODS: The primary objective was to evaluate the relationship between fasting lipid levels and mortality after cancer. Data were obtained on baseline lipids and outcomes after cancer from 1263 postmenopausal women diagnosed with 13 obesity-related cancers who were part of the Women's Health Initiative (WHI) lipid biomarkers cohort. Obesity-related cancers included incident invasive cancers of the breast, colorectum, endometrium, esophagus (adenocarcinoma), kidney, liver, gallbladder, pancreas, ovaries, small intestine, thyroid, stomach, as well as multiple myeloma. Baseline lipid measurements included high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and non-HDL-cholesterol. Outcomes were all cause, cancer-specific, and CVD mortality. Multivariable Cox proportional hazards models were used to measure associations between lipid levels and mortality (all cause, cancer, and CVD) after a cancer diagnosis, with lipids analyzed as continuous variables.
+
+ RESULTS: Among women with obesity-related cancer, there were 707 deaths, of which 379 (54%) were due to cancer and 113 (16%) were due to CVD. Mean time from blood draw to cancer diagnosis was 5.1 years (range: 0.05-10 years). LDL-C values above the 95th percentile were associated with higher risk of all-cause mortality (p < 0.001), and cancer-specific mortality (p < 0.001), but not mortality due to CVD. Non-HDL-C values above the 65th percentile were associated with higher risk of all-cause mortality (p = 0.01) and mortality due to CVD (p = 0.003), but not cancer-specific mortality (p = 0.37). HDL-C values above the 95th percentile were associated with lower all-cause mortality (p = 0.002), and above the 65th percentile with lower cancer-specific mortality (p = 0.003), but no significant relationship with mortality due to CVD was observed.
+
+ CONCLUSIONS: The relationship between pre-diagnosis fasting lipid levels and mortality after cancer diagnosis is complex. These results suggest that improved lipid control through lifestyle and anti-lipid medications could have a meaningful impact on outcomes after cancer. Copyright © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 97C5T2UQ7J (Cholesterol). 0 (Cholesterol, HDL).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1002%2fcam4.6266
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hovsepyan&issn=2045-7634&title=Cancer+Medicine&atitle=Pre-diagnosis+lipid+levels+and+mortality+after+obesity-related+cancer+diagnosis+in+the+Women%27s+Health+Initiative+cardiovascular+disease+biomarker+cohort.&volume=12&issue=15&spage=16626&epage=16636&date=2023&doi=10.1002%2Fcam4.6266&pmid=37381978&sid=OVID:medline
+
+<215>
+Unique Identifier
+ 37364142
+Title
+ Dietary inflammatory index and its relation to the pathophysiological aspects of obesity: a narrative review. [Review]
+Source
+ Archives of Endocrinology & Metabolism. 67(6):e000631, 2023 Jun 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Mello RN; de Gois BP; Kravchychyn ACP; Damaso AR; Horst MA; Lima GC; Corgosinho FC
+Authors Full Name
+ de Mello, Roseli Neves; de Gois, Barbara Paixao; Kravchychyn, Ana Claudia Pelissari; Damaso, Ana Raimunda; Horst, Maria Aderuza; Lima, Glaucia Carielo; Corgosinho, Flavia Campos.
+Institution
+ de Mello, Roseli Neves. Universidade Federal de Goias, Faculdade de Nutricao, Programa de Pos-graduacao em Nutricao e Saude, Goiania, GO, Brasil.
+ de Gois, Barbara Paixao. Universidade Federal de Goias, Faculdade de Nutricao, Programa de Pos-graduacao em Nutricao e Saude, Goiania, GO, Brasil.
+ Kravchychyn, Ana Claudia Pelissari. Universidade Federal de Vicosa, Programa de Pos-Graduacao em Ciencia da Nutricao, Vicosa, MG, Brasil.
+ Damaso, Ana Raimunda. Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Programa de Pos-graduacao em Nutricao, Sao Paulo, SP, Brasil.
+ Horst, Maria Aderuza. Universidade Federal de Goias, Faculdade de Nutricao, Programa de Pos-graduacao em Nutricao e Saude, Goiania, GO, Brasil.
+ Lima, Glaucia Carielo. Universidade Federal de Goias, Faculdade de Nutricao, Programa de Pos-graduacao em Nutricao e Saude, Goiania, GO, Brasil.
+ Corgosinho, Flavia Campos. Universidade Federal de Goias, Faculdade de Nutricao, Programa de Pos-graduacao em Nutricao e Saude, Goiania, GO, Brasil.
+ Corgosinho, Flavia Campos. Universidade Federal de Goias, Programa de Pos-graduacao e Ciencias da Saude, Goiania, GO, Brasil, flaviacorgosinho@hotmail.com.
+MeSH Subject Headings
+ Humans
+ Biomarkers
+ *Diet
+ Obesity/co [Complications]
+ *Obesity
+ Inflammation
+ C-Reactive Protein/an [Analysis]
+Keyword Heading
+ Inflammation
+ biomarkers
+ cytokines
+ diet
+ weight gain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity, a complex disease that involves energy imbalance and chronic low-grade inflammation, is implicated in the pathogenesis of several chronic non-communicable diseases. As dietary components modulate the human body's inflammatory status, the Dietary Inflammatory Index (DII R), a literature-derived dietary index, was developed in 2009 to characterize the inflammatory potential of a habitual diet. Abundant research has been conducted to investigate the associations between DII and obesity. In this narrative review, we examined the current state of the science regarding the relationships between DII and the inflammatory pathophysiological aspects related to obesity. DII is associated with inflammation in obesity. The most pro-inflammatory diet was directly related to higher levels of pro-inflammatory markers, which included C-reactive protein (CRP), interleukin-6 (IL-6), IL-1beta, and tumor necrosis factor-alpha (TNF-alpha). Therefore, evidence suggests that the use of the DII may be useful for understanding the relationship between diet and the inflammatory process related to obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.20945%2f2359-3997000000631
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Mello&issn=2359-3997&title=Archives+of+Endocrinology+%26+Metabolism&atitle=Dietary+inflammatory+index+and+its+relation+to+the+pathophysiological+aspects+of+obesity%3A+a+narrative+review.&volume=67&issue=6&spage=e000631&epage=&date=2023&doi=10.20945%2F2359-3997000000631&pmid=37364142&sid=OVID:medline
+
+<216>
+Unique Identifier
+ 37341438
+Title
+ Examining the associations between testosterone and biomarkers as men age.
+Source
+ American Journal of Human Biology. 35(11):e23942, 2023 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Smith SJ; Bekele D; Lopresti AL; Fairchild TJ
+Author NameID
+ Smith, Stephen J; ORCID: https://orcid.org/0000-0002-3875-4815
+Authors Full Name
+ Smith, Stephen J; Bekele, Daniel; Lopresti, Adrian L; Fairchild, Timothy J.
+Institution
+ Smith, Stephen J. Clinical Research Australia, Perth, Western Australia, Australia.
+ Smith, Stephen J. The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia, Australia.
+ Bekele, Daniel. College of Natural and Computational Sciences, Dire Dawa University, Dire Dawa, Ethiopia.
+ Lopresti, Adrian L. Clinical Research Australia, Perth, Western Australia, Australia.
+ Lopresti, Adrian L. The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia, Australia.
+ Fairchild, Timothy J. The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia, Australia.
+MeSH Subject Headings
+ Humans
+ Male
+ Adolescent
+ Adult
+ Testosterone
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Nutrition Surveys
+ *Insulin Resistance
+ Cross-Sectional Studies
+ Insulin
+ Obesity/ep [Epidemiology]
+ Biomarkers
+ Glucose
+Abstract
+ OBJECTIVES: Testosterone concentrations in men decline with advancing age. However, the cause of the decline is yet to be fully elucidated. Therefore, the aims of this study were to examine the associations between chronic diseases such as obesity and type 2 diabetes mellitus (T2DM) with total testosterone (TT) and sex hormone-binding globulin (SHBG), using a large nationally-representative data set (National Health and Nutrition Examination Survey; NHANES).
+
+ METHODS: NHANES is a cross-sectional survey, physical examination, and laboratory evaluation of a nationally-representative sample of a non-institutionalized United States population. Male participants aged >=18 years during the NHANES 2013-2014 and NHANES 2015-2016 survey periods were selected for this analysis. The analysis included the following data: body mass index (BMI), oral glucose tolerance test (OGTT), homeostatic model assessment of insulin resistance (HOMA-IR), insulin, glucose, and age.
+
+ RESULTS: An overweight or obese condition was significantly inversely associated with TT and SHBG, even after adjusting for other variables. Several variables associated with T2DM (OGTT, HOMA-IR, insulin, and glucose) were also inversely associated with TT; however, only the associations between OGTT and insulin with TT remained significant after adjusting for the other variables. Insulin and HOMA-IR levels were significantly inversely associated with SHBG; however, only the association between SHBG and pre-diabetic HOMA-IR levels remained significant after adjusting for the other variables. OGTT became significantly associated with SHBG after adjusting for the other variables. Age was significantly inversely associated with TT, but positively associated with SHBG, even after adjusting for other variables.
+
+ CONCLUSION: The results of the present study, which is the largest to date, indicate that a marker of obesity, BMI, and some markers of T2DM are both independently and significantly inversely associated with TT and SHBG. Copyright © 2023 The Authors. American Journal of Human Biology published by Wiley Periodicals LLC.
+Registry Number/Name of Substance
+ 3XMK78S47O (Testosterone). 0 (Insulin). 0 (Biomarkers). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1002%2fajhb.23942
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Smith&issn=1042-0533&title=American+Journal+of+Human+Biology&atitle=Examining+the+associations+between+testosterone+and+biomarkers+as+men+age.&volume=35&issue=11&spage=e23942&epage=&date=2023&doi=10.1002%2Fajhb.23942&pmid=37341438&sid=OVID:medline
+
+<217>
+Unique Identifier
+ 37295784
+Title
+ Association Between Sleep Time and Pro- and Anti-Inflammatory Biomarkers Is Mediated by Abdominal Obesity Among Adolescents.
+Source
+ Journal of Physical Activity & Health. 20(10):926-933, 2023 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ De Moraes ACF; Medeiros-Oliveira VC; Burford K; Schaan BD; Bloch K; de Carvalho KMB; Cureau FV; Nascimento-Ferreira MV
+Author NameID
+ De Moraes, Augusto Cesar Ferreira; ORCID: https://orcid.org/0000-0002-5763-435X
+ Medeiros-Oliveira, Vanessa Cassia; ORCID: https://orcid.org/0000-0001-6032-6748
+ Burford, Katie; ORCID: https://orcid.org/0000-0001-5500-9609
+ Schaan, Beatriz D; ORCID: https://orcid.org/0000-0002-2128-8387
+ Bloch, Katia; ORCID: https://orcid.org/0000-0002-6992-3159
+ de Carvalho, Kenia Mara Baiocchi; ORCID: https://orcid.org/0000-0003-2799-1038
+ Cureau, Felipe Vogt; ORCID: https://orcid.org/0000-0001-7255-9717
+ Nascimento-Ferreira, Marcus Vinicius; ORCID: https://orcid.org/0000-0002-6344-1044
+Authors Full Name
+ De Moraes, Augusto Cesar Ferreira; Medeiros-Oliveira, Vanessa Cassia; Burford, Katie; Schaan, Beatriz D; Bloch, Katia; de Carvalho, Kenia Mara Baiocchi; Cureau, Felipe Vogt; Nascimento-Ferreira, Marcus Vinicius.
+Institution
+ De Moraes, Augusto Cesar Ferreira. The University of Texas Health Science Center at Houston School of Public Health Austin Campus, Department of Epidemiology, Human Genetics, and Environmental Science, Michael & Susan Dell Center for Healthy Living, Austin, TX,USA.
+ De Moraes, Augusto Cesar Ferreira. Department of Epidemiology, Graduate Program in Public Health and Graduate Program in Epidemiology, School of Public Health, University of Sao Paulo, Sao Paulo, SP,Brazil.
+ De Moraes, Augusto Cesar Ferreira. YCARE (Youth/Child and cArdiovascular Risk and Environmental) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP,Brazil.
+ Medeiros-Oliveira, Vanessa Cassia. Department of Epidemiology, Graduate Program in Public Health and Graduate Program in Epidemiology, School of Public Health, University of Sao Paulo, Sao Paulo, SP,Brazil.
+ Medeiros-Oliveira, Vanessa Cassia. YCARE (Youth/Child and cArdiovascular Risk and Environmental) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP,Brazil.
+ Burford, Katie. The University of Texas Health Science Center at Houston School of Public Health Austin Campus, Department of Epidemiology, Human Genetics, and Environmental Science, Michael & Susan Dell Center for Healthy Living, Austin, TX,USA.
+ Schaan, Beatriz D. Faculty of Medicine, Graduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS,Brazil.
+ Schaan, Beatriz D. Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS,Brazil.
+ Schaan, Beatriz D. Faculty of Medicine, Graduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS,Brazil.
+ Bloch, Katia. Instituto de Estudos em Saude Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ,Brazil.
+ de Carvalho, Kenia Mara Baiocchi. Graduate Program in Human Nutrition, Universidade de Brasilia, Brazil.
+ Cureau, Felipe Vogt. Graduate Program in Cardiology and Cardiovascular Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS,Brazil.
+ Nascimento-Ferreira, Marcus Vinicius. YCARE (Youth/Child and cArdiovascular Risk and Environmental) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP,Brazil.
+ Nascimento-Ferreira, Marcus Vinicius. HEALth, pHYsical activity and Behavior ReseArch (HEALTHY-BRA) group, Federal University of Tocantins, Campus Miracema, Miracema, TO,Brazil.
+MeSH Subject Headings
+ Humans
+ Adolescent
+ *Obesity, Abdominal
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Cross-Sectional Studies
+ Adiponectin
+ Exercise
+ Obesity
+ Biomarkers
+ Sleep
+ Waist Circumference
+ Body Mass Index
+Keyword Heading
+ inflammatory
+ life styles
+ waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Movement behaviors and abdominal obesity are associated with higher inflammatory biomarkers. However, the role of waist circumference as a mediating factor is still unknown. Thus, our aims were to (1) test the associations between 24-hour movement behavior variables (physical activity, sedentary behavior, and sleep), abdominal obesity, and pro- and anti-inflammatory biomarkers; and (2) investigate whether abdominal obesity had a mediating effect between the investigated associations.
+
+ METHODS: This multicenter cross-sectional study included 3591 adolescents (aged 12-17 y) from 4 Brazilian cities. Waist circumference (in centimeters; at half the distance between the iliac crest and at the lower costal margin), 24-hour movement behaviors (validated questionnaire), high-sensitive C-reactive protein, and adiponectin (serum plasma) were evaluated. We used multiple mediation regression models (95% confidence interval) to determine if waist circumference mediated the association between 24-hour movement behaviors and pro- and anti-inflammatory biomarkers.
+
+ RESULTS: The results revealed that screen time and moderate to vigorous physical activity were not associated with pro- or anti-inflammatory biomarkers. However, sleep duration (in hours per day) was negatively associated with pro- (C-reactive protein, beta = -0.08; 95% confidence interval, -0.38 to -0.02) and anti- (adiponectin, beta = -0.31; 95% confidence interval, -2.13 to -0.12) inflammatory biomarkers. Our results also showed that waist circumference mediated the association between sleep duration and high-sensitive C-reactive protein (2.7%), and adiponectin (2.8%).
+
+ CONCLUSION: Sleep duration was inversely associated with pro- and anti-inflammatory biomarkers, and these relations were mediated by abdominal obesity. Therefore, adolescents having healthy sleep can have implications for reducing waist circumference and inflammatory indicators.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Multicenter Study. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1123%2fjpah.2022-0468
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=De+Moraes&issn=1543-3080&title=Journal+of+Physical+Activity+%26+Health&atitle=Association+Between+Sleep+Time+and+Pro-+and+Anti-Inflammatory+Biomarkers+Is+Mediated+by+Abdominal+Obesity+Among+Adolescents.&volume=20&issue=10&spage=926&epage=933&date=2023&doi=10.1123%2Fjpah.2022-0468&pmid=37295784&sid=OVID:medline
+
+<218>
+Unique Identifier
+ 37295218
+Title
+ Body mass index, systemic inflammation and cognitive performance in adolescents: A cross-sectional study.
+Source
+ Psychoneuroendocrinology. 156:106298, 2023 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Caldu X; Prats-Soteras X; Garcia-Garcia I; Prunell-Castane A; Sanchez-Garre C; Cano N; Tor E; Sender-Palacios MJ; Ottino-Gonzalez J; Garolera M; Jurado MA
+Authors Full Name
+ Caldu, Xavier; Prats-Soteras, Xavier; Garcia-Garcia, Isabel; Prunell-Castane, Anna; Sanchez-Garre, Consuelo; Cano, Neus; Tor, Encarnacio; Sender-Palacios, Maria-Jose; Ottino-Gonzalez, Jonatan; Garolera, Maite; Jurado, Maria Angeles.
+Institution
+ Caldu, Xavier. Departament de Psicologia Clinica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociencies, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Recerca Sant Joan de Deu, C/ Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain.
+ Prats-Soteras, Xavier. Departament de Psicologia Clinica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociencies, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Recerca Sant Joan de Deu, C/ Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain.
+ Garcia-Garcia, Isabel. Departament de Psicologia Clinica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociencies, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Clinique la Prairie, Montreux, Rue du Lac 142, 1815 Clarens, Switzerland.
+ Prunell-Castane, Anna. Departament de Psicologia Clinica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociencies, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Recerca Sant Joan de Deu, C/ Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain.
+ Sanchez-Garre, Consuelo. Unitat d'Endocrinologia Pediatrica, Departament de Pediatria, Hospital de Terrassa, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain.
+ Cano, Neus. Unitat de Neuropsicologia, Hospital de Terrassa, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain; Brain, Cognition and Behavior Clinical Research Group, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain.
+ Tor, Encarnacio. Centre d'Atencio Primaria Terrassa Nord, Consorci Sanitari de Terrassa, Av del Valles 451, 08226 Terrassa, Spain.
+ Sender-Palacios, Maria-Jose. Centre d'Atencio Primaria Terrassa Nord, Consorci Sanitari de Terrassa, Av del Valles 451, 08226 Terrassa, Spain.
+ Ottino-Gonzalez, Jonatan. Division of Endocrinology, The Saban Research Institute, Children's Hospital Los Angeles, United States.
+ Garolera, Maite. Unitat de Neuropsicologia, Hospital de Terrassa, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain; Brain, Cognition and Behavior Clinical Research Group, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain. Electronic address: mgarolera@cst.cat.
+ Jurado, Maria Angeles. Departament de Psicologia Clinica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociencies, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Recerca Sant Joan de Deu, C/ Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain.
+MeSH Subject Headings
+ Humans
+ Adolescent
+ Body Mass Index
+ Cross-Sectional Studies
+ *Tumor Necrosis Factor-alpha
+ Obesity/px [Psychology]
+ *Obesity
+ Cognition
+ Inflammation
+ Memory, Short-Term
+ Biomarkers
+ Body Weight
+Keyword Heading
+ Cognition
+ Executive functions
+ Inflammation
+ Memory
+ Obesity
+ Overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Excessive body weight has been related to lower cognitive performance. One of the mechanisms through which excess body weight may affect cognition is inflammation.
+
+ HYPOTHESIS: Our hypothesis is that both body mass index (BMI) and circulating levels of inflammatory biomarkers will be negatively related to cognitive performance.
+
+ DESIGN: Cross-sectional study.
+
+ SETTING: Users of the public health centres of the Consorci Sanitari de Terrassa (Terrassa, Spain) between 2010 and 2017 aged 12-21 years.
+
+ PARTICIPANTS: One hundred and five adolescents (46 normoweight, 18 overweight, 41 obese).
+
+ MEASUREMENTS: Levels of high sensitivity C-reactive protein, interleukin 6, tumour necrosis factor alpha (TNFalpha) and fibrinogen were determined from blood samples. Cognitive performance was evaluated and six cognitive composites were obtained: working memory, cognitive flexibility, inhibitory control, decision-making, verbal memory, and fine motor speed. A single multivariate general lineal model was used to assess the influence of the four inflammatory biomarkers, as well as participants' BMI, sex, and age on the 6 cognitive indexes.
+
+ RESULTS: An inverse relationship between BMI and inhibitory control (F = 5.688, p = .019; beta = -0.212, p = .031), verbal memory (F = 5.404, p = .022; beta = -0.255, p = .009) and fine motor speed (F = 9.038, p = .003; beta = -0.319, p = .001) was observed. Levels of TNFalpha and fibrinogen were inversely related to inhibitory control (F = 5.055, p = .027; beta = -0.226, p = .021) and verbal memory (F = 4.732, p = .032; beta = -0.274, p = .005), respectively.
+
+ LIMITATIONS: The cross-sectional nature of the study, the use of cognitive tests designed for clinical purposes, and the use of BMI as a proxy for adiposity are limitations of our study that must be taken into account when interpreting results.
+
+ CONCLUSIONS: Our data indicate that some components of executive functions, together with verbal memory, are sensitive to specific obesity-related inflammatory agents at early ages. Copyright © 2023 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Tumor Necrosis Factor-alpha). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1016%2fj.psyneuen.2023.106298
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Caldu&issn=0306-4530&title=Psychoneuroendocrinology&atitle=Body+mass+index%2C+systemic+inflammation+and+cognitive+performance+in+adolescents%3A+A+cross-sectional+study.&volume=156&issue=&spage=106298&epage=&date=2023&doi=10.1016%2Fj.psyneuen.2023.106298&pmid=37295218&sid=OVID:medline
+
+<219>
+Unique Identifier
+ 37278618
+Title
+ Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort.
+Source
+ eLife. 12, 2023 06 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Robinson O; Lau CE; Joo S; Andrusaityte S; Borras E; de Prado-Bert P; Chatzi L; Keun HC; Grazuleviciene R; Gutzkow KB; Maitre L; Martens DS; Sabido E; Siroux V; Urquiza J; Vafeiadi M; Wright J; Nawrot TS; Bustamante M; Vrijheid M
+Author NameID
+ Robinson, Oliver; ORCID: https://orcid.org/0000-0002-4735-0468
+ Gutzkow, Kristine B; ORCID: https://orcid.org/0000-0002-6716-5921
+ Sabido, Eduard; ORCID: https://orcid.org/0000-0001-6506-7714
+Authors Full Name
+ Robinson, Oliver; Lau, ChungHo E; Joo, Sungyeon; Andrusaityte, Sandra; Borras, Eva; de Prado-Bert, Paula; Chatzi, Lida; Keun, Hector C; Grazuleviciene, Regina; Gutzkow, Kristine B; Maitre, Lea; Martens, Dries S; Sabido, Eduard; Siroux, Valerie; Urquiza, Jose; Vafeiadi, Marina; Wright, John; Nawrot, Tim S; Bustamante, Mariona; Vrijheid, Martine.
+Institution
+ Robinson, Oliver. Muedical Research Council Centre for Environment and Health, Imperial College London, London, United Kingdom.
+ Robinson, Oliver. Mohn Centre for Children's Health and Well-being, School of Public Health, Imperial College London, London, United Kingdom.
+ Lau, ChungHo E. Muedical Research Council Centre for Environment and Health, Imperial College London, London, United Kingdom.
+ Joo, Sungyeon. Muedical Research Council Centre for Environment and Health, Imperial College London, London, United Kingdom.
+ Andrusaityte, Sandra. Department of Environmental Science, Vytautas Magnus University, Kaunas, Lithuania.
+ Borras, Eva. Center for Genomics Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
+ Borras, Eva. Universitat Pompeu Fabra (UPF), Barcelona, Spain.
+ de Prado-Bert, Paula. Universitat Pompeu Fabra (UPF), Barcelona, Spain.
+ de Prado-Bert, Paula. Institute for Global Health (ISGlobal), Barcelona, Spain.
+ de Prado-Bert, Paula. CIBER Epidemiologa y Salud Publica (CIBERESP), Madrid, Spain.
+ Chatzi, Lida. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, United States.
+ Keun, Hector C. Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
+ Keun, Hector C. Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer; Imperial College London, London, United Kingdom.
+ Grazuleviciene, Regina. Department of Environmental Science, Vytautas Magnus University, Kaunas, Lithuania.
+ Gutzkow, Kristine B. Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
+ Maitre, Lea. Universitat Pompeu Fabra (UPF), Barcelona, Spain.
+ Maitre, Lea. Institute for Global Health (ISGlobal), Barcelona, Spain.
+ Maitre, Lea. CIBER Epidemiologa y Salud Publica (CIBERESP), Madrid, Spain.
+ Martens, Dries S. Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
+ Sabido, Eduard. Center for Genomics Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
+ Sabido, Eduard. Universitat Pompeu Fabra (UPF), Barcelona, Spain.
+ Siroux, Valerie. University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of environmental epidemiology applied to the development and respiratory health, Institute for Advanced Biosciences, 38000 Grenoble, France.
+ Urquiza, Jose. Universitat Pompeu Fabra (UPF), Barcelona, Spain.
+ Urquiza, Jose. Institute for Global Health (ISGlobal), Barcelona, Spain.
+ Urquiza, Jose. CIBER Epidemiologa y Salud Publica (CIBERESP), Madrid, Spain.
+ Vafeiadi, Marina. Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece.
+ Wright, John. Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, United Kingdom.
+ Nawrot, Tim S. Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
+ Bustamante, Mariona. Universitat Pompeu Fabra (UPF), Barcelona, Spain.
+ Bustamante, Mariona. Institute for Global Health (ISGlobal), Barcelona, Spain.
+ Bustamante, Mariona. CIBER Epidemiologa y Salud Publica (CIBERESP), Madrid, Spain.
+ Vrijheid, Martine. Universitat Pompeu Fabra (UPF), Barcelona, Spain.
+ Vrijheid, Martine. Institute for Global Health (ISGlobal), Barcelona, Spain.
+ Vrijheid, Martine. CIBER Epidemiologa y Salud Publica (CIBERESP), Madrid, Spain.
+MeSH Subject Headings
+ Adult
+ Humans
+ Child
+ Child, Preschool
+ Infant
+ *Multiomics
+ Aging/ge [Genetics]
+ *Aging
+ DNA Methylation
+ Risk Factors
+ Obesity/ge [Genetics]
+ Biomarkers
+ Epigenesis, Genetic
+Keyword Heading
+ biological age
+ child development
+ computational biology
+ epidemiology
+ global health
+ human
+ omics
+ systems biology
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation of accelerated biological age in children and its relationship to development remains unclear. We aimed to clarify the relationship of accelerated biological age, assessed through two established biological age indicators, telomere length and DNA methylation age, and two novel candidate biological age indicators, to child developmental outcomes, including growth and adiposity, cognition, behavior, lung function and the onset of puberty, among European school-age children participating in the HELIX exposome cohort.
+
+ Methods: The study population included up to 1173 children, aged between 5 and 12 years, from study centres in the UK, France, Spain, Norway, Lithuania, and Greece. Telomere length was measured through qPCR, blood DNA methylation, and gene expression was measured using microarray, and proteins and metabolites were measured by a range of targeted assays. DNA methylation age was assessed using Horvath's skin and blood clock, while novel blood transcriptome and 'immunometabolic' (based on plasma proteins and urinary and serum metabolites) clocks were derived and tested in a subset of children assessed six months after the main follow-up visit. Associations between biological age indicators with child developmental measures as well as health risk factors were estimated using linear regression, adjusted for chronological age, sex, ethnicity, and study centre. The clock derived markers were expressed as DELTA age (i.e. predicted minus chronological age).
+
+ Results: Transcriptome and immunometabolic clocks predicted chronological age well in the test set (r=0.93 and r=0.84 respectively). Generally, weak correlations were observed, after adjustment for chronological age, between the biological age indicators.Among associations with health risk factors, higher birthweight was associated with greater immunometabolic DELTA age, smoke exposure with greater DNA methylation DELTA age, and high family affluence with longer telomere length.Among associations with child developmental measures, all biological age markers were associated with greater BMI and fat mass, and all markers except telomere length were associated with greater height, at least at nominal significance (p<0.05). Immunometabolic DELTA age was associated with better working memory (p=4 e-3) and reduced inattentiveness (p=4 e-4), while DNA methylation DELTA age was associated with greater inattentiveness (p=0.03) and poorer externalizing behaviors (p=0.01). Shorter telomere length was also associated with poorer externalizing behaviors (p=0.03).
+
+ Conclusions: In children, as in adults, biological aging appears to be a multi-faceted process and adiposity is an important correlate of accelerated biological aging. Patterns of associations suggested that accelerated immunometabolic age may be beneficial for some aspects of child development while accelerated DNA methylation age and telomere attrition may reflect early detrimental aspects of biological aging, apparent even in children.
+
+ Funding: UK Research and Innovation (MR/S03532X/1); European Commission (grant agreement numbers: 308333; 874583). Copyright © 2023, Robinson et al.
+Other Abstract
+ plain-language-summary
+ Although age is generally measured by the number of years since birth, many factors contribute to the rate at which a person physically ages. In adults, linking these measurements to age gives a measure of overall health and resilience. This 'biological age' offers a better prediction of remaining life and disease risk than the number of years lived. Multiple factors can be used to calculate biological age, such as measuring the length of telomeres - protective caps on the end of chromosomes - which shorten as people age. The rate at which they shorten can give an indication of how quickly someone is ageing. Researchers can also study epigenetic factors: these mechanisms lead to certain genes being switched on or off, and they can be combined into a 'epigenetic clock' to assess biological age. However, compared with adults, the relationship between biological age and child health and developmental maturity is less well understood. Robinson et al. studied 1,173 school-aged children from six European countries, measuring telomere length, epigenetic factors and other biological indicators related to metabolism and the immune system. The relationships between these factors and an array of child developmental measures such as height, weight, behaviour and the age of onset of puberty were established. The findings showed that biological age indicators are only weakly linked to each other in children. Despite this, biological age was related to greater amount of body fat across all tested indicators - which is also associated with biological age in adults and is an important determinant of lifespan. Among several observed effects on development, analysis found that shorter telomere length and older epigenetic age were associated with greater behavioural problems, suggesting they may be detrimental to child development. On the other hand, a greater age due to metabolic and immune related changes was associated with greater cognitive and behavioural maturity. Environmental factors were also linked to biological ageing, with children exposed to smoking in their homes or while their mother was pregnant displaying an older epigenetic age. Robinson et al. showed that biological ageing in children is multifaceted and can have both beneficial and harmful impacts on development. This knowledge is important for identifying early life risk factors that might influence healthy ageing in later life. Future work will help researchers to understand these complex interactions and the long-term consequences for health and well-being.
+ Language: English
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.7554%2feLife.85104
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Robinson&issn=2050-084X&title=eLife&atitle=Associations+of+four+biological+age+markers+with+child+development%3A+A+multi-omic+analysis+in+the+European+HELIX+cohort.&volume=12&issue=&spage=&epage=&date=2023&doi=10.7554%2FeLife.85104&pmid=37278618&sid=OVID:medline
+
+<220>
+Unique Identifier
+ 37252704
+Title
+ Evaluation of subclinical atherosclerosis in obese patients with three noninvasive methods: Arterial stiffness, carotid intima-media thickness, and biomarkers of endothelial dysfunction.
+Source
+ Archives of Endocrinology & Metabolism. 67(4):e000622, 2023 May 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Can M; Kocabas M; Yarar Z; Burgucu HC; Karakose M; Yerlikaya FH; Turkmen K; Kulaksizoglu M; Karakurt F
+Authors Full Name
+ Can, Mustafa; Kocabas, Muhammet; Yarar, Zeliha; Burgucu, Hatice Caliskan; Karakose, Melia; Yerlikaya, Fatma Humeyra; Turkmen, Kultigin; Kulaksizoglu, Mustafa; Karakurt, Feridun.
+Institution
+ Can, Mustafa. Department of Endocrinology and Metabolism, Mus State Hospital, Mus, Turkey, can1120can@gmail.com.
+ Kocabas, Muhammet. Department of Endocrinology and Metabolism, Tokat State Hospital, Tokat, Turkey.
+ Yarar, Zeliha. Department of Endocrinology and Metabolism, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
+ Burgucu, Hatice Caliskan. Department of Endocrinology and Metabolism, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
+ Karakose, Melia. Department of Endocrinology and Metabolism, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
+ Yerlikaya, Fatma Humeyra. Department of Biochemistry, Faculty of Medicine, Selcuk University, Konya, Turkey.
+ Turkmen, Kultigin. Department of Nephrology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
+ Kulaksizoglu, Mustafa. Department of Endocrinology and Metabolism, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
+ Karakurt, Feridun. Department of Endocrinology and Metabolism, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
+MeSH Subject Headings
+ Humans
+ Carotid Intima-Media Thickness
+ *Vascular Stiffness
+ Pulse Wave Analysis
+ Atherosclerosis/et [Etiology]
+ *Atherosclerosis
+ Obesity/co [Complications]
+ Biomarkers
+ Risk Factors
+Keyword Heading
+ ADAMTS7
+ ADAMTS9
+ Obesity
+ arterial stiffness
+ carotid intima-media thickness
+ endocan
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: In this study, we aimed to evaluate subclinical atherosclerosis in patients with obesity who had cardiovascular disease risk indicators such as arterial stiffness, which is evaluated using pulse wave velocity (PWV), carotid intima-media thickness (CIMT), and biomarkers of endothelial dysfunction such as endocan, ADAMTS97, and ADAMTS9.
+
+ Subjects and methods: Sixty obese subjects, including 23 subjects with body mass index (BMI) >= 40, 37 subjects with BMI >= 30 but < 40, and 60 age-and sex-matched control subjects, were included in our study. Serum endocan, ADAMTS97, and ADAMTS9 levels as well as PWV and CIMT measurements of the subjects in the obese and control groups were performed.
+
+ Results: In the obesity group, PWV levels were significantly higher than they were in the control group and endocan levels were significantly lower than they were in the control group. When we compared the obese group with BMI >= 40 and the control group, the BMI >= 40 group had significantly higher PWV and CIMT levels than the control group had, whereas endocan, ADAMTS7, and ADAMTS9 levels were similar to those of the control group. When we compared the obese group with BMI >= 30 < 40 to the control group, endocan levels were lower in the group with BMI >=30 < 40, and PWV and CIMT levels were similar to the control group.
+
+ Conclusion: We found that arterial stiffness and CIMT increased in obese patients with BMI >= 40 and that increased arterial stiffness was associated with age, systolic blood pressure, and HBA1C. In addition, we found that the endocan levels were lower in obese patients than they were in nonobese control individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.20945%2f2359-3997000000622
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Can&issn=2359-3997&title=Archives+of+Endocrinology+%26+Metabolism&atitle=Evaluation+of+subclinical+atherosclerosis+in+obese+patients+with+three+noninvasive+methods%3A+Arterial+stiffness%2C+carotid+intima-media+thickness%2C+and+biomarkers+of+endothelial+dysfunction.&volume=67&issue=4&spage=e000622&epage=&date=2023&doi=10.20945%2F2359-3997000000622&pmid=37252704&sid=OVID:medline
+
+<221>
+Unique Identifier
+ 37252420
+Title
+ The Potential Relationship Between Serum Irisin Concentration With Inflammatory Cytokines, Oxidative Stress Biomarkers, Glycemic Indices and Lipid Profiles in Obese Patients With Type 2 Diabetes Mellitus: A Pilot Study.
+Source
+ Journal of the Asean Federation of Endocrine Societies. 38(1):45-51, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khajebishak Y; Faghfouri AH; Soleimani A; Ilaei S; Peyrovi S; Madani S; Payahoo L
+Authors Full Name
+ Khajebishak, Yaser; Faghfouri, Amir Hossein; Soleimani, Ali; Ilaei, Sara; Peyrovi, Said; Madani, Sadra; Payahoo, Laleh.
+Institution
+ Khajebishak, Yaser. Department of Nutrition and Food Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.
+ Faghfouri, Amir Hossein. Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
+ Faghfouri, Amir Hossein. Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Soleimani, Ali. Department of Public Health, Maragheh University of Medical Sciences, Maragheh, Iran.
+ Ilaei, Sara. Department of Medicine, Maragheh University of Medical Sciences, Maragheh, Iran.
+ Peyrovi, Said. Department of Medicine, School of Nursing and Allied Medical Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.
+ Madani, Sadra. Department of Nutrition and Food Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.
+ Payahoo, Laleh. Department of Nutrition and Food Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.
+MeSH Subject Headings
+ Female
+ Humans
+ Middle Aged
+ Male
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Cytokines
+ Fibronectins
+ Pilot Projects
+ Glycemic Index
+ Cross-Sectional Studies
+ Interleukin-6
+ Obesity/co [Complications]
+ Biomarkers
+ Oxidative Stress
+ Lipids
+Keyword Heading
+ Irisin
+ glycemic indices
+ inflammation
+ lipid profile
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objectives: Diabetes mellitus is a serious health-treated problem identified by disorders such as insulin resistance, dyslipidemia, and inflammation. Irisin, a newly discovered myokine/adipokine, is involved in metabolic homeostasis. The present study was carried out to investigate the potential relationship between serum irisin with inflammatory cytokines, oxidative stress biomarkers, glycemic indices, and lipid profiles in obese patients with type 2 diabetes mellitus.
+
+ Methodology: This analytical cross-sectional study was conducted on 62 participants (n=32 obese participants with diabetes, n=30 participants with normal weight). The participants answered a demographic questionnaire. Serum irisin, glycemic indices, lipid profiles, inflammatory cytokines and oxidative stress biomarkers were measured using standard methods. The difference between groups was assessed by independent-sample t-test or by a non-parametric equivalent. For qualitative variables, the Chi-Square test was used. Pearson rho coefficient was used to determine the potential relationship between irisin and inflammatory cytokines, oxidative stress biomarkers, glycemic indices, and lipid profiles. A p<0.05 was defined as significant.
+
+ Results: The median (IQR) age of the obese participants with diabetes was 54.0 years (52.2-60.7) and in the normal weight group was 38.0 years (30.0-47.2) (p<0.001). About 78% and 60% of participants in the obese with diabetes and the normal weight groups were females (p>0.05), respectively. Significant differences were observed in serum irisin levels between the two groups, with lower levels (218.74 ng/mL, [144.98-269.26]) noted in the obese with diabetes group compared to the normal weight group (266.68 ng/mL, [200.64-336.57]) with a p=0.024. There was a substantial difference between the two groups regarding IL-6, TNF-alpha, and hs-CRP (p<0.05). IL-6 had a moderate negative correlation with irisin in obese patients with T2DM (r=-0.478, p=0.006).
+
+ Conclusion: Irisin concentration was detected to be lower in obese people with diabetes. A negative relationship was detected between irisin and IL-6. Considering emerging evidence about the beneficial functions of irisin in improving metabolic abnormalities, designing future studies with greater sample sizes that will validate these results is needed. Copyright © 2023 Journal of the ASEAN Federation of Endocrine Societies.
+Registry Number/Name of Substance
+ 0 (Cytokines). 0 (Fibronectins). 0 (Interleukin-6). 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.15605%2fjafes.038.01.13
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khajebishak&issn=0857-1074&title=Journal+of+the+Asean+Federation+of+Endocrine+Societies&atitle=The+Potential+Relationship+Between+Serum+Irisin+Concentration+With+Inflammatory+Cytokines%2C+Oxidative+Stress+Biomarkers%2C+Glycemic+Indices+and+Lipid+Profiles+in+Obese+Patients+With+Type+2+Diabetes+Mellitus%3A+A+Pilot+Study.&volume=38&issue=1&spage=45&epage=51&date=2023&doi=10.15605%2Fjafes.038.01.13&pmid=37252420&sid=OVID:medline
+
+<222>
+Unique Identifier
+ 37245229
+Title
+ Adropin as a potential protective factor of metabolic complications in obese pregnant women with hyperglycaemia diagnosed in early pregnancy.
+Source
+ Journal of Physiology & Pharmacology. 74(1), 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adamczak L; Mantaj U; Gutaj P; Skrypnik D; Ozegowski S; Bogdanski P; Wender-Ozegowska E
+Authors Full Name
+ Adamczak, L; Mantaj, U; Gutaj, P; Skrypnik, D; Ozegowski, S; Bogdanski, P; Wender-Ozegowska, E.
+Institution
+ Adamczak, L. Department of Reproduction, Poznan University of Medical Sciences, Poland. lukaszadamczak91@gmail.com.
+ Adamczak, L. Doctoral School, Poznan University of Medical Sciences, Poznan, Poland.
+ Mantaj, U. Department of Reproduction, Poznan University of Medical Sciences, Poland.
+ Mantaj, U. University Hospital of Obstetrics and Gynaecology, Poznan, Poland.
+ Gutaj, P. Department of Reproduction, Poznan University of Medical Sciences, Poland.
+ Skrypnik, D. Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics; Poznan University of Medical Sciences, Poznan, Poland.
+ Ozegowski, S. II Department of Cardiology, Poznan University of Medical Sciences, Poland.
+ Bogdanski, P. Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics; Poznan University of Medical Sciences, Poznan, Poland.
+ Wender-Ozegowska, E. Department of Reproduction, Poznan University of Medical Sciences, Poland. ewozegow@ump.edu.pl.
+MeSH Subject Headings
+ Humans
+ Female
+ Pregnancy
+ Adult
+ Hyperglycemia/bl [Blood]
+ Diabetes, Gestational/bl [Blood]
+ Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/pa [Pathology]
+ *Diabetes, Gestational
+ Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ *Obesity
+ Intercellular Signaling Peptides and Proteins/bl [Blood]
+ *Intercellular Signaling Peptides and Proteins
+ Biomarkers/bl [Blood]
+Abstract
+ Adropin is a hormone which increases insulin sensitivity. It enhances the oxygenation of glucose in the muscles. The 91 obese pregnant women (BMI >30 kg/m2) with gestational diabetes mellitus (GDM) diagnosed in the first half of pregnancy has been recruited to the study group. The control group consisted of 10 age matched and homogeneous pregnant women with BMI <25 kg/m2. Blood samples were collected on visit V1 - between the 28th and 32nd week and on visit V2 - between the 37th and 39th week of gestation. The ELISA test was used to measure the adropin level. The results in the study group and the control group were compared. Blood samples were collected at the same visits. The median concentration of adropin was 442.2 pg/ml on V1 and 453.1 pg/ml on V2. The increase was significant (p<0.05). Results were significantly lower in the control group's patients, i.e. 57.0 pg/ml (p<0.001) on V1 and 107.9 pg/ml on V2 (p<0.001). The higher adropin level on the V1 and V2 visits were related to patients' lower BMI and better metabolic control. The increase in the adropin level in the third trimester may have been involved in the weight gain reduction, whereas better dietary adherence might have had a compensatory effect on increasing insulin resistance. However, the small control group is a limitation of this study.
+Registry Number/Name of Substance
+ 0 (Enho protein, human). 0 (Intercellular Signaling Peptides and Proteins). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.26402%2fjpp.2023.1.02
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adamczak&issn=0867-5910&title=Journal+of+Physiology+%26+Pharmacology&atitle=Adropin+as+a+potential+protective+factor+of+metabolic+complications+in+obese+pregnant+women+with+hyperglycaemia+diagnosed+in+early+pregnancy.&volume=74&issue=1&spage=&epage=&date=2023&doi=10.26402%2Fjpp.2023.1.02&pmid=37245229&sid=OVID:medline
+
+<223>
+Unique Identifier
+ 37237272
+Title
+ Association of a high-fat diet with I-FABP as a biomarker of intestinal barrier dysfunction driven by metabolic changes in Wistar rats.
+Source
+ Lipids in Health & Disease. 22(1):68, 2023 May 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mahmood A; Faisal MN; Khan JA; Muzaffar H; Muhammad F; Hussain J; Aslam J; Anwar H
+Authors Full Name
+ Mahmood, Aisha; Faisal, Muhammad Naeem; Khan, Junaid Ali; Muzaffar, Humaira; Muhammad, Faqir; Hussain, Jazib; Aslam, Jawad; Anwar, Haseeb.
+Institution
+ Mahmood, Aisha. Department of Physiology, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
+ Faisal, Muhammad Naeem. Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, 38040, Pakistan.
+ Khan, Junaid Ali. Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan.
+ Muzaffar, Humaira. Department of Physiology, Government College University, Faisalabad, 38040, Pakistan.
+ Muhammad, Faqir. Faculty of Veterinary Science, Bahaudin Zakariya University, Multan, Pakistan.
+ Hussain, Jazib. Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
+ Aslam, Jawad. Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, 38040, Pakistan.
+ Anwar, Haseeb. Department of Physiology, Government College University, Faisalabad, 38040, Pakistan. drhaseebanwar@gcuf.edu.pk.
+MeSH Subject Headings
+ Animals
+ Rats
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ Rats, Wistar
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ *Obesity
+ Biomarkers
+ Enterocytes/me [Metabolism]
+Keyword Heading
+ Dyslipidemia
+ High-fat diet
+ Insulin and leptin resistance
+ Intestinal fatty acid binding protein
+ Metabolic disorders
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The epithelial lining of the gut expresses intestinal fatty-acid binding proteins (I-FABPs), which increase in circulation and in plasma concentration during intestinal damage. From the perspective of obesity, the consumption of a diet rich in fat causes a disruption in the integrity of the gut barrier and an increase in its permeability.
+
+ HYPOTHESIS: There is an association between the expression of I-FABP in the gut and various metabolic changes induced by a high-fat (HF) diet.
+
+ METHODS: Wistar albino rats (n = 90) were divided into three groups (n = 30 per group), viz. One control and two HF diet groups (15 and 30%, respectively) were maintained for 6 weeks. Blood samples were thus collected to evaluate the lipid profile, blood glucose level and other biochemical tests. Tissue sampling was conducted to perform fat staining and immunohistochemistry.
+
+ RESULTS: HF diet-fed rats developed adiposity, insulin resistance, leptin resistance, dyslipidemia, and increased expression of I-FABP in the small intestine compared to the control group. Increased I-FABP expression in the ileal region of the intestine is correlated significantly with higher fat contents in the diet, indicating that higher I-FABP expression occurs due to increased demand of enterocytes to transport lipids, leading to metabolic alterations.
+
+ CONCLUSION: In summary, there is an association between the expression of I-FABP and HF diet-induced metabolic alterations, indicating that I-FABP can be used as a biomarker for intestinal barrier dysfunction. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs12944-023-01837-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mahmood&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Association+of+a+high-fat+diet+with+I-FABP+as+a+biomarker+of+intestinal+barrier+dysfunction+driven+by+metabolic+changes+in+Wistar+rats.&volume=22&issue=1&spage=68&epage=&date=2023&doi=10.1186%2Fs12944-023-01837-9&pmid=37237272&sid=OVID:medline
+
+<224>
+Unique Identifier
+ 37236245
+Title
+ Correlation between kisspeptin and biochemical markers in obese and non-obese women with polycystic ovary syndrome.
+Source
+ Gynecological Endocrinology. 39(1):2215869, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gao M; Tao X; Zhang Q; He W; Zhao T; Yuan T
+Author NameID
+ Zhao, Ting; ORCID: https://orcid.org/0000-0002-7254-6892
+ Yuan, Tao; ORCID: https://orcid.org/0000-0002-8886-5687
+Authors Full Name
+ Gao, Meixiu; Tao, Xinghua; Zhang, Qiong; He, Wenli; Zhao, Ting; Yuan, Tao.
+Institution
+ Gao, Meixiu. Department of Gynecology, The First People's Hospital of Yunnan Province, Yunnan, China.
+ Gao, Meixiu. Department of Gynecology, The People's Hospital of Mengzi, Mengzi, China.
+ Tao, Xinghua. The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
+ Zhang, Qiong. Yunnan University of Traditional Chinese Medicine,China.
+ He, Wenli. The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
+ Zhao, Ting. Department of Gynecology, The First People's Hospital of Yunnan Province, Yunnan, China.
+ Zhao, Ting. The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
+ Yuan, Tao. Department of Gynecology, The First People's Hospital of Yunnan Province, Yunnan, China.
+ Yuan, Tao. The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
+MeSH Subject Headings
+ Female
+ Humans
+ Anti-Mullerian Hormone
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Follicle Stimulating Hormone
+ Kisspeptins/bl [Blood]
+ *Kisspeptins
+ Luteinizing Hormone
+ Obesity/co [Complications]
+ *Obesity
+ Polycystic Ovary Syndrome/co [Complications]
+ *Polycystic Ovary Syndrome
+ Triglycerides
+ Case-Control Studies
+Keyword Heading
+ Polycystic ovary syndrome
+ biochemical index
+ insulin level
+ kisspeptin
+ obesity
+ sex hormone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction The purpose of this study was to determine the association between kisspeptin levels and obesity in patients with polycystic ovary syndrome (PCOS) or in healthy controls and to explore the correlation between levels of kisspeptin and various endocrine and metabolic indices in each group. Methods From August 2020 to December 2021, the clinical data of 78 patients with polycystic ovary syndrome and 78 healthy individuals were collected. The two groups were further divided into obese and non-obese groups based on a BMI cutoff of 25. Serum kisspeptin levels were measured using enzyme linked immunosorbent assay (ELISA). Pearson's correlation analysis was used to determine the correlation between PCOS and kisspeptin levels. Results The weight, body mass index (BMI), and waist circumference (WC), estradiol (E2), and testosterone (T) of the obese PCOS group were significantly higher than those of the study group (p < .05). WC, kisspeptin, triglycerides (TG), glucose (GLU), alanine amiotransferase (ALT), blood urea nitrogen (BUN), uric acid (UA), E2, luteinizing hormone (LH), prolactin (PRL), and T in the non-obese PCOS group were higher than those in the control group, and the difference was statistically significant (p < .05). Levels of E2 and TG in the obese PCOS group were significantly higher than those in the non-obese PCOS group (p < .05). Kisspeptin levels in the PCOS group exhibited a significant positive correlation with LH, T, and AMH levels; kisspeptin level positively correlated with T in the non-obese PCOS group and with anti-Mullerian hormone (AMH) in the obese PCOS group. Conclusion Serum kisspeptin levels are associated with hormone levels in patients with PCOS. Kisspeptin correlates with distinct biochemical indices in obese versus non-obese groups, indicating that kisspeptin may play a role in the prognostication, treatment, and clinical evaluation of patients with varying BMI.
+Registry Number/Name of Substance
+ 80497-65-0 (Anti-Mullerian Hormone). 0 (Biomarkers). 9002-68-0 (Follicle Stimulating Hormone). 0 (Kisspeptins). 9002-67-9 (Luteinizing Hormone). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1080%2f09513590.2023.2215869
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gao&issn=0951-3590&title=Gynecological+Endocrinology&atitle=Correlation+between+kisspeptin+and+biochemical+markers+in+obese+and+non-obese+women+with+polycystic+ovary+syndrome.&volume=39&issue=1&spage=2215869&epage=&date=2023&doi=10.1080%2F09513590.2023.2215869&pmid=37236245&sid=OVID:medline
+
+<225>
+Unique Identifier
+ 37231396
+Title
+ Association between lipid metabolism and periodontitis in obese patients: a cross-sectional study.
+Source
+ BMC Endocrine Disorders. 23(1):119, 2023 May 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jia R; Zhang Y; Wang Z; Hu B; Wang Z; Qiao H
+Authors Full Name
+ Jia, Ru; Zhang, Yuwei; Wang, Zhiyu; Hu, Bo; Wang, Zhenzhen; Qiao, Hu.
+Institution
+ Jia, Ru. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, No. 98 Xiwu Road, Xi'an, Shaanxi, 710004, China.
+ Jia, Ru. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
+ Zhang, Yuwei. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, No. 98 Xiwu Road, Xi'an, Shaanxi, 710004, China.
+ Wang, Zhiyu. Department of Stomatology, Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
+ Hu, Bo. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, No. 98 Xiwu Road, Xi'an, Shaanxi, 710004, China.
+ Hu, Bo. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
+ Wang, Zhenzhen. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, No. 98 Xiwu Road, Xi'an, Shaanxi, 710004, China.
+ Wang, Zhenzhen. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
+ Qiao, Hu. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, No. 98 Xiwu Road, Xi'an, Shaanxi, 710004, China. huqiao2022@163.com.
+ Qiao, Hu. Department of Orthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. huqiao2022@163.com.
+MeSH Subject Headings
+ Humans
+ *Leptin
+ Resistin
+ Cross-Sectional Studies
+ Nicotinamide Phosphoribosyltransferase
+ Overweight/co [Complications]
+ Periodontal Pocket/me [Metabolism]
+ Lipid Metabolism
+ Chronic Periodontitis/me [Metabolism]
+ *Chronic Periodontitis
+ Obesity
+ Adipokines
+ Biomarkers/me [Metabolism]
+ Cholesterol
+Keyword Heading
+ Adipokines
+ Inflammatory cytokines
+ Lipid metabolism
+ Obesity
+ Periodontitis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: To investigate the association between clinical periodontal parameters of periodontitis, serum lipid metabolism markers and adipokines' levels in patients with obesity and periodontitis.
+
+ METHODS: A total of 112 patients admitted to Hospital of Xi'an Jiaotong University were included in this study. They were divided into normal body weight group (18.5 < body mass index, BMI < 25, n = 36), overweight group (25 <= BMI < 30, n = 38), and obesity group (BMI >= 30, n = 38) accordingly. The diagnosis of periodontitis was based on the newest international classification of periodontitis. Full-mouth clinical periodontal measurements included: plaque index, periodontal pocket depth, clinical attachment level, and bleeding on probing. Gingival crevicular fluid samples were analyzed for: Interleukin-1beta, tumor necrosis factor-alpha, Interleukin-6 and C-reactive protein. Serum triglycerides, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and glycosylated hemoglobin levels were measured. Visfatin, leptin, resistin, and adiponectin levels in serum were also measured.
+
+ RESULTS: The ratio of participants without periodontitis was significantly highest in normal weight group, and the proportion of severe periodontitis (stage III and IV) was highest in obesity group. The periodontal pocket depth, clinical attachment level, and the inflammatory cytokines in gingival crevicular fluid in obesity group and overweight group were higher than those in normal body weight group. The BMI and waist-to-hip ratio (WHR) were significantly positive correlated with periodontal pocket depth and clinical attachment level. Using a Multivariate logistic regression model, periodontitis correlates to BMI, WHR, serum levels of triglyceride, total cholesterol, low density lipoprotein, and adipokines such as visfatin, leptin, and resistin.
+
+ CONCLUSIONS: Obesity is positively correlated with the aggravation of periodontitis. Obesity may aggravate the damage to periodontal tissue by regulating the secretion level of adipokines. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Leptin). 0 (Resistin). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase). 0 (Adipokines). 0 (Biomarkers). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med24&DO=10.1186%2fs12902-023-01366-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jia&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Association+between+lipid+metabolism+and+periodontitis+in+obese+patients%3A+a+cross-sectional+study.&volume=23&issue=1&spage=119&epage=&date=2023&doi=10.1186%2Fs12902-023-01366-7&pmid=37231396&sid=OVID:medline
+
+<226>
+Unique Identifier
+ 36790478
+Title
+ Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response.
+Source
+ Diabetologia. 66(5):873-883, 2023 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lutter D; Sachs S; Walter M; Kerege A; Perreault L; Kahn DE; Wolide AD; Kleinert M; Bergman BC; Hofmann SM
+Authors Full Name
+ Lutter, Dominik; Sachs, Stephan; Walter, Marc; Kerege, Anna; Perreault, Leigh; Kahn, Darcy E; Wolide, Amare D; Kleinert, Maximilian; Bergman, Bryan C; Hofmann, Susanna M.
+Institution
+ Lutter, Dominik. Computational Discovery Research, Institute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany. dominik.lutter@helmholtz-muenchen.de.
+ Lutter, Dominik. German Center for Diabetes Research (DZD), Neuherberg, Germany. dominik.lutter@helmholtz-muenchen.de.
+ Sachs, Stephan. Institute for Diabetes and Regeneration (IDR-H), Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany.
+ Walter, Marc. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Walter, Marc. Institute for Diabetes and Regeneration (IDR-H), Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany.
+ Kerege, Anna. University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
+ Perreault, Leigh. University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
+ Kahn, Darcy E. University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
+ Wolide, Amare D. Computational Discovery Research, Institute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany.
+ Wolide, Amare D. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Wolide, Amare D. Division of Metabolic Diseases, Department of Medicine, Technische Universitat Munchen (TUM), Munich, Germany.
+ Kleinert, Maximilian. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Kleinert, Maximilian. Drug Development Unit, Institute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany.
+ Kleinert, Maximilian. Group of Muscle Physiology and Metabolism, German Institute of Human Nutrition, Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
+ Bergman, Bryan C. University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
+ Hofmann, Susanna M. German Center for Diabetes Research (DZD), Neuherberg, Germany. susanna.hofmann@helmholtz-muenchen.de.
+ Hofmann, Susanna M. Institute for Diabetes and Regeneration (IDR-H), Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Neuherberg, Germany. susanna.hofmann@helmholtz-muenchen.de.
+ Hofmann, Susanna M. Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany. susanna.hofmann@helmholtz-muenchen.de.
+MeSH Subject Headings
+ Humans
+ Insulin Resistance/ge [Genetics]
+ *Insulin Resistance
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Prognosis
+ Cross-Sectional Studies
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Glucose/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Gene Expression Profiling
+Keyword Heading
+ Computational health
+ Diabetes subtypes
+ Glucose intolerance
+ Insulin resistance
+ Intermuscular adipose tissue
+ Obesity
+ Personalised medicine
+ Response to treatment prediction
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/HYPOTHESIS: Although insulin resistance often leads to type 2 diabetes mellitus, its early stages are often unrecognised, thus reducing the probability of successful prevention and intervention. Moreover, treatment efficacy is affected by the genetics of the individual. We used gene expression profiles from a cross-sectional study to identify potential candidate genes for the prediction of diabetes risk and intervention response.
+
+ METHODS: Using a multivariate regression model, we linked gene expression profiles of human skeletal muscle and intermuscular adipose tissue (IMAT) to fasting glucose levels and glucose infusion rate. Based on the expression patterns of the top predictive genes, we characterised and compared individual gene expression with clinical classifications using k-nearest neighbour clustering. The predictive potential of the candidate genes identified was validated using muscle gene expression data from a longitudinal intervention study.
+
+ RESULTS: We found that genes with a strong association with clinical measures clustered into three distinct expression patterns. Their predictive values for insulin resistance varied substantially between skeletal muscle and IMAT. Moreover, we discovered that individual gene expression-based classifications may differ from classifications based predominantly on clinical variables, indicating that participant stratification may be imprecise if only clinical variables are used for classification. Of the 15 top candidate genes, ST3GAL2, AASS, ARF1 and the transcription factor SIN3A are novel candidates for predicting a refined diabetes risk and intervention response.
+
+ CONCLUSION/INTERPRETATION: Our results confirm that disease progression and successful intervention depend on individual gene expression states. We anticipate that our findings may lead to a better understanding and prediction of individual diabetes risk and may help to develop individualised intervention strategies. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs00125-023-05874-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lutter&issn=0012-186X&title=Diabetologia&atitle=Skeletal+muscle+and+intermuscular+adipose+tissue+gene+expression+profiling+identifies+new+biomarkers+with+prognostic+significance+for+insulin+resistance+progression+and+intervention+response.&volume=66&issue=5&spage=873&epage=883&date=2023&doi=10.1007%2Fs00125-023-05874-y&pmid=36790478&sid=OVID:medline
+
+<227>
+Unique Identifier
+ 36209727
+Title
+ Triglyceride-Glucose Index Cutoff Point Is an Accurate Marker for Predicting the Prevalence of Metabolic Syndrome in Obese Caucasian Subjects.
+Source
+ Annals of Nutrition & Metabolism. 79(2):238-245, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Primo D; Izaola O; de Luis DA
+Authors Full Name
+ Primo, David; Izaola, Olatz; de Luis, Daniel A.
+Institution
+ Primo, David. Endocrinology and Nutrition Department, Hospital Clinico Universitario de Valladolid, Investigation Centre on Endocrinology and Nutrition (IEN), University of Valladolid, Valladolid, Spain.
+ Izaola, Olatz. Endocrinology and Nutrition Department, Hospital Clinico Universitario de Valladolid, Investigation Centre on Endocrinology and Nutrition (IEN), University of Valladolid, Valladolid, Spain.
+ de Luis, Daniel A. Endocrinology and Nutrition Department, Hospital Clinico Universitario de Valladolid, Investigation Centre on Endocrinology and Nutrition (IEN), University of Valladolid, Valladolid, Spain.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Male
+ Female
+ Humans
+ Adult
+ Middle Aged
+ Glucose
+ *Metabolic Syndrome
+ *Insulin Resistance
+ Blood Glucose/me [Metabolism]
+ Triglycerides
+ Cross-Sectional Studies
+ Prevalence
+ Obesity
+ Biomarkers
+Keyword Heading
+ Homeostatic model assessment
+ Metabolic syndrome
+ Obesity
+ Triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Recently, the triglyceride-glucose (TyG) index has been suggested as a surrogate insulin resistance marker. This index could act as an early screening marker in individuals with a high risk of metabolic syndrome (MS) such as obese subjects.
+
+ AIMS: The objective of this work was to detect the cutoff point of the TyG index for the diagnosis of MS according to ATPIII criteria on obese subjects and to compare with HOMA-IR.
+
+ METHODS: We conducted a cross-sectional study in 1,494 obese subjects. Measurements of adiposity parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C-reactive protein, adipokines, and the prevalence of MS were determined. The TyG index was calculated from the next equation: Ln (fasting triglycerides (mg/dL) x fasting glucose (mg/dL))/2.
+
+ RESULTS: A total of 1,494 subjects were recruited, 421 males (28.1%) and 1,073 females (71.8%), with an average age of 45.8 +/- 15.3 years (range: 29-62). A total of 677 subjects had MS (45.5%) and 817 did not show MS (54.6%). The averages of HOMA-IR and TyG index values increased as the components of MS were aggregated, and both indexes were higher in subjects with MS. The area under the curve (AUC) of the TyG index according to ATPIII criteria showed values of 0.746 (0.721-0.771; p = 0.001). The cutoff point according to the Youden index was 4.72, with sensitivity and specificity of 87% and 88.2%, respectively. For the HOMA-IR, AUC showed values of 0.682 (0.654-0.710; p = 0.01). The cutoff point was 3.23, with sensitivity and specificity of 78% and 70.1%, respectively.
+
+ CONCLUSIONS: The TyG index is more powerful for predicting MS than HOMA-IR in Caucasian obese subjects. Copyright © 2022 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Blood Glucose). 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1159%2f000526988
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Primo&issn=0250-6807&title=Annals+of+Nutrition+%26+Metabolism&atitle=Triglyceride-Glucose+Index+Cutoff+Point+Is+an+Accurate+Marker+for+Predicting+the+Prevalence+of+Metabolic+Syndrome+in+Obese+Caucasian+Subjects.&volume=79&issue=2&spage=238&epage=245&date=2023&doi=10.1159%2F000526988&pmid=36209727&sid=OVID:medline
+
+<228>
+Unique Identifier
+ 36706896
+Title
+ Association between urinary phthalate biomarker concentrations and adiposity among postmenopausal women.
+Source
+ Environmental Research. 222:115356, 2023 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vieyra G; Hankinson SE; Oulhote Y; Vandenberg LN; Tinker L; Manson JE; Shadyab AH; Thomson CA; Bao W; Allison M; Odegaard AO; Reeves KW
+Authors Full Name
+ Vieyra, Gabriela; Hankinson, Susan E; Oulhote, Youssef; Vandenberg, Laura N; Tinker, Lesley; Manson, JoAnn E; Shadyab, Aladdin H; Thomson, Cynthia A; Bao, Wei; Allison, Matthew; Odegaard, Andrew O; Reeves, Katherine W.
+Institution
+ Vieyra, Gabriela. Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
+ Hankinson, Susan E. Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
+ Oulhote, Youssef. Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
+ Vandenberg, Laura N. Department of Environmental Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
+ Tinker, Lesley. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
+ Manson, JoAnn E. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Shadyab, Aladdin H. Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
+ Thomson, Cynthia A. Department of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
+ Bao, Wei. Institute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
+ Allison, Matthew. Department of Family Medicine, Division of Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
+ Odegaard, Andrew O. Department of Epidemiology and Biostatistics, University of California Irvine, Irvine, CA, USA.
+ Reeves, Katherine W. Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA. Electronic address: kwreeves@umass.edu.
+MeSH Subject Headings
+ Humans
+ Female
+ *Adiposity
+ *Postmenopause
+ Obesity
+ Biomarkers/me [Metabolism]
+ Intra-Abdominal Fat/me [Metabolism]
+Keyword Heading
+ Biomarkers
+ Phthalates
+ Postmenopausal
+ Subcutaneous adiposity
+ Visceral adiposity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a leading risk factor for chronic diseases, potentially related to excess abdominal adiposity. Phthalates are environmental chemicals that have been suggested to act as obesogens, driving obesity risk. For the associations between phthalates and adiposity, prior studies have focused primarily on body mass index. We hypothesize that more refined measures of adiposity and fat distribution may provide greater insights into these associations given the role of central adiposity in chronic disease risk.
+
+ OBJECTIVES: To evaluate associations between urinary phthalate biomarkers and both visceral and subcutaneous adipose tissue (VAT and SAT) among postmenopausal women enrolled in the Women's Health Initiative (WHI).
+
+ METHODS: We included 1125 WHI participants with available, coincident measurements of urinary phthalate biomarkers (baseline, year 3) and VAT and SAT (baseline, year 3, year 6). VAT and SAT measurements were estimated from DXA scans. Multilevel mixed-effects models estimated the prospective associations between urinary phthalate biomarkers at baseline and VAT and SAT three years later.
+
+ RESULTS: In multivariable adjusted models, we observed positive associations between some phthalate biomarkers, including the sum of di-isobutyl phthalate (SIGMADiBP) biomarkers, MCNP, and SIGMADEHP, with VAT three years later. For example, we observed positive associations between concentrations of SIGMADiBP and VAT (Q4 vs Q1 beta = 7.15, 95% CI -1.76-16.06; Q3 vs Q1 beta = 10.94, 95% CI 3.55-18.33). Associations were generally attenuated but remained significant after additional adjustment for SAT. MBzP was positively associated with SAT. Other phthalate biomarkers investigated (MEP, MCOP, MCPP, SIGMADBP) were not significantly associated with VAT or SAT.
+
+ DISCUSSION: Based on robust measures of adiposity, this study provides supportive evidence that higher urinary concentrations of select phthalate compounds were associated with higher VAT levels over time in postmenopausal women. Efforts to replicate these findings are needed. Copyright © 2023 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 6O7F7IX66E (phthalic acid). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.envres.2023.115356
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vieyra&issn=0013-9351&title=Environmental+Research&atitle=Association+between+urinary+phthalate+biomarker+concentrations+and+adiposity+among+postmenopausal+women.&volume=222&issue=&spage=115356&epage=&date=2023&doi=10.1016%2Fj.envres.2023.115356&pmid=36706896&sid=OVID:medline
+
+<229>
+Unique Identifier
+ 36630488
+Title
+ Protein Markers of Diabetes Discovered in an African American Cohort.
+Source
+ Diabetes. 72(4):532-543, 2023 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen ZZ; Gao Y; Keyes MJ; Deng S; Mi M; Farrell LA; Shen D; Tahir UA; Cruz DE; Ngo D; Benson MD; Robbins JM; Correa A; Wilson JG; Gerszten RE
+Author NameID
+ Gerszten, Robert E; ORCID: https://orcid.org/0000-0002-6767-7687
+Authors Full Name
+ Chen, Zsu-Zsu; Gao, Yan; Keyes, Michelle J; Deng, Shuliang; Mi, Michael; Farrell, Laurie A; Shen, Dongxiao; Tahir, Usman A; Cruz, Daniel E; Ngo, Debby; Benson, Mark D; Robbins, Jeremy M; Correa, Adolfo; Wilson, James G; Gerszten, Robert E.
+Institution
+ Chen, Zsu-Zsu. Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA.
+ Chen, Zsu-Zsu. Harvard School of Medicine, Boston, MA.
+ Gao, Yan. Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS.
+ Keyes, Michelle J. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Deng, Shuliang. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Mi, Michael. Harvard School of Medicine, Boston, MA.
+ Mi, Michael. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Farrell, Laurie A. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Shen, Dongxiao. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Tahir, Usman A. Harvard School of Medicine, Boston, MA.
+ Tahir, Usman A. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Cruz, Daniel E. Harvard School of Medicine, Boston, MA.
+ Cruz, Daniel E. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Ngo, Debby. Harvard School of Medicine, Boston, MA.
+ Ngo, Debby. Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Benson, Mark D. Harvard School of Medicine, Boston, MA.
+ Benson, Mark D. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Robbins, Jeremy M. Harvard School of Medicine, Boston, MA.
+ Robbins, Jeremy M. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Correa, Adolfo. Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS.
+ Wilson, James G. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Gerszten, Robert E. Harvard School of Medicine, Boston, MA.
+ Gerszten, Robert E. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
+ Gerszten, Robert E. Broad Institute of MIT and Harvard, Boston, MA.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Black or African American
+ Risk Factors
+ Obesity
+ Biomarkers
+Abstract
+ Proteomics has been used to study type 2 diabetes, but the majority of available data are from White participants. Here, we extend prior work by analyzing a large cohort of self-identified African Americans in the Jackson Heart Study (n = 1,313). We found 325 proteins associated with incident diabetes after adjusting for age, sex, and sample batch (false discovery rate q < 0.05) measured using a single-stranded DNA aptamer affinity-based method on fasting plasma samples. A subset was independent of established markers of diabetes development pathways, such as adiposity, glycemia, and/or insulin resistance, suggesting potential novel biological processes associated with disease development. Thirty-six associations remained significant after additional adjustments for BMI, fasting plasma glucose, cholesterol levels, hypertension, statin use, and renal function. Twelve associations, including the top associations of complement factor H, formimidoyltransferase cyclodeaminase, serine/threonine-protein kinase 17B, and high-mobility group protein B1, were replicated in a meta-analysis of two self-identified White cohorts-the Framingham Heart Study and the Malmo Diet and Cancer Study-supporting the generalizability of these biomarkers. A selection of these diabetes-associated proteins also improved risk prediction. Thus, we uncovered both novel and broadly generalizable associations by studying a diverse population, providing a more complete understanding of the diabetes-associated proteome. Copyright © 2023 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Meta-Analysis. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.2337%2fdb22-0710
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=0012-1797&title=Diabetes&atitle=Protein+Markers+of+Diabetes+Discovered+in+an+African+American+Cohort.&volume=72&issue=4&spage=532&epage=543&date=2023&doi=10.2337%2Fdb22-0710&pmid=36630488&sid=OVID:medline
+
+<230>
+Unique Identifier
+ 35973801
+Title
+ Prospective Observational Study of N-terminal Pro-Brain Natriuretic Peptide Levels in Obese and Nonobese Women during Pregnancy.
+Source
+ American Journal of Perinatology. 40(5):467-474, 2023 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Denoble AE; Moyett JM; Goldstein SA; Ward CC; Truong T; Erkanli A; James AH; Grotegut CA
+Author NameID
+ Denoble, Anna E; ORCID: https://orcid.org/0000-0001-9767-114X
+Authors Full Name
+ Denoble, Anna E; Moyett, Julia M; Goldstein, Sarah A; Ward, Cary C; Truong, Tracy; Erkanli, Alaattin; James, Andra H; Grotegut, Chad A.
+Institution
+ Denoble, Anna E. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Health System, Durham, North Carolina.
+ Moyett, Julia M. Duke University School of Medicine, Duke University, Durham, North Carolina.
+ Goldstein, Sarah A. Division of Cardiology, Department of Medicine, Duke University Health System, Durham, North Carolina.
+ Ward, Cary C. Division of Cardiology, Department of Medicine, Duke University Health System, Durham, North Carolina.
+ Truong, Tracy. Department of Biostatistics and Bioinformatics, Duke University Health System, Durham, North Carolina.
+ Erkanli, Alaattin. Department of Biostatistics and Bioinformatics, Duke University Health System, Durham, North Carolina.
+ James, Andra H. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Health System, Durham, North Carolina.
+ Grotegut, Chad A. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wake Forest Baptist Health System, Winston-Salem, North Carolina.
+MeSH Subject Headings
+ Pregnancy
+ Humans
+ Female
+ Obesity/ep [Epidemiology]
+ *Obesity
+ *Natriuretic Peptide, Brain
+ Peptide Fragments
+ Comorbidity
+ Biomarkers
+Abstract
+ OBJECTIVE: N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of ventricular dysfunction, varies by body mass index (BMI) outside of pregnancy. This study aimed to determine whether obesity affects NT-proBNP levels in pregnancy.
+
+ STUDY DESIGN: This was a prospective observational study of healthy pregnant people in the third trimester (3TM) and postpartum (PP). Patients were excluded if they had significant medical comorbidities or if their fetuses had anomalies, growth restriction or aneuploidy. NT-proBNP was measured at 28 weeks (3TM), predelivery (PD), 1 to 2 days PP (immediate postpartum [IPP]), and 4 to 6 weeks PP (delayed postpartum [DPP]). LogNT-proBNP levels were analyzed using linear mixed effects models, including BMI < or >=30, time, and time-by-BMI interactions.
+
+ RESULTS: Fifty-five people (28 [51%] with BMI >= 30 and 27 [49%] with BMI < 30) were enrolled. A greater proportion of obese than nonobese subjects developed hypertensive disorders of pregnancy (50 vs. 15%, p = 0.010) and obese patients had higher systolic blood pressures at all time points (p < 0.05). NT-proBNP levels (median [interquartile range] in pg/mL) were 18 (6-28) versus 26 (17-48) at 3TM, 16 (3-38) versus 43 (21-60) at PD, 58 (20-102) versus 63 (38-155) at IPP, and 33 (27-56) versus 23 (8-42) at DPP for obese compared with nonobese patients. In linear mixed effects models, logNT-proBNP was lower in obese patients at 3TM (beta = -0.89 [95% confidence interval, CI: -1.51, -0.26]) and PD (beta = -1.05 [95% CI: -1.72, -0.38]). The logNT-proBNP trends over time differed by BMI category, with higher values in obese patients at both PP time points compared with the 3TM (IPP beta = 1.24 [95% CI: 0.75, 1.73]; DPP beta = 1.08 [95% CI: 0.52, 1.63]), but only IPP for nonobese patients (beta = 0.87 [95% CI: 0.36, 1.38]).
+
+ CONCLUSION: Obese patients had lower NT-proBNP levels than nonobese patients during pregnancy but not PP. The prolonged PP elevation in NT-proBNP in obese patients suggests that their PP cardiac recovery may be more prolonged.
+
+ KEY POINTS: . NT-proBNP levels are lower in obese than nonobese patients during pregnancy.. . Levels remain elevated in obese, but not nonobese, patients up to 4 to 6 weeks' postpartum.. . A lower threshold for concern regarding NT-proBNP levels may be needed in obese pregnant people.. Copyright Thieme. All rights reserved.
+Registry Number/Name of Substance
+ 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain). 0 (Peptide Fragments). 0 (Biomarkers).
+Publication Type
+ Observational Study. Journal Article. Research Support, Non-U.S. Gov't. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1055%2fa-1925-1532
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Denoble&issn=0735-1631&title=American+Journal+of+Perinatology&atitle=Prospective+Observational+Study+of+N-terminal+Pro-Brain+Natriuretic+Peptide+Levels+in+Obese+and+Nonobese+Women+during+Pregnancy.&volume=40&issue=5&spage=467&epage=474&date=2023&doi=10.1055%2Fa-1925-1532&pmid=35973801&sid=OVID:medline
+
+<231>
+Unique Identifier
+ 36905117
+Title
+ Associations of atrial natriuretic peptide with measures of insulin and adipose depots.
+Source
+ Physiological Reports. 11(5):e15625, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Couch CA; Fowler LA; Parcha V; Arora P; Gower BA
+Author NameID
+ Couch, Catharine A; ORCID: https://orcid.org/0000-0002-4568-8609
+Authors Full Name
+ Couch, Catharine A; Fowler, Lauren A; Parcha, Vibhu; Arora, Pankaj; Gower, Barbara A.
+Institution
+ Couch, Catharine A. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Fowler, Lauren A. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Parcha, Vibhu. Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Arora, Pankaj. Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Gower, Barbara A. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+MeSH Subject Headings
+ Male
+ Adult
+ Humans
+ Female
+ *Atrial Natriuretic Factor
+ Insulin
+ *Diabetes Mellitus, Type 2
+ Natriuretic Peptides
+ Obesity
+ Peptide Fragments
+ Biomarkers
+Keyword Heading
+ adipose tissue
+ insulin
+ natriuretic peptides
+ race
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Low concentrations of natriuretic peptides (NPs) have been associated with greater risk for Type 2 diabetes (T2D). African American individuals (AA) have lower NP levels and are disproportionately burdened by T2D. The purpose of this study was to test the hypothesis that higher post-challenge insulin in AA adults is associated with lower plasma N-terminal pro-atrial natriuretic peptide (NT-proANP). A secondary purpose was to explore associations between NT-proANP and adipose depots. Participants were 112 AA and European American (EA) adult men and women. Measures of insulin were obtained from an oral glucose tolerance test and hyperinsulinemic-euglycemic glucose clamp. Total and regional adipose depots were measured from DXA and MRI. Multiple linear regression analysis was used to assess associations of NT-proANP with measures of insulin and adipose depots. Lower NT-proANP concentrations in AA participants was not independent of 30-min insulin area under the curve (AUC). NT-proANP was inversely associated with 30-min insulin AUC in AA participants, and with fasting insulin and HOMA-IR in EA participants. Thigh subcutaneous adipose tissue and perimuscular adipose tissue were positively associated with NT-proANP in EA participants. Higher post-challenge insulin may contribute to lower ANP concentrations in AA adults. Copyright © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
+Registry Number/Name of Substance
+ 85637-73-6 (Atrial Natriuretic Factor). 0 (Insulin). 0 (Natriuretic Peptides). 0 (Peptide Fragments). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.14814%2fphy2.15625
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Couch&issn=2051-817X&title=Physiological+Reports&atitle=Associations+of+atrial+natriuretic+peptide+with+measures+of+insulin+and+adipose+depots.&volume=11&issue=5&spage=e15625&epage=&date=2023&doi=10.14814%2Fphy2.15625&pmid=36905117&sid=OVID:medline
+
+<232>
+Unique Identifier
+ 36999465
+Title
+ Correlation between smoking and serum lipoprotein-associated phospholipase A2 level in overweight and obese men.
+Original Title
+ A2 .
+Source
+ Zhong Nan da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. 48(2):191-197, 2023 Feb 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhou H; Zhao L
+Authors Full Name
+ Zhou, Hui; Zhao, Linlin.
+Institution
+ Zhou, Hui. Health Management Center, Third Xiangya Hospital, Central South University, Changsha 410013, China. zhouhui68346@163.com.
+ Zhao, Linlin. Health Management Center, Third Xiangya Hospital, Central South University, Changsha 410013, China. zllin7@126.com.
+MeSH Subject Headings
+ Humans
+ Male
+ 1-Alkyl-2-acetylglycerophosphocholine Esterase
+ Overweight
+ *Cardiovascular Diseases
+ *Tobacco Smoke Pollution
+ Biomarkers
+ Obesity
+ Smoking
+ Risk Factors
+Keyword Heading
+ lipoprotein-associated phospholipase A2
+ obesity
+ overweight
+ smoking
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a vaso-specific inflammatory marker that exacerbates atherosclerotic through inflammatory responses. It can be used to predict the occurrence of adverse cardiovascular events and to assess the residual risk of cardiovascular diseases. This study aims to investigate the correlation between smoking and serum Lp-PLA2 levels in overweight and obese men, and to provide evidence for preventing the cardiovascular diseases.
+
+ METHODS: Male subjects, who participated in health examination at the Health Management Center, Third Xiangya Hospital, Central South University from May 1, 2020 to April 30, 2021, were selected. The smoking status and other information were collected by the Self-test Scale of Physical Examination. According to the smoking status, they were divided into a never-smoking group, a current smoking group, a quit smoking group and a passive smoking group. According to the daily smoking amount, the current smoking subjects were divided into a <10 cigarettes group, a 10 to 20 cigarettes group, a 21 to 30 cigarettes group, and a >30 cigarettes group. According to the smoking years, the current smoking subjects were divided into a <5 years group, a 5 to 10 years group, a 11 to 20 years group, and a >20 years group.Serum Lp-PLA2 levels and other clinical indexes in different smoking groups were measured and compared, the correlation between smoking and serum Lp-PLA2 levels in overweight and obese men was analyzed by logistic regression analysis.
+
+ RESULTS: Serum Lp-PLA2 levels were significantly different between the never-smoking group and the current smoking group (P<0.05). Logistic regression analysis showed that, before adjusting other influencing factors and in terms of smoking status, the current smoking group (OR=1.81, 95% CI 1.27 to 2.58, P<0.01) and the quit smoking group (OR=2.09, 95% CI 1.12 to 3.90, P<0.05) were positively correlated with serum Lp-PLA2 levels compared with the never-smoking group, while the passive smoking group had no correlation with serum Lp-PLA2 levels (OR=1.27, 95% CI 0.59 to 2.73, P>0.05). In terms of daily smoking amount, the 10 to 20 cigarettes group (OR=2.09, 95% CI 1.40 to 3.12, P<0.001) and the 21 to 30 cigarettes group (OR=1.98, 95% CI 1.22 to 3.20, P<0.01) were positively correlated with serum Lp-PLA2 levels compared with the never-smoking group, while the <10 cigarettes group (OR=1.45, 95% CI 0.81 to 2.60, P>0.05) and the >30 cigarettes group (OR=1.17, 95% CI 0.60 to 2.28, P>0.05) had no correlation with serum Lp-PLA2 levels. In terms of smoking years, the 5 to 10 years group (OR=1.94, 95% CI 1.07 to 3.53, P<0.05), the 11 to 20 years group (OR=2.06, 95% CI 1.33 to 3.18, P<0.01), and the >20 years group (OR=1.66, 95% CI 1.11 to 2.47, P<0.05) were positively correlated with serum Lp-PLA2 levels compared with the never-smoking group, while the <5 years group had no correlation with serum Lp-PLA2 levels (OR=1.12, 95% CI 0.38 to 3.33, P>0.05). After adjusting for age and other indicators, the correlation between smoking years and serum Lp-PLA2 levels was the same as before adjustment among the above smoking groups, except that the correlation between the smoking 5 to 10 years group and serum Lp-PLA2 levels was not significant (OR=1.77, 95% CI 0.95 to 3.29, P>0.05).
+
+ CONCLUSIONS: Smoking is correlated with serum Lp-PLA2 levels in overweight and obese men.
+Other Abstract
+ Publisher
+ : A2(lipoprotein-associated phospholipase A2,Lp-PLA2) , , Lp-PLA2 , : 2020 5 1 2021 4 30 , <10 10~20 21~30 >30 ; <5 5~10 11~20 >20 Lp-PLA2 , logistic Lp-PLA2 : Lp-PLA2 (P<0.05) Logistic : , , , (OR=1.81,95% CI:1.27~2.58,P<0.01) (OR=2.09,95% CI:1.12~3.90,P<0.05) Lp-PLA2 , Lp-PLA2 (OR=1.27,95% CI:0.59~2.73,P>0.05); , ,10~20 (OR=2.09,95% CI:1.40~3.12,P<0.001) 21~30 (OR=1.98,95% CI:1.22~3.20,P<0.01) Lp-PLA2 , <10 (OR=1.45,95% CI:0.81~2.60,P>0.05) >30 (OR=1.17,95% CI:0.60~2.28,P>0.05) Lp-PLA2 ; , ,5~10 (OR=1.94,95% CI:1.07~3.53,P<0.05) 11~20 (OR=2.06,95% CI:1.33~3.18,P<0.01) >20 (OR=1.66,95% CI:1.11~2.47,P<0.05) Lp-PLA2 , <5 Lp-PLA2 (OR=1.12,95% CI:0.38~3.33,P>0.05) , 5~10 Lp-PLA2 (OR=1.77,95% CI:0.95~3.29,P>0.05), Lp-PLA2 : Lp-PLA2 .
+ Language: Chinese
+Registry Number/Name of Substance
+ EC 3-1-1-47 (1-Alkyl-2-acetylglycerophosphocholine Esterase). 0 (Tobacco Smoke Pollution). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.11817%2fj.issn.1672-7347.2023.210457
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhou&issn=1672-7347&title=Zhong+Nan+da+Xue+Xue+Bao.+Yi+Xue+Ban+%3D+Journal+of+Central+South+University.+Medical+Sciences&atitle=A2+.&volume=48&issue=2&spage=191&epage=197&date=2023&doi=10.11817%2Fj.issn.1672-7347.2023.210457&pmid=36999465&sid=OVID:medline
+
+<233>
+Unique Identifier
+ 36999303
+Title
+ Association between device-measured stepping behaviors and cardiometabolic health markers in middle-aged women: The Australian Longitudinal Study on Women's Health.
+Source
+ Scandinavian Journal of Medicine & Science in Sports. 33(8):1384-1398, 2023 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wei L; Ahmadi MN; Chan HW; Chastin S; Hamer M; Mishra GD; Stamatakis E
+Author NameID
+ Wei, Le; ORCID: https://orcid.org/0000-0002-8831-9803
+ Ahmadi, Matthew N; ORCID: https://orcid.org/0000-0002-3115-338X
+ Chan, Hsiu-Wen; ORCID: https://orcid.org/0000-0003-1545-0488
+ Chastin, Sebastien; ORCID: https://orcid.org/0000-0003-1421-9348
+ Hamer, Mark; ORCID: https://orcid.org/0000-0002-8726-7992
+ Mishra, Gita D; ORCID: https://orcid.org/0000-0001-9610-5904
+ Stamatakis, Emmanuel; ORCID: https://orcid.org/0000-0001-7323-3225
+Authors Full Name
+ Wei, Le; Ahmadi, Matthew N; Chan, Hsiu-Wen; Chastin, Sebastien; Hamer, Mark; Mishra, Gita D; Stamatakis, Emmanuel.
+Institution
+ Wei, Le. Charles Perkins Centre, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
+ Ahmadi, Matthew N. Charles Perkins Centre, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
+ Chan, Hsiu-Wen. School of Public Health, The University of Queensland, Brisbane, Australia.
+ Chastin, Sebastien. School of Health and Life Science, Glasgow Caledonian University, Glasgow, UK.
+ Chastin, Sebastien. Department of Movement and Sports Science, Ghent University, Ghent, Belgium.
+ Hamer, Mark. Division of Surgery and Interventional Science, Institute of Sport Exercise and Health, University College London, London, UK.
+ Mishra, Gita D. School of Public Health, The University of Queensland, Brisbane, Australia.
+ Stamatakis, Emmanuel. Charles Perkins Centre, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
+MeSH Subject Headings
+ Middle Aged
+ Humans
+ Female
+ Longitudinal Studies
+ Cross-Sectional Studies
+ Risk Factors
+ Australia
+ *Women's Health
+ Obesity
+ *Cardiovascular Diseases
+ Biomarkers
+Keyword Heading
+ accelerometry
+ epidemiology
+ intensity
+ physical activity
+ stair
+ walking
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The associations between different types and contexts of stepping behaviors and cardiometabolic (CM) health markers are unclear. This study aimed to examine the associations of daily total, walking, stair, incidental and purposeful steps with cardiometabolic risk. A total of 943 women (mean age +/- SD = 44.1 +/- 1.6 years) from the Australian Longitudinal Study on Women's Health (ALSWH) were included in this cross-sectional study. Daily total, walking, stair, incidental, and purposeful steps were measured using thigh-worn accelerometry. Outcomes comprised of CM markers of adiposity, blood pressure, resting heart rate, lipids, glycaemia, and the composite CM score. We used generalized linear modeling and multiple linear regression to assess the associations. We observed that all stepping behaviors were beneficial to CM health, for example, compared to the lowest quartile (Q1), the change of the composite CM score across low to high quartile of purposeful steps was -0.12 (Q2, 95% CI: -0.41, 0.17), -0.16 (Q3, -0.46, 0.14), and -0.36 (Q4, -0.66, -0.05). Stair steps showed linear associations with blood pressure and adiposity biomarkers, for example, the change of quartile of waist circumference was -1.45 cm (Q2, -4.35, 1.44), -3.56 cm (Q3, -6.52, -0.60), and -7.08 cm (Q4, -10.31, -3.86). Peak 30-min walking intensity showed independent association with adiposity biomarkers (p linear < 0.001 and p = 0.002 for waist circumference and BMI, respectively). Our study showed that all stepping forms were beneficial to CM health. Higher stair steps and peak 30-min walking cadence were associated with a steep decline of adiposity biomarkers. Purpose ful steps showed more consistent associations with CM biomarkers than incidental steps. Copyright © 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1111%2fsms.14363
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wei&issn=0905-7188&title=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&atitle=Association+between+device-measured+stepping+behaviors+and+cardiometabolic+health+markers+in+middle-aged+women%3A+The+Australian+Longitudinal+Study+on+Women%27s+Health.&volume=33&issue=8&spage=1384&epage=1398&date=2023&doi=10.1111%2Fsms.14363&pmid=36999303&sid=OVID:medline
+
+<234>
+Unique Identifier
+ 36130209
+Title
+ Blood transcriptomic biomarkers of alcohol consumption and cardiovascular disease risk factors: the Framingham Heart Study.
+Source
+ Human Molecular Genetics. 32(4):649-658, 2023 01 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ma J; Huang A; Yan K; Li Y; Sun X; Joehanes R; Huan T; Levy D; Liu C
+Author NameID
+ Ma, Jiantao; ORCID: https://orcid.org/0000-0001-7478-7203
+ Liu, Chunyu; ORCID: https://orcid.org/0000-0002-9160-0153
+Authors Full Name
+ Ma, Jiantao; Huang, Allen; Yan, Kaiyu; Li, Yi; Sun, Xianbang; Joehanes, Roby; Huan, Tianxiao; Levy, Daniel; Liu, Chunyu.
+Institution
+ Ma, Jiantao. Division of Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.
+ Ma, Jiantao. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
+ Huang, Allen. Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02142, USA.
+ Yan, Kaiyu. Department of Biostatistics, Boston University, Boston, MA 02118, USA.
+ Li, Yi. Department of Biostatistics, Boston University, Boston, MA 02118, USA.
+ Sun, Xianbang. Department of Biostatistics, Boston University, Boston, MA 02118, USA.
+ Joehanes, Roby. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
+ Huan, Tianxiao. Department of Ophthalmology and Visual Sciences, University of Massachusetts Medical School, Worcester, MA 01605, USA.
+ Levy, Daniel. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
+ Levy, Daniel. Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
+ Liu, Chunyu. Department of Biostatistics, Boston University, Boston, MA 02118, USA.
+ Liu, Chunyu. Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
+MeSH Subject Headings
+ Humans
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/ge [Genetics]
+ Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases
+ Transcriptome
+ Cross-Sectional Studies
+ Alcohol Drinking/ae [Adverse Effects]
+ Alcohol Drinking/ge [Genetics]
+ Hypertension/ge [Genetics]
+ *Hypertension
+ Risk Factors
+ Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Obesity/co [Complications]
+ Diabetes Mellitus/ep [Epidemiology]
+ Diabetes Mellitus/ge [Genetics]
+ *Diabetes Mellitus
+ Longitudinal Studies
+ Biomarkers
+Abstract
+ BACKGROUND: The relations of alcohol consumption and gene expression remain to be elucidated.
+
+ MATERIALS AND METHODS: We examined cross-sectional associations between alcohol consumption and whole blood derived gene expression levels and between alcohol-associated genes and obesity, hypertension, and diabetes in 5531 Framingham Heart Study (FHS) participants.
+
+ RESULTS: We identified 25 alcohol-associated genes. We further showed cross-sectional associations of 16 alcohol-associated genes with obesity, nine genes with hypertension, and eight genes with diabetes at P < 0.002. For example, we observed decreased expression of PROK2 (beta = -0.0018; 95%CI: -0.0021, -0.0007; P = 6.5e - 5) and PAX5 (beta = -0.0014; 95%CI: -0.0021, -0.0007; P = 6.5e - 5) per 1 g/day increase in alcohol consumption. Consistent with our previous observation on the inverse association of alcohol consumption with obesity and positive association of alcohol consumption with hypertension, we found that PROK2 was positively associated with obesity (OR = 1.42; 95%CI: 1.17, 1.72; P = 4.5e - 4) and PAX5 was negatively associated with hypertension (OR = 0.73; 95%CI: 0.59, 0.89; P = 1.6e - 3). We also observed that alcohol consumption was positively associated with expression of ABCA13 (beta = 0.0012; 95%CI: 0.0007, 0.0017; P = 1.3e - 6) and ABCA13 was positively associated with diabetes (OR = 2.57; 95%CI: 1.73, 3.84; P = 3.5e - 06); this finding, however, was inconsistent with our observation of an inverse association between alcohol consumption and diabetes.
+
+ CONCLUSIONS: We showed strong cross-sectional associations between alcohol consumption and expression levels of 25 genes in FHS participants. Nonetheless, complex relationships exist between alcohol-associated genes and CVD risk factors. Copyright © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1093%2fhmg%2fddac237
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ma&issn=0964-6906&title=Human+Molecular+Genetics&atitle=Blood+transcriptomic+biomarkers+of+alcohol+consumption+and+cardiovascular+disease+risk+factors%3A+the+Framingham+Heart+Study.&volume=32&issue=4&spage=649&epage=658&date=2023&doi=10.1093%2Fhmg%2Fddac237&pmid=36130209&sid=OVID:medline
+
+<235>
+Unique Identifier
+ 36728523
+Title
+ Antimullerian hormone and adiposity across midlife among women in Project Viva.
+Source
+ Menopause. 30(3):247-253, 2023 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Francis EC; Oken E; Hivert MF; Rifas-Shiman SL; Chavarro JE; Perng W
+Authors Full Name
+ Francis, Ellen C; Oken, Emily; Hivert, Marie-France; Rifas-Shiman, Sheryl L; Chavarro, Jorge E; Perng, Wei.
+Institution
+ Francis, Ellen C. From the Lifecourse Epidemiology of Adiposity and Diabetes Center, Colorado School of Public Health, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO.
+ Rifas-Shiman, Sheryl L. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Landmark Center, Boston, MA.
+MeSH Subject Headings
+ Female
+ Humans
+ *Adiposity
+ *Anti-Mullerian Hormone
+ Biomarkers
+ Obesity/co [Complications]
+ Prospective Studies
+ Middle Aged
+Abstract
+ OBJECTIVE: This study aimed to examine the association of antimullerian hormone (AMH) with concurrent and prospective measures of adiposity during approximately 9 years of follow-up.
+
+ METHODS: Participants were 697 parous women from the Project Viva prebirth cohort without polycystic ovarian syndrome. We measured AMH at approximately 3 years postpartum (baseline). Outcomes were weight, body mass index (BMI), and waist circumference assessed at baseline, 4, and 9 years later; % body fat was assessed by bioimpedance at the 4- and 9-year visit. We used linear mixed-effect models including all outcome time points and accounting for age across follow-up and hormonal contraception prescription. In an additional model, we further adjusted for height.
+
+ RESULTS: Median AMH was 1.97 ng/mL (interquartile range, 0.83-4.36 ng/mL), 29.1% had AMH <1.0 ng/mL, and mean age at AMH measurement was 36.7 years (SD, 4.9 y; range, 20-48 y). AMH was inversely associated with average weight, BMI, and waist circumference over follow-up. In age-adjusted models, women with AMH <1.0 versus >=1.0 ng/mL were 4.92 kg (95% CI, 2.01-7.82 kg) heavier, had a 2.51 cm (95% CI, 0.12-4.89 cm) greater waist circumference, and a 1.46 kg/m 2 (95% CI, 0.44-2.48 kg/m 2 ) greater BMI across the 9 years of follow-up. Findings were similar after covariate adjustment and when AMH was modeled continuously. AMH was also inversely associated with higher fat mass %; however, the CI crossed the null.
+
+ CONCLUSION: Low AMH at baseline was associated with greater adiposity concurrently and across approximately 9 years of follow-up. Whether low AMH is a useful marker of metabolic risk across midlife requires further research. Copyright © 2023 by The North American Menopause Society.
+Registry Number/Name of Substance
+ 80497-65-0 (Anti-Mullerian Hormone). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1097%2fGME.0000000000002143
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Francis&issn=1072-3714&title=Menopause&atitle=Antimullerian+hormone+and+adiposity+across+midlife+among+women+in+Project+Viva.&volume=30&issue=3&spage=247&epage=253&date=2023&doi=10.1097%2FGME.0000000000002143&pmid=36728523&sid=OVID:medline
+
+<236>
+Unique Identifier
+ 37224770
+Title
+ Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease.
+Source
+ EBioMedicine. 92:104620, 2023 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Darci-Maher N; Alvarez M; Arasu UT; Selvarajan I; Lee SHT; Pan DZ; Miao Z; Das SS; Kaminska D; Ord T; Benhammou JN; Wabitsch M; Pisegna JR; Mannisto V; Pietilainen KH; Laakso M; Sinsheimer JS; Kaikkonen MU; Pihlajamaki J; Pajukanta P
+Authors Full Name
+ Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T; Pan, David Z; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Ord, Tiit; Benhammou, Jihane N; Wabitsch, Martin; Pisegna, Joseph R; Mannisto, Ville; Pietilainen, Kirsi H; Laakso, Markku; Sinsheimer, Janet S; Kaikkonen, Minna U; Pihlajamaki, Jussi; Pajukanta, Paivi.
+Institution
+ Darci-Maher, Nicholas. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA.
+ Alvarez, Marcus. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA.
+ Arasu, Uma Thanigai. A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
+ Selvarajan, Ilakya. A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
+ Lee, Seung Hyuk T. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA.
+ Pan, David Z. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA.
+ Miao, Zong. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA.
+ Das, Sankha Subhra. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA.
+ Kaminska, Dorota. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, USA.
+ Ord, Tiit. A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
+ Benhammou, Jihane N. Vatche and Tamar Manoukian Division of Digestive Diseases, and Gastroenterology, Hepatology and Parenteral Nutrition, David Geffen School of Medicine at UCLA and VA Greater Los Angeles HCS, Los Angeles, USA.
+ Wabitsch, Martin. Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.
+ Pisegna, Joseph R. Department of Medicine and Human Genetics, Division of Gastroenterology, Hepatology and Parenteral Nutrition, David Geffen School of Medicine at UCLA and VA Greater Los Angeles HCS, Los Angeles, USA.
+ Mannisto, Ville. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
+ Pietilainen, Kirsi H. Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Obesity Center, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
+ Laakso, Markku. Institute of Clinical Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.
+ Sinsheimer, Janet S. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA; Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, USA; Department of Computational Medicine, David Geffen School of Medicine at UCLA, Los Angeles, USA.
+ Kaikkonen, Minna U. A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
+ Pihlajamaki, Jussi. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland.
+ Pajukanta, Paivi. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, USA; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, USA; Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, USA. Electronic address: ppajukanta@mednet.ucla.edu.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Genome-Wide Association Study
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Liver/me [Metabolism]
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ Adipogenesis
+ Dual-tissue transcriptomics screening
+ Liver histology
+ Non-alcoholic fatty liver disease
+ Obesity
+ Serum biomarkers
+ cis regulatory variants
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ectopic fat accumulation into the liver.
+
+ METHODS: To identify adipose-based mechanisms and potential serum biomarker candidates (SBCs) for NAFLD, we utilise dual-tissue RNA-sequencing (RNA-seq) data in adipose tissue and liver, paired with histology-based NAFLD diagnosis, from the same individuals in a cohort of obese individuals. We first scan for genes that are differentially expressed (DE) for NAFLD in obese individuals' subcutaneous adipose tissue but not in their liver; encode proteins secreted to serum; and show preferential adipose expression. Then the identified genes are filtered to key adipose-origin NAFLD genes by best subset analysis, knockdown experiments during human preadipocyte differentiation, recombinant protein treatment experiments in human liver HepG2 cells, and genetic analysis.
+
+ FINDINGS: We discover a set of genes, including 10 SBCs, that may modulate NAFLD pathogenesis by impacting adipose tissue function. Based on best subset analysis, we further follow-up on two SBCs CCDC80 and SOD3 by knockdown in human preadipocytes and subsequent differentiation experiments, which show that they modulate crucial adipogenesis genes, LPL, SREBPF1, and LEP. We also show that treatment of the liver HepG2 cells with the CCDC80 and SOD3 recombinant proteins impacts genes related to steatosis and lipid processing, including PPARA, NFE2L2, and RNF128. Finally, utilizing the adipose NAFLD DE gene cis-regulatory variants associated with serum triglycerides (TGs) in extensive genome-wide association studies (GWASs), we demonstrate a unidirectional effect of serum TGs on NAFLD with Mendelian Randomization (MR) analysis. We also demonstrate that a single SNP regulating one of the SBC genes, rs2845885, produces a significant MR result by itself. This supports the conclusion that genetically regulated adipose expression of the NAFLD DE genes may contribute to NAFLD through changes in serum TG levels.
+
+ INTERPRETATION: Our results from the dual-tissue transcriptomics screening improve the understanding of obesity-related NAFLD by providing a targeted set of 10 adipose tissue-active genes as new serum biomarker candidates for the currently grossly underdiagnosed fatty liver disease.
+
+ FUNDING: The work was supported by NIH grants R01HG010505 and R01DK132775. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The KOBS study (J. P.) was supported by the Finnish Diabetes Research Foundation, Kuopio University Hospital Project grant (EVO/VTR grants 2005-2019), and the Academy of Finland grant (Contract no. 138006). This study was funded by the European Research Council under the European Union's Horizon 2020 research and innovation program (Grant No. 802825 to M. U. K.). K. H. P. was funded by the Academy of Finland (grant numbers 272376, 266286, 314383, and 335443), the Finnish Medical Foundation, Gyllenberg Foundation, Novo Nordisk Foundation (grant numbers NNF10OC1013354, NNF17OC0027232, and NNF20OC0060547), Finnish Diabetes Research Foundation, Finnish Foundation for Cardiovascular Research, University of Helsinki, and Helsinki University Hospital and Government Research Funds. I. S. was funded by the Instrumentarium Science Foundation. Personal grants to U. T. A. were received from the Matti and Vappu Maukonen Foundation, Ella och Georg Ehrnrooths Stiftelse and the Finnish Foundation for Cardiovascular Research. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.ebiom.2023.104620
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Darci-Maher&issn=2352-3964&title=EBioMedicine&atitle=Cross-tissue+omics+analysis+discovers+ten+adipose+genes+encoding+secreted+proteins+in+obesity-related+non-alcoholic+fatty+liver+disease.&volume=92&issue=&spage=104620&epage=&date=2023&doi=10.1016%2Fj.ebiom.2023.104620&pmid=37224770&sid=OVID:medline
+
+<237>
+Unique Identifier
+ 36221008
+Title
+ Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women.
+Source
+ Diabetologia. 66(2):321-335, 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mutie PM; Pomares-Milan H; Atabaki-Pasdar N; Coral D; Fitipaldi H; Tsereteli N; Tajes JF; Franks PW; Giordano GN
+Author NameID
+ Mutie, Pascal M; ORCID: https://orcid.org/0000-0003-2626-1703
+ Franks, Paul W; ORCID: http://orcid.org/0000-0002-0520-7604
+Authors Full Name
+ Mutie, Pascal M; Pomares-Milan, Hugo; Atabaki-Pasdar, Naeimeh; Coral, Daniel; Fitipaldi, Hugo; Tsereteli, Neli; Tajes, Juan Fernandez; Franks, Paul W; Giordano, Giuseppe N.
+Institution
+ Mutie, Pascal M. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden.
+ Pomares-Milan, Hugo. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden.
+ Atabaki-Pasdar, Naeimeh. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden.
+ Coral, Daniel. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden.
+ Fitipaldi, Hugo. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden.
+ Tsereteli, Neli. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden.
+ Tajes, Juan Fernandez. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden.
+ Franks, Paul W. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden. paul.franks@med.lu.se.
+ Franks, Paul W. Harvard T.H. Chan School of Public Health, Boston, MA, USA. paul.franks@med.lu.se.
+ Giordano, Giuseppe N. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Lund, Sweden.
+MeSH Subject Headings
+ Humans
+ Female
+ Male
+ *Diabetes Mellitus, Type 2
+ *Coronary Artery Disease
+ Adiposity
+ Body Mass Index
+ Risk Factors
+ Obesity
+ Cholesterol, LDL/me [Metabolism]
+ Biomarkers
+ *Cardiovascular Diseases
+ Mendelian Randomization Analysis
+Keyword Heading
+ Cardiometabolic
+ Causal
+ Mendelian randomisation
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/HYPOTHESIS: Excess adiposity is differentially associated with increased risk of cardiometabolic disease in men and women, according to observational studies. Causal inference studies largely assume a linear relationship between BMI and cardiometabolic outcomes, which may not be the case. In this study, we investigated the shapes of the causal relationships between BMI and cardiometabolic diseases and risk factors. We further investigated sex differences within the causal framework.
+
+ METHODS: To assess causal relationships between BMI and the outcomes, we used two-stage least-squares Mendelian randomisation (MR), with a polygenic risk score for BMI as the instrumental variable. To elucidate the shapes of the causal relationships, we used a non-linear MR fractional polynomial method, and used piecewise MR to investigate threshold relationships and confirm the shapes.
+
+ RESULTS: BMI was associated with type 2 diabetes (OR 3.10; 95% CI 2.73, 3.53), hypertension (OR 1.53; 95% CI 1.44, 1.62) and coronary artery disease (OR 1.20; 95% CI 1.08, 1.33), but not chronic kidney disease (OR 1.08; 95% CI 0.67, 1.72) or stroke (OR 1.08; 95% CI 0.92, 1.28). The data suggest that these relationships are non-linear. For cardiometabolic risk factors, BMI was positively associated with glucose, HbA1c, triacylglycerol levels and both systolic and diastolic BP. BMI had an inverse causal relationship with total cholesterol, LDL-cholesterol and HDL-cholesterol. The data suggest a non-linear causal relationship between BMI and BP and other biomarkers (p<0.001) except lipoprotein A. The piecewise MR results were consistent with the fractional polynomial results. The causal effect of BMI on coronary artery disease, total cholesterol and LDL-cholesterol was different in men and women, but this sex difference was only significant for LDL-cholesterol after controlling for multiple testing (p<0.001). Further, the causal effect of BMI on coronary artery disease varied by menopause status in women.
+
+ CONCLUSIONS/INTERPRETATION: We describe the shapes of causal effects of BMI on cardiometabolic diseases and risk factors, and report sex differences in the causal effects of BMI on LDL-cholesterol. We found evidence of non-linearity in the causal effect of BMI on diseases and risk factor biomarkers. Reducing excess adiposity is highly beneficial for health, but there is greater need to consider biological sex in the management of adiposity. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Cholesterol, LDL). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs00125-022-05811-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mutie&issn=0012-186X&title=Diabetologia&atitle=Investigating+the+causal+relationships+between+excess+adiposity+and+cardiometabolic+health+in+men+and+women.&volume=66&issue=2&spage=321&epage=335&date=2023&doi=10.1007%2Fs00125-022-05811-5&pmid=36221008&sid=OVID:medline
+
+<238>
+Unique Identifier
+ 36377121
+Title
+ Metabolic profile predicts incident cancer: A large-scale population study in the UK Biobank.
+Source
+ Metabolism: Clinical & Experimental. 138:155342, 2023 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ahmed M; Makinen VP; Lumsden A; Boyle T; Mulugeta A; Lee SH; Olver I; Hypponen E
+Authors Full Name
+ Ahmed, Muktar; Makinen, Ville-Petteri; Lumsden, Amanda; Boyle, Terry; Mulugeta, Anwar; Lee, Sang Hong; Olver, Ian; Hypponen, Elina.
+Institution
+ Ahmed, Muktar. Australian Centre for Precision Health, University of South Australia, Adelaide, SA, Australia; Department of Epidemiology, Faculty of Public Health, Jimma University Institute of Health, Jimma, Ethiopia; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
+ Makinen, Ville-Petteri. Australian Centre for Precision Health, University of South Australia, Adelaide, SA, Australia; Computational Systems Biology Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
+ Lumsden, Amanda. Australian Centre for Precision Health, University of South Australia, Adelaide, SA, Australia; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
+ Boyle, Terry. Australian Centre for Precision Health, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia; UniSA Allied Health & Human Performance, University of South Australia, Adelaide, SA, Australia.
+ Mulugeta, Anwar. Australian Centre for Precision Health, University of South Australia, Adelaide, SA, Australia; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
+ Lee, Sang Hong. Australian Centre for Precision Health, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia; UniSA Allied Health & Human Performance, University of South Australia, Adelaide, SA, Australia.
+ Olver, Ian. School of Psychology, Faculty of Health and Medical Sciences, University of Adelaide, Australia.
+ Hypponen, Elina. Australian Centre for Precision Health, University of South Australia, Adelaide, SA, Australia; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia. Electronic address: Elina.Hypponen@unisa.edu.au.
+MeSH Subject Headings
+ Humans
+ Risk Factors
+ *Biological Specimen Banks
+ Obesity/co [Complications]
+ Biomarkers
+ Metabolome
+ *Liver Neoplasms
+ United Kingdom/ep [Epidemiology]
+Keyword Heading
+ Biomarkers
+ Hormone-sensitive cancers
+ Metabolic subgroup profile
+ Self-organizing map
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Analyses to predict the risk of cancer typically focus on single biomarkers, which do not capture their complex interrelations. We hypothesized that the use of metabolic profiles may provide new insights into cancer prediction.
+
+ METHODS: We used information from 290,888 UK Biobank participants aged 37 to 73 years at baseline. Metabolic subgroups were defined based on clustering of biochemical data using an artificial neural network approach and examined for their association with incident cancers identified through linkage to cancer registry. In addition, we evaluated associations between 38 individual biomarkers and cancer risk.
+
+ RESULTS: In total, 21,973 individuals developed cancer during the follow-up (median 3.87 years, interquartile range [IQR] = 2.03-5.58). Compared to the metabolically favorable subgroup (IV), subgroup III (defined as "high BMI, C-reactive protein & cystatin C") was associated with a higher risk of obesity-related cancers (hazard ratio [HR] = 1.26, 95 % CI = 1.21 to 1.32) and hematologic-malignancies (e.g., lymphoid leukemia: HR = 1.83, 95%CI = 1.44 to 2.33). Subgroup II ("high triglycerides & liver enzymes") was strongly associated with liver cancer risk (HR = 5.70, 95%CI = 3.57 to 9.11). Analysis of individual biomarkers showed a positive association between testosterone and greater risks of hormone-sensitive cancers (HR per SD higher = 1.32, 95%CI = 1.23 to 1.44), and liver cancer (HR = 2.49, 95%CI =1.47 to 4.24). Many liver tests were individually associated with a greater risk of liver cancer with the strongest association observed for gamma-glutamyl transferase (HR = 2.40, 95%CI = 2.19 to 2.65).
+
+ CONCLUSIONS: Metabolic profile in middle-to-older age can predict cancer incidence, in particular risk of obesity-related cancer, hematologic malignancies, and liver cancer. Elevated values from liver tests are strong predictors for later risk of liver cancer. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.metabol.2022.155342
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ahmed&issn=0026-0495&title=Metabolism%3A+Clinical+%26+Experimental&atitle=Metabolic+profile+predicts+incident+cancer%3A+A+large-scale+population+study+in+the+UK+Biobank.&volume=138&issue=&spage=155342&epage=&date=2023&doi=10.1016%2Fj.metabol.2022.155342&pmid=36377121&sid=OVID:medline
+
+<239>
+Unique Identifier
+ 36260527
+Title
+ The Association of Inflammatory Factors With Peripheral Neuropathy: The Study of Women's Health Across the Nation.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 108(4):962-970, 2023 03 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sanders WM; Harlow SD; Ylitalo KR; Lange-Maia BS; Leis AM; McConnell DS; Karvonen-Gutierrez CA
+Author NameID
+ Sanders, Wade M; ORCID: https://orcid.org/0000-0002-9759-5543
+ Ylitalo, Kelly R; ORCID: https://orcid.org/0000-0002-1474-6781
+ Lange-Maia, Brittney S; ORCID: https://orcid.org/0000-0001-6642-7558
+ Leis, Aleda M; ORCID: https://orcid.org/0000-0003-2867-9062
+ Karvonen-Gutierrez, Carrie A; ORCID: https://orcid.org/0000-0002-1950-5397
+Authors Full Name
+ Sanders, Wade M; Harlow, Sioban D; Ylitalo, Kelly R; Lange-Maia, Brittney S; Leis, Aleda M; McConnell, Daniel S; Karvonen-Gutierrez, Carrie A.
+Institution
+ Sanders, Wade M. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
+ Harlow, Sioban D. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
+ Ylitalo, Kelly R. Department of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX.
+ Lange-Maia, Brittney S. Rush Alzheimer's Disease Center and Department of Preventative Medicine, Rush University Medical Center, Chicago, IL.
+ Leis, Aleda M. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
+ McConnell, Daniel S. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
+ Karvonen-Gutierrez, Carrie A. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
+MeSH Subject Headings
+ Humans
+ Female
+ Middle Aged
+ Aged
+ C-Reactive Protein/me [Metabolism]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/co [Complications]
+ *Metabolic Syndrome
+ Inflammation/co [Complications]
+ Women's Health
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ *Diabetes Mellitus
+ Biomarkers
+ Peripheral Nervous System Diseases/ep [Epidemiology]
+ Peripheral Nervous System Diseases/et [Etiology]
+ *Peripheral Nervous System Diseases
+ Fibrinogen/an [Analysis]
+ Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases
+ Risk Factors
+Keyword Heading
+ CRP
+ fibrinogen
+ inflammation
+ metabolic syndrome
+ peripheral neuropathy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Previous work has focused on the role of diabetes in peripheral neuropathy (PN), but PN often occurs before, and independently from, diabetes. This study measures the association of cardiometabolic and inflammatory factor with PN, independent of diabetes.
+
+ METHODS: Study of Women's Health Across the Nation participants (n = 1910), ages 60 to 73 (mean 65.6) were assessed for PN by symptom questionnaire and monofilament testing at the 15th follow-up visit (V15). Anthropometric measures and biomarkers were measured at study baseline approximately 20 years prior, and C-reactive protein (CRP) and fibrinogen were measured longitudinally. Log-binomial regression was used to model the association between metabolic syndrome (MetS), obesity (>=35 body mass index), CRP, and fibrinogen with PN, adjusting for sociodemographic and health behavior measures.
+
+ RESULTS: Baseline MetS [prevalence ratio (PR) 1.79, 95% CI (1.45, 2.20)], obesity [PR 2.08 (1.65, 2.61)], median CRP [PR 1.32 per log(mg/dL), (1.20, 1.45)], and mean fibrinogen (PR 1.28 per 100 mg/dL, (1.09, 1.50)] were associated with PN symptoms at V15. After excluding participants with baseline diabetes or obesity, MetS [PR 1.59 (1.17, 2.14)] and CRP [PR 1.19 per log(mg/dL), (1.06, 1.35)] remained statistically significantly associated with PN. There was a negative interaction between MetS and obesity, and the association between these conditions and PN was mediated by CRP.
+
+ CONCLUSIONS: Cardiometabolic factors and inflammation are significantly associated with PN, independent of diabetes and obesity. CRP mediates the relationship of both obesity and MetS with PN, suggesting an etiological role of inflammation in PN in this sample. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Biomarkers). 9001-32-5 (Fibrinogen).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1210%2fclinem%2fdgac612
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sanders&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=The+Association+of+Inflammatory+Factors+With+Peripheral+Neuropathy%3A+The+Study+of+Women%27s+Health+Across+the+Nation.&volume=108&issue=4&spage=962&epage=970&date=2023&doi=10.1210%2Fclinem%2Fdgac612&pmid=36260527&sid=OVID:medline
+
+<240>
+Unique Identifier
+ 36621902
+Title
+ Effect of behavioral weight-loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial.
+Source
+ Obesity. 31(2):338-349, 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Collins KA; Kraus WE; Rogers RJ; Hauser ER; Lang W; Jiang R; Schelbert EB; Huffman KM; Jakicic JM
+Author NameID
+ Collins, Katherine A; ORCID: https://orcid.org/0000-0001-9712-8980
+Authors Full Name
+ Collins, Katherine A; Kraus, William E; Rogers, Renee J; Hauser, Elizabeth R; Lang, Wei; Jiang, Rong; Schelbert, Erik B; Huffman, Kim M; Jakicic, John M.
+Institution
+ Collins, Katherine A. Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
+ Kraus, William E. Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
+ Kraus, William E. Division of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA.
+ Rogers, Renee J. Wondr Health, Dallas, Texas, USA.
+ Hauser, Elizabeth R. Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
+ Hauser, Elizabeth R. Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
+ Hauser, Elizabeth R. Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, North Carolina, USA.
+ Lang, Wei. Center on Aging and Mobility, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
+ Jiang, Rong. Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
+ Schelbert, Erik B. School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
+ Schelbert, Erik B. Minneapolis Heart Institute East, Saint Paul, Minnesota, USA.
+ Huffman, Kim M. Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
+ Huffman, Kim M. Division of Rheumatology and Immunology, Duke University School of Medicine, Durham, North Carolina, USA.
+ Jakicic, John M. Division of Physical Activity and Weight Management, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
+MeSH Subject Headings
+ Adult
+ Humans
+ *Weight Reduction Programs
+ *Insulin Resistance
+ Obesity/th [Therapy]
+ Obesity/me [Metabolism]
+ Overweight/th [Therapy]
+ Overweight/me [Metabolism]
+ Weight Loss
+ Biomarkers
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+Abstract
+ OBJECTIVE: This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12-month behavioral weight-loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers.
+
+ METHODS: Participants (N = 374) were randomized to either diet alone (DIET), diet plus 150 min/wk of prescribed moderate-intensity physical activity (DIET + PA150), or diet plus 250 min/wk of prescribed moderate-intensity physical activity (DIET + PA250). Biomarker concentrations were determined using nuclear magnetic resonance spectroscopy. Mixed models assessed for a time effect, group effect, or group by time interaction.
+
+ RESULTS: All groups significantly improved body weight (time: p < 0.0001), Lipoprotein Insulin Resistance Index score (time: p < 0.0001), Diabetes Risk Index score (time: p < 0.0001), branched-chain amino acid concentration (time: p < 0.0001), and GlycA concentration (time: p < 0.0001), with no group effect or group by time interactions.
+
+ CONCLUSIONS: All intervention groups prompted a notable beneficial change among biomarkers of insulin resistance and cardiometabolic health. However, the addition of at least moderate-intensity physical activity to a diet-only intervention did not provide any additional benefit. These findings highlight that an average weight loss of approximately 10% profoundly impacts biomarkers of insulin resistance and cardiometabolic disease in adults with overweight or obesity. Copyright © 2023 The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2foby.23618
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Collins&issn=1930-7381&title=Obesity&atitle=Effect+of+behavioral+weight-loss+program+on+biomarkers+of+cardiometabolic+disease+risk%3A+Heart+Health+Study+randomized+trial.&volume=31&issue=2&spage=338&epage=349&date=2023&doi=10.1002%2Foby.23618&pmid=36621902&sid=OVID:medline
+
+<241>
+Unique Identifier
+ 36670060
+Title
+ Secondary bile acids improve risk prediction for non-invasive identification of mild liver fibrosis in nonalcoholic fatty liver disease.
+Source
+ Alimentary Pharmacology & Therapeutics. 57(8):872-885, 2023 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu AN; Xu CF; Liu YR; Sun DQ; Jiang L; Tang LJ; Zhu PW; Chen SD; Liu WY; Wang XD; Targher G; Byrne CD; Wong VW; Fu J; Su MM; Loomba R; Zheng MH; Ni Y
+Author NameID
+ Targher, Giovanni; ORCID: https://orcid.org/0000-0002-4325-3900
+ Wong, Vincent Wai-Sun; ORCID: https://orcid.org/0000-0003-2215-9410
+ Loomba, Rohit; ORCID: https://orcid.org/0000-0002-4845-9991
+ Zheng, Ming-Hua; ORCID: https://orcid.org/0000-0003-4984-2631
+ Ni, Yan; ORCID: https://orcid.org/0000-0003-1779-7266
+Authors Full Name
+ Liu, A-Na; Xu, Cui-Fang; Liu, Ya-Ru; Sun, Dan-Qin; Jiang, Ling; Tang, Liang-Jie; Zhu, Pei-Wu; Chen, Sui-Dan; Liu, Wen-Yue; Wang, Xiao-Dong; Targher, Giovanni; Byrne, Christopher D; Wong, Vincent Wai-Sun; Fu, Junfen; Su, Ming-Ming; Loomba, Rohit; Zheng, Ming-Hua; Ni, Yan.
+Institution
+ Liu, A-Na. National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
+ Xu, Cui-Fang. National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
+ Liu, Ya-Ru. National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
+ Sun, Dan-Qin. Department of Nephrology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
+ Sun, Dan-Qin. Affiliated Wuxi Clinical College of Nantong University, Wuxi, China.
+ Jiang, Ling. National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
+ Tang, Liang-Jie. NAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
+ Zhu, Pei-Wu. Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
+ Chen, Sui-Dan. Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
+ Liu, Wen-Yue. Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
+ Wang, Xiao-Dong. Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
+ Targher, Giovanni. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy.
+ Byrne, Christopher D. Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton & University of Southampton, Southampton General Hospital, Southampton, UK.
+ Wong, Vincent Wai-Sun. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
+ Wong, Vincent Wai-Sun. State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
+ Fu, Junfen. National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
+ Su, Ming-Ming. Clinical Mass Spectrometry Innovation Center, Shanghai Keyi Biotechnology Co., Ltd., Shanghai, China.
+ Loomba, Rohit. NAFLD Research Center, Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA.
+ Zheng, Ming-Hua. NAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
+ Zheng, Ming-Hua. Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
+ Zheng, Ming-Hua. Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
+ Ni, Yan. National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
+MeSH Subject Headings
+ Adult
+ Male
+ Humans
+ Female
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Bile Acids and Salts
+ Liver Cirrhosis/co [Complications]
+ Inflammation/co [Complications]
+ Biomarkers
+ Obesity/co [Complications]
+ Liver/pa [Pathology]
+Keyword Heading
+ liver fibrosis
+ nonalcoholic fatty liver disease
+ risk prediction
+ secondary bile acids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Dysregulated bile acid (BA) metabolism has been linked to steatosis, inflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD).
+
+ AIM: To determine whether circulating BA levels accurately stage liver fibrosis in NAFLD.
+
+ METHODS: We recruited 550 Chinese adults with biopsy-proven NAFLD and varying levels of fibrosis. Ultra-performance liquid chromatography coupled with tandem mass spectrometry was performed to quantify 38 serum BAs.
+
+ RESULTS: Compared to those without fibrosis, patients with mild fibrosis (stage F1) had significantly higher levels of secondary BAs, and increased diastolic blood pressure (DBP), alanine aminotransferase (ALT), body mass index, and waist circumstance (WC). The combination of serum BAs with WC, DBP, ALT, or Homeostatic Model Assessment for Insulin Resistance performed well in identifying mild fibrosis, in men and women, and in those with/without obesity, with AUROCs 0.80, 0.88, 0.75 and 0.78 in the training set (n = 385), and 0.69, 0.80, 0.61 and 0.69 in the testing set (n = 165), respectively. In comparison, the combination of BAs and clinical/biochemical biomarkers performed less well in identifying significant fibrosis (F2-4). In women and in non-obese subjects, AUROCs were 0.75 and 0.71 in the training set, 0.65 and 0.66 in the validation set, respectively. However, these AUROCs were higher than those observed for the fibrosis-4 index, NAFLD fibrosis score, and Hepamet fibrosis score.
+
+ CONCLUSIONS: Secondary BA levels were significantly increased in NAFLD, especially in those with mild fibrosis. The combination of serum BAs and clinical/biochemical biomarkers for identifying mild fibrosis merits further assessment. Copyright © 2023 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1111%2fapt.17362
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=0269-2813&title=Alimentary+Pharmacology+%26+Therapeutics&atitle=Secondary+bile+acids+improve+risk+prediction+for+non-invasive+identification+of+mild+liver+fibrosis+in+nonalcoholic+fatty+liver+disease.&volume=57&issue=8&spage=872&epage=885&date=2023&doi=10.1111%2Fapt.17362&pmid=36670060&sid=OVID:medline
+
+<242>
+Unique Identifier
+ 36525799
+Title
+ Identification of potential biomarkers and metabolic insights for gestational diabetes prevention: A review of evidence contrasting gestational diabetes versus weight loss studies that may direct future nutritional metabolomics studies. [Review]
+Source
+ Nutrition. 107:111898, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Heath H; Degreef K; Rosario R; Smith M; Mitchell I; Pilolla K; Phelan S; Brito A; La Frano MR
+Authors Full Name
+ Heath, Hannah; Degreef, Kelsey; Rosario, Rodrigo; Smith, MaryKate; Mitchell, Isabel; Pilolla, Kari; Phelan, Suzanne; Brito, Alex; La Frano, Michael R.
+Institution
+ Heath, Hannah. Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California.
+ Degreef, Kelsey. Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California.
+ Rosario, Rodrigo. Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California.
+ Smith, MaryKate. Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California.
+ Mitchell, Isabel. Department of Biological Sciences, California Polytechnic State University, San Luis Obispo, California.
+ Pilolla, Kari. Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California; Center for Health Research, California Polytechnic State University, San Luis Obispo, California.
+ Phelan, Suzanne. Center for Health Research, California Polytechnic State University, San Luis Obispo, California; Department of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, California.
+ Brito, Alex. Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; World-Class Research Center "Digital Biodesign and Personalized Health Care," I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
+ La Frano, Michael R. Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California; Center for Health Research, California Polytechnic State University, San Luis Obispo, California; Cal Poly Metabolomics Service Center, California Polytechnic State University, San Luis Obispo, California.
+MeSH Subject Headings
+ Pregnancy
+ Female
+ Humans
+ Diabetes, Gestational/pc [Prevention & Control]
+ Diabetes, Gestational/ep [Epidemiology]
+ *Diabetes, Gestational
+ Overweight
+ *Insulin Resistance
+ Obesity/pc [Prevention & Control]
+ Obesity/ep [Epidemiology]
+ Weight Loss
+ Biomarkers
+Keyword Heading
+ Biomarkers
+ Gestational diabetes
+ Metabolites
+ Metabolomics
+ Nutrition
+ Nutritional metabolomics
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Gestational diabetes mellitus (GDM) significantly increases maternal health risks and adverse effects for the offspring. Observational studies suggest that weight loss before pregnancy may be a promising GDM prevention method. Still, biochemical pathways linking preconception weight changes with subsequent development of GDM among women who are overweight or obese remain unclear. Metabolomic assessment is a powerful approach for understanding the global biochemical pathways linking preconception weight changes and subsequent GDM. We hypothesize that many of the alterations of metabolite levels associated with GDM will change in one direction in GDM studies but will change in the opposite direction in studies focusing on lifestyle interventions for weight loss. The present review summarizes available evidence from 21 studies comparing women with GDM with healthy participants and 12 intervention studies that investigated metabolite changes that occurred during weight loss using caloric restriction and behavioral interventions. We discuss 15 metabolites, including amino acids, lipids, amines, carbohydrates, and carbohydrate derivatives. Of particular note are the altered levels of branched-chain amino acids, alanine, palmitoleic acid, lysophosphatidylcholine 18:1, and hypoxanthine because of their mechanistic links to insulin resistance and weight change. Mechanisms that may explain how these metabolite modifications contribute to GDM development in those who are overweight or obese are proposed, including insulin resistance pathways. Future nutritional metabolomics preconception intervention studies in overweight or obese are necessary to investigate whether weight loss through lifestyle intervention can reduce GDM occurrence in association with these metabolite alterations and to test the value of these metabolites as potential diagnostic biomarkers of GDM development. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.nut.2022.111898
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Heath&issn=0899-9007&title=Nutrition&atitle=Identification+of+potential+biomarkers+and+metabolic+insights+for+gestational+diabetes+prevention%3A+A+review+of+evidence+contrasting+gestational+diabetes+versus+weight+loss+studies+that+may+direct+future+nutritional+metabolomics+studies.&volume=107&issue=&spage=111898&epage=&date=2023&doi=10.1016%2Fj.nut.2022.111898&pmid=36525799&sid=OVID:medline
+
+<243>
+Unique Identifier
+ 36795242
+Title
+ The effect of Mediterranean diet on inflammatory biomarkers and components of metabolic syndrome in adolescent girls.
+Source
+ Journal of Endocrinological Investigation. 46(10):1995-2004, 2023 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Asoudeh F; Fallah M; Aminianfar A; Djafarian K; Shirzad N; Clark CCT; Larijani B; Esmaillzadeh A
+Authors Full Name
+ Asoudeh, F; Fallah, M; Aminianfar, A; Djafarian, K; Shirzad, N; Clark, C C T; Larijani, B; Esmaillzadeh, A.
+Institution
+ Asoudeh, F. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Fallah, M. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
+ Aminianfar, A. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
+ Aminianfar, A. Research Center for Biochemistry and Nutrition in Metabolic Disease, Kashan University of Medical Sciences, Kashan, Iran.
+ Djafarian, K. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Shirzad, N. Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
+ Clark, C C T. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, UK.
+ Larijani, B. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Esmaillzadeh, A. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran. a-esmaillzadeh@tums.ac.ir.
+ Esmaillzadeh, A. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. a-esmaillzadeh@tums.ac.ir.
+ Esmaillzadeh, A. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. a-esmaillzadeh@tums.ac.ir.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Female
+ Humans
+ Adolescent
+ *Metabolic Syndrome
+ *Diet, Mediterranean
+ Biomarkers
+ Obesity
+ C-Reactive Protein/me [Metabolism]
+ Body Mass Index
+ Blood Glucose
+Keyword Heading
+ Adolescents
+ Diet
+ Inflammation
+ Mediterranean diet
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The prevalence of obesity and metabolic syndrome (MetS) during childhood and adolescence is rising significantly worldwide. Previous studies have shown that following a healthy dietary pattern, like the Mediterranean diet (MD), might be an efficacious approach for the prevention and management of MetS during childhood. In the present study, we aimed to examine the effect of MD on inflammatory markers and components of MetS among adolescent girls with MetS.
+
+ METHODS: This randomized controlled clinical trial was conducted on 70 girl adolescents with metabolic syndrome. Patients in the intervention group followed a prescribed MD, while participants in the control group received dietary advice according to the food pyramid. The length of intervention was 12 weeks. Participants ' dietary intakes were evaluated using three 1-day food records throughout the study. Anthropometric measures, inflammatory markers, systolic and diastolic blood pressure, and hematological factors were assessed at the baseline and end of the trial. An intention-to-treat approach was taken into account for the statistical analysis.
+
+ RESULTS: After 12 weeks, participants in the intervention group had lower weight (Ptime*group <= 0/001), body mass index (BMI) (Ptime*group <= 0/001), and waist circumference (WC) (Ptime*group <= 0/001) compared with those in the control group. In addition, MD resulted in a significantly reduced systolic blood pressure compared to the those in the control group (Ptime*group <= 0/001). In terms of metabolic variables, MD led to a significant decrease in fasting blood glucose (FBS) (Ptime*group <= 0/001), triglycerides (TG) (Ptime*group <= 0/001), low-density lipoprotein (LDL) (Ptime*group <= 0/001), homeostatic model assessment of insulin resistance (HOMA-IR) (Ptime*group = 0/02) and a meaningful increase in serum levels of high-density lipoprotein (HDL) (Ptime*group <= 0/001). In addition, adherence to the MD resulted in a significant reduction in serum levels of inflammatory markers including Interleukin 6 (IL-6) (Ptime*group = 0/02) and high-sensitivity C-reactive protein (hs-CRP) (Ptime*group = 0/02). However, no significant effect was seen on serum levels of tumor necrosis factor alpha (TNF-alpha) (Ptime*group = 0/43).
+
+ CONCLUSION: Overall, the findings of the present study revealed that consumption of MD for 12 weeks resulted in a favorable effect on anthropometric measures, components of MetS, as well as on some inflammatory biomarkers. Copyright © 2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). 0 (Blood Glucose).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs40618-023-02027-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Asoudeh&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=The+effect+of+Mediterranean+diet+on+inflammatory+biomarkers+and+components+of+metabolic+syndrome+in+adolescent+girls.&volume=46&issue=10&spage=1995&epage=2004&date=2023&doi=10.1007%2Fs40618-023-02027-1&pmid=36795242&sid=OVID:medline
+
+<244>
+Unique Identifier
+ 36085441
+Title
+ Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence.
+Source
+ Pediatric Obesity. 18(1):e12977, 2023 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Qureshi F; Aris IM; Rifas-Shiman SL; Perng W; Oken E; Rich-Edwards J; Cardenas A; Baccarelli AA; Enlow MB; Belfort MB; Tiemeier H
+Author NameID
+ Qureshi, Farah; ORCID: https://orcid.org/0000-0002-9092-8085
+ Aris, Izzuddin M; ORCID: https://orcid.org/0000-0002-9239-7476
+ Perng, Wei; ORCID: https://orcid.org/0000-0001-8552-6850
+Authors Full Name
+ Qureshi, Farah; Aris, Izzuddin M; Rifas-Shiman, Sheryl L; Perng, Wei; Oken, Emily; Rich-Edwards, Janet; Cardenas, Andres; Baccarelli, Andrea A; Enlow, Michelle Bosquet; Belfort, Mandy B; Tiemeier, Henning.
+Institution
+ Qureshi, Farah. Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
+ Aris, Izzuddin M. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
+ Rifas-Shiman, Sheryl L. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
+ Perng, Wei. Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
+ Oken, Emily. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
+ Oken, Emily. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
+ Rich-Edwards, Janet. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
+ Rich-Edwards, Janet. Division of Women's Health, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
+ Cardenas, Andres. Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California, USA.
+ Cardenas, Andres. Center for Computational Biology, University of California Berkeley, Berkeley, California, USA.
+ Baccarelli, Andrea A. Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, New York, USA.
+ Enlow, Michelle Bosquet. Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts, USA.
+ Enlow, Michelle Bosquet. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
+ Belfort, Mandy B. Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
+ Tiemeier, Henning. Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
+MeSH Subject Headings
+ Child
+ Infant, Newborn
+ Male
+ Infant
+ Adolescent
+ Female
+ Humans
+ *Adiposity
+ *Fetal Blood
+ Obesity
+ Body Mass Index
+ Leukocytes
+ Telomere
+ Biomarkers
+Keyword Heading
+ BMI peak
+ BMI rebound
+ adiposity
+ body mass index
+ developmental origins of disease
+ telomeres
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Leukocyte telomere length (LTL) may be a biomarker for chronic disease susceptibility, but no work has tested this hypothesis directly. Our study investigated associations of LTL at birth with markers of adiposity growth that are linked with cardiometabolic health later in life.
+
+ METHODS: Participants were 375 children in Project Viva (48% female, 71% White). Body mass index (BMI) trajectories from birth to 18 years were tracked using repeated measures of BMI collected in physical examinations and via medical records, then used to predict age (months) and magnitude (kg/m2 ) of BMI peak and rebound. LTL was measured from cord blood via duplex quantitative PCR. A binary variable indicating LTL shorter than the reference population average was the primary exposure.
+
+ RESULTS: LTL was unrelated to BMI at peak or rebound, but associations were apparent with the timing of BMI growth milestones. Short LTL was related to a later age of peak for females (beta = 0.99, 95% CI = 0.16, 1.82; psex interaction = 0.015) and an earlier age of rebound for both males and females (betacombined = -5.26, 95% CI = -9.44, -1.08).
+
+ CONCLUSION: LTL at birth may be an early biomarker of altered adiposity growth. Newborn telomere biology may shed new insight into the developmental origins of health and disease. Copyright © 2022 World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1111%2fijpo.12977
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Qureshi&issn=2047-6302&title=Pediatric+Obesity&atitle=Associations+of+cord+blood+leukocyte+telomere+length+with+adiposity+growth+from+infancy+to+adolescence.&volume=18&issue=1&spage=e12977&epage=&date=2023&doi=10.1111%2Fijpo.12977&pmid=36085441&sid=OVID:medline
+
+<245>
+Unique Identifier
+ 34757198
+Title
+ Longitudinal Changes in MR Elastography-based Biomarkers in Obese Patients Treated with Bariatric Surgery.
+Source
+ Clinical Gastroenterology & Hepatology. 21(1):220-222.e3, 2023 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li J; Allen AM; Shah VH; Manduca A; Ehman RL; Yin M
+Corporate Author
+ NAFLD MR Imaging Research Group
+Authors Full Name
+ Li, Jiahui; Allen, Alina M; Shah, Vijay H; Manduca, Armando; Ehman, Richard L; Yin, Meng.
+Institution
+ Li, Jiahui. Department of Radiology, Mayo Clinic, Rochester, Minnesota.
+ Allen, Alina M. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
+ Shah, Vijay H. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
+ Manduca, Armando. Department of Radiology, Mayo Clinic, Rochester, Minnesota.
+ Ehman, Richard L. Department of Radiology, Mayo Clinic, Rochester, Minnesota.
+ Yin, Meng. Department of Radiology, Mayo Clinic, Rochester, Minnesota. Electronic address: Yin.Meng@mayo.edu.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease
+ *Elasticity Imaging Techniques
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+ Obesity/pa [Pathology]
+ Bariatric Surgery/mt [Methods]
+ *Bariatric Surgery
+ Biomarkers
+ Inflammation/pa [Pathology]
+ Liver/dg [Diagnostic Imaging]
+ Liver/pa [Pathology]
+ Liver Cirrhosis/dg [Diagnostic Imaging]
+ Liver Cirrhosis/pa [Pathology]
+Abstract
+ Obesity-related chronic inflammation contributes to nonalcoholic fatty liver disease (NAFLD) progression in obese patients (body mass index [BMI] >30 kg/m2). 1 The early detection of inflammation with noninvasive imaging technology may help identify individuals with a high risk of developing NAFLD. Copyright © 2023 AGA Institute. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.cgh.2021.10.033
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1542-3565&title=Clinical+Gastroenterology+%26+Hepatology&atitle=Longitudinal+Changes+in+MR+Elastography-based+Biomarkers+in+Obese+Patients+Treated+with+Bariatric+Surgery.&volume=21&issue=1&spage=220&epage=222.e3&date=2023&doi=10.1016%2Fj.cgh.2021.10.033&pmid=34757198&sid=OVID:medline
+
+<246>
+Unique Identifier
+ 37224410
+Title
+ A Liquid Biopsy-Based Approach to Isolate and Characterize Adipose Tissue-Derived Extracellular Vesicles from Blood.
+Source
+ Acs Nano. 17(11):10252-10268, 2023 06 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mishra S; Kumar A; Kim S; Su Y; Singh S; Sharma M; Almousa S; Rather HA; Jain H; Lee J; Furdui CM; Ahmad S; Ferrario CM; Punzi HA; Chuang CC; Wabitsch M; Kritchevsky SB; Register TC; Deep G
+Author NameID
+ Furdui, Cristina M; ORCID: https://orcid.org/0000-0003-3771-7999
+ Deep, Gagan; ORCID: https://orcid.org/0000-0003-4445-8796
+Authors Full Name
+ Mishra, Shalini; Kumar, Ashish; Kim, Susy; Su, Yixin; Singh, Sangeeta; Sharma, Mitu; Almousa, Sameh; Rather, Hilal A; Jain, Heetanshi; Lee, Jingyun; Furdui, Cristina M; Ahmad, Sarfaraz; Ferrario, Carlos M; Punzi, Henry A; Chuang, Chia-Chi; Wabitsch, Martin; Kritchevsky, Stephen B; Register, Thomas C; Deep, Gagan.
+Institution
+ Mishra, Shalini. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Kumar, Ashish. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Kim, Susy. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Su, Yixin. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Singh, Sangeeta. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Sharma, Mitu. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Almousa, Sameh. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Rather, Hilal A. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Jain, Heetanshi. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Lee, Jingyun. Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27157, United States.
+ Furdui, Cristina M. Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27157, United States.
+ Furdui, Cristina M. Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Ahmad, Sarfaraz. Laboratory of Translational Hypertension, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Ferrario, Carlos M. Laboratory of Translational Hypertension, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Punzi, Henry A. Punzi Medical Center, Punzi Institute of Medicine, Carrollton, Texas 75006, United States.
+ Punzi, Henry A. UT Southwestern Medical Center, Dallas, Texas, 75390, United States.
+ Chuang, Chia-Chi. Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Wabitsch, Martin. Department of Pediatrics and Adolescent Medicine, Center for Rare Endocrine Diseases, Ulm University Medical Centre, Ulm 89069, Germany.
+ Kritchevsky, Stephen B. Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Kritchevsky, Stephen B. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Register, Thomas C. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Register, Thomas C. Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Deep, Gagan. Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+ Deep, Gagan. Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27157, United States.
+ Deep, Gagan. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
+MeSH Subject Headings
+ Adipose Tissue/ch [Chemistry]
+ *Adipose Tissue
+ Liquid Biopsy
+ Extracellular Vesicles/ch [Chemistry]
+ *Extracellular Vesicles
+ Obesity
+ Humans
+ Animals
+ Mice
+ Biomarkers
+Keyword Heading
+ adipose tissue
+ amino acid metabolism
+ extracellular vesicles
+ inflammation
+ liquid biopsies
+ microRNA
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a major risk factor for multiple chronic diseases. Anthropometric and imaging approaches are primarily used to assess adiposity, and there is a dearth of techniques to determine the changes in adipose tissue (AT) at the molecular level. Extracellular vesicles (EVs) have emerged as a novel and less invasive source of biomarkers for various pathologies. Furthermore, the possibility of enriching cell or tissue-specific EVs from the biofluids based on their unique surface markers has led to classifying these vesicles as "liquid biopsies", offering valuable molecular information on hard-to-access tissues. Here, we isolated small EVs from AT (sEVAT) of lean and diet-induced obese (DIO) mice, identified unique surface proteins on sEVAT by surface shaving followed by mass spectrometry, and developed a signature of five unique proteins. Using this signature, we pulled out sEVAT from the blood of mice and validated the specificity of isolated sEVAT by measuring the expression of adiponectin, 38 adipokines on an array, and several adipose tissue-related miRNAs. Furthermore, we provided evidence of sEV applicability in disease prediction by characterizing sEVAT from the blood of lean and DIO mice. Interestingly, sEVAT-DIO cargo showed a stronger pro-inflammatory effect on THP1 monocytes compared to sEVAT-Lean and a significant increase in obesity-associated miRNA expression. Equally important, sEVAT cargo revealed an obesity-associated aberrant amino acid metabolism that was subsequently validated in the corresponding AT. Lastly, we show a significant increase in inflammation-related molecules in sEVAT isolated from the blood of nondiabetic obese (>30 kg/m2) individuals. Overall, the present study offers a less-invasive approach to characterize AT.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1021%2facsnano.3c00422
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mishra&issn=1936-0851&title=Acs+Nano&atitle=A+Liquid+Biopsy-Based+Approach+to+Isolate+and+Characterize+Adipose+Tissue-Derived+Extracellular+Vesicles+from+Blood.&volume=17&issue=11&spage=10252&epage=10268&date=2023&doi=10.1021%2Facsnano.3c00422&pmid=37224410&sid=OVID:medline
+
+<247>
+Unique Identifier
+ 37094629
+Title
+ Diabetes increases mortality in patients with pancreatic and colorectal cancer by promoting cachexia and its associated inflammatory status.
+Source
+ Molecular Metabolism. 73:101729, 2023 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chovsepian A; Prokopchuk O; Petrova G; Gjini T; Kuzi H; Heisz S; Janssen KP; Martignoni ME; Friess H; Hauner H; Rohm M
+Authors Full Name
+ Chovsepian, Alexandra; Prokopchuk, Olga; Petrova, Gabriela; Gjini, Tefta; Kuzi, Hanna; Heisz, Simone; Janssen, Klaus-Peter; Martignoni, Marc E; Friess, Helmut; Hauner, Hans; Rohm, Maria.
+Institution
+ Chovsepian, Alexandra. Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Prokopchuk, Olga. Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; Institute of Experimental Oncology and Therapy Research, School of Medicine, Technical University of Munich, Munich, Germany.
+ Petrova, Gabriela. Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
+ Gjini, Tefta. Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
+ Kuzi, Hanna. Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; Institute of Experimental Oncology and Therapy Research, School of Medicine, Technical University of Munich, Munich, Germany.
+ Heisz, Simone. Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany; Else Kroner Fresenius Center for Nutritional Medicine, ZIEL - Institute for Food and Health, Technical University of Munich, Freising, Germany.
+ Janssen, Klaus-Peter. Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
+ Martignoni, Marc E. Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
+ Friess, Helmut. Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
+ Hauner, Hans. Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany; Else Kroner Fresenius Center for Nutritional Medicine, ZIEL - Institute for Food and Health, Technical University of Munich, Freising, Germany.
+ Rohm, Maria. Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany. Electronic address: maria.rohm@helmholtz-munich.de.
+MeSH Subject Headings
+ Humans
+ Cachexia/me [Metabolism]
+ Retrospective Studies
+ C-Reactive Protein
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Pancreatic Neoplasms/co [Complications]
+ Pancreatic Neoplasms/me [Metabolism]
+ *Pancreatic Neoplasms
+ Body Weight
+ Obesity/co [Complications]
+ Biomarkers
+ Colorectal Neoplasms/co [Complications]
+ *Colorectal Neoplasms
+ Pancreatic Neoplasms
+Keyword Heading
+ Body weight
+ Cancer cachexia
+ Colorectal cancer
+ Inflammation
+ Pancreatic cancer
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Cancer is considered an emerging diabetes complication, with higher incidence and worse prognosis in patients with diabetes. Cancer is frequently associated with cachexia, a systemic metabolic disease causing wasting. It is currently unclear how diabetes affects the development and progression of cachexia.
+
+ METHODS: We investigated the interplay between diabetes and cancer cachexia retrospectively in a cohort of 345 patients with colorectal and pancreatic cancer. We recorded body weight, fat mass, muscle mass, clinical serum values, and survival of these patients. Patients were grouped either into diabetic/non-diabetic groups based on previous diagnosis, or into obese/non-obese groups based on body mass index (BMI >=30 kg/m2 was considered obese).
+
+ RESULTS: The pre-existence of type 2 diabetes, but not obesity, in patients with cancer led to increased cachexia incidence (80%, compared to 61% without diabetes, p <= 0.05), higher weight loss (8.9% vs. 6.0%, p <= 0.001), and reduced survival probability (median survival days: 689 vs. 538, Chi square = 4.96, p <= 0.05) irrespective of the initial body weight or tumor progression. Patients with diabetes and cancer showed higher serum levels of C-reactive protein (0.919 mug/mL vs. 0.551 mug/mL, p <= 0.01) and interleukin 6 (5.98 pg/mL vs. 3.75 pg/mL, p <= 0.05) as well as lower serum albumin levels (3.98 g/dL vs. 4.18 g/dL, p <= 0.05) than patients with cancer without diabetes. In a sub-analysis of patients with pancreatic cancer, pre-existing diabetes worsened weight loss (9.95% vs. 6.93%, p <= 0.01), and increased the duration of hospitalization (24.41 days vs. 15.85 days, p <= 0.001). Further, diabetes aggravated clinical manifestations of cachexia, as changes in the aforementioned biomarkers were more pronounced in patients with diabetes and cachexia co-existence, compared to cachectic patients without diabetes (C-reactive protein: 2.300 mug/mL vs. 0.571 mug/mL, p <= 0.0001; hemoglobin: 11.24 g/dL vs. 12.52 g/dL, p <= 0.05).
+
+ CONCLUSIONS: We show for the first time that pre-existing diabetes aggravates cachexia development in patients with colorectal and pancreatic cancer. This is important when considering cachexia biomarkers and weight management in patients with co-existing diabetes and cancer. Copyright © 2023 The Author(s). Published by Elsevier GmbH.. All rights reserved.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.molmet.2023.101729
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chovsepian&issn=2212-8778&title=Molecular+Metabolism&atitle=Diabetes+increases+mortality+in+patients+with+pancreatic+and+colorectal+cancer+by+promoting+cachexia+and+its+associated+inflammatory+status.&volume=73&issue=&spage=101729&epage=&date=2023&doi=10.1016%2Fj.molmet.2023.101729&pmid=37094629&sid=OVID:medline
+
+<248>
+Unique Identifier
+ 37226407
+Title
+ The role of bioimpedance analysis in overweight and obese patients with acute heart failure: a pilot study.
+Source
+ ESC heart failure. 10(4):2418-2426, 2023 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Venegas-Rodriguez A; Pello AM; Lopez-Castillo M; Taibo Urquia M; Balaguer-German J; Munte A; Gonzalez-Martin G; Carriazo-Julio SM; Martinez-Milla J; Kallmeyer A; Gonzalez Lorenzo O; Gaebelt Slocker HP; Tunon J; Gonzalez-Parra E; Acena A
+Author NameID
+ Venegas-Rodriguez, Ana; ORCID: https://orcid.org/0000-0003-0603-0094
+Authors Full Name
+ Venegas-Rodriguez, Ana; Pello, Ana Maria; Lopez-Castillo, Marta; Taibo Urquia, Mikel; Balaguer-German, Jorge; Munte, Alicia; Gonzalez-Martin, Guillermo; Carriazo-Julio, Sol Maria; Martinez-Milla, Juan; Kallmeyer, Andrea; Gonzalez Lorenzo, Oscar; Gaebelt Slocker, Hans Paul; Tunon, Jose; Gonzalez-Parra, Emilio; Acena, Alvaro.
+Institution
+ Venegas-Rodriguez, Ana. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Pello, Ana Maria. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Lopez-Castillo, Marta. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Taibo Urquia, Mikel. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Balaguer-German, Jorge. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Munte, Alicia. Universidad Autonoma de Madrid, Ciudad Universitaria de Cantoblanco, Madrid, 28049, Spain.
+ Gonzalez-Martin, Guillermo. Department of Nephrology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Carriazo-Julio, Sol Maria. Department of Nephrology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Martinez-Milla, Juan. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Martinez-Milla, Juan. Centro Nacional de Investigaciones Cardiovasculares (CNIC), C. de Melchor Fernandez Almagro, 3, Madrid, 28029, Spain.
+ Kallmeyer, Andrea. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Gonzalez Lorenzo, Oscar. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Gaebelt Slocker, Hans Paul. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Tunon, Jose. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Tunon, Jose. Universidad Autonoma de Madrid, Ciudad Universitaria de Cantoblanco, Madrid, 28049, Spain.
+ Gonzalez-Parra, Emilio. Universidad Autonoma de Madrid, Ciudad Universitaria de Cantoblanco, Madrid, 28049, Spain.
+ Gonzalez-Parra, Emilio. Department of Nephrology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Acena, Alvaro. Department of Cardiology, IIS-Fundacion Jimenez Diaz, Avda. Reyes Catolicos, 2, Madrid, 28040, Spain.
+ Acena, Alvaro. Universidad Autonoma de Madrid, Ciudad Universitaria de Cantoblanco, Madrid, 28049, Spain.
+MeSH Subject Headings
+ Humans
+ Overweight/co [Complications]
+ Overweight/ep [Epidemiology]
+ *Overweight
+ Pilot Projects
+ Single-Blind Method
+ Biomarkers
+ Natriuretic Peptide, Brain
+ Obesity/co [Complications]
+ Heart Failure/co [Complications]
+ Heart Failure/ep [Epidemiology]
+ Heart Failure/di [Diagnosis]
+ *Heart Failure
+Keyword Heading
+ Acute kidney injury
+ Bioimpedance analysis
+ Heart failure
+ Natriuretic peptides
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Residual congestion at the time of hospital discharge is an important readmission risk factor, and its detection with physical examination and usual diagnostic techniques have strong limitations in overweight and obese patients. New tools like bioelectrical impedance analysis (BIA) could help to determine when euvolaemia is reached. The aim of this study was to investigate the usefulness of BIA in management of heart failure (HF) in overweight and obese patients.
+
+ METHODS AND RESULTS: Our study is a single-centre, single-blind, randomized controlled trial that included 48 overweight and obese patients admitted for acute HF. The study population was randomized into two arms: BIA-guided group and standard care. Serum electrolytes, kidney function, and natriuretic peptides were followed up during their hospital stay and at 90 days after discharge. The primary endpoint was development of severe acute kidney injury (AKI) defined as an increase in serum creatinine by >0.5 mg/dL during hospitalization, and the main secondary endpoint was the reduction of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels during hospitalization and within 90 days after discharge. The BIA-guided group showed a remarkable lower incidence of severe AKI, although no significant differences were found (41.4% vs. 16.7%; P = 0.057). The proportion of patients who achieved levels of NT-proBNP < 1000 pg/mL at 90 days was significantly higher in the BIA-guided group than in the standard group (58.8% vs. 25%; P = 0.049). No differences were observed in the incidence of adverse outcomes at 90 days.
+
+ CONCLUSIONS: Among overweight and obese patients with HF, BIA reduces NT-proBNP levels at 90 days compared with standard care. In addition, there is a trend towards lower incidence of AKI in the BIA-guided group. Although more studies are required, BIA could be a useful tool in decompensated HF management in overweight and obese patients. Copyright © 2023 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2fehf2.14398
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Venegas-Rodriguez&issn=2055-5822&title=ESC+heart+failure&atitle=The+role+of+bioimpedance+analysis+in+overweight+and+obese+patients+with+acute+heart+failure%3A+a+pilot+study.&volume=10&issue=4&spage=2418&epage=2426&date=2023&doi=10.1002%2Fehf2.14398&pmid=37226407&sid=OVID:medline
+
+<249>
+Unique Identifier
+ 37224923
+Title
+ NIS2+ TM, an optimisation of the blood-based biomarker NIS4 R technology for the detection of at-risk NASH: A prospective derivation and validation study.
+Source
+ Journal of Hepatology. 79(3):758-767, 2023 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Harrison SA; Ratziu V; Magnanensi J; Hajji Y; Deledicque S; Majd Z; Rosenquist C; Hum DW; Staels B; Anstee QM; Sanyal AJ
+Authors Full Name
+ Harrison, Stephen A; Ratziu, Vlad; Magnanensi, Jeremy; Hajji, Yacine; Deledicque, Sylvie; Majd, Zouher; Rosenquist, Christian; Hum, Dean W; Staels, Bart; Anstee, Quentin M; Sanyal, Arun J.
+Institution
+ Harrison, Stephen A. Summit Clinical Research, San Antonio, TX, USA; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
+ Ratziu, Vlad. Sorbonne Universite, Institute for Cardiometabolism and Nutrition, Hopital Pitie-Salpetriere, Paris, France.
+ Magnanensi, Jeremy. Genfit S.A., Loos, France. Electronic address: jeremy.magnanensi@genfit.com.
+ Hajji, Yacine. Genfit S.A., Loos, France.
+ Deledicque, Sylvie. Genfit S.A., Loos, France.
+ Majd, Zouher. Genfit S.A., Loos, France.
+ Rosenquist, Christian. Genfit S.A., Loos, France.
+ Hum, Dean W. Genfit S.A., Loos, France.
+ Staels, Bart. Universite de Lille, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France.
+ Anstee, Quentin M. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK; Newcastle NIHR Biomedical Research Centre, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle Upon Tyne, UK.
+ Sanyal, Arun J. Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
+MeSH Subject Headings
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ *Non-alcoholic Fatty Liver Disease
+ Humans
+ *Diagnostic Tests, Routine
+ Reproducibility of Results
+ Obesity/co [Complications]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Biomarkers
+ MicroRNAs
+Keyword Heading
+ Diagnostic test
+ Fibrosis
+ NAFLD
+ NASH
+ NIS2+ TM
+ NIS4 R
+ Non-alcoholic fatty liver disease
+ Non-alcoholic steatohepatitis
+ Obesity
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: NIS4 R is a blood-based non-invasive test designed to effectively rule in/rule out at-risk non-alcoholic steatohepatitis (NASH), defined as non-alcoholic fatty liver disease activity score >=4 and significant fibrosis (stage >=2), among patients with metabolic risk factors. Robustness of non-invasive test scores across characteristics of interest including age, type 2 diabetes mellitus, and sex, and optimised analytical aspects are critical for large-scale implementation in clinical practice. We developed and validated NIS2+ TM, an optimisation of NIS4 R, specifically designed to improve score robustness.
+
+ METHODS: A well-balanced training cohort (n = 198) included patients from the GOLDEN-505 trial. The validation (n = 684) and test (n = 2,035) cohorts included patients from the RESOLVE-IT trial. Well-matched subgroups were created to avoid potential confounding effects during modelling and analysis of score robustness. Models were trained using logistic regressions for at-risk NASH detection and compared using Bayesian information criteria. Performance of NIS2+ TM was compared with that of NIS4 R, Fibrosis-4, and alanine aminotransferase using area under the receiver operating characteristic curve, and robustness was analysed through score distribution.
+
+ RESULTS: Using the training cohort to compare all combinations of NIS4 R biomarkers, NIS2 (miR-34a-5p, YKL-40) was identified as the best combination of parameters. To correct for the sex effect on miR-34a-5p (validation cohort), sex and sex * miR-34a-5p parameters were added, creating NIS2+ TM. In the test cohort, NIS2+ TM exhibited a statistically higher area under the receiver operating characteristic curve (0.813) vs. NIS4 R (0.792; p = 0.0002), Fibrosis-4 (0.653; p <0.0001), and alanine aminotransferase (0.699; p <0.0001). NIS2+ TM scores were not affected by age, sex, BMI, or type 2 diabetes mellitus status, providing robust clinical performances irrespective of patient characteristics.
+
+ CONCLUSION: NIS2+ TM constitutes a robust optimisation of NIS4 R technology for the detection of at-risk NASH.
+
+ IMPACT AND IMPLICATIONS: The development of non-invasive tests for accurate, large-scale detection of patients with at-risk non-alcoholic steatohepatitis (NASH; defined as NASH with non-alcoholic fatty liver disease activity score >=4 and fibrosis stage >=2) - who are at higher risk for disease progression and for developing liver-related life-threatening outcomes - is critical for identifying this patient population in the clinical setting and improving the screening process of NASH clinical trials. We report the development and validation of NIS2+ TM, a diagnostic test designed as an optimisation of NIS4 R technology, a blood-based panel currently used to detect at-risk NASH in patients with metabolic risk factors. NIS2+ TM showed improved performance for the detection of at-risk NASH compared with NIS4 R and other non-invasive liver tests that was not impacted by patients' characteristics of interest, such as age, sex, type 2 diabetes mellitus, BMI, dyslipidaemia, and hypertension. This makes NIS2+ TM a robust and reliable tool for the diagnosis of at-risk NASH among patients with metabolic risk factors, and an effective candidate for large-scale implementation in clinical practice and clinical trials. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.jhep.2023.04.031
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Harrison&issn=0168-8278&title=Journal+of+Hepatology&atitle=NIS2%2B+TM%2C+an+optimisation+of+the+blood-based+biomarker+NIS4+R+technology+for+the+detection+of+at-risk+NASH%3A+A+prospective+derivation+and+validation+study.&volume=79&issue=3&spage=758&epage=767&date=2023&doi=10.1016%2Fj.jhep.2023.04.031&pmid=37224923&sid=OVID:medline
+
+<250>
+Unique Identifier
+ 37224046
+Title
+ The Importance of Serum Homocysteine as a Biomarker in Diabetic and Obese COVID-19 Patients.
+Source
+ Cellular & Molecular Biology. 69(2):52-59, 2023 Feb 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shawkat Ahmed H; Noori SH
+Authors Full Name
+ Shawkat Ahmed, Haitham; Noori, Saman Hussein.
+Institution
+ Shawkat Ahmed, Haitham. B.Sc Biotechnology, College of Sciences, Baghdad University, Iraq. haithim.shawket@yahoo.com.
+ Noori, Saman Hussein. Department of Biochemistry, College of Medicine, University of Sulaimani, Kurdistan Region-Iraq. haithim.shawket@yahoo.com.
+MeSH Subject Headings
+ Female
+ Male
+ Humans
+ Interleukin-6
+ *COVID-19
+ Obesity/co [Complications]
+ Biomarkers
+ Folic Acid
+ Homocysteine
+ Vitamin B 12
+ *Diabetes Mellitus
+Abstract
+ Homocysteine is a possible risk marker in hematological complications of COVID-19 infection. This study aimed to elucidate the significance of homocysteine as a biomarker for COVID-19 infection, and the relation of homocysteine with COVID-19 severity in obese people and diabetic patients. The study groups were 1- COVID-19 patients + Diabetic + Obese (CDO), 2- COVID-19 patients + Diabetic (CD), 3- COVID-19 patients + Obese (CO), 4- Healthy Group (HG). Serum levels of homocysteine, IL-6, D-dimer, vitamin B12, and folate were measured by a fully automated biochemistry device Cobas 6000 analyzer series. The mean serum concentration of homocysteine in the COD, CD, CO and H groups were 32.0114, 23.604, 19.4154, and 9.3206 umol/l respectively. The mean concentration of homocysteine levels between every two groups was statistically significant differences (P<0.05) except for the CD and the CO group (P=0.957). In the CDO group, the males have higher mean concentrations than females (P<0.05). The means of homocysteine concentrations in the CDO group among different age groups were different (P <0.001). The serum homocysteine level in the CDO group has a strong positive correlation (R=0.748) with D-dimer and a strong negative correlation (R= - 0.788) with serum folate, while its correlation with serum vitamin B12 is moderate negative (-0.499) and its correlation with serum IL-6 is weakly positive (R=0.376). The AUC value for homocysteine in predicting COVID-19 in the CDO group was 0.843, while 0.714 for the CD group, and 0.728 for the CO group. The serum homocysteine concentration test for all study groups was compared to the serum IL-6 test and the sensitivity was equal to 95% and its specificity was 67.5%. Serum homocysteine has potential predictive power in COVID-19 patients, and the severity of COVID-19 infection and the type of comorbidity is associated with higher sensitivity and specificity of homocysteine serological tests.
+Registry Number/Name of Substance
+ 0 (Interleukin-6). 0 (Biomarkers). 935E97BOY8 (Folic Acid). 0LVT1QZ0BA (Homocysteine). P6YC3EG204 (Vitamin B 12).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.14715%2fcmb%2f2023.69.2.9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shawkat+Ahmed&issn=0145-5680&title=Cellular+%26+Molecular+Biology&atitle=The+Importance+of+Serum+Homocysteine+as+a+Biomarker+in+Diabetic+and+Obese+COVID-19+Patients.&volume=69&issue=2&spage=52&epage=59&date=2023&doi=10.14715%2Fcmb%2F2023.69.2.9&pmid=37224046&sid=OVID:medline
+
+<251>
+Unique Identifier
+ 37219593
+Title
+ The association of obesity-related dietary patterns and main food groups derived by reduced-rank regression with cardiovascular diseases incidence and all-cause mortality: findings from 116,711 adults.
+Source
+ European Journal of Nutrition. 62(6):2605-2619, 2023 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Maimaitiyiming M; Yang H; Li H; Xu C; Li S; Zhou L; Zhang X; Wang Y
+Authors Full Name
+ Maimaitiyiming, Maiwulamujiang; Yang, Hongxi; Li, Huiping; Xu, Chenjie; Li, Shu; Zhou, Lihui; Zhang, Xinyu; Wang, Yaogang.
+Institution
+ Maimaitiyiming, Maiwulamujiang. School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping District, Tianjin, 300070, China.
+ Yang, Hongxi. Department of Bioinformatics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
+ Li, Huiping. School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping District, Tianjin, 300070, China.
+ Xu, Chenjie. School of Public Health, Hangzhou Normal University, Hangzhou, China.
+ Li, Shu. School of Management, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
+ Zhou, Lihui. School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping District, Tianjin, 300070, China.
+ Zhang, Xinyu. School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping District, Tianjin, 300070, China.
+ Wang, Yaogang. School of Public Health, Tianjin Medical University, Qixiangtai Road 22, Heping District, Tianjin, 300070, China. YaogangWANG@tmu.edu.cn.
+MeSH Subject Headings
+ Humans
+ Adult
+ *Cardiovascular Diseases
+ Incidence
+ Cross-Sectional Studies
+ Diet/ae [Adverse Effects]
+ Obesity/ep [Epidemiology]
+ Obesity/co [Complications]
+ Biomarkers
+ Risk Factors
+Keyword Heading
+ Cardiovascular diseases
+ Dietary pattern
+ Obesity
+ Reduced rank regression
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Research about using reduced-rank regression (RRR) to simultaneously study the effects of both individual and combined consumption of foods on cardiovascular diseases (CVD) is scarce.
+
+ METHODS: This study included 116,711 CVD-free participants (a median of 11.8 year follow-up) with 2 or more 24-h online dietary assessments. A total of 210 food items were classified into 45 food groups, and the mean amount of each food group was used in RRR to derive dietary patterns (DPs) explaining the maximum shared variation in obesity-related indicators. The associations of DPs and its main food groups (
+
+ factor loading
+
+ [Formula: see text] 0.2) with the incident CVD and all-cause mortality were examined by Cox model. In cross-sectional analyses, the associations of DP scores with cardiometabolic risk factors (biomarkers) were examined by linear regression.
+
+ RESULTS: The derived DP was characterized by higher intakes of beer and cider, high-sugar beverages, processed meat, red meat, artificial sweetener, and crisps, chips and savory snacks, and lower intakes of olive oil, high fiber breakfast cereals, tea, and vegetable. Compared to the lowest dietary score quintile, those in the highest were associated with higher risks of total CVD (adjusted-HR: 1.45, 95% CI 1.33-1.57) and all-cause mortality (adjusted-HR 1.31, 95% CI 1.18-1.45). We observed consumption alone of these food groups had a consistent but limited health effect on total CVD and all-cause death incidence. These associations were modified by age and sex. Higher DP scores were related to adverse biomarkers profiles.
+
+ CONCLUSIONS: We developed obesity-related DPs prospectively associated with increased risks of CVD and all-cause mortality. Copyright © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs00394-023-03177-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Maimaitiyiming&issn=1436-6207&title=European+Journal+of+Nutrition&atitle=The+association+of+obesity-related+dietary+patterns+and+main+food+groups+derived+by+reduced-rank+regression+with+cardiovascular+diseases+incidence+and+all-cause+mortality%3A+findings+from+116%2C711+adults.&volume=62&issue=6&spage=2605&epage=2619&date=2023&doi=10.1007%2Fs00394-023-03177-x&pmid=37219593&sid=OVID:medline
+
+<252>
+Unique Identifier
+ 37218594
+Title
+ Branched-Chain Amino Acids in Computed Tomography-Defined Adipose Depots and Coronary Artery Disease: A PROMISE Trial Biomarker Substudy.
+Source
+ Journal of the American Heart Association. 12(11):e028410, 2023 06 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhao E; Giamberardino SN; Pagidipati NJ; Voora D; Ginsburg GS; Hoffmann U; Karady J; Ferencik M; Douglas PS; Foldyna B; Shah SH
+Author NameID
+ Zhao, Elizabeth; ORCID: https://orcid.org/0000-0002-8350-2043
+ Giamberardino, Stephanie N; ORCID: https://orcid.org/0000-0001-7440-5156
+ Pagidipati, Neha J; ORCID: https://orcid.org/0000-0002-5004-8868
+ Voora, Deepak; ORCID: https://orcid.org/0000-0003-0015-5179
+ Ginsburg, Geoffrey S; ORCID: https://orcid.org/0000-0003-4739-9808
+ Hoffmann, Udo; ORCID: https://orcid.org/0000-0001-5514-769X
+ Karady, Julia; ORCID: https://orcid.org/0000-0002-6640-6260
+ Ferencik, Maros; ORCID: https://orcid.org/0000-0001-5872-2223
+ Douglas, Pamela S; ORCID: https://orcid.org/0000-0001-9876-4049
+ Foldyna, Borek; ORCID: https://orcid.org/0000-0002-2466-4827
+ Shah, Svati H; ORCID: https://orcid.org/0000-0002-3495-2830
+Authors Full Name
+ Zhao, Elizabeth; Giamberardino, Stephanie N; Pagidipati, Neha J; Voora, Deepak; Ginsburg, Geoffrey S; Hoffmann, Udo; Karady, Julia; Ferencik, Maros; Douglas, Pamela S; Foldyna, Borek; Shah, Svati H.
+Institution
+ Zhao, Elizabeth. Duke University School of Medicine Durham NC.
+ Giamberardino, Stephanie N. Duke Molecular Physiology Institute Duke University School of Medicine Durham NC.
+ Pagidipati, Neha J. Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC.
+ Pagidipati, Neha J. Duke Clinical Research Institute Durham NC.
+ Voora, Deepak. Cardiovascular Imaging Research Center Massachusetts General Hospital-Harvard Medical School Boston MA.
+ Ginsburg, Geoffrey S. Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC.
+ Hoffmann, Udo. Cardiovascular Imaging Research Center Massachusetts General Hospital-Harvard Medical School Boston MA.
+ Karady, Julia. Cardiovascular Imaging Research Center Massachusetts General Hospital-Harvard Medical School Boston MA.
+ Ferencik, Maros. Knight Cardiovascular Institute Oregon Health and Science University Portland OR.
+ Douglas, Pamela S. Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC.
+ Foldyna, Borek. Cardiovascular Imaging Research Center Massachusetts General Hospital-Harvard Medical School Boston MA.
+ Shah, Svati H. Duke Molecular Physiology Institute Duke University School of Medicine Durham NC.
+ Shah, Svati H. Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC.
+ Shah, Svati H. Duke Clinical Research Institute Durham NC.
+MeSH Subject Headings
+ Humans
+ Middle Aged
+ Coronary Artery Disease/et [Etiology]
+ *Coronary Artery Disease
+ Adiposity
+ Amino Acids, Branched-Chain/me [Metabolism]
+ Prospective Studies
+ Risk Factors
+ Biomarkers/me [Metabolism]
+ Tomography, X-Ray Computed
+ Obesity/co [Complications]
+ Chest Pain
+ Coronary Angiography/mt [Methods]
+ Adipose Tissue/dg [Diagnostic Imaging]
+ Adipose Tissue/me [Metabolism]
+Keyword Heading
+ Mendelian randomization analysis
+ branched-chain amino acids
+ coronary artery disease
+ coronary computed tomography angiography
+ epicardial adipose tissue
+ hepatic steatosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background The interplay between branched-chain amino acid (BCAA) metabolism, an important pathway in adiposity and cardiometabolic disease, and visceral adipose depots such as hepatic steatosis (HS) and epicardial adipose tissue is unknown. We leveraged the PROMISE clinical trial with centrally adjudicated coronary computed tomography angiography imaging to determine relationships between adipose depots, BCAA dysregulation, and coronary artery disease (CAD). Methods and Results The PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) trial randomized 10 003 outpatients with stable chest pain to computed tomography angiography versus standard-of-care diagnostics. For this study, we included 1798 participants with available computed tomography angiography data and biospecimens. Linear and logistic regression were used to determine associations between a molar sum of BCAAs measured by nuclear magnetic resonance spectroscopy with body mass index, adipose traits, and obstructive CAD. Mendelian randomization was then used to determine if BCAAs are in the causal pathway for adipose depots or CAD. The study sample had a mean age of 60 years (SD, 8.0), body mass index of 30.6 (SD, 5.9), and epicardial adipose tissue volume of 57.3 (SD, 21.3) cm3/m2; 27% had HS, and 14% had obstructive CAD. BCAAs were associated with body mass index (multivariable beta 0.12 per SD increase in BCAA [95% CI, 0.08-0.17]; P=4x10-8). BCAAs were also associated with HS (multivariable odds ratio [OR], 1.46 per SD increase in BCAAs [95% CI, 1.28-1.67]; P=2x10-8), but BCAAs were associated only with epicardial adipose tissue volume (odds ratio, 1.18 [95% CI, 1.07-1.32]; P=0.002) and obstructive CAD (OR, 1.18 [95% CI, 1.04-1.34]; P=0.009) in univariable models. Two-sample Mendelian randomization did not support the role of BCAAs as within the causal pathways for HS or CAD. Conclusions BCAAs have been implicated in the pathogenesis of cardiometabolic diseases, and adipose depots have been associated with the risk of CAD. Leveraging a large clinical trial, we further establish the role of dysregulated BCAA catabolism in HS and CAD, although BCAAs did not appear to be in the causal pathway of either disease. This suggests that BCAAs may serve as an independent circulating biomarker of HS and CAD but that their association with these cardiometabolic diseases is mediated through other pathways.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers).
+Publication Type
+ Multicenter Study. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1161%2fJAHA.122.028410
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhao&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Branched-Chain+Amino+Acids+in+Computed+Tomography-Defined+Adipose+Depots+and+Coronary+Artery+Disease%3A+A+PROMISE+Trial+Biomarker+Substudy.&volume=12&issue=11&spage=e028410&epage=&date=2023&doi=10.1161%2FJAHA.122.028410&pmid=37218594&sid=OVID:medline
+
+<253>
+Unique Identifier
+ 37207947
+Title
+ Consumption of ultra-processed foods is associated with depression, mesocorticolimbic volume, and inflammation.
+Source
+ Journal of Affective Disorders. 335:340-348, 2023 08 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Contreras-Rodriguez O; Reales-Moreno M; Fernandez-Barres S; Cimpean A; Arnoriaga-Rodriguez M; Puig J; Biarnes C; Motger-Alberti A; Cano M; Fernandez-Real JM
+Authors Full Name
+ Contreras-Rodriguez, Oren; Reales-Moreno, Marta; Fernandez-Barres, Silvia; Cimpean, Anna; Arnoriaga-Rodriguez, Maria; Puig, Josep; Biarnes, Carles; Motger-Alberti, Anna; Cano, Marta; Fernandez-Real, Jose Manuel.
+Institution
+ Contreras-Rodriguez, Oren. Department of Radiology-Medical Imaging (IDI), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain; Department of Psychiatry and Legal Medicine, Faculty of Medicine, Universitat Autonoma de Barcelona, Bellaterra, Spain; Health Institute Carlos III (ISCIII) and CIBERSAM, Madrid, Spain. Electronic address: ocontreras@idibgi.org.
+ Reales-Moreno, Marta. Department of Radiology-Medical Imaging (IDI), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain; Department of Medical Sciences, School of Medicine, University of Girona, Spain.
+ Fernandez-Barres, Silvia. Agencia de Salut Publica de Barcelona, Pl. Lesseps 1, 08023 Barcelona, Spain.
+ Cimpean, Anna. Department of Radiology-Medical Imaging (IDI), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain.
+ Arnoriaga-Rodriguez, Maria. Department of Medical Sciences, School of Medicine, University of Girona, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Girona, Spain.
+ Puig, Josep. Department of Radiology-Medical Imaging (IDI), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain; Department of Medical Sciences, School of Medicine, University of Girona, Spain; Institute of Diagnostic Imaging (IDI)-Research Unit (IDIR), Parc Sanitari Pere Virgili, Barcelona, Spain.
+ Biarnes, Carles. Department of Radiology-Medical Imaging (IDI), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain.
+ Motger-Alberti, Anna. Department of Medical Sciences, School of Medicine, University of Girona, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Girona, Spain.
+ Cano, Marta. Health Institute Carlos III (ISCIII) and CIBERSAM, Madrid, Spain; Sant Pau Mental Health Research Group, Institut d'Investigacio Biomedica Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Psychobiology and Methodology of Health Sciences, Universitat Autonoma de Barcelona, Barcelona, Spain.
+ Fernandez-Real, Jose Manuel. Department of Medical Sciences, School of Medicine, University of Girona, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Girona, Spain. Electronic address: jmfreal@idibgi.org.
+MeSH Subject Headings
+ Adult
+ Humans
+ *Food, Processed
+ *Depression
+ Fast Foods
+ Diet
+ Obesity/et [Etiology]
+ Inflammation/dg [Diagnostic Imaging]
+ Inflammation/co [Complications]
+ Biomarkers
+Keyword Heading
+ Amygdala
+ Cingulate cortex
+ Depressive symptoms
+ Inflammation
+ Obesity
+ Ultra-processed foods and drinks
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The consumption of ultra-processed foods and drinks (UPF) has been associated with depression and inflammation and preclinical studies showed that some UPF components disrupt the amygdala-hippocampal complex. We combine diet, clinical and brain imaging data to investigate the relationship between the UPF consumption, depressive symptoms, and brain volumes in humans, considering interactions with obesity, and the mediation effect of inflammation biomarkers.
+
+ METHODS: One-hundred fifty-two adults underwent diet, depressive symptoms, anatomic magnetic resonance imaging assessments and laboratory tests. Relationships between the % of UPF consumption (in grams) of the total diet, depressive symptoms, and gray matter brain volumes were explored using several adjusted regression models, and in interaction with the presence of obesity. Whether inflammatory biomarkers (i.e., white blood cell count, lipopolysaccharide-binding protein, c-reactive protein) mediate the previous associations was investigated using R mediation package.
+
+ RESULTS: High UPF consumption was associated with higher depressive symptoms in all participants (beta = 0.178, CI = 0.008-0.261) and in those with obesity (beta = 0.214, CI = -0.004-0.333). Higher consumption was also associated with lower volumes in the posterior cingulate cortex and the left amygdala, which in the participants with obesity also encompassed the left ventral putamen and the dorsal frontal cortex. White blood count levels mediated the association between UPF consumption and depressive symptoms (p = 0.022).
+
+ LIMITATIONS: The present study precludes any causal conclusions.
+
+ CONCLUSIONS: UPF consumption is associated with depressive symptoms and lower volumes within the mesocorticolimbic brain network implicated in reward processes and conflict monitoring. Associations were partially dependent on obesity and white blood cell count. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.jad.2023.05.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Contreras-Rodriguez&issn=0165-0327&title=Journal+of+Affective+Disorders&atitle=Consumption+of+ultra-processed+foods+is+associated+with+depression%2C+mesocorticolimbic+volume%2C+and+inflammation.&volume=335&issue=&spage=340&epage=348&date=2023&doi=10.1016%2Fj.jad.2023.05.009&pmid=37207947&sid=OVID:medline
+
+<254>
+Unique Identifier
+ 37203224
+Title
+ Metabolic effects of early life stress and pre-pregnancy obesity are long lasting and sex specific in mice.
+Source
+ European Journal of Neuroscience. 58(1):2215-2231, 2023 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Brix LM; Monleon D; Collado MC; Ederveen THA; Toksoz I; Bordes J; van Doeselaar L; Engelhardt C; Mitra S; Narayan S; Schmidt MV
+Authors Full Name
+ Brix, Lea M; Monleon, Daniel; Collado, Maria Carmen; Ederveen, Thomas H A; Toksoz, Irmak; Bordes, Joeri; van Doeselaar, Lotte; Engelhardt, Clara; Mitra, Shiladitya; Narayan, Sowmya; Schmidt, Mathias V.
+Institution
+ Brix, Lea M. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
+ Brix, Lea M. International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
+ Monleon, Daniel. Department of Pathology, Medicine and Odontology Faculty, University of Valencia, Valencia, Spain.
+ Monleon, Daniel. Health Research Institute INCLIVA/CIBERFES, Valencia, Spain.
+ Collado, Maria Carmen. Institute of Agrochemistry and Food Technology-National ResearchCouncil (IATA-CSIC), Valencia, Spain.
+ Ederveen, Thomas H A. Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), Nijmegen, The Netherlands.
+ Toksoz, Irmak. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
+ Bordes, Joeri. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
+ van Doeselaar, Lotte. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
+ van Doeselaar, Lotte. International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
+ Engelhardt, Clara. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
+ Mitra, Shiladitya. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
+ Narayan, Sowmya. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
+ Narayan, Sowmya. International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
+ Schmidt, Mathias V. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
+MeSH Subject Headings
+ Animals
+ Mice
+ Female
+ Male
+ Humans
+ Pregnancy
+ *Obesity, Maternal
+ *Adverse Childhood Experiences
+ Obesity/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Rodentia
+ Biomarkers
+ Prenatal Exposure Delayed Effects/me [Metabolism]
+ *Prenatal Exposure Delayed Effects
+Keyword Heading
+ body weight
+ early life stress
+ maternal obesity
+ metabolome
+ microbiota
+ sex-specific
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Early life stress (ELS) is associated with metabolic, cognitive, and psychiatric diseases and has a very high prevalence, highlighting the urgent need for a better understanding of the versatile physiological changes and identification of predictive biomarkers. In addition to programming the hypothalamic-pituitary-adrenal (HPA) axis, ELS may also affect the gut microbiota and metabolome, opening up a promising research direction for identifying early biomarkers of ELS-induced (mal)adaptation. Other factors affecting these parameters include maternal metabolic status and diet, with maternal obesity shown to predispose offspring to later metabolic disease. The aim of the present study was to investigate the long-term effects of ELS and maternal obesity on the metabolic and stress phenotype of rodent offspring. To this end, offspring of both sexes were subjected to an adverse early-life experience, and their metabolic and stress phenotypes were examined. In addition, we assessed whether a prenatal maternal and an adult high-fat diet (HFD) stressor further shape observed ELS-induced phenotypes. We show that ELS has long-term effects on male body weight (BW) across the lifespan, whereas females more successfully counteract ELS-induced weight loss, possibly by adapting their microbiota, thereby stabilizing a balanced metabolome. Furthermore, the metabolic effects of a maternal HFD on BW are exclusively triggered by a dietary challenge in adult offspring and are more pronounced in males than in females. Overall, our study suggests that the female microbiota protects against an ELS challenge, rendering them more resilient to additional maternal- and adult nutritional stressors than males. Copyright © 2023 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1111%2fejn.16047
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Brix&issn=0953-816X&title=European+Journal+of+Neuroscience&atitle=Metabolic+effects+of+early+life+stress+and+pre-pregnancy+obesity+are+long+lasting+and+sex+specific+in+mice.&volume=58&issue=1&spage=2215&epage=2231&date=2023&doi=10.1111%2Fejn.16047&pmid=37203224&sid=OVID:medline
+
+<255>
+Unique Identifier
+ 37202751
+Title
+ Association between the insulin resistance marker TyG index and subsequent adverse long-term cardiovascular events in young and middle-aged US adults based on obesity status.
+Source
+ Lipids in Health & Disease. 22(1):65, 2023 May 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen W; Ding S; Tu J; Xiao G; Chen K; Zhang Y; Huang R; Liao Y
+Authors Full Name
+ Chen, Weihua; Ding, Shan; Tu, Jiabin; Xiao, Guitao; Chen, Kaihong; Zhang, Yanbin; Huang, Rongchong; Liao, Ying.
+Institution
+ Chen, Weihua. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
+ Ding, Shan. Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, China.
+ Tu, Jiabin. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
+ Xiao, Guitao. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
+ Chen, Kaihong. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
+ Zhang, Yanbin. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
+ Huang, Rongchong. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100053, China. rchuang@ccmu.edu.cn.
+ Liao, Ying. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. wingjays@163.com.
+MeSH Subject Headings
+ Middle Aged
+ Adult
+ Humans
+ Insulin
+ *Insulin Resistance
+ Nutrition Surveys
+ Retrospective Studies
+ Glucose
+ Obesity
+ Triglycerides
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Blood Glucose
+ Biomarkers
+ Risk Factors
+ Risk Assessment
+Keyword Heading
+ All-cause mortality
+ Cardiovascular events
+ NHANES
+ Obesity
+ Triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: A lthough the triglyceride-glucose (TyG) index has been shown to closely correlate with cardiometabolic outcomes and predict cardiovascular events in many groups, it remains unclear whether obese status in young and middle-aged adults is associated with long-term unfavorable cardiovascular events. This warrants further investigation.
+
+ METHODS: This retrospective cohort study analyzed data from the National Health and Nutrition Examination Survey spanning the years 1999-2018, with follow-up for mortality status until December 31, 2019. To categorize participants based on the TyG level, the optimal critical value was determined through restricted cubic spline function analysis, dividing them into high and low TyG groups. The study assessed the relationship between TyG and cardiovascular events and all-cause mortality in young and middle-aged adults stratified by obesity status. Kaplan-Meier and Cox proportional risk models were used to analyze the data.
+
+ RESULTS: During a follow-up period of 123 months, a high TyG index increased the risk of cardiovascular events by 63% (P = 0.040) and the risk of all-cause mortality by 32% (P = 0.010) in individuals after adjusting for all covariates. High TyG was shown to be linked to cardiovascular events in obese people (Model 3: HR = 2.42, 95% CI = 1.13-5.12, P = 0.020); however, there was no significant difference in TyG groups for nonobese adults in Model 3 (P = 0.08).
+
+ CONCLUSIONS: TyG was independently associated with harmful long-term cardiovascular events in young and middle-aged US populations, with a stronger association observed in those who were obese. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Insulin). IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1186%2fs12944-023-01834-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Association+between+the+insulin+resistance+marker+TyG+index+and+subsequent+adverse+long-term+cardiovascular+events+in+young+and+middle-aged+US+adults+based+on+obesity+status.&volume=22&issue=1&spage=65&epage=&date=2023&doi=10.1186%2Fs12944-023-01834-y&pmid=37202751&sid=OVID:medline
+
+<256>
+Unique Identifier
+ 37189422
+Title
+ Plasma Cytokeratin-18 Fragment Level Reflects the Metabolic Phenotype in Obesity.
+Source
+ Biomolecules. 13(4), 2023 04 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Goralska J; Razny U; Gruca A; Zdzienicka A; Micek A; Dembinska-Kiec A; Solnica B; Malczewska-Malec M
+Author NameID
+ Goralska, Joanna; ORCID: https://orcid.org/0000-0002-9557-8440
+ Micek, Agnieszka; ORCID: https://orcid.org/0000-0001-8557-1774
+Authors Full Name
+ Goralska, Joanna; Razny, Urszula; Gruca, Anna; Zdzienicka, Anna; Micek, Agnieszka; Dembinska-Kiec, Aldona; Solnica, Bogdan; Malczewska-Malec, Malgorzata.
+Institution
+ Goralska, Joanna. Department of Clinical Biochemistry, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
+ Razny, Urszula. Department of Clinical Biochemistry, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
+ Gruca, Anna. Department of Clinical Biochemistry, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
+ Zdzienicka, Anna. Department of Clinical Biochemistry, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
+ Micek, Agnieszka. Institute of Nursing and Midwifery, Jagiellonian University Medical College; Michalowskiego 12, 31-126 Krakow, Poland.
+ Dembinska-Kiec, Aldona. Department of Clinical Biochemistry, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
+ Solnica, Bogdan. Department of Clinical Biochemistry, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
+ Malczewska-Malec, Malgorzata. Department of Clinical Biochemistry, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
+MeSH Subject Headings
+ Humans
+ *Insulin Resistance
+ Keratin-18
+ Biomarkers/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/me [Metabolism]
+ Phenotype
+ gamma-Glutamyltransferase
+ Cytokines/me [Metabolism]
+ Liver/me [Metabolism]
+Keyword Heading
+ CK-18
+ FGF-21
+ cytokeratin-18
+ fatty liver
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ There is growing interest in the non-invasive identification and monitoring of the outcome of liver damage in obese patients. Plasma cytokeratin-18 (CK-18) fragment levels correlate with the magnitude of hepatocyte apoptosis and have recently been proposed to independently predict the presence of non-alcoholic steatohepatitis (NASH). The aim of the study was to analyze the associations of CK-18 with obesity and related complications: insulin resistance, impaired lipid metabolism and the secretion of hepatokines, adipokines and pro-inflammatory cytokines. The study involved 151 overweight and obese patients (BMI 25-40), without diabetes, dyslipidemia or apparent liver disease. Liver function was assessed based on alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT) and the fatty liver index (FLI). CK-18 M30 plasma levels, FGF-21, FGF-19 and cytokines were determined by ELISA. CK-18 values >150 U/l were accompanied by high ALT, GGT and FLI, insulin resistance, postprandial hypertriglyceridemia, elevated FGF-21 and MCP-1 and decreased adiponectin. ALT activity was the strongest independent factor influencing high CK-18 plasma levels, even after an adjustment for age, sex and BMI [beta coefficient (95%CI): 0.40 (0.19-0.61)]. In conclusion, the applied CK-18 cut-off point at 150 U/l allows to distinguish between two metabolic phenotypes in obesity.
+Registry Number/Name of Substance
+ 0 (Keratin-18). 0 (Biomarkers). EC 2-3-2-2 (gamma-Glutamyltransferase). 0 (Cytokines).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fbiom13040675
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Goralska&issn=2218-273X&title=Biomolecules&atitle=Plasma+Cytokeratin-18+Fragment+Level+Reflects+the+Metabolic+Phenotype+in+Obesity.&volume=13&issue=4&spage=&epage=&date=2023&doi=10.3390%2Fbiom13040675&pmid=37189422&sid=OVID:medline
+
+<257>
+Unique Identifier
+ 37175880
+Title
+ Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity.
+Source
+ International Journal of Molecular Sciences. 24(9), 2023 May 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Carmona-Maurici J; Rosa A; Azcona-Granada N; Pena E; Ricart-Jane D; Vinas A; Lopez-Tejero MD; Domingo JC; Minarro A; Baena-Fustegueras JA; Peinado-Onsurbe J; Pardina E
+Author NameID
+ Rosa, Araceli; ORCID: https://orcid.org/0000-0001-6935-3785
+ Domingo, Joan Carles; ORCID: https://orcid.org/0000-0002-6356-0836
+ Pardina, Eva; ORCID: https://orcid.org/0000-0002-0588-1324
+Authors Full Name
+ Carmona-Maurici, Julia; Rosa, Araceli; Azcona-Granada, Natalia; Pena, Elionora; Ricart-Jane, David; Vinas, Anna; Lopez-Tejero, Maria Dolores; Domingo, Joan Carles; Minarro, Antonio; Baena-Fustegueras, Juan Antonio; Peinado-Onsurbe, Julia; Pardina, Eva.
+Institution
+ Carmona-Maurici, Julia. Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028 Barcelona, Spain.
+ Rosa, Araceli. Seccio de Zoologia i Antropologia Biologica, Departament de Biologia Evolutiva Ecologia i Ciencies Ambientals Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.
+ Rosa, Araceli. Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028 Barcelona, Spain.
+ Rosa, Araceli. Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto de Salud Carlos III, 28029 Barcelona, Spain.
+ Azcona-Granada, Natalia. Seccio de Zoologia i Antropologia Biologica, Departament de Biologia Evolutiva Ecologia i Ciencies Ambientals Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.
+ Pena, Elionora. Seccio de Zoologia i Antropologia Biologica, Departament de Biologia Evolutiva Ecologia i Ciencies Ambientals Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.
+ Ricart-Jane, David. Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028 Barcelona, Spain.
+ Vinas, Anna. Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028 Barcelona, Spain.
+ Lopez-Tejero, Maria Dolores. Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028 Barcelona, Spain.
+ Domingo, Joan Carles. Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028 Barcelona, Spain.
+ Minarro, Antonio. Departament de Genetica, Microbiologia i Estadistica, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.
+ Baena-Fustegueras, Juan Antonio. Gastrointestinal Surgery Department, Arnau de Vilanova University Hospital, IRB Lleida, University of Lleida, 25198 Lleida, Spain.
+ Peinado-Onsurbe, Julia. Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028 Barcelona, Spain.
+ Pardina, Eva. Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028 Barcelona, Spain.
+MeSH Subject Headings
+ Humans
+ Obesity, Morbid/co [Complications]
+ Obesity, Morbid/ge [Genetics]
+ *Obesity, Morbid
+ Fibronectins/ge [Genetics]
+ Plaque, Atherosclerotic/di [Diagnosis]
+ Plaque, Atherosclerotic/ge [Genetics]
+ *Plaque, Atherosclerotic
+ Carotid Intima-Media Thickness
+ Obesity
+ Atherosclerosis/di [Diagnosis]
+ Atherosclerosis/ge [Genetics]
+ *Atherosclerosis
+ Biomarkers
+Keyword Heading
+ FNDC5 gene
+ bariatric surgery
+ genetic variability
+ irisin
+ metabolic disorders
+ rs3480
+ severe obesity
+ subclinical atherosclerosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Severe obesity (SO) can accelerate atherosclerosis and the onset of acute cardiovascular events. The diagnosis of atherosclerosis in the context of a high body mass index (BMI) can be challenging, making the identification of biomarkers clinically relevant. We aimed to assess the usefulness of irisin as a biomarker for subclinical atherosclerosis in participants with SO. This prospective observational study included 61 participants undergoing bariatric surgery for SO, defined as a BMI >40 kg/m2 or >35 kg/m2 with at least one comorbidity. Atherosclerotic plaques were detected by ultrasound. Plasma samples were obtained 1 month before and at 6 and 12 months after bariatric surgery to measure irisin by ELISA. Additionally, subcutaneous samples of adipose tissue were taken and genotyped to identify irisin polymorphism rs3480. Irisin levels were positively correlated with BMI (r = 0.23, p = 0.0064), negatively correlated with atheroma-related parameters (e.g., carotid intima-media thickness), and lower in subjects with atheroma (p < 0.0002). Irisin also showed good overall accuracy for discriminating plaque presence (AUC, 0.81; 95% CI, 0.6956-0.9156). However, the rs3480 polymorphism correlated with neither the irisin levels nor the presence of atheromas. Iirisin could identify subclinical atherosclerosis in SO and might facilitate clinical diagnosis.
+Registry Number/Name of Substance
+ 0 (Fibronectins). 0 (Biomarkers).
+Publication Type
+ Observational Study. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fijms24098171
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Carmona-Maurici&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Irisin+as+a+Novel+Biomarker+of+Subclinical+Atherosclerosis+in+Severe+Obesity.&volume=24&issue=9&spage=8171&epage=&date=2023&doi=10.3390%2Fijms24098171&pmid=37175880&sid=OVID:medline
+
+<258>
+Unique Identifier
+ 37166403
+Title
+ Hedgehog interacting protein as a circulating biomarker in women with obesity: a cross-sectional study and intervention studies.
+Source
+ Annals of Medicine. 55(1):2206162, 2023 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang H; Wang Y; Zhang H; Liang Z; Hu W; Qiu S; Li K; Zhang L; Dai H; Yang M; Yang G; Li L
+Authors Full Name
+ Wang, Hao; Wang, Yanping; Zhang, Hongmin; Liang, Zerong; Hu, Wenjing; Qiu, Sheng; Li, Ke; Zhang, Lili; Dai, Han; Yang, Mengliu; Yang, Gangyi; Li, Ling.
+Institution
+ Wang, Hao. The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
+ Wang, Hao. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Wang, Yanping. The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
+ Wang, Yanping. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Zhang, Hongmin. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Zhang, Hongmin. Department of Endocrinology, The First People's Hospital of Chongqing Liang Jiang New Area, Chongqing, China.
+ Liang, Zerong. Department of Endocrinology, Chongqing Red Cross Hospital (People's Hospital of Jiangbei District), Chongqing, China.
+ Hu, Wenjing. The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
+ Qiu, Sheng. The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
+ Li, Ke. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Zhang, Lili. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Dai, Han. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Yang, Mengliu. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Yang, Gangyi. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Li, Ling. The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
+MeSH Subject Headings
+ Female
+ Humans
+ Biomarkers
+ Blood Glucose/me [Metabolism]
+ Cohort Studies
+ Cross-Sectional Studies
+ Hedgehog Proteins/bl [Blood]
+ *Hedgehog Proteins
+ Insulin/me [Metabolism]
+ *Insulin Resistance
+ Liraglutide
+ Metformin/tu [Therapeutic Use]
+ *Metformin
+ Obesity/di [Diagnosis]
+ *Obesity
+Keyword Heading
+ Hedgehog interacting protein
+ bioinformatics
+ insulin resistance
+ intervention study
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although a study found a significant increase in serum hedgehog interacting protein (HHIP) concentrations in impaired fasting blood glucose, impaired glucose tolerance and newly diagnosed T2DM patients, the variation in circulating HHIP levels in obese individuals remains unknown.
+
+ PATIENTS AND METHODS: Gene Set Enrichment Analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were used for differentially expressed genes and signal pathways. The study is comprised of a total of 452 young women, including 248 obese individuals and 204 controls. Circulating HHIP and Adipoq levels were determined with ELISA kits. Euglycemic-hyperinsulinemic clamps (EHC) and oral glucose tolerance test (OGTT) were conducted in every subject. 32 women were given metformin and 49 were given liraglutide treatment for 6 weeks. The study was registered with www.chictr.org.cn (ChiCTR2000032878 and ChiCTR1800019776).
+
+ RESULTS: Obesity was significantly associated with the cAMP signal pathway, and HHIP was a secreted protein related to cAMP signalling, as determined by KEGG analysis. In this population-based cohort study, we found that the level of circulating HHIP was significantly elevated in obese women, and positively correlated with body mass index and blood glucose, blood lipid, insulin, homeostasis model assessment of insulin resistance, dehydroepiandrostenedione sulphate, and luteinizing hormone, while negatively correlated with M-value and Adipoq. Insulin resistance (IR) and ove TMrweight/obesity were associated with the higher HHIP concentration. OGTT and EHC tests revealed that the levels of circulating HHIP were regulated by blood glucose but to a less extent by insulin. After therapy with metformin and liraglutide, circulating HHIP levels were decreased, whereas Adipoq levels increased significantly.
+
+ CONCLUSIONS: Our findings support HHIP as a potential biomarker for predicting obesity and IR. In addition, drugs targeting HHIP may be a new strategy to treat obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hedgehog Proteins). 0 (Insulin). 839I73S42A (Liraglutide). 9100L32L2N (Metformin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1080%2f07853890.2023.2206162
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0785-3890&title=Annals+of+Medicine&atitle=Hedgehog+interacting+protein+as+a+circulating+biomarker+in+women+with+obesity%3A+a+cross-sectional+study+and+intervention+studies.&volume=55&issue=1&spage=2206162&epage=&date=2023&doi=10.1080%2F07853890.2023.2206162&pmid=37166403&sid=OVID:medline
+
+<259>
+Unique Identifier
+ 37165483
+Title
+ Assessing adipokines as potential biomarkers of dementia, Alzheimer's disease, and mild cognitive impairment: A systematic review and meta-analysis. [Review]
+Source
+ Obesity Reviews. 24(8):e13573, 2023 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Garcia-Garcia I; Fernandez-Andujar M; Narvaez M; Garcia-Casares N
+Author NameID
+ Garcia-Garcia, Isabel; ORCID: https://orcid.org/0000-0002-5873-2664
+ Fernandez-Andujar, Marina; ORCID: https://orcid.org/0000-0002-1336-1820
+Authors Full Name
+ Garcia-Garcia, Isabel; Fernandez-Andujar, Marina; Narvaez, Manuel; Garcia-Casares, Natalia.
+Institution
+ Garcia-Garcia, Isabel. Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
+ Fernandez-Andujar, Marina. Faculty of Psychology, Abat Oliba CEU University, CEU Universities, Barcelona, Spain.
+ Narvaez, Manuel. Faculty of Medicine, University of Malaga, Malaga, Spain.
+ Narvaez, Manuel. Clinical Neurology Unit, Medical-Health Research Center (CIMES), University of Malaga, Malaga, Spain.
+ Garcia-Casares, Natalia. Faculty of Medicine, University of Malaga, Malaga, Spain.
+ Garcia-Casares, Natalia. Clinical Neurology Unit, Medical-Health Research Center (CIMES), University of Malaga, Malaga, Spain.
+ Garcia-Casares, Natalia. Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain.
+MeSH Subject Headings
+ Humans
+ Adipokines
+ Alzheimer Disease/di [Diagnosis]
+ *Alzheimer Disease
+ Leptin
+ Resistin
+ Adiponectin
+ Ghrelin
+ Cross-Sectional Studies
+ Prospective Studies
+ Cognitive Dysfunction/di [Diagnosis]
+ Cognitive Dysfunction/cf [Cerebrospinal Fluid]
+ *Cognitive Dysfunction
+ Biomarkers
+ Obesity
+Keyword Heading
+ adipokines
+ gastrointestinal hormones
+ ghrelin
+ neurodegeneration
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Midlife obesity and late-life weight loss confer a greater risk for developing dementia and Alzheimer's disease (AD), but the exact mechanisms behind this phenomenon are currently unknown. The answer could lie on the involvement of gastrointestinal factors, such as adipokines (e.g., leptin, adiponectin, and resistin) and ghrelin. In this context, we conducted a pre-registered systematic review and meta-analysis of 42 cross-sectional and 13 longitudinal studies targeting the associations between leptin, adiponectin, resistin, and ghrelin and the prevalence of general dementia, AD, and mild cognitive impairment (MCI). We also examined the relationship between the four gastrointestinal factors and neurocognitive outcomes and AD-related cerebrospinal fluid biomarkers. Patients with AD had lower blood leptin and higher resistin levels than cognitively normal participants. Lower leptin and higher resistin were associated with higher degree of cognitive impairment. Additionally, lower late-life leptin levels might be associated with higher prospective risk of dementia and AD, although more studies are needed to corroborate this. Results in ghrelin and adiponectin were not conclusive, with age, sex distribution, obesity, and severity of dementia seemingly acting as moderators across several analyses. Our work might contribute to the identification of new preclinical blood markers of MCI and AD. Copyright © 2023 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Leptin). 0 (Resistin). 0 (Adiponectin). 0 (Ghrelin). 0 (Biomarkers).
+Publication Type
+ Meta-Analysis. Systematic Review. Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1111%2fobr.13573
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Garcia-Garcia&issn=1467-7881&title=Obesity+Reviews&atitle=Assessing+adipokines+as+potential+biomarkers+of+dementia%2C+Alzheimer%27s+disease%2C+and+mild+cognitive+impairment%3A+A+systematic+review+and+meta-analysis.&volume=24&issue=8&spage=e13573&epage=&date=2023&doi=10.1111%2Fobr.13573&pmid=37165483&sid=OVID:medline
+
+<260>
+Unique Identifier
+ 37147659
+Title
+ Inflammatory biomarkers in overweight and obese Iranian women are associated with polyphenol intake.
+Source
+ Journal of Health, Population & Nutrition. 42(1):39, 2023 05 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shiraseb F; Hosseininasab D; Noori S; Ebrahimi S; Asjodi F; Ghaffarian-Ensaf R; Carnauba RA; Mirzaei K
+Authors Full Name
+ Shiraseb, Farideh; Hosseininasab, Dorsa; Noori, Sahar; Ebrahimi, Sara; Asjodi, Foad; Ghaffarian-Ensaf, Rasool; Carnauba, Renata A; Mirzaei, Khadijeh.
+Institution
+ Shiraseb, Farideh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Hosseininasab, Dorsa. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
+ Noori, Sahar. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
+ Ebrahimi, Sara. The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, Melbourne, VIC, Australia.
+ Asjodi, Foad. IFMARK, FIFA Medical Center of Excellence, Tehran, Iran.
+ Ghaffarian-Ensaf, Rasool. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
+ Carnauba, Renata A. Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
+ Carnauba, Renata A. Food Research Center, CEPID-FAPESP (Research Innovation and Dissemination Centers, Sao Paulo Research Foundation), Sao Paulo, Brazil.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran. mirzaei_kh@sina.tums.ac.ir.
+ Mirzaei, Khadijeh. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. mirzaei_kh@sina.tums.ac.ir.
+MeSH Subject Headings
+ Female
+ Humans
+ Male
+ Overweight/co [Complications]
+ *Overweight
+ Iran
+ *Polyphenols
+ Cross-Sectional Studies
+ Obesity/co [Complications]
+ Biomarkers
+ Body Mass Index
+ Inflammation
+ Cholesterol
+ Transforming Growth Factor beta
+Keyword Heading
+ C-reactive protein
+ Inflammation
+ Obesity
+ Polyphenols
+ TGF-beta
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The evidence shows that obesity is associated with chronic inflammation in obese subjects. Polyphenols are a complex group of plant secondary metabolites that may play a role in reducing the risk of obesity and obesity-related diseases. Given the scarcity of evidence on the association between inflammatory markers and dietary polyphenols intake in overweight/obese Iranian women, the current study aims to investigate this link.
+
+ METHOD: The present cross-sectional study was conducted on 391 overweight and obese Iranian women aged 18-48 years (body mass index (BMI) >= 25 kg/m2). A 147-item food frequency questionnaire (FFQ) was used to assess dietary intake, as well as anthropometric indices including weight, height, waist circumference (WC), and hip circumference (HC) and biochemistry parameters including triglyceride (TG), total cholesterol (Chole), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT), galactin-3 (Gal-3), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor beta (TGF-beta), interleukin-1 beta (IL_1beta), plasminogen activator inhibitor-1 (PA-I), serum leptin concentrations, and C-reactive protein of high sensitivity (hs-CRP) in all participants. The inflammatory markers were assessed using the enzyme-linked immunosorbent assay (ELISA).
+
+ RESULT: The findings revealed a significant negative association between flavonoids intake and MCP-1 (P = 0.024), lignans intake and MCP-1 (P = 0.017), and Gal-3 (P = 0.032). These significant associations were observed between other polyphenols intake and IL_1beta (P = 0.014). There was also a significant positive association between other polyphenol intake and TGF-beta (P = 0.008) and between phenolic acid intake and TGF-beta (P = 0.014).
+
+ CONCLUSION: Our findings suggest that a high polyphenol intake may help individuals to reduce systemic inflammation. Further large studies involving participants of different ages and genders are highly warranted. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Polyphenols). 0 (Biomarkers). 97C5T2UQ7J (Cholesterol). 0 (Transforming Growth Factor beta).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1186%2fs41043-023-00376-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shiraseb&issn=1606-0997&title=Journal+of+Health%2C+Population+%26+Nutrition&atitle=Inflammatory+biomarkers+in+overweight+and+obese+Iranian+women+are+associated+with+polyphenol+intake.&volume=42&issue=1&spage=39&epage=&date=2023&doi=10.1186%2Fs41043-023-00376-4&pmid=37147659&sid=OVID:medline
+
+<261>
+Unique Identifier
+ 37137183
+Title
+ Divya-WeightGo combined with moderate aerobic exercise remediates adiposopathy, insulin resistance, serum biomarkers, and hepatic lipid accumulation in high-fat diet-induced obese mice.
+Source
+ Biomedicine & Pharmacotherapy. 163:114785, 2023 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Balkrishna A; Sharma S; Maity M; Tomer M; Singh R; Gohel V; Dev R; Sinha S; Varshney A
+Authors Full Name
+ Balkrishna, Acharya; Sharma, Sonam; Maity, Madhulina; Tomer, Meenu; Singh, Rani; Gohel, Vivek; Dev, Rishabh; Sinha, Sandeep; Varshney, Anurag.
+Institution
+ Balkrishna, Acharya. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India; Department of Allied and Applied Sciences, University of Patanjali, Haridwar, India; Patanjali UK Trust, Glasgow, United Kingdom; Vedic Acharya Samaj Foundation, Inc. NFP, 21725 CR 33, Groveland, FL 34736, USA.
+ Sharma, Sonam. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
+ Maity, Madhulina. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
+ Tomer, Meenu. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
+ Singh, Rani. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
+ Gohel, Vivek. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
+ Dev, Rishabh. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
+ Sinha, Sandeep. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.
+ Varshney, Anurag. Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India; Department of Allied and Applied Sciences, University of Patanjali, Haridwar, India; Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi, India. Electronic address: anurag@patanjali.res.in.
+MeSH Subject Headings
+ Mice
+ Animals
+ Mice, Obese
+ *Insulin Resistance
+ Diet, High-Fat/ae [Adverse Effects]
+ Anti-Obesity Agents/pd [Pharmacology]
+ Anti-Obesity Agents/tu [Therapeutic Use]
+ *Anti-Obesity Agents
+ Obesity/me [Metabolism]
+ Liver
+ Triglycerides
+ Biomarkers/me [Metabolism]
+ Mice, Inbred C57BL
+ 3T3-L1 Cells
+Keyword Heading
+ Adiposopathy
+ Anti-inflammatory
+ Divya-WeightGo
+ Exercise
+ High fat diet-induced obesity
+ Lipid accumulation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity has become an unprecedented epidemic worldwide owing to a prolonged imbalance between energy intake and expenditure. Available therapies primarily suppress energy intake but often fail to produce sustained fat loss, necessitating a more efficacious strategy to combat obesity. In this study, a polyherbal formulation, Divya-WeightGo (DWG) has been investigated for its anti-obesity activity using in-vitro and in-vivo assays. Ultra-high performance liquid chromatography (UHPLC) analysis revealed the presence of phytocompounds including gallic acid, methyl gallate, corilagin, ellagic acid, pentagalloyl glucose, withaferin A and hydroxycitric acid, proven to aid in weight loss. The exposure of 3T3-L1 cells to DWG at cytosafe concentrations inhibited lipid and triglyceride accumulation and downregulated the expression of several adipogenic and lipogenic markers like PPARy, C/EBPalpha, C/EBPbeta, SREBP-1c, FASN and DGAT1. DWG reduced LPS-induced pro-inflammatory cytokine release and NF-kappaB activity in THP-1 cells. The in-vivo anti-obesity activity of DWG, both alone and in combination with moderate aerobic exercise, was assessed in a high fat diet-induced obese mouse model. DWG mitigated the obesity associated increased body weight gain, feed efficiency ratio, glucose intolerance, diminished insulin sensitivity, dyslipidemia, altered liver function profile, lipid accumulation and adiposopathy in obese mice, alone as well as in combination intervention, with better efficacy in the combination approach. Thus, the findings of this study suggest that DWG could be a promising therapeutic avenue to treat obesity through attenuation of lipid and fat accumulation in liver and adipose tissues and could be utilized as an adjunct with lifestyle interventions to combat obesity and associated complications. Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.biopha.2023.114785
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Balkrishna&issn=0753-3322&title=Biomedicine+%26+Pharmacotherapy&atitle=Divya-WeightGo+combined+with+moderate+aerobic+exercise+remediates+adiposopathy%2C+insulin+resistance%2C+serum+biomarkers%2C+and+hepatic+lipid+accumulation+in+high-fat+diet-induced+obese+mice.&volume=163&issue=&spage=114785&epage=&date=2023&doi=10.1016%2Fj.biopha.2023.114785&pmid=37137183&sid=OVID:medline
+
+<262>
+Unique Identifier
+ 37127240
+Title
+ The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure.
+Source
+ Journal of Cardiac Failure. 29(8):1121-1131, 2023 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Horiuchi YU; Wettersten N; Vanveldhuisen DJ; Mueller C; Nowak R; Hogan C; Kontos MC; Cannon CM; Birkhahn R; Vilke GM; Mahon N; Nunez J; Briguori C; Duff S; Murray PT; Maisel A
+Authors Full Name
+ Horiuchi, Y U; Wettersten, Nicholas; Vanveldhuisen, Dirk J; Mueller, Christian; Nowak, Richard; Hogan, Christopher; Kontos, Michael C; Cannon, Chad M; Birkhahn, Robert; Vilke, Gary M; Mahon, Niall; Nunez, Julio; Briguori, Carlo; Duff, Stephen; Murray, Patrick T; Maisel, Alan.
+Institution
+ Horiuchi, Y U. Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
+ Wettersten, Nicholas. Division of Cardiovascular Medicine, San Diego Veterans Affairs Medical Center, San Diego, CA, USA; Division of Cardiovascular Medicine, University of California, San Diego, La Jolla, CA, USA.
+ Vanveldhuisen, Dirk J. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
+ Mueller, Christian. Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Nowak, Richard. Department of Emergency Medicine, Henry Ford Hospital System, Detroit, MI; USA.
+ Hogan, Christopher. Division of Emergency Medicine and Acute Care Surgical Services, VCU Medical Center, Virginia Commonwealth University, Richmond, VA, USA.
+ Kontos, Michael C. Division of Cardiology, VCU Medical Center, Virginia Commonwealth University, Richmond, VA.
+ Cannon, Chad M. Department of Emergency Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
+ Birkhahn, Robert. Department of Emergency Medicine, New York Methodist Hospital, Brooklyn, NY, USA.
+ Vilke, Gary M. Department of Emergency Medicine, University of California, San Diego, La Jolla, CA, USA.
+ Mahon, Niall. School of Medicine, University College Dublin, Dublin, Ireland.
+ Nunez, Julio. Department of Cardiology, Hospital Clinico Universitario Valencia, INCLIVA, University of Valencia, Valencia, Spain and CIBER in Cardiovascular Diseases, Madrid, Spain.
+ Briguori, Carlo. Department of Cardiology, Interventional Cardiology, Mediterranea Cardiocentro, Naples, Italy.
+ Duff, Stephen. School of Medicine, University College Dublin, Dublin, Ireland.
+ Murray, Patrick T. School of Medicine, University College Dublin, Dublin, Ireland.
+ Maisel, Alan. Division of Cardiovascular Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: asmaisel@gmail.com.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Humans
+ Lipocalin-2
+ *Heart Failure
+ Body Mass Index
+ Galectin 3
+ Biomarkers
+ Prognosis
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Natriuretic Peptide, Brain
+Keyword Heading
+ acute heart failure
+ biomarker
+ body mass index
+ cardiac troponin
+ natriuretic peptide
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Body mass index (BMI) is a known confounder for natriuretic peptides, but its influence on other biomarkers is less well described. We investigated whether BMI interacts with biomarkers' association with prognosis in patients with acute heart failure (AHF).
+
+ METHODS AND RESULTS: B-type natriuretic peptide (BNP), high-sensitivity cardiac troponin I (hs-cTnI), galectin-3, serum neutrophil gelatinase-associated lipocalin (sNGAL), and urine NGAL were measured serially in patients with AHF during hospitalization in the AKINESIS (Acute Kidney Injury Neutrophil gelatinase-associated lipocalin Evaluation of Symptomatic Heart Failure) study. Cox regression analysis was used to determine the association of biomarkers and their interaction with BMI for 30-day, 90-day and 1-year composite outcomes of death or HF readmission. Among 866 patients, 21.2%, 29.7% and 46.8% had normal (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2) or obese (>= 30 kg/m2) BMIs on admission, respectively. Admission values of BNP and hs-cTnI were negatively associated with BMI, whereas galectin-3 and sNGAL were positively associated with BMI. Admission BNP and hs-cTnI levels were associated with the composite outcome within 30 days, 90 days and 1 year. Only BNP had a significant interaction with BMI. When BNP was analyzed by BMI category, its association with the composite outcome attenuated at higher BMIs and was no longer significant in obese individuals. Findings were similar when evaluated by the last-measured biomarkers and BMIs.
+
+ CONCLUSIONS: In patients with AHF, only BNP had a significant interaction with BMI for the outcomes, with its association attenuating as BMI increased; hs-cTnI was prognostic, regardless of BMI. Copyright © 2023. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Lipocalin-2). 0 (Galectin 3). 0 (Biomarkers). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.cardfail.2023.03.029
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Horiuchi&issn=1071-9164&title=Journal+of+Cardiac+Failure&atitle=The+Influence+of+Body+Mass+Index+on+Clinical+Interpretation+of+Established+and+Novel+Biomarkers+in+Acute+Heart+Failure.&volume=29&issue=8&spage=1121&epage=1131&date=2023&doi=10.1016%2Fj.cardfail.2023.03.029&pmid=37127240&sid=OVID:medline
+
+<263>
+Unique Identifier
+ 37127141
+Title
+ Artemisia annua L. (Sweet wormwood) leaf extract attenuates high-fat diet-induced testicular dysfunctions and improves spermatogenesis in obese rats.
+Source
+ Journal of Ethnopharmacology. 313:116528, 2023 Sep 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ El-Sawy SA; Amin YA; El-Naggar SA; Abdelsadik A
+Authors Full Name
+ El-Sawy, Samer A; Amin, Yahia A; El-Naggar, Sabry A; Abdelsadik, Ahmed.
+Institution
+ El-Sawy, Samer A. Medical Biochemistry Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
+ Amin, Yahia A. Theriogenology Department, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt. Electronic address: yahiaamin2030@gmail.com.
+ El-Naggar, Sabry A. Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
+ Abdelsadik, Ahmed. Zoology Department, Faculty of Science, Aswan University, Aswan, Egypt; Laboratory of Immunometabolism, Aswan University, Egypt.
+MeSH Subject Headings
+ Male
+ Humans
+ Rats
+ Animals
+ *Artemisia annua
+ Diet, High-Fat/ae [Adverse Effects]
+ Orlistat/me [Metabolism]
+ Orlistat/pd [Pharmacology]
+ Orlistat/tu [Therapeutic Use]
+ Plant Extracts/pd [Pharmacology]
+ Plant Extracts/tu [Therapeutic Use]
+ Plant Extracts/me [Metabolism]
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Antioxidants/pd [Pharmacology]
+ Antioxidants/tu [Therapeutic Use]
+ Antioxidants/me [Metabolism]
+ Spermatogenesis
+ Oxidative Stress
+ Testis/me [Metabolism]
+ Testicular Diseases/me [Metabolism]
+ *Testicular Diseases
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ Apoptosis
+ Artemisia annua
+ Azoospermia
+ High-fat diet
+ Male infertility
+ Obesity
+ Orlistat
+ Proliferating cell nuclear antigen
+ Sweet wormwood
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia annua L., known as "sweet wormwood," is widely used in Egyptian folk medicine. Egyptians implement the aerial parts in the treatment of respiratory, digestive and sexual dysfunctions. However, the mechanism by which Artemisia annua improves testicular function is still being discovered.
+
+ AIM OF THE STUDY: This study aimed to evaluate the modulatory effects of the crude leaf extract of Artemisia annua (AAE) on a high-fat diet induced testicular dysfunction in rats and compare it with the antilipolytic drug Orlistat.
+
+ MATERIAL AND METHODS: Forty adult rats were randomly classified and assigned to four groups. The first group typically consumed a balanced diet and served as a negative control (GP1). A high-fat diet-induced obesity was applied to the other three groups for 12 weeks. A positive control remained on HFD for another 8 weeks, which is GP2. Other groups were administered for 8 consecutive weeks either with Orlistat (50 mg/kg body weight) or AAE (100 mg/kg body weight), which have been defined as GP3 and GP4, respectively. Testosterone (TST), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were determined in the sera of all groups. In addition, the oxidant/antioxidant biomarkers such as protein carbonyl, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) activities, lactate dehydrogenase (LDH) and creatine kinase isoenzyme-B (CK-MB) were determined. An immunohistochemical stain with the apoptotic marker caspase-3 and the proliferating cell nuclear antigen (PCNA) were also investigated.
+
+ RESULTS: In the testes of the obese group, the results showed hormonal imbalance, an increase in oxidative stress biomarkers and apoptosis. In the group treated with orlistat (GP3), noticeably more perturbations were noted. The obese rats that had been treated with AAE (GP4) showed a significantly reduced level of oxidative stress, hormonal balance restoration and reduced apoptosis.
+
+ CONCLUSIONS: The crude leaf extract of A. annua is a potential herbal therapeutic for the treatment of obesity-related testicular dysfunction and the restoration of hormonal imbalance in obese rats. Copyright © 2023 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 95M8R751W8 (Orlistat). 81746-15-8 (GP 4). 0 (Plant Extracts). 0 (Antioxidants). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.jep.2023.116528
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=El-Sawy&issn=0378-8741&title=Journal+of+Ethnopharmacology&atitle=Artemisia+annua+L.+%28Sweet+wormwood%29+leaf+extract+attenuates+high-fat+diet-induced+testicular+dysfunctions+and+improves+spermatogenesis+in+obese+rats.&volume=313&issue=&spage=116528&epage=&date=2023&doi=10.1016%2Fj.jep.2023.116528&pmid=37127141&sid=OVID:medline
+
+<264>
+Unique Identifier
+ 37121824
+Title
+ Adiposity and plasma concentrations of kynurenine pathway metabolites and traditional markers of inflammation.
+Source
+ Obesity Research & Clinical Practice. 17(3):203-209, 2023 May-Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang ME; Hodge AM; Li SX; Southey MC; Giles GG; Dugue PA
+Authors Full Name
+ Wang, Mengmei E; Hodge, Allison M; Li, Sherly X; Southey, Melissa C; Giles, Graham G; Dugue, Pierre-Antoine.
+Institution
+ Wang, Mengmei E. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
+ Hodge, Allison M. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
+ Li, Sherly X. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
+ Southey, Melissa C. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, Australia.
+ Giles, Graham G. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
+ Dugue, Pierre-Antoine. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia. Electronic address: pierre-antoine.dugue@monash.edu.
+MeSH Subject Headings
+ Middle Aged
+ Humans
+ Aged
+ Kynurenine/me [Metabolism]
+ *Kynurenine
+ Tryptophan/me [Metabolism]
+ *Tryptophan
+ Cohort Studies
+ Adiposity
+ Quinolinic Acid
+ Cross-Sectional Studies
+ Inflammation
+ Obesity
+ Biomarkers
+Keyword Heading
+ Aging
+ Body composition
+ Body size
+ Inflammation
+ Tryptophan kynurenine pathway
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: The kynurenine pathway is increasingly recognised to play a role in inflammation and disease. We assessed the cross-sectional and longitudinal associations of adiposity measures (body mass index, waist-hip ratio, waist circumference and fat mass ratio) with plasma concentrations of kynurenine pathway metabolites and traditional markers of inflammation.
+
+ METHODS: We used data from 970 Melbourne Collaborative Cohort Study participants who had plasma markers measured at baseline (median age 59 years) and follow-up (median age 70 years). Linear regression was used to assess cross-sectional and longitudinal associations between four adiposity measures and concentrations of i) nine kynurenine pathway metabolites; ii) two derived markers; iii) eight traditional inflammatory markers.
+
+ RESULTS: Cross-sectionally, most kynurenine metabolites were strongly associated with adiposity measures at both time points; associations were generally stronger than for most inflammation markers except CRP (e.g. body mass index at baseline, quinolinic acid (per S.D. beta = 0.30, 95%CI: 0.24-0.36, P = 10-21), kynurenine (beta = 0.25, 95%CI: 0.19-0.31, P = 10-16) and CRP (beta = 0.31, 95%CI: 0.25-0.37, P = 10-24), and remained largely unchanged after adjustment for confounders. Longitudinally, changes in adiposity measures over approximately a decade were positively associated with changes in kynurenine metabolite concentrations (in particular for 3-hydroxyanthranilic acid, kynurenine and quinolinic acid), and more strongly so than for other markers of inflammation, including CRP.
+
+ CONCLUSIONS: In middle-aged and older adults, plasma concentrations of kynurenine metabolites are strongly associated with adiposity, both cross-sectionally and longitudinally. Our study demonstrates that kynurenine metabolites may be valuable markers to monitor the adverse consequences of obesity. Copyright © 2023. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 343-65-7 (Kynurenine). 8DUH1N11BX (Tryptophan). F6F0HK1URN (Quinolinic Acid). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.orcp.2023.04.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1871-403X&title=Obesity+Research+%26+Clinical+Practice&atitle=Adiposity+and+plasma+concentrations+of+kynurenine+pathway+metabolites+and+traditional+markers+of+inflammation.&volume=17&issue=3&spage=203&epage=209&date=2023&doi=10.1016%2Fj.orcp.2023.04.004&pmid=37121824&sid=OVID:medline
+
+<265>
+Unique Identifier
+ 37104052
+Title
+ Oxidative Stress Biomarkers in Mexican Subjects with Overweight and Obesity: A Systematic Review. [Review]
+Source
+ Metabolic Syndrome & Related Disorders. 21(4):188-196, 2023 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gutierrez-Solis AL; Garrido-Dzib AG; Rochel-Perez A; Magallon-Zertuche V; Chavez-Loria G; Medina-Vera I; Avila-Nava A
+Author NameID
+ Medina-Vera, Isabel; ORCID: https://orcid.org/0000-0003-4027-2329
+ Avila-Nava, Azalia; ORCID: https://orcid.org/0000-0003-3363-1477
+Authors Full Name
+ Gutierrez-Solis, Ana Ligia; Garrido-Dzib, Angel Gabriel; Rochel-Perez, Andrea; Magallon-Zertuche, Valeria; Chavez-Loria, Geovanni; Medina-Vera, Isabel; Avila-Nava, Azalia.
+Institution
+ Gutierrez-Solis, Ana Ligia. Hospital Regional de Alta Especialidad de la Peninsula de Yucatan (HRAEPY), Merida, Mexico.
+ Garrido-Dzib, Angel Gabriel. Hospital Regional de Alta Especialidad de la Peninsula de Yucatan (HRAEPY), Merida, Mexico.
+ Garrido-Dzib, Angel Gabriel. Facultad de Medicina, Universidad Autonoma de Yucatan (UADY), Merida, Mexico.
+ Rochel-Perez, Andrea. Hospital Regional de Alta Especialidad de la Peninsula de Yucatan (HRAEPY), Merida, Mexico.
+ Rochel-Perez, Andrea. Becario de la Direccion General de Calidad y Educacion en Salud (DGCES), Secretaria de Salud, Ciudad de Mexico, Mexico.
+ Magallon-Zertuche, Valeria. Hospital Regional de Alta Especialidad de la Peninsula de Yucatan (HRAEPY), Merida, Mexico.
+ Magallon-Zertuche, Valeria. Becario de la Direccion General de Calidad y Educacion en Salud (DGCES), Secretaria de Salud, Ciudad de Mexico, Mexico.
+ Chavez-Loria, Geovanni. Hospital Regional de Alta Especialidad de la Peninsula de Yucatan (HRAEPY), Merida, Mexico.
+ Medina-Vera, Isabel. Departamento de Metodologia de la Investigacion, Instituto Nacional de Pediatria (INP), Ciudad de Mexico, Mexico.
+ Avila-Nava, Azalia. Hospital Regional de Alta Especialidad de la Peninsula de Yucatan (HRAEPY), Merida, Mexico.
+MeSH Subject Headings
+ Humans
+ Overweight/ep [Epidemiology]
+ *Overweight
+ Mexico/ep [Epidemiology]
+ Body Mass Index
+ Obesity/ep [Epidemiology]
+ Obesity/pc [Prevention & Control]
+ *Obesity
+ Weight Gain
+ Biomarkers
+ Oxidative Stress
+Keyword Heading
+ Mexico
+ biomarkers
+ obesity
+ overweight
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: An excess accumulation of adipose tissue in the body is an indication of overweight (OW) and obesity (OB). In Mexico, excess body weight is a public health concern due to the high prevalence of OW and OB. In the last few years, evidence has linked oxidative stress (OS) to excess body weight. It is necessary to understand this relationship to generate strategies for the prevention of OW and OB in the Mexican population. This systematic review focuses on identifying differences in OS biomarkers in the Mexican population with excess body weight in comparison to the population with normal body weight. Methods: A systematic review was performed. The studies were identified through the MEDLINE/PubMed, Web of Science, Cochrane, Scielo, and Liliacs online databases, and the gray literature in Google Scholar. The key words used were "overweight," "obesity," "Mexico," and "oxidative stress." Results: Four studies were selected; the studies were performed in rural and urban areas of Mexico. Malondialdehyde (MDA) and oxidized low-density lipoprotein (ox-LDL) were the OS biomarkers that were increased in the population with excess body weight compared to subjects with normal body weight. Conclusion: According to the included studies, MDA and LDL-ox increased significantly, while the increase in the levels of circulating lipids was enhanced by the excess adipose tissue present in individuals with OW and OB.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Systematic Review. Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1089%2fmet.2023.0001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gutierrez-Solis&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Oxidative+Stress+Biomarkers+in+Mexican+Subjects+with+Overweight+and+Obesity%3A+A+Systematic+Review.&volume=21&issue=4&spage=188&epage=196&date=2023&doi=10.1089%2Fmet.2023.0001&pmid=37104052&sid=OVID:medline
+
+<266>
+Unique Identifier
+ 37084871
+Title
+ Dietary Inflammatory Patterns Are Associated With Serum TGs and Insulin in Adults: A Community-Based Study in Taiwan.
+Source
+ Journal of Nutrition. 153(6):1783-1792, 2023 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chuang SC; Wu IC; Hsiung CA; Chan HT; Cheng CW; Chen HL; Chiu YF; Lee MM; Chang HY; Hsu CC
+Authors Full Name
+ Chuang, Shu-Chun; Wu, I-Chien; Hsiung, Chao Agnes; Chan, Huei-Ting; Cheng, Chiu-Wen; Chen, Hui-Ling; Chiu, Yen-Feng; Lee, Marion M; Chang, Hsing-Yi; Hsu, Chih-Cheng.
+Institution
+ Chuang, Shu-Chun. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan. Electronic address: scchuang@nhri.org.tw.
+ Wu, I-Chien. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
+ Hsiung, Chao Agnes. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
+ Chan, Huei-Ting. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
+ Cheng, Chiu-Wen. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
+ Chen, Hui-Ling. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
+ Chiu, Yen-Feng. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
+ Lee, Marion M. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States.
+ Chang, Hsing-Yi. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan; Center for Geriatrics and Welfare Research, National Health Research Institutes, Yunlin, Taiwan.
+ Hsu, Chih-Cheng. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan; Center for Geriatrics and Welfare Research, National Health Research Institutes, Yunlin, Taiwan.
+MeSH Subject Headings
+ Male
+ Humans
+ Adult
+ Female
+ *Insulin
+ Cholesterol, HDL
+ Longitudinal Studies
+ *Obesity, Abdominal
+ Taiwan
+ Cross-Sectional Studies
+ Obesity
+ Insulin, Regular, Human
+ Biomarkers
+ Glucose
+ Triglycerides
+Keyword Heading
+ aging
+ dietary inflammatory pattern
+ glucose homeostasis
+ lipids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Dietary patterns related to inflammation have become a focus of disease prevention but the patterns may vary among populations.
+
+ OBJECTIVES: The study was conducted to determine Taiwanese dietary inflammatory patterns and evaluate their associations with biomarkers of lipid and glucose.
+
+ METHODS: Data were taken from 5664 community-dwelling individuals aged >=55 y recruited in 2009-2013 in the Healthy Aging Longitudinal Study in Taiwan (HALST). Dietary data were obtained from an FFQ. An empirical dietary inflammatory pattern (EDIP) was derived from reduced rank regression models that explained the serum high-sensitivity CRP, plasma IL-6, and TNF receptor 1. Cross-sectional associations between dietary scores and biomarkers of total cholesterol (TC); HDL cholesterol; LDL cholesterol; TG; and ratios of TG/HDL cholesterol, TG/TC, fasting glucose, insulin, and HbA1c were analyzed via multiple linear regression and adjusted for major confounders. The false-discovery rate (FDR)-adjusted P < 0.05 was considered statistically significant. Abdominal obesity was defined as a waist circumference of >=90 cm for men and >=80 cm for women.
+
+ RESULTS: Higher EDIP-HALST scores were associated with higher TG (per score increment: 1.62%, 95% CI: 0.58%, 2.76%; PFDR = 0.01), TG/HDL cholesterol (2.01%, 95% CI: 0.67%, 3.37%; PFDR = 0.01), and TG/TC (1.42%, 95% CI: 0.41%, 2.43%; PFDR = 0.01) and nonlinearly associated with insulin, with those in the middle tertile had the highest serum insulin concentrations (means: 5.12 muIU/mL, 95% CI: 4.78, 5.78; PFDR = 0.04) in men, but not in women. No heterogeneity was detected between sexes. The associations with TG (1.23%, 95% CI: 0.19, 2.23%; Ptrend = 0.02), TG/HDL cholesterol (1.62%, 95% CI: 0.30%, 2.96%; Ptrend = 0.02), and TG/TC (1.11%, 95% CI: 0.11%, 2.13%; Ptrend = 0.03) were stronger in participants with abdominal obesity, but were borderline associated in participants with normal abdominal circumferences (all Ptrend = 0.05).
+
+ CONCLUSIONS: Inflammatory diets, as measured via EDIP-HALST, are associated with serum TG concentration, particularly in participants with abdominal obesity. These findings may suggest that developing disease prevention strategies using dietary inflammatory patterns may be different by populations. J Nutr 20xx;x:xx. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Insulin). 0 (Cholesterol, HDL). 0 (Insulin, Regular, Human). 0 (Biomarkers). IY9XDZ35W2 (Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.tjnut.2023.04.015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chuang&issn=0022-3166&title=Journal+of+Nutrition&atitle=Dietary+Inflammatory+Patterns+Are+Associated+With+Serum+TGs+and+Insulin+in+Adults%3A+A+Community-Based+Study+in+Taiwan.&volume=153&issue=6&spage=1783&epage=1792&date=2023&doi=10.1016%2Fj.tjnut.2023.04.015&pmid=37084871&sid=OVID:medline
+
+<267>
+Unique Identifier
+ 37071373
+Title
+ Expression of ICAM-1 and E-selectin in different metabolic obesity phenotypes: discrepancy for endothelial dysfunction.
+Source
+ Journal of Endocrinological Investigation. 46(11):2379-2389, 2023 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu M; Wang P; Xie P; Xu X; He L; Chen X; Zhang S; Lin Y; Huang Y; Xia W; Wang L; Liao X; Guo Y; Zhuang X
+Author NameID
+ Liu, M; ORCID: http://orcid.org/0000-0001-6021-4447
+Authors Full Name
+ Liu, M; Wang, P; Xie, P; Xu, X; He, L; Chen, X; Zhang, S; Lin, Y; Huang, Y; Xia, W; Wang, L; Liao, X; Guo, Y; Zhuang, X.
+Institution
+ Liu, M. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Liu, M. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Wang, P. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Wang, P. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Xie, P. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Xie, P. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Xu, X. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Xu, X. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ He, L. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ He, L. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Chen, X. The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+ Zhang, S. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Zhang, S. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Lin, Y. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Lin, Y. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Huang, Y. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Huang, Y. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Xia, W. Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
+ Wang, L. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Wang, L. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Liao, X. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China.
+ Liao, X. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.
+ Guo, Y. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China. guoy33@mail2.sysu.edu.cn.
+ Guo, Y. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China. guoy33@mail2.sysu.edu.cn.
+ Zhuang, X. Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd., Guangzhou, 510080, China. zhuangxd3@mail.sysu.edu.cn.
+ Zhuang, X. NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China. zhuangxd3@mail.sysu.edu.cn.
+MeSH Subject Headings
+ Humans
+ Intercellular Adhesion Molecule-1/ge [Genetics]
+ E-Selectin/ge [Genetics]
+ Obesity/co [Complications]
+ Phenotype
+ Biomarkers
+ *Vascular Diseases
+ *Metabolic Syndrome
+ Risk Factors
+ Body Mass Index
+Keyword Heading
+ E-selectin
+ Endothelial dysfunction
+ ICAM-1
+ Metabolic disorders
+ Metabolic obesity phenotypes
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Endothelial dysfunction, the earliest vascular alteration, is a consequence of metabolic disorders associated with obesity. However, it is still unclear whether a proportion of obese individuals without metabolic alterations associated with obesity, defined as "metabolically healthy obesity (MHO)", exhibit better endothelial function. We therefore aimed to investigate the association of different metabolic obesity phenotypes with endothelial dysfunction.
+
+ METHODS: The obese participants without clinical cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis) were allocated to the different metabolic obesity phenotypes based on their metabolic status, including MHO and metabolically unhealthy obesity (MUO). Associations of metabolic obesity phenotypes with the biomarkers of endothelial dysfunction, including soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin), were evaluated using multiple linear regression models.
+
+ RESULTS: Plasma levels of sICAM-1 and sE-selectin were respectively measured in 2371 and 968 participants. Compared to the non-obese participants, those with MUO were associated with higher concentrations of sICAM-1 (beta 22.04, 95% CI 14.33-29.75, P < 0.001) and sE-selectin (beta 9.87, 95% CI 6.00-13.75, P < 0.001) after adjusting for confounders. However, no differences were found for the concentrations of sICAM-1 (beta 0.70, 95% CI - 8.91 to 10.32, P = 0.886) and sE-selectin (beta 3.69, 95% CI - 1.13 to 8.51, P = 0.133) in the participants with MHO compared to the non-obese participants.
+
+ CONCLUSIONS: Individuals with MUO were associated with elevated biomarkers of endothelial dysfunction, but the association with endothelial dysfunction was not found in those with MHO, indicating that the individuals with MHO might exhibit better endothelial function. Copyright © 2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).
+Registry Number/Name of Substance
+ 126547-89-5 (Intercellular Adhesion Molecule-1). 0 (E-Selectin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs40618-023-02094-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Expression+of+ICAM-1+and+E-selectin+in+different+metabolic+obesity+phenotypes%3A+discrepancy+for+endothelial+dysfunction.&volume=46&issue=11&spage=2379&epage=2389&date=2023&doi=10.1007%2Fs40618-023-02094-4&pmid=37071373&sid=OVID:medline
+
+<268>
+Unique Identifier
+ 37066906
+Title
+ Plasma Amyloid-beta Homeostasis Is Associated with Body Mass Index and Weight Loss in People with Overweight and Obesity.
+Source
+ Journal of Alzheimer's Disease. 93(2):653-664, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Brook ES; D'Alonzo ZJ; Lam V; Chan DC; Dhaliwal SS; Watts GF; Mamo JCL; Takechi R
+Authors Full Name
+ Brook, Emily S; D'Alonzo, Zachary J; Lam, Virginie; Chan, Dick C; Dhaliwal, Satvinder S; Watts, Geraldb F; Mamo, John C L; Takechi, Ryusuke.
+Institution
+ Brook, Emily S. Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ Brook, Emily S. Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ D'Alonzo, Zachary J. Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ D'Alonzo, Zachary J. Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ Lam, Virginie. Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ Lam, Virginie. School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ Chan, Dick C. Medical School, University of Western Australia, Perth, Australia.
+ Dhaliwal, Satvinder S. Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ Dhaliwal, Satvinder S. Duke-NUS Medical School, National University of Singapore, Singapore.
+ Dhaliwal, Satvinder S. Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia.
+ Dhaliwal, Satvinder S. Singapore University of Social Sciences, Singapore.
+ Watts, Geraldb F. Medical School, University of Western Australia, Perth, Australia.
+ Watts, Geraldb F. Cardiometabolic Service, Department of Cardiology and Internal Medicine, Royal Perth Hospital, Perth, Australia.
+ Mamo, John C L. Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ Mamo, John C L. School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ Mamo, John C L. Perron Institute of Neurological and Translational Sciences, Nedlands, Australia.
+ Takechi, Ryusuke. Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+ Takechi, Ryusuke. School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, Australia.
+MeSH Subject Headings
+ Humans
+ Alzheimer Disease
+ Amyloid beta-Peptides/bl [Blood]
+ *Amyloid beta-Peptides
+ Biomarkers
+ Body Mass Index
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Overweight/bl [Blood]
+ Overweight/co [Complications]
+ *Overweight
+ Peptide Fragments
+Keyword Heading
+ Alzheimer's disease
+ amyloid-beta
+ body mass index
+ obesity
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is linked to a higher incidence of Alzheimer's disease (AD). Studies show that plasma amyloid-beta (Abeta) dyshomeostasis, particularly low 42/40 ratio indicates a heightened risk for developing AD. However, the relationship between body mass index (BMI) and circulating plasma Abeta has not been extensively studied.
+
+ OBJECTIVE: We hypothesized that people with a high BMI have altered plasma Abeta homeostasis compared with people with a lower BMI. We also tested whether reducing BMI by calorie-restriction could normalize plasma concentrations of Abeta.
+
+ METHODS: Plasma concentrations of Abeta40, Abeta42, and Abeta42/40 ratio were measured in 106 participants with BMIs classified as lean, overweight, or obese. From this cohort, twelve participants with overweight or obese BMIs entered a 12-week calorie-restriction weight loss program. We then tested whether decreasing BMI affected plasma Abeta concentrations.
+
+ RESULTS: Plasma Abeta42/40 ratio was 17.54% lower in participants with an obese BMI compared to lean participants (p < 0.0001), and 11.76% lower compared to participants with an overweight BMI (p < 0.0001). The weight loss regimen decreased BMI by an average of 4.02% (p = 0.0005) and was associated with a 6.5% decrease in plasma Abeta40 (p = 0.0425). However, weight loss showed negligible correlations with plasma Abeta40, Abeta42, and Abeta42/40 ratio.
+
+ CONCLUSION: Obesity is associated with aberrant plasma Abeta homeostasis which may be associated with an increased risk for AD. Weight loss appears to lower Abeta40, but large-scale longitudinal studies in addition to molecular studies are required to elucidate the underlying mechanisms of how obesity and weight loss influence plasma Abeta homeostasis.
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Peptides). 0 (Biomarkers). 0 (Peptide Fragments).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3233%2fJAD-220529
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Brook&issn=1387-2877&title=Journal+of+Alzheimer%27s+Disease&atitle=Plasma+Amyloid-beta+Homeostasis+Is+Associated+with+Body+Mass+Index+and+Weight+Loss+in+People+with+Overweight+and+Obesity.&volume=93&issue=2&spage=653&epage=664&date=2023&doi=10.3233%2FJAD-220529&pmid=37066906&sid=OVID:medline
+
+<269>
+Unique Identifier
+ 37059208
+Title
+ The association between internal polycyclic aromatic hydrocarbons exposure and risk of Obesity-A systematic review with meta-analysis.
+Source
+ Chemosphere. 329:138669, 2023 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu C; Liu Q; Song S; Li W; Feng Y; Cong X; Ji Y; Li P
+Authors Full Name
+ Liu, Chunyu; Liu, Qisijing; Song, Shanjun; Li, Weixia; Feng, Yuanyuan; Cong, Xiangru; Ji, Yaqin; Li, Penghui.
+Institution
+ Liu, Chunyu. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China.
+ Liu, Qisijing. Research Institute of Public Health, Nankai University, Tianjin, 300071, China.
+ Song, Shanjun. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China; Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, 300384, China; National Institute of Metrology, Beijing, 100029, China. Electronic address: songsj@nim.ac.cn.
+ Li, Weixia. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China.
+ Feng, Yuanyuan. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China.
+ Cong, Xiangru. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China.
+ Ji, Yaqin. College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, China.
+ Li, Penghui. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China; Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, 300384, China. Electronic address: lipenghui406@163.com.
+MeSH Subject Headings
+ Child
+ Humans
+ Female
+ *Polycyclic Aromatic Hydrocarbons
+ Cross-Sectional Studies
+ Obesity/ci [Chemically Induced]
+ Obesity/ep [Epidemiology]
+ Risk Factors
+ Biomarkers
+Keyword Heading
+ Meta-analysis
+ Obesity
+ Polycyclic aromatic hydrocarbons
+ Systematic review
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Exposure to polycyclic aromatic hydrocarbons (PAHs) is emerging as a risk factor for obesity, but with conflicting findings. The aim of this systematic review is to investigate and summarize the current evidence towards the associations between PAHs exposure and risk of obesity. We conducted a systematic search of online databases, including PubMed, Embase, Cochrane Library, and Web of Science up to April 28, 2022. Eight cross-sectional studies with data from 68,454 participants were included. The present study illustrated that there was a significant positive association between naphthalene (NAP), phenanthrene (PHEN), and total OH-PAH metabolites and risk of obesity, the pooled OR (95% CI) was estimated at 1.43 (1.07, 1.90), 1.54 (1.18, 2.02), and 2.29 (1.32, 3.99), respectively. However, there was no significant association between fluorene (FLUO) and1-hydroxypyrene (1-OHP) metabolite and risk of obesity. Subgroup analyses showed that associations between PAHs exposure and risk of obesity were more apparent in children, female, smokers and developing regions. Copyright © 2023 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Polycyclic Aromatic Hydrocarbons). 0 (Biomarkers).
+Publication Type
+ Meta-Analysis. Systematic Review. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.chemosphere.2023.138669
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=0045-6535&title=Chemosphere&atitle=The+association+between+internal+polycyclic+aromatic+hydrocarbons+exposure+and+risk+of+Obesity-A+systematic+review+with+meta-analysis.&volume=329&issue=&spage=138669&epage=&date=2023&doi=10.1016%2Fj.chemosphere.2023.138669&pmid=37059208&sid=OVID:medline
+
+<270>
+Unique Identifier
+ 37047082
+Title
+ Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development. [Review]
+Source
+ International Journal of Molecular Sciences. 24(7), 2023 Mar 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Warmink K; Vinod P; Korthagen NM; Weinans H; Rios JL
+Author NameID
+ Warmink, Kelly; ORCID: https://orcid.org/0000-0003-4131-675X
+ Rios, Jaqueline L; ORCID: https://orcid.org/0000-0002-3679-2869
+Authors Full Name
+ Warmink, Kelly; Vinod, Prateeksha; Korthagen, Nicoline M; Weinans, Harrie; Rios, Jaqueline L.
+Institution
+ Warmink, Kelly. Department of Orthopedics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
+ Vinod, Prateeksha. Department of Orthopedics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
+ Korthagen, Nicoline M. Department of Orthopedics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
+ Korthagen, Nicoline M. Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
+ Weinans, Harrie. Department of Orthopedics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
+ Weinans, Harrie. Department of Biomechanical Engineering, TU Delft, 2628 CD Delft, The Netherlands.
+ Rios, Jaqueline L. Department of Orthopedics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
+MeSH Subject Headings
+ Humans
+ Osteoarthritis/di [Diagnosis]
+ Osteoarthritis/et [Etiology]
+ Osteoarthritis/dt [Drug Therapy]
+ *Osteoarthritis
+ Inflammation/me [Metabolism]
+ Macrophages/me [Metabolism]
+ Obesity/me [Metabolism]
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ inflammation
+ macrophages
+ metabolic syndrome
+ obesity
+ osteoarthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear disease, and the immune system might have a role in its initiation and progression. Obesity, which is directly associated with an increased incidence of OA, alters adipokine release, increases pro-inflammatory macrophage activity, and affects joint immune regulation. Studying inflammatory macrophage expression and strategies to inhibit inflammatory macrophage phenotype polarization might provide insights into disease pathogenesis and therapeutic applications. In pre-clinical studies, the detection of OA in its initial stages was shown to be possible using imaging techniques such as SPECT-CT, and advances are made to detect OA through blood-based biomarker analysis. In this review, obesity-induced osteoarthritis and its mechanisms in inducing joint degeneration are summarized, along with an analysis of the current developments in patient imaging and biomarker use for diagnostic and therapeutic strategies.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fijms24076112
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Warmink&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Macrophage-Driven+Inflammation+in+Metabolic+Osteoarthritis%3A+Implications+for+Biomarker+and+Therapy+Development.&volume=24&issue=7&spage=6112&epage=&date=2023&doi=10.3390%2Fijms24076112&pmid=37047082&sid=OVID:medline
+
+<271>
+Unique Identifier
+ 37039941
+Title
+ Association Between Parameters of Cortisol Metabolism, Biomarkers of Minerals (Zinc, Selenium, and Magnesium), and Insulin Resistance and Oxidative Stress in Women with Obesity.
+Source
+ Biological Trace Element Research. 201(12):5677-5691, 2023 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Morais JBS; Cruz KJC; de Oliveira ARS; Cardoso BEP; da Silva Dias TM; de Sousa Melo SR; Dos Santos LR; Severo JS; de Freitas ST; Henriques GS; da Silva MTB; Oliveira FE; do Nascimento Marreiro D
+Author NameID
+ Morais, Jennifer Beatriz Silva; ORCID: http://orcid.org/0000-0002-9055-7851
+ Cruz, Kyria Jayanne Climaco; ORCID: http://orcid.org/0000-0002-4489-702X
+ de Oliveira, Ana Raquel Soares; ORCID: http://orcid.org/0000-0001-5383-0137
+ Cardoso, Bruna Emanuele Pereira; ORCID: http://orcid.org/0000-0002-3863-1276
+ da Silva Dias, Thaline Milany; ORCID: http://orcid.org/0000-0003-1734-4312
+ de Sousa Melo, Stefany Rodrigues; ORCID: http://orcid.org/0000-0001-5308-3522
+ Dos Santos, Loanne Rocha; ORCID: https://orcid.org/0000-0002-5418-6715
+ Severo, Juliana Soares; ORCID: https://orcid.org/0000-0002-1771-7871
+ de Freitas, Suelem Torres; ORCID: https://orcid.org/0000-0002-2146-2840
+ Henriques, Gilberto Simeone; ORCID: https://orcid.org/0000-0002-9110-5427
+ da Silva, Moises Tolentino Bento; ORCID: https://orcid.org/0000-0002-6178-9880
+ Oliveira, Francisco Erasmo; ORCID: https://orcid.org/0000-0001-9941-3419
+ do Nascimento Marreiro, Dilina; ORCID: https://orcid.org/0000-0002-7550-1403
+Authors Full Name
+ Morais, Jennifer Beatriz Silva; Cruz, Kyria Jayanne Climaco; de Oliveira, Ana Raquel Soares; Cardoso, Bruna Emanuele Pereira; da Silva Dias, Thaline Milany; de Sousa Melo, Stefany Rodrigues; Dos Santos, Loanne Rocha; Severo, Juliana Soares; de Freitas, Suelem Torres; Henriques, Gilberto Simeone; da Silva, Moises Tolentino Bento; Oliveira, Francisco Erasmo; do Nascimento Marreiro, Dilina.
+Institution
+ Morais, Jennifer Beatriz Silva. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Cruz, Kyria Jayanne Climaco. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ de Oliveira, Ana Raquel Soares. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Cardoso, Bruna Emanuele Pereira. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ da Silva Dias, Thaline Milany. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ de Sousa Melo, Stefany Rodrigues. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Dos Santos, Loanne Rocha. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ Severo, Juliana Soares. Department of Nutrition, Federal University of Piaui, Teresina, Brazil.
+ de Freitas, Suelem Torres. Federal University of Para, Belem, Brazil.
+ Henriques, Gilberto Simeone. School of Nursing, Federal University, Minas Gerais, Belo Horizonte, Brazil.
+ da Silva, Moises Tolentino Bento. Institute of Biomedical Sciences Abel Salazar, Center for Drug Discovery and Innovative Medicines, Laboratory of Physiology, Department of Immuno-Physiology and Pharmacology, University of Porto, Porto, Portugal.
+ Oliveira, Francisco Erasmo. Clinical Laboratory, Teresina, Piaui, Brazil.
+ do Nascimento Marreiro, Dilina. Department of Nutrition, Federal University of Piaui, Teresina, Brazil. dilina.marreiro@ufpi.edu.br.
+MeSH Subject Headings
+ Female
+ Humans
+ Biomarkers
+ Cross-Sectional Studies
+ Hydrocortisone/me [Metabolism]
+ *Insulin Resistance
+ Magnesium/me [Metabolism]
+ Obesity/me [Metabolism]
+ *Obesity
+ Oxidative Stress
+ Selenium/me [Metabolism]
+ Superoxide Dismutase/me [Metabolism]
+ Zinc/me [Metabolism]
+ Trace Elements/me [Metabolism]
+ *Trace Elements
+Keyword Heading
+ Cortisol
+ Insulin resistance
+ Magnesium
+ Obesity
+ Oxidative stress
+ Selenium
+ Zinc
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This is a cross-sectional study with women divided into a group of those with obesity (n = 80) and a control group (n = 94). Statistical analysis was conducted using the SPSS program. There were high values of GPx and TBARS and reduced values of SOD in women with obesity compared to the control group. Obese women showed increased concentrations of cortisol in serum and urine as well as hypozincemia, hyposelenemia, and hypomagnesemia and increased urinary excretion of these minerals. There was a negative correlation between the cortisol/cortisone ratio and erythrocyte zinc and selenium concentrations and a significant positive correlation between GPx and SOD activity and erythrocyte and plasma concentrations of zinc and selenium. The results of the study suggest the influence of adiposity on the increase in cortisol concentrations and the role of this hormone in the compartmentalization of the minerals zinc, selenium, and magnesium. However, the association study does not allow identifying the impact of such action on the antioxidant defense system and insulin sensitivity. Copyright © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). WI4X0X7BPJ (Hydrocortisone). I38ZP9992A (Magnesium). H6241UJ22B (Selenium). EC 1-15-1-1 (Superoxide Dismutase). J41CSQ7QDS (Zinc). 0 (Trace Elements).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs12011-023-03639-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Morais&issn=0163-4984&title=Biological+Trace+Element+Research&atitle=Association+Between+Parameters+of+Cortisol+Metabolism%2C+Biomarkers+of+Minerals+%28Zinc%2C+Selenium%2C+and+Magnesium%29%2C+and+Insulin+Resistance+and+Oxidative+Stress+in+Women+with+Obesity.&volume=201&issue=12&spage=5677&epage=5691&date=2023&doi=10.1007%2Fs12011-023-03639-7&pmid=37039941&sid=OVID:medline
+
+<272>
+Unique Identifier
+ 37024861
+Title
+ Biomarkers as predictors of mortality in critically ill obese patients with COVID-19 at high altitude.
+Source
+ BMC Pulmonary Medicine. 23(1):112, 2023 Apr 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Velez-Paez JL; Aguayo-Moscoso SX; Castro-Bustamante C; Montalvo-Villagomez M; Jara-Gonzalez F; Baldeon-Rojas L; Zubieta-DeUrioste N; Battaglini D; Zubieta-Calleja GR
+Authors Full Name
+ Velez-Paez, Jorge Luis; Aguayo-Moscoso, Santiago Xavier; Castro-Bustamante, Christian; Montalvo-Villagomez, Mario; Jara-Gonzalez, Fernando; Baldeon-Rojas, Lucy; Zubieta-DeUrioste, Natalia; Battaglini, Denise; Zubieta-Calleja, Gustavo R.
+Institution
+ Velez-Paez, Jorge Luis. Centro de Investigacion Clinica, Hospital Pablo Arturo Suarez, Unidad de Terapia Intensiva, Quito, Ecuador. jorgeluisvelez13@hotmail.com.
+ Velez-Paez, Jorge Luis. Facultad de Ciencias Medicas, Universidad Central del Ecuador, Quito, Ecuador. jorgeluisvelez13@hotmail.com.
+ Aguayo-Moscoso, Santiago Xavier. Centro de Investigacion Clinica, Hospital Pablo Arturo Suarez, Unidad de Terapia Intensiva, Quito, Ecuador.
+ Castro-Bustamante, Christian. Centro de Investigacion Clinica, Hospital Pablo Arturo Suarez, Unidad de Terapia Intensiva, Quito, Ecuador.
+ Montalvo-Villagomez, Mario. Centro de Investigacion Clinica, Hospital Pablo Arturo Suarez, Unidad de Terapia Intensiva, Quito, Ecuador.
+ Jara-Gonzalez, Fernando. Centro de Investigacion Clinica, Hospital Pablo Arturo Suarez, Unidad de Terapia Intensiva, Quito, Ecuador.
+ Baldeon-Rojas, Lucy. Facultad de Ciencias Medicas, Universidad Central del Ecuador, Quito, Ecuador.
+ Baldeon-Rojas, Lucy. Instituto de Investigacion en Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
+ Zubieta-DeUrioste, Natalia. High Altitude Pulmonary & Pathology Institute (HAPPI-IPPA), La Paz, Bolivia.
+ Battaglini, Denise. IRCCS Ospedale Policlinico San Martino, Genova, Italy. battaglini.denise@gmail.com.
+ Zubieta-Calleja, Gustavo R. High Altitude Pulmonary & Pathology Institute (HAPPI-IPPA), La Paz, Bolivia.
+MeSH Subject Headings
+ Humans
+ Overweight/co [Complications]
+ *Overweight
+ Retrospective Studies
+ Critical Illness
+ Altitude
+ COVID-19/co [Complications]
+ *COVID-19
+ Obesity/co [Complications]
+ Body Mass Index
+ Biomarkers
+ Intensive Care Units
+Keyword Heading
+ Altitude
+ COVID-19
+ Coronavirus disease
+ Obese
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a common chronic comorbidity of patients with COVID-19, that has been associated with disease severity and mortality. COVID-19 at high altitude seems to be associated with increased rate of ICU discharge and hospital survival than at sea-level, despite higher immune levels and inflammation. The primary aim of this study was to investigate the survival rate of critically ill obese patients with COVID-19 at altitude in comparison with overweight and normal patients. Secondary aims were to assess the predictive factors for mortality, characteristics of mechanical ventilation setting, extubation rates, and analytical parameters.
+
+ METHODS: This is a retrospective cohort study in critically ill patients with COVID-19 admitted to a hospital in Quito-Ecuador (2,850 m) from Apr 1, 2020, to Nov 1, 2021. Patients were cathegorized as normal weight, overweight, and obese, according to body mass index [BMI]).
+
+ RESULTS: In the final analysis 340 patients were included, of whom 154 (45%) were obese, of these 35 (22.7%) were hypertensive and 25 (16.2%) were diabetic. Mortality in obese patients (31%) was lower than in the normal weight (48%) and overweight (40%) groups, but not statistically significant (p = 0.076). At multivariable analysis, in the overall population, older age (> 50 years) was independent risk factor for mortality (B = 0.93, Wald = 14.94, OR = 2.54 95%CI = 1.58-4.07, p < 0.001). Ferritin and the neutrophil/lymphocyte ratio were independent predictors of mortality in obese patients. Overweight and obese patients required more positive and-expiratory pressure compared to normal-weight patients. In obese patients, plateau pressure and mechanical power were significantly higher, whereas extubation failure was lower as compared to overweight and normal weight.
+
+ CONCLUSIONS: This preliminary study suggests that BMI was not associated with mortality in critically ill patients at high altitude. Age was associated with an increase in mortality independent of the BMI. Biomarkers such as ferritin and neutrophils/lymphocytes ratio were independent predictors of mortality in obese patients with COVID-19 at high altitude. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1186%2fs12890-023-02399-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Velez-Paez&issn=1471-2466&title=BMC+Pulmonary+Medicine&atitle=Biomarkers+as+predictors+of+mortality+in+critically+ill+obese+patients+with+COVID-19+at+high+altitude.&volume=23&issue=1&spage=112&epage=&date=2023&doi=10.1186%2Fs12890-023-02399-3&pmid=37024861&sid=OVID:medline
+
+<273>
+Unique Identifier
+ 37019912
+Title
+ KLB and NOX4 expression levels as potential blood-based transcriptional biomarkers of physical activity in children.
+Source
+ Scientific Reports. 13(1):5563, 2023 04 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Galmes S; Ruperez AI; Sanchez J; Moreno LA; Foraita R; Hebestreit A; Molnar D; Palou A; Pico C
+Authors Full Name
+ Galmes, Sebastia; Ruperez, Azahara I; Sanchez, Juana; Moreno, Luis A; Foraita, Ronja; Hebestreit, Antje; Molnar, Denes; Palou, Andreu; Pico, Catalina.
+Institution
+ Galmes, Sebastia. Laboratory of Molecular Biology, Nutrition and Biotechnology (Group of Nutrigenomics, Biomarkers and Risk Evaluation - NuBE), University of the Balearic Islands, Cra. Valldemossa Km 7.5, 07122, Palma, Spain.
+ Galmes, Sebastia. Health Research Institute of the Balearic Islands (IdISBa), 07120, Palma, Spain.
+ Galmes, Sebastia. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, 28029, Madrid, Spain.
+ Ruperez, Azahara I. GENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, University of Zaragoza, 50009, Zaragoza, Spain.
+ Ruperez, Azahara I. Instituto Agroalimentario de Aragon (IA2) and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain.
+ Sanchez, Juana. Laboratory of Molecular Biology, Nutrition and Biotechnology (Group of Nutrigenomics, Biomarkers and Risk Evaluation - NuBE), University of the Balearic Islands, Cra. Valldemossa Km 7.5, 07122, Palma, Spain.
+ Sanchez, Juana. Health Research Institute of the Balearic Islands (IdISBa), 07120, Palma, Spain.
+ Sanchez, Juana. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, 28029, Madrid, Spain.
+ Moreno, Luis A. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, 28029, Madrid, Spain.
+ Moreno, Luis A. GENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, University of Zaragoza, 50009, Zaragoza, Spain.
+ Moreno, Luis A. Instituto Agroalimentario de Aragon (IA2) and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain.
+ Foraita, Ronja. Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359, Bremen, Germany.
+ Hebestreit, Antje. Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359, Bremen, Germany.
+ Molnar, Denes. Medical School and National Laboratories of Human Reproduction, University of Pecs, 7624, Pecs, Hungary.
+ Palou, Andreu. Laboratory of Molecular Biology, Nutrition and Biotechnology (Group of Nutrigenomics, Biomarkers and Risk Evaluation - NuBE), University of the Balearic Islands, Cra. Valldemossa Km 7.5, 07122, Palma, Spain. andreu.palou@uib.cat.
+ Palou, Andreu. Health Research Institute of the Balearic Islands (IdISBa), 07120, Palma, Spain. andreu.palou@uib.cat.
+ Palou, Andreu. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, 28029, Madrid, Spain. andreu.palou@uib.cat.
+ Pico, Catalina. Laboratory of Molecular Biology, Nutrition and Biotechnology (Group of Nutrigenomics, Biomarkers and Risk Evaluation - NuBE), University of the Balearic Islands, Cra. Valldemossa Km 7.5, 07122, Palma, Spain.
+ Pico, Catalina. Health Research Institute of the Balearic Islands (IdISBa), 07120, Palma, Spain.
+ Pico, Catalina. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, 28029, Madrid, Spain.
+MeSH Subject Headings
+ Humans
+ Child
+ Exercise/ph [Physiology]
+ *Exercise
+ Obesity
+ Biomarkers
+ Sedentary Behavior
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ NADPH Oxidase 4
+ Klotho Proteins
+Abstract
+ Insufficient physical activity (PA) in children is considered one of the major contributors to obesity and cardiometabolic complications later in life. Although regular exercise may contribute to disease prevention and health promotion, reliable early biomarkers are required to objectively discern people performing low PA from those who exercise enough. Here, we aimed to identify potential transcript-based biomarkers through the analysis of a whole-genome microarray in peripheral blood cells (PBC) from physically less active (n = 10) comparing with more active (n = 10) children. A set of genes differentially expressed (p < 0.01, Limma test) in less physically active children were identified, including the down-regulation of genes related to cardiometabolic benefits and improved skeletal function (KLB, NOX4, and SYPL2), and the up-regulation of genes whose elevated expression levels are associated with metabolic complications (IRX5, UBD, and MGP). The analysis of the enriched pathways significantly affected by PA levels were those associated with protein catabolism, skeletal morphogenesis, and wound healing, among others, which may suggest a differential impact of low PA on these processes. Microarray analysis comparing children according to their usual PA has revealed potential PBC transcript-based biomarkers that may be useful in early discerning children expending high sedentary time and its associated negative consequences. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 1-6-3 (NOX4 protein, human). EC 1-6-3 (NADPH Oxidase 4). 0 (KLB protein, human). EC 3-2-1-31 (Klotho Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1038%2fs41598-023-31537-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Galmes&issn=2045-2322&title=Scientific+Reports&atitle=KLB+and+NOX4+expression+levels+as+potential+blood-based+transcriptional+biomarkers+of+physical+activity+in+children.&volume=13&issue=1&spage=5563&epage=&date=2023&doi=10.1038%2Fs41598-023-31537-4&pmid=37019912&sid=OVID:medline
+
+<274>
+Unique Identifier
+ 37019591
+Title
+ Role of DNA methylation in diabetes and obesity.
+Source
+ Progress in Molecular Biology & Translational Science. 197:153-170, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chu DT; Bui NL; Vu Thi H; Nguyen Thi YV
+Authors Full Name
+ Chu, Dinh-Toi; Bui, Nhat-Le; Vu Thi, Hue; Nguyen Thi, Yen-Vy.
+Institution
+ Chu, Dinh-Toi. Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam. Electronic address: toicd@vnu.edu.vn.
+ Bui, Nhat-Le. Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam.
+ Vu Thi, Hue. Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam.
+ Nguyen Thi, Yen-Vy. Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam.
+MeSH Subject Headings
+ Humans
+ *DNA Methylation
+ Epigenesis, Genetic
+ *Diabetes Mellitus
+ Obesity
+ Biomarkers
+Keyword Heading
+ DNA methylation
+ Diabetes
+ Epigenetics
+ Metabolism
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Due to the fact that the upward trend of several metabolic disorders such as diabetes and obesity, in individuals especially monozygotic twins, who are under the same effects from the environment, are not similar, the role of epigenetic elements like DNA methylation needs taking into account. In this chapter, emerging scientific evidence supporting the strong relationship between changes in DNA methylation and those diseases' development was summarized. Changing in the expression level of diabetes/obesity-related genes through being silenced by methylation can be the underlying mechanism of this phenomenon. Genes with abnormal methylation status are potential biomarkers for early prediction and diagnosis. Moreover, methylation-based molecular targets should be investigated as a new treatment for both T2D and obesity. Copyright © 2023 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fbs.pmbts.2023.01.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chu&issn=1877-1173&title=Progress+in+Molecular+Biology+%26+Translational+Science&atitle=Role+of+DNA+methylation+in+diabetes+and+obesity.&volume=197&issue=&spage=153&epage=170&date=2023&doi=10.1016%2Fbs.pmbts.2023.01.008&pmid=37019591&sid=OVID:medline
+
+<275>
+Unique Identifier
+ 37012425
+Title
+ Prenatal oxidative stress and rapid infant weight gain.
+Source
+ International Journal of Obesity. 47(7):583-589, 2023 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Duh-Leong C; Ghassabian A; Kannan K; Gross RS; Ortiz R; Gaylord A; Afanasyeva Y; Lakuleswaran M; Spadacini L; Trasande L
+Author NameID
+ Duh-Leong, Carol; ORCID: https://orcid.org/0000-0001-5648-580X
+ Ghassabian, Akhgar; ORCID: https://orcid.org/0000-0001-9551-4706
+ Ortiz, Robin; ORCID: https://orcid.org/0000-0002-0957-5850
+ Trasande, Leonardo; ORCID: https://orcid.org/0000-0002-1928-597X
+Authors Full Name
+ Duh-Leong, Carol; Ghassabian, Akhgar; Kannan, Kurunthachalam; Gross, Rachel S; Ortiz, Robin; Gaylord, Abigail; Afanasyeva, Yelena; Lakuleswaran, Mathusa; Spadacini, Larry; Trasande, Leonardo.
+Institution
+ Duh-Leong, Carol. Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA. carol.duh-leong@nyulangone.org.
+ Ghassabian, Akhgar. Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
+ Ghassabian, Akhgar. Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
+ Kannan, Kurunthachalam. Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
+ Kannan, Kurunthachalam. Department of Environmental Medicine, NYU Grossman School of Medicine, New York, NY, USA.
+ Gross, Rachel S. Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
+ Gross, Rachel S. Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
+ Ortiz, Robin. Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
+ Ortiz, Robin. Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
+ Ortiz, Robin. Institute for Excellence in Health Equity, NYU Langone Health, New York, NY, USA.
+ Gaylord, Abigail. Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.
+ Afanasyeva, Yelena. Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
+ Lakuleswaran, Mathusa. Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
+ Spadacini, Larry. Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
+ Trasande, Leonardo. Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
+ Trasande, Leonardo. Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
+ Trasande, Leonardo. Department of Environmental Medicine, NYU Grossman School of Medicine, New York, NY, USA.
+ Trasande, Leonardo. NYU Wagner Graduate School of Public Service, New York, NY, USA.
+ Trasande, Leonardo. NYU School of Global Public Health, New York, NY, USA.
+MeSH Subject Headings
+ Infant, Newborn
+ Child
+ Pregnancy
+ Female
+ Humans
+ Infant
+ Birth Weight
+ Prospective Studies
+ *Weight Gain
+ *Obesity
+ Oxidative Stress
+ Vitamins
+ Biomarkers
+Abstract
+ BACKGROUND AND OBJECTIVES: Infant weight patterns predict subsequent weight outcomes. Rapid infant weight gain, defined as a >0.67 increase in weight-for-age z-score (WAZ) between two time points in infancy, increases obesity risk. Higher oxidative stress, an imbalance between antioxidants and reactive oxygen species, has been associated with low birthweight and paradoxically also with later obesity. We hypothesized that prenatal oxidative stress may also be associated with rapid infant weight gain, an early weight pattern associated with future obesity.
+
+ METHODS: Within the NYU Children's Health and Environment Study prospective pregnancy cohort, we analyzed associations between prenatal lipid, protein, and DNA urinary oxidative stress biomarkers and infant weight data. Primary outcome was rapid infant weight gain (>0.67 increase in WAZ) between birth and later infancy at the 8 or 12 month visit. Secondary outcomes included: very rapid weight gain (>1.34 increase in WAZ), low (<2500 g) or high (>=4000 g) birthweight, and low (< -1 WAZ) or high (>1 WAZ) 12 month weight.
+
+ RESULTS: Pregnant participants consented to the postnatal study (n = 541); 425 participants had weight data both at birth and in later infancy. In an adjusted binary model, prenatal 8-iso-PGF2alpha, a lipid oxidative stress biomarker, was associated with rapid infant weight gain (aOR 1.44; 95% CI: 1.16, 1.78, p = 0.001). In a multinomial model using <=0.67 change in WAZ as a reference group, 8-iso-PGF2alpha was associated with rapid infant weight gain (defined as >0.67 but <=1.34 WAZ; aOR 1.57, 95% CI: 1.19, 2.05, p = 0.001) and very rapid infant weight gain (defined as >1.34 WAZ; aOR 1.33; 95% CI: 1.02, 1.72, p < 0.05) Secondary analyses detected associations between 8-iso-PGF2alpha and low birthweight outcomes.
+
+ CONCLUSIONS: We found an association between 8-iso-PGF2alpha, a lipid prenatal oxidative stress biomarker, and rapid infant weight gain, expanding our understanding of the developmental origins of obesity and cardiometabolic disease. Copyright © 2023. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Vitamins). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, P.H.S..
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1038%2fs41366-023-01302-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Duh-Leong&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Prenatal+oxidative+stress+and+rapid+infant+weight+gain.&volume=47&issue=7&spage=583&epage=589&date=2023&doi=10.1038%2Fs41366-023-01302-8&pmid=37012425&sid=OVID:medline
+
+<276>
+Unique Identifier
+ 37004309
+Title
+ Body fat and components of sarcopenia relate to inflammation, brain volume, and neurometabolism in older adults.
+Source
+ Neurobiology of Aging. 127:1-11, 2023 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vints WAJ; Kusleikiene S; Sheoran S; Valatkeviciene K; Gleizniene R; Himmelreich U; Paasuke M; Cesnaitiene VJ; Levin O; Verbunt J; Masiulis N
+Authors Full Name
+ Vints, Wouter A J; Kusleikiene, Simona; Sheoran, Samrat; Valatkeviciene, Kristina; Gleizniene, Rymante; Himmelreich, Uwe; Paasuke, Mati; Cesnaitiene, Vida J; Levin, Oron; Verbunt, Jeanine; Masiulis, Nerijus.
+Institution
+ Vints, Wouter A J. Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania; Department of Rehabilitation Medicine Research School CAPHRI, Maastricht University, Maastricht, the Netherlands; Centre of Expertise in Rehabilitation and Audiology, Adelante Zorggroep, Hoensbroek, the Netherlands. Electronic address: w.vints@maastrichtuniversity.nl.
+ Kusleikiene, Simona. Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
+ Sheoran, Samrat. Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
+ Valatkeviciene, Kristina. Department of Radiology, Kauno Klinikos, Lithuanian University of Health Sciences, Kaunas, Lithuania.
+ Gleizniene, Rymante. Department of Radiology, Kauno Klinikos, Lithuanian University of Health Sciences, Kaunas, Lithuania.
+ Himmelreich, Uwe. Biomedical MRI Unit, Department of Imaging and Pathology, Group Biomedical Sciences, Catholic University Leuven, Leuven, Belgium.
+ Paasuke, Mati. Institute of Sport Sciences and Physiotherapy, University of Tartu, Tartu, Estonia.
+ Cesnaitiene, Vida J. Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
+ Levin, Oron. Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania; Movement Control & Neuroplasticity Research Group, Group Biomedical Sciences, Catholic University Leuven, Heverlee, Belgium.
+ Verbunt, Jeanine. Department of Rehabilitation Medicine Research School CAPHRI, Maastricht University, Maastricht, the Netherlands; Centre of Expertise in Rehabilitation and Audiology, Adelante Zorggroep, Hoensbroek, the Netherlands.
+ Masiulis, Nerijus. Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
+MeSH Subject Headings
+ Humans
+ Aged
+ Aged, 80 and over
+ Sarcopenia/dg [Diagnostic Imaging]
+ *Sarcopenia
+ Hand Strength
+ Creatine
+ Kynurenine
+ Brain/dg [Diagnostic Imaging]
+ Brain/pa [Pathology]
+ Adipose Tissue
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Inflammation/pa [Pathology]
+ Biomarkers
+ Encephalitis/pa [Pathology]
+ *Encephalitis
+Keyword Heading
+ Aging
+ Body composition
+ Cognition
+ Neuroinflammation
+ Neurotrophic factor
+ Physical fitness
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and sarcopenia are associated with cognitive impairments at older age. Current research suggests that blood biomarkers may mediate this body-brain crosstalk, altering neurometabolism and brain structure eventually resulting in cognitive performance changes. Seventy-four older adults (60-85 years old) underwent bio-impedance body composition analysis, handgrip strength measurements, 8-Foot Up-and-Go (8UG) test, Montreal Cognitive Assessment (MoCA), blood analysis of interleukin-6 (IL-6), kynurenine, and insulin-like growth factor-1 (IGF-1), as well as brain magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS), estimating neurodegeneration and neuroinflammation. Normal fat% or overweight was associated with larger total gray matter volume compared to underweight or obesity in older adults and obesity was associated with higher N-acetylaspartate/Creatine levels in the sensorimotor and dorsolateral prefrontal cortex. Muscle strength, not muscle mass/physical performance, corresponded to lower kynurenine and higher N-acetylaspartate/Creatine levels in the dorsal posterior cingulate and dorsolateral prefrontal cortex. The inflammatory and neurotrophic blood biomarkers did not significantly mediate these body-brain associations. This study used a multimodal approach to comprehensively assess the proposed mechanism of body-brain crosstalk. Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ MU72812GK0 (Creatine). 343-65-7 (Kynurenine). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.neurobiolaging.2023.02.011
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vints&issn=0197-4580&title=Neurobiology+of+Aging&atitle=Body+fat+and+components+of+sarcopenia+relate+to+inflammation%2C+brain+volume%2C+and+neurometabolism+in+older+adults.&volume=127&issue=&spage=1&epage=11&date=2023&doi=10.1016%2Fj.neurobiolaging.2023.02.011&pmid=37004309&sid=OVID:medline
+
+<277>
+Unique Identifier
+ 37004213
+Title
+ Osteoarthritis, part of life or a curable disease? A bird's-eye view. [Review]
+Source
+ Journal of Internal Medicine. 293(6):681-693, 2023 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Englund M
+Author NameID
+ Englund, Martin; ORCID: https://orcid.org/0000-0003-3320-2437
+Authors Full Name
+ Englund, Martin.
+Institution
+ Englund, Martin. Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Faculty of Medicine, Lund University, Lund, Sweden.
+MeSH Subject Headings
+ Humans
+ Osteoarthritis/di [Diagnosis]
+ Osteoarthritis/dt [Drug Therapy]
+ Osteoarthritis/me [Metabolism]
+ *Osteoarthritis
+ Inflammation/co [Complications]
+ Biomarkers/me [Metabolism]
+ Pain
+ Obesity/co [Complications]
+Keyword Heading
+ epidemiology
+ etiology
+ osteoarthritis
+ pain
+ therapeutics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Osteoarthritis (OA) is a chronic joint disease caused by disruption of joint homeostasis by a variety of systemic and biomechanical factors. The disease is characterized by degradation of cartilage and other joint tissues, and low-grade inflammation which may result in pain, reduced function, and disability. The disease appears to have ancient origins, with findings of OA recognized in fossilized bones from birdlike dinosaurs living some 130 million years ago. Today, the burden of OA in the world's population is steadily increasing due to aging and often rising rates of obesity. Structural findings, indicative of the disease, are also frequent in asymptomatic persons, which make the distinction between disease and normal aging sometimes challenging. OA is frequently associated with comorbidity in the form of obesity, cardiovascular disease, and depressive symptoms. The current management and treatments largely rely on contextual factors, and the actual effects of the intended therapeutic element of today's interventions are minor. The different mechanistic pathways (endotypes) and clinical characteristics (phenotypes) of OA make the development of disease-modifying treatments challenging. Current development of drug candidates, aimed to restore joint homeostasis, is mainly targeting either inhibition of catabolic factors or stimulation of anabolic factors. However, there is yet no breakthrough in stage III clinical trials. Earlier diagnosis, better knowledge of endotypes-for example, by new insights into soluble biomarkers, and compositional imaging-and more careful selection of patients into clinical trials are possible tools to aid development of future therapies. Copyright © 2023 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1111%2fjoim.13634
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Englund&issn=0954-6820&title=Journal+of+Internal+Medicine&atitle=Osteoarthritis%2C+part+of+life+or+a+curable+disease%3F+A+bird%27s-eye+view.&volume=293&issue=6&spage=681&epage=693&date=2023&doi=10.1111%2Fjoim.13634&pmid=37004213&sid=OVID:medline
+
+<278>
+Unique Identifier
+ 36998214
+Title
+ Inverse Associations between Measures of Adiposity and Glycated Albumin in US Adults, NHANES 1999-2004.
+Source
+ The Journal of Applied Laboratory Medicine. 8(4):751-762, 2023 07 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sullivan VK; Wallace AS; Rooney MR; Zhang S; Fang M; Christenson RH; Selvin E
+Author NameID
+ Sullivan, Valerie K; ORCID: https://orcid.org/0000-0002-2321-0188
+ Rooney, Mary R; ORCID: https://orcid.org/0000-0002-5607-4848
+ Zhang, Sui; ORCID: https://orcid.org/0000-0001-8279-6353
+ Selvin, Elizabeth; ORCID: https://orcid.org/0000-0001-6923-7151
+Authors Full Name
+ Sullivan, Valerie K; Wallace, Amelia S; Rooney, Mary R; Zhang, Sui; Fang, Michael; Christenson, Robert H; Selvin, Elizabeth.
+Institution
+ Sullivan, Valerie K. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
+ Sullivan, Valerie K. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, United States.
+ Wallace, Amelia S. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
+ Wallace, Amelia S. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, United States.
+ Rooney, Mary R. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
+ Rooney, Mary R. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, United States.
+ Zhang, Sui. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
+ Zhang, Sui. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, United States.
+ Fang, Michael. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
+ Fang, Michael. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, United States.
+ Christenson, Robert H. Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, United States.
+ Selvin, Elizabeth. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
+ Selvin, Elizabeth. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, United States.
+MeSH Subject Headings
+ Humans
+ Adult
+ *Adiposity
+ Nutrition Surveys
+ Glycated Hemoglobin
+ Cross-Sectional Studies
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Serum Albumin/an [Analysis]
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus
+ Biomarkers
+Abstract
+ BACKGROUND: Glycated albumin (GA) is a short-term measure of glycemic control. Several studies have demonstrated an inverse association between body mass index (BMI) and GA, which may affect its performance as a biomarker of hyperglycemia. We investigated cross-sectional associations between GA and multiple measures of adiposity, and compared its performance as a glycemic biomarker by obesity status, in a nationally representative sample of US adults.
+
+ METHODS: We measured GA in adults from the 1999-2004 National Health and Nutrition Examination Survey. Separately in adults with and without diabetes, we assessed associations of GA with adiposity measures (BMI, waist circumference, trunk fat, total body fat, and fat mass index) in sex-stratified multivariable regression models. We compared sensitivity and specificity of GA to identify elevated hemoglobin A1c (HbA1c), by obesity status.
+
+ RESULTS: In covariate-adjusted regression models, all adiposity measures were inversely associated with GA in adults without diabetes (beta=-0.48 to -0.22%-point GA per 1 SD adiposity measure; n = 9750) and with diabetes (beta=-1.73 to -0.92%-point GA per SD). Comparing adults with vs without obesity, GA exhibited lower sensitivity (43% vs 54%) with equivalent specificity (99%) to detect undiagnosed diabetes (HbA1c >= 6.5%). Among adults with diagnosed diabetes (n = 1085), GA performed well to identify above-target glycemia (HbA1c >= 7.0%), with high specificity (>80%) overall but lower sensitivity in those with vs without obesity (81% vs 93%).
+
+ CONCLUSIONS: Inverse associations between GA and adiposity were present in people with and without diabetes. GA is highly specific but may not be sufficiently sensitive for diabetes screening in adults with obesity. Copyright © American Association for Clinical Chemistry 2023. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Glycated Hemoglobin). 0 (Serum Albumin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1093%2fjalm%2fjfad004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sullivan&issn=2576-9456&title=The+Journal+of+Applied+Laboratory+Medicine&atitle=Inverse+Associations+between+Measures+of+Adiposity+and+Glycated+Albumin+in+US+Adults%2C+NHANES+1999-2004.&volume=8&issue=4&spage=751&epage=762&date=2023&doi=10.1093%2Fjalm%2Fjfad004&pmid=36998214&sid=OVID:medline
+
+<279>
+Unique Identifier
+ 36986134
+Title
+ Omega-3-Supplemented Fat Diet Drives Immune Metabolic Response in Visceral Adipose Tissue by Modulating Gut Microbiota in a Mouse Model of Obesity.
+Source
+ Nutrients. 15(6), 2023 Mar 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Portela ND; Galvan C; Sanmarco LM; Bergero G; Aoki MP; Cano RC; Pesoa SA
+Author NameID
+ Portela, Nestor D; ORCID: https://orcid.org/0000-0003-4382-0896
+ Aoki, Maria P; ORCID: https://orcid.org/0000-0002-6897-7702
+ Cano, Roxana C; ORCID: https://orcid.org/0000-0003-4935-1832
+Authors Full Name
+ Portela, Nestor D; Galvan, Cristian; Sanmarco, Liliana M; Bergero, Gaston; Aoki, Maria P; Cano, Roxana C; Pesoa, Susana A.
+Institution
+ Portela, Nestor D. Departamento de Diagnostico Molecular, LACE Laboratorios, Cordoba X5000JJS, Argentina.
+ Portela, Nestor D. Unidad Asociada Area Ciencias Agrarias, Ingenieria, Ciencias Biologicas y de la Salud, Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Facultad de Ciencias Quimicas, Universidad Catolica de Cordoba, Cordoba X5016DHK, Argentina.
+ Galvan, Cristian. Departamento de Diagnostico Molecular, LACE Laboratorios, Cordoba X5000JJS, Argentina.
+ Galvan, Cristian. Unidad Asociada Area Ciencias Agrarias, Ingenieria, Ciencias Biologicas y de la Salud, Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Facultad de Ciencias Quimicas, Universidad Catolica de Cordoba, Cordoba X5016DHK, Argentina.
+ Sanmarco, Liliana M. Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI), Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Cordoba X5000HUA, Argentina.
+ Sanmarco, Liliana M. Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba X5000HUA, Argentina.
+ Bergero, Gaston. Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI), Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Cordoba X5000HUA, Argentina.
+ Bergero, Gaston. Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba X5000HUA, Argentina.
+ Aoki, Maria P. Centro de Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI), Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Cordoba X5000HUA, Argentina.
+ Aoki, Maria P. Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba X5000HUA, Argentina.
+ Cano, Roxana C. Unidad Asociada Area Ciencias Agrarias, Ingenieria, Ciencias Biologicas y de la Salud, Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Facultad de Ciencias Quimicas, Universidad Catolica de Cordoba, Cordoba X5016DHK, Argentina.
+ Cano, Roxana C. Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba X5000HUA, Argentina.
+ Pesoa, Susana A. Departamento de Diagnostico Molecular, LACE Laboratorios, Cordoba X5000JJS, Argentina.
+MeSH Subject Headings
+ Animals
+ Mice
+ *Gastrointestinal Microbiome
+ Intra-Abdominal Fat/me [Metabolism]
+ Obesity/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Body Weight
+ Fatty Acids, Omega-3/pd [Pharmacology]
+ Fatty Acids, Omega-3/me [Metabolism]
+ *Fatty Acids, Omega-3
+ Dietary Supplements
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Mice, Inbred C57BL
+Keyword Heading
+ Omega-3
+ adipose tissue macrophages
+ gut microbiota
+ high fat diet
+ immune-metabolism
+ obesity
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a chronic, relapsing, and multifactorial disease characterized by excessive accumulation of adipose tissue (AT), and is associated with inflammation mainly in white adipose tissue (WAT) and an increase in pro-inflammatory M1 macrophages and other immune cells. This milieu favors the secretion of cytokines and adipokines, contributing to AT dysfunction (ATD) and metabolic dysregulation. Numerous articles link specific changes in the gut microbiota (GM) to the development of obesity and its associated disorders, highlighting the role of diet, particularly fatty acid composition, in modulating the taxonomic profile. The aim of this study was to analyze the effect of a medium-fat-content diet (11%) supplemented with omega-3 fatty acids (D2) on the development of obesity, and on the composition of the GM compared with a control diet with a low fat content (4%) (D1) over a 6-month period. The effect of omega-3 supplementation on metabolic parameters and the modulation of the immunological microenvironment in visceral adipose tissue (VAT) was also evaluated. Six-weeks-old mice were adapted for two weeks and then divided into two groups of eight mice each: a control group D1 and the experimental group D2. Their body weight was recorded at 0, 4, 12, and 24 weeks post-differential feeding and stool samples were simultaneously collected to determine the GM composition. Four mice per group were sacrificed on week 24 and their VAT was taken to determine the immune cells phenotypes (M1 or M2 macrophages) and inflammatory biomarkers. Blood samples were used to determine the glucose, total LDL and HDL cholesterol LDL, HDL and total cholesterol, triglycerides, liver enzymes, leptin, and adiponectin. Body weight measurement showed significant differences at 4 (D1 = 32.0 +/- 2.0 g vs. D2 = 36.2 +/- 4.5 g, p-value = 0.0339), 12 (D1 = 35.7 +/- 4.1 g vs. D2 = 45.3 +/- 4.9 g, p-value = 0.0009), and 24 weeks (D1 = 37.5 +/- 4.7 g vs. D2 = 47.9 +/- 4.7, p-value = 0.0009). The effects of diet on the GM composition changed over time: in the first 12 weeks, alpha and beta diversity differed considerably according to diet and weight increase. In contrast, at 24 weeks, the composition, although still different between groups D1 and D2, showed changes compared with previous samples, suggesting the beneficial effects of omega-3 fatty acids in D2. With regard to metabolic analysis, the results did not reveal relevant changes in biomarkers in accordance with AT studies showing an anti-inflammatory environment and conserved structure and function, which is in contrast to reported findings for pathogenic obesity. In conclusion, the results suggest that the constant and sustained administration of omega-3 fatty acids induced specific changes in GM composition, mainly with increases in Lactobacillus and Ligilactobacillus species, which, in turn, modulated the immune metabolic response of AT in this mouse model of obesity.
+Registry Number/Name of Substance
+ 0 (Fatty Acids, Omega-3). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fnu15061404
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Portela&issn=2072-6643&title=Nutrients&atitle=Omega-3-Supplemented+Fat+Diet+Drives+Immune+Metabolic+Response+in+Visceral+Adipose+Tissue+by+Modulating+Gut+Microbiota+in+a+Mouse+Model+of+Obesity.&volume=15&issue=6&spage=&epage=&date=2023&doi=10.3390%2Fnu15061404&pmid=36986134&sid=OVID:medline
+
+<280>
+Unique Identifier
+ 36982669
+Title
+ Impact of Obesity on the IL-6 Immune Marker and Th17 Immune Cells in C57BL/6 Mice Models with Imiquimod-Induced Psoriasis.
+Source
+ International Journal of Molecular Sciences. 24(6), 2023 Mar 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Park SH; Lee KA; Choi JH; Park S; Kim DW; Jung SY
+Author NameID
+ Park, So Hee; ORCID: https://orcid.org/0000-0002-9600-799X
+ Lee, Kyung Ah; ORCID: https://orcid.org/0000-0002-3131-1253
+ Jung, So Young; ORCID: https://orcid.org/0000-0003-0155-5473
+Authors Full Name
+ Park, So Hee; Lee, Kyung Ah; Choi, Jae-Hyeog; Park, SaeGwang; Kim, Dae-Wook; Jung, So Young.
+Institution
+ Park, So Hee. Department of Dermatology, Haeundae Paik Hospital, College of Medicine, Inje University, Busan 48108, Republic of Korea.
+ Lee, Kyung Ah. Department of Plastic and Reconstructive Surgery, Haeundae Paik Hospital, College of Medicine, Inje University, Busan 48108, Republic of Korea.
+ Choi, Jae-Hyeog. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDIhub), Daegu 41061, Republic of Korea.
+ Park, SaeGwang. Department of Microbiology and Immunology, College of Medicine, Inje University, Busan 47392, Republic of Korea.
+ Kim, Dae-Wook. Department of Orthopedic Surgery, Haeundae Paik Hospital, College of Medicine, Inje University, Busan 48108, Republic of Korea.
+ Jung, So Young. Department of Dermatology, Haeundae Paik Hospital, College of Medicine, Inje University, Busan 48108, Republic of Korea.
+MeSH Subject Headings
+ Mice
+ Animals
+ Imiquimod/ae [Adverse Effects]
+ Interleukin-6/ae [Adverse Effects]
+ *Interleukin-6
+ Th17 Cells
+ Mice, Inbred C57BL
+ Psoriasis/dt [Drug Therapy]
+ *Psoriasis
+ Skin/pa [Pathology]
+ Cytokines/tu [Therapeutic Use]
+ Obesity/et [Etiology]
+ Obesity/pa [Pathology]
+ Biomarkers
+ Disease Models, Animal
+Keyword Heading
+ IL-6
+ Th17
+ imiquimod
+ obesity
+ psoriasis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obese psoriatic patients experience higher disease severity and exhibit poorer treatment responses and clinical outcomes. It has been proposed that proinflammatory cytokines produced by adipose tissue exacerbate psoriasis; however, the role of obesity in psoriasis remains unclear. This study aimed to elucidate the role of obesity in the pathogenesis of psoriasis, focusing on immunological changes. To induce obesity, mice were fed a high-fat diet for 20 weeks. We then applied imiquimod to the skin on a mouse's back for seven consecutive days to induce psoriasis and scored lesion severity every day for seven days. Cytokine levels in serum and the Th17 cell population in the spleen and draining lymph nodes were studied to identify immunological differences. The clinical severity was more remarkable, and histologically the epidermis was also significantly thicker in the obese group. Increased levels of IL-6 and TNF-alpha were observed in serum after psoriasis. They were elevated to a greater degree, with greater expansion of the functional Th17 cell population in the obese group. It is concluded that obesity could exacerbate psoriasis through mechanisms that involve elevated proinflammatory cytokine secretion and an expanded Th17 cell population.
+Registry Number/Name of Substance
+ P1QW714R7M (Imiquimod). 0 (Interleukin-6). 0 (Cytokines). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fijms24065592
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Park&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Impact+of+Obesity+on+the+IL-6+Immune+Marker+and+Th17+Immune+Cells+in+C57BL%2F6+Mice+Models+with+Imiquimod-Induced+Psoriasis.&volume=24&issue=6&spage=5592&epage=&date=2023&doi=10.3390%2Fijms24065592&pmid=36982669&sid=OVID:medline
+
+<281>
+Unique Identifier
+ 36973700
+Title
+ Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults.
+Source
+ BMC Endocrine Disorders. 23(1):67, 2023 Mar 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abbasi MSP; Tousi AZ; Yazdani Y; Vahdat S; Gharebakhshi F; Nikrad N; Manzouri A; Ardekani AM; Jafarzadeh F
+Authors Full Name
+ Abbasi, Mohammad Sadegh Pour; Tousi, Ayda Zahiri; Yazdani, Yalda; Vahdat, Sahar; Gharebakhshi, Farshad; Nikrad, Negin; Manzouri, Ali; Ardekani, Abnoos Mokhtari; Jafarzadeh, Faria.
+Institution
+ Abbasi, Mohammad Sadegh Pour. Department of Cardiovascular Surgery, Kashan University of Medical Sciences, Kashan, Iran.
+ Tousi, Ayda Zahiri. Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran.
+ Yazdani, Yalda. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Vahdat, Sahar. Isfahan Kidney Disease Research Center, School of Medicine, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Gharebakhshi, Farshad. Department of Radiology, School of Medicne, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Nikrad, Negin. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Manzouri, Ali. Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
+ Ardekani, Abnoos Mokhtari. Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science, & Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. amokhtari@kmu.ac.ir.
+ Jafarzadeh, Faria. Department of Internal Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnourd, Iran.
+MeSH Subject Headings
+ Adult
+ Humans
+ Middle Aged
+ Young Adult
+ *Betaine
+ Cholesterol/bl [Blood]
+ *Choline
+ Diet/sn [Statistics & Numerical Data]
+ *Diet
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ *Obesity
+ Overweight/bl [Blood]
+ Overweight/ep [Epidemiology]
+ Overweight/me [Metabolism]
+ Prevalence
+ Risk Factors
+ Triglycerides/bl [Blood]
+ *Cardiometabolic Risk Factors
+ Eating
+ Biomarkers/bl [Blood]
+Keyword Heading
+ Betaine
+ Blood pressure
+ Choline
+ Lipid profile
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine. There are numerous studies with inconsistent results that evaluated the association between dietary choline intakes with cardiovascular risk factors. In addition, the association between dietary betaine and choline intakes with cardio-metabolic risk factors is not well studied. In the current study, our aim was to evaluate dietary choline and betaine intakes in the usual diet of obese individuals and to assess its association with serum lipids, blood pressure and glycemic markers among obese individuals.
+
+ METHODS: We recruited a total number of 359 obese people aged between 20 and 50 years in the present study. A semi-quantitative food frequency questionnaire (FFQ) was used for dietary assessment; dietary choline and betaine intakes were calculated using the United States Department of Agriculture (USDA) database. National cholesterol education program adult treatment panel (NCEP-ATP)-III criteria was used metabolic syndrome (MetS) definition. Enzymatic methods were used to assess biochemical variables. Body composition was measured with the bioelectrical impedance analysis (BIA) method.
+
+ RESULTS: Higher body mass index (BMI), waist to hip ratio (WHR), fat-free mass (FFM) and basal metabolic rate (BMR) were observed in higher tertiles of dietary choline intake (P < 0.01). There was no significant difference in terms of biochemical parameters among different tertiles of dietary choline intake, while systolic blood pressure (SBP) and diastolic blood pressure (DBP) were reduced in higher betaine tertiles (P < 0.05). For total dietary choline and betaine intakes, there was a reduction in DBP and low density lipoprotein (LDL) concentrations (P < 0.05). Also, a non-significant reduction in serum total cholesterol (TC), triglyceride (TG) and MetS prevalence was observed in higher tertiles of dietary choline and betaine intakes. After classification of the study population according to MetS status, there was no significant difference in biochemical variables in subjects with MetS (P > 0.05), while in the non-MetS group, SBP, DBP, TG and insulin levels reduced in higher tertiles of dietary betaine and choline (P > 0.05).
+
+ CONCLUSION: According to our findings, higher dietary intakes of choline and betaine were associated with lower levels of blood pressure and LDL concentrations among obese individuals. Further studies are warranted to confirm the results of the current study. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 3SCV180C9W (Betaine). 97C5T2UQ7J (Cholesterol). N91BDP6H0X (Choline). 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1186%2fs12902-023-01323-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abbasi&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Dietary+choline+and+betaine+intake%2C+cardio-metabolic+risk+factors+and+prevalence+of+metabolic+syndrome+among+overweight+and+obese+adults.&volume=23&issue=1&spage=67&epage=&date=2023&doi=10.1186%2Fs12902-023-01323-4&pmid=36973700&sid=OVID:medline
+
+<282>
+Unique Identifier
+ 36961308
+Title
+ Transcriptomics integrated with metabolomics reveals the ameliorating effect of mussel-derived plasmalogens on high-fat diet-induced hyperlipidemia in zebrafish.
+Source
+ Food & Function. 14(8):3641-3658, 2023 Apr 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Feng J; Chen X; Wang S; Zhang J; Wang Q; Guo S; Shen Q
+Author NameID
+ Feng, Junli; ORCID: http://orcid.org/0000-0002-8159-3842
+Authors Full Name
+ Feng, Junli; Chen, Xi; Wang, Shitong; Zhang, Jian; Wang, Qingcheng; Guo, Shunyuan; Shen, Qing.
+Institution
+ Feng, Junli. Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China. leonqshen@163.com.
+ Chen, Xi. Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.
+ Wang, Shitong. Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China. leonqshen@163.com.
+ Zhang, Jian. Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China. leonqshen@163.com.
+ Wang, Qingcheng. Department of Cardiology, Hangzhou Linping Hospital of Traditional Chinese Medicine, Linping 311106, Zhejiang, China.
+ Guo, Shunyuan. Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.
+ Shen, Qing. Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China. leonqshen@163.com.
+MeSH Subject Headings
+ Animals
+ Mice
+ Hyperlipidemias/et [Etiology]
+ Hyperlipidemias/ge [Genetics]
+ *Hyperlipidemias
+ Zebrafish/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Plasmalogens/pd [Pharmacology]
+ Transcriptome
+ Neurodegenerative Diseases/me [Metabolism]
+ *Neurodegenerative Diseases
+ Metabolomics/mt [Methods]
+ Liver/me [Metabolism]
+ Obesity/et [Etiology]
+ Obesity/ge [Genetics]
+ Lipid Metabolism
+ Cholesterol/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Mice, Inbred C57BL
+Abstract
+ Plasmalogens (Pls), a special group of phospholipids, are effective in ameliorating neurodegenerative disease. In the present study, the metabolic effects of seafood-derived Pls on high fat diet (HFD)-induced hyperlipidemia in zebrafish were evaluated, and the underlying mechanisms of dietary Pls against hyperlipidemia were explored through integrated analyses of hepatic transcriptomics and metabolomics. The results demonstrated that Pls supplementation could effectively alleviate HFD-induced obesity symptoms, such as body weight gain, and decrease total hepatic cholesterol and triglyceride levels. Integrated hepatic transcriptome and metabolome data suggested that Pls mainly altered lipid metabolism pathways (FA metabolism, primary bile acid biosynthesis, steroid hormone biosynthesis, and glycerolipid and glycerophospholipid metabolism) and the TCA cycle, induced the overexpression of anti-oxidation enzymes (Cat, Gpx4, Sod3a and Xdh), reduced disease biomarkers (such as glutarylcarnitine, gamma-glutamyltyrosine, and 11-prostaglandin f2) and gut microbiota-derived metabolites, and increased (+/-)12(13)-diHOME, EPA, lysoPC and PC levels. Moreover, 5 abnormally regulated metabolites were identified as potential biomarkers associated with hyperlipidemia according to the metabolomics results and suggested the involvement of gut microbiota in the anti-hyperlipidemic effects of Pls. Collectively, these findings suggest that the protective role of Pls is mainly associated with the promotion of unsaturated fatty acid biosynthesis and cholesterol efflux, lipid and phospholipid PUFA remodeling, and anti-oxidation and anti-inflammatory capabilities. This study provides valuable information for reasonably explaining the beneficial effects of seafood-derived Pls in alleviating hyperlipidemia and thus may contribute to the development and application of Pls as functional foods or dietary supplements to protect against obesity and hyperlipidemia.
+Registry Number/Name of Substance
+ 0 (Plasmalogens). 97C5T2UQ7J (Cholesterol). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1039%2fd3fo00063j
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Feng&issn=2042-6496&title=Food+%26+Function&atitle=Transcriptomics+integrated+with+metabolomics+reveals+the+ameliorating+effect+of+mussel-derived+plasmalogens+on+high-fat+diet-induced+hyperlipidemia+in+zebrafish.&volume=14&issue=8&spage=3641&epage=3658&date=2023&doi=10.1039%2Fd3fo00063j&pmid=36961308&sid=OVID:medline
+
+<283>
+Unique Identifier
+ 36958578
+Title
+ The PERInatal MYocardial Remodeling (PERIMYR) cohort study protocol: A prospective study of cardiac remodeling and "recovery" in pregnancy as a model to understand the impact of comorbidities in cardiac remodeling and reverse remodeling.
+Source
+ Revista Portuguesa de Cardiologia. 42(6):585-596, 2023 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ferreira AF; Azevedo MJ; Saraiva FA; Trindade F; Barros A; Leite S; Proenca T; Sousa C; Machado AP; Leite-Moreira A; Sampaio-Maia B; Ramalho C; Falcao-Pires I
+Authors Full Name
+ Ferreira, Ana Filipa; Azevedo, Maria Joao; Saraiva, Francisca Almeida; Trindade, Fabio; Barros, Antonio; Leite, Sara; Proenca, Tania; Sousa, Carla; Machado, Ana Paula; Leite-Moreira, Adelino; Sampaio-Maia, Benedita; Ramalho, Carla; Falcao-Pires, Ines.
+Institution
+ Ferreira, Ana Filipa. Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal.
+ Azevedo, Maria Joao. Faculdade de Medicina Dentaria, Universidade do Porto, Portugal; INEB - Instituto Nacional de Engenharia Biomedica, Portugal; i3S - Instituto de Investigacao e Inovacao em Saude, Universidade do Porto, Portugal; Academic Center for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands.
+ Saraiva, Francisca Almeida. Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal.
+ Trindade, Fabio. Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal.
+ Barros, Antonio. Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal.
+ Leite, Sara. Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal; Anta Family Health Unit/Espinho/Gaia Healthcare Center, Espinho, Portugal.
+ Proenca, Tania. Cardiology Department, Centro Hospitalar de Sao Joao, Porto, Portugal.
+ Sousa, Carla. Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal; Cardiology Department, Centro Hospitalar de Sao Joao, Porto, Portugal.
+ Machado, Ana Paula. Center of Prenatal Diagnosis, Obstetrics Department, Sao Joao Hospital, Porto, Portugal.
+ Leite-Moreira, Adelino. Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal; Cardiothoracic Surgery Department, Centro Hospitalar de Sao Joao, Porto, Portugal.
+ Sampaio-Maia, Benedita. Faculdade de Medicina Dentaria, Universidade do Porto, Portugal; INEB - Instituto Nacional de Engenharia Biomedica, Portugal; i3S - Instituto de Investigacao e Inovacao em Saude, Universidade do Porto, Portugal.
+ Ramalho, Carla. Center of Prenatal Diagnosis, Obstetrics Department, Sao Joao Hospital, Porto, Portugal; Obstetrics, Gynecology and Pediatrics Department, Faculty of Medicine of the University of Porto, Portugal.
+ Falcao-Pires, Ines. Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal. Electronic address: ipires@med.up.pt.
+MeSH Subject Headings
+ Animals
+ Female
+ Humans
+ Pregnancy
+ Prospective Studies
+ Cohort Studies
+ Ventricular Remodeling/ph [Physiology]
+ Pulse Wave Analysis
+ Heart Failure/dt [Drug Therapy]
+ *Heart Failure
+ Obesity
+ *Diabetes Mellitus
+ Biomarkers
+ *Hypertension
+ Ventricular Function, Left/ph [Physiology]
+Keyword Heading
+ Cardiac function
+ Cardiovascular remodeling
+ Comorbidities
+ Comorbilidades
+ Diabetes
+ Diabetes mellitus
+ Funcao cardiaca
+ Gravidez
+ Gravida
+ Hemodynamic overload
+ Hipertensao arterial
+ Hypertension
+ Obesidade
+ Obesity
+ Post-partum
+ Pregnancy
+ Pregnant woman
+ Pos-parto
+ Remodelagem cardiovascular
+ Remodelagem reversa
+ Reverse remodeling
+ Sobrecarga hemodinamica
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Heart failure (HF) is among the leading causes of morbidity and mortality worldwide. Several conditions trigger left ventricular chronic pressure or volume overload, hypertrophy, systolic and diastolic dysfunction, leading to cardiac remodeling and a rapid progression toward HF. Therapeutic interventions elicit reverse remodeling (RR), a highly variable myocardial response that ranges from none to total ventricular structural/functional recovery. However, HF patients present several comorbidities and medications that mask a comprehensive molecular knowledge of RR and hinder the identification of potential biomarkers of its progression or prognosis. Therefore, instead of using this heterogeneous population or even animal models to understand myocardial remodeling, we propose studying pregnancy-induced cardiovascular remodeling and postpartum-induced RR.
+
+ OBJECTIVES: To assess cardiovascular functional and structural adaptations during pregnancy and in postpartum, characterizing the associated molecular changes; as well as to explore the impact of hypertension, obesity and diabetes on these processes.
+
+ METHODS: We will perform echocardiography and assess endothelial function and arterial stiffness (EndoPAT R and pulse wave velocity, respectively) and assess potential markers of remodeling and RR using plasma and urine samples from pregnant women. To translate to a HF context, we will determine the impact of risk factors (hypertension, obesity and diabetes) by studying subgroups of pregnant women with these comorbidities.
+
+ RESULTS: Not applicable.
+
+ CONCLUSION: We are convinced that understanding the impact of these comorbidities in such a homogeneous population, such as pregnant women, provides a valuable model to unveil the most relevant pathologic and often masked signaling pathways underlying cardiac remodeling and incomplete RR in a heterogeneous population, such as HF patients. Moreover, we expect to identify potential novel biomarkers of RR progression/prognosis more easily. Copyright © 2023 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier Espana, S.L.U. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.repc.2022.08.015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ferreira&issn=0870-2551&title=Revista+Portuguesa+de+Cardiologia&atitle=The+PERInatal+MYocardial+Remodeling+%28PERIMYR%29+cohort+study+protocol%3A+A+prospective+study+of+cardiac+remodeling+and+%22recovery%22+in+pregnancy+as+a+model+to+understand+the+impact+of+comorbidities+in+cardiac+remodeling+and+reverse+remodeling.&volume=42&issue=6&spage=585&epage=596&date=2023&doi=10.1016%2Fj.repc.2022.08.015&pmid=36958578&sid=OVID:medline
+
+<284>
+Unique Identifier
+ 36952563
+Title
+ Circulating microRNAs as potential biomarkers of early vascular damage in vitamin D deficiency, obese, and diabetic patients.
+Source
+ PLoS ONE [Electronic Resource]. 18(3):e0283608, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elmoselhi AB; Seif Allah M; Bouzid A; Ibrahim Z; Venkatachalam T; Siddiqui R; Khan NA; Hamoudi RA
+Author NameID
+ Elmoselhi, Adel B; ORCID: https://orcid.org/0000-0003-2152-6629
+ Hamoudi, Rifat A; ORCID: https://orcid.org/0000-0002-1402-0868
+Authors Full Name
+ Elmoselhi, Adel B; Seif Allah, Mohamed; Bouzid, Amal; Ibrahim, Zeinab; Venkatachalam, Thenmozhi; Siddiqui, Ruqaiyyah; Khan, Naveed Ahmed; Hamoudi, Rifat A.
+Institution
+ Elmoselhi, Adel B. College of Medicine, University of Sharjah, Sharjah, UAE.
+ Elmoselhi, Adel B. Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE.
+ Seif Allah, Mohamed. College of Medicine, University of Sharjah, Sharjah, UAE.
+ Seif Allah, Mohamed. Cardiology Department, University Hospital Sharjah, Sharjah, UAE.
+ Bouzid, Amal. Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE.
+ Ibrahim, Zeinab. Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE.
+ Venkatachalam, Thenmozhi. Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE.
+ Siddiqui, Ruqaiyyah. College of Arts and Sciences, American University of Sharjah, University City, Sharjah, UAE.
+ Khan, Naveed Ahmed. College of Medicine, University of Sharjah, Sharjah, UAE.
+ Khan, Naveed Ahmed. Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE.
+ Hamoudi, Rifat A. College of Medicine, University of Sharjah, Sharjah, UAE.
+ Hamoudi, Rifat A. Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE.
+MeSH Subject Headings
+ Middle Aged
+ Humans
+ *Circulating MicroRNA
+ Pulse Wave Analysis
+ Biomarkers
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ Obesity/co [Complications]
+ Vitamin D Deficiency/co [Complications]
+ Vitamin D Deficiency/di [Diagnosis]
+ *Vitamin D Deficiency
+ *Diabetes Mellitus
+ Vitamin D
+Abstract
+ Vitamin D3 deficiency, obesity, and diabetes mellitus (DM) have been shown to increase the risk of cardiovascular diseases (CVDs). However, the early detection of vascular damage in those patients is still difficult to ascertain. MicroRNAs (miRNAs) are recognized to play a critical role in initiation and pathogenesis of vascular dysfunction. Herein, we aimed to identify circulating miRNA biomarkers of vascular dysfunction as early predictors of CVDs. We have recruited 23 middle-aged Emiratis patients with the following criteria: A healthy control group with vitamin D >= 20ng, and BMI < 30 (C1 group = 11 individuals); A vitamin D deficiency (Vit D level <= 20 ng) and obese (BMI >= 30) group (A1 group = 9 patients); A vitamin D deficiency, obese, plus DM (A2 group = 3 patients). Arterial stiffness via pulse wave velocity (PWV) was measured and the whole transcriptome analysis with qPCR validation for miRNA in plasma samples were tested. PWV relative to age was significantly higher in A1 group 19.4 +/- 4.7 m/s and A2 group 18.3 +/- 1.3 m/s compared to controls 14.7 +/- 2.1 m/s (p < 0.05). Similar patterns were also observed in the Augmentation pressure (AP) and Alx%. Whole RNA-Sequencing revealed miR-182-5p; miR-199a-5p; miR-193a-5p; and miR-155-5p were differentially over-expressed (logFC > 1.5) in high-risk patients for CVDs vs healthy controls. Collectively, our result indicates that four specific circulating miRNA signature, may be utilized as non-invasive, diagnostic and prognostic biomarkers for early vascular damage in patients suffering from vitamin D deficiency, obesity and DM. Copyright: © 2023 Elmoselhi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
+Registry Number/Name of Substance
+ 0 (Circulating MicroRNA). 0 (Biomarkers). 0 (MicroRNAs). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1371%2fjournal.pone.0283608
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elmoselhi&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Circulating+microRNAs+as+potential+biomarkers+of+early+vascular+damage+in+vitamin+D+deficiency%2C+obese%2C+and+diabetic+patients.&volume=18&issue=3&spage=e0283608&epage=&date=2023&doi=10.1371%2Fjournal.pone.0283608&pmid=36952563&sid=OVID:medline
+
+<285>
+Unique Identifier
+ 36947289
+Title
+ Comparative Accuracy of Clinical Fibrosis Markers, Hepascore and Fibroscan R to Detect Advanced Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.
+Source
+ Digestive Diseases & Sciences. 68(6):2757-2767, 2023 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bertot LC; Jeffrey GP; de Boer B; Wang Z; Huang Y; Garas G; MacQuillan G; Wallace M; Smith BW; Adams LA
+Author NameID
+ Adams, Leon A; ORCID: http://orcid.org/0000-0002-3968-7909
+Authors Full Name
+ Bertot, Luis C; Jeffrey, Gary P; de Boer, Bastiaan; Wang, Zhengyi; Huang, Yi; Garas, George; MacQuillan, Gerry; Wallace, Michael; Smith, Briohny W; Adams, Leon A.
+Institution
+ Bertot, Luis C. Medical School, University of Western Australia, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Jeffrey, Gary P. Medical School, University of Western Australia, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Jeffrey, Gary P. Department of Hepatology, Sir Charles Gairdner Hospital, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ de Boer, Bastiaan. Department of Anatomical Pathology, Pathwest, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Wang, Zhengyi. Medical School, University of Western Australia, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Huang, Yi. Medical School, University of Western Australia, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Garas, George. Department of Hepatology, Sir Charles Gairdner Hospital, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ MacQuillan, Gerry. Department of Hepatology, Sir Charles Gairdner Hospital, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Wallace, Michael. Medical School, University of Western Australia, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Wallace, Michael. Department of Hepatology, Sir Charles Gairdner Hospital, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Smith, Briohny W. Department of Hepatology, Sir Charles Gairdner Hospital, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia.
+ Adams, Leon A. Medical School, University of Western Australia, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia. leon.adams@uwa.edu.au.
+ Adams, Leon A. Department of Hepatology, Sir Charles Gairdner Hospital, QEII Medical Campus, Verdun St, Nedlands, WA, 6009, Australia. leon.adams@uwa.edu.au.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ *Non-alcoholic Fatty Liver Disease
+ Liver/dg [Diagnostic Imaging]
+ Liver/pa [Pathology]
+ Severity of Illness Index
+ Liver Cirrhosis/dg [Diagnostic Imaging]
+ Liver Cirrhosis/et [Etiology]
+ Fibrosis
+ Biomarkers
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Biopsy
+ Aspartate Aminotransferases
+Keyword Heading
+ Diagnosis
+ Elastography
+ Liver biopsy
+ Non-invasive fibrosis models
+ Nonalcoholic fatty liver disease
+ Nonalcoholic steatohepatitis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Non-invasive tests are widely used to diagnose fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), however, the optimal method remains unclear. We compared the accuracy of simple serum models, a serum model incorporating direct measures of fibrogenesis (Hepascore), and Fibroscan R, for detecting fibrosis in NAFLD.
+
+ METHODS: NAFLD patients undergoing liver biopsy were evaluated with Hepascore, NAFLD Fibrosis Score (NFS), FIB-4 and AST-platelet ratio index (APRI), with a subset (n = 131) undergoing Fibroscan R. Fibrosis on liver biopsy was categorized as advanced (F3-4) or cirrhosis (F4). Accuracy was determined by area under receiving operating characteristic curves (AUC). Indeterminate ranges were calculated using published cut-offs.
+
+ RESULTS: In 271 NAFLD patients, 83 (31%) had F3-4 and 47 (17%) cirrhosis. 6/131 (4%) had an unreliable Fibroscan R. For the detection of advanced fibrosis, the accuracy of Hepascore (AUC 0.88) was higher than FIB-4 (0.73), NFS (0.72) and APRI (0.69) (p < 0.001 for all). Hepascore had similar accuracy to Fibroscan R (0.80) overall, but higher accuracy in obese individuals (0.91 vs 0.80, p = 0.001). Hepascore more accurately identified patients with cirrhosis than APRI (AUC 0.85 vs 0.71, p = 0.01) and NFS (AUC 0.73, p = 0.01) but performed similar to FIB-4 and Fibroscan R. For the determination of F3-4, the proportion of patients in indeterminate area was lower for Hepascore (4.8%), compared to FIB-4 (42%), NFS (36%) and APRI (44%) (p < 0.001 for all).
+
+ CONCLUSIONS: Hepascore has greater accuracy and a lower indeterminate range than simple serum fibrosis tests for advanced fibrosis in NAFLD, and greater accuracy than Fibroscan R in obese individuals. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-1 (Aspartate Aminotransferases).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs10620-023-07896-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bertot&issn=0163-2116&title=Digestive+Diseases+%26+Sciences&atitle=Comparative+Accuracy+of+Clinical+Fibrosis+Markers%2C+Hepascore+and+Fibroscan+R+to+Detect+Advanced+Fibrosis+in+Patients+with+Nonalcoholic+Fatty+Liver+Disease.&volume=68&issue=6&spage=2757&epage=2767&date=2023&doi=10.1007%2Fs10620-023-07896-3&pmid=36947289&sid=OVID:medline
+
+<286>
+Unique Identifier
+ 36930549
+Title
+ Soluble receptor for advanced glycation end products and lipid profile ratio as cardiovascular risk markers in children with obesity.
+Original Title
+ Receptor soluble para productos finales de glicacion avanzada y perfil lipidico como marcadores de riesgo cardiovascular en ninos con obesidad.
+Source
+ Gaceta Medica de Mexico. 159(1):10-16, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Flores-Ramirez AG; Ibarra-Reynoso LDR; Garay-Sevilla ME
+Authors Full Name
+ Flores-Ramirez, Anaisa G; Ibarra-Reynoso, Lorena Del R; Garay-Sevilla, Ma Eugenia.
+Institution
+ Flores-Ramirez, Anaisa G. Department of Medical Sciences, Division of Heath Sciences, Universidad de Guanajuato, Campus Leon, Guanajuato, Mexico.
+ Ibarra-Reynoso, Lorena Del R. Department of Medical Sciences, Division of Heath Sciences, Universidad de Guanajuato, Campus Leon, Guanajuato, Mexico.
+ Garay-Sevilla, Ma Eugenia. Department of Medical Sciences, Division of Heath Sciences, Universidad de Guanajuato, Campus Leon, Guanajuato, Mexico.
+MeSH Subject Headings
+ Male
+ Humans
+ Child
+ Female
+ Glycation End Products, Advanced
+ Receptor for Advanced Glycation End Products
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Cross-Sectional Studies
+ Risk Factors
+ Obesity/co [Complications]
+ *Insulin Resistance
+ Glucose
+ Triglycerides
+ Heart Disease Risk Factors
+ Cholesterol
+ Biomarkers
+ Blood Glucose/me [Metabolism]
+Keyword Heading
+ Children
+ Ninos
+ Obesidad
+ Obesity
+ Relacion trigliceridos/C-HDL
+ TG/HDL-C ratio
+ sRAGE
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity has been shown to be associated with low levels of soluble receptor for advanced glycation end products (sRAGE).
+
+ OBJECTIVE: To evaluate the levels of sRAGE and its association with the lipid index in children with obesity.
+
+ METHODS: Cross-sectional study of children with obesity aged between six and 11 years. Anthropometric measurements, glucose, lipid profile, insulin and sRAGE were evaluated; body mass index, total cholesterol/high-density cholesterol (TC/HDL-C), triglycerides/glucose (TG/glucose), and triglycerides/HDL-C (TG-HDL-C) ratios and HOMA-IR were also calculated.
+
+ RESULTS: Eighty children were studied, among which 50% were males and 50% females. Females had higher values for waist circumference, HOMA-IR, and TG/HDL-C and TG/glucose ratios. No significant differences were found for sRAGE. When the variables were compared according to TG/HDL-C ratio tertiles, higher TC/HDL, TG/glucose, and sRAGE values were found at upper tertile. A significant correlation was observed between sRAGE and HOMA-IR (p < 0.03) in males, and between sRAGE and TG/HDL-C (p < 0.01) and TG/glucose ratios (p < 0.008) in females.
+
+ CONCLUSIONS: The female gender showed more cardiovascular risk factors and higher sRAGE at TG/HDL-C upper tertile. Further studies are required to test the possible predictive effect of higher risk for developing metabolic and cardiovascular complications. Copyright: © 2023 Permanyer.
+Other Abstract
+ Publisher
+ INTRODUCCION: Se ha mostrado que la obesidad esta asociada a niveles bajos de la forma soluble del receptor para productos finales de glicacion avanzada (sRAGE).
+ OBJETIVO: Evaluar los niveles de sRAGE y su asociacion con el indice lipidico en ninos con obesidad.
+ METODOS: Estudio transversal de ninos de seis a 11 anos de edad con obesidad. Se evaluaron medidas antropometricas, glucosa, perfil lipidico, insulina y sRAGE; tambien se calculo indice de masa corporal, colesterol total/C-HDL, trigliceridos/glucosa, trigliceridos/C-HDL y HOMA-IR.
+ RESULTADOS: Se estudiaron 80 ninos, 50 % hombres y 50 % mujeres. Las mujeres presentaron mayor perimetro de cintura, HOMA-IR, trigliceridos/C-HDL y trigliceridos/glucosa. No se encontraron diferencias significativas en sRAGE. Al comparar las variables conforme a los terciles de la relacion trigliceridos/C-HDL, en el tercil superior se encontraron mayores valores de colesterol total/HDL, trigliceridos/glucosa y sRAGE. Se observo correlacion significativa entre sRAGE y HOMA-IR (p < 0.03) en los hombres y entre sRAGE, trigliceridos/C-HDL (p < 0.01) y trigliceridos/glucosa (p < 0.008) en las mujeres.
+ CONCLUSIONES: El sexo femenino mostro mas factores de riesgo cardiovascular y mayor sRAGE en el tercil superior de trigliceridos/C-HDL. Se requieren mas estudios para probar el posible efecto predictor de mayor riesgo para desarrollar complicaciones metabolicas y cardiovasculares.
+ Language: Spanish
+Registry Number/Name of Substance
+ 0 (Glycation End Products, Advanced). 0 (Receptor for Advanced Glycation End Products). IY9XDZ35W2 (Glucose). 0 (Triglycerides). 97C5T2UQ7J (Cholesterol). 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.24875%2fGMM.M22000736
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Flores-Ramirez&issn=0016-3813&title=Gaceta+Medica+de+Mexico&atitle=Receptor+soluble+para+productos+finales+de+glicacion+avanzada+y+perfil+lipidico+como+marcadores+de+riesgo+cardiovascular+en+ninos+con+obesidad.&volume=159&issue=1&spage=10&epage=16&date=2023&doi=10.24875%2FGMM.M22000736&pmid=36930549&sid=OVID:medline
+
+<287>
+Unique Identifier
+ 36930468
+Title
+ Effect of ten different biomarkers in the gingival crevicular fluid of obese and non-obese undergoing fixed orthodontic treatment.
+Source
+ European Review for Medical & Pharmacological Sciences. 27(5):1722-1728, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alqerban A; Asiri SN; Alharbi F; Almalki A; Alqhtani N; Alenazi A; Robaian A; Samran A
+Authors Full Name
+ Alqerban, A; Asiri, S N; Alharbi, F; Almalki, A; Alqhtani, N; Alenazi, A; Robaian, A; Samran, A.
+Institution
+ Alqerban, A. Department of Preventive Dental Sciences, Department of Oral and Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia. a.alqerban@psau.edu.sa.
+MeSH Subject Headings
+ Male
+ Female
+ Humans
+ *Gingival Crevicular Fluid
+ *Leptin
+ Matrix Metalloproteinase 8
+ Matrix Metalloproteinase 9
+ Cross-Sectional Studies
+ Adiponectin
+ Obesity
+ Biomarkers/an [Analysis]
+Abstract
+ OBJECTIVE: The aim of this study is to evaluate the effect of ten proinflammatory cytokines in GCF of participants with raised body mass index (BMI) compared to non-obese subjects undergoing fixed orthodontic treatment.
+
+ PATIENTS AND METHODS: In the cross-sectional cohort, subjects were shortlisted through the purposive sampling method with the same age and gender and similar characteristics (cohort). For inclusion and exclusion, predefined criteria were followed. In all included participants obese and non-obese collection of GCF was made from mandibular canine to canine. Identification of inflammatory mediators (MPO and CRP) leptin, adiponectin, and resistin (pg/mL). Bone remodeling biomarkers RANKL (pg/mL) and tissue remodeling biomarkers MMP8, MMP9, TIMP1, and MMP8/TIMP1, MMP9/TIMP1 ratio were collected and blinded by the investigator. Normal distribution of data i.e., age, BMI, the flow rate of GCF, indices plaque and gingival, and uWMS were compared using a t-test. Non-normality biomarker data were evaluated using Mann-Whitney U-test. To assess the relationship between the concentration of GCF biomarkers and plaque and gingival indices Pearson and Spearman correlation coefficients were used.
+
+ RESULTS: The total number of participants included was 44. In the obese and non-obese groups, the male/female ratio was the same i.e., (n=11 each). The mean age of participants in the obese group was (25.7+/-1.55 years), whereas the non-obese group was (26.1+/-1.29 years). In obese the mean BMI was (33.6+/-2.1 kg/m2) whereas in non-obese (22.9+/-1.9 kg/m2) (p<0.02). Among the levels of biomarkers adiponectin (p<0.006) and leptin (p<0.028) demonstrated a significant difference between obese and non-obese participants. Also, a significant difference was noted between obese and non-obese in tissue remodeling biomarker MMP9 (p<0.03).
+
+ CONCLUSIONS: A surge in the level of the biomarkers, i.e., MMP9, leptin, and adiponectin in the gingival crevicular fluid is found in obese undergoing fixed orthodontic treatment.
+Registry Number/Name of Substance
+ 0 (Leptin). EC 3-4-24-34 (Matrix Metalloproteinase 8). EC 3-4-24-35 (Matrix Metalloproteinase 9). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.26355%2feurrev_202303_31532
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alqerban&issn=1128-3602&title=European+Review+for+Medical+%26+Pharmacological+Sciences&atitle=Effect+of+ten+different+biomarkers+in+the+gingival+crevicular+fluid+of+obese+and+non-obese+undergoing+fixed+orthodontic+treatment.&volume=27&issue=5&spage=1722&epage=1728&date=2023&doi=10.26355%2Feurrev_202303_31532&pmid=36930468&sid=OVID:medline
+
+<288>
+Unique Identifier
+ 36911663
+Title
+ Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies. [Review]
+Source
+ Frontiers in Immunology. 14:1098570, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li Z; Gao Z; Sun T; Zhang S; Yang S; Zheng M; Shen H
+Authors Full Name
+ Li, Zhuoqi; Gao, Ziyu; Sun, Tao; Zhang, Shipeng; Yang, Shengnan; Zheng, Meilin; Shen, Hui.
+Institution
+ Li, Zhuoqi. Department of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, China.
+ Gao, Ziyu. Department of Thyroid Surgery, The First Hospital of China Medical University, China Medical University, Shen Yang, China.
+ Sun, Tao. Department of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, China.
+ Zhang, Shipeng. Department of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, China.
+ Yang, Shengnan. Department of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, China.
+ Zheng, Meilin. Department of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, China.
+ Shen, Hui. Department of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, China.
+MeSH Subject Headings
+ Animals
+ Humans
+ *Inflammation
+ *Adipokines
+ Nerve Growth Factors/me [Metabolism]
+ Obesity
+ Biomarkers
+Keyword Heading
+ Metrnl
+ bone
+ diabetes
+ heart
+ immunity
+ inflammation
+ metabolism
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Meteorin-like, also known as Metrnl, Meteorin-beta, Subfatin, and Cometin, is a novel secreted protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier research on this hormone focused on regulating energy expenditure and glucose homeostasis. Consequently, several studies attempted to characterize the molecule mechanism of Metrnl in glucose metabolism and obesity-related disorders but reported contradictory clinical results. Recent studies gradually noticed its multiple protective functions in inflammatory immune regulations and cardiometabolic diseases, such as inducing macrophage activation, angiogenesis, tissue remodeling, bone formation, and preventing dyslipidemias. A comprehensive understanding of this novel protein is essential to identify its significance as a potential therapeutic drug or a biomarker of certain diseases. In this review, we present the current knowledge on the physiology of Metrnl and its roles in inflammation, immunology, and metabolism, including animal/cell interventional preclinical studies and human clinical studies. We also describe controversies regarding the data of circulation Metrnl in different disease states to determine its clinical application better. Copyright © 2023 Li, Gao, Sun, Zhang, Yang, Zheng and Shen.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Nerve Growth Factors). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3389%2ffimmu.2023.1098570
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Meteorin-like%2FMetrnl%2C+a+novel+secreted+protein+implicated+in+inflammation%2C+immunology%2C+and+metabolism%3A+A+comprehensive+review+of+preclinical+and+clinical+studies.&volume=14&issue=&spage=1098570&epage=&date=2023&doi=10.3389%2Ffimmu.2023.1098570&pmid=36911663&sid=OVID:medline
+
+<289>
+Unique Identifier
+ 36902288
+Title
+ Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease. [Review]
+Source
+ International Journal of Molecular Sciences. 24(5), 2023 Mar 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pekkala S
+Authors Full Name
+ Pekkala, Satu.
+Institution
+ Pekkala, Satu. Faculty of Sport and Health Sciences, University of Jyvaskyla, 40014 Jyvaskyla, Finland.
+ Pekkala, Satu. Institute of Biomedicine, Medical Microbiology and Immunology, University of Turku, 20014 Turku, Finland.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Diet, High-Fat
+ Liver/me [Metabolism]
+ Obesity/me [Metabolism]
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ NAFLD
+ diet
+ gut microbiota
+ liver fat
+ metabolic pathways
+ metabolomics
+ metagenomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The frequency of non-alcoholic fatty liver disease (NAFLD) has intensified, creating diagnostic challenges and increasing the need for reliable non-invasive diagnostic tools. Due to the importance of the gut-liver axis in the progression of NAFLD, studies attempt to reveal microbial signatures in NAFLD, evaluate them as diagnostic biomarkers, and to predict disease progression. The gut microbiome affects human physiology by processing the ingested food into bioactive metabolites. These molecules can penetrate the portal vein and the liver to promote or prevent hepatic fat accumulation. Here, the findings of human fecal metagenomic and metabolomic studies relating to NAFLD are reviewed. The studies present mostly distinct, and even contradictory, findings regarding microbial metabolites and functional genes in NAFLD. The most abundantly reproducing microbial biomarkers include increased lipopolysaccharides and peptidoglycan biosynthesis, enhanced degradation of lysine, increased levels of branched chain amino acids, as well as altered lipid and carbohydrate metabolism. Among other causes, the discrepancies between the studies may be related to the obesity status of the patients and the severity of NAFLD. In none of the studies, except for one, was diet considered, although it is an important factor driving gut microbiota metabolism. Future studies should consider diet in these analyses.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fijms24054855
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pekkala&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Fecal+Metagenomics+and+Metabolomics+Identifying+Microbial+Signatures+in+Non-Alcoholic+Fatty+Liver+Disease.&volume=24&issue=5&spage=&epage=&date=2023&doi=10.3390%2Fijms24054855&pmid=36902288&sid=OVID:medline
+
+<290>
+Unique Identifier
+ 36900791
+Title
+ The Mediating Effect of Central Obesity on the Association between Dietary Quality, Dietary Inflammation Level and Low-Grade Inflammation-Related Serum Inflammatory Markers in Adults.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 20(5), 2023 02 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang S; Yang X; E L; Zhang X; Chen H; Jiang X
+Author NameID
+ Zhang, Shuai; ORCID: https://orcid.org/0000-0002-5059-6688
+Authors Full Name
+ Zhang, Shuai; Yang, Xuebin; E, Limei; Zhang, Xiaofei; Chen, Hongru; Jiang, Xiubo.
+Institution
+ Zhang, Shuai. Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266021, China.
+ Yang, Xuebin. Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266021, China.
+ E, Limei. Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266021, China.
+ Zhang, Xiaofei. Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266021, China.
+ Chen, Hongru. Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266021, China.
+ Jiang, Xiubo. Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266021, China.
+MeSH Subject Headings
+ Adult
+ Humans
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Nutrition Surveys
+ *Obesity, Abdominal
+ Cross-Sectional Studies
+ Diet
+ Inflammation
+ Biomarkers
+ Obesity
+Keyword Heading
+ CRP
+ diet quality
+ dietary score
+ inflammatory marker
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ To date, few studies have explored the role of central obesity on the association between diet quality, measured by the health eating index (HEI), inflammatory eating index (DII), and low-grade inflammation-related serum inflammatory markers. In this paper, we use the data from the 2015-2018 National Health and Nutrition Examination Survey (NHANES) to explore this. Dietary intakes were measured during two 24-h dietary recall interviews and using USDA Food Pattern Equivalence Database (FPED) dietary data. Serum inflammatory markers were obtained from NHANES Laboratory Data. Generalized structural equation models (GSEMs) were used to explore the mediating relationship. Central obesity plays a significant mediating role in the association between HEI-2015 and high-sensitivity C-reactive protein (hs-CRP), mediating 26.87% of the associations between the two; it also mediates 15.24% of the associations between DII and hs-CRP. Central obesity plays a mediating role in 13.98% of the associations between HEI-2015 and white blood cells (WBC); it also mediates 10.83% of the associations between DII and WBC. Our study suggests that central obesity plays a mediating role in the association of dietary quality with low-grade inflammation-related serum inflammatory markers (hs-CRP and WBC).
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fijerph20053781
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=The+Mediating+Effect+of+Central+Obesity+on+the+Association+between+Dietary+Quality%2C+Dietary+Inflammation+Level+and+Low-Grade+Inflammation-Related+Serum+Inflammatory+Markers+in+Adults.&volume=20&issue=5&spage=&epage=&date=2023&doi=10.3390%2Fijerph20053781&pmid=36900791&sid=OVID:medline
+
+<291>
+Unique Identifier
+ 36866796
+Title
+ Application of Fourier transform infrared spectroscopy to detect biochemical changes in blood serum of obese patients.
+Source
+ Journal of Biophotonics. 16(6):e202200388, 2023 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Guleken Z; Cecen S; Ceylan Z; Jakubczyk P; Depciuch J
+Author NameID
+ Guleken, Zozan; ORCID: https://orcid.org/0000-0002-4136-4447
+Authors Full Name
+ Guleken, Zozan; Cecen, Serpil; Ceylan, Zeynep; Jakubczyk, Pawel; Depciuch, Joanna.
+Institution
+ Guleken, Zozan. Gaziantep University of Islam Science and Technology, Faculty of Medicine, Department of Physiology, Gaziantep, Turkey.
+ Cecen, Serpil. Health Science University, Hamidiye Faculty of Medicine, Department of Physiology, Istanbul, Turkey.
+ Ceylan, Zeynep. Faculty of Engineering, Department of Industrial Engineering, Samsun University, Samsun, Turkey.
+ Jakubczyk, Pawel. Institute of Physics, University of Rzeszow, Rzeszow, Poland.
+ Depciuch, Joanna. Department of Functional Nanomaterials, Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland.
+ Depciuch, Joanna. Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland.
+MeSH Subject Headings
+ Humans
+ Spectroscopy, Fourier Transform Infrared/mt [Methods]
+ *Serum
+ Triglycerides
+ *Obesity
+ Biomarkers
+Keyword Heading
+ Fourier transform infrared spectroscopy
+ anthropometric
+ chemometric method
+ lipid profile
+ obesity
+ principal component analysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is frequently a significant risk factor for multiple obesity-associated diseases that have been increasing in prevalence worldwide. Anthropometric data such as body mass index, fat, and fat mass values are assessed for obesity. Therefore, we aimed to propose two Fourier transform infrared (FT-IR) spectral regions, 800-1800 cm-1 and 2700-3000 cm-1 , as sensitive potential band assignments for obesity-related biochemical changes. A total of 134 obese (n = 89) and controls (n = 45) biochemical characteristics and clinical parameters indicative of obesity were evaluated. The FT-IR spectra of dried blood serum were measured. Anthropometric data of the obese have the highest body mass index, %fat, and fat mass values compared to the healthy group (p < 0.01). Also, the triglyceride and high-density lipoprotein cholesterol levels were higher than in healthy subjects (p < 0.01). Principal component analysis (PCA) technique successfully distinguished obese and control groups in the fingerprint, accounting for 98.5% and 99.9% of the total variability (800-1800 cm-1 ) and lipids (2700-3000 cm-1 ) regions presented as 2D and 3D score plots. The loading results indicated that peaks corresponding to phosphonate groups, glucose, amide I, and lipid groups were shifted in the obese group, indicating their potential as biomarkers of obesity. This study suggests that FTIR analysis based on PCA can provide a detailed and reliable method for the analysis of blood serum in obese patients. Copyright © 2023 Wiley-VCH GmbH.
+Registry Number/Name of Substance
+ 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2fjbio.202200388
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Guleken&issn=1864-063X&title=Journal+of+Biophotonics&atitle=Application+of+Fourier+transform+infrared+spectroscopy+to+detect+biochemical+changes+in+blood+serum+of+obese+patients.&volume=16&issue=6&spage=e202200388&epage=&date=2023&doi=10.1002%2Fjbio.202200388&pmid=36866796&sid=OVID:medline
+
+<292>
+Unique Identifier
+ 36859451
+Title
+ Different correlation of body mass index with body fatness and obesity-related biomarker according to age, sex and race-ethnicity.
+Source
+ Scientific Reports. 13(1):3472, 2023 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jeong SM; Lee DH; Rezende LFM; Giovannucci EL
+Authors Full Name
+ Jeong, Su-Min; Lee, Dong Hoon; Rezende, Leandro F M; Giovannucci, Edward L.
+Institution
+ Jeong, Su-Min. Department of Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
+ Jeong, Su-Min. Department of Family Medicine, Seoul National University Health Service Center, Seoul, Republic of Korea.
+ Jeong, Su-Min. Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
+ Lee, Dong Hoon. Department of Sport Industry Studies, Yonsei University, Seoul, Republic of Korea.
+ Lee, Dong Hoon. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
+ Rezende, Leandro F M. Department of Preventive Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
+ Giovannucci, Edward L. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. egiovann@hsph.harvard.edu.
+ Giovannucci, Edward L. Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Bldg. 2, Room 371, Boston, MA, 02115, USA. egiovann@hsph.harvard.edu.
+MeSH Subject Headings
+ Female
+ Humans
+ Male
+ *Adipose Tissue
+ Biomarkers
+ Body Mass Index
+ *Ethnicity
+ Nutrition Surveys
+ Obesity/eh [Ethnology]
+ *Obesity
+ Republic of Korea
+Abstract
+ The relationship between body mass index (BMI) and body fatness could differ according to age, sex, and race-ethnicity. We aimed to evaluate in which contexts BMI could be a good measure for body fatness compared to dual-energy X-ray absorptiometry (DXA) derived measures. The study population included 18,061 participants (9141 men and 8920 women) aged 18 and older who tested DXA from the National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2006, and 8107 men and 10,754 women with DXA data from Korea NHANES from 2008 to 2011 to represent the Asian population. We calculated Pearson correlation coefficients between BMI and DXA derived fat mass index (FMI) and percentage body fat (PBF) depending on age, sex, and race-ethnicity. The correlation between BMI, FMI and PBF and obesity-related biomarkers was also estimated among the subgroup with both DXA and information on each biomarker. BMI was strongly correlated with FMI (r = 0.944 in men and 0.976 in women), PBF (r = 0.735 in men and 0.799 in women), and truncal fat mass (r = 0.914 in men and 0.941 in women) with correlations stronger in women than in men except for with waist-height ratio (r = 0.921 in men and 0.911 in women). The correlation between BMI and DXA derived adiposity weakened with age in both sexes. BMI was less correlated with FMI (r = 0.840 in men and 0.912 in women), PBF (r = 0.645 in men and 0.681 in women), and truncal fat mass (r = 0.836 in men and 0.884 in women) in Korean compared to other race-ethnicities. Among obesity-related biomarkers, insulin was the most strongly correlated to body adiposity indices in both sexes and strength of these correlations generally decreased with age. BMI predicted obesity-related biomarkers as well as FMI and truncal fat mass and superior to PBF. BMI could be a good measure for body fatness, particularly among young age groups, women, the US population, but less so in Korean populations. The lower correlation between BMI and body fatness in older compared to younger age groups could be related to increasing PBF and decreasing lean body mass. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1038%2fs41598-023-30527-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jeong&issn=2045-2322&title=Scientific+Reports&atitle=Different+correlation+of+body+mass+index+with+body+fatness+and+obesity-related+biomarker+according+to+age%2C+sex+and+race-ethnicity.&volume=13&issue=1&spage=3472&epage=&date=2023&doi=10.1038%2Fs41598-023-30527-w&pmid=36859451&sid=OVID:medline
+
+<293>
+Unique Identifier
+ 36822523
+Title
+ Exposure to serum perfluoroalkyl substances and biomarkers of liver function: The Korean national environmental health survey 2015-2017.
+Source
+ Chemosphere. 322:138208, 2023 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim OJ; Kim S; Park EY; Oh JK; Jung SK; Park S; Hong S; Jeon HL; Kim HJ; Park B; Park B; Kim S; Kim B
+Authors Full Name
+ Kim, Ok-Jin; Kim, Seyoung; Park, Eun Young; Oh, Jin Kyoung; Jung, Sun Kyoung; Park, Soyoung; Hong, Sooyeon; Jeon, Hye Li; Kim, Hyun-Jin; Park, Bohyun; Park, Bomi; Kim, Suejin; Kim, Byungmi.
+Institution
+ Kim, Ok-Jin. Environmental Health Research Department, National Institute of Environmental Research, Incheon, 22689, Republic of Korea.
+ Kim, Seyoung. National Cancer Control Institute, National Cancer Center, Goyang, 10408, Republic of Korea.
+ Park, Eun Young. Department of Preventive Medicine, College of Medicine, Korea University, Seoul, 02841, Republic of Korea.
+ Oh, Jin Kyoung. National Cancer Control Institute, National Cancer Center, Goyang, 10408, Republic of Korea; Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, 10408, Republic of Korea.
+ Jung, Sun Kyoung. Environmental Health Research Department, National Institute of Environmental Research, Incheon, 22689, Republic of Korea.
+ Park, Soyoung. Environmental Health Research Department, National Institute of Environmental Research, Incheon, 22689, Republic of Korea.
+ Hong, Sooyeon. Environmental Health Research Department, National Institute of Environmental Research, Incheon, 22689, Republic of Korea.
+ Jeon, Hye Li. Environmental Health Research Department, National Institute of Environmental Research, Incheon, 22689, Republic of Korea.
+ Kim, Hyun-Jin. National Cancer Control Institute, National Cancer Center, Goyang, 10408, Republic of Korea; Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, 10408, Republic of Korea.
+ Park, Bohyun. National Cancer Control Institute, National Cancer Center, Goyang, 10408, Republic of Korea.
+ Park, Bomi. Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, 06974, Republic of Korea.
+ Kim, Suejin. Environmental Health Research Department, National Institute of Environmental Research, Incheon, 22689, Republic of Korea. Electronic address: suenier@korea.kr.
+ Kim, Byungmi. National Cancer Control Institute, National Cancer Center, Goyang, 10408, Republic of Korea; Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, 10408, Republic of Korea. Electronic address: kbm5369@ncc.re.kr.
+MeSH Subject Headings
+ Male
+ Adult
+ Humans
+ Female
+ *Environmental Pollutants
+ Bayes Theorem
+ Fluorocarbons/to [Toxicity]
+ *Fluorocarbons
+ Obesity
+ Biomarkers
+ Alanine Transaminase
+ Environmental Health
+ Liver
+ Republic of Korea
+ *Alkanesulfonic Acids
+ Environmental Exposure
+Keyword Heading
+ Environmental chemicals
+ Liver enzymes
+ Mixture analyses
+ Perfluoroalkyl substances (PFAS)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Exposure to perfluoroalkyl substances (PFAS) may increase the risk of liver disease by disrupting cholesterol and lipid synthesis/metabolism, leading to higher liver-enzyme concentrations. However, most studies assessing association between PFAS and liver enzymes focused on individual PFAS. Moreover, PFAS concentrations differ based on sex and obesity status, and it remains unclear whether these factors affect associations with liver function. Therefore, we examined the association between exposure to both individual and combined PFAS and liver-function biomarkers and assessed sex and obesity as effect modifiers in Korean adults.
+
+ METHODS: We measured serum concentrations of the five most abundant PFAS (PFOA, PFOS, PFHxS, PFDA, PFNA) and three liver enzymes (alanine transaminase [ALT], aspartate aminotransferase [AST], gamma-glutamyl transferase [GGT]) in 1404 adults from the Korean National Environmental Health Survey Cycle 3, 2015-2017. We used linear regression to evaluate associations between individual PFAS and liver-function biomarkers, assessing sex and obesity as possible effect modifiers, and performed Bayesian kernel machine regression and quantile g-computation to evaluate the overall effect of PFAS mixture on biomarkers of liver function.
+
+ RESULTS: Among 1404 Korean adults, all five PFAS were detected. Geometric mean concentration was highest for PFOS (16.11 mug/L), followed by PFOA (5.83 mug/L), PFHxS (2.21 mug/L), PFNA (2.03 mug/L), and PFDA (1.06 mug/L). In multivariable linear regression, all PFAS were positively associated with ALT, AST, and GGT; 2-fold increase in each PFAS was associated with 3.4-8.6% higher ALT, 2.4-4.6% higher AST, and 4.6-11.1% higher GGT (all p < 0.05). Positive associations for PFOA, PFDA, and PFNA with AST were stronger in men, and positive associations for PFOS with ALT and GGT were stronger in women. Compared to obese participants, nonobese participants had higher average percent changes in each enzyme, particularly GGT, when individual PFAS concentration doubled. Additionally, increased exposure to PFAS mixtures was associated with higher ALT, AST, and GGT. In quantile g-computations, simultaneous quartile increase in all PFAS was significantly associated with 6.9% (95%CI: 3.7, 10.2) higher ALT, 4.5% (95%CI: 2.4, 6.6) higher AST, and 8.3% (95%CI: 3.7, 13.1) higher GGT levels, on average.
+
+ CONCLUSIONS: Exposure to individual and combined PFAS is associated with higher liver enzymes in Korean adults, providing additional evidence for the association between PFAS exposure and risk of liver disease. Copyright © 2023. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Environmental Pollutants). 0 (Fluorocarbons). 0 (Biomarkers). EC 2-6-1-2 (Alanine Transaminase). 0 (Alkanesulfonic Acids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.chemosphere.2023.138208
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=0045-6535&title=Chemosphere&atitle=Exposure+to+serum+perfluoroalkyl+substances+and+biomarkers+of+liver+function%3A+The+Korean+national+environmental+health+survey+2015-2017.&volume=322&issue=&spage=138208&epage=&date=2023&doi=10.1016%2Fj.chemosphere.2023.138208&pmid=36822523&sid=OVID:medline
+
+<294>
+Unique Identifier
+ 36787445
+Title
+ Nonalcoholic Fatty Liver Disease Severity Is Related to Plasma Pro-Oxidative Biomarkers Rather Than Liver Tissue-Measured Nitrogen Metabolism Biomarkers in Population with Obesity and Metabolic Syndrome.
+Source
+ Metabolic Syndrome & Related Disorders. 21(2):115-121, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Suarez-Cuenca JA; Dominguez-Perez GA; Hernandez-Munoz RE; Hernandez-Patricio A; Vera-Gomez E; Gutierrez-Buendia JA; Salamanca-Garcia M; Montoya-Ramirez J; Gaytan-Fuentes OF; Aranda-Rodriguez C; Rojas-Noveron AR; Garcia S; Mondragon-Teran P
+Author NameID
+ Suarez-Cuenca, Juan Antonio; ORCID: https://orcid.org/0000-0002-2098-5658
+Authors Full Name
+ Suarez-Cuenca, Juan Antonio; Dominguez-Perez, Gabriela A; Hernandez-Munoz, Rolando E; Hernandez-Patricio, Alejandro; Vera-Gomez, Eduardo; Gutierrez-Buendia, Juan A; Salamanca-Garcia, Moises; Montoya-Ramirez, Jesus; Gaytan-Fuentes, Omar F; Aranda-Rodriguez, Carolina; Rojas-Noveron, Amy R; Garcia, Silvia; Mondragon-Teran, Paul.
+Institution
+ Suarez-Cuenca, Juan Antonio. Laboratory of Experimental Metabolism and Clinical Research, Centro Medico Nacional, "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Suarez-Cuenca, Juan Antonio. Division de Investigacion, Department of Clinical Research, Centro Medico Nacional "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Suarez-Cuenca, Juan Antonio. Hospital General de Zona No. 32 "Dr. Mario Madrazo Navarro," IMSS, Mexico City, Mexico.
+ Dominguez-Perez, Gabriela A. Laboratory of Experimental Metabolism and Clinical Research, Centro Medico Nacional, "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Hernandez-Munoz, Rolando E. Cellular and Developmental Biology Department, Institute of Cellular Phyosiology, UNAM, Ciudad Universitaria, Mexico City, Mexico.
+ Hernandez-Patricio, Alejandro. Laboratory of Experimental Metabolism and Clinical Research, Centro Medico Nacional, "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Vera-Gomez, Eduardo. Laboratory of Experimental Metabolism and Clinical Research, Centro Medico Nacional, "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Gutierrez-Buendia, Juan A. Laboratory of Experimental Metabolism and Clinical Research, Centro Medico Nacional, "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Salamanca-Garcia, Moises. Department of Pathology, Centro Medico Nacional "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Montoya-Ramirez, Jesus. Department of Bariatric Surgery, Centro Medico Nacional "20 de Noviembre," ISSSTE, Mexico City, Mexico.
+ Gaytan-Fuentes, Omar F. Department of Bariatric Surgery, Centro Medico Nacional "20 de Noviembre," ISSSTE, Mexico City, Mexico.
+ Aranda-Rodriguez, Carolina. Laboratory of Experimental Metabolism and Clinical Research, Centro Medico Nacional, "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Rojas-Noveron, Amy R. Laboratory of Experimental Metabolism and Clinical Research, Centro Medico Nacional, "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Garcia, Silvia. Division de Investigacion, Department of Clinical Research, Centro Medico Nacional "20 de Noviembre" ISSSTE, Mexico City, Mexico.
+ Mondragon-Teran, Paul. Research Coordination, Centro Medico Nacional "20 de Noviembre," ISSSTE, Mexico City, Mexico.
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Non-alcoholic Fatty Liver Disease
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome
+ Cross-Sectional Studies
+ Obesity/ep [Epidemiology]
+ Biomarkers
+ Hypertension/co [Complications]
+ *Hypertension
+ Oxidation-Reduction
+ Oxidative Stress
+Keyword Heading
+ NAFLD progression
+ metabolic syndrome
+ nitrogen metabolism
+ obesity
+ pro-oxidative biomarkers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: The metabolic syndrome (MS) is associated with an increased production of nitrogen metabolites and elevated oxidative stress, which favors progression of nonalcoholic fatty liver disease (NAFLD). Subjects with the phenotype known as metabolically unhealthy obese (MUO) meet most of the MS cardiometabolic risk criteria and show a higher risk of advanced NAFLD severity, compared with the so-widely known metabolically healthy obese (MHO). Obese individuals with MS are more susceptible to abnormal lipid accumulation in different tissues, whereas oxidative stress and nitrogen metabolites are increased in MS and/or obesity. This study aimed to explore whether plasma- or liver tissue-determined biomarkers of nitrogen metabolism and oxidative stress relate to NAFLD severity and/or metabolic phenotype. Methods: This cross-sectional study included candidates for bariatric surgery with biopsy-proven NAFLD diagnosis and staging. For comparison, the study population was divided according to NAFLD damage (steatohepatitis F0-F1 vs. steatohepatitis F2-F4) and metabolic phenotype (MHO vs MUO, based on the MS criteria). Hepatic and plasma concentrations of nitrogen metabolites and oxidative stress biomarkers were determined by enzymatic kinetics assays, enzyme-linked immunosorbent assay, and Greiss reaction. Results: The study population (N = 45) was constituted by patients with obesity and higher prevalence of dyslipidemia, diabetes mellitus, and hypertension. According to plasma biomarkers, MUO phenotype was related to higher cardiometabolic risk; meanwhile, advanced NAFLD damage was related to higher glycated hemoglobin (HbA1c) and triglycerides. Elevated hepatic concentrations of ammonium, nitrites, arginine, and citrulline were found in MUO phenotype, but only higher plasma concentration of malondialdehyde was found as specifically related to advanced NAFLD damage. Conclusions: Circulating biomarkers of redox state were selectively related to advanced NAFLD damage, suggesting prognostic and therapeutic targets. Hepatic concentrations of nitrogen metabolism biomarkers may be more related to cardiometabolic risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1089%2fmet.2022.0007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Suarez-Cuenca&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Nonalcoholic+Fatty+Liver+Disease+Severity+Is+Related+to+Plasma+Pro-Oxidative+Biomarkers+Rather+Than+Liver+Tissue-Measured+Nitrogen+Metabolism+Biomarkers+in+Population+with+Obesity+and+Metabolic+Syndrome.&volume=21&issue=2&spage=115&epage=121&date=2023&doi=10.1089%2Fmet.2022.0007&pmid=36787445&sid=OVID:medline
+
+<295>
+Unique Identifier
+ 36774491
+Title
+ Markers for obese and non-obese Type 2 diabetes identified using whole blood metabolomics.
+Source
+ Scientific Reports. 13(1):2460, 2023 02 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Teruya T; Sunagawa S; Mori A; Masuzaki H; Yanagida M
+Authors Full Name
+ Teruya, Takayuki; Sunagawa, Sumito; Mori, Ayaka; Masuzaki, Hiroaki; Yanagida, Mitsuhiro.
+Institution
+ Teruya, Takayuki. G0 Cell Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa, Japan.
+ Teruya, Takayuki. R&D Cluster Programs Section, Technology Development and Innovation Center, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa, Japan.
+ Sunagawa, Sumito. Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
+ Mori, Ayaka. G0 Cell Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa, Japan.
+ Mori, Ayaka. Cell Division Dynamics Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa, Japan.
+ Masuzaki, Hiroaki. Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
+ Yanagida, Mitsuhiro. G0 Cell Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa, Japan. myanagid@gmail.com.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Glycated Hemoglobin
+ Biomarkers
+ Metabolomics
+ Obesity/me [Metabolism]
+Abstract
+ Definitive differences in blood metabolite profiles between obese and non-obese Type 2 diabetes (T2D) have not been established. We performed an LC-MS-based non-targeted metabolomic analysis of whole blood samples collected from subjects classified into 4 types, based on the presence or absence of obesity and T2D. Of the 125 compounds identified, 20, comprising mainly nucleobases and glucose metabolites, showed significant increases or decreases in the T2D group. These included cytidine, UDP-glucuronate, UMP, 6-phosphogluconate, and pentose-phosphate. Among those 20 compounds, 11 enriched in red blood cells (RBCs) have rarely been studied in the context of diabetes, indicating that RBC metabolism is more extensively disrupted than previously known. Correlation analysis revealed that these T2D markers include 15 HbA1c-associated and 5 irrelevant compounds that may reflect diabetic conditions by a different mechanism than that of HbA1c. In the obese group, enhanced protein and fatty acid catabolism causes increases in 13 compounds, including methylated or acetylated amino acids and short-chain carnitines. Our study, which may be considered a pilot investigation, suggests that changes in blood metabolism due to obesity and diabetes are large, but essentially independent. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Glycated Hemoglobin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1038%2fs41598-023-29619-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Teruya&issn=2045-2322&title=Scientific+Reports&atitle=Markers+for+obese+and+non-obese+Type+2+diabetes+identified+using+whole+blood+metabolomics.&volume=13&issue=1&spage=2460&epage=&date=2023&doi=10.1038%2Fs41598-023-29619-4&pmid=36774491&sid=OVID:medline
+
+<296>
+Unique Identifier
+ 36771387
+Title
+ Dark Sweet Cherry (Prunus avium) Supplementation Reduced Blood Pressure and Pro-Inflammatory Interferon Gamma (IFNgamma) in Obese Adults without Affecting Lipid Profile, Glucose Levels and Liver Enzymes.
+Source
+ Nutrients. 15(3), 2023 Jan 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Arbizu S; Mertens-Talcott SU; Talcott S; Noratto GD
+Author NameID
+ Noratto, Giuliana D; ORCID: https://orcid.org/0000-0003-1831-7172
+Authors Full Name
+ Arbizu, Shirley; Mertens-Talcott, Susanne U; Talcott, Stephen; Noratto, Giuliana D.
+Institution
+ Arbizu, Shirley. Department of Food Science and Technology, Texas A&M University, College Station, TX 77843, USA.
+ Mertens-Talcott, Susanne U. Department of Food Science and Technology, Texas A&M University, College Station, TX 77843, USA.
+ Talcott, Stephen. Department of Food Science and Technology, Texas A&M University, College Station, TX 77843, USA.
+ Noratto, Giuliana D. Department of Food Science and Technology, Texas A&M University, College Station, TX 77843, USA.
+MeSH Subject Headings
+ Humans
+ Adult
+ *Prunus avium
+ Interferon-gamma/pd [Pharmacology]
+ Blood Pressure
+ Single-Blind Method
+ Obesity
+ Inflammation
+ Dietary Supplements
+ Biomarkers
+ Liver
+ Glucose/pd [Pharmacology]
+ Lipids
+Keyword Heading
+ clinical study
+ dark sweet cherries
+ inflammation
+ metabolic disorders
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Dark sweet cherries (DSC) are rich in fiber and polyphenols that decrease risk factors associated with obesity. This single-blind randomized placebo-controlled study investigated DSC effects on inflammation, cardiometabolic, and liver health biomarkers in obese adults. Participants (>18 years, body mass index (BMI) = 30-40 kg/m2) consumed 200 mL of DSC drink (juice supplemented with DSC powder) (n = 19) or a placebo drink (n = 21) twice/day for 30 days. Anthropometric and physiological biomarkers were monitored at baseline (D1), mid-point (D15), and endpoint (D30) visits. Blood inflammatory biomarkers were assessed at D1, D15, and D30, and blood lipids, glucose, and liver enzymes at D1 and D30. DSC consumption lowered systolic blood pressure (SBP) (p = 0.05) and decreased diastolic blood pressure (DBP) compared to placebo (p = 0.04). Stratification of participants by BMI revealed a greater (p = 0.008) SBP reduction in BMI > 35 participants. DSC lowered pro-inflammatory interferon-gamma (IFNgamma) (p = 0.001), which correlated with SBP changes. The interleukin (IL)-1RA and SBP changes were correlated in the placebo group, as well as triglycerides (TG) with DBP. The increased IL-10 levels in the placebo group suggested a compensatory mechanism to counteract elevated IFNgamma levels. No significant between-group differences were detected for blood lipids, glucose, and liver enzymes. In conclusion, DSC helped to decrease blood pressure levels and inflammation in obese adults.
+Registry Number/Name of Substance
+ 82115-62-6 (Interferon-gamma). 0 (Biomarkers). IY9XDZ35W2 (Glucose). 0 (Lipids).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fnu15030681
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Arbizu&issn=2072-6643&title=Nutrients&atitle=Dark+Sweet+Cherry+%28Prunus+avium%29+Supplementation+Reduced+Blood+Pressure+and+Pro-Inflammatory+Interferon+Gamma+%28IFNgamma%29+in+Obese+Adults+without+Affecting+Lipid+Profile%2C+Glucose+Levels+and+Liver+Enzymes.&volume=15&issue=3&spage=&epage=&date=2023&doi=10.3390%2Fnu15030681&pmid=36771387&sid=OVID:medline
+
+<297>
+Unique Identifier
+ 36771263
+Title
+ Triglyceride-Glucose Index as a Potential Indicator of Sarcopenic Obesity in Older People.
+Source
+ Nutrients. 15(3), 2023 Jan 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim B; Kim G; Lee Y; Taniguchi K; Isobe T; Oh S
+Author NameID
+ Kim, Bokun; ORCID: https://orcid.org/0000-0001-9553-3368
+ Kim, Gwonmin; ORCID: https://orcid.org/0000-0001-7901-3506
+Authors Full Name
+ Kim, Bokun; Kim, Gwonmin; Lee, Yongkook; Taniguchi, Keisuke; Isobe, Tomonori; Oh, Sechang.
+Institution
+ Kim, Bokun. Department of Anti-Ageing Health Care, Changwon National University, Changwon 51140, Republic of Korea.
+ Kim, Bokun. Future Convergence Research Institute, Changwon National University, Changwon 51140, Republic of Korea.
+ Kim, Gwonmin. Medical Research Institute, Pusan National University, Busan 46241, Republic of Korea.
+ Lee, Yongkook. Department of Leisure Sports, Seoil University, Seoul 02192, Republic of Korea.
+ Taniguchi, Keisuke. Department of Physical Therapy, AHRU Medical Care and Welfare Professional Training College, Tsuchiura 300-0032, Japan.
+ Isobe, Tomonori. Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
+ Oh, Sechang. Faculty of Rehabilitation, R Professional University of Rehabilitation, Tsuchiura 300-0032, Japan.
+MeSH Subject Headings
+ Male
+ Female
+ Humans
+ Aged
+ Glucose
+ Sarcopenia/di [Diagnosis]
+ Sarcopenia/ep [Epidemiology]
+ *Sarcopenia
+ Triglycerides
+ Risk Factors
+ Cross-Sectional Studies
+ Blood Glucose
+ *Insulin Resistance
+ Obesity/co [Complications]
+ Biomarkers
+Keyword Heading
+ TyG index
+ insulin resistance
+ obesity
+ older population
+ sarcopenia
+ sarcopenic obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: This population-based cross-sectional study aimed to determine whether the triglyceride-glucose index (TyG index) is associated with sarcopenic obesity (SO) and whether it would be a helpful indicator of SO.
+
+ METHODS: A total of 3821 participants aged >= 60 years were selected for the study group, and 4919 participants aged 20-39 years were included as a reference group. The participants were allocated to sarcopenia, obesity, and SO groups depending on if their body mass index (BMI) was >=25 kg/m2 and their sarcopenia index was <=1 standard deviation (SD) lower than the mean of the reference group. The sex-specific differences and trends among the participants were analyzed by using the TyG index tertiles, and appropriate cut-off values of the TyG index for SO were calculated.
+
+ RESULTS: As the TyG index increased, BMI increased, but the sarcopenia index decreased in both sexes. Males and females in the middle and highest tertiles of the TyG index were 1.775 and 3.369, and they were 1.993 and 3.157 times more likely to have SO, respectively. The cut-off values of the TyG index for SO in males and females were >=8.72 and 8.67, respectively.
+
+ CONCLUSION: A high TyG index is positively associated with SO, and the TyG index may be considered a potential indicator of SO.
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fnu15030555
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=2072-6643&title=Nutrients&atitle=Triglyceride-Glucose+Index+as+a+Potential+Indicator+of+Sarcopenic+Obesity+in+Older+People.&volume=15&issue=3&spage=&epage=&date=2023&doi=10.3390%2Fnu15030555&pmid=36771263&sid=OVID:medline
+
+<298>
+Unique Identifier
+ 36754448
+Title
+ Stratification Of LIver Disease (SOLID): protocol for a prospective observational cohort study to determine the optimum biomarker strategies for the detection of advanced liver disease at the primary-secondary care interface.
+Source
+ BMJ Open Gastroenterology. 10(1), 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ McPherson S; Jarvis H; McGonigle J; Bedlington J; Dean J; Hallsworth K; Hanon E; Liddle T; Luvai A; Mansour D; Patel P; Renwick L; Teare D; Tanney C; Anstee Q
+Author NameID
+ McPherson, Stuart; ORCID: https://orcid.org/0000-0002-5638-2453
+ Mansour, Dina; ORCID: https://orcid.org/0000-0002-8367-4232
+ Anstee, Quentin; ORCID: https://orcid.org/0000-0002-9518-0088
+Authors Full Name
+ McPherson, Stuart; Jarvis, Helen; McGonigle, John; Bedlington, Joan; Dean, Jill; Hallsworth, Kate; Hanon, Elodie; Liddle, Trevor; Luvai, Ahai; Mansour, Dina; Patel, Preya; Renwick, Laura; Teare, Dawn; Tanney, Christina; Anstee, Quentin.
+Institution
+ McPherson, Stuart. Liver Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK stuart.mcpherson2@nhs.net.
+ McPherson, Stuart. Translational & Clinical Research Institute, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
+ McPherson, Stuart. Newcastle NIHR Biomedical Research Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+ Jarvis, Helen. Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
+ McGonigle, John. Cruddas Park and Hillsview Surgery, Newcastle upon Tyne, UK.
+ Bedlington, Joan. LIVErNORTH Charity, Newcastle upon Tyne, UK.
+ Dean, Jill. Clinical Research Network North East and Cumbria, Newcastle upon Tyne, UK.
+ Hallsworth, Kate. Liver Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+ Hallsworth, Kate. Translational & Clinical Research Institute, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
+ Hallsworth, Kate. Newcastle NIHR Biomedical Research Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+ Hanon, Elodie. Department of Blood Sciences, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+ Liddle, Trevor. Clinical Research Informatics, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+ Luvai, Ahai. Department of Blood Sciences, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+ Mansour, Dina. Translational & Clinical Research Institute, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
+ Mansour, Dina. Gastrointestinal and Liver Services, Gateshead Health NHS Foundation Trust, Gateshead, UK.
+ Patel, Preya. Liver Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+ Renwick, Laura. Clinical Research Network North East and Cumbria, Newcastle upon Tyne, UK.
+ Teare, Dawn. Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
+ Tanney, Christina. Clinical Research Network North East and Cumbria, Newcastle upon Tyne, UK.
+ Anstee, Quentin. Liver Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+ Anstee, Quentin. Translational & Clinical Research Institute, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
+ Anstee, Quentin. Newcastle NIHR Biomedical Research Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
+MeSH Subject Headings
+ Humans
+ Prospective Studies
+ Secondary Care
+ *Diabetes Mellitus, Type 2
+ Complement C3
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/ep [Epidemiology]
+ Liver Cirrhosis/co [Complications]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Biomarkers
+ Obesity/co [Complications]
+ Observational Studies as Topic
+Keyword Heading
+ alcohol
+ cirrhosis
+ diabetes mellitus
+ fatty liver
+ primary care
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Undiagnosed fatty liver disease is prevalent in the community, due to high rates of harmful alcohol consumption and/or obesity. Fatty liver disease can progress to cirrhosis and its complications. Early identification of liver disease and treatment may prevent progression to cirrhosis. Biomarkers including FIB-4, enhanced liver fibrosis (ELF), PRO-C3 and vibration controlled transient elastography (VCTE) can stage liver fibrosis, but it is not known how well they perform in a primary care population. Moreover, no assessment of long-term prognostic ability of these biomarkers has been conducted in primary care. We aim to evaluate the performance of fibrosis biomarkers in primary care to develop a pathway to detect advanced fibrosis.
+
+ METHODS AND ANALYSIS: This prospective, observational cohort study will recruit 3000 individuals with fatty liver disease risk factors (obesity, type 2 diabetes or hazardous alcohol consumption) at their primary care 'annual chronic disease review'. Participants will have a 'liver health check'. Two pathways will be evaluated: (1) all have FIB-4, ELF and VCTE performed, and (2) patients have an initial assessment with FIB-4 and ELF, followed by VCTE in only those with increased FIB-4 and/or ELF. Individuals with suspected significant/advanced liver fibrosis (liver stiffness measurement>8 kPa), will be reviewed in secondary care to confirm their fibrosis stage and institute treatment. The performance of FIB-4, ELF, PRO-C3, VCTE and novel biomarkers alone or in combination for advanced fibrosis/cirrhosis will be evaluated. Participants will be followed longitudinally via their electronic health records to assess long-term clinical outcomes.
+
+ ETHICS AND DISSEMINATION: Ethical approval was obtained from the London-Chelsea Research Ethics Committee (22/PR/0535; 27 June 2022). Recruitment began on 31 October 2022. Outcomes of this study will be published in peer-reviewed journals and presented at scientific meetings. A lay summary of the results will be available for study participants and will be disseminated widely by LIVErNORTH. Copyright © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Complement C3). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1136%2fbmjgast-2022-001092
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=McPherson&issn=2054-4774&title=BMJ+Open+Gastroenterology&atitle=Stratification+Of+LIver+Disease+%28SOLID%29%3A+protocol+for+a+prospective+observational+cohort+study+to+determine+the+optimum+biomarker+strategies+for+the+detection+of+advanced+liver+disease+at+the+primary-secondary+care+interface.&volume=10&issue=1&spage=&epage=&date=2023&doi=10.1136%2Fbmjgast-2022-001092&pmid=36754448&sid=OVID:medline
+
+<299>
+Unique Identifier
+ 36752775
+Title
+ L-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial.
+Source
+ Food & Function. 14(4):2172-2187, 2023 Feb 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fallah F; Mahdavi R
+Author NameID
+ Fallah, Farnoush; ORCID: http://orcid.org/0000-0002-9930-2871
+ Mahdavi, Reza; ORCID: http://orcid.org/0000-0002-5444-2395
+Authors Full Name
+ Fallah, Farnoush; Mahdavi, Reza.
+Institution
+ Fallah, Farnoush. Student Research Committee, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. fallahfarnoush@gmail.com.
+ Mahdavi, Reza. Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. mahdavirez@hotmail.com.
+MeSH Subject Headings
+ Humans
+ Female
+ *Synbiotics
+ Carnitine/tu [Therapeutic Use]
+ Interleukin-10
+ Tartrates
+ Tumor Necrosis Factor-alpha
+ *Endotoxemia
+ Biomarkers
+ Inflammation/dt [Drug Therapy]
+ Dietary Supplements
+ C-Reactive Protein/me [Metabolism]
+ Obesity/dt [Drug Therapy]
+ Anti-Inflammatory Agents
+ Interleukin-6
+ Double-Blind Method
+Abstract
+ Obesity, a chronic pandemic disease, is characterized by low-grade chronic inflammation, accompanied by over-expression of pro-inflammatory cytokines, thereby contributing to metabolic disorders pathogenesis. Oxidative-stress, an adverse cellular response to adipocyte hypertrophy, promotes inflammation. Furthermore, gut-microbiota dysbiosis may induce oxidative-stress, low-grade inflammation, and metabolic-endotoxemia as major drivers of obesity. Functional-foods/nutraceuticals have attracted extensive attention due to their plausible anti-inflammatory/anti-oxidative properties; evidence supports the superiority of the nutraceutical combined-supplementation approach versus conventional mono-therapies. Current data suggest the anti-oxidative/anti-inflammatory properties of either L-carnitine or pre/pro/synbiotics. This trial compared the effects of co-supplementing L-carnitine and multi-species/multi-strain synbiotic versusL-carnitine mono-therapy on inflammatory/anti-inflammatory, oxidative-stress, and metabolic-endotoxemia biomarkers in 46 female obese patients, receiving either co-supplementation (L-carnitine-tartrate (2 x 500 mg d-1) + multi-species/multi-strain synbiotic (1 capsule per day)) or mono-therapy (L-carnitine-tartrate (2 x 500 mg d-1) + maltodextrin (1 capsule per day)) for eight weeks. L-Carnitine + synbiotic co-supplementation significantly decreased interleukin-6 (IL-6, -33.98%), high-sensitivity-C-reactive-protein (hs-CRP, -10%), tumor-necrosis-factor-alpha (TNF-alpha, -18.73%), malondialdehyde (MDA, -21.73%), and lipopolysaccharide (LPS, -10.14%), whereas the increase in interleukin-10 (IL-10, 7.69%) and total-antioxidant-capacity (TAC, 4.13%) levels was not significant. No significant changes were observed for the above-mentioned parameters in the L-carnitine + placebo group, except for a significant reduction in IL-10 (-17.59%) and TNF-alpha (-14.78%); however, between-group differences did not reach the significant threshold. Co-supplementing L-carnitine + multi-strain synbiotic led to significant amelioration of inflammatory, oxidative, and metabolic-endotoxemia responses in female obese patients; nevertheless, no improving effects were observed in patients receiving single-supplementation, suggesting that L-carnitine + synbiotic co-supplementation might represent an adjuvant approach to improve oxidative-stress/pro-inflammatory indicators in women with obesity, possibly through beneficial effects of the synbiotic alone. Further longer duration studies with higher doses of L-carnitine in a three-group setting are warranted to elucidate the possibility of synergistic or complementary mechanisms.
+Registry Number/Name of Substance
+ S7UI8SM58A (Carnitine). 130068-27-8 (Interleukin-10). 0 (Tartrates). 0 (Tumor Necrosis Factor-alpha). 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). 0 (Anti-Inflammatory Agents). 0 (Interleukin-6).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1039%2fd2fo03348h
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fallah&issn=2042-6496&title=Food+%26+Function&atitle=L-Carnitine+and+synbiotic+co-supplementation%3A+beneficial+effects+on+metabolic-endotoxemia%2C+meta-inflammation%2C+and+oxidative-stress+biomarkers+in+obese+patients%3A+a+double+blind%2C+randomized%2C+controlled+clinical+trial.&volume=14&issue=4&spage=2172&epage=2187&date=2023&doi=10.1039%2Fd2fo03348h&pmid=36752775&sid=OVID:medline
+
+<300>
+Unique Identifier
+ 36736061
+Title
+ Association between maternal obesity, essential fatty acids and biomarkers of fetal liver function.
+Source
+ Prostaglandins Leukotrienes & Essential Fatty Acids. 190:102541, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ortiz M; Sanchez F; Alvarez D; Flores C; Salas-Perez F; Valenzuela R; Cantin C; Leiva A; Crisosto N; Maliqueo M
+Authors Full Name
+ Ortiz, Macarena; Sanchez, Francisca; Alvarez, Daniela; Flores, Cristian; Salas-Perez, Francisca; Valenzuela, Rodrigo; Cantin, Claudette; Leiva, Andrea; Crisosto, Nicolas; Maliqueo, Manuel.
+Institution
+ Ortiz, Macarena. Laboratory of Endocrinology and Metabolism, Department of Medicine West Division, Universidad de Chile, Santiago, Chile.
+ Sanchez, Francisca. Laboratory of Endocrinology and Metabolism, Department of Medicine West Division, Universidad de Chile, Santiago, Chile.
+ Alvarez, Daniela. Laboratory of Endocrinology and Metabolism, Department of Medicine West Division, Universidad de Chile, Santiago, Chile.
+ Flores, Cristian. Laboratory of Endocrinology and Metabolism, Department of Medicine West Division, Universidad de Chile, Santiago, Chile.
+ Salas-Perez, Francisca. Institute of Health Sciences, Universidad de O'higgins, Rancagua, Chile.
+ Valenzuela, Rodrigo. Nutrition Department, School of Medicine, Universidad de Chile, Santiago, Chile.
+ Cantin, Claudette. School of Medical Technology, Faculty of Medicine and Science, Universidad San Sebastian, Santiago, Chile.
+ Leiva, Andrea. School of Medical Technology, Faculty of Medicine and Science, Universidad San Sebastian, Santiago, Chile.
+ Crisosto, Nicolas. Laboratory of Endocrinology and Metabolism, Department of Medicine West Division, Universidad de Chile, Santiago, Chile; Endocrinology Unit, Department of Medicine, Clinica Alemana de Santiago, Faculty of Medicine, Universidad del Desarrollo, Santiago, Chile.
+ Maliqueo, Manuel. Laboratory of Endocrinology and Metabolism, Department of Medicine West Division, Universidad de Chile, Santiago, Chile. Electronic address: mmaliqueo@uchile.cl.
+MeSH Subject Headings
+ Infant, Newborn
+ Humans
+ Female
+ Pregnancy
+ *Obesity, Maternal
+ alpha-Linolenic Acid
+ Fatty Acids
+ Fatty Acids, Essential
+ Obesity
+ Linoleic Acid
+ Fetal Blood
+ Liver
+ Biomarkers
+Keyword Heading
+ Alpha-linolenic acid
+ Gamma-glutamyl transferase
+ Linoleic acid
+ Non-alcoholic fatty liver disease
+ Obesity
+ Very low-density lipoprotein
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Maternal obesity and the imbalance in linoleic acid (C18:2 n-6, LA) and alpha-linolenic acid (C18:3 n-3, ALA) levels are related with hepatic disturbances in the offspring. However, whether these alterations are present during fetal life is not well understood. Obese and normal weight pregnant women were recruited to determine fatty acids (FAs) consumption, FAs profile (in maternal erythrocytes, placenta and neonatal very low-density lipoproteins VLDL) and biomarkers of fetal liver function, such as gamma-glutamyl transferase (GGT), alpha-fetoprotein (AFP) and albumin, in umbilical cord blood. Stearic acid (C18:0, ST) was lower, and total n-3 FAs tended to be lower in umbilical cord VLDLs of obese women compared to controls. Independently of maternal obesity, GGT levels in umbilical cord blood was positively correlated with the LA content and negatively correlated with the ALA content in maternal erythrocytes. We conclude that maternal obesity and its imbalance of LA and ALA are associated with changes in biomarkers of fetal liver function. Copyright © 2023 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0RBV727H71 (alpha-Linolenic Acid). 0 (Fatty Acids). 0 (Fatty Acids, Essential). 9KJL21T0QJ (Linoleic Acid). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.plefa.2023.102541
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ortiz&issn=0952-3278&title=Prostaglandins+Leukotrienes+%26+Essential+Fatty+Acids&atitle=Association+between+maternal+obesity%2C+essential+fatty+acids+and+biomarkers+of+fetal+liver+function.&volume=190&issue=&spage=102541&epage=&date=2023&doi=10.1016%2Fj.plefa.2023.102541&pmid=36736061&sid=OVID:medline
+
+<301>
+Unique Identifier
+ 36735151
+Title
+ Age-adjusted reference values and influencing factors of cystatin C in healthy Chinese population.
+Source
+ International Urology & Nephrology. 55(6):1641-1644, 2023 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ji M; Fu Y; Wan X; Du X
+Author NameID
+ Du, Xin; ORCID: http://orcid.org/0000-0002-9536-6595
+Authors Full Name
+ Ji, Ming; Fu, Yongchao; Wan, Xinglin; Du, Xin.
+Institution
+ Ji, Ming. Department of Health Management Center, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
+ Fu, Yongchao. Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
+ Wan, Xinglin. Department of Health Management Center, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
+ Du, Xin. Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Chang Le Road 68, Nanjing, 210006, China. duxin@njmu.edu.cn.
+MeSH Subject Headings
+ Adult
+ Female
+ Humans
+ Male
+ Biomarkers
+ *Cystatin C
+ *East Asian People
+ Obesity/ep [Epidemiology]
+ Prospective Studies
+ Reference Values
+Keyword Heading
+ Cystatin C
+ Reference values
+ Risk factors
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Normative distribution of serum cystatin C and relationship with sex and age in healthy adult Chinese population is unknown.
+
+ METHODS: This is a prospective cohort study. Adult subjects (18 years of age and older) who underwent annual health examination at the Health Management Center in Sir Run Run Hospital were eligible. Subjects with major diseases, e.g., hypertension, diabetes, chronic kidney disease, obesity (body mass index >= 28 kg/m2) were excluded from the analysis. Multivariate logistic regression analysis was conducted to identify risk factors of elevated cystatin C (> 1.03 mg/L). Data are shown as median and 95% confidence interval (CI).
+
+ RESULTS: The final analysis included a total of 10,640 subjects (40 +/- 12 years, 52% men). The median serum cystatin C concentration was 0.73 mg/L (95% CI 0.52-1.03 mg/L) in the overall analysis, 0.79 (95% CI 0.59-1.07 mg/L) in men, and 0.67 (95% CI 0.49-0.95 mg/L) in women. In the multivariate regression analysis, elevated cystatin C was independently associated with the male sex (odds ratio 1.94; 95% CI 1.07-3.52), older age (odds ratio 1.04 every year; 95% CI 1.02-1.06), higher body mass index (odds ratio 1.70; 95% CI 1.01-2.83), uric acid (odds ratio 1.00; 95% CI 1.00-1.01), and beta2-microglobulin (odds ratio 39.35; 95% CI 22.90-67.64).
+
+ CONCLUSION: The median serum cystatin C concentration was 0.73 (95% CI 0.52-1.03 mg/L) in healthy adult Chinese population, 0.79 (95% CI 0.59-1.07 mg/L) in men, and 0.67 (95% CI 0.49-0.95 mg/L) in women. Elevated cystatin C was associated with the male sex, older age and higher body mass index. Copyright © 2023. The Author(s), under exclusive licence to Springer Nature B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cystatin C).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs11255-023-03497-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ji&issn=0301-1623&title=International+Urology+%26+Nephrology&atitle=Age-adjusted+reference+values+and+influencing+factors+of+cystatin+C+in+healthy+Chinese+population.&volume=55&issue=6&spage=1641&epage=1644&date=2023&doi=10.1007%2Fs11255-023-03497-1&pmid=36735151&sid=OVID:medline
+
+<302>
+Unique Identifier
+ 36717394
+Title
+ Multi-omics approaches for precision obesity management : Potentials and limitations of omics in precision prevention, treatment and risk reduction of obesity. [Review]
+Source
+ Wiener Klinische Wochenschrift. 135(5-6):113-124, 2023 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Woldemariam S; Dorner TE; Wiesinger T; Stein KV
+Author NameID
+ Stein, Katharina Viktoria; ORCID: http://orcid.org/0000-0002-6225-6226
+Authors Full Name
+ Woldemariam, Selam; Dorner, Thomas E; Wiesinger, Thomas; Stein, Katharina Viktoria.
+Institution
+ Woldemariam, Selam. Karl Landsteiner Institute for Health Promotion Research, 3062, Kirchstetten, Austria.
+ Dorner, Thomas E. Karl Landsteiner Institute for Health Promotion Research, 3062, Kirchstetten, Austria.
+ Dorner, Thomas E. Academy for Ageing Research, House of Mercy, 1160, Vienna, Austria.
+ Wiesinger, Thomas. Karl Landsteiner Institute for Health Promotion Research, 3062, Kirchstetten, Austria.
+ Stein, Katharina Viktoria. Karl Landsteiner Institute for Health Promotion Research, 3062, Kirchstetten, Austria. k.v.stein@lumc.nl.
+ Stein, Katharina Viktoria. Department of Public Health and Primary Care, Leiden University Medical Centre, 2511 DP, The Hague, The Netherlands. k.v.stein@lumc.nl.
+MeSH Subject Headings
+ Humans
+ *Multiomics
+ *Obesity Management
+ Genome-Wide Association Study
+ Biomarkers
+ Obesity/ge [Genetics]
+ Obesity/pc [Prevention & Control]
+Keyword Heading
+ Health promotion
+ Metabolomics
+ Microbiomics
+ Multi-omics
+ Precision obesity prevention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity is a multifactorial chronic disease that cannot be addressed by simply promoting better diets and more physical activity. To date, not a single country has successfully been able to curb the accumulating burden of obesity. One explanation for the lack of progress is that lifestyle intervention programs are traditionally implemented without a comprehensive evaluation of an individual's diagnostic biomarkers. Evidence from genome-wide association studies highlight the importance of genetic and epigenetic factors in the development of obesity and how they in turn affect the transcriptome, metabolites, microbiomes, and proteomes.
+
+ OBJECTIVE: The purpose of this review is to provide an overview of the different types of omics data: genomics, epigenomics, transcriptomics, proteomics, metabolomics and illustrate how a multi-omics approach can be fundamental for the implementation of precision obesity management.
+
+ RESULTS: The different types of omics designs are grouped into two categories, the genotype approach and the phenotype approach. When applied to obesity prevention and management, each omics type could potentially help to detect specific biomarkers in people with risk profiles and guide healthcare professionals and decision makers in developing individualized treatment plans according to the needs of the individual before the onset of obesity.
+
+ CONCLUSION: Integrating multi-omics approaches will enable a paradigm shift from the one size fits all approach towards precision obesity management, i.e. (1) precision prevention of the onset of obesity, (2) precision medicine and tailored treatment of obesity, and (3) precision risk reduction and prevention of secondary diseases related to obesity. Copyright © 2023. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs00508-022-02146-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Woldemariam&issn=0043-5325&title=Wiener+Klinische+Wochenschrift&atitle=Multi-omics+approaches+for+precision+obesity+management+%3A+Potentials+and+limitations+of+omics+in+precision+prevention%2C+treatment+and+risk+reduction+of+obesity.&volume=135&issue=5-6&spage=113&epage=124&date=2023&doi=10.1007%2Fs00508-022-02146-4&pmid=36717394&sid=OVID:medline
+
+<303>
+Unique Identifier
+ 36716820
+Title
+ Food addiction, hormones and blood biomarkers in humans: A systematic literature review. [Review]
+Source
+ Appetite. 183:106475, 2023 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Romer SS; Bliokas V; Teo JT; Thomas SJ
+Authors Full Name
+ Romer, Stephanie Sophie; Bliokas, Vida; Teo, Jillian Terese; Thomas, Susan J.
+Institution
+ Romer, Stephanie Sophie. School of Psychology, Faculty of the Arts, Social Sciences and Humanities, University of Wollongong, Australia. Electronic address: ssr932@uowmail.edu.au.
+ Bliokas, Vida. School of Psychology, Faculty of the Arts, Social Sciences and Humanities, University of Wollongong, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, 2522, Australia. Electronic address: vida@uow.edu.au.
+ Teo, Jillian Terese. School of Psychology, Faculty of the Arts, Social Sciences and Humanities, University of Wollongong, Australia. Electronic address: jtt268@uowmail.edu.au.
+ Thomas, Susan J. Illawarra Health and Medical Research Institute, University of Wollongong, 2522, Australia; Graduate School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Australia. Electronic address: sthomas@uow.edu.au.
+MeSH Subject Headings
+ Animals
+ Humans
+ *Food Addiction
+ Obesity/px [Psychology]
+ Behavior, Addictive/px [Psychology]
+ *Behavior, Addictive
+ Cholecystokinin
+ Biomarkers
+ Feeding Behavior/px [Psychology]
+Abstract
+ BACKGROUND: Food addiction may play a role in rising obesity rates in connection with obesogenic environments and processed food availability, however the concept of food addiction remains controversial. While animal studies show evidence for addictive processes in relation to processed foods, most human studies are psychologically focussed and there is a need to better understand evidence for biological mechanisms of food addiction in humans. Several key hormones are implicated in models of food addiction, due to their key roles in feeding, energy metabolism, stress and addictive behaviours. This systematic literature review examines evidence for relationships between food addiction, hormones and other blood biomarkers.
+
+ METHODS: A series of literature searches was performed in Scopus, PsychInfo, MedLine, ProQuest, CINAHL and Web of Science. A total of 3111 articles were found, of which 1045 were duplicates. Articles were included if they contained a psychometric measurement of food addiction, such as the Yale Food Addiction Scale, as well as addressed the association between FA and hormones or blood biomarkers in humans. Articles were assessed for eligibility by two independent reviewers.
+
+ RESULTS: Sixteen studies were identified that examined relationships between food addiction and blood biomarkers, published between 2015 and 2021. Significant findings were reported for leptin, ghrelin, cortisol, insulin and glucose, oxytocin, cholesterol, plasma dopamine, thyroid stimulating hormone (TSH), haemoglobin A1c (HbA1c), triglyceride (TG), amylin, tumour necrosis factor alpha (TNF- alpha) and cholecystokinin (CCK). Methodological issues included small sample sizes and variation in obesity status, sex and mental health-related comorbidities. Due to methodological limitations, definite connections between FA, hormones and other blood biomarkers cannot yet be determined.
+
+ CONCLUSION: This systematic review identified preliminary evidence linking FA symptoms to hormones and other blood biomarkers related to feeding, addiction, and stress. However, due to the small number of studies and methodological limitations, further research is needed to evaluate biopsychosocial models of FA and to resolve controversies. Copyright © 2023 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 9011-97-6 (Cholecystokinin). 0 (Biomarkers).
+Publication Type
+ Systematic Review. Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.appet.2023.106475
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Romer&issn=0195-6663&title=Appetite&atitle=Food+addiction%2C+hormones+and+blood+biomarkers+in+humans%3A+A+systematic+literature+review.&volume=183&issue=&spage=106475&epage=&date=2023&doi=10.1016%2Fj.appet.2023.106475&pmid=36716820&sid=OVID:medline
+
+<304>
+Unique Identifier
+ 36710112
+Title
+ Effectiveness of Ramadan diurnal intermittent fasting and concurrent training in the management of obesity: is the combination worth the weight?.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 33(3):659-666, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Maaloul R; Marzougui H; Ben Dhia I; Ghroubi S; Tagougui S; Kallel C; Driss T; Elleuch MH; Ayadi F; Turki M; Hammouda O
+Authors Full Name
+ Maaloul, Rami; Marzougui, Houssem; Ben Dhia, Imen; Ghroubi, Sameh; Tagougui, Semah; Kallel, Choumous; Driss, Tarak; Elleuch, Mohamed Habib; Ayadi, Fatma; Turki, Mouna; Hammouda, Omar.
+Institution
+ Maaloul, Rami. High Institute of Sport and Physical Education of Sfax, University of Sfax, Tunisia; Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Tunisia.
+ Marzougui, Houssem. High Institute of Sport and Physical Education of Sfax, University of Sfax, Tunisia; Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Tunisia.
+ Ben Dhia, Imen. High Institute of Sport and Physical Education of Sfax, University of Sfax, Tunisia; Research Laboratory of Evaluation and Management of Musculoskeletal System Pathologies, LR20ES09, University of Sfax, Tunisia.
+ Ghroubi, Sameh. Research Laboratory of Evaluation and Management of Musculoskeletal System Pathologies, LR20ES09, University of Sfax, Tunisia.
+ Tagougui, Semah. Montreal Clinical Research Institute, Montreal, Canada; Universite de Lille, Universite d'Artois, Universite du Littoral Cote d'Opale, ULR 7369-URePSSS-Unite de Recherche Pluridisciplinaire Sport Sante Societe, Lille, France.
+ Kallel, Choumous. Hematology laboratory, CHU Habib Bourguiba, Sfax, Tunisia.
+ Driss, Tarak. Interdisciplinary Laboratory in Neurosciences, Physiology and Psychology: Physical Activity, Health and Learning (LINP2), UFR STAPS, UPL, Paris Nanterre, Nanterre, France.
+ Elleuch, Mohamed Habib. Research Laboratory of Evaluation and Management of Musculoskeletal System Pathologies, LR20ES09, University of Sfax, Tunisia.
+ Ayadi, Fatma. Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Tunisia.
+ Turki, Mouna. Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Tunisia.
+ Hammouda, Omar. Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Tunisia; Interdisciplinary Laboratory in Neurosciences, Physiology and Psychology: Physical Activity, Health and Learning (LINP2), UFR STAPS, UPL, Paris Nanterre, Nanterre, France. Electronic address: hammouda.o@parisnanterre.fr.
+MeSH Subject Headings
+ Male
+ Humans
+ Young Adult
+ Adult
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose
+ *Intermittent Fasting
+ Obesity/di [Diagnosis]
+ Obesity/th [Therapy]
+ Body Composition
+ Lipids
+ Biomarkers/me [Metabolism]
+ Inflammation/di [Diagnosis]
+Keyword Heading
+ Concurrent exercise training
+ HIIT
+ Intermittent fasting
+ Obesity
+ Time restricted eating
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: We investigated, in men with obesity, the efficacy of the combination of two strategies (Ramadan diurnal intermittent fasting 'RDIF' strategy vs RDIF plus concurrent training program 'RDIF-CT' strategy) known for their positive impact on body composition and then we explored the possible impact on metabolic and inflammatory biomarkers.
+
+ METHODS AND RESULTS: Twenty obese men, age: 31.8 +/- 7.05 years, BMI: 33.1 +/- 4.2 kg m-2, performing regularly RDIF, were randomized into two groups: RDIF-CT (n = 10) and RDIF without training (RDIF-NCT) (n = 10). The RDIF-CT group participated in High intensity interval training (HIIT) program combined with resistance exercises for 4 weeks. Body composition, blood glucose, lipid profile, liver biomarkers and inflammation were assessed before and after 4-week RDIF. Both groups showed a significant decrease in weight, fat mass (FM), fat percentage (Fat%) and waist circumference (WC) and an improvement in blood glucose, lipid profile and inflammation. Fat free mass decreased significantly in RDIF-NCT (p < 0.05) while remaining unchanged in RDIF-CT. However, RDIF-CT induced greater improvements in body composition (i.e., weight, FM, Fat% and WC (p < 0.05, p < 0.01, p < 0.01 and p < 0.05; respectively)) as well as greater decrease in lipid biomarkers (i.e., TC, TG and LDL (p < 0.01 for all)), inflammation (i.e., CRP (p < 0.05)), and liver damage (i.e., ASAT, ALAT and Gamma-GT (p < 0.01, p < 0.05 and p < 0.001; respectively)) compared to RDIF-NCT group pre-post intervention.
+
+ CONCLUSIONS: Our results suggest that a combination of RDIF and CT induces greater changes in body composition, lipid profile, inflammation and liver biomarkers compared to RDIF strategy alone.
+
+ CLINICAL TRIAL REGISTER: PACTR202203475387226. Copyright © 2022. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Blood Glucose). 0 (Lipids). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.numecd.2022.12.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Maaloul&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Effectiveness+of+Ramadan+diurnal+intermittent+fasting+and+concurrent+training+in+the+management+of+obesity%3A+is+the+combination+worth+the+weight%3F.&volume=33&issue=3&spage=659&epage=666&date=2023&doi=10.1016%2Fj.numecd.2022.12.004&pmid=36710112&sid=OVID:medline
+
+<305>
+Unique Identifier
+ 36707969
+Title
+ Are Phosphatidylcholine and Lysophosphatidylcholine Body Levels Potentially Reliable Biomarkers in Obesity? A Review of Human Studies. [Review]
+Source
+ Molecular Nutrition & Food Research. 67(7):e2200568, 2023 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bellot PENR; Moia MN; Reis BZ; Pedrosa LFC; Tasic L; Barbosa F Jr; Sena-Evangelista KCM
+Author NameID
+ Reis, Bruna Zavarize; ORCID: https://orcid.org/0000-0001-8726-8699
+ Pedrosa, Lucia Fatima Campos; ORCID: https://orcid.org/0000-0002-5436-5115
+ Tasic, Ljubica; ORCID: https://orcid.org/0000-0003-2930-7332
+ Sena-Evangelista, Karine Cavalcanti Mauricio; ORCID: https://orcid.org/0000-0001-9729-1243
+Authors Full Name
+ Bellot, Paula Emilia Nunes Ribeiro; Moia, Melissa Nunes; Reis, Bruna Zavarize; Pedrosa, Lucia Fatima Campos; Tasic, Ljubica; Barbosa, Fernando Jr; Sena-Evangelista, Karine Cavalcanti Mauricio.
+Institution
+ Bellot, Paula Emilia Nunes Ribeiro. Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-970, Natal, Rio Grande do Norte, Brazil.
+ Moia, Melissa Nunes. Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-970, Natal, Rio Grande do Norte, Brazil.
+ Reis, Bruna Zavarize. Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-970, Natal, Rio Grande do Norte, Brazil.
+ Reis, Bruna Zavarize. Department of Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-970, Natal, Rio Grande do Norte, Brazil.
+ Pedrosa, Lucia Fatima Campos. Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-970, Natal, Rio Grande do Norte, Brazil.
+ Pedrosa, Lucia Fatima Campos. Department of Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-970, Natal, Rio Grande do Norte, Brazil.
+ Tasic, Ljubica. Department of Organic Chemistry, Institute of Chemistry, University of Campinas, Campinas, Rua Josue de Castro s/n - Cidade Universitaria Zeferino Vaz, 13083-970, Campinas, Sao Paulo-SP, Brazil.
+ Barbosa, Fernando Jr. Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Ribeirao Preto Campus, Av. do Cafe, s/n - Monte Alegre, 14040-903, Ribeirao Preto, Sao Paulo-SP, Brazil.
+ Sena-Evangelista, Karine Cavalcanti Mauricio. Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-970, Natal, Rio Grande do Norte, Brazil.
+ Sena-Evangelista, Karine Cavalcanti Mauricio. Department of Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-970, Natal, Rio Grande do Norte, Brazil.
+MeSH Subject Headings
+ Humans
+ Animals
+ *Lysophosphatidylcholines
+ *Phosphatidylcholines
+ Obesity
+ Lecithins
+ Biomarkers
+ Lipidomics
+ Inflammation
+Keyword Heading
+ acyl-alkyl-lysophosphatidylcholines
+ acyl-alkylphosphatidylcholine
+ adiposity
+ diacyl-phosphatidylcholine
+ lipidomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Phosphatidylcholines (PCs) are the major components of biological membranes in animals and are a class of phospholipids that incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are a class of lipid biomolecules derived from the cleavage of PCs, and are the main components of oxidized low-density lipoproteins (oxLDLs) that are involved in the pathogenesis of atherosclerosis. Since obesity is associated with a state of chronic low-grade inflammation, one can anticipate that the lipidomic profile changes in this context and both PCs and LPCs are gaining attention as hypothetically reliable biomarkers of obesity. Thus, a literature search is performed on PubMed, Latin American and Caribbean Health Science Literature (LILACS), and Excerpta Medica DataBASE (Embase) to obtain the findings of population studies to clarify this hypothesis. The search strategy resulted in a total of 2403 reports and 21 studies were included according to the eligibility criteria. Controversial data on the associations of PCs and LPCs with body mass index (BMI) and body fat parameters have been identified. There is an inverse relationship between BMI and most species of PCs, and a majority of studies exhibited negative associations between BMI and LPCs. Other findings regarding the differences between PCs and LPCs in obesity are presented, and the associated uncertainties are discussed in detail. Copyright © 2023 Wiley-VCH GmbH.
+Registry Number/Name of Substance
+ 0 (Lysophosphatidylcholines). 0 (Phosphatidylcholines). 0 (Lecithins). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2fmnfr.202200568
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bellot&issn=1613-4125&title=Molecular+Nutrition+%26+Food+Research&atitle=Are+Phosphatidylcholine+and+Lysophosphatidylcholine+Body+Levels+Potentially+Reliable+Biomarkers+in+Obesity%3F+A+Review+of+Human+Studies.&volume=67&issue=7&spage=e2200568&epage=&date=2023&doi=10.1002%2Fmnfr.202200568&pmid=36707969&sid=OVID:medline
+
+<306>
+Unique Identifier
+ 36706764
+Title
+ Resistance Band Exercise: An Effective Strategy to Reverse Cardiometabolic Disorders in Women With Osteosarcopenic Obesity.
+Source
+ Journal of Aging & Physical Activity. 31(4):633-641, 2023 08 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Banitalebi E; Banitalebi E; Ghahfarokhi MM; Rahimi M; Laher I; Davison K
+Author NameID
+ Banitalebi, Ebrahim; ORCID: https://orcid.org/0000-0002-9943-9747
+ Ghahfarokhi, Majid Mardaniyan; ORCID: https://orcid.org/0000-0002-5933-3913
+ Rahimi, Mostafa; ORCID: https://orcid.org/0000-0002-1592-2601
+ Laher, Ismail; ORCID: https://orcid.org/0000-0002-3917-4417
+ Davison, Kade; ORCID: https://orcid.org/0000-0002-7101-7729
+Authors Full Name
+ Banitalebi, Ebrahim; Banitalebi, Elahe; Ghahfarokhi, Majid Mardaniyan; Rahimi, Mostafa; Laher, Ismail; Davison, Kade.
+Institution
+ Banitalebi, Ebrahim. Department of Sport Sciences, Shahrekord University, Shahrekord,Iran.
+ Banitalebi, Elahe. Department of Sport Sciences, Shahrekord University, Shahrekord,Iran.
+ Ghahfarokhi, Majid Mardaniyan. Department of Sport Sciences, Shahrekord University, Shahrekord,Iran.
+ Rahimi, Mostafa. Department of Sport Sciences, Shahrekord University, Shahrekord,Iran.
+ Laher, Ismail. Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, Vancouver, BC,Canada.
+ Davison, Kade. Department of Allied Health & Human Performance, Alliance for Research in Exercise, Nutrition and Activity, University of South Australia: Allied Health and Human Performance, Adelaide, SA,Australia.
+MeSH Subject Headings
+ Aged
+ Female
+ Humans
+ Biomarkers
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Exercise
+ Exercise Therapy
+ Obesity/th [Therapy]
+ *Obesity
+ Aged, 80 and over
+Keyword Heading
+ body composition/exercise training
+ cardiometabolic/obesity indices
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We designed to evaluate the effects of resistance elastic band exercises (REBEs) on cardiometabolic/obesity-related biomarkers in older females with osteosarcopenic obesity. Sixty-three patients (aged 65-80 years) with osteosarcopenic obesity and a body mass index exceeding 30 kg/m2 were enrolled in the study. The participants were randomly assigned to either an experimental group (REBE, n = 32) or a usual care group (n = 31). The experimental group completed a 12-week REBE program, three times a week and 60 min per session. There were decreases in lipid accumulation product (p = .033), visceral adipose index (p = .001), triglyceride-glucose-body mass index (p = .034), and atherogenic index of plasma (p = .028) in the experimental group compared with the usual care group. Our findings highlight the importance of an REBE program in improving combined cardiometabolic/obesity-related indices in older women with osteosarcopenic obesity. The incorporation of an REBE program may benefit individuals who are unable to tolerate or participate in more strenuous exercise programs.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1123%2fjapa.2022-0241
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Banitalebi&issn=1063-8652&title=Journal+of+Aging+%26+Physical+Activity&atitle=Resistance+Band+Exercise%3A+An+Effective+Strategy+to+Reverse+Cardiometabolic+Disorders+in+Women+With+Osteosarcopenic+Obesity.&volume=31&issue=4&spage=633&epage=641&date=2023&doi=10.1123%2Fjapa.2022-0241&pmid=36706764&sid=OVID:medline
+
+<307>
+Unique Identifier
+ 36696640
+Title
+ Blood biomarkers for new-onset hypertension in midlife women: a nested case-control study.
+Source
+ Menopause. 30(2):156-164, 2023 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ He Z; Yang P; Lin Q; Thio CHL; Zhang F; Wang R; Wang Y; Snieder H; Zhang Q
+Authors Full Name
+ He, Zhen; Yang, Peixuan; Lin, Qiuqiang; Thio, Chris H L; Zhang, Fan; Wang, Ruifeng; Wang, Yue; Snieder, Harold; Zhang, Qingying.
+Institution
+ Yang, Peixuan. Department of Physical Examination, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
+ Lin, Qiuqiang. Department of Internal Medicine, Chenghai People's Hospital, Shantou, China.
+ Thio, Chris H L. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
+ Wang, Ruifeng. Department of Physical Examination, Chenghai People's Hospital, Shantou, China.
+ Wang, Yue. From the Department of Public Health and Preventive Medicine, Shantou University Medical College, Shantou, China.
+ Snieder, Harold. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
+ Zhang, Qingying. From the Department of Public Health and Preventive Medicine, Shantou University Medical College, Shantou, China.
+MeSH Subject Headings
+ Middle Aged
+ Humans
+ Female
+ Case-Control Studies
+ *Hypertension
+ Blood Pressure/ph [Physiology]
+ Risk Factors
+ Obesity/co [Complications]
+ Biomarkers
+Abstract
+ OBJECTIVE: Midlife in women is associated with an increase in prevalence of hypertension. Little is known on the risk factors of new-onset hypertension among middle-aged women.
+
+ METHODS: In this nested case-control study, 1,430 women aged 40 to 60 years with repeated physical examinations between 2009 and 2019 were recruited. Data included age, body mass index, blood pressure (BP), and a series of blood biomarkers. Participants with hypertension were divided into two case-control samples: 388 cases with episodic new-onset hypertension (ie, one normal BP at the first visit and one abnormal BP during follow-up) each with two age-matched controls (n = 776) and 151 cases with regular new-onset hypertension (ie, normal BP at the first two visits and abnormal BP at two or more follow-up visits) each with three age-matched controls (n = 453). Multivariable-adjusted logistic regression was used to analyze the data.
+
+ RESULTS: Our data showed very consistent results for episodic and regular new-onset hypertension, respectively, and verified known associations (odds ratio [95% confidence interval], per SD increase) with obesity (body mass index, 1.72 [1.49-1.98] and 1.81 [1.45-2.26]), inflammation (white blood cell count, 1.39 [1.23-1.58] and 1.38 [1.13-1.69]), and metabolic dysregulation (triglycerides, 1.25 [1.09-1.44] and 1.31 [1.08-1.58]; glucose, 1.46 [1.23-1.73] and 1.27 [1.05-1.54]) but, more surprisingly, also revealed positive associations with red blood cell count (1.27 [1.11-1.44] and 1.38 [1.14-1.68]), hemoglobin (1.18 [1.03-1.35] and 1.31 [1.05-1.64]), and platelet count (1.39 [1.20-1.61] and 1.33 [1.09-1.63]).
+
+ CONCLUSIONS: In addition to obesity and metabolic dysregulation, increased hemoglobin and counts of platelets, and red and white blood cells are associated with hypertension in this period. Future study may verify whether these associations are causal in nature and whether these variables are useful in risk stratification. Copyright © 2022 by The North American Menopause Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1097%2fGME.0000000000002100
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=He&issn=1072-3714&title=Menopause&atitle=Blood+biomarkers+for+new-onset+hypertension+in+midlife+women%3A+a+nested+case-control+study.&volume=30&issue=2&spage=156&epage=164&date=2023&doi=10.1097%2FGME.0000000000002100&pmid=36696640&sid=OVID:medline
+
+<308>
+Unique Identifier
+ 36654490
+Title
+ Identification of major hub genes involved in high-fat diet-induced obese visceral adipose tissue based on bioinformatics approach.
+Source
+ Adipocyte. 12(1):2169227, 2023 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jiang Y; Zhang R; Guo JQ; Qian LL; Ji JJ; Wu Y; Ji ZJ; Yang ZW; Zhang Y; Chen X; Ma GS; Yao YY
+Author NameID
+ Yao, Yu-Yu; ORCID: https://orcid.org/0000-0001-7841-288X
+Authors Full Name
+ Jiang, Yu; Zhang, Rui; Guo, Jia-Qi; Qian, Ling-Lin; Ji, Jing-Jing; Wu, Ya; Ji, Zhen-Jun; Yang, Zi-Wei; Zhang, Yao; Chen, Xi; Ma, Gen-Shan; Yao, Yu-Yu.
+Institution
+ Jiang, Yu. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+ Zhang, Rui. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+ Guo, Jia-Qi. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+ Qian, Ling-Lin. Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, P. R. China.
+ Ji, Jing-Jing. Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China.
+ Wu, Ya. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+ Ji, Zhen-Jun. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+ Yang, Zi-Wei. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+ Zhang, Yao. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+ Chen, Xi. Department of Cardiology, Anqing First People's Hospital of Anhui Province, Anqing, P. R. China.
+ Ma, Gen-Shan. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+ Yao, Yu-Yu. Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.
+MeSH Subject Headings
+ Animals
+ Mice
+ Biomarkers/me [Metabolism]
+ Computational Biology
+ *Diet, High-Fat
+ Intra-Abdominal Fat/me [Metabolism]
+ *Intra-Abdominal Fat
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+Keyword Heading
+ Obesity
+ bioinformatics analysis
+ biomarker
+ fibrosis
+ high-fat diet
+ inflammation
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ High-fat diet (HFD) can cause obesity, inducing dysregulation of the visceral adipose tissue (VAT). This study aimed to explore potential biological pathways and hub genes involved in obese VAT, and for that, bioinformatic analysis of multiple datasets was performed. The expression profiles (GSE30247, GSE167311 and GSE79434) were downloaded from Gene Expression Omnibus. Overlapping differentially expressed genes (ODEGs) between normal diet and HFD groups in GSE30247 and GSE167311 were selected to run protein-protein interaction network, GO and KEGG analysis. The hub genes in ODEGs were screened by Cytoscape software and further verified in GSE79434 and obese mouse model. A total of 747 ODEGs (599 up-regulated and 148 down-regulated) were screened, and the GO and KEGG analysis showed that the up-regulated ODEGs were significantly enriched in inflammatory response and extracellular matrix receptor interaction pathways. On the other hand, the down-regulated ODEGs were involved in metabolic pathways; however, there were no significant KEGG pathways. Furthermore, six hub genes, Mki67, Rac2, Itgb2, Emr1, Tyrobp and Csf1r were acquired. These pathways and genes were verified in GSE79434 and VAT of obese mice. This study revealed that HFD induced VAT expansion, inflammation and fibrosis, and the hub genes could be used as therapeutic biomarkers in obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1080%2f21623945.2023.2169227
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jiang&issn=2162-3945&title=Adipocyte&atitle=Identification+of+major+hub+genes+involved+in+high-fat+diet-induced+obese+visceral+adipose+tissue+based+on+bioinformatics+approach.&volume=12&issue=1&spage=2169227&epage=&date=2023&doi=10.1080%2F21623945.2023.2169227&pmid=36654490&sid=OVID:medline
+
+<309>
+Unique Identifier
+ 36654481
+Title
+ The effect of concentrated pomegranate juice on biomarkers of inflammation, oxidative stress, and sex hormones in overweight and obese women with polycystic ovary syndrome: A randomized controlled trial.
+Source
+ Phytotherapy Research. 37(6):2255-2261, 2023 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abedini M; Ramezani-Jolfaie N; Ghasemi-Tehrani H; Tarrahi MJ; Amani R
+Author NameID
+ Abedini, Maryam; ORCID: https://orcid.org/0000-0002-7123-7481
+ Ramezani-Jolfaie, Nahid; ORCID: https://orcid.org/0000-0002-2233-8665
+Authors Full Name
+ Abedini, Maryam; Ramezani-Jolfaie, Nahid; Ghasemi-Tehrani, Hatav; Tarrahi, Mohammad Javad; Amani, Reza.
+Institution
+ Abedini, Maryam. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Ramezani-Jolfaie, Nahid. Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
+ Ramezani-Jolfaie, Nahid. Department of Community Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
+ Ghasemi-Tehrani, Hatav. Department of Reproductive, Shahid Beheshti Fertility and Infertility Clinic, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Tarrahi, Mohammad Javad. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Amani, Reza. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
+MeSH Subject Headings
+ Female
+ Humans
+ Adolescent
+ Young Adult
+ Adult
+ Overweight
+ *Polycystic Ovary Syndrome
+ *Pomegranate
+ Gonadal Steroid Hormones/pd [Pharmacology]
+ Obesity/co [Complications]
+ Biomarkers
+ Oxidative Stress
+ Inflammation
+ Testosterone
+Keyword Heading
+ gonadal hormones
+ inflammation
+ oxidative stress
+ polycystic ovary syndrome
+ pomegranate
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder. Pomegranate juice (PJ) has been known to play anti-inflammatory and antioxidant roles. However, the effects of PJ on inflammation, oxidative stress, and sex hormones in PCOS patients are very little studied, and thus more studies are needed. This randomized controlled trial enrolled 44 women diagnosed with PCOS according to the Rotterdam criteria, body mass index (BMI) >= 25 kg/m2 , and aged 18-40 years old. Participants were randomly assigned to take 45 ml/day of concentrated PJ or a control group without intervention. Some biomarkers of sex hormones, inflammation, and oxidative stress were quantified at baseline and after the 8-week intervention. Compared with the controls, serum testosterone levels were significantly decreased in overweight and obese women with PCOS who supplemented with concentrated PJ (-0.004 +/- 0.013 vs. 0.039 +/- 0.013, p = .039). However, we did not observe significant differences in luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) levels and inflammation and oxidative stress factors between the two groups after adjustment for confounding variables. An 8-week supplementation with concentrated PJ could effectively improve testosterone levels in overweight and obese women with PCOS. This study was registered at www.irct.ir (IRCT20191109045383N1). Copyright © 2023 John Wiley & Sons, Ltd.
+Registry Number/Name of Substance
+ 0 (Gonadal Steroid Hormones). 0 (Biomarkers). 3XMK78S47O (Testosterone).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2fptr.7731
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abedini&issn=0951-418X&title=Phytotherapy+Research&atitle=The+effect+of+concentrated+pomegranate+juice+on+biomarkers+of+inflammation%2C+oxidative+stress%2C+and+sex+hormones+in+overweight+and+obese+women+with+polycystic+ovary+syndrome%3A+A+randomized+controlled+trial.&volume=37&issue=6&spage=2255&epage=2261&date=2023&doi=10.1002%2Fptr.7731&pmid=36654481&sid=OVID:medline
+
+<310>
+Unique Identifier
+ 36650653
+Title
+ Non-Insulin-Based Insulin Resistance Indices and Localized Periodontitis in Physically Active Young Male Adults: CHIEF Oral Health Study.
+Source
+ Endocrine, Metabolic & Immune Disorders Drug Targets. 23(7):937-946, 2023.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tsai KZ; Lin YP; Lai SW; Liu CH; Chang YC; Lin GM
+Authors Full Name
+ Tsai, Kun-Zhe; Lin, Yen-Po; Lai, Shiue-Wei; Liu, Chia-Hsin; Chang, Yun-Chen; Lin, Gen-Min.
+Institution
+ Tsai, Kun-Zhe. Department of Medicine, Hualien Armed Forces General Hospital, Hualien City, Taiwan.
+ Tsai, Kun-Zhe. Department of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei, Taiwan.
+ Tsai, Kun-Zhe. Department of Dentistry, Tri-Service General Hospital, National Defence Medical Center, Taipei, Taiwan.
+ Lin, Yen-Po. Department of Critical Medicine Medicine, Taipei Tzu Chi General Hospital, New Taipei City, Taiwan.
+ Lai, Shiue-Wei. Department of Medicine, Tri-Service General Hospital, National Defence Medical Center, Taipei, Taiwan.
+ Liu, Chia-Hsin. Department of Medicine, Tri-Service General Hospital, National Defence Medical Center, Taipei, Taiwan.
+ Chang, Yun-Chen. School of Nursing and Graduate Institute of Nursing, China Medical University, Taichung 406, Taiwan.
+ Lin, Gen-Min. Department of Medicine, Tri-Service General Hospital, National Defence Medical Center, Taipei, Taiwan.
+MeSH Subject Headings
+ Young Adult
+ Humans
+ Male
+ Middle Aged
+ *Insulin Resistance
+ Blood Glucose/an [Analysis]
+ Oral Health
+ Glucose
+ Obesity
+ Triglycerides
+ Cholesterol, HDL
+ Biomarkers
+Keyword Heading
+ Insulin resistance
+ TG/HDL-C ratio
+ TyG index
+ multiple logistic regression
+ periodontitis
+ serum triglycerides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: This study aims to examine the association between non-insulin-based insulin resistance indices and periodontitis severity in young males.
+
+ BACKGROUND: Periodontitis has been reported with an association with insulin resistance in middle- and old-aged adults.
+
+ OBJECTIVE: The association between insulin resistance and localized periodontitis in young adults is unclear.
+
+ METHODS: A total of non-diabetic 1,111 military males in Taiwan were included in this study. Localized periodontitis was classified as healthy (N =665), stage I (N =130), stage II (N =161), and stage III (N =155) based on the world workshop in 2017. Insulin resistance was assessed by serum triglycerides concentrations, the triglycerides glucose (TyG) index, the product of serum triglycerides and fasting glucose, and the ratio of serum triglycerides to high-density lipoprotein cholesterol (TG/HDL-C). Multiple logistic regression analysis with adjustment for age, tobacco smoking, alcohol intake, abdominal obesity, and hypertension was used to determine the associations.
+
+ RESULTS: Serum TG concentrations, TyG index, and TG/HDL-C ratio were dose-dependently associated with a greater risk of localized periodontitis severity (from stage I to stage III) [odds ratios and 95% confidence intervals: 1.001 (0.999-1.004), 1.003 (1.001-1.004) and 1.003 (1.002- 1.005) for TG; 1.45 (1.03-2.03), 1.65 (1.22-2.22) and 1.66 (1.22-2.26) for TyG index; 1.06 (0.99- 1.14), 1.09 (1.03-1.15) and 1.10 (1.04-1.16) for TG/HDL-C ratio]. However, the association was only found in obese individuals and those free of impaired fasting glucose.
+
+ CONCLUSION: The present study confirmed that periodontitis may lead to insulin resistance in young male adults, particularly for those with obesity and without hyperglycemia. The TyG index is suggestive as the strongest indicator for the association between insulin resistance and periodontitis in young adults. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Blood Glucose). IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Cholesterol, HDL). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.2174%2f1871530323666230117112936
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tsai&issn=1871-5303&title=Endocrine%2C+Metabolic+%26+Immune+Disorders+Drug+Targets&atitle=Non-Insulin-Based+Insulin+Resistance+Indices+and+Localized+Periodontitis+in+Physically+Active+Young+Male+Adults%3A+CHIEF+Oral+Health+Study.&volume=23&issue=7&spage=937&epage=946&date=2023&doi=10.2174%2F1871530323666230117112936&pmid=36650653&sid=OVID:medline
+
+<311>
+Unique Identifier
+ 36649519
+Title
+ The Relationship between Zonulin and Metabolic Syndrome in Renal Transplant Patients.
+Source
+ Clinical Laboratory. 69(1), 2023 Jan 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Erkan GC; Sumnu A; Ertugrul G; Ulfer G; Cakici C; Aydin HC; Unal A
+Authors Full Name
+ Erkan, Gulbanu Canbaloglu; Sumnu, Abdullah; Ertugrul, Gokhan; Ulfer, Gozde; Cakici, Cagri; Aydin, Huseyin Cagatay; Unal, Aydin.
+MeSH Subject Headings
+ Adult
+ Humans
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome
+ Kidney Transplantation/ae [Adverse Effects]
+ *Kidney Transplantation
+ Obesity
+ Haptoglobins
+ Glucose
+ Biomarkers
+ Permeability
+Abstract
+ BACKGROUND: Levels of zonulin, a surrogate marker of intestinal permeability, are elevated in various disorders including insulin resistance, obesity, celiac disease, and inflammatory bowel disease. We aimed to elucidate the association of zonulin levels and metabolic syndrome (MS) in renal transplant recipients.
+
+ METHODS: Seventy-nine renal transplant recipients were enrolled. Diagnosis of MS was established employing the Adult Treatment Panel III (ATP III) criteria. Serum zonulin level was determined using the double antibody sandwich ELISA method.
+
+ RESULTS: MS was encountered in 37 (41.6%) of the 79 patients. Serum zonulin level was significantly higher in patients with MS compared to those without MS (p < 0.001). Serum zonulin level correlated with presence of MS (r: 739, p < 0.001), abdominal obesity (r: 514, p < 0.001), fasting glucose level (r: 361, p: 0.001), presence of fasting glucose/diabetes criterion of MS (r: 316, p: 0.005), presence of low HDL criterion of MS (r: 266, p: 0.018), and BMI (r: 527, p < 0.001).
+
+ CONCLUSIONS: A Zonulin-mediated increase in intestinal permeability may play a role in the pathogenesis of metabolic syndrome. We propose that zonulin may be a suitable surrogate marker of MS in renal transplant recipients.
+Registry Number/Name of Substance
+ 0 (zonulin). 0 (Haptoglobins). IY9XDZ35W2 (Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.7754%2fClin.Lab.2022.220341
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Erkan&issn=1433-6510&title=Clinical+Laboratory&atitle=The+Relationship+between+Zonulin+and+Metabolic+Syndrome+in+Renal+Transplant+Patients.&volume=69&issue=1&spage=&epage=&date=2023&doi=10.7754%2FClin.Lab.2022.220341&pmid=36649519&sid=OVID:medline
+
+<312>
+Unique Identifier
+ 36648947
+Title
+ Association of Body Weight With Response to Vitamin D Supplementation and Metabolism.
+Source
+ JAMA Network Open. 6(1):e2250681, 2023 01 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tobias DK; Luttmann-Gibson H; Mora S; Danik J; Bubes V; Copeland T; LeBoff MS; Cook NR; Lee IM; Buring JE; Manson JE
+Authors Full Name
+ Tobias, Deirdre K; Luttmann-Gibson, Heike; Mora, Samia; Danik, Jacqueline; Bubes, Vadim; Copeland, Trisha; LeBoff, Meryl S; Cook, Nancy R; Lee, I-Min; Buring, Julie E; Manson, JoAnn E.
+Institution
+ Tobias, Deirdre K. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Tobias, Deirdre K. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
+ Luttmann-Gibson, Heike. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Luttmann-Gibson, Heike. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
+ Mora, Samia. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Mora, Samia. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Danik, Jacqueline. Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston.
+ Bubes, Vadim. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Copeland, Trisha. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ LeBoff, Meryl S. Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Cook, Nancy R. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Cook, Nancy R. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
+ Lee, I-Min. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Lee, I-Min. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
+ Buring, Julie E. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Buring, Julie E. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
+ Manson, JoAnn E. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Manson, JoAnn E. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Aged
+ Female
+ Humans
+ Biomarkers
+ *Calcium
+ Cohort Studies
+ Dietary Supplements
+ Obesity
+ *Overweight
+ Parathyroid Hormone
+ Vitamin D
+ Vitamins/tu [Therapeutic Use]
+ Male
+ Middle Aged
+Abstract
+ Importance: In the Vitamin D and Omega-3 Trial (VITAL), the effects of randomized vitamin D supplementation (cholecalciferol), 2000 IU/d, reduced the risk of several health outcomes among participants with normal, but not elevated, body weights. It was unclear whether weight had any association with the outcomes of the supplementation.
+
+ Objective: To investigate whether baseline body mass index (BMI) modifies vitamin D metabolism and response to supplementation.
+
+ Design, Setting, and Participants: VITAL is a completed randomized, double-blind, placebo-controlled trial for the primary prevention of cancer and cardiovascular disease. In the present cohort study, an analysis was conducted in a subset of VITAL participants who provided a blood sample at baseline and a subset with a repeated sample at 2 years' follow-up. VITAL was conducted from July 1, 2010, to November 10, 2018; data analysis for the present study was conducted from August 1, 2021, to November 9, 2021.
+
+ Interventions: Treatment outcomes of vitamin D, 2000 IU/d, supplementation vs placebo associated with clinical and novel vitamin D-related biomarkers by BMI category adjusted for other factors associated with vitamin D status.
+
+ Main Outcomes and Measures: Multivariable-adjusted means (SE) or 95% CIs of vitamin D-related serum biomarkers at baseline and follow-up: total 25-hydroxyvitamin D (25-OHD), 25-OHD3, free vitamin D (FVD), bioavailable vitamin D (BioD), vitamin D-binding protein (VDBP), albumin, parathyroid hormone (PTH), and calcium, and log-transformed as needed.
+
+ Results: A total of 16515 participants (mean [SD] age, 67.7 [7.0] years; 8371 women [50.7%]; 12420 non-Hispanic White [76.9%]) were analyzed at baseline, including 2742 with a follow-up blood sample. Before randomization, serum total 25-OHD levels were incrementally lower at higher BMI categories (adjusted mean [SE]: underweight, 32.3 [0.7] ng/mL; normal weight, 32.3 [0.1] ng/mL; overweight, 30.5 [0.1] ng/mL; obesity class I, 29.0 [0.2] ng/mL; and obesity class II, 28.0 [0.2] ng/mL; P < .001 for linear trend). Similarly, baseline 25-OHD3, FVD, BioD, VDBP, albumin, and calcium levels were lower with higher BMI, while PTH level was higher (all P < .001 for linear trend). Compared with placebo, randomization to vitamin D supplementation was associated with an increase in total 25-OHD, 25-OHD3, FVD, and BioD levels compared with placebo at 2 years' follow-up, but increases were significantly lower at higher BMI categories (all treatment effect interactions P < .001). Supplementation did not substantially change VDBP, albumin, PTH, or calcium levels.
+
+ Conclusions and Relevance: In this randomized cohort study, vitamin D supplementation increased serum vitamin D-related biomarkers, with a blunted response observed for participants with overweight or obesity at baseline. These longitudinal findings suggest that BMI may be associated with modified response to vitamin D supplementation and may in part explain the observed diminished outcomes of supplementation for various health outcomes among individuals with higher BMI.
+Registry Number/Name of Substance
+ 0 (Biomarkers). SY7Q814VUP (Calcium). 0 (Parathyroid Hormone). 1406-16-2 (Vitamin D). 0 (Vitamins).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1001%2fjamanetworkopen.2022.50681
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tobias&issn=2574-3805&title=JAMA+Network+Open&atitle=Association+of+Body+Weight+With+Response+to+Vitamin+D+Supplementation+and+Metabolism.&volume=6&issue=1&spage=e2250681&epage=&date=2023&doi=10.1001%2Fjamanetworkopen.2022.50681&pmid=36648947&sid=OVID:medline
+
+<313>
+Unique Identifier
+ 36642614
+Title
+ Inflammation biomarkers and inflammatory genes expression in metabolically healthy obese patients.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 33(3):584-591, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Spoto B; Di Betta E; Pizzini P; Lonardi S; Mallamaci F; Tripepi G; Kanbay M; Cancarini G; Zoccali C
+Authors Full Name
+ Spoto, Belinda; Di Betta, Ernesto; Pizzini, Patrizia; Lonardi, S; Mallamaci, F; Tripepi, G; Kanbay, Mehmet; Cancarini, Giovanni; Zoccali, Carmine.
+Institution
+ Spoto, Belinda. CNR-IFC, Institute of Clinical Physiology, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
+ Di Betta, Ernesto. Division of Vascular Surgery, Department of Clinical and Experimental Sciences, University of Brescia and Spedali Civili Hospital, Brescia, Italy.
+ Pizzini, Patrizia. CNR-IFC, Institute of Clinical Physiology, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
+ Lonardi, S. Section of Pathology, University of Brescia, Italy.
+ Mallamaci, F. CNR-IFC, Institute of Clinical Physiology, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy; Unita Operativa di Nefrologia e Trapianto renale, Grande Ospedale Metropolitano, Reggio Calabria, Italy.
+ Tripepi, G. CNR-IFC, Institute of Clinical Physiology, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
+ Kanbay, Mehmet. Division of Nephrology, Department of Internal Medicine, Koc University School of Medicine, Istanbul 34010, Turkey.
+ Cancarini, Giovanni. Ethics Committee, University of Brescia and Spedali Civili Hospital, Brescia, Italy.
+ Zoccali, Carmine. Renal Research Institute, New York, USA and Institute of Molecular Biology and Genetics (BIOGEM), Ariano Iripino, Italy and Associazione Ipertensione Nefrologia e Trapianto Renale (IPNET), Reggio Calabria, Italy. Electronic address: carmine.zoccali@icloud.com.
+MeSH Subject Headings
+ Humans
+ Obesity/di [Diagnosis]
+ Obesity/ge [Genetics]
+ Inflammation/di [Diagnosis]
+ Inflammation/ge [Genetics]
+ Biomarkers/me [Metabolism]
+ Obesity, Metabolically Benign/di [Diagnosis]
+ Obesity, Metabolically Benign/ge [Genetics]
+ Obesity, Metabolically Benign/co [Complications]
+ *Obesity, Metabolically Benign
+ Cytokines/ge [Genetics]
+ Adipokines/ge [Genetics]
+ *Metabolic Syndrome
+Keyword Heading
+ Cytokines
+ Gene expression
+ Metabolically healthy obesity
+ Obesity
+ Subcutaneous adipose tissue
+ Visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Obesity without metabolic alterations (Metabolically Healthy Obesity, MHO) is a condition with a risk of death and cardiovascular disease lower than that of obesity associated with metabolic alterations (Metabolically Unhealthy Obesity, MUO) and similar to that of healthy non obese individuals. Inflammation is considered as a key risk factor mediating the adverse health outcomes in obesity.
+
+ METHODS AND RESULTS: We compared circulating levels of thirteen major cytokines and adipokines and the expression profiles of fifteen pro-inflammatory and two anti-inflammatory genes in visceral and subcutaneous adipose tissue in a series of 16 MHO patients and in 32 MUO patients that underwent bariatric surgery. MHO was defined according to the most applied definition in current literature. Serum levels of a large set of major cytokines and adipokines did not differ between MHO and MUO patients (p >= 0.15). Analyses of the expression profile of pro-inflammatory and anti-inflammatory genes in subcutaneous and visceral adipose tissue failed to show differences between MHO and MUO patients (p >= 0.07). Sensitivity analyses applying two additional definitions of MHO confirmed the results of the primary analysis.
+
+ CONCLUSION: In a series of metabolically healthy obese patients neither circulating levels of major cytokines and adipokines nor the gene expression profile of a large set of pro-inflammatory and anti-inflammatory genes in subcutaneous and visceral fat differed from those in metabolically unhealthy obese patients. Copyright © 2022. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Adipokines).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.numecd.2022.12.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Spoto&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Inflammation+biomarkers+and+inflammatory+genes+expression+in+metabolically+healthy+obese+patients.&volume=33&issue=3&spage=584&epage=591&date=2023&doi=10.1016%2Fj.numecd.2022.12.008&pmid=36642614&sid=OVID:medline
+
+<314>
+Unique Identifier
+ 36642606
+Title
+ Association of triglyceride-glucose index and its 6-year change with risk of hypertension: A prospective cohort study.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 33(3):568-576, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhao Y; Yang X; Wu Y; Huang H; Hu F; Zhang M; Sun L; Hu D
+Authors Full Name
+ Zhao, Yang; Yang, Xingjin; Wu, Yuying; Huang, Hao; Hu, Fulan; Zhang, Ming; Sun, Liang; Hu, Dongsheng.
+Institution
+ Zhao, Yang. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
+ Yang, Xingjin. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
+ Wu, Yuying. Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
+ Huang, Hao. Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
+ Hu, Fulan. Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
+ Zhang, Ming. Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
+ Sun, Liang. Department of Social Medicine and Health Service Management, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address: doubleliang@126.com.
+ Hu, Dongsheng. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address: dongshenghu563@126.com.
+MeSH Subject Headings
+ Humans
+ *Glucose
+ Triglycerides
+ Risk Factors
+ Blood Glucose
+ Prospective Studies
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ *Hypertension
+ Biomarkers
+Keyword Heading
+ Epidemiology
+ Hypertension
+ Insulin resistance
+ Triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: We aimed to investigate the association of triglyceride-glucose (TyG) index and its dynamic change with risk of hypertension in rural Chinese and, further, to explore whether the TyG index mediates the obesity-related hypertension.
+
+ METHODS AND RESULTS: A prospective cohort study, including 10,309 subjects without hypertension at baseline, was conducted in 2007-2008 and followed up in 2013-2014. TyG index was calculated as Ln[fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. Logistic regression model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Mediation analysis was performed to examine the contribution of the TyG index to the association of obesity-hypertension incidence. During a median follow-up of 6 years, 2073 subjects developed hypertension. In multivariate logistic model adjusted for age, sex, alcohol drinking, smoking, physical activity and education, monthly income, family history of hypertension, TC, and HDL-C, the risk of hypertension was 1.14 (1.07-1.22) for per-SD increase in TyG. After additional controlling for obesity, this association was nonsignificant (1.06, 0.99-1.13) and (1.05, 0.99-1.13) for BMI and WC, respectively. Increasing trends were found for hypertension incidence as the TyG change increased, with or without adjustment for obesity (all Ptrend < 0.05). With per-SD increment in TyG change, the risks of hypertension incidence were 1.14 (1.07-1.22) for absolute TyG change, and 1.15 (1.08-1.22) for relative TyG change in multivariate logistic model; the results were significant after further adjustment for BMI or WC, respectively. The TyG index partially mediated the obesity-incident hypertension association: 6.84% for BMI and 6.68% for WC, respectively.
+
+ CONCLUSIONS: Elevated TyG index and its dynamic change were positively associated with risk of incident hypertension in rural Chinese population, and the TyG index may play a partially mediating role in obesity-related incident hypertension. Copyright © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Blood Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.numecd.2022.12.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhao&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Association+of+triglyceride-glucose+index+and+its+6-year+change+with+risk+of+hypertension%3A+A+prospective+cohort+study.&volume=33&issue=3&spage=568&epage=576&date=2023&doi=10.1016%2Fj.numecd.2022.12.001&pmid=36642606&sid=OVID:medline
+
+<315>
+Unique Identifier
+ 36639961
+Title
+ Short-term evaluation of renal markers in overweight adult cats.
+Source
+ Veterinary Medicine & Science. 9(2):572-578, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Perez-Lopez L; Boronat M; Melian C; Santana A; Brito-Casillas Y; Wagner AM
+Author NameID
+ Perez-Lopez, Laura; ORCID: https://orcid.org/0000-0003-0541-3675
+Authors Full Name
+ Perez-Lopez, Laura; Boronat, Mauro; Melian, Carlos; Santana, Angelo; Brito-Casillas, Yeray; Wagner, Ana M.
+Institution
+ Perez-Lopez, Laura. Instituto Universitario de Investigaciones Biomedicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain.
+ Boronat, Mauro. Instituto Universitario de Investigaciones Biomedicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain.
+ Boronat, Mauro. Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Canary Islands, Spain.
+ Melian, Carlos. Instituto Universitario de Investigaciones Biomedicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain.
+ Melian, Carlos. Veterinary Faculty, Department of Animal Pathology, University of Las Palmas de Gran Canaria, Arucas, Canary Islands, Spain.
+ Santana, Angelo. Department of Mathematics and Statistics, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain.
+ Brito-Casillas, Yeray. Instituto Universitario de Investigaciones Biomedicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain.
+ Wagner, Ana M. Instituto Universitario de Investigaciones Biomedicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain.
+ Wagner, Ana M. Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Canary Islands, Spain.
+MeSH Subject Headings
+ Cats
+ Animals
+ Male
+ Overweight/ve [Veterinary]
+ Creatinine
+ Biomarkers
+ Kidney/ph [Physiology]
+ Renal Insufficiency, Chronic/ve [Veterinary]
+ *Renal Insufficiency, Chronic
+ Obesity/ve [Veterinary]
+ *Cat Diseases
+Keyword Heading
+ chronic kidney disease
+ creatinine
+ obesity
+ symmetric dimethylarginine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity has been proposed as an independently risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown.
+
+ OBJECTIVE: Obesity has been proposed as an independent risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. This study prospectively evaluated the effect of overweight on the concentration of symmetric dimethylarginine (SDMA) and creatinine in a cohort of healthy cats.
+
+ METHODS: Forty healthy adult cats were included, 14 with a body condition score (BCS) = 5 and 26 with a BCS > 5. Cats were examined every 6 months, for up to 12 months. SDMA and creatinine were measured at baseline and follow-up.
+
+ RESULTS: No effect was found for time of follow-up (p = 0.072), overweight (p = 0.9442) or their interaction (p = 0.902) on SDMA, though a significant effect was found for age (p < 0.001) [older cats showing higher SDMA] and sex (p = 0.007) [male cats showing higher SDMA]. Regarding creatinine, no effect for time (p = 0.671), age (p = 0.061), overweight (p = 0.319) or the latter's interaction (p = 0.386) were found.
+
+ CONCLUSIONS: In the short term, markers of renal function did not show an association with overweight. The role of obesity in feline kidney function still warrants further evaluation. Copyright © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ AYI8EX34EU (Creatinine). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2fvms3.1021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Perez-Lopez&issn=2053-1095&title=Veterinary+Medicine+%26+Science&atitle=Short-term+evaluation+of+renal+markers+in+overweight+adult+cats.&volume=9&issue=2&spage=572&epage=578&date=2023&doi=10.1002%2Fvms3.1021&pmid=36639961&sid=OVID:medline
+
+<316>
+Unique Identifier
+ 36615908
+Title
+ Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice.
+Source
+ Nutrients. 15(1), 2023 Jan 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yan J; Ren C; Dong Y; Wali JA; Song H; Zhang Y; Zhang H; Kou G; Raubenheimer D; Cui Z
+Author NameID
+ Wali, Jibran A; ORCID: https://orcid.org/0000-0002-8524-5773
+Authors Full Name
+ Yan, Jiabao; Ren, Cuiru; Dong, Yunlong; Wali, Jibran A; Song, Hongjie; Zhang, Ying; Zhang, Hengrui; Kou, Guangning; Raubenheimer, David; Cui, Zhenwei.
+Institution
+ Yan, Jiabao. Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (main campus), Zhengzhou University, Zhengzhou 450001, China.
+ Ren, Cuiru. Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (main campus), Zhengzhou University, Zhengzhou 450001, China.
+ Dong, Yunlong. Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (main campus), Zhengzhou University, Zhengzhou 450001, China.
+ Wali, Jibran A. Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
+ Song, Hongjie. Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (main campus), Zhengzhou University, Zhengzhou 450001, China.
+ Zhang, Ying. Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (main campus), Zhengzhou University, Zhengzhou 450001, China.
+ Zhang, Hengrui. School of Physical Education, Zhengzhou University of Light Industry, Zhengzhou 450002, China.
+ Kou, Guangning. Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (main campus), Zhengzhou University, Zhengzhou 450001, China.
+ Raubenheimer, David. Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (main campus), Zhengzhou University, Zhengzhou 450001, China.
+ Raubenheimer, David. Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
+ Cui, Zhenwei. Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (main campus), Zhengzhou University, Zhengzhou 450001, China.
+MeSH Subject Headings
+ Humans
+ Mice
+ Animals
+ *Diet, Ketogenic
+ Diet, High-Fat/ae [Adverse Effects]
+ Lipid Metabolism
+ Mice, Obese
+ Obesity/et [Etiology]
+ Obesity/th [Therapy]
+ Body Weight
+ *Fatty Liver
+ Adipose Tissue, White
+ Triglycerides
+ Biomarkers
+ Adipose Tissue
+ Mice, Inbred C57BL
+Keyword Heading
+ aerobic exercise
+ ketogenic diet
+ lipid metabolism
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a serious public health issue worldwide. Growing evidence demonstrates the efficacy of the ketogenic diet (KD) for weight loss, but there may be some adverse side effects such as dyslipidemia and hepatic steatosis. Aerobic exercise is a widely recognized approach for improving these metabolic markers. Here we explored the combined impacts of KD and moderate aerobic exercise for an 8-week intervention on body weight and fat loss, serum biomarkers, and hepatic lipid metabolism in a mouse model of high-fat diet-induced obesity. Both KD and KD combined with exercise significantly reduced body weight and fat mass. No significant adverse effects of KD were observed in serum biomarkers or hepatic lipid storage, except for an increase in circulating triglyceride level. However, aerobic exercise lowered serum triglyceride levels, and further ameliorated serum parameters, and hepatic steatosis in KD-fed mice. Moreover, gene and protein expression analysis indicated that KD combined with exercise was associated with increased expression of lipolysis-related genes and protein levels, and reduced expression of lipogenic genes relative to KD without exercise. Overall, our findings for mice indicate that further work on humans might reveal that KD combined with moderate aerobic exercise could be a promising therapeutic strategy for obesity.
+Registry Number/Name of Substance
+ 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.3390%2fnu15010251
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yan&issn=2072-6643&title=Nutrients&atitle=Ketogenic+Diet+Combined+with+Moderate+Aerobic+Exercise+Training+Ameliorates+White+Adipose+Tissue+Mass%2C+Serum+Biomarkers%2C+and+Hepatic+Lipid+Metabolism+in+High-Fat+Diet-Induced+Obese+Mice.&volume=15&issue=1&spage=&epage=&date=2023&doi=10.3390%2Fnu15010251&pmid=36615908&sid=OVID:medline
+
+<317>
+Unique Identifier
+ 36609276
+Title
+ Fatty acid-binding protein-4 (FABP4) and matrix metalloproteinase-9 (MMP9) as predictive values for nonalcoholic steatohepatitis (NASH).
+Source
+ Lipids in Health & Disease. 22(1):1, 2023 Jan 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wagner J; Kumar Y; Lautenbach A; von Kroge P; Wolter S; Mann O; Izbicki J; Gagliani N; Dupree A
+Authors Full Name
+ Wagner, Jonas; Kumar, Yogesh; Lautenbach, Anne; von Kroge, Philipp; Wolter, Stefan; Mann, Oliver; Izbicki, Jakob; Gagliani, Nicola; Dupree, Anna.
+Institution
+ Wagner, Jonas. Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. jowagner@uke.de.
+ Kumar, Yogesh. Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
+ Lautenbach, Anne. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
+ von Kroge, Philipp. Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
+ Wolter, Stefan. Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
+ Mann, Oliver. Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
+ Izbicki, Jakob. Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
+ Gagliani, Nicola. Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
+ Gagliani, Nicola. Department of Medicine, Section of Molecular Immunology und Gastroenterology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
+ Dupree, Anna. Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
+MeSH Subject Headings
+ Humans
+ *Non-alcoholic Fatty Liver Disease
+ Matrix Metalloproteinase 9
+ Liver Cirrhosis/pa [Pathology]
+ Obesity/pa [Pathology]
+ Fatty Acid-Binding Proteins
+ Biopsy
+ Liver/pa [Pathology]
+ Biomarkers
+Keyword Heading
+ Bariatric surgery
+ Biomarker
+ FABP4
+ Liver pathology
+ MMP9
+ NAFLD
+ NASH
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis (NASH) increases the risk for liver cirrhosis. Noninvasive tests for NAFLD/NASH exist, but they are unreliable and thus liver biopsy remains the standard for diagnosis and new noninvasive diagnostic approaches are of great interest. The aim of this study was to test whether the serum levels of fatty acid-binding protein-4 (FABP4) and matrix metalloproteinase-9 (MMP9) could be used as a diagnostic tool for NASH.
+
+ METHODS: Patients who underwent bariatric surgery and simultaneous liver biopsy were identified. Biopsies were assigned a NAFLD activity score (NAS). MMP9- and FABP4- Enzyme-linked Immunosorbent Assays (ELISAs) on serum samples were performed. The serum levels of FABP4/MMP9 were compared and different models to predict NASH were developed.
+
+ RESULTS: A total of 84 patients were included, 28 patients (33.3%) were diagnosed with NASH. Higher concentrations of MMP9 in NASH patients (p < 0.01) were detected. FABP4 concentrations were not significantly increased. A moderate correlation between the NAS and MMP9 concentrations (r = 0.32, P < 0.01) was observed. The neural network model fit best with the dataset, with an area under the curve (AUC) of 83% and an accuracy of 88%.
+
+ CONCLUSION: Serum MMP9 levels are increased in patients with NASH and should routinely be measured in patients with obesity, but further investigations are needed to improve noninvasive NASH diagnosis. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ EC 3-4-24-35 (Matrix Metalloproteinase 9). 0 (Fatty Acid-Binding Proteins). 0 (Biomarkers). 0 (FABP4 protein, human). EC 3-4-24-35 (MMP9 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1186%2fs12944-022-01764-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wagner&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Fatty+acid-binding+protein-4+%28FABP4%29+and+matrix+metalloproteinase-9+%28MMP9%29+as+predictive+values+for+nonalcoholic+steatohepatitis+%28NASH%29.&volume=22&issue=1&spage=1&epage=&date=2023&doi=10.1186%2Fs12944-022-01764-1&pmid=36609276&sid=OVID:medline
+
+<318>
+Unique Identifier
+ 36606041
+Title
+ Weight loss modifies lipid peroxidation and symmetric dimethylarginine levels in obese dogs.
+Source
+ Canadian Journal of Veterinary Research. 87(1):29-34, 2023 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cavalcante CZ; Michelotto PV Jr; Capriglione LGA; Roncoski AT; Nishiyama A
+Authors Full Name
+ Cavalcante, Carolina Zaghi; Michelotto, Pedro Vicente Jr; Capriglione, Luiz Guilherme Achnar; Roncoski, Andressa Thais; Nishiyama, Anita.
+Institution
+ Cavalcante, Carolina Zaghi. Medicina Veterinaria, Escola de Ciencias da Vida, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceicao, 1155, Prado Velho, CEP 80215-901, Curitiba, Parana, Brasil (Cavalcante, Michelotto, Capriglione, Roncoski); Departamento de Fisiologia, Centro Politecnico, Universidade Federal do Parana, Avenida Coronel Francisco H. dos Santos, 100, Jardim das Americas, CEP 80530-000, Curitiba, Parana, Brasil (Nishiyama).
+ Michelotto, Pedro Vicente Jr. Medicina Veterinaria, Escola de Ciencias da Vida, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceicao, 1155, Prado Velho, CEP 80215-901, Curitiba, Parana, Brasil (Cavalcante, Michelotto, Capriglione, Roncoski); Departamento de Fisiologia, Centro Politecnico, Universidade Federal do Parana, Avenida Coronel Francisco H. dos Santos, 100, Jardim das Americas, CEP 80530-000, Curitiba, Parana, Brasil (Nishiyama).
+ Capriglione, Luiz Guilherme Achnar. Medicina Veterinaria, Escola de Ciencias da Vida, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceicao, 1155, Prado Velho, CEP 80215-901, Curitiba, Parana, Brasil (Cavalcante, Michelotto, Capriglione, Roncoski); Departamento de Fisiologia, Centro Politecnico, Universidade Federal do Parana, Avenida Coronel Francisco H. dos Santos, 100, Jardim das Americas, CEP 80530-000, Curitiba, Parana, Brasil (Nishiyama).
+ Roncoski, Andressa Thais. Medicina Veterinaria, Escola de Ciencias da Vida, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceicao, 1155, Prado Velho, CEP 80215-901, Curitiba, Parana, Brasil (Cavalcante, Michelotto, Capriglione, Roncoski); Departamento de Fisiologia, Centro Politecnico, Universidade Federal do Parana, Avenida Coronel Francisco H. dos Santos, 100, Jardim das Americas, CEP 80530-000, Curitiba, Parana, Brasil (Nishiyama).
+ Nishiyama, Anita. Medicina Veterinaria, Escola de Ciencias da Vida, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceicao, 1155, Prado Velho, CEP 80215-901, Curitiba, Parana, Brasil (Cavalcante, Michelotto, Capriglione, Roncoski); Departamento de Fisiologia, Centro Politecnico, Universidade Federal do Parana, Avenida Coronel Francisco H. dos Santos, 100, Jardim das Americas, CEP 80530-000, Curitiba, Parana, Brasil (Nishiyama).
+MeSH Subject Headings
+ Dogs
+ Female
+ Animals
+ Lipid Peroxidation
+ Thiobarbituric Acid Reactive Substances
+ Obesity/ve [Veterinary]
+ *Obesity
+ Weight Loss
+ Biomarkers
+ *Dog Diseases
+Abstract
+ In obese dogs, oxidative stress is associated with inflammatory processes and systemic endocrine imbalances. Monitoring oxidative status is an early and valuable means of obesity control as it is a marker of weight loss, which leads to a reduction in oxidative status or injury potential. The objective of this study was to investgate the changes in the concentrations of thiobarbituric acid reactive substances (TBARS) and symmetric dimethylarginine (SDMA) in obese female dogs subjected to an 8-week weight-loss program. We included obese female dogs without comorbidities and with body condition scores (BCS) of 8 and 9 out of 9. In addition to TBARS and SDMA assessments, laboratory tests of blood and urine (blood count; levels of serum biochemistry; albumin, alanine aminotransferase, alkaline phosphatase, creatinine, urea, triglycerides, cholesterol, and glucose; urinalysis; and albuminuria), systolic blood pressure, and hormone concentrations (insulin, cortisol, and free thyroxine) were carried out before and after the weight-loss program. All the obese dogs presented high TBARS levels. After the program, the dogs showed significant reductions in TBARS (P = 0.005) and SDMA (P = 0.0013). In conclusion, obese female dogs were prone to lipid peroxidation and the TBARS and SDMA levels decreased after the 8-week weight-loss program. Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
+Other Abstract
+ Publisher
+ Chez les chiens obeses, le stress oxydatif est associe a des processus inflammatoires et a des desequilibres endocriniens systemiques. La surveillance de l'etat oxydatif est un moyen precoce et precieux de controle de l'obesite car il s'agit d'un marqueur de perte de poids, ce qui entraine une reduction de l'etat oxydatif ou du potentiel de blessure. L'objectif de cette etude etait d'etudier les modifications des concentrations de substances reactives a l'acide thiobarbiturique (TBARS) et de dimethylarginine symetrique (SDMA) chez des chiennes obeses soumises a un programme d'amaigrissement de huit semaines. Nous avons inclus des chiennes obeses sans comorbidites et avec des scores d'etat corporel (BCS) de 8 et 9 sur 9. En plus des evaluations TBARS et SDMA, des tests de laboratoire sur le sang et l'urine (numeration sanguine; niveaux de biochimie serique; albumine, alanine aminotransferase, phosphatase alcaline, creatinine, uree, triglycerides, cholesterol et glucose; analyse d'urine; et albuminurie), la pression arterielle systolique et les concentrations hormonales (insuline, cortisol et thyroxine libre) ont ete effectuees avant et apres le programme de perte de poids. Tous les chiens obeses presentaient des niveaux eleves de TBARS. Apres le programme, les chiens ont montre des reductions significatives de TBARS (P = 0,005) et de SDMA (P = 0,0013). En conclusion, les chiennes obeses etaient sujettes a la peroxydation lipidique et les niveaux de TBARS et de SDMA ont diminue apres le programme de perte de poids de huit semaines.(Traduit par Docteur Serge Messier).
+ Language: French
+Registry Number/Name of Substance
+ 49787G1ULV (symmetric dimethylarginine). 0 (Thiobarbituric Acid Reactive Substances). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&AN=36606041
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cavalcante&issn=0830-9000&title=Canadian+Journal+of+Veterinary+Research&atitle=Weight+loss+modifies+lipid+peroxidation+and+symmetric+dimethylarginine+levels+in+obese+dogs.&volume=87&issue=1&spage=29&epage=34&date=2023&doi=&pmid=36606041&sid=OVID:medline
+
+<319>
+Unique Identifier
+ 36597718
+Title
+ Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome.
+Source
+ European Journal of Heart Failure. 25(2):163-173, 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van der Hoef CCS; Boorsma EM; Emmens JE; van Essen BJ; Metra M; Ng LL; Anker SD; Dickstein K; Mordi IR; Dihoum A; Lang CC; van Veldhuisen DJ; Lam CSP; Voors AA
+Authors Full Name
+ van der Hoef, Camilla C S; Boorsma, Eva M; Emmens, Johanna E; van Essen, Bart J; Metra, Marco; Ng, Leong L; Anker, Stefan D; Dickstein, Kenneth; Mordi, Ify R; Dihoum, Adel; Lang, Chim C; van Veldhuisen, Dirk J; Lam, Carolyn S P; Voors, Adriaan A.
+Institution
+ van der Hoef, Camilla C S. Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
+ Boorsma, Eva M. Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
+ Emmens, Johanna E. Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
+ van Essen, Bart J. Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
+ Metra, Marco. Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
+ Ng, Leong L. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
+ Ng, Leong L. NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
+ Anker, Stefan D. Department of Cardiology (CVK); and Berlin Institute of Health Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charite Universitatsmedizin, Berlin, Germany.
+ Dickstein, Kenneth. University of Bergen, Bergen, Norway.
+ Dickstein, Kenneth. Stavanger University Hospital, Stavanger, Norway.
+ Mordi, Ify R. Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.
+ Dihoum, Adel. Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.
+ Lang, Chim C. Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.
+ van Veldhuisen, Dirk J. Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
+ Lam, Carolyn S P. Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
+ Lam, Carolyn S P. Saw Swee Hock School of Public Health and National University of Singapore and National University Health System, Singapore.
+ Lam, Carolyn S P. Duke-NUS Medical School Singapore, Singapore.
+ Voors, Adriaan A. Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
+MeSH Subject Headings
+ Humans
+ *Metabolic Syndrome
+ *Heart Failure
+ *Insulin Resistance
+ Obesity
+ Biomarkers
+ Inflammation
+ Chronic Disease
+Keyword Heading
+ Biomarkers
+ Chronic heart failure
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: The comorbidities that collectively define metabolic syndrome are common in patients with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart failure is not well understood. We therefore investigated the clinical and biomarker correlates of metabolic syndrome in patients with heart failure.
+
+ METHODS AND RESULTS: In 1103 patients with heart failure, we compared the biomarker expression using a panel of 363 biomarkers among patients with (n = 468 [42%]) and without (n = 635 [58%]) metabolic syndrome. Subsequently, a pathway overrepresentation analysis was performed to identify key biological pathways. Findings were validated in an independent cohort of 1433 patients with heart failure of whom 615 (43%) had metabolic syndrome. Metabolic syndrome was defined as the presence of three or more of five criteria, including central obesity, elevated serum triglycerides, reduced high-density lipoprotein cholesterol, insulin resistance and hypertension. The most significantly elevated biomarkers in patients with metabolic syndrome were leptin (log2 fold change 0.92, p = 5.85 x 10-21 ), fatty acid-binding protein 4 (log2 fold change 0.61, p = 1.21 x 10-11 ), interleukin-1 receptor antagonist (log2 fold change 0.47, p = 1.95 x 10-13 ), tumour necrosis factor receptor superfamily member 11a (log2 fold change 0.35, p = 4.16 x 10-9 ), and proto-oncogene tyrosine-protein kinase receptor Ret (log2 fold change 0.31, p = 4.87 x 10-9 ). Network analysis identified 10 pathways in the index cohort and 6 in the validation cohort, all related to inflammation. The primary overlapping pathway in both the index and validation cohorts was up-regulation of the natural killer cell-mediated cytotoxicity pathway.
+
+ CONCLUSION: Metabolic syndrome is highly prevalent in heart failure and is associated with biomarkers and pathways relating to obesity, lipid metabolism and immune responses underlying chronic inflammation. Copyright © 2023 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2fejhf.2760
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+der+Hoef&issn=1388-9842&title=European+Journal+of+Heart+Failure&atitle=Biomarker+signature+and+pathophysiological+pathways+in+patients+with+chronic+heart+failure+and+metabolic+syndrome.&volume=25&issue=2&spage=163&epage=173&date=2023&doi=10.1002%2Fejhf.2760&pmid=36597718&sid=OVID:medline
+
+<320>
+Unique Identifier
+ 36564895
+Title
+ Whole-Genome Transcriptomics of PBMC to Identify Biomarkers of Early Metabolic Risk in Apparently Healthy People with Overweight-Obesity and in Normal-Weight Subjects.
+Source
+ Molecular Nutrition & Food Research. 67(4):e2200503, 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Costa A; van der Stelt I; Reynes B; Konieczna J; Fiol M; Keijer J; Palou A; Romaguera D; van Schothorst EM; Oliver P
+Author NameID
+ Costa, Andrea; ORCID: https://orcid.org/0000-0002-8393-4639
+ Keijer, Jaap; ORCID: https://orcid.org/0000-0002-9720-7491
+Authors Full Name
+ Costa, Andrea; van der Stelt, Inge; Reynes, Barbara; Konieczna, Jadwiga; Fiol, Miquel; Keijer, Jaap; Palou, Andreu; Romaguera, Dora; van Schothorst, Evert M; Oliver, Paula.
+Institution
+ Costa, Andrea. Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) group, University of the Balearic Islands (UIB), Palma, Mallorca, 07122, Spain.
+ Costa, Andrea. Health Research Institute of the Balearic Islands (IdISBa), Palma, Mallorca, 07010, Spain.
+ Costa, Andrea. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ van der Stelt, Inge. Human and Animal Physiology, Wageningen University, Wageningen, 6708, The Netherlands.
+ Reynes, Barbara. Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) group, University of the Balearic Islands (UIB), Palma, Mallorca, 07122, Spain.
+ Reynes, Barbara. Health Research Institute of the Balearic Islands (IdISBa), Palma, Mallorca, 07010, Spain.
+ Reynes, Barbara. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ Konieczna, Jadwiga. Health Research Institute of the Balearic Islands (IdISBa), Palma, Mallorca, 07010, Spain.
+ Konieczna, Jadwiga. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ Konieczna, Jadwiga. Research Group on Nutritional Epidemiology & Cardiovascular Physiopathology (NUTRECOR), University Hospital Son Espases (HUSE), Palma, Mallorca, 07120, Spain.
+ Fiol, Miquel. Health Research Institute of the Balearic Islands (IdISBa), Palma, Mallorca, 07010, Spain.
+ Fiol, Miquel. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ Fiol, Miquel. Research Group on Nutritional Epidemiology & Cardiovascular Physiopathology (NUTRECOR), University Hospital Son Espases (HUSE), Palma, Mallorca, 07120, Spain.
+ Keijer, Jaap. Human and Animal Physiology, Wageningen University, Wageningen, 6708, The Netherlands.
+ Palou, Andreu. Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) group, University of the Balearic Islands (UIB), Palma, Mallorca, 07122, Spain.
+ Palou, Andreu. Health Research Institute of the Balearic Islands (IdISBa), Palma, Mallorca, 07010, Spain.
+ Palou, Andreu. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ Romaguera, Dora. Health Research Institute of the Balearic Islands (IdISBa), Palma, Mallorca, 07010, Spain.
+ Romaguera, Dora. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ Romaguera, Dora. Research Group on Nutritional Epidemiology & Cardiovascular Physiopathology (NUTRECOR), University Hospital Son Espases (HUSE), Palma, Mallorca, 07120, Spain.
+ van Schothorst, Evert M. Human and Animal Physiology, Wageningen University, Wageningen, 6708, The Netherlands.
+ Oliver, Paula. Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) group, University of the Balearic Islands (UIB), Palma, Mallorca, 07122, Spain.
+ Oliver, Paula. Health Research Institute of the Balearic Islands (IdISBa), Palma, Mallorca, 07010, Spain.
+ Oliver, Paula. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.
+MeSH Subject Headings
+ Humans
+ Overweight/me [Metabolism]
+ *Overweight
+ Leukocytes, Mononuclear/me [Metabolism]
+ *Leukocytes, Mononuclear
+ Transcriptome
+ Obesity/me [Metabolism]
+ Biomarkers
+ Gene Expression Profiling
+ Body Mass Index
+Keyword Heading
+ biomarkers
+ metabolic risk
+ normal-weight obesity
+ obesity
+ peripheral blood mononuclear cells
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ SCOPE: Peripheral blood mononuclear cells (PBMC) provide a useful and minimally invasive source of biomarkers. Here to identify PBMC transcriptomic biomarkers predictive of metabolic impairment related to increased adiposity is aimed.
+
+ METHODS AND RESULTS: The study analyzed the global PBMC transcriptome in metabolically healthy (normoglycemic) volunteers with overweight-obesity (OW-OB, n = 12), and in subjects with metabolically obese normal-weight (MONW, n = 5) phenotype, in comparison to normal-weight (NW, n = 12) controls. The study identifies 1072 differentially expressed genes (DEGs) in OW-OB versus NW and 992 in MONW versus NW. Hierarchical clustering of the top 100 DEGs clearly distinguishes OW-OB and MONW from NW. Remarkably, the OW-OB and MONW phenotypes share 257 DEGs regulated in the same direction. The top up-regulated gene CXCL8, coding for interleukin 8, with a role in obesity-related pathologies, is of special interest as a potential marker for predicting increased metabolic risk. CXCL8 expression is increased mainly in the MONW group and correlated directly with C-reactive protein levels.
+
+ CONCLUSIONS: PBMC gene expression analysis of CXCL8 or a pool of DEGs may be used to identify early metabolic risk in an apparently healthy population regardless of their BMI, i.e., subjects with OW-OB or MONW phenotype and to apply adequate and personalized nutritional preventive strategies. Copyright © 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2fmnfr.202200503
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Costa&issn=1613-4125&title=Molecular+Nutrition+%26+Food+Research&atitle=Whole-Genome+Transcriptomics+of+PBMC+to+Identify+Biomarkers+of+Early+Metabolic+Risk+in+Apparently+Healthy+People+with+Overweight-Obesity+and+in+Normal-Weight+Subjects.&volume=67&issue=4&spage=e2200503&epage=&date=2023&doi=10.1002%2Fmnfr.202200503&pmid=36564895&sid=OVID:medline
+
+<321>
+Unique Identifier
+ 36563436
+Title
+ Abdominal adiposity as a prognosis biomarker of clinical outcome in metastatic colorectal cancer.
+Source
+ Nutrition. 107:111913, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Oikawa KH; Juliani FL; Carrilho LAO; Pozzuto L; Padilha DMH; Silveira MN; Costa FO; Macedo LT; da Cunha Junior AD; Mendes MCS; Carvalheira JBC
+Authors Full Name
+ Oikawa, Karina Hiromoto; Juliani, Fabiana Lascala; Carrilho, Larissa Ariel Oliveira; Pozzuto, Lara; Padilha, Daniela Morais de Hollanda; Silveira, Marina Nogueira; Costa, Felipe Osorio; Macedo, Ligia Traldi; da Cunha Junior, Ademar Dantas; Mendes, Maria Carolina Santos; Carvalheira, Jose Barreto Campello.
+Institution
+ Oikawa, Karina Hiromoto. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ Juliani, Fabiana Lascala. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ Carrilho, Larissa Ariel Oliveira. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ Pozzuto, Lara. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ Padilha, Daniela Morais de Hollanda. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ Silveira, Marina Nogueira. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ Costa, Felipe Osorio. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ Macedo, Ligia Traldi. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ da Cunha Junior, Ademar Dantas. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil; Hematology and Oncology Clinics, Cancer Hospital of Cascavel, Uniao Oeste de Estudos e Combate ao Cancer (UOPECCAN), Cascavel, Brazil; Department of Internal Medicine, State University of Western Parana (UNIOESTE), Cascavel, Brazil.
+ Mendes, Maria Carolina Santos. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
+ Carvalheira, Jose Barreto Campello. Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil. Electronic address: jbcc@unicamp.br.
+MeSH Subject Headings
+ Humans
+ *Adiposity
+ Prognosis
+ Obesity
+ Subcutaneous Fat/dg [Diagnostic Imaging]
+ Obesity, Abdominal/co [Complications]
+ Obesity, Abdominal/dg [Diagnostic Imaging]
+ *Colonic Neoplasms
+ Biomarkers
+ Intra-Abdominal Fat/dg [Diagnostic Imaging]
+Keyword Heading
+ Adipose tissue
+ Body composition
+ Colorectal cancer
+ Computed tomography
+ Mortality
+ Obesity paradox
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Adipose tissue distribution and radiodensity are associated with prognosis in many types of cancer. However, the roles of adipose tissue distribution and radiodensity in patients with metastatic colorectal cancer (mCRC) remain unclear. The aim of this study was to assess the prognostic effect of adiposity and adipose tissue radiodensities in patients with mCRC.
+
+ METHODS: Patients with mCRC who received first-line palliative chemotherapy and had a computed tomography (CT) scan at the third lumbar vertebra (L3) level, admitted between January 2010 and December 2018, were sequentially enrolled. Body composition was assessed using CT-derived measurements. Univariate and multivariate logistic regression analyses and Kaplan-Meier curves were used to determine prognostic values.
+
+ RESULTS: The study included 237 patients. Cox analyses demonstrated that high subcutaneous adipose tissue (SAT) index was associated with a lower risk for death (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.29-0.88; Ptrend < 0.025). There was no significant association between visceral adipose tissue (VAT) index tertiles and overall survival. However, high VAT and SAT radiodensities were significantly associated with increased mortality (HR, 1.80; 95% CI, 1.12-2.89; Ptrend < 0.030 and HR, 1.85; 95% CI, 1.19-2.86; Ptrend < 0.021, respectively).
+
+ CONCLUSIONS: A higher SAT index in patients with mCRC was associated with a favorable overall survival outcome, whereas higher SAT and VAT radiodensities were associated with an increased risk for death, supporting that early nutritional intervention may improve mCRC prognosis. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.nut.2022.111913
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Oikawa&issn=0899-9007&title=Nutrition&atitle=Abdominal+adiposity+as+a+prognosis+biomarker+of+clinical+outcome+in+metastatic+colorectal+cancer.&volume=107&issue=&spage=111913&epage=&date=2023&doi=10.1016%2Fj.nut.2022.111913&pmid=36563436&sid=OVID:medline
+
+<322>
+Unique Identifier
+ 36562831
+Title
+ Effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women: a pilot study.
+Source
+ European Journal of Clinical Pharmacology. 79(2):299-309, 2023 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ El-Attar AA; Ibrahim OM; Alhassanin SA; Essa ES; Mostafa TM
+Author NameID
+ El-Attar, Aya Ahmed; ORCID: http://orcid.org/0000-0002-2274-4030
+ Ibrahim, Osama Mohamed; ORCID: http://orcid.org/0000-0002-2775-350X
+ Essa, Enas Said; ORCID: http://orcid.org/0000-0001-5749-3289
+ Mostafa, Tarek Mohamed; ORCID: http://orcid.org/0000-0003-1071-5416
+Authors Full Name
+ El-Attar, Aya Ahmed; Ibrahim, Osama Mohamed; Alhassanin, Suzan Ahmed; Essa, Enas Said; Mostafa, Tarek Mohamed.
+Institution
+ El-Attar, Aya Ahmed. Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt. aya.elattar@pharm.tanta.edu.eg.
+ Ibrahim, Osama Mohamed. Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.
+ Alhassanin, Suzan Ahmed. Department of Oncology and Nuclear Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
+ Essa, Enas Said. Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
+ Mostafa, Tarek Mohamed. Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.
+MeSH Subject Headings
+ Female
+ Humans
+ Letrozole/tu [Therapeutic Use]
+ Breast Neoplasms/dt [Drug Therapy]
+ Breast Neoplasms/pa [Pathology]
+ *Breast Neoplasms
+ Metformin/tu [Therapeutic Use]
+ *Metformin
+ Leptin
+ Estradiol/tu [Therapeutic Use]
+ Pilot Projects
+ Overweight/co [Complications]
+ Overweight/dt [Drug Therapy]
+ Blood Glucose
+ Postmenopause
+ Retrospective Studies
+ Osteocalcin/tu [Therapeutic Use]
+ Obesity/dt [Drug Therapy]
+ Insulin
+ Biomarkers
+Keyword Heading
+ Breast cancer
+ Estradiol
+ Leptin
+ Letrozole
+ Metformin
+ Osteocalcin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Metformin may provide a therapeutic benefit in different types of malignancy.
+
+ PURPOSE: We aimed at evaluating the effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women.
+
+ METHODS: Seventy-five postmenopausal stages II-III breast cancer female patients were assessed for eligibility in an open-labeled parallel pilot study. Forty-five patients met the inclusion criteria and were assigned into three arms: the lean arm (n = 15) women who received letrozole 2.5 mg/day, the control arm (n = 15) overweight/obese women who received letrozole 2.5 mg/day, and the metformin arm (n = 15) overweight/obese women who received letrozole 2.5 mg/day plus metformin (2000 +/- 500 mg/day). The intervention duration was 6 months. Blood samples were obtained at baseline and 6 months after intervention for the measurement of serum estradiol, leptin, osteocalcin levels, fasting blood glucose concentration, and serum insulin.
+
+ RESULTS: After the intervention and as compared to the control arm, the metformin arm showed a significantly lower ratio to the baseline (significant reduction) for estradiol (p = 0.0433), leptin (p < 0.0001), fasting blood glucose (p = 0.0128), insulin (p = 0.0360), osteocalcin serum levels (p < 0.0001), and the homeostatic model assessment of insulin resistance "HOMA-IR" value (p = 0.0145). There was a non-significant variation in the lactate ratio to the baseline among the three study arms (p = 0.5298).
+
+ CONCLUSION: Metformin may exert anti-cancer activity by decreasing the circulating estradiol, leptin, and insulin. Metformin might represent a safe and promising adjuvant therapy to letrozole in overweight/obese postmenopausal women with breast cancer.
+
+ TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05053841/Registered September 23, 2021 - Retrospectively. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 7LKK855W8I (Letrozole). 9100L32L2N (Metformin). 0 (Leptin). 4TI98Z838E (Estradiol). 0 (Blood Glucose). 104982-03-8 (Osteocalcin). 0 (Insulin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs00228-022-03444-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=El-Attar&issn=0031-6970&title=European+Journal+of+Clinical+Pharmacology&atitle=Effect+of+metformin+as+an+adjuvant+therapy+to+letrozole+on+estradiol+and+other+biomarkers+involved+in+the+pathogenesis+of+breast+cancer+in+overweight+and+obese+postmenopausal+women%3A+a+pilot+study.&volume=79&issue=2&spage=299&epage=309&date=2023&doi=10.1007%2Fs00228-022-03444-6&pmid=36562831&sid=OVID:medline
+
+<323>
+Unique Identifier
+ 36549643
+Title
+ Effect of semaglutide on fatty liver disease biomarkers in patients with diabetes and obesity.
+Source
+ Revista Clinica Espanola. 223(3):134-143, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Carretero-Gomez J; Carrasco-Sanchez FJ; Fernandez-Rodriguez JM; Casado-Escribano P; Miramontes-Gonzalez JP; Segui-Ripoll JM; Ena J; Arevalo-Lorido JC
+Corporate Author
+ Diabetes, Obesity, and Nutrition Working Group of the Spanish Society of Internal Medicine (SEMI)
+Authors Full Name
+ Carretero-Gomez, Juana; Carrasco-Sanchez, Francisco Javier; Fernandez-Rodriguez, Jose Maria; Casado-Escribano, Pedro; Miramontes-Gonzalez, Jose Pablo; Segui-Ripoll, Jose Miguel; Ena, Javier; Arevalo-Lorido, Jose Carlos.
+Institution
+ Carretero-Gomez, Juana. Servicio de Medicina Interna, Hospital Universitario de Badajoz, Badajoz, Spain. Electronic address: juanicarretero@gmail.com.
+ Carrasco-Sanchez, Francisco Javier. Servicio de Medicina Interna, Hospital Universitario Juan Ramon Jimenez, Huelva, Spain.
+ Fernandez-Rodriguez, Jose Maria. Servicio de Medicina Interna, Hospital Universitario Ramon y Cajal, Madrid, Spain.
+ Casado-Escribano, Pedro. Servicio de Medicina Interna, Hospital Universitario La Princesa, Madrid, Spain.
+ Miramontes-Gonzalez, Jose Pablo. Servicio de Medicina Interna, Hospital Universitario Rio Hortega, Valladolid, IBSAL - Instituto de Investigaciones Biomedicas de Salamanca, Salamanca, Spain.
+ Segui-Ripoll, Jose Miguel. Servicio de Medicina Interna, Hospital Universitario San Juan de Alicante, Alicante, Spain.
+ Ena, Javier. Servicio de Medicina Interna, Hospital Universitario Marina Baixa Hospital, La Villajoyosa (Alicante), Spain.
+ Arevalo-Lorido, Jose Carlos. Servicio de Medicina Interna, Hospital Universitario de Badajoz, Badajoz, Spain.
+MeSH Subject Headings
+ Humans
+ Female
+ Middle Aged
+ Male
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Prospective Studies
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Biomarkers
+ *Insulin Resistance
+ Triglycerides
+ Fibrosis
+Keyword Heading
+ Biomarcadores
+ Biomarkers
+ Diabetes mellitus tipo 2
+ Diabetes mellitus type 2
+ Fibrosis
+ Higado graso no alcoholico
+ Non-alcoholic fatty liver disease
+ Perdida de peso
+ Semaglutida
+ Semaglutide
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: This work aims to assess the effect of weekly subcutaneous semaglutide on biomarkers of metabolic-associated fatty liver disease (MAFLD), namely the hepatic steatosis index (HSI) and the fibrosis-4 (FIB-4) index, at 24 weeks in outpatients attended to in internal medicine departments.
+
+ METHODS: This study analyzed patients in an ongoing, multicenter, prospective, pre-post, uncontrolled cohort registry that enrolls unique, consecutive patients with type 2 diabetes treated with weekly subcutaneous semaglutide. Steatosis/fibrosis were determined by HSI (<30 ruled out, >36 steatosis) and FIB-4 (<1.3 ruled out, >2.67 fibrosis), respectively.
+
+ RESULTS: The sample included 213 patients (46.9% women) with a median age of 64 (19) years. The median baseline body mass index and weight were 36.1 (8.4) kg/m2 and 98 (26.9) kg, respectively. A total of 99.9% had HSI values indicating steatosis, with a mean HSI of 47.9 (8.2). Additionally, 10.8% had fibrosis (FIB-4 > 2.67) and 42.72% had values in intermediate ranges (FIB-4 1.3-2.67). At 24 weeks, there was a significant reduction in HSI (-2.36 (95%CI 1.83-2.9) p < 0.00001) and FIB-4 (-0.075 (95%CI 0.015-0.14) p < 0.016), mainly related to declines in body weight, triglyceride levels, insulin resistance (estimated by the triglyceride-glucose index), and liver enzymes.
+
+ CONCLUSION: These results show that weekly subcutaneous semaglutide had a beneficial effect on liver steatosis that went beyond glucose control. Its effects were mainly related to weight loss, a decline in biomarkers, and improvements in insulin sensitivity. For many patients, early detection is essential for improving MAFLD outcomes and may allow for selecting the most efficient treatment options. Copyright © 2022. Published by Elsevier Espana, S.L.U.
+Registry Number/Name of Substance
+ 53AXN4NNHX (semaglutide). 0 (Biomarkers). 0 (Triglycerides).
+Publication Type
+ Multicenter Study. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.rceng.2022.12.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Carretero-Gomez&issn=2254-8874&title=Revista+Clinica+Espanola&atitle=Effect+of+semaglutide+on+fatty+liver+disease+biomarkers+in+patients+with+diabetes+and+obesity.&volume=223&issue=3&spage=134&epage=143&date=2023&doi=10.1016%2Fj.rceng.2022.12.001&pmid=36549643&sid=OVID:medline
+
+<324>
+Unique Identifier
+ 36545749
+Title
+ The effects of fatty acid-based dietary interventions on circulating bioactive lipid levels as intermediate biomarkers of health, cardiovascular disease, and cardiovascular disease risk factors: a systematic review and meta-analysis of randomized clinical trials.
+Source
+ Nutrition Reviews. 81(8):988-1033, 2023 07 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Calderon-Perez L; Companys J; Sola R; Pedret A; Valls RM
+Author NameID
+ Calderon-Perez, Lorena; ORCID: https://orcid.org/0000-0003-0766-0733
+ Companys, Judit; ORCID: https://orcid.org/0000-0003-1485-0818
+Authors Full Name
+ Calderon-Perez, Lorena; Companys, Judit; Sola, Rosa; Pedret, Anna; Valls, Rosa M.
+Institution
+ Calderon-Perez, Lorena. Eurecat, Centre Tecnologic de Catalunya, Unitat de Nutricio i Salut, Reus, Spain.
+ Companys, Judit. Eurecat, Centre Tecnologic de Catalunya, Unitat de Nutricio i Salut, Reus, Spain.
+ Sola, Rosa. Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut), Departament de Medicina i Cirurgia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain. Hospital Universitari Sant Joan de Reus, Reus, Spain.
+ Pedret, Anna. Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut), Departament de Medicina i Cirurgia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain.
+ Valls, Rosa M. Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut), Departament de Medicina i Cirurgia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain.
+MeSH Subject Headings
+ Humans
+ 1-Alkyl-2-acetylglycerophosphocholine Esterase
+ Biomarkers
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Fatty Acids
+ Obesity
+ Randomized Controlled Trials as Topic
+ Lipids/bl [Blood]
+ *Lipids
+Keyword Heading
+ cardiovascular disease
+ glycerophospholipids
+ lipoprotein-associated phospholipase A2
+ lysoglycerophospholipids
+ polyunsaturated fatty acids
+ sphingolipids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Dietary fatty acids (FAs), primarily n-3 polyunsaturated FAs, have been associated with enrichment of the circulating bioactive lipidome and changes in the enzymatic precursor lipoprotein-associated phospholipase A2 (Lp-PLA2) mass; however, the magnitude of this effect remains unclear.
+
+ OBJECTIVE: The aim of this systematic review and meta-analysis was to evaluate the effect of different dietary FAs on the bioactive lipid profile of healthy participants and those with cardiovascular disease (CVD) and CVD risk factors.
+
+ DATA SOURCES: PubMed, SCOPUS and the Cochrane Library databases were searched for relevant articles published between October 2010 and May 2022.
+
+ DATA EXTRACTION: Data were screened for relevance and then retrieved in full and evaluated for eligibility by 2 reviewers independently.
+
+ DATA ANALYSIS: The net difference in the bioactive lipid mean values between the endpoint and the baseline, and the corresponding SDs or SEs, were used for the qualitative synthesis. For the meta-analysis, a fixed-effects model was used.
+
+ RESULTS: Twenty-seven randomized clinical trials (representing >2560 participants) were included. Over 78% of the enrolled participants had >=1 associated CVD risk factor, whereas <22% were healthy. In the meta-analysis, marine n-3 supplements (dose range, 0.37-1.9 g/d) significantly increased pro-inflammatory lysophosphatidylcholines (lyso-PCs; for lyso-PC(16:0): mean, +0.52 [95% confidence interval (CI), 0.02-1.01] microM; for lyso-PC(18:0): mean, +0.58 [95%CI, 0.09-1.08] microM) in obese participants. Additionally, n-3 supplementation (1-5.56 g/d) decreased plasma Lp-PLA2 mass, a well-known inflammation marker, in healthy (-0.35 [95%CI, -0.59 to -0.10] ng/mL), dyslipidemic (-0.36 [95%CI, -0.47 to -0.25] ng/mL), and stable coronary artery disease participants (-0.52 [95%CI, -0.91 to -0.12] ng/mL).
+
+ CONCLUSIONS: Daily n-3 provided as EPA+DHA supplements and consumed from 1 to 6 months reduced plasma Lp-PLA2 mass in healthy participants and those with CVD and CVD risk factors, suggesting an anti-inflammatory effect. However, the saturated lyso-PC response to n-3 was impaired in obese participants.
+
+ SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42021218335. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ EC 3-1-1-47 (1-Alkyl-2-acetylglycerophosphocholine Esterase). 0 (Biomarkers). 0 (Fatty Acids). 0 (Lipids).
+Publication Type
+ Meta-Analysis. Systematic Review. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1093%2fnutrit%2fnuac101
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Calderon-Perez&issn=0029-6643&title=Nutrition+Reviews&atitle=The+effects+of+fatty+acid-based+dietary+interventions+on+circulating+bioactive+lipid+levels+as+intermediate+biomarkers+of+health%2C+cardiovascular+disease%2C+and+cardiovascular+disease+risk+factors%3A+a+systematic+review+and+meta-analysis+of+randomized+clinical+trials.&volume=81&issue=8&spage=988&epage=1033&date=2023&doi=10.1093%2Fnutrit%2Fnuac101&pmid=36545749&sid=OVID:medline
+
+<325>
+Unique Identifier
+ 36542145
+Title
+ The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression.
+Source
+ Amino Acids. 55(3):313-323, 2023 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elshorbagy A; Bastani NE; Lee-Odegard S; Ovrebo B; Haj-Yasein N; Svendsen K; Turner C; Refsum H; Vinknes KJ; Olsen T
+Authors Full Name
+ Elshorbagy, Amany; Bastani, Nasser E; Lee-Odegard, Sindre; Ovrebo, Bente; Haj-Yasein, Nadia; Svendsen, Karianne; Turner, Cheryl; Refsum, Helga; Vinknes, Kathrine J; Olsen, Thomas.
+Institution
+ Elshorbagy, Amany. Department of Pharmacology, University of Oxford, Oxford, UK.
+ Elshorbagy, Amany. Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
+ Bastani, Nasser E. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Postboks 1046, Oslo, Norway.
+ Lee-Odegard, Sindre. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Postboks 1046, Oslo, Norway.
+ Ovrebo, Bente. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Postboks 1046, Oslo, Norway.
+ Haj-Yasein, Nadia. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Postboks 1046, Oslo, Norway.
+ Svendsen, Karianne. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Postboks 1046, Oslo, Norway.
+ Svendsen, Karianne. The Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway.
+ Turner, Cheryl. Department of Pharmacology, University of Oxford, Oxford, UK.
+ Refsum, Helga. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Postboks 1046, Oslo, Norway.
+ Vinknes, Kathrine J. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Postboks 1046, Oslo, Norway.
+ Olsen, Thomas. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Postboks 1046, Oslo, Norway. thomas.olsen@medisin.uio.no.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adult
+ Humans
+ Female
+ Male
+ *Cysteine
+ *Sulfhydryl Compounds
+ Body Composition
+ Cystine
+ Adipose Tissue
+ Obesity
+ Fasting
+ Biomarkers
+ Lipids
+ Apolipoproteins B/ge [Genetics]
+ Glutathione
+ Gene Expression
+ Body Mass Index
+Keyword Heading
+ Aminothiols
+ Android/gynoid ratio
+ Low-molecular-weight thiols
+ Obesity
+ Sulfur amino acids
+ Truncal adiposity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ People with high plasma total cysteine (tCys) have higher fat mass and higher concentrations of the atherogenic apolipoprotein B (apoB). The disulfide form, cystine, enhanced human adipogenesis and correlated with total fat mass in a Middle-Eastern cohort. In 35 European adults with overweight (88.6% women) and with dual-X-ray absorptiometry measurements of regional fat, we investigated how cystine compared to other free disulfides in their association with total regional adiposity, plasma lipid and glucose biomarkers, and adipose tissue lipid enzyme mRNA (n = 19). Most total plasma homocysteine (tHcy) (78%) was protein-bound; 63% of total glutathione (tGSH) was reduced. tCys was 49% protein-bound, 30% mixed-disulfide, 15% cystine, and 6% reduced. Controlling for age and lean mass, cystine and total free cysteine were the fractions most strongly associated with android and total fat: 1% higher cystine predicted 1.97% higher android fat mass (95% CI 0.64, 3.31) and 1.25% (0.65, 2.98) higher total fat mass (both p = 0.005). A positive association between tCys and apoB (beta: 0.64%; 95% CI 0.17, 1.12%, p = 0.009) was apparently driven by free cysteine and cystine; cystine was also inversely associated with the HDL-associated apolipoprotein A1 (beta: -0.57%; 95% CI -0.96, -0.17%, p = 0.007). No independent positive associations with adiposity were noted for tGSH or tHcy fractions. Plasma cystine correlated with CPT1a mRNA (Spearman's r = 0.68, p = 0.001). In conclusion, plasma cystine-but not homocysteine or glutathione disulfides-is associated with android adiposity and an atherogenic plasma apolipoprotein profile. The role of cystine in human adiposity and cardiometabolic risk deserves investigation. ClinicalTrials.gov identifiers: NCT02647970 and NCT03629392. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ K848JZ4886 (Cysteine). 0 (Sulfhydryl Compounds). 48TCX9A1VT (Cystine). 0 (Biomarkers). 0 (Lipids). 0 (Apolipoproteins B). GAN16C9B8O (Glutathione).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs00726-022-03229-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elshorbagy&issn=0939-4451&title=Amino+Acids&atitle=The+association+of+fasting+plasma+thiol+fractions+with+body+fat+compartments%2C+biomarker+profile%2C+and+adipose+tissue+gene+expression.&volume=55&issue=3&spage=313&epage=323&date=2023&doi=10.1007%2Fs00726-022-03229-2&pmid=36542145&sid=OVID:medline
+
+<326>
+Unique Identifier
+ 36538912
+Title
+ Cardiometabolic profiles in children and adults with overweight and obesity and down syndrome.
+Source
+ American Journal of Medical Genetics. Part A. 191(3):813-822, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Oreskovic NM; Baumer NT; Di Camillo C; Cornachia M; Franklin C; Hart SJ; Kishnani PS; McCormick A; Milliken AL; Patsiogiannis V; Pawlowski KG; Santoro SL; Sargado S; Scoppola V; Torres A; Valentini D; Vellody K; Villani A; Skotko BG
+Author NameID
+ Oreskovic, Nicolas M; ORCID: https://orcid.org/0000-0001-8702-8636
+ Hart, Sarah J; ORCID: https://orcid.org/0000-0003-0974-3209
+ Santoro, Stephanie L; ORCID: https://orcid.org/0000-0002-4172-0288
+Authors Full Name
+ Oreskovic, Nicolas M; Baumer, Nicole T; Di Camillo, Chiara; Cornachia, Michelle; Franklin, Catherine; Hart, Sarah J; Kishnani, Priya S; McCormick, Andrew; Milliken, Anna L; Patsiogiannis, Vasiliki; Pawlowski, Katherine G; Santoro, Stephanie L; Sargado, Sabrina; Scoppola, Vittorio; Torres, Amy; Valentini, Diletta; Vellody, Kishore; Villani, Alberto; Skotko, Brian G.
+Institution
+ Oreskovic, Nicolas M. Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Massachusetts General Hospital, Boston, Massachusetts, USA.
+ Oreskovic, Nicolas M. Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
+ Oreskovic, Nicolas M. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
+ Baumer, Nicole T. Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
+ Baumer, Nicole T. Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USA.
+ Di Camillo, Chiara. Pediatric Unit and Pediatric Emergency Department, Bambino Gesu Children's Hospital, Rome, Italy.
+ Cornachia, Michelle. Department of Internal Medicine, Geisinger Health System, Danville, Pennsylvania, USA.
+ Franklin, Catherine. Mater Research Institute, The University of Queensland, South Brisbane, Queensland, Australia.
+ Hart, Sarah J. Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.
+ Kishnani, Priya S. Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.
+ McCormick, Andrew. Down Syndrome Center of Western Pennsylvania, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
+ Milliken, Anna L. Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USA.
+ Patsiogiannis, Vasiliki. Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
+ Pawlowski, Katherine G. Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USA.
+ Santoro, Stephanie L. Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
+ Santoro, Stephanie L. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
+ Sargado, Sabrina. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
+ Sargado, Sabrina. Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USA.
+ Scoppola, Vittorio. Pediatric Unit and Pediatric Emergency Department, Bambino Gesu Children's Hospital, Rome, Italy.
+ Torres, Amy. Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
+ Valentini, Diletta. Pediatric Unit and Pediatric Emergency Department, Bambino Gesu Children's Hospital, Rome, Italy.
+ Vellody, Kishore. Down Syndrome Center of Western Pennsylvania, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
+ Villani, Alberto. Pediatric Unit and Pediatric Emergency Department, Bambino Gesu Children's Hospital, Rome, Italy.
+ Skotko, Brian G. Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
+ Skotko, Brian G. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
+MeSH Subject Headings
+ Humans
+ Child
+ Adult
+ Child, Preschool
+ Adolescent
+ Young Adult
+ Middle Aged
+ Overweight/co [Complications]
+ Overweight/ep [Epidemiology]
+ C-Reactive Protein/an [Analysis]
+ Down Syndrome/co [Complications]
+ Down Syndrome/ep [Epidemiology]
+ *Down Syndrome
+ Cross-Sectional Studies
+ Risk Factors
+ Obesity/co [Complications]
+ Body Mass Index
+ *Metabolic Diseases
+ Biomarkers
+ Lipids
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+Keyword Heading
+ Down syndrome
+ cardiometabolic
+ obesity
+ trisomy 21
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Individuals with Down syndrome (DS) are at increased risk for being overweight/obese, but the associated cardiometabolic risk (CR) is not clear. Cross-sectional anthropometric and clinical laboratory data from a multi-site, international cohort of individuals with DS were analyzed to determine cardiometabolic risk by reporting observed distributions of cardiometabolic biomarkers in overweight/obese individuals with DS throughout the lifespan. Descriptive statistics and regression analyses by age categories determined the distributive percentiles for cardiometabolic biomarkers and tested for adiposity as a predictor of CR. Across seven DS clinics, data were collected on 240 patients between the ages of 3 and 63 years, with one quarter overweight and three quarters obese among children and nearly all adults being obese. In children and adults, most cardiometabolic biomarker profiles showed distributive values within normal ranges. Blood lipids were positively associated with body mass index (BMI) in children (high density lipid-cholesterol, p = 0.01; low density lipid-cholesterol, p = 0.02). Levels of hs-CRP were elevated in both children and adults, with BMI positively associated with hs-CRP in adults with DS (p = 0.04). Liver enzyme values were positively associated with BMI in children and adults. The data suggest that in contrast to the general population, in individuals with Down syndrome, being overweight and obese does not appear to confer a significantly increased risk for cardiometabolic disease by biomarker profile. Individuals with DS who are overweight/obese appear to have unique cardiometabolic profiles unrelated to adiposity, notable for increased hs-CRP and normal HA1c levels. Copyright © 2022 Wiley Periodicals LLC.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1002%2fajmg.a.63088
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Oreskovic&issn=1552-4825&title=American+Journal+of+Medical+Genetics.+Part+A&atitle=Cardiometabolic+profiles+in+children+and+adults+with+overweight+and+obesity+and+down+syndrome.&volume=191&issue=3&spage=813&epage=822&date=2023&doi=10.1002%2Fajmg.a.63088&pmid=36538912&sid=OVID:medline
+
+<327>
+Unique Identifier
+ 36520252
+Title
+ Periconceptional biomarkers for maternal obesity: a systematic review. [Review]
+Source
+ Reviews in Endocrine & Metabolic Disorders. 24(2):139-175, 2023 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hojeij B; Rousian M; Sinclair KD; Dinnyes A; Steegers-Theunissen RPM; Schoenmakers S
+Author NameID
+ Hojeij, Batoul; ORCID: https://orcid.org/0000-0002-3262-0293
+ Rousian, Melek; ORCID: https://orcid.org/0000-0002-3008-2567
+ Sinclair, Kevin D; ORCID: https://orcid.org/0000-0002-6375-215X
+ Dinnyes, Andras; ORCID: https://orcid.org/0000-0003-3791-2583
+ Steegers-Theunissen, Regine P M; ORCID: https://orcid.org/0000-0002-4353-5756
+ Schoenmakers, Sam; ORCID: https://orcid.org/0000-0002-0316-6159
+Authors Full Name
+ Hojeij, Batoul; Rousian, Melek; Sinclair, Kevin D; Dinnyes, Andras; Steegers-Theunissen, Regine P M; Schoenmakers, Sam.
+Institution
+ Hojeij, Batoul. Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, 3015GD, The Netherlands.
+ Rousian, Melek. Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, 3015GD, The Netherlands.
+ Sinclair, Kevin D. School of Biosciences, Sutton Bonnington Campus, University of Nottingham, Leicestershire, LE12 6HD, UK.
+ Dinnyes, Andras. BioTalentum Ltd., Godollo, 2100, Hungary.
+ Dinnyes, Andras. Department of Cell Biology and Molecular Medicine, University of Szeged, Szeged, 6720, Hungary.
+ Dinnyes, Andras. Department of Physiology and Animal Health, Institute of Physiology and Animal Nutrition, Hungarian University of Agriculture and Life Sciences, Godollo, 2100, Hungary.
+ Steegers-Theunissen, Regine P M. Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, 3015GD, The Netherlands.
+ Schoenmakers, Sam. Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, 3015GD, The Netherlands. s.schoenmakers@erasmusmc.nl.
+MeSH Subject Headings
+ Infant, Newborn
+ Pregnancy
+ Humans
+ Female
+ *Leptin
+ C-Reactive Protein
+ *Obesity, Maternal
+ Adiponectin
+ Progesterone
+ Obesity
+ Biomarkers
+ Insulin
+ Chorionic Gonadotropin
+ Carbon
+Keyword Heading
+ Biomarker
+ Body mass index
+ Obesity
+ Periconceptional period
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Periconceptional maternal obesity is linked to adverse maternal and neonatal outcomes. Identifying periconceptional biomarkers of pathways affected by maternal obesity can unravel pathophysiologic mechanisms and identify individuals at risk of adverse clinical outcomes. The literature was systematically reviewed to identify periconceptional biomarkers of the endocrine, inflammatory and one-carbon metabolic pathways influenced by maternal obesity. A search was conducted in Embase, Ovid Medline All, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases, complemented by manual search in PubMed until December 31st, 2020. Eligible studies were those that measured biomarker(s) in relation to maternal obesity, overweight/obesity or body mass index (BMI) during the periconceptional period (14 weeks preconception until 14 weeks post conception). The ErasmusAGE score was used to assess the quality of included studies. Fifty-one articles were included that evaluated over 40 biomarkers. Endocrine biomarkers associated with maternal obesity included leptin, insulin, thyroid stimulating hormone, adiponectin, progesterone, free T4 and human chorionic gonadotropin. C-reactive protein was associated with obesity as part of the inflammatory pathway, while the associated one-carbon metabolism biomarkers were folate and vitamin B12. BMI was positively associated with leptin, C-reactive protein and insulin resistance, and negatively associated with Free T4, progesterone and human chorionic gonadotropin. Concerning the remaining studied biomarkers, strong conclusions could not be established due to limited or contradictory data. Future research should focus on determining the predictive value of the optimal set of biomarkers for their use in clinical settings. The most promising biomarkers include leptin, adiponectin, human chorionic gonadotropin, insulin, progesterone and CRP. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Leptin). 9007-41-4 (C-Reactive Protein). 0 (Adiponectin). 4G7DS2Q64Y (Progesterone). 0 (Biomarkers). 0 (Insulin). 0 (Chorionic Gonadotropin). 7440-44-0 (Carbon).
+Publication Type
+ Systematic Review. Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs11154-022-09762-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hojeij&issn=1389-9155&title=Reviews+in+Endocrine+%26+Metabolic+Disorders&atitle=Periconceptional+biomarkers+for+maternal+obesity%3A+a+systematic+review.&volume=24&issue=2&spage=139&epage=175&date=2023&doi=10.1007%2Fs11154-022-09762-5&pmid=36520252&sid=OVID:medline
+
+<328>
+Unique Identifier
+ 36494049
+Title
+ The association between adiposity and atypical energy-related symptoms of depression: A role for metabolic dysregulations.
+Source
+ Brain, Behavior, & Immunity. 108:197-203, 2023 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alshehri T; Mook-Kanamori DO; de Mutsert R; Penninx BW; Rosendaal FR; le Cessie S; Milaneschi Y
+Authors Full Name
+ Alshehri, Tahani; Mook-Kanamori, Dennis O; de Mutsert, Renee; Penninx, Brenda Wjh; Rosendaal, Frits R; le Cessie, Saskia; Milaneschi, Yuri.
+Institution
+ Alshehri, Tahani. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: t.m.alshehri@lumc.nl.
+ Mook-Kanamori, Dennis O. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
+ de Mutsert, Renee. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
+ Penninx, Brenda Wjh. Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
+ Rosendaal, Frits R. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
+ le Cessie, Saskia. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
+ Milaneschi, Yuri. Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
+MeSH Subject Headings
+ Humans
+ *Adiposity
+ Depression/ge [Genetics]
+ *Depression
+ Obesity/ge [Genetics]
+ Obesity/co [Complications]
+ Risk Factors
+ Biomarkers
+ Body Mass Index
+Keyword Heading
+ Body Fat Distribution
+ Body Mass Index
+ Depression
+ Genetic risk score
+ Homeostasis
+ Metabolic Syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Adiposity has been shown to be linked with atypical energy-related symptoms (AES) of depression. We used genomics to separate the effect of adiposity from that of metabolic dysregulations to examine whether the link between obesity and AES is dependent on the presence of metabolic dysregulations.
+
+ METHOD: Data were from NEO (n = 5734 individuals) and NESDA (n = 2238 individuals) cohorts, in which the Inventory of Depressive Symptomatology (IDS-SR30) was assessed. AES profile was based on four symptoms: increased appetite, increased weight, low energy level, and leaden paralysis. We estimated associations between AES and two genetic risk scores (GRS) indexing increasing total body fat with (metabolically unhealthy adiposity, GRS-MUA) and without (metabolically healthy adiposity, GRS-MHA) metabolic dysregulations.
+
+ RESULTS: We validated that both GRS-MUA and GRS-MHA were associated with higher total body fat in NEO study, but divergently associated with biomarkers of metabolic health (e.g., fasting glucose and HDL-cholesterol) in both cohorts. In the pooled results, per standard deviation, GRS-MUA was specifically associated with a higher AES score (beta = 0.03, 95%CI: 0.01; 0.05), while there was no association between GRS-MHA and AES (beta = -0.01, 95%CI: -0.03; 0.01).
+
+ CONCLUSION: These results suggest that the established link between adiposity and AES profile emerges in the presence of metabolic dysregulations, which may represent the connecting substrate between the two conditions. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.bbi.2022.12.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alshehri&issn=0889-1591&title=Brain%2C+Behavior%2C+%26+Immunity&atitle=The+association+between+adiposity+and+atypical+energy-related+symptoms+of+depression%3A+A+role+for+metabolic+dysregulations.&volume=108&issue=&spage=197&epage=203&date=2023&doi=10.1016%2Fj.bbi.2022.12.005&pmid=36494049&sid=OVID:medline
+
+<329>
+Unique Identifier
+ 36384192
+Title
+ Combined spectroscopic, biochemical and chemometric approach toward finding of biochemical markers of obesity.
+Source
+ Biochimica et Biophysica Acta - General Subjects. 1867(2):130279, 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Szczerbowska-Boruchowska M; Surowka AD; Ostachowicz B; Piana K; Spaleniak A; Wrobel P; Dudala J; Ziomber-Lisiak A
+Authors Full Name
+ Szczerbowska-Boruchowska, Magdalena; Surowka, Artur D; Ostachowicz, Beata; Piana, Kaja; Spaleniak, Anna; Wrobel, Pawel; Dudala, Joanna; Ziomber-Lisiak, Agata.
+Institution
+ Szczerbowska-Boruchowska, Magdalena. AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Al. Mickiewicza 30, Krakow 30-059, Poland. Electronic address: boruchowska@fis.agh.edu.pl.
+ Surowka, Artur D. AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Al. Mickiewicza 30, Krakow 30-059, Poland.
+ Ostachowicz, Beata. AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Al. Mickiewicza 30, Krakow 30-059, Poland.
+ Piana, Kaja. AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Al. Mickiewicza 30, Krakow 30-059, Poland.
+ Spaleniak, Anna. AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Al. Mickiewicza 30, Krakow 30-059, Poland.
+ Wrobel, Pawel. AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Al. Mickiewicza 30, Krakow 30-059, Poland.
+ Dudala, Joanna. AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Al. Mickiewicza 30, Krakow 30-059, Poland.
+ Ziomber-Lisiak, Agata. Department of Pathophysiology, Jagiellonian University, Medical College, Krakow, Poland.
+MeSH Subject Headings
+ Animals
+ *Chemometrics
+ Obesity/pc [Prevention & Control]
+ *Trace Elements
+ Spectrum Analysis
+ Biomarkers
+Keyword Heading
+ Chemical elements
+ Chemometrics
+ External ear
+ Obesity
+ Rat
+ Total reflection X-ray fluorescence
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Early-stage detection of subclinical obesity-driven systemic changes is a challenging area of medical diagnostics, where the most popular existing measures - such as body mass index - BMI - often fall short of providing a realistic estimate of adiposity and, therefore, of ongoing pathologies at the systemic, tissue and cellular level. In the quest for identifying new more robust diagnostic markers, whole-organ analysis of chemical elements is a promising approach for identifying candidate proxies of obesity status in the system.
+
+ METHODS: Total Reflection X-ray fluorescence (TXRF) coupled with biochemical assays, chemometrics and statistical validation was used as a new integrated pipeline for marker identification in external ear samples of obese animals. The specimens were taken from obese animals fed a high calorie diet as well as from lean intact animals fed a standard diet.
+
+ RESULTS: The most significant differences in the content of K, Fe, Br, and Rb between the studied groups of the animals were identified. However, with the methodology applied Rb was found the most robust biochemical discriminator of early-stage obesity effects, as validated by the logistic regression model. We observed no relationship between the levels of the elements consumed by the animals and their apparent content in the earlobe tissue samples.
+
+ CONCLUSIONS: Our preliminary study confirms that obesity alters tissue trace metal metabolism and shows the proposed new approach as an accurate and reliable methodology for detecting tissue elemental obesity-related alterations.
+
+ GENERAL SIGNIFICANCE: This result can be of practical significance for designing new point-of-care systems for obesity screening tests, taking advantage of direct/indirect Rb measurements. Copyright © 2022 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Trace Elements). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.bbagen.2022.130279
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Szczerbowska-Boruchowska&issn=0304-4165&title=Biochimica+et+Biophysica+Acta+-+General+Subjects&atitle=Combined+spectroscopic%2C+biochemical+and+chemometric+approach+toward+finding+of+biochemical+markers+of+obesity.&volume=1867&issue=2&spage=130279&epage=&date=2023&doi=10.1016%2Fj.bbagen.2022.130279&pmid=36384192&sid=OVID:medline
+
+<330>
+Unique Identifier
+ 36376521
+Title
+ Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study.
+Source
+ European Journal of Pediatrics. 182(1):419-429, 2023 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gonzalez-Gil EM; Anguita-Ruiz A; Kalen A; De Las Lamas Perez C; Ruperez AI; Vazquez-Cobela R; Flores K; Gil A; Gil-Campos M; Bueno G; Leis R; Aguilera CM
+Authors Full Name
+ Gonzalez-Gil, Esther M; Anguita-Ruiz, Augusto; Kalen, Anton; De Las Lamas Perez, Carmela; Ruperez, Azahara I; Vazquez-Cobela, Rocio; Flores, Katherine; Gil, Angel; Gil-Campos, Mercedes; Bueno, Gloria; Leis, Rosaura; Aguilera, Concepcion M.
+Institution
+ Gonzalez-Gil, Esther M. Department of Biochemistry and Molecular Biology II, Center of Biomedical Research (CIBM), Instituto de Nutricion Y Tecnologia de los Alimentos, Universidad de Granada, Granada, Spain.
+ Gonzalez-Gil, Esther M. GENUD (Growth, Exercise, NUtrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain.
+ Gonzalez-Gil, Esther M. CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.
+ Anguita-Ruiz, Augusto. Department of Biochemistry and Molecular Biology II, Center of Biomedical Research (CIBM), Instituto de Nutricion Y Tecnologia de los Alimentos, Universidad de Granada, Granada, Spain.
+ Anguita-Ruiz, Augusto. Instituto de Investigacion Biosanitaria IBS, Granada, Spain.
+ Kalen, Anton. Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
+ De Las Lamas Perez, Carmela. Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
+ Ruperez, Azahara I. GENUD (Growth, Exercise, NUtrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain.
+ Vazquez-Cobela, Rocio. CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.
+ Vazquez-Cobela, Rocio. Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
+ Flores, Katherine. Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain.
+ Gil, Angel. Department of Biochemistry and Molecular Biology II, Center of Biomedical Research (CIBM), Instituto de Nutricion Y Tecnologia de los Alimentos, Universidad de Granada, Granada, Spain.
+ Gil, Angel. CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.
+ Gil, Angel. Instituto de Investigacion Biosanitaria IBS, Granada, Spain.
+ Gil-Campos, Mercedes. CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.
+ Gil-Campos, Mercedes. Instituto de Investigacion Biosanitaria IBS, Granada, Spain.
+ Bueno, Gloria. GENUD (Growth, Exercise, NUtrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain.
+ Bueno, Gloria. CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.
+ Bueno, Gloria. Pediatric Endocrinology Unit, Facultad de Medicina, Clinic University Hospital Lozano Blesa, Universidad de Zaragoza, Zaragoza, 50009, Spain.
+ Leis, Rosaura. CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain. mariarosaura.leis@usc.es.
+ Leis, Rosaura. Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain. mariarosaura.leis@usc.es.
+ Aguilera, Concepcion M. Department of Biochemistry and Molecular Biology II, Center of Biomedical Research (CIBM), Instituto de Nutricion Y Tecnologia de los Alimentos, Universidad de Granada, Granada, Spain.
+ Aguilera, Concepcion M. CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.
+ Aguilera, Concepcion M. Instituto de Investigacion Biosanitaria IBS, Granada, Spain.
+MeSH Subject Headings
+ Child
+ Female
+ Humans
+ Adiponectin
+ Biomarkers
+ Body Mass Index
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Inflammation
+ *Insulin Resistance
+ Leptin
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome
+ Obesity/co [Complications]
+ Puberty
+ Male
+ Child, Preschool
+ Adolescent
+Keyword Heading
+ Cardiovascular risk
+ Inflammation
+ Metabolic syndrome
+ Puberty
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4-18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFalpha), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39-22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06-1.43).
+
+ CONCLUSION: Those with obesity with higher prepubertal tPAI plasma levels had 19% higher odds of having MetS at puberty highlighting the existence of association between MetS, obesity, and inflammation already in puberty. Thus, assessing cardiometabolic and inflammatory status in children with obesity already at prepuberty is key to avoiding future comorbidities.
+
+ WHAT IS KNOWN: * Inflammation, metabolic syndrome, and obesity may have their onset in childhood. * Puberty is a life stage characterized for an increased cardiovascular risk.
+
+ WHAT IS NEW: * Prepuberty state could be an early indicator of future cardiometabolic risk. * Children with obesity and high total plasminogen have higher odds of future metabolic syndrome. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs00431-022-04702-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gonzalez-Gil&issn=0340-6199&title=European+Journal+of+Pediatrics&atitle=Longitudinal+associations+between+cardiovascular+biomarkers+and+metabolic+syndrome+during+puberty%3A+the+PUBMEP+study.&volume=182&issue=1&spage=419&epage=429&date=2023&doi=10.1007%2Fs00431-022-04702-6&pmid=36376521&sid=OVID:medline
+
+<331>
+Unique Identifier
+ 36374935
+Title
+ Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention. [Review]
+Source
+ Journal of Clinical Endocrinology & Metabolism. 108(2):251-270, 2023 01 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Qi L; Chen Y
+Author NameID
+ Chen, Yongsheng; ORCID: https://orcid.org/0000-0001-8334-8034
+Authors Full Name
+ Qi, Li; Chen, Yongsheng.
+Institution
+ Qi, Li. Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China.
+ Chen, Yongsheng. Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
+MeSH Subject Headings
+ Humans
+ Bile Acids and Salts/bl [Blood]
+ Bile Acids and Salts/ch [Chemistry]
+ *Bile Acids and Salts
+ Biomarkers
+ Carcinoma, Hepatocellular/di [Diagnosis]
+ Carcinoma, Hepatocellular/et [Etiology]
+ *Carcinoma, Hepatocellular
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ *Insulin Resistance
+ Liver Neoplasms/di [Diagnosis]
+ *Liver Neoplasms
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+Keyword Heading
+ Alzheimer disease
+ bile acid
+ biomarker
+ hepatocellular carcinoma
+ nonalcoholic fatty liver disease
+ type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Bile acids (BAs) are pivotal signaling molecules that regulate energy metabolism and inflammation. Recent epidemiological studies have reported specific alterations in circulating BA profiles in certain disease states, including obesity, type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), and Alzheimer disease (AD). In the past decade, breakthroughs have been made regarding the translation of BA profiling into clinical use for disease prediction. In this review, we summarize and synthesize recent data on variation in circulating BA profiles in patients with various diseases to evaluate the value of these biomarkers in human plasma for early diagnosis.
+
+ EVIDENCE ACQUISITION: This review is based on a collection of primary and review literature gathered from a PubMed search for BAs, obesity, T2DM, insulin resistance (IR), NAFLD, hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), colon cancer, and AD, among other keywords.
+
+ EVIDENCE SYNTHESIS: Individuals with obesity, T2DM, HCC, CCA, or AD showed specific alterations in circulating BA profiles. These alterations may have existed long before the initial diagnosis of these diseases. The intricate relationship between obesity, IR, and NAFLD complicates the establishment of clear and independent associations between BA profiles and nonalcoholic steatohepatitis. Alterations in the levels of total BAs and several BA species were seen across the entire spectrum of NAFLD, demonstrating significant increases with the worsening of histological features.
+
+ CONCLUSIONS: Aberrant circulating BA profiles are an early event in the onset and progression of obesity, T2DM, HCC, and AD. The pleiotropic effects of BAs explain these broad connections. Circulating BA profiles could provide a basis for the development of biomarkers for the diagnosis and prevention of a wide range of diseases. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1210%2fclinem%2fdgac659
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Qi&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Circulating+Bile+Acids+as+Biomarkers+for+Disease+Diagnosis+and+Prevention.&volume=108&issue=2&spage=251&epage=270&date=2023&doi=10.1210%2Fclinem%2Fdgac659&pmid=36374935&sid=OVID:medline
+
+<332>
+Unique Identifier
+ 36350393
+Title
+ Abnormal [18F]FDG uptake in liver and adipose tissue: a potential imaging biomarker for cancer-associated cachexia.
+Source
+ European Radiology. 33(4):2561-2573, 2023 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jiang Y; Wu H; Zhao Y; Cui Y; Dai J; Huang S; Li C; Mao H; Ju S; Peng XG
+Author NameID
+ Peng, Xin-Gui; ORCID: http://orcid.org/0000-0003-2988-5984
+Authors Full Name
+ Jiang, Yang; Wu, Honghong; Zhao, Yufei; Cui, Ying; Dai, Jingyue; Huang, Shanshan; Li, Cheng; Mao, Hui; Ju, Shenghong; Peng, Xin-Gui.
+Institution
+ Jiang, Yang. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
+ Wu, Honghong. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
+ Zhao, Yufei. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
+ Cui, Ying. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
+ Dai, Jingyue. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
+ Huang, Shanshan. Department of Nuclear Medicine, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
+ Li, Cheng. Department of Nuclear Medicine, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
+ Mao, Hui. Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA.
+ Ju, Shenghong. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
+ Peng, Xin-Gui. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China. xingui2005peng@126.com.
+ Peng, Xin-Gui. Department of Radiology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, 211200, China. xingui2005peng@126.com.
+MeSH Subject Headings
+ Humans
+ *Fluorodeoxyglucose F18
+ Positron Emission Tomography Computed Tomography/mt [Methods]
+ Radiopharmaceuticals
+ Retrospective Studies
+ Neoplasms/co [Complications]
+ *Neoplasms
+ Biomarkers
+ Liver
+ Obesity
+ Weight Loss
+Keyword Heading
+ Adipose tissue
+ Cachexia
+ Fluorodeoxyglucose F18
+ Liver
+ Positron emission tomography-computed tomography
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: This study aims to investigate and develop imaging biomarkers for the diagnosis of cancer-associated cachexia based on the organ and tissue-specific abnormal metabolisms measured by fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT.
+
+ METHODS: FDG PET/CT data from 390 cancer patients were analyzed retrospectively. Patients were divided into a development cohort and a validation cohort. Cachexia was defined as weight loss > 5% in 6 months or BMI < 20 and weight loss > 2%. According to the above definitions, patients were divided into cachexia and non-cachexia groups. Results of the clinical laboratory tests for metabolic levels and organ and tissue-specific FDG uptake obtained from the cachexia and non-cachexia groups were compared statistically. Logistic regression analysis was performed to identify independent variables associated with cachexia in the development cohort for generating the regression model. The performance of the model was tested using the data from a validation cohort and evaluated by area under the receiver operating characteristic curve (AUC).
+
+ RESULTS: Based on the data from the development cohort of 286 patients and a validation cohort of 104 patients, it is found that age, white blood cell count, peak standardized uptake value (SUV) of the liver, and minimum SUV of lean body mass of visceral fat and subcutaneous fat were independently associated with cachexia. The model incorporating these variables reached an AUC of 0.777 (95% confidence interval (CI): 0.721, 0.833) in the development cohort and an AUC of 0.729 (95% CI: 0.629, 0.829) in the validation cohort.
+
+ CONCLUSION: Organ and tissue-specific abnormal glucose metabolism as measured by PET/CT can be used as a biomarker for cancer-associated cachexia.
+
+ KEY POINTS: * Patients with cancer-associated cachexia have reduced FDG uptake in the liver and increased FDG uptake in visceral fat and subcutaneous fat. * FDG uptake of the liver, visceral fat, and subcutaneous fat can be independent risk factors for identifying cancer-associated cachexia. * Cancer-associated cachexia can be classified using the model that incorporates age, white blood cell count, FDG uptake of the liver, and visceral and subcutaneous fat can diagnose with an AUC of 0.729. Copyright © 2022. The Author(s), under exclusive licence to European Society of Radiology.
+Registry Number/Name of Substance
+ 0Z5B2CJX4D (Fluorodeoxyglucose F18). 0 (Radiopharmaceuticals). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs00330-022-09226-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jiang&issn=0938-7994&title=European+Radiology&atitle=Abnormal+%5B18F%5DFDG+uptake+in+liver+and+adipose+tissue%3A+a+potential+imaging+biomarker+for+cancer-associated+cachexia.&volume=33&issue=4&spage=2561&epage=2573&date=2023&doi=10.1007%2Fs00330-022-09226-z&pmid=36350393&sid=OVID:medline
+
+<333>
+Unique Identifier
+ 36347450
+Title
+ Acute green tea intake attenuates circulating microRNA expression induced by a high-fat, high-saturated meal in obese women: A randomized crossover study.
+Source
+ Journal of Nutritional Biochemistry. 112:109203, 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bastos RVS; Dorna MS; Chiuso-Minicucci F; Felix TF; Fernandes AAH; Azevedo PS; Franco ET; Polegato BF; Rogero MM; Mota GAF; Quintanilha BJ; Paiva SAR; Zornoff LAM; Reis PP; Minicucci MF
+Authors Full Name
+ Bastos, Rodrigo V S; Dorna, Mariana S; Chiuso-Minicucci, Fernanda; Felix, Tainara F; Fernandes, Ana A H; Azevedo, Paula S; Franco, Estefania T; Polegato, Bertha F; Rogero, Marcelo M; Mota, Gustavo A F; Quintanilha, Bruna J; Paiva, Sergio A R; Zornoff, Leonardo A M; Reis, Patricia P; Minicucci, Marcos F.
+Institution
+ Bastos, Rodrigo V S. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Dorna, Mariana S. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Chiuso-Minicucci, Fernanda. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Felix, Tainara F. Experimental Research Unit, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Fernandes, Ana A H. Chemistry and Biochemistry Department, Institute of Biosciences, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Azevedo, Paula S. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Franco, Estefania T. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Polegato, Bertha F. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Rogero, Marcelo M. Department of Nutrition, School of Public Health, USP - University of Sao Paulo, Sao Paulo,Sao Paulo Brazil.
+ Mota, Gustavo A F. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Quintanilha, Bruna J. Department of Nutrition, School of Public Health, USP - University of Sao Paulo, Sao Paulo,Sao Paulo Brazil.
+ Paiva, Sergio A R. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Zornoff, Leonardo A M. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Reis, Patricia P. Experimental Research Unit, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil; Department of Surgery and Orthopedics, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
+ Minicucci, Marcos F. Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil. Electronic address: marcos.minicucci@unesp.br.
+MeSH Subject Headings
+ Humans
+ Female
+ Adult
+ Middle Aged
+ Adolescent
+ Circulating MicroRNA/ge [Genetics]
+ *Circulating MicroRNA
+ Cross-Over Studies
+ Tea
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ Obesity
+ Biomarkers
+Keyword Heading
+ Camellia sinensis
+ high-fat meal
+ inflammatory process
+ microRNA
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The objective of this study was to assess whether acute green tea (GT) supplementation attenuates inflammatory and oxidative stress biomarkers induced by high-fat, high-saturated (HFHS) meals in obese women, and to assess its ability to modulate circulating microRNA (miRNA) expression. This was a randomized, double-blind, crossover study. The study included obese women over 18 years old who had no comorbidities. In the first moment, patients were instructed to take 2 capsules of placebo or GT (738 mg) at 10:00 p.m. and to fast overnight. The next morning, a blood sample was collected, and an HFHS meal was offered to the patients. Another blood sample was collected 5 hours after the meal. In the second moment, patients who received placebo in the first moment now received the GT and vice-versa. Serum inflammatory and oxidative stress biomarkers were measured, and circulating levels of miRNA were evaluated. Fifteen women with mean age of 35.5+/-9.9 years were included in the final analysis. There was no difference regarding inflammatory and oxidative stress biomarkers. However, patients who consumed GT had lower circulating expression of 62 miRNAs compared with patients who did not consume GT. Predictive analysis of target genes showed 1,757 targets regulated by the 62 miRNAs. Notably, 5 miRNAs (miR-1297, miR-192-5p, miR-373-3p, miR-595 and miR-1266-5p) regulate genes associated with TGF-beta, CARM1, RSK, and BMP pathways. Our study showed that GT inhibited the expression of miRNAs induced by HFHS meal intake. These results shed light on the mechanisms involved in the beneficial effects of GT ingestion. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Circulating MicroRNA). 0 (Tea). 0 (MicroRNAs). 0 (Biomarkers). 0 (MIRN1297 microRNA, human).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.jnutbio.2022.109203
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bastos&issn=0955-2863&title=Journal+of+Nutritional+Biochemistry&atitle=Acute+green+tea+intake+attenuates+circulating+microRNA+expression+induced+by+a+high-fat%2C+high-saturated+meal+in+obese+women%3A+A+randomized+crossover+study.&volume=112&issue=&spage=109203&epage=&date=2023&doi=10.1016%2Fj.jnutbio.2022.109203&pmid=36347450&sid=OVID:medline
+
+<334>
+Unique Identifier
+ 36346274
+Title
+ Circulating microRNAs associated with gestational diabetes mellitus: useful biomarkers?. [Review]
+Source
+ Journal of Endocrinology. 256(1), 2023 01 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dinesen S; El-Faitarouni A; Dalgaard LT
+Author NameID
+ Dinesen, Sofie; ORCID: https://orcid.org/0000-0002-3718-5008
+ El-Faitarouni, Alisar; ORCID: https://orcid.org/0000-0002-0688-9053
+ Dalgaard, Louise T; ORCID: https://orcid.org/0000-0002-3598-2775
+Authors Full Name
+ Dinesen, Sofie; El-Faitarouni, Alisar; Dalgaard, Louise T.
+Institution
+ Dinesen, Sofie. Department of Science and Environment, Roskilde University, Universitetsvej 1, Roskilde, Denmark.
+ El-Faitarouni, Alisar. Department of Science and Environment, Roskilde University, Universitetsvej 1, Roskilde, Denmark.
+ Dalgaard, Louise T. Department of Science and Environment, Roskilde University, Universitetsvej 1, Roskilde, Denmark.
+MeSH Subject Headings
+ Pregnancy
+ Female
+ Humans
+ Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/ge [Genetics]
+ *Diabetes, Gestational
+ Circulating MicroRNA/ge [Genetics]
+ *Circulating MicroRNA
+ Biomarkers
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ Obesity
+Keyword Heading
+ biomarker
+ diagnostics
+ gestional diabetes mellitus
+ hyperglycemia
+ microRNA
+ screening
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Different types of small non-coding RNAs, especially miRNAs, may be found in the circulation, either protein-bound or enclosed in extracellular vesicles. During gestation, and particularly during gestational diabetes mellitus (GDM), the levels of several miRNAs are altered. Worldwide the incidence of GDM is increasing, in part driven by the current obesity epidemic. This is a point of public health concern because offspring of women with GDM frequently suffer from short- and long-term complications of maternal GDM. This has prompted the investigation of whether levels of specific miRNA species, detected early in gestation, may be used as diagnostic or prognostic markers for the development of GDM. Here, we summarize the mechanisms of RNA secretion and review circulating miRNAs associated with GDM. Several miRNAs are associated with GDM: miR-29a-3p and miR-29b-3p are generally upregulated in GDM pregnancies, also when measured prior to the development of GDM, while miR-16-5p is consistently upregulated in GDM pregnancies, especially in late gestation. miR-330-3p in circulation is increased in late gestation GDM women, especially in those with poor insulin secretion. miR-17-5p, miR-19a/b-3p, miR-223-3p, miR-155-5p, miR-125-a/b-5p, miR-210-3p and miR-132 are also associated with GDM, but less so and with more contradictory results reported. There could be a publication bias as miRNAs identified early are investigated the most, suggesting that it is likely that additional, more recently detected miRNAs could also be associated with GDM. Thus, circulating miRNAs show potential as biomarkers of GDM diagnosis or prognosis, especially multiple miRNAs containing prediction algorithms show promise, but further studies are needed.
+Registry Number/Name of Substance
+ 0 (Circulating MicroRNA). 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1530%2fJOE-22-0170
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dinesen&issn=0022-0795&title=Journal+of+Endocrinology&atitle=Circulating+microRNAs+associated+with+gestational+diabetes+mellitus%3A+useful+biomarkers%3F.&volume=256&issue=1&spage=&epage=&date=2023&doi=10.1530%2FJOE-22-0170&pmid=36346274&sid=OVID:medline
+
+<335>
+Unique Identifier
+ 36346108
+Title
+ Liver fat is superior to visceral and pancreatic fat as a risk biomarker of impaired glucose regulation in overweight/obese subjects.
+Source
+ Diabetes, Obesity & Metabolism. 25(3):716-725, 2023 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang M; Chen J; Yue J; He S; Fu J; Qi Y; Liu W; Xu H; Li S; Lu Q; Ma J
+Author NameID
+ Ma, Jing; ORCID: https://orcid.org/0000-0001-7369-2747
+Authors Full Name
+ Yang, Minglan; Chen, Jie; Yue, Jiang; He, Shenyun; Fu, Jingjing; Qi, Yicheng; Liu, Wen; Xu, Hua; Li, Shengxian; Lu, Qing; Ma, Jing.
+Institution
+ Yang, Minglan. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Chen, Jie. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Yue, Jiang. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ He, Shenyun. Department of Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Fu, Jingjing. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Qi, Yicheng. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Liu, Wen. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Xu, Hua. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Li, Shengxian. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Lu, Qing. Department of Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Ma, Jing. Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+MeSH Subject Headings
+ Humans
+ Overweight/me [Metabolism]
+ Glucose/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ *Insulin Resistance
+ Obesity/me [Metabolism]
+ Pancreas/me [Metabolism]
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus
+ Liver/me [Metabolism]
+ Abdomen/pa [Pathology]
+ Intra-Abdominal Fat/me [Metabolism]
+ Body Mass Index
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ impaired glucose regulation
+ liver fat content
+ obesity
+ pancreas fat content
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To investigate the distribution of abdominal fat, particularly ectopic fat accumulation, in relation to glucose metabolism in overweight/obese patients.
+
+ MATERIALS AND METHODS: This study included 257 overweight/obese subjects with body mass index >=23 kg/m2 . All the subjects underwent an oral glucose tolerance test. Magnetic resonance imaging-proton density fat fraction was used to measure fat accumulation in the liver, pancreas and abdomen. Impaired glucose regulation (IGR) was defined as the presence of prediabetes or diabetes.
+
+ RESULTS: Liver fat content (LFC) and visceral adipose tissue (VAT) were higher in overweight/obese subjects with diabetes than in those with normal glucose tolerance (NGT). No significant differences were observed in the pancreas fat content and subcutaneous fat area between subjects with NGT and IGR. LFC was an independent risk factor of IGR (odds ratio = 1.824 per standard deviation unit, 95% CI 1.242-2.679, p = .002). Compared with the lowest tertile of LFC, the multivariate-adjusted odds ratio for the prevalence of IGR in the highest tertile was 2.842 (95% CI 1.205-6.704). However, no association was observed between the VAT per standard deviation increment and tertiles after adjusting for multiple factors. For discordant visceral and liver fat phenotypes, the high LFC-low VAT and high LFC-high VAT groups had a higher prevalence of IGR than the low LFC-low VAT group. However, there was no difference in the prevalence of IGR between the low LFC-low VAT and low LFC-high VAT groups.
+
+ CONCLUSION: Compared with visceral and pancreatic fat content, LFC is a superior risk biomarker for IGR in overweight/obese subjects. Copyright © 2022 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1111%2fdom.14918
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=1462-8902&title=Diabetes%2C+Obesity+%26+Metabolism&atitle=Liver+fat+is+superior+to+visceral+and+pancreatic+fat+as+a+risk+biomarker+of+impaired+glucose+regulation+in+overweight%2Fobese+subjects.&volume=25&issue=3&spage=716&epage=725&date=2023&doi=10.1111%2Fdom.14918&pmid=36346108&sid=OVID:medline
+
+<336>
+Unique Identifier
+ 36344354
+Title
+ Liver fat accumulation more than fibrosis causes early liver dynamic dysfunction in patients with non-alcoholic fatty liver disease.
+Source
+ European Journal of Internal Medicine. 107:52-59, 2023 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Di Ciaula A; Shanmugam H; Ribeiro R; Pina A; Andrade R; Bonfrate L; Raposo JF; Macedo MP; Portincasa P
+Authors Full Name
+ Di Ciaula, Agostino; Shanmugam, Harshitha; Ribeiro, Rogerio; Pina, Ana; Andrade, Rita; Bonfrate, Leonilde; Raposo, Joao F; Macedo, M Paula; Portincasa, Piero.
+Institution
+ Di Ciaula, Agostino. Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Medical School, Piazza Giulio Cesare 11, Bari 70124, Italy.
+ Shanmugam, Harshitha. Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Medical School, Piazza Giulio Cesare 11, Bari 70124, Italy.
+ Ribeiro, Rogerio. Portuguese Diabetes Association-Education and Research Center (APDP-ERC), Lisbon 1150-082, Portugal.
+ Pina, Ana. iNOVA4Health, NOVA Medical School
+ Faculdade de Ciencias Medicas, NMS
+ FCM, Universidade Nova de Lisboa, Lisboa 1169-056, Portugal.
+ Andrade, Rita. Portuguese Diabetes Association-Education and Research Center (APDP-ERC), Lisbon 1150-082, Portugal.
+ Bonfrate, Leonilde. Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Medical School, Piazza Giulio Cesare 11, Bari 70124, Italy. Electronic address: leonilde.bonfrate@uniba.it.
+ Raposo, Joao F. iNOVA4Health, NOVA Medical School
+ Faculdade de Ciencias Medicas, NMS
+ FCM, Universidade Nova de Lisboa, Lisboa 1169-056, Portugal; Portuguese Diabetes Association-Education and Research Center (APDP-ERC), Lisbon 1150-082, Portugal.
+ Macedo, M Paula. iNOVA4Health, NOVA Medical School
+ Faculdade de Ciencias Medicas, NMS
+ FCM, Universidade Nova de Lisboa, Lisboa 1169-056, Portugal; Portuguese Diabetes Association-Education and Research Center (APDP-ERC), Lisbon 1150-082, Portugal.
+ Portincasa, Piero. Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Medical School, Piazza Giulio Cesare 11, Bari 70124, Italy. Electronic address: piero.portincasa@uniba.it.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ *Non-alcoholic Fatty Liver Disease
+ Overweight/co [Complications]
+ Overweight/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Liver/pa [Pathology]
+ Liver Cirrhosis
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Biomarkers
+Keyword Heading
+ Breath test
+ Fibroscan
+ Liver function
+ Liver steatosis
+ Liver stiffness
+ Metabolic-associated fatty liver disease
+ Non-alcoholic fatty liver disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: In Non-Alcoholic Fatty Liver Disease (NAFLD), events driving early hepatic dysfunction with respect to specific metabolic pathways are still poorly known.
+
+ METHODS: We enrolled 84 subjects with obesity and/or type 2 diabetes (T2D). FibroScan R served to assess NAFLD by controlled attenuation parameter (CAP), and fibrosis by liver stiffness (LS). Patients with LS above 7 kPa were excluded. APRI and FIB-4 were used as additional serum biomarkers of fibrosis. The stable-isotope dynamic breath test was used to assess the hepatic efficiency of portal extraction (as DOB15) and microsomal metabolization (as cPDR30) of orally-administered (13C)-methacetin.
+
+ RESULTS: NAFLD occurred in 45%, 65.9%, and 91.3% of normal weight, overweight, and obese subjects, respectively. Biomarkers of liver fibrosis were comparable across subgroups, and LS was higher in obese, than in normal weight subjects. DOB15 was 23.2 +/- 1.5 in normal weight subjects, tended to decrease in overweight (19.9 +/- 1.0) and decreased significantly in obese subjects (16.9 +/- 1.3, P = 0.008 vs. normal weight). Subjects with NAFLD had lower DOB15 (18.7 +/- 0.9 vs. 22.1 +/- 1.2, P = 0.03) but higher LS (4.7 +/- 0.1 vs. 4.0 +/- 0.2 kPa, P = 0.0003) than subjects without NAFLD, irrespective of fibrosis. DOB15 (but not cPDR30) decreased with increasing degree of NAFLD (R = -0.26; P = 0.01) and LS (R = -0.23, P = 0.03). Patients with T2D showed increased rate of NAFLD than those without T2D but similar LS, DOB15 and cPDR30.
+
+ CONCLUSIONS: Overweight, obesity and liver fat accumulation manifest with deranged portal extraction efficiency of methacetin into the steatotic hepatocyte. This functional alteration occurs early, and irrespective of significant fibrosis and presence of T2D. Copyright © 2022 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 13E468TFHP (methacetin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Comment.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.ejim.2022.10.024
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Di+Ciaula&issn=0953-6205&title=European+Journal+of+Internal+Medicine&atitle=Liver+fat+accumulation+more+than+fibrosis+causes+early+liver+dynamic+dysfunction+in+patients+with+non-alcoholic+fatty+liver+disease.&volume=107&issue=&spage=52&epage=59&date=2023&doi=10.1016%2Fj.ejim.2022.10.024&pmid=36344354&sid=OVID:medline
+
+<337>
+Unique Identifier
+ 36316116
+Title
+ Effect of Estimated Blood Volume and Body Mass Index on GFAP and NfL Levels in the Serum and CSF of Patients With Multiple Sclerosis.
+Source
+ Neurology neuroimmunology & neuroinflammation. 10(1), 2023 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yalachkov Y; Schafer JH; Jakob J; Friedauer L; Steffen F; Bittner S; Foerch C; Schaller-Paule MA
+Authors Full Name
+ Yalachkov, Yavor; Schafer, Jan Hendrik; Jakob, Jasmin; Friedauer, Lucie; Steffen, Falk; Bittner, Stefan; Foerch, Christian; Schaller-Paule, Martin Alexander.
+Institution
+ Yalachkov, Yavor. From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitatsmedizin Mainz, Germany. yavor.yalachkov@kgu.de.
+ Schafer, Jan Hendrik. From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitatsmedizin Mainz, Germany.
+ Jakob, Jasmin. From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitatsmedizin Mainz, Germany.
+ Friedauer, Lucie. From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitatsmedizin Mainz, Germany.
+ Steffen, Falk. From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitatsmedizin Mainz, Germany.
+ Bittner, Stefan. From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitatsmedizin Mainz, Germany.
+ Foerch, Christian. From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitatsmedizin Mainz, Germany.
+ Schaller-Paule, Martin Alexander. From the Department of Neurology (Y.Y., J.H.S., L.F., C.F., M.A.S.-P.), University Hospital Frankfurt; and Department of Neurology (J.J., F.S., S.B.), Universitatsmedizin Mainz, Germany.
+MeSH Subject Headings
+ Humans
+ Glial Fibrillary Acidic Protein
+ *Multiple Sclerosis
+ Intermediate Filaments
+ Body Mass Index
+ Overweight
+ Biomarkers
+ Blood Volume
+ Obesity
+Abstract
+ BACKGROUND AND OBJECTIVES: To increase the validity of biomarker measures in multiple sclerosis (MS), factors affecting their concentration need to be identified. Here, we test whether the volume of distribution approximated by the patients' estimated blood volume (BV) and body mass index (BMI) affect the serum concentrations of glial fibrillary acidic protein (GFAP). As a control, we also determine the relationship between BV/BMI and GFAP concentrations in CSF. To confirm earlier findings, we test the same hypotheses for neurofilament light chain (NfL).
+
+ METHODS: NfL and GFAP concentrations were measured in serum and CSF (sNFL/sGFAP and cNFL/cGFAP) in 157 patients (n = 106 with MS phenotype and n = 51 with other neurologic/somatoform diseases). Using multivariate linear regressions, BV was tested in the MS cohort as a predictor for each of the biomarkers while controlling for age, sex, MS phenotype, Expanded Disability Status Scale score, gadolinium-enhancing lesions, and acute relapse. In addition, overweight/obese patients (BMI >=25 kg/m2) were compared with patients with BMI <25 kg/m2 using the general linear model. The analyses were repeated including the neurologic/somatoform controls.
+
+ RESULTS: In the MS cohort, BV predicted sGFAP (s = -0.301, p = 0.014). Overweight/obese patients with MS had lower sGFAP concentrations compared with patients with MS and BMI <25 kg/m2 (F = 4.732, p = 0.032). Repeating the analysis after adding patients with other neurologic/somatoform diseases did not change these findings (s = -0.276, p = 0.009; F = 7.631, p = 0.006). Although sNfL was inversely correlated with BV (r = -0.275, p = 0.006) and body weight (r = -0.258, p = 0.010), those results did not remain significant after adjusting for covariates. BV and BMI were not associated with cGFAP or cNfL concentrations.
+
+ DISCUSSION: These findings support the notion that the volume of distribution of sGFAP approximated by BV and BMI is a relevant variable and should therefore be controlled for when measuring sGFAP in MS, while this might not be necessary when measuring cGFAP concentrations. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
+Registry Number/Name of Substance
+ 0 (Glial Fibrillary Acidic Protein). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1212%2fNXI.0000000000200045
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yalachkov&issn=2332-7812&title=Neurology+neuroimmunology+%26+neuroinflammation&atitle=Effect+of+Estimated+Blood+Volume+and+Body+Mass+Index+on+GFAP+and+NfL+Levels+in+the+Serum+and+CSF+of+Patients+With+Multiple+Sclerosis.&volume=10&issue=1&spage=&epage=&date=2023&doi=10.1212%2FNXI.0000000000200045&pmid=36316116&sid=OVID:medline
+
+<338>
+Unique Identifier
+ 36289132
+Title
+ Neurocognition as a biomarker in the rare autonomic disorders of CCHS and ROHHAD. [Review]
+Source
+ Clinical Autonomic Research. 33(3):217-230, 2023 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zelko FA; Welbel RZ; Rand CM; Stewart T; Fadl-Alla A; Khaytin I; Slattery SM; Weese-Mayer DE
+Author NameID
+ Zelko, Frank A; ORCID: http://orcid.org/0000-0003-3560-7323
+ Khaytin, Ilya; ORCID: http://orcid.org/0000-0001-8560-7730
+ Slattery, Susan M; ORCID: http://orcid.org/0000-0003-1894-0044
+ Weese-Mayer, Debra E; ORCID: http://orcid.org/0000-0001-6061-220X
+Authors Full Name
+ Zelko, Frank A; Welbel, Remi Z; Rand, Casey M; Stewart, Tracey; Fadl-Alla, Allaa; Khaytin, Ilya; Slattery, Susan M; Weese-Mayer, Debra E.
+Institution
+ Zelko, Frank A. Pritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children's Hospital of Chicago, Box 10B, 225 East Chicago, Chicago, IL, 60611, USA. fzelko@luriechildrens.org.
+ Zelko, Frank A. Northwestern University Feinberg School of Medicine, Chicago, IL, USA. fzelko@luriechildrens.org.
+ Welbel, Remi Z. Department of Pediatrics, Division of Autonomic Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
+ Rand, Casey M. Department of Pediatrics, Division of Autonomic Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
+ Stewart, Tracey. Department of Pediatrics, Division of Autonomic Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
+ Fadl-Alla, Allaa. Department of Pediatrics, Division of Autonomic Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
+ Khaytin, Ilya. Department of Pediatrics, Division of Autonomic Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
+ Slattery, Susan M. Department of Pediatrics, Division of Autonomic Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
+ Weese-Mayer, Debra E. Department of Pediatrics, Division of Autonomic Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, IL, USA.
+MeSH Subject Headings
+ Humans
+ Child
+ Child, Preschool
+ Hypoventilation/di [Diagnosis]
+ Hypoventilation/cn [Congenital]
+ Hypoventilation/ge [Genetics]
+ Obesity
+ Sleep Apnea, Central/ge [Genetics]
+ Sleep Apnea, Central/px [Psychology]
+ *Sleep Apnea, Central
+ *Autonomic Nervous System Diseases
+ Biomarkers
+Keyword Heading
+ Autonomic (dys)regulation
+ Cognition
+ Congenital central hypoventilation syndrome (CCHS)
+ PHOX2B
+ Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Congenital central hypoventilation syndrome (CCHS) and rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) are rare disorders of autonomic regulation with risk for disrupted neurocognitive development. Our aim is to summarize research on neurocognitive outcomes in these conditions, advance understanding of how to best support these individuals throughout development, and facilitate future research.
+
+ METHODS: We conducted a narrative review of literature on neurocognitive outcomes in CCHS and ROHHAD, supplemented with previously unpublished data from patients with CCHS and ROHHAD at our Center for Autonomic Medicine in Pediatrics (CAMP).
+
+ RESULTS: Individuals with CCHS and ROHHAD experience a wide range of neurocognitive functioning ranging from above average to below average, but are at particular risk for difficulties with working memory, processing speed, perceptual reasoning, and visuographic skills. An assessment framework emphasizing fluid cognition seems especially appropriate for these conditions. Owing to small cohorts and varied methods of data collection, it has been difficult to identify associations between disease factors (including CCHS PHOX2B genotypes) and cognitive outcomes. However, results suggest that early childhood is a period of particular vulnerability, perhaps due to the disruptive impact of recurrent intermittent hypoxic episodes on brain and cognitive development.
+
+ CONCLUSION: Neurocognitive monitoring is recommended as a component of routine clinical care in CCHS and ROHHAD as a marker of disease status and to ensure that educational support and disability accommodations are provided as early as possible. Collaborative efforts will be essential to obtain samples needed to enhance our understanding of neurocognitive outcomes in CCHS and ROHHAD. Copyright © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Rare Disease Supplementary Concept
+ Congenital central hypoventilation syndrome
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs10286-022-00901-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zelko&issn=0959-9851&title=Clinical+Autonomic+Research&atitle=Neurocognition+as+a+biomarker+in+the+rare+autonomic+disorders+of+CCHS+and+ROHHAD.&volume=33&issue=3&spage=217&epage=230&date=2023&doi=10.1007%2Fs10286-022-00901-1&pmid=36289132&sid=OVID:medline
+
+<339>
+Unique Identifier
+ 36170878
+Title
+ Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension.
+Source
+ Zeitschrift fur Geburtshilfe und Neonatologie. 227(1):42-50, 2023 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yarsilikal Guleroglu F; Selvi E; Turan Bakirci I; Bafali O; Argun Atalmis H; Yasti Dayan M; Balkan Ozmen A; Yurtcu N; Seker Atas B; Ozdemir Anayurt E; Cetin A
+Author NameID
+ Yarsilikal Guleroglu, Filiz; ORCID: https://orcid.org/0000-0003-4577-3368
+ Selvi, Esra; ORCID: https://orcid.org/0000-0003-0182-8988
+ Turan Bakirci, Isil; ORCID: https://orcid.org/0000-0003-1666-0452
+ Bafali, Olgu; ORCID: https://orcid.org/0000-0003-4133-2477
+ Argun Atalmis, Hatice; ORCID: https://orcid.org/0000-0003-0432-8786
+ Yasti Dayan, Merve; ORCID: https://orcid.org/0000-0002-5863-1986
+ Balkan Ozmen, Aliye; ORCID: https://orcid.org/0000-0003-1787-2692
+ Yurtcu, Nazan; ORCID: https://orcid.org/0000-0003-4725-043X
+ Seker Atas, Busra; ORCID: https://orcid.org/0000-0002-6190-3727
+ Ozdemir Anayurt, Esma; ORCID: https://orcid.org/0000-0002-0761-473X
+ Cetin, Ali; ORCID: https://orcid.org/0000-0002-5767-7894
+Authors Full Name
+ Yarsilikal Guleroglu, Filiz; Selvi, Esra; Turan Bakirci, Isil; Bafali, Olgu; Argun Atalmis, Hatice; Yasti Dayan, Merve; Balkan Ozmen, Aliye; Yurtcu, Nazan; Seker Atas, Busra; Ozdemir Anayurt, Esma; Cetin, Ali.
+Institution
+ Yarsilikal Guleroglu, Filiz. Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
+ Selvi, Esra. Department of Obstetrics and Gynecology, Basaksehir Cam ve Sakura City Hospital, Istanbul, Turkey.
+ Turan Bakirci, Isil. Department of Obstetrics and Gynecology, Bursa City Hospital, Bursa, Turkey.
+ Bafali, Olgu. Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
+ Argun Atalmis, Hatice. Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
+ Yasti Dayan, Merve. Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
+ Balkan Ozmen, Aliye. Department of Obstetrics and Gynecology, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey.
+ Yurtcu, Nazan. Department of Biochemistry, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
+ Seker Atas, Busra. Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
+ Ozdemir Anayurt, Esma. Department of Biochemistry, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
+ Cetin, Ali. Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
+MeSH Subject Headings
+ Pregnancy
+ Female
+ Humans
+ *Hypertension, Pregnancy-Induced
+ Pregnant Women
+ Growth Differentiation Factor 15
+ Matrix Metalloproteinase 9
+ Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/ep [Epidemiology]
+ *Diabetes, Gestational
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Biomarkers
+Abstract
+ AIMS: We evaluated the clinical value of selected serum biomarkers BMP-4, BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the comorbidities diabetes mellitus (DM) and gestational hypertension (GHT).
+
+ METHODS: This observational study had groups of controls, including healthy pregnant women; women with only obesity, including pregnant women with BMI>=30 kg/m2; women with gestational DM (GDM) with obesity, including pregnant women with GDM and obesity; women with pregestational DM (PGDM) with obesity, including pregnant women with PGDM and obesity; and women with GHT with obesity, including pregnant women with GHT and obesity. We measured serum levels of selected biomarkers by ELISA.
+
+ RESULTS: Obesity increased serum levels of all the biomarkers; GDM developed in obese women caused a more pronounced increase in the serum levels of BMP-4 and BMP-2, and GHT developed in obese women caused a more pronounced increase in the serum levels of GDF-15. In the women with GDM-, PGDM-, and GHT-complicated obesity, serum levels of MMP-9 and GP39 did not change meaningfully.
+
+ CONCLUSIONS: Obesity and its comorbidities DM and GHT lead to meaningful changes in the studied serum biomarkers. Since obesity has a causal effect on developing numerous conditions, reliable clinical biomarkers are needed to improve the early prediction and diagnosis of high-risk conditions during pregnancy. Copyright Thieme. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Growth Differentiation Factor 15). EC 3-4-24-35 (Matrix Metalloproteinase 9). 0 (Biomarkers).
+Publication Type
+ Observational Study. Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1055%2fa-1937-1155
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yarsilikal+Guleroglu&issn=0948-2393&title=Zeitschrift+fur+Geburtshilfe+und+Neonatologie&atitle=Clinical+Value+of+Serum+BMP-4%2C+BMP-2%2C+GDF-15%2C+MMP-9%2C+GP39+Levels+in+Pregnant+Women+with+Obesity+and+the+Related+Comorbidities+Diabetes+Mellitus+and+Gestational+Hypertension.&volume=227&issue=1&spage=42&epage=50&date=2023&doi=10.1055%2Fa-1937-1155&pmid=36170878&sid=OVID:medline
+
+<340>
+Unique Identifier
+ 36167704
+Title
+ Evaluation of sarcopenia biomarkers in older patients undergoing major surgery for digestive cancer. SAXO prospective cohort study.
+Source
+ European Journal of Surgical Oncology. 49(1):285-292, 2023 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gagnat G; Hobeika C; Modzelewski R; Collet CS; Di Fiore F; Druesne L; Tuech JJ; Schwarz L
+Authors Full Name
+ Gagnat, Guillaume; Hobeika, Christian; Modzelewski, Romain; Collet, Celine Savoye; Di Fiore, Frederic; Druesne, Laurent; Tuech, Jean Jacques; Schwarz, Lilian.
+Institution
+ Gagnat, Guillaume. Normandie Univ, UNIROUEN, Department of Digestive Surgery, Rouen University Hospital, Rouen, France.
+ Hobeika, Christian. Department of Hepatobiliary and Liver Transplantation Surgery, AP-HP, Hopital Pitie Salpetriere, CRSA, Sorbonne Universite, Paris, France.
+ Modzelewski, Romain. Normandie Univ, UNIROUEN, Quantif-LITIS EA, 4108, Rouen Cedex, France.
+ Collet, Celine Savoye. Normandie Univ, UNIROUEN, Quantif-LITIS EA, 4108, Rouen Cedex, France; Normandie Univ, UNIROUEN, Department of Radiology, Rouen University Hospital, Rouen, France.
+ Di Fiore, Frederic. Normandie Univ, UNIROUEN, Department of Digestive Oncology, Rouen University Hospital, Rouen, France; Normandie Univ, UNIROUEN, Inserm, 1245, IRON Group, Rouen Cedex, France.
+ Druesne, Laurent. Normandie Univ, UNIROUEN, Department of Geriatrics, Rouen University Hospital, Rouen, France.
+ Tuech, Jean Jacques. Normandie Univ, UNIROUEN, Department of Digestive Surgery, Rouen University Hospital, Rouen, France; Normandie Univ, UNIROUEN, Inserm, 1245, IRON Group, Rouen Cedex, France.
+ Schwarz, Lilian. Normandie Univ, UNIROUEN, Department of Digestive Surgery, Rouen University Hospital, Rouen, France; Normandie Univ, UNIROUEN, Inserm, 1245, IRON Group, Rouen Cedex, France. Electronic address: lilian.schwarz@gmail.com.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Humans
+ Aged
+ Sarcopenia/di [Diagnosis]
+ Sarcopenia/dg [Diagnostic Imaging]
+ *Sarcopenia
+ Hand Strength
+ Prospective Studies
+ Muscle, Skeletal/dg [Diagnostic Imaging]
+ Obesity/co [Complications]
+ Biomarkers
+ *Gastrointestinal Neoplasms
+Keyword Heading
+ Biomarkers
+ Myosteatosis
+ Sarcopenia
+ Surgical complication
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The aim of the study was to prospectively evaluate different biomarkers to identify the most reliable for anticipating complications after major abdominal surgery for digestive cancer in older patients and compare their performance to the existing definition and screening algorithm of sarcopenia from EWGSOP.
+
+ METHODS: Ninety-five consecutive patients aged over 65 years who underwent elective surgery for digestive cancer were prospectively included in the SAXO study. Sarcopenia was defined according to EWGSOP criteria (four level from no sarcopenia to severe sarcopenia). Strength and physical performance were evaluated with the handgrip test (HGT) and gait speed test (GST), respectively. CT scan analysis was used to calculate the skeletal muscle index (SMI), intermuscular adipose tissue (IMAT), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Measures were adjusted to body mass index (BMI). Complication grading was performed using the Clavien-Dindo classification. A doubly robust estimator with multivariable regression was used to limit bias.
+
+ RESULTS: Sixteen patients presented with sarcopenia. Adjusted to BMI, sarcopenic patients had an increased IMATBMI (0.35 vs. 0.22; p = 0.003) and increased VATBMI (7.85 vs. 6.13; p = 0.048). In multivariable analysis, IMAT was an independent risk factor for minor and severe complications (OR = 1.298; 95% CI [1.031: 1.635] p = 0.027), while an increased SAT area was a protective factor (OR = 0.982; 95% CI [0.969: 0.995] p = 0.007). Twenty-two patients were obese (BMI >=30 kg/m2). While no association was observed between obesity and sarcopenia (according to EWGSOP definition), obese patients had increased IMATBMI (0.31 vs. 0.23; p = 0.010) and VATBMI (8.40 vs. 6.49; p = 0.019). The combination of SAT, VAT and IMAT performed well to anticipate severe complication (AUC = 0.759) while AUC of EWGSOP 2010 and 2019 algorithm were 0.660 and 0.519, respectively.
+
+ DISCUSSION: Non-invasive and imaging related measures of IMAT, SAT and VAT seems to be valuable tools to refine risk-assessment of older patients in surgery and specially to detect myosteatosis in obese ones. Copyright © 2022. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Comment.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.ejso.2022.08.038
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gagnat&issn=0748-7983&title=European+Journal+of+Surgical+Oncology&atitle=Evaluation+of+sarcopenia+biomarkers+in+older+patients+undergoing+major+surgery+for+digestive+cancer.+SAXO+prospective+cohort+study.&volume=49&issue=1&spage=285&epage=292&date=2023&doi=10.1016%2Fj.ejso.2022.08.038&pmid=36167704&sid=OVID:medline
+
+<341>
+Unique Identifier
+ 36162568
+Title
+ Joint effect of multiple air pollutants on cardiometabolic health in normal-weight and obese adults: A novel insight into the role of circulating free fatty acids.
+Source
+ Science of the Total Environment. 856(Pt 1):159014, 2023 Jan 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang W; Wang W; Li L; Miller MR; Cui L; Liu J; Wang Y; Hu D; Liu S; Xu J; Wu S; Duan J; Sun Z; Guo X; Deng F
+Authors Full Name
+ Zhang, Wenlou; Wang, Wanzhou; Li, Luyi; Miller, Mark R; Cui, Liyan; Liu, Junxiu; Wang, Yang; Hu, Dayu; Liu, Shan; Xu, Junhui; Wu, Shaowei; Duan, Junchao; Sun, Zhiwei; Guo, Xinbiao; Deng, Furong.
+Institution
+ Zhang, Wenlou. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Wang, Wanzhou. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Li, Luyi. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Miller, Mark R. University/BHF Centre for Cardiovascular Science, Queens Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.
+ Cui, Liyan. Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.
+ Liu, Junxiu. Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing 100191, China.
+ Wang, Yang. Hospital of Health Science Center, Peking University, Beijing 100191, China.
+ Hu, Dayu. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Liu, Shan. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Xu, Junhui. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Wu, Shaowei. Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, Shaanxi 710061, China.
+ Duan, Junchao. Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China.
+ Sun, Zhiwei. Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China.
+ Guo, Xinbiao. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Deng, Furong. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China. Electronic address: lotus321321@126.com.
+MeSH Subject Headings
+ Adult
+ Humans
+ Air Pollutants/ae [Adverse Effects]
+ Air Pollutants/an [Analysis]
+ *Air Pollutants
+ Fatty Acids, Nonesterified
+ Particulate Matter/ae [Adverse Effects]
+ Particulate Matter/an [Analysis]
+ Bayes Theorem
+ Air Pollution/ae [Adverse Effects]
+ Air Pollution/an [Analysis]
+ *Air Pollution
+ Obesity/ep [Epidemiology]
+ Lipids/an [Analysis]
+ Biomarkers/an [Analysis]
+ Inflammation
+ *Cardiovascular Diseases
+Keyword Heading
+ De novo lipogenesis
+ Free fatty acids
+ Lipid profile
+ Obesity
+ Ozone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The cardiometabolic effects of air pollution in the context of mixtures and the underlying mechanisms remain not fully understood. This study aims to investigate the joint effect of air pollutant mixtures on a broad range of cardiometabolic parameters, examine the susceptibility of obese individuals, and determine the role of circulating fatty acids. In this panel study, metabolically healthy normal-weight (MH-NW, n = 49) and obese (MHO, n = 39) adults completed three longitudinal visits (257 person-visits in total). Personal exposure levels of PM2.5, PM10, O3, NO2, SO2, CO and BC were estimated based on fixed-site monitoring data, time-activity logs and infiltration factor method. Blood pressure, glycemic homeostasis, lipid profiles, systematic inflammation and coagulation biomarkers were measured. Targeted metabolomics was used to quantify twenty-eight plasma free fatty acids (FFAs). Bayesian kernel machine regression models were applied to establish the exposure-response relationships and identify key pollutants. Significant joint effects of measured air pollutants on systematic inflammation and coagulation biomarkers were observed in the MHO group, instead of the MH-NW group. Lipid profiles showed the most significant changes in both groups and O3 contributed the most to the total effect. Specific FFA patterns were identified, and de novo lipogenesis (DNL)-related pattern was most closely related to blood lipid profiles. In particular, interaction analysis suggested that DNL-related FFA pattern augmented the effects of O3 on triglyceride (TG, Pinteraction = 0.040), high-density lipoprotein cholesterol (HDL-C, Pinteraction = 0.106) and TG/HDL-C (Pinteraction = 0.020) in the MHO group but not MH-NW group. This modification was further confirmed by interaction analysis with estimated activity of SCD1, a key enzyme in the DNL pathway. Therefore, despite being metabolically healthy, obese subjects have a higher cardiometabolic susceptibility to air pollution, especially O3, and the DNL pathway may represent an intrinsic driver of lipid susceptibility. This study provides new insights into the cardiometabolic susceptibility of obese individuals to air pollution. Copyright © 2022 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Air Pollutants). 0 (Fatty Acids, Nonesterified). 0 (Particulate Matter). 0 (Lipids). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1016%2fj.scitotenv.2022.159014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=0048-9697&title=Science+of+the+Total+Environment&atitle=Joint+effect+of+multiple+air+pollutants+on+cardiometabolic+health+in+normal-weight+and+obese+adults%3A+A+novel+insight+into+the+role+of+circulating+free+fatty+acids.&volume=856&issue=1&spage=159014&epage=&date=2023&doi=10.1016%2Fj.scitotenv.2022.159014&pmid=36162568&sid=OVID:medline
+
+<342>
+Unique Identifier
+ 36059088
+Title
+ Effects of inulin supplementation on inflammatory biomarkers and clinical symptoms of women with obesity and depression on a calorie-restricted diet: a randomised controlled clinical trial.
+Source
+ British Journal of Nutrition. 129(11):1897-1907, 2023 06 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vaghef-Mehrabani E; Harouni R; Behrooz M; Ranjbar F; Asghari-Jafarabadi M; Ebrahimi-Mameghani M
+Author NameID
+ Vaghef-Mehrabani, Elnaz; ORCID: https://orcid.org/0000-0003-0890-2618
+ Ebrahimi-Mameghani, Mehrangiz; ORCID: https://orcid.org/0000-0002-0311-1289
+Authors Full Name
+ Vaghef-Mehrabani, Elnaz; Harouni, Roya; Behrooz, Maryam; Ranjbar, Fatemeh; Asghari-Jafarabadi, Mohammad; Ebrahimi-Mameghani, Mehrangiz.
+Institution
+ Vaghef-Mehrabani, Elnaz. Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.
+ Vaghef-Mehrabani, Elnaz. Department of Pediatrics, University of Calgary, Calgary, AB, Canada.
+ Vaghef-Mehrabani, Elnaz. Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Harouni, Roya. Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Behrooz, Maryam. Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Ranjbar, Fatemeh. Research Center of Psychiatry & Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Asghari-Jafarabadi, Mohammad. Cabrini Research, Cabrini Health, VIC3144, Australia.
+ Asghari-Jafarabadi, Mohammad. School of Public Health and Preventative Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, VIC3800, Australia.
+ Asghari-Jafarabadi, Mohammad. Road Traffic Injury Research Center, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Ebrahimi-Mameghani, Mehrangiz. Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+MeSH Subject Headings
+ Humans
+ Female
+ Inulin/pd [Pharmacology]
+ Inulin/tu [Therapeutic Use]
+ Brain-Derived Neurotrophic Factor
+ *Endotoxemia
+ *Depressive Disorder, Major
+ Caloric Restriction
+ Depression
+ Double-Blind Method
+ Biomarkers
+ Prebiotics
+ Obesity/co [Complications]
+Keyword Heading
+ Calorie restriction
+ Inflammation
+ Inulin
+ Major depressive disorder
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Major depressive disorder (MDD) is regarded as an inflammatory disorder. Gut microbiota dysbiosis, observed in both MDD and obesity, leads to endotoxemia and inflammatory status, eventually exacerbating depressive symptoms. Manipulation of gut microbiota by prebiotics might help alleviate depression. The present study aimed to investigate the effects of inulin supplementation on psychological outcomes and biomarkers of gut permeability, endotoxemia, inflammation, and brain-derived neurotrophic factor (BDNF) in women with obesity and depression on a calorie-restricted diet. In a double-blind randomised clinical trial, forty-five women with obesity and MDD were allocated to receive 10 g/d of either inulin or maltodextrin for 8 weeks; all the patients followed a healthy calorie restricted diet as well. Anthropometric measures, dietary intakes, depression, and serum levels of zonulin, lipopolysaccharide (LPS), inflammatory biomarkers (TNF-alpha, IL-10, monocyte chemoattractant protein-1, toll-like receptor-4 and high-sensitivity C-reactive protein), and BDNF were assessed at baseline and end of the study. Weight and Hamilton Depression Rating Scale (HDRS) scores decreased in both groups; between-group differences were non-significant by the end of study (P = 0.333 for body weight and P = 0.500 for HDRS). No between-group differences were observed for the other psychological outcomes and serum biomarkers (P > 0.05). In this short-term study, prebiotic supplementation had no significant beneficial effects on depressive symptoms, gut permeability, or inflammatory biomarkers in women with obesity and depression.
+Registry Number/Name of Substance
+ 9005-80-5 (Inulin). 0 (Brain-Derived Neurotrophic Factor). 0 (Biomarkers). 0 (Prebiotics).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1017%2fS000711452200232X
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vaghef-Mehrabani&issn=0007-1145&title=British+Journal+of+Nutrition&atitle=Effects+of+inulin+supplementation+on+inflammatory+biomarkers+and+clinical+symptoms+of+women+with+obesity+and+depression+on+a+calorie-restricted+diet%3A+a+randomised+controlled+clinical+trial.&volume=129&issue=11&spage=1897&epage=1907&date=2023&doi=10.1017%2FS000711452200232X&pmid=36059088&sid=OVID:medline
+
+<343>
+Unique Identifier
+ 36028609
+Title
+ Fibroblast growth factor 21 in heart failure. [Review]
+Source
+ Heart Failure Reviews. 28(1):261-272, 2023 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tucker W; Tucker B; Rye KA; Ong KL
+Author NameID
+ Tucker, Bradley; ORCID: https://orcid.org/0000-0002-7028-4331
+ Rye, Kerry-Anne; ORCID: https://orcid.org/0000-0002-9751-917X
+ Ong, Kwok Leung; ORCID: https://orcid.org/0000-0001-7229-7614
+Authors Full Name
+ Tucker, William; Tucker, Bradley; Rye, Kerry-Anne; Ong, Kwok Leung.
+Institution
+ Tucker, William. Lipid Research Group, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
+ Tucker, Bradley. Rural Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
+ Tucker, Bradley. Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
+ Rye, Kerry-Anne. Lipid Research Group, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
+ Ong, Kwok Leung. Lipid Research Group, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia. oklws@yahoo.com.hk.
+MeSH Subject Headings
+ Animals
+ Humans
+ *Heart Failure
+ Fibroblast Growth Factors
+ Biomarkers
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+Keyword Heading
+ Biomarker
+ Cardiomyocyte
+ Fibroblast growth factor 21
+ Heart failure
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Fibroblast growth factor 21 (FGF21) is a peptide hormone involved in energy homeostasis that protects against the development of obesity and diabetes in animal models. Its level is elevated in atherosclerotic cardiovascular diseases (CVD) in humans. However, little is known about the role of FGF21 in heart failure (HF). HF is a major global health problem with a prevalence that is predicted to rise, especially in ageing populations. Despite improved therapies, mortality due to HF remains high, and given its insidious onset, prediction of its development is challenging for physicians. The emergence of cardiac biomarkers to improve prediction, diagnosis, and prognosis of HF has received much attention over the past decade. Recent studies have suggested FGF21 is a promising biomarker candidate for HF. Preclinical research has shown that FGF21 is involved in the pathophysiology of HF through the prevention of oxidative stress, cardiac hypertrophy, and inflammation in cardiomyocytes. However, in the available clinical literature, FGF21 levels appear to be paradoxically raised in HF, potentially implying a FGF21 resistant state as occurs in obesity. Several potential confounding variables complicate the verdict on whether FGF21 is of clinical value as a biomarker. Further research is thus needed to evaluate whether FGF21 has a causal role in HF, and whether circulating FGF21 can be used as a biomarker to improve the prediction, diagnosis, and prognosis of HF. This review draws from preclinical and clinical studies to explore the role of FGF21 in HF. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs10741-022-10268-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tucker&issn=1382-4147&title=Heart+Failure+Reviews&atitle=Fibroblast+growth+factor+21+in+heart+failure.&volume=28&issue=1&spage=261&epage=272&date=2023&doi=10.1007%2Fs10741-022-10268-0&pmid=36028609&sid=OVID:medline
+
+<344>
+Unique Identifier
+ 36002514
+Title
+ Phase angle as biomarker of inflammatory changes during very low-calorie ketogenic diet.
+Source
+ International Journal of Obesity. 47(1):1-2, 2023 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Barrea L; Muscogiuri G; Savastano S
+Author NameID
+ Barrea, Luigi; ORCID: http://orcid.org/0000-0001-9054-456X
+ Muscogiuri, Giovanna; ORCID: http://orcid.org/0000-0002-8809-4931
+Authors Full Name
+ Barrea, Luigi; Muscogiuri, Giovanna; Savastano, Silvia.
+Institution
+ Barrea, Luigi. Dipartimento di Scienze Umanistiche, Universita Telematica Pegaso, Via Porzio, Centro Direzionale, Isola F2, 80143, Naples, Italy. luigi.barrea@unina.it.
+ Barrea, Luigi. Centro Italiano per la cura e il Benessere del paziente con Obesita (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy. luigi.barrea@unina.it.
+ Muscogiuri, Giovanna. Centro Italiano per la cura e il Benessere del paziente con Obesita (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.
+ Muscogiuri, Giovanna. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.
+ Savastano, Silvia. Centro Italiano per la cura e il Benessere del paziente con Obesita (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.
+ Savastano, Silvia. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.
+MeSH Subject Headings
+ Humans
+ *Diet, Ketogenic
+ Obesity
+ Ketone Bodies
+ Biomarkers
+ Caloric Restriction
+Registry Number/Name of Substance
+ 0 (Ketone Bodies). 0 (Biomarkers).
+Publication Type
+ Letter.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1038%2fs41366-022-01201-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Barrea&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Phase+angle+as+biomarker+of+inflammatory+changes+during+very+low-calorie+ketogenic+diet.&volume=47&issue=1&spage=1&epage=2&date=2023&doi=10.1038%2Fs41366-022-01201-4&pmid=36002514&sid=OVID:medline
+
+<345>
+Unique Identifier
+ 35982289
+Title
+ Associations between cardiometabolic phenotypes and levels of TNF-alpha, CRP, and interleukins in obstructive sleep apnea.
+Source
+ Sleep & Breathing. 27(3):1033-1042, 2023 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fei Q; Tan Y; Yi M; Zhao W; Zhang Y
+Author NameID
+ Zhang, Yuan; ORCID: https://orcid.org/0000-0003-0577-7129
+Authors Full Name
+ Fei, Quanming; Tan, Yun; Yi, Minhan; Zhao, Wangcheng; Zhang, Yuan.
+Institution
+ Fei, Quanming. Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
+ Fei, Quanming. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
+ Fei, Quanming. Xiangya School of Medicine, Central South University, Changsha, China.
+ Tan, Yun. Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
+ Tan, Yun. School of Life Sciences, Central South University, Changsha, Hunan, China.
+ Tan, Yun. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
+ Yi, Minhan. Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
+ Yi, Minhan. School of Life Sciences, Central South University, Changsha, Hunan, China.
+ Yi, Minhan. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
+ Zhao, Wangcheng. Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
+ Zhao, Wangcheng. Xiangya School of Medicine, Central South University, Changsha, China.
+ Zhang, Yuan. Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. zhangyuan9194@csu.edu.cn.
+ Zhang, Yuan. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. zhangyuan9194@csu.edu.cn.
+MeSH Subject Headings
+ Male
+ Female
+ Humans
+ C-Reactive Protein/an [Analysis]
+ Tumor Necrosis Factor-alpha
+ Interleukin-6
+ Biomarkers
+ Metabolic Syndrome/co [Complications]
+ *Metabolic Syndrome
+ Inflammation/co [Complications]
+ Obesity/co [Complications]
+ *Sleep Apnea, Obstructive
+ *Heart Diseases
+ Phenotype
+Keyword Heading
+ CRP
+ Cardiometabolic phenotypes
+ IL-6
+ Obstructive sleep apnea
+ TNF-alpha
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Obstructive sleep apnea (OSA) shows a chronic inflammatory state which is often accompanied by cardiometabolic phenotypes. The aim of this study was to investigate whether or not there were differences of inflammatory proteins levels in patients with OSA with and without a certain phenotype so as to explore the associations between inflammation and additional OSA phenotypes.
+
+ METHODS: The literature was systematically screened and available data were collected on levels of tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and several interleukins (ILs) in patients with OSA with and without a certain phenotype. Overall effect size of standard mean difference (SMD) was used to compare the expression of differences between the two groups. Data analysis was conducted by Review Manager 5.3, and the threshold of p value was set as < 0.05.
+
+ RESULTS: A total of 31 articles were included, covering five traits of obesity, hypertension (HBP), metabolic syndrome (MS), heart disease, and sex. There were elevated levels of TNF-alpha (SMD = 0.63, p = 0.03), CRP (SMD = 0.64, p = 0.0001), and IL-6 (SMD = 0.83, p = 0.008) levels in OSA with obesity. Also, OSA with HBP showed significant increases of TNF-alpha (SMD = 0.36, p = 0.02), CRP (SMD = 0.98, p = 0.01), and IL-6 (SMD = 0.76, p < 0.0001) levels. A higher CRP level was also observed in OSA with MS (SMD = 0.31, p = 0.004) and female sex (SMD = 0.21, p = 0.002). There were no statistical differences for IL-1beta (p = 0.22) and CRP (p = 0.14) levels of OSA with obesity and heart disease respectively compared with OSA without corresponding phenotype. TNF-alpha (p = 0.66) and IL-6 (p = 0.49) levels also lacked statistically significant differences between female and male patients with OSA.
+
+ CONCLUSIONS: Our results revealed that inflammatory proteins TNF-alpha, CRP, and IL-6 levels were higher in obese and hypertensive patients with OSA and CRP levels were higher in OSA with metabolic syndrome, highlighting a link between inflammation and cardiometabolic complications in patients with OSA. Copyright © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 0 (Tumor Necrosis Factor-alpha). 0 (Interleukin-6). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1007%2fs11325-022-02697-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fei&issn=1520-9512&title=Sleep+%26+Breathing&atitle=Associations+between+cardiometabolic+phenotypes+and+levels+of+TNF-alpha%2C+CRP%2C+and+interleukins+in+obstructive+sleep+apnea.&volume=27&issue=3&spage=1033&epage=1042&date=2023&doi=10.1007%2Fs11325-022-02697-w&pmid=35982289&sid=OVID:medline
+
+<346>
+Unique Identifier
+ 35798678
+Title
+ Physical Activity, Inflammation, and Physical Function in Older Adults: Results From the Health & Retirement Study.
+Source
+ Biological Research for Nursing. 25(1):24-32, 2023 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hlebichuk JL; Gretebeck RJ; Garnier-Villarreal M; Piacentine LB; Singh M; Gretebeck KA
+Author NameID
+ Hlebichuk, Jeanne L; ORCID: https://orcid.org/0000-0001-8332-7188
+Authors Full Name
+ Hlebichuk, Jeanne L; Gretebeck, Randall J; Garnier-Villarreal, Mauricio; Piacentine, Linda B; Singh, Maharaj; Gretebeck, Kimberlee A.
+Institution
+ Hlebichuk, Jeanne L. College of Nursing, 5505Marquette University, Milwaukee, WI, USA.
+ Gretebeck, Randall J. College of Nursing, 5505Marquette University, Milwaukee, WI, USA.
+ Garnier-Villarreal, Mauricio. Faculty of Social Sciences, Sociology, 1190Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
+ Piacentine, Linda B. College of Nursing, 5505Marquette University, Milwaukee, WI, USA.
+ Singh, Maharaj. College of Nursing, 5505Marquette University, Milwaukee, WI, USA.
+ Gretebeck, Kimberlee A. College of Nursing, 5505Marquette University, Milwaukee, WI, USA.
+MeSH Subject Headings
+ Humans
+ Aged
+ Cross-Sectional Studies
+ *Exercise
+ *Inflammation
+ Adiposity
+ Aging
+ Obesity/co [Complications]
+ Biomarkers
+Keyword Heading
+ body mass index
+ exercise
+ functioning
+ inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Physical function declines with aging due to physical and biological changes. The biological process of aging has been associated with increases in systemic inflammation and a greater risk for chronic conditions. In older adults, physical activity aids in maintenance of function. However, the influence of inflammatory biomarkers and adiposity on physical activity and physical function needs to be further explored.
+
+ METHODS: A cross-sectional secondary data analysis from Wave 13 of the Health & Retirement Study (HRS) core biennial data and Venous Blood Study (VBS) was conducted. Structural equation modeling was used to establish the model and test the relationships.
+
+ RESULTS: Chronic low-level inflammation was moderately negatively correlated with physical activity (r = -0.326) and function (r = -0.367). Latent regressions showed that higher physical activity is associated with better physical function (unstandardized estimate = 0.600, p < .001) while inflammation negatively affects physical function (unstandardized estimate = -0.139, p < .001), and adiposity was not a predictor in the model (p = 0.055).
+
+ CONCLUSION: For older adults, preserving physical function by participation in physical activity and decreasing chronic inflammation are key preventive health strategies for older adults to maintain independence, with a need to further explore pro and anti-inflammatory biomarkers.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1177%2f10998004221111217
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hlebichuk&issn=1099-8004&title=Biological+Research+for+Nursing&atitle=Physical+Activity%2C+Inflammation%2C+and+Physical+Function+in+Older+Adults%3A+Results+From+the+Health+%26+Retirement+Study.&volume=25&issue=1&spage=24&epage=32&date=2023&doi=10.1177%2F10998004221111217&pmid=35798678&sid=OVID:medline
+
+<347>
+Unique Identifier
+ 35640116
+Title
+ Improved outcomes in rheumatoid arthritis with obesity after a weight loss intervention: randomized trial.
+Source
+ Rheumatology. 62(2):565-574, 2023 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ranganath VK; La Cava A; Vangala S; Brook J; Kermani TA; Furst DE; Taylor M; Kaeley GS; Carpenter C; Elashoff DA; Li Z
+Author NameID
+ Ranganath, Veena K; ORCID: https://orcid.org/0000-0003-3417-9478
+ Kermani, Tanaz A; ORCID: https://orcid.org/0000-0002-7335-7321
+ Furst, Daniel E; ORCID: https://orcid.org/0000-0001-7857-2373
+ Kaeley, Gurjit S; ORCID: https://orcid.org/0000-0003-1335-3131
+Authors Full Name
+ Ranganath, Veena K; La Cava, Antonio; Vangala, Sitaram; Brook, Jenny; Kermani, Tanaz A; Furst, Daniel E; Taylor, Mihaela; Kaeley, Gurjit S; Carpenter, Catherine; Elashoff, David A; Li, Zhaoping.
+Institution
+ Ranganath, Veena K. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ La Cava, Antonio. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ Vangala, Sitaram. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ Brook, Jenny. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ Kermani, Tanaz A. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ Furst, Daniel E. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ Furst, Daniel E. Department of Medicine, University of Washington, Seattle, WA, USA.
+ Furst, Daniel E. Department of Medicine, University of Florence, Florence, Italy.
+ Taylor, Mihaela. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ Kaeley, Gurjit S. Department of Medicine, University of Florida College of Medicine, Jacksonville, FL, USA.
+ Carpenter, Catherine. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ Elashoff, David A. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+ Li, Zhaoping. Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
+MeSH Subject Headings
+ Humans
+ Leptin
+ Antirheumatic Agents/tu [Therapeutic Use]
+ *Antirheumatic Agents
+ Adiponectin
+ Diet, Reducing
+ Single-Blind Method
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Arthritis, Rheumatoid/co [Complications]
+ Arthritis, Rheumatoid/dg [Diagnostic Imaging]
+ Arthritis, Rheumatoid/th [Therapy]
+ *Arthritis, Rheumatoid
+ Synovitis/dt [Drug Therapy]
+ *Synovitis
+ Biomarkers
+ Severity of Illness Index
+Keyword Heading
+ RA
+ clinical trial
+ obesity
+ outcome measures
+ ultrasound
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To examine whether a weight loss intervention programme improves RA disease activity and/or musculoskeletal ultrasound synovitis measures in obese RA patients.
+
+ METHODS: We conducted a proof-of-concept, 12-week, single-blind, randomized controlled trial of obese RA patients (BMI >= 30) with 28-joint DAS (DAS28) >= 3.2 and with evidence of power Doppler synovitis. Forty patients were randomized to the diet intervention (n = 20) or control group (n = 20). Diet intervention consisted of a hypocaloric diet of 1000-1500 kcal/day and high protein meal replacements. Co-primary outcomes included change in DAS28 and power Doppler ultrasound (PDUS)-34. Clinical disease activity, imaging, biomarkers, adipokines and patient-reported outcomes were monitored throughout the trial. Recruitment terminated early. All analyses were based on intent-to-treat for a significance level of 0.05.
+
+ RESULTS: The diet intervention group lost an average 9.5 kg/patient, while the control group lost 0.5 kg (P < 0.001). Routine Assessment of Patient Index Data 3 (RAPID3) improved, serum leptin decreased and serum adiponectin increased significantly within the diet group and between the groups (all P < 0.03). DAS28 decreased, 5.2 to 4.2, within the diet group (P < 0.001; -0.51 [95% CI -1.01, 0.00], P = 0.056, between groups). HAQ-Disability Index (HAQ-DI) improved significantly within the diet group (P < 0.04; P = 0.065 between group). Ultrasound measures and the multi-biomarker disease activity score did not differ between groups (PDUS-34 -2.0 [95% CI -7.00, 3.1], P = 0.46 between groups).
+
+ CONCLUSION: Obese RA patients on the diet intervention achieved weight loss. There were significant between group improvements for RAPID3, adiponectin and leptin levels, and positive trends for DAS28 and HAQ-DI. Longer-term, larger weight loss studies are needed to validate these findings, and will allow for further investigative work to improve the clinical management of obese RA patients.
+
+ TRIAL REGISTRATION: ClinicalTrials.gov, https://clinicaltrials.gov, NCT02881307. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Leptin). 0 (Antirheumatic Agents). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1093%2frheumatology%2fkeac307
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ranganath&issn=1462-0324&title=Rheumatology&atitle=Improved+outcomes+in+rheumatoid+arthritis+with+obesity+after+a+weight+loss+intervention%3A+randomized+trial.&volume=62&issue=2&spage=565&epage=574&date=2023&doi=10.1093%2Frheumatology%2Fkeac307&pmid=35640116&sid=OVID:medline
+
+<348>
+Unique Identifier
+ 35512760
+Title
+ Evaluation of Liver Metabolism Biomarkers in Metabolic Associated Fatty Liver Disease According to Obesity Phenotype.
+Source
+ Journal of the American Nutrition Association. 42(2):140-147, 2023 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Loureiro LM; Cordeiro A; Barboza L; Mendes R; Pereira S; Saboya CJ; Ramalho A
+Authors Full Name
+ Loureiro, Ligiane M; Cordeiro, Adryana; Barboza, Leticia; Mendes, Rodrigo; Pereira, Silvia; Saboya, Carlos J; Ramalho, Andrea.
+Institution
+ Loureiro, Ligiane M. Postgraduate Program, Doctorate in Nutritional Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
+ Loureiro, Ligiane M. Health Sciences Institute, Faculty of Nutrition, Federal University of Para (UFPA), Belem, Brazil.
+ Loureiro, Ligiane M. Center for Research on Micronutrients (NPqM), Institute of Nutrition Josue de Castro of UFRJ, Rio de Janeiro, Brazil.
+ Cordeiro, Adryana. Center for Research on Micronutrients (NPqM), Institute of Nutrition Josue de Castro of UFRJ, Rio de Janeiro, Brazil.
+ Cordeiro, Adryana. Biomedicine Department, Biochemistry Unit, Faculty of Medicine, University of Porto, Porto, Portugal.
+ Barboza, Leticia. Center for Research on Micronutrients (NPqM), Institute of Nutrition Josue de Castro of UFRJ, Rio de Janeiro, Brazil.
+ Mendes, Rodrigo. Postgraduate Program, Master in Applied Mathematics, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil.
+ Pereira, Silvia. Center for Research on Micronutrients (NPqM), Institute of Nutrition Josue de Castro of UFRJ, Rio de Janeiro, Brazil.
+ Pereira, Silvia. Multidisciplinary Center for Bariatric and Metabolic Surgery, Rio de Janeiro, Brazil.
+ Saboya, Carlos J. Center for Research on Micronutrients (NPqM), Institute of Nutrition Josue de Castro of UFRJ, Rio de Janeiro, Brazil.
+ Saboya, Carlos J. Multidisciplinary Center for Bariatric and Metabolic Surgery, Rio de Janeiro, Brazil.
+ Ramalho, Andrea. Department of Social and Applied Nutrition of the Institute of Nutrition, UFRJ, Rio de Janeiro, Brazil.
+MeSH Subject Headings
+ Humans
+ Cross-Sectional Studies
+ Obesity/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Biomarkers
+ Phenotype
+ *Obesity, Metabolically Benign
+Keyword Heading
+ MAFLD
+ Obesity
+ alkaline phosphatase
+ liver biomarkers
+ obesity phenotype
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To analyze the relationship between the biochemical markers of liver metabolism in different stages of Metabolic Associated Fatty Liver Disease (MAFLD) according to the obesity phenotype.
+
+ METHODOLOGY: This is a cross-sectional study with individuals with class III obesity classified according to the obesity phenotypes proposed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Biochemical and anthropometric variables were analyzed according to the staging of MAFLD and obesity phenotype.
+
+ RESULTS: A total of 50 subjects with MAFLD, 62% (n = 31) with steatosis and 38% (n = 19) with steatohepatitis without fibrosis; 36% were classified as metabolically healthy obesity (MHO) and 64% as metabolically unhealthy obesity (MUHO), respectively. Mean values of alkaline phosphatase were 85.44 +/- 27.27 vs. 61.92 +/- 17.57 (p = 0.006); gamma-glutamyl transpeptidase, 25.77 +/- 15.36 vs. 30.63 +/- 19.49 (p = 0.025); and albumin, 3.99 +/- 0.34 vs. 4.24 +/- 0.23 (p = 0.037), were lower and statistically significant in the MHO group with steatosis. The results show when considering individuals with IR, only AP is a predictor of unhealthy phenotype (B-0.934, 0.848- 1.029, p = 0.031).
+
+ CONCLUSION: MHO individuals with steatosis present lower severe changes related to markers of liver damage and function and AP is considered the predictor of MUHO phenotype.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1080%2f07315724.2021.2007427
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Loureiro&issn=2769-7061&title=Journal+of+the+American+Nutrition+Association&atitle=Evaluation+of+Liver+Metabolism+Biomarkers+in+Metabolic+Associated+Fatty+Liver+Disease+According+to+Obesity+Phenotype.&volume=42&issue=2&spage=140&epage=147&date=2023&doi=10.1080%2F07315724.2021.2007427&pmid=35512760&sid=OVID:medline
+
+<349>
+Unique Identifier
+ 35260034
+Title
+ Obesity affects type 2 biomarker levels in asthma.
+Source
+ Journal of Asthma. 60(2):385-392, 2023 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sharma V; Ricketts HC; Steffensen F; Goodfellow A; Cowan DC
+Author NameID
+ Sharma, Varun; ORCID: https://orcid.org/0000-0003-0183-3090
+Authors Full Name
+ Sharma, Varun; Ricketts, Helen Clare; Steffensen, Femke; Goodfellow, Anna; Cowan, Douglas C.
+Institution
+ Sharma, Varun. College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
+ Ricketts, Helen Clare. College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
+ Steffensen, Femke. Glasgow Clinical Research Facility, Glasgow Royal Infirmary, Glasgow, UK.
+ Goodfellow, Anna. Glasgow Clinical Research Facility, Glasgow Royal Infirmary, Glasgow, UK.
+ Cowan, Douglas C. Respiratory Department, Glasgow Royal Infirmary, Glasgow, UK.
+MeSH Subject Headings
+ Humans
+ Asthma/dt [Drug Therapy]
+ *Asthma
+ Retrospective Studies
+ Nitric Oxide/an [Analysis]
+ Eosinophils
+ Obesity/co [Complications]
+ Adrenal Cortex Hormones/tu [Therapeutic Use]
+ Biomarkers/an [Analysis]
+ Breath Tests
+ Exhalation
+Keyword Heading
+ BMI
+ Endotyping
+ FeNO
+ eosinophils
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Type 2 (T2) inflammation offers a therapeutic target for biologics. Previous trials suggest obesity influences T2-biomarker levels in asthma, though have not accounted for key variables, e.g. inhaled (ICS)/oral corticosteroid (OCS) use. We hypothesized that body mass index (BMI) would affect T2-biomarker levels, after adjusting for covariates.
+
+ METHODS: A retrospective analysis of data from two recent local trials of 153 participants with asthma (102 difficult-to-treat, 51 mild). Measurements included BMI, fractional exhaled nitric oxide (FeNO) and eosinophils. Correlation and regression analysis were performed for each biomarker to describe their relationship with BMI. Data was analyzed overall, and by asthma severity, T2-status and BMI tertile.
+
+ RESULTS: Increasing BMI was associated with reduction in FeNO when stratified by BMI tertile (25 ppb lowest tertile, 18 ppb highest tertile; p = 0.014). Spearmans rank showed a negative correlation between BMI and FeNO in difficult-to-treat asthma (rho= -0.309, p = 0.002). Linear regression adjusting for sex, age, smoking, atopy, allergic/perennial rhinitis, ICS and OCS confirmed BMI as a predictor of FeNO overall (beta= -2.848, p = 0.019). Eosinophils were reduced in the highest BMI tertile versus lowest in difficult-to-treat asthma (0.2x109/L, 0.3x109/L respectively; p = 0.02).
+
+ CONCLUSIONS: Increasing BMI is associated with lower FeNO in asthma when adjusted for relevant covariates, including steroid use. There also appears to be an effect on eosinophil levels. Obesity, therefore, affects T2 biomarker levels with implications for disease endotyping and determination of eligibility for biologic therapy. Whether this is due to masking of underlying T2-high status or development of a truly T2-low endotype requires further research.
+Registry Number/Name of Substance
+ 31C4KY9ESH (Nitric Oxide). 0 (Adrenal Cortex Hormones). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1080%2f02770903.2022.2051548
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sharma&issn=0277-0903&title=Journal+of+Asthma&atitle=Obesity+affects+type+2+biomarker+levels+in+asthma.&volume=60&issue=2&spage=385&epage=392&date=2023&doi=10.1080%2F02770903.2022.2051548&pmid=35260034&sid=OVID:medline
+
+<350>
+Unique Identifier
+ 33843397
+Title
+ Chemerin levels in metabolic syndrome: a promising biomarker.
+Source
+ Archives of Physiology & Biochemistry. 129(5):1009-1011, 2023 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jialal I
+Authors Full Name
+ Jialal, Ishwarlal.
+Institution
+ Jialal, Ishwarlal. Veterans Affairs Medical Center, 10535 Hospital Way, Mather, CA, 95655, USA.
+MeSH Subject Headings
+ Humans
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome
+ Biomarkers
+ Obesity/me [Metabolism]
+ Chemokines
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Chemokines).
+Publication Type
+ Editorial.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1080%2f13813455.2021.1912103
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jialal&issn=1381-3455&title=Archives+of+Physiology+%26+Biochemistry&atitle=Chemerin+levels+in+metabolic+syndrome%3A+a+promising+biomarker.&volume=129&issue=5&spage=1009&epage=1011&date=2023&doi=10.1080%2F13813455.2021.1912103&pmid=33843397&sid=OVID:medline
+
+<351>
+Unique Identifier
+ 33593088
+Title
+ Inflammatory diets are associated with lower total iron binding capacity in sera of young adults.
+Source
+ International Journal for Vitamin & Nutrition Research. 93(1):9-17, 2023 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Doherty JL; Larvie DY; Shivappa N; Hebert JR; Armah SM
+Authors Full Name
+ Doherty, Jeanne L; Larvie, Doreen Y; Shivappa, Nitin; Hebert, James R; Armah, Seth M.
+Institution
+ Doherty, Jeanne L. Department of Nutrition, University of North Carolina at Greensboro, Greensboro, USA.
+ Larvie, Doreen Y. Department of Nutrition, University of North Carolina at Greensboro, Greensboro, USA.
+ Shivappa, Nitin. Cancer Prevention and Control Program and the Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, USA.
+ Shivappa, Nitin. Department of Nutrition, Connecting Health Innovations LLC, Columbia, USA.
+ Hebert, James R. Cancer Prevention and Control Program and the Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, USA.
+ Hebert, James R. Department of Nutrition, Connecting Health Innovations LLC, Columbia, USA.
+ Armah, Seth M. Department of Nutrition, University of North Carolina at Greensboro, Greensboro, USA.
+MeSH Subject Headings
+ Humans
+ Young Adult
+ *Diet
+ Iron/me [Metabolism]
+ *Iron
+ Obesity
+ C-Reactive Protein/an [Analysis]
+ C-Reactive Protein/me [Metabolism]
+ Transferrin/an [Analysis]
+ Transferrin/me [Metabolism]
+ Inflammation
+ Biomarkers
+ Body Mass Index
+Keyword Heading
+ C-reactive protein
+ Hepcidin
+ dietary inflammatory index
+ inflammation
+ iron status
+ total iron binding capacity
+ young adults
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Chronic, systemic inflammation, which is associated with obesity and numerous other diseases, impairs iron status by increasing hepcidin concentration. Inflammation also decreases the concentration of transferrin, the main iron transport protein and a negative acute phase protein, which is indirectly assessed by measuring total iron binding capacity (TIBC). However, the contribution of diet-induced inflammation has not been studied. Data from two studies, namely Diet and Inflammation and Selenium and Inflammation Studies (total n=98) were used to assess the associations among Dietary Inflammatory Index (DII R) scores derived from three-day dietary records, body mass index (BMI=weight[kg]/height[m]2), inflammatory and hematological markers among young adults with normal-weight, overweight or obesity. Subjects' diets were also categorized as less inflammatory diets (LID) and inflammatory diets (ID) using cluster analysis. Independent t-test and regression analyses were used to assess associations in the data. Intakes of iron, proteins, fat, fiber, and calories were higher in the LID group compared to the ID group (p<0.05). Demographic characteristics and concentrations of C-reactive protein (CRP) and iron status biomarkers did not differ significantly between the two groups (p>0.05). Higher DII score was associated with increasing CRP (beta+SE=0.23+0.07, p=0.002) and lower TIBC (beta+SE=-8.46+3.44, p=0.02), independent of BMI category. The LID diet was associated with higher TIBC (beta+SE=29.87+10.75, p=0.007) compared to the ID diet. In conclusion, inflammatory diets may impair iron status by reducing the iron binding capacity of transferrin.
+Registry Number/Name of Substance
+ E1UOL152H7 (Iron). 9007-41-4 (C-Reactive Protein). 0 (Transferrin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2023
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med23&DO=10.1024%2f0300-9831%2fa000697
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Doherty&issn=0300-9831&title=International+Journal+for+Vitamin+%26+Nutrition+Research&atitle=Inflammatory+diets+are+associated+with+lower+total+iron+binding+capacity+in+sera+of+young+adults.&volume=93&issue=1&spage=9&epage=17&date=2023&doi=10.1024%2F0300-9831%2Fa000697&pmid=33593088&sid=OVID:medline
+
+<352>
+Unique Identifier
+ 36281153
+Title
+ Comprehensive assessment of neurocognitive function, inflammation markers, and adiposity in treated HIV and control.
+Source
+ Medicine. 101(42):e31125, 2022 Oct 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mouchati C; El Kamari V; Sattar A; Yu J; McComsey GA
+Author NameID
+ Mouchati, Christian; ORCID: https://orcid.org/0000-0002-3958-4125
+ McComsey, Grace A; ORCID: https://orcid.org/0000-0003-2690-8888
+Authors Full Name
+ Mouchati, Christian; El Kamari, Vanessa; Sattar, Abdus; Yu, Jiao; McComsey, Grace A.
+Institution
+ Mouchati, Christian. Case Western Reserve University, School of Medicine, OH, USA.
+ Mouchati, Christian. University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
+ El Kamari, Vanessa. Case Western Reserve University, School of Medicine, OH, USA.
+ El Kamari, Vanessa. University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
+ Sattar, Abdus. Case Western Reserve University, School of Medicine, OH, USA.
+ Yu, Jiao. Case Western Reserve University, School of Medicine, OH, USA.
+ McComsey, Grace A. Case Western Reserve University, School of Medicine, OH, USA.
+ McComsey, Grace A. University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
+ McComsey, Grace A. Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
+ McComsey, Grace A. Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
+MeSH Subject Headings
+ Male
+ Humans
+ Adult
+ Female
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Adiposity
+ Cross-Sectional Studies
+ Heroin
+ HIV Infections/co [Complications]
+ HIV Infections/dt [Drug Therapy]
+ HIV Infections/px [Psychology]
+ *HIV Infections
+ Obesity/co [Complications]
+ Biomarkers/me [Metabolism]
+ Inflammation/co [Complications]
+ RNA/me [Metabolism]
+Abstract
+ To compare the neurocognitive scores between persons living with human immunodeficiency virus (PLWH) and persons without human immunodeficiency virus (HIV) and assess the relationship between neurocognition, HIV status and variables, inflammation, and body composition measures. Cross-sectional study involving 225 participants (126 PLWH on antiretroviral therapy [ART] and 99 persons without HIV). For the first time in HIV, we used Cognivue R, an food and drug administration (FDA)-approved computer-based test to assess cognitive function. The test was calibrated to individuals' unique cognitive ability and measured 6 cognitive domains and 2 performance parameters. Markers of inflammation, immune activation, insulin resistance, and body fat composition (using dual-energy X-ray absorptiometry scan) were collected. Classical t tests, chi-square tests, and spearman correlations were used to compare and explore relationships between variables. Inverse probability weighting adjusted average treatment effect models were performed to evaluate the differences between PLWH and persons without HIV, adjusting for age, race, sex, and heroin use. Overall, 64% were male, 46% were Black, with a mean age of 43 years. Among PLWH, 83% had an undetectable HIV-1 RNA level (<=20 copies/mL). Compared persons without HIV, PLWH performed poorer across 4 domains: visuospatial (P = .035), executive function (P = .029), naming/language (P = .027), and abstraction (P = .018). In addition, PLWH had a significantly longer processing speed time compared to controls (1686.0 ms vs 1606.0 ms [P = .007]). In PLWH, lower cognitive testing domain scores were associated with higher inflammatory markers (high sensitivity C-reactive protein [hsCRP]) and with higher total fat and visceral adipose tissue (P < .05). Neurocognitive impairment (NCI) in HIV is associated with inflammation and total and central adiposity. Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). 70D95007SX (Heroin). 0 (Biomarkers). 63231-63-0 (RNA).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1097%2fMD.0000000000031125
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mouchati&issn=0025-7974&title=Medicine&atitle=Comprehensive+assessment+of+neurocognitive+function%2C+inflammation+markers%2C+and+adiposity+in+treated+HIV+and+control.&volume=101&issue=42&spage=e31125&epage=&date=2022&doi=10.1097%2FMD.0000000000031125&pmid=36281153&sid=OVID:medline
+
+<353>
+Unique Identifier
+ 35568907
+Title
+ Integrative analysis of multi-omics data to detect the underlying molecular mechanisms for obesity in vivo in humans.
+Source
+ Human Genomics. 16(1):15, 2022 05 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang Q; Meng XH; Qiu C; Shen H; Zhao Q; Zhao LJ; Tian Q; Sun CQ; Deng HW
+Author NameID
+ Deng, Hong-Wen; ORCID: https://orcid.org/0000-0002-2177-406X
+Authors Full Name
+ Zhang, Qiang; Meng, Xiang-He; Qiu, Chuan; Shen, Hui; Zhao, Qi; Zhao, Lan-Juan; Tian, Qing; Sun, Chang-Qing; Deng, Hong-Wen.
+Institution
+ Zhang, Qiang. Department of Community Nursing, School of Nursing and Health, Zhengzhou University, High-Tech Development Zone of States, Zhengzhou, 450001, Henan, People's Republic of China.
+ Zhang, Qiang. Tulane Center for Biomedical Informatics and Genomics, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
+ Meng, Xiang-He. Tulane Center for Biomedical Informatics and Genomics, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
+ Meng, Xiang-He. Center for System Biology, Data Sciences, and Reproductive Health, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, People's Republic of China.
+ Qiu, Chuan. Tulane Center for Biomedical Informatics and Genomics, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
+ Shen, Hui. Tulane Center for Biomedical Informatics and Genomics, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
+ Zhao, Qi. Department of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
+ Zhao, Lan-Juan. Tulane Center for Biomedical Informatics and Genomics, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
+ Tian, Qing. Tulane Center for Biomedical Informatics and Genomics, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
+ Sun, Chang-Qing. Department of Community Nursing, School of Nursing and Health, Zhengzhou University, High-Tech Development Zone of States, Zhengzhou, 450001, Henan, People's Republic of China.
+ Sun, Chang-Qing. Department of Social Medicine and Health Management, College of Public Health, Zhengzhou University, High-Tech Development Zone of States, Zhengzhou, 450001, Henan, People's Republic of China.
+ Deng, Hong-Wen. Tulane Center for Biomedical Informatics and Genomics, School of Medicine, Tulane University, New Orleans, LA, 70112, USA. hdeng2@tulane.edu.
+MeSH Subject Headings
+ Biomarkers
+ Humans
+ Obesity/ge [Genetics]
+ *Obesity
+Keyword Heading
+ Epigenomic
+ Genomic
+ Metabolomic
+ Multi-omics integration
+ Transcriptomic
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a complex, multifactorial condition in which genetic play an important role. Most of the systematic studies currently focuses on individual omics aspect and provide insightful yet limited knowledge about the comprehensive and complex crosstalk between various omics levels.
+
+ SUBJECTS AND METHODS: Therefore, we performed a most comprehensive trans-omics study with various omics data from 104 subjects, to identify interactions/networks and particularly causal regulatory relationships within and especially those between omic molecules with the purpose to discover molecular genetic mechanisms underlying obesity etiology in vivo in humans.
+
+ RESULTS: By applying differentially analysis, we identified 8 differentially expressed hub genes (DEHGs), 14 differentially methylated regions (DMRs) and 12 differentially accumulated metabolites (DAMs) for obesity individually. By integrating those multi-omics biomarkers using Mendelian Randomization (MR) and network MR analyses, we identified 18 causal pathways with mediation effect. For the 20 biomarkers involved in those 18 pairs, 17 biomarkers were implicated in the pathophysiology of obesity or related diseases.
+
+ CONCLUSIONS: The integration of trans-omics and MR analyses may provide us a holistic understanding of the underlying functional mechanisms, molecular regulatory information flow and the interactive molecular systems among different omic molecules for obesity risk and other complex diseases/traits. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs40246-022-00388-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1473-9542&title=Human+Genomics&atitle=Integrative+analysis+of+multi-omics+data+to+detect+the+underlying+molecular+mechanisms+for+obesity+in+vivo+in+humans.&volume=16&issue=1&spage=15&epage=&date=2022&doi=10.1186%2Fs40246-022-00388-x&pmid=35568907&sid=OVID:medline
+
+<354>
+Unique Identifier
+ 35785479
+Title
+ Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome. [Review]
+Source
+ Obesity. 30(7):1323-1334, 2022 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karra P; Winn M; Pauleck S; Bulsiewicz-Jacobsen A; Peterson L; Coletta A; Doherty J; Ulrich CM; Summers SA; Gunter M; Hardikar S; Playdon MC
+Author NameID
+ Coletta, Adriana; ORCID: https://orcid.org/0000-0002-2503-2792
+ Playdon, Mary C; ORCID: https://orcid.org/0000-0001-6082-0447
+Authors Full Name
+ Karra, Prasoona; Winn, Maci; Pauleck, Svenja; Bulsiewicz-Jacobsen, Alicja; Peterson, Lacie; Coletta, Adriana; Doherty, Jennifer; Ulrich, Cornelia M; Summers, Scott A; Gunter, Marc; Hardikar, Sheetal; Playdon, Mary C.
+Institution
+ Karra, Prasoona. Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, Utah, USA.
+ Karra, Prasoona. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Winn, Maci. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Winn, Maci. Department of Population Health Sciences, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
+ Pauleck, Svenja. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Bulsiewicz-Jacobsen, Alicja. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Peterson, Lacie. Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, Utah, USA.
+ Peterson, Lacie. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Coletta, Adriana. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Coletta, Adriana. Department of Health and Kinesiology, University of Utah, Salt Lake City, Utah, USA.
+ Doherty, Jennifer. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Doherty, Jennifer. Department of Population Health Sciences, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
+ Ulrich, Cornelia M. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Ulrich, Cornelia M. Department of Population Health Sciences, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
+ Summers, Scott A. Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, Utah, USA.
+ Gunter, Marc. Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
+ Gunter, Marc. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
+ Hardikar, Sheetal. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+ Hardikar, Sheetal. Department of Population Health Sciences, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
+ Playdon, Mary C. Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, Utah, USA.
+ Playdon, Mary C. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Humans
+ Metabolic Syndrome/co [Complications]
+ *Metabolic Syndrome
+ Neoplasms/co [Complications]
+ Neoplasms/et [Etiology]
+ *Neoplasms
+ Obesity/me [Metabolism]
+ Risk Factors
+Abstract
+ OBJECTIVES: The metabolic dysfunction driven by obesity, including hyperglycemia and dyslipidemia, increases risk for developing at least 13 cancer types. The concept of "metabolic dysfunction" is often defined by meeting various combinations of criteria for metabolic syndrome. However, the lack of a unified definition of metabolic dysfunction makes it difficult to compare findings across studies. This review summarizes 129 studies that evaluated variable definitions of metabolic dysfunction in relation to obesity-related cancer risk and mortality after a cancer diagnosis. Strategies for metabolic dysfunction management are also discussed.
+
+ METHODS: A comprehensive search of relevant publications in MEDLINE (PubMed) and Google Scholar with review of references was conducted.
+
+ RESULTS: Metabolic dysfunction, defined as metabolic syndrome diagnosis or any number of metabolic syndrome criteria out of clinical range, inflammatory biomarkers, or markers of metabolic organ function, has been associated with risk for, and mortality from, colorectal, pancreatic, postmenopausal breast, and bladder cancers. Metabolic dysfunction associations with breast and colorectal cancer risk have been observed independently of BMI, with increased risk in individuals with metabolically unhealthy normal weight or overweight/obesity compared with metabolically healthy normal weight.
+
+ CONCLUSION: Metabolic dysfunction is a key risk factor for obesity-related cancer, regardless of obesity status. Nonetheless, a harmonized definition of metabolic dysfunction will further clarify the magnitude of the relationship across cancer types, enable better comparisons across studies, and further guide criteria for obesity-related cancer risk stratification. Copyright © 2022 The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1002%2foby.23444
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karra&issn=1930-7381&title=Obesity&atitle=Metabolic+dysfunction+and+obesity-related+cancer%3A+Beyond+obesity+and+metabolic+syndrome.&volume=30&issue=7&spage=1323&epage=1334&date=2022&doi=10.1002%2Foby.23444&pmid=35785479&sid=OVID:medline
+
+<355>
+Unique Identifier
+ 35640889
+Title
+ Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants.
+Source
+ European heart journal cardiovascular Imaging. 23(11):1471-1481, 2022 10 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ardissino M; McCracken C; Bard A; Antoniades C; Neubauer S; Harvey NC; Petersen SE; Raisi-Estabragh Z
+Author NameID
+ Ardissino, Maddalena; ORCID: https://orcid.org/0000-0002-2654-8117
+ Neubauer, Stefan; ORCID: https://orcid.org/0000-0001-9017-5645
+ Raisi-Estabragh, Zahra; ORCID: https://orcid.org/0000-0002-7757-5465
+Authors Full Name
+ Ardissino, Maddalena; McCracken, Celeste; Bard, Andrew; Antoniades, Charalambos; Neubauer, Stefan; Harvey, Nicholas C; Petersen, Steffen E; Raisi-Estabragh, Zahra.
+Institution
+ Ardissino, Maddalena. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
+ McCracken, Celeste. William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
+ McCracken, Celeste. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DUUK.
+ Bard, Andrew. William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
+ Antoniades, Charalambos. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DUUK.
+ Antoniades, Charalambos. Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford OX1 2JD, UK.
+ Neubauer, Stefan. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DUUK.
+ Harvey, Nicholas C. MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, UK.
+ Harvey, Nicholas C. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YDUK.
+ Petersen, Steffen E. William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
+ Petersen, Steffen E. Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield EC1A 7BE, UK.
+ Petersen, Steffen E. Health Data Research UK, London, UK.
+ Petersen, Steffen E. Alan Turing Institute, London, UK.
+ Raisi-Estabragh, Zahra. William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
+ Raisi-Estabragh, Zahra. Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield EC1A 7BE, UK.
+MeSH Subject Headings
+ Humans
+ *Adiposity
+ Biological Specimen Banks
+ Pericardium/dg [Diagnostic Imaging]
+ Obesity/co [Complications]
+ Magnetic Resonance Imaging
+ Biomarkers
+ Phenotype
+ Hypertension/co [Complications]
+ *Hypertension
+ Inflammation
+ United Kingdom
+ Cholesterol
+ Lipids
+Keyword Heading
+ arterial stiffness
+ cardiometabolic disease
+ cardiovascular magnetic resonance
+ left atrium
+ left ventricle
+ pericardial fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: We evaluated independent associations of cardiovascular magnetic resonance (CMR)-measured pericardial adipose tissue (PAT) with cardiovascular structure and function and considered underlying mechanism in 42 598 UK Biobank participants.
+
+ METHODS AND RESULTS: We extracted PAT and selected CMR metrics using automated pipelines. We estimated associations of PAT with each CMR metric using linear regression adjusting for age, sex, ethnicity, deprivation, smoking, exercise, processed food intake, body mass index, diabetes, hypertension, height cholesterol, waist-to-hip ratio, impedance fat measures, and magnetic resonance imaging abdominal visceral adiposity measures. Higher PAT was independently associated with unhealthy left ventricular (LV) structure (greater wall thickness, higher LV mass, more concentric pattern of LV hypertrophy), poorer LV function (lower LV global function index, lower LV stroke volume), lower left atrial ejection fraction, and lower aortic distensibility. We used multiple mediation analysis to examine the potential mediating effect of cardiometabolic diseases and blood biomarkers (lipid profile, glycaemic control, inflammation) in the PAT-CMR relationships. Higher PAT was associated with cardiometabolic disease (hypertension, diabetes, high cholesterol), adverse serum lipids, poorer glycaemic control, and greater systemic inflammation. We identified potential mediation pathways via hypertension, adverse lipids, and inflammation markers, which overall only partially explained the PAT-CMR relationships.
+
+ CONCLUSION: We demonstrate association of PAT with unhealthy cardiovascular structure and function, independent of baseline comorbidities, vascular risk factors, inflammatory markers, and multiple non-invasive and imaging measures of obesity. Our findings support an independent role of PAT in adversely impacting cardiovascular health and highlight CMR-measured PAT as a potential novel imaging biomarker of cardiovascular risk. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 97C5T2UQ7J (Cholesterol). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1093%2fehjci%2fjeac101
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ardissino&issn=2047-2404&title=European+heart+journal+cardiovascular+Imaging&atitle=Pericardial+adiposity+is+independently+linked+to+adverse+cardiovascular+phenotypes%3A+a+CMR+study+of+42+598+UK+Biobank+participants.&volume=23&issue=11&spage=1471&epage=1481&date=2022&doi=10.1093%2Fehjci%2Fjeac101&pmid=35640889&sid=OVID:medline
+
+<356>
+Unique Identifier
+ 35681200
+Title
+ Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium.
+Source
+ Cardiovascular Diabetology. 21(1):99, 2022 06 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sujana C; Salomaa V; Kee F; Seissler J; Jousilahti P; Neville C; Then C; Koenig W; Kuulasmaa K; Reinikainen J; Blankenberg S; Zeller T; Herder C; Mansmann U; Peters A; Thorand B
+Author NameID
+ Sujana, Chaterina; ORCID: https://orcid.org/0000-0002-0663-2557
+ Salomaa, Veikko; ORCID: https://orcid.org/0000-0001-7563-5324
+ Koenig, Wolfgang; ORCID: https://orcid.org/0000-0002-2064-9603
+ Kuulasmaa, Kari; ORCID: https://orcid.org/0000-0003-2165-1411
+ Reinikainen, Jaakko; ORCID: https://orcid.org/0000-0002-7825-5359
+ Herder, Christian; ORCID: https://orcid.org/0000-0002-2050-093X
+ Mansmann, Ulrich; ORCID: https://orcid.org/0000-0002-9955-8906
+ Peters, Annette; ORCID: https://orcid.org/0000-0001-6645-0985
+ Thorand, Barbara; ORCID: https://orcid.org/0000-0002-8416-6440
+Corporate Author
+ BiomarCaRE Consortium
+Authors Full Name
+ Sujana, Chaterina; Salomaa, Veikko; Kee, Frank; Seissler, Jochen; Jousilahti, Pekka; Neville, Charlotte; Then, Cornelia; Koenig, Wolfgang; Kuulasmaa, Kari; Reinikainen, Jaakko; Blankenberg, Stefan; Zeller, Tanja; Herder, Christian; Mansmann, Ulrich; Peters, Annette; Thorand, Barbara.
+Institution
+ Sujana, Chaterina. Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764, Neuherberg, Germany.
+ Sujana, Chaterina. Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
+ Sujana, Chaterina. German Center for Diabetes Research (DZD), Partner Munchen-Neuherberg, Neuherberg, Germany.
+ Salomaa, Veikko. Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
+ Kee, Frank. Centre for Public Health, Queens University of Belfast, Belfast, Northern Ireland, UK.
+ Seissler, Jochen. Diabetes Zentrum, Medizinische Klinik Und Poliklinik IV, Klinikum Der Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
+ Jousilahti, Pekka. Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
+ Neville, Charlotte. Centre for Public Health, Queens University of Belfast, Belfast, Northern Ireland, UK.
+ Then, Cornelia. Diabetes Zentrum, Medizinische Klinik Und Poliklinik IV, Klinikum Der Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
+ Koenig, Wolfgang. Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
+ Koenig, Wolfgang. Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Munich, Germany.
+ Koenig, Wolfgang. German Centre for Cardiovascular Research (DZHK E.V.), Partner Site Munich Heart Alliance, Munich, Germany.
+ Kuulasmaa, Kari. Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
+ Reinikainen, Jaakko. Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
+ Blankenberg, Stefan. Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
+ Blankenberg, Stefan. German Centre for Cardiovascular Research (DZHK E.V.), Partner site Hamburg, Lubeck, Kiel, Hamburg, Germany.
+ Zeller, Tanja. Department for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
+ Zeller, Tanja. German Centre for Cardiovascular Research (DZHK E.V.), Partner site Hamburg, Lubeck, Kiel, Hamburg, Germany.
+ Herder, Christian. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
+ Herder, Christian. Division of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
+ Herder, Christian. German Center for Diabetes Research (DZD), Partner Dusseldorf, Neuherberg, Germany.
+ Mansmann, Ulrich. Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
+ Peters, Annette. Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764, Neuherberg, Germany.
+ Peters, Annette. German Center for Diabetes Research (DZD), Partner Munchen-Neuherberg, Neuherberg, Germany.
+ Peters, Annette. German Centre for Cardiovascular Research (DZHK E.V.), Partner Site Munich Heart Alliance, Munich, Germany.
+ Thorand, Barbara. Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764, Neuherberg, Germany. thorand@helmholtz-muenchen.de.
+ Thorand, Barbara. German Center for Diabetes Research (DZD), Partner Munchen-Neuherberg, Neuherberg, Germany. thorand@helmholtz-muenchen.de.
+MeSH Subject Headings
+ Adrenomedullin
+ Biomarkers
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ *Endothelin-1
+ Heart Disease Risk Factors
+ Humans
+ Obesity
+ Peptide Fragments
+ Prospective Studies
+ Protein Precursors
+Keyword Heading
+ Adrenomedullin
+ C-terminal-proendothelin-1
+ Cohort study
+ Endothelin-1
+ Epidemiology
+ Incident type 2 diabetes
+ Mendelian randomisation
+ Mid-regional-proadrenomedullin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Endothelin-1 (ET-1) and adrenomedullin (ADM) are commonly known as vasoactive peptides that regulate vascular homeostasis. Less recognised is the fact that both peptides could affect glucose metabolism. Here, we investigated whether ET-1 and ADM, measured as C-terminal-proET-1 (CT-proET-1) and mid-regional-proADM (MR-proADM), respectively, were associated with incident type 2 diabetes.
+
+ METHODS: Based on the population-based Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium data, we performed a prospective cohort study to examine associations of CT-proET-1 and MR-proADM with incident type 2 diabetes in 12,006 participants. During a median follow-up time of 13.8 years, 862 participants developed type 2 diabetes. The associations were examined in Cox proportional hazard models. Additionally, we performed two-sample Mendelian randomisation analyses using published data.
+
+ RESULTS: CT-proET-1 and MR-proADM were positively associated with incident type 2 diabetes. The multivariable hazard ratios (HRs) [95% confidence intervals (CI)] were 1.10 [1.03; 1.18], P = 0.008 per 1-SD increase of CT-proET-1 and 1.11 [1.02; 1.21], P = 0.016 per 1-SD increase of log MR-proADM, respectively. We observed a stronger association of MR-proADM with incident type 2 diabetes in obese than in non-obese individuals (P-interaction with BMI < 0.001). The HRs [95%CIs] were 1.19 [1.05; 1.34], P = 0.005 and 1.02 [0.90; 1.15], P = 0.741 in obese and non-obese individuals, respectively. Our Mendelian randomisation analyses yielded a significant association of CT-proET-1, but not of MR-proADM with type 2 diabetes risk.
+
+ CONCLUSIONS: Higher concentrations of CT-proET-1 and MR-proADM are associated with incident type 2 diabetes, but our Mendelian randomisation analysis suggests a probable causal link for CT-proET-1 only. The association of MR-proADM seems to be modified by body composition. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C-terminal proendothelin-1). 0 (Endothelin-1). 0 (Peptide Fragments). 0 (Protein Precursors). 0 (proendothelin 1). 148498-78-6 (Adrenomedullin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12933-022-01513-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sujana&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Associations+of+the+vasoactive+peptides+CT-proET-1+and+MR-proADM+with+incident+type+2+diabetes%3A+results+from+the+BiomarCaRE+Consortium.&volume=21&issue=1&spage=99&epage=&date=2022&doi=10.1186%2Fs12933-022-01513-9&pmid=35681200&sid=OVID:medline
+
+<357>
+Unique Identifier
+ 36150365
+Title
+ The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study.
+Source
+ Journal of Diabetes & its Complications. 36(11):108259, 2022 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Levitsky LL; Drews KL; Haymond M; Glubitosi-Klug RA; Levitt Katz LE; Mititelu M; Tamborlane W; Tryggestad JB; Weinstock RS
+Corporate Author
+ TODAY Study Group
+Authors Full Name
+ Levitsky, Lynne L; Drews, Kimberly L; Haymond, Morey; Glubitosi-Klug, Rose A; Levitt Katz, Lorraine E; Mititelu, Mihai; Tamborlane, William; Tryggestad, Jeanie B; Weinstock, Ruth S.
+Institution
+ Levitsky, Lynne L. Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States of America.
+ Drews, Kimberly L. George Washington University Biostatistics Center, 6110 Executive Blvd., Rockville, MD 20852, United States of America. Electronic address: kdrews@bsc.gwu.edu.
+ Haymond, Morey. Baylor College of Medicine, 6701 Fannin St, Houston, TX 77030, United States of America.
+ Glubitosi-Klug, Rose A. Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine, 1100 Euclid Ave, Cleveland, OH 44106, United States of America.
+ Levitt Katz, Lorraine E. Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19107, United States of America.
+ Mititelu, Mihai. University of Wisconsin, Department of Ophthalmology and Visual Sciences, 2870 University Avenue, Suite 206, Madison, WI 53705, United States of America.
+ Tamborlane, William. Yale University, 1 Long Wharf Drive, New Haven, CT 06511, United States of America.
+ Tryggestad, Jeanie B. Univeristy of Oklahoma Health Sciences Center, 1200 Children's Ave, Oklahoma, OK 73104, United States of America.
+ Weinstock, Ruth S. SUNY Upstate Medical University, 3229 E Genesee St, Syracuse, NY 13214, United States of America.
+MeSH Subject Headings
+ Adolescent
+ Humans
+ Biomarkers
+ Cholesterol, LDL
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Diabetic Retinopathy/ep [Epidemiology]
+ Diabetic Retinopathy/et [Etiology]
+ *Diabetic Retinopathy
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+Keyword Heading
+ Biomarkers
+ Obesity
+ Obesity paradox
+ Retinopathy
+ Type 2 diabetes
+ Youth
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To understand the relationship of obesity and 27 circulating inflammatory biomarkers to the prevalence of non-proliferative diabetic retinopathy (NPDR) in youth with type 2 diabetes.
+
+ METHODS: Youth with type 2 diabetes who participated in the TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) study were followed for 2-6.5 years. Digital fundus photographs were obtained in the last year of the study. Blood samples during the study were processed for inflammatory biomarkers, and these were correlated with obesity tertiles and presence of retinopathy.
+
+ RESULTS: Higher BMI was associated with an increase in circulating levels of metabolic biomarkers including high sensitivity C-reactive protein (hsCRP), plasminogen activator inhibitor 1 (PAI-1), fibrinogen, LDL-cholesterol (LDL-C) and Apolipoprotein B (ApoB), tumor necrosis factor receptors 1 and 2 (TNFR-1 and -2), interleukin 6 (IL-6), E-selectin, and homocysteine, as well as a decrease in the metabolic risk markers HDL-cholesterol (HDLC), and insulin-like growth factor binding protein 1 (IGFBP-1). Although NPDR risk decreased with increasing obesity, it was not associated with any of the measured biomarkers.
+
+ CONCLUSIONS: Circulating levels of measured biomarkers did not elucidate the "obesity paradox" of decreased NPDR in the most obese participants in the TODAY study.
+
+ TRIAL REGISTRATION: clinicaltrials.govNCT00081328. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL).
+Publication Type
+ Clinical Study. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.jdiacomp.2022.108259
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Levitsky&issn=1056-8727&title=Journal+of+Diabetes+%26+its+Complications&atitle=The+obesity+paradox%3A+Retinopathy%2C+obesity%2C+and+circulating+risk+markers+in+youth+with+type+2+diabetes+in+the+TODAY+Study.&volume=36&issue=11&spage=108259&epage=&date=2022&doi=10.1016%2Fj.jdiacomp.2022.108259&pmid=36150365&sid=OVID:medline
+
+<358>
+Unique Identifier
+ 36146902
+Title
+ Exercise improves testicular morphology and oxidative stress parameters in rats with testicular damage induced by a high-fat diet.
+Source
+ Andrologia. 54(11):e14600, 2022 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elmas MA; Ozakpinar OB; Kolgazi M; Sener G; Arbak S; Ercan F
+Author NameID
+ Arbak, Serap; ORCID: https://orcid.org/0000-0001-6279-9602
+ Ercan, Feriha; ORCID: https://orcid.org/0000-0003-2339-5669
+Authors Full Name
+ Elmas, Merve Acikel; Ozakpinar, Ozlem Bingol; Kolgazi, Meltem; Sener, Goksel; Arbak, Serap; Ercan, Feriha.
+Institution
+ Elmas, Merve Acikel. Department of Histology and Embryology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
+ Ozakpinar, Ozlem Bingol. Department of Biochemistry, Faculty of Pharmacy, Marmara University, Istanbul, Turkey.
+ Kolgazi, Meltem. Department of Physiology, Acibadem University School of Medicine, Istanbul, Turkey.
+ Sener, Goksel. Fenerbahce University, Vocational School of Health Service, Istanbul, Turkey.
+ Arbak, Serap. Department of Histology and Embryology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
+ Ercan, Feriha. Department of Histology and Embryology, Marmara University School of Medicine, Istanbul, Turkey.
+MeSH Subject Headings
+ Animals
+ Male
+ Rats
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Obesity/me [Metabolism]
+ Oxidative Stress/ph [Physiology]
+ *Oxidative Stress
+ Testis/me [Metabolism]
+ *Testis
+ Physical Conditioning, Animal/ph [Physiology]
+Keyword Heading
+ blood testis barrier
+ exercise
+ high-fat diet
+ oxidative stress
+ ultrastructure
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and male infertility are problems that affect population. Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood-testis barrier, and inflammatory and oxidative biomarkers in rats that became obese due to a high-fat diet (HFD). Male rats received a standard diet (STD group) or a HFD (HFD group) for 18 weeks. During the final 6 weeks of the experiment, swimming exercises (1 h/5 days/week) were given to half of these animals (STD + EXC and HFD + EXC groups). Finally, blood and testicular tissues were analysed by biochemical and histological methods. Body weight, leptin, malondialdehyde, interleukin-6, TNF-alpha and myeloperoxidase levels, apoptotic cells and DNA fragmentation were increased, and testis weight, insulin, FSH, LH, testosterone, glutathione and superoxide dysmutase levels, proliferative cells, ZO-1, occludin, and gap junction protein Cx43 immunoreactivity were decreased in the HFD group. All these hormonal, morphological, oxidative and inflammatory biomarkers were enhanced in the HFD + EXC group. It is thought that exercise protected testicular cytotoxicity by regulating hormonal and oxidant/antioxidant balances and testicular function, inhibiting inflammation and apoptosis, as well as preserving blood-testis barrier. Copyright © 2022 Wiley-VCH GmbH.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2fand.14600
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elmas&issn=0303-4569&title=Andrologia&atitle=Exercise+improves+testicular+morphology+and+oxidative+stress+parameters+in+rats+with+testicular+damage+induced+by+a+high-fat+diet.&volume=54&issue=11&spage=e14600&epage=&date=2022&doi=10.1111%2Fand.14600&pmid=36146902&sid=OVID:medline
+
+<359>
+Unique Identifier
+ 36778595
+Title
+ Novel nutraceutical supplements with yeast beta-glucan, prebiotics, minerals, and Silybum marianum (silymarin) ameliorate obesity-related metabolic and clinical parameters: A double-blind randomized trial.
+Source
+ Frontiers in Endocrinology. 13:1089938, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nehmi-Filho V; Santamarina AB; de Freitas JA; Trarbach EB; de Oliveira DR; Palace-Berl F; de Souza E; de Miranda DA; Escamilla-Garcia A; Otoch JP; Pessoa AFM
+Authors Full Name
+ Nehmi-Filho, Victor; Santamarina, Aline Boveto; de Freitas, Jessica Alves; Trarbach, Ericka Barbosa; de Oliveira, Daniela Rodrigues; Palace-Berl, Fanny; de Souza, Erica; de Miranda, Danielle Araujo; Escamilla-Garcia, Antonio; Otoch, Jose Pinhata; Pessoa, Ana Flavia Marcal.
+Institution
+ Nehmi-Filho, Victor. Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ Nehmi-Filho, Victor. Research and Development Efeom Nutrition S/A, Sao Paulo, SP, Brazil.
+ Santamarina, Aline Boveto. Department of Biosciences, Federal University of Sao Paulo (UNIFESP), Santos, SP, Brazil.
+ de Freitas, Jessica Alves. Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ de Freitas, Jessica Alves. Research and Development Efeom Nutrition S/A, Sao Paulo, SP, Brazil.
+ Trarbach, Ericka Barbosa. Laboratory of Cellular and Molecular Endocrinology (LIM25), Division of Endocrinology and Metabology, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ de Oliveira, Daniela Rodrigues. Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ de Oliveira, Daniela Rodrigues. Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States.
+ Palace-Berl, Fanny. Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ de Souza, Erica. Monte Azul Ambulatory, Sao Paulo, SP, Brazil.
+ de Miranda, Danielle Araujo. Departament of Physiology, Escola Paulista de Medicina/Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
+ Escamilla-Garcia, Antonio. University Hospital of the University of Sao Paulo, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ Otoch, Jose Pinhata. Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ Otoch, Jose Pinhata. Research and Development Efeom Nutrition S/A, Sao Paulo, SP, Brazil.
+ Otoch, Jose Pinhata. University Hospital of the University of Sao Paulo, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ Pessoa, Ana Flavia Marcal. Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
+ Pessoa, Ana Flavia Marcal. Research and Development Efeom Nutrition S/A, Sao Paulo, SP, Brazil.
+ Pessoa, Ana Flavia Marcal. Natural Products Committee, Brazilian Academic Consortium for Integrative Health (CABSIN), Sao Paulo, Brazil.
+MeSH Subject Headings
+ Male
+ Adult
+ Humans
+ Female
+ Silymarin/tu [Therapeutic Use]
+ *Silymarin
+ Saccharomyces cerevisiae
+ Silybum marianum
+ Non-alcoholic Fatty Liver Disease/dt [Drug Therapy]
+ *Non-alcoholic Fatty Liver Disease
+ Prebiotics
+ Diabetes Mellitus, Type 2/th [Therapy]
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ beta-Glucans/tu [Therapeutic Use]
+ *beta-Glucans
+ Obesity/co [Complications]
+ Dietary Supplements
+ Minerals
+ Biomarkers
+Keyword Heading
+ Silybum marianum
+ endocrine parameters
+ nutraceutics
+ obesity
+ prebiotic
+ supplement
+ transaminases
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Purpose: It is known that obesity has a multifactorial etiology that involves genetic and environmental factors. The WHO estimates the worldwide prevalence of 1.9 billion overweight adults and more than 650 million people with obesity. These alarming data highlight the high and growing prevalence of obesity and represent a risk factor for the development and aggravation of other chronic diseases, such as nonalcoholic fatty liver disease (NAFLD) that is frequently considered the hepatic outcome of type 2 diabetes. The use of non-pharmacological therapies such as food supplements, nutraceuticals, and natural integrative therapies has grown as an alternative tool for obesity-related diseases compared to conventional medications. However, it is a still little explored research field and lacks scientific evidence of therapeutic effectiveness. Considering this, the aim is to evaluate whether a new nutraceutical supplement composition can improve and supply essential mineral nutrients, providing an improvement of obesity-related metabolic and endocrine parameters.
+
+ Methods: Sedentary volunteers (women and men) with body mass index (BMI) <=34.9 kg/m2 were divided into two groups: Novel Nutraceutical Supplement_(S) (n = 30) and Novel Nutraceutical Supplement (n = 29), differing in the absence (S) or presence of silymarin, respectively. Volunteers were instructed to take two capsules in the morning and two capsules in the evening. No nutritional intervention was performed during the study period. The data (anthropometrics and anamneses) and harvest blood (biochemistry and hormonal exams) were collected at three different time points: baseline time [day 0 (T0)], day 90 (T90), and day 180 (T180) post-supplementation.
+
+ Results: In the anthropometric analysis, the waist circumference in middle abdomen (WC-mid) and waist circumference in iliac crest (WC-IC) were reduced. Also, the waist-to-height ratio (WHt R) and waist-to-hip ratio (WHR) seem to slightly decrease alongside the supplementation period with both nutraceutical supplements tested as well as transaminase enzyme ratio [aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR)], a known as a biomarker of NAFLD, and endocrine hormones cortisol and thyroid-stimulating hormone (TSH) at 90 and 180 days post-supplementation.
+
+ Conclusions: In a condition associated with sedentary and no nutritional intervention, the new nutraceutical supplement composition demonstrated the ability to be a strong and newfangled tool to improve important biomarkers associated with obesity and its comorbidities. Copyright © 2023 Nehmi-Filho, Santamarina, de Freitas, Trarbach, de Oliveira, Palace-Berl, de Souza, de Miranda, Escamilla-Garcia, Otoch and Pessoa.
+Registry Number/Name of Substance
+ 0 (Silymarin). 0 (Prebiotics). 0 (beta-Glucans). 0 (Minerals). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.1089938
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nehmi-Filho&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Novel+nutraceutical+supplements+with+yeast+beta-glucan%2C+prebiotics%2C+minerals%2C+and+Silybum+marianum+%28silymarin%29+ameliorate+obesity-related+metabolic+and+clinical+parameters%3A+A+double-blind+randomized+trial.&volume=13&issue=&spage=1089938&epage=&date=2022&doi=10.3389%2Ffendo.2022.1089938&pmid=36778595&sid=OVID:medline
+
+<360>
+Unique Identifier
+ 30843767
+Title
+ Flaxseed supplementation improves anthropometric measurements, metabolic, and inflammatory biomarkers in overweight and obese adults.
+Source
+ International Journal for Vitamin & Nutrition Research. 92(3-4):161-168, 2022 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yari Z; Rahimlou M; Poustchi H; Hekmatdoost A
+Authors Full Name
+ Yari, Zahra; Rahimlou, Mehran; Poustchi, Hossein; Hekmatdoost, Azita.
+Institution
+ Yari, Zahra. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Science, Tehran, Iran.
+ Rahimlou, Mehran. Department of Nutrition, Faculty of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Poustchi, Hossein. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Hekmatdoost, Azita. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Science, Tehran, Iran.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Mass Index
+ Dietary Supplements
+ *Flax
+ Humans
+ *Insulin Resistance
+ Obesity/me [Metabolism]
+ Overweight/me [Metabolism]
+ Triglycerides
+Keyword Heading
+ Flaxseed
+ inflammatory biomarkers
+ insulin resistance
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: The aim of this study was to assess the effects of supplementation with flaxseed on anthropometric measurements, lipid profile, insulin resistance, and inflammatory biomarkers in overweight and obese adults. Methods: Fifty overweight and obese adults with body mass index (BMI) of 30.72 +/- 3.31 kg/m2 participated in this study. Participants were randomly assigned to take lifestyle advice or lifestyle advice plus 30 g/day milled flaxseed for 12 weeks. The primary outcome was body weight; secondary outcomes included other anthropometric parameters, lipid profile and inflammatory biomarkers. Results: At the end of the study, the following significant mean differences were seen in flaxseed and control groups, respectively: weight [-9.36 vs. -3.09 kg; P < 0.001], BMI [-3.34 vs. -1.2 kg/m2; P < 0.001], triglycerides [-62.88 vs. -9.85 mg/dL; P < 0.001], total cholesterol [-32.2 vs. -14.95 mg/dL; P = 0.04], homeostatic model assessment (HOMA-IR) [1.25 vs. -0.32; P = 0.024], high sensitive- C reactive protein [-2.2 vs. -1.01 mmol/L; P < 0.001] and tumor necrosis factor-alpha [-1.34 vs. -0.14 pg/mL; P = 0.005]. Conclusion: These results suggest that flaxseed supplementation in addition to lifestyle modification is significantly superior to lifestyle modification alone for weight loss. More studies with different dosages of flaxseed are needed to find the optimal dosage. This trial was registered at clinicaltrials.gov as NCT02410668.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1024%2f0300-9831%2fa000565
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yari&issn=0300-9831&title=International+Journal+for+Vitamin+%26+Nutrition+Research&atitle=Flaxseed+supplementation+improves+anthropometric+measurements%2C+metabolic%2C+and+inflammatory+biomarkers+in+overweight+and+obese+adults.&volume=92&issue=3-4&spage=161&epage=168&date=2022&doi=10.1024%2F0300-9831%2Fa000565&pmid=30843767&sid=OVID:medline
+
+<361>
+Unique Identifier
+ 36967169
+Title
+ Different Isocaloric Meals and Adiposity Modify Energy Expenditure and Clinical and Metabolomic Biomarkers During Resting and Exercise States in a Randomized Crossover Acute Trial of Normal-Weight and Overweight/Obese Men.
+Source
+ Journal of Nutrition. 152(4):1118-1129, 2022 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xiong Q; Sun L; Luo Y; Yun H; Shen X; Yin H; Chen X; Lin X
+Authors Full Name
+ Xiong, Quan; Sun, Liang; Luo, Yaogan; Yun, Huan; Shen, Xia; Yin, Huiyong; Chen, Xiafei; Lin, Xu.
+Institution
+ Xiong, Quan. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Sun, Liang. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. Electronic address: sunliang@sibs.ac.cn.
+ Luo, Yaogan. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Yun, Huan. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Shen, Xia. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.
+ Yin, Huiyong. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, Shanghai Tech University, Shanghai, China; Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China.
+ Chen, Xiafei. Huadong Hospital Affiliated with Fudan University, Shanghai, China.
+ Lin, Xu. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, China. Electronic address: xlin@sibs.ac.cn.
+MeSH Subject Headings
+ Male
+ Humans
+ Overweight/me [Metabolism]
+ *Overweight
+ *Adiposity
+ Obesity/me [Metabolism]
+ Energy Metabolism
+ Glucose
+ Proteins/me [Metabolism]
+ Biomarkers
+ Meals
+ Postprandial Period/ph [Physiology]
+ Cross-Over Studies
+ Blood Glucose/me [Metabolism]
+Keyword Heading
+ amino acids
+ energy expenditure
+ fat oxidation
+ macronutrients
+ untargeted metabolomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Few studies have assessed the integrative effects of diet, BMI, and exercise on postprandial changes in energy and circulating metabolic profiles.
+
+ OBJECTIVES: We aimed to assess the collective effects of 3 isocaloric meals high in carbohydrate (74.2% energy), fat (64.6% energy), or protein (39.5% energy) on energy expenditure and clinical and metabolomic biomarkers under resting and exercise conditions in normal-weight and overweight/obese men.
+
+ METHODS: This crossover controlled acute trial included 20 normal-weight (BMI, 18.5 to <24 kg/m2) and 20 overweight/obese (BMI >=24 kg/m2) men aged 18-45 years. Each of 3 test meals was provided for 2 continuous days: a resting day without exercise, followed by an exercise day with a bicycling exercise of 50% maximal oxygen consumption (postprandial 90-120 minutes). Energy expenditure (exploratory outcome of primary interest) was measured using indirect calorimetry. Fasting and postprandial 2-hour serum clinical and metabolomic biomarkers (secondary interest) were measured. Mixed models were used to examine the effects of meal, time, and/or BMI category.
+
+ RESULTS: On the resting day, no significant between-meal differences were detected for energy expenditure. However, high-carbohydrate and high-fat meals induced the highest postprandial 2-hour increase in glucose (0.34 +/- 0.15 mmol/L) and triglyceride (0.95 +/- 0.09 mmol/L), respectively, while the high-protein meal reduced glucose (-0.48 +/- 0.08 mmol/L) and total cholesterol (-0.01 +/- 0.03 mmol/L; all Pmeal values < 0.001). On the exercise day, a high-carbohydrate meal significantly promoted the carbohydrate oxidation rate but suppressed the fat oxidation rate (Pmeal < 0.05), while its postprandial glucose response was attenuated by bicycling (-0.31 +/- 0.03 mmol/L; Pexercise < 0.001). We identified 69 metabolites as key features in discriminating between the 3 meals, and overweight/obese men had more varieties of metabolites than normal-weight men.
+
+ CONCLUSIONS: Three isocaloric meals induced unique postprandial changes in clinical and metabolomic biomarkers, while exercise prevented the hyperglycemia induced by a high-carbohydrate meal. Overweight/obese men were more responsive to the meal challenges than normal-weight men. This trial was registered at clinicaltrials.gov as NCT03231618. Copyright © 2022 American Society for Nutrition.
+Registry Number/Name of Substance
+ IY9XDZ35W2 (Glucose). 0 (Proteins). 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Randomized Controlled Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1093%2fjn%2fnxac006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xiong&issn=0022-3166&title=Journal+of+Nutrition&atitle=Different+Isocaloric+Meals+and+Adiposity+Modify+Energy+Expenditure+and+Clinical+and+Metabolomic+Biomarkers+During+Resting+and+Exercise+States+in+a+Randomized+Crossover+Acute+Trial+of+Normal-Weight+and+Overweight%2FObese+Men.&volume=152&issue=4&spage=1118&epage=1129&date=2022&doi=10.1093%2Fjn%2Fnxac006&pmid=36967169&sid=OVID:medline
+
+<362>
+Unique Identifier
+ 36696243
+Title
+ Soluble receptor for advanced glycation end products (sRAGE) correlates with obesity-related parameters, and it is not easy to be modified by moderate caloric restriction in obese humans.
+Source
+ Journal of Physiology & Pharmacology. 73(4), 2022 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kanikowska D; Kanikowska A; Swora-Cwynar E; Grzymislawski M; Sato M; Breborowicz A; Witowski J; Korybalska K
+Authors Full Name
+ Kanikowska, D; Kanikowska, A; Swora-Cwynar, E; Grzymislawski, M; Sato, M; Breborowicz, A; Witowski, J; Korybalska, K.
+Institution
+ Kanikowska, D. Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland. dkanikowska@ump.edu.pl.
+ Kanikowska, A. Department of Internal Diseases, Metabolism and Nutrition, Poznan University of Medical Science, Poznan, Poland.
+ Swora-Cwynar, E. Department of Internal Diseases, Metabolism and Nutrition, Poznan University of Medical Science, Poznan, Poland.
+ Grzymislawski, M. Department of Internal Diseases, Metabolism and Nutrition, Poznan University of Medical Science, Poznan, Poland.
+ Sato, M. Institutional Research, Aichi Medical University School of Medicine, Aichi, Japan.
+ Breborowicz, A. Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
+ Witowski, J. Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
+ Korybalska, K. Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
+MeSH Subject Headings
+ Humans
+ Receptor for Advanced Glycation End Products
+ *Caloric Restriction
+ Body Mass Index
+ *Obesity
+ Body Weight
+ Glycation End Products, Advanced
+ Biomarkers
+Abstract
+ Deficiency of a soluble form of the advanced glycation end products receptor (sRAGE) is implicated in obesity-induced complications. Serum sRAGE is inclined to be modified by changes in body weight. We analysed serum sRAGE concentrations in patients with obesity undergoing moderate calorie restriction, which mimics the real-life situation and is not harmful to obese humans. Serum sRAGE was measured by immunoassay in 50 patients with obesity who underwent calorie restriction by 300-500 kcal/day for 8 weeks. In effect calorie restriction resulted in an expected decrease in body weight (by 2.1 kg for an 8-week intervention, p<0.0001), as well as reduced systolic blood pressure, modified dyslipidemia (cholesterol, triglycerides), reduced obesity-related inflammation (tumor necrosis factor-alfa, interleukin-6, C-reactive protein), improved insulin sensitivity. However, it was not accompanied by any significant change in sRAGE concentration. There was a strong negative correlation between BMI and the sRAGE level. Accordingly, the levels of sRAGE were the highest in lean control. In conclusion: a modest weight reduction is unlikely to improve decreased sRAGE levels.
+Registry Number/Name of Substance
+ 0 (Receptor for Advanced Glycation End Products). 0 (Glycation End Products, Advanced). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.26402%2fjpp.2022.4.06
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kanikowska&issn=0867-5910&title=Journal+of+Physiology+%26+Pharmacology&atitle=Soluble+receptor+for+advanced+glycation+end+products+%28sRAGE%29+correlates+with+obesity-related+parameters%2C+and+it+is+not+easy+to+be+modified+by+moderate+caloric+restriction+in+obese+humans.&volume=73&issue=4&spage=&epage=&date=2022&doi=10.26402%2Fjpp.2022.4.06&pmid=36696243&sid=OVID:medline
+
+<363>
+Unique Identifier
+ 36564806
+Title
+ Higher daytime systolic BP, prepregnancy BMI and an elevated sFlt-1/PlGF ratio predict the development of hypertension in normotensive pregnant women.
+Source
+ Reproductive Biology & Endocrinology. 20(1):175, 2022 Dec 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lara-Barea A; Sanchez-Lechuga B; Aguilar-Diosdado M; Lopez-Tinoco C
+Authors Full Name
+ Lara-Barea, Almudena; Sanchez-Lechuga, Begona; Aguilar-Diosdado, Manuel; Lopez-Tinoco, Cristina.
+Institution
+ Lara-Barea, Almudena. Department of Endocrinology and Nutrition, Puerta del Mar Hospital, 11009, Cadiz, Spain. almlarbar@gmail.com.
+ Lara-Barea, Almudena. Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar Hospital, 11009, Cadiz, Spain. almlarbar@gmail.com.
+ Sanchez-Lechuga, Begona. Department of Endocrinology and Nutrition, Puerta del Mar Hospital, 11009, Cadiz, Spain.
+ Aguilar-Diosdado, Manuel. Department of Endocrinology and Nutrition, Puerta del Mar Hospital, 11009, Cadiz, Spain.
+ Aguilar-Diosdado, Manuel. Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar Hospital, 11009, Cadiz, Spain.
+ Aguilar-Diosdado, Manuel. Department of Medicine, Cadiz University (UCA), 11003, Cadiz, Spain.
+ Lopez-Tinoco, Cristina. Department of Endocrinology and Nutrition, Puerta del Mar Hospital, 11009, Cadiz, Spain.
+ Lopez-Tinoco, Cristina. Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar Hospital, 11009, Cadiz, Spain.
+ Lopez-Tinoco, Cristina. Department of Medicine, Cadiz University (UCA), 11003, Cadiz, Spain.
+MeSH Subject Headings
+ Female
+ Pregnancy
+ Humans
+ Male
+ Blood Pressure
+ Pregnant Women
+ Body Mass Index
+ Blood Pressure Monitoring, Ambulatory
+ Placenta Growth Factor
+ *Hypertension
+ Biomarkers
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Vascular Endothelial Growth Factor Receptor-1
+ *Pre-Eclampsia
+Keyword Heading
+ Ambulatory blood pressure monitoring
+ Cytokine profile; sFlt-1/PIGF ratio
+ Hypertensive disorders of pregnancy
+ Predictor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The risk of hypertensive disorders of pregnancy (HDP) varies in women with gestational diabetes mellitus (GDM), depending on the degree of insulin resistance and is also influenced by obesity. The aim of this study was to evaluate clinical features, blood pressure (BP) profiles and inflammatory markers, to identify patients with an elevated risk of developing HDP.
+
+ METHODS: A total of 146 normotensive pregnant women were studied. We analysed the relationships of BP profiles detected by ambulatory blood pressure monitoring (ABPM) with serum biomarkers and angiogenic factors and their association with the development of HDP.
+
+ RESULTS: Fourteen (9.6%) women developed HDP, of which 11 had GDM and 8 had obesity. Women with HDP had higher values of 24-h and daytime systolic/diastolic BP (113/69 vs. 104/64; 115/72 vs. 106/66 mmHg, respectively; p < 0.05). Higher levels of leptin (10.97 +/- 0.82 vs. 10.2 +/- 1.11; p = 0.018) andmonocyte chemoattractant protein-1 (MCP-1) (5.24 +/- 0.60 vs. 4.9 +/- 0.55; p = 0.044) and a higher soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PlGF) ratio (4.37 +/- 2.2 vs. 2.2 +/- 1.43; p = 0.003) were also observed in the HDP patients. Multivariate analysis showed that a higher sFlt-1/PlGF ratio was associated with an increased risk of developing HDP [OR = 2.02; IC 95%: 1.35-3.05]. Furthermore, higher daytime systolic BP [OR = 1.27; IC 95% 1.00-1.26] and prepregnancy body mass index (BMI) [OR = 1.14; IC 95%: 1.01-1.30] significantly increased the risk of developing HDP.
+
+ CONCLUSIONS: Higher daytime systolic BP values, prepregnancy BMI and the sFlt-1/PlGF ratio are useful for identifying normotensive pregnant women with an increased risk of developing HDP. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 144589-93-5 (Placenta Growth Factor). 0 (Biomarkers). EC 2-7-10-1 (Vascular Endothelial Growth Factor Receptor-1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12958-022-01050-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lara-Barea&issn=1477-7827&title=Reproductive+Biology+%26+Endocrinology&atitle=Higher+daytime+systolic+BP%2C+prepregnancy+BMI+and+an+elevated+sFlt-1%2FPlGF+ratio+predict+the+development+of+hypertension+in+normotensive+pregnant+women.&volume=20&issue=1&spage=175&epage=&date=2022&doi=10.1186%2Fs12958-022-01050-w&pmid=36564806&sid=OVID:medline
+
+<364>
+Unique Identifier
+ 36564775
+Title
+ Insulin resistance mediates obesity-related risk of cardiovascular disease: a prospective cohort study.
+Source
+ Cardiovascular Diabetology. 21(1):289, 2022 12 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tian X; Chen S; Wang P; Xu Q; Zhang Y; Luo Y; Wu S; Wang A
+Authors Full Name
+ Tian, Xue; Chen, Shuohua; Wang, Penglian; Xu, Qin; Zhang, Yijun; Luo, Yanxia; Wu, Shouling; Wang, Anxin.
+Institution
+ Tian, Xue. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Tian, Xue. Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Tian, Xue. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
+ Tian, Xue. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
+ Chen, Shuohua. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, 57 Xinhua East Road, Tangshan, 063000, China.
+ Wang, Penglian. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Wang, Penglian. Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Xu, Qin. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Xu, Qin. Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Xu, Qin. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
+ Zhang, Yijun. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Zhang, Yijun. Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Zhang, Yijun. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
+ Zhang, Yijun. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
+ Luo, Yanxia. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
+ Luo, Yanxia. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
+ Wu, Shouling. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, 57 Xinhua East Road, Tangshan, 063000, China. drwusl@163.com.
+ Wang, Anxin. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. wanganxin@bjtth.org.
+ Wang, Anxin. Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. wanganxin@bjtth.org.
+ Wang, Anxin. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China. wanganxin@bjtth.org.
+MeSH Subject Headings
+ Humans
+ *Insulin Resistance
+ Overweight
+ Obesity, Abdominal/di [Diagnosis]
+ Obesity, Abdominal/ep [Epidemiology]
+ Prospective Studies
+ Blood Glucose
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Glucose
+ Triglycerides
+ Risk Factors
+ Biomarkers
+Keyword Heading
+ Cardiovascular disease
+ Central obesity
+ General obesity
+ Insulin resistance
+ Mediation analysis
+ The triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The mechanisms linking obesity to cardiovascular disease (CVD) are still not clearly defined. Individuals who are overweight or obese often develop insulin resistance, mediation of the association between obesity and CVD through the insulin resistance seems plausible and has not been investigated. This study aimed to evaluate whether and to what extend the effect of general and central obesity on cardiovascular disease (CVD) is mediated by insulin resistance.
+
+ METHODS: A total of 94,136 participants without CVD at baseline were recruited from the Kailuan study. Insulin resistance was evaluated by the triglyceride-glucose (TyG) index, calculating as ln [fasting triglyceride (mg/dL) x fasting glucose (mg/dL)/2]. Mediation analysis using a new 2-stage regression method for survival data proposed by Valeri and VanderWeele was to explore the mediating effects of the TyG index on the association between obesity and CVD.
+
+ RESULTS: During a median follow-up of 13.01 years, we identified 7327 cases of CVD. Mediation analyses showed that 47.81% of the total association (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.12-1.24) between overweight and CVD was mediated through the TyG index (HR [indirect association], 1.07; 95% CI, 1.07-1.09), and the proportion mediated was 37.94% for general obesity. For central obesity, analysis by waist circumference, waist/hip, and waist/height categories yielded an attenuated proportion mediated of 32.01, 35.02, and 31.06% for obesity, taken normal weight as reference.
+
+ CONCLUSIONS: The association between obesity and CVD was mediated by TyG index, suggesting proper control of insulin resistance can be effective to reduce the effects of obesity on CVD. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Blood Glucose). IY9XDZ35W2 (Glucose). 0 (Triglycerides). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12933-022-01729-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tian&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Insulin+resistance+mediates+obesity-related+risk+of+cardiovascular+disease%3A+a+prospective+cohort+study.&volume=21&issue=1&spage=289&epage=&date=2022&doi=10.1186%2Fs12933-022-01729-9&pmid=36564775&sid=OVID:medline
+
+<365>
+Unique Identifier
+ 36564713
+Title
+ Machine learning framework for gut microbiome biomarkers discovery and modulation analysis in large-scale obese population.
+Source
+ BMC Genomics. 23(1):850, 2022 Dec 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu Y; Zhu J; Wang H; Lu W; Lee YK; Zhao J; Zhang H
+Authors Full Name
+ Liu, Yaoliang; Zhu, Jinlin; Wang, Hongchao; Lu, Wenwei; Lee, Yuan Kun; Zhao, Jianxin; Zhang, Hao.
+Institution
+ Liu, Yaoliang. State Key Laboratory of Food Science and Technology, Jiangnan University, P. R, Wuxi, 214122, Jiangsu, China.
+ Liu, Yaoliang. School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
+ Zhu, Jinlin. State Key Laboratory of Food Science and Technology, Jiangnan University, P. R, Wuxi, 214122, Jiangsu, China. wx_zjl@jiangnan.edu.cn.
+ Zhu, Jinlin. School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China. wx_zjl@jiangnan.edu.cn.
+ Wang, Hongchao. State Key Laboratory of Food Science and Technology, Jiangnan University, P. R, Wuxi, 214122, Jiangsu, China.
+ Wang, Hongchao. School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
+ Lu, Wenwei. State Key Laboratory of Food Science and Technology, Jiangnan University, P. R, Wuxi, 214122, Jiangsu, China.
+ Lu, Wenwei. School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
+ Lee, Yuan Kun. Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 21 Lower Kent Ridge Rd, Singapore, Singapore.
+ Lee, Yuan Kun. International Joint Research Laboratory for Pharmabiotics & Antibiotic Resistance, Jiangnan University, Wuxi, China.
+ Zhao, Jianxin. State Key Laboratory of Food Science and Technology, Jiangnan University, P. R, Wuxi, 214122, Jiangsu, China.
+ Zhao, Jianxin. School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
+ Zhang, Hao. State Key Laboratory of Food Science and Technology, Jiangnan University, P. R, Wuxi, 214122, Jiangsu, China.
+ Zhang, Hao. School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
+ Zhang, Hao. National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, 214122, Jiangsu, China.
+ Zhang, Hao. Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi, 214122, Jiangsu, China.
+MeSH Subject Headings
+ Humans
+ *Gastrointestinal Microbiome
+ Obesity
+ Feces/mi [Microbiology]
+ Biomarkers
+ Machine Learning
+Keyword Heading
+ Counterfactual explanation
+ Ensemble learning
+ Geography
+ Gut microbiome
+ Machine learning
+ Obesity
+ Reinforcement learning
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The gut microbiome has proven to be an important factor affecting obesity; however, it remains a challenge to identify consistent biomarkers across geographic locations and perform precisely targeted modulation for obese individuals.
+
+ RESULTS: This study proposed a systematic machine learning framework and applied it to 870 human stool metagenomes across five countries to obtain comprehensive regional shared biomarkers and conduct a personalized modulation analysis. In our pipeline, a heterogeneous ensemble feature selection diagram is first developed to determine an optimal subset of biomarkers through the aggregation of multiple techniques. Subsequently, a deep reinforcement learning method was established to alter the targeted composition to the desired healthy target. In this manner, we can realize personalized modulation by counterfactual inference. Consequently, a total of 42 species were identified as regional shared biomarkers, and they showed good performance in distinguishing obese people from the healthy group (area under curve (AUC) =0.85) when demonstrated on validation datasets. In addition, by pooling all counterfactual explanations, we found that Akkermansia muciniphila, Faecalibacterium prausnitzii, Prevotella copri, Bacteroides dorei, Bacteroides eggerthii, Alistipes finegoldii, Alistipes shahii, Eubacterium sp. _CAG_180, and Roseburia hominis may be potential broad-spectrum targets with consistent modulation in the multi-regional obese population.
+
+ CONCLUSIONS: This article shows that based on our proposed machine-learning framework, we can obtain more comprehensive and accurate biomarkers and provide modulation analysis for the obese population. Moreover, our machine-learning framework will also be very useful for other researchers to further obtain biomarkers and perform counterfactual modulation analysis in different diseases. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12864-022-09087-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=1471-2164&title=BMC+Genomics&atitle=Machine+learning+framework+for+gut+microbiome+biomarkers+discovery+and+modulation+analysis+in+large-scale+obese+population.&volume=23&issue=1&spage=850&epage=&date=2022&doi=10.1186%2Fs12864-022-09087-2&pmid=36564713&sid=OVID:medline
+
+<366>
+Unique Identifier
+ 36564342
+Title
+ Serum copeptin as a biomarker of hypertension in children with obesity.
+Source
+ Pediatrics International. 64(1):e15355, 2022 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gor Z; Bezen D; Turkmenoglu Y; Vurgun E; Irdem A; Dursun H
+Author NameID
+ Gor, Zeynep; ORCID: https://orcid.org/0000-0003-3759-3332
+ Bezen, Digdem; ORCID: https://orcid.org/0000-0003-3977-5527
+ Turkmenoglu, Yelda; ORCID: https://orcid.org/0000-0001-7472-8748
+ Vurgun, Eren; ORCID: https://orcid.org/0000-0002-2288-1123
+ Irdem, Ahmet; ORCID: https://orcid.org/0000-0002-2565-5674
+ Dursun, Hasan; ORCID: https://orcid.org/0000-0002-8817-494X
+Authors Full Name
+ Gor, Zeynep; Bezen, Digdem; Turkmenoglu, Yelda; Vurgun, Eren; Irdem, Ahmet; Dursun, Hasan.
+Institution
+ Gor, Zeynep. Department of Pediatrics, Health Science University, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
+ Bezen, Digdem. Department of Pediatric Endocrinology, Health Science University, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
+ Turkmenoglu, Yelda. Department of Pediatrics, Health Science University, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
+ Vurgun, Eren. Department of Biochemistry, Health Science University, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
+ Irdem, Ahmet. Department of Pediatric Cardiology, Health Science University, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
+ Dursun, Hasan. Department of Pediatric Nephrology, Health Science University, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.
+MeSH Subject Headings
+ Humans
+ Child
+ *Uric Acid
+ Hypertension/co [Complications]
+ Hypertension/di [Diagnosis]
+ *Hypertension
+ Obesity/co [Complications]
+ Biomarkers
+ Potassium
+ Sodium
+Keyword Heading
+ children
+ copeptin
+ hypertension
+ obesity
+ uric acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hypertension (HT) in obesity has been reported frequently in children in recent years. The role of copeptin and uric acid here are not well known. We aimed to investigate the relationship between HT and serum copeptin and uric acid levels in children with obesity.
+
+ METHODS: We included 80 children with obesity who were admitted to our hospital between April 2018 and September 2018. The patients were separated into two groups: hypertensive and non-hypertensive. Serum copeptin levels were measured using the enzyme-linked immunosorbent assay.
+
+ RESULTS: Copeptin levels were significantly higher in patients with HT than in those without (p = 0.0001). In addition, serum uric acid levels in patients with HT were significantly higher, while the serum potassium levels were significantly lower (p = 0.01) than in those without HT (p = 0.001). In correlation analyses, a positive correlation was detected between blood sodium and copeptin levels (p = 0.037).
+
+ CONCLUSIONS: Hypertensive children with obesity had higher serum copeptin and uric acid and lower blood potassium levels. Moreover, copeptin levels were positively correlated with blood sodium levels. Thus, in addition to copeptin, serum uric acid, potassium, and sodium levels may be important in the diagnosis and follow-up of children with HT. Copyright © 2022 Japan Pediatric Society.
+Registry Number/Name of Substance
+ 0 (copeptins). 268B43MJ25 (Uric Acid). 0 (Biomarkers). RWP5GA015D (Potassium). 9NEZ333N27 (Sodium).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2fped.15355
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gor&issn=1328-8067&title=Pediatrics+International&atitle=Serum+copeptin+as+a+biomarker+of+hypertension+in+children+with+obesity.&volume=64&issue=1&spage=e15355&epage=&date=2022&doi=10.1111%2Fped.15355&pmid=36564342&sid=OVID:medline
+
+<367>
+Unique Identifier
+ 36551255
+Title
+ The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men.
+Source
+ Biomolecules. 12(12), 2022 12 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cobeta P; Pariente R; Osorio A; Marchan M; Blazquez L; Pestana D; Galindo J; Botella-Carretero JI
+Author NameID
+ Pariente, Roberto; ORCID: https://orcid.org/0000-0001-9323-5236
+ Botella-Carretero, Jose I; ORCID: https://orcid.org/0000-0002-6425-2747
+Authors Full Name
+ Cobeta, Pilar; Pariente, Roberto; Osorio, Alvaro; Marchan, Marta; Blazquez, Luis; Pestana, David; Galindo, Julio; Botella-Carretero, Jose I.
+Institution
+ Cobeta, Pilar. Department of Anesthesiology, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Cobeta, Pilar. Instituto Ramon y Cajal de Investigacion Sanitaria-IRyCIS, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Pariente, Roberto. Department of Inmunology, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Osorio, Alvaro. Instituto Ramon y Cajal de Investigacion Sanitaria-IRyCIS, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Osorio, Alvaro. Department of Angiology and Vascular Surgery, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Marchan, Marta. Department of Endocrinology and Nutrition, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Blazquez, Luis. Instituto Ramon y Cajal de Investigacion Sanitaria-IRyCIS, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Blazquez, Luis. Department of General and Digestive Surgery, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Pestana, David. Department of Anesthesiology, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Galindo, Julio. Instituto Ramon y Cajal de Investigacion Sanitaria-IRyCIS, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Galindo, Julio. Department of General and Digestive Surgery, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Botella-Carretero, Jose I. Instituto Ramon y Cajal de Investigacion Sanitaria-IRyCIS, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+ Botella-Carretero, Jose I. Department of Endocrinology and Nutrition, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
+MeSH Subject Headings
+ Humans
+ Male
+ *Bariatric Surgery
+ Biomarkers/me [Metabolism]
+ *Carotid Intima-Media Thickness
+ Inflammation/dg [Diagnostic Imaging]
+ Inflammation/et [Etiology]
+ Obesity/su [Surgery]
+ Obesity/co [Complications]
+ *Obesity
+ Plasminogen Activator Inhibitor 1
+ Risk Factors
+ Testosterone/me [Metabolism]
+Keyword Heading
+ cardiovascular risk
+ carotid intima-media thickness
+ inflammation
+ metabolic surgery
+ testosterone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity increases cardiovascular risk in men through several mechanisms. Among them, low-grade chronic inflammation and obesity-associated hypogonadism have been described. We aimed to study the effects of metabolic surgery on the carotid-intima media thickness through changes in inflammatory, endothelial biomarkers, and testosterone. We included 60 men; 20 submitted to laparoscopic Roux-en-Y gastric bypass (RYGB), 20 to sleeve gastrectomy (SG), and 20 to lifestyle modification (controls). Several inflammatory and endothelial biomarkers and total testosterone (TT) were measured at baseline and six months after surgery. Free testosterone (FT) was calculated, and carotid intima-media thickness (cIMT) was measured by ultrasonography. Compared to controls, cIMT decreased after surgery concomitantly with CRP, PAI-1, sICAM-1, and IL-18 (p < 0.01) and with an increase in sTWEAK (p = 0.027), with no differences between RYGB and SG. The increase in TT and FT after surgery correlated with the changes in cIMT (p = 0.010 and p = 0.038, respectively), but this association disappeared after multivariate analysis. Linear regression showed that sTWEAK (s = -0.245, p = 0.039), PAI-1 (s = 0.346, p = 0.005), and CRP (s = 0.236, p = 0.049) were associated with the changes in cIMT (R2 = 0.267, F = 6.664, p = 0.001). In conclusion, both RYGB and SG induced improvements in inflammation and endothelial biomarkers that drove a decrease in cIMT compared to men with obesity who submitted to diet and exercise.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Plasminogen Activator Inhibitor 1). 3XMK78S47O (Testosterone).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fbiom12121827
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cobeta&issn=2218-273X&title=Biomolecules&atitle=The+Beneficial+Changes+on+Inflammatory+and+Endothelial+Biomarkers+Induced+by+Metabolic+Surgery+Decreases+the+Carotid+Intima-Media+Thickness+in+Men.&volume=12&issue=12&spage=&epage=&date=2022&doi=10.3390%2Fbiom12121827&pmid=36551255&sid=OVID:medline
+
+<368>
+Unique Identifier
+ 36537088
+Title
+ The effect of positive pressure ventilation on serum ischemia-modified albumin levels in obese patients with obstructive sleep apnea syndrome.
+Original Title
+ Obstruktif uyku apne sendromu tanisi alan obez hastalarda PAP tedavisinin serum iskemi modifiye albumin duzeyine etkisi.
+Source
+ Tuberkuloz ve Toraks. 70(4):313-323, 2022 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ajun EG; Ucar ZZ; Oktay Arslan B; Karakoyun I; Erbaycu AE; Isbilen Basok B
+Authors Full Name
+ Ajun, Ebru Gamze; Ucar, Zeynep Zeren; Oktay Arslan, Burcu; Karakoyun, Inanc; Erbaycu, Ahmet Emin; Isbilen Basok, Banu.
+Institution
+ Ajun, Ebru Gamze. Clinic of Chest Diseases, Health Sciences University Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkiye.
+ Ucar, Zeynep Zeren. Clinic of Chest Diseases, Health Sciences University Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkiye.
+ Oktay Arslan, Burcu. Clinic of Chest Diseases, Health Sciences University Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkiye.
+ Karakoyun, Inanc. Clinic of Biochemistry, Health Sciences University Tepecik Research and Training Hospital, Izmir, Turkiye.
+ Erbaycu, Ahmet Emin. Department of Chest Diseases, Izmir Bakircay University, Izmir, Turkiye.
+ Isbilen Basok, Banu. Clinic of Biochemistry, Health Sciences University Tepecik Research and Training Hospital, Izmir, Turkiye.
+MeSH Subject Headings
+ Humans
+ Male
+ Female
+ Biomarkers
+ Serum Albumin
+ Positive-Pressure Respiration
+ Sleep Apnea, Obstructive/di [Diagnosis]
+ *Sleep Apnea, Obstructive
+ Obesity/co [Complications]
+ *Insulins
+ Continuous Positive Airway Pressure
+Abstract
+ Introduction: Respiratory abnormalities in obstructive sleep apnea syndrome (OSAS) are corrected with positive pressure ventilation treatments. We investigated the effect of positive airway pressure (PAP) treatment on the serum level of ischemia-modified albumin (IMA), an oxidative stress product, in OSAS patients with higher body mass index (BMI) and indication for PAP treatment.
+
+ Materials and Methods: Seven consecutive female and 23 male patients with a BMI of >=30 kg/m2 who were diagnosed as having OSAS according to ICSD3 criteria and were planned for PAP, were included. The Epworth Sleepiness Scale and STOP-Bang Questionnaire were performed. Morning arterial blood gas, hemogram, biochemistry, insulin, and IMA were measured after polysomnography and after three months of PAP.
+
+ Result: There were no significant changes in lactate, CRP, and serum electrolyte levels measured before and after PAP, except for potassium. When 30 patients were compared in terms of serum IMA levels at baseline and after treatment, the mean baseline value was 0.56 absorbance units (ABSU), and the 3rd-month follow-up IMA value was 0.53 ABSU (p= 0.537). The mean serum fasting insulin level was 15.85 microIU/mL and 11.6 (p= 0.002) and the mean HOMA index was 4.4 and 3.0 (p= 0.001), respectively.
+
+ Conclusions: Serum IMA levels seem not to be an appropriate marker for the evaluation of PAP treatment in OSAS patients with higher BMI. PAP is associated with a decrease in the fasting insulin level, HOMA index, and hematocrit, but not with serum electrolytes except potassium.
+Registry Number/Name of Substance
+ 0 (ischemia-modified albumin). 0 (Biomarkers). 0 (Serum Albumin). 0 (Insulins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.5578%2ftt.20229602
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ajun&issn=0494-1373&title=Tuberkuloz+ve+Toraks&atitle=Obstruktif+uyku+apne+sendromu+tanisi+alan+obez+hastalarda+PAP+tedavisinin+serum+iskemi+modifiye+albumin+duzeyine+etkisi.&volume=70&issue=4&spage=313&epage=323&date=2022&doi=10.5578%2Ftt.20229602&pmid=36537088&sid=OVID:medline
+
+<369>
+Unique Identifier
+ 36524417
+Title
+ [Effect of prebiotics, probiotics, and symbiotics on molecular markers of inflammation in obesity.]. [Review] [Spanish]
+Original Title
+ Efecto de los prebioticos, probioticos y simbioticos sobre marcadores moleculares de inflamacion en la obesidad.
+Source
+ Revista Espanola de Salud Publica. 96, 2022 Dec 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rangel-Torres BE; Garcia-Montoya IA; Jimenez-Vega F; Rodriguez-Tadeo A
+Authors Full Name
+ Rangel-Torres, Brian Eduardo; Garcia-Montoya, Isui Abril; Jimenez-Vega, Florinda; Rodriguez-Tadeo, Alejandra.
+Institution
+ Rangel-Torres, Brian Eduardo. Departamento de Ciencias Quimico-Biologicas, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez. Ciudad Juarez. Mexico.
+ Garcia-Montoya, Isui Abril. Departamento de Ciencias Quimico-Biologicas, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez. Ciudad Juarez. Mexico.
+ Jimenez-Vega, Florinda. Departamento de Ciencias Quimico-Biologicas, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez. Ciudad Juarez. Mexico.
+ Rodriguez-Tadeo, Alejandra. Departamento de Ciencias de la Salud, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez. Ciudad Juarez. Mexico.
+MeSH Subject Headings
+ Humans
+ *Prebiotics
+ Spain
+ Probiotics/tu [Therapeutic Use]
+ Probiotics/pd [Pharmacology]
+ *Probiotics
+ Obesity/th [Therapy]
+ Inflammation
+ Biomarkers
+ Fatty Acids
+Keyword Heading
+ Inflammation
+ Obesity
+ Prebiotics
+ Probiotics
+ Spain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Obesity is an inflammatory disease that is widely distributed in the world's population and is related to the leading causes of death. The use of prebiotics and probiotics can be an alternative treatment against obesity. Although there have been found physiological and biochemical effects of its use, the molecular mechanism remains unclear. The present review analyzed articles that suggested the activation of pathways related to the metabolism of the fatty acids, as well as the impact on anti-inflammatory mechanisms, as part of the mechanism of action of prebiotics and probiotics, to know therefore the possible pathways activated by the prebiotics and probiotics.
+
+ METHODS: Exhaustive research was made on articles included in the period 2005-2021 related to the effect of prebiotics and probiotics in obesity, inflammatory diseases, and metabolic diseases. Identifying an effect on anti-inflammatory cytokines and PPAR modulation, with a consequent decrease in inflammation and fat degradation.
+
+ RESULTS: A total of sixty-three articles were obtained, which were classified as basic information on molecular markers of obesity, the effect of prebiotics and probiotics in obesity, and articles related to anti-inflammatory effects and fatty acid metabolism observed in obesity and other inflammatory diseases.
+
+ CONCLUSIONS: The effect of prebiotics and probiotics in obesity can be linked to the anti-inflammatory mechanism produced, and this effect leads to an increase in the expression of genes related to fatty acid metabolism.
+Other Abstract
+ Publisher
+ OBJETIVO: La obesidad es una enfermedad ampliamente distribuida en el mundo y resulta una de las principales causas de mortalidad. El uso de prebioticos y probioticos promete una alternativa en el tratamiento de la obesidad, a pesar de los efectos fisiologicos y bioquimicos encontrados, aunque no esta aun esclarecido el mecanismo molecular. Por lo que, en la presente revision, se analizaron articulos que sugerian la activacion de vias relacionadas al metabolismo de grasas y azucares, asi como el impacto en los mecanismos antinflamatorios, como parte del mecanismo de accion de los prebioticos y probioticos, con la finalidad de conocer las posibles vias de accion por las cuales se puede obtener el efecto observado.
+ METODOS: Fue realizada una busqueda exhaustiva de articulos comprendidos en el periodo 2005-2021 relacionados con el efecto de los prebioticos y probioticos en la obesidad y las enfermedades tanto inflamatorias como metabolicas.
+ RESULTADOS: Fueron obtenidos un total de sesenta y tres articulos, los cuales fueron clasificados en: informacion basica de marcadores moleculares de obesidad; efecto de prebioticos y probioticos en la obesidad; articulos de relacion efectos antinflamatorios y metabolismo de grasas observados en la obesidad y otras enfermedades inflamatorias. Se identifico un efecto sobre las citoquinas antinflamatorias y la modulacion de los PPAR, con consecuente disminucion de la inflamacion y degradacion de grasas.
+ CONCLUSIONES: El efecto de los prebioticos y probioticos en la obesidad se sugiere esta ligado al mecanismo antinflamatorio que producen, lo que a su vez conlleva a un aumento en la expresion de genes relacionados con el metabolismo de grasas.
+ Language: Spanish
+Registry Number/Name of Substance
+ 0 (Prebiotics). 0 (Biomarkers). 0 (Fatty Acids).
+Publication Type
+ English Abstract. Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&AN=36524417
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rangel-Torres&issn=1135-5727&title=Revista+Espanola+de+Salud+Publica&atitle=Efecto+de+los+prebioticos%2C+probioticos+y+simbioticos+sobre+marcadores+moleculares+de+inflamacion+en+la+obesidad.&volume=96&issue=&spage=&epage=&date=2022&doi=&pmid=36524417&sid=OVID:medline
+
+<370>
+Unique Identifier
+ 36466447
+Title
+ Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers.
+Source
+ Frontiers in Public Health. 10:962852, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Muntean C; Sasaran MO; Crisan A; Banescu C
+Authors Full Name
+ Muntean, Carmen; Sasaran, Maria Oana; Crisan, Adriana; Banescu, Claudia.
+Institution
+ Muntean, Carmen. Department of Paediatrics I, "George Emil Palade" University of Medicine, Pharmacy, Sciences, and Technology of Targu Mures, Targu Mures, Romania.
+ Sasaran, Maria Oana. Department of Paediatrics III, "George Emil Palade" University of Medicine, Pharmacy, Sciences, and Technology of Targu Mures, Targu Mures, Romania.
+ Crisan, Adriana. Center for Advanced Medical and Pharmaceutical Research, "George Emil Palade" University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures, Romania.
+ Banescu, Claudia. Center for Advanced Medical and Pharmaceutical Research, "George Emil Palade" University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures, Romania.
+MeSH Subject Headings
+ Adolescent
+ Child
+ Humans
+ Biomarkers
+ Cross-Sectional Studies
+ Obesity/ge [Genetics]
+ *Overweight
+ Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/ge [Genetics]
+ Polymorphism, Single Nucleotide
+ *PPAR gamma
+ Triglycerides
+Keyword Heading
+ PPARG
+ anthropometric parameters
+ child
+ metabolic parameters
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pediatric obesity presents a multifactorial etiology, which involves genetic traits as well, including single nucleotide polymorphisms. The aim of the study is to investigate the contribution of PPARG gene polymorphisms (namely Pro12Ala rs1801282, His447His rs3856806, and Pro115Gln rs1800571) and PPARGC1A rs8192678 SNP on the anthropometric and metabolic parameters in a population of Romanian children. We conducted a cross-sectional study of 295 Caucasian children, divided according to the body mass index (BMI) z-score into the study (obese and overweight) group of 130 children and the control (normoponderal) group of 165 children. Anthropometric parameters were greater in the obese and overweight population as opposed to controls, with significant differences (p < 0.01) found for the weight (2.77 +/- 1.54 SD vs. -0.04 +/- 1.15 SD), body mass index (BMI) (2.28 +/- 0.97 SD vs. -0.18 +/- 1.19 SD), mid-upper arm circumference (MUAC) (4.59 +/- 2.28 SD vs. 0.28 +/- 3.45 SD), tricipital skin-fold (TSF) (3.31 +/- 3.09 SD vs. 0.62 +/- 7.28 SD) and waist-to-height ratio (WHtR) (0.61 +/- 1.51 SD vs. -0.35 +/- 1.35 SD) z-scores. Moreover, triglyceride values were higher in the study group (118.70 +/- 71.99 SD vs. 77.09 +/- 37.39 SD). No significant difference in the allele and genotype distribution of investigates gene polymorphisms was observed between the studied groups (p > 0.05). PPARG (rs1801282, rs3856806, and rs1800571) were not associated with demographic, anthropometric, and laboratory parameters. However, PPARGC1A rs8192678 CC genotype was associated with TSF z-score (p = 0.03), whereas total and LDL cholesterol levels were significantly higher among TT homozygotes (p < 0.01). Our data suggest that PPARG (rs1801282, rs3856806, and rs1800571) and PPARGC1A (rs8192678) gene polymorphisms were not associated with childhood and adolescence overweight and obesity. The present study identified a significant increase in fasting glucose levels, triglyceride, albumin, and ALT levels in children with excess weight, as well as expected important upward variation of anthropometric parameters (BMI, MUAC, TSF z-scores). Copyright © 2022 Muntean, Sasaran, Crisan and Banescu.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha). 0 (PPAR gamma). 0 (PPARGC1A protein, human). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffpubh.2022.962852
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Muntean&issn=2296-2565&title=Frontiers+in+Public+Health&atitle=Effects+of+PPARG+and+PPARGC1A+gene+polymorphisms+on+obesity+markers.&volume=10&issue=&spage=962852&epage=&date=2022&doi=10.3389%2Ffpubh.2022.962852&pmid=36466447&sid=OVID:medline
+
+<371>
+Unique Identifier
+ 36451189
+Title
+ Pooled prevalence of food away from home (FAFH) and associated non-communicable disease (NCD) markers: a systematic review and meta-analysis. [Review]
+Source
+ Journal of Health, Population & Nutrition. 41(1):55, 2022 11 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Godbharle S; Jeyakumar A; Giri BR; Kesa H
+Authors Full Name
+ Godbharle, Swapnil; Jeyakumar, Angeline; Giri, Bibek Raj; Kesa, Hema.
+Institution
+ Godbharle, Swapnil. Food Evolution Research Laboratory (FERL), School of Tourism and Hospitality Management, College of Business and Economics, University of Johannesburg, Johannesburg, South Africa. swapnilg660@gmail.com.
+ Godbharle, Swapnil. Department of Health Sciences, Savitribai Phule Pune University, Ganeshkhind Road, Pune, Maharashtra, 411007, India. swapnilg660@gmail.com.
+ Jeyakumar, Angeline. Food Evolution Research Laboratory (FERL), School of Tourism and Hospitality Management, College of Business and Economics, University of Johannesburg, Johannesburg, South Africa.
+ Jeyakumar, Angeline. Department of Health Sciences, Savitribai Phule Pune University, Ganeshkhind Road, Pune, Maharashtra, 411007, India.
+ Giri, Bibek Raj. Department of Health Sciences, Savitribai Phule Pune University, Ganeshkhind Road, Pune, Maharashtra, 411007, India.
+ Kesa, Hema. Food Evolution Research Laboratory (FERL), School of Tourism and Hospitality Management, College of Business and Economics, University of Johannesburg, Johannesburg, South Africa.
+MeSH Subject Headings
+ Pregnancy
+ Female
+ Humans
+ Noncommunicable Diseases/ep [Epidemiology]
+ *Noncommunicable Diseases
+ Prevalence
+ Food
+ Biomarkers
+ Diet, Healthy
+ Obesity/ep [Epidemiology]
+ Observational Studies as Topic
+Keyword Heading
+ Anthropometric changes
+ Dietary behavior
+ Food away from home
+ Non-communicable diseases
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Food away from home (FAFH) is an 'eating behavior' widely practiced across nations, more common in developed nations. Likewise, in developing countries an increase of close to 50% indicates an upsurge in FAFH consumption. While various indices and tools are used to assess diet quality, diversity, or healthy eating, FAFH is less utilized to study dietary behaviors and the associated disease risk.
+
+ OBJECTIVE: To calculate the pooled estimate of FAFH and identify the associated non-communicable disease (NCD) markers.
+
+ DESIGN: Systematic review and meta-analysis.
+
+ METHODS: Independent electronic searches were conducted across 6 databases: Medline, Web of Science, Scopus, Cochrane library, Ingenta, and CAB direct. Observational studies investigating the association between FAFH and NCD markers published between the year 2011 and 2021 were eligible for inclusion. Studies that included overweight or obese participants, pregnant women, or those under institutional care at baseline were excluded. The guidelines for reporting meta-analysis of observational studies in epidemiology were adhered to in the preparation of this systematic review.
+
+ RESULTS: The random effects combined estimate for the overall prevalence of FAFH was 39.96% (95% CI 29.97-53.29). High heterogeneity (tau2 = 0.63, I2 = 100%) and high risk of bias were observed among the selected studies. The test for overall effect was observed to be z = 25.11 (p < 0.001). Eleven out of fourteen studies showed a positive association between FAFH and anthropometric changes. Twelve out of seventeen studies showed a positive association between FAFH and cardiovascular disease (CVD) biomarkers.
+
+ CONCLUSION: Our work confirms FAFH as an evolving dietary behavior in both developing and developed countries, emphasizing the lack of representation from low-income countries. The association of FAFH with obesity and non-communicable disease risk is reinforced by our analyses. These findings should enable policy decisions to meet the rising demand of FAFH with healthier options to prevent the risk of NCD. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Meta-Analysis. Systematic Review. Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs41043-022-00335-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Godbharle&issn=1606-0997&title=Journal+of+Health%2C+Population+%26+Nutrition&atitle=Pooled+prevalence+of+food+away+from+home+%28FAFH%29+and+associated+non-communicable+disease+%28NCD%29+markers%3A+a+systematic+review+and+meta-analysis.&volume=41&issue=1&spage=55&epage=&date=2022&doi=10.1186%2Fs41043-022-00335-5&pmid=36451189&sid=OVID:medline
+
+<372>
+Unique Identifier
+ 36451123
+Title
+ Obesity marker trajectories and cognitive impairment in older adults: a 10-year follow-up in Taichung community health study for elders.
+Source
+ BMC Psychiatry. 22(1):748, 2022 11 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li TC; Li CI; Liu CS; Lin CH; Yang SY; Lin CC
+Authors Full Name
+ Li, Tsai-Chung; Li, Chia-Ing; Liu, Chiu-Shong; Lin, Chih-Hsueh; Yang, Shing-Yu; Lin, Cheng-Chieh.
+Institution
+ Li, Tsai-Chung. Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
+ Li, Tsai-Chung. Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan.
+ Li, Chia-Ing. School of Medicine, College of Medicine, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist, Taichung, 406040, Taiwan.
+ Li, Chia-Ing. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
+ Liu, Chiu-Shong. School of Medicine, College of Medicine, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist, Taichung, 406040, Taiwan.
+ Liu, Chiu-Shong. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
+ Liu, Chiu-Shong. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
+ Lin, Chih-Hsueh. School of Medicine, College of Medicine, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist, Taichung, 406040, Taiwan.
+ Lin, Chih-Hsueh. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
+ Yang, Shing-Yu. Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
+ Lin, Cheng-Chieh. School of Medicine, College of Medicine, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist, Taichung, 406040, Taiwan. cclin@mail.cmuh.org.tw.
+ Lin, Cheng-Chieh. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. cclin@mail.cmuh.org.tw.
+ Lin, Cheng-Chieh. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan. cclin@mail.cmuh.org.tw.
+MeSH Subject Headings
+ Aged
+ Humans
+ Biomarkers
+ Cognitive Dysfunction/di [Diagnosis]
+ Cognitive Dysfunction/ep [Epidemiology]
+ *Cognitive Dysfunction
+ Follow-Up Studies
+ Obesity/co [Complications]
+ *Public Health
+Keyword Heading
+ Abdominal fat
+ Cognitive decline
+ Cognitive impairment
+ Fat mass
+ Trajectory
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity and cognitive impairment prevalence increases as age increases. Recent growing evidence finds links between obesity and cognitive impairment in older adults. However, the association between the two is controversial. This study aims to identify obesity marker trajectory patterns, and to assess whether these patterns are associated with cognitive impairment and cognitive decline during a 10-year follow-up period among community-dwelling older adults.
+
+ METHODS: A total of 626 older adults aged 65 and older were involved in the study, with at least two repeated measurements at baseline, one-year or 10-year follow-up. Cognitive function was measured through the Mini Mental State Examination. Obesity markers included body mass index, waist circumference, waist-to-hip (WHR), fat mass (FM), and abdominal fat (AF) measured by dual-energy X-ray absorptiometry. Multivariate logistic regression analyses were performed to estimate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of cognitive impairment and cognitive decline for obesity marker trajectory patterns.
+
+ RESULTS: After a 10-year follow-up, 168 older adults with incident cognitive impairment and 156 with rapid cognitive decline were defined as the top 25th percentile of cognitive decline. Four distinct trajectory groups of obesity markers were identified. In multivariate logistic regression analyses, a low likelihood of cognitive impairment was observed in the consistently high-level group from FM trajectory (ORs = 0.41, 95% CI = 0.20-0.85); the high-level U-shaped group from WHR trajectory (0.43, 0.22-0.84); and the median-level flat inverse U-shaped, consistently high-level, and low-level flat U-shaped groups from AF trajectory (0.44, 0.26-0.77; 0.33, 0.18-0.61; 0.39, 0.18-0.82). In addition, a low likelihood of rapid decline was found in the low-level, slightly increasing trend group from WHR trajectory (0.43, 0.22-0.85).
+
+ CONCLUSION: FM and AF trajectories with consistent high levels and WHR trajectory with high level with U-shaped group are associated with low risks of incident cognitive impairment in older adults. Similarly, WHR trajectory with a low but slowly increasing trend is associated with a decreased risk of cognitive decline. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12888-022-04420-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1471-244X&title=BMC+Psychiatry&atitle=Obesity+marker+trajectories+and+cognitive+impairment+in+older+adults%3A+a+10-year+follow-up+in+Taichung+community+health+study+for+elders.&volume=22&issue=1&spage=748&epage=&date=2022&doi=10.1186%2Fs12888-022-04420-1&pmid=36451123&sid=OVID:medline
+
+<373>
+Unique Identifier
+ 36407366
+Title
+ Sensitivity, specificity of biochemical markers for early prediction of endothelial dysfunction in atherosclerotic obese subjects.
+Source
+ African Health Sciences. 22(2):286-294, 2022 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abulnaja KO; Kannan K; Al-Manzlawi AMK; Kumosani TA; Qari M; Moselhy SS
+Authors Full Name
+ Abulnaja, Khalid O; Kannan, Kurunthachalam; Al-Manzlawi, Ashgan Mohammed K; Kumosani, Taha A; Qari, Mohamed; Moselhy, Said S.
+Institution
+ Abulnaja, Khalid O. Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Abulnaja, Khalid O. Experimental Biochemistry Unit, King Fahd Medical Research Center, KAU.
+ Kannan, Kurunthachalam. Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Kannan, Kurunthachalam. Department of Pediatric, New York, University School of medicine, New York, NY 10016, USA.
+ Al-Manzlawi, Ashgan Mohammed K. Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Kumosani, Taha A. Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Kumosani, Taha A. Experimental Biochemistry Unit, King Fahd Medical Research Center, KAU.
+ Kumosani, Taha A. Production of Bio-products for Industrial Applications Research Group, KAU.
+ Qari, Mohamed. Department of Hematology, Faculty of Medical Science, King Abdulaziz University, Jeddah.
+ Moselhy, Said S. Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
+MeSH Subject Headings
+ Humans
+ Male
+ *E-Selectin
+ Vascular Cell Adhesion Molecule-1
+ Intercellular Adhesion Molecule-1
+ Obesity
+ Biomarkers
+ Atherosclerosis/di [Diagnosis]
+ *Atherosclerosis
+Keyword Heading
+ Obesity
+ atherosclerosis
+ endothelial dysfunction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: The obesity increased incidence of diabetes, hypertension and atherosclerosis and rate of morbidity and mortality. The main cause of atherosclerosis is endothelial dysfunction and formation of foam cells and macrophage that lead to unfavorable complications. This study evaluated specific biomarkers for endothelial dysfunction as sensitive indices for early predication of atherosclerosis in obese subjects.
+
+ Study Design: One hundred fifty male age and sex matching were included in the current study divided into three groups according to body mass index (BMI): Control (BMI <= 22), obese (BMI> 28) and obese with atherosclerosis (BMI> 28). Fasting serum was subjected for determination of adhesion molecules, sICAM-1, sVCAM-1, E-selectin, oxo-LDL and 8-iso-PGF2alpha by ELISA technique.
+
+ Results: Data obtained showed that, a significant elevation of serum inflammatory markers CRP, IL-6 and TNF-alpha and adhesion molecules sICAM-1 (p<0.001) with sensitivity 96%, sVCAM-1 (p <0.01) with sensitivity 92%, E-selectin (p<0.001) with sensitivity 94%, oxo-LDL (p <0.05) and 8-iso-PGF2alpha (p < 0.001) with sensitivity 97% in obese with atherosclerosis compared with obese and control.
+
+ Conclusion: The levels of serum adhesion molecules contributed in the pathogenesis of endothelial dysfunction can be used as sensitive biomarkers for early prediction of atherosclerosis in obese subjects. Copyright © 2022 Abulnaja KO et al.
+Registry Number/Name of Substance
+ 0 (E-Selectin). 0 (Vascular Cell Adhesion Molecule-1). 126547-89-5 (Intercellular Adhesion Molecule-1). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.4314%2fahs.v22i2.32
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abulnaja&issn=1680-6905&title=African+Health+Sciences&atitle=Sensitivity%2C+specificity+of+biochemical+markers+for+early+prediction+of+endothelial+dysfunction+in+atherosclerotic+obese+subjects.&volume=22&issue=2&spage=286&epage=294&date=2022&doi=10.4314%2Fahs.v22i2.32&pmid=36407366&sid=OVID:medline
+
+<374>
+Unique Identifier
+ 36401194
+Title
+ Associations between circulating obesity-related biomarkers and prognosis in female breast cancer survivors: a systematic review of observational data in women enrolled in lifestyle intervention trials.
+Source
+ BMC Cancer. 22(1):1187, 2022 Nov 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Meyer D; Pastor-Villaescusa B; Michel S; Hauner H; Hauner D
+Authors Full Name
+ Meyer, Dorothy; Pastor-Villaescusa, Belen; Michel, Sophie; Hauner, Hans; Hauner, Dagmar.
+Institution
+ Meyer, Dorothy. Institute of Nutritional Medicine, Else Kroner-Fresenius-Centre for Nutritional Medicine, School of Medicine, Technical University of Munich, Georg-Brauchle-Ring 62, 80992, Munich, Germany.
+ Pastor-Villaescusa, Belen. Institute of Nutritional Medicine, Else Kroner-Fresenius-Centre for Nutritional Medicine, School of Medicine, Technical University of Munich, Georg-Brauchle-Ring 62, 80992, Munich, Germany.
+ Michel, Sophie. Institute of Nutritional Medicine, Else Kroner-Fresenius-Centre for Nutritional Medicine, School of Medicine, Technical University of Munich, Georg-Brauchle-Ring 62, 80992, Munich, Germany.
+ Hauner, Hans. Institute of Nutritional Medicine, Else Kroner-Fresenius-Centre for Nutritional Medicine, School of Medicine, Technical University of Munich, Georg-Brauchle-Ring 62, 80992, Munich, Germany. hans.hauner@tum.de.
+ Hauner, Dagmar. Institute of Nutritional Medicine, Else Kroner-Fresenius-Centre for Nutritional Medicine, School of Medicine, Technical University of Munich, Georg-Brauchle-Ring 62, 80992, Munich, Germany.
+MeSH Subject Headings
+ Humans
+ Female
+ *Breast Neoplasms
+ *Cancer Survivors
+ Exercise
+ Neoplasm Recurrence, Local/co [Complications]
+ Prognosis
+ Life Style
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Obesity/me [Metabolism]
+ Biomarkers
+Keyword Heading
+ Biomarker
+ Breast cancer mortality
+ Breast cancer recurrence
+ Disease-free survival
+ Obesity
+ Systematic review
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity plays an important role in the development and progression of breast cancer via various oncogenic pathways. However, the biological mechanisms underlying this relationship are not fully understood. Moreover, it is unclear whether obesity-related and further associated biomarkers could be suitable targets for lifestyle interventions. This systematic review was conducted to examine relationships between obesity-related blood parameters and prognosis for breast cancer survivors enrolled in lifestyle intervention studies. A systematic, computerized literature search was conducted from inception through August 26th, 2020 in PubMed, EMBASE, and CENTRAL. The focus was on observational data from randomized controlled lifestyle intervention trials investigating associations between selected baseline biomarkers, measured in remission, and breast cancer recurrence, breast cancer mortality and/or all-cause mortality. Four studies with data from 5234 women met the inclusion criteria.Studies herein provide moderate evidence that bioavailable or serum testosterone may be positively linked to breast cancer recurrence and inversely linked to disease-free survival. Limited evidence suggests no associations with circulating estradiol or insulin levels on prognosis outcomes, whereas HDL cholesterol was inversely associated with breast cancer recurrence. For some other biomarkers, such as growth factors, adipokines, and CRP, the evidence for associations with disease prognosis was too weak to draw conclusions.Overall, despite potential candidates, there is insufficient evidence to confirm or refute that obesity-related biomarkers and sex hormones have a prognostic value for breast cancer survival. More longitudinal studies in breast cancer survivors to examine the clinical utility of obesity-related biomarkers are needed. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Systematic Review. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12885-022-10274-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Meyer&issn=1471-2407&title=BMC+Cancer&atitle=Associations+between+circulating+obesity-related+biomarkers+and+prognosis+in+female+breast+cancer+survivors%3A+a+systematic+review+of+observational+data+in+women+enrolled+in+lifestyle+intervention+trials.&volume=22&issue=1&spage=1187&epage=&date=2022&doi=10.1186%2Fs12885-022-10274-3&pmid=36401194&sid=OVID:medline
+
+<375>
+Unique Identifier
+ 36364860
+Title
+ Docosahexaenoic Acid Counteracts the Hypoxic-Induced Inflammatory and Metabolic Alterations in 3T3-L1 Adipocytes.
+Source
+ Nutrients. 14(21), 2022 Nov 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Younes NB; Mohamed OA; Rizk NM
+Author NameID
+ Rizk, Nasser M; ORCID: https://orcid.org/0000-0002-6288-3609
+Authors Full Name
+ Younes, Noura B; Mohamed, Omnia Ahmed; Rizk, Nasser M.
+Institution
+ Younes, Noura B. Biomedical Sciences Department, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
+ Younes, Noura B. Clinical Chemistry Laboratory, Hamad Medical Corporation, Doha 2713, Qatar.
+ Mohamed, Omnia Ahmed. Biomedical Sciences Department, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
+ Rizk, Nasser M. Biomedical Sciences Department, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
+ Rizk, Nasser M. Biomedical Research Center (BRC), Qatar University, Doha 2713, Qatar.
+MeSH Subject Headings
+ Mice
+ Animals
+ 3T3-L1 Cells
+ Docosahexaenoic Acids/pd [Pharmacology]
+ Docosahexaenoic Acids/me [Metabolism]
+ *Docosahexaenoic Acids
+ Leptin/me [Metabolism]
+ *Leptin
+ Glucose Transporter Type 1/ge [Genetics]
+ Glucose Transporter Type 1/me [Metabolism]
+ Adiponectin/me [Metabolism]
+ Reactive Oxygen Species/me [Metabolism]
+ Adipocytes
+ Inflammation/dt [Drug Therapy]
+ Inflammation/me [Metabolism]
+ Hypoxia/me [Metabolism]
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Adipokines/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Lactates/me [Metabolism]
+ Adenosine Triphosphate/me [Metabolism]
+Keyword Heading
+ 3T3-L1 cell adipocytes
+ adipokines
+ docosahexaenoic acid (DHA)
+ hypoxia
+ metabolism
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hypoxia is caused by the excessive expansion of the white adipose tissue (AT) and is associated with obesity-related conditions such as insulin resistance, inflammation, and oxidative stress. Docosahexaenoic acid (DHA) is an omega-3 fatty acid reported to have beneficial health effects. However, the effects of DHA in AT against hypoxia-induced immune-metabolic perturbations in adipocytes exposed to low O2 tension are not well known. Consequently, this study aimed to evaluate the impact of DHA on markers of inflammation, metabolism, apoptosis, and oxidative stress in 3T3-L1 cell adipocytes exposed to low O2 tension (1% O2) induced hypoxia.
+
+ METHODS: The apoptosis and reactive oxygen species (ROS) rates were evaluated. Metabolic parameters such as lactate, FFA, glycerol release, glucose uptake, and ATP content were assessed by a fluorometer. The expression of HIF-1, GLUT1 and the secretion of adipocytokines such as leptin, adiponectin, and pro-inflammatory markers was evaluated.
+
+ RESULTS: DHA-treated hypoxic cells showed significantly decreased basal free fatty acid release, lactate production, and enhanced glucose consumption. In addition, DHA-treatment of hypoxic cells caused a significant reduction in the apoptosis rate and ROS production with decreased lipid peroxidation. Moreover, DHA-treatment of hypoxic cells caused a decreased secretion of pro-inflammatory markers (IL-6, MCP-1) and leptin and increased adiponectin secretion compared with hypoxic cells. Furthermore, DHA-treatment of hypoxic cells caused significant reductions in the expression of genes related to hypoxia (HIF-1, HIF-2), anaerobic metabolism (GLUT1 and Ldha), ATP production (ANT2), and fat metabolism (FASN and PPARY).
+
+ CONCLUSION: This study suggests that DHA can exert potential anti-obesity effects by reducing the secretion of inflammatory adipokines, oxidative stress, lipolysis, and apoptosis.
+Registry Number/Name of Substance
+ 25167-62-8 (Docosahexaenoic Acids). 0 (Leptin). 0 (Glucose Transporter Type 1). 0 (Adiponectin). 0 (Reactive Oxygen Species). 0 (Adipokines). 0 (Biomarkers). 0 (Lactates). 8L70Q75FXE (Adenosine Triphosphate).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14214600
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Younes&issn=2072-6643&title=Nutrients&atitle=Docosahexaenoic+Acid+Counteracts+the+Hypoxic-Induced+Inflammatory+and+Metabolic+Alterations+in+3T3-L1+Adipocytes.&volume=14&issue=21&spage=&epage=&date=2022&doi=10.3390%2Fnu14214600&pmid=36364860&sid=OVID:medline
+
+<376>
+Unique Identifier
+ 36363468
+Title
+ Changes in Left Heart Geometry, Function, and Blood Serum Biomarkers in Patients with Obstructive Sleep Apnea after Treatment with Continuous Positive Airway Pressure.
+Source
+ Medicina (Kaunas, Lithuania). 58(11), 2022 Oct 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kondrataviciene L; Tamulenaite E; Vasyle E; Januskevicius A; Ereminiene E; Malakauskas K; Zemaitis M; Miliauskas S
+Author NameID
+ Kondrataviciene, Laima; ORCID: https://orcid.org/0000-0001-6384-9392
+Authors Full Name
+ Kondrataviciene, Laima; Tamulenaite, Egle; Vasyle, Egle; Januskevicius, Andrius; Ereminiene, Egle; Malakauskas, Kestutis; Zemaitis, Marius; Miliauskas, Skaidrius.
+Institution
+ Kondrataviciene, Laima. Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
+ Tamulenaite, Egle. Department of Cardiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
+ Vasyle, Egle. Laboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
+ Januskevicius, Andrius. Laboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
+ Ereminiene, Egle. Department of Cardiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
+ Malakauskas, Kestutis. Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
+ Zemaitis, Marius. Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
+ Miliauskas, Skaidrius. Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
+MeSH Subject Headings
+ Humans
+ Continuous Positive Airway Pressure/mt [Methods]
+ Serum
+ Galectin 3
+ Polysomnography
+ Sleep Apnea, Obstructive/co [Complications]
+ Sleep Apnea, Obstructive/th [Therapy]
+ *Sleep Apnea, Obstructive
+ *Ventricular Dysfunction, Left
+ Biomarkers
+ Obesity/co [Complications]
+Keyword Heading
+ continuous positive airway pressure
+ endothelin-1
+ galectin-3
+ obstructive sleep apnea
+ sST2
+ two-dimensional speckle-tracking echocardiography
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Cardiovascular remodeling is essential in patients with obstructive sleep apnea (OSA), and continuous positive airway pressure (CPAP) therapy could improve these processes. Two-dimensional (2D) speckle-tracking (ST) echocardiography is a useful method for subclinical biventricular dysfunction diagnosis and thus might help as an earlier treatment for OSA patients. It is still not clear which blood serum biomarkers could be used to assess CPAP treatment efficacy. Objectives: To evaluate left heart geometry, function, deformation parameters, and blood serum biomarker (galectin-3, sST2, endothelin-1) levels in patients with OSA, as well as to assess changes after short-term CPAP treatment. Materials and Methods: Thirty-four patients diagnosed with moderate or severe OSA, as well as thirteen patients as a control group, were included in the study. All the subjects were obese (body mass index (BMI) > 30 kg/m2). Transthoracic 2D ST echocardiography was performed before and after 3 months of treatment with CPAP; for the control group, at baseline only. Peripheral blood samples for the testing of biomarkers were collected at the time of study enrolment before the initiation of CPAP therapy and after 3 months of CPAP treatment (blood samples were taken just for OSA group patients). Results: The left ventricle (LV) end-diastolic diameter and volume, as well as LV ejection fraction (EF), did not differ between groups, but an increased LV end-systolic volume and a reduced LV global longitudinal strain (GLS) were found in the OSA group patients (p = 0.015 and p = 0.035, respectively). Indexed by height, higher LV MMi in OSA patients (p = 0.007) and a higher prevalence of LV diastolic dysfunction (p = 0.023) were found in this group of patients. Although left atrium (LA) volume did not differ between groups, OSA group patients had significantly lower LA reservoir strain (p < 0.001). Conventional RV longitudinal and global function parameters (S', fractional area change (FAC)) did not differ between groups; however, RV GLS was reduced in OSA patients (p = 0.026). OSA patients had a significantly higher right atrium (RA) diameter and mean pulmonary artery pressure (PAP) (p < 0.05). Galectin-3 and sST2 concentrations significantly decreased after 3 months of CPAP treatment. Conclusions : OSA is associated with the left heart remodeling process-increased LV myocardial mass index, LV diastolic dysfunction, reduced LV and RV longitudinal strain, and reduced LA reservoir function. A short-term, 3-months CPAP treatment improves LV global longitudinal strain and LA reservoir function and positively affects blood serum biomarkers. This new indexing system for LV myocardial mass by height helps to identify myocardial structural changes in obese patients with OSA.
+Registry Number/Name of Substance
+ 0 (Galectin 3). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fmedicina58111511
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kondrataviciene&issn=1010-660X&title=Medicina+%28Kaunas%2C+Lithuania%29&atitle=Changes+in+Left+Heart+Geometry%2C+Function%2C+and+Blood+Serum+Biomarkers+in+Patients+with+Obstructive+Sleep+Apnea+after+Treatment+with+Continuous+Positive+Airway+Pressure.&volume=58&issue=11&spage=1511&epage=&date=2022&doi=10.3390%2Fmedicina58111511&pmid=36363468&sid=OVID:medline
+
+<377>
+Unique Identifier
+ 36362225
+Title
+ The New Markers of Early Obesity-Related Organ and Metabolic Abnormalities.
+Source
+ International Journal of Molecular Sciences. 23(21), 2022 Nov 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ziomber-Lisiak A; Piana K; Ostachowicz B; Wrobel P; Kasprzyk P; Kaszuba-Zwoinska J; Baranowska-Chowaniec A; Juszczak K; Szczerbowska-Boruchowska M
+Author NameID
+ Kasprzyk, Paula; ORCID: https://orcid.org/0000-0002-6072-5869
+ Szczerbowska-Boruchowska, Magdalena; ORCID: https://orcid.org/0000-0002-8331-1917
+Authors Full Name
+ Ziomber-Lisiak, Agata; Piana, Kaja; Ostachowicz, Beata; Wrobel, Pawel; Kasprzyk, Paula; Kaszuba-Zwoinska, Jolanta; Baranowska-Chowaniec, Agnieszka; Juszczak, Kajetan; Szczerbowska-Boruchowska, Magdalena.
+Institution
+ Ziomber-Lisiak, Agata. Chair of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, ul. Czysta 18, 31-121 Krakow, Poland.
+ Piana, Kaja. Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland.
+ Ostachowicz, Beata. Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland.
+ Wrobel, Pawel. Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland.
+ Kasprzyk, Paula. Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland.
+ Kaszuba-Zwoinska, Jolanta. Chair of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, ul. Czysta 18, 31-121 Krakow, Poland.
+ Baranowska-Chowaniec, Agnieszka. Chair of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, ul. Czysta 18, 31-121 Krakow, Poland.
+ Juszczak, Kajetan. Department of Urology and Andrology, Collegium Medicum, Nicolaus Copernicus University, ul. M. Curie Sklodowskiej 9, 85-094 Bydgoszcz, Poland.
+ Szczerbowska-Boruchowska, Magdalena. Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland.
+MeSH Subject Headings
+ Rats
+ Animals
+ Obesity/me [Metabolism]
+ *Obesity
+ Fibroblast Growth Factors/me [Metabolism]
+ *Fibroblast Growth Factors
+ Adiposity
+ Energy Intake
+ Biomarkers/me [Metabolism]
+Keyword Heading
+ FGF-19
+ FGF-21
+ TXRF technique
+ high-calorie diet
+ obesity
+ rat
+ rubidium
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The objective of our study was to identify new markers related to excessive body adiposity and its early consequences. For this purpose we determined serum FGF-19 and FGF-21 concentrations in obese rats, whose role in the pathogenesis of obesity is not yet established. In addition, a total reflection X-ray fluorescence technique was applied to determine the elemental chemistry of certain tissues affected by obesity. Next, the new biochemical and molecular parameters were correlated with well-known obesity-related markers of metabolic abnormalities. Our obese rats were characterized by increased calorie consumption and body adiposity, hypercholesterolemia, elevated levels of liver enzymes and FGF-21, while the level of FGF-19 was reduced. Strong relationships between new hormones and established metabolic parameters were observed. Furthermore, we demonstrated that obesity had the greatest effect on elemental composition in the adipose tissue and liver and that rubidium (Rb) had the highest importance in distinguishing the studied groups of animals. Tissue Rb strongly correlated with both well-known and new markers of obesity. In conclusion, we confirmed serum FGF-19 and FGF-21 as useful new markers of obesity-related metabolic alternations and we robustly propose Rb as a novel indicator of excessive body adiposity and its early consequences. However, further investigations are encouraged to address this clinical issue.
+Registry Number/Name of Substance
+ 62031-54-3 (Fibroblast Growth Factors). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms232113437
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ziomber-Lisiak&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=The+New+Markers+of+Early+Obesity-Related+Organ+and+Metabolic+Abnormalities.&volume=23&issue=21&spage=13437&epage=&date=2022&doi=10.3390%2Fijms232113437&pmid=36362225&sid=OVID:medline
+
+<378>
+Unique Identifier
+ 36360814
+Title
+ Carotid Plaque Features and Inflammatory Biomarkers as Predictors of Restenosis and Mortality Following Carotid Endarterectomy.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 19(21), 2022 10 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Niculescu R; Russu E; Arbanasi EM; Kaller R; Arbanasi EM; Melinte RM; Cosarca CM; Cocuz IG; Sabau AH; Tinca AC; Stoian A; Vunvulea V; Muresan AV; Cotoi OS
+Author NameID
+ Arbanasi, Emil Marian; ORCID: https://orcid.org/0000-0002-1664-8130
+ Cocuz, Iuliu Gabriel; ORCID: https://orcid.org/0000-0001-5985-2433
+ Stoian, Adina; ORCID: https://orcid.org/0000-0001-6862-4926
+Authors Full Name
+ Niculescu, Raluca; Russu, Eliza; Arbanasi, Emil Marian; Kaller, Reka; Arbanasi, Eliza Mihaela; Melinte, Razvan Marian; Cosarca, Catalin Mircea; Cocuz, Iuliu Gabriel; Sabau, Adrian Horatiu; Tinca, Andreea Catalina; Stoian, Adina; Vunvulea, Vlad; Muresan, Adrian Vasile; Cotoi, Ovidiu Simion.
+Institution
+ Niculescu, Raluca. Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.
+ Niculescu, Raluca. Department of Pathology, Mures Clinical County Hospital, 540011 Targu Mures, Romania.
+ Russu, Eliza. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Russu, Eliza. Department of Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139, Targu Mures, Romania.
+ Arbanasi, Emil Marian. Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.
+ Arbanasi, Emil Marian. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Kaller, Reka. Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.
+ Kaller, Reka. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Arbanasi, Eliza Mihaela. Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Melinte, Razvan Marian. Department of Orthopedics, Regina Maria Health Network, 540098 Targu Mures, Romania.
+ Melinte, Razvan Marian. Department of Orthopedics, Humanitas MedLife Hospital, 400664 Cluj Napoca, Romania.
+ Cosarca, Catalin Mircea. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Cocuz, Iuliu Gabriel. Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.
+ Cocuz, Iuliu Gabriel. Department of Pathology, Mures Clinical County Hospital, 540011 Targu Mures, Romania.
+ Sabau, Adrian Horatiu. Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.
+ Sabau, Adrian Horatiu. Department of Pathology, Mures Clinical County Hospital, 540011 Targu Mures, Romania.
+ Tinca, Andreea Catalina. Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.
+ Tinca, Andreea Catalina. Department of Pathology, Mures Clinical County Hospital, 540011 Targu Mures, Romania.
+ Stoian, Adina. Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Vunvulea, Vlad. Department of Radiology, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Muresan, Adrian Vasile. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Muresan, Adrian Vasile. Department of Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139, Targu Mures, Romania.
+ Cotoi, Ovidiu Simion. Department of Pathology, Mures Clinical County Hospital, 540011 Targu Mures, Romania.
+ Cotoi, Ovidiu Simion. Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania.
+MeSH Subject Headings
+ Humans
+ Adolescent
+ Adult
+ Endarterectomy, Carotid/ae [Adverse Effects]
+ Endarterectomy, Carotid/mt [Methods]
+ *Endarterectomy, Carotid
+ Retrospective Studies
+ *Hydroxymethylglutaryl-CoA Reductase Inhibitors
+ Recurrence
+ Carotid Stenosis/su [Surgery]
+ *Carotid Stenosis
+ Biomarkers
+ Constriction, Pathologic/et [Etiology]
+ Inflammation/et [Etiology]
+ Obesity/et [Etiology]
+Keyword Heading
+ AISI
+ MLR
+ NLR
+ PLR
+ SII
+ SIRI
+ biomarkers
+ carotid plaque
+ carotid restenosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Carotid endarterectomy (CEA) is the first-line surgical intervention for cases of severe carotid stenoses. Unfortunately, the restenosis rate is high after CEA. This study aims to demonstrate the predictive role of carotid plaque features and inflammatory biomarkers (monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic inflammatory index (SII), Systemic Inflammation Response Index (SIRI), and Aggregate Index of Systemic Inflammation (AISI)) in carotid restenosis and mortality at 12 months following CEA.
+
+ METHODS: The present study was designed as an observational, analytical, retrospective cohort study and included all patients over 18 years of age with a minimum of 70% carotid stenosis and surgical indications for CEA admitted to the Vascular Surgery Clinic, Emergency County Hospital of Targu Mures, Romania between 2018 and 2021.
+
+ RESULTS: According to our results, the high pre-operative values of inflammatory biomarkers-MLR (OR: 10.37 and OR: 6.11; p < 0.001), NLR (OR: 34.22 and OR: 37.62; p < 0.001), PLR (OR: 12.02 and OR: 16.06; p < 0.001), SII (OR: 18.11 and OR: 31.70; p < 0.001), SIRI (OR: 16.64 and OR: 9.89; p < 0.001), and AISI (OR: 16.80 and OR: 8.24; p < 0.001)-are strong independent factors predicting the risk of 12-month restenosis and mortality following CEA. Moreover, unstable plaque (OR: 2.83, p < 0.001 and OR: 2.40, p = 0.04) and MI (OR: 3.16, p < 0.001 and OR: 2.83, p = 0.005) were independent predictors of all outcomes. Furthermore, AH (OR: 2.30; p = 0.006), AF (OR: 1.74; p = 0.02), tobacco (OR: 2.25; p < 0.001), obesity (OR: 1.90; p = 0.02), and thrombotic plaques (OR: 2.77; p < 0.001) were all independent predictors of restenosis, but not for mortality in all patients. In contrast, antiplatelet (OR: 0.46; p = 0.004), statin (OR: 0.59; p = 0.04), and ezetimibe (OR:0.45; p = 0.03) therapy were protective factors against restenosis, but not for mortality.
+
+ CONCLUSIONS: Our data revealed that higher preoperative inflammatory biomarker values highly predict 12-month restenosis and mortality following CEA. Furthermore, age above 70, unstable plaque, cardiovascular disease, and dyslipidemia were risk factors for all outcomes. Additionally, AH, AF, smoking, and obesity were all independent predictors of restenosis but not of mortality in all patients. Antiplatelet and statin medication, on the other hand, were protective against restenosis but not against mortality.
+Registry Number/Name of Substance
+ 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijerph192113934
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Niculescu&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Carotid+Plaque+Features+and+Inflammatory+Biomarkers+as+Predictors+of+Restenosis+and+Mortality+Following+Carotid+Endarterectomy.&volume=19&issue=21&spage=&epage=&date=2022&doi=10.3390%2Fijerph192113934&pmid=36360814&sid=OVID:medline
+
+<379>
+Unique Identifier
+ 36355053
+Title
+ Impact of testosterone therapy on bone turnover markers in obese males with type 2 diabetes and functional hypogonadism.
+Source
+ Aging Male. 25(1):269-277, 2022 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Groti Antonic K
+Author NameID
+ Groti Antonic, Kristina; ORCID: https://orcid.org/0000-0002-4078-0238
+Authors Full Name
+ Groti Antonic, Kristina.
+Institution
+ Groti Antonic, Kristina. Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.
+ Groti Antonic, Kristina. Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
+MeSH Subject Headings
+ Male
+ Humans
+ Bone Remodeling
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 2
+ Biomarkers
+ Bone Density
+ Hypogonadism/co [Complications]
+ Hypogonadism/dt [Drug Therapy]
+ *Hypogonadism
+ Collagen Type I
+ Testosterone
+ Lumbar Vertebrae/dg [Diagnostic Imaging]
+ Obesity/co [Complications]
+ Obesity/dt [Drug Therapy]
+Keyword Heading
+ Type 2 diabetes
+ bone mineral density
+ fracture
+ hypogonadism
+ osteoporosis
+ testosterone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ METHODS: Fifty-five obese males with type 2 diabetes mellitus and functional hypogonadism participated in a 2-year, double-blind, placebo-controlled study of testosterone undecanoate (TU). Bone turnover markers C-telopeptide of type I collagen (CTX) and procollagen I N-terminal propeptide (PINP) were assessed at baseline, 12 and 24 months. Bone mineral density (BMD) changes were evaluated after 24 months using dual-energy X-ray absorptiometry. Group T (n = 28) received TU both years. Group P (n = 27) received placebo first year and TU second year.
+
+ RESULTS: CTX decreased in group P from 1055 (676-1344) to 453 (365-665) pmol/L (p < 0.001) and from 897 (679-1506) to 523 (364-835) pmol/L (p < 0.001) in T. PINP decreased by 4.30 +/- 8.05 mug/L in group P (p = 0.030) and 4.64 +/- 8.86 mug/L in T (p < 0.023) after first year of therapy. No femoral neck BMD changes were observed in 32 patients from both groups (n = 16 per group). Lumbar spine BMD increased (by 0.075 +/- 0.114 g/cm2; p = 0.019) in group T following two years of treatment.
+
+ CONCLUSIONS: We observed decreased CTX, decreased PINP and increased lumbar spine BMD after two years of testosterone treatment.
+
+ CLINICAL TRIALS: NCT03792321; retrospectively registered trial on 4 January 2019.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Collagen Type I). 3XMK78S47O (Testosterone).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1080%2f13685538.2022.2134338
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Groti+Antonic&issn=1368-5538&title=Aging+Male&atitle=Impact+of+testosterone+therapy+on+bone+turnover+markers+in+obese+males+with+type+2+diabetes+and+functional+hypogonadism.&volume=25&issue=1&spage=269&epage=277&date=2022&doi=10.1080%2F13685538.2022.2134338&pmid=36355053&sid=OVID:medline
+
+<380>
+Unique Identifier
+ 36352412
+Title
+ Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident cardiovascular disease.
+Source
+ BMC Medicine. 20(1):383, 2022 11 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tian X; Chen S; Zuo Y; Zhang Y; Zhang X; Xu Q; Luo Y; Wu S; Wang A
+Authors Full Name
+ Tian, Xue; Chen, Shuohua; Zuo, Yingting; Zhang, Yijun; Zhang, Xiaoli; Xu, Qin; Luo, Yanxia; Wu, Shouling; Wang, Anxin.
+Institution
+ Tian, Xue. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Tian, Xue. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Tian, Xue. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China.
+ Tian, Xue. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
+ Chen, Shuohua. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, 57 Xinhua East Rd, Tangshan, 063000, China.
+ Zuo, Yingting. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Zuo, Yingting. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Zhang, Yijun. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Zhang, Yijun. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Zhang, Xiaoli. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Zhang, Xiaoli. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Xu, Qin. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
+ Xu, Qin. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
+ Luo, Yanxia. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. lyx100@ccmu.edu.cn.
+ Luo, Yanxia. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China. lyx100@ccmu.edu.cn.
+ Wu, Shouling. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, 57 Xinhua East Rd, Tangshan, 063000, China. drwusl@163.com.
+ Wang, Anxin. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. wanganxin@bjtth.org.
+ Wang, Anxin. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. wanganxin@bjtth.org.
+MeSH Subject Headings
+ Humans
+ Aged
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Overweight/co [Complications]
+ *Insulin Resistance
+ Cohort Studies
+ Age of Onset
+ Risk Factors
+ Hypertension/co [Complications]
+ *Hypertension
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus
+ Obesity/co [Complications]
+ Biomarkers
+ Dyslipidemias/co [Complications]
+ *Dyslipidemias
+ Triglycerides
+ Incidence
+Keyword Heading
+ Age-related risk
+ Cardiovascular disease
+ Risk factors
+ Young adults
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Risk profiles for premature cardiovascular disease (CVD) are unclear. This study aimed to examine baseline risk profiles for incident CVD by age at onset in Chinese population.
+
+ METHODS: A total of 97,841 participants without CVD were enrolled from the Kailuan cohort study. Four age groups were examined (< 55, 55 to < 65, 65 to < 75, and >= 75 years) for CVD onset. Risk profiles included clinical, lipid, metabolic, and inflammatory risk factors and biomarkers.
+
+ RESULTS: Of the clinical factors, diabetes was associated with the highest relative risk for incident CVD in participants younger than 55 years (sub-distributional hazard ratio [sHR], 4.08; 95% confidence interval [CI], 3.47-4.80). Risk factors that were also noted for CVD onset in participants younger than 55 years included hypertension, metabolism syndrome, overweight or obese, dyslipidemia, and smoking. Among the biomarkers, insulin resistance measured by triglyceride-glucose index had the highest sHR (1.42; 95% CI, 1.35-1.49) for CVD in participants younger than 55 years. In comparison, weaker but significant associations with CVD in participants younger than 55 years were noted for most lipids, metabolic biomarkers, and inflammatory biomarkers. Most risk factors and biomarkers had associations that attenuated with increasing age at onset. Some biomarkers had similar CVD age association, while a few had no association with CVD onset at any age.
+
+ CONCLUSIONS: These findings showed that diabetes and insulin resistance, in addition to hypertension, metabolism syndrome, overweight or obese, dyslipidemia, and smoking, appeared to be the strongest risk factors for premature onset of CVD, and most risk factors had attenuated relative rates at older ages. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12916-022-02592-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tian&issn=1741-7015&title=BMC+Medicine&atitle=Association+of+lipid%2C+inflammatory%2C+and+metabolic+biomarkers+with+age+at+onset+for+incident+cardiovascular+disease.&volume=20&issue=1&spage=383&epage=&date=2022&doi=10.1186%2Fs12916-022-02592-x&pmid=36352412&sid=OVID:medline
+
+<381>
+Unique Identifier
+ 36329496
+Title
+ Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology.
+Source
+ Alzheimer's Research & Therapy. 14(1):165, 2022 11 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim KY; Ha J; Kim M; Cho SY; Kim H; Kim E
+Corporate Author
+ Alzheimer's Disease Neuroimaging Initiative
+Authors Full Name
+ Kim, Keun You; Ha, Junghee; Kim, Minae; Cho, So Yeon; Kim, Hyunjeong; Kim, Eosu.
+Institution
+ Kim, Keun You. Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
+ Kim, Keun You. Department of Psychiatry, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
+ Ha, Junghee. Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
+ Kim, Minae. Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
+ Cho, So Yeon. Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
+ Cho, So Yeon. Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
+ Kim, Hyunjeong. Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
+ Kim, Hyunjeong. Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
+ Kim, Eosu. Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea. eosu.kim@yonsei.ac.kr.
+ Kim, Eosu. Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea. eosu.kim@yonsei.ac.kr.
+MeSH Subject Headings
+ Female
+ Humans
+ Male
+ Amyloid beta-Peptides
+ Alzheimer Disease/pa [Pathology]
+ *Alzheimer Disease
+ Adiponectin
+ Leptin
+ Cerebral Cortical Thinning
+ Longitudinal Studies
+ Cognitive Dysfunction/px [Psychology]
+ *Cognitive Dysfunction
+ Biomarkers
+ Obesity
+Keyword Heading
+ Adiponectin
+ Alzheimer's disease
+ Beta-amyloid
+ Cortical thickness
+ Leptin
+ Mild cognitive impairment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Blood adiponectin and leptin are adipokines that emerged as potential biomarkers for predicting Alzheimer's disease (AD) owing to their strong connection with obesity. Although obesity affects the relation between beta-amyloid (Abeta) aggregation and cognitive decline, the longitudinal interactive effect of adipokines and Abeta on cognition and brain structures in humans remains unexplored. Hence, we investigated whether plasma levels of adiponectin and leptin are associated with future cognitive decline and cortical thinning across Abeta conditions (Abeta [+] and Abeta [-]) in individuals with mild cognitive impairment (MCI).
+
+ METHODS: Of 156 participants with MCI from the longitudinal cohort study of Alzheimer's Disease Neuroimaging Initiative (ADNI), 31 were Abeta (-) and 125 were Abeta (+) as determined by CSF analysis. The Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) scores and the thickness of the parahippocampal and entorhinal cortices were used to evaluate cognition and brain structure, respectively. After stratifying groups by Abeta conditions, the association of cognitive and brain structural changes with baseline plasma levels of adiponectin and leptin was examined.
+
+ RESULTS: Of the total 156 participants, 51 were women (32.7%). The mean age of participants was 74.5 (standard deviation 7.57), and the mean follow-up period was 54.3 months, without a difference between the Abeta (+) and (-) groups. After adjustment for confounders, higher plasma adiponectin levels were associated with a faster increase in ADAS-Cog scores, indicating faster cognitive decline under the Abeta (+) condition (beta = 0.224, p = 0.018). Likewise, participants with higher plasma adiponectin presented faster cortical thinning in the bilateral parahippocampal cortices under the Abeta (+) condition (beta = - 0.004, p = 0.012 for the right side; beta = - 0.004, p = 0.025 for the left side). Interestingly, plasma adiponectin levels were not associated with longitudinal ADAS-Cog scores or cortical thickness in the Abeta (-) condition. Plasma leptin levels were not predictive of cognition or cortical thickness regardless of Abeta status.
+
+ CONCLUSION: Plasma adiponectin can be a potential biomarker for predicting the speed of AD progression in individuals with Abeta (+) MCI. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Peptides). 0 (Adiponectin). 0 (Leptin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, U.S. Gov't, Non-P.H.S.. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs13195-022-01107-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1758-9193&title=Alzheimer%27s+Research+%26+Therapy&atitle=Plasma+adiponectin+levels+predict+cognitive+decline+and+cortical+thinning+in+mild+cognitive+impairment+with+beta-amyloid+pathology.&volume=14&issue=1&spage=165&epage=&date=2022&doi=10.1186%2Fs13195-022-01107-3&pmid=36329496&sid=OVID:medline
+
+<382>
+Unique Identifier
+ 36311488
+Title
+ The Association of Inflammatory Markers, IL-1alpha and TGF-beta, with Dietary Insulin Load and Dietary Insulin Index in Overweight and Obese Women with Healthy and Unhealthy Metabolic Phenotypes: A Cross-Sectional Study.
+Source
+ International Journal of Clinical Practice. 2022:3407320, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Noori S; Mirzababaei A; Shiraseb F; Bagheri R; Clark CCT; Wong A; Suzuki K; Mirzaei K
+Author NameID
+ Noori, Sahar; ORCID: https://orcid.org/0000-0003-3268-1552
+ Mirzababaei, Atieh; ORCID: https://orcid.org/0000-0003-3631-7723
+ Shiraseb, Farideh; ORCID: https://orcid.org/0000-0001-9279-5063
+ Bagheri, Reza; ORCID: https://orcid.org/0000-0002-4280-8636
+ Clark, Cain C T; ORCID: https://orcid.org/0000-0002-6610-4617
+ Wong, Alexei; ORCID: https://orcid.org/0000-0003-2695-8850
+ Suzuki, Katsuhiko; ORCID: https://orcid.org/0000-0002-6572-5809
+ Mirzaei, Khadijeh; ORCID: https://orcid.org/0000-0003-0231-0478
+Authors Full Name
+ Noori, Sahar; Mirzababaei, Atieh; Shiraseb, Farideh; Bagheri, Reza; Clark, Cain C T; Wong, Alexei; Suzuki, Katsuhiko; Mirzaei, Khadijeh.
+Institution
+ Noori, Sahar. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
+ Mirzababaei, Atieh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Shiraseb, Farideh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Bagheri, Reza. Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
+ Clark, Cain C T. Centre for Intelligent Healthcare, Coventry University, Coventry CV1 5FB, UK.
+ Wong, Alexei. Department of Health and Human Performance, Marymount University, Arlington, USA.
+ Suzuki, Katsuhiko. Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+MeSH Subject Headings
+ Female
+ Humans
+ Biomarkers
+ Body Mass Index
+ Cross-Sectional Studies
+ Diet
+ *Insulin
+ Obesity/me [Metabolism]
+ *Overweight
+ Phenotype
+ Transforming Growth Factor beta
+Abstract
+ Context Research has shown IL-1alpha might play a role in the associations between the MH group and DII and DIL. Objective. We evaluated the association of inflammatory markers, IL-1alpha and TGF-beta, with dietary insulin load and index in women with healthy and unhealthy obesity phenotypes. Materials and Methods. 228 obese/overweight women aged 18-48 years were included in this study. Biochemical factors were obtained from blood samples. Body composition, anthropometric measures, and physical activity assessments were performed. Dietary intakes, DII, and DIL were assessed. Results. Significant associations were observed between the MH group and the DII group (OR = 2.142, 95% CI = 1.421, 2.850, and p = 0.040), in which IL-1alpha may play a role. Discussion and Conclusion. Significant associations were observed between the MH group and DII. IL-1alpha might play a role in these associations. Copyright © 2022 Sahar Noori et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 0 (Transforming Growth Factor beta). 0 (IL1A protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1155%2f2022%2f3407320
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Noori&issn=1368-5031&title=International+Journal+of+Clinical+Practice&atitle=The+Association+of+Inflammatory+Markers%2C+IL-1alpha+and+TGF-beta%2C+with+Dietary+Insulin+Load+and+Dietary+Insulin+Index+in+Overweight+and+Obese+Women+with+Healthy+and+Unhealthy+Metabolic+Phenotypes%3A+A+Cross-Sectional+Study.&volume=2022&issue=&spage=3407320&epage=&date=2022&doi=10.1155%2F2022%2F3407320&pmid=36311488&sid=OVID:medline
+
+<383>
+Unique Identifier
+ 36305114
+Title
+ [Serum vitamin K2 level and its association with bone metabolism markers in 1 732 children]. [Chinese]
+Original Title
+ 1 732 K2 .
+Source
+ Zhongguo Dangdai Erke Zazhi. 24(10):1130-1135, 2022 Oct 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ DU CX; Li N
+Authors Full Name
+ DU, Chang-Xiu; Li, Na.
+Institution
+ DU, Chang-Xiu. Department of Child Health Care, Shenyang Children's Hospital, Shenyang 110032, China.
+MeSH Subject Headings
+ Child
+ Humans
+ Infant
+ Biomarkers/me [Metabolism]
+ Collagen Type I/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity
+ Osteocalcin/me [Metabolism]
+ Overweight/co [Complications]
+ *Overweight
+ Peptide Fragments/me [Metabolism]
+ Peptides/me [Metabolism]
+ Procollagen/me [Metabolism]
+ Vitamin K/bl [Blood]
+ *Vitamin K
+ Child, Preschool
+ Adolescent
+ Bone and Bones/me [Metabolism]
+ *Bone and Bones
+Keyword Heading
+ Child
+ Osteocalcin
+ Type I collagen carboxy-terminal peptide
+ Type I procollagen amino-terminal peptide
+ Vitamin K 2
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To study the level of serum vitamin K2 (VitK2) and its association with bone metabolism markers osteocalcin (OC), type I procollagen amino-terminal peptide (PINP), and type I collagen carboxy-terminal peptide (CTX) in children.
+
+ METHODS: A prospective analysis was performed on 1 732 children who underwent routine physical examination from October 2020 to October 2021. The serum levels of VitK2 and 25-hydroxy vitamin D [25(OH)D] were measured. According to age, they were divided into four groups: <1 year, 1-3 years group, >3-6 years group, and >6-14 years. A total of 309 children with 25(OH)D>=50 nmol/L were screened out, and serum levels of OC, PINP, and CTX were measured to investigate the correlation of the serum levels of OC, PINP, and CTX with serum VitK2 levels in different age groups.
+
+ RESULTS: The prevalence rate of serum VitK2 deficiency was 52.31% (906/1 732). The VitK2 deficiency group had higher prevalence rates of overweight/obesity and growth pain (>=3 years of age) than the normal VitK2 group (P<0.05). There were differences in the prevalence rate of serum VitK2 deficiency (P<0.0083) and the serum level of VitK2 (P<0.05) between the 1-3 years group and the >6-14 years group. The <1 year group had a higher serum level of CTX and a lower serum level of PINP than the >3-6 years group and the >6-14 years group (P<0.05). The <1 year group had a lower serum level of OC than the >6-14 years group (P<0.05). Serum VitK2 level was positively correlated with OC level (rs=0.347, P<0.01), and CTX level was negatively correlated with PINP level (rs=-0.317, P<0.01).
+
+ CONCLUSIONS: Serum VitK2 deficiency may be associated with overweight/obesity. Serum VitK2 may affect the level of OC and even bone health.
+Other Abstract
+ Publisher
+ : K2(vitamin K2,VitK2) (osteocalcin,OC) I (type I procollagen amino-terminal peptide,PINP) I (type I collagen carboxy-terminal peptide,CTX) : 2020 10 2021 10 1 732 , VitK2 25 D[25-hydroxyvitamin D,25(OH)D] , <1 1~3 >3~6 >6~14 , VitK2 25(OH)D>=50 nmol/L 309 , OC PINP CTX , VitK2 : VitK2 52.31%(906/1 732) VitK2 / (>=3 ) VitK2 (P<0.05);1~3 >6~14 VitK2 (P<0.0083) VitK2 (P<0.05) <1 CTX >3~6 >6~14 , <1 PINP >3~6 >6~14 (P<0.05);<1 OC >6~14 (P<0.05) VitK2 OC (rs=0.347,P<0.01),CTX PINP (rs=-0.317,P<0.01) : VitK2 / ; VitK2 OC .
+ Language: Chinese
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Collagen Type I). 104982-03-8 (Osteocalcin). 0 (Peptide Fragments). 0 (Peptides). 0 (Procollagen). 12001-79-5 (Vitamin K).
+Publication Type
+ English Abstract. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.7499%2fj.issn.1008-8830.2205090
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=DU&issn=1008-8830&title=Zhongguo+Dangdai+Erke+Zazhi&atitle=1+732+K2+.&volume=24&issue=10&spage=1130&epage=1135&date=2022&doi=10.7499%2Fj.issn.1008-8830.2205090&pmid=36305114&sid=OVID:medline
+
+<384>
+Unique Identifier
+ 36301824
+Title
+ The role of fat distribution and inflammation in the origin of endometrial cancer, study protocol of the ENDOCRINE study.
+Source
+ PLoS ONE [Electronic Resource]. 17(10):e0276516, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van den Bosch AAS; Pijnenborg JMA; Romano A; Haldorsen IS; Werner HMJ
+Author NameID
+ van den Bosch, A A S; ORCID: https://orcid.org/0000-0003-0319-4798
+Authors Full Name
+ van den Bosch, A A S; Pijnenborg, J M A; Romano, A; Haldorsen, I S; Werner, H M J.
+Institution
+ van den Bosch, A A S. Department of Obstetrics and Gynecology, GROW-School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands.
+ Pijnenborg, J M A. Department of Obstetrics & Gynaecology, Radboudumc, Nijmegen, The Netherlands.
+ Romano, A. Department of Obstetrics and Gynecology, GROW-School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands.
+ Haldorsen, I S. Mohn Medical Imaging and Visualization Center, Haukeland University Hospital/University of Bergen, Bergen, Norway.
+ Werner, H M J. Department of Obstetrics and Gynecology, GROW-School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands.
+MeSH Subject Headings
+ Female
+ Humans
+ Adipose Tissue/pa [Pathology]
+ *Adipose Tissue
+ Biomarkers
+ Body Mass Index
+ Endometrial Neoplasms/co [Complications]
+ *Endometrial Neoplasms
+ Hormones
+ Inflammation/pa [Pathology]
+ Intra-Abdominal Fat/pa [Pathology]
+ Obesity/pa [Pathology]
+ Observational Studies as Topic
+ Prospective Studies
+ Multicenter Studies as Topic
+Abstract
+ BACKGROUND: Obesity is a growing problem worldwide, especially in countries with improved socioeconomic circumstances. Also, in the Netherlands the incidence of overweight and obesity is rising. There is increasing evidence on the association between obesity and tumorigenesis. Of all cancer types, endometrial cancer (EC) has the strongest positive correlation with obesity. Obesity is generally defined as a body mass index (BMI) >30, yet does not cover the differences in fat distribution in visceral and subcutaneous compartments. Visceral fat is assumed to be relatively more metabolically active and likely negative prognostic biomarker in non-endometrioid EC. Whereas subcutaneous fat is mainly responsible for oestrogen production through increased aromatase activity.
+
+ OBJECTIVE: The aim of this study is to compare hormone levels and inflammatory markers after bilateral salpingo-oophorectomy (BSO) in obese and non-obese patients. Secondary objectives are to compare the effect of fat distribution and diagnosis (benign vs. EC) on the observed changes in hormone levels and inflammatory markers, and to compare the effect of BSO on menopausal complaints.
+
+ METHODS: Prospective multicentre observational cohort study. A total of 160 patients will be included, of which 80 patients with a normal BMI (18-25 kg/m2) and 80 patients with an obese BMI >32-35 kg/m2. Preoperative abdominal CT will be performed and fasting venous blood samples are obtained for hormone levels and inflammation markers analysis. During surgery, adipose tissue biopsies of subcutaneous and visceral (omental and intestinal epiploic fat) compartments will be collected and stored fresh frozen. In addition a fasting blood draw six weeks after surgery will be obtained. All subjects will fill in two questionnaires before surgery and one after surgery.
+
+ DISCUSSION: We hypothesize that BMI, the type of fat distribution, and possibly the underlying pathology significantly influence in hormone levels, and systemic inflammation changes after BSO. Previous studies have found several clues for a relationship between obesity and endometrial cancer. We expect that our study will contribute to pinpoint the exact differences between 'healthy obesity' and 'unhealthy obesity' and will help to identify patients that are more at risk of developing cancer (or possibly suffer from other related problems such as cardiovascular problems e.g.).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hormones).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1371%2fjournal.pone.0276516
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+den+Bosch&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=The+role+of+fat+distribution+and+inflammation+in+the+origin+of+endometrial+cancer%2C+study+protocol+of+the+ENDOCRINE+study.&volume=17&issue=10&spage=e0276516&epage=&date=2022&doi=10.1371%2Fjournal.pone.0276516&pmid=36301824&sid=OVID:medline
+
+<385>
+Unique Identifier
+ 36300106
+Title
+ TSH-SPP1/TRbeta-TSH positive feedback loop mediates fat deposition of hepatocyte: Crosstalk between thyroid and liver.
+Source
+ Frontiers in Immunology. 13:1009912, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang B; Wen W; Ye S
+Authors Full Name
+ Huang, Bin; Wen, Wenjie; Ye, Shandong.
+Institution
+ Huang, Bin. Department of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.
+ Wen, Wenjie. Department of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.
+ Wen, Wenjie. Division of Life Sciences, University of Science and Technology of China, Hefei, China.
+ Ye, Shandong. Department of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.
+MeSH Subject Headings
+ Animals
+ Mice
+ Biomarkers/me [Metabolism]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Feedback
+ Formaldehyde
+ Hepatocytes/me [Metabolism]
+ Lipids
+ Mice, Inbred C57BL
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/pa [Pathology]
+ Osteopontin/me [Metabolism]
+ Thyroid Gland/me [Metabolism]
+ Thyroid Hormone Receptors beta/ge [Genetics]
+ Thyroid Hormone Receptors beta/me [Metabolism]
+ Thyroid Hormones/me [Metabolism]
+ Thyrotropin
+ Humans
+Keyword Heading
+ M1 macrophage polarization
+ SPP1
+ TSH
+ non-alcoholic fatty liver disease
+ obesity
+ positive feedback crosstalk
+ thyroid function
+ thyroid hormone receptor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aims: We conducted this study with two aims: (1) whether TRbeta could be damaged by NAFLD, thereby represent thyroid hormone resistance-like manifestation and (2) to analyze the potential role of SPP1 in TH signaling pathway on the process of NAFLD. This study is expected to provide a new perspective on the therapeutic mechanism in the pathological course of NAFLD.
+
+ Methods: A total of 166 patients diagnosed with type 2 diabetes mellitus (T2DM) were enrolled in this study. All patients had a BMI above 24 kg/m2 and were stratified into two groups: NAFLD and Non-NAFLD groups. Ages, gender, BMI, duration of diabetes and biochemical markers were obtained from participants' records. We downloaded the dataset GSE48452 from GEO. The Pathview library was used to make the thyroid hormone signaling pathway visualization. The CIBERSORT algorithm was applied to calculate the infiltrated immune cells in obese NAFLD patients. C57BL/6 mice were randomly selected to constitute the normal control (NC) group and were fed a normal chow diet; the rest of the mice were fed a high-fat diet (HFD). After 12 weeks HFD feeding, the mice were sacrificed by cervical dislocation, and blood samples were collected. Mouse livers were also collected; one part of each liver was fixed in 10% formalin for histological analysis, and the other part was snap-frozen for subsequent molecular analyses. To explore the relationship between SPP1, TRbeta and lipid deposition in hepatocytes, HepG2 cells were treated with 50 mu M concentration of PA and/or 20 ng/ml concentration of rh-SPP1 for 48h. In addition, the PC3.1-TRbeta plasmid was constructed for further validation in HepG2 cells. We used THP-1 cells to construct an M1 macrophage model in vitro. We then analyzed THP-1 cells treated with various concentrations of PA or TSH.
+
+ Results: (1) After adjusting for all factors that appeared P value less than 0.1 in the univariate analysis, BMI, TSH, and FT3 were significant independent risk factors of NAFLD (ORs were 1.218, 1.694, and 2.259, respectively); (2) A further analysis with BMI stratification indiacted that both FT3 and TSH had a significant change between individuals with NAFLD and Non-NAFLD in obesity subgroup; however, there was no statistic difference in over-weight group; (3) Bioinformatics analysis of GSE48452 had shown that several key molecular (including TRbeta) of thyroid hormone pathway affected by NAFLD induced transcriptomic changes and the expression levels of SPP1, FABP4 and RPS4Y1 were significantly higher, while the expression levels of PZP and VIL1 were significantly decreased in NAFLD patients(adjusted p < 0.05,
+
+ logFC
+
+ > 1.0). The CIBERSORT algorithm showed increased M0 and M1, decreased M2 macrophage infiltration in NAFLD with comparison to healthy obese group; (4) After 12 weeks of HFD-feeding, the obesity mice had significantly higher serum TSH and In IHC-stained liver sections of obesity group, the intensity of SPP1 had a significantly increased, while TRbeta reduced; (5) In vitro studies have shown SPP1 aggravated lipid deposition in hepatic cells dependent on down-regulating the expression of TRbeta and TSH acts to promote secretion of SPP1 in M1 macrophage cells.
+
+ Conclusions: SPP1 secretion induced by M1 macrophage polarization, which may down-regulates TRbeta in hepatocytes via paracrine manner, on the one hand, the lipid deposition aggravating in liver, on the other hand, a compensatory increase of TSH in serum. The increased TSH can further lead to the following SPP1 secretion of M1 macrophage. The positive feedback crosstalk between thyroid and liver, may be plays an important role in maintaining and amplifying pathological process of NAFLD. Copyright © 2022 Huang, Wen and Ye.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1HG84L3525 (Formaldehyde). 0 (Lipids). 106441-73-0 (Osteopontin). 0 (Spp1 protein, mouse). 0 (Thyroid Hormone Receptors beta). 0 (Thyroid Hormones). 9002-71-5 (Thyrotropin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffimmu.2022.1009912
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=1664-3224&title=Frontiers+in+Immunology&atitle=TSH-SPP1%2FTRbeta-TSH+positive+feedback+loop+mediates+fat+deposition+of+hepatocyte%3A+Crosstalk+between+thyroid+and+liver.&volume=13&issue=&spage=1009912&epage=&date=2022&doi=10.3389%2Ffimmu.2022.1009912&pmid=36300106&sid=OVID:medline
+
+<386>
+Unique Identifier
+ 36299458
+Title
+ Obesity paradox and aging: Visceral Adiposity Index and all-cause mortality in older individuals: A prospective cohort study.
+Source
+ Frontiers in Endocrinology. 13:975209, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang L; Yi Z
+Authors Full Name
+ Wang, Lei; Yi, Zhong.
+Institution
+ Wang, Lei. Department of Cardiology, Aerospace Center Hospital, Beijing, China.
+ Yi, Zhong. Department of Geriatric Medicine, Aerospace Center Hospital, Beijing, China.
+MeSH Subject Headings
+ Aged
+ Humans
+ Female
+ Male
+ *Adiposity
+ Nutrition Surveys
+ Prospective Studies
+ Cohort Studies
+ Obesity, Abdominal/co [Complications]
+ *Obesity, Abdominal
+ Obesity/co [Complications]
+ Biomarkers
+ Aging
+ Lipids
+Keyword Heading
+ aging
+ all-cause mortality
+ obesity paradox
+ older individuals
+ visceral adiposity index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: The relationship between body mass index (BMI) and mortality in older adults diminished. It is necessary to examine other factors that may accurately predict mortality in older adults. The visceral adiposity index (VAI) is an uncomplicated marker specific to the gender that incorporates anthropometric data and lipid profiles. VAI has been proposed as a marker of visceral adipose tissue dysfunction and of the related cardiometabolic risk. The aim of this study was to evaluate the link of VAI with all-cause mortality among the elderly.
+
+ Methods: The present prospective cohort study included data from 1999 to 2014 provided by the National Health and Nutrition Examination Survey (NHANES) in the United States. NHANES participants at or above the age of 65 were included. Data collection was carried out by taking face-to-face interviews, mobile-physical examinations, and lab tests. From the start of the survey to the end of December 2015, mortality-related follow-up statistics are available. The shape of the link between VAI and all-cause mortality was investigated using a restricted cubic spline model. Univariate- and multivariate-adjusted Cox proportional hazard models were estimated for VAI, and the results were presented as regression coefficients and 95% confidence intervals (CI).
+
+ Results: The 82,091 NHANES participants represented 442.2 million non-institutionalized residents of the United States. A total of 11,173 older individuals (representing 23.3 million; aged 73.4 +/- 5.8 years; 56.3% women, 82.7% non-Hispanic Whites, 6.8% non-Hispanic Blacks, and 3.3% Mexican Americans) were included in the study. During the 80-month follow-up period, 4466 fatalities were reported, including 825 deaths from cancer, 867 from heart disease, and 211 from cerebrovascular disease. The restricted cubic spline model demonstrated a robust J-shaped link between VAI and all-cause mortality, revealing a significant decrease in risk within the lower range of VAI, which attained the lowest risk close to 1.7. With VAI greater than 1.7, the risk of mortality increased with the increase of VAI (P for non-linearity = 0.025). In the multivariate-adjusted model, the risk of all-cause mortality was 0.73 (0.56-0.97) and 1.05 (1.01-1.09) in participants with VAI less than 1.7 and VAI greater than or equal to 1.7, respectively.
+
+ Conclusion: This investigation is a population-based cohort study with high sample sizes and a long-term in older individuals follow-up that showed a J-shaped link between VAI levels and all-cause mortality. Understanding the independent roles of VAI in the relationship between BMI and mortality is crucial to understanding the obesity paradox phenomenon. Copyright © 2022 Wang and Yi.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.975209
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Obesity+paradox+and+aging%3A+Visceral+Adiposity+Index+and+all-cause+mortality+in+older+individuals%3A+A+prospective+cohort+study.&volume=13&issue=&spage=975209&epage=&date=2022&doi=10.3389%2Ffendo.2022.975209&pmid=36299458&sid=OVID:medline
+
+<387>
+Unique Identifier
+ 36297122
+Title
+ Higher Adherence to a Mediterranean Diet Is Associated with Improved Insulin Sensitivity and Selected Markers of Inflammation in Individuals Who Are Overweight and Obese without Diabetes.
+Source
+ Nutrients. 14(20), 2022 Oct 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sood S; Feehan J; Itsiopoulos C; Wilson K; Plebanski M; Scott D; Hebert JR; Shivappa N; Mousa A; George ES; Courten B
+Author NameID
+ Sood, Surbhi; ORCID: https://orcid.org/0000-0002-5671-4817
+ Feehan, Jack; ORCID: https://orcid.org/0000-0002-9627-1299
+ Plebanski, Magdalena; ORCID: https://orcid.org/0000-0001-6889-3667
+ Scott, David; ORCID: https://orcid.org/0000-0001-5226-1972
+ Hebert, James R; ORCID: https://orcid.org/0000-0002-0677-2672
+ Mousa, Aya; ORCID: https://orcid.org/0000-0002-7356-4523
+ George, Elena S; ORCID: https://orcid.org/0000-0002-1385-2371
+Authors Full Name
+ Sood, Surbhi; Feehan, Jack; Itsiopoulos, Catherine; Wilson, Kirsty; Plebanski, Magdalena; Scott, David; Hebert, James R; Shivappa, Nitin; Mousa, Aya; George, Elena S; Courten, Barbora de.
+Institution
+ Sood, Surbhi. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, VIC 3216, Australia.
+ Feehan, Jack. Institute for Health and Sport, Victoria University, Footscray, VIC 3011, Australia.
+ Itsiopoulos, Catherine. Department of Medicine, Nursing and Health Sciences, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.
+ Wilson, Kirsty. Department of Medicine, Nursing and Health Sciences, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.
+ Plebanski, Magdalena. Department of Medicine, Nursing and Health Sciences, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.
+ Scott, David. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, VIC 3216, Australia.
+ Scott, David. Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.
+ Hebert, James R. Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
+ Hebert, James R. Department of Nutrition, Connecting Health Innovations LLC, Columbia, SC 29208, USA.
+ Shivappa, Nitin. Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
+ Shivappa, Nitin. Department of Nutrition, Connecting Health Innovations LLC, Columbia, SC 29208, USA.
+ Mousa, Aya. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC 3168, Australia.
+ George, Elena S. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, VIC 3216, Australia.
+ Courten, Barbora de. Department of Medicine, Nursing and Health Sciences, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.
+ Courten, Barbora de. Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.
+MeSH Subject Headings
+ Adult
+ Humans
+ Male
+ Young Adult
+ Adipokines/me [Metabolism]
+ Adiponectin
+ Biomarkers
+ Cholesterol
+ Complement Factor D
+ Cross-Sectional Studies
+ Cytokines
+ *Diabetes Mellitus, Type 2
+ Diet
+ *Diet, Mediterranean
+ Glucose
+ Inflammation
+ *Insulin Resistance
+ Lipids
+ NF-kappa B
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Overweight/co [Complications]
+Keyword Heading
+ diabetes
+ dietary inflammatory index
+ inflammation
+ insulin sensitivity
+ mediterranean diet
+ metabolic disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Insulin resistance (IR) and chronic low-grade inflammation are risk factors for chronic diseases including type 2 diabetes (T2D) and cardiovascular disease. This study aimed to investigate two dietary indices: Mediterranean Diet Score (MDS) and Dietary Inflammatory Index (DII R), and their associations with direct measures of glucose metabolism and adiposity, and biochemical measures including lipids, cytokines and adipokines in overweight/obese adults. This cross-sectional study included 65 participants (males = 63%; age 31.3 +/- 8.5 years). Dietary intake via 3-day food diaries was used to measure adherence to MDS (0-45 points); higher scores indicating adherence. Energy-adjusted DII (E-DII) scores were calculated with higher scores indicating a pro-inflammatory diet. IR was assessed using hyperinsulinemic euglycemic clamps, insulin secretion by intravenous glucose tolerance test, adiposity by dual-energy X-ray absorptiometry, and circulating cytokine and adipokine concentrations by multiplex assays. Higher MDS was associated with greater insulin sensitivity (beta = 0.179; 95%CI: 0.39, 0.318) after adjusting for age, sex and % body fat, and lower NF-kappaB, higher adiponectin and adipsin in unadjusted and adjusted models. Higher E-DII score was associated with increased total cholesterol (beta = 0.364; 95%CI: 0.066, 0.390) and LDL-cholesterol (beta = 0.305; 95%CI: 0.019, 0.287) but not with adiposity, glucose metabolism, cytokines or adipokines. Greater MDS appears to be associated with decreased IR and inflammatory markers in overweight/obese adults.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 97C5T2UQ7J (Cholesterol). EC 3-4-21-46 (Complement Factor D). 0 (Cytokines). IY9XDZ35W2 (Glucose). 0 (Lipids). 0 (NF-kappa B).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14204437
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sood&issn=2072-6643&title=Nutrients&atitle=Higher+Adherence+to+a+Mediterranean+Diet+Is+Associated+with+Improved+Insulin+Sensitivity+and+Selected+Markers+of+Inflammation+in+Individuals+Who+Are+Overweight+and+Obese+without+Diabetes.&volume=14&issue=20&spage=&epage=&date=2022&doi=10.3390%2Fnu14204437&pmid=36297122&sid=OVID:medline
+
+<388>
+Unique Identifier
+ 36295662
+Title
+ Inflammatory Biomarkers as Prognostic Factors of Acute Deep Vein Thrombosis Following the Total Knee Arthroplasty.
+Source
+ Medicina (Kaunas, Lithuania). 58(10), 2022 Oct 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Melinte RM; Arbanasi EM; Blesneac A; Zolog DN; Kaller R; Muresan AV; Arbanasi EM; Melinte IM; Niculescu R; Russu E
+Author NameID
+ Arbanasi, Emil Marian; ORCID: https://orcid.org/0000-0002-1664-8130
+Authors Full Name
+ Melinte, Razvan Marian; Arbanasi, Emil Marian; Blesneac, Adrian; Zolog, Dan Nicolae; Kaller, Reka; Muresan, Adrian Vasile; Arbanasi, Eliza Mihaela; Melinte, Ioana Marta; Niculescu, Raluca; Russu, Eliza.
+Institution
+ Melinte, Razvan Marian. Department of Orthopedics, Regina Maria Health Network, 540098 Targu Mures, Romania.
+ Melinte, Razvan Marian. Department of Orthopedics, Humanitas MedLife Hospital, 400664 Cluj Napoca, Romania.
+ Arbanasi, Emil Marian. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Blesneac, Adrian. Department of Orthopedics, Regina Maria Health Network, 540098 Targu Mures, Romania.
+ Zolog, Dan Nicolae. Department of Orthopedics, Regina Maria Health Network, 540098 Targu Mures, Romania.
+ Kaller, Reka. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Muresan, Adrian Vasile. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Muresan, Adrian Vasile. Department of Surgery, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Arbanasi, Eliza Mihaela. Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Melinte, Ioana Marta. Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Niculescu, Raluca. Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
+ Russu, Eliza. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
+ Russu, Eliza. Department of Surgery, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
+MeSH Subject Headings
+ Humans
+ Adolescent
+ Adult
+ Arthroplasty, Replacement, Knee/ae [Adverse Effects]
+ *Arthroplasty, Replacement, Knee
+ Prognosis
+ Retrospective Studies
+ Biomarkers
+ Venous Thrombosis/di [Diagnosis]
+ Venous Thrombosis/et [Etiology]
+ *Venous Thrombosis
+ Inflammation/et [Etiology]
+ Acute Disease
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+Keyword Heading
+ AISI
+ DVT
+ MLR
+ NLR
+ PLR
+ SII
+ SIRI
+ TKA
+ inflammatory biomarkers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background and objectives: Deep vein thrombosis (DVT) is one of the most serious post-operative complications in the case of total knee arthroplasty (TKA). This study aims to verify the predictive role of inflammatory biomarkers [monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), systemic inflammatory index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI)] in acute DVT following TKA. Materials and methods: The present study was designed as an observational, analytical, retrospective cohort study and included all patients over 18 years of age with surgical indications for TKA, admitted to the Department of Orthopedics, Regina Maria Health Network, Targu Mures, Romania, and the Department of Orthopedics, Humanitas MedLife Hospital, Cluj-Napoca, Romania between January 2017 and July 2022. The primary endpoint was the risk of acute DVT following the TKA, and the secondary endpoint was the length of hospital stay, and the outcomes were stratified for the baseline's optimal MLR, NLR, PLR, SII, SIRI, and AISI cut-off value. Results: DVT patients were associated with higher age (p = 0.01), higher incidence of cardiac disease [arterial hypertension (p = 0.02), atrial fibrillation (p = 0.01)], malignancy (p = 0.005), as well as risk factors [smoking (p = 0.03) and obesity (p = 0.02)]. Multivariate analysis showed a high baseline value for all hematological ratios: MLR (OR: 11.06; p < 0.001), NLR (OR: 10.15; p < 0.001), PLR (OR: 12.31; p < 0.001), SII (OR: 18.87; p < 0.001), SIRI (OR: 10.86; p < 0.001), and AISI (OR: 14.05; p < 0.001) was an independent predictor of DVT after TKA for all recruited patients. Moreover, age above 70 (OR: 2.96; p = 0.007), AH (OR: 2.93; p = 0.02), AF (OR: 2.71; p = 0.01), malignancy (OR: 3.98; p = 0.002), obesity (OR: 2.34; p = 0.04), and tobacco (OR: 2.30; p = 0.04) were all independent predictors of DVT risk. Conclusions : Higher pre-operative hematological ratios MLR, NLR, PLR, SII, SIRI, and AISI values determined before operations strongly predict acute DVT following TKA. Moreover, age over 70, malignancy, cardiovascular disease, and risk factors such as obesity and tobacco were predictive risk factors for acute DVT.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fmedicina58101502
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Melinte&issn=1010-660X&title=Medicina+%28Kaunas%2C+Lithuania%29&atitle=Inflammatory+Biomarkers+as+Prognostic+Factors+of+Acute+Deep+Vein+Thrombosis+Following+the+Total+Knee+Arthroplasty.&volume=58&issue=10&spage=1502&epage=&date=2022&doi=10.3390%2Fmedicina58101502&pmid=36295662&sid=OVID:medline
+
+<389>
+Unique Identifier
+ 36258233
+Title
+ Effects of a high-fat meal on inflammatory and endothelial injury biomarkers in accordance with adiposity status: a cross-sectional study.
+Source
+ Nutrition Journal. 21(1):65, 2022 10 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Souza MDGC; Maranhao PA; Panazzolo DG; Nogueira Neto JF; Bouskela E; Kraemer-Aguiar LG
+Authors Full Name
+ de Souza, Maria das Gracas Coelho; Maranhao, Priscila Alves; Panazzolo, Diogo Guarnieri; Nogueira Neto, Jose Firmino; Bouskela, Eliete; Kraemer-Aguiar, Luiz Guilherme.
+Institution
+ de Souza, Maria das Gracas Coelho. Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil.
+ Maranhao, Priscila Alves. Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil.
+ Maranhao, Priscila Alves. Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, 4200-319, Porto, Portugal.
+ Panazzolo, Diogo Guarnieri. Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil.
+ Nogueira Neto, Jose Firmino. Lipids Laboratory (Lablip), State University of Rio de Janeiro (UERJ), Policlinica Piquet Carneiro, 20550-003, Rio de Janeiro, RJ, Brazil.
+ Bouskela, Eliete. Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil.
+ Bouskela, Eliete. Obesity Unit, Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de Janeiro (UERJ), 20551-030, Rio de Janeiro, RJ, Brazil.
+ Kraemer-Aguiar, Luiz Guilherme. Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil. lgkraemeraguiar@gmail.com.
+ Kraemer-Aguiar, Luiz Guilherme. Department of Internal Medicine, Faculty of Medical Sciences, State University of Rio de Janeiro (UERJ), 20551-170, Rio de Janeiro, RJ, Brazil. lgkraemeraguiar@gmail.com.
+ Kraemer-Aguiar, Luiz Guilherme. Obesity Unit, Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de Janeiro (UERJ), 20551-030, Rio de Janeiro, RJ, Brazil. lgkraemeraguiar@gmail.com.
+MeSH Subject Headings
+ Female
+ Humans
+ Adipokines
+ Adiponectin
+ *Adiposity
+ Biomarkers
+ Cross-Sectional Studies
+ E-Selectin/me [Metabolism]
+ Endothelium, Vascular
+ Fatty Acids, Nonesterified
+ Intercellular Adhesion Molecule-1/me [Metabolism]
+ Intercellular Adhesion Molecule-1/pd [Pharmacology]
+ Interleukin-6
+ *Leptin
+ Obesity
+ Plasminogen Activator Inhibitor 1/me [Metabolism]
+ Plasminogen Activator Inhibitor 1/pd [Pharmacology]
+ Tumor Necrosis Factor-alpha
+ Vascular Cell Adhesion Molecule-1/me [Metabolism]
+ Vascular Cell Adhesion Molecule-1/pd [Pharmacology]
+Keyword Heading
+ Endothelium
+ High fat meal
+ Inflammation
+ Obesity
+ Postprandial period
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: It is known that consuming a high-fat meal (HFM) induces microvascular dysfunction (MD) in eutrophic women and aggravates it in those with obesity. Our purpose was to investigate if the MD observed after a single HFM intake is caused by endothelial damage or increased inflammatory state, both determined by blood biomarkers.
+
+ METHODS: Nineteen women with obesity (BMI 30-34.9 kg/m2) and 18 eutrophic ones (BMI 20.0-24.9 kg/m2) were enrolled into two groups: Obese (OBG) and Control (CG), respectively. Blood samples were collected at five-time points: before (fasting state) and 30, 60, 120, and 180 min after HFM intake to determine levels of adipokines (adiponectin, leptin), non-esterified fatty acid (NEFA), inflammatory [tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6)] and endothelium damage [soluble E-selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor-1 (PAI-1)] biomarkers.
+
+ RESULTS: Levels of soluble E-selectin, leptin, and PAI-1 were higher in OBG at all-time points (P < 0.05) compared to CG. In the fasting state, OBG had higher levels of NEFA compared to CG (P < 0.05). In intra-group analysis, no significant change in the levels of circulating inflammatory and endothelial injury biomarkers was observed after HFM intake, independently of the group.
+
+ CONCLUSION: Our findings suggest that women with obesity have an increased pro-inflammatory state and more significant endothelial injury compared to eutrophic ones. However, the consumption of a HFM was not sufficient to change circulating levels of inflammatory and endothelial injury biomarkers in either group.
+
+ REGISTRATION NUMBER FOR CLINICAL TRIALS: NCT01692327. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (E-Selectin). 0 (Fatty Acids, Nonesterified). 126547-89-5 (Intercellular Adhesion Molecule-1). 0 (Interleukin-6). 0 (Leptin). 0 (Plasminogen Activator Inhibitor 1). 0 (Tumor Necrosis Factor-alpha). 0 (Vascular Cell Adhesion Molecule-1).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12937-022-00819-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Souza&issn=1475-2891&title=Nutrition+Journal&atitle=Effects+of+a+high-fat+meal+on+inflammatory+and+endothelial+injury+biomarkers+in+accordance+with+adiposity+status%3A+a+cross-sectional+study.&volume=21&issue=1&spage=65&epage=&date=2022&doi=10.1186%2Fs12937-022-00819-4&pmid=36258233&sid=OVID:medline
+
+<390>
+Unique Identifier
+ 36253014
+Title
+ Metabolomic markers of glucose regulation after a lifestyle intervention in prediabetes.
+Source
+ BMJ Open Diabetes Research & Care. 10(5), 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sevilla-Gonzalez MDR; Manning AK; Westerman KE; Aguilar-Salinas CA; Deik A; Clish CB
+Author NameID
+ Sevilla-Gonzalez, Magdalena Del Rocio; ORCID: https://orcid.org/0000-0001-6135-9998
+ Manning, Alisa K; ORCID: https://orcid.org/0000-0003-0247-902X
+ Westerman, Kenneth E; ORCID: https://orcid.org/0000-0001-7619-1868
+ Aguilar-Salinas, Carlos Alberto; ORCID: https://orcid.org/0000-0001-8517-0241
+ Deik, Amy; ORCID: https://orcid.org/0000-0002-9687-0953
+ Clish, Clary B; ORCID: https://orcid.org/0000-0001-8259-9245
+Authors Full Name
+ Sevilla-Gonzalez, Magdalena Del Rocio; Manning, Alisa K; Westerman, Kenneth E; Aguilar-Salinas, Carlos Alberto; Deik, Amy; Clish, Clary B.
+Institution
+ Sevilla-Gonzalez, Magdalena Del Rocio. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA msevillagonzalez@mgh.harvard.edu.
+ Sevilla-Gonzalez, Magdalena Del Rocio. Department of Medicine, Harvard Medical School, Boston, MA, USA.
+ Sevilla-Gonzalez, Magdalena Del Rocio. Metabolism Program, The Broad Insitute of MIT and Harvard, Cambridge, MA, USA.
+ Sevilla-Gonzalez, Magdalena Del Rocio. Unidad de Investigacion en Enfermedades Metabolicas, Insituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico City, Mexico.
+ Manning, Alisa K. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
+ Manning, Alisa K. Department of Medicine, Harvard Medical School, Boston, MA, USA.
+ Manning, Alisa K. Metabolism Program, The Broad Insitute of MIT and Harvard, Cambridge, MA, USA.
+ Westerman, Kenneth E. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
+ Westerman, Kenneth E. Department of Medicine, Harvard Medical School, Boston, MA, USA.
+ Westerman, Kenneth E. Metabolism Program, The Broad Insitute of MIT and Harvard, Cambridge, MA, USA.
+ Aguilar-Salinas, Carlos Alberto. Unidad de Investigacion en Enfermedades Metabolicas, Insituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico City, Mexico.
+ Deik, Amy. Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
+ Clish, Clary B. Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
+MeSH Subject Headings
+ Acetylgalactosamine
+ Biomarkers
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ *Diabetes Mellitus, Type 2
+ Diet, Reducing
+ Dietary Proteins/an [Analysis]
+ Glucose
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Metabolomics
+ Obesity/co [Complications]
+ *Prediabetic State
+ Putrescine
+ Taurine
+ Weight Loss
+Keyword Heading
+ biomarkers
+ life style
+ prediabetic state
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Disentangling the specific factors that regulate glycemia from prediabetes to normoglycemia could improve type 2 diabetes prevention strategies. Metabolomics provides substantial insights into the biological understanding of environmental factors such as diet. This study aimed to identify metabolomic markers of regression to normoglycemia in the context of a lifestyle intervention (LSI) in individuals with prediabetes.
+
+ RESEARCH DESIGN AND METHODS: We conducted a single-arm intervention study with 24 weeks of follow-up. Eligible study participants had at least one prediabetes criteria according to the American Diabetes Association guidelines, and body mass index between 25 and 45 kg/m2. LSI refers to a hypocaloric diet and >150 min of physical activity per week. Regression to normoglycemia (RNGR) was defined as achieving hemoglobin A1c (HbA1c) <5.5% in the final visit. Baseline and postintervention plasma metabolomic profiles were measured using liquid chromatography-tandem mass spectrometry. To select metabolites associated with RNGR, we conducted the least absolute shrinkage and selection operator-penalized regressions.
+
+ RESULTS: The final sample was composed of 82 study participants. Changes in three metabolites were significantly associated with regression to normoglycemia; N-acetyl-D-galactosamine (OR=0.54; 95% CI 0.32 to 0.82), putrescine (OR=0.90, 95% CI 0.81 to 0.98), and 7-methylguanine (OR=1.06; 95% CI 1.02 to 1.17), independent of HbA1c and weight loss. In addition, metabolomic perturbations due to LSI displayed enrichment of taurine and hypotaurine metabolism pathway (p=0.03) compatible with biomarkers of protein consumption, lower red meat and animal fats and higher seafood and vegetables.
+
+ CONCLUSIONS: Evidence from this study suggests that specific metabolomic markers have an influence on glucose regulation in individuals with prediabetes after 24 weeks of LSI independently of other treatment effects such as weight loss. Copyright © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Proteins). 0 (Glycated Hemoglobin A). 1EQV5MLY3D (Taurine). IY9XDZ35W2 (Glucose). KM15WK8O5T (Acetylgalactosamine). V10TVZ52E4 (Putrescine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1136%2fbmjdrc-2022-003010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sevilla-Gonzalez&issn=2052-4897&title=BMJ+Open+Diabetes+Research+%26+Care&atitle=Metabolomic+markers+of+glucose+regulation+after+a+lifestyle+intervention+in+prediabetes.&volume=10&issue=5&spage=&epage=&date=2022&doi=10.1136%2Fbmjdrc-2022-003010&pmid=36253014&sid=OVID:medline
+
+<391>
+Unique Identifier
+ 36235811
+Title
+ The Influence of Diet and Physical Activity on Oxidative Stress in Romanian Females with Osteoarthritis.
+Source
+ Nutrients. 14(19), 2022 Oct 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nasui BA; Talaba P; Nasui GA; Sirbu DM; Borda IM; Pop AL; Ciortea VM; Irsay L; Purcar-Popescu AI; Cinteza D; Iliescu MG; Popa FL; Suciu SM; Ungur RA
+Author NameID
+ Nasui, Bogdana Adriana; ORCID: https://orcid.org/0000-0001-5682-0225
+ Ciortea, Viorela Mihaela; ORCID: https://orcid.org/0000-0001-6402-6443
+ Iliescu, Madalina Gabriela; ORCID: https://orcid.org/0000-0002-8573-3160
+ Suciu, Soimita Mihaela; ORCID: https://orcid.org/0000-0003-2208-5132
+ Ungur, Rodica Ana; ORCID: https://orcid.org/0000-0001-8095-8937
+Authors Full Name
+ Nasui, Bogdana Adriana; Talaba, Patricia; Nasui, Gabriel Adrian; Sirbu, Dana Manuela; Borda, Ileana Monica; Pop, Anca Lucia; Ciortea, Viorela Mihaela; Irsay, Laszlo; Purcar-Popescu, Anca Ileana; Cinteza, Delia; Iliescu, Madalina Gabriela; Popa, Florina Ligia; Suciu, Soimita Mihaela; Ungur, Rodica Ana.
+Institution
+ Nasui, Bogdana Adriana. Department of Community Health, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Pasteur Street, No.4, 400349 Cluj-Napoca, Romania.
+ Talaba, Patricia. Department of Community Health, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Pasteur Street, No.4, 400349 Cluj-Napoca, Romania.
+ Nasui, Gabriel Adrian. Faculty of Law, "Dimitrie Cantemir" University, 60 Teodor Mihali Street, 400591 Cluj-Napoca, Romania.
+ Sirbu, Dana Manuela. Department of Community Health, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Pasteur Street, No.4, 400349 Cluj-Napoca, Romania.
+ Borda, Ileana Monica. Department of Medical Specialties, Faculty of Medicine, "Iuliu-Hatieganu" University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
+ Pop, Anca Lucia. Department of Clinical Laboratory, Food Safety, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania.
+ Ciortea, Viorela Mihaela. Department of Medical Specialties, Faculty of Medicine, "Iuliu-Hatieganu" University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
+ Irsay, Laszlo. Department of Medical Specialties, Faculty of Medicine, "Iuliu-Hatieganu" University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
+ Purcar-Popescu, Anca Ileana. Department of Rehabilitation, Rehabilitation Clinical Hospital, 46-60 Viilor Street, 400066 Cluj-Napoca, Romania.
+ Cinteza, Delia. 9th Department-Physical Medicine and Rehabilitation, "Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania.
+ Iliescu, Madalina Gabriela. Department of Rehabilitation, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania.
+ Popa, Florina Ligia. Physical Medicine and Rehabilitation Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu, Victoriei Blvd., 550024 Sibiu, Romania.
+ Popa, Florina Ligia. Academic Emergency Hospital of Sibiu, Coposu Blvd., 550245 Sibiu, Romania.
+ Suciu, Soimita Mihaela. Department of Physiology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
+ Ungur, Rodica Ana. Department of Medical Specialties, Faculty of Medicine, "Iuliu-Hatieganu" University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
+MeSH Subject Headings
+ Adult
+ Antioxidants/me [Metabolism]
+ *Antioxidants
+ Biomarkers
+ Cross-Sectional Studies
+ Diet/ae [Adverse Effects]
+ Exercise
+ Female
+ Fruit/me [Metabolism]
+ Glutathione Disulfide
+ Humans
+ Obesity/ep [Epidemiology]
+ Obesity/et [Etiology]
+ Osteoarthritis/co [Complications]
+ Osteoarthritis/ep [Epidemiology]
+ *Osteoarthritis
+ Oxidative Stress
+ Romania/ep [Epidemiology]
+ Vegetables/me [Metabolism]
+Keyword Heading
+ Romanian females
+ body mass index
+ diet
+ osteoarthritis
+ oxidative status
+ physical activity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Osteoarthritis (OA) is the most prevalent chronic joint disease, increases in prevalence with age, and affects most individuals over 65. The present study aimed to assess the oxidative status in relation to diet and physical activity in patients with OA. We used a cross-sectional study applied to 98 females with OA. Blood samples were collected to determine oxidative stress markers: malonyl dialdehyde (MDA), reduced glutathione (GSH), oxidized glutathione (GSSG), and GSH/GSSG. Diet was estimated with a standardized food frequency questionnaire. We used the International Physical Activity Questionnaire (IPAQ) to assess the females' physical activity. Multiple regression analyses were executed to determine the association between the oxidative markers and the intake of vegetables and fruit. The study showed that most patients were overweight or obese (88.8%). The level of physical activity was above the recommended level for adults, mainly based on household activities. The intake of vegetables and fruit was low. The MDA marker was inversely, statistically significantly associated with the consumption of vegetables (p < 0.05). Public health policies must address modifiable risk factors to reduce energy intake and obesity and increase the intake of vegetables and fruit. Higher consumption of vegetables and fruit may provide natural antioxidants that can balance oxidative compounds.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). ULW86O013H (Glutathione Disulfide).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14194159
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nasui&issn=2072-6643&title=Nutrients&atitle=The+Influence+of+Diet+and+Physical+Activity+on+Oxidative+Stress+in+Romanian+Females+with+Osteoarthritis.&volume=14&issue=19&spage=&epage=&date=2022&doi=10.3390%2Fnu14194159&pmid=36235811&sid=OVID:medline
+
+<392>
+Unique Identifier
+ 36235799
+Title
+ Does the Ketogenic Diet Improve the Quality of Ovarian Function in Obese Women?.
+Source
+ Nutrients. 14(19), 2022 Oct 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Magagnini MC; Condorelli RA; Cimino L; Cannarella R; Aversa A; Calogero AE; La Vignera S
+Author NameID
+ Condorelli, Rosita A; ORCID: https://orcid.org/0000-0002-5217-9343
+ Cannarella, Rossella; ORCID: https://orcid.org/0000-0003-4599-8487
+ Aversa, Antonio; ORCID: https://orcid.org/0000-0002-2989-2618
+ Calogero, Aldo E; ORCID: https://orcid.org/0000-0001-6950-335X
+ La Vignera, Sandro; ORCID: https://orcid.org/0000-0002-7113-2372
+Authors Full Name
+ Magagnini, Maria Cristina; Condorelli, Rosita A; Cimino, Laura; Cannarella, Rossella; Aversa, Antonio; Calogero, Aldo E; La Vignera, Sandro.
+Institution
+ Magagnini, Maria Cristina. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Condorelli, Rosita A. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Cimino, Laura. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Cannarella, Rossella. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Aversa, Antonio. Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
+ Calogero, Aldo E. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ La Vignera, Sandro. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+MeSH Subject Headings
+ Adult
+ Anti-Mullerian Hormone
+ Biomarkers
+ *Diabetes Mellitus, Type 2
+ *Diet, Ketogenic
+ Female
+ Humans
+ Obesity
+ *Polycystic Ovary Syndrome
+ Progesterone
+ Young Adult
+Keyword Heading
+ AMH
+ SHBG
+ ketogenic diet
+ obesity
+ ovarian function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, the prevalence of which ranges from 8 to 13%. It is characterized by metabolic, reproductive, and psychological alterations. PCOS prevalence is related to body mass index (BMI). Women with BMI < 25 kg/m2 have a prevalence of 4.3%, whereas women with BMI > 30 kg/m2 have a prevalence of 14%. Moreover, women with PCOS have a risk of type 2 diabetes mellitus (T2DM) two-fold higher than controls, independently of BMI. Both PCOS and T2DM are also consequences of lower serum sex-hormone-binding globulin (SHBG) levels, which is currently considered a biomarker of metabolic disorders, in particular T2DM. Aim: To evaluate the effect of the very-low-calorie ketogenic diet (VLCKD) on markers suggested to be predictive of metabolic and ovulatory dysfunction. These comprehend SHBG, anti-Mullerian hormone (AMH), and progesterone levels on day 21 of the menstrual cycle in a cohort of obese non-diabetic women with PCOS and regular menses. Methods: Twenty-five patients (mean age 25.4 +/- 3.44 years) with obesity and PCOS underwent VLCKD for 12 weeks. Each of them underwent measurements of anthropometric parameters (body weight, height, and waist circumference) and blood testing to evaluate serum levels of SHBG, AMH, and progesterone before and after 12 weeks of VLCKD. Results: At enrollment, all patients had high BMI, WC, and AMH, whereas SHBG and progesterone levels were low. After VLCKD, the patients showed a significant reduction in BMI, WC, and HOMA index. In particular, 76% of patients (19/25) switched from obesity to overweight, and the HOMA index normalized, reaching values lower than 2.5 in 96% (24/25) of patients. In addition, serum AMH levels significantly decreased, and progesterone and SHBG significantly increased after VLCKD. Conclusions : This is the first study documenting the effects of VLCKD on ovarian reserve and luteal function in women with PCOS. VLCKD could be used to improve metabolic and ovulatory dysfunction in women with PCOS. Further studies are needed to understand the reasons for the AMH reduction.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 4G7DS2Q64Y (Progesterone). 80497-65-0 (Anti-Mullerian Hormone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14194147
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Magagnini&issn=2072-6643&title=Nutrients&atitle=Does+the+Ketogenic+Diet+Improve+the+Quality+of+Ovarian+Function+in+Obese+Women%3F.&volume=14&issue=19&spage=&epage=&date=2022&doi=10.3390%2Fnu14194147&pmid=36235799&sid=OVID:medline
+
+<393>
+Unique Identifier
+ 36232772
+Title
+ Investigation of Transcriptome Patterns in Endometrial Cancers from Obese and Lean Women.
+Source
+ International Journal of Molecular Sciences. 23(19), 2022 Sep 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Takenaka K; Curry-Hyde A; Olzomer EM; Farrell R; Byrne FL; Janitz M
+Author NameID
+ Olzomer, Ellen M; ORCID: https://orcid.org/0000-0002-5823-0736
+ Byrne, Frances L; ORCID: https://orcid.org/0000-0002-8897-8438
+ Janitz, Michael; ORCID: https://orcid.org/0000-0002-4878-0259
+Authors Full Name
+ Takenaka, Konii; Curry-Hyde, Ashton; Olzomer, Ellen M; Farrell, Rhonda; Byrne, Frances L; Janitz, Michael.
+Institution
+ Takenaka, Konii. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
+ Curry-Hyde, Ashton. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
+ Olzomer, Ellen M. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
+ Farrell, Rhonda. Chris O'Brien Lifehouse, Camperdown, NSW 2050, Australia.
+ Byrne, Frances L. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
+ Janitz, Michael. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Endometrial Neoplasms/ge [Genetics]
+ Endometrial Neoplasms/me [Metabolism]
+ *Endometrial Neoplasms
+ Female
+ Humans
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ *Obesity
+ RNA, Long Noncoding/ge [Genetics]
+ *RNA, Long Noncoding
+ Thinness/ge [Genetics]
+ Thinness/me [Metabolism]
+ *Thinness
+ *Transcriptome
+Keyword Heading
+ RNA-seq
+ endometrial cancer
+ gene expression
+ molecular signatures
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Endometrial cancer is the most common gynaecological malignancy in developed countries. One of the largest risk factors for endometrial cancer is obesity. The aim of this study was to determine whether there are differences in the transcriptome of endometrial cancers from obese vs. lean women. Here we investigate the transcriptome of endometrial cancer between obese and lean postmenopausal women using rRNA-depleted RNA-Seq data from endometrial cancer tissues and matched adjacent non-cancerous endometrial tissues. Differential expression analysis identified 12,484 genes (6370 up-regulated and 6114 down-regulated) in endometrial cancer tissues from obese women, and 6219 genes (3196 up-regulated and 3023 down-regulated) in endometrial cancer tissues from lean women (adjusted p-value < 0.1). A gene ontology enrichment analysis revealed that the top 1000 up-regulated genes (by adjusted p-value) were enriched for growth and proliferation pathways while the top 1000 down-regulated genes were enriched for cytoskeleton restructure networks in both obese and lean endometrial cancer tissues. In this study, we also show perturbations in the expression of protein coding genes (HIST1H2BL, HIST1H3F, HIST1H2BH, HIST1H1B, TTK, PTCHD1, ASPN, PRELP, and CDH13) and the lncRNA MBNL1-AS1 in endometrial cancer tissues. Overall, this study has identified gene expression changes that are similar and also unique to endometrial cancers from obese vs. lean women. Furthermore, some of these genes may serve as prognostic biomarkers or, possibly, therapeutic targets for endometrial cancer.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Long Noncoding).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms231911471
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Takenaka&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Investigation+of+Transcriptome+Patterns+in+Endometrial+Cancers+from+Obese+and+Lean+Women.&volume=23&issue=19&spage=11471&epage=&date=2022&doi=10.3390%2Fijms231911471&pmid=36232772&sid=OVID:medline
+
+<394>
+Unique Identifier
+ 36231972
+Title
+ Effect of Sprint Interval Training on Cardiometabolic Biomarkers and Adipokine Levels in Adolescent Boys with Obesity.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 19(19), 2022 10 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Salus M; Tillmann V; Remmel L; Unt E; Maestu E; Parm U; Magi A; Tali M; Jurimae J
+Author NameID
+ Salus, Marit; ORCID: https://orcid.org/0000-0003-1425-6990
+ Tillmann, Vallo; ORCID: https://orcid.org/0000-0002-5279-4493
+ Maestu, Evelin; ORCID: https://orcid.org/0000-0002-2939-9890
+ Jurimae, Jaak; ORCID: https://orcid.org/0000-0003-4819-5241
+Authors Full Name
+ Salus, Marit; Tillmann, Vallo; Remmel, Liina; Unt, Eve; Maestu, Evelin; Parm, Ulle; Magi, Agnes; Tali, Maie; Jurimae, Jaak.
+Institution
+ Salus, Marit. Institute of Sports Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Ujula 4, 51008 Tartu, Estonia.
+ Salus, Marit. Department of Physiotherapy and Environmental Health, Tartu Health Care College, Nooruse 5, 50411 Tartu, Estonia.
+ Tillmann, Vallo. Department of Pediatrics, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Lunini 6, 50406 Tartu, Estonia.
+ Tillmann, Vallo. Children's Clinic of Tartu University Hospital, Lunini 6, 50406 Tartu, Estonia.
+ Remmel, Liina. Institute of Sports Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Ujula 4, 51008 Tartu, Estonia.
+ Unt, Eve. Department of Sports Medicine and Rehabilitation, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Puusepa 8, 50406 Tartu, Estonia.
+ Unt, Eve. Sports Medicine and Rehabilitation Clinic, Tartu University Hospital, Puusepa 8, 50406 Tartu, Estonia.
+ Maestu, Evelin. Institute of Sports Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Ujula 4, 51008 Tartu, Estonia.
+ Parm, Ulle. Department of Physiotherapy and Environmental Health, Tartu Health Care College, Nooruse 5, 50411 Tartu, Estonia.
+ Magi, Agnes. Sports Medicine and Rehabilitation Clinic, Tartu University Hospital, Puusepa 8, 50406 Tartu, Estonia.
+ Tali, Maie. Department of Sports Medicine and Rehabilitation, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Puusepa 8, 50406 Tartu, Estonia.
+ Tali, Maie. Sports Medicine and Rehabilitation Clinic, Tartu University Hospital, Puusepa 8, 50406 Tartu, Estonia.
+ Jurimae, Jaak. Institute of Sports Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Ujula 4, 51008 Tartu, Estonia.
+MeSH Subject Headings
+ Adipokines
+ Adiponectin
+ Adolescent
+ Biomarkers
+ *Cardiovascular Diseases
+ Glucose
+ *High-Intensity Interval Training
+ Humans
+ Insulin
+ Leptin
+ Male
+ *Metabolic Syndrome
+ Obesity
+ Triglycerides
+Keyword Heading
+ adipokines
+ adolescent health
+ metabolic syndrome risk score
+ pediatric obesity
+ sprint interval training
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study investigated the effect of supervised sprint interval training (SIT) on different cardiometabolic risk factors and adipokines in adolescent boys with obesity. Thirty-seven boys were allocated to either a SIT group (13.1 +/- 0.3 years; body mass index [BMI]: 30.3 +/- 0.9 kg.m-2) or a control group (CONT) (13.7 +/- 0.4 years; BMI: 32.6 +/- 1.6 kg.m-2). The SIT group performed 4-6 x 30 s all-out cycling sprints, interspersed with 4 min rest, for 3 sessions/week, during a 12-week period, while the non-exercising CONT group maintained a habitual lifestyle. Anthropometric measurements, triglycerides, fasting insulin and glucose, total cholesterol (TC), high- (HDLc) and low-density (LDLc) cholesterol, leptin and adiponectin in blood, cardiorespiratory fitness (CRF), and a metabolic syndrome severity risk score (MSSS) were calculated before and after the 12-week period. Compared to baseline values, a significant reduction in MSSS was seen in the SIT group after intervention. LDLc showed favorable changes in SIT compared to CONT (-0.06 +/- 0.1 vs. 0.19 +/- 0.01 mmol.L-1; p = 0.025). Additionally, CRF increased in the SIT group compared to the CONT group (5.2 +/- 1.1 vs. -2.1 +/- 1.1 mL.min-1.kg-1, p < 0.001). Moreover, a 12-week all-out SIT training effectively improves cardiometabolic health in adolescent boys with obesity.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (Insulin). 0 (Leptin). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijerph191912672
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Salus&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Effect+of+Sprint+Interval+Training+on+Cardiometabolic+Biomarkers+and+Adipokine+Levels+in+Adolescent+Boys+with+Obesity.&volume=19&issue=19&spage=&epage=&date=2022&doi=10.3390%2Fijerph191912672&pmid=36231972&sid=OVID:medline
+
+<395>
+Unique Identifier
+ 36228249
+Title
+ Importance of epicardial adipose tissue as a predictor of heart failure with preserved ejection fraction.
+Source
+ Revista Da Associacao Medica Brasileira. 68(9):1178-1184, 2022 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ates K; Demir M
+Author NameID
+ Ates, Kenan; ORCID: http://orcid.org/0000-0001-7825-0198
+ Demir, Muhammed; ORCID: http://orcid.org/0000-0002-9049-7123
+Authors Full Name
+ Ates, Kenan; Demir, Muhammed.
+Institution
+ Ates, Kenan. Baglar Private Hospital, Department of Cardiology - Diyarbakir, Turkey.
+ Demir, Muhammed. Dicle University, School of Medicine, Department of Cardiology - Diyarbakir, Turkey.
+MeSH Subject Headings
+ Adipose Tissue/dg [Diagnostic Imaging]
+ Biomarkers
+ Heart Failure/dg [Diagnostic Imaging]
+ *Heart Failure
+ Humans
+ Obesity/co [Complications]
+ Stroke Volume/ph [Physiology]
+Abstract
+ OBJECTIVE: Epicardial adipose tissue is a special form of visceral fat surrounding the heart. It is associated with cardiac and metabolic diseases. Epicardial adipose tissue is associated with risk factors for heart failure with preserved ejection fraction, such as obesity, metabolic syndrome, hypertension, and diabetes. In this study, we examined the importance of Epicardial adipose tissue as a predictor of heart failure with preserved ejection fraction.
+
+ METHODS: Patients who were admitted to the Dicle University Medicine Faculty Heart Hospital between November 2013 and August 2014 were recruited for the study. The heart failure group consisted of 30 patients who were admitted to the cardiac intensive care unit, and the control group consisted of 30 patients who were admitted to cardiology polyclinics. We care about patients' demographic and clinical features to be similar. Heart failure was diagnosed according to the European Cardiology Society 2012 heart failure guidelines. Epicardial adipose tissue was measured with a transthoracic parasternal long axis with an echocardiography device (GE Vivid S6). We compared the Epicardial adipose tissue measurements between the two groups.
+
+ RESULTS: Epicardial adipose tissue was higher in patients with heart failure with preserved ejection fraction than in the control group (9.21+/-0.82 and 7.13+/-1.39 mm, respectively; p<0.001). Echocardiographic findings associated with left ventricular hypertrophy were intact ventricular septum (13.03+/-0.57 and 12.11+/-2.22 mm, respectively; p=0.013) and left ventricular mass index (131.13+/-18.00 and 117.90+/-20.30 g/m2, respectively; p=0.010). Findings associated with left ventricular diastolic dysfunction were as follows: left atrial volume index (60.71+/-21.53 and 44.92+/-9.93 mL/m2, respectively; p<0.001) and E/e (13.87+/-3.88 and 10.12+/-2.44, respectively; p<0.001) were higher in patients with heart failure with preserved ejection fraction than in the control group. Body mass index was not a significant indicator of obesity (p=0.097), but waist circumference was a significant indicator of visceral obesity (p<0.001). Logistic regression analyses indicated that Epicardial adipose tissue, age, left atrial volume index, left ventricular mass index, waist circumference, and E/e were significant in the Heart failure group; Epicardial adipose tissue was significant (p=0.012), and waist circumference significance was borderline (p=0.045).
+
+ CONCLUSIONS: Epicardial adipose tissue was higher in patients with HF than in the control group, and Epicardial adipose tissue was a predictor of heart failure with preserved ejection fraction. In patients with heart failure with preserved ejection fraction, increased Epicardial adipose tissue means that Epicardial adipose tissue can be used as a biomarker of inflammation in the pathophysiology of heart failure with preserved ejection fraction.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1590%2f1806-9282.20220069
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ates&issn=0104-4230&title=Revista+Da+Associacao+Medica+Brasileira&atitle=Importance+of+epicardial+adipose+tissue+as+a+predictor+of+heart+failure+with+preserved+ejection+fraction.&volume=68&issue=9&spage=1178&epage=1184&date=2022&doi=10.1590%2F1806-9282.20220069&pmid=36228249&sid=OVID:medline
+
+<396>
+Unique Identifier
+ 36227107
+Title
+ Altered Gut Microbial Profile Accompanied by Abnormal Fatty Acid Metabolism Activity Exacerbates Endometrial Cancer Progression.
+Source
+ Microbiology Spectrum. 10(6):e0261222, 2022 12 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhao SS; Chen L; Yang J; Wu ZH; Wang XY; Zhang Q; Liu WJ; Liu HX
+Author NameID
+ Liu, Hui-Xin; ORCID: https://orcid.org/0000-0002-8981-9981
+Authors Full Name
+ Zhao, Shan-Shan; Chen, Lei; Yang, Jing; Wu, Zhen-Hua; Wang, Xiao-Yu; Zhang, Qi; Liu, Wen-Jie; Liu, Hui-Xin.
+Institution
+ Zhao, Shan-Shan. Health Sciences Institute, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Zhao, Shan-Shan. School of Life Sciences, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Zhao, Shan-Shan. Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Zhao, Shan-Shan. Department of Gynecology, Cancer Hospital of China Medical Universitygrid.254145.3, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning Province, People's Republic of China.
+ Chen, Lei. Health Sciences Institute, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Chen, Lei. School of Life Sciences, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Chen, Lei. Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Yang, Jing. Health Sciences Institute, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Yang, Jing. School of Life Sciences, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Yang, Jing. Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Wu, Zhen-Hua. Health Sciences Institute, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Wu, Zhen-Hua. School of Life Sciences, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Wu, Zhen-Hua. Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Wang, Xiao-Yu. Health Sciences Institute, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Wang, Xiao-Yu. School of Life Sciences, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Wang, Xiao-Yu. Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Zhang, Qi. Health Sciences Institute, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Zhang, Qi. Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Liu, Wen-Jie. Health Sciences Institute, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Liu, Wen-Jie. School of Life Sciences, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Liu, Wen-Jie. Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Liu, Hui-Xin. Health Sciences Institute, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Liu, Hui-Xin. School of Life Sciences, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+ Liu, Hui-Xin. Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical Universitygrid.254145.3, Shenyang, Liaoning Province, People's Republic of China.
+MeSH Subject Headings
+ Female
+ Humans
+ *Gastrointestinal Microbiome
+ RNA, Ribosomal, 16S/ge [Genetics]
+ Obesity/mi [Microbiology]
+ *Endometrial Neoplasms
+ Feces/mi [Microbiology]
+ Biomarkers
+ Fatty Acids
+ Indole Alkaloids
+ TOR Serine-Threonine Kinases
+ Tumor Microenvironment
+Keyword Heading
+ biomarker
+ dysbiosis
+ host-microbe relationships
+ metabolic syndrome
+ microorganisms
+ obesity
+ tumor microenvironment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Endometrial cancer (EC) is the most prevalent gynecological malignancy, with a higher risk in obese woman, indicating the possibility of gut microbiota involvement in EC progression. However, no direct evidence of a relationship between EC and gut microbiota in humans has been discovered. Here, we performed 16S rRNA sequencing to explore the relationship between dysbiosis of gut microbiota and cancer development in different types of EC patients. The results clearly show the differential profiles of gut microbiota between EC patients and normal participants as well as the association between gut microbiota and EC progression. Targeted metabolomics of plasma revealed an increased level of C16:1 and C20:2, which was positively associated with the abundance of Ruminococcus sp. N15.MGS-57. The higher richness of Ruminococcus sp. N15.MGS-57 in EC subjects not only was positively associated with blood C16:1 and C20:2 but also was negatively correlated with betalain and indole alkaloid biosynthesis. Furthermore, the combined marker panel of gut bacteria, blood metabolites, and clinical indices could distinguish the EC patients under lean and overweight conditions from normal subjects with high accuracy in both discovery and validation sets. In addition, the alteration of tumor microenvironment metabolism of EC was characterized by imaging mass microscopy. Spatial visualization of fatty acids showed that C16:1 and C18:1 obviously accumulate in tumor tissue, and C16:1 may promote EC cell invasion and metastasis through mTOR signaling. The aberrant fecal microbiome, more specifically, Ruminococcus sp. N15.MGS-57 and spatially distributed C16:1 in EC tissues, can be used as a biomarker of clinical features and outcomes and provide a new therapeutic target for clinical treatment. IMPORTANCE A growing number of studies have shown the connection between gut microbiota, obesity, and cancer. However, to our knowledge, the association between gut microbiota and endometrial cancer progression in humans has not been studied. We recruited EC and control individuals as research participants and further subgrouped subjects by body mass index to examine the association between gut microbiota, metabolites, and clinical indices. The higher richness of Ruminococcus sp. N15.MGS-57 in EC subjects was not only positively associated with blood C16:1 but also negatively correlated with betalain and indole alkaloid biosynthesis. Spatial visualization of fatty acids by imaging mass microscopy showed that C16:1 obviously accumulates in tumor tissue, and C16:1 may promote the EC cell invasion and metastasis through mTOR signaling. The aberrant fecal microbiome, more specifically, Ruminococcus sp. N15.MGS-57 and spatially distributed C16:1, can be used as a biomarker of clinical features and outcomes and provide a new therapeutic target for clinical treatment.
+Registry Number/Name of Substance
+ 0 (RNA, Ribosomal, 16S). 0 (Biomarkers). 0 (Fatty Acids). 0 (Indole Alkaloids). EC 2-7-11-1 (TOR Serine-Threonine Kinases).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1128%2fspectrum.02612-22
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhao&issn=2165-0497&title=Microbiology+Spectrum&atitle=Altered+Gut+Microbial+Profile+Accompanied+by+Abnormal+Fatty+Acid+Metabolism+Activity+Exacerbates+Endometrial+Cancer+Progression.&volume=10&issue=6&spage=e0261222&epage=&date=2022&doi=10.1128%2Fspectrum.02612-22&pmid=36227107&sid=OVID:medline
+
+<397>
+Unique Identifier
+ 36209126
+Title
+ Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis.
+Source
+ Lipids in Health & Disease. 21(1):98, 2022 Oct 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pang Y; Zheng Y; Yang N; Zan M; Zhang L; Ding W
+Authors Full Name
+ Pang, Yueshan; Zheng, Yali; Yang, Ni; Zan, Meng; Zhang, Lu; Ding, WeiJun.
+Institution
+ Pang, Yueshan. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 611130, Chengdu, China.
+ Pang, Yueshan. The Second Clinical Medical College, North SiChuan Medical College, 637000, Nanchong, China.
+ Zheng, Yali. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 611130, Chengdu, China.
+ Yang, Ni. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 611130, Chengdu, China.
+ Zan, Meng. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 611130, Chengdu, China.
+ Zhang, Lu. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 611130, Chengdu, China.
+ Ding, WeiJun. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 611130, Chengdu, China. dingweijun@cdutcm.edu.cn.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Blood Glucose
+ Diet, High-Fat/ae [Adverse Effects]
+ Enkephalins
+ Intestine, Small/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ Obesity/me [Metabolism]
+ Phosphatidylcholines
+ *Phosphatidylethanolamines
+ Propanols
+ Tryptophan
+Keyword Heading
+ 5-HT
+ Cxcl10
+ Gut microbiota
+ High-fat diet
+ Obesity
+ Obesity resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although obesity is caused by different factors, individual susceptibility to obesity differs among people under the same circumstances. The microbiota in the caecum or fresh faeces and metabolites in blood or urine contribute to obesity resistance; however, the microbiota or metabolites in the small intestine have not been extensively studied.
+
+ METHODS: To investigate the relationship between the microbiota or metabolites in the small intestine and susceptibility to obesity, eighty-eight male C57BL/6 mice were fed a high-fat diet (HFD) for 8 weeks to establish two models of obesity and obesity resistance. For further study, six mice were chosen from among the obesity models, and twelve mice were randomly chosen from among the obesity resistance models. After fasting plasma glucose and behavioural testing, the mice were fed in single cages for another 4 weeks to observe their weight and food intake. All mice were sacrificed at 20 weeks of age. Serum ALT, AST, HDL, LDL, TG and TC levels were measured using an automatic biochemical analyser. The microbiota and metabolites in the small intestine contents were analysed using 16 S sequencing and an ultrahigh-performance liquid chromatographic system, respectively. Transcripts in the jejunum were evaluated using full-length transcriptome sequencing and verified by qPCR.
+
+ RESULTS: The results showed that HFD induced depression and anxiety behaviours and higher fasting plasma glucose, ALT, AST, HDL, LDL, TG and TC levels in the obese mice; however, these levels were improved in obese resistance mice. The correlation analysis showed that the phosphatidylcholine, TG, and phosphatidylethanolamine levels were higher in obese mice and correlated positively with intestinal microflora (Desulfovibrio and Gemella) and the Cxcl10 gene. A higher abundance of Clostridium_sensu_stricto_1 in obesity-resistant mice correlated negatively with the metabolite contents (neuromedin N and enkephalin L) and Pck1 gene expression and correlated positively with certain metabolites (5-hydroxy-L-tryptophan, cinnamyl alcohol and 1 H-indole-3-acetamide) and genes expression (Gdf15, Igfbp6 and Spp1).
+
+ CONCLUSION: Clostridium_sensu_stricto_1, neuromedin N, enkephalin L, Pck1, 5-hydroxy-L-tryptophan, Cxcl10 and cinnamyl alcohol may be novel biomarkers in the small intestine for obesity/obesity resistance. These might be helpful for obesity prevention or for treating obese patients. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Enkephalins). 0 (Phosphatidylcholines). 0 (Phosphatidylethanolamines). 0 (Propanols). 8DUH1N11BX (Tryptophan). SS8YOP444F (cinnamyl alcohol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12944-022-01711-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pang&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Potential+novel+biomarkers+in+small+intestine+for+obesity%2Fobesity+resistance+revealed+by+multi-omics+analysis.&volume=21&issue=1&spage=98&epage=&date=2022&doi=10.1186%2Fs12944-022-01711-0&pmid=36209126&sid=OVID:medline
+
+<398>
+Unique Identifier
+ 36203073
+Title
+ Can Leptin/Ghrelin Ratio and Retinol-Binding Protein 4 Predict Improved Insulin Resistance in Patients with Obesity Undergoing Sleeve Gastrectomy?.
+Source
+ Obesity Surgery. 32(12):3942-3950, 2022 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hany M; Demerdash HM; Agayby ASS; Ibrahim M; Torensma B
+Author NameID
+ Torensma, Bart; ORCID: https://orcid.org/0000-0003-0274-9608
+Authors Full Name
+ Hany, Mohamed; Demerdash, Hala M; Agayby, Ann Samy Shafiq; Ibrahim, Mohamed; Torensma, Bart.
+Institution
+ Hany, Mohamed. Department of Surgery, Medical Research Institute, Alexandria University, 165 Horreya Avenue, Hadara, 21561, Alexandria, Egypt. mohamed.ashour@alexu.edu.eg.
+ Demerdash, Hala M. Clinical Pathology, Alexandria University, Alexandria, Egypt.
+ Agayby, Ann Samy Shafiq. Medical Research Institute, Alexandria University, Alexandria, Egypt.
+ Ibrahim, Mohamed. Medical Research Institute, Alexandria University, Alexandria, Egypt.
+ Torensma, Bart. Leiden University Medical Center (LUMC), Leiden, The Netherlands.
+MeSH Subject Headings
+ Humans
+ *Insulin Resistance
+ Ghrelin
+ Leptin
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/su [Surgery]
+ *Diabetes Mellitus, Type 2
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+ Prospective Studies
+ Gastrectomy
+ Obesity/su [Surgery]
+ Insulin
+ Biomarkers
+Keyword Heading
+ HOMA-IR
+ Metabolic biomarkers
+ Prediction model
+ ROC curve
+ Sleeve gastrectomy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity is associated with metabolic syndrome (MBS), a cluster of components including central obesity, insulin resistance (IR), dyslipidemia, and hypertension. IR is the major risk factor in the development and progression of type 2 diabetes mellitus in obesity and MBS. Predicting preoperatively whether a patient with obesity would have improved or non-improved IR after bariatric surgery would improve treatment decisions.
+
+ METHODS: A prospective cohort study was conducted between August 2019 and September 2021. We identified pre- and postoperative metabolic biomarkers in patients who underwent laparoscopic sleeve gastrectomy. Patients were divided into two groups: group A (IR < 2.5), with improved IR, and group B (IR >= 2.5), with non-improved IR. A prediction model and receiver operating characteristics (ROC) were used to determine the effect of metabolic biomarkers on IR.
+
+ RESULTS: Seventy patients with obesity and MBS were enrolled. At 12-month postoperative a significant improvement in lipid profile, fasting blood glucose, and hormonal biomarkers and a significant reduction in the BMI in all patients (p = 0.008) were visible. HOMA-IR significantly decreased in 57.14% of the patients postoperatively. Significant effects on the change in HOMA-IR >= 2.5 were the variables; preoperative BMI, leptin, ghrelin, leptin/ghrelin ratio (LGr), insulin, and triglyceride with an OR of 1.6,1.82, 1.33, 1.69, 1.77, and 1.82, respectively (p = 0.009 towards p = 0.041). Leptin had the best predictive cutoff value on ROC (86% sensitivity and 92% specificity), whereas ghrelin had the lowest (70% sensitivity and 73% specificity).
+
+ CONCLUSION: Preoperative BMI, leptin, ghrelin, LGr, and increased triglycerides have a predictive value on higher postoperative, non-improved patients with HOMA-IR (>= 2.5). Therefore, assessing metabolic biomarkers can help decide on treatment/extra therapy and outcome before surgery. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Ghrelin). 0 (Leptin). 0 (Insulin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs11695-022-06296-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hany&issn=0960-8923&title=Obesity+Surgery&atitle=Can+Leptin%2FGhrelin+Ratio+and+Retinol-Binding+Protein+4+Predict+Improved+Insulin+Resistance+in+Patients+with+Obesity+Undergoing+Sleeve+Gastrectomy%3F.&volume=32&issue=12&spage=3942&epage=3950&date=2022&doi=10.1007%2Fs11695-022-06296-2&pmid=36203073&sid=OVID:medline
+
+<399>
+Unique Identifier
+ 36197242
+Title
+ Association between neutrophil-to-lymphocyte ratio and polycystic ovary syndrome: A PRISMA-compliant systematic review and meta-analysis.
+Source
+ Medicine. 101(38):e30579, 2022 Sep 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li L; Yu J; Zhou Z
+Author NameID
+ Zhou, Zhongwei; ORCID: https://orcid.org/0000-0003-1949-8198
+Authors Full Name
+ Li, Li; Yu, Jianxiu; Zhou, Zhongwei.
+Institution
+ Li, Li. Department of Clinical Laboratory, Binhai County People's Hospital, Binhai, China.
+ Yu, Jianxiu. Department of Clinical Laboratory, Binhai County People's Hospital, Binhai, China.
+ Zhou, Zhongwei. Department of Clinical Laboratory, Yancheng Third People's Hospital (The Affiliated Yancheng Hospital of Southeast University Medical College, The Sixth Affiliated Hospital of Nantong University, The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, China.
+MeSH Subject Headings
+ Biomarkers
+ Blood Glucose
+ Cholesterol
+ Female
+ Glycolipids
+ Humans
+ Lymphocytes
+ Neutrophils
+ Obesity/co [Complications]
+ Polycystic Ovary Syndrome/co [Complications]
+ *Polycystic Ovary Syndrome
+Abstract
+ BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) has been suggested to be a potential biomarker for assessing the systemic inflammatory response in polycystic ovary syndrome (PCOS). This meta-analysis is aimed at evaluating whether PCOS patients present with a higher NLR and whether obesity, metabolic, and hormonal indices have effects on the states.
+
+ METHODS: We performed a literature search on PubMed, Embase and Web of Science (last update: August 2, 2022). Pooled standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated by applying random-effects models. Meta-regression analyses were used to explore the sources of heterogeneity and assess the relationship between NLR and several clinical parameters. Sensitivity analysis and publication bias were also assessed.
+
+ RESULTS: Thirteen studies involving 826 PCOS patients and 780 healthy controls were eligible for the present meta-analysis. Generally, NLR significantly increased in PCOS women versus healthy women (SMD = 0.81, 95% CI = 0.30-1.33, P = .002). NLR disparity was subsequently investigated in obese and non-obese cohorts. Obese PCOS women exhibited a higher NLR than obese controls (SMD = 0.56, 95% CI = 0.24-0.87, P = .001), and a similar difference was shown between non-obese PCOS and non-obese controls (SMD = 0.36, 95% CI = 0.02-0.71, P = .038). No significant NLR disparity was observed between obese versus non-obese PCOS women (SMD = 0.50, 95% CI = -0.37 to 1.38, P = .259). Meta-regression analysis revealed that NLR was significantly positively associated with fasting blood glucose (P = .006) and total cholesterol levels (P = .021), but not correlated with body mass index and other parameters in PCOS patients. Sensitivity analysis indicated that no individual study significantly affected the overall pooled result, and no publishing bias was observed.
+
+ CONCLUSION: PCOS women typically present with an increased NLR. Such an increase is independent of obesity and may be associated with glycolipid metabolic disorders. Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycolipids). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1097%2fMD.0000000000030579
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=0025-7974&title=Medicine&atitle=Association+between+neutrophil-to-lymphocyte+ratio+and+polycystic+ovary+syndrome%3A+A+PRISMA-compliant+systematic+review+and+meta-analysis.&volume=101&issue=38&spage=e30579&epage=&date=2022&doi=10.1097%2FMD.0000000000030579&pmid=36197242&sid=OVID:medline
+
+<400>
+Unique Identifier
+ 36189989
+Title
+ Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism.
+Source
+ American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 323(5):R728-R738, 2022 11 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chae SA; Son JS; de Avila JM; Du M; Zhu MJ
+Author NameID
+ Chae, Song Ah; ORCID: https://orcid.org/0000-0002-5478-3528
+ Du, Min; ORCID: https://orcid.org/0000-0002-7232-072X
+ Zhu, Mei-Jun; ORCID: https://orcid.org/0000-0001-8027-1780
+Authors Full Name
+ Chae, Song Ah; Son, Jun Seok; de Avila, Jeanene Marie; Du, Min; Zhu, Mei-Jun.
+Institution
+ Chae, Song Ah. Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington.
+ Son, Jun Seok. Laboratory of Perinatal Kinesioepigenetics, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
+ de Avila, Jeanene Marie. Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington.
+ Du, Min. Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington.
+ Zhu, Mei-Jun. School of Food Science, Washington State University, Pullman, Washington.
+MeSH Subject Headings
+ Pregnancy
+ Female
+ Humans
+ Apelin/me [Metabolism]
+ AMP-Activated Protein Kinases/me [Metabolism]
+ *AMP-Activated Protein Kinases
+ Apelin Receptors/me [Metabolism]
+ Fetus/me [Metabolism]
+ Fetal Development
+ Obesity/me [Metabolism]
+ *Obesity, Maternal
+ Intestines
+ Biomarkers/me [Metabolism]
+ Oxidative Stress
+Keyword Heading
+ AMPK
+ exercise
+ fetal epithelium
+ maternal obesity
+ mitochondrial biogenesis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity in pregnancy is currently the leading cause of gestational complications for the mother and fetus worldwide. Maternal obesity (MO), common in western societies, impedes development of intestinal epithelium in the fetuses, which causes disorders in the nutrient absorption and intestine-related immune responses in offspring. Here, using a mouse model of maternal exercise (ME), we found that exercise during pregnancy protects the impairment of fetal intestinal morphometrical formation and epithelial development due to MO. MO decreased villus length and epithelial proliferation markers in E18.5 fetal small intestine, which was increased due to ME. The expression of the epithelial differentiation markers, Lyz1, Muc2, and Tff3, in fetal small intestine was decreased due to MO, but protected by ME. Consistently, the biomarkers related to mitochondrial biogenesis and oxidative metabolism were downregulated in MO fetal small intestine but recovered by ME. Apelin injection to dams partially mirrored the beneficial effects of ME. ME and apelin injection activated AMPK, the downstream target of apelin receptor signaling, which might mediate the improvement of fetal epithelial development and oxidative metabolism. These findings suggest that ME, a highly accessible intervention, is effective in improving fetal intestinal epithelium of obese dams. Apelin-AMPK-mitochondrial biogenesis axis provides amenable therapeutic targets to facilitate fetal intestinal development of obese mothers.
+Registry Number/Name of Substance
+ 0 (Apelin). EC 2-7-11-31 (AMP-Activated Protein Kinases). 0 (Apelin Receptors). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1152%2fajpregu.00128.2022
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chae&issn=0363-6119&title=American+Journal+of+Physiology+-+Regulatory+Integrative+%26+Comparative+Physiology&atitle=Maternal+exercise+improves+epithelial+development+of+fetal+intestine+by+enhancing+apelin+signaling+and+oxidative+metabolism.&volume=323&issue=5&spage=R728&epage=R738&date=2022&doi=10.1152%2Fajpregu.00128.2022&pmid=36189989&sid=OVID:medline
+
+<401>
+Unique Identifier
+ 36184236
+Title
+ Relationship between the creatinine/cystatin C ratio and muscle mass measured by CT-scan in cancer patients.
+Source
+ Clinical Nutrition ESPEN. 51:412-418, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tlemsani C; Durand JP; Raynard B; Revel MP; Deluche E; Di Palma M; Pigneur F; Goldwasser F
+Authors Full Name
+ Tlemsani, Camille; Durand, Jean-Philippe; Raynard, Bruno; Revel, Marie-Pierre; Deluche, Elise; Di Palma, Mario; Pigneur, Frederic; Goldwasser, Francois.
+Institution
+ Tlemsani, Camille. Oncology Department, Cochin Hospital, Universite Paris Cite, CARPEM, AP-HP, France. Electronic address: camille.tlemsani@aphp.fr.
+ Durand, Jean-Philippe. Oncology Department, Cochin Hospital, Universite Paris Cite, CARPEM, AP-HP, France.
+ Raynard, Bruno. Dietetic and Nutrition Unit, Cancer Campus Grand-Paris, Gustave-Roussy Cancer, Paris, France.
+ Revel, Marie-Pierre. Radiology Department, Cochin Hospital, Universite Paris Cite, CARPEM, AP-HP, France.
+ Deluche, Elise. Oncology Department, University Hospital, Limoges, France.
+ Di Palma, Mario. Ambulatory Oncology Unit, Cancer Campus Grand-Paris, Gustave-Roussy Cancer, Paris, France.
+ Pigneur, Frederic. Radiology Department, Henri-Mondor Hospital, AP-HP, Creteil, France.
+ Goldwasser, Francois. Oncology Department, Cochin Hospital, Universite Paris Cite, CARPEM, AP-HP, France; Laboratory URP 4466, PRETRAM, METHEHO, Universite Paris Cite, France.
+MeSH Subject Headings
+ *Antineoplastic Agents
+ Biomarkers
+ Creatinine
+ Cystatin C
+ Glomerular Filtration Rate/ph [Physiology]
+ Hand Strength
+ Humans
+ Kidney Diseases/di [Diagnosis]
+ *Kidney Diseases
+ Muscles
+ Neoplasms/co [Complications]
+ *Neoplasms
+ Obesity
+ Overweight
+ Sarcopenia/di [Diagnosis]
+ *Sarcopenia
+ Tomography, X-Ray Computed
+Keyword Heading
+ Cancer
+ Creatinine
+ Cystatin C
+ Sarcopenia
+ Sarcopenic obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Sarcopenia is observed in about 50% of cancer patients. Cancer-related sarcopenia negatively affects survival and is a predictive factor of anticancer drug toxicity. Sarcopenia diagnosis is challenging in routine care. We investigated whether plasma creatinine and cystatin C predict sarcopenia diagnosis in the specific population of cancer patients.
+
+ METHODS: Two common diagnostic criteria of cancer-related sarcopenia based on skeletal muscle mass +/- handgrip strength were separately applied as the "gold standard" sarcopenia definition. Four sarcopenia indexes based on creatinine and cystatin C values were evaluated: Creatinine/Cystatin C, Glomerular Filter rate (GFR) Cockroft-Gault/GFR CKD-EPI, GFR Cockroft-Gault/GFR Grubb and GFR Cockroft-Gault/GFR simple. The receiver operating characteristic (ROC) curves and the area under the ROC curves were applied to evaluate the sarcopenia diagnostic accuracy of the four different sarcopenia indexes.
+
+ RESULTS: A total of 99 patients were included. Among them, 47.5% were overweight or obese. The ratio creatinine/cystatin C (ratio value at 0.8) more accurately predicts the diagnosis of sarcopenia in the entire population based on low skeletal muscle mass and low handgrip strength (sensitivity, specificity, accuracy and Youden index at 0.77, 0.57, 0.90, 0.34 respectively). The other evaluated ratios predict sarcopenia with a lower specificity in all conditions. In the overweight/obese group, the results are similar. The ratio creatinine/cystatin C (ratio value at 1) accurately predicts sarcopenia with a sensitivity, a specificity, an accuracy and a Youden index at 0.50, 0.86, 0.95, 0.36 respectively in overweight/obese population.
+
+ CONCLUSIONS: The creatinine/cystatin C ratio is a useful and simple biomarker to predict sarcopenia in cancer patients. Moreover, this sarcopenia index also seems to be a strong sarcopenia diagnosis biomarker in overweight and obese cancer patients. Our results must be confirmed in a larger cohort. Copyright © 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antineoplastic Agents). 0 (Biomarkers). 0 (Cystatin C). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.clnesp.2022.07.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tlemsani&issn=2405-4577&title=Clinical+Nutrition+ESPEN&atitle=Relationship+between+the+creatinine%2Fcystatin+C+ratio+and+muscle+mass+measured+by+CT-scan+in+cancer+patients.&volume=51&issue=&spage=412&epage=418&date=2022&doi=10.1016%2Fj.clnesp.2022.07.010&pmid=36184236&sid=OVID:medline
+
+<402>
+Unique Identifier
+ 36184225
+Title
+ Orange juice intake by obese and insulin-resistant subjects lowers specific plasma triglycerides: A randomized clinical trial.
+Source
+ Clinical Nutrition ESPEN. 51:336-344, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Santos KGD; Yoshinaga MY; Glezer I; Chaves-Filho AB; Santana AA; Kovacs C; Magnoni CD; Lajolo FM; Miyamoto S; Aymoto Hassimotto NM
+Authors Full Name
+ Santos, Karina Gama Dos; Yoshinaga, Marcos Yukio; Glezer, Isaias; Chaves-Filho, Adriano de Britto; Santana, Aline Alves de; Kovacs, Cristiane; Magnoni, Carlos Daniel; Lajolo, Franco Maria; Miyamoto, Sayuri; Aymoto Hassimotto, Neuza Mariko.
+Institution
+ Santos, Karina Gama Dos. Food Research Center (FoRC), 05508-080, Sao Paulo, Brazil; School of Pharmaceutical Sciences (University of Sao Paulo), 05508-000, Sao Paulo, Brazil; Department of Clinical Nutrition, Dante Pazzanese Institute of Cardiology, 04012-090, Sao Paulo, Brazil. Electronic address: karina.gama@gmail.com.
+ Yoshinaga, Marcos Yukio. Department of Biochemistry, Institute of Chemistry (University of Sao Paulo), 05508-900, Sao Paulo, Brazil. Electronic address: marcosyukio@gmail.com.
+ Glezer, Isaias. Department of Biochemistry, Escola Paulista de Medicina (Federal University of Sao Paulo), Sao Paulo, Brazil.
+ Chaves-Filho, Adriano de Britto. Department of Biochemistry, Institute of Chemistry (University of Sao Paulo), 05508-900, Sao Paulo, Brazil.
+ Santana, Aline Alves de. Food Research Center (FoRC), 05508-080, Sao Paulo, Brazil; School of Pharmaceutical Sciences (University of Sao Paulo), 05508-000, Sao Paulo, Brazil.
+ Kovacs, Cristiane. Department of Clinical Nutrition, Dante Pazzanese Institute of Cardiology, 04012-090, Sao Paulo, Brazil.
+ Magnoni, Carlos Daniel. Department of Clinical Nutrition, Dante Pazzanese Institute of Cardiology, 04012-090, Sao Paulo, Brazil.
+ Lajolo, Franco Maria. Food Research Center (FoRC), 05508-080, Sao Paulo, Brazil; School of Pharmaceutical Sciences (University of Sao Paulo), 05508-000, Sao Paulo, Brazil.
+ Miyamoto, Sayuri. Department of Biochemistry, Institute of Chemistry (University of Sao Paulo), 05508-900, Sao Paulo, Brazil.
+ Aymoto Hassimotto, Neuza Mariko. Food Research Center (FoRC), 05508-080, Sao Paulo, Brazil; School of Pharmaceutical Sciences (University of Sao Paulo), 05508-000, Sao Paulo, Brazil.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cholesterol Esters
+ Citrus sinensis/me [Metabolism]
+ *Citrus sinensis
+ *Diabetes Mellitus, Type 2
+ Fatty Acids
+ Insulin
+ Insulin Resistance/ph [Physiology]
+ *Insulin Resistance
+ Linoleic Acids
+ Lipoproteins, LDL
+ Obesity
+ Triglycerides
+Keyword Heading
+ Insulin resistance
+ Obese subjects
+ Orange juice intake
+ Plasma lipidome profiling
+ Triglycerides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: Dyslipidaemia is usually common in obesity, insulin resistance, and type 2 diabetes mellitus. Clinical trials suggest that orange juice may have a positive impact on lipid metabolism and blood lipid profiles; however conflicting results have been reported. Here, we applied a combined untargeted/targeted lipidomic analysis of plasma to examine the impact of orange (Citrus sinensis) juice intake on the lipidome profile of obese and insulin-resistant subjects.
+
+ METHODS: Twenty-five participants, both sexes, aged 40-60 years, with obesity and insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR) index >2.71) ingested 400 mL of orange juice 'Pera' (C. sinensis) for 15 d. Cardiometabolic biomarkers, anthropometric parameters, blood pressure, and plasma lipidomic analysis results were assessed at the beginning and end of the intervention.
+
+ RESULTS: After the 15-d intervention, a significant decrease was observed in the diastolic blood pressure and blood lipid profile. Among plasma lipidomes, 316 lipid molecules were identified, with the triglycerides (TGs) subclass being the most abundant (n = 106). Plasma lipidome profiling revealed a major signature of the intervention; with concentrations of 37 TG species decreasing after intervention. Qualitatively, oleic and linoleic acids were among the most prevalent fatty acids linked to the altered TG species, representing 50% of TG chains. Modulated TG species were positively correlated with total TG and very low-density lipoprotein levels, as well as systolic and diastolic blood pressure. A strong inter-individual trend was observed, wherein, compared with less responsive subjects, the high responsive subjects displayed the highest decrease in the concentrations of altered TG species, as as well as systolic blood pressure (decrease of 10.3 +/- 6.8 mmHg) and body weight (decrease of 0.67 +/- 0.71 kg).
+
+ CONCLUSIONS: These findings suggest that orange juice has a positive impact on lipid metabolism, mainly regarding the composition of TG-specific fatty acid chains and cholesterol esters, protecting against insulin resistance. Furthermore, lipidomics may help clarify alterations at the molecular level after an intervention, contributing to improve the evaluation of the link between dyslipidaemia, insulin resistance, and nutrition. Copyright © 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol Esters). 0 (Fatty Acids). 0 (Insulin). 0 (Linoleic Acids). 0 (Lipoproteins, LDL). 0 (Triglycerides).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.clnesp.2022.08.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Santos&issn=2405-4577&title=Clinical+Nutrition+ESPEN&atitle=Orange+juice+intake+by+obese+and+insulin-resistant+subjects+lowers+specific+plasma+triglycerides%3A+A+randomized+clinical+trial.&volume=51&issue=&spage=336&epage=344&date=2022&doi=10.1016%2Fj.clnesp.2022.08.005&pmid=36184225&sid=OVID:medline
+
+<403>
+Unique Identifier
+ 36184152
+Title
+ Amelioration of hydrolyzed guar gum on high-fat diet-induced obesity: Integrated hepatic transcriptome and metabolome.
+Source
+ Carbohydrate Polymers. 297:120051, 2022 Dec 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fu X; Liu Z; Li R; Yin J; Sun H; Zhu C; Kong Q; Mou H; Nie S
+Authors Full Name
+ Fu, Xiaodan; Liu, Zhemin; Li, Rong; Yin, Junyi; Sun, Han; Zhu, Changliang; Kong, Qing; Mou, Haijin; Nie, Shaoping.
+Institution
+ Fu, Xiaodan. State Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, Jiangxi, People's Republic of China.
+ Liu, Zhemin. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, People's Republic of China.
+ Li, Rong. Qingdao Women and Children's Hospital, Qingdao 266034, Shandong, People's Republic of China.
+ Yin, Junyi. State Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, Jiangxi, People's Republic of China.
+ Sun, Han. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, People's Republic of China.
+ Zhu, Changliang. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, People's Republic of China.
+ Kong, Qing. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, People's Republic of China.
+ Mou, Haijin. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, People's Republic of China. Electronic address: mousun@ouc.edu.cn.
+ Nie, Shaoping. State Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, Jiangxi, People's Republic of China. Electronic address: spnie@ncu.edu.cn.
+MeSH Subject Headings
+ Animals
+ Anti-Obesity Agents/pd [Pharmacology]
+ *Anti-Obesity Agents
+ Biomarkers/me [Metabolism]
+ Choline/pd [Pharmacology]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ Fatty Acids/pd [Pharmacology]
+ Flavin-Adenine Dinucleotide/me [Metabolism]
+ Flavin-Adenine Dinucleotide/pd [Pharmacology]
+ Flavin-Adenine Dinucleotide/tu [Therapeutic Use]
+ Galactans
+ Glycerophospholipids/me [Metabolism]
+ Glycerophospholipids/pd [Pharmacology]
+ Glycerophospholipids/tu [Therapeutic Use]
+ Lipid Metabolism
+ Lipids
+ Liver
+ Mannans
+ Metabolome
+ Mice
+ Mice, Inbred C57BL
+ Neopterin/me [Metabolism]
+ Neopterin/pd [Pharmacology]
+ Neopterin/tu [Therapeutic Use]
+ Obesity/ci [Chemically Induced]
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Pantetheine/me [Metabolism]
+ Pantetheine/pd [Pharmacology]
+ Pantetheine/tu [Therapeutic Use]
+ Plant Gums
+ Transcriptome
+ Triglycerides
+Keyword Heading
+ Fatty acid metabolism
+ Hepatic metabolome
+ Hepatic transcriptome
+ Hyperlipidemia
+ Low molecular weight hydrolyzed guar gum
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Hydrolyzed guar gum has gained attention as an anti-obesity agent; however, few studies have focused on its role in amelioration of hepatic-associated metabolic processes. Here, the anti-obesity effect of low molecular weight hydrolyzed guar gum (GMLP, 1-10 kDa) on high-fat diet (HFD)-fed C57BL/6 J mice was investigated via transcriptome and metabolome in liver. GMLP reduced body weight gain and hepatic lipid accumulation dose-dependently, regulated blood lipid levels, and improved liver damage in HFD-fed mice. Integrated transcriptome and metabolome indicated that GMLP mainly altered lipid metabolism pathways (glycerophospholipid metabolism, glycerolipid metabolism, and fatty acid degradation), reduced disease biomarkers of ethyl glucuronide and neopterin, and increased levels of choline, flavin adenine dinucleotide, and pantetheine metabolites. Real-time quantitative PCR showed that GMLP downregulated key genes involved in de novo lipogenesis and triacylglycerol synthesis, while promoting fatty acid oxidation and choline synthesis. This study provides a theoretical basis for GMLP treatment in future clinical applications. Copyright © 2022 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Fatty Acids). 0 (Galactans). 0 (Glycerophospholipids). 0 (Lipids). 0 (Mannans). 0 (Plant Gums). 0 (Triglycerides). 146-14-5 (Flavin-Adenine Dinucleotide). 496-65-1 (Pantetheine). 670-65-5 (Neopterin). E89I1637KE (guar gum). N91BDP6H0X (Choline).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.carbpol.2022.120051
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fu&issn=0144-8617&title=Carbohydrate+Polymers&atitle=Amelioration+of+hydrolyzed+guar+gum+on+high-fat+diet-induced+obesity%3A+Integrated+hepatic+transcriptome+and+metabolome.&volume=297&issue=&spage=120051&epage=&date=2022&doi=10.1016%2Fj.carbpol.2022.120051&pmid=36184152&sid=OVID:medline
+
+<404>
+Unique Identifier
+ 36183353
+Title
+ PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults.
+Source
+ FASEB Journal. 36(11):e22578, 2022 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bogaards FA; Gehrmann T; Beekman M; van den Akker EB; van de Rest O; Hangelbroek RWJ; Noordam R; Mooijaart SP; de Groot LCPGM; Reinders MJT; Slagboom PE
+Author NameID
+ Bogaards, Fatih A; ORCID: https://orcid.org/0000-0003-2553-5346
+ Gehrmann, Thies; ORCID: https://orcid.org/0000-0003-4666-5406
+ Beekman, Marian; ORCID: https://orcid.org/0000-0003-0585-6206
+ van den Akker, Erik Ben; ORCID: https://orcid.org/0000-0002-7693-0728
+ van de Rest, Ondine; ORCID: https://orcid.org/0000-0002-4632-7418
+ Hangelbroek, Roland W J; ORCID: https://orcid.org/0000-0002-0442-5378
+ Noordam, Raymond; ORCID: https://orcid.org/0000-0001-7801-809X
+ Mooijaart, Simon P; ORCID: https://orcid.org/0000-0003-3106-3568
+ de Groot, Lisette C P G M; ORCID: https://orcid.org/0000-0003-2778-2789
+ Reinders, Marcel J T; ORCID: https://orcid.org/0000-0002-1148-1562
+ Slagboom, P Eline; ORCID: https://orcid.org/0000-0002-2875-4723
+Authors Full Name
+ Bogaards, Fatih A; Gehrmann, Thies; Beekman, Marian; van den Akker, Erik Ben; van de Rest, Ondine; Hangelbroek, Roland W J; Noordam, Raymond; Mooijaart, Simon P; de Groot, Lisette C P G M; Reinders, Marcel J T; Slagboom, P Eline.
+Institution
+ Bogaards, Fatih A. Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
+ Bogaards, Fatih A. Leiden Computational Biology Center, Leiden, The Netherlands.
+ Bogaards, Fatih A. Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
+ Gehrmann, Thies. Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
+ Gehrmann, Thies. Leiden Computational Biology Center, Leiden, The Netherlands.
+ Beekman, Marian. Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
+ van den Akker, Erik Ben. Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
+ van den Akker, Erik Ben. Leiden Computational Biology Center, Leiden, The Netherlands.
+ van den Akker, Erik Ben. Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.
+ van de Rest, Ondine. Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
+ Hangelbroek, Roland W J. Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
+ Noordam, Raymond. Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
+ Mooijaart, Simon P. Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
+ de Groot, Lisette C P G M. Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
+ Reinders, Marcel J T. Leiden Computational Biology Center, Leiden, The Netherlands.
+ Reinders, Marcel J T. Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.
+ Slagboom, P Eline. Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Cholesterol, HDL
+ Female
+ Humans
+ Insulin
+ *Life Style
+ Male
+ *Obesity
+Keyword Heading
+ bioinformatics
+ healthy ageing
+ lifestyle intervention
+ machine learning
+ metabolomics
+ response monitor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The response to lifestyle intervention studies is often heterogeneous, especially in older adults. Subtle responses that may represent a health gain for individuals are not always detected by classical health variables, stressing the need for novel biomarkers that detect intermediate changes in metabolic, inflammatory, and immunity-related health. Here, our aim was to develop and validate a molecular multivariate biomarker maximally sensitive to the individual effect of a lifestyle intervention; the Personalized Lifestyle Intervention Status (PLIS). We used 1 H-NMR fasting blood metabolite measurements from before and after the 13-week combined physical and nutritional Growing Old TOgether (GOTO) lifestyle intervention study in combination with a fivefold cross-validation and a bootstrapping method to train a separate PLIS score for men and women. The PLIS scores consisted of 14 and four metabolites for females and males, respectively. Performance of the PLIS score in tracking health gain was illustrated by association of the sex-specific PLIS scores with several classical metabolic health markers, such as BMI, trunk fat%, fasting HDL cholesterol, and fasting insulin, the primary outcome of the GOTO study. We also showed that the baseline PLIS score indicated which participants respond positively to the intervention. Finally, we explored PLIS in an independent physical activity lifestyle intervention study, showing similar, albeit remarkably weaker, associations of PLIS with classical metabolic health markers. To conclude, we found that the sex-specific PLIS score was able to track the individual short-term metabolic health gain of the GOTO lifestyle intervention study. The methodology used to train the PLIS score potentially provides a useful instrument to track personal responses and predict the participant's health benefit in lifestyle interventions similar to the GOTO study. Copyright © 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1096%2ffj.202201037R
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bogaards&issn=0892-6638&title=FASEB+Journal&atitle=PLIS%3A+A+metabolomic+response+monitor+to+a+lifestyle+intervention+study+in+older+adults.&volume=36&issue=11&spage=e22578&epage=&date=2022&doi=10.1096%2Ffj.202201037R&pmid=36183353&sid=OVID:medline
+
+<405>
+Unique Identifier
+ 36179769
+Title
+ Fat-Free Mass Index as a Surrogate Marker of Appendicular Skeletal Muscle Mass Index for Low Muscle Mass Screening in Sarcopenia.
+Source
+ Journal of the American Medical Directors Association. 23(12):1955-1961.e3, 2022 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kawakami R; Tanisawa K; Ito T; Usui C; Miyachi M; Torii S; Midorikawa T; Ishii K; Muraoka I; Suzuki K; Sakamoto S; Higuchi M; Oka K
+Authors Full Name
+ Kawakami, Ryoko; Tanisawa, Kumpei; Ito, Tomoko; Usui, Chiyoko; Miyachi, Motohiko; Torii, Suguru; Midorikawa, Taishi; Ishii, Kaori; Muraoka, Isao; Suzuki, Katsuhiko; Sakamoto, Shizuo; Higuchi, Mitsuru; Oka, Koichiro.
+Institution
+ Kawakami, Ryoko. Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Kanagawa, Japan; Department of Genetic Medicine, Kanagawa Cancer Center, Kanagawa, Japan; Waseda Institute for Sport Sciences, Waseda University, Saitama, Japan. Electronic address: kawakami@gancen.asahi.yokohama.jp.
+ Tanisawa, Kumpei. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+ Ito, Tomoko. Waseda Institute for Sport Sciences, Waseda University, Saitama, Japan; Department of Food and Nutrition, Tokyo Kasei University, Tokyo, Japan.
+ Usui, Chiyoko. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+ Miyachi, Motohiko. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+ Torii, Suguru. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+ Midorikawa, Taishi. Waseda Institute for Sport Sciences, Waseda University, Saitama, Japan; College of Health and Welfare, J. F. Oberlin University, Tokyo, Japan.
+ Ishii, Kaori. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+ Muraoka, Isao. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+ Suzuki, Katsuhiko. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+ Sakamoto, Shizuo. Faculty of Sport Sciences, Waseda University, Saitama, Japan; Faculty of Sport Science, Surugadai University, Saitama, Japan.
+ Higuchi, Mitsuru. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+ Oka, Koichiro. Faculty of Sport Sciences, Waseda University, Saitama, Japan.
+MeSH Subject Headings
+ Female
+ Humans
+ Middle Aged
+ Aged
+ Cross-Sectional Studies
+ Biomarkers
+ *Obesity
+ *Muscle, Skeletal
+ Mass Screening
+Keyword Heading
+ Bioelectrical impedance
+ body composition
+ calf circumference
+ diagnosis
+ dual-energy X-ray absorptiometry scan
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: We aimed to examine the relationship between the fat-free mass index (FFMI; FFM/height2) and appendicular skeletal muscle mass index (ASMI; ASM/height2), measured using both bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA), and investigate the effects of age and obesity. We also evaluated the suitability of BIA-measured FFMI as a simple surrogate marker of the ASMI and calculated the optimal FFMI cutoff value for low muscle mass screening to diagnose sarcopenia.
+
+ DESIGN: Cross-sectional study.
+
+ SETTING AND PARTICIPANTS: This study included 1313 adults (women, 33.6%) aged 40-87 years (mean age, 55 +/- 10 years) from the WASEDA'S Health Study.
+
+ METHODS: Body composition was measured using multifrequency BIA and DXA. Low muscle mass was defined according to the criteria of the Asian Working Group for Sarcopenia 2019.
+
+ RESULTS: BIA-measured FFMI showed strong positive correlations with both BIA- (r = 0.96) and DXA-measured (r = 0.95) ASMIs. Similarly, in the subgroup analysis according to age and obesity, the FFMI was correlated with the ASMI. The areas under the receiver operating characteristic curve for screening low muscle mass defined by DXA-measured ASMI using BIA-measured FFMI values were 0.95 (95% CI 0.93-0.97) for men and 0.91 (95% CI 0.87-0.94) for women. The optimal BIA-measured FFMI cutoff values for screening low muscle mass defined by DXA-measured ASMI were 17.5 kg/m2 (sensitivity 89%, specificity 88%) for men and 14.6 kg/m2 (sensitivity 80%, specificity 86%) for women.
+
+ CONCLUSIONS AND IMPLICATIONS: The FFMI showed a strong positive correlation with BIA- and DXA-measured ASMIs, regardless of age and obesity. The FFMI could be a useful simple surrogate marker of the ASMI for low muscle mass screening in sarcopenia in community settings. The suggested FFMI cutoff values for predicting low muscle mass are <18 kg/m2 in men and <15 kg/m2 in women. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.jamda.2022.08.016
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kawakami&issn=1525-8610&title=Journal+of+the+American+Medical+Directors+Association&atitle=Fat-Free+Mass+Index+as+a+Surrogate+Marker+of+Appendicular+Skeletal+Muscle+Mass+Index+for+Low+Muscle+Mass+Screening+in+Sarcopenia.&volume=23&issue=12&spage=1955&epage=1961.e3&date=2022&doi=10.1016%2Fj.jamda.2022.08.016&pmid=36179769&sid=OVID:medline
+
+<406>
+Unique Identifier
+ 36173650
+Title
+ Fat, adipokines, bone structure and bone regulatory factors associations in obesity.
+Source
+ European Journal of Endocrinology. 187(6):743-750, 2022 Dec 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vilaca T; Evans A; Gossiel F; Paggiosi M; Eastell R; Walsh JS
+Author NameID
+ Vilaca, T; ORCID: https://orcid.org/0000-0002-9227-6076
+Authors Full Name
+ Vilaca, T; Evans, A; Gossiel, F; Paggiosi, M; Eastell, R; Walsh, J S.
+Institution
+ Vilaca, T. Mellanby Centre for Bone Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
+ Evans, A. Mellanby Centre for Bone Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
+ Gossiel, F. Mellanby Centre for Bone Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
+ Paggiosi, M. Mellanby Centre for Bone Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
+ Eastell, R. Mellanby Centre for Bone Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
+ Walsh, J S. Mellanby Centre for Bone Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
+MeSH Subject Headings
+ Adult
+ Female
+ Humans
+ Male
+ Absorptiometry, Photon/mt [Methods]
+ Adipokines
+ Adiponectin
+ Biomarkers
+ Bone Density
+ Case-Control Studies
+ Cross-Sectional Studies
+ Insulin-Like Growth Factor I
+ *Insulins
+ Leptin
+ Obesity
+ Parathyroid Hormone
+ *Procollagen
+ Middle Aged
+ Aged
+Abstract
+ Context: Obese (OB) adults (BMI >= 30) have a higher bone mineral density (BMD) and more favourable bone microarchitecture than normal-weight (NW) adults (BMI 18.5-24.9).
+
+ Objective: The objective of this study was to identify which fat compartments have the strongest association with bone density and bone turnover and whether biochemical factors (adipokines, hormones and bone regulators) are likely to be important mediators of the effect of obesity on bone.
+
+ Design: This was a cross-sectional, observational, matched case-control study.
+
+ Setting: Participants were recruited from the local community.
+
+ Participants: Two hundred healthy men and women aged 25-40 or 55-75 were recruited in individually matched OB and NW pairs. Body composition, BMD and bone microarchitecture were determined by dual-energy X-ray absorptiometry (DXA), computed tomography (CT) and high-resolution peripheral CT (HR-pQCT). Bone turnover and potential regulators such as C-terminal cross-linking telopeptide (CTX), type 1 procollagen N-terminal peptide (PINP), sclerostin, periostin, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), insulin-like growth factor 1 (IGF1), adiponectin, leptin and insulin were assessed.
+
+ Main outcome: Planned exploratory analysis of the relationships between fat compartments, areal and volumetric BMD, bone microarchitecture, bone turnover markers and bone regulators.
+
+ Results: Compared with NW, OB had lower CTX, PINP, adiponectin, IGF1, and 25OHD and higher leptin, PTH and insulin (all P < 0.05). CTX and subcutaneous adipose tissue (SAT) were the bone marker and fat compartment most consistently associated with areal and volumetric BMD. In regression models, SAT was negatively associated with CTX (P < 0.001). When leptin was added to the model, SAT was no longer associated with CTX, but leptin (P < 0.05) was negatively associated with CTX.
+
+ Conclusions: SAT is associated with lower bone resorption and properties favourable for bone strength in obesity. Leptin may be an important mediator of the effects of SAT on the skeleton.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 67763-96-6 (Insulin-Like Growth Factor I). 0 (Insulins). 0 (Leptin). 0 (Parathyroid Hormone). 0 (Procollagen).
+Publication Type
+ Observational Study. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1530%2fEJE-22-0530
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vilaca&issn=0804-4643&title=European+Journal+of+Endocrinology&atitle=Fat%2C+adipokines%2C+bone+structure+and+bone+regulatory+factors+associations+in+obesity.&volume=187&issue=6&spage=743&epage=750&date=2022&doi=10.1530%2FEJE-22-0530&pmid=36173650&sid=OVID:medline
+
+<407>
+Unique Identifier
+ 36171904
+Title
+ Inverse association between blood ethylene oxide levels and obesity in the general population: NHANES 2013-2016.
+Source
+ Frontiers in Endocrinology. 13:926971, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cheang I; Zhu X; Zhu Q; Li M; Liao S; Zuo Z; Yao W; Zhou Y; Zhang H; Li X
+Authors Full Name
+ Cheang, Iokfai; Zhu, Xu; Zhu, Qingqing; Li, Menghuan; Liao, Shengen; Zuo, Zhi; Yao, Wenming; Zhou, Yanli; Zhang, Haifeng; Li, Xinli.
+Institution
+ Cheang, Iokfai. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Zhu, Xu. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Zhu, Qingqing. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Li, Menghuan. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Liao, Shengen. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Zuo, Zhi. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Yao, Wenming. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Zhou, Yanli. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Zhang, Haifeng. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+ Zhang, Haifeng. Department of Cardiology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
+ Li, Xinli. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
+MeSH Subject Headings
+ Adult
+ Alkaline Phosphatase
+ Biomarkers
+ Cross-Sectional Studies
+ *Ethylene Oxide
+ Female
+ Hemoglobins
+ Humans
+ Male
+ Nutrition Surveys
+ Obesity/co [Complications]
+ Obesity, Abdominal/co [Complications]
+ Obesity, Abdominal/ep [Epidemiology]
+ *Obesity, Abdominal
+Keyword Heading
+ NHANES
+ abdominal obesity
+ epidemiology
+ ethylene oxide (EO)
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Ethylene oxide (EO) has been shown to associate with increased cardiovascular risk. This study aimed to explore the relationship and its meditating factors between EO exposure and the major cardiovascular risk factor of obesity among the general adult population.
+
+ Methods: Cross-sectional data of 3,220 participants from National Health and Nutritional Examination Survey (NHANES) 2013-2016 were enrolled. Obesity was defined as body mass index (BMI) >=30 kg/m2, and abdominal obesity was defined as waist circumference (WC) >=102 cm in men and >=88 cm in women. The association among hemoglobin adduct of EO (HbEO), inflammatory biomarkers, and obesity was evaluated using restricted cubic splines and the multivariable linear regression model. Mediation analysis was used to further assess their association.
+
+ Results: The increased quartiles of HbEO were inversely associated with BMI and WC [Q1 vs. Q4, BMI: beta = -2.98 (-3.74, -2.22), WC: beta = -6.50 (-8.60, -4.39); all p for trend < 0.05], and were inversely associated with obesity after full adjustment [obesity: OR = 0.43 (0.31, 0.58), abdominal obesity: OR = 0.42 (0.27, 0.65); all p for trend < 0.05]. The levels of alkaline phosphatase, white blood cells, lymphocytes, and neutrophils were also positively associated with BMI and WC (all p < 0.05). Mediation analysis showed that exposure of EO not only had a negative direct effect on BMI and WC, but also generated an inverse indirect effect.
+
+ Conclusions: Current findings showed an inverse association between HbEO and obesity, and suggested that systemic inflammation may not be their only mediator. Additional research is required to explore the underlying link of EO and system metabolism. Copyright © 2022 Cheang, Zhu, Zhu, Li, Liao, Zuo, Yao, Zhou, Zhang and Li.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hemoglobins). EC 3-1-3-1 (Alkaline Phosphatase). JJH7GNN18P (Ethylene Oxide).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.926971
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cheang&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Inverse+association+between+blood+ethylene+oxide+levels+and+obesity+in+the+general+population%3A+NHANES+2013-2016.&volume=13&issue=&spage=926971&epage=&date=2022&doi=10.3389%2Ffendo.2022.926971&pmid=36171904&sid=OVID:medline
+
+<408>
+Unique Identifier
+ 36151266
+Title
+ Longitudinal analyses of serum neurofilament light and associations with obesity indices and bioelectrical impedance parameters.
+Source
+ Scientific Reports. 12(1):15863, 2022 09 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hermesdorf M; Leppert D; Maceski A; Benkert P; Wellmann J; Wiendl H; Kuhle J; Berger K
+Authors Full Name
+ Hermesdorf, Marco; Leppert, David; Maceski, Aleksandra; Benkert, Pascal; Wellmann, Jurgen; Wiendl, Heinz; Kuhle, Jens; Berger, Klaus.
+Institution
+ Hermesdorf, Marco. Institute of Epidemiology and Social Medicine, University of Munster, Albert-Schweitzer-Campus 1, 48149, Munster, Germany. hermesdorf@uni-muenster.de.
+ Leppert, David. Multiple Sclerosis Centre, Neurology, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
+ Leppert, David. Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), University Hospital and University of Basel, Basel, Switzerland.
+ Maceski, Aleksandra. Multiple Sclerosis Centre, Neurology, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
+ Maceski, Aleksandra. Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), University Hospital and University of Basel, Basel, Switzerland.
+ Benkert, Pascal. Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Wellmann, Jurgen. Institute of Epidemiology and Social Medicine, University of Munster, Albert-Schweitzer-Campus 1, 48149, Munster, Germany.
+ Wiendl, Heinz. Department of Neurology with Institute of Translational Neurology, University Hospital Munster, Munster, Germany.
+ Kuhle, Jens. Multiple Sclerosis Centre, Neurology, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
+ Kuhle, Jens. Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), University Hospital and University of Basel, Basel, Switzerland.
+ Berger, Klaus. Institute of Epidemiology and Social Medicine, University of Munster, Albert-Schweitzer-Campus 1, 48149, Munster, Germany.
+MeSH Subject Headings
+ Biomarkers
+ Electric Impedance
+ Humans
+ *Intermediate Filaments
+ *Neurofilament Proteins
+ Obesity
+ Serum
+Abstract
+ Neurofilament light is a constituent of the neuronal cytoskeleton and released into the blood following neuro-axonal damage. It has previously been reported that NfL measured in blood serum is inversely related to body mass index. However, no reports exist with regard to body composition assessed using bioelectrical impedance analysis or other indicators of obesity beyond BMI. We analyzed the relationship between sNfL and body composition according to the three compartment model. Additionally, associations between sNfL, body shape index, waist-to-height ratio, and BMI were examined. The sample consisted of 769 participants assessed during the baseline examination and 693 participants examined in the course of the follow-up of the BiDirect Study. Associations between sNfL, BMI, BSI, and WtHR were separately analyzed using linear mixed models. Body compartments operationalized as fat mass, extracellular cell mass, and body cell mass were derived using BIA and the relationship with sNfL was analyzed with a linear mixed model. Lastly, we also analyzed the association between total body water and sNfL. We found significant inverse associations of sNfL with BMI and WtHR. The analysis of the three compartment model yielded significant inverse associations between sNfL, body cell mass and body fat mass, but not extracellular mass. Furthermore, total body water was also inversely related to sNfL. A potential mechanism could involve body cell mass and body fat mass as highly adaptive body constituents that either directly absorb sNfL, or promote the formation of new vasculature and thereby increase blood volume. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Neurofilament Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41598-022-20398-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hermesdorf&issn=2045-2322&title=Scientific+Reports&atitle=Longitudinal+analyses+of+serum+neurofilament+light+and+associations+with+obesity+indices+and+bioelectrical+impedance+parameters.&volume=12&issue=1&spage=15863&epage=&date=2022&doi=10.1038%2Fs41598-022-20398-y&pmid=36151266&sid=OVID:medline
+
+<409>
+Unique Identifier
+ 36149065
+Title
+ [Cut-off points of anthropometric markers for hypertension and hyperglycemia in Argentine adults: a cross-sectional study from the 4th ENFR]. [Spanish]
+Original Title
+ Puntos de corte de indicadores antropometricos para hipertension e hiperglucemia en adultos argentinos
+Source
+ Revista de la Facultad de Ciencias Medicas de Cordoba. 79(3):260-266, 2022 09 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Farinola MG; Sganga M
+Authors Full Name
+ Farinola, Martin Gustavo; Sganga, Magali.
+Institution
+ Farinola, Martin Gustavo. Laboratorio de Actividad y Aptitud Fisica "Lic. Pedro P. Giorno", ISEF N2 "Federico F. Dickens", Ministerio de Educacion, CABA.. farinolamartin@institutodickens.edu.ar.
+ Sganga, Magali. Centro de Estudios Biomedicos, Basicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimonides.. sgangamagali@gmail.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Blood Glucose
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Humans
+ Hyperglycemia/co [Complications]
+ Hyperglycemia/di [Diagnosis]
+ *Hyperglycemia
+ Hypertension/co [Complications]
+ *Hypertension
+ Male
+ Obesity/co [Complications]
+ ROC Curve
+ Risk Factors
+ Waist Circumference
+ Waist-Height Ratio
+Keyword Heading
+ anthropometry
+ blood glucose
+ arterial pressure
+ Argentina
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction: High waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) are associated with increased cardiometabolic risk. The objective was to identify anthropometric cut-off points that allow discriminating subjects at increased risk of presenting high blood pressure and glycemia in Argentine adults.
+
+ Methods: The results of the 4th Argentine ENFR were used. Subjects aged 18 to 65 years who had blood pressure, blood glucose, and anthropometry directly measured were included (n=4254 and 1683 subjects of both sexes for high blood pressure and blood glucose, respectively). The area under the ROC curve was calculated. The optimal cut-off point was the one with the smallest difference between sensitivity and specificity. Adjusted odds ratios (aOR) were calculated for each point.
+
+ Results: In men, the cut-off points for high blood pressure were WC=91.5 cm (aOR= 3.55; 95% CI=2.97-4.24), WHtR=0.541 (aOR=3.12; 95% CI =2.61-3.73) and BMI=27.0 kg/m2 (aOR=3.04; CI95%=2.55-3.63); and for high blood glucose WC=94.5 cm (aOR=2.46; 95% CI=1.64-3.70), WHtR =0.559 (aOR=2.35; 95% CI=1.55-3.55) and BMI=28.6 kg/m2 (aOR= 3.23; CI95%=2.14-4.88). In women, for high blood pressure, WC=88.5 cm (aOR=3.57; 95% CI=2.84-4.41), WHtR=0.542 (aOR=3.45; 95% CI=2.79- 4.27) and BMI=26.7 kg/m2 (aOR=3.25; CI95%=2.64-4.02); and for high blood glucose WC=93.5 cm (aOR=4.28; 95% CI=2.72-6.75), WHtR =0.573 (aOR=3.61; 95% CI=2.31-5.66) and BMI=27.8 kg/m2 (aOR= 3.14; CI95%=2.03-4.87).
+
+ Conclusion: Argentine adults who have WC measured on the skin and are above the cut-off points identified here, have a significantly higher risk of presenting high blood pressure and hiperglycemia. Copyright Universidad Nacional de Cordoba.
+Other Abstract
+ Publisher
+ Introduccion: Circunferencia de cintura (CC), indice cintura/talla (ICT) e indice de masa corporal (IMC) elevados se relacionan con mayor riesgo cardiometabolico. El objetivo fue identificar puntos de corte antropometricos que permitan discriminar a sujetos en riesgo aumentado de presentar tension arterial y glucemia elevadas en adultos argentinos.
+ Metodos: Se utilizaron los resultados de la 4ta ENFR argentina. Se incluyeron sujetos de 18 a 65 anos a quienes se les haya medido directamente tension arterial, glucemia y antropometria (n=4.254 y 1.683 sujetos de ambos sexos para tension arterial y glucemia elevadas respectivamente). Se calculo el area bajo la curva ROC. El punto de corte optimo fue el que presento menor diferencia entre sensibilidad y especificidad. Se calcularon odds ratios ajustados (ORa) para cada punto.
+ Resultados: En varones los puntos de corte para tension arterial elevada fueron CC=91,5 cm (ORa=3,55; IC95%=2,97-4,24), ICT=0,541 (ORa=3,12; IC95%=2,61-3,73) e IMC=27,0 kg/m2 (ORa=3,04; IC95%=2,55-3,63); y para glucemia elevada CC=94,5 cm (ORa=2,46; IC95%=1,64-3,70), ICT=0,559 (ORa=2,35; IC95%=1,55-3,55) e IMC=28,6 kg/m2 (ORa= 3,23; IC95%=2,14-4,88). En mujeres, para tension arterial elevada fueron CC=88,5 cm (ORa=3,57; IC95%=2,84-4,41), ICT=0,542 (ORa=3,45; IC95%=2,79-4,27) e IMC=26,7 kg/m2 (ORa=3,25; IC95%=2,64-4,02); y para glucemia elevada CC=93,5 cm (ORa=4,28; IC95%=2,72-6,75), ICT=0,573 (ORa=3,61; IC95%=2,31-5,66) e IMC=27,8 kg/m2 (ORa=3,14; IC95%=2,03-4,87).
+ Conclusion: Los adultos argentinos a quienes se les mida CC sobre la piel y se encuentren por encima de los puntos de corte aqui identificados, cuentan con un riesgo significativamente mayor de presentar tension arterial y glucemia elevadas.
+ Language: Spanish
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.31053%2f1853.0605.v79.n3.37313
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Farinola&issn=0014-6722&title=Revista+de+la+Facultad+de+Ciencias+Medicas+de+Cordoba&atitle=Puntos+de+corte+de+indicadores+antropometricos+para+hipertension+e+hiperglucemia+en+adultos+argentinos&volume=79&issue=3&spage=260&epage=266&date=2022&doi=10.31053%2F1853.0605.v79.n3.37313&pmid=36149065&sid=OVID:medline
+
+<410>
+Unique Identifier
+ 36142750
+Title
+ Brown Adipose Tissue Sheds Extracellular Vesicles That Carry Potential Biomarkers of Metabolic and Thermogenesis Activity Which Are Affected by High Fat Diet Intervention.
+Source
+ International Journal of Molecular Sciences. 23(18), 2022 Sep 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Camino T; Lago-Baameiro N; Sueiro A; Bravo SB; Couto I; Santos FF; Baltar J; Casanueva FF; Pardo M
+Author NameID
+ Bravo, Susana Belen; ORCID: https://orcid.org/0000-0001-7615-3079
+ Couto, Ivan; ORCID: https://orcid.org/0000-0001-8184-654X
+ Casanueva, Felipe F; ORCID: https://orcid.org/0000-0002-9052-8161
+ Pardo, Maria; ORCID: https://orcid.org/0000-0002-9967-1650
+Authors Full Name
+ Camino, Tamara; Lago-Baameiro, Nerea; Sueiro, Aurelio; Bravo, Susana Belen; Couto, Ivan; Santos, Francisco Fernando; Baltar, Javier; Casanueva, Felipe F; Pardo, Maria.
+Institution
+ Camino, Tamara. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Lago-Baameiro, Nerea. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Sueiro, Aurelio. Grupo Endocrinologia Molecular y Celular, Instituto de Investigacion Sanitaria de Santiago (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Bravo, Susana Belen. Unidad de Proteomica, Instituto de Investigacion Sanitaria de Santiago (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Couto, Ivan. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Couto, Ivan. Servicio de Cirugia Plastica y Reparadora, Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Santos, Francisco Fernando. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Santos, Francisco Fernando. Servicio de Cirugia General, Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Baltar, Javier. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Baltar, Javier. CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Casanueva, Felipe F. Grupo Endocrinologia Molecular y Celular, Instituto de Investigacion Sanitaria de Santiago (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Casanueva, Felipe F. CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Pardo, Maria. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.
+ Pardo, Maria. CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, 28029 Madrid, Spain.
+MeSH Subject Headings
+ Adipose Tissue, Brown/me [Metabolism]
+ *Adipose Tissue, Brown
+ Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Ceruloplasmin/me [Metabolism]
+ Diet, High-Fat
+ Energy Metabolism
+ Extracellular Vesicles/me [Metabolism]
+ *Extracellular Vesicles
+ Glucose Transporter Type 1/me [Metabolism]
+ Obesity/me [Metabolism]
+ Proteome/me [Metabolism]
+ Rats
+ Rats, Sprague-Dawley
+ Thermogenesis
+ Uncoupling Protein 1/me [Metabolism]
+Keyword Heading
+ adipose tissue
+ batosomes
+ brown adipose tissue
+ cell communication
+ exosomes
+ extracellular vesicles
+ metabolic diseases
+ obesity
+ proteome
+ white adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Brown adipose tissue (BAT) is a key target for the development of new therapies against obesity due to its role in promoting energy expenditure; BAT secretory capacity is emerging as an important contributor to systemic effects, in which BAT extracellular vesicles (EVs) (i.e., batosomes) might be protagonists. EVs have emerged as a relevant cellular communication system and carriers of disease biomarkers. Therefore, characterization of the protein cargo of batosomes might reveal their potential as biomarkers of the metabolic activity of BAT. In this study, we are the first to isolate batosomes from lean and obese Sprague-Dawley rats, and to establish reference proteome maps. An LC-SWATH/MS analysis was also performed for comparisons with EVs secreted by white adipose tissue (subcutaneous and visceral WAT), and it showed that 60% of proteins were exclusive to BAT EVs. Precisely, batosomes of lean animals contain proteins associated with mitochondria, lipid metabolism, the electron transport chain, and the beta-oxidation pathway, and their protein cargo profile is dramatically affected by high fat diet (HFD) intervention. Thus, in obesity, batosomes are enriched with proteins involved in signal transduction, cell communication, the immune response, inflammation, thermogenesis, and potential obesity biomarkers including UCP1, Glut1, MIF, and ceruloplasmin. In conclusion, the protein cargo of BAT EVs is affected by the metabolic status and contains potential biomarkers of thermogenesis activity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glucose Transporter Type 1). 0 (Proteome). 0 (Uncoupling Protein 1). EC 1-16-3-1 (Ceruloplasmin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms231810826
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Camino&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Brown+Adipose+Tissue+Sheds+Extracellular+Vesicles+That+Carry+Potential+Biomarkers+of+Metabolic+and+Thermogenesis+Activity+Which+Are+Affected+by+High+Fat+Diet+Intervention.&volume=23&issue=18&spage=10826&epage=&date=2022&doi=10.3390%2Fijms231810826&pmid=36142750&sid=OVID:medline
+
+<411>
+Unique Identifier
+ 36142534
+Title
+ Apolipoproteins-New Biomarkers of Overweight and Obesity among Childhood Acute Lymphoblastic Leukemia Survivors?.
+Source
+ International Journal of Molecular Sciences. 23(18), 2022 Sep 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sztolsztener K; Zywno H; Hodun K; Kononczuk K; Muszynska-Roslan K; Latoch E
+Author NameID
+ Sztolsztener, Klaudia; ORCID: https://orcid.org/0000-0003-1354-7585
+ Zywno, Hubert; ORCID: https://orcid.org/0000-0001-8470-0351
+ Hodun, Katarzyna; ORCID: https://orcid.org/0000-0002-2102-7638
+ Kononczuk, Katarzyna; ORCID: https://orcid.org/0000-0003-0540-8040
+ Muszynska-Roslan, Katarzyna; ORCID: https://orcid.org/0000-0001-9551-2145
+ Latoch, Eryk; ORCID: https://orcid.org/0000-0002-7667-7953
+Authors Full Name
+ Sztolsztener, Klaudia; Zywno, Hubert; Hodun, Katarzyna; Kononczuk, Katarzyna; Muszynska-Roslan, Katarzyna; Latoch, Eryk.
+Institution
+ Sztolsztener, Klaudia. Department of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.
+ Zywno, Hubert. Department of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.
+ Hodun, Katarzyna. Department of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.
+ Kononczuk, Katarzyna. Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
+ Muszynska-Roslan, Katarzyna. Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
+ Latoch, Eryk. Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
+MeSH Subject Headings
+ Biomarkers
+ Child
+ Cross-Sectional Studies
+ Humans
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+ *Overweight
+ Precursor Cell Lymphoblastic Leukemia-Lymphoma/co [Complications]
+ Precursor Cell Lymphoblastic Leukemia-Lymphoma/di [Diagnosis]
+ Precursor Cell Lymphoblastic Leukemia-Lymphoma/dt [Drug Therapy]
+ *Precursor Cell Lymphoblastic Leukemia-Lymphoma
+ Survivors
+Keyword Heading
+ apolipoproteins
+ childhood acute lymphoblastic leukemia
+ overweight
+ pediatric cancer
+ survivors
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Patients suffering from childhood acute lymphoblastic leukemia (ALL) are at risk of late adverse treatment-related effects. The examination of targeted biomarkers could be used to improve the diagnosis and prediction of life-threatening ALL sequelae. The purpose of this cross-sectional study was to search for treatment-related alterations in apolipoprotein (Apo) levels as potential markers of the occurrence of obesity in subjects treated for ALL, and to assess the relationships between weight, gender, anticancer treatment, and Apo concentrations. Fifty-eight ALL survivors were included in the study. The mean time of follow-up after treatment cessation was 5.41 +/- 4.29 years. Serum levels of apolipoproteins were measured using a multiplex assay kit. Among ALL survivors, we observed a significant correlation of Apo-C1, Apo-C3, Apo-H, and Apo-J levels, depending on body mass index (BMI). Marked differences were observed in the area under the curve of Apo-A1, Apo-A2, Apo-C1, Apo-D. In our study, patients with a history of childhood ALL developed alterations in their Apo profile. Furthermore, this is the first study revealing that some apolipoproteins may act as valuable biomarkers useful in the prognosis of metabolic imbalance. We believe that this paper, at least partially, will highlight the importance of long-term prognosis of metabolic complications associated with the anticancer chemotherapy used to treat hematological malignancies in children.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms231810634
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sztolsztener&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Apolipoproteins-New+Biomarkers+of+Overweight+and+Obesity+among+Childhood+Acute+Lymphoblastic+Leukemia+Survivors%3F.&volume=23&issue=18&spage=10634&epage=&date=2022&doi=10.3390%2Fijms231810634&pmid=36142534&sid=OVID:medline
+
+<412>
+Unique Identifier
+ 36139454
+Title
+ Dectin-1 as a Potential Inflammatory Biomarker for Metabolic Inflammation in Adipose Tissue of Individuals with Obesity.
+Source
+ Cells. 11(18), 2022 09 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al Madhoun A; Kochumon S; Al-Rashed F; Sindhu S; Thomas R; Miranda L; Al-Mulla F; Ahmad R
+Author NameID
+ Al Madhoun, Ashraf; ORCID: https://orcid.org/0000-0001-8593-3878
+ Al-Rashed, Fatema; ORCID: https://orcid.org/0000-0002-5825-7701
+ Sindhu, Sardar; ORCID: https://orcid.org/0000-0001-9936-1575
+ Al-Mulla, Fahd; ORCID: https://orcid.org/0000-0001-5409-3829
+ Ahmad, Rasheed; ORCID: https://orcid.org/0000-0001-5746-0743
+Authors Full Name
+ Al Madhoun, Ashraf; Kochumon, Shihab; Al-Rashed, Fatema; Sindhu, Sardar; Thomas, Reeby; Miranda, Lavina; Al-Mulla, Fahd; Ahmad, Rasheed.
+Institution
+ Al Madhoun, Ashraf. Animal and Imaging Core Facilities, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Al Madhoun, Ashraf. Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Kochumon, Shihab. Immunology and Microbiology Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Al-Rashed, Fatema. Immunology and Microbiology Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Sindhu, Sardar. Animal and Imaging Core Facilities, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Sindhu, Sardar. Immunology and Microbiology Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Thomas, Reeby. Immunology and Microbiology Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Miranda, Lavina. Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Al-Mulla, Fahd. Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Ahmad, Rasheed. Immunology and Microbiology Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+MeSH Subject Headings
+ Adiponectin/me [Metabolism]
+ *Adiponectin
+ Adipose Tissue/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Chemokine CCL5/me [Metabolism]
+ *Chemokine CCL5
+ Cytokines/me [Metabolism]
+ Humans
+ Inflammation/pa [Pathology]
+ Lectins, C-Type/me [Metabolism]
+ *Lectins, C-Type
+ Lipids
+ Myeloid Differentiation Factor 88/me [Metabolism]
+ Obesity/me [Metabolism]
+ RNA/me [Metabolism]
+ RNA-Directed DNA Polymerase/me [Metabolism]
+ Toll-Like Receptor 2/me [Metabolism]
+Keyword Heading
+ adipose tissue
+ dectin-1
+ metabolic inflammation
+ obesity
+ proinflammatory markers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In obesity, macrophage activation and infiltration in adipose tissue (AT) underlie chronic low-grade inflammation-induced insulin resistance. Although dectin-1 is primarily a pathogen recognition receptor and innate immune response modulator, its role in metabolic syndromes remains to be clarified. This study aimed to investigate the dectin-1 gene expression in subcutaneous AT in the context of obesity and associated inflammatory markers. Subcutaneous AT biopsies were collected from 59 nondiabetic (lean/overweight/obese) individuals. AT gene expression levels of dectin-1 and inflammatory markers were determined via real-time reverse transcriptase-quantitative polymerase chain reaction. Dectin-1 protein expression was assessed using immunohistochemistry. Plasma lipid profiles were measured by ELISA. AT dectin-1 transcripts and proteins were significantly elevated in obese as compared to lean individuals. AT dectin-1 transcripts correlated positively with body mass index and fat percentage (r >= 0.340, p <= 0.017). AT dectin-1 RNA levels correlated positively with clinical parameters, including plasma C-reactive protein and CCL5/RANTES, but negatively with that of adiponectin. The expression of dectin-1 transcripts was associated with that of various proinflammatory cytokines, chemokines, and their cognate receptors (r >= 0.300, p <= 0.05), but not with anti-inflammatory markers. Dectin-1 and members of the TLR signaling cascade were found to be significantly associated, suggesting an interplay between the two pathways. Dectin-1 expression was correlated with monocyte/macrophage markers, including CD16, CD68, CD86, and CD163, suggesting its monocytes/macrophage association in an adipose inflammatory microenvironment. Dectin-1 expression was independently predicted by CCR5, CCL20, TLR2, and MyD88. In conclusion, dectin-1 may be regarded as an AT biomarker of metabolic inflammation in obesity.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (CLEC7A protein, human). 0 (Chemokine CCL5). 0 (Cytokines). 0 (Lectins, C-Type). 0 (Lipids). 0 (Myeloid Differentiation Factor 88). 0 (Toll-Like Receptor 2). 63231-63-0 (RNA). 9007-41-4 (C-Reactive Protein). EC 2-7-7-49 (RNA-Directed DNA Polymerase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fcells11182879
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al+Madhoun&issn=2073-4409&title=Cells&atitle=Dectin-1+as+a+Potential+Inflammatory+Biomarker+for+Metabolic+Inflammation+in+Adipose+Tissue+of+Individuals+with+Obesity.&volume=11&issue=18&spage=&epage=&date=2022&doi=10.3390%2Fcells11182879&pmid=36139454&sid=OVID:medline
+
+<413>
+Unique Identifier
+ 36131504
+Title
+ The effects of consuming a Mediterranean style diet on associated COVID-19 severity biomarkers in obese/overweight adults: A systematic review. [Review]
+Source
+ Nutrition and Health. 28(4):647-667, 2022 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moore E; Fadel A; Lane KE
+Author NameID
+ Lane, Katie E; ORCID: https://orcid.org/0000-0002-9092-2927
+Authors Full Name
+ Moore, Ella; Fadel, Abdulmannan; Lane, Katie E.
+Institution
+ Moore, Ella. Research Institute for Sport and Exercise Science, School of Sport and Exercise Sciences, 4589Liverpool John Moores University, Liverpool, UK.
+ Fadel, Abdulmannan. Research Institute for Sport and Exercise Science, School of Sport and Exercise Sciences, 4589Liverpool John Moores University, Liverpool, UK.
+ Lane, Katie E. Research Institute for Sport and Exercise Science, School of Sport and Exercise Sciences, 4589Liverpool John Moores University, Liverpool, UK.
+MeSH Subject Headings
+ Adult
+ Humans
+ Overweight/ep [Epidemiology]
+ *Diet, Mediterranean
+ COVID-19/ep [Epidemiology]
+ COVID-19/pc [Prevention & Control]
+ *COVID-19
+ Obesity/ep [Epidemiology]
+ Biomarkers
+Keyword Heading
+ BMI
+ COVID-19
+ Mediterranean diet
+ biomarkers
+ hypocaloric diet
+ non-communicable disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: COVID-19 severity is strongly associated with high Body Mass Index (BMI) (>=25kg/m2) amongst adults and elevated inflammatory markers have enabled prediction of disease progression. The composition of a Mediterranean diet provides favourable outcomes on weight reduction and inflammatory markers. Aim: This systematic review aimed to investigate the effects of consuming a Mediterranean diet on BMI and inflammatory markers of obese/overweight adults (>=18 years) at risk of developing severe COVID-19 outcomes. Methods: PubMed Central, Cochrane Library and MEDLINE databases were searched to identify randomised controlled trials published between January 2010 to August 2021 evaluating the impact of Mediterranean diet on BMI and inflammatory markers in overweight/obese adults. The review followed the PRISMA checklist, used Cochrane Collaboration search strategies, and is PROSPERO registered (CRD42021277070). Two authors independently screened and evaluated studies for methodological quality. Papers were extracted and included based eligibility, despite risk of bias scores. Results: Of 65 extracted records, six studies met the eligibility criteria and were included. Reductions in BMI, TNF-alpha, IL-6 and hs-CRP were reported amongst most findings, the majority of which were significant. Conclusion: The main findings indicate a hypocaloric, fibre dense Mediterranean diet is a short-term (<4 months) mitigation strategy to significantly reduce BMI and inflammatory markers amongst overweight/obese adults at risk of developing severe COVID-19 outcomes. Further research is now needed to examine the role of Mediterranean diet in COVID-19 prevalence, severity, morbidity and mortality.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Systematic Review. Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1177%2f02601060221127853
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moore&issn=0260-1060&title=Nutrition+and+Health&atitle=The+effects+of+consuming+a+Mediterranean+style+diet+on+associated+COVID-19+severity+biomarkers+in+obese%2Foverweight+adults%3A+A+systematic+review.&volume=28&issue=4&spage=647&epage=667&date=2022&doi=10.1177%2F02601060221127853&pmid=36131504&sid=OVID:medline
+
+<414>
+Unique Identifier
+ 36127687
+Title
+ The effect of obesity and subsequent weight reduction on cardiac structure and function in dogs.
+Source
+ BMC Veterinary Research [Electronic Resource]. 18(1):351, 2022 Sep 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Partington C; Hodgkiss-Geere H; Woods GRT; Dukes-McEwan J; Flanagan J; Biourge V; German AJ
+Authors Full Name
+ Partington, C; Hodgkiss-Geere, H; Woods, G R T; Dukes-McEwan, J; Flanagan, J; Biourge, V; German, A J.
+Institution
+ Partington, C. Institute of Infection, Veterinary, Ecological and Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Chester High Road, Neston, CH64 7TE, Wirral, UK. cgrp2@cam.ac.uk.
+ Partington, C. Present address: Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK. cgrp2@cam.ac.uk.
+ Hodgkiss-Geere, H. Institute of Infection, Veterinary, Ecological and Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Chester High Road, Neston, CH64 7TE, Wirral, UK.
+ Woods, G R T. Institute of Life Course and Medical Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Chester High Road, Neston, CH64 7TE, Wirral, UK.
+ Dukes-McEwan, J. Institute of Infection, Veterinary, Ecological and Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Chester High Road, Neston, CH64 7TE, Wirral, UK.
+ Flanagan, J. Royal Canin Research Center, 650 Avenue de la petite Camargue - CS10309, 30470, Aimargues, France.
+ Biourge, V. Royal Canin Research Center, 650 Avenue de la petite Camargue - CS10309, 30470, Aimargues, France.
+ German, A J. Institute of Life Course and Medical Sciences, Department of Small Animal Clinical Sciences, Teaching Hospital, University of Liverpool, Chester High Road, Neston, CH64 7TE, Wirral, UK.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cardiomyopathies/pc [Prevention & Control]
+ Cardiomyopathies/ve [Veterinary]
+ *Cardiomyopathies
+ Dog Diseases/pc [Prevention & Control]
+ *Dog Diseases
+ Dogs
+ Obesity/ve [Veterinary]
+ *Obesity
+ Prospective Studies
+ Troponin I
+ Weight Loss/ph [Physiology]
+Keyword Heading
+ Canine
+ Cardiac biomarkers
+ Echocardiography
+ Heart rate variability
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In people, the cardiovascular effects of obesity include systemic hypertension, cardiac remodelling and both systolic and diastolic dysfunction, whilst weight reduction can reverse myocardial remodelling and reduce risk of subsequent cardiovascular disease. To date, variable results are reported in studies of the effect of obesity and controlled weight reduction on cardiovascular morphology and function in dogs. This prospective study aimed to assess cardiac function, heart rate variability, cardiac biomarkers and body composition before and after weight reduction in pet dogs with obesity. Twenty-four client-owned dogs referred for weight management due to obesity were recruited. To assess the cardiac effects of obesity, body composition analysis (by dual energy X-ray absorptiometry, DEXA) and cardiovascular assessment (echocardiography, Doppler blood pressure, electrocardiography, cardiac biomarkers) were performed prior to weight management. Twelve dogs completed the study and reached target weight, receiving a further cardiovascular assessment and DEXA. A Wilcoxon-signed rank test was used to compare each variable pre- and post- weight reduction.
+
+ RESULTS: Median (interquartile range) duration of weight loss was 224 days (124-245 days), percentage weight loss was 23% (18-31%) of starting weight. Median change in body fat mass was -50% (-44% to -55%; P = 0.004), whilst median change in lean mass was -7% (+ 1% to -18%, P = 0.083). Before weight reduction, diastolic dysfunction (evidence of impaired relaxation in all dogs), increased left ventricular wall thickness and mildly elevated systolic blood pressure (14/24 >= 160 mmHg, median 165 mmHg (140-183)) were common features in dogs with obesity. However, systolic left ventricular wall dimensions were the only variables that changed after weight reduction, with a decrease in both the systolic interventricular septum (P = 0.029) and systolic left ventricular free wall (P = 0.017). There was no evidence of decreased heart rate variability in dogs with obesity (P = 0.367), and no change in cardiac biomarker concentrations with weight reduction (N-terminal proBNP, P = 0.262; cardiac troponin I P = 0.657).
+
+ CONCLUSIONS: Canine obesity results in diastolic dysfunction and left ventricular hypertrophy, the latter of which improves with significant weight and fat mass reduction. Further studies are required to clarify the clinical consequences of these findings. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Troponin I).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12917-022-03449-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Partington&issn=1746-6148&title=BMC+Veterinary+Research+%5BElectronic+Resource%5D&atitle=The+effect+of+obesity+and+subsequent+weight+reduction+on+cardiac+structure+and+function+in+dogs.&volume=18&issue=1&spage=351&epage=&date=2022&doi=10.1186%2Fs12917-022-03449-4&pmid=36127687&sid=OVID:medline
+
+<415>
+Unique Identifier
+ 36115281
+Title
+ Impact of duodenal-jejunal bypass liner (DJBL) on NAFLD in patients with obesity and type 2 diabetes mellitus.
+Source
+ Nutrition. 103-104:111806, 2022 Nov-Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Roehlen N; Laubner K; Nicolaus L; Schwacha H; Bettinger D; Krebs A; Thimme R; Seufert J
+Authors Full Name
+ Roehlen, Natascha; Laubner, Katharina; Nicolaus, Leonard; Schwacha, Henning; Bettinger, Dominik; Krebs, Andreas; Thimme, Robert; Seufert, Jochen.
+Institution
+ Roehlen, Natascha. Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Berta-Ottenstein Program, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Division of Hepatology, Gastroenterology and Gastrointestinal Endoscopy, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
+ Laubner, Katharina. Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address: Katharina.laubner@uniklinik-freiburg.de.
+ Nicolaus, Leonard. Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
+ Schwacha, Henning. Division of Hepatology, Gastroenterology and Gastrointestinal Endoscopy, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
+ Bettinger, Dominik. Division of Hepatology, Gastroenterology and Gastrointestinal Endoscopy, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
+ Krebs, Andreas. Centre of Laboratory Diagnostics, MVZ Clotten, Freiburg im Breisgau, Germany.
+ Thimme, Robert. Division of Hepatology, Gastroenterology and Gastrointestinal Endoscopy, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
+ Seufert, Jochen. Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/su [Surgery]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ *Bariatric Surgery
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/su [Surgery]
+ *Non-alcoholic Fatty Liver Disease
+ Duodenum/su [Surgery]
+ Duodenum/me [Metabolism]
+ Jejunum/su [Surgery]
+ Jejunum/me [Metabolism]
+ Treatment Outcome
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+ Obesity/me [Metabolism]
+ Biomarkers
+ Fibrosis
+Keyword Heading
+ Endoscopy, DJBL
+ Metabolic syndrome
+ NASH
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) represents an excessively rising entity of chronic liver disease and is a leading cause of mortality among patients with metabolic syndrome. The duodenal-jejunal bypass liner (DJBL) is a minimally invasive endoscopic treatment option for patients with obesity and type 2 diabetes (T2DM). Although beneficial effects of DJBL therapy on body weight reduction and glycemic control have been described, the effects of DJBL implantation on NAFLD is unknown. The aim of this study was to to evaluate the effects of DJBL implantation for 6 to 9 months on biochemical and clinical biomarkers of NAFLD in a large cohort of patients.
+
+ METHODS: The effect of DJBL treatment on biochemical and clinical parameters of NAFLD were assessed in a study cohort of 71 patients with obesity and T2DM. DJBL was implanted for 9 to 12 months and patients were regularly monitored during the implantation period and for a follow-up period of 6 months after explantation.
+
+ RESULTS: DJBL therapy was associated with a significant decrease in fatty liver index during time of implantation (explantation versus implantation: 93.38 versus 98.22, P < 0.001). Moreover, DJBL implantation was associated with decreases of alanine aminotransferase (29.03 versus 42.29 U/L, P < 0.0001) and cytokeratin-18 fragments (CK18 MF30; 190.6 versus 276 U/L, P < 0.0001), that further remained stable during 6 months after explantation. NAFLD fibrosis and aspartate aminotransferase-to-platelet ratio index (APRI) scores decreased significantly during implantation (-0.83 versus 0.19, P < 0.001, 0.26 versus 0.36, P < 0.0001, respectively).
+
+ CONCLUSIONS: To our knowledge, this is the first study to demonstrate significant effects of DJBL treatment on biochemical and clinical markers of NAFLD activity. Significant effects of DJBL treatment on NAFLD fibrosis and APRI score further suggests protective effects of DJBL on liver-related morbidity and mortality in patients with obesity and T2DM. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.nut.2022.111806
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Roehlen&issn=0899-9007&title=Nutrition&atitle=Impact+of+duodenal-jejunal+bypass+liner+%28DJBL%29+on+NAFLD+in+patients+with+obesity+and+type+2+diabetes+mellitus.&volume=103-104&issue=&spage=111806&epage=&date=2022&doi=10.1016%2Fj.nut.2022.111806&pmid=36115281&sid=OVID:medline
+
+<416>
+Unique Identifier
+ 36104384
+Title
+ Association between anthropometric markers of adiposity, adipokines and vitamin D levels.
+Source
+ Scientific Reports. 12(1):15435, 2022 09 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Patriota P; Rezzi S; Guessous I; Marques-Vidal P
+Author NameID
+ Patriota, Pollyanna; ORCID: https://orcid.org/0000-0003-0853-1458
+ Rezzi, Serge; ORCID: https://orcid.org/0000-0002-0691-2153
+ Guessous, Idris; ORCID: https://orcid.org/0000-0002-0491-6089
+ Marques-Vidal, Pedro; ORCID: https://orcid.org/0000-0002-4548-8500
+Authors Full Name
+ Patriota, Pollyanna; Rezzi, Serge; Guessous, Idris; Marques-Vidal, Pedro.
+Institution
+ Patriota, Pollyanna. Swiss Nutrition and Health Foundation, 1066, Epalinges, Switzerland.
+ Rezzi, Serge. Swiss Nutrition and Health Foundation, 1066, Epalinges, Switzerland.
+ Guessous, Idris. Division of Primary Care Medicine, Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.
+ Marques-Vidal, Pedro. Department of Medicine, Internal Medicine, Lausanne University Hospital, University of Lausanne, Office BH10-642, 46 Rue du Bugnon 46, 1011, Lausanne, Switzerland. Pedro-Manuel.Marques-Vidal@chuv.ch.
+MeSH Subject Headings
+ Adipokines
+ *Adiposity
+ Biomarkers
+ Cross-Sectional Studies
+ Female
+ Humans
+ Male
+ Obesity
+ Vitamin D
+ Vitamin D Deficiency/co [Complications]
+ *Vitamin D Deficiency
+ Vitamins
+Abstract
+ Inverse association between serum levels of vitamin D and obesity has been pointed out in several studies. Our aim was to identify to the associations between vitamin D levels and a large panel of anthropometric markers and adipokines. Cross-sectional study including 6485 participants. Anthropometric markers included body mass index (BMI), % body fat, waist, waist-to-hip (WHR), waist-to-height (WHtR), conicity index, body roundness index (BRI) and a body shape index (ABSI). 55.7% of women and 60.1% of men presented with vitamin D deficiency. Vitamin D levels were negatively associated with most anthropometric markers, with correlation coefficients ranging between -0.017 (ABSI) and -0.192 (BMI) in women and between -0.026 (weight) and -0.130 (% body fat) in men. Vitamin D levels were inversely associated with leptin levels in both sexes and positively associated with adiponectin levels in women only. The likelihood of vitamin D deficiency increased with increasing adiposity levels, except for ABSI (women) and BMI (men). Total body fat, rather than localized or unevenly distributed body fat, is the adiposity marker most associated with decreased vitamin D levels. Monitoring vitamin D levels in people with overweight/obesity is essential. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Vitamins). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41598-022-19409-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Patriota&issn=2045-2322&title=Scientific+Reports&atitle=Association+between+anthropometric+markers+of+adiposity%2C+adipokines+and+vitamin+D+levels.&volume=12&issue=1&spage=15435&epage=&date=2022&doi=10.1038%2Fs41598-022-19409-9&pmid=36104384&sid=OVID:medline
+
+<417>
+Unique Identifier
+ 36099423
+Title
+ Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients.
+Source
+ Cancer Epidemiology, Biomarkers & Prevention. 31(12):2148-2156, 2022 12 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Himbert C; Warby CA; Gigic B; Ose J; Lin T; Viskochil R; Peoples AR; Ashworth A; Schrotz-King P; Scaife CL; Cohan JN; Jedrzkiewicz J; Schirmacher P; Grady WM; Cohen SA; Krane M; Figueiredo JC; Toriola AT; Siegel EM; Shibata D; Round JL; Huang LC; Li CI; Schneider M; Ulrich A; Hardikar S; Ulrich CM
+Author NameID
+ Himbert, Caroline; ORCID: https://orcid.org/0000-0003-4084-8340
+ Warby, Christy A; ORCID: https://orcid.org/0000-0003-1772-8332
+ Gigic, Biljana; ORCID: https://orcid.org/0000-0002-8085-2072
+ Ose, Jennifer; ORCID: https://orcid.org/0000-0002-2030-9676
+ Lin, Tengda; ORCID: https://orcid.org/0000-0001-5147-8432
+ Viskochil, Richard; ORCID: https://orcid.org/0000-0001-7167-174X
+ Peoples, Anita R; ORCID: https://orcid.org/0000-0003-3645-3960
+ Ashworth, Anjelica; ORCID: https://orcid.org/0000-0002-9676-7702
+ Schrotz-King, Petra; ORCID: https://orcid.org/0000-0003-4339-3492
+ Scaife, Courtney L; ORCID: https://orcid.org/0000-0003-2497-4961
+ Cohan, Jessica N; ORCID: https://orcid.org/0000-0002-5461-4716
+ Jedrzkiewicz, Jolanta; ORCID: https://orcid.org/0000-0002-9408-3139
+ Schirmacher, Peter; ORCID: https://orcid.org/0000-0002-0950-3339
+ Grady, William M; ORCID: https://orcid.org/0000-0002-0129-7809
+ Cohen, Stacey A; ORCID: https://orcid.org/0000-0002-6207-9856
+ Krane, Mukta; ORCID: https://orcid.org/0000-0003-4872-1061
+ Figueiredo, Jane C; ORCID: https://orcid.org/0000-0001-8040-3341
+ Toriola, Adetunji T; ORCID: https://orcid.org/0000-0003-1079-2606
+ Siegel, Erin M; ORCID: https://orcid.org/0000-0003-1779-2510
+ Shibata, David; ORCID: https://orcid.org/0000-0002-5670-423X
+ Round, June L; ORCID: https://orcid.org/0000-0002-7158-9874
+ Huang, Lyen C; ORCID: https://orcid.org/0000-0002-8605-2631
+ Li, Christopher I; ORCID: https://orcid.org/0000-0003-1543-0743
+ Schneider, Martin; ORCID: https://orcid.org/0000-0001-8215-7359
+ Ulrich, Alexis; ORCID: https://orcid.org/0000-0003-1469-2186
+ Hardikar, Sheetal; ORCID: https://orcid.org/0000-0003-0292-6168
+ Ulrich, Cornelia M; ORCID: https://orcid.org/0000-0001-7641-059X
+Authors Full Name
+ Himbert, Caroline; Warby, Christy A; Gigic, Biljana; Ose, Jennifer; Lin, Tengda; Viskochil, Richard; Peoples, Anita R; Ashworth, Anjelica; Schrotz-King, Petra; Scaife, Courtney L; Cohan, Jessica N; Jedrzkiewicz, Jolanta; Schirmacher, Peter; Grady, William M; Cohen, Stacey A; Krane, Mukta; Figueiredo, Jane C; Toriola, Adetunji T; Siegel, Erin M; Shibata, David; Round, June L; Huang, Lyen C; Li, Christopher I; Schneider, Martin; Ulrich, Alexis; Hardikar, Sheetal; Ulrich, Cornelia M.
+Institution
+ Himbert, Caroline. University of Utah, Salt Lake City, Utah.
+ Himbert, Caroline. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Warby, Christy A. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Gigic, Biljana. Heidelberg University Hospital, Heidelberg, Germany.
+ Ose, Jennifer. University of Utah, Salt Lake City, Utah.
+ Ose, Jennifer. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Lin, Tengda. University of Utah, Salt Lake City, Utah.
+ Lin, Tengda. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Viskochil, Richard. University of Massachusetts Boston, Boston, Massachusetts.
+ Peoples, Anita R. University of Utah, Salt Lake City, Utah.
+ Peoples, Anita R. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Ashworth, Anjelica. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Schrotz-King, Petra. Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Germany.
+ Scaife, Courtney L. University of Utah, Salt Lake City, Utah.
+ Scaife, Courtney L. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Cohan, Jessica N. University of Utah, Salt Lake City, Utah.
+ Cohan, Jessica N. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Jedrzkiewicz, Jolanta. University of Utah, Salt Lake City, Utah.
+ Jedrzkiewicz, Jolanta. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Schirmacher, Peter. Heidelberg University Hospital, Heidelberg, Germany.
+ Grady, William M. Fred Hutchinson Cancer Center, Seattle, Washington.
+ Grady, William M. University of Washington School of Medicine, Seattle, Washington.
+ Cohen, Stacey A. Fred Hutchinson Cancer Center, Seattle, Washington.
+ Cohen, Stacey A. University of Washington School of Medicine, Seattle, Washington.
+ Krane, Mukta. Fred Hutchinson Cancer Center, Seattle, Washington.
+ Krane, Mukta. University of Washington School of Medicine, Seattle, Washington.
+ Figueiredo, Jane C. Cedars-Sinai Medical Center, Los Angeles, California.
+ Toriola, Adetunji T. Washington University School of Medicine, St. Louis, Missouri.
+ Siegel, Erin M. H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
+ Shibata, David. University of Tennessee Health Science Center, Memphis, Tennessee.
+ Round, June L. University of Utah, Salt Lake City, Utah.
+ Huang, Lyen C. University of Utah, Salt Lake City, Utah.
+ Huang, Lyen C. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Li, Christopher I. Fred Hutchinson Cancer Center, Seattle, Washington.
+ Li, Christopher I. University of Washington School of Medicine, Seattle, Washington.
+ Schneider, Martin. Heidelberg University Hospital, Heidelberg, Germany.
+ Ulrich, Alexis. Rheinland Klinikum Neuss Lukas Krankenhaus, Neuss, Germany.
+ Hardikar, Sheetal. University of Utah, Salt Lake City, Utah.
+ Hardikar, Sheetal. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Ulrich, Cornelia M. University of Utah, Salt Lake City, Utah.
+ Ulrich, Cornelia M. Huntsman Cancer Institute, Salt Lake City, Utah.
+MeSH Subject Headings
+ Humans
+ Body Mass Index
+ Overweight/co [Complications]
+ *Overweight
+ Tumor Necrosis Factor-alpha
+ Interleukin-6
+ Obesity
+ Exercise
+ Biomarkers
+ C-Reactive Protein/me [Metabolism]
+ Inflammation
+ *Colorectal Neoplasms
+Abstract
+ BACKGROUND: Physical activity and obesity are well-established factors of colorectal cancer risk and prognosis. Here, we investigate associations of individual and combined physical activity and body mass index (BMI) groups with proinflammatory biomarkers in colorectal cancer patients.
+
+ METHODS: Self-reported physical activity levels were classified as "active" (>=8.75 MET-hours/week) versus "inactive" (<8.75 MET-hours/week) in n = 579 stage I-IV colorectal cancer patients enrolled in the ColoCare Study. BMI [normal weight (>=18.5-<25 kg/m2), overweight (>=25-<30 kg/m2), and obese (>=30 kg/m2)] was abstracted from medical records. Patients were classified into four combinations of physical activity levels and BMI. Biomarkers [C-reactive protein (CRP), SAA, IL6, IL8, and TNFalpha] in presurgery serum samples were measured using the Mesoscale Discovery Platform. Regression models were used to compute relative percent differences in biomarker levels by physical activity and BMI groups.
+
+ RESULTS: "Inactive" patients had non-statistically significant higher IL6 levels compared with "active" patients (+36%, P = 0.10). "Obese" patients had 88% and 17% higher CRP and TNFalpha levels compared with "normal weight" patients (P = 0.03 and 0.02, respectively). Highest CRP levels were observed among "overweight or obese/inactive" compared with "normal weight/active" patients (P = 0.03).
+
+ CONCLUSIONS: We provide evidence of associations between individual and combined physical activity and BMI groups with proinflammatory biomarkers. Although BMI was identified as the key driver of inflammation, biomarker levels were higher among "inactive" patients across BMI groups.
+
+ IMPACT: This is the largest study in colorectal cancer patients investigating associations of energy balance components with inflammatory biomarkers. Our results suggest that physical activity may reduce obesity-induced inflammation in colorectal cancer patients and support the design of randomized controlled trials testing this hypothesis. Copyright ©2022 American Association for Cancer Research.
+Registry Number/Name of Substance
+ 0 (Tumor Necrosis Factor-alpha). 0 (Interleukin-6). 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1158%2f1055-9965.EPI-22-0681
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Himbert&issn=1055-9965&title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&atitle=Associations+of+Individual+and+Combined+Physical+Activity+and+Body+Mass+Index+Groups+with+Proinflammatory+Biomarkers+among+Colorectal+Cancer+Patients.&volume=31&issue=12&spage=2148&epage=2156&date=2022&doi=10.1158%2F1055-9965.EPI-22-0681&pmid=36099423&sid=OVID:medline
+
+<418>
+Unique Identifier
+ 36099346
+Title
+ Ferritin as a predictive biomarker of severity in Covid-19.
+Original Title
+ La ferritine comme biomarqueur predictif des formes severes de Covid-19
+Source
+ Annales de Biologie Clinique. 80(4):363-368, 2022 07 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Perottet J; Gondolf C; Grandhomme F; Creveuil C; Allouche S
+Authors Full Name
+ Perottet, Jeremy; Gondolf, Clementine; Grandhomme, Frederique; Creveuil, Christian; Allouche, Stephane.
+Institution
+ Perottet, Jeremy. Department of Biochemistry, University Hospital of Caen, Caen, France
+ Gondolf, Clementine. Department of Biochemistry, University Hospital of Caen, Caen, France
+ Grandhomme, Frederique. Department of Biochemistry, University Hospital of Caen, Caen, France
+ Creveuil, Christian. Department of Biostatistics and Clinical Research, University Hospital of Caen, Caen, France
+ Allouche, Stephane. Department of Biochemistry, University Hospital of Caen, Caen, France
+ Allouche, Stephane. Signalisation, Electrophysiologie et Imagerie des Lesions d'Ischemie-Reperfusion Myocardique EA4650. Normandie Univ. UNICAEN, Caen, France
+MeSH Subject Headings
+ Biomarkers
+ COVID-19/di [Diagnosis]
+ COVID-19/ep [Epidemiology]
+ *COVID-19
+ *Ferritins
+ Humans
+ Obesity
+ Retrospective Studies
+Keyword Heading
+ ferritin
+ CRP
+ obesity
+ Covid-19
+ predictive markers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: To prevent the crisis-level shortage of beds in hospitals and for a more efficient support, it's necessary to early identify coronavirus disease-19 (Covid-19) patients at risk to develop a severe form of the disease.
+
+ Objective: The goal of our study was to determine whether biological markers, including the serum ferritin, could predict the severity of the Covid-19.
+
+ Methods: One hundred and seventy-one patients, who were admitted to Caen University Hospital, were included retrospectively with a positive diagnosis of Covid-19 by RT-PCR. A serum ferritin measurement was performed for all patients. They were further classified either into a non-severe or a severe group based on their hospitalization in intense care unit (ICU) for mechanical ventilation or death.
+
+ Results: Univariate analysis revealed a significant association between increased serum ferritin and CRP levels, obesity, CT scan lesions, pathological respiratory rate, decreased PaO2/FiO2 ratio, the NEWS-2 score and the severe (n = 59) vs the non-severe (n = 112) outcome of Covid-19 patients. However, in a multivariate analysis, only CRP and obesity were associated with the severe form of Covid-19.
+
+ Conclusion: While pathological level of serum ferritin at admission is associated with severe form of Covid-19, combination of increased CRP level and obesity would better predict the severity of the disease.
+Other Abstract
+ Publisher
+ Pour une meilleure prise en charge, il est necessaire de pouvoir identifier precocement les patients atteints de la Covid-19 susceptibles de developper une forme severe. L'objectif de notre etude etait de determiner si des marqueurs biologiques, notamment la ferritinemie, peuvent predire la severite de la Covid-19. Nous avons inclus de maniere retrospective 171 patients au CHU de Caen avec un diagnostic de Covid-19. Les patients devaient avoir un bilan biologique incluant la ferritinemie a l'admission et ont ete classes en formes severes (n = 59, hospitalisation et ventilation invasive en soins intensifs ou en reanimation, et/ou deces) et non-severes (n = 112, tous les autres patients). L'analyse univariee a montre une association entre les formes severes de Covid-19 avec les niveaux eleves de ferritine et de CRP, l'obesite, les lesions pulmonaires, la frequence respiratoire elevee, la diminution du ratio PaO2/FiO2 et le score de NEWS-2. Cependant, en analyse multivariee seules la CRP et l'obesite montraient une association avec les formes severes. En conclusion, alors que la ferritinemie elevee est associee a un risque accru de developper une forme severe de la Covid-19, la CRP et la presence d'une obesite seraient de meilleurs marqueurs predictifs.
+ Language: French
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-73-2 (Ferritins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1684%2fabc.2022.1725
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Perottet&issn=0003-3898&title=Annales+de+Biologie+Clinique&atitle=La+ferritine+comme+biomarqueur+predictif+des+formes+severes+de+Covid-19&volume=80&issue=4&spage=363&epage=368&date=2022&doi=10.1684%2Fabc.2022.1725&pmid=36099346&sid=OVID:medline
+
+<419>
+Unique Identifier
+ 36092166
+Title
+ Effects of Antioxidant Supplementation on Metabolic Disorders in Obese Patients from Randomized Clinical Controls: A Meta-Analysis and Systematic Review.
+Source
+ Oxidative medicine & cellular longevity. 2022:7255413, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang J; Liao B; Wang C; Zhong O; Lei X; Yang Y
+Author NameID
+ Lei, Xiaocan; ORCID: https://orcid.org/0000-0001-7666-5082
+ Yang, Yuli; ORCID: https://orcid.org/0000-0002-6275-7151
+Authors Full Name
+ Wang, Jinyuan; Liao, Biyun; Wang, Changsheng; Zhong, Ou; Lei, Xiaocan; Yang, Yuli.
+Institution
+ Wang, Jinyuan. Hengyang Maternal and Childe Health Hospital, Hengyang, Hunan 421001, China.
+ Wang, Jinyuan. Clinical Antatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyan, Hunan 421001, China.
+ Liao, Biyun. Reproductive Medicine Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
+ Wang, Changsheng. Clinical Antatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyan, Hunan 421001, China.
+ Zhong, Ou. Clinical Antatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyan, Hunan 421001, China.
+ Lei, Xiaocan. Hengyang Maternal and Childe Health Hospital, Hengyang, Hunan 421001, China.
+ Lei, Xiaocan. Clinical Antatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyan, Hunan 421001, China.
+ Yang, Yuli. Hengyang Maternal and Childe Health Hospital, Hengyang, Hunan 421001, China.
+MeSH Subject Headings
+ Antioxidants/tu [Therapeutic Use]
+ *Antioxidants
+ Biomarkers
+ Dietary Supplements
+ Humans
+ Metabolic Diseases/me [Metabolism]
+ *Metabolic Diseases
+ Obesity/co [Complications]
+ Obesity/dt [Drug Therapy]
+ Randomized Controlled Trials as Topic
+Abstract
+ Purpose: This systematic review and meta-analysis aim at elucidating the heterogeneity in beneficial effects of antioxidant supplementation in obese adults by exploring the differential effects of antioxidant supplementation on basic indicators of obesity, lipid metabolism, systemic antioxidant capacity, inflammatory biomarkers, and liver function.
+
+ Methods: The inclusion criteria specified randomized controlled trials with antioxidant intervention for adults (mean body mass index (BMI) > 30), from inception to Aug. 8, 2021, in the PubMed, Embase, The Cochrane Library, Web of Science, and Scopus databases. Meta-analysis and publication bias were performed using RevMan 5.4 software. Stata16 software was used to detect publication bias with Egger's and Begg's methods being mainly used. The data of basic indicators of obesity, lipid metabolism index, oxidative stress index, inflammatory biomarkers, and liver function index were collected to analyze the beneficial effects of antioxidant supplementation in obese patients.
+
+ Results: A total of 30 studies were included in this study with a sample of 845 obese patients from the antioxidant supplementation group and 766 obese patients from the placebo control group. The meta-analysis showed that obese patients with antioxidant supplementation had lower BMI (mean difference (MD): - 0.44 [95%confidence interval (CI): - 0.84, -0.04], p = 0.03), waist circumference (MD : -0.78 [95%CI:-1.45, -0.11], p = 0.02), fasting blood glucose (FBG) level (standardized mean difference (SMD): - 4.92 [95%CI:-6.87, -2.98], p < 0.001) and homeostasis model assessment of insulin resistance (MD : -0.45 [95%CI:-0.61, -0.3], p < 0.001) when compared to the placebo group. Obese patients on antioxidant supplementation had lower levels of total cholesterol (SMD : -0.43 [95%CI:-0.84, -0.02], p = 0.04), triglycerides (SMD : -0.17 [95%CI:-0.31, -0.04], p = 0.01), low-density lipoprotein (SMD : -0.15 [95%CI:-0.29, -0.01], p = 0.03), malondialdehyde (SMD : -1.67 [95%CI:-2.69, -0.65], p = 0.001), and tumor necrosis factor-alpha (SMD : -0.29 [95%CI:-0.56, -0.02], p = 0.03), respectively, when compared to the placebo group. In addition, obese patients with antioxidant supplementation had higher levels of high-density lipoprotein (SMD : 0.25 [95%CI : 0.03, 0.46], p = 0.03) and superoxide dismutase (SMD : 1.09 [95%CI : 0.52, 1.65], p < 0.001) when compared to the placebo group. Antioxidant supplementation had no effects on other analyzed parameters including waist-hip ratio, leptin, fat mass, interleukin-6, C-reactive protein, alanine transaminase, and aspartate transaminase in obese patients.
+
+ Conclusion: The meta-analysis results indicated that antioxidant supplementation exerted potential beneficial effects in obese patients by regulating FBG, oxidative stress, and inflammation, whilst more high-quality studies are required to confirm these effects. The present study may provide important insights for the treatment of clinical obesity and obesity-associated complications. Copyright © 2022 Jinyuan Wang et al.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1155%2f2022%2f7255413
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1942-0994&title=Oxidative+medicine+%26+cellular+longevity&atitle=Effects+of+Antioxidant+Supplementation+on+Metabolic+Disorders+in+Obese+Patients+from+Randomized+Clinical+Controls%3A+A+Meta-Analysis+and+Systematic+Review.&volume=2022&issue=&spage=7255413&epage=&date=2022&doi=10.1155%2F2022%2F7255413&pmid=36092166&sid=OVID:medline
+
+<420>
+Unique Identifier
+ 36089507
+Title
+ Effect of dietary approaches to stop hypertension (DASH) diet, high in animal or plant protein on cardiometabolic risk factors in obese metabolic syndrome patients: A randomized clinical trial.
+Source
+ Primary care diabetes. 16(5):634-639, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vasei MH; Hosseinpour-Niazi S; Ainy E; Mirmiran P
+Authors Full Name
+ Vasei, Mohamad-Hassan; Hosseinpour-Niazi, Somayeh; Ainy, Elaheh; Mirmiran, Parvin.
+Institution
+ Vasei, Mohamad-Hassan. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Hosseinpour-Niazi, Somayeh. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Ainy, Elaheh. Department of Vice Chancellor Research Affairs, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Mirmiran, Parvin. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mirmiran@endocrine.ac.ir.
+MeSH Subject Headings
+ Animals
+ Humans
+ Biomarkers
+ Blood Glucose
+ Blood Proteins
+ Cardiometabolic Risk Factors
+ Cholesterol, LDL
+ Diet
+ *Dietary Approaches To Stop Hypertension
+ Hypertension/di [Diagnosis]
+ *Hypertension
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/pc [Prevention & Control]
+ *Metabolic Syndrome
+ Obesity/di [Diagnosis]
+ Plant Proteins
+ Triglycerides
+ Adult
+ Middle Aged
+ Aged
+Keyword Heading
+ Animal protein
+ Cardiometabolic risk factors
+ DASH diet
+ Plant protein
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: This study aimed to investigate the effect of replacing plant proteins with animal proteins in the dietary approaches to stop hypertension (DASH) diet on cardiometabolic risk factors in obese metabolic syndrome participants.
+
+ METHODS: In this double-blind randomized controlled clinical trial, 90 obese patients with metabolic syndrome, aged 30-70 years were randomly allocated into the DASH diet based on plant or animal proteins for 8 weeks. Fasting blood samples were collected to assess the biochemical markers. Also, blood pressure, weight, and waist circumference (WC) were measured at the beginning and end of the trial.
+
+ RESULTS: The participants in both groups experienced significant reductions in the fasting plasma glucose (FPG), systolic blood pressure (SBP) and diastolic blood pressure (DBP), triglyceride (TG) concentrations, weight and WC. However the reduction in FPG and SBP was higher in the plant-based DASH group, compared to the animal-based DASH group, after adjustment for weight change. No significant changes were found within or between groups with regard to total cholesterol, LDL-C, HDL-C.
+
+ CONCLUSIONS: Substituting plant proteins with animal proteins in the DASH diet improves FPG and SBP in obese individuals with metabolic syndrome, independent of weight change. IRCT registration number: IRCT20090203001640N16. Copyright © 2022 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Blood Proteins). 0 (Cholesterol, LDL). 0 (Plant Proteins). 0 (Triglycerides).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.pcd.2022.09.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vasei&issn=1878-0210&title=Primary+care+diabetes&atitle=Effect+of+dietary+approaches+to+stop+hypertension+%28DASH%29+diet%2C+high+in+animal+or+plant+protein+on+cardiometabolic+risk+factors+in+obese+metabolic+syndrome+patients%3A+A+randomized+clinical+trial.&volume=16&issue=5&spage=634&epage=639&date=2022&doi=10.1016%2Fj.pcd.2022.09.001&pmid=36089507&sid=OVID:medline
+
+<421>
+Unique Identifier
+ 36088460
+Title
+ Acute sleep loss increases CNS health biomarkers and compromises the ability to stay awake in a sex-and weight-specific manner.
+Source
+ Transl Psychiatry Psychiatry. 12(1):379, 2022 09 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van Egmond LT; Bukhari S; Benedet AL; Ashton NJ; Meth EMS; Boukas A; Engstrom J; Ilemosoglou M; Blennow K; Zetterberg H; Benedict C
+Author NameID
+ van Egmond, Lieve T; ORCID: https://orcid.org/0000-0002-3271-8530
+ Bukhari, Shervin; ORCID: https://orcid.org/0000-0001-8568-1762
+ Blennow, Kaj; ORCID: https://orcid.org/0000-0002-1890-4193
+ Zetterberg, Henrik; ORCID: https://orcid.org/0000-0003-3930-4354
+ Benedict, Christian; ORCID: https://orcid.org/0000-0002-8911-4068
+Authors Full Name
+ van Egmond, Lieve T; Bukhari, Shervin; Benedet, Andrea Lessa; Ashton, Nicholas J; Meth, Elisa M S; Boukas, Alexander; Engstrom, Joachim; Ilemosoglou, Maria; Blennow, Kaj; Zetterberg, Henrik; Benedict, Christian.
+Institution
+ van Egmond, Lieve T. Department of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden. Lieve.van.egmond@neuro.uu.se.
+ van Egmond, Lieve T. Department of Pharmaceutical Biosciences, Molecular Neuropharmacology (Sleep Science Laboratory), Uppsala University, Uppsala, Sweden. Lieve.van.egmond@neuro.uu.se.
+ Bukhari, Shervin. Department of Pharmaceutical Biosciences, Molecular Neuropharmacology (Sleep Science Laboratory), Uppsala University, Uppsala, Sweden.
+ Benedet, Andrea Lessa. Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden.
+ Benedet, Andrea Lessa. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden.
+ Ashton, Nicholas J. Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden.
+ Ashton, Nicholas J. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden.
+ Meth, Elisa M S. Department of Pharmaceutical Biosciences, Molecular Neuropharmacology (Sleep Science Laboratory), Uppsala University, Uppsala, Sweden.
+ Boukas, Alexander. Department of Pharmaceutical Biosciences, Molecular Neuropharmacology (Sleep Science Laboratory), Uppsala University, Uppsala, Sweden.
+ Engstrom, Joachim. Department of Pharmaceutical Biosciences, Molecular Neuropharmacology (Sleep Science Laboratory), Uppsala University, Uppsala, Sweden.
+ Ilemosoglou, Maria. Department of Pharmaceutical Biosciences, Molecular Neuropharmacology (Sleep Science Laboratory), Uppsala University, Uppsala, Sweden.
+ Blennow, Kaj. Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden.
+ Blennow, Kaj. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden.
+ Zetterberg, Henrik. Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden.
+ Zetterberg, Henrik. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden.
+ Zetterberg, Henrik. Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
+ Zetterberg, Henrik. Dementia Research Institute at UCL, London, UK.
+ Zetterberg, Henrik. Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
+ Benedict, Christian. Department of Pharmaceutical Biosciences, Molecular Neuropharmacology (Sleep Science Laboratory), Uppsala University, Uppsala, Sweden.
+MeSH Subject Headings
+ Biomarkers
+ Central Nervous System
+ Female
+ Humans
+ Male
+ Obesity
+ Sleep/ph [Physiology]
+ *Sleep Initiation and Maintenance Disorders
+ *Wakefulness
+ Work Schedule Tolerance/ph [Physiology]
+Abstract
+ Night shift work impairs vigilance performance, reduces the ability to stay awake, and compromises brain health. To investigate if the magnitude of these adverse night shift work effects differs between sexes and weight groups, 47 men and women with either normal weight or obesity participated in one night of sleep and one night of total sleep loss. During the night of sleep loss, participants' subjective sleepiness, vigilance performance, and ability to stay awake during 2-min quiet wake with eyes closed were repeatedly assessed. In addition, blood was collected in the morning after sleep loss and sleep to measure central nervous system (CNS) health biomarkers. Our analysis showed that women were sleepier during the night of sleep loss (P < 0.05) and spent more time in microsleep during quiet wake testing (P < 0.05). Finally, higher blood levels of neurofilament light chain, a biomarker of axonal damage, were found among women in the morning after sleep loss (P < 0.002). Compared with normal-weight subjects, those with obesity were more prone to fall asleep during quiet wake (P < 0.05) and exhibited higher blood levels of the CNS health biomarker pTau181 following sleep loss (P = 0.001). Finally, no differences in vigilance performance were noted between the sex and weight groups. Our findings suggest that the ability to stay awake during and the CNS health biomarker response to night shift work may differ between sexes and weight groups. Follow-up studies must confirm our findings under more long-term night shift work conditions. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41398-022-02146-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+Egmond&issn=2158-3188&title=Transl+Psychiatry+Psychiatry&atitle=Acute+sleep+loss+increases+CNS+health+biomarkers+and+compromises+the+ability+to+stay+awake+in+a+sex-and+weight-specific+manner.&volume=12&issue=1&spage=379&epage=&date=2022&doi=10.1038%2Fs41398-022-02146-y&pmid=36088460&sid=OVID:medline
+
+<422>
+Unique Identifier
+ 36079858
+Title
+ Mediation Effect of Platelet Traits on Associations of Central Obesity with Aging Biomarkers in Rural Adults of Henan, China.
+Source
+ Nutrients. 14(17), 2022 Aug 31.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen X; Li R; Hou X; Wang Y; Pan M; Kang N; Yuchi Y; Liao W; Liu X; Mao Z; Huo W; Wang C; Hou J
+Author NameID
+ Huo, Wenqian; ORCID: https://orcid.org/0000-0002-7898-093X
+ Wang, Chongjian; ORCID: https://orcid.org/0000-0001-5091-6621
+Authors Full Name
+ Chen, Xinwei; Li, Ruiying; Hou, Xiaoyu; Wang, Yuqin; Pan, Mingming; Kang, Ning; Yuchi, Yinghao; Liao, Wei; Liu, Xiaotian; Mao, Zhenxing; Huo, Wenqian; Wang, Chongjian; Hou, Jian.
+Institution
+ Chen, Xinwei. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Li, Ruiying. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Hou, Xiaoyu. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Wang, Yuqin. Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China.
+ Pan, Mingming. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Kang, Ning. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Yuchi, Yinghao. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Liao, Wei. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Liu, Xiaotian. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Mao, Zhenxing. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Huo, Wenqian. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Wang, Chongjian. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+ Hou, Jian. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aging
+ Biomarkers
+ Body Mass Index
+ China
+ Cross-Sectional Studies
+ DNA, Mitochondrial
+ Humans
+ Middle Aged
+ *Obesity
+ *Obesity, Abdominal
+ Risk Factors
+ Waist Circumference
+ Waist-Hip Ratio
+ Young Adult
+Keyword Heading
+ mediating effect
+ mitochondrial DNA copy number
+ obesity
+ platelet traits
+ telomere length
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: To assess the associations of platelet traits and obesity indices with aging biomarkers (telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN)).
+
+ METHODS: A cross-sectional study was performed among 5091 rural Chinese adults. Obesity indices (waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR)) and platelet traits (plateletcrit (PCT), platelet large cell ratio (P-LCR), mean platelet volume (MPV) and platelet distribution width (PDW)) were collected by physical examination. The aging biomarkers were determined by quantitative real-time polymerase chain reaction. Generalized linear regression models and mediation analysis were applied to explore the relationships between platelet traits, obesity indices, and aging biomarkers.
+
+ RESULTS: The mean age of the participants was 56 years (range: 18-79). Each one-unit increment in WC, WHR and WHtR were related to a 0.316 (95% confidence interval (CI): -0.437, -0.196), 0.323 (95% CI: -0.513, -0.134) and 0.277 (95% CI: -0.400, -0.153) decrease in relative TL; or a 0.102 (95% CI: -0.197, -0.007), 0.109 (95% CI: -0.258, -0.041) and 0.101 (95% CI: -0.199, -0.004) decrease in relative mtDNA-CN. The proportions of obesity indices with aging biomarkers mediated by platelet indices ranged from 2.85% to 10.10%.
+
+ CONCLUSIONS: Increased central obesity indices in relation to shortened relative TL or decreased mtDNA-CN were mediated by platelet traits, indicating that obesity in association with the accelerated aging process may be partially attributable to abnormal platelet activity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (DNA, Mitochondrial).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14173597
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=2072-6643&title=Nutrients&atitle=Mediation+Effect+of+Platelet+Traits+on+Associations+of+Central+Obesity+with+Aging+Biomarkers+in+Rural+Adults+of+Henan%2C+China.&volume=14&issue=17&spage=&epage=&date=2022&doi=10.3390%2Fnu14173597&pmid=36079858&sid=OVID:medline
+
+<423>
+Unique Identifier
+ 36079796
+Title
+ Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites.
+Source
+ Nutrients. 14(17), 2022 Aug 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moin ASM; Sathyapalan T; Atkin SL; Butler AE
+Author NameID
+ Sathyapalan, Thozhukat; ORCID: https://orcid.org/0000-0003-3544-2231
+ Butler, Alexandra E; ORCID: https://orcid.org/0000-0002-5762-3917
+Authors Full Name
+ Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Atkin, Stephen L; Butler, Alexandra E.
+Institution
+ Moin, Abu Saleh Md. Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.
+ Sathyapalan, Thozhukat. Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Hull YO10 5DD, UK.
+ Atkin, Stephen L. Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.
+ Butler, Alexandra E. Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Female
+ Humans
+ Inflammation/co [Complications]
+ *Insulin Resistance
+ Obesity
+ *Polycystic Ovary Syndrome
+ Vitamin D
+ Vitamins
+Keyword Heading
+ inflammation
+ matrix metalloproteinases
+ polycystic ovary syndrome
+ vitamin D3
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Chronic low-grade inflammation is a characteristic of women with polycystic ovary syndrome (PCOS), although this may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, vitamin D deficiency, another common feature of PCOS, is reported to have an association with increased inflammation. Therefore, circulating inflammatory protein levels and circulating levels of vitamin D may be linked in PCOS, though it is unclear which vitamin D metabolites may be important.
+
+ METHODS: We measured plasma levels of 24 inflammatory proteins and 12 matrix metalloproteinases (proteins modulated by the inflammatory process) by slow off-rate modified aptamer (SOMA)-scan plasma protein measurement in weight and aged-matched non-obese non-insulin resistant PCOS (n = 24) and control (n = 24) women. Inflammatory proteins and matrix metalloproteinases were correlated to 25-hydroxy vitamin D3 (25(OH)D3), its epimer 25-hydroxy-3epi-vitamin D (3epi25(OH)D) and the active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) as measured by gold standard isotope-dilution liquid chromatography tandem mass spectrometry.
+
+ RESULTS: PCOS women had both an elevated free androgen index and circulating anti-mullerian hormone, though insulin resistance was comparable to controls. C-reactive protein, as a standard circulatory marker of inflammation, was comparable between cohorts. Levels of circulating inflammatory proteins and matrix metalloproteinases were not different between the PCOS and control women, with no correlation of 25(OH)D3, 1,25(OH)2D3 or 3epi25(OH)D with any of the inflammatory proteins.
+
+ CONCLUSION: In a non-obese PCOS population matched for age and insulin resistance, circulating inflammatory proteins and matrix metalloproteinases were not elevated and did not correlate with 25(OH)D3, its epimer 3epi25(OH)D or 1,25(OH)2D3 in either control or PCOS women, indicating that the inflammatory response is absent and the vitamin D-metabolite independent in non-obese women with PCOS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Vitamins). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14173540
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moin&issn=2072-6643&title=Nutrients&atitle=Inflammatory+Markers+in+Non-Obese+Women+with+Polycystic+Ovary+Syndrome+Are+Not+Elevated+and+Show+No+Correlation+with+Vitamin+D+Metabolites.&volume=14&issue=17&spage=&epage=&date=2022&doi=10.3390%2Fnu14173540&pmid=36079796&sid=OVID:medline
+
+<424>
+Unique Identifier
+ 36079745
+Title
+ Association between Obesity, Overweight, Elevated Waist Circumference, and Insulin Resistance Markers among Brazilian Adolescent Students.
+Source
+ Nutrients. 14(17), 2022 Aug 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Deusdara R; de Moura Souza A; Szklo M
+Author NameID
+ Deusdara, Rodolfo; ORCID: https://orcid.org/0000-0002-1343-3265
+Authors Full Name
+ Deusdara, Rodolfo; de Moura Souza, Amanda; Szklo, Moyses.
+Institution
+ Deusdara, Rodolfo. Faculdade de Medicina, Universidade de Brasilia, UnB, Campus Universitario Darcy Ribeiro, Asa Norte, Brasilia 70910-900, DF, Brazil.
+ Deusdara, Rodolfo. Instituto de Estudos em Saude Coletiva, Universidade Federal do Rio de Janeiro, Avenida Horacio Macedo, S/N-Proxima a Prefeitura Universitaria da UFRJ, Ilha do Fundao-Cidade Universitaria, Rio de Janeiro 21941-598, RJ, Brazil.
+ de Moura Souza, Amanda. Instituto de Estudos em Saude Coletiva, Universidade Federal do Rio de Janeiro, Avenida Horacio Macedo, S/N-Proxima a Prefeitura Universitaria da UFRJ, Ilha do Fundao-Cidade Universitaria, Rio de Janeiro 21941-598, RJ, Brazil.
+ Szklo, Moyses. Epidemiology Department, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street Room W6009, Baltimore, MD 21205, USA.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Brazil/ep [Epidemiology]
+ Humans
+ Insulin
+ *Insulin Resistance
+ Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ Students
+ Triglycerides
+ Waist Circumference
+Keyword Heading
+ adolescent
+ biomarkers
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ (1) Background: There is still controversy concerning the most effective and efficient strategy to identify insulin resistance in adolescents. We estimated the level of fasting insulin (fasting insulin equivalent, FIeq) that would replicate the strength of the associations of obesity, overweight, and waist circumference with two insulin resistance markers: triglyceride/high-density lipoprotein (TG/HDL) and triglyceride/glucose (TyG); (2) Methods: We studied approximately 38,000 adolescents aged 12 to 17 years, sampled from a multicenter Brazilian school-based survey, The Study of Cardiovascular Risk Factors in Adolescents (Portuguese acronym, ERICA), conducted in 2013-2014. Fasting insulin equivalents for adiposity variables were calculated by dividing the beta coefficient of each adiposity measure by the fasting insulin beta coefficient from linear regression analysis according to age (12-14, 15-17 years old) and sex, and adjusted by smoking, alcohol consumption, physical inactivity, sedentary behavior, socioeconomic status, and Tanner stage; (3) Results: The FIeqs for obesity were greater than those for overweight and elevated waist circumference for both TG/HDL and TyG in early adolescence. The FIeqs for elevated WC were greater than those for obesity and overweight in adolescents aged 15 to 17 years; (4) Conclusions: Our study suggests that WC measurements might be useful to identify adolescents with insulin resistance, particularly in late adolescence.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Triglycerides).
+Publication Type
+ Journal Article. Multicenter Study.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14173487
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Deusdara&issn=2072-6643&title=Nutrients&atitle=Association+between+Obesity%2C+Overweight%2C+Elevated+Waist+Circumference%2C+and+Insulin+Resistance+Markers+among+Brazilian+Adolescent+Students.&volume=14&issue=17&spage=&epage=&date=2022&doi=10.3390%2Fnu14173487&pmid=36079745&sid=OVID:medline
+
+<425>
+Unique Identifier
+ 36078265
+Title
+ School Feeding as a Protective Factor against Insulin Resistance: The Study of Cardiovascular Risks in Adolescents (ERICA).
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 19(17), 2022 08 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Okamura AB; Goncalves VSS; de Carvalho KMB
+Author NameID
+ Okamura, Aline Bassetto; ORCID: https://orcid.org/0000-0002-8324-8460
+ Goncalves, Vivian Siqueira Santos; ORCID: https://orcid.org/0000-0001-6893-8263
+Authors Full Name
+ Okamura, Aline Bassetto; Goncalves, Vivian Siqueira Santos; de Carvalho, Kenia Mara Baiocchi.
+Institution
+ Okamura, Aline Bassetto. Graduate Program in Public Health, Faculty of Health Sciences, University of Brasilia, Campus Universitario Darcy Ribeiro S/N, Asa Norte, Brasilia 70910-900, Brazil.
+ Goncalves, Vivian Siqueira Santos. Graduate Program in Public Health, Faculty of Health Sciences, University of Brasilia, Campus Universitario Darcy Ribeiro S/N, Asa Norte, Brasilia 70910-900, Brazil.
+ de Carvalho, Kenia Mara Baiocchi. Graduate Program in Public Health, Faculty of Health Sciences, University of Brasilia, Campus Universitario Darcy Ribeiro S/N, Asa Norte, Brasilia 70910-900, Brazil.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ Blood Glucose
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Child
+ Cross-Sectional Studies
+ Female
+ Heart Disease Risk Factors
+ Humans
+ Insulin
+ *Insulin Resistance
+ Male
+ Obesity/ep [Epidemiology]
+ Protective Factors
+ Risk Factors
+Keyword Heading
+ adolescent
+ adolescent health
+ insulin resistance
+ multilevel analysis
+ school feeding
+ school food environment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The objective of this study was to use ERICA data from adolescents from Brazilian public schools to investigate the role of school feeding in insulin resistance markers. Public school students (12-17 years old) with available biochemical examinations were selected. Adolescents answered a self-administered questionnaire, and contextual characteristics were obtained through interviews with principals. A multilevel mixed-effects generalized linear model was performed at the contextual and individual levels with each insulin resistance marker (fasting insulin, HOMA-IR, and blood glucose levels). A total of 27,990 adolescents were evaluated (50.2% female). The prevalence of (1) altered insulin was 12.2% (95% CI; 11.1, 13.5), (2) high HOMA-IR was 24.7% (95% CI; 22.8, 26.7), and (3) high blood glucose was 4.6% (95% CI; 3.8, 5.4). School feeding was positively associated with an insulin resistance marker, decreasing by 0.135 units of HOMA-IR (95% CI; -0.19, -0.08), 0.469 muU/L of insulin levels (95% CI; -0.66, -0.28), and 0.634 mg/dL of blood glucose (95% CI; -0.87, -0.39). In turn, buying food increased blood glucose by 0.455 mg/dL (95% CI; 0.16, 0.75). School feeding was positively associated with insulin resistance variables, demonstrating the potential of planned meals in the school environment to serve as a health promoter for the adolescent population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijerph191710551
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Okamura&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=School+Feeding+as+a+Protective+Factor+against+Insulin+Resistance%3A+The+Study+of+Cardiovascular+Risks+in+Adolescents+%28ERICA%29.&volume=19&issue=17&spage=&epage=&date=2022&doi=10.3390%2Fijerph191710551&pmid=36078265&sid=OVID:medline
+
+<426>
+Unique Identifier
+ 36071605
+Title
+ Association between triglyceride glucose index and carotid intima-media thickness in obese and nonobese adults.
+Source
+ Journal Of Diabetes. 14(9):596-605, 2022 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jia X; Zhu Y; Qi Y; Zheng R; Lin L; Hu C; Zhang Y; Wu X; Qi H; Wei R; Zhang J; Xu M; Xu Y; Wang T; Zhao Z; Chen Y; Bi Y; Wang W; Li M; Lu J
+Author NameID
+ Zhu, Yuanyue; ORCID: https://orcid.org/0000-0003-3114-3314
+ Hu, Chunyan; ORCID: https://orcid.org/0000-0002-8673-3859
+ Wu, Xueyan; ORCID: https://orcid.org/0000-0001-9127-7854
+ Zhang, Jie; ORCID: https://orcid.org/0000-0001-7635-3898
+ Xu, Min; ORCID: https://orcid.org/0000-0003-3930-8718
+ Wang, Tiange; ORCID: https://orcid.org/0000-0003-0723-489X
+ Zhao, Zhiyun; ORCID: https://orcid.org/0000-0001-5950-2732
+ Chen, Yuhong; ORCID: https://orcid.org/0000-0002-6506-2283
+ Li, Mian; ORCID: https://orcid.org/0000-0001-6514-2729
+ Lu, Jieli; ORCID: https://orcid.org/0000-0003-1317-0896
+Authors Full Name
+ Jia, Xiaojing; Zhu, Yuanyue; Qi, Yan; Zheng, Ruizhi; Lin, Lin; Hu, Chunyan; Zhang, Yi; Wu, Xueyan; Qi, Hongyan; Wei, Ran; Zhang, Jie; Xu, Min; Xu, Yu; Wang, Tiange; Zhao, Zhiyun; Chen, Yuhong; Bi, Yufang; Wang, Weiqing; Li, Mian; Lu, Jieli.
+Institution
+ Jia, Xiaojing. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Jia, Xiaojing. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhu, Yuanyue. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhu, Yuanyue. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Qi, Yan. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Qi, Yan. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zheng, Ruizhi. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zheng, Ruizhi. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Lin, Lin. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Lin, Lin. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Hu, Chunyan. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Hu, Chunyan. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhang, Yi. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhang, Yi. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Wu, Xueyan. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Wu, Xueyan. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Qi, Hongyan. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Qi, Hongyan. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Wei, Ran. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Wei, Ran. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhang, Jie. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhang, Jie. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Xu, Min. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Xu, Min. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Xu, Yu. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Xu, Yu. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Wang, Tiange. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Wang, Tiange. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhao, Zhiyun. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhao, Zhiyun. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Chen, Yuhong. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Chen, Yuhong. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Bi, Yufang. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Bi, Yufang. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Wang, Weiqing. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Wang, Weiqing. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Li, Mian. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Li, Mian. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Lu, Jieli. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Lu, Jieli. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+MeSH Subject Headings
+ Adult
+ Humans
+ Biomarkers
+ Blood Glucose
+ *Carotid Intima-Media Thickness
+ Electrolytes
+ *Glucose
+ Obesity/co [Complications]
+ Prospective Studies
+ Risk Factors
+ Triglycerides
+Keyword Heading
+ carotid intima-media thickness
+ nonlinear relationship
+ obesity
+ triglyceride glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The triglyceride glucose (TyG) index is closely associated with subclinical atherosclerosis. However, the association remains inconclusive among obese and nonobese individuals.
+
+ METHODS: This prospective study was conducted in 5751 adults with normal carotid intima-media thickness (CIMT) at baseline. We divided the population into four groups based on the TyG index, which was calculated by the following formula: Ln (fasting triglycerides [mg/dL] x fasting glucose [mg/dL]/2). Information on CIMT was acquired by ultrasonography. Incident elevated CIMT was defined as IMT values greater than 0.9 mm at follow-up. Odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between TyG index and elevated CIMT were estimated using multivariable logistic regression models.
+
+ RESULTS: After a median follow-up of 4.3 years, 722 (12.6%) individuals had progressed to elevated CIMT. Compared with the second quartile of the TyG index, the first and fourth quartile both conferred higher risks of elevated CIMT after adjusting for potential confounders. In the total population, the ORs for the first and fourth quartile were 1.29 (95% CI, 1.00-1.66) and 1.42 (95% CI, 1.11-1.83), respectively. Restricted cubic splines demonstrated an approximately U-shaped association between TyG index and elevated CIMT among the total and nonobese adults (P for nonlinearity <.05), but not in those with general or abdominal obesity.
+
+ CONCLUSIONS: A U-shaped association was observed between TyG index and elevated CIMT only among nonobese Chinese adults. Copyright © 2022 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.
+Other Abstract
+ Publisher
+ : (TyG) , : 5751 (CIMT) TyG , :Ln( [mg/dL]x [mg/dL]/2) CIMT CIMT IMT 0.9 mm Logistic TyG CIMT (OR) 95% (CI) : 4.3 , 722 (12.6%) CIMT TyG , , CIMT , OR 1.29(95%CI,1.00~1.66) 1.42(95%CI,1.11~1.83) TyG CIMT U (P<0.05), : ,TyG CIMT U .
+ Language: Chinese
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Electrolytes). IY9XDZ35W2 (Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2f1753-0407.13312
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jia&issn=1753-0407&title=Journal+Of+Diabetes&atitle=Association+between+triglyceride+glucose+index+and+carotid+intima-media+thickness+in+obese+and+nonobese+adults.&volume=14&issue=9&spage=596&epage=605&date=2022&doi=10.1111%2F1753-0407.13312&pmid=36071605&sid=OVID:medline
+
+<427>
+Unique Identifier
+ 36058762
+Title
+ Effect of nuts on components of metabolic syndrome in healthy adults with overweight/obesity: A systematic review and meta-analysis.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 32(11):2459-2469, 2022 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Eslami O; Khorramrouz F; Sohouli M; Bagheri N; Shidfar F; Fernandez ML
+Authors Full Name
+ Eslami, Omid; Khorramrouz, Fatemeh; Sohouli, Mohammadhassan; Bagheri, Niloofar; Shidfar, Farzad; Fernandez, Maria Luz.
+Institution
+ Eslami, Omid. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Khorramrouz, Fatemeh. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Sohouli, Mohammadhassan. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Bagheri, Niloofar. Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
+ Shidfar, Farzad. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address: shidfar.f@iums.ac.ir.
+ Fernandez, Maria Luz. Department of Nutritional Sciences, University of Connecticut, Storrs, CT, 06269, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Blood Glucose
+ Cholesterol, HDL
+ Cholesterol, LDL
+ Humans
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/pc [Prevention & Control]
+ *Metabolic Syndrome
+ *Nuts
+ Obesity/di [Diagnosis]
+ Overweight/di [Diagnosis]
+ Triglycerides
+Keyword Heading
+ Dyslipidemias
+ Metabolic syndrome
+ Metabolically healthy obesity
+ Nuts
+ Obesity
+ Overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Randomized controlled trials evaluating the effects of nut consumption on the metabolic profile of healthy adults with overweight/obesity have yielded conflicting results. This systematic review and meta-analysis aimed to summarize the effects of incorporating nuts into the diet on serum lipid profile, glycemic markers, and blood pressure in healthy adults with overweight/obesity.
+
+ DATA SYNTHESIS: PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched up to April 2021. The random-effects model was used to determine the pooled effect sizes expressed as weighted mean difference (WMD) with % 95 confidence intervals (CIs). Ten eligible RCTs (with 12 arms) were included in the meta-analysis. The meta-analysis revealed that nut intake significantly decreased serum triglycerides (TG) (WMD: -13.19 mg/dL, 95% CI: - 25.90, - 0.48). Furthermore, subgroup analysis showed a significant reduction in serum LDL-cholesterol (LDL-C) following adherence to normocaloric, nut-enriched diets (WMD: - 4.56 mg/dL, 95% CI: - 8.24, - 0.88). However, nuts did not affect serum total cholesterol, high-density lipoprotein cholesterol, glycemic markers, and blood pressure.
+
+ CONCLUSIONS: Overall, incorporating nuts into the diet of healthy adults with overweight/obesity have favorable effects on serum TG and LDL-C. Thus, nuts might exert protective effects against dyslipidemia in this population.
+
+ REGISTRY NUMBER: PROPSPERO CRD42021250662. Copyright © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Triglycerides).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.numecd.2022.07.015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Eslami&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Effect+of+nuts+on+components+of+metabolic+syndrome+in+healthy+adults+with+overweight%2Fobesity%3A+A+systematic+review+and+meta-analysis.&volume=32&issue=11&spage=2459&epage=2469&date=2022&doi=10.1016%2Fj.numecd.2022.07.015&pmid=36058762&sid=OVID:medline
+
+<428>
+Unique Identifier
+ 36028067
+Title
+ Serum uric acid is a predictive biomarker of incident metabolic syndrome at the Brazilian longitudinal study of adult Health (ELSA - Brasil).
+Source
+ Diabetes Research & Clinical Practice. 191:110046, 2022 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Haueisen Sander Diniz MF; M R Beleigoli A; Isabel Rodrigues Galvao A; Weiss Telles R; Ines Schmidt M; B Duncan B; M Bensenor I; Luiz P Ribeiro A; Vidigal PG; Maria Barreto S
+Authors Full Name
+ Haueisen Sander Diniz, Maria de Fatima; M R Beleigoli, Alline; Isabel Rodrigues Galvao, Aline; Weiss Telles, Rosa; Ines Schmidt, Maria; B Duncan, Bruce; M Bensenor, Isabela; Luiz P Ribeiro, Antonio; Vidigal, Pedro G; Maria Barreto, Sandhi.
+Institution
+ Haueisen Sander Diniz, Maria de Fatima. Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: mfhsdiniz@ufmg.br.
+ M R Beleigoli, Alline. Flinders University, Adelaide, Australia.
+ Isabel Rodrigues Galvao, Aline. Endocrinology and Metabolism Division, Hospital das Clinicas da Universidade Federal de Minas Gerais, Brazil.
+ Weiss Telles, Rosa. Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Ines Schmidt, Maria. Postgraduate Studies Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
+ B Duncan, Bruce. Postgraduate Studies Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
+ M Bensenor, Isabela. Faculty of Medicine, Universidade de Sao Paulo, Sao Paulo, Brazil.
+ Luiz P Ribeiro, Antonio. Telehealth Center and Cardiology Service, Hospital das Clinicas, and Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Vidigal, Pedro G. Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Maria Barreto, Sandhi. Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Brazil/ep [Epidemiology]
+ Humans
+ Hyperuricemia/di [Diagnosis]
+ Hyperuricemia/ep [Epidemiology]
+ *Hyperuricemia
+ Longitudinal Studies
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome
+ Obesity
+ Overweight/ep [Epidemiology]
+ Risk Factors
+ Uric Acid
+Keyword Heading
+ Biomarker
+ Cohort
+ Hyperuricemia
+ Incidence study
+ Metabolic syndrome
+ Uric acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To investigate whether serum uric acid (SUA) levels and hyperuricemia can be predictive biomarkers of incident metabolic syndrome(MS) among different body mass index(BMI) categories, and to investigate SUA cutoffs that best discriminate individuals with incident MS.
+
+ METHODS: We analyzed 7,789 participants without MS at baseline of ELSA-Brasil study. Logistic regression models were performed to evaluate associations between incident MS and SUA levels/hyperuricemia, expressed by odds ratios(ORs) and confidence intervals(95 % CI).
+
+ RESULTS: We found 1,646 incident MS cases after a median follow-up of 3.8[3.5-4.1] years. Incident MS was present among 8.3 % (n = 290) of participants with normal weight, 28.3 % (n = 850) with overweight, 39.8 % (n = 506) with obesity. Among incident MS participants of total sample, 33.0 % had hyperuricemia [SUA > 6.0 mg/dL (356.9 mumol/L)]. After all adjustments, SUA was independently prognostic of incident MS: for each 1 mg/dL increase in SUA the odds of incident MS were 45 % higher (OR1.45[CI95 %1.34-1.55 p <.01]). Associations were found for those presenting normal weight, overweight and obesity (OR1.43[CI95 %1.31-1.57 p <.01; OR1.22[CI95 %1.13-1.32 p <.01]; and OR1.16[CI95 %1.04-1.29 p <.05]) respectively. Hyperuricemia was independently associated with incident MS (OR1.88[CI95 %1.49-0.2.36 p <.01]). The SUA cut point level maximizing sensitivity and specificity in the discrimination of incident MS was 5.0 mg/dL.
+
+ CONCLUSIONS: SUA level is an independent predictive biomarker of incident MS at all BMI categories. Copyright © 2022 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.diabres.2022.110046
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Haueisen+Sander+Diniz&issn=0168-8227&title=Diabetes+Research+%26+Clinical+Practice&atitle=Serum+uric+acid+is+a+predictive+biomarker+of+incident+metabolic+syndrome+at+the+Brazilian+longitudinal+study+of+adult+Health+%28ELSA+-+Brasil%29.&volume=191&issue=&spage=110046&epage=&date=2022&doi=10.1016%2Fj.diabres.2022.110046&pmid=36028067&sid=OVID:medline
+
+<429>
+Unique Identifier
+ 36006465
+Title
+ Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose Cells.
+Source
+ Diabetes. 71(11):2372-2383, 2022 11 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gustafson B; Nerstedt A; Spinelli R; Beguinot F; Smith U
+Author NameID
+ Beguinot, Francesco; ORCID: https://orcid.org/0000-0002-4946-7803
+ Smith, Ulf; ORCID: https://orcid.org/0000-0002-1439-4608
+Authors Full Name
+ Gustafson, Birgit; Nerstedt, Annika; Spinelli, Rosa; Beguinot, Francesco; Smith, Ulf.
+Institution
+ Gustafson, Birgit. The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
+ Nerstedt, Annika. The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
+ Spinelli, Rosa. Department of Translational Medical Sciences, Federico II University of Naples, and URT Genomics of Diabetes, Institute of Experimental Endocrinology and Oncology, National Research Council, Naples, Italy.
+ Beguinot, Francesco. Department of Translational Medical Sciences, Federico II University of Naples, and URT Genomics of Diabetes, Institute of Experimental Endocrinology and Oncology, National Research Council, Naples, Italy.
+ Smith, Ulf. The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
+MeSH Subject Headings
+ Humans
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Cyclin D1/me [Metabolism]
+ Culture Media, Conditioned/me [Metabolism]
+ Peroxisome Proliferator-Activated Receptors/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Obesity/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ *Insulin Resistance
+ Glucose/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Insulins/me [Metabolism]
+ *Insulins
+Abstract
+ Obesity with dysfunctional adipose cells is the major cause of the current epidemic of type 2 diabetes (T2D). We examined senescence in human adipose tissue cells from age- and BMI-matched individuals who were lean, obese, and obese with T2D. In obese individuals and, more pronounced, those with T2D, we found mature and fully differentiated adipose cells to exhibit increased senescence similar to what we previously have shown in the progenitor cells. The degree of adipose cell senescence was positively correlated with whole-body insulin resistance and adipose cell size. Adipose cell protein analysis revealed dysfunctional cells in T2D with increased senescence markers reduced PPAR-gamma, GLUT4, and pS473AKT. Consistent with a recent study, we found the cell cycle regulator cyclin D1 to be increased in obese cells and further elevated in T2D cells, closely correlating with senescence markers, ambient donor glucose, and, more inconsistently, plasma insulin levels. Furthermore, fully differentiated adipose cells were susceptible to experimentally induced senescence and to conditioned medium increasing cyclin D1 and responsive to senolytic agents. Thus, fully mature human adipose cells from obese individuals, particularly those with T2D become senescent, and SASP secretion by senescent progenitor cells can play an important role in addition to donor hyperinsulinemia. Copyright © 2022 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 136601-57-5 (Cyclin D1). 0 (Culture Media, Conditioned). 0 (Peroxisome Proliferator-Activated Receptors). IY9XDZ35W2 (Glucose). 0 (Biomarkers). 0 (Insulins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.2337%2fdb22-0003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gustafson&issn=0012-1797&title=Diabetes&atitle=Type+2+Diabetes%2C+Independent+of+Obesity+and+Age%2C+Is+Characterized+by+Senescent+and+Dysfunctional+Mature+Human+Adipose+Cells.&volume=71&issue=11&spage=2372&epage=2383&date=2022&doi=10.2337%2Fdb22-0003&pmid=36006465&sid=OVID:medline
+
+<430>
+Unique Identifier
+ 35978103
+Title
+ Relationships between intrauterine fetal growth trajectories and markers of adiposity and inflammation in young adults.
+Source
+ International Journal of Obesity. 46(10):1925-1935, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yadav A; Beilin LJ; Huang RC; Vlaskovsky P; Newnham JP; White SW; Mori TA
+Author NameID
+ Yadav, Ashish; ORCID: http://orcid.org/0000-0001-6408-1602
+ Beilin, Lawrence J; ORCID: http://orcid.org/0000-0003-4853-7360
+ Mori, Trevor A; ORCID: http://orcid.org/0000-0002-5264-9229
+Authors Full Name
+ Yadav, Ashish; Beilin, Lawrence J; Huang, Rae-Chi; Vlaskovsky, Phil; Newnham, John P; White, Scott W; Mori, Trevor A.
+Institution
+ Yadav, Ashish. Medical School, University of Western Australia, Perth, WA, Australia.
+ Beilin, Lawrence J. Medical School, University of Western Australia, Perth, WA, Australia.
+ Huang, Rae-Chi. Nutrition Health Innovation Research Institute, Edith Cowan University, Perth, WA, Australia.
+ Vlaskovsky, Phil. Medical School, University of Western Australia, Perth, WA, Australia.
+ Newnham, John P. Division of Obstetrics and Gynaecology, University of Western Australia, Perth, WA, Australia.
+ White, Scott W. Division of Obstetrics and Gynaecology, University of Western Australia, Perth, WA, Australia.
+ Mori, Trevor A. Medical School, University of Western Australia, Perth, WA, Australia. trevor.mori@uwa.edu.au.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Australia/ep [Epidemiology]
+ Biomarkers
+ *C-Reactive Protein
+ Female
+ Fetal Development
+ Gestational Age
+ Humans
+ Inflammation
+ Obesity
+ Pregnancy
+ Ultrasonography, Prenatal
+ Young Adult
+Abstract
+ BACKGROUND: There is now good evidence that events during gestation significantly influence the developmental well-being of an individual in later life. This study aimed to investigate the relationships between intrauterine growth trajectories determined by serial ultrasound and subsequent markers of adiposity and inflammation in the 27-year-old adult offspring from the Raine Study, an Australian longitudinal pregnancy cohort.
+
+ METHODS: Ultrasound fetal biometric measurements including abdominal circumference (AC), femur length (FL), and head circumference (HC) from 1333 mother-fetal pairs (Gen1-Gen2) in the Raine Study were used to develop fetal growth trajectories using group-based trajectory modeling. Linear mixed modeling investigated the relationship between adult body mass index (BMI), waist circumference (WC), and high-sensitivity C-reactive protein (hs-CRP) of Gen2 at 20 (n = 485), 22 (n = 421) and 27 (n = 437) years and the fetal growth trajectory groups, adjusting for age, sex, adult lifestyle factors, and maternal factors during pregnancy.
+
+ RESULTS: Seven AC, five FL and five HC growth trajectory groups were identified. Compared to the average-stable (reference) group, a lower adult BMI was observed in two falling AC trajectories: (beta = -1.45 kg/m2, 95% CI: -2.43 to -0.46, P = 0.004) and (beta = -1.01 kg/m2, 95% CI: -1.96 to -0.05, P = 0.038). Conversely, higher adult BMI (2.58 kg/m2, 95% CI: 0.98 to 4.18, P = 0.002) and hs-CRP (37%, 95% CI: 9-73%, P = 0.008) were observed in a rising FL trajectory compared to the reference group. A high-stable HC trajectory associated with 20% lower adult hs-CRP (95% CI: 5-33%, P = 0.011).
+
+ CONCLUSION: This study highlights the importance of understanding causes of the unique patterns of intrauterine growth. Different fetal growth trajectories from early pregnancy associate with subsequent adult adiposity and inflammation, which predispose to the risk of diabetes and cardiometabolic disease. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41366-022-01203-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yadav&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Relationships+between+intrauterine+fetal+growth+trajectories+and+markers+of+adiposity+and+inflammation+in+young+adults.&volume=46&issue=10&spage=1925&epage=1935&date=2022&doi=10.1038%2Fs41366-022-01203-2&pmid=35978103&sid=OVID:medline
+
+<431>
+Unique Identifier
+ 35971882
+Title
+ Copper fabric improves the metabolic profile of obese mice: Potential role of the gut microbiota.
+Source
+ Basic & Clinical Pharmacology & Toxicology. 131(5):355-363, 2022 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Song E; Vu V; Varin TV; Botta A; Marette A; Sweeney G
+Author NameID
+ Song, Erfei; ORCID: https://orcid.org/0000-0002-2492-5820
+Authors Full Name
+ Song, Erfei; Vu, Vivian; Varin, Thibault V; Botta, Amy; Marette, Andre; Sweeney, Gary.
+Institution
+ Song, Erfei. Department of Biology, York University, Toronto, Ontario, Canada.
+ Song, Erfei. The First Affiliated Hospital, Jinan University, Guangzhou, China.
+ Vu, Vivian. Department of Biology, York University, Toronto, Ontario, Canada.
+ Vu, Vivian. Department of Family and Community Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.
+ Varin, Thibault V. Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec, Quebec, Canada.
+ Botta, Amy. Department of Biology, York University, Toronto, Ontario, Canada.
+ Marette, Andre. Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec, Quebec, Canada.
+ Marette, Andre. Department of Medicine, Faculty of Medicine, Cardiology Axis of the Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada.
+ Sweeney, Gary. Department of Biology, York University, Toronto, Ontario, Canada.
+MeSH Subject Headings
+ Alloys/me [Metabolism]
+ Alloys/pd [Pharmacology]
+ Animals
+ *Anti-Infective Agents
+ Biomarkers/me [Metabolism]
+ Cholesterol
+ Copper/me [Metabolism]
+ Copper/pd [Pharmacology]
+ Diet, High-Fat
+ *Gastrointestinal Microbiome
+ Glucose/me [Metabolism]
+ *Insulin Resistance
+ Lipocalin-2/me [Metabolism]
+ Metabolome
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ Obesity/me [Metabolism]
+Keyword Heading
+ copper-infused fabric
+ gut microbiota
+ inflammation
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Copper and copper alloys have antimicrobial activity through the rapid contact killing of viruses, bacteria and yeasts on their surface. Dysregulation of host microbiota can contribute to the pathogenesis of inflammatory diseases such as obesity, diabetes and cardiovascular disease. Anecdotal evidence noted improved overall well-being in individuals sleeping on copper-containing fabric bedding. We hypothesized that the beneficial effect of copper-infused fabric bedding on cardiometabolic health is linked to changes in gut microbiota composition. This study utilized a mouse model of diet-induced obesity to assess the beneficial effects of copper-infused fabric bedding on metabolic health. Body composition, inflammatory markers, metabolic and cardiovascular status and changes in the faecal microbiota composition were evaluated for up to 2 months in mice fed with a normal chow diet or high fat high cholesterol diet in the presence of bedding made with and without copper-infused fabric. Results showed that mice subjected to diet-induced obesity and housed in cages with copper-infused fabric liner displayed less body weight gain than mice in cages with control fabric. Mice housed with copper-infused fabric also displayed improved glucose tolerance and reduced inflammation biomarker lipocalin-2. We also observed a beneficial shift in gut bacterial composition of obese mice housed with copper fabric bedding. Taken in conjunction, our study provides direct animal-based evidence supporting the beneficial effects of copper fabric on metabolic health. Copyright © 2022 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Alloys). 0 (Anti-Infective Agents). 0 (Biomarkers). 0 (Lipocalin-2). 789U1901C5 (Copper). 97C5T2UQ7J (Cholesterol). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2fbcpt.13778
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Song&issn=1742-7835&title=Basic+%26+Clinical+Pharmacology+%26+Toxicology&atitle=Copper+fabric+improves+the+metabolic+profile+of+obese+mice%3A+Potential+role+of+the+gut+microbiota.&volume=131&issue=5&spage=355&epage=363&date=2022&doi=10.1111%2Fbcpt.13778&pmid=35971882&sid=OVID:medline
+
+<432>
+Unique Identifier
+ 35970685
+Title
+ Elevated heart rate as sympathetic biomarker in human obesity.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 32(10):2367-2374, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Seravalle G; Facchetti R; Cappellini C; Annaloro A; Gelfi E; Grassi G
+Authors Full Name
+ Seravalle, Gino; Facchetti, Rita; Cappellini, Cecilia; Annaloro, Alessandra; Gelfi, Elia; Grassi, Guido.
+Institution
+ Seravalle, Gino. IRCCS Istituto Auxologico Italiano, Cardiology Department, St Luca Hospital, Piazza Brescia Milan, Italy.
+ Facchetti, Rita. Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
+ Cappellini, Cecilia. Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
+ Annaloro, Alessandra. Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
+ Gelfi, Elia. Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
+ Grassi, Guido. Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. Electronic address: guido.grassi@unimib.it.
+MeSH Subject Headings
+ Adrenergic Agents
+ Biomarkers
+ Blood Pressure
+ Heart Rate
+ Humans
+ Norepinephrine
+ *Obesity
+ *Sympathetic Nervous System
+Keyword Heading
+ Body mass index
+ HOMA index
+ Heart rate
+ Obesity
+ Plasma norepinephrine
+ Sympathetic activity
+ Sympathetic nerve traffic
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: The present study was aimed at determining whether and to what extent a specific heart rate (HR) cutoff value allows to identify in obeses a more pronounced level of adrenergic overdrive.
+
+ METHODS AND RESULTS: In 86 obese subjects aged 44.7 +/- 0.9 (mean +/- SEM) years and in 45 heathy lean controls of similar age we evaluated muscle sympathetic nerve traffic (MSNA, microneurography) and venous plasma norepinephrine (NE, HPLC assay), subdividing the subjects in 3 different groups according to their resting clinic and 24-h HR values (<70, 70-79 and 80-89 beats/minute). MSNA and plasma NE values detected in the three obese groups were almost superimposable each other, no significant difference between groups being observed. A similar behavior was observed when HR values were assessed during the 24-h Holter monitoring. In the group as a whole no significant relationship was detected between MSNA, plasma NE and clinic HR, this being the case also when 24-h HR replaced clinic HR in the correlation analysis. In contrast lean controls displayed a progressive significant increase in MSNA values form the group with clinic (and 24 Holter) values below 70 beats/minute to the ones with HR values between 70 and 79 and above 80 beats/minute.
+
+ CONCLUSIONS: In the obese state measurement of resting HR may allow to provide some general information on the functional status of the adrenergic cardiovascular drive. When the information required, however, are more subtle the sensitivity of the approach appears to be reduced and HR cannot be regarded as a faithful sympathetic biomarker. Copyright © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adrenergic Agents). 0 (Biomarkers). X4W3ENH1CV (Norepinephrine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.numecd.2022.07.011
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Seravalle&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Elevated+heart+rate+as+sympathetic+biomarker+in+human+obesity.&volume=32&issue=10&spage=2367&epage=2374&date=2022&doi=10.1016%2Fj.numecd.2022.07.011&pmid=35970685&sid=OVID:medline
+
+<433>
+Unique Identifier
+ 35945262
+Title
+ Heart failure in obesity: insights from proteomics in patients treated with or without weight-loss surgery.
+Source
+ International Journal of Obesity. 46(12):2088-2094, 2022 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karason K; Girerd N; Andersson-Asssarsson J; Duarte K; Taube M; Svensson PA; Huby AC; Peltonen M; Carlsson LM; Zannad F
+Author NameID
+ Karason, Kristjan; ORCID: https://orcid.org/0000-0002-2802-1191
+ Andersson-Asssarsson, Johanna; ORCID: https://orcid.org/0000-0001-9082-8589
+ Svensson, Per-Arne; ORCID: https://orcid.org/0000-0002-6731-806X
+ Peltonen, Markku; ORCID: https://orcid.org/0000-0002-3767-4223
+Authors Full Name
+ Karason, Kristjan; Girerd, Nicolas; Andersson-Asssarsson, Johanna; Duarte, Kevin; Taube, Magdalena; Svensson, Per-Arne; Huby, Anne-Cecile; Peltonen, Markku; Carlsson, Lena M; Zannad, Faiez.
+Institution
+ Karason, Kristjan. Department of Cardiology and Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden. kristjan.karason@medfak.gu.se.
+ Karason, Kristjan. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. kristjan.karason@medfak.gu.se.
+ Girerd, Nicolas. Centre d'Investigation Clinique 1433 module Plurithematique, CHRU Nancy-Hopitaux de Brabois, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, Vandoeuvre les Nancy, France.
+ Andersson-Asssarsson, Johanna. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Duarte, Kevin. Centre d'Investigation Clinique 1433 module Plurithematique, CHRU Nancy-Hopitaux de Brabois, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, Vandoeuvre les Nancy, France.
+ Taube, Magdalena. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Svensson, Per-Arne. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Svensson, Per-Arne. Institute of Health and Care Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
+ Huby, Anne-Cecile. Centre d'Investigation Clinique 1433 module Plurithematique, CHRU Nancy-Hopitaux de Brabois, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, Vandoeuvre les Nancy, France.
+ Peltonen, Markku. National Institute for Health and Welfare, Helsinki, Finland.
+ Carlsson, Lena M. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Zannad, Faiez. Centre d'Investigation Clinique 1433 module Plurithematique, CHRU Nancy-Hopitaux de Brabois, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, Vandoeuvre les Nancy, France.
+MeSH Subject Headings
+ Humans
+ *Proteomics
+ Case-Control Studies
+ *Heart Failure
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+ Biomarkers
+ Inflammation/co [Complications]
+ Hormones
+Abstract
+ BACKGROUND: Obesity is associated with incident heart failure (HF), but the underlying mechanisms are unclear.
+
+ METHODS: We performed a nested case-control study within the Swedish-Obese-Subjects study, by identifying 411 cases who developed HF and matched them with respect to age, sex, weight-loss-surgery and length of follow-up with 410 controls who did not develop HF. In analyses corrected for multiple testing, we studied 182 plasma proteins known to be related to cardiovascular disease to investigate whether they could add to the understanding of the processes underlying obesity-related HF.
+
+ RESULTS: A total of 821 subjects were followed for 16 +/- 6 years. Multivariable analysis adjusted for matching variables revealed that 32 proteins were significantly associated with HF. Twelve proteins were related to HF >= 80% of the time using a bootstrap resampling approach (false-discovery-rate [FDR] < 0.05): 11 were associated with increased HF-risk: TNFRSF10A*, ST6GAL1, PRCP, MMP12, TIMP1, CCL3, QPCT, ANG, C1QTNF1, SERPINA5 and GAL-9; and one was related to reduced HF-risk: LPL. An further 20 proteins were associated with onset of HF 50-80% of the time using bootstrap resampling (FDR < 0.05). A pathway analysis including all significant 32 proteins suggested that these biomarkers were related to inflammation, matrix remodeling, cardiometabolic hormones and hemostasis. Three proteins, C1QTNF1, FGF-21 and CST3, reflecting dyslipidemia and kidney disease, displayed a higher association with HF in patients who did not undergo weight-loss-surgery and maintained with obesity.
+
+ CONCLUSION: Pathways associated with HF in obesity include inflammation, matrix remodeling, cardiometabolic hormones and hemostasis; three protein biomarkers predicting HF appeared to be obesity-specific. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hormones).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41366-022-01194-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karason&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Heart+failure+in+obesity%3A+insights+from+proteomics+in+patients+treated+with+or+without+weight-loss+surgery.&volume=46&issue=12&spage=2088&epage=2094&date=2022&doi=10.1038%2Fs41366-022-01194-0&pmid=35945262&sid=OVID:medline
+
+<434>
+Unique Identifier
+ 35943037
+Title
+ Optimizing the diagnostic utility of N-terminal pro-B-type natriuretic peptide for acute heart failure in obesity and beyond.
+Source
+ European Journal of Heart Failure. 24(9):1555-1558, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Richards AM
+Authors Full Name
+ Richards, A Mark.
+Institution
+ Richards, A Mark. Christchurch Heart Institute, University of Otago New Zealand, Dunedin, New Zealand.
+ Richards, A Mark. Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Biomarkers
+ Heart Failure/di [Diagnosis]
+ *Heart Failure
+ Humans
+ *Natriuretic Peptide, Brain
+ Obesity/co [Complications]
+ Peptide Fragments
+ ROC Curve
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1002%2fejhf.2653
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Richards&issn=1388-9842&title=European+Journal+of+Heart+Failure&atitle=Optimizing+the+diagnostic+utility+of+N-terminal+pro-B-type+natriuretic+peptide+for+acute+heart+failure+in+obesity+and+beyond.&volume=24&issue=9&spage=1555&epage=1558&date=2022&doi=10.1002%2Fejhf.2653&pmid=35943037&sid=OVID:medline
+
+<435>
+Unique Identifier
+ 35942720
+Title
+ Branched-chain amino acids as a novel biomarker of metabolic disturbances in women with polycystic ovary syndrome - literature review. [Review]
+Source
+ Ginekologia Polska. 93(8):665-669, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Szmygin H; Lenart-Lipinska M; Szydelko J; Wozniak S; Matyjaszek-Matuszek B
+Authors Full Name
+ Szmygin, Hanna; Lenart-Lipinska, Monika; Szydelko, Joanna; Wozniak, Slawomir; Matyjaszek-Matuszek, Beata.
+Institution
+ Szmygin, Hanna. Department of Endocrinology, Diabetology and Metabolic Disorders, Medical University of Lublin, Poland. koszelh@gmail.com.
+ Lenart-Lipinska, Monika. Department of Endocrinology, Diabetology and Metabolic Disorders, Medical University of Lublin, Poland.
+ Szydelko, Joanna. Department of Endocrinology, Diabetology and Metabolic Disorders, Medical University of Lublin, Poland.
+ Wozniak, Slawomir. 3rd Chair and Department of Gynecology, Medical University of Lublin, Poland.
+ Matyjaszek-Matuszek, Beata. Department of Endocrinology, Diabetology and Metabolic Disorders, Medical University of Lublin, Poland.
+MeSH Subject Headings
+ Animals
+ Humans
+ Female
+ Amino Acids, Branched-Chain/me [Metabolism]
+ Polycystic Ovary Syndrome/co [Complications]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ Polycystic Ovary Syndrome/me [Metabolism]
+ *Polycystic Ovary Syndrome
+ *Insulin Resistance
+ *Diabetes Mellitus, Type 2
+ Isoleucine
+ Leucine
+ Prediabetic State/co [Complications]
+ *Prediabetic State
+ Obesity/co [Complications]
+ Biomarkers
+ Valine
+Keyword Heading
+ PCOS
+ branched-chain amino acids
+ insulin resistance
+ metabolic syndrome
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Polycystic ovary syndrome (PCOS) is a common, heterogeneous endocrine disorder which effects 5-10% of reproductive-age women. Recently, an association between PCOS and an increased risk of developing metabolic disturbances, such as insulin resistance, prediabetes, type 2 diabetes mellitus as well as obesity has been emphasised. Branched-chain amino acids (BCAAs), including valine (Val), leucine (Leu) and isoleucine (Ile), are a group of essential amino acids that cannot be synthesized in human body and need to be obtained from food. Several recent studies provide evidence that plasma BCAAs also serve as crucial nutrient signals and metabolic regulators. Interestingly, latest metabolomics analysis shows abnormalities in amino acid catabolism and biosynthesis in patients with PCOS, particularly in BCAAs. A growing body of evidence proves that elevated levels of BCAAs may have adverse effects on metabolic health leading to the development of insulin resistance, prediabetes, type 2 diabetes mellitus and obesity both in human and animal models. The aim of this review is to assess the current state of knowledge about the potential role of BCAAs as a novel biomarker of metabolic disturbances in women with polycystic ovary syndrome based on recent scientific literature published up to July 2021 and searches of the PubMed, Google Scholar, and Web of Science databases.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 04Y7590D77 (Isoleucine). GMW67QNF9C (Leucine). 0 (Biomarkers). HG18B9YRS7 (Valine).
+Publication Type
+ Review. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.5603%2fGP.a2022.0079
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Szmygin&issn=0017-0011&title=Ginekologia+Polska&atitle=Branched-chain+amino+acids+as+a+novel+biomarker+of+metabolic+disturbances+in+women+with+polycystic+ovary+syndrome+-+literature+review.&volume=93&issue=8&spage=665&epage=669&date=2022&doi=10.5603%2FGP.a2022.0079&pmid=35942720&sid=OVID:medline
+
+<436>
+Unique Identifier
+ 35937842
+Title
+ Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome.
+Source
+ Frontiers in Endocrinology. 13:937089, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mir FA; Mall R; Iskandarani A; Ullah E; Samra TA; Cyprian F; Parray A; Alkasem M; Abdalhakam I; Farooq F; Abou-Samra AB
+Authors Full Name
+ Mir, Fayaz Ahmad; Mall, Raghvendra; Iskandarani, Ahmad; Ullah, Ehsan; Samra, Tareq A; Cyprian, Farhan; Parray, Aijaz; Alkasem, Meis; Abdalhakam, Ibrahem; Farooq, Faisal; Abou-Samra, Abdul-Badi.
+Institution
+ Mir, Fayaz Ahmad. Qatar Metabolic Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
+ Mall, Raghvendra. Qatar Computing Research Institute (QCRI), Hamad Bin Khalifa University, Doha, Qatar.
+ Mall, Raghvendra. Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, United States.
+ Iskandarani, Ahmad. Qatar Metabolic Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
+ Ullah, Ehsan. Qatar Computing Research Institute (QCRI), Hamad Bin Khalifa University, Doha, Qatar.
+ Samra, Tareq A. Qatar Metabolic Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
+ Cyprian, Farhan. College of Medicine, Qatar University (QU) Health, Qatar University, Doha, Qatar.
+ Parray, Aijaz. Qatar Neuroscience Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
+ Alkasem, Meis. Qatar Metabolic Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
+ Abdalhakam, Ibrahem. Qatar Metabolic Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
+ Farooq, Faisal. Qatar Computing Research Institute (QCRI), Hamad Bin Khalifa University, Doha, Qatar.
+ Abou-Samra, Abdul-Badi. Qatar Metabolic Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Creatinine
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Metabolic Networks and Pathways
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/ge [Genetics]
+ *Metabolic Syndrome
+ MicroRNAs/ge [Genetics]
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+Keyword Heading
+ HbA1c
+ metabolic disorder
+ miRNA
+ mirDIP
+ network analysis
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Obesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in obese Qatari individuals.
+
+ Methods: We analyzed a dataset of 39 age-matched patients that includes 18 subjects with obesity only (OBO) and 21 subjects with obesity and metabolic syndrome (OBM). We measured 754 well-characterized human microRNAs (miRNAs) and identified differentially expressed miRNAs along with their significant associations with clinical markers in these patients.
+
+ Results: A total of 64 miRNAs were differentially expressed between metabolically healthy obese (OBO) versus metabolically unhealthy obese (OBM) patients. Thirteen out of 64 miRNAs significantly correlated with at least one clinical trait of the metabolic syndrome. Six out of the thirteen demonstrated significant association with HbA1c levels; miR-331-3p, miR-452-3p, and miR-485-5p were over-expressed, whereas miR-153-3p, miR-182-5p, and miR-433-3p were under-expressed in the OBM patients with elevated HbA1c levels. We also identified, miR-106b-3p, miR-652-3p, and miR-93-5p that showed a significant association with creatinine; miR-130b-5p, miR-363-3p, and miR-636 were significantly associated with cholesterol, whereas miR-130a-3p was significantly associated with LDL. Additionally, miR-652-3p's differential expression correlated significantly with HDL and creatinine.
+
+ Conclusions: MicroRNAs associated with metabolic syndrome in obese subjects may have a pathophysiologic role and can serve as markers for obese individuals predisposed to various metabolic diseases like diabetes. Copyright © 2022 Mir, Mall, Iskandarani, Ullah, Samra, Cyprian, Parray, Alkasem, Abdalhakam, Farooq and Abou-Samra.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (MIRN153 microRNA, human). 0 (MIRN363 microRNA, human). 0 (MIRN433 microRNA, human). 0 (MIRN485 microRNA, human). 0 (MicroRNAs). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.937089
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mir&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Characteristic+MicroRNAs+Linked+to+Dysregulated+Metabolic+Pathways+in+Qatari+Adult+Subjects+With+Obesity+and+Metabolic+Syndrome.&volume=13&issue=&spage=937089&epage=&date=2022&doi=10.3389%2Ffendo.2022.937089&pmid=35937842&sid=OVID:medline
+
+<437>
+Unique Identifier
+ 35933054
+Title
+ Dietary antioxidant intake is inversely associated with 2,3-dinor oxylipin metabolites, the major excreted oxylipins in overweight and obese subjects.
+Source
+ Free Radical Biology & Medicine. 190:42-54, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lara-Guzman OJ; Rivera DA; Corrales-Agudelo V; Salazar-Jaramillo L; Gil-Izquierdo A; Medina S; Oger C; Durand T; Galano JM; Escobar JS; Munoz-Durango K; Sierra JA
+Authors Full Name
+ Lara-Guzman, Oscar J; Rivera, Diego A; Corrales-Agudelo, Vanessa; Salazar-Jaramillo, Laura; Gil-Izquierdo, Angel; Medina, Sonia; Oger, Camille; Durand, Thierry; Galano, Jean-Marie; Escobar, Juan S; Munoz-Durango, Katalina; Sierra, Jelver A.
+Institution
+ Lara-Guzman, Oscar J. Vidarium-Nutrition, Health and Wellness Research Center, Grupo Empresarial Nutresa, Calle 8 sur No. 50-67, Medellin, Colombia.
+ Rivera, Diego A. Vidarium-Nutrition, Health and Wellness Research Center, Grupo Empresarial Nutresa, Calle 8 sur No. 50-67, Medellin, Colombia.
+ Corrales-Agudelo, Vanessa. Vidarium-Nutrition, Health and Wellness Research Center, Grupo Empresarial Nutresa, Calle 8 sur No. 50-67, Medellin, Colombia.
+ Salazar-Jaramillo, Laura. Vidarium-Nutrition, Health and Wellness Research Center, Grupo Empresarial Nutresa, Calle 8 sur No. 50-67, Medellin, Colombia.
+ Gil-Izquierdo, Angel. Research Group on Quality, Safety, and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100, Campus University Espinardo, Murcia, Spain.
+ Medina, Sonia. Research Group on Quality, Safety, and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100, Campus University Espinardo, Murcia, Spain.
+ Oger, Camille. Institut des Biomolecules Max Mousseron (IBMM), Pole Chimi Balard recherche, UMR 5247, CNRS, University of Montpellier, ENSCM, 1919 route de Mende, 34093, Montpellier, France.
+ Durand, Thierry. Institut des Biomolecules Max Mousseron (IBMM), Pole Chimi Balard recherche, UMR 5247, CNRS, University of Montpellier, ENSCM, 1919 route de Mende, 34093, Montpellier, France.
+ Galano, Jean-Marie. Institut des Biomolecules Max Mousseron (IBMM), Pole Chimi Balard recherche, UMR 5247, CNRS, University of Montpellier, ENSCM, 1919 route de Mende, 34093, Montpellier, France.
+ Escobar, Juan S. Vidarium-Nutrition, Health and Wellness Research Center, Grupo Empresarial Nutresa, Calle 8 sur No. 50-67, Medellin, Colombia.
+ Munoz-Durango, Katalina. Vidarium-Nutrition, Health and Wellness Research Center, Grupo Empresarial Nutresa, Calle 8 sur No. 50-67, Medellin, Colombia. Electronic address: kmunoz@serviciosnutresa.com.
+ Sierra, Jelver A. Vidarium-Nutrition, Health and Wellness Research Center, Grupo Empresarial Nutresa, Calle 8 sur No. 50-67, Medellin, Colombia. Electronic address: jsierra@serviciosnutresa.com.
+MeSH Subject Headings
+ Adult
+ *Antioxidants
+ Biomarkers
+ *Cardiovascular Diseases
+ F2-Isoprostanes/me [Metabolism]
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ Overweight
+ Oxylipins
+ Polyphenols
+ Tandem Mass Spectrometry
+Keyword Heading
+ Biomarkers
+ Dietary antioxidants
+ Inflammation
+ Obesity
+ Oxidative stress
+ Oxylipins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cardiometabolic disease risk factors, including obesity, insulin resistance, high blood pressure, and dyslipidemia, are associated with elevated oxidative stress biomarkers like oxylipins. Increased adiposity by itself induces various isomers of this oxidized lipid family, while dietary polyphenols show benefits in its regulation. Previously, we showed that specific co-abundant microorganisms characterized the gut microbiota of Colombians and associated differentially with diet, lifestyle, obesity, and cardiometabolic health status, which led us to hypothesize that urinary oxylipins would reflect the intensity of oxidative metabolism linked to gut microbiota dysbiosis. Thus, we selected a convenience sample of 105 participants (age: 40.2 +/- 11.9 years, 47.6% women), grouped according to microbiota, cardiometabolic health status, and body mass index (BMI); and evaluated 33 urinary oxylipins by HPLC-QqQ-MS/MS (e.g., isoprostanes, prostaglandins, and metabolites), paired with anthropometry and blood chemistry information and dietary antioxidants estimated from a 24-h food recall. In general, oxylipins did not show differences among individuals who differed in gut microbiota. While the unmetabolized oxylipin levels were not associated with BMI, the total content of oxylipin metabolites was highest in obese and cardiometabolically abnormal subjects (e.g., insulin resistant), mainly by prostaglandin-D (2,3-dinor-11beta-PGF2alpha) and 15-F2t-IsoPs (2,3-dinor-15-F2t-IsoP and 2,3-dinor-15-epi-15-F2t-IsoP) metabolites. The total polyphenol intake in this cohort was 1070 +/- 627 mg/day. After adjusting for body weight, the polyphenol intake was significantly higher in lean than overweight and showed an inverse association with dinor-oxylipin levels in principal component analysis. These results suggest that the 2,3-dinor-oxylipins could be more specific biomarkers associated with BMI than their parent oxylipins and that are sensitive to be regulated by dietary antioxidants. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (F2-Isoprostanes). 0 (Oxylipins). 0 (Polyphenols).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.freeradbiomed.2022.07.023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lara-Guzman&issn=0891-5849&title=Free+Radical+Biology+%26+Medicine&atitle=Dietary+antioxidant+intake+is+inversely+associated+with+2%2C3-dinor+oxylipin+metabolites%2C+the+major+excreted+oxylipins+in+overweight+and+obese+subjects.&volume=190&issue=&spage=42&epage=54&date=2022&doi=10.1016%2Fj.freeradbiomed.2022.07.023&pmid=35933054&sid=OVID:medline
+
+<438>
+Unique Identifier
+ 35924930
+Title
+ Longitudinal association between caesarean section birth and cardio-vascular risk profiles among adolescents in Australia.
+Source
+ Australian & New Zealand Journal of Public Health. 46(6):776-783, 2022 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Begum T; Fatima Y; Anuradha S; Hasan M; Mamun AA
+Authors Full Name
+ Begum, Tahmina; Fatima, Yaqoot; Anuradha, Satyamurthy; Hasan, Md; Mamun, Abdullah Al.
+Institution
+ Begum, Tahmina. Institute for Social Science Research, The University of Queensland, Queensland.
+ Begum, Tahmina. ARC Centre of Excellence for Children and Families over the Life Course Centre, The University of Queensland, Queensland.
+ Fatima, Yaqoot. Institute for Social Science Research, The University of Queensland, Queensland.
+ Fatima, Yaqoot. Murtupuni Centre for Rural and Remote Health, James Cook University, Mount Isa, Queensland.
+ Anuradha, Satyamurthy. Public health medicine, Queensland Health.
+ Hasan, Md. Department of Public Health and Informatics, BSMMU, Bangladesh.
+ Mamun, Abdullah Al. Institute for Social Science Research, The University of Queensland, Queensland.
+ Mamun, Abdullah Al. ARC Centre of Excellence for Children and Families over the Life Course Centre, The University of Queensland, Queensland.
+MeSH Subject Headings
+ Child
+ Adolescent
+ Female
+ Humans
+ Pregnancy
+ Male
+ *Cesarean Section
+ Longitudinal Studies
+ Obesity
+ Risk Factors
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Australia/ep [Epidemiology]
+ Waist Circumference/ph [Physiology]
+ Body Mass Index
+ Biomarkers
+Keyword Heading
+ adolescents
+ caesarean section birth
+ cardiovascular risk
+ continuous metabolic syndrome score
+ developed country
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To examine the association of cesarean section (C-section) with cardiovascular disease (CVD) risk biomarkers among Australian children.
+
+ METHODS: The Longitudinal Study of Australian Children (LSAC) birth cohort was prospectively followed for body mass index (BMI) trajectory, and then linked with CVD risk indicators of children; waist circumference (WC), systolic blood pressure (SBP), blood glucose, high-density lipoprotein (HDL), triglyceride (TG), fat mass index (FMI) and composite metabolic syndrome (CMetS) score. Multivariable linear regression analysis was done to assess the association of C-sections with CVD risk biomarkers.
+
+ RESULTS: Of 1,874 study children, 30% had C-sections; the mean age (SD) was 11.50 (0.50) years, and 49% were female. Against the vaginally-born cohort, Caesarean-born children showed a higher Z- score for five of the seven CVD risk indicators in regression analysis; WC (0.15; p=0.003), SBP (0.16; p=0.003), inverse HDL (0.15; p=0.003), FMI (0.12; p=0.004), and CMetS (0.45; p=0.004) score. Children with accelerated BMI trajectory had higher CMetS scores for both the delivery types while the C-section cohort showed statistical association only (1.69; p=0.006) Conclusion: C-section was independently associated with increased CVD risk profiles of children, further increased with high BMI trajectory. Implication for public health: The chronic disease risk of C-sections should be discussed with families to reduce clinically unrequired C-sections. Copyright © 2022 The Authors.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2f1753-6405.13288
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Begum&issn=1326-0200&title=Australian+%26+New+Zealand+Journal+of+Public+Health&atitle=Longitudinal+association+between+caesarean+section+birth+and+cardio-vascular+risk+profiles+among+adolescents+in+Australia.&volume=46&issue=6&spage=776&epage=783&date=2022&doi=10.1111%2F1753-6405.13288&pmid=35924930&sid=OVID:medline
+
+<439>
+Unique Identifier
+ 35911732
+Title
+ An evidence review of the association of immune and inflammatory markers with obesity-related eating behaviors.
+Source
+ Frontiers in Immunology. 13:902114, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Meng Y; Kautz A
+Authors Full Name
+ Meng, Ying; Kautz, Amber.
+Institution
+ Meng, Ying. School of Nursing, University of Rochester, Rochester, NY, United States.
+ Kautz, Amber. Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, United States.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cross-Sectional Studies
+ *Feeding Behavior
+ Humans
+ Inflammation
+ *Obesity
+Keyword Heading
+ cytokine
+ eating behavior
+ immune markers
+ inflammatory marker
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Eating behaviors contribute to disproportionate energy intake and are linked to the development of obesity. Animal studies support the role of inflammatory cytokines and chemokines in the regulation of obesity-related eating behaviors and offer a potential target to combat obesity through the modulation of inflammation. However, more complex eating behaviors are present in humans, and their relationships with immune/inflammation markers are unclear. The present study reviewed current literature to synthesize the evidence on the association of immune/inflammation markers with obesity-related eating behaviors in humans.
+
+ Methods: A systematic search of three electronic databases yielded 811 articles, of which 11 met the inclusion criteria.
+
+ Results: The majority of the included studies (91%) were either case-control or cross-sectional studies. A variety of immune/inflammation markers and obesity-related eating behaviors have been assessed in the chosen studies. Three out of four studies identified a positive relationship between C-reactive protein (CRP)/high-sensitivity CRP and loss of control eating. Other inflammatory markers that potentially have a positive relationship with obesity-related eating behaviors include fractalkine and fibrinogen. Additionally, immune molecules, including interferon gamma (INF-gamma), interleukin (IL)-7, IL-10, and alpha-melanocyte-stimulating hormone-reactive immunoglobulin G (alpha-MSH/IgG) immune complex, may have negative associations with obesity-related eating behaviors. However, most findings were identified by single studies.
+
+ Conclusion: Limited studies have been conducted in humans. Current evidence indicates a potential bi-directional relationship between inflammatory/immune markers and obesity-related eating behaviors. Additional studies with sophisticated research design and comprehensive theoretical models are warranted to further delineate the relationship between immune/inflammation markers and obesity-related eating behaviors. Copyright © 2022 Meng and Kautz.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Systematic Review. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffimmu.2022.902114
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Meng&issn=1664-3224&title=Frontiers+in+Immunology&atitle=An+evidence+review+of+the+association+of+immune+and+inflammatory+markers+with+obesity-related+eating+behaviors.&volume=13&issue=&spage=902114&epage=&date=2022&doi=10.3389%2Ffimmu.2022.902114&pmid=35911732&sid=OVID:medline
+
+<440>
+Unique Identifier
+ 35909516
+Title
+ Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women.
+Source
+ Frontiers in Endocrinology. 13:918320, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ramanjaneya M; Diboun I; Rizwana N; Dajani Y; Ahmed L; Butler AE; Almarzooqi TA; Shahata M; Al Bader MK; Elgassim E; Burjaq H; Atkin SL; Abou-Samra AB; Elrayess MA
+Authors Full Name
+ Ramanjaneya, Manjunath; Diboun, Ilhame; Rizwana, Najeha; Dajani, Yaser; Ahmed, Lina; Butler, Alexandra E; Almarzooqi, Thoraya Ali; Shahata, Mohammed; Al Bader, Moza Khalaf; Elgassim, Einas; Burjaq, Hasan; Atkin, Stephen L; Abou-Samra, Abdul-Badi; Elrayess, Mohamed A.
+Institution
+ Ramanjaneya, Manjunath. Qatar Metabolic Institute, Hamad Medical Corporation, Doha, Qatar.
+ Ramanjaneya, Manjunath. Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.
+ Diboun, Ilhame. College of Health and Life sciences, Doha, Qatar.
+ Rizwana, Najeha. Biomedical Research Center (BRC), Qatar University, Doha, Qatar.
+ Dajani, Yaser. Reproductive Medicine, Doha, Qatar.
+ Ahmed, Lina. Department of Medicine, Doha, Qatar.
+ Butler, Alexandra E. Post Graduate Studies and Research, Adliya, Bahrain.
+ Almarzooqi, Thoraya Ali. Obstetrics and Gynecology Department, Women's Hospital, Hamad Medical Corporation, Doha, Qatar.
+ Shahata, Mohammed. Obstetrics and Gynecology Department, Women's Hospital, Hamad Medical Corporation, Doha, Qatar.
+ Al Bader, Moza Khalaf. Obstetrics and Gynecology Department, Women's Hospital, Hamad Medical Corporation, Doha, Qatar.
+ Elgassim, Einas. Department of Medicine, Doha, Qatar.
+ Burjaq, Hasan. Obstetrics and Gynecology Department, Women's Hospital, Hamad Medical Corporation, Doha, Qatar.
+ Atkin, Stephen L. Post Graduate Studies and Research, Adliya, Bahrain.
+ Abou-Samra, Abdul-Badi. Qatar Metabolic Institute, Hamad Medical Corporation, Doha, Qatar.
+ Elrayess, Mohamed A. Biomedical Research Center (BRC), Qatar University, Doha, Qatar.
+ Elrayess, Mohamed A. QU Health, Qatar University, Doha, Qatar.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Complement C5a/me [Metabolism]
+ *Complement C5a
+ Complement Factor D/me [Metabolism]
+ *Complement Factor D
+ Female
+ Follicular Fluid/me [Metabolism]
+ *Follicular Fluid
+ Humans
+ Obesity/me [Metabolism]
+ Overweight/me [Metabolism]
+ Pregnancy
+ Pregnancy Outcome
+ Properdin/me [Metabolism]
+Keyword Heading
+ adipsin
+ complement factors
+ embryos
+ follicular fluid (FF)
+ in vitro fertilization (IVF)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction: Complement factors mediate the recruitment and activation of immune cells and are associated with metabolic changes during pregnancy. The aim of this study was to determine whether complement factors in the maternal serum and follicular fluid (FF) are associated with in vitro fertilization (IVF) outcomes in overweight/obese women.
+
+ Methods: Forty overweight/obese (BMI = 30.8 +/- 5.2 kg/m2) female patients, 33.6 +/- 6.3 years old, undergoing IVF treatment for unexplained infertility were recruited. Baseline demographic information, including biochemical hormonal, metabolic, and inflammatory markers, and pregnancy outcome, was collected. Levels of 14 complement markers (C2, C4b, C5, C5a, C9, adipsin, mannose-binding lectin, C1q, C3, C3b/iC3b, C4, factor B, factor H, and properdin) were assessed in the serum and FF and compared to IVF outcome, inflammatory, and metabolic markers using multivariate and univariate models.
+
+ Results: Out of 40 IVF cycles, 14 (35%) resulted in pregnancy. Compared to women with failed pregnancies, women with successful pregnancies had higher levels of adipsin in the serum and FF (p = 0.01) but lower C5a levels (p = 0.05). Serum adipsin levels were positively correlated with circulating levels of vitamin D (R = 0.5, p = 0.02), glucagon (R = 0.4, p = 0.03), leptin (R = 0.4, p = 0.01), resistin (R = 0.4, p = 0.02), and visfatin (R = 0.4, p = 0.02), but negatively correlated with total protein (R = -0.5, p = 0.03). Higher numbers of top-quality embryos were associated with increased levels of C3, properdin, C1q, factors H and B, C4, and adipsin, but with reduced C2 and C5a levels (p <= 0.01).
+
+ Conclusions: Higher adipsin and lower C5a levels in the maternal serum during implantation are potential markers of successful outcome in obese women undergoing IVF-assisted pregnancies. Copyright © 2022 Ramanjaneya, Diboun, Rizwana, Dajani, Ahmed, Butler, Almarzooqi, Shahata, Al Bader, Elgassim, Burjaq, Atkin, Abou-Samra and Elrayess.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 11016-39-0 (Properdin). 80295-54-1 (Complement C5a). EC 3-4-21-46 (Complement Factor D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.918320
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ramanjaneya&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Elevated+Adipsin+and+Reduced+C5a+Levels+in+the+Maternal+Serum+and+Follicular+Fluid+During+Implantation+Are+Associated+With+Successful+Pregnancy+in+Obese+Women.&volume=13&issue=&spage=918320&epage=&date=2022&doi=10.3389%2Ffendo.2022.918320&pmid=35909516&sid=OVID:medline
+
+<441>
+Unique Identifier
+ 35907970
+Title
+ The correlation of plasma atherogenic index and obesity in patients with familial Mediterranean fever.
+Source
+ Clinical Rheumatology. 41(11):3471-3477, 2022 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gogebakan H; Kasali K
+Author NameID
+ Gogebakan, Hasan; ORCID: http://orcid.org/0000-0002-3448-4838
+ Kasali, Kamber; ORCID: http://orcid.org/0000-0002-2851-5263
+Authors Full Name
+ Gogebakan, Hasan; Kasali, Kamber.
+Institution
+ Gogebakan, Hasan. Department of Internal Medicine, Division of Rheumatology, Health Sciences University Erzurum Regional Education and Research Hospital, Erzurum, Turkey. drgogebakan@hotmail.com.
+ Kasali, Kamber. Department of Biostatistics, School of Medicine, Ataturk University, Erzurum, Turkey.
+MeSH Subject Headings
+ Biomarkers
+ *Cardiovascular Diseases
+ Cholesterol, HDL
+ Cholesterol, LDL
+ Cross-Sectional Studies
+ *Familial Mediterranean Fever
+ Humans
+ Lipids
+ Obesity/co [Complications]
+ Triglycerides
+Keyword Heading
+ Familial Mediterranean fever
+ Obesity
+ Plasma atherogenic index
+ Triglycerides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The plasma atherogenic index (PAI) is associated with cardiovascular diseases. This study evaluated the relationship between PAI and obesity in patients with familial Mediterranean fever (FMF) and its advantage over conventional lipid components in predicting obesity.
+
+ METHODS: The cross-sectional study included 164 FMF patients in the attack-free period and a control group of 160 healthy individuals. Serum lipid components were measured, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). PAI was calculated as log 10 (TG/HDL-C). The relationship between PAI, four conventional lipid profiles, and obesity was evaluated.
+
+ RESULTS: The mean PAI values (p = 0.003), frequency of obesity (p = 0.005), TC (p = 0.008), TG (p = 0.000), and LDL-C (p = 0.005) values were determined to be statistically significantly higher in the FMF patients than in the control group. The FMF patients with a higher PAI value had a higher risk of obesity, systolic and diastolic blood pressure, TC, and LDL-C, and lower HDL-C (p < 0.001). The Pearson coefficient for PAI (r = 0.854; p < 0.001) was calculated as an explanatory percentage on the variable of obesity of r2 = 0.730. There was a stronger relationship between obesity and PAI than conventional lipid components (p < 0.001).
+
+ CONCLUSION: We have found that the PAI, BMI, TC, TG, and LDL-C values of the FMF patients were determined to be higher. The higher PAI was strongly correlated to obesity in FMF patients. The first time in FMF patients, PAI showed increased sensitivity to predict obesity, higher than conventional lipid components. It can be a promising biomarker for obesity compared to other lipid components. A low-cost and readily available index derived from routine (TG and HDL-C) tests are advantages in identifying obesity in FMF patients. Key Points * The PAI is valuable for atherosclerotic CVD risk management in patients with rheumatismal diseases. * A correlation is found between PAI level and obesity, and it is used as a biomarker for obesity in the healthy population. * The PAI revealed increased sensitivity to predict obesity, higher than conventional lipid components in FMF patients. Copyright © 2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Lipids). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs10067-022-06312-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gogebakan&issn=0770-3198&title=Clinical+Rheumatology&atitle=The+correlation+of+plasma+atherogenic+index+and+obesity+in+patients+with+familial+Mediterranean+fever.&volume=41&issue=11&spage=3471&epage=3477&date=2022&doi=10.1007%2Fs10067-022-06312-x&pmid=35907970&sid=OVID:medline
+
+<442>
+Unique Identifier
+ 35905889
+Title
+ Haptoglobin polymorphism modulates cardiometabolic impacts of four consecutive weeks, dawn to sunset Ramadan intermittent fasting among subjects with overweight/obesity.
+Source
+ Diabetes Research & Clinical Practice. 190:110024, 2022 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Madkour MI; Hassan RE; Sherif NM; Awadallah S; Abdelrahim DN; Jahrami HA; Abu Shihab K; Faris ME
+Authors Full Name
+ Madkour, Mohamed I; Hassan, Rasha E; Sherif, Naglaa M; Awadallah, Samir; Abdelrahim, Dana N; Jahrami, Haitham A; Abu Shihab, Katia; Faris, MoezAlIslam E.
+Institution
+ Madkour, Mohamed I. Department of Medical Laboratory Sciences, College of Health Sciences/Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates.
+ Hassan, Rasha E. Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
+ Sherif, Naglaa M. Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
+ Awadallah, Samir. Department of Medical Laboratories, College of Allied Medical Sciences, Zarqa University, Zarqa, Jordan.
+ Abdelrahim, Dana N. Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates; Department of Clinical Nutrition and Dietetics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.
+ Jahrami, Haitham A. Ministry of Health, Bahrain; College of Medicine and Medical Sciences, Arabian Gulf University, Bahrain.
+ Abu Shihab, Katia. Department of Clinical Nutrition and Dietetics, College of Health Sciences/Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates.
+ Faris, MoezAlIslam E. Department of Clinical Nutrition and Dietetics, College of Health Sciences/Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates. Electronic address: mfaris@sharjah.ac.ae.
+MeSH Subject Headings
+ Biomarkers
+ Cardiovascular Diseases/ge [Genetics]
+ *Cardiovascular Diseases
+ Fasting
+ Female
+ Haptoglobins/ge [Genetics]
+ *Haptoglobins
+ Humans
+ Inflammation/ge [Genetics]
+ Male
+ Obesity/ep [Epidemiology]
+ Overweight/ge [Genetics]
+ Polymorphism, Genetic/ge [Genetics]
+ Triglycerides
+ Tumor Necrosis Factor-alpha/ge [Genetics]
+Keyword Heading
+ Inflammation
+ Nucleotide Polymorphisms (SNPs)
+ Nutrigenomics
+ Oxidative stress
+ Personalized nutrition
+ Ramadan
+ Time-restricted eating
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Haptoglobin (Hp) is a multifaceted marker of inflammation, and mediates the interplay between obesity, inflammation, and cardiometabolic dysfunction. However, the role of the Hp phenotype in modulating intermittent fasting (IF)-induced cardiometabolic changes remains to be elucidated.
+
+ METHODS: Hp phenotype was determined for the study subjects. Cardiometabolic markers were assessed before and at the end of four consecutive weeks, dawn to sunset IF.
+
+ RESULTS: A total of 114 subjects (75 males and 39 females, 38.7 +/- 11.7 years, body mass index (BMI) of 30.41 +/- 5.09 kg/m2) were recruited. Hp2-2 (n = 55, 48.2 %) and Hp2-1 (n = 53, 46.5 %) were the predominant phenotypes. Significant reductions were observed in serum Hp, IL-6, TNF-alpha, triglycerides (TG), total cholesterol (TC), LDL, BMI, and fat mass (FM), while a significant elevation was observed in serum CD163, HDL, and IL-10 at the end of the IF month for the whole population. Based on the Hp polymorphism, significant decreases in Hp, BMI, FM, TG, LDL, and TNF-alpha, with significant increases in HDL and CD163 levels were observed among subjects with Hp2-2 and Hp2-1 phenotypes. A more pronounced reduction in FM was reported in subjects with Hp2-2 in comparison with Hp2-1.
+
+ CONCLUSION: Hp gene polymorphism modulates IF-induced changes in cardiometabolic markers.
+
+ CLINICAL TRIAL REGISTRATION NUMBER: ISRCTN18205186; https://trialsearch.who.int/?TrialID=ISRCTN18205186. Copyright © 2022 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Haptoglobins). 0 (Triglycerides). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.diabres.2022.110024
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Madkour&issn=0168-8227&title=Diabetes+Research+%26+Clinical+Practice&atitle=Haptoglobin+polymorphism+modulates+cardiometabolic+impacts+of+four+consecutive+weeks%2C+dawn+to+sunset+Ramadan+intermittent+fasting+among+subjects+with+overweight%2Fobesity.&volume=190&issue=&spage=110024&epage=&date=2022&doi=10.1016%2Fj.diabres.2022.110024&pmid=35905889&sid=OVID:medline
+
+<443>
+Unique Identifier
+ 35893925
+Title
+ The Effects of Intermittent Fasting and Continuous Energy Restriction with Exercise on Cardiometabolic Biomarkers, Dietary Compliance, and Perceived Hunger and Mood: Secondary Outcomes of a Randomised, Controlled Trial.
+Source
+ Nutrients. 14(15), 2022 Jul 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Keenan S; Cooke MB; Chen WS; Wu S; Belski R
+Author NameID
+ Cooke, Matthew B; ORCID: https://orcid.org/0000-0002-4978-4294
+ Chen, Won Sun; ORCID: https://orcid.org/0000-0001-9077-3530
+Authors Full Name
+ Keenan, Stephen; Cooke, Matthew B; Chen, Won Sun; Wu, Sam; Belski, Regina.
+Institution
+ Keenan, Stephen. School of Health Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
+ Cooke, Matthew B. School of Health Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
+ Chen, Won Sun. School of Health Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
+ Wu, Sam. School of Health Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
+ Belski, Regina. School of Health Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
+ Belski, Regina. School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, VIC 3086, Australia.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Caloric Restriction/mt [Methods]
+ *Cardiovascular Diseases
+ Cholesterol, LDL
+ Diet
+ *Fasting
+ Female
+ Humans
+ Hunger
+ Male
+ Obesity
+ Weight Loss/ph [Physiology]
+ Young Adult
+Keyword Heading
+ cardiometabolic
+ compliance
+ continuous energy restriction
+ intermittent fasting
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ (1) Background: Excess weight in the form of adiposity plays a key role in the pathogenesis of cardiometabolic diseases. Lifestyle modifications that incorporate continuous energy restriction (CER) are effective at inducing weight loss and reductions in adiposity; however, prescribing daily CER results in poor long-term adherence. Over the past decade, intermittent fasting (IF) has emerged as a promising alternative to CER that may promote increased compliance and/or improvements in cardiometabolic health parameters independent of weight loss. (2) Methods: This paper presents a secondary analysis of data from a 12-week intervention investigating the effects of a twice-weekly fast (5:2 IF; IFT group) and CER (CERT group) when combined with resistance exercise in 34 healthy participants (17 males and 17 females, mean BMI: 27.0 kg/m2, mean age: 23.9 years). Specifically, changes in cardiometabolic blood markers and ratings of hunger, mood, energy and compliance within and between groups were analysed. Dietary prescriptions were hypoenergetic and matched for energy and protein intake. (3) Results: Both dietary groups experienced reductions in total cholesterol (TC; mean reduction, 7.8%; p < 0.001), low-density lipoprotein cholesterol (LDL-C; mean reduction, 11.1%; p < 0.001) and high-density lipoprotein cholesterol (mean reduction 2.6%, p = 0.049) over the 12 weeks. Reductions in TC and LDL-C were greater in the IFT group after adjustment for baseline levels and change in weight. No significant changes in markers of glucose regulation were observed. Both groups maintained high levels of dietary compliance (~80%) and reported low levels of hunger over the course of the intervention period. (4) Conclusions: Secondary data analysis revealed that when combined with resistance training, both dietary patterns improved blood lipids, with greater reductions observed in the IFT group. High levels of compliance and low reported levels of hunger throughout the intervention period suggest both diets are well tolerated in the short-to-medium term.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14153071
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Keenan&issn=2072-6643&title=Nutrients&atitle=The+Effects+of+Intermittent+Fasting+and+Continuous+Energy+Restriction+with+Exercise+on+Cardiometabolic+Biomarkers%2C+Dietary+Compliance%2C+and+Perceived+Hunger+and+Mood%3A+Secondary+Outcomes+of+a+Randomised%2C+Controlled+Trial.&volume=14&issue=15&spage=&epage=&date=2022&doi=10.3390%2Fnu14153071&pmid=35893925&sid=OVID:medline
+
+<444>
+Unique Identifier
+ 35889957
+Title
+ Urinary Sodium Excretion and Obesity Markers among Bangladeshi Adult Population: Pooled Data from Three Cohort Studies.
+Source
+ Nutrients. 14(14), 2022 Jul 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rahman MJ; Parvez SM; Rahman M; He FJ; Cunningham SA; Narayan KMV; Abedin J; Naser AM
+Author NameID
+ Parvez, Sarker M; ORCID: https://orcid.org/0000-0003-2004-5065
+ Rahman, Mahbubur; ORCID: https://orcid.org/0000-0003-0520-2683
+ He, Feng J; ORCID: https://orcid.org/0000-0003-2807-4119
+ Cunningham, Solveig A; ORCID: https://orcid.org/0000-0002-2354-1526
+Authors Full Name
+ Rahman, Musarrat J; Parvez, Sarker M; Rahman, Mahbubur; He, Feng J; Cunningham, Solveig A; Narayan, K M Venkat; Abedin, Jaynal; Naser, Abu Mohd.
+Institution
+ Rahman, Musarrat J. International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
+ Parvez, Sarker M. Environmental Interventions Unit, Infectious Disease Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, Bangladesh.
+ Rahman, Mahbubur. Environmental Interventions Unit, Infectious Disease Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, Bangladesh.
+ He, Feng J. Centre for Public Health and Policy, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
+ Cunningham, Solveig A. Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
+ Narayan, K M Venkat. Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
+ Abedin, Jaynal. Data Science Institute, National University of Ireland Galway, H91 TK33 Galway, Ireland.
+ Naser, Abu Mohd. Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Mass Index
+ Cohort Studies
+ Humans
+ Obesity/ep [Epidemiology]
+ *Obesity
+ *Sodium
+ Waist Circumference
+Keyword Heading
+ body mass index
+ obesity
+ sodium intake
+ urine sodium
+ waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We evaluated the relationship of urinary sodium excretion with a conditional mean, 10th and 90th percentiles of body mass index (BMI), and waist circumference among 10,034 person-visits of Bangladeshi population. We fitted linear mixed models with participant-level random intercept and restricted maximum likelihood estimation for conditional mean models; and quantile mixed-effect models with participant-level random intercept and Laplace estimation for 10th and 90th percentiles models. For each 100 mmol/24 h increase in urinary sodium excretion, participants had a 0.10 kg/m2 (95% CI: 0.00, 0.10) increase in the mean; a 0.39 kg/m2 (95% CI: 0.23, 0.54) increase in the 10th percentile; and a 0.59 kg/m2 (95% CI: 0.39, 0.78) increase in the 90th percentile of BMI. For each 100 mmol/24 h increase in urinary sodium excretion, participants had a 0.20 cm (95% CI: 0.10, 0.30) increase in mean; a 0.18 cm (95% CI: -0.03, 0.40) change in the 10th percentile; and a 0.23 cm (95% CI: 0.03, 0.43) increase in the 90th percentile of waist circumference. We found a modest association between urine sodium and conditional mean of BMI and waist circumference. The magnitude of associations between urine sodium and the 10th and 90th percentile BMI distributions were higher compared to the conditional mean models, suggesting high sodium intake could be more detrimental to underweight and obese participants.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9NEZ333N27 (Sodium).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14143000
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rahman&issn=2072-6643&title=Nutrients&atitle=Urinary+Sodium+Excretion+and+Obesity+Markers+among+Bangladeshi+Adult+Population%3A+Pooled+Data+from+Three+Cohort+Studies.&volume=14&issue=14&spage=&epage=&date=2022&doi=10.3390%2Fnu14143000&pmid=35889957&sid=OVID:medline
+
+<445>
+Unique Identifier
+ 35889949
+Title
+ Gut Microbiota Characteristics of People with Obesity by Meta-Analysis of Existing Datasets.
+Source
+ Nutrients. 14(14), 2022 Jul 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gong J; Shen Y; Zhang H; Cao M; Guo M; He J; Zhang B; Xiao C
+Author NameID
+ Gong, Jinhua; ORCID: https://orcid.org/0000-0001-8560-3182
+Authors Full Name
+ Gong, Jinhua; Shen, Yun; Zhang, Hongcheng; Cao, Man; Guo, Muyun; He, Jianquan; Zhang, Bangzhou; Xiao, Chuanxing.
+Institution
+ Gong, Jinhua. School of Medicine, Xiamen University, Xiamen 361102, China.
+ Shen, Yun. Sport Hospital Attached of ChengDu Sport University, Chengdu 610041, China.
+ Zhang, Hongcheng. Xiamen Treatgut Biotechnology Co., Ltd., Xiamen 361101, China.
+ Cao, Man. Xiamen Treatgut Biotechnology Co., Ltd., Xiamen 361101, China.
+ Guo, Muyun. Pulmonary and Critical Care Medicine, Anyang District Hospital, Anyang 456000, China.
+ He, Jianquan. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
+ He, Jianquan. Department of Rehabilitation, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China.
+ Zhang, Bangzhou. School of Medicine, Xiamen University, Xiamen 361102, China.
+ Zhang, Bangzhou. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
+ Xiao, Chuanxing. School of Medicine, Xiamen University, Xiamen 361102, China.
+ Xiao, Chuanxing. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
+ Xiao, Chuanxing. Department of Gastroenterology, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China.
+MeSH Subject Headings
+ Bacteria
+ Biomarkers/me [Metabolism]
+ Feces/mi [Microbiology]
+ *Gastrointestinal Microbiome
+ Humans
+ Obesity/mi [Microbiology]
+ Overweight
+ RNA, Ribosomal, 16S/me [Metabolism]
+Keyword Heading
+ 16S rRNA
+ BMI
+ gut microbiota
+ humans
+ meta-analysis
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a complex chronic, relapsing, progressive disease. Association studies have linked microbiome alterations with obesity and overweight. However, the results are not always consistent. An integrated analysis of 4282 fecal samples (2236 control (normal weight) group, 1152 overweight, and 894 simple obesity) was performed to identify obesity-associated microbial markers. Based on a random effects model and a fixed effects model, we calculated the odds ratios of the metrics, including bacterial alpha-diversity, beta-diversity, Bacteroidetes/Firmicutes ratio, common genera, and common pathways, between the simple obesity and control groups as well as the overweight and control groups. The random forest model was trained based on a single dataset at the genus level. Feature selection based on feature importance ranked by mean decrease accuracy and leave-one-out cross-validation was conducted to improve the predictive performance of the models. Chao1 and evenness possessed significant ORs higher than 1.0 between the obesity and control groups. Significant bacterial community differences were observed between the simple obesity and the control. The ratio of Bacteroidetes/Firmicutes was significantly higher in simple obesity patients. The relative abundance of Lachnoclostridium and Faecalitalea were higher in people with simple obesity, while 23 genera, including Christensenellaceae_R-7_group, Akkermansia, Alistipes, and Butyricimonas, etc., were significantly lower. The random forest model achieved a high accuracy (AUC = 0.83). The adenine and adenosine salvage pathway (PWY-6609) and the L-histidine degradation I pathway (HISDEG-PWY) were clustered in obese patients, while amino acid biosynthesis and degradation pathways (HISDEG-PWY, DAPLYSINESYN-PWY) were decreased. This study identified obesity microbial biomarkers, providing fertile targets for the management of obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Ribosomal, 16S).
+Publication Type
+ Journal Article. Meta-Analysis.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14142993
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gong&issn=2072-6643&title=Nutrients&atitle=Gut+Microbiota+Characteristics+of+People+with+Obesity+by+Meta-Analysis+of+Existing+Datasets.&volume=14&issue=14&spage=&epage=&date=2022&doi=10.3390%2Fnu14142993&pmid=35889949&sid=OVID:medline
+
+<446>
+Unique Identifier
+ 35889925
+Title
+ Comparison of Pulmonary Function and Inflammation in Children/Adolescents with New-Onset Asthma with Different Adiposity Statuses.
+Source
+ Nutrients. 14(14), 2022 Jul 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ying X; Lin J; Yuan S; Pan C; Dong W; Zhang J; Zhang L; Lin J; Yin Y; Wu J
+Author NameID
+ Lin, Jilei; ORCID: https://orcid.org/0000-0003-1920-9317
+Authors Full Name
+ Ying, Xiaolan; Lin, Jie; Yuan, Shuhua; Pan, Chunhong; Dong, Wenfang; Zhang, Jing; Zhang, Lei; Lin, Jilei; Yin, Yong; Wu, Jinhong.
+Institution
+ Ying, Xiaolan. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Lin, Jie. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Yuan, Shuhua. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Pan, Chunhong. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Dong, Wenfang. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Zhang, Jing. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Zhang, Lei. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Lin, Jilei. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Yin, Yong. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+ Wu, Jinhong. Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.
+MeSH Subject Headings
+ Adiponectin
+ Adiposity
+ Adolescent
+ *Asthma
+ Biomarkers
+ Child
+ Child, Preschool
+ China
+ Forced Expiratory Volume
+ Humans
+ *Hypersensitivity, Immediate
+ Inflammation/co [Complications]
+ Interleukin-16
+ Leptin
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+Keyword Heading
+ adolescents
+ asthma
+ atopy
+ body mass index (BMI)
+ children
+ inflammation
+ obesity
+ pulmonary function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ (1) Background: The relationship between obesity and asthma is still uncertain. This study aimed to investigate the effect of overweight/obesity on the pulmonary function of patients with new-onset pediatric asthma and explore the possible causative factors related to concomitant obesity and asthma. (2) Methods: Patients aged 5 to 17 years old with newly diagnosed mild to moderate asthma were recruited from June 2018 to May 2019, from a respiratory clinic in Shanghai, China. Participants were categorized into three groups: normal weight, overweight, and obese asthma. A family history of atopy and patients' personal allergic diseases were recorded. Pulmonary function, fractional exhaled nitric oxide (FeNO), eosinophils, serum-specific immunoglobulins E (sIgE), serum total IgE (tIgE), and serum inflammatory biomarkers (adiponectin, leptin, Type 1 helper T, and Type 2 helper T cytokines) were tested in all participants. (3) Results: A total of 407 asthma patients (197 normal weight, 92 overweight, and 118 obese) were enrolled. There was a reduction in forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC), FEV1/FVC%, and FEF25-75% in the overweight/obese groups. No difference was found between the study groups in the main allergy characteristics. Leptin levels were higher while adiponectin was lower in asthmatics with obesity. Higher levels of IL-16 were found in overweight/obese asthmatic individuals than in normal-weight individuals. (4) Conclusions: Obesity may have an effect on impaired pulmonary function. While atopic inflammation plays an important role in the onset of asthma, nonatopic inflammation (including leptin and adiponectin) increases the severity of asthma in overweight/obese patients. The significance of different levels of IL-16 between groups needs to be further studied.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Interleukin-16). 0 (Leptin).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14142968
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ying&issn=2072-6643&title=Nutrients&atitle=Comparison+of+Pulmonary+Function+and+Inflammation+in+Children%2FAdolescents+with+New-Onset+Asthma+with+Different+Adiposity+Statuses.&volume=14&issue=14&spage=&epage=&date=2022&doi=10.3390%2Fnu14142968&pmid=35889925&sid=OVID:medline
+
+<447>
+Unique Identifier
+ 35889892
+Title
+ Biomarker of Stress, Metabolic Syndrome and Human Health.
+Source
+ Nutrients. 14(14), 2022 Jul 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bouillon-Minois JB; Dutheil F
+Author NameID
+ Bouillon-Minois, Jean-Baptiste; ORCID: https://orcid.org/0000-0002-6556-4187
+ Dutheil, Frederic; ORCID: https://orcid.org/0000-0002-1468-6029
+Authors Full Name
+ Bouillon-Minois, Jean-Baptiste; Dutheil, Frederic.
+Institution
+ Bouillon-Minois, Jean-Baptiste. Universite Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, F-63000 Clermont-Ferrand, France.
+ Bouillon-Minois, Jean-Baptiste. CHU Clermont-Ferrand, Emergency Medicine, F-63000 Clermont-Ferrand, France.
+ Dutheil, Frederic. Universite Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, F-63000 Clermont-Ferrand, France.
+ Dutheil, Frederic. CHU Clermont-Ferrand, Occupational and Environmental Medicine, WittyFit, F-63000 Clermont-Ferrand, France.
+MeSH Subject Headings
+ Biomarkers
+ Humans
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome
+ Obesity/ep [Epidemiology]
+Abstract
+ Metabolic syndrome is a significant public health concern linked to the obesity pandemic [...].
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14142935
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bouillon-Minois&issn=2072-6643&title=Nutrients&atitle=Biomarker+of+Stress%2C+Metabolic+Syndrome+and+Human+Health.&volume=14&issue=14&spage=&epage=&date=2022&doi=10.3390%2Fnu14142935&pmid=35889892&sid=OVID:medline
+
+<448>
+Unique Identifier
+ 35889883
+Title
+ Epicardial Adipose Tissue: A Novel Potential Imaging Marker of Comorbidities Caused by Chronic Inflammation. [Review]
+Source
+ Nutrients. 14(14), 2022 Jul 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tarsitano MG; Pandozzi C; Muscogiuri G; Sironi S; Pujia A; Lenzi A; Giannetta E
+Authors Full Name
+ Tarsitano, Maria Grazia; Pandozzi, Carla; Muscogiuri, Giuseppe; Sironi, Sandro; Pujia, Arturo; Lenzi, Andrea; Giannetta, Elisa.
+Institution
+ Tarsitano, Maria Grazia. Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, Italy.
+ Pandozzi, Carla. Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy.
+ Muscogiuri, Giuseppe. School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
+ Muscogiuri, Giuseppe. IRCCS, Istituto Auxologico Italiano, 20126 Milan, Italy.
+ Sironi, Sandro. School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
+ Sironi, Sandro. Department of Radiology, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
+ Pujia, Arturo. Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, Italy.
+ Lenzi, Andrea. Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy.
+ Giannetta, Elisa. Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy.
+MeSH Subject Headings
+ Adipose Tissue/dg [Diagnostic Imaging]
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue
+ Adiposity
+ Biomarkers/me [Metabolism]
+ Coronary Artery Disease/me [Metabolism]
+ *Coronary Artery Disease
+ Humans
+ Inflammation/me [Metabolism]
+ Intra-Abdominal Fat/dg [Diagnostic Imaging]
+ Intra-Abdominal Fat/me [Metabolism]
+ Obesity/me [Metabolism]
+ Pericardium/dg [Diagnostic Imaging]
+ Pericardium/me [Metabolism]
+ Risk Factors
+Keyword Heading
+ CMR
+ cardiometabolic risk
+ cardiovascular diseases
+ coronary CT
+ diabetes
+ echocardiography
+ epicardial adipose tissue
+ inflammation
+ metabolic syndrome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The observation of correlations between obesity and chronic metabolic and cardiovascular diseases has led to the emergence of strong interests in "adipocyte biology", in particular in relation to a specific visceral adipose tissue that is the epicardial adipose tissue (EAT) and its pro-inflammatory role. In recent years, different imaging techniques frequently used in daily clinical practice have tried to obtain an EAT quantification. We provide a useful update on comorbidities related to chronic inflammation typical of cardiac adiposity, analyzing how the EAT assessment could impact and provide data on the patient prognosis. We assessed for eligibility 50 papers, with a total of 10,458 patients focusing the review on the evaluation of EAT in two main contexts: cardiovascular and metabolic diseases. Given its peculiar properties and rapid responsiveness, EAT could act as a marker to investigate the basal risk factor and follow-up conditions. In the future, EAT could represent a therapeutic target for new medications. The assessment of EAT should become part of clinical practice to help clinicians to identify patients at greater risk of developing cardiovascular and/or metabolic diseases and to provide information on their clinical and therapeutic outcomes.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14142926
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tarsitano&issn=2072-6643&title=Nutrients&atitle=Epicardial+Adipose+Tissue%3A+A+Novel+Potential+Imaging+Marker+of+Comorbidities+Caused+by+Chronic+Inflammation.&volume=14&issue=14&spage=&epage=&date=2022&doi=10.3390%2Fnu14142926&pmid=35889883&sid=OVID:medline
+
+<449>
+Unique Identifier
+ 35883542
+Title
+ Metabolomic Analysis of Human Astrocytes in Lipotoxic Condition: Potential Biomarker Identification by Machine Learning Modeling.
+Source
+ Biomolecules. 12(7), 2022 07 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Castellanos DB; Martin-Jimenez CA; Pinzon A; Barreto GE; Padilla-Gonzalez GF; Aristizabal A; Zuluaga M; Gonzalez Santos J
+Author NameID
+ Pinzon, Andres; ORCID: https://orcid.org/0000-0002-4133-810X
+ Padilla-Gonzalez, Guillermo Federico; ORCID: https://orcid.org/0000-0002-8300-6891
+ Aristizabal, Andres; ORCID: https://orcid.org/0000-0003-3004-4867
+ Zuluaga, Martha; ORCID: https://orcid.org/0000-0003-1720-8476
+ Gonzalez Santos, Janneth; ORCID: https://orcid.org/0000-0003-2009-3374
+Authors Full Name
+ Castellanos, Daniel Baez; Martin-Jimenez, Cynthia A; Pinzon, Andres; Barreto, George E; Padilla-Gonzalez, Guillermo Federico; Aristizabal, Andres; Zuluaga, Martha; Gonzalez Santos, Janneth.
+Institution
+ Castellanos, Daniel Baez. Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota 110311, Colombia.
+ Martin-Jimenez, Cynthia A. Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Atlanta, GA 30329-4208, USA.
+ Pinzon, Andres. Laboratorio de Bioinformatica y Biologia de Sistemas, Universidad Nacional de Colombia, Bogota 111321, Colombia.
+ Barreto, George E. Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland.
+ Padilla-Gonzalez, Guillermo Federico. Royal Botanic Gardens, Kew, London TW9 3AE, UK.
+ Aristizabal, Andres. Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota 110311, Colombia.
+ Zuluaga, Martha. Escuela de Ciencias Basicas Tecnologias e Ingenierias, Universidad Nacional Abierta y a Distancia, Dosquebradas 661001, Colombia.
+ Gonzalez Santos, Janneth. Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota 110311, Colombia.
+MeSH Subject Headings
+ Astrocytes/me [Metabolism]
+ *Astrocytes
+ Biomarkers/me [Metabolism]
+ Glutamic Acid/me [Metabolism]
+ *Glutamic Acid
+ Humans
+ Machine Learning
+ Obesity/me [Metabolism]
+Keyword Heading
+ astrocytes
+ lipotoxicity
+ metabolomics
+ neurodegenerative diseases
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The association between neurodegenerative diseases (NDs) and obesity has been well studied in recent years. Obesity is a syndrome of multifactorial etiology characterized by an excessive accumulation and release of fatty acids (FA) in adipose and non-adipose tissue. An excess of FA generates a metabolic condition known as lipotoxicity, which triggers pathological cellular and molecular responses, causing dysregulation of homeostasis and a decrease in cell viability. This condition is a hallmark of NDs, and astrocytes are particularly sensitive to it, given their crucial role in energy production and oxidative stress management in the brain. However, analyzing cellular mechanisms associated with these conditions represents a challenge. In this regard, metabolomics is an approach that allows biochemical analysis from the comprehensive perspective of cell physiology. This technique allows cellular metabolic profiles to be determined in different biological contexts, such as those of NDs and specific metabolic insults, including lipotoxicity. Since data provided by metabolomics can be complex and difficult to interpret, alternative data analysis techniques such as machine learning (ML) have grown exponentially in areas related to omics data. Here, we developed an ML model yielding a 93% area under the receiving operating characteristic (ROC) curve, with sensibility and specificity values of 80% and 93%, respectively. This study aimed to analyze the metabolomic profiles of human astrocytes under lipotoxic conditions to provide powerful insights, such as potential biomarkers for scenarios of lipotoxicity induced by palmitic acid (PA). In this work, we propose that dysregulation in seleno-amino acid metabolism, urea cycle, and glutamate metabolism pathways are major triggers in astrocyte lipotoxic scenarios, while increased metabolites such as alanine, adenosine, and glutamate are suggested as potential biomarkers, which, to our knowledge, have not been identified in human astrocytes and are proposed as candidates for further research and validation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3KX376GY7L (Glutamic Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fbiom12070986
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Castellanos&issn=2218-273X&title=Biomolecules&atitle=Metabolomic+Analysis+of+Human+Astrocytes+in+Lipotoxic+Condition%3A+Potential+Biomarker+Identification+by+Machine+Learning+Modeling.&volume=12&issue=7&spage=&epage=&date=2022&doi=10.3390%2Fbiom12070986&pmid=35883542&sid=OVID:medline
+
+<450>
+Unique Identifier
+ 35879706
+Title
+ The relationship between dietary phytochemical index and resting metabolic rate mediated by inflammatory factors in overweight and obese women: a cross-sectional study.
+Source
+ BMC Women's Health. 22(1):313, 2022 07 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mirzababaei A; Taheri A; Rasaei N; Mehranfar S; Jamili S; Clark CCT; Mirzaei K
+Authors Full Name
+ Mirzababaei, Atieh; Taheri, Akram; Rasaei, Niloufar; Mehranfar, Sanaz; Jamili, Shahin; Clark, Cain C T; Mirzaei, Khadijeh.
+Institution
+ Mirzababaei, Atieh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Taheri, Akram. Department of Nutrition, Faculty of Medicine, Sciences and Research Branch, Islamic Azad, University, Tehran, Iran.
+ Rasaei, Niloufar. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Mehranfar, Sanaz. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Jamili, Shahin. Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Clark, Cain C T. Centre for Intelligent Healthcare, Coventry University, Coventry, U.K.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. mirzaei_kh@tums.ac.ir.
+ Mirzaei, Khadijeh. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. mirzaei_kh@tums.ac.ir.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Basal Metabolism
+ Biomarkers
+ Cross-Sectional Studies
+ Female
+ Humans
+ Middle Aged
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+ *Overweight
+ Phytochemicals
+ Plasminogen Activator Inhibitor 1
+ Transforming Growth Factor beta
+ Young Adult
+Keyword Heading
+ Dietary phytochemical index
+ Inflammatory marker
+ Obesity and overweight
+ Resting metabolic rate
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Unhealthy dietary patterns are the most important modifiable risk factors for obesity and overweight. This study aimed to examine the relationship between Dietary Phytochemical Index (DPI) and resting metabolic rate (RMR), mediated by inflammatory factors, in overweight and obese women.
+
+ METHODS: A total of 404 women, aged 18-48 years, were included in the cross-sectional study. DPI was calculated using the 147-item food frequency questionnaire (FFQ). Anthropometric measurements, RMR, and blood biomarkers were assessed using standard protocols.
+
+ RESULTS: There was marginally significant association between adherence to DPI and RMR status in the crude model (OR = 1.41, 95% CI 0.94-2.11, P = 0.09). After adjusting for potential confounders, a significant association was seen between the DPI and increase RMR.per.kg (OR = 2.77, 95% CI 0.98-7.82, P = 0.05). Our results indicated that plasminogen activator inhibitor-1 (PAI-1), transforming growth factor (TGF-beta), and monocyte chemoattractant protein-1 (MCP-1) had a mediatory effect on the association between RMR and DPI (P > 0.05). Indeed, it was shown that, PAI-1, TGF-beta, and MCP-1 destroyed the significance of this association and could be considered as mediating markers. However, no mediating effect was observed for high-sensitivity C reactive protein (hs-CRP).
+
+ CONCLUSIONS: Adherence to DPI can improve the RMR by reducing levels of inflammatory markers, and may be considered as a treatment for obesity. However, more long-term studies are recommended. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phytochemicals). 0 (Plasminogen Activator Inhibitor 1). 0 (Transforming Growth Factor beta).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12905-022-01894-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mirzababaei&issn=1472-6874&title=BMC+Women%27s+Health&atitle=The+relationship+between+dietary+phytochemical+index+and+resting+metabolic+rate+mediated+by+inflammatory+factors+in+overweight+and+obese+women%3A+a+cross-sectional+study.&volume=22&issue=1&spage=313&epage=&date=2022&doi=10.1186%2Fs12905-022-01894-9&pmid=35879706&sid=OVID:medline
+
+<451>
+Unique Identifier
+ 35879202
+Title
+ Neck circumference is a better correlate of insulin resistance markers than other standard anthropometric indices in patients presenting severe obesity.
+Source
+ Obesity Research & Clinical Practice. 16(4):307-313, 2022 Jul-Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Scovronec A; Provencher A; Iceta S; Pelletier M; Leblanc V; Nadeau M; Simard S; Biertho L; Richard D; Tchernof A; Michaud A
+Authors Full Name
+ Scovronec, Anais; Provencher, Amelie; Iceta, Sylvain; Pelletier, Melissa; Leblanc, Vicky; Nadeau, Melanie; Simard, Serge; Biertho, Laurent; Richard, Denis; Tchernof, Andre; Michaud, Andreanne.
+Institution
+ Scovronec, Anais. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada; Ecole de Nutrition, Universite Laval, Quebec, Canada.
+ Provencher, Amelie. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada; Ecole de Nutrition, Universite Laval, Quebec, Canada.
+ Iceta, Sylvain. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada.
+ Pelletier, Melissa. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada.
+ Leblanc, Vicky. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada; Ecole de Nutrition, Universite Laval, Quebec, Canada.
+ Nadeau, Melanie. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada.
+ Simard, Serge. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada.
+ Biertho, Laurent. Departement de chirurgie, Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada.
+ Richard, Denis. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada.
+ Tchernof, Andre. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada; Ecole de Nutrition, Universite Laval, Quebec, Canada.
+ Michaud, Andreanne. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec, Canada; Ecole de Nutrition, Universite Laval, Quebec, Canada. Electronic address: andreanne.michaud@criucpq.ulaval.ca.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Mass Index
+ *Diabetes Mellitus, Type 2
+ Female
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Neck
+ Obesity
+ *Obesity, Morbid
+ Risk Factors
+ Waist Circumference
+Keyword Heading
+ Anthropometric indices
+ Cardiometabolic risk factors
+ Neck circumference
+ Severe obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Previous studies have demonstrated stronger associations between metabolic alterations and neck circumference (NC) than with body mass index (BMI) or waist circumference (WC). However, most of these studies were performed in individuals presenting overweight or mild obesity.
+
+ OBJECTIVE: To determine which adiposity index among BMI, WC, NC and fat mass (FM) can best predict metabolic alterations in men and women presenting severe obesity.
+
+ METHODS: Anthropometric and plasma biochemical parameters were measured in 81 participants presenting severe obesity (19 men, 62 women; age: 44.5 +/- 8.9 years; BMI: 43.5 +/- 4.1 kg/m2). Multiple linear regressions were used to determine the best predictors of metabolic alterations among each adiposity index.
+
+ RESULTS: NC was positively correlated with fasting insulin concentrations, C-peptide concentrations and HOMA-IR values and negatively correlated with HDL-C concentrations. NC was the best predictor of glucose homeostasis indices and HDL-C concentrations in models also including sex, BMI, WC, and FM. The ROC curve analysis indicated that a NC >= 37.8 cm best predicted type 2 diabetes.
+
+ CONCLUSIONS: NC seems a better predictor of insulin resistance and lower HDL-C concentrations in patients presenting severe obesity compared to other standard anthropometric indices, and particularly in women. The small sample size in men prevent us to draw clear conclusions. NC could be useful in targeting patients with metabolic alterations who could benefit from medical or surgical treatment of obesity. Copyright © 2022 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.orcp.2022.07.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Scovronec&issn=1871-403X&title=Obesity+Research+%26+Clinical+Practice&atitle=Neck+circumference+is+a+better+correlate+of+insulin+resistance+markers+than+other+standard+anthropometric+indices+in+patients+presenting+severe+obesity.&volume=16&issue=4&spage=307&epage=313&date=2022&doi=10.1016%2Fj.orcp.2022.07.005&pmid=35879202&sid=OVID:medline
+
+<452>
+Unique Identifier
+ 35862175
+Title
+ Incidence of Preclinical Heart Failure in a Community Population.
+Source
+ Journal of the American Heart Association. 11(15):e025519, 2022 08 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Young KA; Scott CG; Rodeheffer RJ; Chen HH
+Author NameID
+ Young, Kathleen A; ORCID: https://orcid.org/0000-0002-7071-192X
+ Scott, Christopher G; ORCID: https://orcid.org/0000-0003-1340-0647
+ Chen, Horng H; ORCID: https://orcid.org/0000-0002-2315-0330
+Authors Full Name
+ Young, Kathleen A; Scott, Christopher G; Rodeheffer, Richard J; Chen, Horng H.
+Institution
+ Young, Kathleen A. Department of Cardiovascular Diseases Mayo Clinic Rochester MN United States.
+ Scott, Christopher G. Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN United States.
+ Rodeheffer, Richard J. Department of Cardiovascular Diseases Mayo Clinic Rochester MN United States.
+ Chen, Horng H. Department of Cardiovascular Diseases Mayo Clinic Rochester MN United States.
+MeSH Subject Headings
+ Biomarkers
+ Echocardiography/mt [Methods]
+ Heart Failure/ep [Epidemiology]
+ *Heart Failure
+ Humans
+ *Hypertension
+ Incidence
+ Natriuretic Peptide, Brain
+ Obesity/ep [Epidemiology]
+ Peptide Fragments
+Keyword Heading
+ incidence
+ natural history
+ preclinical heart failure
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background A high prevalence of preclinical heart failure (HF) (Stages A and B) has previously been shown. The aim of this study was to explore factors associated with the incidence of preclinical HF in a community population. Methods and Results Retrospective review of 393 healthy community individuals aged >=45 years from the Olmsted County Heart Function Study that returned for 2 visits, 4 years apart. At visit 2, individuals that remained normal were compared with those that developed preclinical HF. By the second visit, 191 (49%) developed preclinical HF (12.1 cases per 100 person-years of follow-up); 65 (34%) Stage A and 126 (66%) Stage B. Those that developed preclinical HF (n=191) were older (P=0.004), had a higher body mass index (P<0.001), and increased left ventricular mass index (P=0.006). When evaluated separately, increased body mass index was seen with development of Stage A (P<0.001) or Stage B (P=0.009). Echocardiographic markers of diastolic function were statistically different in those that developed Stage A [higher E/e' (P<0.001), lower e' (P<0.001)] and Stage B [higher left atrial volume index (P<0.001), higher E/e' (P<0.001), lower e' (P<0.001)]. NT-proBNP (N-terminal pro-B-type natriuretic peptide) was higher at visit 2 in those that developed Stage A or B (P<0.001 for both). Hypertension (57%), obesity (34%), and hyperlipidemia (25%) were common in the development of Stage A. Of patients who developed Stage B, 71% (n=84) had moderate or severe diastolic dysfunction. Conclusions There is a high incidence of preclinical HF in a community population. Development of Stage A was driven by hypertension and obesity, while preclinical diastolic dysfunction was seen commonly in those that developed Stage B.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1161%2fJAHA.122.025519
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Young&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Incidence+of+Preclinical+Heart+Failure+in+a+Community+Population.&volume=11&issue=15&spage=e025519&epage=&date=2022&doi=10.1161%2FJAHA.122.025519&pmid=35862175&sid=OVID:medline
+
+<453>
+Unique Identifier
+ 35858946
+Title
+ Normalized sensitivity of multi-dimensional body composition biomarkers for risk change prediction.
+Source
+ Scientific Reports. 12(1):12375, 2022 07 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Criminisi A; Sorek N; Heymsfield SB
+Author NameID
+ Criminisi, A; ORCID: https://orcid.org/0000-0002-3668-7014
+Authors Full Name
+ Criminisi, A; Sorek, N; Heymsfield, S B.
+Institution
+ Criminisi, A. Amazon, Inc., Cambridge, UK. antcrim@live.co.uk.
+ Criminisi, A. Amazon, Inc., 2121 7th Avenue, Seattle, WA, 98121, USA. antcrim@live.co.uk.
+ Sorek, N. Amazon, Inc., Tel Aviv, Israel.
+ Heymsfield, S B. Amazon, Inc., 2121 7th Avenue, Seattle, WA, 98121, USA.
+ Heymsfield, S B. Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, USA.
+MeSH Subject Headings
+ *Adiposity
+ Biomarkers
+ *Body Composition
+ Body Mass Index
+ Humans
+ Nutrition Surveys
+ Obesity
+Abstract
+ The limitations of BMI as a measure of adiposity and health risks have prompted the introduction of many alternative biomarkers. However, ranking diverse biomarkers from best to worse remains challenging. This study aimed to address this issue by introducing three new approaches: (1) a calculus-derived, normalized sensitivity score (NORSE) is used to compare the predictive power of diverse adiposity biomarkers; (2) multiple biomarkers are combined into multi-dimensional models, for increased sensitivity and risk discrimination; and (3) new visualizations are introduced that convey complex statistical trends in a compact and intuitive manner. Our approach was evaluated on 23 popular biomarkers and 6 common medical conditions using a large database (National Health and Nutrition Survey, NHANES, N ~ 100,000). Our analysis established novel findings: (1) regional composition biomarkers were more predictive of risk than global ones; (2) fat-derived biomarkers had stronger predictive power than weight-related ones; (3) waist and hip are always elements of the strongest risk predictors; (4) our new, multi-dimensional biomarker models yield higher sensitivity, personalization, and separation of the negative effects of fat from the positive effects of lean mass. Our approach provides a new way to evaluate adiposity biomarkers, brings forth new important clinical insights and sets a path for future biomarker research. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41598-022-16142-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Criminisi&issn=2045-2322&title=Scientific+Reports&atitle=Normalized+sensitivity+of+multi-dimensional+body+composition+biomarkers+for+risk+change+prediction.&volume=12&issue=1&spage=12375&epage=&date=2022&doi=10.1038%2Fs41598-022-16142-1&pmid=35858946&sid=OVID:medline
+
+<454>
+Unique Identifier
+ 35854006
+Title
+ Long non-coding RNAs: a valuable biomarker for metabolic syndrome. [Review]
+Source
+ Molecular Genetics & Genomics: MGG. 297(5):1169-1183, 2022 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rashidmayvan M; Sahebi R; Ghayour-Mobarhan M
+Author NameID
+ Rashidmayvan, Mohammad; ORCID: http://orcid.org/0000-0003-3541-5604
+Authors Full Name
+ Rashidmayvan, Mohammad; Sahebi, Reza; Ghayour-Mobarhan, Majid.
+Institution
+ Rashidmayvan, Mohammad. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Sahebi, Reza. Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ghayour-Mobarhan, Majid. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Ghayourm@mums.ac.ir.
+MeSH Subject Headings
+ Biomarkers
+ Homeostasis
+ Humans
+ *Metabolic Syndrome
+ Obesity
+ *RNA, Long Noncoding
+Keyword Heading
+ Hypertension
+ Insulin resistance
+ Long noncoding RNA
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Long non-coding RNAs (lncRNAs) have become important regulators of gene expression because they affect a wide range of biological processes, such as cell growth, death, differentiation, and aging. More and more evidence suggests that lncRNAs play a role in maintaining metabolic homeostasis. When certain lncRNAs are out of balance, metabolic disorders like diabetes, obesity, and heart disease get worse. In this review, we talk about what we know about how lncRNAs control metabolism, with a focus on diseases caused by long-term inflammation and the characteristics of the metabolic syndrome. We looked at lncRNAs and their molecular targets in the pathogenesis of signaling pathways. We also talked about how lncRNAs are becoming more and more interesting as diagnostic and therapeutic targets for improving metabolic homeostasis. Copyright © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Long Noncoding).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs00438-022-01922-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rashidmayvan&issn=1617-4623&title=Molecular+Genetics+%26+Genomics%3A+MGG&atitle=Long+non-coding+RNAs%3A+a+valuable+biomarker+for+metabolic+syndrome.&volume=297&issue=5&spage=1169&epage=1183&date=2022&doi=10.1007%2Fs00438-022-01922-1&pmid=35854006&sid=OVID:medline
+
+<455>
+Unique Identifier
+ 35852450
+Title
+ Relationship between obesity-related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic.
+Source
+ Andrologia. 54(10):e14524, 2022 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Esmaeili V; Zendehdel M; Shahverdi A; Alizadeh A
+Author NameID
+ Esmaeili, Vahid; ORCID: https://orcid.org/0000-0002-8179-9947
+ Zendehdel, Morteza; ORCID: https://orcid.org/0000-0001-8252-9423
+ Shahverdi, Abdolhossein; ORCID: https://orcid.org/0000-0002-9615-4586
+ Alizadeh, AliReza; ORCID: https://orcid.org/0000-0001-7273-9793
+Authors Full Name
+ Esmaeili, Vahid; Zendehdel, Morteza; Shahverdi, Abdolhossein; Alizadeh, AliReza.
+Institution
+ Esmaeili, Vahid. Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
+ Zendehdel, Morteza. Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
+ Shahverdi, Abdolhossein. Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine ACECR, Tehran, Iran.
+ Alizadeh, AliReza. Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine ACECR, Tehran, Iran.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Cross-Sectional Studies
+ Estradiol
+ *Fertility Clinics
+ Humans
+ Male
+ Obesity/co [Complications]
+ Risk Factors
+ *Semen
+ Spermatozoa/ph [Physiology]
+ Testosterone
+ Waist Circumference
+Keyword Heading
+ BMI
+ obesity-related markers
+ semen quality
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity causes many health problems as well as has negative effects on fertility. However, little is known about the association between obesity-related markers (hip circumference (HC), waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), body fat mass (BFM), skeletal muscle (SM), resting metabolism (RM), visceral fat (VF), and visceral adiposity index (VAI)) and sperm parameters. This cross-sectional study was conducted on 98 men in three groups: normal-weight (Nw; body mass index: BMI < 25 kg/m2 ), overweight (Ow; BMI: 25-29 kg/m2 ), and obese (Ob; BMI: 30-35 kg/m2 ) to investigate this issue. The mean WC, HC, WHtR, BFM, SM, RM, and VF were remarkably higher (p < 0.001) for subjects in the Ob group than in Ow and Nw. In Nw, positive correlations were observed between BFM (r = 0.402) and VAI (r = 0.353) and sperm progressive motility (p < 0.05). In Ob males, there was a positive correlation (r = 0.430) between sperm progressive motility and height and a negative relation (r = -0.447) between sperm progressive motility and WHtR. We found the association between serum testosterone (T) levels, T/estradiol ratios, and semen parameters being dependent on obesity-related markers which confirms the negative effects of obesity on male hormones. In conclusion, WHtR is a valuable parameter in infertility clinics that warrants further studies. Copyright © 2022 Wiley-VCH GmbH.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3XMK78S47O (Testosterone). 4TI98Z838E (Estradiol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2fand.14524
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Esmaeili&issn=0303-4569&title=Andrologia&atitle=Relationship+between+obesity-related+markers%2C+biochemical+metabolic+parameters%2C+hormonal+profiles+and+sperm+parameters+among+men+attending+an+infertility+clinic.&volume=54&issue=10&spage=e14524&epage=&date=2022&doi=10.1111%2Fand.14524&pmid=35852450&sid=OVID:medline
+
+<456>
+Unique Identifier
+ 35851710
+Title
+ Clinical effect of obesity on N-terminal pro-B-type natriuretic peptide cut-off concentrations for the diagnosis of acute heart failure.
+Source
+ European Journal of Heart Failure. 24(9):1545-1554, 2022 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kozhuharov N; Martin J; Wussler D; Lopez-Ayala P; Belkin M; Strebel I; Flores D; Diebold M; Shrestha S; Nowak A; Gualandro DM; Michou E; Zimmermann T; Rentsch K; von Eckardstein A; Keller DI; Breidthardt T; Mueller C
+Corporate Author
+ BASEL V Investigators
+Authors Full Name
+ Kozhuharov, Nikola; Martin, Jasmin; Wussler, Desiree; Lopez-Ayala, Pedro; Belkin, Maria; Strebel, Ivo; Flores, Dayana; Diebold, Matthias; Shrestha, Samyut; Nowak, Albina; Gualandro, Danielle M; Michou, Eleni; Zimmermann, Tobias; Rentsch, Katharina; von Eckardstein, Arnold; Keller, Dagmar I; Breidthardt, Tobias; Mueller, Christian.
+Institution
+ Kozhuharov, Nikola. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Kozhuharov, Nikola. Department of Cardiology, Liverpool Heart and Chest Hospital, Liverpool, UK.
+ Martin, Jasmin. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Martin, Jasmin. Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Wussler, Desiree. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Wussler, Desiree. Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Lopez-Ayala, Pedro. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Lopez-Ayala, Pedro. Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Belkin, Maria. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Belkin, Maria. Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Strebel, Ivo. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Flores, Dayana. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Diebold, Matthias. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Diebold, Matthias. Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Shrestha, Samyut. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Shrestha, Samyut. Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Nowak, Albina. Department of Endocrinology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
+ Gualandro, Danielle M. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Michou, Eleni. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Zimmermann, Tobias. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Zimmermann, Tobias. Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Zimmermann, Tobias. Department of Intensive Care Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Rentsch, Katharina. Department of Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
+ von Eckardstein, Arnold. Department of Laboratory Medicine, University Hospital Zurich, Zurich, Switzerland.
+ Keller, Dagmar I. Institute for Emergency Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
+ Breidthardt, Tobias. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+ Breidthardt, Tobias. Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
+ Mueller, Christian. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Acute Disease
+ Aged
+ Biomarkers
+ Heart Failure/di [Diagnosis]
+ *Heart Failure
+ Humans
+ Middle Aged
+ *Natriuretic Peptide, Brain
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Peptide Fragments
+ Prospective Studies
+Keyword Heading
+ Acute heart failure
+ Cut-offs
+ Diagnosis
+ Natriuretic peptides
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Obese patients have lower natriuretic peptide concentrations. We hypothesized that adjusting the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for obesity could further increase its clinical utility in the early diagnosis of acute heart failure (AHF).
+
+ METHODS AND RESULTS: This hypothesis was tested in a prospective diagnostic study enrolling unselected patients presenting to the emergency department with acute dyspnoea. Two independent cardiologists/internists centrally adjudicated the final diagnosis using all individual patient information including cardiac imaging. NT-proBNP plasma concentrations were applied: first, using currently recommended cut-offs; second, using cut-offs lowered by 33% with body mass index (BMI) of 30-34.9 kg/m2 and by 50% with BMI >= 35 kg/m2 . Among 2038 patients, 509 (25%) were obese, of which 271 (53%) had AHF. The diagnostic accuracy of NT-proBNP as quantified by the area under the receiver-operating characteristic curve was lower in obese versus non-obese patients (0.890 vs. 0.938). For rapid AHF rule-out in obese patients, the currently recommended cut-off of 300 pg/ml achieved a sensitivity of 96.7% (95% confidence interval [CI] 93.8-98.2%), ruling out 29% of patients and missing 9 AHF patients. For rapid AHF rule-in, the age-dependent cut-off concentrations (age <50 years: 450 pg/ml; age 50-75 years: 900 pg/ml; age >75 years: 1800 pg/ml) achieved a specificity of 84.9% (95% CI 79.8-88.9%). Proportionally lowering the currently recommended cut-offs by BMI increased sensitivity to 98.2% (95% CI 95.8-99.2%), missing 5 AHF patients; reduced the proportion of AHF patients remaining in the 'gray zone' (48% vs. 26%; p = 0.002), achieving a specificity of 76.5% (95% CI 70.7-81.4%).
+
+ CONCLUSIONS: Adjusting NT-proBNP concentrations for obesity seems to further increase its clinical utility in the early diagnosis of AHF. Copyright © 2022 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1002%2fejhf.2618
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kozhuharov&issn=1388-9842&title=European+Journal+of+Heart+Failure&atitle=Clinical+effect+of+obesity+on+N-terminal+pro-B-type+natriuretic+peptide+cut-off+concentrations+for+the+diagnosis+of+acute+heart+failure.&volume=24&issue=9&spage=1545&epage=1554&date=2022&doi=10.1002%2Fejhf.2618&pmid=35851710&sid=OVID:medline
+
+<457>
+Unique Identifier
+ 35840771
+Title
+ Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity.
+Source
+ International Journal of Obesity. 46(10):1801-1807, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van Oers JAH; Pouwels S; Ramnarain D; Kluiters Y; Bons JAP; de Lange DW; de Grooth HJ; Girbes ARJ
+Author NameID
+ van Oers, Jos A H; ORCID: http://orcid.org/0000-0001-8666-9810
+ Pouwels, Sjaak; ORCID: http://orcid.org/0000-0002-6390-7692
+Authors Full Name
+ van Oers, Jos A H; Pouwels, Sjaak; Ramnarain, Dharmanand; Kluiters, Yvette; Bons, Judith A P; de Lange, Dylan W; de Grooth, Harm-Jan; Girbes, Armand R J.
+Institution
+ van Oers, Jos A H. Department of Intensive Care Medicine, Elisabeth Tweesteden Ziekenhuis, Tilburg, The Netherlands. jah.vanoers@etz.nl.
+ Pouwels, Sjaak. Department of Intensive Care Medicine, Elisabeth Tweesteden Ziekenhuis, Tilburg, The Netherlands.
+ Ramnarain, Dharmanand. Department of Intensive Care Medicine, Elisabeth Tweesteden Ziekenhuis, Tilburg, The Netherlands.
+ Kluiters, Yvette. Department of Clinical Chemistry, Elisabeth Tweesteden Ziekenhuis, Tilburg, The Netherlands.
+ Bons, Judith A P. Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, The Netherlands.
+ de Lange, Dylan W. Department of Intensive Care Medicine, University Medical Centre Utrecht, University Utrecht, Utrecht, The Netherlands.
+ de Grooth, Harm-Jan. Department of Intensive Care Medicine, Amsterdam UMC, Medical Centres, VU University Medical Centre, Amsterdam, The Netherlands.
+ Girbes, Armand R J. Department of Intensive Care Medicine, Amsterdam UMC, Medical Centres, VU University Medical Centre, Amsterdam, The Netherlands.
+MeSH Subject Headings
+ Adrenomedullin/bl [Blood]
+ *Adrenomedullin
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ COVID-19/bl [Blood]
+ COVID-19/co [Complications]
+ COVID-19/di [Diagnosis]
+ *COVID-19
+ Critical Care
+ Critical Illness
+ Disease Progression
+ Endothelin-1/bl [Blood]
+ *Endothelin-1
+ Humans
+ Obesity/co [Complications]
+ *Obesity
+ Patient Admission
+ Peptide Fragments/bl [Blood]
+ *Peptide Fragments
+ Procalcitonin/bl [Blood]
+ Prognosis
+ Protein Precursors/bl [Blood]
+ *Protein Precursors
+ Retrospective Studies
+ *SARS-CoV-2
+Abstract
+ BACKGROUND/OBJECTIVES: Patients affected by obesity and Coronavirus disease 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appear to have a higher risk for intensive care (ICU) admission. A state of low-grade chronic inflammation in obesity has been suggested as one of the underlying mechanisms. We investigated whether obesity is associated with differences in new inflammatory biomarkers mid-regional proadrenomedullin (MR-proADM), C-terminal proendothelin-1 (CT-proET-1), and clinical outcomes in critically ill patients with SARS-CoV-2 pneumonia.
+
+ SUBJECTS/METHODS: A total of 105 critically ill patients with SARS-CoV-2 pneumonia were divided in patients with obesity (body mass index (BMI) >= 30 kg/m2, n = 42) and patients without obesity (BMI < 30 kg/m2, n = 63) and studied in a retrospective observational cohort study. MR-proADM, CT-proET-1 concentrations, and conventional markers of white blood count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were collected during the first 7 days.
+
+ RESULTS: BMI was 33.5 (32-36.1) and 26.2 (24.7-27.8) kg/m2 in the group with and without obesity. There were no significant differences in concentrations MR-proADM, CT-proET-1, WBC, CRP, and PCT at baseline and the next 6 days between patients with and without obesity. Only MR-proADM changed significantly over time (p = 0.039). Also, BMI did not correlate with inflammatory biomarkers (MR-proADM rho = 0.150, p = 0.125, CT-proET-1 rho = 0.179, p = 0.067, WBC rho = -0.044, p = 0.654, CRP rho = 0.057, p = 0.564, PCT rho = 0.022, p = 0.842). Finally, no significant differences in time on a ventilator, ICU length of stay, and 28-day mortality between patients with or without obesity were observed.
+
+ CONCLUSIONS: In critically ill patients with confirmed SARS-CoV-2 pneumonia, obesity was not associated with differences in MR-proADM, and CT-proET-1, or impaired outcome.
+
+ TRIAL REGISTRATION: Netherlands Trial Register, NL8460. Copyright © 2022. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C-terminal proendothelin-1). 0 (Endothelin-1). 0 (Peptide Fragments). 0 (Procalcitonin). 0 (Protein Precursors). 0 (proadrenomedullin). 148498-78-6 (Adrenomedullin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Comparative Study. Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41366-022-01184-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+Oers&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Mid-regional+proadrenomedullin%2C+C-terminal+proendothelin-1+values%2C+and+disease+course+are+not+different+in+critically+ill+SARS-CoV-2+pneumonia+patients+with+obesity.&volume=46&issue=10&spage=1801&epage=1807&date=2022&doi=10.1038%2Fs41366-022-01184-2&pmid=35840771&sid=OVID:medline
+
+<458>
+Unique Identifier
+ 35839545
+Title
+ A double-blinded, randomized, parallel intervention to evaluate biomarker-based nutrition plans for weight loss: The PREVENTOMICS study.
+Source
+ Clinical Nutrition. 41(8):1834-1844, 2022 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aldubayan MA; Pigsborg K; Gormsen SMO; Serra F; Palou M; Galmes S; Palou-March A; Favari C; Wetzels M; Calleja A; Rodriguez Gomez MA; Castellnou MG; Caimari A; Galofre M; Sunol D; Escote X; Alcaide-Hidalgo JM; M Del Bas J; Gutierrez B; Krarup T; Hjorth MF; Magkos F
+Authors Full Name
+ Aldubayan, Mona A; Pigsborg, Kristina; Gormsen, Sophia M O; Serra, Francisca; Palou, Mariona; Galmes, Sebastia; Palou-March, Andreu; Favari, Claudia; Wetzels, Mart; Calleja, Alberto; Rodriguez Gomez, Miguel Angel; Castellnou, Maria Guirro; Caimari, Antoni; Galofre, Mar; Sunol, David; Escote, Xavier; Alcaide-Hidalgo, Juan Maria; M Del Bas, Josep; Gutierrez, Biotza; Krarup, Thure; Hjorth, Mads F; Magkos, Faidon.
+Institution
+ Aldubayan, Mona A. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark; King Saud bin Abdulaziz University for Health Sciences, College of Applied Medical Sciences, Riyadh, Saudi Arabia.
+ Pigsborg, Kristina. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark.
+ Gormsen, Sophia M O. R&D, Food & Culinary Department, Simple Feast, Copenhagen, Denmark.
+ Serra, Francisca. Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics, Biomarkers and Risk Evaluation-NuBE), University of the Balearic Islands (UIB), Health Research Institute of the Balearic Islands (IdISBa), CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Alimentomica S.L., Spin-off n.1 of the UIB Islands, Spain.
+ Palou, Mariona. Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics, Biomarkers and Risk Evaluation-NuBE), University of the Balearic Islands (UIB), Health Research Institute of the Balearic Islands (IdISBa), CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Alimentomica S.L., Spin-off n.1 of the UIB Islands, Spain.
+ Galmes, Sebastia. Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics, Biomarkers and Risk Evaluation-NuBE), University of the Balearic Islands (UIB), Health Research Institute of the Balearic Islands (IdISBa), CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Alimentomica S.L., Spin-off n.1 of the UIB Islands, Spain.
+ Palou-March, Andreu. Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics, Biomarkers and Risk Evaluation-NuBE), University of the Balearic Islands (UIB), Health Research Institute of the Balearic Islands (IdISBa), CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Alimentomica S.L., Spin-off n.1 of the UIB Islands, Spain.
+ Favari, Claudia. Human Nutrition Unit, Department of Food and Drug, University of Parma, Parma, Italy.
+ Wetzels, Mart. ONMI: Behaviour Change Technology, Eindhoven, the Netherlands.
+ Calleja, Alberto. R&D Department, Food Division, Grupo Carinsa, Sant Quirze del Valles, Barcelona, Spain.
+ Rodriguez Gomez, Miguel Angel. Eurecat, Centre Tecnologic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Universitat Rovira I Virgili-EURECAT, 43204 Reus, Spain.
+ Castellnou, Maria Guirro. Eurecat, Centre Tecnologic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Universitat Rovira I Virgili-EURECAT, 43204 Reus, Spain.
+ Caimari, Antoni. Eurecat, Centre Tecnologic de Catalunya, Biotechnology Area, Nutrition and Health Unit, Reus, Spain.
+ Galofre, Mar. Eurecat, Centre tecnologic de Catalunya, Digital Health Unit, Carrer de Bilbao, 72, 08005 Barcelona, Spain.
+ Sunol, David. Eurecat, Centre tecnologic de Catalunya, Digital Health Unit, Carrer de Bilbao, 72, 08005 Barcelona, Spain.
+ Escote, Xavier. Eurecat, Centre Tecnologic de Catalunya, Biotechnology Area, Nutrition and Health Unit, Reus, Spain.
+ Alcaide-Hidalgo, Juan Maria. Eurecat, Centre Tecnologic de Catalunya, Biotechnology Area, Nutrition and Health Unit, Reus, Spain.
+ M Del Bas, Josep. Eurecat, Centre Tecnologic de Catalunya, Biotechnology Area, Nutrition and Health Unit, Reus, Spain.
+ Gutierrez, Biotza. Eurecat, Centre Tecnologic de Catalunya, Biotechnology Area, Nutrition and Health Unit, Reus, Spain.
+ Krarup, Thure. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark; Department of Endocrinology, Bispebjerg and Frederiksberg Hospital, Tuborgvej, Hellerup, Denmark.
+ Hjorth, Mads F. Healthy Weight Centre, Novo Nordisk Foundation, Tuborg Havnevej 19, 2900, Hellerup, Denmark.
+ Magkos, Faidon. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark. Electronic address: fma@nexs.ku.dk.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Mass Index
+ Body Weight
+ Humans
+ Lipids
+ Obesity/th [Therapy]
+ *Obesity
+ Overweight/th [Therapy]
+ *Weight Loss
+Keyword Heading
+ Health-biomarkers
+ Metabolomics
+ Nutrigenetics
+ Obesity
+ Personalized nutrition
+ Precision nutrition
+ Weight management
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: Growing evidence suggests that biomarker-guided dietary interventions can optimize response to treatment. In this study, we evaluated the efficacy of the PREVENTOMCIS platform-which uses metabolomic and genetic information to classify individuals into different 'metabolic clusters' and create personalized dietary plans-for improving health outcomes in subjects with overweight or obesity.
+
+ METHODS: A 10-week parallel, double-blinded, randomized intervention was conducted in 100 adults (82 completers) aged 18-65 years, with body mass index >=27 but <40 kg/m2, who were allocated into either a personalized diet group (n = 49) or a control diet group (n = 51). About 60% of all food was provided free-of-charge. No specific instruction to restrict energy intake was given. The primary outcome was change in fat mass from baseline, evaluated by dual energy X-ray absorptiometry. Other endpoints included body weight, waist circumference, lipid profile, glucose homeostasis markers, inflammatory markers, blood pressure, physical activity, stress and eating behavior.
+
+ RESULTS: There were significant main effects of time (P < 0.01), but no group main effects, or time-by-group interactions, for the change in fat mass (personalized: -2.1 [95% CI -2.9, -1.4] kg; control: -2.0 [95% CI -2.7, -1.3] kg) and body weight (personalized: -3.1 [95% CI -4.1, -2.1] kg; control: -3.3 [95% CI -4.2, -2.4] kg). The difference between groups in fat mass change was -0.1 kg (95% CI -1.2, 0.9 kg, P = 0.77). Both diets resulted in significant improvements in insulin resistance and lipid profile, but there were no significant differences between groups.
+
+ CONCLUSION: Personalized dietary plans did not result in greater benefits over a generic, but generally healthy diet, in this 10-week clinical trial. Further studies are required to establish the soundness of different precision nutrition approaches, and translate this science into clinically relevant dietary advice to reduce the burden of obesity and its comorbidities.
+
+ CLINICAL TRIAL REGISTRY: ClinicalTrials.gov registry (NCT04590989). Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.clnu.2022.06.032
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aldubayan&issn=0261-5614&title=Clinical+Nutrition&atitle=A+double-blinded%2C+randomized%2C+parallel+intervention+to+evaluate+biomarker-based+nutrition+plans+for+weight+loss%3A+The+PREVENTOMICS+study.&volume=41&issue=8&spage=1834&epage=1844&date=2022&doi=10.1016%2Fj.clnu.2022.06.032&pmid=35839545&sid=OVID:medline
+
+<459>
+Unique Identifier
+ 35829866
+Title
+ Non-invasive evaluation of NAFLD and the contribution of genes: an MRI-PDFF-based cross-sectional study.
+Source
+ Hepatology International. 16(5):1035-1051, 2022 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang A; Zhu X; Zhang L; Zhang Y; Zhang D; Jin M; Niu J; Zhang H; Ding Y; Lv G
+Author NameID
+ Ding, Yanhua; ORCID: http://orcid.org/0000-0002-0498-8939
+Authors Full Name
+ Yang, Aruhan; Zhu, Xiaoxue; Zhang, Lei; Zhang, Yingwen; Zhang, Dezhi; Jin, Meishan; Niu, Junqi; Zhang, Huimao; Ding, Yanhua; Lv, Guoyue.
+Institution
+ Yang, Aruhan. Phase I Clinical Trial Unit, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China.
+ Zhu, Xiaoxue. Phase I Clinical Trial Unit, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China.
+ Zhang, Lei. Department of Radiology, First Hospital of Jilin University, Changchun, China.
+ Zhang, Yingwen. Department of Hepatology, First Hospital of Jilin University, Changchun, China.
+ Zhang, Dezhi. Department of Pathology, First Hospital of Jilin University, Changchun, China.
+ Jin, Meishan. Department of Pathology, First Hospital of Jilin University, Changchun, China.
+ Niu, Junqi. Department of Hepatology, First Hospital of Jilin University, Changchun, China.
+ Zhang, Huimao. Department of Radiology, First Hospital of Jilin University, Changchun, China.
+ Ding, Yanhua. Phase I Clinical Trial Unit, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China. dingyanh@jlu.edu.cn.
+ Lv, Guoyue. Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China. lvgy@jlu.edu.cn.
+MeSH Subject Headings
+ Biomarkers
+ Cross-Sectional Studies
+ Humans
+ Liver/dg [Diagnostic Imaging]
+ Liver/pa [Pathology]
+ Magnetic Resonance Imaging
+ Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity
+Keyword Heading
+ Digestive system disease
+ Hepatobiliary disorders
+ Liver dysfunction
+ Liver fat content
+ Liver steatosis
+ MRI-proton-density-fat-fraction (PDFF)
+ Metabolic fatty liver disease (MAFLD)
+ Non-alcoholic fatty liver disease (NAFLD)
+ Non-alcoholic steatohepatitis
+ Odds ratios
+ Single-nucleotide polymorphisms (SNP)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To investigate the clinical, laboratory and genetic features of NAFLD patients based on MRI-PDFF in China.
+
+ DESIGN: Patients with high ALT and with a diagnosis of fatty liver were included in this cross-sectional study. Fasting blood was collected to test biomarkers and SNPs. A total of 266 patients underwent MRI-PDFF and FibroScan examinations, and 38 underwent liver biopsy. Diagnostic models (decision tree, LASSO, and elastic net) were developed based on the diagnosis from MRI-PDFF reports.
+
+ RESULTS: Approximately, 1/3 of the patients were found to have NASH and fibrosis. After quantifying liver steatosis by MRI-PDFF (healthy: n = 47; mild NAFLD: n = 136; moderate/severe NAFLD: n = 83; liver fat content (LFC): 3.6% vs. 8.7% vs. 19.0%), most biomarkers showed significant differences among the three groups, and patients without obesity were found to have a similar LFC as those with obesity (11.1% vs. 12.3%). Models including biomarkers showed strong diagnostic ability (accuracy: 0.80-0.91). Variant alleles of PNPLA3, HSD17B13 and MBOAT7 were identified as genetic risk factors causing higher LFC (8.7% vs. 12.3%; 11.0% vs. 14.5%; 8.5% vs. 10.2%, p < 0.05); those with the UQCC1 rs878639 variant allele showed lower LFC (10.4% vs. 8.4%; OR = 0.58, p < 0.05). Patients with more risk alleles had higher LFCs (8.1% vs. 10.7% vs. 11.6% vs. 14.5%).
+
+ CONCLUSIONS: Based on MRI-PDFF, a combination of several specific biomarkers can accurately predict disease status. When the effects of genes on liver steatosis were first quantified by MRI-PDFF, the UQCC1 rs878639 G allele was identified as a protective factor, and the MBOAT7 T allele was identified as a risk only among nonobese individuals. Copyright © 2022. Asian Pacific Association for the Study of the Liver.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs12072-022-10355-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=1936-0533&title=Hepatology+International&atitle=Non-invasive+evaluation+of+NAFLD+and+the+contribution+of+genes%3A+an+MRI-PDFF-based+cross-sectional+study.&volume=16&issue=5&spage=1035&epage=1051&date=2022&doi=10.1007%2Fs12072-022-10355-2&pmid=35829866&sid=OVID:medline
+
+<460>
+Unique Identifier
+ 35815085
+Title
+ Estimation of elemental concentrations in the toenail of young Saudi females with obesity.
+Source
+ Journal of Medicine & Life. 15(5):601-605, 2022 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Muzafar H; Al-Hariri M
+Authors Full Name
+ Al-Muzafar, Hessah; Al-Hariri, Mohammed.
+Institution
+ Al-Muzafar, Hessah. Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
+ Al-Hariri, Mohammed. Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Cadmium/an [Analysis]
+ *Cadmium
+ Cross-Sectional Studies
+ Female
+ Humans
+ Ions/an [Analysis]
+ Male
+ Nails/ch [Chemistry]
+ Nails/me [Metabolism]
+ *Nails
+ Obesity/ep [Epidemiology]
+ Saudi Arabia/ep [Epidemiology]
+Keyword Heading
+ Obesity
+ Saudi
+ elemental concentrations
+ elements
+ females
+ toenail
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Elemental homeostasis is essential for maintaining normal metabolic processes. Elements in the toenails are now considered in the diagnosis or screening and used as biomarkers of several metabolic disorders. The incidence of obesity is more prevalent in females than males globally. At the same time, females appeared more susceptible to elemental alterations than males. This study aimed to evaluate the variation in the levels of several elements in toenails as possible biomarkers of health conditions associated with obesity in young Saudi females. A cross-sectional study was performed, between February-November 2019. The study enrolled 79 young females divided into two groups: participants with obesity (n=39) and non-obese (n=40). The toenail was analyzed to estimate Fe, I, K, Na, Cd, Cr, Mn, Ca, Mg, Cu, Co, and Se levels. The study showed a significant elevation in the levels of Fe, Ca, K, and Na in the toenail sample of female participants with obesity compared to the non-obese group. The levels of Mn, Cd, Co, Cu, and Cr, were significantly decreased in the toenail of participants with obesity. Moreover, other elements (i.e., Mg, I, and Se) were not significantly lower in the female group with obesity. Our findings confirmed the alterations of several elements among Saudi females with obesity. The toenail elemental analysis may become a useful diagnostic technique in monitoring the nutritional status, predicting some metabolic disorders, and environmental exposure. Copyright © 2022 JOURNAL of MEDICINE and LIFE.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ions). 00BH33GNGH (Cadmium).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.25122%2fjml-2022-0017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Muzafar&issn=1844-122X&title=Journal+of+Medicine+%26+Life&atitle=Estimation+of+elemental+concentrations+in+the+toenail+of+young+Saudi+females+with+obesity.&volume=15&issue=5&spage=601&epage=605&date=2022&doi=10.25122%2Fjml-2022-0017&pmid=35815085&sid=OVID:medline
+
+<461>
+Unique Identifier
+ 35805627
+Title
+ Effects of Intermittent Energy Restriction Alone and in Combination with Sprint Interval Training on Body Composition and Cardiometabolic Biomarkers in Individuals with Overweight and Obesity.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 19(13), 2022 06 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cooke MB; Deasy W; Ritenis EJ; Wilson RA; Stathis CG
+Author NameID
+ Cooke, Matthew B; ORCID: https://orcid.org/0000-0002-4978-4294
+ Deasy, William; ORCID: https://orcid.org/0000-0003-1864-9759
+ Stathis, Christos G; ORCID: https://orcid.org/0000-0003-0064-9523
+Authors Full Name
+ Cooke, Matthew B; Deasy, William; Ritenis, Elya J; Wilson, Robin A; Stathis, Christos G.
+Institution
+ Cooke, Matthew B. College of Health and Biomedicine, Victoria University, Melbourne, VIC 3000, Australia.
+ Cooke, Matthew B. Department of Health Sciences and Biostatistics, Swinburne University of Technology, Melbourne, VIC 3122, Australia.
+ Cooke, Matthew B. Australian Institute for Musculoskeletal Science (AIMSS), Western Health, Melbourne, VIC 3021, Australia.
+ Deasy, William. College of Health and Biomedicine, Victoria University, Melbourne, VIC 3000, Australia.
+ Deasy, William. College of Clinical Sciences, Central Queensland University, Rockhampton, QLD 4701, Australia.
+ Ritenis, Elya J. Department of Health Sciences and Biostatistics, Swinburne University of Technology, Melbourne, VIC 3122, Australia.
+ Wilson, Robin A. College of Health and Biomedicine, Victoria University, Melbourne, VIC 3000, Australia.
+ Wilson, Robin A. Australian Institute for Musculoskeletal Science (AIMSS), Western Health, Melbourne, VIC 3021, Australia.
+ Stathis, Christos G. College of Health and Biomedicine, Victoria University, Melbourne, VIC 3000, Australia.
+ Stathis, Christos G. Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Composition
+ *Cardiovascular Diseases
+ Female
+ *High-Intensity Interval Training
+ Humans
+ Male
+ Obesity
+ Overweight
+Keyword Heading
+ body composition
+ cardiorespiratory fitness
+ intermittent fasting
+ metabolic
+ sprint exercise
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The popularity of intermittent fasting (IF) and high intensity (sprint) interval training (SIT) has increased in recent years amongst the general public due to their purported health benefits and feasibility of incorporation into daily life. The number of scientific studies investigating these strategies has also increased, however, very few have examined the combined effects, especially on body composition and cardiometabolic biomarkers, which is the primary aim of this investigation. A total of thirty-four male and female participants (age: 35.4 +/- 8.4 y, body mass index (BMI): 31.3 +/- 3.5 kg/m2, aerobic capacity (VO2peak) 27.7 +/- 7.0 mL.kg-1.min-1) were randomized into one of three 16-week interventions: (1) 5:2 IF (2 non-consecutive days of fasting per week, 5 days on ad libitum eating), (2) supervised SIT (3 bouts per week of 20s cycling at 150% VO2peak followed by 40 s of active rest, total 10 min duration), and (3) a combination of both interventions. Body composition, haemodynamic and VO2peak were measured at 0, 8 and 16 weeks. Blood samples were also taken and analysed for lipid profiles and markers of glucose regulation. Both IF and IF/SIT significantly decreased body weight, fat mass and visceral fat compared to SIT only (p < 0.05), with no significant differences between diet and diet + exercise combined. The effects of diet and/or exercise on cardiometabolic biomarkers were mixed. Only exercise alone or with IF significantly increased cardiorespiratory fitness. The results suggest that energy restriction was the main driver of body composition enhancement, with little effect from the low volume SIT. Conversely, to achieve benefits in cardiorespiratory fitness, exercise is required.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijerph19137969
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cooke&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Effects+of+Intermittent+Energy+Restriction+Alone+and+in+Combination+with+Sprint+Interval+Training+on+Body+Composition+and+Cardiometabolic+Biomarkers+in+Individuals+with+Overweight+and+Obesity.&volume=19&issue=13&spage=&epage=&date=2022&doi=10.3390%2Fijerph19137969&pmid=35805627&sid=OVID:medline
+
+<462>
+Unique Identifier
+ 35798137
+Title
+ Effects of WB-EMS and protein supplementation on body composition, physical function, metabolism and inflammatory biomarkers in middle-aged and elderly patients with sarcopenic obesity: A meta-analysis of randomized controlled trials.
+Source
+ Experimental Gerontology. 166:111886, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang JM; Luo Y; Zhang JH; Liu QQ; Zhu Q; Ye H; Niu YL; Huang H; Xie HY; Long Y; Wang MY
+Authors Full Name
+ Yang, Jia-Ming; Luo, Yun; Zhang, Jia-Hong; Liu, Qin-Qin; Zhu, Qiang; Ye, Hua; Niu, Yan-Long; Huang, Hui; Xie, Hui-Yong; Long, Yi; Wang, Mao-Yuan.
+Institution
+ Yang, Jia-Ming. Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China; Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China.
+ Luo, Yun. Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China; Ganzhou Key Laboratory of Rehabilitation Medicine, 341000 Ganzhou City, Jiangxi Province, China.
+ Zhang, Jia-Hong. Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China.
+ Liu, Qin-Qin. Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China.
+ Zhu, Qiang. Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China.
+ Ye, Hua. Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China.
+ Niu, Yan-Long. Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China; Ganzhou Key Laboratory of Rehabilitation Medicine, 341000 Ganzhou City, Jiangxi Province, China.
+ Huang, Hui. Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China.
+ Xie, Hui-Yong. Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China.
+ Long, Yi. Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China.
+ Wang, Mao-Yuan. Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China; Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou City, Jiangxi Province, China; Ganzhou Key Laboratory of Rehabilitation Medicine, 341000 Ganzhou City, Jiangxi Province, China. Electronic address: wmy.gmu.kf@gmail.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Body Composition
+ Dietary Supplements
+ Humans
+ Middle Aged
+ Obesity/th [Therapy]
+ Randomized Controlled Trials as Topic
+ Sarcopenia/th [Therapy]
+ *Sarcopenia
+Keyword Heading
+ Meta-analysis
+ Protein supplementation
+ Sarcopenic obesity
+ WB-EMS
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The patients with sarcopenic obesity (SO) have the characteristics of both sarcopenia and obesity, that is, less muscle mass and increased fat mass, and their morbidity, disability and mortality are higher than patients with sarcopenia or obesity alone.
+
+ OBJECTIVES: To investigate the effects of whole-body electromyostimulation (WB-EMS) training and protein supplementation intervention on body composition, physical function, metabolism and inflammatory biomarkers in middle-aged and elderly patients with SO.
+
+ METHODS: We searched for randomized controlled trials in seven databases, including PubMed, Web of Science, Embase, Cochrane Library, Scopus, SinoMed, and CNKI as of July 3, 2021. The methodological quality of each included study was assessed using the Physiotherapy Evidence Database (PEDro) scale. The Cochrane Risk of Bias Tool was used to assess the risk of bias. Statistical analysis was performed using Review Manager 5.3.
+
+ RESULTS: Eleven randomized controlled studies with a total of 779 participants were included in this meta-analysis. WB-EMS training improved sarcopenia Z-score (MD = -1.52, 95 % CI: -2.27, -0.77, P < 0.0001) and waist circumference (WC) (MD = -1.41, 95 % CI: -2.62, -0.20, P = 0.02), and increased skeletal muscle mass index (SMI) (MD = 1.27, 95 % CI: 0.66,1.88, P < 0.0001) and appendicular skeletal muscle mass (ASMM) (MD = 0.68, 95 % CI: 0.08, 1.27, P = 0.03). Protein supplementation intervention reduced body fat rate (BF%) (MD = -1.28, 95 % CI: -1.88, -0.68, P < 0.0001, I2 = 0 %), total body fat (TBF) (MD = -0.98, 95 % CI: -1.65, -0.31, P = 0.004, I2 = 0 %) and trunk body fat mass (TBFM) (MD = -0.50, 95 % CI: -0.94, -0.06, P = 0.03, I2 = 0 %), and increased grip strength (GS) (MD = 1.13, 95 % CI: 0.06, 2.21, P = 0.04, I2 = 0 %). The combination of WB-EMS and protein supplements is beneficial to most body components and physical functions, such as SMI (MD = 1.21, 95 % CI: 0.73, 1.51, P < 0.00001, I2 = 0 %), GS (MD = 1.60, 95 % CI: 0.80, 2.40, P < 0.0001, I2 = 45 %) and walking speed (WS) (MD = 0.04, 95 % CI: 0.02, 0.06, P < 0.0001, I2 = 49 %). Compared with protein supplementation alone, WB-EMS could have an additional beneficial effect on BF% (MD = -0.92, 95 % CI: -1.80, -0.04, P = 0.04) and WC (MD = -1.03, 95 % CI: -1.70, -0.36, P = 0.003). Nevertheless, the addition of protein supplements did not provide any additional benefit compared with WB-EMS alone. In addition, there was almost no positive effect of WB-EMS and protein supplements on metabolic and inflammatory biomarkers.
+
+ CONCLUSIONS: As things stand, protein supplementation intervention can effectively reduce body fat percentage, fat mass, and increase grip strength in SO patients. Both WB-EMS and protein supplementation intervention had no significant effects on metabolic and inflammatory biomarkers. WB-EMS combined with protein supplementation intervention was beneficial for SO patients in many ways. Due to the small number of studies, further studies are needed to confirm the efficacy of WB-EMS alone or in combination with protein supplementation intervention in SO patients.
+
+ REGISTRATION NUMBER: INPLASY202190096 DOI:10.37766/inplasy2021.9.0096. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.exger.2022.111886
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=0531-5565&title=Experimental+Gerontology&atitle=Effects+of+WB-EMS+and+protein+supplementation+on+body+composition%2C+physical+function%2C+metabolism+and+inflammatory+biomarkers+in+middle-aged+and+elderly+patients+with+sarcopenic+obesity%3A+A+meta-analysis+of+randomized+controlled+trials.&volume=166&issue=&spage=111886&epage=&date=2022&doi=10.1016%2Fj.exger.2022.111886&pmid=35798137&sid=OVID:medline
+
+<463>
+Unique Identifier
+ 35796657
+Title
+ Associations of Hemoglobin Adducts of Acrylamide and Glycidamide with Prevalent Metabolic Syndrome in a Nationwide Population-Based Study.
+Source
+ Journal of Agricultural & Food Chemistry. 70(28):8755-8766, 2022 Jul 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wan X; Zhu F; Zhuang P; Liu X; Zhang L; Jia W; Jiao J; Xu C; Zhang Y
+Author NameID
+ Zhang, Yu; ORCID: https://orcid.org/0000-0003-1025-906X
+Authors Full Name
+ Wan, Xuzhi; Zhu, Fanghuan; Zhuang, Pan; Liu, Xiaohui; Zhang, Lange; Jia, Wei; Jiao, Jingjing; Xu, Chengfu; Zhang, Yu.
+Institution
+ Wan, Xuzhi. College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University; Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
+ Zhu, Fanghuan. College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University; Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
+ Zhuang, Pan. College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University; Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
+ Liu, Xiaohui. Department of Nutrition, School of Public Health, Department of Clinical Nutrition of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
+ Zhang, Lange. Department of Nutrition, School of Public Health, Department of Clinical Nutrition of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
+ Jia, Wei. College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University; Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
+ Jiao, Jingjing. Department of Nutrition, School of Public Health, Department of Clinical Nutrition of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
+ Xu, Chengfu. Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China.
+ Zhang, Yu. College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University; Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
+ Zhang, Yu. Ningbo Research Institute, Zhejiang University, Ningbo 315100, Zhejiang, China.
+ Zhang, Yu. Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, Zhejiang, China.
+MeSH Subject Headings
+ Acrylamide/me [Metabolism]
+ Adult
+ Biomarkers
+ Epoxy Compounds
+ Glucose
+ Hemoglobins/me [Metabolism]
+ Humans
+ *Hypertriglyceridemia
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome
+ Obesity
+ Obesity, Abdominal/ep [Epidemiology]
+Keyword Heading
+ acrylamide
+ biomarkers
+ diet
+ hemoglobin adducts
+ metabolic syndrome
+ population-based study
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Environmental and dietary exposures to acrylamide (AA) have been linked with various metabolic-related outcomes, but the results are mixed. However, the association between long-term exposure to AA and the prevalence of metabolic syndrome (MetS) remains unknown. In this study, we aimed to assess the relationship between hemoglobin adducts of AA, biomarkers of internal exposure to AA, and MetS prevalence among a U.S. nationwide population. MetS patients were defined by meeting three or more of the following five characteristics: elevated blood pressure, high fasting glucose, abdominal obesity, hypertriglyceridemia, and lower high-density lipoprotein cholesterol (HDL-C). Multivariate-adjusted logistic regression models and restricted cubic spline models were used to analyze the associations between AA hemoglobin biomarkers and MetS prevalence. A total of 1552 MetS cases were documented. After adjustment for the potential confounders, the odds ratios (95% confidence intervals) of MetS prevalence in the highest quartile of AA hemoglobin biomarkers were 0.60 (0.40-0.89), 1.26 (0.84-1.89), 0.93 (0.71-1.21), and 1.61 (1.18-2.20) for HbAA, HbGA, the sum of HbAA and HbGA (HbAA + HbGA), and the ratio of HbGA to HbAA (HbGA/HbAA), compared with the lowest quartile, respectively. HbAA was significantly and inversely associated with blood pressure, fasting glucose, abdominal obesity, hypertriglyceridemia, and low HDL-C, while the HbGA/HbAA ratio was also positively associated with abdominal obesity, hypertriglyceridemia, and low HDL-C. The restricted cubic spline models revealed a positive relationship between the HbGA/HbAA ratio and the prevalence of MetS, while the HbAA level was inversely associated with MetS prevalence. Our current findings provided epidemiological evidence that HbAA and the HbGA/HbAA ratio were significantly associated with MetS prevalence among general U.S. adults. Further studies should be conducted to examine the association between internal exposure to AA and MetS prevalence.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Epoxy Compounds). 0 (Hemoglobins). 20R035KLCI (Acrylamide). 6G5ELX5XYN (glycidamide). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1021%2facs.jafc.2c03016
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wan&issn=0021-8561&title=Journal+of+Agricultural+%26+Food+Chemistry&atitle=Associations+of+Hemoglobin+Adducts+of+Acrylamide+and+Glycidamide+with+Prevalent+Metabolic+Syndrome+in+a+Nationwide+Population-Based+Study.&volume=70&issue=28&spage=8755&epage=8766&date=2022&doi=10.1021%2Facs.jafc.2c03016&pmid=35796657&sid=OVID:medline
+
+<464>
+Unique Identifier
+ 35793549
+Title
+ Impact of obesity and white adipose tissue inflammation on the omental microenvironment in endometrial cancer.
+Source
+ Cancer. 128(18):3297-3309, 2022 09 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moukarzel LA; Ferrando L; Stylianou A; Lobaugh S; Wu M; Nobre SP; Iasonos A; Zoppoli G; Giri DD; Abu-Rustum NR; Broach VA; Iyengar NM; Weigelt B; Makker V
+Author NameID
+ Iyengar, Neil M; ORCID: https://orcid.org/0000-0002-9773-5235
+ Weigelt, Britta; ORCID: https://orcid.org/0000-0001-9927-1270
+ Makker, Vicky; ORCID: https://orcid.org/0000-0001-9793-7614
+Authors Full Name
+ Moukarzel, Lea A; Ferrando, Lorenzo; Stylianou, Anthe; Lobaugh, Stephanie; Wu, Michelle; Nobre, Silvana Pedra; Iasonos, Alexia; Zoppoli, Gabriele; Giri, Dilip D; Abu-Rustum, Nadeem R; Broach, Vance A; Iyengar, Neil M; Weigelt, Britta; Makker, Vicky.
+Institution
+ Moukarzel, Lea A. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Ferrando, Lorenzo. Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Ferrando, Lorenzo. Department of Internal Medicine, University of Genoa, Genoa, Italy.
+ Stylianou, Anthe. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Lobaugh, Stephanie. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Wu, Michelle. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Nobre, Silvana Pedra. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Zoppoli, Gabriele. Department of Internal Medicine, University of Genoa, Genoa, Italy.
+ Zoppoli, Gabriele. IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
+ Giri, Dilip D. Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Abu-Rustum, Nadeem R. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Abu-Rustum, Nadeem R. Department of Obstetrics/Gynecology, Weill Cornell Medical College, New York, New York, USA.
+ Broach, Vance A. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Broach, Vance A. Department of Obstetrics/Gynecology, Weill Cornell Medical College, New York, New York, USA.
+ Iyengar, Neil M. Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Iyengar, Neil M. Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
+ Weigelt, Britta. Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+ Makker, Vicky. Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
+ Makker, Vicky. Gynecologic Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
+MeSH Subject Headings
+ Adipose Tissue, White
+ Biomarkers
+ *Endometrial Neoplasms
+ Female
+ Humans
+ Inflammation
+ *Metabolic Syndrome
+ Obesity
+ Tumor Microenvironment
+Keyword Heading
+ RNA-sequencing
+ endometrial cancer
+ obesity
+ tissue inflammation
+ white adipose
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: A complex relationship between adipose tissue and malignancy, involving an inflammatory response, has been reported. The goal of this work was to assess the prevalence of white adipose tissue (WAT) inflammation in patients with endometrial cancer (EC), and the association with circulating inflammation markers. Furthermore, the aim was to characterize the pathways activated in and the cell type composition of adipose tissue in patients with EC.
+
+ METHODS: Adipose tissue and blood samples were prospectively collected from 101 patients with EC at initial surgery. WAT inflammation was determined based on adipocytes surrounded by macrophages forming crown-like structures. Circulating levels of metabolic syndrome-associated and inflammatory markers were quantified. RNA-sequencing was performed on adipose samples (n = 55); differential gene expression, pathway, and cellular decomposition analyses were performed using state-of-the-art bioinformatics methods.
+
+ RESULTS: WAT inflammation was identified in 46 (45.5%) of 101 EC patients. Dyslipidemia, hypertension, and diabetes mellitus were significantly associated with WAT inflammation (p < .05). WAT inflammation was associated with greater body mass index (p < .001) and higher circulating levels of leptin, high-sensitivity C-reactive protein, and interleukin-6, as well as lower levels of adiponectin and sex hormone-binding globulin (p < .05). Transcriptomic analysis demonstrated increased levels of proinflammatory and pro-neoplastic-related gene expression in inflamed omental adipose tissue.
+
+ CONCLUSIONS: WAT inflammation is associated with metabolic syndrome, obesity, and inflammatory markers, as well as increased expression of proinflammatory and proneoplastic genes. Copyright © 2022 American Cancer Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1002%2fcncr.34356
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moukarzel&issn=0008-543X&title=Cancer&atitle=Impact+of+obesity+and+white+adipose+tissue+inflammation+on+the+omental+microenvironment+in+endometrial+cancer.&volume=128&issue=18&spage=3297&epage=3309&date=2022&doi=10.1002%2Fcncr.34356&pmid=35793549&sid=OVID:medline
+
+<465>
+Unique Identifier
+ 35790777
+Title
+ Meeting 24-h movement guidelines and markers of adiposity in adults from eight Latin America countries: the ELANS study.
+Source
+ Scientific Reports. 12(1):11382, 2022 07 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ferrari G; Cristi-Montero C; Drenowatz C; Kovalskys I; Gomez G; Rigotti A; Cortes LY; Yepez Garcia M; Liria-Dominguez MR; Herrera-Cuenca M; Peralta M; Marques A; Marconcin P; da Costa RF; Leme ACB; Farias-Valenzuela C; Ferrero-Hernandez P; Fisberg M
+Authors Full Name
+ Ferrari, Gerson; Cristi-Montero, Carlos; Drenowatz, Clemens; Kovalskys, Irina; Gomez, Georgina; Rigotti, Attilio; Cortes, Lilia Yadira; Yepez Garcia, Martha; Liria-Dominguez, Maria Reyna; Herrera-Cuenca, Marianella; Peralta, Miguel; Marques, Adilson; Marconcin, Priscila; da Costa, Roberto Fernandes; Leme, Ana Carolina B; Farias-Valenzuela, Claudio; Ferrero-Hernandez, Paloma; Fisberg, Mauro.
+Institution
+ Ferrari, Gerson. Escuela de Ciencias de la Actividad Fisica, el Deporte y la Salud, Universidad de Santiago de Chile (USACH), Las Sophoras 175, Estacion Central, Santiago, Chile. gerson.demoraes@usach.cl.
+ Ferrari, Gerson. Laboratorio de Rendimiento Humano, Grupo de Estudio en Educacion, Actividad Fisica y Salud (GEEAFyS), Universidad Catolica del Maule, Talca, Chile. gerson.demoraes@usach.cl.
+ Cristi-Montero, Carlos. IRyS Group, Physical Education School, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile.
+ Drenowatz, Clemens. Division of Sport, Physical Activity and Health, University of Education Upper Austria, Linz, Austria.
+ Kovalskys, Irina. Carrera de Nutricion, Facultad de Ciencias Medicas, Pontificia Universidad Catolica Argentina, Buenos Aires, Argentina.
+ Gomez, Georgina. Departamento de Bioquimica, Escuela de Medicina, Universidad de Costa Rica, San Jose, Costa Rica.
+ Rigotti, Attilio. Centro de Nutricion Molecular y Enfermedades Cronicas, Departamento de Nutricion, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Catolica, Santiago, Chile.
+ Cortes, Lilia Yadira. Departamento de Nutricion y Bioquimica, Pontificia Universidad Javeriana, Bogota, Colombia.
+ Yepez Garcia, Martha. Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, Ecuador.
+ Liria-Dominguez, Maria Reyna. Instituto de Investigacion Nutricional, La Molina, Lima, Peru.
+ Liria-Dominguez, Maria Reyna. Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru.
+ Herrera-Cuenca, Marianella. Centro de Estudios del Desarrollo, Universidad Central de Venezuela (CENDES-UCV)/Fundacion Bengoa, Caracas, Venezuela.
+ Peralta, Miguel. CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
+ Peralta, Miguel. ISAMB, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
+ Marques, Adilson. CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
+ Marques, Adilson. ISAMB, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
+ Marconcin, Priscila. Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.
+ da Costa, Roberto Fernandes. Physical Education Department, Health Sciences Centre, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
+ Leme, Ana Carolina B. Centro de Excelencia em Nutricao e Dificuldades Alimentaes (CENDA), Instituto Pensi, Fundacao Jose Luiz Egydio Setubal, Hospital Infantil Sabara, Sao Paulo, Brazil.
+ Leme, Ana Carolina B. Family Relations and Applied Nutrition, University of Guelph, Guelph, ON, N1G 2W1, Canada.
+ Leme, Ana Carolina B. Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil.
+ Farias-Valenzuela, Claudio. Instituto del Deporte, Universidad de las Americas, 9170022, Santiago, Chile.
+ Ferrero-Hernandez, Paloma. Facultad de Educacion y Cultura, Universidad SEK, Santiago, Chile.
+ Fisberg, Mauro. Centro de Excelencia em Nutricao e Dificuldades Alimentaes (CENDA), Instituto Pensi, Fundacao Jose Luiz Egydio Setubal, Hospital Infantil Sabara, Sao Paulo, Brazil.
+ Fisberg, Mauro. Departamento de Pediatria da, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers
+ Cross-Sectional Studies
+ *Exercise
+ Female
+ Humans
+ Latin America/ep [Epidemiology]
+ Male
+ Obesity/ep [Epidemiology]
+Abstract
+ This study aimed to compare compliance with 24-h movement guidelines across countries and examine the associations with markers of adiposity in adults from eight Latin American countries. The sample consisted of 2338 adults aged 18-65 years. Moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB) data were objectively measured using accelerometers. Sleep duration was self-reported using a daily log. Body mass index and waist circumference were assessed as markers of adiposity. Meeting the 24-h movement guidelines was defined as >= 150 min/week of MVPA; <= 8 h/day of SB; and between 7 and 9 h/day of sleep. The number of guidelines being met was 0.90 (95% CI 0.86, 0.93) with higher value in men than women. We found differences between countries. Meeting two and three movement guidelines was associated with overweight/obesity (OR: 0.75, 95% CI 0.58, 0.97 and OR: 0.69, 95% CI 0.51, 0.85, respectively) and high waist circumference (OR: 0.74, 95% CI 0.56, 0.97 and OR: 0.77, 95% CI 0.62, 0.96). Meeting MVPA and SB recommendations were related to reduced adiposity markers but only in men. Future research is needed to gain insights into the directionality of the associations between 24-h movement guidelines compliance and markers of adiposity but also the mechanisms underlying explaining differences between men and women. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41598-022-15504-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ferrari&issn=2045-2322&title=Scientific+Reports&atitle=Meeting+24-h+movement+guidelines+and+markers+of+adiposity+in+adults+from+eight+Latin+America+countries%3A+the+ELANS+study.&volume=12&issue=1&spage=11382&epage=&date=2022&doi=10.1038%2Fs41598-022-15504-z&pmid=35790777&sid=OVID:medline
+
+<466>
+Unique Identifier
+ 35790683
+Title
+ Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study.
+Source
+ Journal of Endocrinological Investigation. 45(11):2123-2130, 2022 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang Y; Dilimulati D; Chen D; Cai M; You H; Sun H; Gao X; Shao X; Zhang M; Qu S
+Author NameID
+ Zhang, M; ORCID: http://orcid.org/0000-0002-8445-1954
+ Qu, S; ORCID: http://orcid.org/0000-0003-0811-7070
+Authors Full Name
+ Zhang, Y; Dilimulati, D; Chen, D; Cai, M; You, H; Sun, H; Gao, X; Shao, X; Zhang, M; Qu, S.
+Institution
+ Zhang, Y. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
+ Dilimulati, D. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
+ Chen, D. Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
+ Cai, M. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
+ You, H. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
+ Sun, H. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
+ Gao, X. Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
+ Shao, X. Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China. shaoxiaowen1026@163.com.
+ Zhang, M. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China. mannazhang@126.com.
+ Qu, S. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
+MeSH Subject Headings
+ Alanine Transaminase
+ Aspartate Aminotransferases
+ Biomarkers
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ China/ep [Epidemiology]
+ Cholesterol, HDL
+ Female
+ Fibrinogen
+ Glycated Hemoglobin/an [Analysis]
+ Hormones
+ Humans
+ Insulin
+ *Insulin Resistance
+ Obesity/co [Complications]
+ *Polycystic Ovary Syndrome
+ Uric Acid
+Keyword Heading
+ Aminotransferase
+ Fibrinogen-like protein 1 (FGL-1)
+ Insulin resistance (IR)
+ Obesity
+ Polycystic ovary syndrome (PCOS)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: To investigate the relationship between fibrinogen-like protein 1 (FGL-1) concentrations and various metabolic characteristics in patients with polycystic ovary syndrome (PCOS) and explore whether FGL-1 could be a predictive biomarker for PCOS.
+
+ METHODS: This case-control study included 136 patients with PCOS and 34 normal controls recruited in the Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital between May 2017 and June 2021. Anthropometric characteristics, metabolic parameters, and reproductive hormones were collected. Serum FGL-1 measurement was conducted using enzyme-linked immunosorbent assay (ELISA) kits.
+
+ RESULTS: Serum FGL-1 concentrations were higher in patients with PCOS than in control subjects in body mass index (BMI) subgroups, insulin resistance (IR) subgroups, and hepatic function subgroups, respectively. Serum FGL-1 concentrations were significantly associated with BMI, glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein cholesterol (HDL-c), and serum uric acid (SUA) in all individuals. The receiver operating characteristic (ROC) curve analysis revealed that the best cutoff value for FGL-1 levels to predict PCOS was 21.02 ng/ml with a sensitivity of 74.3% and a specificity of 70.6%. Both univariate and multiple logistic regressions indicated that the odds ratio (OR) for PCOS significantly increased in the subjects with high levels of FGL-1.
+
+ CONCLUSION: In our study, FGL-1 was associated with serum aminotransferase and various metabolic indexes. Moreover, the high risk of PCOS was independently associated with the increased FGL-1 levels, which suggested that FGL-1 could be a predictive biomarker for PCOS. Copyright © 2022. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (FGL1 protein, human). 0 (Glycated Hemoglobin A). 0 (Hormones). 0 (Insulin). 268B43MJ25 (Uric Acid). 9001-32-5 (Fibrinogen). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs40618-022-01844-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Serum+fibrinogen-like+protein+1+as+a+novel+biomarker+in+polycystic+ovary+syndrome%3A+a+case-control+study.&volume=45&issue=11&spage=2123&epage=2130&date=2022&doi=10.1007%2Fs40618-022-01844-0&pmid=35790683&sid=OVID:medline
+
+<467>
+Unique Identifier
+ 35780711
+Title
+ Meteorin-like protein (Metrnl): A metabolic syndrome biomarker and an exercise mediator. [Review]
+Source
+ Cytokine. 157:155952, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alizadeh H
+Authors Full Name
+ Alizadeh, Hamid.
+Institution
+ Alizadeh, Hamid. Exercise Physiology, University of Mazandaran, Babolsar, Mazandaran, Iran. Electronic address: h.alizadeh@stu.umz.ac.ir.
+MeSH Subject Headings
+ Biomarkers
+ *Diabetes Mellitus, Type 2
+ *Heart Diseases
+ Humans
+ Inflammation
+ *Insulin Resistance
+ *Metabolic Syndrome
+ Obesity/me [Metabolism]
+Keyword Heading
+ A clinical biomarker
+ An exercise mediator
+ Cardiometabolic diseases (CMDs)
+ Metabolic syndrome (MetS)
+ Meteorin-like protein (Metrnl)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Metrnl is a secreted protein able to activate different intracellular signaling pathways in adipocytes, macrophages, myocytes and cardiomyocytes with physiological effects of the browning of white adipose tissue (BWT), insulin sensitivity, inflammation inhibition, skeletal muscle regeneration and heart protection. Shown to be regulated by obesity, diabetes, caloric restriction, weight loss and heart diseases, Metrnl is definitely involved in metabolic turbulences, and may play roles in metabolic syndrome (MetS). However, due to the conflicting data yielded, Metrnl is still far from clinical application as a diagnostic and/or a therapeutic agent or even a therapeutic target in MetS-related diseases such as type 2 diabetes (T2D) and obesity. Nevertheless, blood Metrnl levels as well as Metrnl as a cardiokine have been reported to play cardioprotective roles against heart diseases. Considering the established metabolic and anti-inflammatory hallmarks, exercise-induced Metrnl (as a myokine) is regarded as an exercise mediator in improving obesity-induced complications such as insulin resistance, T2D and inflammation. Besides, due to its healing role in muscle damage, Metrnl is also a potential therapeutic candidate to enhance regeneration with ageing or other inflammatory myopathies like Duchenne muscular dystrophy (DMD). Therefore, there are still many exercise-related questions unanswered on Metrnl, such as Metrnl-mediated fat browning in humans, exercise effects on heart Metrnl production and secretion and the effects of other exercise-induced skeletal muscle stressors like hypoxia and oxidative in Metrnl production other than exercise-induced muscle damage. Copyright © 2022 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.cyto.2022.155952
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alizadeh&issn=1043-4666&title=Cytokine&atitle=Meteorin-like+protein+%28Metrnl%29%3A+A+metabolic+syndrome+biomarker+and+an+exercise+mediator.&volume=157&issue=&spage=155952&epage=&date=2022&doi=10.1016%2Fj.cyto.2022.155952&pmid=35780711&sid=OVID:medline
+
+<468>
+Unique Identifier
+ 35780339
+Title
+ Relationship between Body Mass Index and Serum Alanine Transaminase Concentration in Obese Female.
+Source
+ Mymensingh Medical Journal: MMJ. 31(3):600-605, 2022 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Meherubin I; Nessa A; Huda MN; Naznen F; Afroz L; Mumu NS; Rukunuzzaman M; Yeasmin F; Sharmin A; Chowdhury R
+Authors Full Name
+ Meherubin, I; Nessa, A; Huda, M N; Naznen, F; Afroz, L; Mumu, N S; Rukunuzzaman, M; Yeasmin, F; Sharmin, A; Chowdhury, R.
+Institution
+ Meherubin, I. Dr Iffath Meherubin, Assistant Professor, Department of Physiology, Sheikh Hasina Medical College, Jamalpur, Bangladesh; E-mail: dr.imzemin@gmail.com.
+MeSH Subject Headings
+ Adult
+ Alanine Transaminase/bl [Blood]
+ *Alanine Transaminase
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Humans
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ *Obesity
+Abstract
+ The serum Alanine Transaminase (ALT) activity has been regarded as a reliable and sensitive marker of liver disease. In the context of obesity ALT may also be a good indicator of overall health. Obesity has been reported as a risk factor associated with elevation of ALT, which is a surrogate marker of Non-alcoholic fatty liver disease (NAFLD). Elevated ALT may correlate with the severity of NAFLD in obese female. This study was done to evaluate the changes of serum ALT in obese female age ranged 30-60 years in comparison to normal healthy female of same age. At the same time we can know the relationship between body mass index and serum ALT concentration in obese female. This analytical cross-sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from January 2020 to December 2020. A total number of 100 female subjects were included in this study. Among them fifty (50) normal healthy female were taken as control group (Group I) and fifty (50) obese female were taken as study group (Group II). The level of serum ALT was determined by Ultra violet (UV) method. Data were expressed as mean+/-SD and statistical significance of difference among the group was calculated by unpaired Student's 't' test. Pearson's correlation coefficient test was done to find the correlation of serum ALT with BMI by using SPSS (version 21.0). During interpretation of results, p values of <0.001 were considered as statistically highly significant. In this study, serum level of ALT was significantly higher (p<0.001) in obese female compared to those of healthy control female. In addition, there is a positive correlation of serum ALT with BMI. From the results of the present study, it can be concluded that, elevated ALT was significantly associated with high BMI as well as with other feature of NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&AN=35780339
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Meherubin&issn=1022-4742&title=Mymensingh+Medical+Journal%3A+MMJ&atitle=Relationship+between+Body+Mass+Index+and+Serum+Alanine+Transaminase+Concentration+in+Obese+Female.&volume=31&issue=3&spage=600&epage=605&date=2022&doi=&pmid=35780339&sid=OVID:medline
+
+<469>
+Unique Identifier
+ 35770372
+Title
+ Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort.
+Source
+ Andrology. 10(7):1328-1338, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Anand-Ivell R; Heng K; Severn K; Antonio L; Bartfai G; Casanueva FF; Huhtaniemi IT; Giwercman A; Maggi M; O'Neill TW; Punab M; Rastrelli G; Slowikowska-Hilczer J; Tournoy J; Vanderschueren D; Wu FCW; Ivell R
+Author NameID
+ Antonio, Leen; ORCID: https://orcid.org/0000-0002-1079-2860
+ Giwercman, Aleksander; ORCID: https://orcid.org/0000-0001-5816-0785
+ Ivell, Richard; ORCID: https://orcid.org/0000-0001-6513-2109
+Authors Full Name
+ Anand-Ivell, Ravinder; Heng, Kee; Severn, Katie; Antonio, Leen; Bartfai, Gyorgy; Casanueva, Felipe F; Huhtaniemi, Ilpo T; Giwercman, Aleksander; Maggi, Mario; O'Neill, Terence W; Punab, Margus; Rastrelli, Giulia; Slowikowska-Hilczer, Jolanta; Tournoy, Jos; Vanderschueren, Dirk; Wu, Frederick C W; Ivell, Richard.
+Institution
+ Anand-Ivell, Ravinder. School of Biosciences, University of Nottingham, University Park, Nottingham, UK.
+ Heng, Kee. School of Biosciences, University of Nottingham, University Park, Nottingham, UK.
+ Severn, Katie. School of Mathematics, University of Nottingham, University Park, Nottingham, UK.
+ Antonio, Leen. Department of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Belgium.
+ Antonio, Leen. Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.
+ Bartfai, Gyorgy. Department of Obstetrics, Gynaecology and Andrology, Albert Szent-Gyorgy Medical University, Szeged, Hungary.
+ Casanueva, Felipe F. Department of Medicine, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS), CIBER de Fisiopatologia Obesidad y Nutricion (CB06/03), Instituto Salud Carlos III, Santiago de Compostela, Spain.
+ Huhtaniemi, Ilpo T. Institute of Reproductive and Developmental, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
+ Giwercman, Aleksander. Department of Translational Medicine, Lund University, Malmo, Sweden.
+ Maggi, Mario. Endocrinology Unit, "Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
+ O'Neill, Terence W. Centre for Epidemiology Versus Arthritis, The University of Manchester & NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK.
+ Punab, Margus. Andrology Unit, United Laboratories of Tartu University Clinics, Tartu, Estonia.
+ Rastrelli, Giulia. Endocrinology Unit, "Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
+ Slowikowska-Hilczer, Jolanta. Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland.
+ Tournoy, Jos. Department of Geriatrics, University Hospitals Leuven, Leuven, Belgium.
+ Vanderschueren, Dirk. Department of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Belgium.
+ Vanderschueren, Dirk. Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.
+ Wu, Frederick C W. Department of Endocrinology, Manchester University NHS Foundation Trust, Manchester, UK.
+ Ivell, Richard. School of Biosciences, University of Nottingham, University Park, Nottingham, UK.
+MeSH Subject Headings
+ Adult
+ Aging/ph [Physiology]
+ Biomarkers/me [Metabolism]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Follicle Stimulating Hormone
+ Humans
+ Insulin/me [Metabolism]
+ Leydig Cells/me [Metabolism]
+ *Leydig Cells
+ Life Style
+ Luteinizing Hormone
+ Male
+ Obesity/me [Metabolism]
+ Proteins/me [Metabolism]
+ Sex Hormone-Binding Globulin/me [Metabolism]
+ Testosterone/me [Metabolism]
+Keyword Heading
+ HPG axis
+ INSL3
+ Leydig cell
+ aging male
+ hypogonadism
+ testosterone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Aging in men is accompanied by a broad range of symptoms, including sexual dysfunction, cognitive and musculoskeletal decline, obesity, type 2 diabetes, cardiovascular disease and hypertension, organ degeneration/failure, and increasing neoplasia, some of which are associated with declining levels of Leydig cell-produced testosterone. High natural biological variance, together with multiple factors that can modulate circulating testosterone concentration, may influence its interpretation and clinical implications. Insulin-like peptide 3 is a biomarker of Leydig cell function that might provide complementary information on testicular health and its downstream outcomes.
+
+ OBJECTIVES: To characterize insulin-like peptide 3 as a biomarker to assess gonadal status in aging men.
+
+ METHODS AND MATERIALS: A large European multicenter (European Male Aging Study) cohort of community-dwelling men was analyzed to determine how insulin-like peptide 3 relates to a range of hormonal, anthropometric, and lifestyle parameters.
+
+ RESULTS AND DISCUSSION: Insulin-like peptide 3 declines cross-sectionally and longitudinally within individuals at approximately 15% per decade from age 40 years, unlike testosterone (1.9% per decade), which is partly compensated by increasing pituitary luteinizing hormone production. Importantly, lower insulin-like peptide 3 in younger men appears to persist with aging. Multiple regression analysis shows that, unlike testosterone, insulin-like peptide 3 is negatively dependent on luteinizing hormone and sex hormone-binding globulin and positively dependent on follicle-stimulating hormone, suggesting a different mechanism of gonadotropic regulation. Circulating insulin-like peptide 3 is negatively associated with increased body mass index or waist circumference and with smoking, and unlike testosterone, it is not affected by weight loss in obese individuals. Geographic variation in mean insulin-like peptide 3 within Europe appears to be largely explained by differences in these parameters. The results allowed the establishment of a European-wide reference range for insulin-like peptide 3 (95% confidence interval) adjusted for increasing age.
+
+ CONCLUSION: Insulin-like peptide 3 is a constitutive biomarker of Leydig cell functional capacity and is a robust, reliably measurable peptide not subject to gonadotropin-dependent short-term regulation and within-individual variation in testosterone. Copyright © 2022 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 0 (Proteins). 0 (Sex Hormone-Binding Globulin). 3XMK78S47O (Testosterone). 9002-67-9 (Luteinizing Hormone). 9002-68-0 (Follicle Stimulating Hormone).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2fandr.13220
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Anand-Ivell&issn=2047-2919&title=Andrology&atitle=Association+of+age%2C+hormonal%2C+and+lifestyle+factors+with+the+Leydig+cell+biomarker+INSL3+in+aging+men+from+the+European+Male+Aging+Study+cohort.&volume=10&issue=7&spage=1328&epage=1338&date=2022&doi=10.1111%2Fandr.13220&pmid=35770372&sid=OVID:medline
+
+<470>
+Unique Identifier
+ 35741707
+Title
+ Association between SNPs in Leptin Pathway Genes and Anthropometric, Biochemical, and Dietary Markers Related to Obesity.
+Source
+ Genes (Basel). 13(6), 2022 05 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cadena-Lopez RO; Hernandez-Rodriguez LV; Aguilar-Galarza A; Garcia-Munoz W; Haddad-Talancon L; Anzures-Cortes ML; Velazquez-Sanchez C; Flores-Viveros KL; Anaya-Loyola MA; Garcia-Gasca T; Rodriguez-Garcia VM; Moreno-Celis U
+Author NameID
+ Hernandez-Rodriguez, Lourdes Vanessa; ORCID: https://orcid.org/0000-0001-9647-8401
+ Anaya-Loyola, Miriam Aracely; ORCID: https://orcid.org/0000-0002-9959-3621
+ Rodriguez-Garcia, Victor Manuel; ORCID: https://orcid.org/0000-0003-0243-6476
+ Moreno-Celis, Ulisses; ORCID: https://orcid.org/0000-0003-3751-6601
+Authors Full Name
+ Cadena-Lopez, Ricardo Omar; Hernandez-Rodriguez, Lourdes Vanessa; Aguilar-Galarza, Adriana; Garcia-Munoz, Willebaldo; Haddad-Talancon, Lorenza; Anzures-Cortes, Ma de Lourdes; Velazquez-Sanchez, Claudia; Flores-Viveros, Karla Lucero; Anaya-Loyola, Miriam Aracely; Garcia-Gasca, Teresa; Rodriguez-Garcia, Victor Manuel; Moreno-Celis, Ulisses.
+Institution
+ Cadena-Lopez, Ricardo Omar. Ingenieria en Biotecnologia, Facultad de Quimica, Universidad Autonoma de Queretaro, Queretaro 76010, Mexico.
+ Hernandez-Rodriguez, Lourdes Vanessa. Medico Cirujano, Centro de Ciencias de la Salud, Universidad Autonoma de Aguascalientes. Av. Universidad #940, Ciudad Universitaria, Aguascalientes 20100, Mexico.
+ Aguilar-Galarza, Adriana. Servicio Universitario de Salud, Secretaria de Atencion a la Comunidad Universitaria, Universidad Autonoma de Queretaro, Las Campanas, Queretaro 76010, Mexico.
+ Garcia-Munoz, Willebaldo. Laboratorio de Genetica Humana, Codigo 46, S.A. de C.V., Cuernavaca 62498, Mexico.
+ Haddad-Talancon, Lorenza. Laboratorio de Genetica Humana, Codigo 46, S.A. de C.V., Cuernavaca 62498, Mexico.
+ Anzures-Cortes, Ma de Lourdes. Laboratorio de Genetica Humana, Codigo 46, S.A. de C.V., Cuernavaca 62498, Mexico.
+ Velazquez-Sanchez, Claudia. Laboratorio de Genetica Humana, Codigo 46, S.A. de C.V., Cuernavaca 62498, Mexico.
+ Flores-Viveros, Karla Lucero. Facultad de Enfermeria, Universidad Autonoma de Queretaro, Las Campanas, Queretaro 76010, Mexico.
+ Anaya-Loyola, Miriam Aracely. Facultad de Ciencias Naturales, Universidad Autonoma de Queretaro, Juriquilla, Queretaro 76230, Mexico.
+ Garcia-Gasca, Teresa. Facultad de Ciencias Naturales, Universidad Autonoma de Queretaro, Juriquilla, Queretaro 76230, Mexico.
+ Rodriguez-Garcia, Victor Manuel. Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, San Pablo, Queretaro 76130, Mexico.
+ Moreno-Celis, Ulisses. Facultad de Ciencias Naturales, Universidad Autonoma de Queretaro, Juriquilla, Queretaro 76230, Mexico.
+MeSH Subject Headings
+ Biomarkers
+ Cholesterol
+ *Diabetes Mellitus, Type 2
+ Diet
+ Female
+ Humans
+ Insulins/ge [Genetics]
+ *Insulins
+ Leptin/ge [Genetics]
+ Male
+ Obesity/ep [Epidemiology]
+ Polymorphism, Single Nucleotide
+ Pro-Opiomelanocortin/ge [Genetics]
+ Young Adult
+Keyword Heading
+ leptin pathway
+ obesity
+ single nucleotide polymorphism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is one of the main public health problems in Mexico and the world and one from which a large number of pathologies derive. Single nucleotide polymorphisms (SNPs) of various genes have been studied and proven to contribute to the development of multiple diseases. SNPs of the leptin pathway have been associated with the control of hunger and energy expenditure as well as with obesity and type 2 diabetes mellitus. Therefore, the present work focused on determining the association between anthropometric markers and biochemical and dietary factors related to obesity and SNPs of leptin pathway genes, such as the leptin gene (LEP), the leptin receptor (LEPR), proopiomelanocortin (POMC), prohormone convertase 1 (PCSK1), and the melanocortin 4 receptor (MC4R). A population of 574 young Mexican adults of both sexes, aged 19 years old on average and without metabolic disorders previously diagnosed, underwent a complete medical and nutritional evaluation, biochemical determination, and DNA extraction from the blood; DNA samples were subsequently genotyped. Association analyses between anthropometric, biochemical, and dietary variables with SNPs were performed using binary logistic regressions (p-value = 0.05). Although the sampled population did not have previously diagnosed diseases, the evaluation results showed that 33% were overweight or obese according to BMI and 64% had non-clinically elevated levels of body fat. From the 74 SNP markers analyzed from the five previously mentioned genes, 62 showed polymorphisms within the sampled population, and only 35 of these had significant associations with clinical variables. The risk associations (OR > 1) occurred between clinical markers with elevated values for waist circumference, waist-height index, BMI, body fat percentage, glucose levels, insulin levels, HOMA-IR, triglyceride levels, cholesterol levels, LDL-c, low HDL-c, carbohydrate intake, and protein intake and SNPs of the LEP, LEPR, PCSK1, and MC4R genes. On the other hand, the protective associations (OR < 1) were associated with markers including elevated values for insulin, HOMA-IR, cholesterol, c-LDL, energy intake > 2440 Kcal/day, and lipid intake and SNPs of the LEP and LEPR genes and POMC. The present study describes associations between SNPs in leptin pathway genes, revealing positive and negative interactions between reported SNPs and the clinical markers related to obesity in a sampled Mexican population. Hence, our results open the door for the further study of new genetic variants and their influence on obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulins). 0 (Leptin). 66796-54-1 (Pro-Opiomelanocortin). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fgenes13060945
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cadena-Lopez&issn=2073-4425&title=Genes+%28Basel%29&atitle=Association+between+SNPs+in+Leptin+Pathway+Genes+and+Anthropometric%2C+Biochemical%2C+and+Dietary+Markers+Related+to+Obesity.&volume=13&issue=6&spage=&epage=&date=2022&doi=10.3390%2Fgenes13060945&pmid=35741707&sid=OVID:medline
+
+<471>
+Unique Identifier
+ 35739407
+Title
+ Hybrid and Remote Psychosocial Interventions Focused on Weight and Sedentary Behavior Management Among Patients with Severe Mental Illnesses: a Systematic Review. [Review]
+Source
+ Psychiatric Quarterly. 93(3):813-840, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Oliveira ACN; Guariente SMM; Zazula R; Mesas AE; Oliveira CEC; Reiche EMV; Nunes SOV
+Author NameID
+ Zazula, Robson; ORCID: https://orcid.org/0000-0001-8473-050X
+Authors Full Name
+ Oliveira, Ana Cecilia Novaes; Guariente, Suzana Maria Menezes; Zazula, Robson; Mesas, Arthur Eumann; Oliveira, Carlos Eduardo Coral; Reiche, Edna Maria Vissosi; Nunes, Sandra Odebrecht Vargas.
+Institution
+ Oliveira, Ana Cecilia Novaes. Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Parana, Brazil.
+ Guariente, Suzana Maria Menezes. Department of Clinical Medicine, Health Sciences Center, Psychiatry Unit, State University of Londrina, Parana, Brazil.
+ Zazula, Robson. School of Medicine, Federal University of Latin American Integration, Foz do Iguacu, Parana, 85870-901, Brazil. robsonzazula@gmail.com.
+ Mesas, Arthur Eumann. Universidad de Castilla-La Mancha, Cuenca, Spain.
+ Oliveira, Carlos Eduardo Coral. Pontifical Catholic University of Parana (PUC), Londrina, Brazil.
+ Reiche, Edna Maria Vissosi. Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Parana, Brazil.
+ Nunes, Sandra Odebrecht Vargas. Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Parana, Brazil.
+MeSH Subject Headings
+ Biomarkers
+ Humans
+ Mental Disorders/th [Therapy]
+ *Mental Disorders
+ Obesity
+ Psychosocial Intervention
+ *Sedentary Behavior
+Keyword Heading
+ Digital intervention
+ Psychosocial intervention
+ Sedentary behavior
+ Severe mental illness
+ Systematic review
+ Weight loss
+ e-health
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Severe mental illness could be defined through its diagnosis, disability, and duration, and one of their main characteristics is the high prevalence of some clinical conditions such as obesity and metabolic syndrome. Although the promotion of a healthier lifestyle has been demonstrated as an effective strategy to reduce both body mass index and abdominal circumference in this population, there is a lack of studies focusing on digital intervention in this population. The aim of this systematic review was to evaluate the efficacy of studies that used digital technologies to reduce weight, body mass index (BMI) and abdominal circumference in individuals with severe mental illness. This current review also compared remote and hybrid interventions, the effects of those interventions in metabolic biomarkers as well as in the development of a healthier lifestyle. The main findings included the following: (a) the use of digital devices or strategies might be feasible and useful to reduce sedentary behavior among individuals with severe mental illnesses, 2) most interventions used digital pedometers and mobile phone communication (either text messages or phone calls) as main strategies, 3) all remote interventions and six of nine hybrid interventions found significant outcomes in favor of their interventions. In conclusion, even with a limited number of studies promoting healthier lifestyle through digital interventions among individuals with severe mental illnesses, evidence from studies included in this review showed that they might be useful to improve a healthier lifestyle and increase the frequency of physical activity behavior. Copyright © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs11126-022-09994-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Oliveira&issn=0033-2720&title=Psychiatric+Quarterly&atitle=Hybrid+and+Remote+Psychosocial+Interventions+Focused+on+Weight+and+Sedentary+Behavior+Management+Among+Patients+with+Severe+Mental+Illnesses%3A+a+Systematic+Review.&volume=93&issue=3&spage=813&epage=840&date=2022&doi=10.1007%2Fs11126-022-09994-3&pmid=35739407&sid=OVID:medline
+
+<472>
+Unique Identifier
+ 35728124
+Title
+ Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity.
+Source
+ Diabetes/Metabolism Research Reviews. 38(7):e3559, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Di Bonito P; Valerio G; Licenziati MR; Di Sessa A; Miraglia Del Giudice E; Morandi A; Maffeis C; Baroni MG; Chiesa C; Pacifico L; Manco M
+Author NameID
+ Valerio, Giuliana; ORCID: https://orcid.org/0000-0001-5063-4333
+ Manco, Melania; ORCID: https://orcid.org/0000-0002-6581-975X
+Authors Full Name
+ Di Bonito, Procolo; Valerio, Giuliana; Licenziati, Maria Rosaria; Di Sessa, Anna; Miraglia Del Giudice, Emanuele; Morandi, Anita; Maffeis, Claudio; Baroni, Marco Giorgio; Chiesa, Claudio; Pacifico, Lucia; Manco, Melania.
+Institution
+ Di Bonito, Procolo. Department of Internal Medicine, "S. Maria delle Grazie" Hospital, Pozzuoli, Italy.
+ Valerio, Giuliana. Department of Movement Sciences and Wellbeing, University "Parthenope", Naples, Italy.
+ Licenziati, Maria Rosaria. Department of Neuroscience, Obesity and Endocrine Disease Unit, Santobono-Pausilipon Children's Hospital, Naples, Italy.
+ Di Sessa, Anna. Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Miraglia Del Giudice, Emanuele. Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Morandi, Anita. Pediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy.
+ Maffeis, Claudio. Pediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy.
+ Baroni, Marco Giorgio. Department of Clinical Medicine, Life, Health & Environmental Sciences, University of L'Aquila, Italy.
+ Baroni, Marco Giorgio. Neuroendocrinology and Metabolic Diseases, IRCCS Neuromed, Pozzilli, Italy.
+ Chiesa, Claudio. Institute of Translational Pharmacology, National Research Council, Rome, Italy.
+ Pacifico, Lucia. Department of Pediatrics, Policlinico Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
+ Manco, Melania. Research Area for Multifactorial Disease and Complex Phenotypes, Children's Hospital Bambino Gesu, IRCCS, Rome, Italy.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ Child
+ Child, Preschool
+ Cross-Sectional Studies
+ Glucose
+ Humans
+ Lipoproteins, HDL
+ *Liver Diseases
+ Longitudinal Studies
+ *Metabolic Syndrome
+ Obesity/ep [Epidemiology]
+ Overweight/co [Complications]
+ Prevalence
+ Risk Factors
+ Triglycerides
+ Uric Acid
+Keyword Heading
+ children
+ fructose
+ metabolic syndrome score
+ non-alcoholic fatty liver disease
+ obesity
+ uric acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: To compare the association of high serum uric acid (HUA) or metabolic syndrome (MetS) with fatty liver disease (FLD) in youths with overweight/obesity (OW/OB).
+
+ MATERIALS AND METHODS: Cross-sectional study of anthropometrics, biochemical variables, and liver ultrasound of 3104 individuals with OW/OB (age 5-17 years). Metabolic syndrome was defined by >= 3 criteria among (1) high waist circumference; (2) high triglycerides; (3) low high-density lipoproteins; (4) fasting glucose >=100 mg/dl; (5) blood pressure >=95th percentile in children, and >=130/80 mmHg in adolescents. High serum uric acid was defined as serum UA value >= 75th percentile adjusted for sex. Fatty liver disease was determined by echography.
+
+ RESULTS: The sample was stratified in four categories: (1) no HUA, no MetS (reference category); (2) MetS; (3) HUA; (4) HUA and MetS (HUA + MetS). The prevalence of FLD increased across the four categories from 29.9%, 44.0%, 52.2%, to 67.1%, respectively (p < 0.0001). The ORs for the categorical variables were 1.33 (1.06-1.68) for MetS (p = 0.02), 3.19 (2.51-4.05) for HUA (p < 0.0001) and 3.72 (2.65-5.21) for HUA + MetS (p < 0.0001), versus the reference category regardless of the body mass index.
+
+ CONCLUSIONS: HUA represents a useful marker of FLD in youths with OW/OB, given its greater ability to identify those at increased risk of the disease compared to MetS. The ability of both to predict incident FLD must be investigated in longitudinal study. Copyright © 2022 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipoproteins, HDL). 0 (Triglycerides). 268B43MJ25 (Uric Acid). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1002%2fdmrr.3559
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Di+Bonito&issn=1520-7552&title=Diabetes%2FMetabolism+Research+Reviews&atitle=Uric+acid+versus+metabolic+syndrome+as+markers+of+fatty+liver+disease+in+young+people+with+overweight%2Fobesity.&volume=38&issue=7&spage=e3559&epage=&date=2022&doi=10.1002%2Fdmrr.3559&pmid=35728124&sid=OVID:medline
+
+<473>
+Unique Identifier
+ 35704337
+Title
+ Dissecting the relationship between plasma and tissue metabolome in a cohort of women with obesity: Analysis of subcutaneous and visceral adipose, muscle, and liver.
+Source
+ FASEB Journal. 36(7):e22371, 2022 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu ZE; Kruger MC; Cooper GJS; Sequeira IR; McGill AT; Poppitt SD; Fraser K
+Author NameID
+ Wu, Zhanxuan E; ORCID: https://orcid.org/0000-0003-1896-0221
+Authors Full Name
+ Wu, Zhanxuan E; Kruger, Marlena C; Cooper, Garth J S; Sequeira, Ivana R; McGill, Anne-Thea; Poppitt, Sally D; Fraser, Karl.
+Institution
+ Wu, Zhanxuan E. Food Chemistry and Structure, AgResearch Limited, Palmerston North, New Zealand.
+ Wu, Zhanxuan E. School of Health Sciences, Massey University, Palmerston North, New Zealand.
+ Wu, Zhanxuan E. High-Value Nutrition National Science Challenge, Auckland, New Zealand.
+ Kruger, Marlena C. School of Health Sciences, Massey University, Palmerston North, New Zealand.
+ Kruger, Marlena C. Riddet Institute, Massey University, Palmerston North, New Zealand.
+ Cooper, Garth J S. School of Biological Sciences, University of Auckland, Auckland, New Zealand.
+ Cooper, Garth J S. Department of Medicine, University of Auckland, Auckland, New Zealand.
+ Cooper, Garth J S. Centre for Advanced Discovery and Experimental Therapeutics, School of Medical Sciences, University of Manchester, Manchester, UK.
+ Sequeira, Ivana R. High-Value Nutrition National Science Challenge, Auckland, New Zealand.
+ Sequeira, Ivana R. School of Biological Sciences, University of Auckland, Auckland, New Zealand.
+ Sequeira, Ivana R. Human Nutrition Unit, School of Biological Sciences, University of Auckland, Auckland, New Zealand.
+ McGill, Anne-Thea. Human Nutrition Unit, School of Biological Sciences, University of Auckland, Auckland, New Zealand.
+ Poppitt, Sally D. High-Value Nutrition National Science Challenge, Auckland, New Zealand.
+ Poppitt, Sally D. Riddet Institute, Massey University, Palmerston North, New Zealand.
+ Poppitt, Sally D. Department of Medicine, University of Auckland, Auckland, New Zealand.
+ Poppitt, Sally D. Human Nutrition Unit, School of Biological Sciences, University of Auckland, Auckland, New Zealand.
+ Fraser, Karl. Food Chemistry and Structure, AgResearch Limited, Palmerston North, New Zealand.
+ Fraser, Karl. High-Value Nutrition National Science Challenge, Auckland, New Zealand.
+ Fraser, Karl. Riddet Institute, Massey University, Palmerston North, New Zealand.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Ethers/me [Metabolism]
+ Female
+ Humans
+ Liver/me [Metabolism]
+ *Metabolome
+ Metabolomics/mt [Methods]
+ Muscles/me [Metabolism]
+ Obesity/me [Metabolism]
+ Phosphatidylcholines/me [Metabolism]
+ Phosphatidylethanolamines/me [Metabolism]
+ *Phosphatidylethanolamines
+ Triglycerides/me [Metabolism]
+Keyword Heading
+ biomarkers
+ clinical metabolomics
+ liquid chromatography-mass spectrometry
+ tissue metabolomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Untargeted metabolomics of blood samples has become widely applied to study metabolic alterations underpinning disease and to identify biomarkers. However, understanding the relevance of a blood metabolite marker can be challenging if it is unknown whether it reflects the concentration in relevant tissues. To explore this field, metabolomic and lipidomic profiles of plasma, four sites of adipose tissues (ATs) from peripheral or central depot, two sites of muscle tissue, and liver tissue from a group of nondiabetic women with obesity who were scheduled to undergo bariatric surgery (n = 21) or other upper GI surgery (n = 5), were measured by liquid chromatography coupled with mass spectrometry. Relationships between plasma and tissue profiles were examined using Pearson correlation analysis subject to Benjamini-Hochberg correction. Plasma metabolites and lipids showed the highest number of significantly positive correlations with their corresponding concentrations in liver tissue, including lipid species of ceramide, mono- and di-hexosylceramide, sphingomyelin, phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylethanolamine, dimethyl phosphatidylethanolamine, ether-linked PC, ether-linked PE, free fatty acid, cholesteryl ester, diacylglycerol and triacylglycerol, and polar metabolites linked to several metabolic functions and gut microbial metabolism. Plasma also showed significantly positive correlations with muscle for several phospholipid species and polar metabolites linked to metabolic functions and gut microbial metabolism, and with AT for several triacylglycerol species. In conclusion, plasma metabolomic and lipidomic profiles were reflective more of the liver profile than any of the muscle or AT sites examined in the present study. Our findings highlighted the importance of taking into consideration the metabolomic relationship of various tissues with plasma when postulating plasma metabolites marker to underlying mechanisms occurring in a specific tissue. Copyright © 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ethers). 0 (Phosphatidylcholines). 0 (Phosphatidylethanolamines). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1096%2ffj.202101812R
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=0892-6638&title=FASEB+Journal&atitle=Dissecting+the+relationship+between+plasma+and+tissue+metabolome+in+a+cohort+of+women+with+obesity%3A+Analysis+of+subcutaneous+and+visceral+adipose%2C+muscle%2C+and+liver.&volume=36&issue=7&spage=e22371&epage=&date=2022&doi=10.1096%2Ffj.202101812R&pmid=35704337&sid=OVID:medline
+
+<474>
+Unique Identifier
+ 35700149
+Title
+ Avocado Consumption for 12 Weeks and Cardiometabolic Risk Factors: A Randomized Controlled Trial in Adults with Overweight or Obesity and Insulin Resistance.
+Source
+ Journal of Nutrition. 152(8):1851-1861, 2022 08 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang X; Xiao D; Guzman G; Edirisinghe I; Burton-Freeman B
+Author NameID
+ Zhang, Xuhuiqun; ORCID: https://orcid.org/0000-0001-8760-7080
+ Xiao, Di; ORCID: https://orcid.org/0000-0002-5916-6107
+ Edirisinghe, Indika; ORCID: https://orcid.org/0000-0003-2627-4176
+ Burton-Freeman, Britt; ORCID: https://orcid.org/0000-0002-3754-9852
+Authors Full Name
+ Zhang, Xuhuiqun; Xiao, Di; Guzman, Gabriela; Edirisinghe, Indika; Burton-Freeman, Britt.
+Institution
+ Zhang, Xuhuiqun. Department of Food Science and Nutrition, Center for Nutrition Research and Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.
+ Xiao, Di. Department of Food Science and Nutrition, Center for Nutrition Research and Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.
+ Guzman, Gabriela. Department of Food Science and Nutrition, Center for Nutrition Research and Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.
+ Edirisinghe, Indika. Department of Food Science and Nutrition, Center for Nutrition Research and Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.
+ Burton-Freeman, Britt. Department of Food Science and Nutrition, Center for Nutrition Research and Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Blood Glucose/me [Metabolism]
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Diet, Fat-Restricted
+ Dietary Fiber
+ Female
+ Humans
+ Insulin
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ Overweight/me [Metabolism]
+ Persea/me [Metabolism]
+ *Persea
+Keyword Heading
+ HbA1c
+ Matsuda Insulin Sensitivity Index
+ avocado
+ cardiovascular risk factors
+ insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Diets emphasizing unsaturated fat and high fiber are associated with reducing cardiometabolic risk factors. Avocados are rich in MUFA and PUFA fats and fiber.
+
+ OBJECTIVES: Assess replacement of carbohydrate energy with avocado energy for 12 wk on glucose homeostasis and cardiometabolic risk factors in self-selecting free-living adults who are overweight or with obesity and have insulin resistance.
+
+ METHODS: In a single-center, randomized, 2-arm, controlled, 12-wk parallel trial, adults [n = 93; male/female: 39/54; mean +/- SD age: 42 +/- 12 y; BMI: 32.6 +/- 3.9 (in kg/m2); HOMA-IR: 2.7 +/- 1.7] were counseled to exchange avocado (AV) or control food (C; low fat, low fiber, energy matched) for carbohydrate food in their usual diet for 12 wk. The primary outcome was the change in Matsuda Insulin Sensitivity Index (MISI) after 12-wk interventions. Secondary outcomes were changes in fasting and post-oral glucose tolerance test glycemic variables, fasting lipids, endothelial activation and inflammation markers. Automated Self-Administered 24-h Dietary Assessment Tool captured weekly dietary intake. Intervention effects were mainly determined by ANCOVA using PC-SAS version 9.4.
+
+ RESULTS: Dietary total, MUFA, and PUFA fat; fiber; and vegetable intake were higher in the AV group compared with the C group (P < 0.05), and no change in body weight or composition was observed (P > 0.05). Differences between the changes in MISI after AV compared with C were not different (DELTA0-12 wk, P = 0.1092). Differences in fasting insulin (DELTA0-12 wk, P = 0.0855) and improved glycated hemoglobin (DELTA0-12 wk, P = 0.0632) after AV compared with C were suggested. C-reactive protein was significantly lower after AV compared with C at 12 wk (P = 0.0418). Select biomarkers of endothelial activation and lipoproteins by NMR were also influenced by AV compared with C food intake.
+
+ CONCLUSIONS: Avocado intake was associated with a healthier dietary pattern and trends favoring improved glucose control and reduced biomarkers of cardiometabolic risk when replacing avocado energy for carbohydrate energy in free-living adults who are overweight or with obesity and have insulin resistance. This trial was registered at clinicaltrials.gov as NCT02695433. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Fiber). 0 (Insulin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1093%2fjn%2fnxac126
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=0022-3166&title=Journal+of+Nutrition&atitle=Avocado+Consumption+for+12+Weeks+and+Cardiometabolic+Risk+Factors%3A+A+Randomized+Controlled+Trial+in+Adults+with+Overweight+or+Obesity+and+Insulin+Resistance.&volume=152&issue=8&spage=1851&epage=1861&date=2022&doi=10.1093%2Fjn%2Fnxac126&pmid=35700149&sid=OVID:medline
+
+<475>
+Unique Identifier
+ 35687086
+Title
+ Association of microalbuminuria with serum lipids and inflammatory markers in an adult population in the Dikgale Health and Demographic Surveillance System site, South Africa.
+Source
+ Cardiovascular Journal of Africa. 33(5):234-242, 2022 Sep-Oct 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Magwai T; Modjadji P; Choma S
+Authors Full Name
+ Magwai, Thabo; Modjadji, Perpetua; Choma, Solomon.
+Institution
+ Magwai, Thabo. Department of Pathology and Medical Sciences, School of Health Care Sciences, Faculty of Health Sciences, University of Limpopo, South Africa. Email: thabo.magwai9096@outlook.com.
+ Modjadji, Perpetua. Department of Pathology and Medical Sciences, School of Health Care Sciences, Faculty of Health Sciences, University of Limpopo, South Africa; Department of Public Health, School of Health Care Sciences, Sefako Makgatho Health Sciences University, South Africa.
+ Choma, Solomon. Department of Pathology and Medical Sciences, School of Health Care Sciences, Faculty of Health Sciences, University of Limpopo, South Africa.
+MeSH Subject Headings
+ Adult
+ Male
+ Female
+ Humans
+ Middle Aged
+ Aged
+ *Insulin Resistance
+ C-Reactive Protein
+ Creatinine/ur [Urine]
+ Overweight/co [Complications]
+ South Africa/ep [Epidemiology]
+ Albuminuria/di [Diagnosis]
+ Albuminuria/ep [Epidemiology]
+ Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ *Hypertension
+ Biomarkers
+ Triglycerides
+ Risk Factors
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Cholesterol
+ Glucose
+Keyword Heading
+ South Africa
+ inflammatory markers
+ microalbuminuria
+ rural HDSS site
+ serum lipids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: There is evidence that microalbuminuria (urinary albumin excretion) is an early sign of vascular damage and an established risk factor for cardiovascular morbidity and mortality. This study investigated the magnitude of microalbuminuria and its association with serum lipids and inflammatory markers among a rural black population residing in the Dikgale Health and Demographic Surveillance System site, South Africa.
+
+ METHODS: Data were collected from 602 presumably healthy participants (225 men and 377 women) aged >= 18 years. Biochemical data collection included serum lipids, glucose, insulin, high-sensitivity C-reactive protein (hs-CRP), urine albumin and creatinine. Anthropometry and blood pressure were also measured. Microalbuminuria was diagnosed with an albumin-creatinine ratio of >= 2.5 mg/mmol in men and >= 3.5 mg/mmol in women. Data were analysed using SPSS version 22.0.
+
+ RESULTS: The mean age of participants was 48.63 +/- 20.89 years. High percentages of microalbuminaria (35.7%), high levels of interleukin 6 (17.8%), hs-CRP (32.9%), triglycerides (TG) (26.1%), low-density lipoprotein cholesterol (52.2%) and total cholesterol (32.0%), and low levels of high-density lipoprotein cholesterol (29.1%) were observed in the population. Increased glucose levels (32.8%), insulin resistance (27.6%), hypertension (45.8%), overweight (26.8%) and obesity (25.4%) were also prevalent. Microalbuminuria was associated with high hs-CRP and TG levels in the men (adjusted odds ratios = 9.434, 95% confidence interval: 1.753 - 50.778, p = 0.01).
+
+ CONCLUSIONS: High prevalence of microalbuminuria, hypertension, insulin resistance, overweight and obesity, as well as abnormal levels of serum lipids and inflammatory markers were observed in the population. Microalbuminuria was associated with high hs-CRP and TG levels among men.
+Registry Number/Name of Substance
+ 9007-41-4 (C-Reactive Protein). AYI8EX34EU (Creatinine). 0 (Biomarkers). 0 (Triglycerides). 97C5T2UQ7J (Cholesterol). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.5830%2fCVJA-2021-055
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Magwai&issn=1015-9657&title=Cardiovascular+Journal+of+Africa&atitle=Association+of+microalbuminuria+with+serum+lipids+and+inflammatory+markers+in+an+adult+population+in+the+Dikgale+Health+and+Demographic+Surveillance+System+site%2C+South+Africa.&volume=33&issue=5&spage=234&epage=242&date=2022&doi=10.5830%2FCVJA-2021-055&pmid=35687086&sid=OVID:medline
+
+<476>
+Unique Identifier
+ 35685490
+Title
+ Circulating Inflammatory Markers May Mediate the Relationship between Healthy Plant-Based Diet and Metabolic Phenotype Obesity in Women: A Cross-Sectional Study.
+Source
+ International Journal of Clinical Practice. 2022:8099382, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mohamadi A; Shiraseb F; Mirzababaei A; Hosseininasab D; Rasaei N; Clark CCT; Mirzaei K
+Author NameID
+ Mohamadi, Azam; ORCID: https://orcid.org/0000-0001-7442-6280
+ Shiraseb, Farideh; ORCID: https://orcid.org/0000-0001-9279-5063
+ Mirzababaei, Atieh; ORCID: https://orcid.org/0000-0002-1540-4716
+ Hosseininasab, Dorsa; ORCID: https://orcid.org/0000-0003-1614-137X
+ Rasaei, Niloufar; ORCID: https://orcid.org/0000-0002-4997-0556
+ Clark, Cain C T; ORCID: https://orcid.org/0000-0002-6610-4617
+ Mirzaei, Khadijeh; ORCID: https://orcid.org/0000-0003-0231-0478
+Authors Full Name
+ Mohamadi, Azam; Shiraseb, Farideh; Mirzababaei, Atieh; Hosseininasab, Dorsa; Rasaei, Niloufar; Clark, Cain C T; Mirzaei, Khadijeh.
+Institution
+ Mohamadi, Azam. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Shiraseb, Farideh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Mirzababaei, Atieh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Hosseininasab, Dorsa. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
+ Rasaei, Niloufar. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Clark, Cain C T. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, UK.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Cross-Sectional Studies
+ Diet, Vegetarian
+ Female
+ Humans
+ Iran
+ Obesity/me [Metabolism]
+ *Overweight
+ Phenotype
+ *Transforming Growth Factor beta1
+Abstract
+ Background: It has been posited that both metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO) could be emergent from diet and inflammatory markers. Thus, we sought to investigate the influence of plant-based diet on MHO and MUHO phenotypes mediated by inflammatory markers in overweight and obese women.
+
+ Methods: This cross-sectional study was conducted on 289 women aged >=18 years, with a body mass index (BMI) >=25 kg/m2. Dietary intake was measured using 147 item food frequency questionnaire, as well as anthropometrics and biochemistry panel, in all participants. Metabolic health phenotypes were considered using Karelis score, while plant-based diet indices (PDI) were evaluated based on 18 food groups, where healthy and unhealthy PDI were identified.
+
+ Results: Accordingly, 26.9% of women had MHO and 73.1% had MUHO phenotypes. After adjusting for potential confounders, TGF-beta1 had a significant inverse association with hPDI (beta: -0.28; 95% CI: 452.99, -85.25; P: 0.004). Moreover, we found that women with higher hPDI had lower odds of MUHO (OR: 0.95; 95% CI: 0.39, 2.30; P: 0.03). Regarding the mediatory effect of the inflammatory markers, TGF-beta1 (P: 0.73), IL-beta1 (P: 0.14), and MCP1 (P: 0.51) played a role in decreasing the odds of MUHO among hPDI tertiles.
+
+ Conclusion: There was a significant inverse relationship between adherence to hPDI and MUHO phenotype in overweight and obese Iranian women. This association appeared to be mediated by TGF-beta1, IL-beta1, and MCP1. Copyright © 2022 Azam Mohamadi et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Transforming Growth Factor beta1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1155%2f2022%2f8099382
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mohamadi&issn=1368-5031&title=International+Journal+of+Clinical+Practice&atitle=Circulating+Inflammatory+Markers+May+Mediate+the+Relationship+between+Healthy+Plant-Based+Diet+and+Metabolic+Phenotype+Obesity+in+Women%3A+A+Cross-Sectional+Study.&volume=2022&issue=&spage=8099382&epage=&date=2022&doi=10.1155%2F2022%2F8099382&pmid=35685490&sid=OVID:medline
+
+<477>
+Unique Identifier
+ 35679338
+Title
+ Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population.
+Source
+ PLoS ONE [Electronic Resource]. 17(6):e0265362, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cobos-Palacios L; Ruiz-Moreno MI; Vilches-Perez A; Vargas-Candela A; Munoz-Ubeda M; Benitez Porres J; Navarro-Sanz A; Lopez-Carmona MD; Sanz-Canovas J; Perez-Belmonte LM; Mancebo-Sevilla JJ; Gomez-Huelgas R; Bernal-Lopez MR
+Author NameID
+ Benitez Porres, Javier; ORCID: https://orcid.org/0000-0001-7546-7965
+ Sanz-Canovas, Jaime; ORCID: https://orcid.org/0000-0003-3722-5492
+ Bernal-Lopez, Maria Rosa; ORCID: https://orcid.org/0000-0002-0238-0890
+Authors Full Name
+ Cobos-Palacios, Lidia; Ruiz-Moreno, Maria Isabel; Vilches-Perez, Alberto; Vargas-Candela, Antonio; Munoz-Ubeda, Monica; Benitez Porres, Javier; Navarro-Sanz, Ana; Lopez-Carmona, Maria Dolores; Sanz-Canovas, Jaime; Perez-Belmonte, Luis M; Mancebo-Sevilla, Juan Jose; Gomez-Huelgas, Ricardo; Bernal-Lopez, Maria Rosa.
+Institution
+ Cobos-Palacios, Lidia. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Ruiz-Moreno, Maria Isabel. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Vilches-Perez, Alberto. Department of Endocrinology and Nutrition, Instituto de Investigacion Biomedica de Malaga (IBIMA), University Hospital Virgen de la Victoria, Malaga, Spain.
+ Vargas-Candela, Antonio. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Munoz-Ubeda, Monica. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Benitez Porres, Javier. Physical Education and Sports Area, Faculty of Medicine, University of Malaga, Malaga, Spain.
+ Navarro-Sanz, Ana. Sports Area, Sport Medicine, Malaga City Hall, Malaga, Spain.
+ Lopez-Carmona, Maria Dolores. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Sanz-Canovas, Jaime. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Perez-Belmonte, Luis M. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Mancebo-Sevilla, Juan Jose. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Gomez-Huelgas, Ricardo. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Gomez-Huelgas, Ricardo. CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain.
+ Bernal-Lopez, Maria Rosa. Department of Internal Medicine, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, University of Malaga, Malaga, Spain.
+ Bernal-Lopez, Maria Rosa. CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain.
+MeSH Subject Headings
+ Adipokines
+ Adiponectin
+ Aged
+ Aged, 80 and over
+ Biomarkers
+ C-Reactive Protein/me [Metabolism]
+ Female
+ Humans
+ *Insulins
+ Interleukin-6
+ Male
+ Obesity/ep [Epidemiology]
+ *Obesity, Metabolically Benign
+ Resistin
+ Triglycerides
+ Tumor Necrosis Factor-alpha
+Abstract
+ BACKGROUND AND AIMS: Obesity is linked to elevated levels of inflammatory serum markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNFa). Adiponectin and resistin are adipokines related to obesity. It has been described that adipose tissue presents a high production and secretion of these diverse pro-inflammatory molecules, which may have local effects on the physiology of fat cells as well as systemic effects on other organs. Our aim was to evaluate the impact that lifestyle modifications, by following a Mediterranean Diet (MedDiet) program and physical activity (PA) training, would have on inflammatory biomarkers and adipokine profile in a Metabolically Healthy Obese (MHO) elderly population from Malaga (Andalusia, Spain).
+
+ SUBJETCS AND METHODS: Subjects aged >=65 years (65 to 87 years old) with obesity (BMI >=30 kg/m2) were included in this study if they met <=1 of the following criteria: systolic blood pressure >=130 mmHg and/or diastolic blood pressure >= 85 mmHg; triglycerides >=150 mg/dL; HDL-C <40mg/dL in men and <50mg/dL women; and fasting blood glucose >=100mg/dL. Selected subjects underwent a personalized intensive lifestyle modification. Anthropometric measurements, PA, MedDiet adherence, analytical parameters, and inflammatory biomarkers were analyzed after 12 months of intervention.
+
+ RESULTS: 166 MHO elderly subjects, 40 (24.1%) male and 126 (75.9%) female (p < 0.0001), aged 71.7+/-5.2 years old (65 to 87 years old) were included in the study. After 12 months of intervention, only the waist circumference was significantly reduced in all the population (-2.5 cm, p<0.0001), although weight and BMI were maintained. MedDiet adherence increased significantly (p<0.001), but all intensity levels of PA decreased significantly (p<0.001). Concerning inflammatory biomarkers, only TNFa serum increased their levels after the intervention (p<0.001). Regarding the adipokine profile, adiponectin concentrations experienced a significant increment (p<0.001); besides, resistin concentrations decreased significantly (p<0.001). In this sense, only TNFa, adiponectin, and resistin correlated with PA. Adiponectin also correlates with insulin, triglycerides and HDL-c in baseline conditions and after 12 months of intervention; CRP, IL-6, TNFa, adiponectin, and resistin concentrations correlated with anthropometric parameters and some intensities of PA. In addition, adiponectin levels correlates with insulin, triglycerides and HDL-c. In baseline conditions, resistin levels correlated positively with TNFa (p = 0.01) and CRP (p<0.0001) levels. TNFa and IL-6 correlated positively with CRP (p = 0.03 and p<0.0001, respectively). After 12 months of intervention, only IL-6 correlated positively with CRP (p = 0.006). In addition, adipokines levels correlated positively during the process of lifestyle modification. However, during this process, only IL-6 correlated positively with itself (p<0.0001) and with CRP (p = 0.03).
+
+ CONCLUSION: Healthy aging is a multifactorial biological process in which lifestyle is essential. The presence of obesity in elderly metabolically healthy population is not a problem necessarily. Elderly MHO population who eat a MedDiet and practice regularly PA are capable to modulate their production of inflammatory cytokines (CRP, IL-6, TNFa) and adipokines profile (adiponectin, resistin), preventing other metabolic disorders.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (Insulins). 0 (Interleukin-6). 0 (Resistin). 0 (Triglycerides). 0 (Tumor Necrosis Factor-alpha). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1371%2fjournal.pone.0265362
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cobos-Palacios&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Metabolically+healthy+obesity%3A+Inflammatory+biomarkers+and+adipokines+in+elderly+population.&volume=17&issue=6&spage=e0265362&epage=&date=2022&doi=10.1371%2Fjournal.pone.0265362&pmid=35679338&sid=OVID:medline
+
+<478>
+Unique Identifier
+ 35679284
+Title
+ Causality of anthropometric markers associated with polycystic ovarian syndrome: Findings of a Mendelian randomization study.
+Source
+ PLoS ONE [Electronic Resource]. 17(6):e0269191, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ De Silva K; Demmer RT; Jonsson D; Mousa A; Teede H; Forbes A; Enticott J
+Author NameID
+ De Silva, Kushan; ORCID: https://orcid.org/0000-0003-0301-0805
+ Demmer, Ryan T; ORCID: https://orcid.org/0000-0003-3429-0379
+ Jonsson, Daniel; ORCID: https://orcid.org/0000-0001-8298-539X
+ Mousa, Aya; ORCID: https://orcid.org/0000-0002-7356-4523
+ Teede, Helena; ORCID: https://orcid.org/0000-0001-7609-577X
+Authors Full Name
+ De Silva, Kushan; Demmer, Ryan T; Jonsson, Daniel; Mousa, Aya; Teede, Helena; Forbes, Andrew; Enticott, Joanne.
+Institution
+ De Silva, Kushan. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia.
+ Demmer, Ryan T. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
+ Demmer, Ryan T. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America.
+ Jonsson, Daniel. Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmo, Sweden.
+ Jonsson, Daniel. Public Dental Service of Skane, Lund, Sweden.
+ Mousa, Aya. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia.
+ Teede, Helena. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia.
+ Forbes, Andrew. Biostatistics Unit, Division of Research Methodology, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
+ Enticott, Joanne. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Female
+ Humans
+ Mendelian Randomization Analysis
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Obesity, Abdominal/co [Complications]
+ Polycystic Ovary Syndrome/co [Complications]
+ Polycystic Ovary Syndrome/ge [Genetics]
+ *Polycystic Ovary Syndrome
+ Waist Circumference/ge [Genetics]
+Abstract
+ INTRODUCTION: Using body mass index (BMI) as a proxy, previous Mendelian randomization (MR) studies found total causal effects of general obesity on polycystic ovarian syndrome (PCOS). Hitherto, total and direct causal effects of general- and central obesity on PCOS have not been comprehensively analyzed.
+
+ OBJECTIVES: To investigate the causality of central- and general obesity on PCOS using surrogate anthropometric markers.
+
+ METHODS: Summary GWAS data of female-only, large-sample cohorts of European ancestry were retrieved for anthropometric markers of central obesity (waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR)) and general obesity (BMI and its constituent variables-weight and height), from the IEU Open GWAS Project. As the outcome, we acquired summary data from a large-sample GWAS (118870 samples; 642 cases and 118228 controls) within the FinnGen cohort. Total causal effects were assessed via univariable two-sample Mendelian randomization (2SMR). Genetic architectures underlying causal associations were explored. Direct causal effects were analyzed by multivariable MR modelling.
+
+ RESULTS: Instrumental variables demonstrated no weak instrument bias (F > 10). Four anthropometric exposures, namely, weight (2.69-77.05), BMI (OR: 2.90-4.06), WC (OR: 6.22-20.27), and HC (OR: 6.22-20.27) demonstrated total causal effects as per univariable 2SMR models. We uncovered shared and non-shared genetic architectures underlying causal associations. Direct causal effects of WC and HC on PCOS were revealed by two multivariable MR models containing exclusively the anthropometric markers of central obesity. Other multivariable MR models containing anthropometric markers of both central- and general obesity showed no direct causal effects on PCOS.
+
+ CONCLUSIONS: Both and general- and central obesity yield total causal effects on PCOS. Findings also indicated potential direct causal effects of normal weight-central obesity and more complex causal mechanisms when both central- and general obesity are present. Results underscore the importance of addressing both central- and general obesity for optimizing PCOS care.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1371%2fjournal.pone.0269191
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=De+Silva&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Causality+of+anthropometric+markers+associated+with+polycystic+ovarian+syndrome%3A+Findings+of+a+Mendelian+randomization+study.&volume=17&issue=6&spage=e0269191&epage=&date=2022&doi=10.1371%2Fjournal.pone.0269191&pmid=35679284&sid=OVID:medline
+
+<479>
+Unique Identifier
+ 35677049
+Title
+ A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes.
+Source
+ Frontiers in Immunology. 13:896179, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Seal SV; Henry M; Pajot C; Holuka C; Bailbe D; Movassat J; Darnaudery M; Turner JD
+Authors Full Name
+ Seal, Snehaa V; Henry, Mathilde; Pajot, Clementine; Holuka, Cyrielle; Bailbe, Danielle; Movassat, Jamileh; Darnaudery, Muriel; Turner, Jonathan D.
+Institution
+ Seal, Snehaa V. Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
+ Seal, Snehaa V. Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
+ Henry, Mathilde. Institut National de Recherche Pour l'agriculture, l'alimentation et l'environnement (INRAE), Bordeaux Institut National Polytechnique (INP), NutriNeuro, Unite Mixte de Recherche (UMR) 1286, University of Bordeaux, Bordeaux, France.
+ Pajot, Clementine. Institut National de Recherche Pour l'agriculture, l'alimentation et l'environnement (INRAE), Bordeaux Institut National Polytechnique (INP), NutriNeuro, Unite Mixte de Recherche (UMR) 1286, University of Bordeaux, Bordeaux, France.
+ Holuka, Cyrielle. Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
+ Holuka, Cyrielle. Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
+ Bailbe, Danielle. Universite de Paris, Laboratoire B2PE (Biologie et Pathologie du Pancreas Endocrine), Unite BFA (Biologie Fonctionnelle et Adaptative), Centre National de la Recherche Scientifique -Unite Mixte de Recherche (CNRS UMR) 8251, Paris, France.
+ Movassat, Jamileh. Universite de Paris, Laboratoire B2PE (Biologie et Pathologie du Pancreas Endocrine), Unite BFA (Biologie Fonctionnelle et Adaptative), Centre National de la Recherche Scientifique -Unite Mixte de Recherche (CNRS UMR) 8251, Paris, France.
+ Darnaudery, Muriel. Institut National de Recherche Pour l'agriculture, l'alimentation et l'environnement (INRAE), Bordeaux Institut National Polytechnique (INP), NutriNeuro, Unite Mixte de Recherche (UMR) 1286, University of Bordeaux, Bordeaux, France.
+ Turner, Jonathan D. Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Diabetes Mellitus, Type 2
+ Immune System
+ Obesity
+ Rats
+ Rats, Wistar
+Keyword Heading
+ Goto-Kakizaki rats
+ cytokines
+ diabetes
+ inflammation
+ microarrays
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats. Copyright © 2022 Seal, Henry, Pajot, Holuka, Bailbe, Movassat, Darnaudery and Turner.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffimmu.2022.896179
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Seal&issn=1664-3224&title=Frontiers+in+Immunology&atitle=A+Holistic+View+of+the+Goto-Kakizaki+Rat+Immune+System%3A+Decreased+Circulating+Immune+Markers+in+Non-+Obese+Type+2+Diabetes.&volume=13&issue=&spage=896179&epage=&date=2022&doi=10.3389%2Ffimmu.2022.896179&pmid=35677049&sid=OVID:medline
+
+<480>
+Unique Identifier
+ 35676031
+Title
+ Pediatric Metabolic Syndrome and the Marker of Abdominal Obesity.
+Source
+ Journal of Atherosclerosis & Thrombosis. 29(12):1693-1695, 2022 12 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dobashi K
+Authors Full Name
+ Dobashi, Kazushige.
+Institution
+ Dobashi, Kazushige. Department of Pediatrics, School of Medicine, University of Yamanashi.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Humans
+ Child
+ Obesity, Abdominal/di [Diagnosis]
+ *Obesity, Abdominal
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome
+ Obesity/me [Metabolism]
+ Body Mass Index
+ Biomarkers
+ Risk Factors
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.5551%2fjat.ED207
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dobashi&issn=1340-3478&title=Journal+of+Atherosclerosis+%26+Thrombosis&atitle=Pediatric+Metabolic+Syndrome+and+the+Marker+of+Abdominal+Obesity.&volume=29&issue=12&spage=1693&epage=1695&date=2022&doi=10.5551%2Fjat.ED207&pmid=35676031&sid=OVID:medline
+
+<481>
+Unique Identifier
+ 35674206
+Title
+ Obesity-associated biochemical markers of inflammation and the role of grain phytochemicals. [Review]
+Source
+ Journal of Food Biochemistry. 46(9):e14257, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Soujanya KV; Jayadeep AP
+Author NameID
+ Jayadeep, Appukuttan Padmanabhan; ORCID: https://orcid.org/0000-0002-8599-2496
+Authors Full Name
+ Soujanya, Kategowdru Vijayakumar; Jayadeep, Appukuttan Padmanabhan.
+Institution
+ Soujanya, Kategowdru Vijayakumar. Department of Grain Science and Technology, CSIR - Central Food Technological Research Institute, Mysuru, India.
+ Soujanya, Kategowdru Vijayakumar. Academy of Scientific and Innovative Research, CSIR - Central Food Technological Research Institute, Mysuru, India.
+ Jayadeep, Appukuttan Padmanabhan. Department of Grain Science and Technology, CSIR - Central Food Technological Research Institute, Mysuru, India.
+ Jayadeep, Appukuttan Padmanabhan. Academy of Scientific and Innovative Research, CSIR - Central Food Technological Research Institute, Mysuru, India.
+MeSH Subject Headings
+ Biomarkers
+ *Edible Grain
+ Inflammation/dt [Drug Therapy]
+ Millets
+ Obesity/dt [Drug Therapy]
+ Phytochemicals/pd [Pharmacology]
+ *Phytochemicals
+Keyword Heading
+ adipokines
+ grains
+ inflammation
+ obesity
+ phytochemicals
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The incidence of obesity or excessive fat accumulation in the body is increasing worldwide and has become one of the major growing health problems. Obese condition is linked with an increased level of body lipids, oxidative stress, and expression of inflammatory markers. This leads to plasma and hepatic hyperlipidemia, activation of proinflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and transcriptional factors, which in turn lead to a high risk of cardiovascular diseases, insulin resistance, diabetes, asthma, rheumatological problem, and liver failure. Grains are the major staple food crops grown for consumption in most of the developing countries. Cereals and millets, such as rice, wheat, maize, barley, finger millet, foxtail millet, proso millet, kodo millet in the whole form with bran, germ, and endosperm, are found to be rich in phytochemicals, such as phenolics acids, vitamin E, phytosterols, carotenoids, antioxidants, dietary fiber, which have a potential health benefit on various lifestyle disorders. In this article, we summarize the findings and investigations regarding the anti-inflammatory effect of various grain phytochemicals in in vitro and in vivo models and their potential health benefits. PRACTICAL APPLICATIONS: The occurrence of obesity is rising globally and is becoming a major health concern. Obesity will lead to multiple health problems due to oxidative and inflammatory stress in the body. Whole forms of cereals and millets consumptions have shown to reduce the risk of metabolic disorders and several chronic diseases. Potential bioactive components in various grains will act on the inhibition ofbiochemical markers connected with inflammation and adipogenesis. Copyright © 2022 Wiley Periodicals LLC.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phytochemicals).
+Publication Type
+ Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2fjfbc.14257
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Soujanya&issn=0145-8884&title=Journal+of+Food+Biochemistry&atitle=Obesity-associated+biochemical+markers+of+inflammation+and+the+role+of+grain+phytochemicals.&volume=46&issue=9&spage=e14257&epage=&date=2022&doi=10.1111%2Fjfbc.14257&pmid=35674206&sid=OVID:medline
+
+<482>
+Unique Identifier
+ 35669999
+Title
+ Markers of obesity in Danish pediatric liver transplantation recipients.
+Source
+ Pediatric Transplantation. 26(6):e14320, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Trier C; Schaffalitzky de Muckadell V; Borgwardt L; Rasmussen A; Horby Jorgensen M
+Author NameID
+ Trier, Caecilie; ORCID: https://orcid.org/0000-0001-5935-0863
+ Horby Jorgensen, Marianne; ORCID: https://orcid.org/0000-0003-0658-4636
+Authors Full Name
+ Trier, Caecilie; Schaffalitzky de Muckadell, Vibeke; Borgwardt, Lise; Rasmussen, Allan; Horby Jorgensen, Marianne.
+Institution
+ Trier, Caecilie. Department of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.
+ Trier, Caecilie. Department of Pediatric and Adolescent Medicine, University Hospital Holbaek, Holbaek, Denmark.
+ Trier, Caecilie. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
+ Schaffalitzky de Muckadell, Vibeke. Department of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.
+ Schaffalitzky de Muckadell, Vibeke. Department of Gynecology and Obstetrics, Hospital of Lillebaelt, Kolding, Denmark.
+ Borgwardt, Lise. Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark.
+ Rasmussen, Allan. Department of Surgical Gastroenterology and Transplantation, Rigshospitalet, Copenhagen, Denmark.
+ Horby Jorgensen, Marianne. Department of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers
+ Body Mass Index
+ Child
+ Child, Preschool
+ Denmark/ep [Epidemiology]
+ Humans
+ Liver Transplantation/ae [Adverse Effects]
+ *Liver Transplantation
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+ *Overweight
+ Young Adult
+Keyword Heading
+ lipids
+ liver
+ metabolic disorders
+ obesity
+ pediatric
+ transplantation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Long-time survivors of pediatric liver transplantation have an increased incidence of the metabolic syndrome. Adult recipients have an increased risk of post-transplantation obesity; however, pediatric data are limited.
+
+ METHODS: The study included 42 recipients of pediatric liver transplantation in Denmark, transplanted between 1990 and 2014. The study participants were examined with anthropometric measures, dual-energy X-ray scans and blood samples. From the anthropometric measures, body mass index (BMI) and BMI standard deviation score (SDS) were calculated. From the dual-energy X-ray scans, fat percent was assessed, and body fat mass index (BFMI) was calculated.
+
+ RESULTS: The median age was 17.4 years (range 4.1-38.9) at the time of the study, and the median time since transplantation was 8.5 years (range 0.4-23.9). The prevalence of overweight and obesity was 31.0% based on BMI SDS (age below 18) and BMI (age 18 and above). When compared to the participants with normal weight, the participants with overweight and obesity had a higher BFMI (9.29 vs 5.57 kg/m2 , p < .001) and fat percent (38.35% vs 29.50%, p = .006). They had higher levels of total cholesterol (4.3 vs 3.6 mmol/L, p = .023) and low-density lipoprotein (2.5 vs 1.7, p = .015), and had had longer time since transplantation (15.6 vs 8.5 years respectively, p = .045).
+
+ CONCLUSIONS: Long-time survivors of pediatric liver transplantation have a higher BMI or BMI SDS than the general pediatric population. The obesity is characterized by a higher BFMI, fat percent, and cholesterols levels, when compared to recipients without overweight or obesity. Copyright © 2022 The Authors. Pediatric Transplantation published by Wiley Periodicals LLC.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2fpetr.14320
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Trier&issn=1397-3142&title=Pediatric+Transplantation&atitle=Markers+of+obesity+in+Danish+pediatric+liver+transplantation+recipients.&volume=26&issue=6&spage=e14320&epage=&date=2022&doi=10.1111%2Fpetr.14320&pmid=35669999&sid=OVID:medline
+
+<483>
+Unique Identifier
+ 35667273
+Title
+ Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight.
+Source
+ Clinical Nutrition. 41(7):1566-1577, 2022 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lorenzo PM; Sajoux I; Izquierdo AG; Gomez-Arbelaez D; Zulet MA; Abete I; Castro AI; Baltar J; Portillo MP; Tinahones FJ; Martinez JA; Casanueva FF; Crujeiras AB
+Authors Full Name
+ Lorenzo, Paula M; Sajoux, Ignacio; Izquierdo, Andrea G; Gomez-Arbelaez, Diego; Zulet, M Angeles; Abete, Itziar; Castro, Ana I; Baltar, Javier; Portillo, Maria P; Tinahones, Francisco J; Martinez, J Alfredo; Casanueva, Felipe F; Crujeiras, Ana B.
+Institution
+ Lorenzo, Paula M. Epigenomics in Endocrinology and Nutrition Group, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Sajoux, Ignacio. Epigenomics in Endocrinology and Nutrition Group, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; Medical Department Pronokal Group, Barcelona, Spain.
+ Izquierdo, Andrea G. Epigenomics in Endocrinology and Nutrition Group, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Gomez-Arbelaez, Diego. Faculty of Health Sciences, University of Santander (UDES), Bucaramanga, Colombia.
+ Zulet, M Angeles. CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra (UNAV) and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
+ Abete, Itziar. CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra (UNAV) and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
+ Castro, Ana I. CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Molecular Endocrinology Group, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain.
+ Baltar, Javier. Division of General Surgery, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain.
+ Portillo, Maria P. CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, Spain; Bioaraba Health Research Institute, Vitoria-Gasteiz, Spain.
+ Tinahones, Francisco J. CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Complejo Hospitalario de Malaga (Virgen de La Victoria), Universidad de Malaga, Malaga, Spain.
+ Martinez, J Alfredo. CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra (UNAV) and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; Program for Precision Nutrition and Cardiometabolic Health, IMDEA, CSIC, Universidad Autonoma de Madrid (UAM), Madrid, Spain.
+ Casanueva, Felipe F. CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Molecular Endocrinology Group, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain. Electronic address: endocrine@usc.es.
+ Crujeiras, Ana B. Epigenomics in Endocrinology and Nutrition Group, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Spain; CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: anabelencrujeiras@hotmail.com.
+MeSH Subject Headings
+ *Bariatric Surgery
+ Biomarkers
+ Caloric Restriction
+ Carcinogenesis
+ Cytokines
+ Diet, Ketogenic/ae [Adverse Effects]
+ *Diet, Ketogenic
+ Diet, Reducing
+ Humans
+ *Ketosis
+ Lipid Peroxides
+ Obesity/su [Surgery]
+ Weight Gain
+ Weight Loss
+Keyword Heading
+ Immunonutrition
+ Inflammation
+ Nutritional ketosis
+ Obesity
+ Oxidative stress
+ PnK method
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIM: Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ketogenic diet (VLCKD) modulates the inflammatory and oxidative stress profile, compared with a standard, balanced hypocaloric diet (LCD) or bariatric surgery (BS) in patients with obesity.
+
+ METHODS: The study was performed in 79 patients with overweight or obesity and 32 normal-weight volunteers as the control group. Patients with obesity underwent a weight reduction therapy based on VLCKD, LCD or BS. The quantification of the circulating levels of a multiplexing test of cytokines and carcinogenesis/aging biomarkers, as well as of lipid peroxides and total antioxidant power, was carried out.
+
+ RESULTS: First, we observed that pro-inflammatory cytokines increase, while anti-inflammatory cytokines decrease under excessive body weight. Relevantly, when patients underwent weight loss strategies, it was shown that energy-restricted and surgical strategies of weight loss induced changes in circulating cytokine and lipid peroxides. This effect was more notable in patients following the VLCKD than the LCD or BS and it was observed mainly in the ketosis phase of the intervention. Particularly, IL-11, IL-12, IL-2, INF-gamma, INF-beta, Pentraxin-3 or MMP1 changed after VLCKD. Whereas, APRIL, TWEAK, osteocalcin and IL-28A increased after BS.
+
+ CONCLUSION: As far as we know, this is the first study that evaluate the time-course of cytokines and oxidative stress markers after a VLCKD as compared with a standard LCD and BS. The observed results support the immunomodulatory effect of nutritional ketosis induced by a VLCKD synergistically with weight loss as a strategy to improve innate-immunity and to prevent infections and carcinogenesis in patients with obesity. Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Lipid Peroxides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.clnu.2022.05.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lorenzo&issn=0261-5614&title=Clinical+Nutrition&atitle=Immunomodulatory+effect+of+a+very-low-calorie+ketogenic+diet+compared+with+bariatric+surgery+and+a+low-calorie+diet+in+patients+with+excessive+body+weight.&volume=41&issue=7&spage=1566&epage=1577&date=2022&doi=10.1016%2Fj.clnu.2022.05.007&pmid=35667273&sid=OVID:medline
+
+<484>
+Unique Identifier
+ 35655415
+Title
+ Haematological variables and risk of future venous thromboembolism in the British Regional Heart Study on men. Combined D-dimer and APTT as a predictive test for thromboembolism?.
+Source
+ British Journal of Haematology. 198(3):587-594, 2022 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wannamethee SG; Papacosta O; Lennon L; Whincup PH; Rumley A; Lowe GDO
+Author NameID
+ Wannamethee, S Goya; ORCID: https://orcid.org/0000-0001-9484-9977
+Authors Full Name
+ Wannamethee, S Goya; Papacosta, Olia; Lennon, Lucy; Whincup, Peter H; Rumley, Ann; Lowe, Gordon D O.
+Institution
+ Wannamethee, S Goya. Department of Primary Care and Population Health, UCL, Royal Free Campus, London, UK.
+ Papacosta, Olia. Department of Primary Care and Population Health, UCL, Royal Free Campus, London, UK.
+ Lennon, Lucy. Department of Primary Care and Population Health, UCL, Royal Free Campus, London, UK.
+ Whincup, Peter H. Population Health Research Institute, St George's, University of London, London, UK.
+ Rumley, Ann. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
+ Lowe, Gordon D O. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
+MeSH Subject Headings
+ Biomarkers
+ Fibrin Fibrinogen Degradation Products/ch [Chemistry]
+ *Fibrin Fibrinogen Degradation Products
+ Humans
+ Male
+ Obesity
+ Partial Thromboplastin Time
+ Risk Factors
+ Venous Thromboembolism/di [Diagnosis]
+ Venous Thromboembolism/ep [Epidemiology]
+ Venous Thromboembolism/et [Etiology]
+ *Venous Thromboembolism
+Keyword Heading
+ activated partial thromboplastin time
+ coagulation factor VIII
+ fibrin D-dimer
+ venous thromboembolism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We examined the associations between haematological and inflammatory variables with future venous thromboembolism (VTE), in 3494 men aged 60-79 years, with no previous history of VTE or myocardial infarction, who were not receiving oral anticoagulants. After a mean follow-up period of 18 years, there were 149 confirmed cases of fatal or non-fatal VTE (deep vein thrombosis and/or pulmonary embolism). Among classical cardiovascular risk factors, only obesity and cigarette smoking were associated with VTE risk. After adjustment for age, obesity and smoking, VTE risk was associated with coagulation factor VIII, factor IX, von Willebrand factor (VWF), activated partial thromboplastin time (APTT), and fibrin D-dimer. Hazard ratios (95% CI) for top to bottom quarters (bottom to top for APTT), were respectively 2.17 (1.37, 3.44), 2.15 (1.30, 3.53), 2.02 (1.27, 3.22), 2.43 (1.47, 4.02) and 3.62 (2.18, 6.08). The 11% of men with both the shortest APTT and highest D-dimer combined had a 5.02 (2.37, 10.62) higher risk of VTE. VTE risk was not associated with fibrinogen, factor VII or activated protein C resistance; full blood count variables or with inflammatory markers, plasma viscosity, C-reactive protein or interleukin-6. The combination of D-dimer and APTT merits evaluation as an adjunct to VTE risk prediction scores. Copyright © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fibrin Fibrinogen Degradation Products). 0 (fibrin fragment D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2fbjh.18288
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wannamethee&issn=0007-1048&title=British+Journal+of+Haematology&atitle=Haematological+variables+and+risk+of+future+venous+thromboembolism+in+the+British+Regional+Heart+Study+on+men.+Combined+D-dimer+and+APTT+as+a+predictive+test+for+thromboembolism%3F.&volume=198&issue=3&spage=587&epage=594&date=2022&doi=10.1111%2Fbjh.18288&pmid=35655415&sid=OVID:medline
+
+<485>
+Unique Identifier
+ 35654771
+Title
+ Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention.
+Source
+ Nutrition & Diabetes. 12(1):30, 2022 06 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Senkus KE; Crowe-White KM; Bolland AC; Locher JL; Ard JD
+Author NameID
+ Senkus, Katelyn E; ORCID: https://orcid.org/0000-0002-1711-398X
+ Crowe-White, Kristi M; ORCID: https://orcid.org/0000-0003-2497-4582
+Authors Full Name
+ Senkus, Katelyn E; Crowe-White, Kristi M; Bolland, Anneliese C; Locher, Julie L; Ard, Jamy D.
+Institution
+ Senkus, Katelyn E. Department of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.
+ Crowe-White, Kristi M. Department of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA. kcrowe@ches.ua.edu.
+ Bolland, Anneliese C. College of Communication and Information Sciences, Communication Studies & Institute for Communication and Information Research, The University of Alabama, Tuscaloosa, AL, USA.
+ Locher, Julie L. Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Ard, Jamy D. Wake Forest University School of Medicine, Department of Epidemiology and Prevention, Winston-Salem, NC, USA.
+MeSH Subject Headings
+ Adiponectin/me [Metabolism]
+ Aged
+ Biomarkers
+ *Cardiovascular Diseases
+ Diet, Reducing
+ Female
+ Humans
+ Leptin/me [Metabolism]
+ *Leptin
+ Male
+ Obesity/me [Metabolism]
+ Weight Loss
+Abstract
+ BACKGROUND: Excess adiposity is characterized by alterations in adipokine secretion such that circulating leptin concentrations are increased with reductions in adiponectin. An emerging biomarker for the assessment of this adipose tissue (AT) dysfunction is the adiponectin:leptin (AL) ratio. A low AL ratio may be suggestive of dysfunctional AT and, consequently, a heightened cardiometabolic disease risk. This ancillary study investigated the relationship between the AL ratio and cardiometabolic health among community-dwelling older adults with obesity, as well as the effects of a 12-month exercise and diet intervention on changes in the AL ratio.
+
+ METHODS: Participants (n = 163, 70.2 +/- 4.7 years, 38.0% male) were randomized to the exercise only group, exercise + nutrient-dense weight maintenance group (exercise + weight maintenance), or exercise + nutrient-dense caloric restriction of 500 kcal/d group (exercise + intentional weight loss) (clinicaltrials.gov #NCT00955903). Total and regional adiposity as determined by magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA), anthropometrics, and cardiometabolic biomarkers were assessed at baseline and 12 months.
+
+ RESULTS: The AL ratio was significantly (p < 0.05) inversely correlated with body mass index, waist circumference, measures of adiposity, and insulin among all participants at baseline. Among females only, significant positive and inverse correlations were also observed between this ratio and high-density lipoprotein cholesterol and the inflammatory biomarkers high sensitivity C-reactive protein and interleukin-6, respectively. While controlling for biological sex, a significant time by intervention group interaction effect (p < 0.05) was observed such that the AL ratio significantly increased from baseline to study completion among participants in the exercise + weight maintenance group and exercise + intentional weight loss group. Post hoc analysis revealed that the exercise + intentional weight loss group exhibited a significantly greater AL ratio at study completion compared to other groups (p < 0.05 all).
+
+ CONCLUSIONS: Results are in support of the AL ratio as a measure of AT dysfunction among older adults. Furthermore, results suggest that a 12-month exercise and diet intervention with intentional weight loss assists in improving the AL ratio in this population. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41387-022-00207-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Senkus&issn=2044-4052&title=Nutrition+%26+Diabetes&atitle=Changes+in+adiponectin%3Aleptin+ratio+among+older+adults+with+obesity+following+a+12-month+exercise+and+diet+intervention.&volume=12&issue=1&spage=30&epage=&date=2022&doi=10.1038%2Fs41387-022-00207-1&pmid=35654771&sid=OVID:medline
+
+<486>
+Unique Identifier
+ 35648345
+Title
+ Evaluation of antiobesity and hepatorenal protective activities of Salvia officinalis extracts pre-treatment in high-fat diet-induced obese rats.
+Source
+ Environmental Science & Pollution Research. 29(49):75043-75056, 2022 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Othman MS; Khaled AM; Aleid GM; Fareid MA; Hameed RA; Abdelfattah MS; Aldin DE; Moneim AEA
+Authors Full Name
+ Othman, Mohamed S; Khaled, Azza M; Aleid, Ghada M; Fareid, Mohamed A; Hameed, Reda A; Abdelfattah, Mohamed S; Aldin, Doaa Ezz; Moneim, Ahmed E Abdel.
+Institution
+ Othman, Mohamed S. Basic Sciences Department, Deanship of Preparatory Year, University of Ha'il, Hail, Saudi Arabia. biostar55@yahoo.com.
+ Othman, Mohamed S. Faculty of Biotechnology, October University for Modern Science and Arts (MSA), Giza, Egypt. biostar55@yahoo.com.
+ Khaled, Azza M. Basic Sciences Department, Deanship of Preparatory Year, University of Ha'il, Hail, Saudi Arabia.
+ Khaled, Azza M. National Institute of Oceanography and Fisheries, Cairo, Egypt.
+ Aleid, Ghada M. Basic Sciences Department, Deanship of Preparatory Year, University of Ha'il, Hail, Saudi Arabia.
+ Fareid, Mohamed A. Basic Sciences Department, Deanship of Preparatory Year, University of Ha'il, Hail, Saudi Arabia.
+ Fareid, Mohamed A. Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
+ Hameed, Reda A. Basic Sciences Department, Deanship of Preparatory Year, University of Ha'il, Hail, Saudi Arabia.
+ Hameed, Reda A. Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
+ Abdelfattah, Mohamed S. Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
+ Aldin, Doaa Ezz. Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt.
+ Moneim, Ahmed E Abdel. Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt.
+MeSH Subject Headings
+ Animals
+ Antioxidants/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Body Weight
+ Creatinine
+ Diet, High-Fat/ae [Adverse Effects]
+ Flavonoids/pd [Pharmacology]
+ Inflammation Mediators/me [Metabolism]
+ Inflammation Mediators/pd [Pharmacology]
+ Inflammation Mediators/tu [Therapeutic Use]
+ Insulins/me [Metabolism]
+ Insulins/pd [Pharmacology]
+ Insulins/tu [Therapeutic Use]
+ *Insulins
+ Interleukin-1beta/me [Metabolism]
+ Leptin
+ Lipids
+ NF-E2-Related Factor 2/me [Metabolism]
+ Nitric Oxide/pd [Pharmacology]
+ Obesity
+ Oxidative Stress
+ PPAR gamma/me [Metabolism]
+ PPAR gamma/pd [Pharmacology]
+ PPAR gamma/tu [Therapeutic Use]
+ Plant Extracts/pd [Pharmacology]
+ Plant Extracts/tu [Therapeutic Use]
+ Rats
+ *Salvia officinalis
+ Simvastatin
+ Superoxide Dismutase/me [Metabolism]
+ Tumor Necrosis Factor-alpha/me [Metabolism]
+ Urea/pd [Pharmacology]
+Keyword Heading
+ Flavonoids
+ High-fat diet
+ Obesity
+ Oxidative stress
+ Salvia officinalis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The present study evaluated the effects of Hail Salvia officinalis total extract (SOTE) and its high flavonoid fraction (SOHFF) on the high-fat diet (HFD)-induced obesity and hepatorenal damage in rats. Salvia officinalis plants were collected from Hail region, Saudi Arabia. Rats were fed HFD and supplemented orally with SOTE (250 mg kg-1) or SOHFF (100 mg kg-1) or simvastatin (SVS; 10 mg kg-1) every day for 8 weeks. Compared to the controls, HFD-induced obesity led to significant increases in body weight, body weight gained, blood insulin, leptin, cardiac enzymes (LDH and CPK) activity, and atherogenic index (AI). HFD rats also showed higher levels of hepatic and renal function biomarkers (ALT, urea, and creatinine), as well as lower levels of PPARgamma and Nrf2-gene expression and a disrupted lipid profile. Moreover, HFD rats had lower levels of hepatic and renal antioxidant biomarkers (CAT, GPx, SOD, GR, and GSH), accompanied by higher levels of hepatic and renal lipid peroxidation (LPO), nitric oxide (NO), and inflammatory mediators (interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha)). In addition, histological examination of hepatic and renal tissues revealed histopathological changes that validated the biochemical findings. Compared to HFD group, SOTE and SOHFF treatment led to marked amelioration of all the aforementioned parameters. Collectively, supplementation with SOTE and SOHFF effectively reversed HFD-induced alterations through its antioxidant, hypolipidemic, and anti-inflammatory properties. Hence, SOTE and SOHFF have therapeutic potential in controlling obesity and related pathologies. Copyright © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Flavonoids). 0 (Inflammation Mediators). 0 (Insulins). 0 (Interleukin-1beta). 0 (Leptin). 0 (Lipids). 0 (NF-E2-Related Factor 2). 0 (PPAR gamma). 0 (Plant Extracts). 0 (Tumor Necrosis Factor-alpha). 31C4KY9ESH (Nitric Oxide). 8W8T17847W (Urea). AGG2FN16EV (Simvastatin). AYI8EX34EU (Creatinine). EC 1-15-1-1 (Superoxide Dismutase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs11356-022-21092-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Othman&issn=0944-1344&title=Environmental+Science+%26+Pollution+Research&atitle=Evaluation+of+antiobesity+and+hepatorenal+protective+activities+of+Salvia+officinalis+extracts+pre-treatment+in+high-fat+diet-induced+obese+rats.&volume=29&issue=49&spage=75043&epage=75056&date=2022&doi=10.1007%2Fs11356-022-21092-2&pmid=35648345&sid=OVID:medline
+
+<487>
+Unique Identifier
+ 35644526
+Title
+ Association of fetal fraction with hypertensive disorders of pregnancy incidence and disease severity.
+Source
+ American Journal of Obstetrics & Gynecology MFM. 4(5):100671, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shree R; Kolarova TR; MacKinnon HJ; Lockwood CM; Chandrasekaran S
+Authors Full Name
+ Shree, Raj; Kolarova, Teodora R; MacKinnon, Hayley J; Lockwood, Christina M; Chandrasekaran, Suchitra.
+Institution
+ Shree, Raj. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA (Drs Shree, Kolarova, Mackinnon, and Chandrasekaran). Electronic address: shreer23@uw.edu.
+ Kolarova, Teodora R. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA (Drs Shree, Kolarova, Mackinnon, and Chandrasekaran).
+ MacKinnon, Hayley J. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA (Drs Shree, Kolarova, Mackinnon, and Chandrasekaran).
+ Lockwood, Christina M. Department of Laboratory Medicine, University of Washington, Seattle, WA (Dr Lockwood).
+ Chandrasekaran, Suchitra. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA (Drs Shree, Kolarova, Mackinnon, and Chandrasekaran); Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Emory University, Atlanta, GA (Dr Chandrasekaran).
+MeSH Subject Headings
+ Biomarkers
+ *Cell-Free Nucleic Acids
+ Female
+ Humans
+ Hypertension, Pregnancy-Induced/di [Diagnosis]
+ Hypertension, Pregnancy-Induced/ep [Epidemiology]
+ Hypertension, Pregnancy-Induced/et [Etiology]
+ *Hypertension, Pregnancy-Induced
+ Incidence
+ Male
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Placenta
+ Pregnancy
+ Retrospective Studies
+ Severity of Illness Index
+Keyword Heading
+ cell-free DNA
+ fetal fraction
+ hypertensive disorders of pregnancy
+ obesity
+ preeclampsia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hypertensive disorders of pregnancy contribute to maternal and offspring morbidity and mortality. Studies suggest that a lower early pregnancy fetal fraction is associated with an increased risk of hypertensive disorders of pregnancy. However, maternal obesity significantly affects fetal fraction and is a risk factor for hypertensive disorders of pregnancy.
+
+ OBJECTIVE: We determined the association between fetal fraction (using a standardized single-institution platform, including male and female fetuses) and hypertensive disorders of pregnancy, stratified by obesity status. Second, we evaluated differences in total cell-free DNA concentration and correlation of fetal fraction with clinical markers of hypertensive disorders of pregnancy severity.
+
+ STUDY DESIGN: This was a retrospective, single-institution study of a previously validated cell-free DNA-based noninvasive prenatal screening assay of 1058 samples. Maternal body mass index at the time of noninvasive prenatal screening was assessed, and hypertensive disorders of pregnancy were confirmed by a detailed medical record review. Differences in fetal fraction and total cell-free DNA concentration between the groups were assessed with univariate analyses. Multivariable regression was used to evaluate the association between fetal fraction and hypertensive disorders of pregnancy, adjusted for body mass index, maternal age, gestational age at noninvasive prenatal screening, and fetal sex. The association between fetal fraction and hypertensive disorders of pregnancy among individuals with obesity (body mass index, >=30 kg/m2) and individuals without obesity (body mass index, <30 kg/m2) was investigated while controlling for the aforementioned covariates. Lastly, multivariable linear regression was used to evaluate the association between fetal fraction and clinical markers of hypertensive disorders of pregnancy severity.
+
+ RESULTS: We identified individuals with (n=117) and without (n=941) hypertensive disorders of pregnancy with noninvasive prenatal screening drawn before 20 weeks of gestation and with fetal fraction and body mass index data available. Those with hypertensive disorders of pregnancy had a lower fetal fraction (10.2%+/-4.2% vs 11.6%+/-4.7%; P<.01), without differences in total cell-free DNA concentration (P=.14). When groups were stratified by obesity status, this relationship was only valid for individuals without obesity (P=.02). Only when logistic regression analysis was restricted to individuals without obesity did the likelihood of hypertensive disorders of pregnancy rise with decreasing fetal fraction (odds ratio, 0.93; 95% confidence interval, 0.88-0.99; P=.02). In addition, fetal fraction was inversely associated with maximum systolic blood pressure at the time of hypertensive disorders of pregnancy only in the population without obesity (beta, -0.08; 95% confidence interval, -0.147 to -0.01; P=.02).
+
+ CONCLUSION: Although a lower fetal fraction is associated with the development of hypertensive disorders of pregnancy, the use of this parameter for the prediction may be problematic in individuals with obesity, as obesity has such a profound effect on fetal fraction. However, we uniquely noted that among individuals without obesity, fetal fraction is lower for those that develop hypertensive disorders of pregnancy and lower fetal fraction increases the odds of hypertensive disorders of pregnancy development. Lastly, low fetal fraction in the population without obesity that developed hypertensive disorders of pregnancy was associated with higher systolic blood pressure at the time of hypertensive disorders of pregnancy, an important clinical marker of hypertensive disorders of pregnancy severity. As analytical approaches of cell-free DNA interrogation advance, the prediction of placental-mediated disorders with first-trimester sampling is likely to improve, although this may remain challenging in gravidas with obesity, a cohort at high risk of developing hypertensive disorders of pregnancy. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cell-Free Nucleic Acids).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.ajogmf.2022.100671
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shree&issn=2589-9333&title=American+Journal+of+Obstetrics+%26+Gynecology+MFM&atitle=Association+of+fetal+fraction+with+hypertensive+disorders+of+pregnancy+incidence+and+disease+severity.&volume=4&issue=5&spage=100671&epage=&date=2022&doi=10.1016%2Fj.ajogmf.2022.100671&pmid=35644526&sid=OVID:medline
+
+<488>
+Unique Identifier
+ 35641515
+Title
+ Interactions between Caveolin-1 polymorphism and Plant-based dietary index on metabolic and inflammatory markers among women with obesity.
+Source
+ Scientific Reports. 12(1):9088, 2022 05 31.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abaj F; Mirzababaei A; Hosseininasab D; Bahrampour N; Clark CCT; Mirzaei K
+Authors Full Name
+ Abaj, Faezeh; Mirzababaei, Atieh; Hosseininasab, Dorsa; Bahrampour, Niki; Clark, Cain C T; Mirzaei, Khadijeh.
+Institution
+ Abaj, Faezeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Mirzababaei, Atieh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Hosseininasab, Dorsa. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
+ Bahrampour, Niki. Department of Nutrition, Science and Research Branch, Islamic Azad University (SRBIAU), Tehran, Iran.
+ Clark, Cain C T. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, UK.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran. mirzaei_kh@sina.tums.ac.ir.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Caveolin 1/ge [Genetics]
+ *Caveolin 1
+ *Diet
+ Female
+ Humans
+ Insulins
+ Middle Aged
+ Obesity/ge [Genetics]
+ *Obesity
+ Polymorphism, Genetic
+Abstract
+ A series of recent studies have indicated that the Caveolin-1 (CAV-1) gene variant may be associated with metabolic and inflammatory markers and anthropometric measures. Furthermore, it has been shown that a plant-based dietary index (PDI) can elicit a positive impact on these metabolic markers. Therefore, we sought to examine whether PDI intakes may affect the relationship between CAV-1 (rs3807992) and metabolic factors, as well as serum inflammatory markers and anthropometric measures, in women with obesity. This current study consisted of 400 women with overweight and obesity, with a mean (SD) age of 36.67 +/- 9.10 years. PDI was calculated by a food frequency questionnaire (FFQ). The anthropometric measurements and serum profiles were measured by standard protocols. Genotyping of the CAV-1(rs3807992) was conducted by the PCR-RFLP method. The following genotypic frequencies were found among the participants: GG (47.8%), AG (22.3%), and AA (2.3%). In comparison to GG homozygotes, risk-allele carriers (AA + AG) with higher PDI intake had lower ALT (P: 0.03), hs-CRP (P: 0.008), insulin (P: 0.01) and MCP-1 (P: 0.04). Furthermore, A-allele carriers were characterized by lower serum ALT (P: 0.04), AST (P: 0.02), insulin (P: 0.03), and TGF-beta (P: 0.001) when had the higher following a healthful PDI compared to GG homozygote. Besides, risk-allele carriers who consumed higher unhealthful PDI had higher WC (P: 0.04), TC/HDL (P: 0.04), MCP-1 (P: 0.03), and galactin-3 (P: 0.04). Our study revealed that A-allele carriers might be more sensitive to PDI composition compared to GG homozygotes. Following a healthful PDI in A-allele carriers may be associated with improvements in metabolic and inflammatory markers and anthropometric measures. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CAV1 protein, human). 0 (Caveolin 1). 0 (Insulins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1038%2fs41598-022-12913-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abaj&issn=2045-2322&title=Scientific+Reports&atitle=Interactions+between+Caveolin-1+polymorphism+and+Plant-based+dietary+index+on+metabolic+and+inflammatory+markers+among+women+with+obesity.&volume=12&issue=1&spage=9088&epage=&date=2022&doi=10.1038%2Fs41598-022-12913-y&pmid=35641515&sid=OVID:medline
+
+<489>
+Unique Identifier
+ 35637082
+Title
+ Increased sedentary time and decreased physical activity increases lipoprotein associated phospholipase A2 in obese individuals.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 32(7):1703-1710, 2022 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Clark K; Sharp S; Womack CJ; Kurti SP; Hargens TA
+Authors Full Name
+ Clark, Kendall; Sharp, Sydney; Womack, Christopher J; Kurti, Stephanie P; Hargens, Trent A.
+Institution
+ Clark, Kendall. Human Performance Laboratory, Department of Kinesiology, James Madison University, 261 Bluestone Dr MSC 2302, Harrisonburg, VA, 22807, USA. Electronic address: clarkkg@dukes.jmu.edu.
+ Sharp, Sydney. Human Performance Laboratory, Department of Kinesiology, James Madison University, 261 Bluestone Dr MSC 2302, Harrisonburg, VA, 22807, USA. Electronic address: sharpsc@dukes.jmu.edu.
+ Womack, Christopher J. Human Performance Laboratory, Department of Kinesiology, James Madison University, 261 Bluestone Dr MSC 2302, Harrisonburg, VA, 22807, USA. Electronic address: womackcx@jmu.edu.
+ Kurti, Stephanie P. Human Performance Laboratory, Department of Kinesiology, James Madison University, 261 Bluestone Dr MSC 2302, Harrisonburg, VA, 22807, USA. Electronic address: kurtisp@jmu.edu.
+ Hargens, Trent A. Department of Kinesiology, James Madison University, 261 Bluestone Dr. MSC 2302, Harrisonburg, VA, 22807, USA. Electronic address: hargenta@jmu.edu.
+MeSH Subject Headings
+ 1-Alkyl-2-acetylglycerophosphocholine Esterase
+ Biomarkers
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Exercise
+ Humans
+ Lipoproteins
+ Obesity
+ Risk Factors
+ Sedentary Behavior
+ *Sleep Apnea, Obstructive
+Keyword Heading
+ Inflammation
+ Lipoprotein-associated phospholipase A(2)
+ Obesity
+ Physical activity
+ Sedentary
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Lipoprotein-associated Phospholipase A2 (Lp-PLA2) is a protein produced by inflammatory cells in circulation and is associated with cardiovascular disease (CVD) risk. Physical activity (PA) is known to reduce inflammation and risk for CVD. However, Lp-PLA2 has yet to be examined in relation to PA and sedentary time. The purpose of this study was to determine if PA and sedentary time impacts Lp-PLA2 mass. A total of 25 subjects with an average BMI of 30.6 +/- 5.7 were included in the data analysis.
+
+ METHODS AND RESULTS: Data collected included anthropometric data, Lp-PLA2 mass, peak oxygen uptake (VO2peak), resting heart rate and blood pressure, obstructive sleep apnea (OSA) risk, and assessment of PA using an accelerometer. Sedentary minutes per day was positively associated with Lp-PLA2 (r = 0.41, P < 0.05). Light intensity PA was negatively associated (r = -0.51. P = 0.01) with Lp-PLA2. When subjects were divided into 2-quantiles by Lp-PLA2, the group with the higher Lp-PLA2 mass accumulated more sedentary time per day (P < 0.001) and less light intensity PA per day (P = 0.001). OSA risk and Lp-PLA2 showed no relationship. Sedentary behavior was higher, and light intensity PA was lower in subjects with hiLp-PLA2 mass. No difference was seen in moderate-to-vigorous intensity PA or steps per day.
+
+ CONCLUSIONS: This suggests that, total PA habits, including time spent sedentary and lower intensity PA, impacts the levels of Lp-PLA2, an important inflammatory marker and marker of CVD risk. Copyright © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipoproteins). EC 3-1-1-47 (1-Alkyl-2-acetylglycerophosphocholine Esterase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.numecd.2022.04.023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Clark&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Increased+sedentary+time+and+decreased+physical+activity+increases+lipoprotein+associated+phospholipase+A2+in+obese+individuals.&volume=32&issue=7&spage=1703&epage=1710&date=2022&doi=10.1016%2Fj.numecd.2022.04.023&pmid=35637082&sid=OVID:medline
+
+<490>
+Unique Identifier
+ 35620390
+Title
+ High-Sensitive CRP Correlates With the Severity of Liver Steatosis and Fibrosis in Obese Patients With Metabolic Dysfunction Associated Fatty Liver Disease.
+Source
+ Frontiers in Endocrinology. 13:848937, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhu C; Huang D; Ma H; Qian C; You H; Bu L; Qu S
+Authors Full Name
+ Zhu, Cuiling; Huang, Dongdong; Ma, Huihui; Qian, Chunhua; You, Hui; Bu, Le; Qu, Shen.
+Institution
+ Zhu, Cuiling. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Zhu, Cuiling. National Metabolic Management Center, School of Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
+ Huang, Dongdong. Department of Respiratory Medicine, School of Medicine, Shanghai Pulmonary Hospital of Tongji University, Shanghai, China.
+ Ma, Huihui. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Ma, Huihui. National Metabolic Management Center, School of Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
+ Qian, Chunhua. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Qian, Chunhua. National Metabolic Management Center, School of Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
+ You, Hui. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ You, Hui. National Metabolic Management Center, School of Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
+ Bu, Le. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Bu, Le. National Metabolic Management Center, School of Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
+ Qu, Shen. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Qu, Shen. National Metabolic Management Center, School of Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
+MeSH Subject Headings
+ Biomarkers
+ *C-Reactive Protein
+ *Fatty Liver
+ Fibrosis
+ Humans
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+Keyword Heading
+ hepatic fibrosis
+ high-sensitive C-reactive protein
+ inflammation
+ metabolic dysfunction associated fatty liver disease
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Metabolic dysfunction associated fatty liver disease (MAFLD) is the most common hepatopathy worldwide due to the obesity epidemic and is associated with chronic low-grade inflammation. High-sensitive C-reactive protein (hsCRP) as an inflammatory marker has been used in diagnosing MAFLD. However, the association between hsCRP and the severity of liver steatosis and fibrosis among obese patients with MAFLD remains to be elucidated.
+
+ Objective: To explore the correlation of hsCRP with the severity of liver steatosis and fibrosis among Chinese obese patients with MAFLD.
+
+ Methods: A total of 393 obese patients with mean BMI 34.8 +/- 6.6 kg/m2 were selected and categorized as MAFLD and non-MAFLD groups. Anthropometric data, biochemical indices, and hsCRP were measured. The severity of hepatic steatosis and fibrosis was assessed using FibroScan. Multivariate logistic regression analysis was performed to determine the relationship between hsCRP and the risk of MAFLD and its disease severity.
+
+ Results: Patients with MAFLD showed significantly elevated hsCRP levels and were more likely to have severe steatosis and fibrosis compared to those without MAFLD. The proportions of MAFLD, severe steatosis, and severe fibrosis were significantly increased across the hsCRP quartiles (P-trend = 0.004, 0.021, and 0.006, respectively). After multivariable adjustments, the adjusted ORs (AORs) and 95%CI for MAFLD were 1.00 (reference), 1.298 (0.587-2.872), 2.407 (1.002-5.781), and 2.637(1.073-6.482) (Q1-Q4, P-trend = 0.014). Likewise, the AORs (95%CI) for severe steatosis and severe fibrosis were remarkably increased with the increment of serum hsCRP quartiles (P-trend < 0.001, P-trend = 0.021, respectively).
+
+ Conclusions: Elevated serum hsCRP levels were associated with increased risk of MAFLD among Chinese obese patients and correlated positively with the severity of liver steatosis and fibrosis, suggesting that hsCRP can be used as a potential biomarker to monitor and predict disease severity among Chinese obese population with MAFLD. Copyright © 2022 Zhu, Huang, Ma, Qian, You, Bu and Qu.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.848937
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhu&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=High-Sensitive+CRP+Correlates+With+the+Severity+of+Liver+Steatosis+and+Fibrosis+in+Obese+Patients+With+Metabolic+Dysfunction+Associated+Fatty+Liver+Disease.&volume=13&issue=&spage=848937&epage=&date=2022&doi=10.3389%2Ffendo.2022.848937&pmid=35620390&sid=OVID:medline
+
+<491>
+Unique Identifier
+ 35610699
+Title
+ Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.
+Source
+ Respiratory Research. 23(1):131, 2022 May 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ihrie MD; McQuade VL; Womble JT; Hegde A; McCravy MS; Lacuesta CVG; Tighe RM; Que LG; Walker JKL; Ingram JL
+Authors Full Name
+ Ihrie, Mark D; McQuade, Victoria L; Womble, Jack T; Hegde, Akhil; McCravy, Matthew S; Lacuesta, Cyrus Victor G; Tighe, Robert M; Que, Loretta G; Walker, Julia K L; Ingram, Jennifer L.
+Institution
+ Ihrie, Mark D. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA.
+ McQuade, Victoria L. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA.
+ Womble, Jack T. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA.
+ Hegde, Akhil. School of Nursing, Duke University, Durham, NC, USA.
+ McCravy, Matthew S. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA.
+ Lacuesta, Cyrus Victor G. School of Nursing, Duke University, Durham, NC, USA.
+ Tighe, Robert M. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA.
+ Que, Loretta G. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA.
+ Walker, Julia K L. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA.
+ Walker, Julia K L. School of Nursing, Duke University, Durham, NC, USA.
+ Ingram, Jennifer L. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA. jennifer.ingram@duke.edu.
+MeSH Subject Headings
+ Allergens
+ Animals
+ Asthma/me [Metabolism]
+ *Asthma
+ Biomarkers/me [Metabolism]
+ Bronchoalveolar Lavage Fluid
+ Disease Models, Animal
+ Female
+ Fibrosis
+ Humans
+ Hypersensitivity/me [Metabolism]
+ *Hypersensitivity
+ Leptin
+ Lung/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred BALB C
+ Mice, Inbred C57BL
+ Obesity/me [Metabolism]
+ Pulmonary Disease, Chronic Obstructive/me [Metabolism]
+ *Pulmonary Disease, Chronic Obstructive
+ Pulmonary Fibrosis/me [Metabolism]
+ *Pulmonary Fibrosis
+ Pyroglyphidae
+ RNA, Messenger/me [Metabolism]
+Keyword Heading
+ Airway remodeling
+ Asthma
+ Leptin
+ Sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that is increased in obesity is leptin. We hypothesized that in a mouse model of allergic airways disease, mice receiving exogenous leptin would display increased airway inflammation and fibrosis.
+
+ METHODS: Five-week-old male and female C57BL/6J mice were challenged with intranasal house dust mite (HDM) allergen or saline 5 days per week for 6 weeks (n = 6-9 per sex, per group). Following each HDM exposure, mice received subcutaneous recombinant human leptin or saline. At 48 h after the final HDM challenge, lung mechanics were evaluated and the mice were sacrificed. Bronchoalveolar lavage was performed and differential cell counts were determined. Lung tissue was stained with Masson's trichrome, periodic acid-Schiff, and hematoxylin and eosin stains. Mouse lung fibroblasts were cultured, and whole lung mRNA was isolated.
+
+ RESULTS: Leptin did not affect mouse body weight, but HDM+leptin increased baseline blood glucose. In mixed-sex groups, leptin increased mouse lung fibroblast invasiveness and increased lung Col1a1 mRNA expression. Total lung resistance and tissue damping were increased with HDM+leptin treatment, but not leptin or HDM alone. Female mice exhibited enhanced airway responsiveness to methacholine with HDM+leptin treatment, while leptin alone decreased total respiratory system resistance in male mice.
+
+ CONCLUSIONS: In HDM-induced allergic airways disease, administration of exogenous leptin to mice enhanced lung resistance and increased markers of fibrosis, with differing effects between males and females. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Allergens). 0 (Biomarkers). 0 (Leptin). 0 (RNA, Messenger).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12931-022-02048-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ihrie&issn=1465-9921&title=Respiratory+Research&atitle=Exogenous+leptin+enhances+markers+of+airway+fibrosis+in+a+mouse+model+of+chronic+allergic+airways+disease.&volume=23&issue=1&spage=131&epage=&date=2022&doi=10.1186%2Fs12931-022-02048-z&pmid=35610699&sid=OVID:medline
+
+<492>
+Unique Identifier
+ 35608825
+Title
+ Mitochondrial Homeostasis in Obesity-related Hypertriglyceridemia.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 107(8):2203-2215, 2022 07 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mela V; Ruiz-Limon P; Balongo M; Motahari Rad H; Subiri-Verdugo A; Gonzalez-Jimenez A; Soler R; Ocana L; El Azzouzi H; Tinahones FJ; Valdivielso P; Murri M
+Author NameID
+ Mela, Virginia; ORCID: https://orcid.org/0000-0001-7702-0972
+ Murri, Mora; ORCID: https://orcid.org/0000-0002-6482-192X
+Authors Full Name
+ Mela, Virginia; Ruiz-Limon, Patricia; Balongo, Manuel; Motahari Rad, Hanieh; Subiri-Verdugo, Alba; Gonzalez-Jimenez, Andres; Soler, Rocio; Ocana, Luis; El Azzouzi, Hamid; Tinahones, Francisco J; Valdivielso, Pedro; Murri, Mora.
+Institution
+ Mela, Virginia. Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+ Mela, Virginia. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 29010, Malaga, Spain.
+ Mela, Virginia. Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, 29010, Malaga, Spain.
+ Ruiz-Limon, Patricia. Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+ Balongo, Manuel. Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+ Motahari Rad, Hanieh. Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+ Motahari Rad, Hanieh. Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, 14115-154, Tehran, Iran.
+ Subiri-Verdugo, Alba. Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+ Gonzalez-Jimenez, Andres. ECAI bioinformatic Institute of biomedical research of Malaga (IBIMA), 29010 Malaga, Spain.
+ Soler, Rocio. Unidad de Gestion Clinica de Cirugia General y Digestiva, Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+ Ocana, Luis. Unidad de Gestion Clinica de Cirugia General y Digestiva, Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+ El Azzouzi, Hamid. Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, 3436 HR, Netherlands.
+ Tinahones, Francisco J. Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+ Tinahones, Francisco J. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 29010, Malaga, Spain.
+ Tinahones, Francisco J. Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, 29010, Malaga, Spain.
+ Valdivielso, Pedro. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 29010, Malaga, Spain.
+ Valdivielso, Pedro. Centro de Investigaciones Medico-Sanitarias, CIMES, UGC de Medicina Interna, Hospital Universitario Virgen de la Victoria, 29010, Malaga, Spain.
+ Murri, Mora. Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Clinico Virgen de la Victoria, 29010, Malaga, Spain.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ DNA, Mitochondrial
+ Homeostasis
+ Humans
+ Hypertriglyceridemia/co [Complications]
+ Hypertriglyceridemia/ge [Genetics]
+ Hypertriglyceridemia/me [Metabolism]
+ *Hypertriglyceridemia
+ Intra-Abdominal Fat/me [Metabolism]
+ Mitochondria/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/su [Surgery]
+ *Obesity
+ Subcutaneous Fat/me [Metabolism]
+Keyword Heading
+ hypertriglyceridemia
+ metabolism
+ mitochondrial fitness
+ mitophagy
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: The prevalence of obesity and hypertriglyceridemia is an alarming worldwide health issue. Mitochondria play a central role in these disorders as they control cell metabolism.
+
+ OBJECTIVE: The aim of the present study was to characterize mitochondrial homeostasis in subcutaneous and visceral adipose tissue (SAT and VAT) in grade III obese patients with and without hypertriglyceridemia. Moreover, this study presents the evaluation of mitochondrial fitness as a marker for hypertriglyceridemia improvement.
+
+ PATIENTS: Eight control and 12 hypertriglyceridemic (HTG) grade III obese subjects undergoing bariatric surgery were included.
+
+ MAIN OUTCOME MEASURES: Anthropometric and biochemical data were obtained before and 3 months after surgery. Mitochondrial homeostasis was evaluated by mitochondrial DNA (mtDNA), gene expression and protein abundance in SAT and VAT.
+
+ RESULTS: Mitophagy-related gene expression was increased in HTG SAT and VAT, while mitochondrial marker gene expression and mtDNA were decreased, indicating an altered mitochondrial homeostasis in HTG. Mitophagy protein abundance was increased in VAT of those subjects that did not improve their levels of triglycerides after bariatric surgery, whereas mitochondrial protein was decreased in the same tissue. Indeed, triglyceride levels positively correlated with mitophagy-related genes and negatively with mitochondrial content markers. Moreover, mitochondria content and mitophagy markers seem to be significant predictors of hypertriglyceridemia and hypertriglyceridemia remission.
+
+ CONCLUSIONS: Mitochondrial homeostasis of adipose tissue is altered in hypertriglyceridemic patients. At the protein level, mitochondria content and mitophagy are potential markers of hypertriglyceridemia remission in obese patients after bariatric surgery. These results may contribute to the implementation of a clinical approach for personalized medicine. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (DNA, Mitochondrial).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1210%2fclinem%2fdgac332
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mela&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Mitochondrial+Homeostasis+in+Obesity-related+Hypertriglyceridemia.&volume=107&issue=8&spage=2203&epage=2215&date=2022&doi=10.1210%2Fclinem%2Fdgac332&pmid=35608825&sid=OVID:medline
+
+<493>
+Unique Identifier
+ 35606786
+Title
+ Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers.
+Source
+ Arthritis Research & Therapy. 24(1):120, 2022 05 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tardif G; Pare F; Gotti C; Roux-Dalvai F; Droit A; Zhai G; Sun G; Fahmi H; Pelletier JP; Martel-Pelletier J
+Author NameID
+ Martel-Pelletier, Johanne; ORCID: https://orcid.org/0000-0003-2618-383X
+Authors Full Name
+ Tardif, Ginette; Pare, Frederic; Gotti, Clarisse; Roux-Dalvai, Florence; Droit, Arnaud; Zhai, Guangju; Sun, Guang; Fahmi, Hassan; Pelletier, Jean-Pierre; Martel-Pelletier, Johanne.
+Institution
+ Tardif, Ginette. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Suite R11.412B, Montreal, QC, H2X 0A9, Canada.
+ Pare, Frederic. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Suite R11.412B, Montreal, QC, H2X 0A9, Canada.
+ Gotti, Clarisse. CHU de Quebec Research Center, Laval University, Quebec, QC, G1V 4G2, Canada.
+ Roux-Dalvai, Florence. CHU de Quebec Research Center, Laval University, Quebec, QC, G1V 4G2, Canada.
+ Droit, Arnaud. CHU de Quebec Research Center, Laval University, Quebec, QC, G1V 4G2, Canada.
+ Zhai, Guangju. Division of Biomedical Sciences (Genetics), Memorial University of Newfoundland, St. John's, NL, A1B 3V6, Canada.
+ Sun, Guang. Discipline of Medicine, Memorial University of Newfoundland, St. John's, NL, A1B 3V6, Canada.
+ Fahmi, Hassan. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Suite R11.412B, Montreal, QC, H2X 0A9, Canada.
+ Pelletier, Jean-Pierre. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Suite R11.412B, Montreal, QC, H2X 0A9, Canada.
+ Martel-Pelletier, Johanne. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Suite R11.412B, Montreal, QC, H2X 0A9, Canada. jm@martelpelletier.ca.
+MeSH Subject Headings
+ Biomarkers
+ Calcium-Binding Proteins
+ Humans
+ Mass Spectrometry/mt [Methods]
+ Obesity
+ Osteoarthritis/di [Diagnosis]
+ Osteoarthritis/me [Metabolism]
+ *Osteoarthritis
+ *Proteomics
+Keyword Heading
+ Mass spectrometry
+ Osteoarthritis
+ Proteomics
+ Serum biomarkers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection. To improve therapeutic approaches, identification of specific molecules/biomarkers enabling early determination of this disease is needed. This study aimed at identifying, with the use of proteomics/mass spectrometry, novel OA-specific serum biomarkers. As obesity is a major risk factor for OA, we discriminated obesity-regulated proteins to target only OA-specific proteins as biomarkers.
+
+ METHODS: Serum from the Osteoarthritis Initiative cohort was used and divided into 3 groups: controls (n=8), OA-obese (n=10) and OA-non-obese (n=10). Proteins were identified and quantified from the liquid chromatography-tandem mass spectrometry analyses using MaxQuant software. Statistical analysis used the Limma test followed by the Benjamini-Hochberg method. To compare the proteomic profiles, the multivariate unsupervised principal component analysis (PCA) followed by the pairwise comparison was used. To select the most predictive/discriminative features, the supervised linear classification model sparse partial least squares regression discriminant analysis (sPLS-DA) was employed. Validation of three differential proteins was performed with protein-specific assays using plasma from a cohort derived from the Newfoundland Osteoarthritis.
+
+ RESULTS: In total, 509 proteins were identified, and 279 proteins were quantified. PCA-pairwise differential comparisons between the 3 groups revealed that 8 proteins were differentially regulated between the OA-obese and/or OA-non-obese with controls. Further experiments using the sPLS-DA revealed two components discriminating OA from controls (component 1, 9 proteins), and OA-obese from OA-non-obese (component 2, 23 proteins). Proteins from component 2 were considered related to obesity. In component 1, compared to controls, 7 proteins were significantly upregulated by both OA groups and 2 by the OA-obese. Among upregulated proteins from both OA groups, some of them alone would not be a suitable choice as specific OA biomarkers due to their rather non-specific role or their strong link to other pathological conditions. Altogether, data revealed that the protein CRTAC1 appears to be a strong OA biomarker candidate. Other potential new biomarker candidates are the proteins FBN1, VDBP, and possibly SERPINF1. Validation experiments revealed statistical differences between controls and OA for FBN1 (p=0.044) and VDPB (p=0.022), and a trend for SERPINF1 (p=0.064).
+
+ CONCLUSION: Our study suggests that 4 proteins, CRTAC1, FBN1, VDBP, and possibly SERPINF1, warrant further investigation as potential new biomarker candidates for the whole OA population. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CRTAC1 protein, human). 0 (Calcium-Binding Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs13075-022-02801-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tardif&issn=1478-6354&title=Arthritis+Research+%26+Therapy&atitle=Mass+spectrometry-based+proteomics+identify+novel+serum+osteoarthritis+biomarkers.&volume=24&issue=1&spage=120&epage=&date=2022&doi=10.1186%2Fs13075-022-02801-1&pmid=35606786&sid=OVID:medline
+
+<494>
+Unique Identifier
+ 35592778
+Title
+ Higher Serum Soluble TREM2 as a Potential Indicative Biomarker for Cognitive Impairment in Inadequately Controlled Type 2 Diabetes Without Obesity: The DOR-KyotoJ-1.
+Source
+ Frontiers in Endocrinology. 13:880148, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tanaka M; Yamakage H; Muranaka K; Yamada T; Araki R; Ogo A; Matoba Y; Watanabe T; Saito M; Kurita S; Yonezawa K; Tanaka T; Suzuki M; Sawamura M; Matsumoto M; Nishimura M; Kusakabe T; Wada H; Hasegawa K; Kotani K; Noda M; Satoh-Asahara N
+Authors Full Name
+ Tanaka, Masashi; Yamakage, Hajime; Muranaka, Kazuya; Yamada, Tsutomu; Araki, Rika; Ogo, Atsushi; Matoba, Yuka; Watanabe, Tetsuhiro; Saito, Miho; Kurita, Seiichiro; Yonezawa, Kazuya; Tanaka, Tsuyoshi; Suzuki, Masahiro; Sawamura, Morio; Matsumoto, Morio; Nishimura, Motonobu; Kusakabe, Toru; Wada, Hiromichi; Hasegawa, Koji; Kotani, Kazuhiko; Noda, Mitsuhiko; Satoh-Asahara, Noriko.
+Institution
+ Tanaka, Masashi. Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
+ Tanaka, Masashi. Department of Physical Therapy, Health Science University, Yamanashi, Japan.
+ Yamakage, Hajime. Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
+ Muranaka, Kazuya. Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
+ Yamada, Tsutomu. Department of Endocrinology and Diabetes, National Hospital Organization Nagoya Medical Center, Aichi, Japan.
+ Araki, Rika. Department of Diabetes and Endocrinology, National Hospital Organization National Mie Hospital, Mie, Japan.
+ Ogo, Atsushi. Department of Metabolism and Endocrinology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
+ Matoba, Yuka. Department of Metabolism and Endocrinology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
+ Watanabe, Tetsuhiro. Department of Metabolism and Endocrinology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
+ Saito, Miho. Department of Internal Medicine, Tokushima National Hospital, Tokushima, Japan.
+ Kurita, Seiichiro. Department of Internal Medicine, National Hospital Organization Kanazawa Medical Center, Ishikawa, Japan.
+ Yonezawa, Kazuya. Department of Clinical Research, Hakodate National Hospital, Hokkaido, Japan.
+ Tanaka, Tsuyoshi. Department of Endocrinology and Metabolism, National Hospital Organization Mie Chuo Medical Center, Mie, Japan.
+ Suzuki, Masahiro. Department of Clinical Research, National Hospital Organization Saitama Hospital, Saitama, Japan.
+ Sawamura, Morio. Department of Hematology, National Hospital Organization Shibukawa Medical Center, Gunma, Japan.
+ Matsumoto, Morio. Department of Hematology, National Hospital Organization Shibukawa Medical Center, Gunma, Japan.
+ Nishimura, Motonobu. Department of Diabetes and Endocrinology, National Hospital Organization Chibahigashi National Hospital, Chiba, Japan.
+ Kusakabe, Toru. Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
+ Wada, Hiromichi. Division of Translational Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
+ Hasegawa, Koji. Division of Translational Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
+ Kotani, Kazuhiko. Center for Community Medicine, Jichi Medical University, Tochigi, Japan.
+ Noda, Mitsuhiko. Department of Diabetes, Metabolism and Endocrinology, Ichikawa Hospital, International University of Health and Welfare, Chiba, Japan.
+ Noda, Mitsuhiko. Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan.
+ Satoh-Asahara, Noriko. Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
+ Satoh-Asahara, Noriko. Department of Metabolic Syndrome and Nutritional Science, Research Institute of Environmental Medicine, Nagoya University, Aichi, Japan.
+MeSH Subject Headings
+ Biomarkers
+ Cognitive Dysfunction/di [Diagnosis]
+ Cognitive Dysfunction/et [Etiology]
+ Cognitive Dysfunction/me [Metabolism]
+ *Cognitive Dysfunction
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Humans
+ Membrane Glycoproteins/me [Metabolism]
+ Myeloid Cells
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Receptors, Immunologic/me [Metabolism]
+Keyword Heading
+ cognitive impairment (CI)
+ glycemic control
+ longitudinal cohort study
+ serum soluble TREM2
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: Type 2 diabetes is a risk factor for dementia. We investigated whether serum levels of soluble triggering receptor expressed on myeloid cell 2 (sTREM2), a soluble form of the cell surface receptor TREM2, were predictive of cognitive impairment in type 2 diabetes without obesity.
+
+ Methods: A total of 166 Japanese patients with type 2 diabetes without obesity were followed-up for 2 years. We measured clinical parameters, assessed cognitive function using the mini-mental state examination (MMSE), quantified and divided serum sTREM2 levels into quartiles, and examined the longitudinal associations.
+
+ Results: During the follow-up, HbA1c levels were elevated in 98 patients and decreased in 68 patients. In the HbA1c-elevated group, higher sTREM2 levels at baseline showed a significant association with a greater tendency for reduction in MMSE scores (P for trend = 0.015), whereas they were not significantly associated with other examined parameters. In the HbA1c-decreased group, there was no significant association between sTREM2 levels at baseline and changes in MMSE scores, but higher sTREM2 levels at baseline were significantly associated with a greater tendency for reduction in waist circumference (P for trend = 0.027), homeostasis model assessment of insulin resistance (P for trend = 0.039), and sTREM2 levels (P for trend = 0.023).
+
+ Conclusions: Glycemic control is suggested to be important in preventing cognitive impairment in patients with type 2 diabetes without obesity. Higher serum sTREM2 levels would be a predictive marker for cognitive impairment in inadequately controlled type 2 diabetes without obesity. Copyright © 2022 Tanaka, Yamakage, Muranaka, Yamada, Araki, Ogo, Matoba, Watanabe, Saito, Kurita, Yonezawa, Tanaka, Suzuki, Sawamura, Matsumoto, Nishimura, Kusakabe, Wada, Hasegawa, Kotani, Noda and Satoh-Asahara.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Membrane Glycoproteins). 0 (Receptors, Immunologic). 0 (TREM2 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.880148
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tanaka&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Higher+Serum+Soluble+TREM2+as+a+Potential+Indicative+Biomarker+for+Cognitive+Impairment+in+Inadequately+Controlled+Type+2+Diabetes+Without+Obesity%3A+The+DOR-KyotoJ-1.&volume=13&issue=&spage=880148&epage=&date=2022&doi=10.3389%2Ffendo.2022.880148&pmid=35592778&sid=OVID:medline
+
+<495>
+Unique Identifier
+ 35591766
+Title
+ Inhalation of low-dose basil (Ocimum basilicum) essential oil improved cardiovascular health and plasma lipid markers in high fat diet-induced obese rats.
+Source
+ Journal of Food Science. 87(6):2450-2462, 2022 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hong SJ; Kim DS; Lee J; Boo CG; Youn MY; Le B; Kim JK; Shin EC
+Author NameID
+ Shin, Eui-Cheol; ORCID: https://orcid.org/0000-0003-4243-4643
+Authors Full Name
+ Hong, Seong Jun; Kim, Da-Som; Lee, Jookyeong; Boo, Chang Guk; Youn, Moon Yeon; Le, Brandy; Kim, Jae Kyeom; Shin, Eui-Cheol.
+Institution
+ Hong, Seong Jun. Department of Food Science/GreenBio Science, Gyeongsang National University, Jinju, Republic of Korea.
+ Kim, Da-Som. Department of Food Science/GreenBio Science, Gyeongsang National University, Jinju, Republic of Korea.
+ Lee, Jookyeong. Faculty of Health, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia.
+ Boo, Chang Guk. Department of Food Science/GreenBio Science, Gyeongsang National University, Jinju, Republic of Korea.
+ Youn, Moon Yeon. Department of Food Science/GreenBio Science, Gyeongsang National University, Jinju, Republic of Korea.
+ Le, Brandy. Department of Behavioral Health and Nutrition, University of Delaware, Newark, Delaware, USA.
+ Kim, Jae Kyeom. Department of Behavioral Health and Nutrition, University of Delaware, Newark, Delaware, USA.
+ Shin, Eui-Cheol. Department of Food Science/GreenBio Science, Gyeongsang National University, Jinju, Republic of Korea.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat
+ Leptin/me [Metabolism]
+ Leptin/pd [Pharmacology]
+ Obesity/dt [Drug Therapy]
+ *Ocimum
+ Ocimum basilicum/ch [Chemistry]
+ *Ocimum basilicum
+ Oils, Volatile/ch [Chemistry]
+ Oils, Volatile/pd [Pharmacology]
+ *Oils, Volatile
+ Plant Oils/ch [Chemistry]
+ Rats
+Keyword Heading
+ antiobesity
+ basil (Ocimum basilicum) essential oil
+ blood pressure
+ inhalation
+ leptin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study investigated the antiobesogenic effects of the inhalation of volatile compounds derived from basil essential oil (BEO) in high fat diet-induced obese rats. A total of 47 volatile compounds were identified in BEO using gas chromatography-mass spectrometry. Major volatile compounds identified by olfactory testing include linalool oxide, linalool, 1-menthene, and carvone. White adipose tissue significantly decreased in the rats that inhaled 0.3% BEO (more than +10%) compared to the control. Plasma marker analysis showed increased high-density lipoprotein-cholesterol (ca. double fold) and decreased low-density lipoprotein-cholesterol (more than -30%) levels in inhaled 1% BEO group compared to the control. Leptin significantly decreased in the 0.3 and 1% BEO groups (more than -70 and -85%, respectively). Last, systolic blood pressure at week 12 was significantly lower in inhaled 1% BEO group (more than -15%) compared to the control. The results of this study suggest that BEO inhalation may be effective in managing plasma lipid markers (cholesterols and leptin) and possibly metabolic disorders such as obesity. Practical Application: Changes in metabolic health markers, which are effected by inhalation of volatiles in basil (Ocimum basilicum) essential oil, will provide physiological variations in vivo to the public. In this study, the opposite effects were identified between 0.3% and 1% inhalation, respectively. Therefore, our findings will provide optimized and useful guidance for inhalation of basil essential oil. Copyright © 2022 Institute of Food Technologists R.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). 0 (Oils, Volatile). 0 (Plant Oils).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1111%2f1750-3841.16196
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hong&issn=0022-1147&title=Journal+of+Food+Science&atitle=Inhalation+of+low-dose+basil+%28Ocimum+basilicum%29+essential+oil+improved+cardiovascular+health+and+plasma+lipid+markers+in+high+fat+diet-induced+obese+rats.&volume=87&issue=6&spage=2450&epage=2462&date=2022&doi=10.1111%2F1750-3841.16196&pmid=35591766&sid=OVID:medline
+
+<496>
+Unique Identifier
+ 35587078
+Title
+ Effect of laser biostimulation and a low-calorie diet vs. a low-calorie diet alone on insulin resistance, inflammatory biomarkers, and depression among obese postmenopausal women: a randomized controlled trial.
+Source
+ European Review for Medical & Pharmacological Sciences. 26(9):3269-3277, 2022 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elsayed MM; Rakha M; Elsheimy HA; Abdelaziz NE; Nagy EN
+Authors Full Name
+ Elsayed, M M; Rakha, M; Elsheimy, H A; Abdelaziz, N E; Nagy, E N.
+Institution
+ Elsayed, M M. Department of Physical Therapy for Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Cairo University, Cairo, Egypt. Marwa.elsaid@cu.edu.eg.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Body Mass Index
+ Caloric Restriction
+ Depression
+ Diet, Reducing
+ Female
+ Humans
+ *Insulin Resistance
+ *Low-Level Light Therapy
+ Middle Aged
+ Obesity
+ Postmenopause
+ Weight Loss
+Abstract
+ OBJECTIVE: Postmenopausal women are significantly predisposed to a multitude of disorders. Laser biostimulation (LB) and a healthy diet have been linked to multiple health benefits. This study aimed to investigate the effect of a combined LB and balanced low-calorie diet (LCD) vs. an LCD alone on insulin resistance (IR), inflammatory biomarkers, and depression score in obese postmenopausal women.
+
+ PATIENTS AND METHODS: In the present study, a total of 66 postmenopausal women, with a mean age of 66.61 +/- 4.80 years and a body mass index (BMI) of 35.93 +/- 2.67 kg/m2, were randomized into two equal groups. The experimental group received LB and LCD (including 50-60% carbohydrates, 15-20% protein, 20-35% fat, and 25 g of fiber/day plus a restriction of 500-1000 kcal/d), while the control group followed the same diet program only for 12 weeks. Before and after the intervention, IR [measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR index)], inflammatory biomarkers [C-reactive protein (CRP), white blood cells (WBCs), lymphocytes, and erythrocyte sedimentation rate (ESR)], and depression level [as assessed by the Hamilton Depression Rating Scale (HAMD-17)] were all measured.
+
+ RESULTS: Using an intention-to-treat analysis for 60 women who completed the study, the body weight average reduction was -13.14% for the experimental group (p<0.001) vs. -6.36% for the control group (p<0.001). BMI, IR, inflammatory markers, and depression levels were also similarly changed.
+
+ CONCLUSIONS: In postmenopausal obese women, adding LB to a suitable dietary program provides the most significant benefit in terms of lowering IR, metabolic inflammation, and depression.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.26355%2feurrev_202205_28745
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elsayed&issn=1128-3602&title=European+Review+for+Medical+%26+Pharmacological+Sciences&atitle=Effect+of+laser+biostimulation+and+a+low-calorie+diet+vs.+a+low-calorie+diet+alone+on+insulin+resistance%2C+inflammatory+biomarkers%2C+and+depression+among+obese+postmenopausal+women%3A+a+randomized+controlled+trial.&volume=26&issue=9&spage=3269&epage=3277&date=2022&doi=10.26355%2Feurrev_202205_28745&pmid=35587078&sid=OVID:medline
+
+<497>
+Unique Identifier
+ 35586621
+Title
+ Positive Effects of Extra-Virgin Olive Oil Supplementation and DietBra on Inflammation and Glycemic Profiles in Adults With Type 2 Diabetes and Class II/III Obesity: A Randomized Clinical Trial.
+Source
+ Frontiers in Endocrinology. 13:841971, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Silveira EA; Rosa LPS; de Resende DP; Rodrigues APDS; da Costa AC; Rezende ATO; Noll M; de Oliveira C; Junqueira-Kipnis AP
+Authors Full Name
+ Silveira, Erika Aparecida; Rosa, Lorena Pereira de Souza; de Resende, Danilo Pires; Rodrigues, Ana Paula Dos Santos; da Costa, Adeliane Castro; Rezende, Andrea Toledo de Oliveira; Noll, Matias; de Oliveira, Cesar; Junqueira-Kipnis, Ana Paula.
+Institution
+ Silveira, Erika Aparecida. Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goias, Goias, Brazil.
+ Silveira, Erika Aparecida. Department of Epidemiology and Public Health, University College London, London, United Kingdom.
+ Rosa, Lorena Pereira de Souza. Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goias, Goias, Brazil.
+ Rosa, Lorena Pereira de Souza. Federal Institute of Goias, Campus Goiania, Goias, Brazil.
+ de Resende, Danilo Pires. Department of Biosciences, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goias, Brazil.
+ Rodrigues, Ana Paula Dos Santos. Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goias, Goias, Brazil.
+ da Costa, Adeliane Castro. Department of Biosciences, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goias, Brazil.
+ Rezende, Andrea Toledo de Oliveira. Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goias, Goias, Brazil.
+ Noll, Matias. Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goias, Goias, Brazil.
+ Noll, Matias. Instituto Federal Goiano, Campus Ceres, Goias, Brazil.
+ de Oliveira, Cesar. Department of Epidemiology and Public Health, University College London, London, United Kingdom.
+ Junqueira-Kipnis, Ana Paula. Department of Biosciences, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goias, Brazil.
+MeSH Subject Headings
+ Adiponectin
+ Adult
+ Biomarkers
+ Blood Glucose
+ *Diabetes Mellitus, Type 2
+ Dietary Supplements
+ Humans
+ Inflammation
+ Insulin
+ Obesity/co [Complications]
+ Olive Oil
+Keyword Heading
+ IL-1alpha
+ TNFalpha
+ adiponectin
+ diabetes
+ fasting insulin
+ inflammatory response
+ interleukin
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Evidence on the effects of dietary interventions on inflammatory markers in individuals with obesity and type 2 diabetes mellitus (T2DM) is scarce. Our study evaluated the effects of extra-virgin olive oil alone and in combination with a traditional Brazilian diet on inflammatory markers and glycemic profiles in adults with both T2DM and class II/III obesity.
+
+ Methods: Adults aged 18-64 years with T2DM and class II/III obesity were randomized into two intervention groups: 1) extra-virgin olive oil only and 2) extra-virgin olive oil + a traditional Brazilian diet (OliveOil+DietBra). Data on sociodemographic characteristics, lifestyle, anthropometry, biochemical markers and inflammatory markers were collected. The primary outcomes were glycemic parameters and inflammatory markers. The body mass index (BMI) and weight were the secondary outcomes.
+
+ Results: Forty individuals with T2DM and class II/III obesity were enrolled, and 34 (85%) completed the intervention course. The intake of olive oil was 37.88 +/- 12.50 mL/day in the olive oil group and 37.71 +/- 12.23 mL/day in the OliveOil+DietBra group, with no significant difference between groups (p = 0.484). Compared to the olive oil only group, the OliveOil+DietBra group had significantly lower levels of fasting insulin (p = 0.047) at the end of the intervention, whereas the other glycemic parameters were not altered. In the OliveOil+DietBra group, serum levels of inflammatory cytokines, IL-1alpha (p = 0.006) and adiponectin (p = 0.049) were lower and those of TNFalpha were higher (p = 0.037). There was a significant reduction in BMI and weight compared to the baseline values in the OliveOil+DietBra group (p = 0.015).
+
+ Conclusions: The intervention with OliveOil+DietBra effectively decreased the levels of fasting insulin, IL-1alpha and adiponectin, suggesting its beneficial role in improving the inflammatory profiles and fasting insulin levels in adults with class II/III obesity and T2DM.
+
+ Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT02463435. Copyright © 2022 Silveira, Rosa, de Resende, Rodrigues, da Costa, Rezende, Noll, de Oliveira and Junqueira-Kipnis.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Olive Oil).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.841971
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Silveira&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Positive+Effects+of+Extra-Virgin+Olive+Oil+Supplementation+and+DietBra+on+Inflammation+and+Glycemic+Profiles+in+Adults+With+Type+2+Diabetes+and+Class+II%2FIII+Obesity%3A+A+Randomized+Clinical+Trial.&volume=13&issue=&spage=841971&epage=&date=2022&doi=10.3389%2Ffendo.2022.841971&pmid=35586621&sid=OVID:medline
+
+<498>
+Unique Identifier
+ 35576873
+Title
+ The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial.
+Source
+ Nutrition. 99-100:111674, 2022 Jul-Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cheung MM; Dall RD; Shewokis PA; Altasan A; Volpe SL; Amori R; Singh H; Sukumar D
+Authors Full Name
+ Cheung, May M; Dall, Rosemary D; Shewokis, Patricia A; Altasan, Asma; Volpe, Stella L; Amori, Renee; Singh, Harpreet; Sukumar, Deeptha.
+Institution
+ Cheung, May M. Monell Chemical Senses Center, Philadelphia, Pennsylvania.
+ Dall, Rosemary D. Envision Pharma Group, Philadelphia, Pennsylvania.
+ Shewokis, Patricia A. Department of Nutrition Sciences, Drexel University, Philadelphia, Pennsylvania.
+ Altasan, Asma. Department of Clinical Nutrition, King Saud bin Abdulaziz University for Health Science, Riyadh, Saudi Arabia.
+ Volpe, Stella L. Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
+ Amori, Renee. St. Luke's University Health Network, Fountain Hill, Pennsylvania.
+ Singh, Harpreet. Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio.
+ Sukumar, Deeptha. Department of Nutrition Sciences, Drexel University, Philadelphia, Pennsylvania. Electronic address: deeptha.sukumar@drexel.edu.
+MeSH Subject Headings
+ Biomarkers
+ Blood Pressure
+ Cholecalciferol/pd [Pharmacology]
+ Cholecalciferol/tu [Therapeutic Use]
+ Dietary Supplements
+ Humans
+ Inflammation/dt [Drug Therapy]
+ Magnesium/tu [Therapeutic Use]
+ *Magnesium
+ Obesity
+ Overweight
+ Parathyroid Hormone
+ Vitamin D
+ Vitamin D Deficiency/dt [Drug Therapy]
+ *Vitamin D Deficiency
+ Vitamins/pd [Pharmacology]
+ Vitamins/tu [Therapeutic Use]
+Keyword Heading
+ Blood pressure
+ Cardiovascular health
+ Magnesium
+ Parathyroid hormone
+ Systemic inflammation
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Poor vitamin D and magnesium status is observed in individuals who are overweight and obese (Owt/Ob) and is often associated with a heightened risk of cardiovascular disease. Magnesium is a cofactor that assists vitamin D metabolism. We aimed to determine the efficacy of a combined magnesium and vitamin D regimen compared with vitamin D only on increasing serum 25-hydroxyvitamin D (25OHD) concentrations and the effects of these supplements on cardiometabolic outcomes.
+
+ METHODS: This 12-week double-blinded randomized controlled trial had three treatment arms: magnesium + vitamin D (MagD; 360 mg magnesium glycinate + 1000 IU vitamin D 3 x daily), vitamin D only (VitD; 1000 IU vitamin D 3 x daily), and placebo. A total of 95 Owt/Ob participants were randomized into one of these three study arms. Anthropometry, dietary intake, concentrations of serum 25OHD, serum parathyroid hormone (PTH), serum inflammatory markers, and blood pressure were obtained at baseline and week 12.
+
+ RESULTS: The MagD group experienced the greatest increase in serum 25OHD concentrations (6.3 +/- 8.36 ng/mL; P < 0.05). There was a decrease in systolic blood pressure (7.5 +/- 8.26 mmHg; P < 0.05) for individuals who had a baseline systolic blood pressure of >132 mmHg in the MagD group. There were no statistically significant treatment effects on serum PTH concentrations and markers of inflammation.
+
+ CONCLUSIONS: A combined MagD treatment may be more effective in increasing serum 25OHD concentrations compared with VitD supplementation alone in Owt/Ob individuals. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Parathyroid Hormone). 0 (Vitamins). 1406-16-2 (Vitamin D). 1C6V77QF41 (Cholecalciferol). I38ZP9992A (Magnesium).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1016%2fj.nut.2022.111674
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cheung&issn=0899-9007&title=Nutrition&atitle=The+effect+of+combined+magnesium+and+vitamin+D+supplementation+on+vitamin+D+status%2C+systemic+inflammation%2C+and+blood+pressure%3A+A+randomized+double-blinded+controlled+trial.&volume=99-100&issue=&spage=111674&epage=&date=2022&doi=10.1016%2Fj.nut.2022.111674&pmid=35576873&sid=OVID:medline
+
+<499>
+Unique Identifier
+ 35563854
+Title
+ The Relationship between Obesity and Pre-Eclampsia: Incidental Risks and Identification of Potential Biomarkers for Pre-Eclampsia. [Review]
+Source
+ Cells. 11(9), 2022 05 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abraham T; Romani AMP
+Authors Full Name
+ Abraham, Talitha; Romani, Andrea M P.
+Institution
+ Abraham, Talitha. Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA.
+ Romani, Andrea M P. Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA.
+MeSH Subject Headings
+ Biomarkers
+ *Diabetes, Gestational
+ *Eclampsia
+ Female
+ Humans
+ Obesity/co [Complications]
+ *Pre-Eclampsia
+ Pregnancy
+ United States
+Keyword Heading
+ ROS
+ adipokines
+ adiponectin
+ angiogenic factors
+ biomarkers
+ leptin
+ obesity
+ pre-eclampsia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity has been steadily increasing over the past decade in the US and worldwide. Since 1975, the prevalence of obesity has increased by 2% per decade, unabated despite new and more stringent guidelines set by WHO, CDC, and other public health organizations. Likewise, maternal obesity has also increased worldwide over the past several years. In the United States, pre-pregnancy rates have increased proportionally across all racial groups. Obesity during pregnancy has been directly linked to obstetric complications including gestational diabetes, HTN, hematomas, pre-eclampsia, and congenital defects. In the particular case of pre-eclampsia, the incidence rate across the globe is 2.16%, but the condition accounts for 30% of maternal deaths, and a robust body of evidence underscored the relationship between obesity and pre-eclampsia. More recently, attention has focused on the identification of reliable biomarkers predictive of an elevated risk for pre-eclampsia. The aim of this literature review is to elucidate the relationship between obesity and these predictive biomarkers for future prediction and prevention of pre-eclampsia condition in women at risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fcells11091548
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abraham&issn=2073-4409&title=Cells&atitle=The+Relationship+between+Obesity+and+Pre-Eclampsia%3A+Incidental+Risks+and+Identification+of+Potential+Biomarkers+for+Pre-Eclampsia.&volume=11&issue=9&spage=&epage=&date=2022&doi=10.3390%2Fcells11091548&pmid=35563854&sid=OVID:medline
+
+<500>
+Unique Identifier
+ 35563473
+Title
+ Machine Learning and Pathway Analysis-Based Discovery of Metabolomic Markers Relating to Chronic Pain Phenotypes.
+Source
+ International Journal of Molecular Sciences. 23(9), 2022 May 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Miettinen T; Nieminen AI; Mantyselka P; Kalso E; Lotsch J
+Author NameID
+ Miettinen, Teemu; ORCID: https://orcid.org/0000-0003-3504-4663
+ Nieminen, Anni I; ORCID: https://orcid.org/0000-0001-8999-6040
+ Kalso, Eija; ORCID: https://orcid.org/0000-0002-4899-605X
+ Lotsch, Jorn; ORCID: https://orcid.org/0000-0002-5818-6958
+Authors Full Name
+ Miettinen, Teemu; Nieminen, Anni I; Mantyselka, Pekka; Kalso, Eija; Lotsch, Jorn.
+Institution
+ Miettinen, Teemu. Pain Clinic, Department of Perioperative Medicine, Intensive Care and Pain Medicine, Helsinki University Hospital and SleepWell Research Programme, University of Helsinki, 00014 Helsinki, Finland.
+ Nieminen, Anni I. Metabolomics Unit, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
+ Mantyselka, Pekka. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Finland, and Primary Health Care Unit, Kuopio University Hospital, 70211 Kuopio, Finland.
+ Kalso, Eija. Pain Clinic, Department of Perioperative Medicine, Intensive Care and Pain Medicine, Helsinki University Hospital and SleepWell Research Programme, University of Helsinki, 00014 Helsinki, Finland.
+ Lotsch, Jorn. Institute of Clinical Pharmacology, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
+ Lotsch, Jorn. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
+MeSH Subject Headings
+ Adenosine Monophosphate/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Chronic Pain/ge [Genetics]
+ Chronic Pain/me [Metabolism]
+ *Chronic Pain
+ Cysteine/me [Metabolism]
+ Female
+ Humans
+ Machine Learning
+ *Metabolome
+ Metabolomics/mt [Methods]
+ Methionine/me [Metabolism]
+ NAD/me [Metabolism]
+ Obesity/me [Metabolism]
+ Phenotype
+ Sleep Wake Disorders
+Keyword Heading
+ chronic pain phenotypes
+ metabolic markers
+ metabolic pathways
+ obesity
+ sleep disorders
+ supervised machine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Recent scientific evidence suggests that chronic pain phenotypes are reflected in metabolomic changes. However, problems associated with chronic pain, such as sleep disorders or obesity, may complicate the metabolome pattern. Such a complex phenotype was investigated to identify common metabolomics markers at the interface of persistent pain, sleep, and obesity in 71 men and 122 women undergoing tertiary pain care. They were examined for patterns in d = 97 metabolomic markers that segregated patients with a relatively benign pain phenotype (low and little bothersome pain) from those with more severe clinical symptoms (high pain intensity, more bothersome pain, and co-occurring problems such as sleep disturbance). Two independent lines of data analysis were pursued. First, a data-driven supervised machine learning-based approach was used to identify the most informative metabolic markers for complex phenotype assignment. This pointed primarily at adenosine monophosphate (AMP), asparagine, deoxycytidine, glucuronic acid, and propionylcarnitine, and secondarily at cysteine and nicotinamide adenine dinucleotide (NAD) as informative for assigning patients to clinical pain phenotypes. After this, a hypothesis-driven analysis of metabolic pathways was performed, including sleep and obesity. In both the first and second line of analysis, three metabolic markers (NAD, AMP, and cysteine) were found to be relevant, including metabolic pathway analysis in obesity, associated with changes in amino acid metabolism, and sleep problems, associated with downregulated methionine metabolism. Taken together, present findings provide evidence that metabolomic changes associated with co-occurring problems may play a role in the development of severe pain. Co-occurring problems may influence each other at the metabolomic level. Because the methionine and glutathione metabolic pathways are physiologically linked, sleep problems appear to be associated with the first metabolic pathway, whereas obesity may be associated with the second.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0U46U6E8UK (NAD). 415SHH325A (Adenosine Monophosphate). AE28F7PNPL (Methionine). K848JZ4886 (Cysteine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms23095085
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Miettinen&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Machine+Learning+and+Pathway+Analysis-Based+Discovery+of+Metabolomic+Markers+Relating+to+Chronic+Pain+Phenotypes.&volume=23&issue=9&spage=5085&epage=&date=2022&doi=10.3390%2Fijms23095085&pmid=35563473&sid=OVID:medline
+
+<501>
+Unique Identifier
+ 35563210
+Title
+ Liver Steatosis: A Marker of Metabolic Risk in Children. [Review]
+Source
+ International Journal of Molecular Sciences. 23(9), 2022 Apr 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Neri CR; Scapaticci S; Chiarelli F; Giannini C
+Author NameID
+ Scapaticci, Serena; ORCID: https://orcid.org/0000-0002-2605-925X
+ Giannini, Cosimo; ORCID: https://orcid.org/0000-0002-2904-2744
+Authors Full Name
+ Neri, Costanza Renata; Scapaticci, Serena; Chiarelli, Francesco; Giannini, Cosimo.
+Institution
+ Neri, Costanza Renata. Department of Pediatrics, University of Chieti, Via dei Vestini, 5, 66100 Chieti, Italy.
+ Scapaticci, Serena. Department of Pediatrics, University of Chieti, Via dei Vestini, 5, 66100 Chieti, Italy.
+ Chiarelli, Francesco. Department of Pediatrics, University of Chieti, Via dei Vestini, 5, 66100 Chieti, Italy.
+ Giannini, Cosimo. Department of Pediatrics, University of Chieti, Via dei Vestini, 5, 66100 Chieti, Italy.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ Child
+ Humans
+ Liver/me [Metabolism]
+ Metabolic Syndrome/pa [Pathology]
+ *Metabolic Syndrome
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+Keyword Heading
+ Metabolic Syndrome (MetS) and children
+ NAFLD and children
+ NASH and children
+ hepatic fibrosis in children
+ pediatric MAFLD
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is one of the greatest health challenges affecting children of all ages and ethnicities. Almost 19% of children and adolescents worldwide are overweight or obese, with an upward trend in the last decades. These reports imply an increased risk of fat accumulation in hepatic cells leading to a series of histological hepatic damages gathered under the acronym NAFLD (Non-Alcoholic Fatty Liver Disease). Due to the complex dynamics underlying this condition, it has been recently renamed as 'Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)', supporting the hypothesis that hepatic steatosis is a key component of the large group of clinical and laboratory abnormalities of Metabolic Syndrome (MetS). This review aims to share the latest scientific knowledge on MAFLD in children in an attempt to offer novel insights into the complex dynamics underlying this condition, focusing on the novel molecular aspects. Although there is still no treatment with a proven efficacy for this condition, starting from the molecular basis of the disease, MAFLD's therapeutic landscape is rapidly expanding, and different medications seem to act as modifiers of liver steatosis, inflammation, and fibrosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms23094822
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Neri&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Liver+Steatosis%3A+A+Marker+of+Metabolic+Risk+in+Children.&volume=23&issue=9&spage=4822&epage=&date=2022&doi=10.3390%2Fijms23094822&pmid=35563210&sid=OVID:medline
+
+<502>
+Unique Identifier
+ 35562794
+Title
+ Elucidating the role of the gut microbiota in the physiological effects of dietary fiber.
+Source
+ Microbiome. 10(1):77, 2022 05 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Deehan EC; Zhang Z; Riva A; Armet AM; Perez-Munoz ME; Nguyen NK; Krysa JA; Seethaler B; Zhao YY; Cole J; Li F; Hausmann B; Spittler A; Nazare JA; Delzenne NM; Curtis JM; Wismer WV; Proctor SD; Bakal JA; Bischoff SC; Knights D; Field CJ; Berry D; Prado CM; Walter J
+Author NameID
+ Deehan, Edward C; ORCID: https://orcid.org/0000-0001-7697-1418
+ Zhang, Zhengxiao; ORCID: https://orcid.org/0000-0002-6977-4309
+ Walter, Jens; ORCID: https://orcid.org/0000-0003-1754-172X
+Authors Full Name
+ Deehan, Edward C; Zhang, Zhengxiao; Riva, Alessandra; Armet, Anissa M; Perez-Munoz, Maria Elisa; Nguyen, Nguyen K; Krysa, Jacqueline A; Seethaler, Benjamin; Zhao, Yuan-Yuan; Cole, Janis; Li, Fuyong; Hausmann, Bela; Spittler, Andreas; Nazare, Julie-Anne; Delzenne, Nathalie M; Curtis, Jonathan M; Wismer, Wendy V; Proctor, Spencer D; Bakal, Jeffrey A; Bischoff, Stephan C; Knights, Dan; Field, Catherine J; Berry, David; Prado, Carla M; Walter, Jens.
+Institution
+ Deehan, Edward C. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada. deehan@ualberta.ca.
+ Zhang, Zhengxiao. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
+ Zhang, Zhengxiao. College of Food and Biological Engineering, Jimei University, Xiamen, Fujian, China.
+ Riva, Alessandra. Department of Microbiology and Ecosystem Science, Division of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.
+ Armet, Anissa M. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Perez-Munoz, Maria Elisa. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Nguyen, Nguyen K. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Krysa, Jacqueline A. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Krysa, Jacqueline A. Metabolic and Cardiovascular Disease Laboratory, University of Alberta, Edmonton, Alberta, Canada.
+ Seethaler, Benjamin. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+ Zhao, Yuan-Yuan. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Cole, Janis. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Li, Fuyong. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Hausmann, Bela. Joint Microbiome Facility of the Medical University of Vienna and University of Vienna, Vienna, Austria.
+ Hausmann, Bela. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
+ Spittler, Andreas. Core Facility Flow Cytometry and Department of Surgery, Research Lab, Medical University of Vienna, Vienna, Austria.
+ Nazare, Julie-Anne. Centre de Recherche en Nutrition Humaine Rhone-Alpes, Univ-Lyon, CarMeN Laboratory, INSERM, INRA, INSA Lyon, Universite Claude Bernard Lyon 1, Hospices Civils de Lyon, F-CRIN/FORCE Network, Pierre-Benite, France.
+ Delzenne, Nathalie M. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium.
+ Curtis, Jonathan M. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Wismer, Wendy V. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Proctor, Spencer D. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Proctor, Spencer D. Metabolic and Cardiovascular Disease Laboratory, University of Alberta, Edmonton, Alberta, Canada.
+ Bakal, Jeffrey A. Patient Health Outcomes Research and Clinical Effectiveness Unit, Division of General Internal Medicine, University of Alberta, Edmonton, Alberta, Canada.
+ Bischoff, Stephan C. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+ Knights, Dan. Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
+ Knights, Dan. BioTechnology Institute, University of Minnesota, Saint Paul, Minnesota, USA.
+ Field, Catherine J. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Berry, David. Department of Microbiology and Ecosystem Science, Division of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.
+ Berry, David. Joint Microbiome Facility of the Medical University of Vienna and University of Vienna, Vienna, Austria.
+ Prado, Carla M. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
+ Walter, Jens. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada. jenswalter@ucc.ie.
+ Walter, Jens. Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada. jenswalter@ucc.ie.
+ Walter, Jens. APC Microbiome Ireland, School of Microbiology, and Department of Medicine, University College Cork - National University of Ireland, Cork, Ireland. jenswalter@ucc.ie.
+MeSH Subject Headings
+ Adult
+ Bacteria
+ Bile Acids and Salts/an [Analysis]
+ Biomarkers/an [Analysis]
+ Dietary Fiber
+ Feces/mi [Microbiology]
+ Female
+ Gastrointestinal Microbiome/ph [Physiology]
+ *Gastrointestinal Microbiome
+ Humans
+ Leukocyte L1 Antigen Complex/an [Analysis]
+ Leukocyte L1 Antigen Complex/pd [Pharmacology]
+ Male
+ Obesity/mi [Microbiology]
+Keyword Heading
+ Adults
+ Dietary fiber
+ Gut microbiota
+ Inflammation
+ Insulin resistance
+ Obesity
+ Satiety
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Dietary fiber is an integral part of a healthy diet, but questions remain about the mechanisms that underlie effects and the causal contributions of the gut microbiota. Here, we performed a 6-week exploratory trial in adults with excess weight (BMI: 25-35 kg/m2) to compare the effects of a high-dose (females: 25 g/day; males: 35 g/day) supplement of fermentable corn bran arabinoxylan (AX; n = 15) with that of microbiota-non-accessible microcrystalline cellulose (MCC; n = 16). Obesity-related surrogate endpoints and biomarkers of host-microbiome interactions implicated in the pathophysiology of obesity (trimethylamine N-oxide, gut hormones, cytokines, and measures of intestinal barrier integrity) were assessed. We then determined whether clinical outcomes could be predicted by fecal microbiota features or mechanistic biomarkers.
+
+ RESULTS: AX enhanced satiety after a meal and decreased homeostatic model assessment of insulin resistance (HOMA-IR), while MCC reduced tumor necrosis factor-alpha and fecal calprotectin. Machine learning models determined that effects on satiety could be predicted by fecal bacterial taxa that utilized AX, as identified by bioorthogonal non-canonical amino acid tagging. Reductions in HOMA-IR and calprotectin were associated with shifts in fecal bile acids, but correlations were negative, suggesting that the benefits of fiber may not be mediated by their effects on bile acid pools. Biomarkers of host-microbiome interactions often linked to bacterial metabolites derived from fiber fermentation (short-chain fatty acids) were not affected by AX supplementation when compared to non-accessible MCC.
+
+ CONCLUSION: This study demonstrates the efficacy of purified dietary fibers when used as supplements and suggests that satietogenic effects of AX may be linked to bacterial taxa that ferment the fiber or utilize breakdown products. Other effects are likely microbiome independent. The findings provide a basis for fiber-type specific therapeutic applications and their personalization.
+
+ TRIAL REGISTRATION: Clinicaltrials.gov, NCT02322112 , registered on July 3, 2015. Video Abstract. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers). 0 (Dietary Fiber). 0 (Leukocyte L1 Antigen Complex).
+Publication Type
+ Clinical Trial. Journal Article. Video-Audio Media. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs40168-022-01248-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Deehan&issn=2049-2618&title=Microbiome&atitle=Elucidating+the+role+of+the+gut+microbiota+in+the+physiological+effects+of+dietary+fiber.&volume=10&issue=1&spage=77&epage=&date=2022&doi=10.1186%2Fs40168-022-01248-5&pmid=35562794&sid=OVID:medline
+
+<503>
+Unique Identifier
+ 35546213
+Title
+ Leptin and its relationship with magnesium biomarkers in women with obesity.
+Source
+ BioMetals. 35(4):689-697, 2022 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Sousa Melo SR; Dos Santos LR; Morais JBS; Cruz KJC; de Oliveira ARS; da Silva NC; de Sousa GS; Payolla TB; Murata G; Bordin S; Henriques GS; do Nascimento Marreiro D
+Author NameID
+ de Sousa Melo, Stefany Rodrigues; ORCID: https://orcid.org/0000-0001-5308-3522
+ Dos Santos, Loanne Rocha; ORCID: https://orcid.org/0000-0002-5418-6715
+ Morais, Jennifer Beatriz Silva; ORCID: https://orcid.org/0000-0002-9055-7851
+ Cruz, Kyria Jayanne Climaco; ORCID: https://orcid.org/0000-0002-4489-702X
+ de Oliveira, Ana Raquel Soares; ORCID: https://orcid.org/0000-0001-5383-0137
+ da Silva, Nilmara Cunha; ORCID: https://orcid.org/0000-0002-4455-2080
+ de Sousa, Gustavo Santos; ORCID: https://orcid.org/0000-0003-0376-0585
+ Payolla, Tanyara Baliani; ORCID: https://orcid.org/0000-0003-0273-8589
+ Murata, Gilson; ORCID: https://orcid.org/0000-0003-3383-5410
+ Bordin, Silvana; ORCID: https://orcid.org/0000-0002-0192-8869
+ Henriques, Gilberto Simeone; ORCID: https://orcid.org/0000-0002-9110-5427
+ do Nascimento Marreiro, Dilina; ORCID: https://orcid.org/0000-0002-7550-1403
+Authors Full Name
+ de Sousa Melo, Stefany Rodrigues; Dos Santos, Loanne Rocha; Morais, Jennifer Beatriz Silva; Cruz, Kyria Jayanne Climaco; de Oliveira, Ana Raquel Soares; da Silva, Nilmara Cunha; de Sousa, Gustavo Santos; Payolla, Tanyara Baliani; Murata, Gilson; Bordin, Silvana; Henriques, Gilberto Simeone; do Nascimento Marreiro, Dilina.
+Institution
+ de Sousa Melo, Stefany Rodrigues. Graduate Program in Food and Nutrition, Federal University of Piaui, Teresina, PI, Brazil.
+ Dos Santos, Loanne Rocha. Graduate Program in Food and Nutrition, Federal University of Piaui, Teresina, PI, Brazil.
+ Morais, Jennifer Beatriz Silva. Graduate Program in Food and Nutrition, Federal University of Piaui, Teresina, PI, Brazil.
+ Cruz, Kyria Jayanne Climaco. Program in Food and Nutrition, Federal University of Piaui, Teresina, PI, Brazil.
+ de Oliveira, Ana Raquel Soares. Program in Food and Nutrition, Federal University of Piaui, Teresina, PI, Brazil.
+ da Silva, Nilmara Cunha. Graduate of Nutrition, Federal University of Piaui, Teresina, PI, Brazil.
+ de Sousa, Gustavo Santos. State University of Piaui, Universitary Hospital, Teresina, PI, Brazil.
+ Payolla, Tanyara Baliani. Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
+ Murata, Gilson. Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
+ Bordin, Silvana. Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
+ Henriques, Gilberto Simeone. Department of Nursing, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
+ do Nascimento Marreiro, Dilina. Department of Nutrition, Health Sciences Center, Federal University of Piaui, Rua Hugo Napoleao, 665, Ed. Palazzo Reale, Apto 2001, Jockey, Teresina, PI, CEP 64048-320, Brazil. dilina.marreiro@gmail.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Case-Control Studies
+ Female
+ Humans
+ *Leptin
+ *Magnesium
+ Middle Aged
+ Obesity
+ Young Adult
+Keyword Heading
+ Leptin
+ Magnesium
+ Metabolic Disorders
+ Nutrition
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Some studies have demonstrated the participation of leptin in magnesium metabolism. On the other hand, there is evidence of the role of magnesium in the leptin intracellular signaling pathway. Therefore, the aim of this study was to investigate the existence of a relationship between serum leptin concentrations and magnesium biomarkers in women with obesity. Case-control study involving 108 women aged between 20 and 50 years, divided into two groups: obese (n = 52) and control (n = 56). Body weight, height and waist circumference, body mass index, dietary magnesium intake, magnesium biomarkers and serum leptin concentrations were measured. Serum leptin concentrations showed a statistically significant difference between groups (p < 0.001). Mean values of magnesium intake were lower than intake recommended, and with no statistically significant difference between two groups (p > 0.05). Women with obesity had lower plasma and erythrocyte magnesium concentrations than control group did (p < 0.001). Magnesium concentrations found in the urine of women with obesity were higher than the control group was, with a statistically significant difference (p < 0.001). There was a correlation between serum leptin and magnesium biomarkers (p < 0.001). Women with obesity show an inadequate magnesium nutritional status characterized by low plasma and erythrocyte concentrations and high concentrations in urine, and they also have high serum leptin concentrations. Thus, it was possible to observe a correlation between hyperleptinemia and magnesium biomarkers, requiring further studies to determine whether the dysfunction of this hormone can influence the compartmentalization of the mineral in obese organisms. Copyright © 2022. The Author(s), under exclusive licence to Springer Nature B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). I38ZP9992A (Magnesium).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs10534-022-00393-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Sousa+Melo&issn=0966-0844&title=BioMetals&atitle=Leptin+and+its+relationship+with+magnesium+biomarkers+in+women+with+obesity.&volume=35&issue=4&spage=689&epage=697&date=2022&doi=10.1007%2Fs10534-022-00393-6&pmid=35546213&sid=OVID:medline
+
+<504>
+Unique Identifier
+ 35527326
+Title
+ Concordance between indirect fibrosis and steatosis indices and their predictors in subjects with overweight/obesity.
+Source
+ Eating & Weight Disorders: EWD. 27(7):2617-2627, 2022 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Melania G; Luisella V; Salvina DP; Francesca G; Amedea Silvia T; Fabrizia B; Maristella M; Filomena N; Kyriazoula C; Vassalle C
+Author NameID
+ Vassalle, Cristina; ORCID: http://orcid.org/0000-0003-3438-6450
+Authors Full Name
+ Melania, Gaggini; Luisella, Vigna; Salvina, Di Piazza; Francesca, Gori; Amedea Silvia, Tirelli; Fabrizia, Bamonti; Maristella, Maltinti; Filomena, Napolitano; Kyriazoula, Chatzianagnostou; Vassalle, Cristina.
+Institution
+ Melania, Gaggini. Institute of Clinical Physiology, CNR, Pisa, Italy.
+ Luisella, Vigna. Occupational Health Unit, Center of Obesity and Work EASO Collaborating Centers for Obesity Management, Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
+ Salvina, Di Piazza. Occupational Health Unit, Center of Obesity and Work EASO Collaborating Centers for Obesity Management, Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
+ Francesca, Gori. Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
+ Amedea Silvia, Tirelli. Laboratory of Clinical Chemistry and Microbiology Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
+ Fabrizia, Bamonti. Specialized in Clinical Chemistry and Biochemistry, Universita degli Studi di Milano, Milan, Italy.
+ Maristella, Maltinti. Fondazione CNR-Regione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica, CNR via Moruzzi 1, 56100, Pisa, Italy.
+ Filomena, Napolitano. Laboratory of Clinical Chemistry and Microbiology Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
+ Kyriazoula, Chatzianagnostou. Fondazione CNR-Regione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica, CNR via Moruzzi 1, 56100, Pisa, Italy.
+ Vassalle, Cristina. Fondazione CNR-Regione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica, CNR via Moruzzi 1, 56100, Pisa, Italy. cristina.vassalle@ftgm.it.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Humans
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/ep [Epidemiology]
+ Liver Cirrhosis/pa [Pathology]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+Keyword Heading
+ Concordance
+ Fibrosis
+ Non-invasive indices
+ Overweight and obesity
+ Steatosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The non-invasive assessment of steatosis/fibrosis tried to overcome some of peri-procedural risk of liver biopsy; for this, several indices of steatosis and fibrosis in liver have been proposed.
+
+ AIM: To evaluate concordance of non-invasive fibrosis and steatosis indices in a large population of adult subjects at risk of NAFLD, and how obesity and its physio-pathological features may interact with steatosis/fibrosis indexes and related biomarkers of cardio-metabolic risk.
+
+ METHODS: Indices of steatosis (fatty liver index-FLI), NAFLD liver fat score-NLFS)) and fibrosis (Fibrosis 4 (FIB-4), BARD, BAAT and FORN) were calculated in 1145 outpatients with overweight or obesity at risk for T2D and NAFLD. Indices were correlated with clinical variables.
+
+ RESULTS: Concordance between tests occurred in 81% of the overall values between FLI and NLFS, but was lower when comparing the other fibrosis scores (FIB-4 vs FORN 72%, FIB-4 vs BARD 36%, BARD vs FORN 46%, BARD vs BAAT 58%, FIB-4 vs BAAT 46%, BAAT vs FORN 62%). Each index was differently correlated with anthropometric, clinical and laboratory variables.
+
+ CONCLUSION: Indices evaluated retain low concordance, clinicians should be aware of these differences between steatosis/fibrosis scores when expressing a differential liver disease diagnosis or assessing the progression of a known liver disease.
+
+ LEVEL OF EVIDENCE: Level V, descriptive research. Copyright © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1007%2fs40519-022-01400-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Melania&issn=1124-4909&title=Eating+%26+Weight+Disorders%3A+EWD&atitle=Concordance+between+indirect+fibrosis+and+steatosis+indices+and+their+predictors+in+subjects+with+overweight%2Fobesity.&volume=27&issue=7&spage=2617&epage=2627&date=2022&doi=10.1007%2Fs40519-022-01400-y&pmid=35527326&sid=OVID:medline
+
+<505>
+Unique Identifier
+ 35506158
+Title
+ Effects of Physical Exercise on Cardiometabolic Biomarkers and Inflammatory Markers in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
+Source
+ Biological Research for Nursing. 24(4):519-529, 2022 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hejazi K; Ferrari F
+Author NameID
+ Hejazi, Keyvan; ORCID: https://orcid.org/0000-0002-4590-8018
+Authors Full Name
+ Hejazi, Keyvan; Ferrari, Filipe.
+Institution
+ Hejazi, Keyvan. Department of Physical Education and Sport Sciences, 185150Hakim Sabzevari University, Sabzevar, Iran.
+ Ferrari, Filipe. Graduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
+ Ferrari, Filipe. Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil.
+MeSH Subject Headings
+ *Adiponectin
+ Adolescent
+ Biomarkers
+ *Cardiovascular Diseases
+ Child
+ Exercise
+ Humans
+ Obesity
+ Randomized Controlled Trials as Topic
+Keyword Heading
+ adiponectin
+ children
+ insulin resistance index
+ meta-analysis
+ physical exercise
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The prevalence of obesity among children as well as the beneficial effects of physical exercise (PE) on weight loss has been determined by modulating the secretory factors of adipose tissue. PE has also been shown to have beneficial effects on obesity.
+
+ OBJECTIVE: The objective of this systematic review and meta-analysis was to investigate the effects of physical exercise (PE) on adiponectin and other important health markers in children.
+
+ DATA SOURCES: We searched 6 electronic databases (PubMed/Medline, Embase, Cochrane Library, Cinahl, Scopus, and Web of Science) and Google Scholar for randomized controlled trials from inception to December 15, 2021. We used random-effects models to estimate weighted mean difference (WMD) with 95% confidence intervals (CI).
+
+ STUDY SELECTION: Fourteen studies were included (N = 468 participants; mean age: 14 years).
+
+ RESULTS: In general, PE increased adiponectin (WMD: 0.91 microg/mL; 95% CI, 0.27 to 1.55, p = 0.005), high-density lipoprotein cholesterol (HDL-C) (WMD: 1.01 mg/dL; 95% CI, 0.33 to 1.69, p = 0.004), and VO2max (WMD: 2.52 mL.kg.min; 95% CI, 1.41 to 3.62, p = 0.00,001). The levels of c-reactive protein (WMD: -0.37 mg/L; 95% CI, -0.57 to -0.17, p = 0.0003), insulin (WMD: -4.61 muIU/ml; 95% CI, -5.46 to -3.76, p = 0.00,001), fasting glucose (WMD: -5.11 mg/dL; 95% CI, -7.88 to -2.34, p = 0.0003), and insulin resistance index (WMD: -1.44; 95% CI, -1.92 to -0.96, p = 0.00,001), decreased significantly.
+
+ CONCLUSION: Our study showed that PE may increase the level of adiponectin, HDL-C, and VO2max in children.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1177%2f10998004221099573
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hejazi&issn=1099-8004&title=Biological+Research+for+Nursing&atitle=Effects+of+Physical+Exercise+on+Cardiometabolic+Biomarkers+and+Inflammatory+Markers+in+Children%3A+A+Systematic+Review+and+Meta-Analysis+of+Randomized+Controlled+Trials.&volume=24&issue=4&spage=519&epage=529&date=2022&doi=10.1177%2F10998004221099573&pmid=35506158&sid=OVID:medline
+
+<506>
+Unique Identifier
+ 35501766
+Title
+ Multiple events case-control study in a prospective cohort to identify systemic, cellular, and molecular biomarkers of obesity-induced accelerated aging in 30-years-olds: the ObAGE study protocol.
+Source
+ BMC Geriatrics. 22(1):387, 2022 05 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Correa-Burrows P; Burrows R; Albala C; Court FA; Salech F; Sanhueza G; Gonzalez-Billault C
+Authors Full Name
+ Correa-Burrows, P; Burrows, R; Albala, C; Court, F A; Salech, F; Sanhueza, G; Gonzalez-Billault, C.
+Institution
+ Correa-Burrows, P. Institute of Nutrition & Food Technology, Universidad de Chile, Santiago, Chile. paulina.correa@inta.uchile.cl.
+ Burrows, R. Institute of Nutrition & Food Technology, Universidad de Chile, Santiago, Chile.
+ Albala, C. Institute of Nutrition & Food Technology, Universidad de Chile, Santiago, Chile.
+ Court, F A. Center for Integrative Biology, Universidad Mayor, Santiago, Chile.
+ Court, F A. Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
+ Court, F A. Buck Institute On Aging Research, Novato, CA, USA.
+ Salech, F. Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
+ Salech, F. Faculty of Medicine, Universidad de Chile, Santiago, Chile.
+ Sanhueza, G. Faculty of Social Sciences, Universidad de Chile, Santiago, Chile.
+ Gonzalez-Billault, C. Institute of Nutrition & Food Technology, Universidad de Chile, Santiago, Chile.
+ Gonzalez-Billault, C. Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
+ Gonzalez-Billault, C. Buck Institute On Aging Research, Novato, CA, USA.
+ Gonzalez-Billault, C. Faculty of Medicine, Universidad de Chile, Santiago, Chile.
+ Gonzalez-Billault, C. Faculty of Sciences, Universidad de Chile, Santiago, Chile.
+MeSH Subject Headings
+ Aging/ph [Physiology]
+ *Aging
+ Biomarkers
+ Case-Control Studies
+ Female
+ Humans
+ Male
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Prospective Studies
+Keyword Heading
+ Aging
+ Dysbiosis
+ Early-onset cardiometabolic risk
+ Epigentic age
+ Obesity
+ Resilience
+ Sarcopenia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Aging is characterized by a progressive loss of capacities linked to fundamental alterations/damage in multiple cellular and molecular pathways. It is the most significant risk factor for all non-communicable diseases (NCDs). Another contributing factor to the rise in NCDs is obesity. It has been suggested that obesity not only accelerates the onset of metabolic imbalances but also decreases lifespan and impacts cellular and molecular processes in a manner similar to aging. Obesity might accelerate the pace of aging. Guided by a lifecourse approach, we will explore how exposure to obesity in critical developmental stages disrupt homeostatic resilience mechanisms that preserve physiological integrity, inducing an early expression of aging phenotypes. Also, we will determine whether exposure to early psychosocial adversity influences vulnerability to obesity as a risk factor for accelerated aging.
+
+ METHODS: Multiple events case-control study embedded in a prospective cohort of Chileans at 30-31y, 50% females, of low- to-middle socioeconomic status, who participated in nutrition research since birth. At 23y, 25% had obesity and cardiometabolic risk was high. We will use a multi-layer approach including: anthropometric assessment; DXA scan for body composition; abdominal ultrasound of the liver; stool samples collection and sequencing of the ribosomal RNA 16S gene to characterize the gut microbiome; determination of age-related pro-inflammatory cytokynes and anti-inflammatory miokynes. For the first time in Chile, we will address age-related epigenetic changes using the Horvath's epigenetic clock. In a subset we will conduct a controlled physical challenge to characterize physical resilience (autophagy).
+
+ DISCUSSION: ObAGE is in an excellent position to: approach aging as a process whose expression involves multiple factors from the early stages of a person's life; understand how longitudinal changes in health trajectories impact the biological mechanisms of aging; identify potential resilience mechanisms that help prevent unhealthy aging. Because SLS participants are still young, our research setting combined with advanced scientific techniques may identify individuals or groups at risk of early onset health issues. Results from ObAGE may pave the way to address the contribution of obesity to aging through lifespan from cells to systems and might be instrumental to developing interventions to improve health span in the Chilean population.
+
+ TRIAL REGISTRATION: The proposed study does not consider any health care intervention on human participants. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12877-022-03032-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Correa-Burrows&issn=1471-2318&title=BMC+Geriatrics&atitle=Multiple+events+case-control+study+in+a+prospective+cohort+to+identify+systemic%2C+cellular%2C+and+molecular+biomarkers+of+obesity-induced+accelerated+aging+in+30-years-olds%3A+the+ObAGE+study+protocol.&volume=22&issue=1&spage=387&epage=&date=2022&doi=10.1186%2Fs12877-022-03032-4&pmid=35501766&sid=OVID:medline
+
+<507>
+Unique Identifier
+ 35477273
+Title
+ DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2-COX-2-TP Axis and NLRP3 Inflammasome Activation.
+Source
+ Hypertension. 79(7):1361-1373, 2022 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Valencia I; Vallejo S; Dongil P; Romero A; San Hipolito-Luengo A; Shamoon L; Posada M; Garcia-Olmo D; Carraro R; Erusalimsky JD; Romacho T; Peiro C; Sanchez-Ferrer CF
+Author NameID
+ Valencia, Ines; ORCID: https://orcid.org/0000-0002-6741-8554
+ Romero, Alejandra; ORCID: https://orcid.org/0000-0003-4759-3280
+ Shamoon, Licia; ORCID: https://orcid.org/0000-0002-9817-9525
+ Romacho, Tania; ORCID: https://orcid.org/0000-0002-0962-7163
+ Peiro, Concepcion; ORCID: https://orcid.org/0000-0002-9690-7816
+ Sanchez-Ferrer, Carlos F; ORCID: https://orcid.org/0000-0002-7340-3156
+Authors Full Name
+ Valencia, Ines; Vallejo, Susana; Dongil, Pilar; Romero, Alejandra; San Hipolito-Luengo, Alvaro; Shamoon, Licia; Posada, Maria; Garcia-Olmo, Damian; Carraro, Raffaelle; Erusalimsky, Jorge D; Romacho, Tania; Peiro, Concepcion; Sanchez-Ferrer, Carlos F.
+Institution
+ Valencia, Ines. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ Valencia, Ines. PhD Programme in Pharmacology and Physiology, Doctoral School (I.V., L.S.), Universidad Autonoma de Madrid, Spain.
+ Valencia, Ines. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+ Vallejo, Susana. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ Vallejo, Susana. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+ Dongil, Pilar. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ Dongil, Pilar. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+ Romero, Alejandra. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ Romero, Alejandra. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+ San Hipolito-Luengo, Alvaro. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ San Hipolito-Luengo, Alvaro. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+ Shamoon, Licia. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ Shamoon, Licia. PhD Programme in Pharmacology and Physiology, Doctoral School (I.V., L.S.), Universidad Autonoma de Madrid, Spain.
+ Shamoon, Licia. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+ Posada, Maria. Service of Surgery and Instituto de Investigacion Sanitaria del Hospital Fundacion Jimenez Diaz, Madrid, Spain (M.P., D.G.-O.).
+ Garcia-Olmo, Damian. Service of Surgery and Instituto de Investigacion Sanitaria del Hospital Fundacion Jimenez Diaz, Madrid, Spain (M.P., D.G.-O.).
+ Carraro, Raffaelle. Department of Medicine, School of Medicine (R.C.), Universidad Autonoma de Madrid, Spain.
+ Carraro, Raffaelle. Service of Endocrinology and Instituto de Investigacion Sanitaria del Hospital Universitario La Princesa, Madrid, Spain (R.C.).
+ Erusalimsky, Jorge D. School of Sport and Health Sciences, Cardiff Metropolitan University, United Kingdom (J.D.E.).
+ Romacho, Tania. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ Romacho, Tania. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+ Peiro, Concepcion. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ Peiro, Concepcion. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+ Sanchez-Ferrer, Carlos F. Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autonoma de Madrid, Spain.
+ Sanchez-Ferrer, Carlos F. Instituto de Investigacion Sanitaria del Hospital Universitario La Paz, Madrid, Spain (I.V., S.V., P.D., A.R., A.S.H.-L., L.S., T.R., C.P., C.F.S.-F.).
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Cellular Senescence
+ Cyclooxygenase 2/ge [Genetics]
+ Cyclooxygenase 2/me [Metabolism]
+ *Cyclooxygenase 2
+ Dipeptidyl Peptidase 4/me [Metabolism]
+ *Dipeptidyl Peptidase 4
+ Endothelial Cells/me [Metabolism]
+ Humans
+ Inflammasomes/me [Metabolism]
+ Inflammasomes/pd [Pharmacology]
+ *Inflammasomes
+ NLR Family, Pyrin Domain-Containing 3 Protein/ge [Genetics]
+ NLR Family, Pyrin Domain-Containing 3 Protein/me [Metabolism]
+ Obesity/me [Metabolism]
+ Receptor, PAR-2/ge [Genetics]
+ Receptor, PAR-2/me [Metabolism]
+ Receptors, Thromboxane/ge [Genetics]
+ Receptors, Thromboxane/me [Metabolism]
+Keyword Heading
+ cellular senescence
+ dipeptidyl peptidase 4
+ endothelium
+ inflammasomes
+ microvessels
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Abnormal accumulation of senescent cells in the vessel wall leads to a compromised vascular function contributing to vascular aging. Soluble DPP4 (dipeptidyl peptidase 4; sDPP4) secretion from visceral adipose tissue is enhanced in obesity, now considered a progeric condition. sDPP4 triggers vascular deleterious effects, albeit its contribution to vascular aging is unknown. We aimed to explore sDPP4 involvement in vascular aging, unraveling the molecular pathway by which sDPP4 acts on the endothelium.
+
+ METHODS: Human endothelial cell senescence was assessed by senescence-associated beta-galactosidase assay, visualization of DNA damage, and expression of prosenescent markers, whereas vascular function was evaluated by myography over human dissected microvessels. In visceral adipose tissue biopsies from a cohort of obese patients, we explored several age-related parameters in vitro and ex vivo.
+
+ RESULTS: By a common mechanism, sDPP4 triggers endothelial cell senescence and endothelial dysfunction in isolated human resistance arteries. sDPP4 activates the metabotropic receptor PAR2 (protease-activated receptor 2), COX-2 (cyclooxygenase 2) activity, and the production of TXA2 (thromboxane A2) acting over TP (thromboxane receptor) receptors (PAR2-COX-2-TP axis), leading to NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing 3) inflammasome activation. Obese patients exhibited impaired microarterial functionality in comparison to control nonobese counterparts. Importantly, endothelial dysfunction in obese patients positively correlated with greater expression of DPP4, prosenescent, and proinflammatory markers in visceral adipose tissue nearby the resistance arteries. Moreover, when DPP4 activity or sDPP4-induced prosenescent mechanism was blocked, endothelial dysfunction was restored back to levels of healthy subjects.
+
+ CONCLUSIONS: These results reveal sDPP4 as a relevant mediator in early vascular aging and highlight its capacity activating main proinflammatory mediators in the endothelium that might be pharmacologically tackled.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (F2RL1 protein, human). 0 (Inflammasomes). 0 (NLR Family, Pyrin Domain-Containing 3 Protein). 0 (NLRP3 protein, human). 0 (Receptor, PAR-2). 0 (Receptors, Thromboxane). EC 1-14-99-1 (Cyclooxygenase 2). EC 1-14-99-1 (PTGS2 protein, human). EC 3-4-14-5 (DPP4 protein, human). EC 3-4-14-5 (Dipeptidyl Peptidase 4).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1161%2fHYPERTENSIONAHA.121.18477
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Valencia&issn=0194-911X&title=Hypertension&atitle=DPP4+Promotes+Human+Endothelial+Cell+Senescence+and+Dysfunction+via+the+PAR2-COX-2-TP+Axis+and+NLRP3+Inflammasome+Activation.&volume=79&issue=7&spage=1361&epage=1373&date=2022&doi=10.1161%2FHYPERTENSIONAHA.121.18477&pmid=35477273&sid=OVID:medline
+
+<508>
+Unique Identifier
+ 35471642
+Title
+ Lipid peroxidation biomarkers associated with height and obesity measures in the opposite direction in women.
+Source
+ Obesity. 30(6):1257-1267, 2022 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li M; Zhao Y; Dai Q; Milne G; Long J; Cai Q; Chen Q; Zhang X; Lan Q; Rothman N; Gao YT; Shu XO; Zheng W; Yang G
+Author NameID
+ Yang, Gong; ORCID: https://orcid.org/0000-0002-7006-5825
+Authors Full Name
+ Li, Mengjie; Zhao, Yingya; Dai, Qi; Milne, Ginger; Long, Jirong; Cai, Qiuyin; Chen, Qingxia; Zhang, Xianglan; Lan, Qing; Rothman, Nathaniel; Gao, Yu-Tang; Shu, Xiao-Ou; Zheng, Wei; Yang, Gong.
+Institution
+ Li, Mengjie. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Zhao, Yingya. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Dai, Qi. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Milne, Ginger. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Long, Jirong. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Cai, Qiuyin. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Chen, Qingxia. Department of Biostatistics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Zhang, Xianglan. Tennessee Department of Health, Nashville, Tennessee, USA.
+ Lan, Qing. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
+ Rothman, Nathaniel. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
+ Gao, Yu-Tang. Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
+ Shu, Xiao-Ou. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Zheng, Wei. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
+ Yang, Gong. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/ur [Urine]
+ *F2-Isoprostanes
+ Female
+ Humans
+ Lipid Peroxidation
+ Obesity/ge [Genetics]
+ *Oxidative Stress
+Abstract
+ OBJECTIVE: This study aimed to investigate whether and how lipid peroxidation markers are associated with height and obesity measures.
+
+ METHODS: In two independent samples of women (Study 1: n = 1,005; Study 2: n = 1,158), systemic levels of lipid peroxidation were assessed by urinary markers F2 -isoprostanes (F2 -IsoPs) and its major metabolite (F2 -IsoP-M), with gas chromatography/negative ion chemical ionization mass spectrometry assays. Anthropometric parameters were directly measured and genetically estimated, and they were used in the primary analysis and in a Mendelian randomization analysis in relation to lipid peroxidation, respectively, with general linear models.
+
+ RESULTS: After adjusting for potential confounders, it was found that measured adult height was inversely associated with levels of F2 -IsoPs (beta = -0.89, p < 0.001) and F2 -IsoP-M (beta = -0.71, p = 0.003), whereas obesity measures were positively associated with F2 -IsoP-M (beta = 1.81, p < 0.001 for BMI; and beta = 0.77, p < 0.001 for waist circumference). Results were consistent between the two study samples. The opposite associations were further replicated when using genetically determined measures of height and obesity in the Mendelian randomization analysis. Moreover, analyses mutually adjusted for height and obesity measures suggested that these associations were independent of one another.
+
+ CONCLUSIONS: This study, for the first time, to our knowledge, reveals that a shared biological process (lipid peroxidation) is associated with both height and obesity measures but in the opposite direction. Copyright © 2022 The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (F2-Isoprostanes).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1002%2foby.23408
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1930-7381&title=Obesity&atitle=Lipid+peroxidation+biomarkers+associated+with+height+and+obesity+measures+in+the+opposite+direction+in+women.&volume=30&issue=6&spage=1257&epage=1267&date=2022&doi=10.1002%2Foby.23408&pmid=35471642&sid=OVID:medline
+
+<509>
+Unique Identifier
+ 35458178
+Title
+ Influence of Obesity on Bone Turnover Markers and Fracture Risk in Postmenopausal Women.
+Source
+ Nutrients. 14(8), 2022 Apr 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lopez-Gomez JJ; Perez-Castrillon JL; Garcia de Santos I; Perez-Alonso M; Izaola-Jauregui O; Primo-Martin D; De Luis-Roman DA
+Author NameID
+ Lopez-Gomez, Juan J; ORCID: https://orcid.org/0000-0003-3144-343X
+ Perez-Castrillon, Jose L; ORCID: https://orcid.org/0000-0002-1723-217X
+ De Luis-Roman, Daniel A; ORCID: https://orcid.org/0000-0002-1745-9315
+Authors Full Name
+ Lopez-Gomez, Juan J; Perez-Castrillon, Jose L; Garcia de Santos, Isabel; Perez-Alonso, Maria; Izaola-Jauregui, Olatz; Primo-Martin, David; De Luis-Roman, Daniel A.
+Institution
+ Lopez-Gomez, Juan J. Department of Endocrinology and Nutricion, Hospital Clinico Universitario de Valladolid, 47003 Valladolid, Spain.
+ Lopez-Gomez, Juan J. Centro de Investigacion Endocrinologia y Nutricion (IENVA), University of Valladolid, 47002 Valladolid, Spain.
+ Perez-Castrillon, Jose L. Centro de Investigacion Endocrinologia y Nutricion (IENVA), University of Valladolid, 47002 Valladolid, Spain.
+ Perez-Castrillon, Jose L. Department of Internal Medicine, Hospital Universitario Rio Hortega, 47012 Valladolid, Spain.
+ Garcia de Santos, Isabel. School of Medicine, University of Valladolid, 47002 Valladolid, Spain.
+ Perez-Alonso, Maria. Centro de Investigacion Endocrinologia y Nutricion (IENVA), University of Valladolid, 47002 Valladolid, Spain.
+ Izaola-Jauregui, Olatz. Department of Endocrinology and Nutricion, Hospital Clinico Universitario de Valladolid, 47003 Valladolid, Spain.
+ Izaola-Jauregui, Olatz. Centro de Investigacion Endocrinologia y Nutricion (IENVA), University of Valladolid, 47002 Valladolid, Spain.
+ Primo-Martin, David. Department of Endocrinology and Nutricion, Hospital Clinico Universitario de Valladolid, 47003 Valladolid, Spain.
+ Primo-Martin, David. Centro de Investigacion Endocrinologia y Nutricion (IENVA), University of Valladolid, 47002 Valladolid, Spain.
+ De Luis-Roman, Daniel A. Department of Endocrinology and Nutricion, Hospital Clinico Universitario de Valladolid, 47003 Valladolid, Spain.
+ De Luis-Roman, Daniel A. Centro de Investigacion Endocrinologia y Nutricion (IENVA), University of Valladolid, 47002 Valladolid, Spain.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Bone Density
+ Bone Remodeling/ph [Physiology]
+ *Bone Remodeling
+ *Bone Resorption
+ Collagen Type I
+ Female
+ Fractures, Bone/ep [Epidemiology]
+ Fractures, Bone/et [Etiology]
+ *Fractures, Bone
+ Humans
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity
+ Osteoporosis, Postmenopausal
+ Parathyroid Hormone
+ Peptides
+ *Postmenopause
+ Prospective Studies
+ Vitamin D
+ Vitamins
+Keyword Heading
+ bone metabolism
+ bone turnover markers
+ fracture
+ obesity
+ osteoporosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background and aims: The relationship between obesity and bone metabolism is controversial. In recent decades, the protective role of obesity in the development of osteoporosis is questioned. The aims of this study are the following: to evaluate the differences in bone turnover markers between postmenopausal women with and without obesity and to compare the risk of fracture at five years between these groups. Methods: An observational longitudinal prospective cohort study of postmenopausal women with obesity (O) (body mass index (BMI) > 30 kg/m2) and non-obesity (NoO) (BMI < 30 kg/m2) is designed. 250 postmenopausal women are included in the study (NoO: 124 (49.6%) and O: 126 (50.4%)). It measures epidemiological variables, dietary variables (calcium intake, vitamin D intake, smoking, alcohol consumption, and physical activity), biochemicals (beta-crosslap, type I procollagen amino-terminal peptide (P1NP), 25OH-vitamin D, and parathyroid hormone (PTH)), anthropometric variables, and fracture data five years after the start of the study. The mean age is 56.17 (3.91) years. Women with obesity showed lower levels of vitamin D (O: 17.27 (7.85) ng/mL, NoO: 24.51 (9.60) ng/mL; p < 0.01), and higher levels of PTH (O: 53.24 (38.44-65.96) pg/mL, NoO: 35.24 (25.36-42.40) pg/mL; p < 0.01). Regarding the bone formation marker (P1NP), it was found to be high in women without obesity, O: 45.46 (34.39-55.16) ng/mL, NoO: 56.74 (45.34-70.74) ng/mL; p < 0.01; the bone resorption marker (beta-crosslap) was found to be high in women with obesity, being significant in those older than 59 years (O: 0.39 (0.14) ng/mL, NoO 0.24 (0.09) ng/mL; p < 0.05). No differences are observed in the risk of fracture at 5 years based on BMI (OR = 0.90 (95%CI 0.30-2.72); p = 0.85). Conclusions : Postmenopausal women with obesity showed lower levels of bone formation markers; older women with obesity showed higher markers of bone resorption.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Collagen Type I). 0 (Parathyroid Hormone). 0 (Peptides). 0 (Vitamins). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14081617
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lopez-Gomez&issn=2072-6643&title=Nutrients&atitle=Influence+of+Obesity+on+Bone+Turnover+Markers+and+Fracture+Risk+in+Postmenopausal+Women.&volume=14&issue=8&spage=&epage=&date=2022&doi=10.3390%2Fnu14081617&pmid=35458178&sid=OVID:medline
+
+<510>
+Unique Identifier
+ 35458107
+Title
+ Effects of Diet-Induced Weight Loss on Plasma Markers for Cholesterol Absorption and Synthesis: Secondary Analysis of a Randomized Trial in Abdominally Obese Men.
+Source
+ Nutrients. 14(8), 2022 Apr 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mashnafi S; Plat J; Mensink RP; Joris PJ; Kusters YHAM; Houben AJHM; Stehouwer CDA; Schalkwijk CG; Baumgartner S
+Author NameID
+ Mashnafi, Sultan; ORCID: https://orcid.org/0000-0002-8141-631X
+ Plat, Jogchum; ORCID: https://orcid.org/0000-0002-1570-9608
+ Joris, Peter J; ORCID: https://orcid.org/0000-0001-6852-5776
+ Houben, Alfons J H M; ORCID: https://orcid.org/0000-0002-1747-8452
+Authors Full Name
+ Mashnafi, Sultan; Plat, Jogchum; Mensink, Ronald P; Joris, Peter J; Kusters, Yvo H A M; Houben, Alfons J H M; Stehouwer, Coen D A; Schalkwijk, Casper G; Baumgartner, Sabine.
+Institution
+ Mashnafi, Sultan. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+ Mashnafi, Sultan. Department of Medical Basic Sciences, Faculty of Applied Medical Sciences, AlBaha University, AlBaha 65779-7738, Saudi Arabia.
+ Plat, Jogchum. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+ Mensink, Ronald P. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+ Joris, Peter J. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+ Kusters, Yvo H A M. Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+ Houben, Alfons J H M. Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+ Stehouwer, Coen D A. Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+ Schalkwijk, Casper G. Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+ Baumgartner, Sabine. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.
+MeSH Subject Headings
+ Biomarkers
+ Cholestanol
+ Cholesterol
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2
+ Diet, Reducing
+ Humans
+ Male
+ Obesity
+ Phytosterols/me [Metabolism]
+ *Phytosterols
+ Weight Loss
+Keyword Heading
+ cholesterol absorption
+ cholesterol precursors
+ cholesterol synthesis
+ diet-induced weight loss
+ intrahepatic lipid
+ non-cholesterol sterols
+ plant sterols
+ subcutaneous fat
+ visceral fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cross-sectional studies have shown that obesity is associated with lower intestinal cholesterol absorption and higher endogenous cholesterol synthesis. These metabolic characteristics have also been observed in patients with type 2 diabetes, metabolic syndrome, steatosis or cholestasis. The number of intervention studies evaluating the effect of weight loss on these metabolic characteristics is, however, limited, while the role of the different fat compartments has not been studied into detail. In a randomized trial, abdominally obese men (N = 54) followed a 6-week very low caloric (VLCD) diet, followed by a 2 week weight-maintenance period. Non-cholesterol sterols were measured at baseline and after 8 weeks, and compared to levels in lean participants (N = 25). After weight loss, total cholesterol (TC)-standardized cholestanol levels increased by 0.18 micromol/mmol (p < 0.001), while those of campesterol and lathosterol decreased by 0.25 micromol/mmol (p < 0.05) and 0.39 micromol/mmol (p < 0.001), respectively. Moreover, after weight loss, TC-standardized lathosterol and cholestanol levels were comparable to those of lean men. Increases in TC-standardized cholestanol after weight loss were significantly associated with changes in waist circumference (p < 0.01), weight (p < 0.001), BMI (p < 0.001) and visceral fat (p < 0.01), but not with subcutaneous and intrahepatic lipids. In addition, cross-sectional analysis showed that visceral fat fully mediated the association between BMI and TC-standardized cholestanol levels. Intrahepatic lipid content was a partial mediator for the association between BMI and TC-standardized lathosterol levels. In conclusion, diet-induced weight loss decreased cholesterol synthesis and increased cholesterol absorption. The increase in TC-standardized cholestanol levels was not only related to weight loss, but also to a decrease in visceral fat volume. Whether these metabolic changes ameliorate other metabolic risk factors needs further study.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phytosterols). 8M308U816E (Cholestanol). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14081546
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mashnafi&issn=2072-6643&title=Nutrients&atitle=Effects+of+Diet-Induced+Weight+Loss+on+Plasma+Markers+for+Cholesterol+Absorption+and+Synthesis%3A+Secondary+Analysis+of+a+Randomized+Trial+in+Abdominally+Obese+Men.&volume=14&issue=8&spage=&epage=&date=2022&doi=10.3390%2Fnu14081546&pmid=35458107&sid=OVID:medline
+
+<511>
+Unique Identifier
+ 35457744
+Title
+ Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Obese Women.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 19(8), 2022 04 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lockard B; Mardock M; Oliver JM; Byrd M; Simbo S; Jagim AR; Kresta J; Baetge CC; Jung YP; Koozehchian MS; Khanna D; Rasmussen C; Kreider RB
+Author NameID
+ Lockard, Brittanie; ORCID: https://orcid.org/0000-0003-1290-7753
+ Jagim, Andrew R; ORCID: https://orcid.org/0000-0002-6651-5096
+ Koozehchian, Majid S; ORCID: https://orcid.org/0000-0003-1257-9876
+ Kreider, Richard B; ORCID: https://orcid.org/0000-0002-3906-1658
+Authors Full Name
+ Lockard, Brittanie; Mardock, Michelle; Oliver, Jonathan M; Byrd, Mike; Simbo, Sunday; Jagim, Andrew R; Kresta, Julie; Baetge, Claire C; Jung, Yanghoon Peter; Koozehchian, Majid S; Khanna, Deepesh; Rasmussen, Chris; Kreider, Richard B.
+Institution
+ Lockard, Brittanie. School of Nursing and Health Professions, University of the Incarnate Word, San Antonio, TX 78209, USA.
+ Mardock, Michelle. Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health and Kinesiology, Texas A & M University, College Station, TX 77843, USA.
+ Oliver, Jonathan M. Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health and Kinesiology, Texas A & M University, College Station, TX 77843, USA.
+ Byrd, Mike. Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health and Kinesiology, Texas A & M University, College Station, TX 77843, USA.
+ Byrd, Mike. Byrd's Eye Enterprises, Inc., Forney, TX 75126, USA.
+ Simbo, Sunday. Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health and Kinesiology, Texas A & M University, College Station, TX 77843, USA.
+ Simbo, Sunday. Center for Translational Research in Aging & Longevity, Human Clinical Research Facility, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.
+ Jagim, Andrew R. Department of Sports Medicine, Mayo Clinic Health System, Onalaska, WI 54650, USA.
+ Kresta, Julie. College of Education and Human Development, Texas A&M University Central-Texas, Killeen, TX 76549, USA.
+ Baetge, Claire C. Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health and Kinesiology, Texas A & M University, College Station, TX 77843, USA.
+ Jung, Yanghoon Peter. CJ CheilJedang, Suwon 16495, Korea.
+ Koozehchian, Majid S. Department of Kinesiology, Jacksonville State University, Jacksonville, AL 36265, USA.
+ Khanna, Deepesh. Department of Foundational Sciences, Nova Southeastern University, Clearwater, FL 33759, USA.
+ Rasmussen, Chris. Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health and Kinesiology, Texas A & M University, College Station, TX 77843, USA.
+ Kreider, Richard B. Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health and Kinesiology, Texas A & M University, College Station, TX 77843, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Composition
+ Body Mass Index
+ Diet
+ Exercise
+ Female
+ Humans
+ Obesity/th [Therapy]
+ *Obesity
+ Outcome Assessment, Health Care
+ Retrospective Studies
+ *Weight Loss
+Keyword Heading
+ body composition
+ fat loss
+ high-protein diet
+ training adaptations
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To compare the efficacy of two popular weight loss approaches on weight loss, body composition, and markers of health in sedentary obese women.
+
+ METHODS: In total, 51 sedentary women (age 34.5 +/- 7.7 yrs.; weight 90.0 +/- 14.5 kg; BMI 34.0 +/- 5.1 kg/m2; 46.5 +/- 7.0% fat) were matched and randomized to participate in the Weight Watchers R Momentum TM (WW) or Curves R (CV) Fitness and Weight Management program for 16 weeks. Participants in the WW group (n = 27) were provided a point-based diet program, received weekly progress checks and counseling, and were encouraged to exercise. Participants in the CV group (n = 24) followed a menu-based higher protein/low-fat diet (1200 kcal/d) for 1 week; 1500 kcal/d diet for 3 weeks; and 2000-2500 kcals/d for 2 weeks that was repeated three times (except the last segment) while participating in a supervised circuit-style resistance training program (3 d/wk). A general linear model (GLM) with repeated measures was used to analyze data and are presented as mean changes from baseline (mean [UL, LL]).
+
+ RESULTS: Supervised CV training resulted in greater amounts of vigorous and total physical activity. After 16 weeks, both groups lost weight (WW -6.1 [-7.8, -4.6], CV -4.9 [-6.2, -3.2] kg, p = 0.264). Participants in the CV group observed greater reductions in fat mass (WW -2.9 [-6.7, -0.2], CV -6.4 [-9.2, -3.6] kg, p = 0.081) and increases in lean mass (WW -2.5 [-4.3, -0.7], CV 1.3 [-0.6, 3.2] kg, p = 0.005) resulting in more favorable changes in percent body fat (WW -1.4 [-4.1, 1.2], CV -4.7 [-7.5, -1.8]%, p = 0.098). Both groups observed improvements in peak aerobic capacity and muscular endurance, although bench press lifting volume was greater in the CV group. Those in the CV group experienced a greater increase in HDLc and reduction in the CHL-HDLc ratio and triglycerides.
+
+ CONCLUSION: Both interventions promoted weight loss and improvements in fitness and markers of health. The CV program, which included supervised resistance training and higher protein diet menus, promoted greater fat loss, increases in lean mass, and improvements in percent body fat and blood lipids.
+
+ TRIAL REGISTRATION: clinicaltrials.gov, #NCT04372771, registered retrospectively 1 May 2020.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijerph19084877
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lockard&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Comparison+of+Two+Diet+and+Exercise+Approaches+on+Weight+Loss+and+Health+Outcomes+in+Obese+Women.&volume=19&issue=8&spage=&epage=&date=2022&doi=10.3390%2Fijerph19084877&pmid=35457744&sid=OVID:medline
+
+<512>
+Unique Identifier
+ 35443473
+Title
+ Evaluation of Interleukin 6(Il-6), Tumor Necrosis Factor Alpha (Tnf-alpha) and Paraoxonase 1(Pon 1) in Obese and Non-Obese Metabolic Syndrome.
+Source
+ Journal of the Association of Physicians of India. 70(4):11-12, 2022 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Samy K; Porwal YC; Yadav A
+Authors Full Name
+ Samy, Karuppu; Porwal, Y C; Yadav, Amita.
+Institution
+ Samy, Karuppu. Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi.
+ Porwal, Y C. Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi.
+ Yadav, Amita. Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi.
+MeSH Subject Headings
+ *Aryldialkylphosphatase/bl [Blood]
+ Biomarkers
+ Body Mass Index
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2
+ Female
+ Humans
+ *Interleukin-6/bl [Blood]
+ Male
+ *Metabolic Syndrome
+ Obesity/co [Complications]
+ Obesity, Abdominal/co [Complications]
+ Tumor Necrosis Factor-alpha
+Abstract
+ Metabolic syndrome is a multiplex of the risk factor for the development of type 2 diabetes and cardiovascular disease and it reflects the clustering of multiple risk factors resulting from obesity and insulin resistance. Despite its predominance in obese individuals, MS does occur in non-obese individuals. Many individuals characterized as normal weight as per their body mass index (BMI), have increased visceral adiposity thereby leading to an unfavorable inflammatory cytokine profile and altered PON levels. There are limited studies from India concerning inflammatory cytokines in obesity and MS in general and non-obese patients with MS in particular.
+
+ MATERIAL: Study Design: An observational cross sectional comparative study was conducted which included 65 patients in each Obese and Non-obese Metabolic Syndrome group. The difference in biomarker profile between the two groups was studied.
+
+ MATERIAL AND METHODS: Patients were subjected to detailed history, physical and anthropometric examination. NCEP-ATP III criteria were used for the diagnosis of Metabolic Syndrome. Patients were considered obese if BMI >= 25kg/m2. Normal weight individuals with MS were further subdivided into two groups based on the presence of abdominal obesity (WC cut off 90 cm for men and 80 cm for women). Blood samples were collected for analysis for FBS, Lipid Profile, and HbA1c. Blood samples for biomarker analysis were collected in clotted sample tubes followed by deep freezing and analyzed using ELISA kits. The results were interpreted according to manufacturer guidelines.
+
+ OBSERVATION: There were no significant differences in IL-6, TNF-alpha, and PON 1 profiles among Obese and Non-obese Metabolic Syndrome. Moreover significant (p < 0.05) positive correlation was seen in TNF-alpha levels among patients with abdominal obesity than without abdominal obesity among the Non-obese group.
+
+ CONCLUSION: TNF-alpha levels were significantly higher among patients with abdominal obesity than without abdominal obesity among the Non-obese group. There was no significant difference in IL-6, TNF-alpha, and PON 1 among Obese and Non-obese MS. This finding indicates that apart from adipose tissue, other factors are also responsible for the development of MS and its associated proinflammatory profile. There could be a significant contribution of genetic and epigenetic factors which need to be further explored. Copyright © Journal of the Association of Physicians of India 2011.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IL6 protein, human). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha). EC 3-1-8-1 (Aryldialkylphosphatase). EC 3-1-8-1 (PON1 protein, human).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&AN=35443473
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Samy&issn=0004-5772&title=Journal+of+the+Association+of+Physicians+of+India&atitle=Evaluation+of+Interleukin+6%28Il-6%29%2C+Tumor+Necrosis+Factor+Alpha+%28Tnf-alpha%29+and+Paraoxonase+1%28Pon+1%29+in+Obese+and+Non-Obese+Metabolic+Syndrome.&volume=70&issue=4&spage=11&epage=12&date=2022&doi=&pmid=35443473&sid=OVID:medline
+
+<513>
+Unique Identifier
+ 35436409
+Title
+ Contribution of markers of adiposopathy and adipose cell size in predicting insulin resistance in women of varying age and adiposity.
+Source
+ Adipocyte. 11(1):175-189, 2022 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tremblay EJ; Tchernof A; Pelletier M; Chabot N; Joanisse DR; Mauriege P
+Authors Full Name
+ Tremblay, Eve-Julie; Tchernof, Andre; Pelletier, Melissa; Chabot, Nicolas; Joanisse, Denis R; Mauriege, Pascale.
+Institution
+ Tremblay, Eve-Julie. Departement de kinesiologie, Faculte de medecine, Universite Laval, Quebec, Canada.
+ Tremblay, Eve-Julie. Centre de recherche de l'institut Universitaire de cardiologie et pneumologie de Quebec (CRIUCPQ), Universite Laval, Quebec, Canada.
+ Tchernof, Andre. Centre de recherche de l'institut Universitaire de cardiologie et pneumologie de Quebec (CRIUCPQ), Universite Laval, Quebec, Canada.
+ Tchernof, Andre. Ecole de Nutrition, Faculte des sciences de l'agriculture et de l'alimentation, Universite Laval, Quebec, Canada.
+ Pelletier, Melissa. Centre de recherche de l'institut Universitaire de cardiologie et pneumologie de Quebec (CRIUCPQ), Universite Laval, Quebec, Canada.
+ Chabot, Nicolas. Departement de kinesiologie, Faculte de medecine, Universite Laval, Quebec, Canada.
+ Chabot, Nicolas. Centre de recherche de l'institut Universitaire de cardiologie et pneumologie de Quebec (CRIUCPQ), Universite Laval, Quebec, Canada.
+ Joanisse, Denis R. Departement de kinesiologie, Faculte de medecine, Universite Laval, Quebec, Canada.
+ Joanisse, Denis R. Centre de recherche de l'institut Universitaire de cardiologie et pneumologie de Quebec (CRIUCPQ), Universite Laval, Quebec, Canada.
+ Mauriege, Pascale. Departement de kinesiologie, Faculte de medecine, Universite Laval, Quebec, Canada.
+ Mauriege, Pascale. Centre de recherche de l'institut Universitaire de cardiologie et pneumologie de Quebec (CRIUCPQ), Universite Laval, Quebec, Canada.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Adiposity
+ Adult
+ Biomarkers/me [Metabolism]
+ Cell Size
+ Female
+ Humans
+ *Insulin Resistance
+ Lipids
+ Lipoproteins/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+Abstract
+ Adipose tissue (AT) dysfunctions, such as adipocyte hypertrophy, macrophage infiltration and secretory adiposopathy (low plasma adiponectin/leptin, A/L, ratio), associate with metabolic disorders. However, no study has compared the relative contribution of these markers to cardiometabolic risk in women of varying age and adiposity. Body composition, regional AT distribution, lipid-lipoprotein profile, glucose homeostasis and plasma A and L levels were determined in 67 women (age: 40-62 years; BMI: 17-41 kg/m2). Expression of macrophage infiltration marker CD68 and adipocyte size were measured from subcutaneous abdominal (SCABD) and omental (OME) fat. AT dysfunction markers correlated with most lipid-lipoprotein levels. The A/L ratio was negatively associated with fasting insulinemia and HOMA-IR, while SCABD or OME adipocyte size and SCABD CD68 expression were positively related to these variables. Combination of tertiles of largest adipocyte size and lowest A/L ratio showed the highest HOMA-IR. Multiple regression analyses including these markers and TAG levels revealed that the A/L ratio was the only predictor of fasting insulinemia and HOMA-IR. The contribution of the A/L ratio was superseded by adipose cell size in the model where the latter replaced TAGs. Finally, leptinemia was a better predictor of IR than adipocyte size and the A/L ratio in our participants sample.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 0 (Lipoproteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1080%2f21623945.2022.2059902
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tremblay&issn=2162-3945&title=Adipocyte&atitle=Contribution+of+markers+of+adiposopathy+and+adipose+cell+size+in+predicting+insulin+resistance+in+women+of+varying+age+and+adiposity.&volume=11&issue=1&spage=175&epage=189&date=2022&doi=10.1080%2F21623945.2022.2059902&pmid=35436409&sid=OVID:medline
+
+<514>
+Unique Identifier
+ 35432185
+Title
+ Predictive Effect of Triglyceride Glucose-Related Parameters, Obesity Indices, and Lipid Ratios for Diabetes in a Chinese Population: A Prospective Cohort Study.
+Source
+ Frontiers in Endocrinology. 13:862919, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li X; Sun M; Yang Y; Yao N; Yan S; Wang L; Hu W; Guo R; Wang Y; Li B
+Authors Full Name
+ Li, Xiaotong; Sun, Mengzi; Yang, Yixue; Yao, Nan; Yan, Shoumeng; Wang, Ling; Hu, Wenyu; Guo, Ruirui; Wang, Yuxiang; Li, Bo.
+Institution
+ Li, Xiaotong. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Sun, Mengzi. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Yang, Yixue. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Yao, Nan. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Yan, Shoumeng. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Wang, Ling. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Hu, Wenyu. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Guo, Ruirui. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Wang, Yuxiang. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+ Li, Bo. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
+MeSH Subject Headings
+ Biomarkers
+ Blood Glucose
+ China/ep [Epidemiology]
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus
+ Glucose
+ Humans
+ Longitudinal Studies
+ Obesity/ep [Epidemiology]
+ *Prediabetic State
+ Prospective Studies
+ Risk Factors
+ Triglycerides
+Keyword Heading
+ CHARLS
+ diabetes mellitus
+ lipid ratios
+ obesity
+ triglyceride glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: The purpose of this study was to evaluate the association between triglyceride glucose (TyG) index and new-onset diabetes under different glycemic states and to compare the predictive value of TyG-related parameters, obesity indices, and lipid ratios for new-onset diabetes.
+
+ Methods: Data were collected from the China Health and Retirement Longitudinal Study (CHARLS), consisting of 6,258 participants aged >=45 years. Participants were grouped according to their glycemic states. Cox proportional hazards models and restricted cubic spline regression were used to explore the association between TyG index and diabetes. Cox proportional hazard models were applied to confirm the predictive value of the optimal marker. Receiver operating characteristic (ROC) curves were used to compare the predictive value.
+
+ Results: TyG index was positively correlated with the risk of diabetes (hazard ratio (HR), 1.75; 95% confidence interval (CI), 1.56-1.97), and the linear association existed (p < 0.001). The highest correlation with diabetes was visceral adiposity index (VAI) (HR, 2.04; 95% CI, 1.44-2.90) in normal fasting glucose (NFG) group and TyG-body mass index (TyG-BMI) (HR, 2.53; 95% CI, 1.97-3.26) in impaired fasting glucose (IFG) group. The largest area under curve (AUC) was observed in TyG-waist-to-height ratio (TyG-WHtR) in the NFG group (AUC, 0.613; 95% CI, 0.527-0.700), and TyG-BMI had the highest AUC in the IFG group (AUC, 0.643; 95% CI, 0.601-0.685).
+
+ Conclusion: The association between TyG index and new-onset diabetes was positive and linear. TyG-WHtR was a clinically effective marker for identifying the risks of diabetes in the NFG group and TyG-BMI was an effective marker to predict diabetes in the IFG group. Copyright © 2022 Li, Sun, Yang, Yao, Yan, Wang, Hu, Guo, Wang and Li.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.862919
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Predictive+Effect+of+Triglyceride+Glucose-Related+Parameters%2C+Obesity+Indices%2C+and+Lipid+Ratios+for+Diabetes+in+a+Chinese+Population%3A+A+Prospective+Cohort+Study.&volume=13&issue=&spage=862919&epage=&date=2022&doi=10.3389%2Ffendo.2022.862919&pmid=35432185&sid=OVID:medline
+
+<515>
+Unique Identifier
+ 35428237
+Title
+ Socioeconomic inequalities in physiological risk biomarkers and the role of lifestyles among Russians aged 35-69 years.
+Source
+ International Journal for Equity in Health. 21(1):51, 2022 04 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Trias-Llimos S; Cook S; Eggen AE; Kudryavtsev AV; Malyutina S; Shkolnikov VM; Leon DA
+Author NameID
+ Trias-Llimos, Sergi; ORCID: https://orcid.org/0000-0002-8052-6736
+Authors Full Name
+ Trias-Llimos, Sergi; Cook, Sarah; Eggen, Anne Elise; Kudryavtsev, Alexander V; Malyutina, Sofia; Shkolnikov, Vladimir M; Leon, David A.
+Institution
+ Trias-Llimos, Sergi. Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK. strias@ced.uab.cat.
+ Trias-Llimos, Sergi. Centre d'Estudis Demografics, Centres de Recerca de Catalunya (CERCA), Carrer de Ca n'Altayo, Edifici E2, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain. strias@ced.uab.cat.
+ Cook, Sarah. Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
+ Cook, Sarah. National Heart and Lung Institute, Imperial College London, London, UK.
+ Eggen, Anne Elise. Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromso, Norway.
+ Kudryavtsev, Alexander V. Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromso, Norway.
+ Kudryavtsev, Alexander V. Central Scientific Research Laboratory, Northern State Medical University, Arkhangelsk, Russia.
+ Malyutina, Sofia. Research Institute of Internal and Preventive Medicine - Branch of IC&G SB RAS, Novosibirsk, Russia.
+ Malyutina, Sofia. Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
+ Shkolnikov, Vladimir M. Laboratory for Demographic Data, Max Planck Institute for Demographic Research, Rostock, Germany.
+ Shkolnikov, Vladimir M. International Laboratory for Population and Health, National Research University Higher School of Economics, Moscow, Russia.
+ Leon, David A. Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
+ Leon, David A. Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromso, Norway.
+MeSH Subject Headings
+ Biomarkers
+ C-Reactive Protein/an [Analysis]
+ *C-Reactive Protein
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Cholesterol
+ Cross-Sectional Studies
+ Educational Status
+ Female
+ Glycated Hemoglobin
+ Humans
+ Life Style
+ Male
+ Obesity
+ Risk Factors
+ Socioeconomic Factors
+ Triglycerides
+Keyword Heading
+ Cardiovascular risk
+ Eastern Europe
+ Health behaviours
+ Health inequities
+ Russia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Socioeconomic inequalities in cardiovascular (CVD) health outcomes are well documented. While Russia has one of the highest levels of CVD mortality in the world, the literature on contemporary socio-economic inequalities in biomarker CVD risk factors is sparse. This paper aims to assess the extent and the direction of SEP inequalities in established physiological CVD risk biomarkers, and to explore the role of lifestyle factors in explaining SEP inequalities in physiological CVD risk biomarkers.
+
+ METHODS: We used cross-sectional data from a general population-based survey of Russians aged 35-69 years living in two cities (n = 4540, Know Your Heart study 2015-18). Logistic models were used to assess the associations between raised physiological risk biomarkers levels (blood pressure levels, cholesterol levels, triglycerides, HbA1C, and C-reactive protein) and socioeconomic position (SEP) (education and household financial constraints) adjusting for age, obesity, smoking, alcohol and health-care seeking behavior.
+
+ RESULTS: High education was negatively associated with a raised risk of blood pressure (systolic and diastolic) and C-reactive protein for both men and women. High education was positively associated with total cholesterol, with higher HDL levels among women, and with low triglycerides and HbA1c levels among men. For the remaining risk biomarkers, we found little statistical support for SEP inequalities. Adjustment for lifestyle factors, and particularly BMI and waist-hip ratio, led to a reduction in the observed SEP inequalities in raised biomarkers risk levels, especially among women. High financial constraints were weakly associated with high risk biomarkers levels, except for strong evidence for an association with C-reactive protein (men).
+
+ CONCLUSIONS: Notable differences in risk biomarkers inequalities were observed according to the SEP measure employed. Clear educational inequalities in raised physiological risk biomarkers levels, particularly in blood pressure and C-reactive protein were seen in Russia and are partly explained by lifestyle factors, particularly obesity among women. These findings provide evidence-based information on the need for tackling health inequalities in the Russian population, which may help to further contribute to CVD mortality decline. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Triglycerides). 9007-41-4 (C-Reactive Protein). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12939-022-01650-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Trias-Llimos&issn=1475-9276&title=International+Journal+for+Equity+in+Health&atitle=Socioeconomic+inequalities+in+physiological+risk+biomarkers+and+the+role+of+lifestyles+among+Russians+aged+35-69+years.&volume=21&issue=1&spage=51&epage=&date=2022&doi=10.1186%2Fs12939-022-01650-3&pmid=35428237&sid=OVID:medline
+
+<516>
+Unique Identifier
+ 35422766
+Title
+ The Effects of 12-Weeks Whey Protein Supplements on Markers of Bone Turnover in Adults With Abdominal Obesity - A Post Hoc Analysis.
+Source
+ Frontiers in Endocrinology. 13:832897, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fuglsang-Nielsen R; Rakvaag E; Vestergaard P; Hermansen K; Gregersen S; Starup-Linde J
+Authors Full Name
+ Fuglsang-Nielsen, Rasmus; Rakvaag, Elin; Vestergaard, Peter; Hermansen, Kjeld; Gregersen, Soren; Starup-Linde, Jakob.
+Institution
+ Fuglsang-Nielsen, Rasmus. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
+ Fuglsang-Nielsen, Rasmus. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
+ Rakvaag, Elin. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
+ Vestergaard, Peter. Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark.
+ Vestergaard, Peter. Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
+ Vestergaard, Peter. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
+ Hermansen, Kjeld. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
+ Hermansen, Kjeld. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
+ Gregersen, Soren. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
+ Gregersen, Soren. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
+ Starup-Linde, Jakob. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
+ Starup-Linde, Jakob. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Bone Remodeling
+ Calcium/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ Dietary Fiber/pd [Pharmacology]
+ Humans
+ *Insulin Resistance
+ Obesity
+ Obesity, Abdominal/co [Complications]
+ Parathyroid Hormone
+ Urea/pd [Pharmacology]
+ Whey Proteins/pd [Pharmacology]
+Keyword Heading
+ abdominal obesity
+ bone turnover
+ dietary fiber
+ dietary protein
+ insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: While osteoporosis is characterized by skeletal fragility due to increased bone turnover and low bone mineral density (BMD), subjects with abdominal obesity and type-2 diabetes have increased risk of bone fractures despite low bone turnover and increased BMD. Diets with increased protein content are reported to increase bone turnover in healthy adults and may be a point of interest in preserving bone strength in subjects with abdominal obesity and/or type-2 diabetes.
+
+ Methods: We examined the effect of 12-weeks dietary intervention on bone turnover in 64 adults with abdominal obesity using data from the MERITS trial. The trial was a randomized, controlled, double blinded study in which participants were allocated to receive either 60 g/d of whey protein hydrolysate or maltodextrin in combination with either high (30 g/d) or low dietary fiber intake (10 g/d). Primarily, we assessed changes in plasma markers of bone turnover Procollagen type 1 N-terminal propeptide (p1NP), C-terminal telopeptide type-1 collagen (CTX), and parathyroid hormone (PTH) within the four intervention groups. In addition, we measured u-calcium and u-carbamide excretion, 25(OH)D, and BMD by whole body DXA scans. Finally, we compared changes in insulin resistance (Homeostasis-model assessment of insulin resistance, HOMA-IR) with changes in bone turnover markers. The trial was registered at www.clinicaltrials.gov as NCT02931630.
+
+ Results: Sixty-four subjects were included in the study. We did not find any effect of twelve weeks of high protein or high fiber intake on plasma levels of P1NP or CTX. There was a nonsignificant positive association between protein intake and PTH levels (p=0.06). U-calcium and u-carbamide increased in both protein groups. There was a positive association between change in HOMA-IR and PTH (p=0.042), while changes in P1NP and CTX did not associate to changes in HOMA-IR.
+
+ Conclusion: Twelve weeks of increased whey protein intake in subjects with abdominal obesity did not affect markers of bone turnover significantly, although tended to increase PTH levels. Dietary fiber intake did not affect bone turnover. We report a positive association between change in HOMA-IR and PTH supporting a hypothesis of insulin resistance as a potential key factor in the expanding field of bone fragility in T2D subjects. Copyright © 2022 Fuglsang-Nielsen, Rakvaag, Vestergaard, Hermansen, Gregersen and Starup-Linde.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fiber). 0 (Parathyroid Hormone). 0 (Whey Proteins). 8W8T17847W (Urea). SY7Q814VUP (Calcium).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3389%2ffendo.2022.832897
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fuglsang-Nielsen&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=The+Effects+of+12-Weeks+Whey+Protein+Supplements+on+Markers+of+Bone+Turnover+in+Adults+With+Abdominal+Obesity+-+A+Post+Hoc+Analysis.&volume=13&issue=&spage=832897&epage=&date=2022&doi=10.3389%2Ffendo.2022.832897&pmid=35422766&sid=OVID:medline
+
+<517>
+Unique Identifier
+ 35421322
+Title
+ The impact of obesity on the regulation of muscle blood flow during exercise in patients with heart failure with a preserved ejection fraction.
+Source
+ Journal of Applied Physiology. 132(5):1240-1249, 2022 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ratchford SM; Lee JF; Bunsawat K; Alpenglow JK; Zhao J; Ma CL; Ryan JJ; Khor LL; Wray DW
+Author NameID
+ Ratchford, Stephen M; ORCID: https://orcid.org/0000-0002-6300-7600
+ Bunsawat, Kanokwan; ORCID: https://orcid.org/0000-0002-5950-6634
+ Wray, D Walter; ORCID: https://orcid.org/0000-0002-6907-1734
+Authors Full Name
+ Ratchford, Stephen M; Lee, Joshua F; Bunsawat, Kanokwan; Alpenglow, Jeremy K; Zhao, Jia; Ma, Christy L; Ryan, John J; Khor, Lillian L; Wray, D Walter.
+Institution
+ Ratchford, Stephen M. Geriatric Research, Education, and Clinical Center, George E. Wahlen VA Medical Center, Salt Lake City, Utah.
+ Ratchford, Stephen M. Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah.
+ Lee, Joshua F. Geriatric Research, Education, and Clinical Center, George E. Wahlen VA Medical Center, Salt Lake City, Utah.
+ Lee, Joshua F. Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah.
+ Bunsawat, Kanokwan. Geriatric Research, Education, and Clinical Center, George E. Wahlen VA Medical Center, Salt Lake City, Utah.
+ Bunsawat, Kanokwan. Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah.
+ Alpenglow, Jeremy K. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah.
+ Zhao, Jia. Geriatric Research, Education, and Clinical Center, George E. Wahlen VA Medical Center, Salt Lake City, Utah.
+ Ma, Christy L. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
+ Ryan, John J. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
+ Khor, Lillian L. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
+ Wray, D Walter. Geriatric Research, Education, and Clinical Center, George E. Wahlen VA Medical Center, Salt Lake City, Utah.
+ Wray, D Walter. Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah.
+ Wray, D Walter. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah.
+MeSH Subject Headings
+ Biomarkers
+ Hand Strength
+ *Heart Failure
+ Hemodynamics
+ Humans
+ Inflammation
+ Interleukin-6
+ Muscle, Skeletal
+ Obesity
+ Stroke Volume/ph [Physiology]
+Keyword Heading
+ exercise hyperemia
+ heart failure
+ inflammation
+ preserved ejection fraction
+ vasodilation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is now considered a primary comorbidity in heart failure with preserved ejection fraction (HFpEF) pathophysiology, mediated largely by systemic inflammation. Although there is accumulating evidence for a disease-related dysregulation of blood flow during exercise in this patient group, the role of obesity in the hemodynamic response to exercise remains largely unknown. Small muscle mass handgrip (HG) exercise was used to evaluate exercising muscle blood flow in nonobese (BMI < 30 kg/m2, n = 14) and obese (BMI > 30 kg/m2, n = 40) patients with HFpEF. Heart rate (HR), stroke index (SI), cardiac index (CI), mean arterial pressure (MAP), forearm blood flow (FBF), and vascular conductance (FVC) were assessed during progressive intermittent HG exercise [15%-30%-45% maximal voluntary contraction (MVC)]. Blood biomarkers of inflammation [C-reactive protein (CRP) and interleukin-6 (IL-6)] were also determined. Exercising FBF was reduced in obese patients with HFpEF at all work rates (15%: 304 +/- 42 vs. 229 +/- 15 mL/min; 30%: 402 +/- 46 vs. 300 +/- 18 mL/min; 45%: 484 +/- 55 vs. 380 +/- 23 mL/min, nonobese vs. obese, P = 0.025), and was negatively correlated with BMI (R = -0.47, P < 0.01). In contrast, no differences in central hemodynamics (HR, SI, CI, and MAP) were found between groups. Proinflammatory biomarkers were markedly elevated in patients with obesity (CRP: 2,133 +/- 418 vs. 4,630 +/- 590 ng/mL, P = 0.02; IL-6: 2.9 +/- 0.3 vs. 5.2 +/- 0.7 pg/mL, nonobese vs. obese, P = 0.04), and both biomarkers were positively correlated with BMI (CRP: R = 0.40, P = 0.03; IL-6: R = 0.57, P < 0.01). Together, these findings demonstrate the presence of obesity and an accompanying milieu of systemic inflammation as important factors in the dysregulation of exercising muscle blood flow in patients with HFpEF. NEW & NOTEWORTHY Obesity is the primary comorbid condition in HFpEF pathophysiology, but the role of adiposity on the peripheral circulation is not well understood. The present study identified a 30%-40% reduction in forearm blood flow during handgrip exercise, accompanied by a marked elevation in proinflammatory plasma biomarkers, in obese patients with HFpEF compared with their nonobese counterparts. These findings suggest an exaggerated dysregulation in exercising muscle blood flow associated with the obese HFpEF phenotype.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1152%2fjapplphysiol.00833.2021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ratchford&issn=0161-7567&title=Journal+of+Applied+Physiology&atitle=The+impact+of+obesity+on+the+regulation+of+muscle+blood+flow+during+exercise+in+patients+with+heart+failure+with+a+preserved+ejection+fraction.&volume=132&issue=5&spage=1240&epage=1249&date=2022&doi=10.1152%2Fjapplphysiol.00833.2021&pmid=35421322&sid=OVID:medline
+
+<518>
+Unique Identifier
+ 35417923
+Title
+ Role of non-coding RNAs on liver metabolism and NAFLD pathogenesis. [Review]
+Source
+ Human Molecular Genetics. 31(R1):R4-R21, 2022 10 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Qian G; Morral N
+Author NameID
+ Morral, Nuria; ORCID: https://orcid.org/0000-0002-8932-2887
+Authors Full Name
+ Qian, Gene; Morral, Nuria.
+Institution
+ Qian, Gene. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
+ Morral, Nuria. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
+ Morral, Nuria. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
+MeSH Subject Headings
+ Animals
+ Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Insulin Resistance/ge [Genetics]
+ *Insulin Resistance
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2
+ RNA, Circular
+ Liver/me [Metabolism]
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ Obesity/co [Complications]
+ Biomarkers/me [Metabolism]
+ Lipoproteins, VLDL/me [Metabolism]
+ Glucose/me [Metabolism]
+ Liver Cirrhosis/me [Metabolism]
+Abstract
+ Obesity and type 2 diabetes are major contributors to the growing prevalence of non-alcoholic fatty liver disease (NAFLD), a chronic liver condition characterized by the accumulation of fat in individuals without a significant amount of alcohol intake. The NAFLD spectrum ranges from simple steatosis (early stages, known as NAFL) to non-alcoholic steatohepatitis, which can progress to fibrosis and cirrhosis or hepatocellular carcinoma. Obesity, type 2 diabetes and NAFLD are strongly associated with insulin resistance. In the liver, insulin resistance increases hepatic glucose output, lipogenesis and very-low-density lipoprotein secretion, leading to a combination of hyperglycemia and hypertriglyceridemia. Aberrant gene expression is a hallmark of insulin resistance. Non-coding RNAs (ncRNAs) have emerged as prominent regulators of gene expression that operate at the transcriptional, post-transcriptional and post-translational levels. In the last couple of decades, a wealth of studies have provided evidence that most processes of liver metabolism are orchestrated by ncRNAs. This review focuses on the role of microRNAs, long non-coding RNAs and circular RNAs as coordinators of hepatic function, as well as the current understanding on how their dysregulation contributes to abnormal metabolism and pathophysiology in animal models of insulin resistance and NAFLD. Moreover, ncRNAs are emerging as useful biomarkers that may be able to discriminate between the different stages of NAFLD. The potential of ncRNAs as therapeutic drugs for NAFLD treatment and as biomarkers is discussed. Copyright © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (RNA, Circular). 0 (MicroRNAs). 0 (Biomarkers). 0 (Lipoproteins, VLDL). IY9XDZ35W2 (Glucose).
+Publication Type
+ Review. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1093%2fhmg%2fddac088
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Qian&issn=0964-6906&title=Human+Molecular+Genetics&atitle=Role+of+non-coding+RNAs+on+liver+metabolism+and+NAFLD+pathogenesis.&volume=31&issue=1&spage=R4&epage=R21&date=2022&doi=10.1093%2Fhmg%2Fddac088&pmid=35417923&sid=OVID:medline
+
+<519>
+Unique Identifier
+ 35416190
+Title
+ The effect of hydroxy citric acid supplementation with calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in women with non-alcoholic fatty liver disease: a randomized controlled clinical trial.
+Source
+ Food & Function. 13(9):5124-5134, 2022 May 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Arefhosseini S; Tutunchi H; Nomi-Golzar S; Mahboob S; Pouretedal Z; Ebrahimi-Mameghani M
+Author NameID
+ Tutunchi, Helda; ORCID: http://orcid.org/0000-0002-4795-1757
+ Ebrahimi-Mameghani, Mehrangiz; ORCID: http://orcid.org/0000-0002-0311-1289
+Authors Full Name
+ Arefhosseini, Sara; Tutunchi, Helda; Nomi-Golzar, Solmaz; Mahboob, Soltanali; Pouretedal, Zohre; Ebrahimi-Mameghani, Mehrangiz.
+Institution
+ Arefhosseini, Sara. Student Research Committee, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Tutunchi, Helda. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Nomi-Golzar, Solmaz. Student Research Committee, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Mahboob, Soltanali. Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. ebrahimimamagani@tbzmed.ac.ir.
+ Pouretedal, Zohre. Standard Research Institute, Food Technology and Agricultural Products Research Center, Microbiology and Biology Group, Tehran, Iran.
+ Ebrahimi-Mameghani, Mehrangiz. Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. ebrahimimamagani@tbzmed.ac.ir.
+MeSH Subject Headings
+ Atherosclerosis/dt [Drug Therapy]
+ *Atherosclerosis
+ Biomarkers
+ Caloric Restriction
+ Cholesterol
+ Cholesterol, HDL
+ Cholesterol, LDL
+ Citric Acid
+ Dietary Supplements
+ Female
+ Humans
+ Hydroxy Acids
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/dt [Drug Therapy]
+ Triglycerides
+Abstract
+ The objective of the present study was to examine the effects of hydroxy citric acid (HCA) extracts from Garcinia cambogia on metabolic, atherogenic and inflammatory biomarkers in obese women with non-alcoholic fatty liver disease (NAFLD). The present clinical trial was carried out on 40 overweight/obese women with NAFLD. The patients were randomly allocated into either the "HCA group" (receiving calorie-restricted diet (-700 kcal d-1) accompanied by HCA tablets) and the "control group" (receiving only calorie-restricted diet) for eight weeks. Weight, height, body mass index (BMI), and waist circumference (WC) were measured. Fasting blood sugar (FBS), lipid profile, liver enzymes, as well as inflammatory biomarkers were determined at baseline and after the intervention. Dietary intake was assessed at baseline and at the end of the trial and food intake data were analyzed by the Nutritionist IV software. Results showed a decrease in energy and macronutrient intake in both groups (p < 0.05). Weight, BMI, WC, and hip circumference as well as FBS, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) decreased and high-density lipoprotein cholesterol (HDL-C) increased significantly in the HCA group (p < 0.05). There were also significant reductions in WC, FBS, TG, total cholesterol, LDL-C in the control group while inter-group changes in FBS, TG, LDL-C and HDL-C were statistically significant. Although atherogenic indices reduced significantly in both groups, inter-group comparison revealed that the HCA group showed greater decrease in the TG/HDL-C ratio than the control group (p = 0.004). Other atherogenic indices including TC/HDL-C and non-HDL-C/HDL-C ratio showed greater reduction in the control versus HCA group (p < 0.01). Some inflammatory factors were reduced in the HCA group; however, no significant within- or between-group differences were revealed post-intervention. Our results indicated that HCA supplementation plus calorie-restricted diet could improve some metabolic factors without any significant effect on inflammation in patients with NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Hydroxy Acids). 0 (Triglycerides). 2968PHW8QP (Citric Acid). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1039%2fd1fo03685h
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Arefhosseini&issn=2042-6496&title=Food+%26+Function&atitle=The+effect+of+hydroxy+citric+acid+supplementation+with+calorie-restricted+diet+on+metabolic%2C+atherogenic+and+inflammatory+biomarkers+in+women+with+non-alcoholic+fatty+liver+disease%3A+a+randomized+controlled+clinical+trial.&volume=13&issue=9&spage=5124&epage=5134&date=2022&doi=10.1039%2Fd1fo03685h&pmid=35416190&sid=OVID:medline
+
+<520>
+Unique Identifier
+ 35413837
+Title
+ Plasma and fecal zonulin are not altered by a high green leafy vegetable dietary intervention: secondary analysis of a randomized control crossover trial.
+Source
+ BMC Gastroenterology. 22(1):184, 2022 Apr 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Riviere AJ; Smith KS; Schaberg MN; Greene MW; Fruge AD
+Authors Full Name
+ Riviere, Aaron J; Smith, Kristen S; Schaberg, Megan N; Greene, Michael W; Fruge, Andrew D.
+Institution
+ Riviere, Aaron J. Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, 36849, USA. ajriviere@tamu.edu.
+ Riviere, Aaron J. Department of Health and Kinesiology, Texas A&M University, College Station, TX, 77843, USA. ajriviere@tamu.edu.
+ Smith, Kristen S. Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, 36849, USA.
+ Schaberg, Megan N. Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, 36849, USA.
+ Greene, Michael W. Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, 36849, USA.
+ Fruge, Andrew D. Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, 36849, USA.
+MeSH Subject Headings
+ 8-Hydroxy-2'-Deoxyguanosine/bl [Blood]
+ 8-Hydroxy-2'-Deoxyguanosine/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Cross-Over Studies
+ Feces
+ Female
+ Haptoglobins/me [Metabolism]
+ *Haptoglobins
+ Humans
+ *Inflammation
+ Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ *Obesity
+ Protein Precursors/bl [Blood]
+ Protein Precursors/me [Metabolism]
+ *Protein Precursors
+ Randomized Controlled Trials as Topic
+ *Vegetables
+ Vitamin K
+Keyword Heading
+ Diet
+ Intestinal permeability
+ Microbiome
+ Zonulin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Zonulin is observed in animal models to regulate intestinal permeability and influenced by dietary intake, gut microbiota, and inflammation. We conducted a secondary analysis of a randomized controlled crossover trial (NCT03582306) in individuals with a BMI greater than 30 kg/m2 and high habitual red meat intake and low habitual green leafy vegetable (GLV) intake.
+
+ METHODS: Participants were provided with frozen GLV during the first or last four weeks (immediate or delayed intervention) of the twelve-week trial. Biological and anthropometric measures were taken at the beginning and at each four-week interval. A subset of 20 participants was selected for this secondary analysis of the intestinal permeability and inflammation-related biomarkers: serum and fecal zonulin; serum lipopolysaccharide binding protein (LBP), Alpha-1-acid glycoprotein 1 (ORM-1), tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), and C-reactive protein; 8-hydroxy-2'-deoxyguanosine (8OHdG) and plasma Vitamin K1 as a marker of protocol adherence. Nutrient and food group intake from two-24-h dietary recalls collected at each time point were assessed. Fecal microbiota was measured by 16 s rRNA PCR sequencing. Changes in biological markers, dietary factors, and microbial taxa were assessed with Wilcoxon Sign Ranks Tests. Exploratory analyses of the relationship between changes in outcome variables were conducted with Spearman correlations.
+
+ RESULTS: No changes in serum and fecal zonulin and serum LBP were observed. Plasma Vitamin K (p = 0.005) increased, while plasma 8OHdG (p = 0.023) decreased during the intervention compared to the control. The only dietary factors that changed significantly were increases during intervention in Vitamin K and Dark GLV (p < 0.001 for both) compared to control. Fecal microbiota did not change significantly across all times points; however, change in serum zonulin was associated with change in Proteobacteria (rho = - 0.867, p = 0.001) in females and Bifidobacterium (rho = - 0.838, p = 0.009) and Bacteroidaceae (rho = 0.871, p = 0.005) in men.
+
+ CONCLUSIONS: A high GLV dietary intervention increased serum zonulin levels and had no effect on fecal zonulin. Lack of concordance between several inflammation-associated biomarkers and zonulin corroborate recent reports of limited utility of zonulin in obese adults free of lower gastrointestinal disease. Trial Registration information: https://clinicaltrials.gov/ct2/show/NCT03582306 (NCT03582306) registered on 07/11/2018. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Haptoglobins). 0 (Protein Precursors). 0 (zonulin). 12001-79-5 (Vitamin K). 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.1186%2fs12876-022-02248-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Riviere&issn=1471-230X&title=BMC+Gastroenterology&atitle=Plasma+and+fecal+zonulin+are+not+altered+by+a+high+green+leafy+vegetable+dietary+intervention%3A+secondary+analysis+of+a+randomized+control+crossover+trial.&volume=22&issue=1&spage=184&epage=&date=2022&doi=10.1186%2Fs12876-022-02248-3&pmid=35413837&sid=OVID:medline
+
+<521>
+Unique Identifier
+ 35410857
+Title
+ Fibroblast Growth Factor 21 as a Marker of Prediabetes in Patients with Non-alcoholic Fatty Liver Disease.
+Source
+ Turkish Journal of Gastroenterology. 33(3):233-239, 2022 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karamfilova V; Assyov Y; Nedeva I; Gateva A; Ivanova I; Cherkezov I; Mateva L; Kamenov Z
+Authors Full Name
+ Karamfilova, Vera; Assyov, Yavor; Nedeva, Iveta; Gateva, Antoaneta; Ivanova, Irena; Cherkezov, Ivanova; Mateva, Ludmila; Kamenov, Zdravko.
+Institution
+ Karamfilova, Vera. Department of Internal Medicine, Clinic of Endocrinology and Metabolic Diseases, University Hospital "Alexandrovska", Medical University of Sofia, Sofia, Bulgaria.
+ Assyov, Yavor. Department of Internal Medicine, Clinic of Endocrinology and Metabolic Diseases, University Hospital "Alexandrovska", Medical University of Sofia, Sofia, Bulgaria.
+ Nedeva, Iveta. Department of Internal Medicine, Clinic of Endocrinology and Metabolic Diseases, University Hospital "Alexandrovska", Medical University of Sofia, Sofia, Bulgaria.
+ Gateva, Antoaneta. Department of Internal Medicine, Clinic of Endocrinology and Metabolic Diseases, University Hospital "Alexandrovska", Medical University of Sofia, Sofia, Bulgaria.
+ Ivanova, Irena. Clinical Laboratory Department, University Hospital "St. Ivan Rilski", Medical University of Sofia, Sofia, Bulgaria.
+ Cherkezov, Ivanova. Medical Faculty, Medical University of Sofia, Sofia, Bulgaria.
+ Mateva, Ludmila. Department of Internal Medicine, Clinic of Gastroenterology, University Hospital "St. Ivan Rilski", Medical University of Sofia, Sofia, Bulgaria.
+ Kamenov, Zdravko. Department of Internal Medicine, Clinic of Endocrinology and Metabolic Diseases, University Hospital "Alexandrovska", Medical University of Sofia, Sofia, Bulgaria.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ *Fibroblast Growth Factors/bl [Blood]
+ Humans
+ *Insulin Resistance
+ Metabolic Syndrome/co [Complications]
+ *Metabolic Syndrome
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Prediabetic State/co [Complications]
+ Prediabetic State/ep [Epidemiology]
+ *Prediabetic State
+Abstract
+ BACKGROUND: Fibroblast growth factor 21 is a peptide primarily secreted by the liver in response to peroxisome proliferator-activated receptor-alpha activation which plays an important role in regulating carbohydrate and lipid metabolism. This study investigated the association between fibroblast growth factor 21 and prediabetes in obese patients with non-alcoholic fatty liver disease in adult population.
+
+ METHODS: A total of 85 obese non-alcoholic fatty liver disease patients without (n = 49) and with prediabetes (n = 36) were included. Serum fibroblast growth factor 21 levels were determined by enzyme-linked immunosorbent assay.
+
+ RESULTS: Higher fibroblast growth factor 21 serum levels were observed in patients with prediabetes, metabolic syndrome, dyslipidemia, and insulin resistance. There were significant correlations between fibroblast growth factor 21 and waist-to-stature ratio, visceral adiposity index, triglycerides, very low-density lipoproteins, alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), Quantitative Insulin Sensitivity Check Index, and Stumvoll index of insulin sensitivity. Fibroblast growth factor 21 level >=320 pg/mL was associated with a 4.2-fold higher risk of prediabetes and >=270 pg/mL for metabolic syndrome approximately 4 times.
+
+ CONCLUSION: Fibroblast growth factor 21 is associated with increased risk for prediabetes, metabolic syndrome, and insulin resistance in obese patients with non-alcoholic fatty liver disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FGF21 protein, human). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.5152%2ftjg.2021.201165
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karamfilova&issn=1300-4948&title=Turkish+Journal+of+Gastroenterology&atitle=Fibroblast+Growth+Factor+21+as+a+Marker+of+Prediabetes+in+Patients+with+Non-alcoholic+Fatty+Liver+Disease.&volume=33&issue=3&spage=233&epage=239&date=2022&doi=10.5152%2Ftjg.2021.201165&pmid=35410857&sid=OVID:medline
+
+<522>
+Unique Identifier
+ 35409324
+Title
+ Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice.
+Source
+ International Journal of Molecular Sciences. 23(7), 2022 Apr 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Opazo-Rios L; Soto-Catalan M; Lazaro I; Sala-Vila A; Jimenez-Castilla L; Orejudo M; Moreno JA; Egido J; Mas-Fontao S
+Author NameID
+ Opazo-Rios, Lucas; ORCID: https://orcid.org/0000-0003-3586-3319
+ Soto-Catalan, Manuel; ORCID: https://orcid.org/0000-0003-3500-4637
+ Lazaro, Iolanda; ORCID: https://orcid.org/0000-0002-6172-9845
+ Sala-Vila, Aleix; ORCID: https://orcid.org/0000-0002-5038-2794
+ Moreno, Juan Antonio; ORCID: https://orcid.org/0000-0002-7468-2871
+ Mas-Fontao, Sebastian; ORCID: https://orcid.org/0000-0001-6604-3327
+Authors Full Name
+ Opazo-Rios, Lucas; Soto-Catalan, Manuel; Lazaro, Iolanda; Sala-Vila, Aleix; Jimenez-Castilla, Luna; Orejudo, Macarena; Moreno, Juan Antonio; Egido, Jesus; Mas-Fontao, Sebastian.
+Institution
+ Opazo-Rios, Lucas. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Opazo-Rios, Lucas. Facultad de Ciencias de la Salud, Universidad de Las Americas, Concepcion-Talcahuano 4301099, Chile.
+ Soto-Catalan, Manuel. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Lazaro, Iolanda. Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.
+ Sala-Vila, Aleix. Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.
+ Jimenez-Castilla, Luna. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Orejudo, Macarena. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Moreno, Juan Antonio. Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain.
+ Moreno, Juan Antonio. Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofia, 14004 Cordoba, Spain.
+ Egido, Jesus. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Mas-Fontao, Sebastian. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Disease Progression
+ Fatty Liver/me [Metabolism]
+ *Fatty Liver
+ Inflammation/pa [Pathology]
+ Lipids
+ *Lipogenesis
+ Liver/me [Metabolism]
+ Mice
+ Mice, Inbred C57BL
+ Mice, Inbred Strains
+ Mice, Obese
+ Obesity/me [Metabolism]
+Keyword Heading
+ BTBR ob/ob
+ de novo lipogenesis
+ meta-inflammation
+ metabolic associated fatty liver disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Metabolic associated fatty liver disease (MAFLD) is a hepatic manifestation of metabolic syndrome and usually associated with obesity and diabetes. Our aim is to characterize the pathophysiological mechanism involved in MAFLD development in Black Tan and brachyuric (BTBR) insulin-resistant mice in combination with leptin deficiency (ob/ob). We studied liver morphology and biochemistry on our diabetic and obese mice model (BTBR ob/ob) as well as a diabetic non-obese control (BTBR + streptozotocin) and non-diabetic control mice (BTBR wild type) from 4-22 weeks. Lipid composition was assessed, and lipid related pathways were studied at transcriptional and protein level. Microvesicular steatosis was evident in BTBR ob/ob from week 6, progressing to macrovesicular in the following weeks. At 12th week, inflammatory clusters, activation of STAT3 and Nrf2 signaling pathways, and hepatocellular ballooning. At 22 weeks, the histopathological features previously observed were maintained and no signs of fibrosis were detected. Lipidomic analysis showed profiles associated with de novo lipogenesis (DNL). BTBR ob/ob mice develop MAFLD profile that resemble pathological features observed in humans, with overactivation of inflammatory response, oxidative stress and DNL signaling pathways. Therefore, BTBR ob/ob mouse is an excellent model for the study of the steatosis to steatohepatitis transition.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms23073965
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Opazo-Rios&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Meta-Inflammation+and+De+Novo+Lipogenesis+Markers+Are+Involved+in+Metabolic+Associated+Fatty+Liver+Disease+Progression+in+BTBR+ob%2Fob+Mice.&volume=23&issue=7&spage=3965&epage=&date=2022&doi=10.3390%2Fijms23073965&pmid=35409324&sid=OVID:medline
+
+<523>
+Unique Identifier
+ 35409168
+Title
+ A Wide-Proteome Analysis to Identify Molecular Pathways Involved in Kidney Response to High-Fat Diet in Mice.
+Source
+ International Journal of Molecular Sciences. 23(7), 2022 Mar 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dozio E; Maffioli E; Vianello E; Nonnis S; Grassi Scalvini F; Spatola L; Roccabianca P; Tedeschi G; Corsi Romanelli MM
+Author NameID
+ Dozio, Elena; ORCID: https://orcid.org/0000-0001-5833-0780
+ Maffioli, Elisa; ORCID: https://orcid.org/0000-0002-5539-1825
+ Nonnis, Simona; ORCID: https://orcid.org/0000-0002-3453-7282
+ Spatola, Leonardo; ORCID: https://orcid.org/0000-0002-8883-4776
+ Roccabianca, Paola; ORCID: https://orcid.org/0000-0002-3672-4612
+ Corsi Romanelli, Massimiliano Marco; ORCID: https://orcid.org/0000-0001-7928-7697
+Authors Full Name
+ Dozio, Elena; Maffioli, Elisa; Vianello, Elena; Nonnis, Simona; Grassi Scalvini, Francesca; Spatola, Leonardo; Roccabianca, Paola; Tedeschi, Gabriella; Corsi Romanelli, Massimiliano Marco.
+Institution
+ Dozio, Elena. Laboratory of Clinical Pathology, Department of Biomedical Sciences for Health, Universita degli Studi di Milano, 20133 Milan, Italy.
+ Maffioli, Elisa. Department of Veterinary Medicine and Animal Science, Universita degli Studi di Milano, 26900 Lodi, Italy.
+ Vianello, Elena. Laboratory of Clinical Pathology, Department of Biomedical Sciences for Health, Universita degli Studi di Milano, 20133 Milan, Italy.
+ Nonnis, Simona. Department of Veterinary Medicine and Animal Science, Universita degli Studi di Milano, 26900 Lodi, Italy.
+ Nonnis, Simona. CRC "Innovation for Well-Being and Environment" (I-WE), Universita degli Studi di Milano, 29133 Milan, Italy.
+ Grassi Scalvini, Francesca. Department of Veterinary Medicine and Animal Science, Universita degli Studi di Milano, 26900 Lodi, Italy.
+ Spatola, Leonardo. Division of Nephrology, Dialysis and Renal Transplantation, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy.
+ Roccabianca, Paola. Department of Veterinary Medicine and Animal Science, Universita degli Studi di Milano, 26900 Lodi, Italy.
+ Tedeschi, Gabriella. Department of Veterinary Medicine and Animal Science, Universita degli Studi di Milano, 26900 Lodi, Italy.
+ Tedeschi, Gabriella. CRC "Innovation for Well-Being and Environment" (I-WE), Universita degli Studi di Milano, 29133 Milan, Italy.
+ Corsi Romanelli, Massimiliano Marco. Laboratory of Clinical Pathology, Department of Biomedical Sciences for Health, Universita degli Studi di Milano, 20133 Milan, Italy.
+ Corsi Romanelli, Massimiliano Marco. Service of Laboratory Medicine1-Clinical Pathology, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ Fibrosis
+ Kidney/me [Metabolism]
+ Lipids
+ Liver/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/me [Metabolism]
+ Proteome/me [Metabolism]
+ Proteomics
+ Renal Insufficiency, Chronic/me [Metabolism]
+ *Renal Insufficiency, Chronic
+Keyword Heading
+ cardiometabolic risk
+ fibrosis
+ high-fat diet
+ kidney
+ lipids
+ obesity
+ proteomic analysis
+ renal damage
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The etiopathogenesis of obesity-related chronic kidney disease (CKD) is still scarcely understood. To this aim, we assessed the effect of high-fat diet (HF) on molecular pathways leading to organ damage, steatosis, and fibrosis. Six-week-old male C57BL/6N mice were fed HF diet or normal chow for 20 weeks. Kidneys were collected for genomic, proteomic, histological studies, and lipid quantification. The main findings were as follows: (1) HF diet activated specific pathways leading to fibrosis and increased fatty acid metabolism; (2) HF diet promoted a metabolic shift of lipid metabolism from peroxisomes to mitochondria; (3) no signs of lipid accumulation and/or fibrosis were observed, histologically; (4) the early signs of kidney damage seemed to be related to changes in membrane protein expression; (5) the proto-oncogene MYC was one of the upstream transcriptional regulators of changes occurring in protein expression. These results demonstrated the potential usefulness of specific selected molecules as early markers of renal injury in HF, while histomorphological changes become visible later in obesity-related CDK. The integration of these information with data from biological fluids could help the identification of biomarkers useful for the early detection and prevention of tissue damage in clinical practice.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 0 (Proteome).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms23073809
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dozio&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=A+Wide-Proteome+Analysis+to+Identify+Molecular+Pathways+Involved+in+Kidney+Response+to+High-Fat+Diet+in+Mice.&volume=23&issue=7&spage=3809&epage=&date=2022&doi=10.3390%2Fijms23073809&pmid=35409168&sid=OVID:medline
+
+<524>
+Unique Identifier
+ 35409085
+Title
+ Sprague Dawley Rats Show More Severe Bone Loss, Osteophytosis and Inflammation Compared toWistar Han Rats in a High-Fat, High-Sucrose Diet Model of Joint Damage.
+Source
+ International Journal of Molecular Sciences. 23(7), 2022 Mar 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Warmink K; Rios JL; van Valkengoed DR; Korthagen NM; Weinans H
+Author NameID
+ Warmink, Kelly; ORCID: https://orcid.org/0000-0003-4131-675X
+ Rios, Jaqueline L; ORCID: https://orcid.org/0000-0002-3679-2869
+ Korthagen, Nicoline M; ORCID: https://orcid.org/0000-0002-9277-0795
+ Weinans, Harrie; ORCID: https://orcid.org/0000-0002-2275-6170
+Authors Full Name
+ Warmink, Kelly; Rios, Jaqueline L; van Valkengoed, Devin R; Korthagen, Nicoline M; Weinans, Harrie.
+Institution
+ Warmink, Kelly. Department of Orthopaedics, University Medical Center Utrecht (UMCU), P.O. Box 85500, 3584 GA Utrecht, The Netherlands.
+ Rios, Jaqueline L. Department of Orthopaedics, University Medical Center Utrecht (UMCU), P.O. Box 85500, 3584 GA Utrecht, The Netherlands.
+ van Valkengoed, Devin R. Department of Orthopaedics, University Medical Center Utrecht (UMCU), P.O. Box 85500, 3584 GA Utrecht, The Netherlands.
+ Korthagen, Nicoline M. Department of Orthopaedics, University Medical Center Utrecht (UMCU), P.O. Box 85500, 3584 GA Utrecht, The Netherlands.
+ Korthagen, Nicoline M. Department of Equine Sciences, Utrecht University, P.O. Box 80125, 3584 CS Utrecht, The Netherlands.
+ Weinans, Harrie. Department of Orthopaedics, University Medical Center Utrecht (UMCU), P.O. Box 85500, 3584 GA Utrecht, The Netherlands.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Inflammation
+ Obesity/me [Metabolism]
+ Osteoarthritis/dg [Diagnostic Imaging]
+ Osteoarthritis/et [Etiology]
+ Osteoarthritis/pa [Pathology]
+ *Osteoarthritis
+ Rats
+ Rats, Sprague-Dawley
+ Rats, Wistar
+ Sucrose/ae [Adverse Effects]
+ *Sucrose
+Keyword Heading
+ animal models
+ obesity
+ osteoarthritis
+ osteoporosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In animal models, joint degeneration observed in response to obesogenic diet varies in nature and severity. In this study, we compare joint damage in Sprague Dawley and Wistar-Han rats in response to a high-fat, high-sucrose (HFS) diet groove model of osteoarthritis (OA). Wistar Han (n = 5) and Sprague Dawley (n = 5) rats were fed an HFS diet for 24 weeks. OA was induced 12 weeks after the diet onset by groove surgery in the right knee joint. The left knee served as a control. Outcomes were OARSI histopathology scoring, bone changes by microCT imaging, local (synovial and fat pad) and systemic (blood cytokine) inflammation markers. In both rat strains, the HFS diet resulted in a similar change in metabolic parameters, but only Sprague Dawley rats showed a large, osteoporosis-like decrease in trabecular bone volume. Osteophyte count and local joint inflammation were higher in Sprague Dawley rats. In contrast, cartilage degeneration and systemic inflammatory marker levels were similar between the rat strains. The difference in bone volume loss, osteophytosis and local inflammation suggest that both rat strains show a different joint damage phenotype and could, therefore, potentially represent different OA phenotypes observed in humans.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 57-50-1 (Sucrose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fijms23073725
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Warmink&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Sprague+Dawley+Rats+Show+More+Severe+Bone+Loss%2C+Osteophytosis+and+Inflammation+Compared+toWistar+Han+Rats+in+a+High-Fat%2C+High-Sucrose+Diet+Model+of+Joint+Damage.&volume=23&issue=7&spage=3725&epage=&date=2022&doi=10.3390%2Fijms23073725&pmid=35409085&sid=OVID:medline
+
+<525>
+Unique Identifier
+ 35406052
+Title
+ Changes in Kidney Fat upon Dietary-Induced Weight Loss.
+Source
+ Nutrients. 14(7), 2022 Mar 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Spurny M; Jiang Y; Sowah SA; Nonnenmacher T; Schubel R; Kirsten R; Johnson T; von Stackelberg O; Ulrich CM; Kaaks R; Kauczor HU; Kuhn T; Nattenmuller J
+Author NameID
+ Jiang, Yixin; ORCID: https://orcid.org/0000-0001-8504-0500
+ Kauczor, Hans-Ulrich; ORCID: https://orcid.org/0000-0002-6730-9462
+Authors Full Name
+ Spurny, Manuela; Jiang, Yixin; Sowah, Solomon A; Nonnenmacher, Tobias; Schubel, Ruth; Kirsten, Romy; Johnson, Theron; von Stackelberg, Oyunbileg; Ulrich, Cornelia M; Kaaks, Rudolf; Kauczor, Hans-Ulrich; Kuhn, Tilman; Nattenmuller, Johanna.
+Institution
+ Spurny, Manuela. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
+ Jiang, Yixin. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
+ Sowah, Solomon A. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
+ Nonnenmacher, Tobias. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
+ Schubel, Ruth. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
+ Schubel, Ruth. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
+ Kirsten, Romy. Biobank of the National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany.
+ Johnson, Theron. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
+ von Stackelberg, Oyunbileg. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
+ Ulrich, Cornelia M. Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112-5550, USA.
+ Kaaks, Rudolf. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
+ Kauczor, Hans-Ulrich. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
+ Kuhn, Tilman. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
+ Kuhn, Tilman. Institute for Global Food Security (IGFS), Queen's University Belfast, Belfast BT9 5DL, UK.
+ Kuhn, Tilman. Heidelberg Institute of Global Health (HIGH), Heidelberg University Hospital, 69120 Heidelberg, Germany.
+ Nattenmuller, Johanna. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
+ Nattenmuller, Johanna. Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Biomarkers
+ Humans
+ Kidney/me [Metabolism]
+ Obesity/me [Metabolism]
+ Overweight/co [Complications]
+ *Overweight
+ Weight Loss/ph [Physiology]
+ *Weight Loss
+Keyword Heading
+ body composition
+ diet induced weight loss
+ kidney fat content
+ magnetic resonance imaging
+ obesity
+ overweight
+ renal sinus fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ As the metabolic role of kidney fat remains unclear, we investigated the effects of dietary weight loss on kidney fat content (KFC) and its connection to kidney function and metabolism. Overweight or obese participants (n = 137) of a dietary intervention trial were classified into quartiles of weight loss in a post hoc manner. Kidney sinus (KSF) and cortex fat (KCF) were measured by magnetic resonance imaging at baseline, week 12 and week 50. Weight loss effects on KFC were evaluated by linear mixed models. Repeated measures correlations between KFC, other body fat measures and metabolic biomarkers were obtained. KSF, but not KCF, decreased significantly across weight loss quartiles at week 12 (quartile 4: -21.3%; p = 0.02) and 50 (-22.0%, p = 0.001), which remained significant after adjusting for VAT. There were smaller improvements regarding creatinine (-2.5%, p = 0.02) at week 12, but not week 50. KSF, but not KCF, correlated with visceral (rrm = 0.38) and subcutaneous fat volumes (rrm = 0.31) and liver fat content (rrm = 0.32), as well as diastolic blood pressure and biomarkers of lipid, glucose and liver metabolism. Dietary weight loss is associated with decreases in KSF, but not KCF, which suggests that KSF may be the metabolically relevant ectopic fat depot of the kidney. KSF may be targeted for obesity-related disease prevention.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med22&DO=10.3390%2fnu14071437
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Spurny&issn=2072-6643&title=Nutrients&atitle=Changes+in+Kidney+Fat+upon+Dietary-Induced+Weight+Loss.&volume=14&issue=7&spage=&epage=&date=2022&doi=10.3390%2Fnu14071437&pmid=35406052&sid=OVID:medline
+
+<526>
+Unique Identifier
+ 35057441
+Title
+ Optimal Dietary Intake Composition of Choline and Betaine Is Associated with Minimized Visceral Obesity-Related Hepatic Steatosis in a Case-Control Study.
+Source
+ Nutrients. 14(2), 2022 Jan 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chang TY; Wu CH; Chang CY; Lee FJ; Wang BW; Doong JY; Lin YS; Kuo CS; Huang RS
+Author NameID
+ Wang, Bei-Wen; ORCID: https://orcid.org/0000-0001-7558-4854
+ Doong, Jia-Yau; ORCID: https://orcid.org/0000-0003-0365-3915
+Authors Full Name
+ Chang, Ting-Yu; Wu, Chien-Hsien; Chang, Chi-Yang; Lee, Fu-Jen; Wang, Bei-Wen; Doong, Jia-Yau; Lin, Yu-Shun; Kuo, Chang-Sheng; Huang, Rwei-Fen S.
+Institution
+ Chang, Ting-Yu. Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
+ Wu, Chien-Hsien. Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
+ Wu, Chien-Hsien. Department of Gastroenterology and Hepatology, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 242, Taiwan.
+ Chang, Chi-Yang. Department of Gastroenterology and Hepatology, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan.
+ Lee, Fu-Jen. Department of Gastroenterology and Hepatology, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan.
+ Wang, Bei-Wen. Department of Nutrition, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan.
+ Doong, Jia-Yau. Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
+ Lin, Yu-Shun. Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
+ Kuo, Chang-Sheng. Department of Nutrition, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan.
+ Huang, Rwei-Fen S. Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
+ Huang, Rwei-Fen S. Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
+MeSH Subject Headings
+ Adiposity
+ Aged
+ *Betaine/ad [Administration & Dosage]
+ Biomarkers/bl [Blood]
+ Body Composition
+ Case-Control Studies
+ *Choline/ad [Administration & Dosage]
+ Diet Records
+ Eating
+ Fatty Liver/bl [Blood]
+ Fatty Liver/dg [Diagnostic Imaging]
+ Fatty Liver/et [Etiology]
+ *Fatty Liver/pc [Prevention & Control]
+ Female
+ *Folic Acid/ad [Administration & Dosage]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity, Abdominal/bl [Blood]
+ *Obesity, Abdominal/co [Complications]
+ Obesity, Abdominal/di [Diagnosis]
+ Odds Ratio
+ Taiwan
+ Ultrasonography
+Keyword Heading
+ betaine
+ choline
+ folate
+ hepatic steatosis
+ methyl donor nutrients intake
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Few studies on humans have comprehensively evaluated the intake composition of methyl-donor nutrients (MDNs: choline, betaine, and folate) in relation to visceral obesity (VOB)-related hepatic steatosis (HS), the hallmark of non-alcoholic fatty liver diseases. In this case-control study, we recruited 105 patients with HS and 104 without HS (controls). HS was diagnosed through ultrasound examination. VOB was measured using a whole-body analyzer. MDN intake was assessed using a validated quantitative food frequency questionnaire. After adjustment for multiple HS risk factors, total choline intake was the most significant dietary determinant of HS in patients with VOB (Beta: -0.41, p = 0.01). Low intake of choline (<6.9 mg/kg body weight), betaine (<3.1 mg/kg body weight), and folate (<8.8 mug/kg body weight) predicted increased odds ratios (ORs) of VOB-related HS (choline: OR: 22, 95% confidence interval [CI]: 6.5-80; betaine: OR: 14, 95% CI: 4.4-50; and folate: OR: 19, 95% CI: 5.2-74). Combined high intake of choline and betaine, but not folate, was associated with an 81% reduction in VOB-related HS (OR: 0.19, 95% CI: 0.05-0.69). Our data suggest that the optimal intake of choline and betaine can minimize the risk of VOB-related HS in a threshold-dependent manner.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3SCV180C9W (Betaine). 935E97BOY8 (Folic Acid). N91BDP6H0X (Choline).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fnu14020261
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chang&issn=2072-6643&title=Nutrients&atitle=Optimal+Dietary+Intake+Composition+of+Choline+and+Betaine+Is+Associated+with+Minimized+Visceral+Obesity-Related+Hepatic+Steatosis+in+a+Case-Control+Study.&volume=14&issue=2&spage=&epage=&date=2022&doi=10.3390%2Fnu14020261&pmid=35057441&sid=OVID:medline
+
+<527>
+Unique Identifier
+ 35179193
+Title
+ French-fried potato consumption and energy balance: a randomized controlled trial.
+Source
+ American Journal of Clinical Nutrition. 115(6):1626-1636, 2022 06 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Smith DL; Hanson RL; Dickinson SL; Chen X; Goss AM; Cleek JB; Garvey WT; Allison DB
+Author NameID
+ Smith, Daniel L; ORCID: https://orcid.org/0000-0002-1602-2023
+Authors Full Name
+ Smith, Daniel L; Hanson, Rebecca L; Dickinson, Stephanie L; Chen, Xiwei; Goss, Amy M; Cleek, John B; Garvey, W Timothy; Allison, David B.
+Institution
+ Smith, Daniel L. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Smith, Daniel L. Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Smith, Daniel L. Integrative Center for Aging Resaerch, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Smith, Daniel L. Nathan Shock Center of Excellence in the Biology of Aging, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Hanson, Rebecca L. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Dickinson, Stephanie L. Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.
+ Chen, Xiwei. Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.
+ Goss, Amy M. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Goss, Amy M. Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Cleek, John B. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Garvey, W Timothy. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Garvey, W Timothy. Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Allison, David B. Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Blood Glucose/me [Metabolism]
+ Female
+ Glucose
+ Glycated Hemoglobin
+ Humans
+ Insulin
+ Male
+ Obesity
+ Prunus dulcis/me [Metabolism]
+ *Prunus dulcis
+ *Solanum tuberosum
+ Young Adult
+Keyword Heading
+ French fries
+ adipose
+ carbohydrates
+ glycemia
+ herb/spices
+ nuts
+ potato chips
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Epidemiologic observations suggest increased potato consumption correlates with weight gain, adiposity, and diabetes risk, whereas nut consumption is associated with weight control and metabolic health. Randomized controlled trial (RCT) data indicate humans respond to changes in energy intake in single dietary components and compensate for extra energy consumed.
+
+ OBJECTIVES: We completed an RCT testing whether increased daily potato consumption influences energy balance [specifically, fat mass (FM)] compared with calorie-matched almond consumption.
+
+ METHODS: A 30-d RCT of 180 adults prescribed calorie-matched (300 kcal/d, n = 60 participants/group) than consumed 1 of the following: 1) almonds (almond group), 2) French fries (potato group), or 3) French fries with herb/spices mix (potato + herb/spices group). Baseline and 30-d FM were measured by DXA (primary outcome), with secondary outcomes including body weight and carbohydrate metabolism markers [glycated hemoglobin (HbA1c), fasting blood glucose and insulin, HOMA-IR)]. A subset of 5 participants/group participated in a postprandial meal-based tolerance test.
+
+ RESULTS: A total of 180 participants were randomly assigned [gender: 67.8% female; mean +/- SD age: 30.4 +/- 8.7 y; BMI (in kg/m2): 26.1 +/- 4.2; and weight: 75.6 +/- 15.4 kg], with 12 dropouts and 3 terminations. No significantly different FM changes were observed between almond and potato consumption [combined +/- herb/spices; mean +/- SE almond: 230.87 +/- 114.01 g; potato: 123.73 +/- 86.09 g; P = 0.443], fasting glucose (P = 0.985), insulin (P = 0.082), HOMA-IR (P = 0.080), or HbA1c (P = 0.269). Body weight change was not significantly different in the potato groups combined compared with the almond group (P = 0.116), but was significantly different among the 3 groups (P = 0.014; almond: 0.49 +/- 0.20 kg; potato: -0.24 +/- 0.20 kg; potato + herb/spices: 0.47 +/- 0.21 kg). In meal tests, significantly lower post-prandial glucose and insulin responses to almonds compared with potatoes were observed (P = 0.046, P = 0.006, respectively), with potato + herb/spices having intermediate effects.
+
+ CONCLUSION: There were no significant differences in FM or in glucoregulatory biomarkers after 30 d of potato consumption compared with almonds. Results do not support a causal relation between increased French fried potato consumption and the negative health outcomes studied. This trial was registered at clinicaltrials.gov as NCT03518515. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Insulin). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1093%2fajcn%2fnqac045
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Smith&issn=0002-9165&title=American+Journal+of+Clinical+Nutrition&atitle=French-fried+potato+consumption+and+energy+balance%3A+a+randomized+controlled+trial.&volume=115&issue=6&spage=1626&epage=1636&date=2022&doi=10.1093%2Fajcn%2Fnqac045&pmid=35179193&sid=OVID:medline
+
+<528>
+Unique Identifier
+ 34902008
+Title
+ Adiposity, metabolomic biomarkers, and risk of nonalcoholic fatty liver disease: a case-cohort study.
+Source
+ American Journal of Clinical Nutrition. 115(3):799-810, 2022 03 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pang Y; Kartsonaki C; Lv J; Millwood IY; Fairhurst-Hunter Z; Turnbull I; Bragg F; Hill MR; Yu C; Guo Y; Chen Y; Yang L; Clarke R; Walters RG; Wu M; Chen J; Li L; Chen Z; Holmes MV
+Author NameID
+ Pang, Yuanjie; ORCID: https://orcid.org/0000-0002-4826-8861
+ Yu, Canqing; ORCID: https://orcid.org/0000-0002-0019-0014
+ Clarke, Robert; ORCID: https://orcid.org/0000-0002-9802-8241
+Authors Full Name
+ Pang, Yuanjie; Kartsonaki, Christiana; Lv, Jun; Millwood, Iona Y; Fairhurst-Hunter, Zammy; Turnbull, Iain; Bragg, Fiona; Hill, Michael R; Yu, Canqing; Guo, Yu; Chen, Yiping; Yang, Ling; Clarke, Robert; Walters, Robin G; Wu, Ming; Chen, Junshi; Li, Liming; Chen, Zhengming; Holmes, Michael V.
+Institution
+ Pang, Yuanjie. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
+ Kartsonaki, Christiana. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Kartsonaki, Christiana. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Lv, Jun. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
+ Lv, Jun. Peking University Center for Public Health and Epidemic Preparedness and Response (PKU-PHEPR), Peking University, Beijing, China.
+ Millwood, Iona Y. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Millwood, Iona Y. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Fairhurst-Hunter, Zammy. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Turnbull, Iain. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Bragg, Fiona. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Bragg, Fiona. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Hill, Michael R. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Yu, Canqing. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
+ Yu, Canqing. Peking University Center for Public Health and Epidemic Preparedness and Response (PKU-PHEPR), Peking University, Beijing, China.
+ Guo, Yu. Chinese Academy of Medical Sciences, Beijing, China.
+ Chen, Yiping. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Chen, Yiping. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Yang, Ling. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Yang, Ling. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Clarke, Robert. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Walters, Robin G. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Walters, Robin G. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Wu, Ming. Jiangsu Center for Disease Control and Prevention, Nanjing, China.
+ Chen, Junshi. National Center for Food Safety Risk Assessment, Beijing, China.
+ Li, Liming. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
+ Li, Liming. Peking University Center for Public Health and Epidemic Preparedness and Response (PKU-PHEPR), Peking University, Beijing, China.
+ Chen, Zhengming. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Chen, Zhengming. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Holmes, Michael V. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Holmes, Michael V. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Holmes, Michael V. National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, United Kingdom.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers
+ Cohort Studies
+ Humans
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/me [Metabolism]
+ Prospective Studies
+Keyword Heading
+ Chinese
+ Mendelian randomization
+ adiposity
+ metabolomics
+ nonalcoholic fatty liver disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Globally, the burden of obesity and associated nonalcoholic fatty liver disease (NAFLD) are rising, but little is known about the role that circulating metabolomic biomarkers play in mediating their association.
+
+ OBJECTIVES: We aimed to examine the observational and genetic associations of adiposity with metabolomic biomarkers and the observational associations of metabolomic biomarkers with incident NAFLD.
+
+ METHODS: A case-subcohort study within the prospective China Kadoorie Biobank included 176 NAFLD cases and 180 subcohort individuals and measured 1208 metabolites in stored baseline plasma using a Metabolon assay. In the subcohort the observational and genetic associations of BMI with biomarkers were assessed using linear regression, with adjustment for multiple testing. Cox regression was used to estimate adjusted HRs for NAFLD associated with biomarkers.
+
+ RESULTS: In observational analyses, BMI (kg/m2; mean: 23.9 in the subcohort) was associated with 199 metabolites at a 5% false discovery rate. The effects of genetically elevated BMI with specific metabolites were directionally consistent with the observational associations. Overall, 35 metabolites were associated with NAFLD risk, of which 15 were also associated with BMI, including glutamate (HR per 1-SD higher metabolite: 1.95; 95% CI: 1.48, 2.56), cysteine-glutathione disulfide (0.44; 0.31, 0.62), diaclyglycerol (C32:1) (1.71; 1.24, 2.35), behenoyl dihydrosphingomyelin (C40:0) (1.92; 1.42, 2.59), butyrylcarnitine (C4) (1.91; 1.38, 2.35), 2-hydroxybehenate (1.81; 1.34, 2.45), and 4-cholesten-3-one (1.79; 1.27, 2.54). The discriminatory performance of known risk factors was increased when 28 metabolites were also considered simultaneously in the model (weighted C-statistic: 0.84 to 0.90; P < 0.001).
+
+ CONCLUSIONS: Among relatively lean Chinese adults, a range of metabolomic biomarkers are associated with NAFLD risk and these biomarkers may lie on the pathway between adiposity and NAFLD. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1093%2fajcn%2fnqab392
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pang&issn=0002-9165&title=American+Journal+of+Clinical+Nutrition&atitle=Adiposity%2C+metabolomic+biomarkers%2C+and+risk+of+nonalcoholic+fatty+liver+disease%3A+a+case-cohort+study.&volume=115&issue=3&spage=799&epage=810&date=2022&doi=10.1093%2Fajcn%2Fnqab392&pmid=34902008&sid=OVID:medline
+
+<529>
+Unique Identifier
+ 34814962
+Title
+ Maternal carbohydrate intake during pregnancy is associated with child peripubertal markers of metabolic health but not adiposity.
+Source
+ Public Health Nutrition. 25(9):2541-2553, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mulcahy MC; Tellez-Rojo MM; Cantoral A; Solano-Gonzalez M; Baylin A; Bridges D; Peterson KE; Perng W
+Author NameID
+ Mulcahy, Molly C; ORCID: https://orcid.org/0000-0002-8903-7357
+Authors Full Name
+ Mulcahy, Molly C; Tellez-Rojo, Martha Maria; Cantoral, Alejandra; Solano-Gonzalez, Maritsa; Baylin, Ana; Bridges, Dave; Peterson, Karen E; Perng, Wei.
+Institution
+ Mulcahy, Molly C. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
+ Tellez-Rojo, Martha Maria. Center for Nutrition and Health Research, Instituto de Salud Publica, Cuernavaca, Morelos, Mexico.
+ Cantoral, Alejandra. Department of Health, Universidad Iberoamericana, Prolongacion Paseo de Reforma 880, Lomas de Santa Fe, Ciudad de Mexico, C.P. 01219, Mexico.
+ Solano-Gonzalez, Maritsa. Center for Nutrition and Health Research, Instituto de Salud Publica, Cuernavaca, Morelos, Mexico.
+ Baylin, Ana. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
+ Baylin, Ana. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
+ Bridges, Dave. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
+ Peterson, Karen E. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
+ Peterson, Karen E. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
+ Peterson, Karen E. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
+ Perng, Wei. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
+ Perng, Wei. Department of Epidemiology, Colorado School of Public Health, Anschutz Medical Campus, Aurora, CO, USA.
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ Biomarkers
+ Body Mass Index
+ C-Peptide/me [Metabolism]
+ Carbohydrates
+ Child
+ Female
+ Humans
+ Obesity/me [Metabolism]
+ *Prenatal Exposure Delayed Effects
+ Prospective Studies
+Keyword Heading
+ Adiposity
+ Adolescence
+ Carbohydrate
+ Childhood obesity
+ Metabolic health
+ Nutritional epidemiology
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To examine the associations of trimester-specific maternal prenatal carbohydrate (CHO) intake with offspring adiposity and metabolic health during peripuberty.
+
+ DESIGN: Prospective cohort study in which maternal dietary intake was collected via validated FFQ during each trimester. Offspring adiposity and metabolic biomarkers were evaluated at age 8-14 years. We used multivariable linear regression to examine associations between total energy-adjusted maternal CHO intake and offspring BMI z-score, skinfold thickness and metabolic syndrome risk z-score calculated as the average of waist circumference, fasting glucose, fasting C-peptide, TAG:HDL and systolic blood pressure + diastolic blood pressure/2.
+
+ SETTING: Mexico City, Mexico.
+
+ PARTICIPANTS: 237 mother-child pairs in the Early Life Exposure in Mexico to Environmental Toxicants cohort.
+
+ RESULTS: We found non-linear associations of maternal CHO intake during pregnancy with offspring metabolic health during peripuberty. After adjusting for maternal age, and child age, sex and pubertal status, children whose mothers were in the fourth v. first quartile of total CHO intake during the third trimester had 0.42 (95 % CI -0.01, 0.08) ng/ml lower C-peptide and 0.10 (95 % CI -0.02, 0.22) units lower C-peptide insulin resistance (CP-IR). We found similar magnitude and direction of association with respect to net CHO intake during the first trimester and offspring C-peptide and CP-IR. Maternal CHO intake during pregnancy was not associated with offspring adiposity.
+
+ CONCLUSIONS: In this study of mother-child pairs in Mexico City, children born to women in the highest quartile of CHO intake during pregnancy had lowest C-peptide and CP-IR during peripuberty. Additional research is warranted to replicate and identify mechanisms.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C-Peptide). 0 (Carbohydrates).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1017%2fS1368980021004614
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mulcahy&issn=1368-9800&title=Public+Health+Nutrition&atitle=Maternal+carbohydrate+intake+during+pregnancy+is+associated+with+child+peripubertal+markers+of+metabolic+health+but+not+adiposity.&volume=25&issue=9&spage=2541&epage=2553&date=2022&doi=10.1017%2FS1368980021004614&pmid=34814962&sid=OVID:medline
+
+<530>
+Unique Identifier
+ 35253190
+Title
+ Leptin involvement in the survival of pancreatic adenocarcinoma patients with obesity and diabetes.
+Source
+ European Review for Medical & Pharmacological Sciences. 26(4):1341-1349, 2022 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Man T; Seicean R; Lucaciu L; Leucuta D; Ilies M; Iuga C; Petrusel L; Seicean A
+Authors Full Name
+ Man, T; Seicean, R; Lucaciu, L; Leucuta, D; Ilies, M; Iuga, C; Petrusel, L; Seicean, A.
+Institution
+ Man, T. Department of Gastroenterology, Regional Institute of Gastroenterology and Hepatology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania. rseicean@yahoo.com.
+MeSH Subject Headings
+ *Adenocarcinoma
+ Biomarkers
+ Biomarkers, Tumor
+ Carcinoma, Pancreatic Ductal/me [Metabolism]
+ *Carcinoma, Pancreatic Ductal
+ *Diabetes Mellitus
+ Humans
+ Leptin
+ Obesity/co [Complications]
+ Overweight
+ Pancreatic Neoplasms/me [Metabolism]
+ *Pancreatic Neoplasms
+ Phosphatidylinositol 3-Kinase
+ Phosphatidylinositol 3-Kinases
+ Prognosis
+ Prospective Studies
+ Pancreatic Neoplasms
+Abstract
+ OBJECTIVE: Current molecular characterization of pancreatic ductal adenocarcinoma (PDAC) does not incorporate the host reaction to cancer cells and cannot predict the response to chemo- or immunotherapy. Leptin is an adipokine involved in regulating energy balance with a possible role in the development of obesity-associated cancers, but its relationship with other pathways in pancreatic carcinogenesis has not been established yet. The aim of this prospective study was to assess the involvement of leptin and phosphoinositide 3-kinase (PI3K) in the survival of overweight and/or diabetic patients with PDAC.
+
+ PATIENTS AND METHODS: A total of 112 patients were included, 56 diagnosed with PDAC and 56 age and sex-matched healthy controls, with a maximum follow-up of 24-months. The circulating leptin, interleukin 1-beta, tumor factor necrosis-alpha, and PI3K were measured by enzyme-linked immunosorbent assay (ELISA). A multivariate Cox regression model was used to determine the factors influencing survival.
+
+ RESULTS: The serum levels of leptin [38.5 (31.6-47.0) pg/ml] and other cytokines in PDAC patients were similar to controls, irrespective of the presence of diabetes. No significant correlation between the biomarkers was found. In obese and overweight patients, the leptin level and survival rate were lower than in non-obese patients.
+
+ CONCLUSIONS: The leptin level was not associated with the presence of PDAC, although it was lower in obese and overweight patients who had lower survival. No association with inflammatory biomarkers or PI3K was noted. Furthermore, leptin levels had no independent role in survival, suggesting that the prognostic role of obesity in PDAC is based on a different pathway.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Biomarkers, Tumor). 0 (Leptin). EC 2-7-1-137 (Phosphatidylinositol 3-Kinase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.26355%2feurrev_202202_28127
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Man&issn=1128-3602&title=European+Review+for+Medical+%26+Pharmacological+Sciences&atitle=Leptin+involvement+in+the+survival+of+pancreatic+adenocarcinoma+patients+with+obesity+and+diabetes.&volume=26&issue=4&spage=1341&epage=1349&date=2022&doi=10.26355%2Feurrev_202202_28127&pmid=35253190&sid=OVID:medline
+
+<531>
+Unique Identifier
+ 35383339
+Title
+ Effects of folate supplementation on recurrence and metabolic status of cervical intraepithelial neoplasia grade 2/3 in overweight and obese women: a randomized double-blind placebo-controlled trial.
+Source
+ European Journal of Clinical Nutrition. 76(5):666-670, 2022 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sabihi S; Vahedpoor Z; Saraf-Bank S; Nourian M
+Author NameID
+ Vahedpoor, Zahra; ORCID: http://orcid.org/0000-0001-9309-9078
+ Saraf-Bank, Sahar; ORCID: http://orcid.org/0000-0003-3443-9559
+ Nourian, Mojgan; ORCID: http://orcid.org/0000-0003-2181-6474
+Authors Full Name
+ Sabihi, Sima; Vahedpoor, Zahra; Saraf-Bank, Sahar; Nourian, Mojgan.
+Institution
+ Sabihi, Sima. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Sabihi, Sima. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Vahedpoor, Zahra. Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, IR, Iran.
+ Saraf-Bank, Sahar. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Saraf-Bank, Sahar. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Nourian, Mojgan. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. mojnour42@yahoo.com.
+ Nourian, Mojgan. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. mojnour42@yahoo.com.
+MeSH Subject Headings
+ Biomarkers
+ Blood Glucose/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Dietary Supplements
+ Double-Blind Method
+ Female
+ Folic Acid/tu [Therapeutic Use]
+ Humans
+ Inflammation
+ Insulin
+ *Insulin Resistance
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+ Oxidative Stress
+ Uterine Cervical Neoplasms/pa [Pathology]
+ *Uterine Cervical Neoplasms
+ Uterine Cervical Dysplasia/dt [Drug Therapy]
+ Uterine Cervical Dysplasia/pa [Pathology]
+ *Uterine Cervical Dysplasia
+Abstract
+ BACKGROUND AND OBJECTIVE: Inconsistent evidence showed that folate supplementation may be associated with reduced risk of cancer due to improved metabolic profiles and reduced markers of oxidative stress and inflammation. The aim of this investigation was to quantify the effects of folate supplementation on the recurrence and other metabolic factors of women with cervical intraepithelial neoplasia grade 2/3 (CIN2/3).
+
+ METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed among 60 overweight/obese women with CIN2/3. Definitive CIN2/3 confirmation was done via biopsy, pathological diagnosis, as well as colposcopy. Participants were randomly assigned to the intervention group to take 5 mg/day folate supplements or placebo group (n = 30 in each group) for 12 weeks.
+
+ RESULTS: The results of the current study showed a non-significant decrease in recurrence of CIN2/3 in the folate group in comparison with the placebo group (3.3% vs. 16.7%, P = 0.08). Compared with the placebo, folate supplementation significantly decreased plasma homocysteine (Hcy) levels (P < 0.001), serum insulin values (in the crude model) (P = 0.01), and homeostasis model assessment of insulin resistance (P = 0.01). Also, folate supplementation resulted in a significant improvement in the quantitative insulin sensitivity check index (P = 0.002) and total antioxidant capacity (P = 0.04) and a significant reduction in high-sensitivity C-reactive protein (P = 0.015) in comparison with the placebo group.
+
+ CONCLUSIONS: In conclusion, folate supplementation for 12 weeks among overweight/obese women with CIN2/3 showed a non-significant decrease in its recurrence and had beneficial effects on insulin sensitivity, inflammation, and oxidative stress markers. Copyright © 2021. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 9007-41-4 (C-Reactive Protein). 935E97BOY8 (Folic Acid).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41430-021-01022-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sabihi&issn=0954-3007&title=European+Journal+of+Clinical+Nutrition&atitle=Effects+of+folate+supplementation+on+recurrence+and+metabolic+status+of+cervical+intraepithelial+neoplasia+grade+2%2F3+in+overweight+and+obese+women%3A+a+randomized+double-blind+placebo-controlled+trial.&volume=76&issue=5&spage=666&epage=670&date=2022&doi=10.1038%2Fs41430-021-01022-0&pmid=35383339&sid=OVID:medline
+
+<532>
+Unique Identifier
+ 35381848
+Title
+ No evidence of differential impact of sunflower and rapeseed oil on biomarkers of coronary artery disease or chronic kidney disease in healthy adults with overweight and obesity: result from a randomised control trial.
+Source
+ European Journal of Nutrition. 61(6):3119-3133, 2022 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nicol K; Mansoorian B; Latosinska A; Koutroulaki A; Mullen B; Combet E
+Author NameID
+ Combet, Emilie; ORCID: http://orcid.org/0000-0002-9302-8971
+Authors Full Name
+ Nicol, Katie; Mansoorian, Bahareh; Latosinska, Agnieszka; Koutroulaki, Aimilia; Mullen, Bill; Combet, Emilie.
+Institution
+ Nicol, Katie. Human Nutrition, School of Medicine Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK.
+ Mansoorian, Bahareh. Human Nutrition, School of Medicine Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK.
+ Latosinska, Agnieszka. Mosaiques Diagnostics GmbH, Hannover, Germany.
+ Koutroulaki, Aimilia. Human Nutrition, School of Medicine Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK.
+ Mullen, Bill. Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
+ Combet, Emilie. Human Nutrition, School of Medicine Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK. Emilie.combetaspray@glasgow.ac.uk.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ *Coronary Artery Disease
+ *Helianthus
+ Humans
+ Obesity
+ Overweight
+ Plant Oils/pd [Pharmacology]
+ Proteomics
+ Rapeseed Oil
+ *Renal Insufficiency, Chronic
+ Sunflower Oil
+Keyword Heading
+ Biomarkers
+ Cardiometabolic
+ Cardiovascular
+ Dietary fat
+ Monounsaturated fatty acids
+ Proteomic
+ Rapeseed
+ Seed oils
+ Sunflower
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: The perceived benefits and risks associated with seed oil intake remain controversial, with a limited number of studies investigating the impact of intake on a range of compounds used as cardiometabolic markers. This study aimed to explore the proteomic and cardiometabolic effects of commonly consumed seed oils in the UK, with different fatty acid profiles.
+
+ METHODS: In a parallel randomised control design, healthy adults (n = 84), aged 25-72 with overweight or obesity were randomised to one of three groups: control (habitual diet, CON); 20 mL rapeseed oil per day (RO), or 20 mL sunflower oil per day (SO). Blood, spot urine and anthropometric measures were obtained at 0, 6 and 12 weeks. Proteomic biomarkers analysis was conducted for coronary arterial disease (CAD) and chronic kidney disease (CKD) using capillary electrophoresis coupled to mass spectrometry (CE-MS). Blood lipids, fasting blood glucose, glycative/oxidative stress and inflammatory markers were also analysed.
+
+ RESULTS: No differences in change between time points were observed between groups for CAD or CKD peptide fingerprint scores. No change was detected within groups for CAD or CKD scores. No detectable differences were observed between groups at week 6 or 12 for the secondary outcomes, except median 8-isoprostane, ~ 50% higher in the SO group after 12-weeks compared to RO and CON groups (p = 0.03).
+
+ CONCLUSION: The replacement of habitual fat with either RO or SO for 12 weeks does not lead to an improvement or worsening in cardiovascular health markers in people with overweight or obesity.
+
+ TRIAL REGISTRATION: Trial registration clinicaltrials.gov NCT04867629, retrospectively registered 30/04/2021. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Plant Oils). 0 (Rapeseed Oil). 0 (Sunflower Oil).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs00394-022-02810-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nicol&issn=1436-6207&title=European+Journal+of+Nutrition&atitle=No+evidence+of+differential+impact+of+sunflower+and+rapeseed+oil+on+biomarkers+of+coronary+artery+disease+or+chronic+kidney+disease+in+healthy+adults+with+overweight+and+obesity%3A+result+from+a+randomised+control+trial.&volume=61&issue=6&spage=3119&epage=3133&date=2022&doi=10.1007%2Fs00394-022-02810-5&pmid=35381848&sid=OVID:medline
+
+<533>
+Unique Identifier
+ 35377488
+Title
+ A higher energy-adjusted Dietary Inflammatory Index is positively associated with total and visceral body fat in young male adults.
+Source
+ Journal of Human Nutrition & Dietetics. 35(6):1136-1150, 2022 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Correa CR; da Costa BGG; Silva KS; Shivappa N; Wirth MD; Hebert JR; Nunes EA
+Author NameID
+ Nunes, Everson A; ORCID: https://orcid.org/0000-0001-9994-5677
+Authors Full Name
+ Correa, Cinthia R; da Costa, Bruno G G; Silva, Kelly S; Shivappa, Nitin; Wirth, Michael D; Hebert, James R; Nunes, Everson A.
+Institution
+ Correa, Cinthia R. Health Sciences Center, Nutrition Graduate Program, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ Correa, Cinthia R. Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ da Costa, Bruno G G. Sports Center, Physical Education Graduate Program, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ Silva, Kelly S. Sports Center, Physical Education Graduate Program, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ Shivappa, Nitin. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
+ Shivappa, Nitin. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
+ Wirth, Michael D. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
+ Wirth, Michael D. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
+ Wirth, Michael D. College of Nursing, University of South Carolina, Columbia, South Carolina, USA.
+ Hebert, James R. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
+ Hebert, James R. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
+ Nunes, Everson A. Health Sciences Center, Nutrition Graduate Program, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ Nunes, Everson A. Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+MeSH Subject Headings
+ Adult
+ Male
+ Humans
+ *Intra-Abdominal Fat
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Cross-Sectional Studies
+ Diet
+ Body Mass Index
+ Obesity/co [Complications]
+ Adipose Tissue
+ Cholesterol, HDL
+ Biomarkers
+ Inflammation
+Keyword Heading
+ attitudes and behaviour
+ chronic disease
+ dietary influences
+ disease/therapeutic areas
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The energy-adjusted Dietary Inflammatory Index (E-DII TM) has been associated with a high body mass index and markers of chronic diseases. Also, pro-inflammatory diets with a high E-DII have been positively associated with metabolic disturbances such as glucose intolerance and type II diabetes mellitus. However, it is unclear whether E-DII scores are positively associated with body fat percentage and visceral fat per se. This cross-sectional study aimed to evaluate whether the E-DII is associated with body fat content and metabolic health indicators in lean and obese young men.
+
+ METHODS: The present study was conducted on 59 participants, without comorbidities, not using tobacco, medication and nutritional supplements. Dietary data were obtained by 3-day food records to calculate E-DII scores based on 28 food parameters. Body composition was assessed by dual X-ray absorptiometry (DXA). Blood samples were taken to measure fasting glucose, insulin, triacylglycerols, total cholesterol, and low- and high-density lipoprotein cholesterol. An oral glucose tolerance test also was performed. Associations were determined by mixed-effects linear regression.
+
+ RESULTS: E-DII scores ranged from -3.48 to +3.10. Energy intake was similar across E-DII tertiles. After adjusting for covariates, the highest E-DII tertile was associated with increased body fat, visceral adipose tissue and waist circumference. There was no association between E-DII scores and glycaemic parameters.
+
+ CONCLUSIONS: In young participants, a dietary pattern with a higher E-DII (i.e., pro-inflammatory) score was associated with high body fat and markers of central adiposity assessed by DXA, regardless of body mass. Copyright © 2022 The British Dietetic Association Ltd.
+Registry Number/Name of Substance
+ 0 (Cholesterol, HDL). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1111%2fjhn.13012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Correa&issn=0952-3871&title=Journal+of+Human+Nutrition+%26+Dietetics&atitle=A+higher+energy-adjusted+Dietary+Inflammatory+Index+is+positively+associated+with+total+and+visceral+body+fat+in+young+male+adults.&volume=35&issue=6&spage=1136&epage=1150&date=2022&doi=10.1111%2Fjhn.13012&pmid=35377488&sid=OVID:medline
+
+<534>
+Unique Identifier
+ 35363362
+Title
+ Asprosin, visfatin and subfatin as new biomarkers of obesity and metabolic syndrome.
+Source
+ European Review for Medical & Pharmacological Sciences. 26(6):2124-2133, 2022 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ugur K; Erman F; Turkoglu S; Aydin Y; Aksoy A; Lale A; Karagoz ZK; Ugur I; Akkoc RF; Yalniz M
+Authors Full Name
+ Ugur, K; Erman, F; Turkoglu, S; Aydin, Y; Aksoy, A; Lale, A; Karagoz, Z K; Ugur, I; Akkoc, R F; Yalniz, M.
+Institution
+ Ugur, K. Department of Internal Medicine (Endocrinology and Metabolism Diseases), Faculty of Medicine, Firat University, Elazig, Turkey. yalcinaydinnn@hotmail.com.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Humans
+ *Metabolic Syndrome
+ *Nicotinamide Phosphoribosyltransferase
+ Obesity
+Abstract
+ OBJECTIVE: Metabolic syndrome (MetS) and obesity are important public health problems associated with adipose tissue mass. Asprosin, visfatin, and subfatin are new members of which fate in MetS and obesity has not been fully revealed yet. Thus, this study was to investigate the association between asprosin, visfatin, subfatin, and biochemical values, demographic data, and body composition measurement values in MetS patients with and without obesity.
+
+ PATIENTS AND METHODS: Blood samples were taken from a total of 90 people, including 31 MetS patients with obesity, 29 MetS patients without obesity, and 30 healthy (control). Asprosin, visfatin, and subfatin were studied by the ELISA method.
+
+ RESULTS: There was a negative correlation between asprosin and Body Mass Index (BMI) in the MetS + Obese group. The correlations between asprosin and urea and fasting insulin (FI) levels in the MetS group were positive and statistically significant (p < 0.05). While there was a statistically significant negative correlation (p < 0.05) between visfatin and BMI in the MetS + Obese group, the correlation with waist circumference in the MetS + Obese and MetS groups was statistically significant and negative (p < 0.05). There was a statistically significant negative relationship (p < 0.05) between aspartate aminotransferase value and visfatin. The results between visfatin values and asprosin and subfatin in all groups were significant (p < 0.05).
+
+ CONCLUSIONS: There is a direct relationship between circulating amounts of asprosin, visfatin, and subfatin hormones and age, weight, height, diastolic blood pressure, high-density lipoprotein-cholesterol, aspartate aminotransferase, alanine transaminase, and creatinine. Therefore, asprosin, visfatin, and subfatin hormones are the new biomarkers of metabolic turbulence.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.26355%2feurrev_202203_28360
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ugur&issn=1128-3602&title=European+Review+for+Medical+%26+Pharmacological+Sciences&atitle=Asprosin%2C+visfatin+and+subfatin+as+new+biomarkers+of+obesity+and+metabolic+syndrome.&volume=26&issue=6&spage=2124&epage=2133&date=2022&doi=10.26355%2Feurrev_202203_28360&pmid=35363362&sid=OVID:medline
+
+<535>
+Unique Identifier
+ 35361917
+Title
+ Exosomes as novel biomarkers in metabolic disease and obesity-related cancers.
+Source
+ Nature Reviews Endocrinology. 18(6):327-328, 2022 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jafari N; Llevenes P; Denis GV
+Author NameID
+ Denis, Gerald V; ORCID: http://orcid.org/0000-0001-9886-0401
+Authors Full Name
+ Jafari, Naser; Llevenes, Pablo; Denis, Gerald V.
+Institution
+ Jafari, Naser. Boston University-Boston Medical Center Cancer Center, Boston University School of Medicine, Boston, MA, USA.
+ Llevenes, Pablo. Boston University-Boston Medical Center Cancer Center, Boston University School of Medicine, Boston, MA, USA.
+ Llevenes, Pablo. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
+ Denis, Gerald V. Boston University-Boston Medical Center Cancer Center, Boston University School of Medicine, Boston, MA, USA. gdenis@bu.edu.
+ Denis, Gerald V. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA. gdenis@bu.edu.
+ Denis, Gerald V. Section of Hematology and Medical Oncology, Department of Medicine, Boston University Medical Center, Boston, MA, USA. gdenis@bu.edu.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Exosomes/me [Metabolism]
+ *Exosomes
+ Humans
+ Metabolic Diseases/di [Diagnosis]
+ Metabolic Diseases/me [Metabolism]
+ *Metabolic Diseases
+ Neoplasms/di [Diagnosis]
+ Neoplasms/me [Metabolism]
+ *Neoplasms
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41574-022-00666-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jafari&issn=1759-5029&title=Nature+Reviews+Endocrinology&atitle=Exosomes+as+novel+biomarkers+in+metabolic+disease+and+obesity-related+cancers.&volume=18&issue=6&spage=327&epage=328&date=2022&doi=10.1038%2Fs41574-022-00666-7&pmid=35361917&sid=OVID:medline
+
+<536>
+Unique Identifier
+ 35351696
+Title
+ Empowering consumers to PREVENT diet-related diseases through OMICS sciences (PREVENTOMICS): protocol for a parallel double-blinded randomised intervention trial to investigate biomarker-based nutrition plans for weight loss.
+Source
+ BMJ Open. 12(3):e051285, 2022 03 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aldubayan MA; Pigsborg K; Gormsen SMO; Serra F; Palou M; Mena P; Wetzels M; Calleja A; Caimari A; Del Bas J; Gutierrez B; Magkos F; Hjorth MF
+Author NameID
+ Aldubayan, Mona Adnan; ORCID: https://orcid.org/0000-0002-5398-6673
+ Pigsborg, Kristina; ORCID: https://orcid.org/0000-0003-1987-523X
+Authors Full Name
+ Aldubayan, Mona Adnan; Pigsborg, Kristina; Gormsen, Sophia M O; Serra, Francisca; Palou, Mariona; Mena, Pedro; Wetzels, Mart; Calleja, Alberto; Caimari, Antoni; Del Bas, Josep; Gutierrez, Biotza; Magkos, Faidon; Hjorth, Mads Fiil.
+Institution
+ Aldubayan, Mona Adnan. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark monal@nexs.ku.dk.
+ Aldubayan, Mona Adnan. Department of Clinical Nutrition, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
+ Pigsborg, Kristina. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
+ Gormsen, Sophia M O. R&D, Food and Culinary Department, Simple Feast, Copenhagen, Denmark.
+ Serra, Francisca. Laboratory of Molecular Biology, Nutrition and Biotechnology - NUO group, University of the Balearic Islands, Palma, Spain.
+ Serra, Francisca. Spin-off n.1 of the University of the Balearic Islands, Alimentomica S.L, Palma, Spain.
+ Palou, Mariona. Laboratory of Molecular Biology, Nutrition and Biotechnology - NUO group, University of the Balearic Islands, Palma, Spain.
+ Palou, Mariona. Spin-off n.1 of the University of the Balearic Islands, Alimentomica S.L, Palma, Spain.
+ Mena, Pedro. Human Nutrition Unit, Department of Food and Drug, University of Parma, Parma, Italy.
+ Wetzels, Mart. ONMI, Eindhoven, The Netherlands.
+ Calleja, Alberto. R&D, Food Division, Grupo Carinsa, Barcelona, Spain.
+ Caimari, Antoni. Biotechnology Area, Nutrition and Health Unit, Eurecat Centre Tecnologic de Catalunya, Reus, Spain.
+ Del Bas, Josep. Biotechnology Area, Nutrition and Health Unit, Eurecat Centre Tecnologic de Catalunya, Reus, Spain.
+ Gutierrez, Biotza. Biotechnology Area, Nutrition and Health Unit, Eurecat Centre Tecnologic de Catalunya, Reus, Spain.
+ Magkos, Faidon. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
+ Hjorth, Mads Fiil. Healthy Weight Center, Novo Nordisk Foundation, Hellerup, Denmark.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Diet
+ Female
+ Humans
+ Male
+ Obesity/pc [Prevention & Control]
+ Power, Psychological
+ *Quality of Life
+ Randomized Controlled Trials as Topic
+ *Weight Loss
+Keyword Heading
+ genetics
+ nutrition & dietetics
+ public health
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Personalised nutrition holds immense potential over conventional one-size-fits-all approaches for preventing and treating diet-related diseases, such as obesity. The current study aims to examine whether a personalised nutritional plan produces more favourable health outcomes than a standard approach based on general dietary recommendations in subjects with overweight or obesity and elevated waist circumference.
+
+ METHODS AND ANALYSIS: This project is a 10-week parallel, double-blinded randomised intervention trial. We plan to include 100 adults aged 18-65 years interested in losing weight, with body mass index >=27 but<40 kg/m2 and elevated waist circumference (males >94 cm; females >80 cm). Participants will be categorised into one of five predefined 'clusters' based on their individual metabolic biomarker profile and genetic background, and will be randomised in a 1:1 ratio to one of two groups: (1) personalised plan group that will receive cluster-specific meals every day for 6 days a week, in conjunction with a personalised behavioural change programme via electronic push notifications; or (2) control group that will receive meals following the general dietary recommendations in conjunction with generic health behaviour prompts. The primary outcome is the difference between groups (personalised vs control) in the change in fat mass from baseline. Secondary outcomes include changes in weight and body composition, fasting blood glucose and insulin, lipid profile, adipokines, inflammatory biomarkers, and blood pressure. Other outcomes involve measures of physical activity and sleep patterns, health-related quality of life, dietary intake, eating behaviour, and biomarkers of food intake. The effect of the intervention on the primary outcome will be analysed by means of linear mixed models.
+
+ ETHICS AND DISSEMINATION: The protocol has been approved by the Ethics Committee of the Capital Region, Copenhagen, Denmark. Study findings will be disseminated through peer-reviewed publications, conference presentations and media outlets.
+
+ TRIAL REGISTRATION NUMBER: NCT04590989. Copyright © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial Protocol. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1136%2fbmjopen-2021-051285
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aldubayan&issn=2044-6055&title=BMJ+Open&atitle=Empowering+consumers+to+PREVENT+diet-related+diseases+through+OMICS+sciences+%28PREVENTOMICS%29%3A+protocol+for+a+parallel+double-blinded+randomised+intervention+trial+to+investigate+biomarker-based+nutrition+plans+for+weight+loss.&volume=12&issue=3&spage=e051285&epage=&date=2022&doi=10.1136%2Fbmjopen-2021-051285&pmid=35351696&sid=OVID:medline
+
+<537>
+Unique Identifier
+ 35341464
+Title
+ The association of interleukin-6, interleukin-27, and body roundness index with gestational diabetes mellitus.
+Source
+ Journal of Obstetrics & Gynaecology. 42(6):1728-1733, 2022 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tutar D; Cintesun FNI; Gunenc O; Cetinkaya CD
+Author NameID
+ Tutar, Dilek; ORCID: https://orcid.org/0000-0002-8723-3047
+ Cintesun, Feyza Nur Incesu; ORCID: https://orcid.org/0000-0003-2131-962X
+ Gunenc, Oguzhan; ORCID: https://orcid.org/0000-0003-4373-5245
+ Cetinkaya, Cigdem Damla; ORCID: https://orcid.org/0000-0002-6052-4645
+Authors Full Name
+ Tutar, Dilek; Cintesun, Feyza Nur Incesu; Gunenc, Oguzhan; Cetinkaya, Cigdem Damla.
+Institution
+ Tutar, Dilek. Department of Obstetrics and Gynecology, University of Health Sciences Konya Training and Research Hospital, Konya, Turkey.
+ Cintesun, Feyza Nur Incesu. Department of Obstetrics and Gynecology, University of Health Sciences Konya Training and Research Hospital, Konya, Turkey.
+ Gunenc, Oguzhan. Department of Obstetrics and Gynecology, University of Health Sciences Konya Training and Research Hospital, Konya, Turkey.
+ Cetinkaya, Cigdem Damla. Department of Biochemistry, University of Health Sciences Konya Training and Research Hospital, Konya, Turkey.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ *Cardiovascular Diseases
+ Diabetes, Gestational/di [Diagnosis]
+ *Diabetes, Gestational
+ Female
+ Glycated Hemoglobin
+ Humans
+ Infant, Newborn
+ *Interleukin-27
+ *Interleukin-6/bl [Blood]
+ *Interleukins/bl [Blood]
+ Obesity/co [Complications]
+ Pregnancy
+ Risk Factors
+Keyword Heading
+ Body mass index
+ body roundness index
+ gestational diabetes mellitus
+ interleukin-27
+ interleukin-6
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We aimed to investigate the relationship between GDM and IL-27, IL-6, and body roundness index (BRI), a new anthropometric measurement more sensitive than BMI in identifying obesity and predicting cardiometabolic outcomes. We enrolled 80 patients, 40 pregnant women with GDM and 40 healthy pregnant women at midgestation. The women's anthropometric measurements were recorded and serum markers and IL-6, IL-27 were analysed. At the time of delivery maternal, neonatal results were recorded. Women with GDM had significantly higher pregestational, midgestational and prepartum BMI and midgestational BRI; HOMA-IR; HbA1c; and IL-6 values and lower HDL values (p < .05). There was no statistically significant difference in IL-27 values between the groups (p = .939). In multivariate logistic regression analysis, HbA1c, IL-6 (>4.886 pg/mL), and BRI (>6.708) were found as independent risk factors associated with GDM (p < .05). Mean BRI was significantly associated with obesity (p < .001) and BRI higher than 6.708 was found to have 67.5% sensitivity and 80% specificity in the prediction of GDM. Women with GDM had elevated IL-6 levels, but no relationship was detected between IL-27 and GDM. BRI is a new anthropometric index that strongly correlated with BMI and seems to be a reliable alternative to BMI for the evaluation of obesity in GDM patients.IMPACT STATEMENTWhat's already known on this subject? Gestational diabetes mellitus (GDM) is the most common systemic disease in pregnancy. The risk of GDM was 3 times higher in obese pregnant women compared to normal weighted patients. IL-6 is an adipose-derived cytokine that was found to be associated with GDM. The body roundness index (BRI) is a new sensitive anthropometric index for detecting obesity and its secondary cardiometabolic results. What do the results of this study add? Our results showed that BRI was strongly correlated with obesity in GDM patients. HbA1c, IL-6 and BRI were found as independent risk factors associated with GDM. IL 27, a cytokine associated with inflammatory diseases, was not associated with GDM. What are the implications of these findings for clinical practice and/or further research? BRI could be a reliable alternative to BMI for the evaluation of obesity in pregnant women and predicting cardiometabolic outcomes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (IL6 protein, human). 0 (Interleukin-27). 0 (Interleukin-6). 0 (Interleukins). 0 (MYDGF protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f01443615.2022.2036956
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tutar&issn=0144-3615&title=Journal+of+Obstetrics+%26+Gynaecology&atitle=The+association+of+interleukin-6%2C+interleukin-27%2C+and+body+roundness+index+with+gestational+diabetes+mellitus.&volume=42&issue=6&spage=1728&epage=1733&date=2022&doi=10.1080%2F01443615.2022.2036956&pmid=35341464&sid=OVID:medline
+
+<538>
+Unique Identifier
+ 35339664
+Title
+ The triglycerides and glucose (TyG) index: A new marker associated with nonalcoholic steatohepatitis (NASH) in obese patients.
+Source
+ Diabetes & Metabolism. 48(4):101345, 2022 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Riviere B; Jaussent A; Macioce V; Faure S; Builles N; Lefebvre P; Geraud P; Picot MC; Rebuffat S; Renard E; Paradis V; Servais MD; de Preville N; Nocca D; Lajoix AD; Pageaux GP; Galtier F
+Corporate Author
+ COMET study group
+Authors Full Name
+ Riviere, Benjamin; Jaussent, Audrey; Macioce, Valerie; Faure, Stephanie; Builles, Nicolas; Lefebvre, Patrick; Geraud, Philippe; Picot, Marie-Christine; Rebuffat, Sandra; Renard, Eric; Paradis, Valerie; Servais, Marie-Dominique; de Preville, Nathalie; Nocca, David; Lajoix, Anne-Dominique; Pageaux, Georges-Philippe; Galtier, Florence.
+Institution
+ Riviere, Benjamin. Pathology Department, CHU Montpellier, Univ Montpellier, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
+ Jaussent, Audrey. Clinical research and epidemiology unit, CHU Montpellier, Univ Montpellier, 39 avenue Charles Flahault, 34295 Montpellier, France.
+ Macioce, Valerie. Clinical research and epidemiology unit, CHU Montpellier, Univ Montpellier, 39 avenue Charles Flahault, 34295 Montpellier, France.
+ Faure, Stephanie. Hepato-gastroenterology department, CHU Montpellier, Univ Montpellier, 34295 Montpellier, France.
+ Builles, Nicolas. Biological Resources Center; Tissue Bank, CHU Montpellier, Univ Montpellier, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
+ Lefebvre, Patrick. Endocrinology Department, CHU Montpellier, Univ Montpellier, 371 Av du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France.
+ Geraud, Philippe. Clinical Investigation Center 1411, INSERM, CHU Montpellier, Univ Montpellier, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
+ Picot, Marie-Christine. Clinical research and epidemiology unit, CHU Montpellier, Univ Montpellier, 39 avenue Charles Flahault, 34295 Montpellier, France; Clinical Investigation Center 1411, INSERM, CHU Montpellier, Univ Montpellier, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
+ Rebuffat, Sandra. Biocommunication in Cardio-Metabolism (BC2M), University of Montpellier, 15 avenue Charles Flahault, 34093 Montpellier cedex 5, France.
+ Renard, Eric. Endocrinology Department, CHU Montpellier, Univ Montpellier, 371 Av du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France; Clinical Investigation Center 1411, INSERM, CHU Montpellier, Univ Montpellier, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
+ Paradis, Valerie. DHU UNITY, Pathology Department, Hopital Beaujon, AP-HP, Clichy, France.
+ Servais, Marie-Dominique. Servier, 50 rue Carnot, 92284 Suresnes Cedex, France.
+ de Preville, Nathalie. Servier, 50 rue Carnot, 92284 Suresnes Cedex, France.
+ Nocca, David. Department of Digestive Surgery, CHU Montpellier, Univ Montpellier, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
+ Lajoix, Anne-Dominique. Biocommunication in Cardio-Metabolism (BC2M), University of Montpellier, 15 avenue Charles Flahault, 34093 Montpellier cedex 5, France.
+ Pageaux, Georges-Philippe. Hepato-gastroenterology department, CHU Montpellier, Univ Montpellier, 34295 Montpellier, France.
+ Galtier, Florence. Endocrinology Department, CHU Montpellier, Univ Montpellier, 371 Av du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France; Clinical Investigation Center 1411, INSERM, CHU Montpellier, Univ Montpellier, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France. Electronic address: f-galtier@chu-montpellier.fr.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers
+ Biopsy
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ *Diabetes Mellitus, Type 2
+ Female
+ Fibrosis
+ Glucose
+ Humans
+ Liver/pa [Pathology]
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/pa [Pathology]
+ Triglycerides
+ Young Adult
+Keyword Heading
+ Fibrosis
+ Morbid obesity
+ NAFLD
+ NASH
+ TyG
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Diagnosis of nonalcoholic steatohepatitis (NASH) relies on liver biopsy. Noninvasive tools would be useful to target patients to refer for a biopsy. We aimed to determine the diagnostic value of the triglycerides and glucose (TyG) index, an insulin-resistance indicator, to predict NASH.
+
+ METHODS: Our study included grade II-III obese patients aged 18-65 years undergoing bariatric surgery and included in the COMET (COllection of MEtabolic Tissues) biobank (NCT02861781). Liver biopsies performed during bariatric surgery were collected from the biobank along with blood derivatives. Biopsies were analysed according to the steatosis, activity and fibrosis (SAF) scoring system to diagnose NASH, nonalcoholic fatty liver disease (NAFLD), and fibrosis. Logistic regression models were performed to identify factors predicting NASH, NAFLD, and fibrosis.
+
+ RESULTS: Of 238 analysed subjects (mean age 43+/-12 years, 33.6% men), 29% had type 2 diabetes. Steatosis was present in 67.2%, while NASH and advanced fibrosis (stage F3) were diagnosed in 18.1% and 2.9% respectively. TyG index was independently associated with NASH (odds ratio (OR): 4.7 [95% confidence interval: 2.3;9.5] P < 0.0001), NAFLD (OR: 2.0 [1.1;3.7] P = 0.03) and stages 2-3 fibrosis (OR: 4.0 [1.5;10.8] P = 0.007). NASH was also predicted by gamma-glutamyl transferase (GGT) with an area under the ROC curve: 0.79 [0.71;0.87 P = 0.04] for GGT and TyG index combined.
+
+ CONCLUSION: In our cohort of severely obese patients, TyG index, when associated with GGT level, exhibited high diagnostic performance to predict NASH. Although validation in larger populations is needed, this result may be of considerable clinical value to predict need for liver biopsy. Copyright © 2022 Elsevier Masson SAS. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Clinical Study. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.diabet.2022.101345
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Riviere&issn=1262-3636&title=Diabetes+%26+Metabolism&atitle=The+triglycerides+and+glucose+%28TyG%29+index%3A+A+new+marker+associated+with+nonalcoholic+steatohepatitis+%28NASH%29+in+obese+patients.&volume=48&issue=4&spage=101345&epage=&date=2022&doi=10.1016%2Fj.diabet.2022.101345&pmid=35339664&sid=OVID:medline
+
+<539>
+Unique Identifier
+ 35333917
+Title
+ A Simple Test to Identify the Risk of NASH and Cirrhosis in People With Obesity or Diabetes: The Time to Screen Is Now.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 107(7):e3076-e3077, 2022 06 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cusi K
+Author NameID
+ Cusi, Kenneth; ORCID: https://orcid.org/0000-0002-8629-418X
+Authors Full Name
+ Cusi, Kenneth.
+Institution
+ Cusi, Kenneth. Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, USA.
+Comments
+ Comment on (CON)
+ Erratum in (EIN)
+MeSH Subject Headings
+ Biomarkers
+ *Diabetes Mellitus
+ Humans
+ Liver Cirrhosis/co [Complications]
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+Keyword Heading
+ CK-18
+ FIB-4
+ NASH
+ NFS
+ PRO-C3
+ hepatic steatosis
+ insulin resistance
+ nonalcoholic fatty liver disease
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1210%2fclinem%2fdgac186
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cusi&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=A+Simple+Test+to+Identify+the+Risk+of+NASH+and+Cirrhosis+in+People+With+Obesity+or+Diabetes%3A+The+Time+to+Screen+Is+Now.&volume=107&issue=7&spage=e3076&epage=e3077&date=2022&doi=10.1210%2Fclinem%2Fdgac186&pmid=35333917&sid=OVID:medline
+
+<540>
+Unique Identifier
+ 35329213
+Title
+ Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 19(6), 2022 03 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jarecki J; Malecka-Masalska T; Kosior-Jarecka E; Widuchowski W; Krasowski P; Gutbier M; Dobrzynski M; Blicharski T
+Author NameID
+ Jarecki, Jaromir; ORCID: https://orcid.org/0000-0002-6866-3850
+ Malecka-Masalska, Teresa; ORCID: https://orcid.org/0000-0003-3384-0324
+ Kosior-Jarecka, Ewa; ORCID: https://orcid.org/0000-0002-5251-7998
+ Widuchowski, Wojciech; ORCID: https://orcid.org/0000-0002-3684-7823
+ Krasowski, Piotr; ORCID: https://orcid.org/0000-0001-9979-0011
+ Dobrzynski, Maciej; ORCID: https://orcid.org/0000-0003-2368-1534
+ Blicharski, Tomasz; ORCID: https://orcid.org/0000-0001-9747-8817
+Authors Full Name
+ Jarecki, Jaromir; Malecka-Masalska, Teresa; Kosior-Jarecka, Ewa; Widuchowski, Wojciech; Krasowski, Piotr; Gutbier, Martina; Dobrzynski, Maciej; Blicharski, Tomasz.
+Institution
+ Jarecki, Jaromir. Department of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland.
+ Jarecki, Jaromir. Department of Orthopaedics and Traumatology, Regional Hospital in Chelm, 22-100 Chelm, Poland.
+ Malecka-Masalska, Teresa. Physiology Department, Medical University of Lublin, 20-059 Lublin, Poland.
+ Kosior-Jarecka, Ewa. Department Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, 20-079 Lublin, Poland.
+ Widuchowski, Wojciech. Departament of Physiotherapy, The College of Physiotherapy, 50-038 Wroclaw, Poland.
+ Krasowski, Piotr. Department of Orthopaedics and Traumatology, Regional Hospital in Chelm, 22-100 Chelm, Poland.
+ Gutbier, Martina. Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.
+ Dobrzynski, Maciej. Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.
+ Blicharski, Tomasz. Department of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland.
+MeSH Subject Headings
+ Biomarkers
+ Female
+ Humans
+ Matrix Metalloproteinase 13
+ Matrix Metalloproteinase 3
+ *Matrix Metalloproteinase 9
+ Obesity
+ *Osteoarthritis, Knee
+ Osteocalcin
+ Synovial Fluid/ch [Chemistry]
+Keyword Heading
+ female
+ knee
+ matrix metalloproteinases
+ obesity
+ osteoarthritis
+ osteocalcin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The aim of the study was to evaluate the levels of selected MMPs (matrix metalloproteinases) and osteocalcin in the serum and synovial fluid of obese women with osteoarthritis and their correlations with clinical status. The studied group consisted of 39 overweight females undergoing primary total knee arthroplasty due to osteoarthritis (OA). The staging of knee OA was evaluated according to the Ahlback and Kellgren-Lawrence scores. Synovial fluid and peripheral blood samples were obtained. The levels of selected MMPs and osteocalcin were assessed using commercial ELISA kits. The mean value of MMP3 was significantly higher in patients with more advanced disease in both serum (p = 0.0067) and synovial fluid (p = 0.0328). The pro-MMP13 level tended to be higher in synovial fluid in the case of more advanced stages (p = 0.0882), with no tendency regarding the serum level (p = 0.9595). The synovial level of pro-MMP1 was significantly correlated with the synovial concentration of MMP9 and MMP3. The synovial level of MMP9 also showed a significant correlation with the synovial level of MMP3 and pro-MMP13. Furthermore, it was found that the serum level of MMP3 was significantly correlated with the synovial pro-MMP13 level. A correlation between the osteocalcin level in serum and its synovial level was determined. The serum MMP9 level showed a significant correlation with BMI, whereas the synovial MMP9 level was notably correlated with age. Our results showed that the levels of MMP3, MMP9, and pro-MMP13 increased in more advanced radiological stages of OA, indicating the underlying inflammatory process of OA.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 104982-03-8 (Osteocalcin). EC 3-4-24 (MMP13 protein, human). EC 3-4-24 (Matrix Metalloproteinase 13). EC 3-4-24-17 (MMP3 protein, human). EC 3-4-24-17 (Matrix Metalloproteinase 3). EC 3-4-24-35 (MMP9 protein, human). EC 3-4-24-35 (Matrix Metalloproteinase 9).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fijerph19063530
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jarecki&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Concentration+of+Selected+Metalloproteinases+and+Osteocalcin+in+the+Serum+and+Synovial+Fluid+of+Obese+Women+with+Advanced+Knee+Osteoarthritis.&volume=19&issue=6&spage=&epage=&date=2022&doi=10.3390%2Fijerph19063530&pmid=35329213&sid=OVID:medline
+
+<541>
+Unique Identifier
+ 35328382
+Title
+ The Combination of Intestinal Alkaline Phosphatase Treatment with Moderate Physical Activity Alleviates the Severity of Experimental Colitis in Obese Mice via Modulation of Gut Microbiota, Attenuation of Proinflammatory Cytokines, Oxidative Stress Biomarkers and DNA Oxidative Damage in Colonic Mucosa.
+Source
+ International Journal of Molecular Sciences. 23(6), 2022 Mar 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wojcik-Grzybek D; Hubalewska-Mazgaj M; Surmiak M; Sliwowski Z; Dobrut A; Mlodzinska A; Wojcik A; Kwiecien S; Magierowski M; Mazur-Bialy A; Bilski J; Brzozowski T
+Author NameID
+ Wojcik-Grzybek, Dagmara; ORCID: https://orcid.org/0000-0003-3098-9617
+ Dobrut, Anna; ORCID: https://orcid.org/0000-0001-9937-5301
+ Mlodzinska, Agata; ORCID: https://orcid.org/0000-0002-4062-6855
+ Kwiecien, Slawomir; ORCID: https://orcid.org/0000-0002-4806-8042
+ Magierowski, Marcin; ORCID: https://orcid.org/0000-0003-0175-5600
+ Mazur-Bialy, Agnieszka; ORCID: https://orcid.org/0000-0003-1056-8276
+ Bilski, Jan; ORCID: https://orcid.org/0000-0002-2699-3798
+ Brzozowski, Tomasz; ORCID: https://orcid.org/0000-0002-5805-0065
+Authors Full Name
+ Wojcik-Grzybek, Dagmara; Hubalewska-Mazgaj, Magdalena; Surmiak, Marcin; Sliwowski, Zbigniew; Dobrut, Anna; Mlodzinska, Agata; Wojcik, Adrianna; Kwiecien, Slawomir; Magierowski, Marcin; Mazur-Bialy, Agnieszka; Bilski, Jan; Brzozowski, Tomasz.
+Institution
+ Wojcik-Grzybek, Dagmara. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+ Hubalewska-Mazgaj, Magdalena. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+ Surmiak, Marcin. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+ Sliwowski, Zbigniew. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+ Dobrut, Anna. Department of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+ Mlodzinska, Agata. Bioidea Company, 02-991 Warsaw, Poland.
+ Wojcik, Adrianna. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+ Kwiecien, Slawomir. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+ Magierowski, Marcin. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+ Mazur-Bialy, Agnieszka. Department of Biomechanics and Kinesiology, Chair of Biomedical Sciences, Faculty of Health Sciences, Jagiellonian University Medical College, 31-008 Cracow, Poland.
+ Bilski, Jan. Department of Biomechanics and Kinesiology, Chair of Biomedical Sciences, Faculty of Health Sciences, Jagiellonian University Medical College, 31-008 Cracow, Poland.
+ Brzozowski, Tomasz. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
+MeSH Subject Headings
+ Alkaline Phosphatase
+ Animals
+ Biomarkers/me [Metabolism]
+ Colitis/ci [Chemically Induced]
+ *Colitis
+ Cytokines/me [Metabolism]
+ Disease Models, Animal
+ *Gastrointestinal Microbiome
+ Intestinal Mucosa/me [Metabolism]
+ Mice
+ Mice, Obese
+ Obesity
+ Oxidative Stress
+Keyword Heading
+ diet-induced obesity
+ experimental colitis
+ inflammation
+ intestinal alkaline phosphatase
+ oxidative stress
+ voluntary exercise
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Inflammatory bowel diseases (IBD) are commonly considered as Crohn's disease and ulcerative colitis, but the possibility that the alterations in gut microbiota and oxidative stress may affect the course of experimental colitis in obese physically exercising mice treated with the intestinal alkaline phosphatase (IAP) has been little elucidated. Mice fed a high-fat-diet (HFD) or normal diet (ND) for 14 weeks were randomly assigned to exercise on spinning wheels (SW) for 7 weeks and treated with IAP followed by intrarectal administration of TNBS. The disease activity index (DAI), grip muscle strength test, oxidative stress biomarkers (MDA, SOD, GSH), DNA damage (8-OHdG), the plasma levels of cytokines IL-2, IL-6, IL-10, IL-12p70, IL-17a, TNF-alpha, MCP-1 and leptin were assessed, and the stool composition of the intestinal microbiota was determined by next generation sequencing (NGS). The TNBS-induced colitis was worsened in obese sedentary mice as manifested by severe colonic damage, an increase in DAI, oxidative stress biomarkers, DNA damage and decreased muscle strength. The longer running distance and weight loss was observed in mice given IAP or subjected to IAP + SW compared to sedentary ones. Less heterogeneous microbial composition was noticed in sedentary obese colitis mice and this effect disappeared in IAP + SW mice. Absence of Alistipes, lower proportion of Turicibacter, Proteobacteria and Faecalibacterium, an increase in Firmicutes and Clostridium, a decrease in oxidative stress biomarkers, 8-OHdG content and proinflammatory cytokines were observed in IAP + SW mice. IAP supplementation in combination with moderate physical activity attenuates the severity of murine colitis complicated by obesity through a mechanism involving the downregulation of the intestinal cytokine/chemokine network and oxidative stress, the modulation of the gut microbiota and an improvement of muscle strength.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). EC 3-1-3-1 (Alkaline Phosphatase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fijms23062964
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wojcik-Grzybek&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=The+Combination+of+Intestinal+Alkaline+Phosphatase+Treatment+with+Moderate+Physical+Activity+Alleviates+the+Severity+of+Experimental+Colitis+in+Obese+Mice+via+Modulation+of+Gut+Microbiota%2C+Attenuation+of+Proinflammatory+Cytokines%2C+Oxidative+Stress+Biomarkers+and+DNA+Oxidative+Damage+in+Colonic+Mucosa.&volume=23&issue=6&spage=2964&epage=&date=2022&doi=10.3390%2Fijms23062964&pmid=35328382&sid=OVID:medline
+
+<542>
+Unique Identifier
+ 35319116
+Title
+ Anti-Mullerian hormone concentration is associated with central adiposity and reproductive hormones in expectant fathers.
+Source
+ Clinical Endocrinology. 97(5):634-642, 2022 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hadlow NC; Brown SJ; Lim EM; Prentice D; Pettigrew S; Cronin SL; Prescott SL; Silva D; Yeap BB
+Author NameID
+ Yeap, Bu B; ORCID: https://orcid.org/0000-0002-7612-5892
+Authors Full Name
+ Hadlow, Narelle C; Brown, Suzanne J; Lim, Ee Mun; Prentice, David; Pettigrew, Simone; Cronin, Sophie L; Prescott, Susan L; Silva, Desiree; Yeap, Bu B.
+Institution
+ Hadlow, Narelle C. Medical School, University of Western Australia, Perth, Western Australia, Australia.
+ Hadlow, Narelle C. Biochemistry Department, Sonic Healthcare, Clinipath Pathology, Perth, Western Australia, Australia.
+ Brown, Suzanne J. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
+ Lim, Ee Mun. Medical School, University of Western Australia, Perth, Western Australia, Australia.
+ Lim, Ee Mun. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
+ Lim, Ee Mun. Biochemistry Department, PathWest Laboratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
+ Prentice, David. Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.
+ Pettigrew, Simone. George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
+ Cronin, Sophie L. Medical School, University of Western Australia, Perth, Western Australia, Australia.
+ Prescott, Susan L. Medical School, University of Western Australia, Perth, Western Australia, Australia.
+ Prescott, Susan L. The ORIGINS Project, Telethon Kids Institute, Perth, Western Australia, Australia.
+ Prescott, Susan L. Department of Immunology, Perth Children's Hospital, Perth, Western Australia, Australia.
+ Silva, Desiree. Medical School, University of Western Australia, Perth, Western Australia, Australia.
+ Silva, Desiree. The ORIGINS Project, Telethon Kids Institute, Perth, Western Australia, Australia.
+ Silva, Desiree. Department of Paediatrics, Joondalup Health Campus, Perth, Western Australia, Australia.
+ Silva, Desiree. School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
+ Yeap, Bu B. Medical School, University of Western Australia, Perth, Western Australia, Australia.
+ Yeap, Bu B. Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ *Anti-Mullerian Hormone
+ Biomarkers
+ Fathers
+ Female
+ Follicle Stimulating Hormone
+ Humans
+ Luteinizing Hormone
+ Male
+ Obesity
+ Obesity, Abdominal
+ Pregnancy
+ Prospective Studies
+ *Sex Hormone-Binding Globulin
+ Testosterone
+ Young Adult
+Keyword Heading
+ AMH
+ BMI
+ FSH
+ ORIGINS Project
+ men
+ testosterone
+ waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The role of the anti-Mullerian hormone (AMH) as an indicator of physical and reproductive health in men is unclear. We assessed the relationships between AMH and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and metabolic parameters, in a cohort of expectant fathers.
+
+ DESIGN: ORIGINS Project prospective cohort study.
+
+ SETTING: Community-dwelling men.
+
+ PARTICIPANTS: Partners of pregnant women attending antenatal appointments.
+
+ MAIN OUTCOME MEASURES: Serum AMH, FSH, LH, testosterone, and metabolic parameters.
+
+ RESULTS: In 485 expectant fathers, median age 33 years, median AMH was 40 pmol/L (quartiles 29, 56). AMH was inversely correlated with FSH, age, and body mass index (BMI) (correlation coefficients: -.32, -.24, and -.17 respectively). The age association was nonlinear, with peak AMH between 20 and 30 years, a decline thereafter, and somewhat steady levels after 45 years. The inverse association of AMH with FSH was log-linear and independent of age and BMI (beta: -.07, SE: 0.01, p < .001). AMH was inversely correlated with waist circumference and directly associated with sex hormone-binding globulin. Testosterone was moderately correlated with AMH (correlation coefficient: .09, beta: .011, SE: 0.004, p = .014): this association was mediated by an inverse relationship with BMI (mediated proportion 0.49, p < .001).
+
+ CONCLUSIONS: In reproductively active men, lower AMH is a biomarker for advancing age, and for poorer metabolic and reproductive health. The inverse association between AMH and FSH is independent of age and BMI, whereas the association of AMH and testosterone is mediated via BMI. The utility of AMH to predict reproductive and cardiometabolic outcomes in men warrants further investigation. Copyright © 2022 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Sex Hormone-Binding Globulin). 3XMK78S47O (Testosterone). 80497-65-0 (Anti-Mullerian Hormone). 9002-67-9 (Luteinizing Hormone). 9002-68-0 (Follicle Stimulating Hormone).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1111%2fcen.14725
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hadlow&issn=0300-0664&title=Clinical+Endocrinology&atitle=Anti-Mullerian+hormone+concentration+is+associated+with+central+adiposity+and+reproductive+hormones+in+expectant+fathers.&volume=97&issue=5&spage=634&epage=642&date=2022&doi=10.1111%2Fcen.14725&pmid=35319116&sid=OVID:medline
+
+<543>
+Unique Identifier
+ 35306660
+Title
+ Improvement of sleep by resistant dextrin prebiotic in type 2 diabetic women coincides with attenuation of metabolic endotoxemia: involvement of gut-brain axis.
+Source
+ Journal of the Science of Food & Agriculture. 102(12):5229-5237, 2022 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Saleh-Ghadimi S; Dehghan P; Sarmadi B; Maleki P
+Author NameID
+ Dehghan, Parvin; ORCID: https://orcid.org/0000-0001-8929-3302
+Authors Full Name
+ Saleh-Ghadimi, Sevda; Dehghan, Parvin; Sarmadi, Bahareh; Maleki, Parham.
+Institution
+ Saleh-Ghadimi, Sevda. Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Dehghan, Parvin. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Sarmadi, Bahareh. Department of Nutrition Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
+ Maleki, Parham. Student Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+MeSH Subject Headings
+ Biomarkers
+ Brain-Gut Axis
+ Dextrins
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 2
+ Endotoxemia/dt [Drug Therapy]
+ *Endotoxemia
+ Endotoxins
+ Female
+ Glycated Hemoglobin
+ Humans
+ Hydrocortisone
+ Hypothalamo-Hypophyseal System
+ Interleukin-10
+ Interleukin-18
+ Interleukin-6
+ Obesity/dt [Drug Therapy]
+ Pituitary-Adrenal System
+ Prebiotics
+ Quality of Life
+ Sleep
+ Tumor Necrosis Factor-alpha
+Keyword Heading
+ HPA axis
+ inflammation
+ metabolic endotoxemia
+ prebiotic
+ sleep
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Resistant dextrin, as a prebiotic and functional food, may possess favorable effects in type 2 diabetes. This study was conducted to assess whether supplementation with resistant dextrin can improve sleep and quality of life in obese type 2 diabetic women.
+
+ RESULTS: In this randomized controlled trial, female obese type 2 diabetic patients (n = 76) were randomly assigned into intervention group (n = 38) and placebo group (n = 38), and received 10 g day-1 of resistant dextrin or maltodextrin for a period of 8 weeks, respectively. Sleep quality and quality of life (QOL) were assessed by Pittsburgh Sleep Quality Index (PSQI) and SF-36 health survey, respectively. Fasting blood samples were driven to measure serum bacterial endotoxin, fasting blood sugar, glycosylated hemoglobin (HbA1c), pro-inflammatory/anti-inflammatory biomarkers (IL-18, IL-6, IL-10, TNF-alpha), and biomarkers of hypothalamic-pituitary-adrenal (HPA) axis function [tryptophan (TRP), adrenocorticotropic hormone (ACTH), kynurenine (KYN), cortisol]. Supplementation with resistant dextrin improved sleep (P < 0.001) and QOL (P < 0.001) significantly. It also caused a significant decrease in levels of endotoxin, HbA1c, IL-18, IL-6, TNF-alpha and a significant increase in IL-10 levels. Significant and positive correlations were found between endotoxin (r = 0.488, P = 0.003), IL-6 (r = 0.436, P = 0.008), IL-18 (r = 0.475, P = 0.003), cortisol (r = 0.545, P = 0.048), KYN/TRP (r = 0.527, P = 0.001), and PSQI scores.
+
+ CONCLUSIONS: It is concluded that resistant dextrin improves sleep and QOL in obese women with type 2 diabetes. Its beneficial effects may be attributed in part to modulation of glycemia, metabolic endotoxemia and subsequently a decrease in biomarkers of inflammation and HPA axis activity. © 2022 Society of Chemical Industry. Copyright © 2022 Society of Chemical Industry.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dextrins). 0 (Endotoxins). 0 (Glycated Hemoglobin A). 0 (Interleukin-18). 0 (Interleukin-6). 0 (Prebiotics). 0 (Tumor Necrosis Factor-alpha). 130068-27-8 (Interleukin-10). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2fjsfa.11876
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Saleh-Ghadimi&issn=0022-5142&title=Journal+of+the+Science+of+Food+%26+Agriculture&atitle=Improvement+of+sleep+by+resistant+dextrin+prebiotic+in+type+2+diabetic+women+coincides+with+attenuation+of+metabolic+endotoxemia%3A+involvement+of+gut-brain+axis.&volume=102&issue=12&spage=5229&epage=5237&date=2022&doi=10.1002%2Fjsfa.11876&pmid=35306660&sid=OVID:medline
+
+<544>
+Unique Identifier
+ 35306583
+Title
+ Characterization of metabolites and biomarkers for the probiotic effects of Clostridium cochlearium on high-fat diet-induced obese C57BL/6 mice.
+Source
+ European Journal of Nutrition. 61(4):2217-2229, 2022 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang F; Zhu W; Edirisuriya P; Ai Q; Nie K; Ji X; Zhou K
+Author NameID
+ Zhou, Kequan; ORCID: http://orcid.org/0000-0002-0988-5971
+Authors Full Name
+ Yang, Fei; Zhu, Wenjun; Edirisuriya, Paba; Ai, Qing; Nie, Kai; Ji, Xiangming; Zhou, Kequan.
+Institution
+ Yang, Fei. Department of Nutrition and Food Science, Wayne State University, Detroit, MI, 48202, USA.
+ Zhu, Wenjun. Department of Nutrition and Food Science, Wayne State University, Detroit, MI, 48202, USA.
+ Edirisuriya, Paba. Department of Nutrition and Food Science, Wayne State University, Detroit, MI, 48202, USA.
+ Ai, Qing. Department of Nutrition and Food Science, Wayne State University, Detroit, MI, 48202, USA.
+ Nie, Kai. Department of Nutrition and Food Science, Wayne State University, Detroit, MI, 48202, USA.
+ Ji, Xiangming. Byrdine F. Lewis College of Nursing and Health Professions, Georgia State University, Atlanta, GA, 30303, USA.
+ Zhou, Kequan. Department of Nutrition and Food Science, Wayne State University, Detroit, MI, 48202, USA. kzhou@wayne.edu.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Body Weight
+ Clostridium
+ Diet, High-Fat/ae [Adverse Effects]
+ Fatty Acids, Volatile
+ *Insulin Resistance
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ Obesity
+ *Probiotics
+Keyword Heading
+ Body weight control
+ C. cochlearium
+ High-fat diet-induced obese C57BL/6 mice
+ Insulin sensitivity
+ Metabolomic analysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Probiotic species of butyrate producers have been investigated for the potential in preventing and treating obesity and overweight. However, Clostridium cochlearium has not been linked with any health benefits. We hypothesized that C. cochlearium could be a promising new probiotic with health benefits in improving body weight control and insulin sensitivity.
+
+ METHODS: Productions of short-chain fatty acids (SCFAs) were characterized for C. cochlearium by NMR and GC-MS analyses. Probiotic effects of C. cochlearium were evaluated through diet-induced obese (DIO) C57BL/6 mice. The influence of C. cochlearium administration on gut SCFAs was measured using GC-MS. LC-MS-based untargeted metabolomic profiling and multivariate analysis were used to assess the serum metabolic alteration, identify biomarkers and pathways in response to the C. cochlearium administration.
+
+ RESULTS: After 17 weeks of diet intervention, body weight gain of CC group (fed with a high-fat diet supplemented with C. cochlearium) showed a 21.86% reduction from the high-fat diet (HF) control group (P < 0.001), which was specifically reflected on the significantly lowered fat mass (CC vs HF, 17.19 g vs 22.86 g, P < 0.0001) and fat percentage (CC vs HF, 41.25% vs 47.10%, P < 0.0001), and increased lean percentage (CC vs HF, 46.63% vs 43.72%, P < 0.05). C. cochlearium administration significantly reduced fasting blood glucose from week 8 (P < 0.05 or 0.01), and eventually improved insulin sensitivity (HOMA-IR, CC vs HF, 63.77 vs 143.13, P < 0.05). Overall lowered levels of SCFAs were observed in the gut content of CC group. Metabolomic analysis enabled the identification of 53 discriminatory metabolites and 24 altered pathways between CC and HF groups. In particularly, most of the pathway-matched metabolites showed positive correlations with body weight, which included glutamate, phenylalanine, ornithine, PCs, LPCs, AcCas, proline, 5,6-dihydrouracil, pyroglutamic acid, and 1-pyrroline-4-hydroxy-2-carboxylate.
+
+ CONCLUSIONS: The beneficial effects of C. cochlearium could be related to its ability to restore certain obesity-driven biomarkers and pathways, especially downregulating pathways related to specific amino acids, PCs, LPCs and AcCas. Further research is warranted to investigate related metabolites and metabolic pathways. C. cochlearium may be developed as a promising new probiotic for the prevention or alleviation of obesity and diabetes in human. Copyright © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Volatile).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs00394-022-02840-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=1436-6207&title=European+Journal+of+Nutrition&atitle=Characterization+of+metabolites+and+biomarkers+for+the+probiotic+effects+of+Clostridium+cochlearium+on+high-fat+diet-induced+obese+C57BL%2F6+mice.&volume=61&issue=4&spage=2217&epage=2229&date=2022&doi=10.1007%2Fs00394-022-02840-z&pmid=35306583&sid=OVID:medline
+
+<545>
+Unique Identifier
+ 35306495
+Title
+ Higher Inflammation Is Associated with Cardiometabolic Phenotype and Biochemical Health in Women with Obesity.
+Source
+ Annals of Nutrition & Metabolism. 78(3):177-182, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Killeen SL; Byrne DF; Geraghty AA; Kilbane MT; Twomey PJ; McKenna MJ; Yelverton CA; Saldova R; Van Sinderen D; Cotter PD; Murphy EF; McAuliffe FM
+Authors Full Name
+ Killeen, Sarah Louise; Byrne, David F; Geraghty, Aisling A; Kilbane, Mark T; Twomey, Patrick J; McKenna, Malachi J; Yelverton, Cara A; Saldova, Radka; Van Sinderen, Douwe; Cotter, Paul D; Murphy, Eileen F; McAuliffe, Fionnuala M.
+Institution
+ Killeen, Sarah Louise. UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland, sarah.louise.killeen@ucdconnect.ie.
+ Byrne, David F. UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
+ Geraghty, Aisling A. UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
+ Kilbane, Mark T. Department of Clinical Chemistry, St Vincent's University Hospital, Dublin, Ireland.
+ Twomey, Patrick J. Department of Clinical Chemistry, St Vincent's University Hospital, Dublin, Ireland.
+ McKenna, Malachi J. UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
+ McKenna, Malachi J. Department of Clinical Chemistry, St Vincent's University Hospital, Dublin, Ireland.
+ Yelverton, Cara A. UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
+ Saldova, Radka. The National Institute for Bioprocessing, Research, and Training (NIBRT), Dublin, Ireland.
+ Saldova, Radka. UCD School of Medicine, College of Health and Agricultural Science (CHAS), University College Dublin (UCD), Dublin, Ireland.
+ Van Sinderen, Douwe. APC Microbiome Ireland, National University of Ireland, Cork, Ireland.
+ Van Sinderen, Douwe. School of Microbiology, National University of Ireland, Cork, Ireland.
+ Cotter, Paul D. APC Microbiome Ireland, National University of Ireland, Cork, Ireland.
+ Cotter, Paul D. Teagasc Food Research Centre, Moorepark, Cork, Ireland.
+ Murphy, Eileen F. PrecisionBiotics Group Ltd., Cork Airport Business Park, Cork, Ireland.
+ McAuliffe, Fionnuala M. UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ C-Reactive Protein
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Cross-Sectional Studies
+ Female
+ Humans
+ Inflammation
+ *Metabolic Syndrome
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Phenotype
+ Risk Factors
+Keyword Heading
+ Inflammation
+ Metabolic health
+ Obesity
+ Women's health
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Metabolic or inflammatory markers may predict adverse outcomes in women with obesity. We sought to describe metabolic-obesity phenotypes of women using novel staging tools and investigate relationships with inflammation.
+
+ METHODS: In a cross-sectional study, we collected fasting blood samples from sixty-four females with body mass index (BMI) >=28 kg/m2. Participants were classified as metabolically healthy or metabolically unhealthy obesity (MUO) using the cardiometabolic disease staging system (CMDS) and Edmonton obesity staging system (EOSS). Data were analyzed using independent sample t tests, Pearson's correlations, and multiple logistic regression.
+
+ RESULTS: Mean (SD) age was 40.2 (9.3) years with median (IQR) BMI 31.8 (30.3-35.7) kg/m2. The prevalence of MUO was 46.9% and 81.3% using CMDS and EOSS criteria, respectively. Women with raised CMDS scores had higher C3 (1.34 [0.20] vs. 1.18 [0.15], p = 0.001) and C-reactive protein (CRP) (2.89 [1.31-7.61] vs. 1.39 [0.74-3.60], p = 0.034). C3 correlated with insulin (r = 0.52), hemoglobin A1c (r = 0.37), and C-peptide (r = 0.58), all p < 0.05. C3 above the median (>1.23 g/L) increased odds of raised CMDS score, when controlled for age, BMI, ethnicity, and smoking (OR = 6.56, 95% CI: 1.63, 26.47, p = 0.008).
+
+ CONCLUSION: The prevalence of MUO was lower using CMDS than EOSS. C3 and CRP may be useful clinical biomarkers of risk or treatment targets in women with obesity. Copyright © 2022 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1159%2f000522564
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Killeen&issn=0250-6807&title=Annals+of+Nutrition+%26+Metabolism&atitle=Higher+Inflammation+Is+Associated+with+Cardiometabolic+Phenotype+and+Biochemical+Health+in+Women+with+Obesity.&volume=78&issue=3&spage=177&epage=182&date=2022&doi=10.1159%2F000522564&pmid=35306495&sid=OVID:medline
+
+<546>
+Unique Identifier
+ 35289404
+Title
+ Effects of periodontitis and periodontal treatment on systemic inflammatory markers and metabolic profile in obese and non-obese rats.
+Source
+ Journal of Periodontology. 93(9):1411-1420, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pereira KKY; Jara CM; Antunes GL; Gomes MS; Rosing CK; Cavagni J; Haas AN
+Author NameID
+ Gomes, Maximiliano Schunke; ORCID: https://orcid.org/0000-0002-0394-5400
+ Haas, Alex Nogueira; ORCID: https://orcid.org/0000-0003-0531-6234
+Authors Full Name
+ Pereira, Karina Kimiko Yamashina; Jara, Cynthia Mireya; Antunes, Gessica Luana; Gomes, Maximiliano Schunke; Rosing, Cassiano Kuchenbecker; Cavagni, Juliano; Haas, Alex Nogueira.
+Institution
+ Pereira, Karina Kimiko Yamashina. Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
+ Pereira, Karina Kimiko Yamashina. School of Health and Life Sciences, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil.
+ Jara, Cynthia Mireya. School of Health and Life Sciences, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil.
+ Jara, Cynthia Mireya. Faculty of Dentistry, National University of Assuncion, Assuncion, Paraguay.
+ Antunes, Gessica Luana. School of Health and Life Sciences, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil.
+ Gomes, Maximiliano Schunke. School of Health and Life Sciences, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil.
+ Gomes, Maximiliano Schunke. Medical and Dental Center of the Military Police of Rio Grande do Sul, Porto Alegre, Brazil.
+ Rosing, Cassiano Kuchenbecker. Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
+ Cavagni, Juliano. Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
+ Haas, Alex Nogueira. Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ C-Reactive Protein/an [Analysis]
+ Cholesterol
+ Glucose
+ Interleukin-10/me [Metabolism]
+ *Interleukin-10
+ Interleukin-17/me [Metabolism]
+ Interleukin-6/me [Metabolism]
+ Male
+ Metabolome
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Periodontitis/co [Complications]
+ Periodontitis/th [Therapy]
+ *Periodontitis
+ Rats
+ Rats, Wistar
+ Silk/me [Metabolism]
+ Triglycerides
+ Tumor Necrosis Factor-alpha/me [Metabolism]
+Keyword Heading
+ inflammation
+ obesity
+ periodontitis
+ rats
+ scaling and root planing
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Little is known about a synergistic effect of periodontitis and obesity on systemic biomarkers and a possible effect periodontal treatment may exert. This study aimed to evaluate the impact of periodontitis and periodontal treatment on systemic inflammation and metabolic profile in obese and non-obese rats.
+
+ METHODS: Sixty male Wistar rats were randomly divided in six groups differentiated by diet and periodontal status: no periodontitis (G1 and G4), untreated ligature-induced periodontitis (G2 and G5), and treated ligature-induced periodontitis (G3 and G6). Groups G4, G5, and G6 were exposed to cafeteria diet to induce obesity. Periodontitis was induced by silk ligatures over 4 weeks (G2, G3, G5, and G6). Rats in G3 and G6 received scaling and root planing and were followed for additional 4 weeks. After sacrifice, serum levels of C-reactive protein (CRP), interleukin (IL)-1beta, IL-6, IL-10, IL-17a, tumor necrosis factor alfa (TNF-alpha), glucose, triglycerides, and total cholesterol (TC) were compared between groups.
+
+ RESULTS: CRP was significantly higher in obese rats with than without periodontitis (G5 = 10.15 versus G4 = 4.47 mug/L, P = 0.01). No beneficial effects of periodontal treatment were observed for CRP levels, IL-6, IL-1beta, IL-17a, and TNF-alpha, glucose and triglycerides. Treated periodontitis (G6) exhibited significantly lower TC than the periodontitis group (G5) in obese rats.
+
+ CONCLUSION: Periodontitis increased serum CRP in obese rats, indicating a synergistic role of periodontitis in the systemic inflammatory burden triggered by obesity. The treatment of induced periodontitis reduced TC levels in obese rats. Copyright © 2022 American Academy of Periodontology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-17). 0 (Interleukin-6). 0 (Silk). 0 (Triglycerides). 0 (Tumor Necrosis Factor-alpha). 130068-27-8 (Interleukin-10). 9007-41-4 (C-Reactive Protein). 97C5T2UQ7J (Cholesterol). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2fJPER.21-0575
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pereira&issn=0022-3492&title=Journal+of+Periodontology&atitle=Effects+of+periodontitis+and+periodontal+treatment+on+systemic+inflammatory+markers+and+metabolic+profile+in+obese+and+non-obese+rats.&volume=93&issue=9&spage=1411&epage=1420&date=2022&doi=10.1002%2FJPER.21-0575&pmid=35289404&sid=OVID:medline
+
+<547>
+Unique Identifier
+ 35286051
+Title
+ Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women.
+Source
+ Journal of Basic & Clinical Physiology & Pharmacology. 33(6):769-777, 2022 Nov 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rejeki PS; Baskara PG; Herawati L; Pranoto A; Setiawan HK; Lesmana R; Halim S
+Authors Full Name
+ Rejeki, Purwo Sri; Baskara, Pradika Gita; Herawati, Lilik; Pranoto, Adi; Setiawan, Hayuris Kinandita; Lesmana, Ronny; Halim, Shariff.
+Institution
+ Rejeki, Purwo Sri. Department of Medical Physiology and Biochemistry, Physiology Division, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
+ Baskara, Pradika Gita. Sport Health Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
+ Herawati, Lilik. Department of Medical Physiology and Biochemistry, Physiology Division, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
+ Pranoto, Adi. Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
+ Setiawan, Hayuris Kinandita. Department of Medical Physiology and Biochemistry, Physiology Division, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
+ Lesmana, Ronny. Department of Biomedical Science, Physiology Division, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
+ Halim, Shariff. Clinical Research Centre, Management and Science University, Shah Alam, Malaysia.
+MeSH Subject Headings
+ Humans
+ Female
+ Young Adult
+ Adult
+ Angiopoietin-like Proteins
+ Angiopoietin-Like Protein 8
+ Peptide Hormones/me [Metabolism]
+ *Peptide Hormones
+ Obesity/me [Metabolism]
+ Biomarkers
+ Exercise
+ *Insulin Resistance
+Keyword Heading
+ betatrophin
+ moderate-intensity exercise
+ myokine
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Positive energy homeostasis due to overnutrition and a sedentary lifestyle triggers obesity. Obesity has a close relationship with elevated levels of betatrophin and may increase the risk of developing metabolic syndrome. Therefore, lifestyle modification through a nonpharmacological approach based on physical exercise is the right strategy in lowering betatrophin levels. This study aimed to analyze the effect of moderate-intensity interval and continuous exercises on decreased betatrophin levels and the association between betatrophin levels and obesity markers in women.
+
+ METHODS: A total of 30 women aged 20-24 years old were randomly divided into three groups. Measurement of betatrophin levels using Enzyme-Linked Immunosorbent Assay (ELISA). Data analysis techniques used were one-way ANOVA and parametric linear correlation.
+
+ RESULTS: The results showed that the average levels of betatrophin pre-exercise were 200.40 +/- 11.03 pg/mL at CON, 203.07 +/- 42.48 pg/mL at MIE, 196.62 +/- 21.29 pg/mL at MCE, and p=0.978. Average levels of betatrophin post-exercise were 226.65 +/- 18.96 pg/mL at CON, 109.31 +/- 11.23 pg/mL at MIE, 52.38 +/- 8.18 pg/mL at MCE, and p=0.000. Pre-exercise betatrophin levels were positively correlated with age, BMI, FM, WHR, FBG, and PBF (p<=0.001).
+
+ CONCLUSIONS: Our study showed that betatrophin levels are decreased by 10 min post-MIE and post-MCE. However, moderate-intensity continuous exercise is more effective in lowering betatrophin levels than moderate-intensity interval exercise. In addition, pre-exercise betatrophin levels also have a positive correlation with obesity markers. Copyright © 2022 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Angiopoietin-like Proteins). 0 (Angiopoietin-Like Protein 8). 0 (Peptide Hormones). 0 (Biomarkers).
+Publication Type
+ Randomized Controlled Trial. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1515%2fjbcpp-2021-0393
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rejeki&issn=0792-6855&title=Journal+of+Basic+%26+Clinical+Physiology+%26+Pharmacology&atitle=Moderate-intensity+exercise+decreases+the+circulating+level+of+betatrophin+and+its+correlation+among+markers+of+obesity+in+women.&volume=33&issue=6&spage=769&epage=777&date=2022&doi=10.1515%2Fjbcpp-2021-0393&pmid=35286051&sid=OVID:medline
+
+<548>
+Unique Identifier
+ 35283347
+Title
+ High early pregnancy body mass index is associated with alterations in first- and second-trimester angiogenic biomarkers.
+Source
+ American Journal of Obstetrics & Gynecology MFM. 4(3):100614, 2022 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Beck C; Allshouse A; Silver RM; Grobman WA; Simhan H; Haas D; Reddy UM; Blue NR
+Authors Full Name
+ Beck, Celeste; Allshouse, Amanda; Silver, Robert M; Grobman, William A; Simhan, Hyagriv; Haas, David; Reddy, Uma M; Blue, Nathan R.
+Institution
+ Beck, Celeste. Department of Nutritional Sciences, Pennsylvania State University, State College, PA (Ms Beck). Electronic address: beckceleste@gmail.com.
+ Allshouse, Amanda. Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT (Ms Allshouse and Drs Silver and Blue).
+ Silver, Robert M. Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT (Ms Allshouse and Drs Silver and Blue); Department of Maternal-Fetal Medicine, Intermountain Healthcare, Salt Lake City, UT (Drs Silver and Blue).
+ Grobman, William A. Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL (Dr Grobman).
+ Simhan, Hyagriv. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA (Dr Simhan).
+ Haas, David. Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN (Dr Haas).
+ Reddy, Uma M. Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT (Dr Reddy).
+ Blue, Nathan R. Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT (Ms Allshouse and Drs Silver and Blue); Department of Maternal-Fetal Medicine, Intermountain Healthcare, Salt Lake City, UT (Drs Silver and Blue).
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Female
+ Humans
+ Infant, Newborn
+ Male
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Overweight
+ Placenta
+ Placenta Growth Factor
+ Pre-Eclampsia/di [Diagnosis]
+ Pre-Eclampsia/ep [Epidemiology]
+ Pre-Eclampsia/et [Etiology]
+ *Pre-Eclampsia
+ Pregnancy
+ Pregnancy Trimester, Second
+ *Premature Birth
+ Prospective Studies
+ Stillbirth
+ Vascular Endothelial Growth Factor A
+ Vascular Endothelial Growth Factor Receptor-1
+Keyword Heading
+ angiogenic biomarkers, body mass index, maternal obesity, placental dysfunction, placental growth factor, soluble fms-like tyrosine kinase-1, soluble fms-like tyrosine kinase-1-to-placental growth factor ratio
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is associated with various placenta-mediated adverse pregnancy outcomes, including preeclampsia, preterm birth, and stillbirth. Mechanisms linking obesity with placental dysfunction are not completely understood.
+
+ OBJECTIVE: This study aimed to examine the relationship between early pregnancy body mass index and placental angiogenic biomarkers soluble fms-like tyrosine kinase-1, placental growth factor, and the soluble fms-like tyrosine kinase-1-to-placental growth factor ratio.
+
+ STUDY DESIGN: We conducted secondary analyses of an existing substudy within a multisite, prospective observational cohort study of nulliparous pregnant women in the United States. First- and second-trimester maternal blood samples, first-trimester body mass index, and demographic, lifestyle, and pregnancy outcomes data were collected. Soluble fms-like tyrosine kinase-1 and placental growth factor concentrations were measured at 6 to 13 and 16 to 22 weeks of gestation for women (cases) who experienced one of several adverse pregnancy outcomes (delivery at <37 weeks of gestation, preeclampsia or eclampsia, birthweight for gestational age <5th percentile, or stillbirth) and for those who had none of those outcomes (controls). We used multivariable mixed-effects linear regression models to estimate the association of body mass index with angiogenic biomarkers at both time points. We evaluated mean change between first- and second-trimester biomarker concentrations using multivariable linear regression models. Lastly, we used logistic regression models to estimate the risk of a high second-trimester soluble fms-like tyrosine kinase-1-to-placental growth factor ratio, using clinically established cutoffs for risk prediction.
+
+ RESULTS: Angiogenic biomarker and early pregnancy body mass index data were available for 2363 women (1467 with adverse pregnancy outcomes and 896 controls). High early pregnancy body mass index was associated with consistently lower soluble fms-like tyrosine kinase-1 concentrations across the first and second trimesters of pregnancy. We found lower first-trimester placental growth factor concentrations in the group with class II or III obesity (P<.001) and lower second-trimester placental growth factor concentrations among groups who were overweight, with class I obesity, and class II or III obesity (P<.001). For every unit increase in early pregnancy body mass index, there was a -4.4 pg/mL (95% confidence interval, -3.6 to -5.2) smaller mean increase in placental growth factor concentrations between the first and second trimesters of pregnancy. These differences resulted in significantly lower mean first-trimester soluble fms-like tyrosine kinase-1-to-placental growth factor ratios among groups who were overweight, with class I obesity, and class II or III obesity (P<.05) and in a significantly higher second-trimester soluble fms-like tyrosine kinase-1-to-placental growth factor ratio among the group with class II or III obesity (P<.001), compared with the group with normal body mass index. Each unit of increase in body mass index was associated with a 0.5 (95% confidence interval, 0.3-0.7) greater mean increase in the soluble fms-like tyrosine kinase-1-to-placental growth factor ratio between the first and second trimesters of pregnancy. In stratified analyses, associations between body mass index and angiogenic biomarkers soluble fms-like tyrosine kinase-1 and placental growth factor were similar in nonadverse pregnancy outcome and adverse pregnancy outcome subgroups, whereas associations between body mass index and the soluble fms-like tyrosine kinase-1-to-placental growth factor ratio were attenuated in the subgroups. Participants in the group with class II or III obesity were 3.13 (95% confidence interval, 1.15-8.49) times more likely than participants with normal weight to have a second-trimester ratio of >=38 in univariate analysis.
+
+ CONCLUSION: High early pregnancy body mass index was associated with lower soluble fms-like tyrosine kinase-1 and placental growth factor concentrations across early pregnancy. Maternal body mass was inversely associated with first-trimester soluble fms-like tyrosine kinase-1-to-placental growth factor ratios and positively associated with second-trimester soluble fms-like tyrosine kinase-1-to-placental growth factor ratios, driven by a diminished rise in placental growth factor between the first and second trimesters of pregnancy. Women with class II or III obesity have an increased risk of a high second-trimester soluble fms-like tyrosine kinase-1-to-placental growth factor ratio associated with placental dysfunction. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Vascular Endothelial Growth Factor A). 144589-93-5 (Placenta Growth Factor). EC 2-7-10-1 (Vascular Endothelial Growth Factor Receptor-1).
+Publication Type
+ Journal Article. Observational Study. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.ajogmf.2022.100614
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Beck&issn=2589-9333&title=American+Journal+of+Obstetrics+%26+Gynecology+MFM&atitle=High+early+pregnancy+body+mass+index+is+associated+with+alterations+in+first-+and+second-trimester+angiogenic+biomarkers.&volume=4&issue=3&spage=100614&epage=&date=2022&doi=10.1016%2Fj.ajogmf.2022.100614&pmid=35283347&sid=OVID:medline
+
+<549>
+Unique Identifier
+ 35277002
+Title
+ IL-17A, IL-17E and IL-17F as Potential Biomarkers for the Intensity of Low-Grade Inflammation and the Risk of Cardiovascular Diseases in Obese People.
+Source
+ Nutrients. 14(3), 2022 Feb 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Polak-Szczybylo E; Tabarkiewicz J
+Author NameID
+ Tabarkiewicz, Jacek; ORCID: https://orcid.org/0000-0002-1264-2882
+Authors Full Name
+ Polak-Szczybylo, Ewelina; Tabarkiewicz, Jacek.
+Institution
+ Polak-Szczybylo, Ewelina. Department of Dietetics, Institute of Health Sciences, Medical College of Rzeszow University, University of Rzeszow, 35-959 Rzeszow, Poland.
+ Tabarkiewicz, Jacek. Department of Human Immunology, Institute of Medical Sciences, Medical College of Rzeszow University, University of Rzeszow, 35-959 Rzeszow, Poland.
+ Tabarkiewicz, Jacek. Laboratory for Translational Research in Medicine, Centre for Innovative Research in Medical and Natural Sciences, Medical College of Rzeszow University, University of Rzeszow, 35-959 Rzeszow, Poland.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Humans
+ Inflammation/co [Complications]
+ Inflammation/di [Diagnosis]
+ *Inflammation
+ *Interleukin-17
+ Obesity/co [Complications]
+ *Obesity
+Keyword Heading
+ IL-17A
+ IL-17E
+ IL-17F
+ cardiovascular disease
+ low-grade inflammation
+ metabolic syndrome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Low-grade inflammation is a factor that predisposes to many obesity-related comorbidities. The immune mechanisms controlling the inflammatory response related to the secretory activity of adipocytes and its consequences for the organism are still under investigation.
+
+ METHODS: 84 obese adult volunteers (BMI >= 30 kg/m2) were tested by BIA. Serum samples were collected to analyze the concentrations of interleukins IL-17A, IL-17E and IL-17F. The subjects completed the original questionnaire, the FFQ-6 food consumption frequency questionnaire and the food diary.
+
+ RESULTS: The level of IL-17E and IL-17F was positively correlated with the BMI value and the level of IL-17E increased with the content of subcutaneous fat. Its increased blood concentration was also observed in individuals who declared that they were diagnosed with atherosclerosis and/or were taking beta-blockers. Products that were related with a low level of the above-mentioned interleukins were vegetables, groats, eggs, red meat, fast-food and alcohol. The level of these interleukins was positively correlated with the frequent consumption of confectionery and breakfast cereals. Nutrients that decreased the concentrations of IL-17 isoforms were potassium, iron, vitamins B6 and C, and folic acid.
+
+ CONCLUSIONS: Both IL-17E and IL-17F may be closely related to the intensity of low-grade inflammation and be biomarkers of cardiovascular disease risk. Food products or the nutrients they contain may affect the levels of the above-mentioned interleukins as well as IL-17A.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-17).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fnu14030643
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Polak-Szczybylo&issn=2072-6643&title=Nutrients&atitle=IL-17A%2C+IL-17E+and+IL-17F+as+Potential+Biomarkers+for+the+Intensity+of+Low-Grade+Inflammation+and+the+Risk+of+Cardiovascular+Diseases+in+Obese+People.&volume=14&issue=3&spage=&epage=&date=2022&doi=10.3390%2Fnu14030643&pmid=35277002&sid=OVID:medline
+
+<550>
+Unique Identifier
+ 35271405
+Title
+ Fecal microbiota of adolescent and young adult cancer survivors and metabolic syndrome: an exploratory study.
+Source
+ Pediatric Hematology & Oncology. 39(7):629-643, 2022 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rotz SJ; Sangwan N; Nagy M; Tzeng A; Jia M; Moncaliano M; Majhail NS; Eng C
+Author NameID
+ Rotz, Seth J; ORCID: https://orcid.org/0000-0003-2896-1113
+ Eng, Charis; ORCID: https://orcid.org/0000-0002-3693-5145
+Authors Full Name
+ Rotz, Seth J; Sangwan, Naseer; Nagy, Matthew; Tzeng, Alice; Jia, Margaret; Moncaliano, Maria; Majhail, Navneet S; Eng, Charis.
+Institution
+ Rotz, Seth J. Department of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, Cleveland Clinic Children's Hospital, Cleveland, Ohio, USA.
+ Rotz, Seth J. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine Cleveland, Ohio, USA.
+ Sangwan, Naseer. Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
+ Nagy, Matthew. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine Cleveland, Ohio, USA.
+ Tzeng, Alice. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine Cleveland, Ohio, USA.
+ Tzeng, Alice. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
+ Jia, Margaret. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
+ Moncaliano, Maria. Case Western Reserve University School of Medicine.
+ Majhail, Navneet S. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine Cleveland, Ohio, USA.
+ Majhail, Navneet S. Blood and Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
+ Eng, Charis. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine Cleveland, Ohio, USA.
+ Eng, Charis. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
+ Eng, Charis. Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care and Population Health, Cleveland, Ohio, USA.
+ Eng, Charis. Department of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
+ Eng, Charis. Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
+ Eng, Charis. Germline High Risk Focus Group, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
+MeSH Subject Headings
+ Adiponectin
+ Adolescent
+ Biomarkers
+ C-Reactive Protein
+ *Cancer Survivors
+ Child
+ Cross-Sectional Studies
+ Cytokines
+ Glycated Hemoglobin
+ Humans
+ Interleukin-10
+ Interleukin-6
+ Lectins
+ Leptin
+ *Metabolic Syndrome
+ *Microbiota
+ Obesity
+ Tumor Necrosis Factor-alpha
+ Young Adult
+Keyword Heading
+ AYA
+ dysbiosis
+ inflammation
+ late-effects
+ metabolic syndrome
+ microbiome
+ survivor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Metabolic syndrome and obesity occur commonly in long-term pediatric cancer survivors. The intestinal microbiome is associated with metabolic syndrome and obesity in the general population, and is perturbed during cancer therapy. We aimed to determine if long-term survivors of pediatric cancer would have reduced bacterial microbiome diversity, and if these findings would be associated with components of the metabolic syndrome, obesity, and chronic inflammation. We performed a cross-sectional exploratory study examining the intestinal microbiome via 16S amplicon sequencing, treatment history, clinical measurements (blood pressure, body mass index) and biomarkers (hemoglobin A1c, lipoproteins, adiponectin: leptin ratio, C-reactive protein, TNFalpha, Interleukin-6, and Interleukin-10) between 35 long-term survivors and 32 age, sex, and race matched controls. All subjects were aged 10-40 years, and survivors were at least five years from therapy completion. Survivors had lower alpha diversity compared to controls (Shannon index p = .001, Simpson index p = .032) and differently abundant bacterial taxa. Further, among survivors, those who received radiation (18/35) to the central nervous system or abdomen/pelvis had decreased alpha diversity compared to those who did not receive radiation (Shannon and Simpson p < .05 for both). Although, no specific component of metabolic syndrome or cytokine was associated with measures of alpha diversity, survivors with low adiponectin-lectin ratio, elevated body mass index, and elevated C-reactive protein had differently abundant taxa compared to those with normal measures. The microbiome of cancer survivors remains less diverse than controls even many years after diagnosis, and exposure to radiation may lead to further loss of diversity in survivors.Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2022.2049937.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Cytokines). 0 (Glycated Hemoglobin A). 0 (Interleukin-6). 0 (Lectins). 0 (Leptin). 0 (Tumor Necrosis Factor-alpha). 130068-27-8 (Interleukin-10). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f08880018.2022.2049937
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rotz&issn=0888-0018&title=Pediatric+Hematology+%26+Oncology&atitle=Fecal+microbiota+of+adolescent+and+young+adult+cancer+survivors+and+metabolic+syndrome%3A+an+exploratory+study.&volume=39&issue=7&spage=629&epage=643&date=2022&doi=10.1080%2F08880018.2022.2049937&pmid=35271405&sid=OVID:medline
+
+<551>
+Unique Identifier
+ 35267977
+Title
+ Malnutrition and Biomarkers: A Journey through Extracellular Vesicles. [Review]
+Source
+ Nutrients. 14(5), 2022 Feb 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mendivil-Alvarado H; Sosa-Leon LA; Carvajal-Millan E; Astiazaran-Garcia H
+Author NameID
+ Carvajal-Millan, Elizabeth; ORCID: https://orcid.org/0000-0003-4390-7457
+ Astiazaran-Garcia, Humberto; ORCID: https://orcid.org/0000-0002-2452-0057
+Authors Full Name
+ Mendivil-Alvarado, Herminia; Sosa-Leon, Leopoldo Alberto; Carvajal-Millan, Elizabeth; Astiazaran-Garcia, Humberto.
+Institution
+ Mendivil-Alvarado, Herminia. Department of Nutrition, Research Center for Food and Development, CIAD, A.C., Hermosillo 83304, Mexico.
+ Sosa-Leon, Leopoldo Alberto. Independent Researcher, Hermosillo 83304, Mexico.
+ Carvajal-Millan, Elizabeth. Biopolymers, Research Center for Food and Development, CIAD, A.C., Hermosillo 83304, Mexico.
+ Astiazaran-Garcia, Humberto. Department of Nutrition, Research Center for Food and Development, CIAD, A.C., Hermosillo 83304, Mexico.
+ Astiazaran-Garcia, Humberto. Department of Chemical and Biological Sciences, University of Sonora, Hermosillo 83000, Mexico.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Cell Communication/ph [Physiology]
+ Extracellular Vesicles/me [Metabolism]
+ *Extracellular Vesicles
+ Humans
+ Malnutrition/me [Metabolism]
+ *Malnutrition
+ Obesity/me [Metabolism]
+Keyword Heading
+ exosomes
+ microparticles
+ microvesicles
+ obesity
+ undernutrition
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Extracellular vesicles (EVs) have been identified as active components in cellular communication, which are easily altered both morphologically and chemically by the cellular environment and metabolic state of the body. Due to this sensitivity to the conditions of the cellular microenvironment, EVs have been found to be associated with disease conditions, including those associated with obesity and undernutrition. The sensitivity that EVs show to changes in the cellular microenvironment could be a reflection of early cellular alterations related to conditions of malnutrition, which could eventually be used in the routine monitoring and control of diseases or complications associated with it. However, little is known about the influence of malnutrition alone; that is, without the influence of additional diseases on the heterogeneity and specific content of EVs. To date, studies in "apparently healthy" obese patients show that there are changes in the size, quantity, and content of EVs, as well as correlations with some metabolic parameters (glucose, insulin, and serum lipids) in comparison with non-obese individuals. In light of these changes, a direct participation of EVs in the development of metabolic and cardiovascular complications in obese subjects is thought to exist. However, the mechanisms through which this process might occur are not yet fully understood. The evidence on EVs in conditions of undernutrition is limited, but it suggests that EVs play a role in the maintenance of homeostasis and muscle repair. A better understanding of how EVs participate in or promote cellular signaling in malnutrition conditions could help in the development of new strategies to treat them and their comorbidities.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fnu14051002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mendivil-Alvarado&issn=2072-6643&title=Nutrients&atitle=Malnutrition+and+Biomarkers%3A+A+Journey+through+Extracellular+Vesicles.&volume=14&issue=5&spage=&epage=&date=2022&doi=10.3390%2Fnu14051002&pmid=35267977&sid=OVID:medline
+
+<552>
+Unique Identifier
+ 35266657
+Title
+ Integrative global co-expression analysis identifies key microRNA-target gene networks as key blood biomarkers for obesity.
+Source
+ Minerva Medica. 113(3):532-541, 2022 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bima AI; Elsamanoudy AZ; Alamri AS; Felimban R; Felemban M; Alghamdi KS; Kaipa PR; Elango R; Shaik NA; Banaganapalli B
+Authors Full Name
+ Bima, Abdulhadi I; Elsamanoudy, Ayman Z; Alamri, Abdulhakeem S; Felimban, Raed; Felemban, Majed; Alghamdi, Kawthar S; Kaipa, Prabhakar R; Elango, Ramu; Shaik, Noor A; Banaganapalli, Babajan.
+Institution
+ Bima, Abdulhadi I. Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Elsamanoudy, Ayman Z. Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Elsamanoudy, Ayman Z. Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
+ Alamri, Abdulhakeem S. Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, University of Taif, Taif, Saudi Arabia.
+ Alamri, Abdulhakeem S. Center of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, University of Taif, Taif, Saudi Arabia.
+ Felimban, Raed. Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Felimban, Raed. 3D Bioprinting Unit, Center of Innovation in Personalised Medicine (CIPM), King Abdulaziz University, Jeddah, Saudi Arabia.
+ Felemban, Majed. Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Felemban, Majed. Center of Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Alghamdi, Kawthar S. Department of Biology, Faculty of Science, Hafar Al-Batin University, Hafar Al-Batin, Saudi Arabia.
+ Alghamdi, Kawthar S. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Kaipa, Prabhakar R. Department of Genetics, College of Science, Osmania University, Hyderabad, India.
+ Elango, Ramu. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Elango, Ramu. Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Shaik, Noor A. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Shaik, Noor A. Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Banaganapalli, Babajan. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia - bbabajan@kau.edu.sa.
+ Banaganapalli, Babajan. Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+MeSH Subject Headings
+ Biomarkers
+ Computational Biology/mt [Methods]
+ Gene Expression Profiling/mt [Methods]
+ Gene Expression Regulation, Neoplastic
+ *Gene Regulatory Networks
+ Humans
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ Obesity/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+ Transcription Factors/ge [Genetics]
+ Transcription Factors/me [Metabolism]
+Abstract
+ BACKGROUND: Obesity is associated with the quantitative changes in miRNAs and their target genes. However, the molecular basis of their dysregulation and expression status correlations is incompletely understood. Therefore, this study aims to examine the shared differentially expressed miRNAs and their target genes between blood and adipose tissues of obese individuals to identify potential blood-based biomarkers.
+
+ METHODS: In this study, 3 gene expression datasets (two mRNA and one miRNA), generated from blood and adipose tissues of 68 obese and 39 lean individuals, were analyzed by a series of robust computational concepts, like protein interactome mapping, functional enrichment of biological pathways and construction of miRNA-mRNA and transcription factor gene networks.
+
+ RESULTS: The comparison of blood versus tissue datasets has revealed the shared differential expression of 210 genes (59.5% upregulated) involved in lipid metabolism and inflammatory reactions. The blood miRNA (GSE25470) analysis has identified 79 differentially expressed miRNAs (71% downregulated). The miRNA-target gene scan identified regulation of 30 shared genes by 22miRNAs. The gene network analysis has identified the inverse expression correlation between 8 target genes (TP53, DYSF, GAB2, GFRA2, NACC2, FAM53C, JNK and GAB2) and 3 key miRNAs (hsa-mir-940, hsa-mir-765, hsa-mir-612), which are further regulated by 24 key transcription factors.
+
+ CONCLUSIONS: This study identifies potential obesity related blood biomarkers from large-scale gene expression data by computational miRNA-target gene interactome and transcription factor network construction methods.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN765 microRNA, human). 0 (MicroRNAs). 0 (RNA, Messenger). 0 (Transcription Factors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.23736%2fS0026-4806.21.07478-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bima&issn=0026-4806&title=Minerva+Medica&atitle=Integrative+global+co-expression+analysis+identifies+key+microRNA-target+gene+networks+as+key+blood+biomarkers+for+obesity.&volume=113&issue=3&spage=532&epage=541&date=2022&doi=10.23736%2FS0026-4806.21.07478-4&pmid=35266657&sid=OVID:medline
+
+<553>
+Unique Identifier
+ 35254638
+Title
+ Triglyceride to high-density lipoprotein cholesterol ratio in adolescence as a predictive marker of metabolic syndrome and obesity in early adulthood in China.
+Source
+ Endocrine. 76(2):331-340, 2022 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhou F; Sun X; Liu J; Li L; Li L; Li P
+Author NameID
+ Li, Ping; ORCID: https://orcid.org/0000-0002-3465-3443
+Authors Full Name
+ Zhou, Fang; Sun, Xiaoshi; Liu, Juan; Li, Linlin; Li, Ling; Li, Ping.
+Institution
+ Zhou, Fang. Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110022, People's Republic of China.
+ Sun, Xiaoshi. Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110022, People's Republic of China.
+ Liu, Juan. Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi 'an Jiaotong University, Xi 'an, Shanxi province, People's Republic of China.
+ Li, Linlin. Department of Academic affairs, Shenyang Open University, Shenyang, China.
+ Li, Ling. Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110022, People's Republic of China.
+ Li, Ping. Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110022, People's Republic of China. s6800@163.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers
+ China/ep [Epidemiology]
+ Cholesterol, HDL
+ Humans
+ *Insulin Resistance
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome
+ Obesity/ep [Epidemiology]
+ Risk Factors
+ Triglycerides
+Keyword Heading
+ Adolescents
+ High-density lipoprotein cholesterol
+ Metabolic syndrome
+ Obesity
+ Triglyceride
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To explore serum triglyceride (TG) to high-density cholesterol (HDL-C) ratio as a diagnostic marker of metabolic syndrome (MetS) in adolescents and its efficacy in predicting MetS and obesity in the early adulthood.
+
+ METHODS: A stratified cluster random sampling method was used to select a total of 935 subjects from senior and junior high schools in Liaoyang, northeast China. The subjects were physically examined and laboratory evaluation was performed. A follow-up examination was performed after 5 years on some (n = 93) of the subjects who had reached adulthood.
+
+ RESULTS: TG/HDL-C had significantly high diagnostic accuracy for MetS than HOMA-IR, TG or HDL-C. Subjects with the highest TG/HDL-C at baseline had higher risk of MetS (odds ratio [OR] = 11.65) and obesity (OR = 4.32) in early adulthood.
+
+ CONCLUSION: TG/HDL-C ratio has a strong and independent ability in diagnosing MetS in adolescents and predicting the occurrence of MetS and obesity in their early adulthood. Copyright © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs12020-022-03014-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhou&issn=1355-008X&title=Endocrine&atitle=Triglyceride+to+high-density+lipoprotein+cholesterol+ratio+in+adolescence+as+a+predictive+marker+of+metabolic+syndrome+and+obesity+in+early+adulthood+in+China.&volume=76&issue=2&spage=331&epage=340&date=2022&doi=10.1007%2Fs12020-022-03014-x&pmid=35254638&sid=OVID:medline
+
+<554>
+Unique Identifier
+ 35247283
+Title
+ Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence.
+Source
+ Journal of Bone & Mineral Research. 37(5):997-1011, 2022 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chandra A; Lagnado AB; Farr JN; Schleusner M; Monroe DG; Saul D; Passos JF; Khosla S; Pignolo RJ
+Author NameID
+ Chandra, Abhishek; ORCID: https://orcid.org/0000-0001-9423-9669
+ Farr, Joshua N; ORCID: https://orcid.org/0000-0002-3179-6414
+ Monroe, David G; ORCID: https://orcid.org/0000-0002-4818-0114
+ Saul, Dominik; ORCID: https://orcid.org/0000-0002-0673-3710
+ Passos, Joao F; ORCID: https://orcid.org/0000-0001-8765-1890
+ Khosla, Sundeep; ORCID: https://orcid.org/0000-0002-2936-4372
+ Pignolo, Robert J; ORCID: https://orcid.org/0000-0002-8533-9438
+Authors Full Name
+ Chandra, Abhishek; Lagnado, Anthony B; Farr, Joshua N; Schleusner, Megan; Monroe, David G; Saul, Dominik; Passos, Joao F; Khosla, Sundeep; Pignolo, Robert J.
+Institution
+ Chandra, Abhishek. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Chandra, Abhishek. Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Chandra, Abhishek. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Lagnado, Anthony B. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Lagnado, Anthony B. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Farr, Joshua N. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Farr, Joshua N. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Farr, Joshua N. Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Schleusner, Megan. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Monroe, David G. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Monroe, David G. Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Saul, Dominik. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Saul, Dominik. Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Passos, Joao F. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Passos, Joao F. Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Passos, Joao F. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Khosla, Sundeep. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Khosla, Sundeep. Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Pignolo, Robert J. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Pignolo, Robert J. Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Pignolo, Robert J. Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.
+ Pignolo, Robert J. Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN, USA.
+MeSH Subject Headings
+ Adiposity
+ Aging
+ Animals
+ Biomarkers
+ Bone Marrow
+ Cellular Senescence
+ Mice
+ Mice, Inbred C57BL
+ *MicroRNAs
+ Obesity
+ *Osteoporosis
+Keyword Heading
+ AGING
+ BONE MARROW ADIPOSITY
+ CELLULAR SENESCENCE
+ P21
+ RADIATION
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Oxidative stress-induced reactive oxygen species, DNA damage, apoptosis, and cellular senescence have been associated with reduced osteoprogenitors in a reciprocal fashion to bone marrow adipocyte tissue (BMAT); however, a direct (causal) link between cellular senescence and BMAT is still elusive. Accumulation of senescent cells occur in naturally aged and in focally radiated bone tissue, but despite amelioration of age- and radiation-associated bone loss after senescent cell clearance, molecular events that precede BMAT accrual are largely unknown. Here we show by RNA-Sequencing data that BMAT-related genes were the most upregulated gene subset in radiated bones of C57BL/6 mice. Using focal radiation as a model to understand age-associated changes in bone, we performed a longitudinal assessment of cellular senescence and BMAT. Using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), RNA in situ hybridization of p21 transcripts and histological assessment of telomere dysfunction as a marker of senescence, we observed an increase in senescent cell burden of bone cells from day 1 postradiation, without the presence of BMAT. BMAT was significantly elevated in radiated bones at day 7, confirming the qRT-PCR data in which most BMAT-related genes were elevated by day 7, and the trend continued until day 42 postradiation. Similarly, elevation in BMAT-related genes was observed in bones of aged mice. The senolytic cocktail of Dasatinib (D) plus Quercetin (Q) (ie, D + Q), which clears senescent cells, reduced BMAT in aged and radiated bones. MicroRNAs (miRNAs or miRs) linked with senescence marker p21 were downregulated in radiated and aged bones, whereas miR-27a, a miR that is associated with increased BMAT, was elevated both in radiated and aged bones. D + Q downregulated miR-27a in radiated bones at 42 days postradiation. Overall, our study provides evidence that BMAT occurrence in oxidatively stressed bone environments, such as radiation and aging, is induced following a common pathway and is dependent on the presence of senescent cells. © 2022 American Society for Bone and Mineral Research (ASBMR). Copyright © 2022 American Society for Bone and Mineral Research (ASBMR).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2fjbmr.4537
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chandra&issn=0884-0431&title=Journal+of+Bone+%26+Mineral+Research&atitle=Bone+Marrow+Adiposity+in+Models+of+Radiation-+and+Aging-Related+Bone+Loss+Is+Dependent+on+Cellular+Senescence.&volume=37&issue=5&spage=997&epage=1011&date=2022&doi=10.1002%2Fjbmr.4537&pmid=35247283&sid=OVID:medline
+
+<555>
+Unique Identifier
+ 35247131
+Title
+ Senescent macrophages in the human adipose tissue as a source of inflammaging.
+Source
+ GeroScience. 44(4):1941-1960, 2022 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Matacchione G; Perugini J; Di Mercurio E; Sabbatinelli J; Prattichizzo F; Senzacqua M; Storci G; Dani C; Lezoche G; Guerrieri M; Giordano A; Bonafe M; Olivieri F
+Author NameID
+ Matacchione, Giulia; ORCID: https://orcid.org/0000-0002-1840-3903
+Authors Full Name
+ Matacchione, Giulia; Perugini, Jessica; Di Mercurio, Eleonora; Sabbatinelli, Jacopo; Prattichizzo, Francesco; Senzacqua, Martina; Storci, Gianluca; Dani, Christian; Lezoche, Giovanni; Guerrieri, Mario; Giordano, Antonio; Bonafe, Massimiliano; Olivieri, Fabiola.
+Institution
+ Matacchione, Giulia. Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Via Tronto 10/A, Ancona, Italy. g.matacchione@pm.univpm.it.
+ Perugini, Jessica. Department of Experimental and Clinical Medicine, Center of Obesity, Universita Politecnica delle Marche, Ancona, Italy.
+ Di Mercurio, Eleonora. Department of Experimental and Clinical Medicine, Center of Obesity, Universita Politecnica delle Marche, Ancona, Italy.
+ Sabbatinelli, Jacopo. Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Via Tronto 10/A, Ancona, Italy.
+ Prattichizzo, Francesco. IRCCS MultiMedica, Milano, Italy.
+ Senzacqua, Martina. Department of Experimental and Clinical Medicine, Center of Obesity, Universita Politecnica delle Marche, Ancona, Italy.
+ Storci, Gianluca. IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
+ Dani, Christian. Inserm, iBV, Faculte de Medecine, Universite Cote d'Azur, CNRS, Nice Cedex, France.
+ Lezoche, Giovanni. Department of General Surgery, Universita Politecnica delle Marche, Ancona, Italy.
+ Guerrieri, Mario. Department of General Surgery, Universita Politecnica delle Marche, Ancona, Italy.
+ Giordano, Antonio. Department of Experimental and Clinical Medicine, Center of Obesity, Universita Politecnica delle Marche, Ancona, Italy.
+ Bonafe, Massimiliano. Department of Experimental, Diagnostic and Specialty Medicine, Universita di Bologna, Bologna, Italy.
+ Olivieri, Fabiola. Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Via Tronto 10/A, Ancona, Italy.
+ Olivieri, Fabiola. Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
+MeSH Subject Headings
+ Animals
+ Humans
+ *Diabetes Mellitus, Type 2
+ Adipose Tissue
+ Macrophages/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ *Insulin Resistance
+ Inflammation/me [Metabolism]
+ Insulin/me [Metabolism]
+ Glucose/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Obesity/co [Complications]
+Keyword Heading
+ Adipose tissue
+ Inflammaging
+ Insulin resistance
+ Macrophage
+ Obesity
+ Senescent cell
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic inflammation. Recent evidence suggests that an increased burden of senescent cells (SCs) in the adipose tissue of obese/diabetic animal models might underlie such pro-inflammatory phenotype. However, the role of macrophages as candidate SCs, their phenotype, the distribution of SCs among fat depots, and clinical relevance are debated. The senescence marker beta-galactosidase and the macrophage marker CD68 were scored in visceral (vWAT) and subcutaneous (scWAT) adipose tissue from obese patients (n=17) undergoing bariatric surgery and control patients (n=4) subjected to cholecystectomy. A correlation was made between the number of SCs and BMI, serum insulin, and the insulin resistance (IR) index HOMA. The monocyte cell line (THP-1) was cultured in vitro in high glucose milieu (60 mM D-glucose) and subsequently co-cultured with human adipocytes (hMADS) to investigate the reciprocal inflammatory activation. In obese patients, a significantly higher number of SCs was observed in vWAT compared to scWAT; about 70% of these cells expressed the macrophage marker CD68; and the number of SCs in vWAT, but not in scWAT, positively correlated with BMI, HOMA-IR, and insulin. THP-1 cultured in vitro in high glucose milieu acquired a senescent-like phenotype (HgSMs), characterized by a polarization toward a mixed M1/M2-like secretory phenotype. Co-culturing HgSMs with hMADS elicited pro-inflammatory cytokine expression in both cell types, and defective insulin signaling in hMADS. In morbid obesity, expansion of visceral adipose depots involves an increased burden of macrophages with senescent-like phenotype that may promote a pro-inflammatory profile and impair insulin signaling in adipocytes, supporting a framework where senescent macrophages fuel obesity-induced systemic inflammation and possibly contribute to the development of IR. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Insulin). IY9XDZ35W2 (Glucose). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs11357-022-00536-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Matacchione&issn=2509-2723&title=GeroScience&atitle=Senescent+macrophages+in+the+human+adipose+tissue+as+a+source+of+inflammaging.&volume=44&issue=4&spage=1941&epage=1960&date=2022&doi=10.1007%2Fs11357-022-00536-0&pmid=35247131&sid=OVID:medline
+
+<556>
+Unique Identifier
+ 35244176
+Title
+ Urinary miRNA Profiles in Chronic Kidney Injury-Benefits of Extracellular Vesicle Enrichment and miRNAs as Potential Biomarkers for Renal Fibrosis, Glomerular Injury, and Endothelial Dysfunction.
+Source
+ Toxicological Sciences. 187(1):35-50, 2022 04 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Petzuch B; Benardeau A; Hofmeister L; Meyer J; Hartmann E; Pavkovic M; Mathar I; Sandner P; Ellinger-Ziegelbauer H
+Author NameID
+ Ellinger-Ziegelbauer, Heidrun; ORCID: https://orcid.org/0000-0003-0247-4210
+Authors Full Name
+ Petzuch, Barbara; Benardeau, Agnes; Hofmeister, Lucas; Meyer, Jutta; Hartmann, Elke; Pavkovic, Mira; Mathar, Ilka; Sandner, Peter; Ellinger-Ziegelbauer, Heidrun.
+Institution
+ Petzuch, Barbara. Investigational Toxicology, Bayer AG, Pharmaceuticals, 42096 Wuppertal, Germany.
+ Petzuch, Barbara. Investigative Toxicology, Department of Non-Clinical Drug Safety, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach (Ris), Germany.
+ Benardeau, Agnes. Cardio-Renal Biology, Novo Nordisk A/S, 2760 Malov, Denmark.
+ Hofmeister, Lucas. Cardiovascular Research, Bayer AG, Pharmaceuticals, 42096 Wuppertal, Germany.
+ Meyer, Jutta. Cardiovascular Research, Bayer AG, Pharmaceuticals, 42096 Wuppertal, Germany.
+ Hartmann, Elke. Toxicology, Pathology and Clinical Pathology, Bayer AG, Pharmaceuticals, 42096 Wuppertal, Germany.
+ Pavkovic, Mira. Investigational Toxicology, Bayer AG, Pharmaceuticals, 42096 Wuppertal, Germany.
+ Mathar, Ilka. Cardiovascular Research, Bayer AG, Pharmaceuticals, 42096 Wuppertal, Germany.
+ Sandner, Peter. Cardiovascular Research, Bayer AG, Pharmaceuticals, 42096 Wuppertal, Germany.
+ Sandner, Peter. Institute of Pharmacology, Hannover Medical School, 30625 Hannover, Germany.
+ Ellinger-Ziegelbauer, Heidrun. Investigational Toxicology, Bayer AG, Pharmaceuticals, 42096 Wuppertal, Germany.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Disease Progression
+ Extracellular Vesicles/me [Metabolism]
+ *Extracellular Vesicles
+ Female
+ Fibrosis
+ Humans
+ Hypertension/me [Metabolism]
+ *Hypertension
+ Kidney/me [Metabolism]
+ Male
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ Obesity/me [Metabolism]
+ Rats
+ *Renal Insufficiency, Chronic
+ Renin/me [Metabolism]
+Keyword Heading
+ biofluid
+ biomarkers
+ miRNAs
+ molecular mechanisms
+ nephrotoxicity
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Micro-RNAs (miRNAs) are regulators of gene expression and play an important role in physiological homeostasis and disease. In biofluids, miRNAs can be found in protein complexes or in extracellular vesicles (EVs). Altered urinary miRNAs are reported as potential biomarkers for chronic kidney disease (CKD). In this context, we compared established urinary protein biomarkers for kidney injury with urinary miRNA profiles in obese ZSF1 and hypertensive renin transgenic rats. Additionally, the benefit of urinary EV enrichment was investigated in vivo and the potential association of urinary miRNAs with renal fibrosis in vitro. Kidney damage in both rat models was confirmed by histopathology, proteinuria, and increased levels of urinary protein biomarkers. In total, 290 miRNAs were elevated in obese ZSF1 rats compared with lean controls, whereas 38 miRNAs were altered in obese ZSF1 rats during 14-26 weeks of age. These 38 miRNAs correlated better with disease progression than established urinary protein biomarkers. MiRNAs increased in obese ZSF1 rats were associated with renal inflammation, fibrosis, and glomerular injury. Eight miRNAs were also changed in urinary EVs of renin transgenic rats, including one which might play a role in endothelial dysfunction. EV enrichment increased the number and detection level of several miRNAs implicated in renal fibrosis in vitro and in vivo. Our results show the benefit of EV enrichment for miRNA detection and the potential of total urine and urinary EV-associated miRNAs as biomarkers of altered kidney physiology, renal fibrosis and glomerular injury, and disease progression in hypertension and obesity-induced CKD. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs). EC 3-4-23-15 (Renin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1093%2ftoxsci%2fkfac028
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Petzuch&issn=1096-0929&title=Toxicological+Sciences&atitle=Urinary+miRNA+Profiles+in+Chronic+Kidney+Injury-Benefits+of+Extracellular+Vesicle+Enrichment+and+miRNAs+as+Potential+Biomarkers+for+Renal+Fibrosis%2C+Glomerular+Injury%2C+and+Endothelial+Dysfunction.&volume=187&issue=1&spage=35&epage=50&date=2022&doi=10.1093%2Ftoxsci%2Fkfac028&pmid=35244176&sid=OVID:medline
+
+<557>
+Unique Identifier
+ 35240786
+Title
+ Integrative system biology and mathematical modeling of genetic networks identifies shared biomarkers for obesity and diabetes.
+Source
+ Mathematical Biosciences & Engineering: MBE. 19(3):2310-2329, 2022 01 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bima AIH; Elsamanoudy AZ; Albaqami WF; Khan Z; Parambath SV; Al-Rayes N; Kaipa PR; Elango R; Banaganapalli B; Shaik NA
+Authors Full Name
+ Bima, Abdulhadi Ibrahim H; Elsamanoudy, Ayman Zaky; Albaqami, Walaa F; Khan, Zeenath; Parambath, Snijesh Valiya; Al-Rayes, Nuha; Kaipa, Prabhakar Rao; Elango, Ramu; Banaganapalli, Babajan; Shaik, Noor A.
+Institution
+ Bima, Abdulhadi Ibrahim H. Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Elsamanoudy, Ayman Zaky. Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Elsamanoudy, Ayman Zaky. Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
+ Albaqami, Walaa F. Department of Science, Prince Sultan Military College of Health Sciences, Dhahran, Saudi Arabia.
+ Khan, Zeenath. Department of Science, Prince Sultan Military College of Health Sciences, Dhahran, Saudi Arabia.
+ Parambath, Snijesh Valiya. Division of Molecular Medicine, St. John's Research Institute, Bangalore, Karnataka, India.
+ Al-Rayes, Nuha. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Al-Rayes, Nuha. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Kaipa, Prabhakar Rao. Department of Genetics, College of Science, Osmania University, Hyderabad, India.
+ Elango, Ramu. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Elango, Ramu. Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Banaganapalli, Babajan. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Banaganapalli, Babajan. Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Shaik, Noor A. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Shaik, Noor A. Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Computational Biology/mt [Methods]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Diabetes Mellitus, Type 2
+ Gene Expression Profiling
+ *Gene Regulatory Networks
+ Humans
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Protein Interaction Maps
+Keyword Heading
+ DEGs
+ PPI
+ diabetes mellitus
+ gene network
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and type 2 and diabetes mellitus (T2D) are two dual epidemics whose shared genetic pathological mechanisms are still far from being fully understood. Therefore, this study is aimed at discovering key genes, molecular mechanisms, and new drug targets for obesity and T2D by analyzing the genome wide gene expression data with different computational biology approaches. In this study, the RNA-sequencing data of isolated primary human adipocytes from individuals who are lean, obese, and T2D was analyzed by an integrated framework consisting of gene expression, protein interaction network (PIN), tissue specificity, and druggability approaches. Our findings show a total of 1932 unique differentially expressed genes (DEGs) across the diabetes versus obese group comparison (p<=0.05). The PIN analysis of these 1932 DEGs identified 190 high centrality network (HCN) genes, which were annotated against 3367 GO terms and functional pathways, like response to insulin signaling, phosphorylation, lipid metabolism, glucose metabolism, etc. (p<=0.05). By applying additional PIN and topological parameters to 190 HCN genes, we further mapped 25 high confidence genes, functionally connected with diabetes and obesity traits. Interestingly, ERBB2, FN1, FYN, HSPA1A, HBA1, and ITGB1 genes were found to be tractable by small chemicals, antibodies, and/or enzyme molecules. In conclusion, our study highlights the potential of computational biology methods in correlating expression data to topological parameters, functional relationships, and druggability characteristics of the candidate genes involved in complex metabolic disorders with a common etiological basis.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3934%2fmbe.2022107
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bima&issn=1547-1063&title=Mathematical+Biosciences+%26+Engineering%3A+MBE&atitle=Integrative+system+biology+and+mathematical+modeling+of+genetic+networks+identifies+shared+biomarkers+for+obesity+and+diabetes.&volume=19&issue=3&spage=2310&epage=2329&date=2022&doi=10.3934%2Fmbe.2022107&pmid=35240786&sid=OVID:medline
+
+<558>
+Unique Identifier
+ 35240580
+Title
+ The Protective Role of Physical Fitness on Cardiometabolic Risk During Pregnancy: The GESTAtion and FITness Project.
+Source
+ International Journal of Sport Nutrition & Exercise Metabolism. 32(3):163-176, 2022 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Acosta-Manzano P; Acosta FM; Flor-Alemany M; Gavilan-Carrera B; Delgado-Fernandez M; Baena-Garcia L; Segura-Jimenez V; Aparicio VA
+Author NameID
+ Acosta-Manzano, Pedro; ORCID: https://orcid.org/0000-0002-4494-2353
+Authors Full Name
+ Acosta-Manzano, Pedro; Acosta, Francisco M; Flor-Alemany, Marta; Gavilan-Carrera, Blanca; Delgado-Fernandez, Manuel; Baena-Garcia, Laura; Segura-Jimenez, Victor; Aparicio, Virginia A.
+Institution
+ Acosta-Manzano, Pedro. PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research Group, Department of Physical Education and Sports, Faculty of Sports Science, University of Granada, Granada,Spain.
+ Acosta-Manzano, Pedro. Sport and Health University Research Institute (iMUDS), University of Granada, Granada,Spain.
+ Acosta-Manzano, Pedro. Institute of Human Movement Science, Sport and Health, University of Graz, Austria.
+ Acosta, Francisco M. Sport and Health University Research Institute (iMUDS), University of Granada, Granada,Spain.
+ Acosta, Francisco M. PROFITH "PROmoting FITness and Health through physical activity" Research Group, Department of Physical Education and Sports, Faculty of Sports Science, University of Granada, Granada,Spain.
+ Acosta, Francisco M. Turku PET Centre, University of Turku, Turku,Finland.
+ Acosta, Francisco M. Turku PET Centre, Turku University Hospital, Turku,Finland.
+ Flor-Alemany, Marta. Sport and Health University Research Institute (iMUDS), University of Granada, Granada,Spain.
+ Flor-Alemany, Marta. Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology (INYTA), University of Granada, Granada,Spain.
+ Gavilan-Carrera, Blanca. PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research Group, Department of Physical Education and Sports, Faculty of Sports Science, University of Granada, Granada,Spain.
+ Gavilan-Carrera, Blanca. Sport and Health University Research Institute (iMUDS), University of Granada, Granada,Spain.
+ Delgado-Fernandez, Manuel. PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research Group, Department of Physical Education and Sports, Faculty of Sports Science, University of Granada, Granada,Spain.
+ Delgado-Fernandez, Manuel. Sport and Health University Research Institute (iMUDS), University of Granada, Granada,Spain.
+ Baena-Garcia, Laura. Sport and Health University Research Institute (iMUDS), University of Granada, Granada,Spain.
+ Baena-Garcia, Laura. Department of Nursing, Faculty of Health Sciences, University of Granada, Granada,Spain.
+ Segura-Jimenez, Victor. Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Spain.
+ Segura-Jimenez, Victor. Biomedical Research and Innovation Institute of Cadiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cadiz,Spain.
+ Segura-Jimenez, Victor. Hospital Universitario Virgen de las Nieves, Granada,Spain.
+ Segura-Jimenez, Victor. Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada,Spain.
+ Aparicio, Virginia A. Sport and Health University Research Institute (iMUDS), University of Granada, Granada,Spain.
+ Aparicio, Virginia A. Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology (INYTA), University of Granada, Granada,Spain.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ Cardiorespiratory Fitness/ph [Physiology]
+ *Cardiorespiratory Fitness
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Female
+ Humans
+ *Insulin Resistance
+ Obesity
+ Overweight
+ Physical Fitness/ph [Physiology]
+ Pregnancy
+ Risk Factors
+Keyword Heading
+ aerobic
+ cardiorespiratory
+ lifestyle
+ strength
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Physical fitness (PF) is a cornerstone of metabolic health. However, its role in maternal-fetal metabolism during pregnancy is poorly understood. The present work investigates: (i) the association of PF with maternal and fetal cardiometabolic markers, and with clustered cardiometabolic risk during pregnancy, and (ii) whether being fit counteracts cardiometabolic abnormalities associated with overweight/obesity. Several PF components (flexibility, lower and upper body strength, and cardiorespiratory fitness [CRF]) were objectively assessed in 151 pregnant women at gestational weeks 16 and 33, and an overall PF cluster score calculated. At the same times, maternal glycemic and lipid markers, cortisol, and C-reactive protein were assessed with standard biochemical methods, along with blood pressure and a proxy for insulin resistance, and a cardiometabolic risk cluster score determined. These analytes were also measured in maternal and umbilical cord arterial and venous blood collected at delivery. PF was found to be associated with several maternal and a small number of fetal cardiometabolic markers (p < .05). Lower and upper body muscle strength, CRF, overall PF (week 16), and CRF changes (weeks 16-33) were inversely associated with clustered cardiometabolic risk (p < .05). Normal weight fit women had lower values for insulin level, insulin resistance, triglycerides, low-density lipoprotein cholesterol, C-reactive protein, and diastolic blood pressure than did overweight/obese unfit women at week 16 (p < .05). In conclusion, greater PF, especially muscle strength and CRF in early-middle pregnancy, appears to be associated with a better metabolic phenotype, and may protect against maternal cardiometabolic risk. "Keep yourself fit and normal weight before and during early pregnancy" should be a key public health message.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1123%2fijsnem.2021-0274
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Acosta-Manzano&issn=1526-484X&title=International+Journal+of+Sport+Nutrition+%26+Exercise+Metabolism&atitle=The+Protective+Role+of+Physical+Fitness+on+Cardiometabolic+Risk+During+Pregnancy%3A+The+GESTAtion+and+FITness+Project.&volume=32&issue=3&spage=163&epage=176&date=2022&doi=10.1123%2Fijsnem.2021-0274&pmid=35240580&sid=OVID:medline
+
+<559>
+Unique Identifier
+ 35220416
+Title
+ Does inflammation mediate the association between obesity and hearing status in mid-childhood and mid-life?.
+Source
+ International Journal of Obesity. 46(6):1188-1195, 2022 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang J; Liu M; Sung V; Grobler A; Saffery R; Lange K; Burgner D; Wake M
+Author NameID
+ Wang, Jing; ORCID: http://orcid.org/0000-0001-5701-476X
+ Liu, Mengjiao; ORCID: http://orcid.org/0000-0002-8337-7633
+ Saffery, Richard; ORCID: http://orcid.org/0000-0002-9510-4181
+ Lange, Katherine; ORCID: http://orcid.org/0000-0002-8175-6285
+ Burgner, David; ORCID: http://orcid.org/0000-0002-8304-4302
+ Wake, Melissa; ORCID: http://orcid.org/0000-0001-7501-9257
+Authors Full Name
+ Wang, Jing; Liu, Mengjiao; Sung, Valerie; Grobler, Anneke; Saffery, Richard; Lange, Katherine; Burgner, David; Wake, Melissa.
+Institution
+ Wang, Jing. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
+ Wang, Jing. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Liu, Mengjiao. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
+ Liu, Mengjiao. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Liu, Mengjiao. School of Public Health, Nanchang University, Nanchang, Jiangxi, China.
+ Liu, Mengjiao. Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Nanchang, Jiangxi, China.
+ Sung, Valerie. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
+ Sung, Valerie. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Sung, Valerie. Department of General Medicine, Royal Children's Hospital, Parkville, VIC, Australia.
+ Grobler, Anneke. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
+ Grobler, Anneke. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Saffery, Richard. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
+ Saffery, Richard. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Lange, Katherine. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
+ Lange, Katherine. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Burgner, David. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
+ Burgner, David. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Burgner, David. School of Public Health, Nanchang University, Nanchang, Jiangxi, China.
+ Burgner, David. Department of Paediatrics, Monash University, Clayton, VIC, Australia.
+ Wake, Melissa. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia. melissa.wake@mcri.edu.au.
+ Wake, Melissa. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia. melissa.wake@mcri.edu.au.
+ Wake, Melissa. Liggins Institute, University of Auckland, Grafton, Auckland, New Zealand. melissa.wake@mcri.edu.au.
+MeSH Subject Headings
+ Australia/ep [Epidemiology]
+ Biomarkers
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Child
+ Cross-Sectional Studies
+ Glycoproteins
+ Hearing
+ Hearing Loss/ep [Epidemiology]
+ Hearing Loss/et [Etiology]
+ *Hearing Loss
+ Humans
+ Inflammation
+ Longitudinal Studies
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+Abstract
+ BACKGROUND: Obesity is characterized by heightened inflammation, and both phenotypes are associated with hearing loss. We aimed to determine if inflammation mediates the associations between obesity and hearing ability in mid-childhood and mid-life.
+
+ METHODS: Participants: 1165 11- to 12-year-old children and 1316 parents in the population-based cross-sectional Child Health CheckPoint within the Longitudinal Study of Australian Children. Adiposity measures: Body mass index (BMI) classified as normal, overweight and obesity; waist-to-height ratio (WHtR) classified as <0.5 and >=0.5; fat mass index. Inflammatory biomarkers: Serum glycoprotein A (GlycA); high-sensitivity C-reactive protein (hsCRP). Audiometry: Composite high Fletcher Index (mean threshold of 1, 2, 4 kHz) in the better ear.
+
+ ANALYSIS: Causal mediation analysis decomposed a 'total effect' (obesity on hearing status) into 'indirect' effect via a mediator (eg GlycA, hsCRP) and 'direct' effect via other pathways, adjusting for age, sex and socioeconomic position.
+
+ RESULTS: Compared to adults with BMI within the normal range, those with obesity had hearing thresholds 1.9 dB HL (95% CI 1.0-2.8) higher on the high Fletcher Index; 40% of the total effect was mediated via GlycA (indirect effect: 0.8 dB HL, 95% CI 0.1-1.4). Children with obesity had hearing thresholds 1.3 dB HL (95% CI 0.2-2.5) higher than those with normal BMI, of which 67% (indirect effect: 0.9 dB HL, 95% CI 0.4-1.4) was mediated via GlycA. Similar mediation effects were noted using other adiposity measures. Similar but less marked mediation effects were observed when hsCRP was used as the inflammatory biomarker (6-23% in adults and 23-33% in children).
+
+ CONCLUSIONS: Inflammation may play an important mediating role in the modest hearing reductions associated with obesity, particularly in children. These findings offer insights into possible mechanisms and early prevention strategies for hearing loss. Copyright © 2022. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycoproteins). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41366-022-01080-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Does+inflammation+mediate+the+association+between+obesity+and+hearing+status+in+mid-childhood+and+mid-life%3F.&volume=46&issue=6&spage=1188&epage=1195&date=2022&doi=10.1038%2Fs41366-022-01080-9&pmid=35220416&sid=OVID:medline
+
+<560>
+Unique Identifier
+ 35206286
+Title
+ Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients-The Debate Is Still Open. [Review]
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 19(4), 2022 02 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kruszewska J; Laudy-Wiaderny H; Kunicki M
+Author NameID
+ Kruszewska, Jagoda; ORCID: https://orcid.org/0000-0002-7609-8935
+ Laudy-Wiaderny, Hanna; ORCID: https://orcid.org/0000-0001-8573-764X
+Authors Full Name
+ Kruszewska, Jagoda; Laudy-Wiaderny, Hanna; Kunicki, Michal.
+Institution
+ Kruszewska, Jagoda. Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-097 Warsaw, Poland.
+ Laudy-Wiaderny, Hanna. Independent Public Healthcare Complex in Masovian Minsk, 05-300 Masovian Minsk, Poland.
+ Kunicki, Michal. Department of Gynecological Endocrinology, Medical University of Warsaw, 00-315 Warsaw, Poland.
+ Kunicki, Michal. INVICTA Fertility and Reproductive Center, 00-019 Warsaw, Poland.
+MeSH Subject Headings
+ Biomarkers
+ Fasting
+ Female
+ Humans
+ Insulin Resistance/ph [Physiology]
+ *Insulin Resistance
+ Obesity/co [Complications]
+ Polycystic Ovary Syndrome/co [Complications]
+ *Polycystic Ovary Syndrome
+Keyword Heading
+ galectin
+ gremlin
+ insulin resistance
+ myonectin
+ nesfatin
+ neuregulin
+ omentin
+ polycystic ovarian syndrome
+ preptin
+ xenin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Research on proteins and peptides that play roles in metabolic regulation, which may be considered potential insulin resistance markers in some medical conditions, such as diabetes mellitus, obesity and polycystic ovarian syndrome (PCOS), has recently gained in interest. PCOS is a common endocrine disorder associated with hyperandrogenemia and failure of ovulation, which is often accompanied by metabolic abnormalities, including obesity, dyslipidemia, hyperinsulinemia, and insulin resistance. In this review, we focus on less commonly known peptides/proteins and investigate their role as potential biomarkers for insulin resistance in females affected by PCOS. We summarize studies comparing the serum fasting concentration of particular agents in PCOS individuals and healthy controls. Based on our analysis, we propose that, in the majority of studies, the levels of nesfastin-1, myonectin, omentin, neudesin were decreased in PCOS patients, while the levels of the other considered agents (e.g., preptin, gremlin-1, neuregulin-4, xenopsin-related peptide, xenin-25, and galectin-3) were increased. However, there also exist studies presenting contrary results; in particular, most data existing for lipocalin-2 are inconsistent. Therefore, further research is required to confirm those hypotheses, as well as to elucidate the involvement of these factors in PCOS-related metabolic complications.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fijerph19042099
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kruszewska&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Review+of+Novel+Potential+Insulin+Resistance+Biomarkers+in+PCOS+Patients-The+Debate+Is+Still+Open.&volume=19&issue=4&spage=&epage=&date=2022&doi=10.3390%2Fijerph19042099&pmid=35206286&sid=OVID:medline
+
+<561>
+Unique Identifier
+ 35189898
+Title
+ The healthy/unhealthy dietary pattern is associated with resting metabolic rate status among women with overweight/obesity.
+Source
+ BMC Endocrine Disorders. 22(1):45, 2022 Feb 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pooyan S; Mirzababaei A; Sajjadi SF; Badrooj N; Nasir Y; Tajik S; Fallahyekta M; Yekaninezhad MS; Mirzaei K
+Authors Full Name
+ Pooyan, Sara; Mirzababaei, Atieh; Sajjadi, Seyedeh Forough; Badrooj, Negin; Nasir, Yasaman; Tajik, Somayeh; Fallahyekta, Masoumeh; Yekaninezhad, Mir Saeid; Mirzaei, Khadijeh.
+Institution
+ Pooyan, Sara. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
+ Mirzababaei, Atieh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
+ Sajjadi, Seyedeh Forough. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
+ Badrooj, Negin. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
+ Nasir, Yasaman. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
+ Tajik, Somayeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
+ Fallahyekta, Masoumeh. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
+ Yekaninezhad, Mir Saeid. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran. mirzaei_kh@sina.tums.ac.ir.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Anthropometry
+ *Basal Metabolism
+ Biomarkers/bl [Blood]
+ Calorimetry, Indirect
+ Cross-Sectional Studies
+ Diet, Healthy
+ *Eating
+ Female
+ Humans
+ Middle Aged
+ *Obesity/me [Metabolism]
+ *Overweight/me [Metabolism]
+Keyword Heading
+ Deviation of normal RMR
+ Dietary pattern
+ Obesity
+ Resting metabolic rate
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although various dietary patterns have been indicated to be associated with the resting metabolic rate [RMR], limited data are available in this field. This study was therefore focused on the association between dietary patterns and resting metabolic rate among participants with overweight and obesity.
+
+ METHODS: This cross-sectional study was conducted on 304 women with overweight or obesity (BMI >= 25 kg/m2), aged 18-50. Anthropometric assessments, physical activity and biochemical measurements were assessed. RMR was also measured by means of indirect calorimetry. Dietary intake of participants was evaluated by 147-item semi-quantitative food frequency questionnaire [FFQ].
+
+ RESULTS: There was a significant association between higher adherence to the healthy dietary pattern [HDP] and RMR (P = 0.05), intakes of protein (P = 0.003), minerals (P = 0.001) as well as fat free mass [FFM] (P = 0.002), bone mineral content (P = 0.001), skeletal muscle mass (P = 0.001), soft lean mass (P = 0.002) and visceral fat area (P = 0.05). Also, there was a considerable association between higher adherence to the unhealthy dietary pattern [UHDP] and fasting blood sugar [FBS] (P = 0.05). Using multinomial logistic regression has been shown that the medium adherence to the HDP was marginally significant with decreased resting metabolic rate [Dec. RMR] group in crude model (OR: 0.54; 95% CI: 0.28-1.05, P = 0.07). After controlling for various confounders such as age, FFM, physical activity, and energy intake, the association between Dec. RMR group and the lowest quartile of the HDP (OR: 0.36; 95% CI: 0.14-0.91, P = 0.03) became significant as well as the association between Dec. RMR group and medium adherence to the HDP (OR: 0.42; 95% CI: 0.18-0.97, P = 0.04). The medium adherence to the UHDP in crude model was also significant with increased resting metabolic rate [Inc. RMR] group (OR: 2.59; 95% CI: 1.01-6.65, P = 0.04).
+
+ CONCLUSIONS: Our study showed that there are significant associations between dietary patterns and RMR status. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1186%2fs12902-022-00958-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pooyan&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=The+healthy%2Funhealthy+dietary+pattern+is+associated+with+resting+metabolic+rate+status+among+women+with+overweight%2Fobesity.&volume=22&issue=1&spage=45&epage=&date=2022&doi=10.1186%2Fs12902-022-00958-z&pmid=35189898&sid=OVID:medline
+
+<562>
+Unique Identifier
+ 35183472
+Title
+ Siolmatra brasiliensis stem extract ameliorates antioxidant defenses and mitigates glycoxidative stress in mice with high-fat diet-induced obesity.
+Source
+ Obesity Research & Clinical Practice. 16(2):130-137, 2022 Mar-Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Talpo TC; Motta BP; Oliveira JO; Figueiredo ID; Pinheiro CG; Dos Santos CHC; Carvalho MG; Brunetti IL; Baviera AM
+Authors Full Name
+ Talpo, Tassiana Cristina; Motta, Bruno Pereira; Oliveira, Juliana Oriel de; Figueiredo, Ingrid Delbone; Pinheiro, Camila Graca; Dos Santos, Carlos Henrique Correa; Carvalho, Mario Geraldo de; Brunetti, Iguatemy Lourenco; Baviera, Amanda Martins.
+Institution
+ Talpo, Tassiana Cristina. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Motta, Bruno Pereira. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Oliveira, Juliana Oriel de. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Figueiredo, Ingrid Delbone. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Pinheiro, Camila Graca. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Dos Santos, Carlos Henrique Correa. Federal Rural University of Rio de Janeiro (UFRRJ), Institute of Exact Sciences, Department of Chemistry, Seropedica, Rio de Janeiro, Brazil.
+ Carvalho, Mario Geraldo de. Federal Rural University of Rio de Janeiro (UFRRJ), Institute of Exact Sciences, Department of Chemistry, Seropedica, Rio de Janeiro, Brazil.
+ Brunetti, Iguatemy Lourenco. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Baviera, Amanda Martins. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil. Electronic address: amanda.baviera@unesp.br.
+MeSH Subject Headings
+ Animals
+ Antioxidants/pd [Pharmacology]
+ Aryldialkylphosphatase
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat
+ Glucose/me [Metabolism]
+ Glucose Intolerance/dt [Drug Therapy]
+ Glucose Intolerance/me [Metabolism]
+ *Glucose Intolerance
+ Humans
+ *Insulin Resistance
+ Lipid Peroxidation
+ Liver/me [Metabolism]
+ Mice
+ Mice, Inbred C57BL
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Oxidative Stress
+ Plant Extracts/pd [Pharmacology]
+ Superoxide Dismutase/me [Metabolism]
+ Superoxide Dismutase/pd [Pharmacology]
+ Thiobarbituric Acid Reactive Substances/me [Metabolism]
+ Thiobarbituric Acid Reactive Substances/pd [Pharmacology]
+Keyword Heading
+ Advanced glycation end products
+ Antioxidant defenses
+ Cucurbitaceae
+ Lipid peroxidation
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is accompanied by insulin resistance and glucose intolerance, which favor the onset of complications related to oxidative stress. The aim of this study was to investigate the effects and underlying mechanisms of hydroethanolic extract from Siolmatra brasiliensis stems on insulin resistance, glucose intolerance, advanced glycation end product (AGE) formation, and oxidative stress in mice with induced obesity.
+
+ METHODS: C57BL-6 J mice were fed a high-fat diet for 14 weeks and treated with 125 or 250 mg/kg S. brasiliensis extract during the last 7 weeks. The study assessed glucose tolerance and insulin sensitivity, lipid profile, plasma levels of thiobarbituric acid reactive substances (TBARS, biomarkers of oxidative damage), fluorescent AGEs (biomarkers of advanced glycation), and paraoxonase 1 (PON1) activity (antioxidant enzyme). The activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the liver and kidneys were also investigated.
+
+ RESULTS: Siolmatra brasiliensis extract had antiobesogenic effects; improved insulin sensitivity and glucose tolerance; decreased the total plasma cholesterol levels; decreased the levels of glycoxidative stress biomarkers, including AGEs (plasma, liver, kidneys) and TBARS (liver, kidneys); and also improved endogenous antioxidant defenses by increasing the activities of PON1 (plasma), SOD (kidneys), CAT (liver, kidneys), and GSH-Px (kidneys).
+
+ CONCLUSION: This study expands on our knowledge about the pharmacological properties of S. brasiliensis and substantiates the potential of this plant species to be used as a complementary therapeutic agent to alleviate the metabolic dysfunctions resulting from dyslipidemia and glycoxidative stress. Copyright © 2022 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Plant Extracts). 0 (Thiobarbituric Acid Reactive Substances). EC 1-15-1-1 (Superoxide Dismutase). EC 3-1-8-1 (Aryldialkylphosphatase). EC 3-1-8-1 (PON1 protein, human). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.orcp.2022.02.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Talpo&issn=1871-403X&title=Obesity+Research+%26+Clinical+Practice&atitle=Siolmatra+brasiliensis+stem+extract+ameliorates+antioxidant+defenses+and+mitigates+glycoxidative+stress+in+mice+with+high-fat+diet-induced+obesity.&volume=16&issue=2&spage=130&epage=137&date=2022&doi=10.1016%2Fj.orcp.2022.02.004&pmid=35183472&sid=OVID:medline
+
+<563>
+Unique Identifier
+ 35177705
+Title
+ Circulating acyl and des-acyl ghrelin levels in obese adults: a systematic review and meta-analysis.
+Source
+ Scientific Reports. 12(1):2679, 2022 02 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang Y; Wu Q; Zhou Q; Chen Y; Lei X; Chen Y; Chen Q
+Authors Full Name
+ Wang, Yanmei; Wu, Qianxian; Zhou, Qian; Chen, Yuyu; Lei, Xingxing; Chen, Yiding; Chen, Qiu.
+Institution
+ Wang, Yanmei. Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Jinniu District, Chengdu, 610075, Sichuan, China.
+ Wang, Yanmei. Ya'an Polytechnic College, No. 130 Yucai Road, Yucheng District, Yaan, 625000, Sichuan, China.
+ Wu, Qianxian. Ya'an Polytechnic College, No. 130 Yucai Road, Yucheng District, Yaan, 625000, Sichuan, China.
+ Zhou, Qian. Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Jinniu District, Chengdu, 610075, Sichuan, China.
+ Chen, Yuyu. Halifa Regional Centre for Education, No. 33 Spectacle Lake Dr, Dartmouth, NS, B3B1X7, Canada.
+ Lei, Xingxing. Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Jinniu District, Chengdu, 610075, Sichuan, China.
+ Chen, Yiding. Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Jinniu District, Chengdu, 610075, Sichuan, China.
+ Chen, Qiu. Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Jinniu District, Chengdu, 610075, Sichuan, China. chenqiu1005@cdutcm.edu.cn.
+MeSH Subject Headings
+ Acylation
+ Adult
+ Biomarkers/bl [Blood]
+ *Ghrelin/aa [Analogs & Derivatives]
+ Ghrelin/bl [Blood]
+ Humans
+ *Obesity/bl [Blood]
+Abstract
+ Ghrelin is the only known orexigenic gut hormone, and its synthesis, secretion and degradation are affected by different metabolic statuses. This meta-analysis aimed to investigate the potential differences in plasma acyl ghrelin (AG) and des-acyl ghrelin (DAG) concentrations between normal weight and obese adults. Systematic literature searches of PubMed, Embase and Web of Science through October 2021 were conducted for articles reporting AG or DAG levels in obesity and normal weight, and 34 studies with 1863 participants who met the eligibility criteria were identified. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated to evaluate group differences in circulating AG and DAG levels. Pooled effect size showed significantly lower levels of baseline AG (SMD: - 0.85; 95% CI: - 1.13 to - 0.57; PSMD < 0.001) and DAG (SMD: - 1.06; 95% CI: - 1.43 to - 0.69; PSMD < 0.001) in obese groups compared with healthy controls, and similar results were observed when subgroup analyses were stratified by the assay technique or storage procedure. Postprandial AG levels in obese subjects were significantly lower than those in controls when stratified by different time points (SMD 30 min: - 0.85, 95% CI: - 1.18 to - 0.53, PSMD < 0.001; SMD 60 min: - 1.00, 95% CI: - 1.37 to - 0.63, PSMD < 0.001; SMD 120 min: - 1.21, 95% CI: - 1.59 to - 0.83, PSMD < 0.001). In healthy subjects, a postprandial decline in AG was observed at 120 min (SMD: - 0.42; 95% CI: - 0.77 to - 0.06; PSMD = 0.021) but not in obese subjects (SMD: - 0.28; 95% CI: - 0.60 to 0.03; PSMD = 0.074). The mean change in AG concentration was similar in both the obese and lean health groups at each time point (DELTASMD30min: 0.31, 95% CI: - 0.35 to 0.97, PSMD = 0.359; DELTASMD60min: 0.17, 95% CI: - 0.12 to 0.46, PSMD = 0.246; DELTASMD120min: 0.21, 95% CI: - 0.13 to 0.54, PSMD = 0.224). This meta-analysis strengthens the clinical evidence supporting the following: lower baseline levels of circulating AG and DAG in obese individuals; declines in postprandial circulating AG levels, both for the healthy and obese individuals; a shorter duration of AG suppression in obese subjects after meal intake. These conclusions have significance for follow-up studies to elucidate the role of various ghrelin forms in energy homeostasis. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ghrelin). 0 (acyl-ghrelin). 0 (ghrelin, des-n-octanoyl).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41598-022-06636-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=2045-2322&title=Scientific+Reports&atitle=Circulating+acyl+and+des-acyl+ghrelin+levels+in+obese+adults%3A+a+systematic+review+and+meta-analysis.&volume=12&issue=1&spage=2679&epage=&date=2022&doi=10.1038%2Fs41598-022-06636-3&pmid=35177705&sid=OVID:medline
+
+<564>
+Unique Identifier
+ 35159232
+Title
+ Cardiovascular Biomarker Profiles in Obesity and Relation to Normalization of Subclinical Cardiac Dysfunction after Bariatric Surgery.
+Source
+ Cells. 11(3), 2022 01 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Snelder SM; Pouw N; Aga Y; Castro Cabezas M; Biter LU; Zijlstra F; Kardys I; van Dalen BM
+Authors Full Name
+ Snelder, Sanne M; Pouw, Nadine; Aga, Yaar; Castro Cabezas, Manuel; Biter, L Ulas; Zijlstra, Felix; Kardys, Isabella; van Dalen, Bas M.
+Institution
+ Snelder, Sanne M. Department of Cardiology, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
+ Pouw, Nadine. Department of Clinical Chemistry, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
+ Aga, Yaar. Department of Cardiology, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
+ Castro Cabezas, Manuel. Department of Internal Medicine, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
+ Biter, L Ulas. Department of Surgery, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
+ Zijlstra, Felix. Department of Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
+ Kardys, Isabella. Department of Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
+ van Dalen, Bas M. Department of Cardiology, Franciscus Gasthuis & Vlietland, 3045 PM Rotterdam, The Netherlands.
+ van Dalen, Bas M. Department of Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
+MeSH Subject Headings
+ *Atherosclerosis
+ *Bariatric Surgery
+ Biomarkers
+ *Heart Diseases
+ Humans
+ Inflammation
+ *Insulin Resistance
+ Longitudinal Studies
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+Keyword Heading
+ bariatric surgery
+ biomarkers
+ cardiac dysfunction
+ obesity/obese
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: We aimed to gain insight into the underlying pathophysiology of cardiac dysfunction in obesity patients and the improvement of cardiac function after weight loss.
+
+ METHODS: This is a longitudinal study in which 92 cardiovascular biomarkers were measured by multiplex immunoassays in obesity patients without known cardiovascular disease, before and one year after bariatric surgery.
+
+ RESULTS: Out of 100 eligible patients, 72 patients completed the follow-up. A total of 72 (78%) biomarkers changed significantly. The biomarkers with the highest relative changes represented processes linked mainly to insulin resistance and inflammation. In the patients with persistent subclinical cardiac dysfunction, the baseline values of 10 biomarkers were different from values in patients with normalization of cardiac function. Most of these biomarkers were linked to inflammation or atherosclerosis. Finally, a model was developed to investigate the relationship between changes in the biomarkers and persistent subclinical cardiac dysfunction. Seven biomarkers were retained in this model, mainly linked to inflammation, atherosclerosis, and hypercoagulability.
+
+ CONCLUSION: The majority (78%) of cardiovascular biomarkers changed, pointing mainly to modulation of insulin resistance and inflammation. The baseline levels of 10 biomarkers, as well as pre- to post-bariatric surgery changes in seven biomarkers, were related to persistent subclinical cardiac dysfunction after bariatric surgery.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fcells11030422
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Snelder&issn=2073-4409&title=Cells&atitle=Cardiovascular+Biomarker+Profiles+in+Obesity+and+Relation+to+Normalization+of+Subclinical+Cardiac+Dysfunction+after+Bariatric+Surgery.&volume=11&issue=3&spage=&epage=&date=2022&doi=10.3390%2Fcells11030422&pmid=35159232&sid=OVID:medline
+
+<565>
+Unique Identifier
+ 35152861
+Title
+ Long Non-Coding RNAs and Obesity: New Potential Pathogenic Biomarkers. [Review]
+Source
+ Current Pharmaceutical Design. 28(19):1592-1605, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fontanini M; Cabiati M; Giacomarra M; Federico G; Del Ry S
+Authors Full Name
+ Fontanini, Martina; Cabiati, Manuela; Giacomarra, Manuel; Federico, Giovanni; Del Ry, Silvia.
+Institution
+ Fontanini, Martina. CNR Institute of Clinical Physiology, Biochemistry and Molecular Biology laboratory, Via G. Moruzzi 1, 56124 Pisa Italy.
+ Cabiati, Manuela. CNR Institute of Clinical Physiology, Biochemistry and Molecular Biology laboratory, Via G. Moruzzi 1, 56124 Pisa Italy.
+ Giacomarra, Manuel. CNR Institute of Clinical Physiology, Biochemistry and Molecular Biology laboratory, Via G. Moruzzi 1, 56124 Pisa Italy.
+ Federico, Giovanni. Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Via Roma n. 67 56126 Pisa, Italy.
+ Del Ry, Silvia. CNR Institute of Clinical Physiology, Biochemistry and Molecular Biology laboratory, Via G. Moruzzi 1, 56124 Pisa Italy.
+MeSH Subject Headings
+ Adipogenesis/ge [Genetics]
+ Biomarkers/me [Metabolism]
+ Humans
+ Lipid Metabolism
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ RNA, Long Noncoding/ge [Genetics]
+ RNA, Long Noncoding/me [Metabolism]
+ *RNA, Long Noncoding
+Keyword Heading
+ Long non-coding RNA (lncRNAs)
+ adipogenesis
+ biomarkers
+ lipid metabolism
+ lipogenesis
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: A portion of the human genome is characterized by long non-coding RNAs (lncRNAs), a class of non-coding RNA longer than 200 nucleotides. Recently, the development of new biomolecular methods made it possible to delineate the involvement of lncRNAs in the regulation of different biological processes, both physiological and pathological, by acting within the cell with different regulatory mechanisms based on their specific target. To date, obesity is one of the most important health problems spreading all over the world, including the children: the search for new potential early biomarkers could open the doors to novel therapeutic strategies useful to fight the disease early in life and to reduce the risk of obesity-related co-morbidities.
+
+ OBJECTIVE: This review highlights the lncRNAs involved in obesity, in adipogenesis, and lipid metabolism, particularly in lipogenesis.
+
+ CONCLUSION: LncRNAs involved in adipogenesis and lipogenesis, being at the cross-road of obesity, should be deeply analysed in this contest, allowing to understand possible causative actions in starting obesity and whether they might be helpful to treat obesity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Long Noncoding).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.2174%2f1381612828666220211153304
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fontanini&issn=1381-6128&title=Current+Pharmaceutical+Design&atitle=Long+Non-Coding+RNAs+and+Obesity%3A+New+Potential+Pathogenic+Biomarkers.&volume=28&issue=19&spage=1592&epage=1605&date=2022&doi=10.2174%2F1381612828666220211153304&pmid=35152861&sid=OVID:medline
+
+<566>
+Unique Identifier
+ 35141821
+Title
+ Adiposity and Smoking Mediate the Relationship Between Depression History and Inflammation Among Young Adults.
+Source
+ International Journal of Behavioral Medicine. 29(6):787-795, 2022 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang X; Evans RW; George CJ; Matthews KA; Kovacs M
+Author NameID
+ Yang, Xiao; ORCID: http://orcid.org/0000-0001-6421-2051
+Authors Full Name
+ Yang, Xiao; Evans, Rhobert W; George, Charles J; Matthews, Karen A; Kovacs, Maria.
+Institution
+ Yang, Xiao. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. yangxff225@gmail.com.
+ Evans, Rhobert W. Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
+ George, Charles J. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
+ Matthews, Karen A. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
+ Kovacs, Maria. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
+MeSH Subject Headings
+ Young Adult
+ Humans
+ Child
+ *Adiposity
+ Interleukin-6/me [Metabolism]
+ *Interleukin-6
+ Depression
+ Obesity
+ Inflammation
+ C-Reactive Protein/an [Analysis]
+ Body Mass Index
+ Biomarkers/me [Metabolism]
+ Smoking/ae [Adverse Effects]
+Keyword Heading
+ Adiposity
+ Depression
+ Inflammation
+ Mechanisms
+ Smoking
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Depression is associated with inflammation, but the mechanisms underlying this association are unclear. We examined adiposity and smoking as potential pathways through which childhood depression may lead to an elevated inflammatory status among young adults.
+
+ METHODS: The sample included 294 subjects with histories of depression (probands), 270 never-depressed siblings of probands (high-risk siblings), and 169 controls. C-reactive protein (CRP), interleukin-6 (IL-6), and soluble intercellular adhesion molecule-1 (sICAM-1) were assessed in serum samples. An adiposity score was computed from body mass index and waist circumference. Smoking behavior was evaluated during an interview. Mixed-effects models were used to test whether adiposity and smoking mediate the relationship between depression and inflammation.
+
+ RESULTS: Probands (p = .004), but not siblings (p = .071), had higher levels of sICAM-1 compared to controls. However, depression history and risk status had no direct effects on CRP (ps > .13) or IL-6 (ps > .16). Importantly, adiposity indirectly mediated the effect of group (probands vs. controls; siblings vs. controls) on all three inflammatory markers. Smoking indirectly mediated the effect of group (probands vs. controls; siblings vs. controls) on sICAM-1 only.
+
+ CONCLUSIONS: Among young adults, the adverse inflammatory consequences of depression history are significant for sICAM-1. Adiposity and smoking are pathways through which depression can indirectly impact several inflammatory markers, suggesting possible preventive interventions to improve the immunologic and cardiovascular health of depression-prone individuals. Copyright © 2022. International Society of Behavioral Medicine.
+Registry Number/Name of Substance
+ 0 (Interleukin-6). 9007-41-4 (C-Reactive Protein). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs12529-022-10060-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=1070-5503&title=International+Journal+of+Behavioral+Medicine&atitle=Adiposity+and+Smoking+Mediate+the+Relationship+Between+Depression+History+and+Inflammation+Among+Young+Adults.&volume=29&issue=6&spage=787&epage=795&date=2022&doi=10.1007%2Fs12529-022-10060-2&pmid=35141821&sid=OVID:medline
+
+<567>
+Unique Identifier
+ 35137784
+Title
+ Hypertension and Associated Lipid, Glucose, and Adiposity Parameters in School-Aged Adolescents in the Federal District, Brazil.
+Original Title
+ Hipertensao Arterial e Parametros Lipidicos, Glicidicos e de Adiposidade Associados em Adolescentes Escolares do Distrito Federal.
+Source
+ Arquivos Brasileiros de Cardiologia. 118(4):719-726, 2022 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lima LR; Okamura AB; Carvalho KMB; Dutra ES; Goncalves VSS
+Author NameID
+ Lima, Leticia Rocha; ORCID: https://orcid.org/0000-0002-3090-7696
+Authors Full Name
+ Lima, Leticia Rocha; Okamura, Aline Bassetto; Carvalho, Kenia Mara Baiocchi de; Dutra, Eliane Said; Goncalves, Vivian Siqueira Santos.
+Institution
+ Lima, Leticia Rocha. Departamento de Nutricao - Universidade de Brasilia, Brasilia, DF - Brasil.
+ Okamura, Aline Bassetto. Programa de Pos-graduacao em Saude Coletiva - Universidade de Brasilia, Brasilia, DF - Brasil.
+ Carvalho, Kenia Mara Baiocchi de. Programa de Pos-graduacao em Saude Coletiva - Universidade de Brasilia, Brasilia, DF - Brasil.
+ Carvalho, Kenia Mara Baiocchi de. Programa de Pos-graduacao em Nutricao Humana - Universidade de Brasilia, Brasilia, DF - Brasil.
+ Dutra, Eliane Said. Programa de Pos-graduacao em Nutricao Humana - Universidade de Brasilia, Brasilia, DF - Brasil.
+ Goncalves, Vivian Siqueira Santos. Programa de Pos-graduacao em Saude Coletiva - Universidade de Brasilia, Brasilia, DF - Brasil.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adiposity/ph [Physiology]
+ Adolescent
+ Biomarkers
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Brazil/ep [Epidemiology]
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Child
+ Cross-Sectional Studies
+ Glucose
+ Humans
+ Hypertension/ep [Epidemiology]
+ *Hypertension
+ Insulin Resistance/ph [Physiology]
+ *Insulin Resistance
+ Obesity
+ Triglycerides
+ Waist Circumference/ph [Physiology]
+Abstract
+ BACKGROUND: The prevalence of hypertension and other metabolic disorders has increased in young individuals. However, no representative studies have been conducted in the population of the Federal District, Brazil.
+
+ OBJECTIVE: To estimate the prevalence of hypertension and its association with lipid, glucose, and adiposity markers in school-aged adolescents living in the Federal District.
+
+ METHODS: This cross-sectional study included participants of the Study of Cardiovascular Risks in Adolescents (Portuguese acronym, ERICA). Blood pressure, blood glucose, glycated hemoglobin, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, body mass index (BMI), waist circumference, and economic, demographic, and sexual maturity variables were assessed. The data were analyzed in Stata, and the analysis was divided into different stages: descriptive, crude, and adjusted. Significant results were set at p < 0.05.
+
+ RESULTS: In total, 1,200 adolescents were included, and their mean age was 14.8 years. The prevalence of hypertension was 8% (95% confidence interval: 6.3; 9.9). Most parameters were associated with blood pressure in crude analysis. In adjusted analysis, glucose, lipid, and adiposity markers maintained the associations, and the highest magnitudes were those of BMI and HOMA-IR.
+
+ CONCLUSION: The study revealed a high prevalence of hypertension in adolescents living in the Federal District, and blood pressure levels were associated with other markers of lipid, glucose, and adiposity profile. The findings indicate the relevance of health surveillance for planning effective actions aimed at reversing this situation and preventing new cases.
+Other Abstract
+ Publisher
+ FUNDAMENTO: A prevalencia de hipertensao arterial sistemica (HAS) e de outros disturbios metabolicos tem aumentado em individuos jovens. Entretanto, nao ha estudos representativos sobre esse assunto com a populacao do Distrito Federal (DF).
+ OBJETIVO: Estimar a prevalencia de HAS e a sua associacao com parametros lipidicos, glicidicos e de adiposidade em adolescentes do DF.
+ METODOS: Trata-se de um estudo observacional transversal com participantes do Estudo de Riscos Cardiovasculares em Adolescentes (ERICA). Foram avaliados pressao arterial, glicemia sanguinea, hemoglobina glicada, insulina, modelo de avaliacao da homeostase da resistencia a insulina (HOMA-IR), triglicerideos, colesterol total, lipoproteina de alta densidade, lipoproteina de baixa densidade, indice de massa corporal (IMC) e perimetro da cintura, alem de variaveis economicas, demograficas e de maturacao sexual. A analise de dados foi feita no software Stata e foi dividida nas seguintes etapas: analises descritiva, bruta e ajustada. Considerou-se p < 0,05.
+ RESULTADOS: Foram incluidos 1.200 adolescentes com media de idade de 14,8 anos. A prevalencia de HAS foi de 8% (intervalo de confianca de 95%: 6,3; 9,9). A maioria dos parametros se associou com a PA na analise bruta; na ajustada, os parametros glicidicos, lipidicos e de adiposidade mantiveram a associacao, tendo IMC e HOMA-IR a maior magnitude na relacao.
+ CONCLUSAO: O estudo revelou elevada prevalencia de HAS em adolescentes do DF, e os niveis pressoricos apresentaram-se associados a outros marcadores de perfil lipidico, glicidico e de adiposidade, evidenciando a relevancia da vigilancia em saude para o planejamento de acoes efetivas para a reversao do quadro e prevencao de novos casos.
+ Language: Portuguese
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.36660%2fabc.20201240
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lima&issn=0066-782X&title=Arquivos+Brasileiros+de+Cardiologia&atitle=Hipertensao+Arterial+e+Parametros+Lipidicos%2C+Glicidicos+e+de+Adiposidade+Associados+em+Adolescentes+Escolares+do+Distrito+Federal.&volume=118&issue=4&spage=719&epage=726&date=2022&doi=10.36660%2Fabc.20201240&pmid=35137784&sid=OVID:medline
+
+<568>
+Unique Identifier
+ 35137553
+Title
+ Associations of Body Mass Index With Pain and the Mediating Role of Inflammatory Biomarkers in People With Hand Osteoarthritis.
+Source
+ Arthritis & Rheumatology. 74(5):810-817, 2022 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gloersen M; Steen Pettersen P; Neogi T; Jafarzadeh SR; Vistnes M; Thudium CS; Bay-Jensen AC; Sexton J; Kvien TK; Hammer HB; Haugen IK
+Author NameID
+ Gloersen, Marthe; ORCID: https://orcid.org/0000-0003-2233-4370
+ Steen Pettersen, Pernille; ORCID: https://orcid.org/0000-0003-0312-4255
+ Neogi, Tuhina; ORCID: https://orcid.org/0000-0002-9515-1711
+ Jafarzadeh, S Reza; ORCID: https://orcid.org/0000-0002-1099-9175
+ Kvien, Tore K; ORCID: https://orcid.org/0000-0002-8441-3093
+ Hammer, Hilde B; ORCID: https://orcid.org/0000-0001-7317-8991
+ Haugen, Ida K; ORCID: https://orcid.org/0000-0001-7810-2216
+Authors Full Name
+ Gloersen, Marthe; Steen Pettersen, Pernille; Neogi, Tuhina; Jafarzadeh, S Reza; Vistnes, Maria; Thudium, Christian S; Bay-Jensen, Anne-Christine; Sexton, Joe; Kvien, Tore K; Hammer, Hilde B; Haugen, Ida K.
+Institution
+ Gloersen, Marthe. Diakonhjemmet Hospital and University of Oslo, Oslo, Norway.
+ Steen Pettersen, Pernille. Diakonhjemmet Hospital and University of Oslo, Oslo, Norway.
+ Neogi, Tuhina. Boston University School of Medicine, Boston, Massachusetts.
+ Jafarzadeh, S Reza. Boston University School of Medicine, Boston, Massachusetts.
+ Vistnes, Maria. Diakonhjemmet Hospital, Oslo University Hospital Ulleval and University of Oslo, Oslo, Norway.
+ Thudium, Christian S. Nordic Bioscience A/S, Herlev, Denmark.
+ Bay-Jensen, Anne-Christine. Nordic Bioscience A/S, Herlev, Denmark.
+ Sexton, Joe. Diakonhjemmet Hospital, Oslo, Norway.
+ Kvien, Tore K. Diakonhjemmet Hospital and University of Oslo, Oslo, Norway.
+ Hammer, Hilde B. Diakonhjemmet Hospital and University of Oslo, Oslo, Norway.
+ Haugen, Ida K. Diakonhjemmet Hospital, Oslo, Norway.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Arthralgia/et [Etiology]
+ Australia
+ Biomarkers
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ Canada
+ Humans
+ *Leptin
+ Obesity/co [Complications]
+ Osteoarthritis, Knee/co [Complications]
+ *Osteoarthritis, Knee
+ Pain/et [Etiology]
+Abstract
+ OBJECTIVE: To examine the association of body mass index (BMI) with pain in people with hand osteoarthritis (OA), and explore whether this association, if causal, is mediated by systemic inflammatory biomarkers.
+
+ METHODS: In 281 Nor-Hand study participants, we estimated associations between BMI and hand pain, as measured by the Australian/Canadian Osteoarthritis Hand Index (AUSCAN; range 0-20) and Numerical Rating Scale (NRS; range 0-10); foot pain, as measured by NRS (range 0-10); knee/hip pain, as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC; range 0-20); painful total body joint count; and pain sensitization. We fit natural-effects models to estimate natural direct and natural indirect effects of BMI on pain through inflammatory biomarkers.
+
+ RESULTS: Each 5-unit increase in BMI was associated with more severe hand pain (on average increased AUSCAN by 0.64 [95% confidence interval (95% CI) 0.23, 1.08]), foot pain (on average increased NRS by 0.65 [95% CI 0.36, 0.92]), knee/hip pain (on average increased WOMAC by 1.31 [95% CI 0.87, 1.73]), generalized pain, and pain sensitization. Mediation analyses suggested that the effects of BMI on hand pain and painful total body joint count were partially mediated by leptin and high-sensitivity C-reactive protein (hsCRP), respectively. Effect sizes for mediation by leptin were larger for the hands than for the lower extremities, and were statistically significant for the hands only.
+
+ CONCLUSION: In people with hand OA, higher BMI is associated with greater pain severity in the hands, feet, and knees/hips. Systemic effects of obesity, measured by leptin, may play a larger mediating role for pain in the hands than in the lower extremities. Low-grade inflammation, measured by hsCRP, may contribute to generalized pain in overweight/obese individuals. Copyright © 2022 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2fart.42056
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gloersen&issn=2326-5191&title=Arthritis+%26+Rheumatology&atitle=Associations+of+Body+Mass+Index+With+Pain+and+the+Mediating+Role+of+Inflammatory+Biomarkers+in+People+With+Hand+Osteoarthritis.&volume=74&issue=5&spage=810&epage=817&date=2022&doi=10.1002%2Fart.42056&pmid=35137553&sid=OVID:medline
+
+<569>
+Unique Identifier
+ 35134121
+Title
+ Metabolomic signature: one step forward in the process of obtaining NAFLD patients' metabolic identity card.
+Source
+ American Journal of Clinical Nutrition. 115(3):603-605, 2022 03 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lonardo A
+Author NameID
+ Lonardo, Amedeo; ORCID: https://orcid.org/0000-0001-9886-0698
+Authors Full Name
+ Lonardo, Amedeo.
+Institution
+ Lonardo, Amedeo. Department of Internal Medicine, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Adiposity
+ Biomarkers/me [Metabolism]
+ Cohort Studies
+ Humans
+ Metabolomics
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1093%2fajcn%2fnqab399
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lonardo&issn=0002-9165&title=American+Journal+of+Clinical+Nutrition&atitle=Metabolomic+signature%3A+one+step+forward+in+the+process+of+obtaining+NAFLD+patients%27+metabolic+identity+card.&volume=115&issue=3&spage=603&epage=605&date=2022&doi=10.1093%2Fajcn%2Fnqab399&pmid=35134121&sid=OVID:medline
+
+<570>
+Unique Identifier
+ 35132354
+Title
+ Mitochondrial DNA and Epigenetics: Investigating Interactions with the One-Carbon Metabolism in Obesity.
+Source
+ Oxidative medicine & cellular longevity. 2022:9171684, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bordoni L; Petracci I; Mlodzik-Czyzewska M; Malinowska AM; Szwengiel A; Sadowski M; Gabbianelli R; Chmurzynska A
+Author NameID
+ Bordoni, Laura; ORCID: https://orcid.org/0000-0001-6968-1164
+ Petracci, Irene; ORCID: https://orcid.org/0000-0003-2433-7516
+ Mlodzik-Czyzewska, Monika; ORCID: https://orcid.org/0000-0001-6563-3640
+ Malinowska, Anna M; ORCID: https://orcid.org/0000-0002-7402-1328
+ Szwengiel, Artur; ORCID: https://orcid.org/0000-0003-4570-7221
+ Gabbianelli, Rosita; ORCID: https://orcid.org/0000-0003-0037-7740
+ Chmurzynska, Agata; ORCID: https://orcid.org/0000-0002-2045-0709
+Authors Full Name
+ Bordoni, Laura; Petracci, Irene; Mlodzik-Czyzewska, Monika; Malinowska, Anna M; Szwengiel, Artur; Sadowski, Marcin; Gabbianelli, Rosita; Chmurzynska, Agata.
+Institution
+ Bordoni, Laura. Unit of Molecular Biology and Nutrigenomics, University of Camerino, Camerino (MC), Italy.
+ Petracci, Irene. School of Advanced Studies, University of Camerino, Camerino (MC), Italy.
+ Mlodzik-Czyzewska, Monika. Department of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poland.
+ Malinowska, Anna M. Department of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poland.
+ Szwengiel, Artur. Department of Food Technology of Plant Origin, Poznan University of Life Sciences, Poland.
+ Sadowski, Marcin. Department of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poland.
+ Gabbianelli, Rosita. Unit of Molecular Biology and Nutrigenomics, University of Camerino, Camerino (MC), Italy.
+ Chmurzynska, Agata. Department of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poland.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Composition
+ Body Mass Index
+ *Carbon/me [Metabolism]
+ Case-Control Studies
+ Cohort Studies
+ DNA Copy Number Variations
+ DNA Methylation
+ *DNA, Mitochondrial/bl [Blood]
+ *DNA, Mitochondrial/ge [Genetics]
+ *Epigenesis, Genetic
+ Female
+ Glutathione/bl [Blood]
+ Humans
+ Male
+ Methylenetetrahydrofolate Reductase (NADPH2)/ge [Genetics]
+ Methylenetetrahydrofolate Reductase (NADPH2)/me [Metabolism]
+ Mitochondria/me [Metabolism]
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ Poland/ep [Epidemiology]
+ *Signal Transduction/ge [Genetics]
+ Young Adult
+Abstract
+ Mitochondrial DNA copy number (mtDNAcn) has been proposed for use as a surrogate biomarker of mitochondrial health, and evidence suggests that mtDNA might be methylated. Intermediates of the one-carbon cycle (1CC), which is duplicated in the cytoplasm and mitochondria, have a major role in modulating the impact of diet on the epigenome. Moreover, epigenetic pathways and the redox system are linked by the metabolism of glutathione (GSH). In a cohort of 101 normal-weight and 97 overweight/obese subjects, we evaluated mtDNAcn and methylation levels in both mitochondrial and nuclear areas to test the association of these marks with body weight, metabolic profile, and availability of 1CC intermediates associated with diet. Body composition was associated with 1CC intermediate availability. Reduced levels of GSH were measured in the overweight/obese group (p = 1.3*10-5). A high BMI was associated with lower LINE-1 (p = 0.004) and nominally lower methylenetetrahydrofolate reductase (MTHFR) gene methylation (p = 0.047). mtDNAcn was lower in overweight/obese subjects (p = 0.004) and independently correlated with MTHFR methylation levels (p = 0.005) but not to LINE-1 methylation levels (p = 0.086). DNA methylation has been detected in the light strand but not in the heavy strand of the mtDNA. Although mtDNA methylation in the light strand did not differ between overweight/obese and normal-weight subjects, it was nominally correlated with homocysteine levels (p = 0.035) and MTHFR methylation (p = 0.033). This evidence suggests that increased body weight might perturb mitochondrial-nuclear homeostasis affecting the availability of nutrients acting as intermediates of the one-carbon cycle. Copyright © 2022 Laura Bordoni et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (DNA, Mitochondrial). 7440-44-0 (Carbon). EC 1-5-1-20 (MTHFR protein, human). EC 1-5-1-20 (Methylenetetrahydrofolate Reductase (NADPH2)). GAN16C9B8O (Glutathione).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1155%2f2022%2f9171684
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bordoni&issn=1942-0994&title=Oxidative+medicine+%26+cellular+longevity&atitle=Mitochondrial+DNA+and+Epigenetics%3A+Investigating+Interactions+with+the+One-Carbon+Metabolism+in+Obesity.&volume=2022&issue=&spage=9171684&epage=&date=2022&doi=10.1155%2F2022%2F9171684&pmid=35132354&sid=OVID:medline
+
+<571>
+Unique Identifier
+ 35121749
+Title
+ A problem of proportions: estimates of metabolic associated fatty liver disease and liver fibrosis in Australian adults in the nationwide 2012 AusDiab Study.
+Source
+ Scientific Reports. 12(1):1956, 2022 02 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Farrell AM; Magliano DJ; Shaw JE; Thompson AJ; Croagh C; Ryan MC; Howell J
+Authors Full Name
+ Farrell, Ann M; Magliano, Dianna J; Shaw, Jonathan E; Thompson, Alexander J; Croagh, Catherine; Ryan, Marno C; Howell, Jessica.
+Institution
+ Farrell, Ann M. Department of Gastroenterology, St Vincent's Hospital Melbourne, 41 Victoria Pde, Melbourne, 3065, Australia. Ann.Farrell@svha.org.au.
+ Farrell, Ann M. University of Melbourne, Melbourne, Australia. Ann.Farrell@svha.org.au.
+ Magliano, Dianna J. Baker Heart and Diabetes Institute, Melbourne, Australia.
+ Shaw, Jonathan E. Baker Heart and Diabetes Institute, Melbourne, Australia.
+ Thompson, Alexander J. Department of Gastroenterology, St Vincent's Hospital Melbourne, 41 Victoria Pde, Melbourne, 3065, Australia.
+ Thompson, Alexander J. University of Melbourne, Melbourne, Australia.
+ Croagh, Catherine. Department of Gastroenterology, St Vincent's Hospital Melbourne, 41 Victoria Pde, Melbourne, 3065, Australia.
+ Croagh, Catherine. University of Melbourne, Melbourne, Australia.
+ Ryan, Marno C. Department of Gastroenterology, St Vincent's Hospital Melbourne, 41 Victoria Pde, Melbourne, 3065, Australia.
+ Ryan, Marno C. University of Melbourne, Melbourne, Australia.
+ Howell, Jessica. Department of Gastroenterology, St Vincent's Hospital Melbourne, 41 Victoria Pde, Melbourne, 3065, Australia.
+ Howell, Jessica. University of Melbourne, Melbourne, Australia.
+ Howell, Jessica. Disease Elimination, Burnett Institute, Melbourne, Australia.
+ Howell, Jessica. Department of epidemiology and preventive medicine, Monash university, Clayton, 3168, Australia.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Alanine Transaminase/bl [Blood]
+ Australia/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ Clinical Enzyme Tests
+ Cross-Sectional Studies
+ Diabetes Mellitus/di [Diagnosis]
+ *Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Health Surveys
+ Humans
+ Liver Cirrhosis/di [Diagnosis]
+ *Liver Cirrhosis/ep [Epidemiology]
+ Male
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ *Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Predictive Value of Tests
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Time Factors
+ Up-Regulation
+Abstract
+ Metabolic Associated Fatty Liver Disease (MAFLD) is the most common cause of liver disease in Australia, but prevalence data are limited. We aimed to describe the frequency of alanine aminotransferase (ALT) elevation, and MAFLD within a large prospective Australian cohort. Cross-sectional analysis of the 2012 survey of the Australian Diabetes, Obesity and Lifestyle (AusDiab) study which included 4747 Australian adults (aged 34-97 yrs) was performed. Frequency of ALT elevation (men >= 40 IU/L, women >= 30 IU/L) and MAFLD (Fatty Liver Index (FLI) > 60 alongside metabolic risk factors) was determined and risk of advanced fibrosis stratified using the BARD score. Elevated ALT was found in 13% of the cohort, including 22% of people with diabetes, 18% with obesity, and 17% with the metabolic syndrome. 37% of the cohort had MAFLD, and those with MAFLD were more likely to be older (OR 1.01 per 1 year (95% CI 1.00-1.02)), male (OR 1.37 (95% CI 1.17-1.59)), have ALT elevation (OR 3.21 (95% CI 2.59-3.99)), diabetes (OR 3.39 (95% CI 2.61-4.39)), lower HDL-C (OR 0.15 per 1 mmol/L (95% CI 0.12-0.19)), higher diastolic blood pressure (OR 1.05 per 10 mmHg (95% CI 1.05-1.06)), a sedentary lifestyle (OR 1.99 (95% CI 1.59-2.50)) and less likely to have tertiary education (OR 0.81 (95% CI 0.7-0.94) compared to those without MAFLD. Of those with MAFLD, 61% had a BARD score suggesting risk of advanced fibrosis and 22% had an elevated ALT. Over 10% of this Australian cohort had elevated ALT, and 37% had MAFLD, with many at risk for advanced fibrosis. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41598-022-05168-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Farrell&issn=2045-2322&title=Scientific+Reports&atitle=A+problem+of+proportions%3A+estimates+of+metabolic+associated+fatty+liver+disease+and+liver+fibrosis+in+Australian+adults+in+the+nationwide+2012+AusDiab+Study.&volume=12&issue=1&spage=1956&epage=&date=2022&doi=10.1038%2Fs41598-022-05168-0&pmid=35121749&sid=OVID:medline
+
+<572>
+Unique Identifier
+ 35115003
+Title
+ The effect of periodic ketogenic diet on newly diagnosed overweight or obese patients with type 2 diabetes.
+Source
+ BMC Endocrine Disorders. 22(1):34, 2022 Feb 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li S; Lin G; Chen J; Chen Z; Xu F; Zhu F; Zhang J; Yuan S
+Author NameID
+ Li, Sumei; ORCID: http://orcid.org/0000-0002-6963-5309
+Authors Full Name
+ Li, Sumei; Lin, Guoxin; Chen, Jinxing; Chen, Zhenxin; Xu, Feipeng; Zhu, Feng; Zhang, Jintian; Yuan, Shouping.
+Institution
+ Li, Sumei. Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, Fujian Medical University, Putian, Fujian Province, People's Republic of China. ptsyy.lsm@163.com.
+ Lin, Guoxin. Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, Fujian Medical University, Putian, Fujian Province, People's Republic of China.
+ Chen, Jinxing. Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, Fujian Medical University, Putian, Fujian Province, People's Republic of China.
+ Chen, Zhenxin. Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, Fujian Medical University, Putian, Fujian Province, People's Republic of China.
+ Xu, Feipeng. Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, Fujian Medical University, Putian, Fujian Province, People's Republic of China.
+ Zhu, Feng. Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, Fujian Medical University, Putian, Fujian Province, People's Republic of China.
+ Zhang, Jintian. Department of Pathology, Putian University, Medical University, Fujian, China.
+ Yuan, Shouping. Department o f Endocrinology, Teaching Hospital, The First Hospital of Putian, Fujian Medical University, Putian, Fujian Province, People's Republic of China.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 2/dh [Diet Therapy]
+ *Diet, Ketogenic
+ Female
+ Humans
+ Male
+ *Obesity/dh [Diet Therapy]
+ *Overweight/dh [Diet Therapy]
+Keyword Heading
+ Being overweight. Type 2 diabetes
+ Ketogenic diet
+ Newly diagnosis
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The ketogenic diet (KD) is characterized by fat as a substitute of carbohydrates for the primary energy source. There is a large number of overweight or obese people with type 2 diabetes mellitus (T2DM), while this study aims to observe periodic ketogenic diet for effect on overweight or obese patients newly diagnosed as T2DM.
+
+ METHODS: A total of 60 overweight or obese patients newly diagnosed as T2DM were randomized into two groups: KD group, which was given ketogenic diet, and control group, which was given routine diet for diabetes, 30 cases in each group. Both dietary patterns lasted 12 weeks, and during the period, the blood glucose, blood lipid, body weight, insulin, and uric acid before and after intervention, as well as the significance for relevant changes, were observed.
+
+ RESULTS: For both groups, the weight, BMI(body mass index), Waist, TG (triglyceride), TC(cholesterol), LDL (low-density lipoprotein cholesterol), HDL (high-density lipoprotein cholesterol), FBG (fasting glucose), FINS (fasting insulin), HbA1c (glycosylated hemoglobin) were decreased after intervention (P < 0.05), while the decrease rates in the KD group was more significant than the control group. However, UA(serum uric acid) in the KD group showed an upward trend, while in the control group was not changed significantly (P > 0.05). The willingness to adhere to the ketogenic diet over the long term was weaker than to the routine diet for diabetes.
+
+ CONCLUSION: Among the overweight or obese patients newly diagnosed as type 2 diabetes mellitus, periodic ketogenic diet can not only control the body weight, but also control blood glucose and lipid, but long-term persistence is difficult. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1186%2fs12902-022-00947-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=The+effect+of+periodic+ketogenic+diet+on+newly+diagnosed+overweight+or+obese+patients+with+type+2+diabetes.&volume=22&issue=1&spage=34&epage=&date=2022&doi=10.1186%2Fs12902-022-00947-2&pmid=35115003&sid=OVID:medline
+
+<573>
+Unique Identifier
+ 35113435
+Title
+ Effect of aerobic exercise with diet on sex hormones and selected coagulation biomarkers in obese postmenopausal women: a randomized clinical trial.
+Source
+ European Review for Medical & Pharmacological Sciences. 26(2):591-597, 2022 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elsayed MM; Rabiee A; Elrefaye GE; Elsisi HF
+Authors Full Name
+ Elsayed, M M; Rabiee, A; Elrefaye, G E; Elsisi, H F.
+Institution
+ Elsayed, M M. Department of Physical Therapy for Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Cairo University, Egypt. marwadd999@gmail.com.
+MeSH Subject Headings
+ Biomarkers
+ Diet
+ Estradiol
+ Exercise
+ Female
+ Gonadal Steroid Hormones
+ Humans
+ Obesity/th [Therapy]
+ *Postmenopause
+ Testosterone
+ *Tissue Plasminogen Activator
+Abstract
+ OBJECTIVE: The current study determined the effect of aerobic training and diet program versus diet only on sex hormones and selected coagulation biomarkers in obese postmenopausal women. Further, the correlation between the measured variables after the intervention was identified.
+
+ PATIENTS AND METHODS: Eligible 40 women were distributed into two equal groups: the experimental group that received aerobic training three times per week for 12 weeks along with a balanced diet, and the control group that received a balanced diet only. Changes in weight, body mass index, sex hormones, and coagulation biomarkers were assessed pre-and post-intervention. The correlation between evaluated variables was assessed.
+
+ RESULTS: Both groups demonstrated a significant difference in sex hormones (i.e., a substantial decrease in estradiol, total testosterone, free testosterone, and a substantial increase in sex hormone-binding globulin) and coagulation biomarkers (a considerable reduction in plasminogen activator inhibitor-1 activity, fibrinogen, and a significant increase in tissue plasminogen activator, prothrombin time, and cephalin-kaolin coagulation time). This discrepancy was highly significant in the experimental group (p < 0.01) relative to the control group (p < 0.05), and there was a strong link between sex hormones and coagulation biomarkers (p <= 0.05). Conversely, no correlation between variables was noticed in the control group (p > 0.05).
+
+ CONCLUSIONS: Aerobic exercise along with a balanced diet modulates sex hormones level, improves homeostasis balance in postmenopausal women, and reduces the potential risk of cardiovascular disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Gonadal Steroid Hormones). 3XMK78S47O (Testosterone). 4TI98Z838E (Estradiol). EC 3-4-21-68 (Tissue Plasminogen Activator).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.26355%2feurrev_202201_27886
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elsayed&issn=1128-3602&title=European+Review+for+Medical+%26+Pharmacological+Sciences&atitle=Effect+of+aerobic+exercise+with+diet+on+sex+hormones+and+selected+coagulation+biomarkers+in+obese+postmenopausal+women%3A+a+randomized+clinical+trial.&volume=26&issue=2&spage=591&epage=597&date=2022&doi=10.26355%2Feurrev_202201_27886&pmid=35113435&sid=OVID:medline
+
+<574>
+Unique Identifier
+ 35094602
+Title
+ The Association of Blood Biomarkers and Body Mass Index in Knee Osteoarthritis: A Cross-Sectional Study.
+Source
+ Cartilage. 13(1):19476035211069251, 2022 Jan-Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schadler P; Lohberger B; Thauerer B; Faschingbauer M; Kullich W; Stradner MH; Leithner A; Ritschl V; Omara M; Steinecker-Frohnwieser B
+Author NameID
+ Schadler, Paul; ORCID: https://orcid.org/0000-0001-9633-1469
+ Thauerer, Bettina; ORCID: https://orcid.org/0000-0001-8357-4082
+ Ritschl, Valentin; ORCID: https://orcid.org/0000-0001-8763-8215
+Authors Full Name
+ Schadler, Paul; Lohberger, Birgit; Thauerer, Bettina; Faschingbauer, Martin; Kullich, Werner; Stradner, Martin Helmut; Leithner, Andreas; Ritschl, Valentin; Omara, Maisa; Steinecker-Frohnwieser, Bibiane.
+Institution
+ Schadler, Paul. Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
+ Lohberger, Birgit. Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
+ Lohberger, Birgit. Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Saalfelden, Austria.
+ Thauerer, Bettina. Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Saalfelden, Austria.
+ Faschingbauer, Martin. Department of Orthopaedic Surgery, University Hospital Ulm, Ulm, Germany.
+ Kullich, Werner. Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Saalfelden, Austria.
+ Stradner, Martin Helmut. Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
+ Leithner, Andreas. Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
+ Ritschl, Valentin. Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
+ Ritschl, Valentin. Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria.
+ Omara, Maisa. Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria.
+ Omara, Maisa. Institute for Outcomes Research, Medical University of Vienna, Vienna, Austria.
+ Steinecker-Frohnwieser, Bibiane. Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Saalfelden, Austria.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Cross-Sectional Studies
+ Humans
+ Leptin
+ Metabolic Syndrome/co [Complications]
+ *Metabolic Syndrome
+ Obesity/co [Complications]
+ Osteoarthritis, Knee/co [Complications]
+ *Osteoarthritis, Knee
+ Resistin
+Keyword Heading
+ FABP4
+ biomarkers
+ knee osteoarthritis
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Despite massive efforts, there are no diagnostic blood biomarkers for knee osteoarthritis (KOA). This study investigated several candidate diagnostic biomarkers and the metabolic phenotype in end-stage KOA in the context of obesity.
+
+ DESIGN: In this cross-sectional study, adult patients undergoing knee arthroplasty were enrolled and KOA severity was assessed using the Lequesne index. Blood biomarkers with an important role in obesity, the metabolic syndrome, or KOA (oxidized form of low-density lipoprotein [oxLDL], advanced glycation end product [AGE], soluble AGE receptor [sRAGE], fatty acid binding protein 4 [FABP4], phospholipase A2 group IIA [PLA2G2A], fibroblast growth factor 23 [FGF-23], ghrelin, leptin, and resistin) were measured using enzyme-linked immunosorbent assay (ELISA; n = 70) or Luminex technique (subgroup of n = 35). H1-NMR spectroscopy was used for the quantification of metabolite levels (subgroup of n = 31). The hip-knee-ankle angle was assessed. Multivariable and multivariate regression analysis was used to examine the relationship of biomarkers with body mass index (BMI) and KOA severity in complete case and multiple imputation analysis.
+
+ RESULTS: While most of the investigated biomarkers were not associated with KOA severity, FABP4 and leptin were found to correlate with BMI and gender. Resistin was associated with Lequesne index in complete case analysis. Using a targeted metabolomics approach, BMI-dependent changes in the metabolome were hardly visible.
+
+ CONCLUSIONS: Our findings confirm studies on FABP4, leptin, and resistin with regard to obesity and the metabolic syndrome. There was no association of the investigated biomarkers with KOA severity, most likely due to the patient selection (end-stage KOA patients). Based on this absence of BMI-dependent changes in the metabolome, we might assume that BMI is not correlated with KOA severity in this specific patient group.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). 0 (Resistin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1177%2f19476035211069251
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schadler&issn=1947-6035&title=Cartilage&atitle=The+Association+of+Blood+Biomarkers+and+Body+Mass+Index+in+Knee+Osteoarthritis%3A+A+Cross-Sectional+Study.&volume=13&issue=1&spage=19476035211069251&epage=&date=2022&doi=10.1177%2F19476035211069251&pmid=35094602&sid=OVID:medline
+
+<575>
+Unique Identifier
+ 35093938
+Title
+ S-Klotho level and physiological markers of cardiometabolic risk in healthy adult men.
+Source
+ Aging. 14(2):708-727, 2022 01 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zelazniewicz A; Nowak-Kornicka J; Pawlowski B
+Authors Full Name
+ Zelazniewicz, Agnieszka; Nowak-Kornicka, Judyta; Pawlowski, Boguslaw.
+Institution
+ Zelazniewicz, Agnieszka. Department of Human Biology, University of Wroclaw, Wroclaw, Poland.
+ Nowak-Kornicka, Judyta. Department of Human Biology, University of Wroclaw, Wroclaw, Poland.
+ Pawlowski, Boguslaw. Department of Human Biology, University of Wroclaw, Wroclaw, Poland.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Cardiovascular Diseases/co [Complications]
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Cross-Sectional Studies
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Risk Factors
+ Testosterone
+Keyword Heading
+ aging
+ cardiometabolic risk
+ early marker
+ healthspan
+ longevity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ S-Klotho is perceived as a biomarker of healthy aging that has been shown to be inversely associated with cardiometabolic risk in elderly individuals. The aim of this study was to test if s-Klotho level is associated with cardiometabolic risk markers in younger healthy men in order to verify the possible role of s-Klotho level as an early marker of cardiometabolic risk. A cross-sectional study was conducted among 186 healthy men (Mage=35.33, SDage=3.47) from a Western urban population. Serum basal levels of s-Klotho, lipid profile, homocysteine, glycemia markers, C-reactive protein, liver transaminases and creatinine were evaluated. Also, blood pressure was measured and cardiometabolic risk score and homeostatic model assessment for insulin resistance (HOMA-IR) were calculated. Testosterone and cortisol levels, self-reported psychological stress, physical activity, smoking in the past, alcohol use and body adiposity were controlled for. We found no relationship between levels of s-Klotho and physiological markers of cardiometabolic risk in the studied population. The results were similar when controlled for adiposity, testosterone level, physical activity, alcohol use and smoking in the past. We suggest that s-Klotho level is not an early marker of cardiometabolic risk in younger middle-aged healthy men.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3XMK78S47O (Testosterone).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.18632%2faging.203861
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zelazniewicz&issn=1945-4589&title=Aging&atitle=S-Klotho+level+and+physiological+markers+of+cardiometabolic+risk+in+healthy+adult+men.&volume=14&issue=2&spage=708&epage=727&date=2022&doi=10.18632%2Faging.203861&pmid=35093938&sid=OVID:medline
+
+<576>
+Unique Identifier
+ 35092490
+Title
+ Metabolomics based biomarker identification of anti-diabetes and anti-obesity properties of Malaysian herbs. [Review]
+Source
+ Metabolomics. 18(2):12, 2022 Jan 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Benchoula K; Vohra MS; Parhar IS; Hwa WE
+Author NameID
+ Hwa, Wong Eng; ORCID: https://orcid.org/0000-0001-9322-772X
+Authors Full Name
+ Benchoula, Khaled; Vohra, Muhammad Sufyan; Parhar, Ishwar S; Hwa, Wong Eng.
+Institution
+ Benchoula, Khaled. School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
+ Vohra, Muhammad Sufyan. School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
+ Parhar, Ishwar S. Jeffrey Cheah School of Medicine & Health Sciences, Monash University (Malaysia), BRIMS, Jalan Lagoon Selatan, Bandar Sunway, 47500, Subang Jaya, Selangor, Malaysia.
+ Hwa, Wong Eng. School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia. EngHwa.Wong@taylors.edu.my.
+MeSH Subject Headings
+ Biomarkers
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 2
+ Humans
+ Malaysia
+ Metabolomics
+ Obesity/dt [Drug Therapy]
+Keyword Heading
+ *Diabetes
+ *Malaysian herbs
+ *Metabolomics
+ *Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Today, obesity affects over one-third of the global population and is hugely considered the Industrial Revolution's side effect. This multi-factorial disease is continuously spreading across developing countries, including the Middle East and Southeast Asia region, where Malaysia and Darussalam Brunei are the most affected. The sedentary lifestyle and availability of surplus foods have dramatically increased the number of individuals with type 2 diabetes in these countries. Thus, an adequate medical strategy must be developed urgently to address and remedy these diseases. Natural sources have been attracting attention, especially in Malaysia, where most land areas are under plant cover. Metabolomics, as a prophylactic technique, has been used extensively in Malaysia to investigate the potential use and benefits of herbs to combat obesity and diabetes.
+
+ AIM OF REVIEW: This review aims to explain the application of the metabolomics approach in the study of anti-diabetes and anti-obesity activity of Malaysian herbs to identify the stand-up point for future advancement in using these herbs as a primary source for drug exploration.
+
+ KEY SCIENTIFIC CONCEPTS OF REVIEW: This review provides an overview of using metabolomics technique in studying the anti-diabetes and anti-obesity activity of Malaysian herbs. Specific emphasis is given to the changed metabolites in both in vivo and in vitro treatment of Malaysia herbs that might be future drugs for treating diabetes and obesity. Copyright © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs11306-022-01870-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Benchoula&issn=1573-3882&title=Metabolomics&atitle=Metabolomics+based+biomarker+identification+of+anti-diabetes+and+anti-obesity+properties+of+Malaysian+herbs.&volume=18&issue=2&spage=12&epage=&date=2022&doi=10.1007%2Fs11306-022-01870-2&pmid=35092490&sid=OVID:medline
+
+<577>
+Unique Identifier
+ 35092252
+Title
+ GALANIN LEVELS IN HYPERTENSIVE PATIENTS WITH OBESITY.
+Source
+ Wiadomosci Lekarskie. 75(1):79-84, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kravchun PG; Kadykova OI; Herasymchuk US
+Authors Full Name
+ Kravchun, Pavlo G; Kadykova, Olga I; Herasymchuk, Uliana S.
+Institution
+ Kravchun, Pavlo G. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+ Kadykova, Olga I. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+ Herasymchuk, Uliana S. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers
+ Female
+ *Galanin
+ Humans
+ Hypertension/co [Complications]
+ Hypertension/ep [Epidemiology]
+ *Hypertension
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity, Abdominal
+Keyword Heading
+ Galanin
+ arterial hypertension
+ carbohydrate metabolism
+ lipid metabolism
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The aim: To study the level of Galanin concentration in hypertensive patients with obesity, and to identify how the degree of hypertension and the degree of obesity affect the level of Galanin in patients with this comorbid pathology.
+
+ PATIENTS AND METHODS: Materials and methods: The study included 58 patients with hypertension. Grade 1 was diagnosed in 12 (20.69%), grade 2 - 16 (27.59%), grade 3 - 30 (51.72%) examined patients. Of the patients enrolled to study, 32 were women and 26 were men, 32 to 79 years old (mean age - 57,5+/-10.11 years).
+
+ RESULTS: Results: The level of Galanin in all groups of hypertensive patients was significantly increased compared to the control group (p < 0.001). The concentration of the latter in the blood serum gradually increases according to the degree of hypertension, while (p<0.01), and the maximum level of Galanin was observed in group of patients with grade 3 hypertension (Me 164.47 pg/mL). The level of Galanin concentration in all subgroups of patients, depending on the presence and degree of obesity, was significantly increased compared to the control group (p < 0.001), the maximum level of Galanin was in the group with hypertension and obesity of 3 degrees (Me = 166.48 pg/mL).
+
+ CONCLUSION: Conclusions: In hypertensive patients with obesity, a significant increase in the concentration of Galanin was detected; most pronounced in arterial hypertension grade 3 and obesity grade 3. Galanin is possibly a biomarker of cardiovascular risk in a cohort of patients with abdominal obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 88813-36-9 (Galanin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&AN=35092252
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kravchun&issn=0043-5147&title=Wiadomosci+Lekarskie&atitle=GALANIN+LEVELS+IN+HYPERTENSIVE+PATIENTS+WITH+OBESITY.&volume=75&issue=1&spage=79&epage=84&date=2022&doi=&pmid=35092252&sid=OVID:medline
+
+<578>
+Unique Identifier
+ 35090002
+Title
+ Gut Dysfunction Markers Are Associated With Body Composition in Youth Living With Perinatally Acquired Human Immunodeficiency Virus.
+Source
+ Clinical Infectious Diseases. 75(6):945-952, 2022 09 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dirajlal-Fargo S; Jacobson DL; Yu W; Mirza A; Geffner ME; Jao J; McComsey GA
+Author NameID
+ Dirajlal-Fargo, Sahera; ORCID: https://orcid.org/0000-0001-9945-9062
+Authors Full Name
+ Dirajlal-Fargo, Sahera; Jacobson, Denise L; Yu, Wendy; Mirza, Ayesha; Geffner, Mitchell E; Jao, Jennifer; McComsey, Grace A.
+Institution
+ Dirajlal-Fargo, Sahera. Rainbow Babies and Children's Hospital and Case Western Reserve University, Cleveland, Ohio, USA.
+ Jacobson, Denise L. Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
+ Yu, Wendy. Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
+ Mirza, Ayesha. University of Florida Health, Jacksonville, Florida, USA.
+ Geffner, Mitchell E. Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California, USA.
+ Jao, Jennifer. Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
+ McComsey, Grace A. Rainbow Babies and Children's Hospital and Case Western Reserve University, Cleveland, Ohio, USA.
+MeSH Subject Headings
+ Absorptiometry, Photon/mt [Methods]
+ Adiposity
+ Adolescent
+ Biomarkers
+ Body Composition
+ Child
+ Cohort Studies
+ Fatty Acid-Binding Proteins
+ Female
+ HIV
+ HIV Infections/co [Complications]
+ HIV Infections/dt [Drug Therapy]
+ *HIV Infections
+ Humans
+ *Lipopolysaccharides
+ Male
+ Obesity
+ RNA
+Keyword Heading
+ HIV
+ adiposity
+ intestinal integrity
+ intestinal permeability
+ pediatric anthropometrics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The association between gut dysfunction and body fat composition in youth living with perinatal human immunodeficiency virus infection (YPHIV) has not been investigated.
+
+ METHODS: We included YPHIV aged 7-19 years from the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol with plasma available within 6 months of baseline whole-body dual energy x-ray absorptiometry (DXA) and HIV RNA <=1000 copies/mL within 3 months of baseline DXA and a second DXA 2 years later. Plasma markers of bacterial translocation and gut barrier dysfunction (lipopolysaccharide binding protein [LBP], zonulin, and intestinal fatty acid binding protein [I-FABP]) were measured at baseline by enzyme-linked immunosorbent assay and log10 transformed. Adiposity outcomes included percentage total body, truncal, and extremity fat in kilograms from DXA. Linear regression models were fit using generalized estimating equations to assess associations of baseline gut markers (log10) on adiposity outcomes at baseline and 2 years, adjusted for demographic variables, current antiretroviral therapy exposure, and physical activity.
+
+ RESULTS: Two hundred sixty-one youth were included; 128 had a second DXA. Median age at first DXA was 12 years (interquartile range, 10-14 years), 49% were female, and 69% were Black. After adjustment for potential confounders, log10 LBP was positively associated with percentage total body fat at baseline (beta = 4.08, P < .01) and zonulin with adiposity measures at both time points (beta = .94 to 6.50, P <= .01). I-FABP was inversely associated with percentage total body fat at baseline and year 2 (beta = -2.36 and -3.01, respectively, P <= .02).
+
+ CONCLUSIONS: Despite viral suppression, gut damage and the resultant bacterial translocation are associated with body composition measures in YPHIV. Copyright © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acid-Binding Proteins). 0 (Lipopolysaccharides). 63231-63-0 (RNA).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1093%2fcid%2fciac053
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dirajlal-Fargo&issn=1058-4838&title=Clinical+Infectious+Diseases&atitle=Gut+Dysfunction+Markers+Are+Associated+With+Body+Composition+in+Youth+Living+With+Perinatally+Acquired+Human+Immunodeficiency+Virus.&volume=75&issue=6&spage=945&epage=952&date=2022&doi=10.1093%2Fcid%2Fciac053&pmid=35090002&sid=OVID:medline
+
+<579>
+Unique Identifier
+ 35081533
+Title
+ Effect of BMI on the Thermogenic Response to Cold Exposure and Associated Changes in Metabolism and Browning Markers in Adult Humans.
+Source
+ Obesity Facts. 15(3):405-415, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mengel LA; Nemati Moud B; Seidl H; Mesas-Fernandez A; Seeliger C; Brandl B; Skurk T; Holzapfel C; Claussnitzer M; Hauner H
+Authors Full Name
+ Mengel, Laura Aline; Nemati Moud, Bahareh; Seidl, Hatti; Mesas-Fernandez, Alberto; Seeliger, Claudine; Brandl, Beate; Skurk, Thomas; Holzapfel, Christina; Claussnitzer, Melina; Hauner, Hans.
+Institution
+ Mengel, Laura Aline. Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
+ Mengel, Laura Aline. ZIEL Institute for Food and Health, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Mengel, Laura Aline. Else Kroner-Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Nemati Moud, Bahareh. Else Kroner-Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Seidl, Hatti. Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
+ Mesas-Fernandez, Alberto. Else Kroner-Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Seeliger, Claudine. Else Kroner-Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Brandl, Beate. ZIEL Institute for Food and Health, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Brandl, Beate. Else Kroner-Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Skurk, Thomas. ZIEL Institute for Food and Health, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Skurk, Thomas. Else Kroner-Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Holzapfel, Christina. Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
+ Claussnitzer, Melina. Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
+ Claussnitzer, Melina. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
+ Hauner, Hans. Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
+ Hauner, Hans. ZIEL Institute for Food and Health, Technical University of Munich, Freising-Weihenstephan, Germany.
+ Hauner, Hans. Else Kroner-Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany.
+MeSH Subject Headings
+ Adipose Tissue, Brown/me [Metabolism]
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Energy Metabolism
+ Female
+ Humans
+ Male
+ Obesity/me [Metabolism]
+ Overweight/me [Metabolism]
+ *Overweight
+ Thermogenesis/ph [Physiology]
+ *Thermogenesis
+ Young Adult
+Keyword Heading
+ Brown adipose tissue
+ Browning markers
+ Cold exposure
+ Nonshivering thermogenesis
+ Resting energy expenditure
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Brown adipose tissue (BAT) serves to produce heat by nonshivering thermogenesis. Activation of BAT increases energy expenditure and is seen as a putative strategy to treat obesity. There are conflicting data on the capacity for cold-induced thermogenesis in individuals with higher BMI.
+
+ METHODS: To investigate the effect of BMI on cold-induced stimulation of energy expenditure, changes in the metabolic profile, and the expression of browning markers in subcutaneous white adipose tissue (scWAT), healthy adults (N = 173, 50.9% females) with a median age of 26.0 (interquartile range [IQR]: 23.0; 28.0) years and a median body mass index (BMI) of 23.6 [IQR: 21.9; 26.6] kg/m2 were exposed to short-term mild cold exposure (CE). Resting energy expenditure (REE) was measured by indirect calorimetry and blood sampling was conducted at baseline and after CE. In a subgroup of participants with obesity, subcutaneous abdominal fat biopsies were taken before and after CE.
+
+ RESULTS: The cold-induced median increase in REE was 74 (IQR: -28; 241) kcal/day (p < 0.001). This increase negatively correlated with BMI (p < 0.001). Participants with BMI 18.5-24.9 kg/m2 displayed a significant median increase of 103 kcal/day (p < 0.001), participants with overweight or obesity were not able to increase REE (23, p = 0.468 or -30 kcal/day, p = 0.917, respectively). In participants with obesity, expression of cell death activator in scWAT after CE was upregulated in females (p = 0.034).
+
+ CONCLUSIONS: Persons with overweight and obesity do not increase REE in response to CE, presumably reflecting lower BAT activity. Likewise, the metabolic response to cold is diminished in participants with elevated BMI. Copyright © 2022 The Author(s). Published by S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1159%2f000522218
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mengel&issn=1662-4025&title=Obesity+Facts&atitle=Effect+of+BMI+on+the+Thermogenic+Response+to+Cold+Exposure+and+Associated+Changes+in+Metabolism+and+Browning+Markers+in+Adult+Humans.&volume=15&issue=3&spage=405&epage=415&date=2022&doi=10.1159%2F000522218&pmid=35081533&sid=OVID:medline
+
+<580>
+Unique Identifier
+ 35074310
+Title
+ Adjusting Ferritin Concentrations for Nonclinical Inflammation in Adolescents with Overweight or Obesity.
+Source
+ Journal of Pediatrics. 244:125-132.e1, 2022 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pompano LM; Correa-Burrows P; Burrows R; Blanco E; Lozoff B; Gahagan S
+Authors Full Name
+ Pompano, Laura M; Correa-Burrows, Paulina; Burrows, Raquel; Blanco, Estela; Lozoff, Betsy; Gahagan, Sheila.
+Institution
+ Pompano, Laura M. Department of Child Development and Community Health, University of California San Diego, La Jolla, CA.
+ Correa-Burrows, Paulina. Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile. Electronic address: paulina.correa@inta.uchile.cl.
+ Burrows, Raquel. Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile.
+ Blanco, Estela. Department of Child Development and Community Health, University of California San Diego, La Jolla, CA; Departamento de Salud Publica, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile.
+ Lozoff, Betsy. Center for Human Growth and Development, University of Michigan, Ann Arbor, MI.
+ Gahagan, Sheila. Department of Child Development and Community Health, University of California San Diego, La Jolla, CA.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ C-Reactive Protein/an [Analysis]
+ Cross-Sectional Studies
+ Female
+ *Ferritins
+ Humans
+ Inflammation
+ Iron/me [Metabolism]
+ Male
+ Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ *Overweight
+Keyword Heading
+ BRINDA
+ adolescents
+ correction factor
+ ferritin
+ inflammation
+ obesity
+ overweight
+ regression correction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To compare approaches for adjusting serum ferritin concentrations for inflammation in Chilean adolescents with overweight and obesity.
+
+ STUDY DESIGN: Cross-sectional data from 518 adolescents (aged 16-17 years; 48% females) from Santiago, Chile were analyzed. Several approaches were compared for estimating the prevalence of depleted iron stores (defined as serum ferritin <15 mug/L), including unadjusted prevalence and higher cutoffs for various subgroups (excluding participants with inflammation), correction factors, and regression corrections. A "reference" prevalence estimate was calculated as the prevalence of serum ferritin <15 mug/L in normal weight individuals without inflammation. Each adjustment approach was compared with this reference prevalence.
+
+ RESULTS: The sample comprised 61.2% normal weight, 23.7% overweight, and 15.1% obese individuals. The prevalence of inflammation (marked by C-reactive protein level >5.0 mg/L) was 6.3%, 8.1%, and 14.1% in the 3 groups, respectively. The correction factor approaches produced adjusted estimates closest to the reference estimate (24.1%-24.7% vs 22.9%), followed by the regression corrections (24.7%-25.1% vs 22.9%). Applying a higher serum ferritin cutoff (30 mug/L) to all participants or to participants with overweight/obesity produced adjusted estimates farthest from the reference (59.5% and 35.3%, respectively).
+
+ CONCLUSIONS: Adjusting serum ferritin concentration may be necessary when assessing iron status in populations with high rates of overweight/obesity. After reviewing 6 approaches for adjusting for the influence of inflammation, this study suggests that using correction factors may be the most appropriate approach for adjusting serum ferritin in Chilean adolescents. Further research is needed to determine the optimal approach for adjusting serum ferritin concentrations for weight-related inflammation in broader populations. Copyright © 2022 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein). 9007-73-2 (Ferritins). E1UOL152H7 (Iron).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.jpeds.2022.01.012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pompano&issn=0022-3476&title=Journal+of+Pediatrics&atitle=Adjusting+Ferritin+Concentrations+for+Nonclinical+Inflammation+in+Adolescents+with+Overweight+or+Obesity.&volume=244&issue=&spage=125&epage=132.e1&date=2022&doi=10.1016%2Fj.jpeds.2022.01.012&pmid=35074310&sid=OVID:medline
+
+<581>
+Unique Identifier
+ 35073832
+Title
+ No association of BMI and body adiposity with cardiometabolic biomarkers among a small sample of reindeer herders of sub-Arctic Finland.
+Source
+ International Journal of Circumpolar Health. 81(1):2024960, 2022 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ocobock C; Soppela P; Turunen MT
+Authors Full Name
+ Ocobock, Cara; Soppela, Paivi; Turunen, Minna T.
+Institution
+ Ocobock, Cara. Department of Anthropology, University of Notre Dame, Notre Dame, IN, USA.
+ Ocobock, Cara. Eck Institute for Global Health, Institute for Educational Initiatives, University of Notre Dame, Notre Dame, IN, USA.
+ Soppela, Paivi. Arctic Centre, University of Lapland, Rovaniemi, Finland.
+ Turunen, Minna T. Arctic Centre, University of Lapland, Rovaniemi, Finland.
+MeSH Subject Headings
+ Adiposity
+ Animals
+ Biomarkers
+ Body Mass Index
+ *Cardiovascular Diseases
+ Cholesterol
+ Finland/ep [Epidemiology]
+ Humans
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ *Reindeer
+ Risk Factors
+Keyword Heading
+ Body mass index
+ body adiposity
+ cardiometabolic health
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The rising global obesity rate is alarming due to its real health and socioeconomic consequences. Finland, like other circumpolar regions, is also experiencing a rise in obesity . Here we assess BMI, body adiposity, and measures of cardiometabolic health among a small population of reindeer herders in sub-Arctic Finland. We collected anthropometric and biomarker measures at two different time points: October 2018 (N = 20) and January 2019 (N = 21) with a total of 25 unique individuals across the data collection periods (ages 20-64). Anthropometric measures included height, weight, age, and body composition. Biomarkers included measures of cholesterol, fasting glucose, HDL cholesterol, LDL cholesterol, and triglyceride levels. Over 70% of this sample was classified as "overweight" and "obese" as categorised by BMI and 64% classified as "overfat" based on body fat percentage. However, there was no significant relationship between BMI and body fat percentage with any of the measured biomarkers. Although the sample size is small, the results of this study suggest there might not be a strong correlation between BMI, body adiposity, and cardiometabolic health indices within this population - a pattern that has been documented elsewhere. However, further study is needed to confirm this lack of a correlation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f22423982.2021.2024960
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ocobock&issn=1239-9736&title=International+Journal+of+Circumpolar+Health&atitle=No+association+of+BMI+and+body+adiposity+with+cardiometabolic+biomarkers+among+a+small+sample+of+reindeer+herders+of+sub-Arctic+Finland.&volume=81&issue=1&spage=2024960&epage=&date=2022&doi=10.1080%2F22423982.2021.2024960&pmid=35073832&sid=OVID:medline
+
+<582>
+Unique Identifier
+ 35062859
+Title
+ Long noncoding RNA XIST regulates brown preadipocytes differentiation and combats high-fat diet induced obesity by targeting C/EBPalpha.
+Source
+ Molecular Medicine. 28(1):6, 2022 01 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu C; Fang S; Zhang H; Li X; Du Y; Zhang Y; Lin X; Wang L; Ma X; Xue Y; Guan M
+Author NameID
+ Guan, Meiping; ORCID: https://orcid.org/0000-0002-9709-9320
+Authors Full Name
+ Wu, Chunyan; Fang, Shu; Zhang, Huijian; Li, Xiaoqiang; Du, Yuejun; Zhang, Yudan; Lin, Xiaochun; Wang, Ling; Ma, Xiaoqin; Xue, Yaoming; Guan, Meiping.
+Institution
+ Wu, Chunyan. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Wu, Chunyan. Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510515, China.
+ Fang, Shu. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Zhang, Huijian. Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Li, Xiaoqiang. Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Du, Yuejun. Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Zhang, Yudan. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Lin, Xiaochun. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Wang, Ling. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Ma, Xiaoqin. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Xue, Yaoming. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
+ Guan, Meiping. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. mpguan@163.com.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ *Adipocytes/me [Metabolism]
+ *Adipose Tissue, Brown/cy [Cytology]
+ *Adipose Tissue, Brown/me [Metabolism]
+ Animals
+ Biomarkers
+ *CCAAT-Enhancer-Binding Proteins/ge [Genetics]
+ Cell Differentiation
+ Diet, High-Fat
+ Disease Models, Animal
+ Disease Susceptibility
+ Gene Expression Regulation
+ Immunophenotyping
+ Male
+ Mice
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ RNA Interference
+ *RNA, Long Noncoding/ge [Genetics]
+Keyword Heading
+ Adipose tissue
+ Brown preadipocyte
+ Obesity
+ XIST
+ lncRNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Activation of brown adipose tissue (BAT) increases energy expenditure, which makes it an attractive therapeutic strategy for obesity. LncRNAs play an important role in adipocyte differentiation and regulation. Here we assessed the effect of lncRNA XIST on brown preadipocytes differentiation and metabolic regulation.
+
+ METHODS: XIST expression levels were detected in human perirenal (peri-N) and subcutaneous adipose tissues (sub-Q), brown preadipocytes and 3T3-L1 preadipocytes. XIST overexpression and knockdown experiments were performed in brown preadipocytes. XIST overexpression mouse model was established by plasmid injection through tail vein.
+
+ RESULTS: In human adipose tissues, XIST expression was significantly higher in female than in male individuals. In vitro, XIST expression was significantly up-regulated during brown adipocyte differentiation. XIST knockdown inhibited differentiation of brown preadipocytes, while overexpression of XIST promotes brown preadipocytes to fully differentiation. RNA Binding Protein Immunoprecipitation (RIP) experiment revealed that XIST could directly bind to C/EBPalpha. In vivo, XIST overexpression prevents high-fat diet induced obesity and improves metabolic dysorder in male mice.
+
+ CONCLUSION: Our results suggest that XIST combats obesity through BAT activation at least partly by combination with transcription factor C/EBPalpha. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CCAAT-Enhancer-Binding Proteins). 0 (CEBPA protein, mouse). 0 (RNA, Long Noncoding). 0 (XIST non-coding RNA).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1186%2fs10020-022-00434-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=1076-1551&title=Molecular+Medicine&atitle=Long+noncoding+RNA+XIST+regulates+brown+preadipocytes+differentiation+and+combats+high-fat+diet+induced+obesity+by+targeting+C%2FEBPalpha.&volume=28&issue=1&spage=6&epage=&date=2022&doi=10.1186%2Fs10020-022-00434-3&pmid=35062859&sid=OVID:medline
+
+<583>
+Unique Identifier
+ 35057555
+Title
+ Whole Grain Consumption and Inflammatory Markers: A Systematic Literature Review of Randomized Control Trials.
+Source
+ Nutrients. 14(2), 2022 Jan 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Milesi G; Rangan A; Grafenauer S
+Author NameID
+ Rangan, Anna; ORCID: https://orcid.org/0000-0003-1815-844X
+Authors Full Name
+ Milesi, Genevieve; Rangan, Anna; Grafenauer, Sara.
+Institution
+ Milesi, Genevieve. Nutrition and Dietetics Group, Sydney Nursing School, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.
+ Rangan, Anna. Nutrition and Dietetics Group, Sydney Nursing School, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.
+ Grafenauer, Sara. Grains & Legumes Nutrition Council, Mount Street, North Sydney, NSW 2060, Australia.
+ Grafenauer, Sara. School of Medicine & Health, University of New South Wales, Randwick, NSW 2052, Australia.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Bias
+ Biomarkers/bl [Blood]
+ *C-Reactive Protein/an [Analysis]
+ Humans
+ Inflammation
+ Inflammation Mediators/bl [Blood]
+ *Interleukin-6/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Overweight/bl [Blood]
+ Randomized Controlled Trials as Topic
+ *Tumor Necrosis Factor-alpha/bl [Blood]
+ *Whole Grains
+ Young Adult
+Keyword Heading
+ C-reactive protein
+ inflammation
+ inflammatory markers
+ interlukin-6
+ refined grain
+ tumor necrosis factor
+ whole grain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Whole grain foods are rich in nutrients, dietary fibre, a range of antioxidants, and phytochemicals, and may have potential to act in an anti-inflammatory manner, which could help impact chronic disease risk. This systematic literature review aimed to examine the specific effects of whole grains on selected inflammatory markers from human clinical trials in adults. As per the Preferred Reporting Items for Systematic Reviews (PRISMA) protocol, the online databases MEDLINE, Embase, Cochrane, CINAHL, and Scopus were searched from inception through to 31 August 2021. Randomized control trials (RCTs) >= 4 weeks in duration, reporting >=1 of the following: C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor (TNF), were included. A total of 31 RCTs were included, of which 16 studies recruited overweight/obese individuals, 12 had pre-existing conditions, two were in a healthy population, and one study included participants with prostate cancer. Of these 31 RCTs, three included studies with two intervention arms. A total of 32 individual studies measured CRP (10/32 were significant), 18 individual studies measured IL-6 (2/18 were significant), and 13 individual studies measured TNF (5/13 were significant). Most often, the overweight/obese population and those with pre-existing conditions showed significant reductions in inflammatory markers, mainly CRP (34% of studies). Overall, consumption of whole grain foods had a significant effect in reducing at least one inflammatory marker as demonstrated in 12/31 RCTs.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fnu14020374
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Milesi&issn=2072-6643&title=Nutrients&atitle=Whole+Grain+Consumption+and+Inflammatory+Markers%3A+A+Systematic+Literature+Review+of+Randomized+Control+Trials.&volume=14&issue=2&spage=&epage=&date=2022&doi=10.3390%2Fnu14020374&pmid=35057555&sid=OVID:medline
+
+<584>
+Unique Identifier
+ 35057554
+Title
+ Application of a Machine Learning Technology in the Definition of Metabolically Healthy and Unhealthy Status: A Retrospective Study of 2567 Subjects Suffering from Obesity with or without Metabolic Syndrome.
+Source
+ Nutrients. 14(2), 2022 Jan 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Masi D; Risi R; Biagi F; Vasquez Barahona D; Watanabe M; Zilich R; Gabrielli G; Santin P; Mariani S; Lubrano C; Gnessi L
+Author NameID
+ Risi, Renata; ORCID: https://orcid.org/0000-0003-2905-4398
+ Watanabe, Mikiko; ORCID: https://orcid.org/0000-0003-2225-8814
+ Mariani, Stefania; ORCID: https://orcid.org/0000-0003-1762-4701
+ Lubrano, Carla; ORCID: https://orcid.org/0000-0001-8261-1451
+Authors Full Name
+ Masi, Davide; Risi, Renata; Biagi, Filippo; Vasquez Barahona, Daniel; Watanabe, Mikiko; Zilich, Rita; Gabrielli, Gabriele; Santin, Pierluigi; Mariani, Stefania; Lubrano, Carla; Gnessi, Lucio.
+Institution
+ Masi, Davide. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Risi, Renata. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Risi, Renata. MRC Metabolic Diseases Unit, MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 1TN, UK.
+ Biagi, Filippo. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Vasquez Barahona, Daniel. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Watanabe, Mikiko. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Zilich, Rita. Mix-x Partner, 20153 Milano, Italy.
+ Gabrielli, Gabriele. Rulex Inc., 16122 Genova, Italy.
+ Santin, Pierluigi. Deimos Engineering, 33100 Udine, Italy.
+ Mariani, Stefania. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Lubrano, Carla. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Gnessi, Lucio. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+MeSH Subject Headings
+ Absorptiometry, Photon/mt [Methods]
+ Adipose Tissue/me [Metabolism]
+ Adult
+ Alanine Transaminase/bl [Blood]
+ Artificial Intelligence
+ Biomarkers/bl [Blood]
+ Female
+ Glycated Hemoglobin/an [Analysis]
+ Health Status
+ Humans
+ Insulin-Like Growth Factor I/an [Analysis]
+ *Machine Learning
+ Male
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity, Metabolically Benign/di [Diagnosis]
+ Obesity, Metabolically Benign/ep [Epidemiology]
+ Prognosis
+ Retrospective Studies
+ Risk Factors
+Keyword Heading
+ artificial intelligence
+ insulin-like growth factor 1
+ metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The key factors playing a role in the pathogenesis of metabolic alterations observed in many patients with obesity have not been fully characterized. Their identification is crucial, and it would represent a fundamental step towards better management of this urgent public health issue. This aim could be accomplished by exploiting the potential of machine learning (ML) technology. In a single-centre study (n = 2567), we used an ML analysis to cluster patients with metabolically healthy (MHO) or metabolically unhealthy (MUO) obesity, based on several clinical and biochemical variables. The first model provided by ML was able to predict the presence/absence of MHO with an accuracy of 66.67% and 72.15%, respectively, and included the following parameters: HOMA-IR, upper body fat/lower body fat, glycosylated haemoglobin, red blood cells, age, alanine aminotransferase, uric acid, white blood cells, insulin-like growth factor 1 (IGF-1) and gamma-glutamyl transferase. For each of these parameters, ML provided threshold values identifying either MUO or MHO. A second model including IGF-1 zSDS, a surrogate marker of IGF-1 normalized by age and sex, was even more accurate with a 71.84% and 72.3% precision, respectively. Our results demonstrated high IGF-1 levels in MHO patients, thus highlighting a possible role of IGF-1 as a novel metabolic health parameter to effectively predict the development of MUO using ML technology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 67763-96-6 (Insulin-Like Growth Factor I). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fnu14020373
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Masi&issn=2072-6643&title=Nutrients&atitle=Application+of+a+Machine+Learning+Technology+in+the+Definition+of+Metabolically+Healthy+and+Unhealthy+Status%3A+A+Retrospective+Study+of+2567+Subjects+Suffering+from+Obesity+with+or+without+Metabolic+Syndrome.&volume=14&issue=2&spage=&epage=&date=2022&doi=10.3390%2Fnu14020373&pmid=35057554&sid=OVID:medline
+
+<585>
+Unique Identifier
+ 35055038
+Title
+ Skeletal Muscle Microvascular Dysfunction in Obesity-Related Insulin Resistance: Pathophysiological Mechanisms and Therapeutic Perspectives. [Review]
+Source
+ International Journal of Molecular Sciences. 23(2), 2022 Jan 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ugwoke CK; Cvetko E; Umek N
+Author NameID
+ Ugwoke, Chiedozie Kenneth; ORCID: https://orcid.org/0000-0003-4143-369X
+ Umek, Nejc; ORCID: https://orcid.org/0000-0001-5831-2216
+Authors Full Name
+ Ugwoke, Chiedozie Kenneth; Cvetko, Erika; Umek, Nejc.
+Institution
+ Ugwoke, Chiedozie Kenneth. Institute of Anatomy, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
+ Cvetko, Erika. Institute of Anatomy, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
+ Umek, Nejc. Institute of Anatomy, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
+MeSH Subject Headings
+ Animals
+ Anti-Obesity Agents/pd [Pharmacology]
+ Anti-Obesity Agents/tu [Therapeutic Use]
+ Biomarkers
+ Disease Management
+ Disease Susceptibility
+ Endothelium, Vascular/me [Metabolism]
+ Energy Metabolism
+ Extracellular Matrix
+ Gene Expression Regulation
+ Homeostasis
+ Humans
+ Insulin/me [Metabolism]
+ *Insulin Resistance
+ *Microcirculation
+ Microvessels/de [Drug Effects]
+ Microvessels/me [Metabolism]
+ *Microvessels/pp [Physiopathology]
+ Molecular Targeted Therapy
+ *Muscle, Skeletal/bs [Blood Supply]
+ *Muscle, Skeletal/me [Metabolism]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/th [Therapy]
+ Oxidation-Reduction
+ Vascular Diseases/et [Etiology]
+ Vascular Diseases/me [Metabolism]
+Keyword Heading
+ insulin resistance
+ microvascular dysfunction
+ obesity
+ obesity treatment
+ skeletal muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a worrisomely escalating public health problem globally and one of the leading causes of morbidity and mortality from noncommunicable disease. The epidemiological link between obesity and a broad spectrum of cardiometabolic disorders has been well documented; however, the underlying pathophysiological mechanisms are only partially understood, and effective treatment options remain scarce. Given its critical role in glucose metabolism, skeletal muscle has increasingly become a focus of attention in understanding the mechanisms of impaired insulin function in obesity and the associated metabolic sequelae. We examined the current evidence on the relationship between microvascular dysfunction and insulin resistance in obesity. A growing body of evidence suggest an intimate and reciprocal relationship between skeletal muscle microvascular and glucometabolic physiology. The obesity phenotype is characterized by structural and functional changes in the skeletal muscle microcirculation which contribute to insulin dysfunction and disturbed glucose homeostasis. Several interconnected etiologic molecular mechanisms have been suggested, including endothelial dysfunction by several factors, extracellular matrix remodelling, and induction of oxidative stress and the immunoinflammatory phenotype. We further correlated currently available pharmacological agents that have deductive therapeutic relevance to the explored pathophysiological mechanisms, highlighting a potential clinical perspective in obesity treatment.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Insulin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fijms23020847
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ugwoke&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Skeletal+Muscle+Microvascular+Dysfunction+in+Obesity-Related+Insulin+Resistance%3A+Pathophysiological+Mechanisms+and+Therapeutic+Perspectives.&volume=23&issue=2&spage=847&epage=&date=2022&doi=10.3390%2Fijms23020847&pmid=35055038&sid=OVID:medline
+
+<586>
+Unique Identifier
+ 35055005
+Title
+ Dosing Therapeutic Radiopharmaceuticals in Obese Patients. [Review]
+Source
+ International Journal of Molecular Sciences. 23(2), 2022 Jan 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van Nuland M; Ververs TF; Lam MGEH
+Author NameID
+ van Nuland, Merel; ORCID: https://orcid.org/0000-0003-1763-7334
+ Ververs, Tessa F; ORCID: https://orcid.org/0000-0001-9467-023X
+Authors Full Name
+ van Nuland, Merel; Ververs, Tessa F; Lam, Marnix G E H.
+Institution
+ van Nuland, Merel. Department of Clinical Pharmacy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
+ Ververs, Tessa F. Department of Clinical Pharmacy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
+ Ververs, Tessa F. Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
+ Lam, Marnix G E H. Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
+MeSH Subject Headings
+ Biomarkers
+ Clinical Decision-Making
+ Disease Management
+ Drug Monitoring
+ Humans
+ Molecular Targeted Therapy
+ Obesity/di [Diagnosis]
+ Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ Organ Specificity/de [Drug Effects]
+ Prognosis
+ *Radiopharmaceuticals/ad [Administration & Dosage]
+ Radiopharmaceuticals/ch [Chemistry]
+ Radiopharmaceuticals/pd [Pharmacology]
+ Radiopharmaceuticals/tu [Therapeutic Use]
+ Treatment Outcome
+Keyword Heading
+ obesity
+ pharmacokinetics
+ radiopharmaceutical
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The prevalence of obesity has increased dramatically in the Western population. Obesity is known to influence not only the proportion of adipose tissue but also physiological processes that could alter drug pharmacokinetics. Yet, there are no specific dosing recommendations for radiopharmaceuticals in this patient population. This could potentially lead to underdosing and thus suboptimal treatment in obese patients, while it could also lead to drug toxicity due to high levels of radioactivity. In this review, relevant literature is summarized on radiopharmaceutical dosing and pharmacokinetic properties, and we aimed to translate these data into practical guidelines for dosing of radiopharmaceuticals in obese patients. For radium-223, dosing in obese patients is well established. Furthermore, for samarium-153-ethylenediaminetetramethylene (EDTMP), dose-escalation studies show that the maximum tolerated dose will probably not be reached in obese patients when dosing on MBq/kg. On the other hand, there is insufficient evidence to support dose recommendations in obese patients for rhenium-168-hydroxyethylidene diphosphonate (HEDP), sodium iodide-131, iodide 131-metaiodobenzylguanidine (MIBG), lutetium-177-dotatate, and lutetium-177-prostate-specific membrane antigen (PSMA). From a pharmacokinetic perspective, fixed dosing may be appropriate for these drugs. More research into obese patient populations is needed, especially in the light of increasing prevalence of obesity worldwide.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Radiopharmaceuticals).
+Publication Type
+ Journal Article. Meta-Analysis. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fijms23020818
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+Nuland&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Dosing+Therapeutic+Radiopharmaceuticals+in+Obese+Patients.&volume=23&issue=2&spage=818&epage=&date=2022&doi=10.3390%2Fijms23020818&pmid=35055005&sid=OVID:medline
+
+<587>
+Unique Identifier
+ 35054932
+Title
+ Kidney Damage Caused by Obesity and Its Feasible Treatment Drugs. [Review]
+Source
+ International Journal of Molecular Sciences. 23(2), 2022 Jan 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang M; Wang Z; Chen Y; Dong Y
+Author NameID
+ Wang, Meihui; ORCID: https://orcid.org/0000-0001-8345-8137
+ Chen, Yaoxing; ORCID: https://orcid.org/0000-0003-2576-5977
+Authors Full Name
+ Wang, Meihui; Wang, Zixu; Chen, Yaoxing; Dong, Yulan.
+Institution
+ Wang, Meihui. Neurobiology Laboratory, Department of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
+ Wang, Zixu. Neurobiology Laboratory, Department of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
+ Chen, Yaoxing. Neurobiology Laboratory, Department of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
+ Dong, Yulan. Neurobiology Laboratory, Department of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
+ Dong, Yulan. Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
+MeSH Subject Headings
+ Animals
+ *Biomarkers
+ Cytokines/me [Metabolism]
+ Disease Management
+ *Disease Susceptibility
+ *Drug Development
+ Humans
+ Inflammation Mediators
+ Insulin Resistance
+ Kidney Diseases/dt [Drug Therapy]
+ *Kidney Diseases/et [Etiology]
+ Kidney Diseases/me [Metabolism]
+ Kidney Glomerulus/me [Metabolism]
+ Kidney Glomerulus/pa [Pathology]
+ Kidney Tubules
+ Molecular Targeted Therapy/mt [Methods]
+ *Obesity/co [Complications]
+ Oxidative Stress
+ Renin-Angiotensin System
+Keyword Heading
+ inflammation
+ kidney damage
+ melatonin
+ obesity
+ oxidative stress
+ treatment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The rapid growth of obesity worldwide has made it a major health problem, while the dramatic increase in the prevalence of obesity has had a significant impact on the magnitude of chronic kidney disease (CKD), especially in developing countries. A vast amount of researchers have reported a strong relationship between obesity and chronic kidney disease, and obesity can serve as an independent risk factor for kidney disease. The histological changes of kidneys in obesity-induced renal injury include glomerular or tubular hypertrophy, focal segmental glomerulosclerosis or bulbous sclerosis. Furthermore, inflammation, renal hemodynamic changes, insulin resistance and lipid metabolism disorders are all involved in the development and progression of obesity-induced nephropathy. However, there is no targeted treatment for obesity-related kidney disease. In this review, RAS inhibitors, SGLT2 inhibitors and melatonin would be presented to treat obesity-induced kidney injury. Furthermore, we concluded that melatonin can protect the kidney damage caused by obesity by inhibiting inflammation and oxidative stress, revealing its therapeutic potential.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3390%2fijms23020747
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Kidney+Damage+Caused+by+Obesity+and+Its+Feasible+Treatment+Drugs.&volume=23&issue=2&spage=747&epage=&date=2022&doi=10.3390%2Fijms23020747&pmid=35054932&sid=OVID:medline
+
+<588>
+Unique Identifier
+ 35051962
+Title
+ Physical Activity, Sedentary Time, and Cardiometabolic Health in Heavy Goods Vehicle Drivers.
+Source
+ Journal of Occupational & Environmental Medicine. 64(4):e217-e223, 2022 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ruettger K; Varela-Mato V; Chen YL; Edwardson CL; Guest A; Gilson ND; Gray LJ; Paine NJ; Sherry AP; Sayyah M; Yates T; King JA; Clemes SA
+Authors Full Name
+ Ruettger, Katharina; Varela-Mato, Veronica; Chen, Yu-Ling; Edwardson, Charlotte L; Guest, Amber; Gilson, Nicholas D; Gray, Laura J; Paine, Nicola J; Sherry, Aron P; Sayyah, Mohsen; Yates, Thomas; King, James A; Clemes, Stacy A.
+Institution
+ Ruettger, Katharina. School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (Miss Ruettger, Dr Varela-Mato, Dr Chen, Miss Guest, Dr Paine, Dr Sherry, Dr Sayyah, Dr King, Dr Clemes), NIHR Leicester Biomedical Research Centre, United Kingdom (Dr Varela-Mato, Dr Edwardson, Dr Paine, Dr Sherry, Dr Yates, Dr King, Dr Clemes), Diabetes Research Centre, University of Leicester, United Kingdom (Dr Edwardson, Dr Yates), School of Human Movement and Nutrition Sciences, University of Queensland, Australia (Dr Gilson), Department of Health Sciences, University of Leicester, Leicester, United Kingdom (Dr Gray).
+MeSH Subject Headings
+ Biomarkers
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases
+ Cholesterol, LDL
+ Exercise
+ Humans
+ Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ Risk Factors
+ *Sedentary Behavior
+Abstract
+ OBJECTIVE: Physical inactivity, prolonged sitting, and unhealthy dietary habits are common in Heavy Goods Vehicle (HGV) drivers. These factors increase risk of long-term health conditions.
+
+ METHODS: 329 HGV drivers across 25 UK depots completed a health assessment, including questionnaire completion, and objectively measured anthropometrics, blood biomarkers, physical activity (PA), and sedentary behavior.
+
+ RESULTS: The sample demonstrated a high-risk cardiometabolic health profile. 88.1% were overweight or had obesity, and 11.9% had pre-diabetes or diabetes. 28.3% had hypertension, 83.6% had clinically elevated circulating low-density lipoprotein-cholesterol concentrations (>2mmol/l), and 66.6% had high total cholesterol levels (>4mmol/l). On workdays drivers accumulated 12 hours/day of sitting, 1.7 hours/day of light PA, and 9.8 mins/day of moderate-to-vigorous PA. Associations between light PA and cardiometabolic markers were observed.
+
+ CONCLUSION: This sample presents high levels of inactivity, overweight, and obesity, and unhealthy cardiometabolic health profiles. Copyright © 2022 American College of Occupational and Environmental Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1097%2fJOM.0000000000002484
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ruettger&issn=1076-2752&title=Journal+of+Occupational+%26+Environmental+Medicine&atitle=Physical+Activity%2C+Sedentary+Time%2C+and+Cardiometabolic+Health+in+Heavy+Goods+Vehicle+Drivers.&volume=64&issue=4&spage=e217&epage=e223&date=2022&doi=10.1097%2FJOM.0000000000002484&pmid=35051962&sid=OVID:medline
+
+<589>
+Unique Identifier
+ 35051942
+Title
+ MicroRNAs in Obesity-Associated Disorders: The Role of Exercise Training. [Review]
+Source
+ Obesity Facts. 15(2):105-117, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Silveira A; Gomes J; Roque F; Fernandes T; de Oliveira EM
+Authors Full Name
+ Silveira, Andre; Gomes, Joao; Roque, Fernanda; Fernandes, Tiago; de Oliveira, Edilamar Menezes.
+Institution
+ Silveira, Andre. Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
+ Silveira, Andre. Endurance Performance Research Group (GEDAE-USP), School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
+ Gomes, Joao. Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
+ Roque, Fernanda. Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
+ Fernandes, Tiago. Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
+ de Oliveira, Edilamar Menezes. Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
+MeSH Subject Headings
+ Biomarkers
+ Cardiovascular Diseases/ge [Genetics]
+ *Cardiovascular Diseases
+ Exercise/ph [Physiology]
+ Humans
+ MicroRNAs/ge [Genetics]
+ MicroRNAs/me [Metabolism]
+ *MicroRNAs
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Obesity/th [Therapy]
+Keyword Heading
+ Biomarker
+ Cardiac hypertrophy
+ Exercise training
+ MicroRNA
+ Microvascular rarefaction
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a worldwide epidemic affecting over 13% of the adult population and is defined by an excess of body fat that predisposes comorbidities. It is considered a multifactorial disease in which environmental and genetic factors interact, and it is a risk marker for cardiovascular disease. Lifestyle modifications remain the mainstay of treatment for obesity based on adequate diet and physical exercise. In addition, obesity is related to cardiovascular and skeletal muscle disorders, such as cardiac hypertrophy, microvascular rarefaction, and skeletal muscle atrophy. The discovery of obesity-involved molecular pathways is an important step to improve both the prevention and management of this disease. MicroRNAs (miRNAs) are a class of gene regulators which bind most commonly, but not exclusively, to the 3'-untranslated regions of messenger RNAs of protein-coding genes and negatively regulate their expression. Considerable effort has been made to identify miRNAs and target genes that predispose to obesity. Besides their intracellular function, recent studies have demonstrated that miRNAs can be exported or released by cells and circulate within the blood in a remarkably stable form. The discovery of circulating miRNAs opens up intriguing possibilities for the use of circulating miRNA patterns as biomarkers for obesity and cardiovascular diseases. The aim of this review is to provide an overview of the recent discoveries of the role played by miRNAs in the obese phenotype and associated comorbidities. Furthermore, we will discuss the role of exercise training on regulating miRNAs, indicating the mechanisms related to these alterations. Copyright © 2022 The Author(s). Published by S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1159%2f000517849
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Silveira&issn=1662-4025&title=Obesity+Facts&atitle=MicroRNAs+in+Obesity-Associated+Disorders%3A+The+Role+of+Exercise+Training.&volume=15&issue=2&spage=105&epage=117&date=2022&doi=10.1159%2F000517849&pmid=35051942&sid=OVID:medline
+
+<590>
+Unique Identifier
+ 35038337
+Title
+ Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 107(6):e2619-e2627, 2022 05 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ramirez-Velez R; Garcia-Hermoso A; Correa-Rodriguez M; Fernandez-Irigoyen J; Palomino-Echeverria S; Santamaria E; Correa-Bautista JE; Gonzalez-Ruiz K; Izquierdo M
+Author NameID
+ Ramirez-Velez, Robinson; ORCID: https://orcid.org/0000-0003-3075-6960
+ Garcia-Hermoso, Antonio; ORCID: https://orcid.org/0000-0002-1397-7182
+ Correa-Rodriguez, Maria; ORCID: https://orcid.org/0000-0001-9165-4349
+ Fernandez-Irigoyen, Joaquin; ORCID: https://orcid.org/0000-0001-5072-4099
+ Palomino-Echeverria, Sara; ORCID: https://orcid.org/0000-0002-0451-3749
+ Santamaria, Enrique; ORCID: https://orcid.org/0000-0001-8046-8102
+ Correa-Bautista, Jorge Enrique; ORCID: https://orcid.org/0000-0002-0646-2316
+ Gonzalez-Ruiz, Katherine; ORCID: https://orcid.org/0000-0001-7518-0761
+ Izquierdo, Mikel; ORCID: https://orcid.org/0000-0002-1506-4272
+Authors Full Name
+ Ramirez-Velez, Robinson; Garcia-Hermoso, Antonio; Correa-Rodriguez, Maria; Fernandez-Irigoyen, Joaquin; Palomino-Echeverria, Sara; Santamaria, Enrique; Correa-Bautista, Jorge Enrique; Gonzalez-Ruiz, Katherine; Izquierdo, Mikel.
+Institution
+ Ramirez-Velez, Robinson. Navarrabiomed, Hospital Universitario de Navarra (HUN), Navarra Institute for Health Research (IdiSNA), Universidad Publica de Navarra (UPNA), 31008 Pamplona, Spain.
+ Ramirez-Velez, Robinson. Centro de Investigacion Biomedica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Garcia-Hermoso, Antonio. Navarrabiomed, Hospital Universitario de Navarra (HUN), Navarra Institute for Health Research (IdiSNA), Universidad Publica de Navarra (UPNA), 31008 Pamplona, Spain.
+ Garcia-Hermoso, Antonio. Escuela de Ciencias de la Actividad Fisica, el Deporte y la Salud, Facultad de Ciencias Medicas, Universidad de Santiago de Chile, USACH, Santiago 9170022, Chile.
+ Correa-Rodriguez, Maria. Department of Nursing, Faculty of Health Sciences, University of Granada, 18016 Granada, Spain.
+ Correa-Rodriguez, Maria. Biosanitary Research Institute (ibs.GRANADA), Granada, Spain.
+ Fernandez-Irigoyen, Joaquin. Proteored-Institute of Health Carlos III (ISCIII), Clinical Neuroproteomics Unit, Navarrabiomed, Navarra Health Department, Public University of Navarra, Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
+ Palomino-Echeverria, Sara. Translational Bioinformatics Unit (TransBio), Navarrabiomed, Navarra Health Department, Public University of Navarra, Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
+ Santamaria, Enrique. Proteored-Institute of Health Carlos III (ISCIII), Clinical Neuroproteomics Unit, Navarrabiomed, Navarra Health Department, Public University of Navarra, Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
+ Correa-Bautista, Jorge Enrique. Grupo Rendimiento Fisico Militar "RENFIMIL", Escuela Militar de Cadetes "General Jose Maria Cordova", Bogota, 111711, Colombia.
+ Gonzalez-Ruiz, Katherine. Grupo de Investigacion Salud y Movimiento. Programa de Fisioterapia. Facultad de Salud, Universidad Santiago de Cali, 760035, Colombia.
+ Gonzalez-Ruiz, Katherine. Programa de Doctorado en Ciencias Biomedicas y Biologicas, Escuela de Medicina y Ciencias de la Salud - Facultad de Ciencias Naturales y Matematicas, Universidad del Rosario, Bogota, 111221, Colombia.
+ Izquierdo, Mikel. Navarrabiomed, Hospital Universitario de Navarra (HUN), Navarra Institute for Health Research (IdiSNA), Universidad Publica de Navarra (UPNA), 31008 Pamplona, Spain.
+ Izquierdo, Mikel. Centro de Investigacion Biomedica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Body Mass Index
+ *Exercise
+ Female
+ Humans
+ Inflammation
+ Male
+ Obesity/th [Therapy]
+ *Obesity
+ Overweight/th [Therapy]
+ *Overweight
+Keyword Heading
+ exercise
+ inflammation
+ obesity
+ youth
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PROPOSE: Obesity-related metabolic risk factors in adolescents who are overweight/obese may be associated with systemic low-grade inflammation; therefore, we investigated whether 6 months of exercise training altered markers of inflammation.
+
+ METHODS: Secondary analyses of a randomized controlled exercise-based intervention trial (September 2017-December 2018). Adolescents aged 11 to 17 years (Tanner stage II-V), 70% girls, with a body mass index z-score at or above the 85th percentile, and/or with excess of adiposity (body fat >= 30%). The participants were randomly assigned to the following 4 groups for 6 months: (1) standard physical education lessons, as a control (CTRL); (2) high-intensity physical education class (HIPE); (3) low-to-moderate intensity physical education class (LIPE); (4) a combined group (PLUS). Inflammatory markers and immune molecules including chemokines, cytokines, and growth factors (n = 65 biomarkers) were determined by cytokine antibody array.
+
+ RESULTS: Of the 120 randomly assigned participants, 95 were included in the analysis. Considering these 22 proteins, the LIPE group shows statistical significance in 9 proteins with log-fold change (logFC) and P < 0.05 (in BLC, eotaxin, fibroblast growth factor-6 [FGF-6], GCP-2, I-309, IGFBP-4, MCP-4, NAP-2, and PARC), followed by the PLUS group in 9 proteins (BLC, pro-epidermal growth factor, eotaxin, FGF-6, MCP-4, NAP-2, osteopontin, PARC, and RANTES), the HIPE group in 7 proteins (FGF-4, FGF-7, GCP-2, IGF-1, IGFBP-1, IGFBP-4, and MIP-1 delta), and the CTRL group in 6 proteins (FGF-4, IP-10, Leptin, MCP-1, MIG, and MIP-1 delta). However, subanalysis performed to detect differentially expressed proteins at baseline and after intervention, with significance at an adjusted P value <= 0.05 and absolute log fold-change (logFC) >= 1.0, showed 3 downregulated proteins in the LIPE group (BLC(logFC) = 1.27, eotaxin(logFC) = 1.18, and MCP-4(logFC) = 1.14), and 4 proteins in the HIPE group (BLC(logFC) = 1.45, FGF-6(logFC) = 1.20, MCP-4(logFC) = 1.50, and PARC(logFC) = 1.33), supporting that the changes we observed in the exercise groups were not time-related changes but occurred in response to exercise.
+
+ CONCLUSIONS: Implementing a 6-month physical exercise program in overweight/obese adolescents, based on LIPE and PLUS groups, significantly change several circulating inflammatory levels. Interventions involving supervised physical exercise may reduce the associated effects of systemic low-grade inflammation, thus preventing the development of obesity-related metabolic diseases in adolescents with overweight/obesity. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1210%2fclinem%2fdgac021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ramirez-Velez&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Effects+of+Different+Doses+of+Exercise+on+Inflammation+Markers+Among+Adolescents+With+Overweight%2FObesity%3A+HEPAFIT+Study.&volume=107&issue=6&spage=e2619&epage=e2627&date=2022&doi=10.1210%2Fclinem%2Fdgac021&pmid=35038337&sid=OVID:medline
+
+<591>
+Unique Identifier
+ 35025088
+Title
+ Metabotyping for Precision Nutrition and Weight Management: Hype or Hope?. [Review]
+Source
+ Current Nutrition Reports. 11(2):117-123, 2022 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pigsborg K; Magkos F
+Author NameID
+ Pigsborg, Kristina; ORCID: https://orcid.org/0000-0003-1987-523X
+Authors Full Name
+ Pigsborg, Kristina; Magkos, Faidon.
+Institution
+ Pigsborg, Kristina. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958, Frederiksberg, Denmark. kpj@nexs.ku.dk.
+ Magkos, Faidon. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958, Frederiksberg, Denmark.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ *Diet
+ Humans
+ *Nutritional Status
+ Obesity
+Keyword Heading
+ Metabolomics
+ Obesity
+ Personalized nutrition
+ Precision nutrition
+ Weight management
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE OF REVIEW: Precision nutrition requires a solid understanding of the factors that determine individual responses to dietary treatment. We review the current state of knowledge in identifying human metabotypes - based on circulating biomarkers - that can predict weight loss or other relevant physiological outcomes in response to diet treatment.
+
+ RECENT FINDINGS: Not many studies have been conducted in this area and the ones identified here are heterogeneous in design and methodology, and therefore difficult to synthesize and draw conclusions. The basis of the creation of metabotypes varies widely, from using thresholds for a single metabolite to using complex algorithms to generate multi-component constructs that include metabolite and genetic information. Furthermore, available studies are a mix of hypothesis-driven and hypothesis-generating studies, and most of them lack experimental testing in human trials. Although this field of research is still in its infancy, precision-based dietary intervention strategies focusing on the metabotype group level hold promise for designing more effective dietary treatments for obesity. Copyright © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs13668-021-00392-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pigsborg&issn=2161-3311&title=Current+Nutrition+Reports&atitle=Metabotyping+for+Precision+Nutrition+and+Weight+Management%3A+Hype+or+Hope%3F.&volume=11&issue=2&spage=117&epage=123&date=2022&doi=10.1007%2Fs13668-021-00392-y&pmid=35025088&sid=OVID:medline
+
+<592>
+Unique Identifier
+ 35020917
+Title
+ Different Isocaloric Meals and Adiposity Modify Energy Expenditure and Clinical and Metabolomic Biomarkers During Resting and Exercise States in a Randomized Crossover Acute Trial of Normal-Weight and Overweight/Obese Men.
+Source
+ Journal of Nutrition. 152(4):1118-1129, 2022 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xiong Q; Sun L; Luo Y; Yun H; Shen X; Yin H; Chen X; Lin X
+Authors Full Name
+ Xiong, Quan; Sun, Liang; Luo, Yaogan; Yun, Huan; Shen, Xia; Yin, Huiyong; Chen, Xiafei; Lin, Xu.
+Institution
+ Xiong, Quan. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Sun, Liang. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Luo, Yaogan. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Yun, Huan. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Shen, Xia. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Shen, Xia. School of Life Science and Technology, Shanghai Tech University, Shanghai, China.
+ Yin, Huiyong. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Yin, Huiyong. School of Life Science and Technology, Shanghai Tech University, Shanghai, China.
+ Yin, Huiyong. Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China.
+ Chen, Xiafei. Huadong Hospital Affiliated with Fudan University, Shanghai, China.
+ Lin, Xu. Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Lin, Xu. Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, China.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ Adult
+ Biomarkers
+ Blood Glucose/me [Metabolism]
+ Cross-Over Studies
+ Energy Metabolism
+ Humans
+ Insulin
+ Male
+ Meals
+ Middle Aged
+ Obesity/me [Metabolism]
+ Overweight/me [Metabolism]
+ *Overweight
+ Postprandial Period/ph [Physiology]
+ Young Adult
+Keyword Heading
+ amino acids
+ energy expenditure
+ fat oxidation
+ macronutrients
+ untargeted metabolomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Few studies have assessed the integrative effects of diet, BMI, and exercise on postprandial changes in energy and circulating metabolic profiles.
+
+ OBJECTIVES: We aimed to assess the collective effects of 3 isocaloric meals high in carbohydrate (74.2% energy), fat (64.6% energy), or protein (39.5% energy) on energy expenditure and clinical and metabolomic biomarkers under resting and exercise conditions in normal-weight and overweight/obese men.
+
+ METHODS: This crossover controlled acute trial included 20 normal-weight (BMI, 18.5 to <24 kg/m2) and 20 overweight/obese (BMI >=24 kg/m2) men aged 18-45 years. Each of 3 test meals was provided for 2 continuous days: a resting day without exercise, followed by an exercise day with a bicycling exercise of 50% maximal oxygen consumption (postprandial 90-120 minutes). Energy expenditure (exploratory outcome of primary interest) was measured using indirect calorimetry. Fasting and postprandial 2-hour serum clinical and metabolomic biomarkers (secondary interest) were measured. Mixed models were used to examine the effects of meal, time, and/or BMI category.
+
+ RESULTS: On the resting day, no significant between-meal differences were detected for energy expenditure. However, high-carbohydrate and high-fat meals induced the highest postprandial 2-hour increase in glucose (0.34 +/- 0.15 mmol/L) and triglyceride (0.95 +/- 0.09 mmol/L), respectively, while the high-protein meal reduced glucose (-0.48 +/- 0.08 mmol/L) and total cholesterol (-0.01 +/- 0.03 mmol/L; all Pmeal values < 0.001). On the exercise day, a high-carbohydrate meal significantly promoted the carbohydrate oxidation rate but suppressed the fat oxidation rate (Pmeal < 0.05), while its postprandial glucose response was attenuated by bicycling (-0.31 +/- 0.03 mmol/L; Pexercise < 0.001). We identified 69 metabolites as key features in discriminating between the 3 meals, and overweight/obese men had more varieties of metabolites than normal-weight men.
+
+ CONCLUSIONS: Three isocaloric meals induced unique postprandial changes in clinical and metabolomic biomarkers, while exercise prevented the hyperglycemia induced by a high-carbohydrate meal. Overweight/obese men were more responsive to the meal challenges than normal-weight men. This trial was registered at clinicaltrials.gov as NCT03231618. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1093%2fjn%2fnxac006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xiong&issn=0022-3166&title=Journal+of+Nutrition&atitle=Different+Isocaloric+Meals+and+Adiposity+Modify+Energy+Expenditure+and+Clinical+and+Metabolomic+Biomarkers+During+Resting+and+Exercise+States+in+a+Randomized+Crossover+Acute+Trial+of+Normal-Weight+and+Overweight%2FObese+Men.&volume=152&issue=4&spage=1118&epage=1129&date=2022&doi=10.1093%2Fjn%2Fnxac006&pmid=35020917&sid=OVID:medline
+
+<593>
+Unique Identifier
+ 35020179
+Title
+ Muscular Fitness and Cardiometabolic Variables in Children and Adolescents: A Systematic Review.
+Source
+ Sports Medicine. 52(7):1555-1575, 2022 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Lima TR; Martins PC; Moreno YMF; Chaput JP; Tremblay MS; Sui X; Silva DAS
+Author NameID
+ de Lima, Tiago Rodrigues; ORCID: http://orcid.org/0000-0003-4568-2255
+ Martins, Priscila Custodio; ORCID: http://orcid.org/0000-0002-6388-5550
+ Moreno, Yara Maria Franco; ORCID: http://orcid.org/0000-0002-4983-2911
+ Chaput, Jean-Philippe; ORCID: http://orcid.org/0000-0002-5607-5736
+ Sui, Xuemei; ORCID: http://orcid.org/0000-0003-2368-7311
+ Silva, Diego Augusto Santos; ORCID: http://orcid.org/0000-0002-0489-7906
+Authors Full Name
+ de Lima, Tiago Rodrigues; Martins, Priscila Custodio; Moreno, Yara Maria Franco; Chaput, Jean-Philippe; Tremblay, Mark Stephen; Sui, Xuemei; Silva, Diego Augusto Santos.
+Institution
+ de Lima, Tiago Rodrigues. Research Center in Kinanthropometry and Human Performance, Sports Center, Federal University of Santa Catarina, University Campus, Trindade, Florianopolis, Santa Catarina, 88010-970, Brazil. tiagopersonaltrainer@gmail.com.
+ Martins, Priscila Custodio. Research Center in Kinanthropometry and Human Performance, Sports Center, Federal University of Santa Catarina, University Campus, Trindade, Florianopolis, Santa Catarina, 88010-970, Brazil.
+ Moreno, Yara Maria Franco. Department of Nutrition, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
+ Chaput, Jean-Philippe. Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
+ Tremblay, Mark Stephen. Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
+ Sui, Xuemei. Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
+ Silva, Diego Augusto Santos. Research Center in Kinanthropometry and Human Performance, Sports Center, Federal University of Santa Catarina, University Campus, Trindade, Florianopolis, Santa Catarina, 88010-970, Brazil.
+MeSH Subject Headings
+ Activities of Daily Living
+ Adolescent
+ Biomarkers
+ *Cardiovascular Diseases
+ Cross-Sectional Studies
+ Glucose
+ Humans
+ Lipids
+ Obesity
+ Physical Fitness/ph [Physiology]
+ *Physical Fitness
+ Risk Factors
+Abstract
+ BACKGROUND: The importance of muscular fitness (MF) in the performance of activities of daily living is unequivocal. Additionally, emerging evidence has shown MF can reduce cardiometabolic risk in children and adolescents.
+
+ OBJECTIVES: The purpose of this study was to examine and summarize the evidence regarding the relationship between MF phenotypes (i.e., maximum muscular strength/power, muscular endurance, and maximum muscular strength/power/endurance) and cardiometabolic variables (obesity, blood pressure, lipids, glucose homeostasis, inflammatory markers, and clustered cardiometabolic variables) in children and adolescents.
+
+ DESIGN: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and was registered with PROSPERO, number CRD42020179273.
+
+ DATA SOURCES: A systematic review was performed on five databases (PubMed, EMBASE, SciELO, Scopus, and Web of Knowledge) from database inception to May 2020, with complementary searches in reference lists.
+
+ ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Eligibility criteria included (1) a study sample of youth aged <= 19 years, (2) an assessment of MF with individual or clustered cardiometabolic variables derived from adjusted models (regardless of test/measurement adopted or direction of reported association), and (3) a report of the association between both, using observational studies. Only original articles published in peer-reviewed journals in English, Portuguese, and Spanish languages were considered. The quality of the included studies was assessed by using the National Heart, Lung, and Blood Institute checklist. The percentage of results reporting a statistically significant inverse association between each MF phenotype and cardiometabolic variables was calculated.
+
+ RESULTS: Of the 23,686 articles initially identified, 96 were included (77 cross-sectional and 19 longitudinal), with data from children and adolescents from 35 countries. The score for the quality of evidence ranged from 0.33 to 0.92 (1.00 maximum). MF assessed by maximum muscular strength/power was inversely associated with lower obesity (64/113 total results (56.6%)) and reduction in clustered cardiometabolic risk (28/48 total results (58.3%)). When assessed by muscular endurance, an inverse association with obesity (30/44 total results (68.1%)) and cardiometabolic risk (5/8 total results (62.5%)) was identified. Most of the results for the relationship between MF phenotypes with blood pressure, lipids, glucose homeostasis, and inflammatory markers indicated a paucity of evidence for these interrelationships (percentage of results below 50.0%).
+
+ CONCLUSION: MF assessed by maximum muscular strength/power or muscular endurance is potentially associated with lower obesity and lower risk related to clustered cardiometabolic variables in children and adolescents. There is limited support for an inverse association between MF with blood pressure, lipids, glucose homeostasis biomarkers, and inflammatory markers in children and adolescents. Copyright © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). IY9XDZ35W2 (Glucose).
+Publication Type
+ Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs40279-021-01631-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Lima&issn=0112-1642&title=Sports+Medicine&atitle=Muscular+Fitness+and+Cardiometabolic+Variables+in+Children+and+Adolescents%3A+A+Systematic+Review.&volume=52&issue=7&spage=1555&epage=1575&date=2022&doi=10.1007%2Fs40279-021-01631-6&pmid=35020179&sid=OVID:medline
+
+<594>
+Unique Identifier
+ 35013909
+Title
+ Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction.
+Source
+ GeroScience. 44(2):983-995, 2022 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Justice JN; Pajewski NM; Espeland MA; Brubaker P; Houston DK; Marcovina S; Nicklas BJ; Kritchevsky SB; Kitzman DW
+Authors Full Name
+ Justice, Jamie N; Pajewski, Nicholas M; Espeland, Mark A; Brubaker, Peter; Houston, Denise K; Marcovina, Santica; Nicklas, Barbara J; Kritchevsky, Stephen B; Kitzman, Dalane W.
+Institution
+ Justice, Jamie N. Department of Internal Medicine, Section On Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. jnjustic@wakehealth.edu.
+ Pajewski, Nicholas M. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+ Espeland, Mark A. Department of Internal Medicine, Section On Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+ Brubaker, Peter. Department of Health and Exercise Science at Wake, Forest University in Winston-Salem, NC, USA.
+ Houston, Denise K. Department of Internal Medicine, Section On Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+ Marcovina, Santica. Medpace Reference Laboratories, Cincinnati, OH, USA.
+ Nicklas, Barbara J. Department of Internal Medicine, Section On Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+ Kritchevsky, Stephen B. Department of Internal Medicine, Section On Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+ Kitzman, Dalane W. Department of Internal Medicine, Section On Cardiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Caloric Restriction
+ Exercise
+ Female
+ Geroscience
+ Heart Failure/dt [Drug Therapy]
+ *Heart Failure
+ Humans
+ Male
+ Obesity
+ Stroke Volume
+Keyword Heading
+ Aging
+ Cardiac
+ Diet
+ Intervention
+ Physical performance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Intermediate endpoints are needed to evaluate the effect of interventions targeting the biology of aging in clinical trials. A working group identified five blood-based biomarkers that may serve such a purpose as an integrated index. We evaluated the responsiveness of the panel to caloric restriction or aerobic exercise in the context of a randomized clinical trial conducted in patients with heart failure with preserved ejection fraction (HFpEF) with obese phenotype who were predominantly female. Obese HFpEF is highly prevalent in women, and is a geriatric syndrome whose disease pathology is driven by non-cardiac factors and shared drivers of aging. We measured serum Interleukin-6, TNF-alpha-receptor-I, growth differentiating factor-15, cystatin C, and N-terminal pro-b-type natriuretic peptide at baseline and after 20 weeks in older participants with stable obese HFpEF participating in a randomized, controlled, 2 x 2 factorial trial of caloric restriction and/or aerobic exercise. We calculated a composite biomarker index, summing baseline quintile scores for each biomarker, and analyzed the effect of the interventions on the index and individual biomarkers and their associations with changes in physical performance. This post hoc analysis included 88 randomized participants (71 women [81%]). The mean +/- SD age was 66.6 +/- 5.3 years, and body mass index (BMI) was 39.3 +/- 6.3 kg/m2. Using mixed models, mean values of the biomarker index improved over 20 weeks with caloric restriction (- 0.82 [Formula: see text] 0.58 points, p = 0.05), but not with exercise (- 0.28 [Formula: see text] 0.59 points, p = [Formula: see text]), with no evidence of an interaction effect of CR [Formula: see text] EX [Formula: see text] time (p = 0.80) with adjustment for age, gender, and BMI. At baseline, the biomarker index was inversely correlated with 6-min walk distance, scores on the short physical performance battery, treadmill test peak workload and exercise time to exhaustion (all [Formula: see text] s = between - 0.21 and - 0.24). A reduction in the biomarker index was also associated with increased 4-m usual walk speed ([Formula: see text] s = - 0.31). Among older patients with chronic obese HFpEF, caloric restriction improved a biomarker index designed to reflect biological aging. Moreover, the index was associated with physical performance and exercise tolerance. Copyright © 2022. The Author(s), under exclusive licence to American Aging Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs11357-021-00509-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Justice&issn=2509-2723&title=GeroScience&atitle=Evaluation+of+a+blood-based+geroscience+biomarker+index+in+a+randomized+trial+of+caloric+restriction+and+exercise+in+older+adults+with+heart+failure+with+preserved+ejection+fraction.&volume=44&issue=2&spage=983&epage=995&date=2022&doi=10.1007%2Fs11357-021-00509-9&pmid=35013909&sid=OVID:medline
+
+<595>
+Unique Identifier
+ 35013596
+Title
+ Association of metabolic dysfunction-associated fatty liver disease with kidney disease. [Review]
+Source
+ Nature Reviews Nephrology. 18(4):259-268, 2022 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang TY; Wang RF; Bu ZY; Targher G; Byrne CD; Sun DQ; Zheng MH
+Author NameID
+ Wang, Ting-Yao; ORCID: http://orcid.org/0000-0002-9458-1410
+ Wang, Rui-Fang; ORCID: http://orcid.org/0000-0002-5583-4753
+ Bu, Zhi-Ying; ORCID: http://orcid.org/0000-0001-7128-3376
+ Targher, Giovanni; ORCID: http://orcid.org/0000-0002-4325-3900
+ Byrne, Christopher D; ORCID: http://orcid.org/0000-0001-6322-7753
+ Sun, Dan-Qin; ORCID: http://orcid.org/0000-0002-8704-3606
+ Zheng, Ming-Hua; ORCID: http://orcid.org/0000-0003-4984-2631
+Authors Full Name
+ Wang, Ting-Yao; Wang, Rui-Fang; Bu, Zhi-Ying; Targher, Giovanni; Byrne, Christopher D; Sun, Dan-Qin; Zheng, Ming-Hua.
+Institution
+ Wang, Ting-Yao. Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
+ Wang, Rui-Fang. Department of Nephrology, the Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, China.
+ Bu, Zhi-Ying. Department of Nephrology, the Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, China.
+ Targher, Giovanni. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
+ Byrne, Christopher D. Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK.
+ Sun, Dan-Qin. Department of Nephrology, the Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, China. sundanqin@njmu.edu.cn.
+ Sun, Dan-Qin. Affiliated Wuxi Clinical College of Nantong University, Wuxi, China. sundanqin@njmu.edu.cn.
+ Zheng, Ming-Hua. NAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. zhengmh@wmu.edu.cn.
+ Zheng, Ming-Hua. Institute of Hepatology, Wenzhou Medical University, Wenzhou, China. zhengmh@wmu.edu.cn.
+ Zheng, Ming-Hua. Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. zhengmh@wmu.edu.cn.
+MeSH Subject Headings
+ Biomarkers
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2
+ Female
+ Humans
+ Male
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Renal Insufficiency, Chronic/co [Complications]
+ *Renal Insufficiency, Chronic
+Abstract
+ Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in more than 5% of hepatocytes in the absence of excessive alcohol consumption and other secondary causes of hepatic steatosis. In 2020, the more inclusive term metabolic (dysfunction)-associated fatty liver disease (MAFLD) - defined by broader diagnostic criteria - was proposed to replace the term NAFLD. The new terminology and revised definition better emphasize the pathogenic role of metabolic dysfunction and uses a set of definitive, inclusive criteria for diagnosis. Diagnosis of MAFLD is based on evidence of hepatic steatosis (as assessed by liver biopsy, imaging techniques or blood biomarkers and scores) in persons who are overweight or obese and have type 2 diabetes mellitus or metabolic dysregulation, regardless of the coexistence of other liver diseases or excessive alcohol consumption. The known association between NAFLD and chronic kidney disease (CKD) and our understanding that CKD can occur as a consequence of metabolic dysfunction suggests that individuals with MAFLD - who by definition have fatty liver and metabolic comorbidities - are at increased risk of CKD. In this Perspective article, we discuss the clinical associations between MAFLD and CKD, the pathophysiological mechanisms by which MAFLD may increase the risk of CKD and the potential drug treatments that may benefit both conditions. Copyright © 2022. Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41581-021-00519-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1759-5061&title=Nature+Reviews+Nephrology&atitle=Association+of+metabolic+dysfunction-associated+fatty+liver+disease+with+kidney+disease.&volume=18&issue=4&spage=259&epage=268&date=2022&doi=10.1038%2Fs41581-021-00519-y&pmid=35013596&sid=OVID:medline
+
+<596>
+Unique Identifier
+ 35013433
+Title
+ Prevalence, patterns and determinants of dyslipidaemia among South African adults with comorbidities.
+Source
+ Scientific Reports. 12(1):337, 2022 01 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Masilela C; Adeniyi OV; Benjeddou M
+Authors Full Name
+ Masilela, Charity; Adeniyi, Oladele Vincent; Benjeddou, Mongi.
+Institution
+ Masilela, Charity. Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa. chemasilela@gmail.com.
+ Adeniyi, Oladele Vincent. Department of Family Medicine, Walter Sisulu University, East London, 5200, South Africa.
+ Benjeddou, Mongi. Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ *Black People
+ Cross-Sectional Studies
+ Diabetes Mellitus/eh [Ethnology]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/dt [Drug Therapy]
+ *Dyslipidemias/eh [Ethnology]
+ Female
+ Humans
+ Hydroxymethylglutaryl-CoA Reductase Inhibitors/tu [Therapeutic Use]
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Multimorbidity
+ Obesity/eh [Ethnology]
+ Prevalence
+ Race Factors
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ South Africa/ep [Epidemiology]
+ Young Adult
+Abstract
+ The present study assessed the prevalence, patterns and determinants of dyslipidaemia among South African adults with multi-morbidities. In this study, 614 individuals with DM and hypertension were recruited. Dyslipidaemia was defined as elevated levels of total cholesterol (TC) >= 5.2 mmol/L and/or low-density lipoprotein cholesterol (LDL-C) >= 2.6 mmol/L, triglycerides (TG) >= 1.8 mmol/L and low high-density lipoprotein cholesterol (HDL-C) < 1 mmol/L for men and < 1.2 mmol/L for women. Multivariate regression model (adjusted) analysis was used to identify the significant determinants of dyslipidaemia. The prevalence of dyslipidaemia was 76.7% (n = 471), with females showing the highest prevalence 357 (75.79%). Elevated TG (62.21%) was the most prevalent form of dyslipidemia. Only 103 (16.77%) participants were on statin therapy. The multivariate logistic regression model analysis (adjusted) showed that, the Zulu ethnicity (AOR = 2.45; 95%CI 1.48-4.05) was associated with high TC. DM (AOR = 2.00; 95%CI 1.30-3.06) and the female sex (AOR = 2.54; 95%CI 1.56-4.12) were associated with low HDL-C. Obesity (AOR = 1.57; 95%CI 1.12-2.21) and the Zulu ethnicity (AOR = 1.60; 95%CI 1.00-2.54) were associated with elevated LDL-C. DM (AOR = 2.32; 95%CI 1.61-3.34) was associated with elevated TG. We found a high prevalence of dyslipidaemia. The study further demonstrated that prevention and treatment of dyslipidaemia should be prioritised among individuals with multi-morbidities. Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41598-021-04150-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Masilela&issn=2045-2322&title=Scientific+Reports&atitle=Prevalence%2C+patterns+and+determinants+of+dyslipidaemia+among+South+African+adults+with+comorbidities.&volume=12&issue=1&spage=337&epage=&date=2022&doi=10.1038%2Fs41598-021-04150-6&pmid=35013433&sid=OVID:medline
+
+<597>
+Unique Identifier
+ 35012855
+Title
+ Change of cardiovascular risk associated serologic biomarkers after gastric bypass: A comparison of diabetic and non-diabetic Asian patients.
+Source
+ Asian Journal of Surgery. 45(11):2253-2258, 2022 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wei JH; Lee MH; Lee WJ; Chen SC; Almalki OM; Chen JC; Wu CC; Lee YC
+Authors Full Name
+ Wei, Jih-Hua; Lee, Ming-Hsien; Lee, Wei-Jei; Chen, Shu-Chun; Almalki, Owaid M; Chen, Jung-Chien; Wu, Chun-Chi; Lee, Yi-Chih.
+Institution
+ Wei, Jih-Hua. Cardiovascular Division, Internal Medicine Department, Min-Sheng General Hospital, Taoyuan, Taiwan, ROC; Department of Nutrition and Health Sciences, School of Healthcare Management, Kai-Nan University, Taoyuan, Taiwan, ROC; Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan, ROC. Electronic address: jaccwei@yahoo.com.tw.
+ Lee, Ming-Hsien. Metabolic & Bariatric Surgical Department, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan.
+ Lee, Wei-Jei. Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan, ROC. Electronic address: wjlee_obessurg_tw@yahoo.com.tw.
+ Chen, Shu-Chun. Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan, ROC. Electronic address: n002916@e-ms.com.tw.
+ Almalki, Owaid M. Department of Surgery, College of Medicine, Taif University, Saudi Arabia.
+ Chen, Jung-Chien. Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan, ROC.
+ Wu, Chun-Chi. Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan, ROC.
+ Lee, Yi-Chih. Department of International Business, Ching Hsin University, Taoyuan, Taiwan.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/su [Surgery]
+ *Diabetes Mellitus, Type 2
+ Fibroblast Growth Factors
+ Gastric Bypass/mt [Methods]
+ *Gastric Bypass
+ Glycated Hemoglobin/me [Metabolism]
+ Heart Disease Risk Factors
+ Humans
+ Lipoproteins, LDL
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+ Prospective Studies
+ Receptor for Advanced Glycation End Products
+ Risk Factors
+ Treatment Outcome
+Keyword Heading
+ Asian
+ CV risk Score
+ Corin
+ FGF-19
+ FGF-21
+ Gastric bypass
+ T2D
+ UKPDS
+ ox-LDL
+ sRAGE
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: While clinical findings demonstrate a superior benefit of cardiovascular (CV) risk reduction in obese patients with type 2 diabetes mellitus (T2D) receiving bariatric surgery over non-T2D patients, the mechanism is unclear. This study aimed to investigate the changes in the CV risk score and five CV-associated biomarkers after gastric bypass surgery.
+
+ METHOD: We enrolled 80 obese subjects who underwent gastric bypass (40 T2D and 40 non-T2D). CV risks were assessed using the United Kingdom Prospective Diabetes Study (UKPDS) engine before and after surgery. Levels of five biomarkers -fasting serum fibroblast growth factor (FGF)-19, FGF-21, corin, oxidized low-density lipoprotein (ox-LDL), and soluble receptor for advanced glycation end-products (sRAGE)-were measured before surgery and one year after surgery.
+
+ RESULTS: The T2D group was significantly older and had a higher CV risk score than the non-T2D group, but body mass index (BMI) was similar between the groups. Preoperative biomarker levels were similar in both the T2D and the non-T2D groups. One year after surgery, the percentage of total weight loss (%TWL) was similar between the two groups (32.2 +/- 19.5% versus 34.1% +/- 8.8%, p = 0.611). Complete T2D remission (hemoglobin A1c (HbA1c) < 6.0%) was achieved in 29 patients (72.5%). The 10-year CV risk scores by the UKPDS risk engine reduced significantly in both the T2D and the non-T2D groups, but more in the T2D group. Three of five biomarkers changed significantly after surgery: the FGF-19 increased from 195.6 +/- 249.1 pg/mL to 283.2 +/- 211.8 pg/mL, corin increased from 3.3 +/- 2.3 ng/mL to 4.6 +/- 3.7 ng/mL, and ox-LDL decreased from 148.5 +/- 71.7-107.9 U/L; the P values were 0.002, 0.002 and < 0.001, respectively. The T2D group showed a significantly different change in FGF-19 increase and FGF-21 decrease compared to the non-T2D group. The changes in corin and ox-LDL levels were not different between the T2D and non-T2D groups.
+
+ CONCLUSION: Gastric bypass surgery resulted in a higher UKPDS CV risk score reduction in obese T2D Asians than in those without. FGF-19 and FGF-21 may be associated with the underlying mechanism of this difference. Copyright © 2022 Asian Surgical Association and Taiwan Robotic Surgery Association. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Lipoproteins, LDL). 0 (Receptor for Advanced Glycation End Products). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.asjsur.2021.12.064
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wei&issn=1015-9584&title=Asian+Journal+of+Surgery&atitle=Change+of+cardiovascular+risk+associated+serologic+biomarkers+after+gastric+bypass%3A+A+comparison+of+diabetic+and+non-diabetic+Asian+patients.&volume=45&issue=11&spage=2253&epage=2258&date=2022&doi=10.1016%2Fj.asjsur.2021.12.064&pmid=35012855&sid=OVID:medline
+
+<598>
+Unique Identifier
+ 35001410
+Title
+ The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double-blind clinical trial.
+Source
+ British Journal of Clinical Pharmacology. 88(7):3256-3271, 2022 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hooshmand Moghadam B; Rashidlamir A; Attarzadeh Hosseini SR; Gaeini AA; Kaviani M
+Author NameID
+ Hooshmand Moghadam, Babak; ORCID: https://orcid.org/0000-0002-2036-9492
+ Rashidlamir, Amir; ORCID: https://orcid.org/0000-0001-6180-8554
+Authors Full Name
+ Hooshmand Moghadam, Babak; Rashidlamir, Amir; Attarzadeh Hosseini, Seyyed Reza; Gaeini, Abbas Ali; Kaviani, Mojtaba.
+Institution
+ Hooshmand Moghadam, Babak. Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.
+ Rashidlamir, Amir. Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.
+ Attarzadeh Hosseini, Seyyed Reza. Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.
+ Gaeini, Abbas Ali. Department of Exercise Physiology, University of Tehran, Tehran, Iran.
+ Kaviani, Mojtaba. School of Nutrition and Dietetics, Acadia University, Wolfville, Nova Scotia, Canada.
+MeSH Subject Headings
+ Adult
+ Anti-Inflammatory Agents
+ Biomarkers
+ Body Composition
+ C-Reactive Protein
+ *Crocus
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 2
+ Double-Blind Method
+ Humans
+ Interleukin-10
+ Interleukin-6
+ Male
+ Obesity/co [Complications]
+ Obesity/dt [Drug Therapy]
+ Plant Extracts/pd [Pharmacology]
+ Plant Extracts/tu [Therapeutic Use]
+ Tumor Necrosis Factor-alpha
+Keyword Heading
+ Crocus sativus
+ diabetes mellitus
+ inflammation
+ obesity
+ physical exercise training
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Chronic inflammation is one of the major challenges in the management of obesity and type 2 diabetes mellitus (T2DM). Our primary aim was to assess the anti-inflammatory effects of Saffron (Crocus sativus L.) supplementation and concurrent training in obese men with T2DM.
+
+ METHODS: Sixty obese men with T2DM (age = 39 +/- 5 years; body mass = 93.9 +/- 6 kg) were randomly assigned to four groups; concurrent training + placebo (CT; n = 15), saffron supplementation (S; n = 15), concurrent training + saffron supplementation (CTS; n = 15), or control (CON; n = 15). The participants in the CT group performed concurrent training (resistance + aerobic) three times per week for 12 weeks and received daily one pill of placebo (maltodextrin); the participants in the S group supplemented with one pill of 100 mg of saffron daily, and the participants in the CTS group participated in both saffron and training intervention while CON group continued regular lifestyle (no training and no supplementation). Inflammatory markers, body composition (evaluated by a multi-frequency bioelectrical impedance device; Jawon X-Contact 356), and metabolic profile were evaluated before and after interventions.
+
+ RESULTS: All three interventions significantly (P < .05) decreased TNF-alpha (CT = -4.22, S = -1.91, CTS = -9.69 pg/mL), hs-CRP (CT = -0.13, S = -0.1, CTS = -0.32 ng/mL), IL-6 (CT = -6.84, S = -6.36, CTS = -13.55 pg/mL), IL-1beta (CT = -8.85, S = -6.46, CTS = -19.8 pg/mL), FBG (CT = -6.97, S = -2.45, CTS = -13.86 mg/dL), insulin (CT = -0.13, S = -0.03, CTS = -0.21 mU/L), HOMA-IR (CT = -0.12, S = -0.04, CTS = -0.21), HbA1c (CT = -0.17, S = -0.11, CTS = -0.26%), and increased IL-10 (CT = 1.09, S = 0.53, CTS = 2.27 pg/mL) concentrations. There was a positive correlation between changes in BFP with hs-CRP, IL-6, IL-1beta and TNF-alpha, and IL-10 concentrations across the intervention groups. Additionally, significant differences were observed between the changes for all variables in the CTS group compared to CT, S and CON groups (P < .05).
+
+ CONCLUSION: It seems that an interaction of saffron supplementation and concurrent training has more efficient effects on anti-inflammatory status compared to saffron supplementation or concurrent training alone. Copyright © 2022 British Pharmacological Society.
+Registry Number/Name of Substance
+ 0 (Anti-Inflammatory Agents). 0 (Biomarkers). 0 (Interleukin-6). 0 (Plant Extracts). 0 (Tumor Necrosis Factor-alpha). 130068-27-8 (Interleukin-10). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1111%2fbcp.15222
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hooshmand+Moghadam&issn=0306-5251&title=British+Journal+of+Clinical+Pharmacology&atitle=The+effects+of+saffron+%28Crocus+sativus+L.%29+in+conjunction+with+concurrent+training+on+body+composition%2C+glycaemic+status%2C+and+inflammatory+markers+in+obese+men+with+type+2+diabetes+mellitus%3A+A+randomized+double-blind+clinical+trial.&volume=88&issue=7&spage=3256&epage=3271&date=2022&doi=10.1111%2Fbcp.15222&pmid=35001410&sid=OVID:medline
+
+<599>
+Unique Identifier
+ 35000203
+Title
+ Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD.
+Source
+ Hepatology. 76(5):1452-1465, 2022 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moore MP; Cunningham RP; Meers GM; Johnson SA; Wheeler AA; Ganga RR; Spencer NM; Pitt JB; Diaz-Arias A; Swi AIA; Hammoud GM; Ibdah JA; Parks EJ; Rector RS
+Authors Full Name
+ Moore, Mary P; Cunningham, Rory P; Meers, Grace M; Johnson, Sarah A; Wheeler, Andrew A; Ganga, Rama R; Spencer, Nicole M; Pitt, James B; Diaz-Arias, Alberto; Swi, Ahmed I A; Hammoud, Ghassan M; Ibdah, Jamal A; Parks, Elizabeth J; Rector, R Scott.
+Institution
+ Moore, Mary P. Research Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri, USA.
+ Moore, Mary P. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
+ Cunningham, Rory P. Research Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri, USA.
+ Cunningham, Rory P. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
+ Meers, Grace M. Research Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri, USA.
+ Meers, Grace M. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
+ Johnson, Sarah A. Research Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri, USA.
+ Johnson, Sarah A. Department of Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, USA.
+ Wheeler, Andrew A. Department of Surgery, University of Missouri, Columbia, Missouri, USA.
+ Ganga, Rama R. Department of Surgery, University of Missouri, Columbia, Missouri, USA.
+ Spencer, Nicole M. Department of Surgery, University of Missouri, Columbia, Missouri, USA.
+ Pitt, James B. Department of Surgery, University of Missouri, Columbia, Missouri, USA.
+ Diaz-Arias, Alberto. Boyce and Bynum Pathology Professional Services, Columbia, Missouri, USA.
+ Swi, Ahmed I A. Department of Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, USA.
+ Hammoud, Ghassan M. Department of Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, USA.
+ Ibdah, Jamal A. Research Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri, USA.
+ Ibdah, Jamal A. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
+ Ibdah, Jamal A. Department of Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, USA.
+ Parks, Elizabeth J. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
+ Parks, Elizabeth J. Department of Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, USA.
+ Rector, R Scott. Research Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri, USA.
+ Rector, R Scott. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
+ Rector, R Scott. Department of Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, USA.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Humans
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease
+ Reactive Oxygen Species
+ Carbon Dioxide
+ Liver/pa [Pathology]
+ Biomarkers
+ Obesity/pa [Pathology]
+ Inflammation/pa [Pathology]
+ Mitochondrial Turnover
+ Fatty Acids
+ Oxidoreductases
+ Coenzyme A
+Abstract
+ BACKGROUND AND AIMS: NAFLD and its more-advanced form, steatohepatitis (NASH), is associated with obesity and is an independent risk factor for cardiovascular, liver-related, and all-cause mortality. Available human data examining hepatic mitochondrial fatty acid oxidation (FAO) and hepatic mitochondrial turnover in NAFLD and NASH are scant.
+
+ APPROACH AND RESULTS: To investigate this relationship, liver biopsies were obtained from patients with obesity undergoing bariatric surgery and data clustered into four groups based on hepatic histopathological classification: Control (CTRL; no disease); NAFL (steatosis only); Borderline-NASH (steatosis with lobular inflammation or hepatocellular ballooning); and Definite-NASH (D-NASH; steatosis, lobular inflammation, and hepatocellular ballooning). Hepatic mitochondrial complete FAO to CO2 and the rate-limiting enzyme in beta-oxidation (beta-hydroxyacyl-CoA dehydrogenase activity) were reduced by ~40%-50% with D-NASH compared with CTRL. This corresponded with increased hepatic mitochondrial reactive oxygen species production, as well as dramatic reductions in markers of mitochondrial biogenesis, autophagy, mitophagy, fission, and fusion in NAFL and NASH.
+
+ CONCLUSIONS: These findings suggest that compromised hepatic FAO and mitochondrial turnover are intimately linked to increasing NAFLD severity in patients with obesity. Copyright © 2022 American Association for the Study of Liver Diseases.
+Registry Number/Name of Substance
+ 0 (Reactive Oxygen Species). 142M471B3J (Carbon Dioxide). 0 (Biomarkers). 0 (Fatty Acids). EC 1 (Oxidoreductases). SAA04E81UX (Coenzyme A).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2fhep.32324
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moore&issn=0270-9139&title=Hepatology&atitle=Compromised+hepatic+mitochondrial+fatty+acid+oxidation+and+reduced+markers+of+mitochondrial+turnover+in+human+NAFLD.&volume=76&issue=5&spage=1452&epage=1465&date=2022&doi=10.1002%2Fhep.32324&pmid=35000203&sid=OVID:medline
+
+<600>
+Unique Identifier
+ 34996930
+Title
+ The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites.
+Source
+ Scientific Reports. 12(1):294, 2022 01 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yeung KTD; Penney N; Whiley L; Ashrafian H; Lewis MR; Purkayastha S; Darzi A; Holmes E
+Authors Full Name
+ Yeung, Kai Tai Derek; Penney, Nicholas; Whiley, Luke; Ashrafian, Hutan; Lewis, Matthew R; Purkayastha, Sanjay; Darzi, Ara; Holmes, Elaine.
+Institution
+ Yeung, Kai Tai Derek. Department of Surgery & Cancer, Imperial College London, South Kensington, London, UK.
+ Penney, Nicholas. Department of Surgery & Cancer, Imperial College London, South Kensington, London, UK.
+ Whiley, Luke. Department of Surgery & Cancer, Imperial College London, South Kensington, London, UK.
+ Whiley, Luke. Australian National Phenome Centre & Centre for Computational & Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA, Australia.
+ Whiley, Luke. Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London, UK.
+ Ashrafian, Hutan. Department of Surgery & Cancer, Imperial College London, South Kensington, London, UK.
+ Lewis, Matthew R. National Phenome Centre, Imperial College London, South Kensington, London, UK.
+ Lewis, Matthew R. Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London, UK.
+ Purkayastha, Sanjay. Department of Surgery & Cancer, Imperial College London, South Kensington, London, UK.
+ Darzi, Ara. Department of Surgery & Cancer, Imperial College London, South Kensington, London, UK.
+ Holmes, Elaine. Department of Surgery & Cancer, Imperial College London, South Kensington, London, UK. elaine.holmes@imperial.ac.uk.
+ Holmes, Elaine. Australian National Phenome Centre & Centre for Computational & Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA, Australia. elaine.holmes@imperial.ac.uk.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Female
+ *Gastrectomy
+ *Gastric Bypass
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ *Kynurenine/bl [Blood]
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/su [Surgery]
+ Prospective Studies
+ Time Factors
+ Treatment Outcome
+ *Tryptophan/bl [Blood]
+ Xanthurenates/bl [Blood]
+Abstract
+ This study aims to explore the immediate effects of bariatric surgery on serum tryptophan-kynurenine pathway metabolites in individuals with type 2 diabetes and BMI > 30. With the goal of providing insight into the link between tryptophan pathway metabolites, type 2 diabetes, and chronic obesity-induced inflammation. This longitudinal study included 20 participants. Half were diagnosed with type 2 diabetes. 11 and 9 underwent RYGB and SG respectively. Blood samples were obtained at pre-operative and 3 months post-operative timepoints. Tryptophan and downstream metabolites of the kynurenine pathway were quantified with an ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionisation method. At 3 months post-operation, RYGB led to significant reductions in tryptophan, kynurenic acid and xanthurenic acid levels when compared to baseline. Significant reductions of the same metabolites after surgery were also observed in individuals with T2D irrespective of surgical procedure. These metabolites were significantly correlated with serum HbA1c levels and BMI. Bariatric surgery, in particular RYGB reduces serum levels of tryptophan and its downstream kynurenine metabolites. These metabolites are associated with T2D and thought to be potentially mechanistic in the systemic processes of obesity induced inflammation leading to insulin resistance. Its reduction after surgery is associated with an improvement in glycaemic control (HbA1c). Copyright © 2022. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Xanthurenates). 0 (hemoglobin A1c protein, human). 343-65-7 (Kynurenine). 58LAB1BG8J (xanthurenic acid). 8DUH1N11BX (Tryptophan).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41598-021-03833-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yeung&issn=2045-2322&title=Scientific+Reports&atitle=The+impact+of+bariatric+surgery+on+serum+tryptophan-kynurenine+pathway+metabolites.&volume=12&issue=1&spage=294&epage=&date=2022&doi=10.1038%2Fs41598-021-03833-4&pmid=34996930&sid=OVID:medline
+
+<601>
+Unique Identifier
+ 34990470
+Title
+ Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study.
+Source
+ PLoS ONE [Electronic Resource]. 17(1):e0262330, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gar C; Thorand B; Herder C; Sujana C; Heier M; Meisinger C; Peters A; Koenig W; Rathmann W; Roden M; Stumvoll M; Maalmi H; Meitinger T; Then H; Seissler J; Then C
+Author NameID
+ Gar, Christina; ORCID: https://orcid.org/0000-0002-4218-6945
+ Thorand, Barbara; ORCID: https://orcid.org/0000-0002-8416-6440
+ Herder, Christian; ORCID: https://orcid.org/0000-0002-2050-093X
+ Sujana, Chaterina; ORCID: https://orcid.org/0000-0002-0663-2557
+ Koenig, Wolfgang; ORCID: https://orcid.org/0000-0002-2064-9603
+Authors Full Name
+ Gar, Christina; Thorand, Barbara; Herder, Christian; Sujana, Chaterina; Heier, Margit; Meisinger, Christa; Peters, Annette; Koenig, Wolfgang; Rathmann, Wolfgang; Roden, Michael; Stumvoll, Michael; Maalmi, Haifa; Meitinger, Thomas; Then, Holger; Seissler, Jochen; Then, Cornelia.
+Institution
+ Gar, Christina. Department of Medicine IV, University Hospital, LMU Munich, Germany.
+ Gar, Christina. Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, Munich, Germany.
+ Gar, Christina. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Thorand, Barbara. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Thorand, Barbara. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Herder, Christian. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Herder, Christian. Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Herder, Christian. Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Sujana, Chaterina. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Sujana, Chaterina. Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-Universitat, Munich, Germany.
+ Heier, Margit. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Heier, Margit. KORA Study Centre, University Hospital Augsburg, Augsburg, Germany.
+ Meisinger, Christa. Independent Research Group Clinical Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Meisinger, Christa. Chair of Epidemiology at University Hospital Augsburg, Augsburg, Germany.
+ Peters, Annette. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Peters, Annette. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Peters, Annette. DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
+ Koenig, Wolfgang. DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
+ Koenig, Wolfgang. Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
+ Koenig, Wolfgang. Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Munich, Germany.
+ Rathmann, Wolfgang. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Rathmann, Wolfgang. German Diabetes Center, Leibniz Institute at Heinrich Heine University Dusseldorf, Institute of Biometrics and Epidemiology, Dusseldorf, Germany.
+ Roden, Michael. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Roden, Michael. Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Roden, Michael. Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Stumvoll, Michael. Department of Medicine, University of Leipzig, Leipzig, Germany.
+ Maalmi, Haifa. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Maalmi, Haifa. Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Meitinger, Thomas. DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
+ Meitinger, Thomas. Institute of Human Genetics, Technische Universitat Munchen, Munich, Germany.
+ Then, Holger. Freie Waldorfschule Augsburg, Augsburg, Germany.
+ Seissler, Jochen. Department of Medicine IV, University Hospital, LMU Munich, Germany.
+ Seissler, Jochen. Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, Munich, Germany.
+ Seissler, Jochen. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+ Then, Cornelia. Department of Medicine IV, University Hospital, LMU Munich, Germany.
+ Then, Cornelia. Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, Munich, Germany.
+ Then, Cornelia. German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
+MeSH Subject Headings
+ *Adrenomedullin/bl [Blood]
+ Adrenomedullin/me [Metabolism]
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases/mo [Mortality]
+ *Cardiovascular System/me [Metabolism]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/me [Metabolism]
+ *Peptide Fragments/bl [Blood]
+ Prospective Studies
+ *Protein Precursors/bl [Blood]
+ Risk Factors
+Abstract
+ BACKGROUND AND AIM: Despite its vasodilatory effect, adrenomedullin and its surrogate mid-regional pro-adrenomedullin (MR-proADM) have been found to be positively associated with all-cause and cardiovascular mortality. However, the underlying mechanisms thereof remain unclear and the associations were mostly shown in geriatric cohorts or in patients with chronic diseases. Therefore, we aimed to investigate the possible involvement of abdominal obesity, selected adipokines, and biomarkers of subclinical inflammation in the association of MR-proADM with mortality in a population based study cohort.
+
+ METHODS: Prospective analysis of the KORA F4 study; median follow-up 9.1 (8.8-9.4) years. Complete data on MR-proADM and mortality was available for 1551 participants, aged 56.9+/-12.9 years (mean+/-SD). Correlation and regression analyses of MR-proADM with overall (BMI) and abdominal obesity (waist circumference), selected adipokines and biomarkers of subclinical inflammation. Cox proportional hazard models on the association of MR-proADM with all-cause and cardiovascular mortality with adjustment for cardiovascular risk factors and selected biomarkers in study subgroups (n = 603-1551).
+
+ RESULTS: MR-proADM associated with all-cause (HR (95%CI): 2.37 (1.72-3.26) and 2.31 (1.67-3.20)) and cardiovascular mortality (4.28 (2.19-8.39) and 4.44 (2.25-8.76)) after adjustment for traditional cardiovascular risk factors including BMI or waist circumference, respectively. MR-proADM was further associated with four out of seven examined adipokines (leptin, retinol-binding protein-4, chemerin, and adiponectin) and with five out of eleven examined biomarkers of subclinical inflammation (high-sensitivity C-reactive protein, interleukin-6, myeloperoxidase, interleukin-22, and interleukin-1 receptor antagonist) after multivariable adjustment and correction for multiple testing. However, only IL-6 substantially attenuated the association of MR-proADM with all-cause mortality.
+
+ CONCLUSIONS: We found an association of MR-proADM with (abdominal) obesity, selected adipokines, and biomarkers of subclinical inflammation. However, the association of MR-proADM with mortality was independent of these parameters. Future studies should investigate the role of IL-6 and further characteristics of subclinical inflammation in the association between MR-proADM and all-cause mortality.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (Protein Precursors). 0 (mid-regional pro-adrenomedullin, human). 148498-78-6 (Adrenomedullin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1371%2fjournal.pone.0262330
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gar&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Association+of+circulating+MR-proADM+with+all-cause+and+cardiovascular+mortality+in+the+general+population%3A+Results+from+the+KORA+F4+cohort+study.&volume=17&issue=1&spage=e0262330&epage=&date=2022&doi=10.1371%2Fjournal.pone.0262330&pmid=34990470&sid=OVID:medline
+
+<602>
+Unique Identifier
+ 34987204
+Title
+ A behavioral weight-loss intervention, but not metformin, decreases a marker of gut barrier permeability: results from the SPIRIT randomized trial.
+Source
+ International Journal of Obesity. 46(3):655-660, 2022 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tilves C; Yeh HC; Maruthur N; Juraschek SP; Miller ER; Appel LJ; Mueller NT
+Author NameID
+ Tilves, Curtis; ORCID: http://orcid.org/0000-0003-0281-5986
+ Mueller, Noel T; ORCID: http://orcid.org/0000-0002-7412-8352
+Authors Full Name
+ Tilves, Curtis; Yeh, Hsin-Chieh; Maruthur, Nisa; Juraschek, Stephen P; Miller, Edgar R; Appel, Lawrence J; Mueller, Noel T.
+Institution
+ Tilves, Curtis. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
+ Tilves, Curtis. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.
+ Yeh, Hsin-Chieh. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.
+ Maruthur, Nisa. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.
+ Juraschek, Stephen P. Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA.
+ Miller, Edgar R. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.
+ Appel, Lawrence J. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.
+ Mueller, Noel T. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. nmuelle4@jhu.edu.
+ Mueller, Noel T. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. nmuelle4@jhu.edu.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 2
+ Female
+ Humans
+ Lipopolysaccharides
+ Male
+ Metformin/tu [Therapeutic Use]
+ *Metformin
+ Middle Aged
+ Obesity/dt [Drug Therapy]
+ Permeability
+ Weight Loss
+Abstract
+ BACKGROUND/OBJECTIVES: Lipopolysaccharide-binding protein (LBP), a biomarker of gut barrier permeability to lipopolysaccharides, is higher in adults with obesity and type 2 diabetes. Behavioral weight loss and metformin have distinct effects on the gut microbiome, but their impact on gut permeability to lipopolysaccharides is unknown. This study's objective was to determine the effects of a behavioral weight-loss intervention or metformin treatment on plasma LBP.
+
+ SUBJECTS/METHODS: SPIRIT was a randomized trial of adults with overweight or obesity. Participants were randomized to one of three arms: metformin treatment, coach-directed behavioral weight loss on a DASH diet, or self-directed care (control). Of 121 participants, a random subset (n = 88) was selected to have LBP measured at baseline, 6 months, and 12 months post intervention. Intervention effects on LBP over time were assessed using generalized estimating equations (GEE). We also examined whether the intervention effects were modified by change in diet and weight.
+
+ RESULTS: Arms were balanced by sex (83% female), race (51% white), and age (mean 60 years), with no differences in baseline LBP (median 4.23 mug/mL). At 1 year, mean weight change was -3.00% in the metformin arm, -3.02% in the coach-directed behavioral weight-loss arm, and +0.33% in the self-directed (control) arm. The corresponding change in LBP was +1.03, -0.98, +1.03 mug/mL. The behavioral weight-loss intervention reduced LBP compared to self-directed care (beta = -0.17, 95% CI: -0.33 to -0.01); no other between-arm comparisons were significant. Behavioral weight-loss participants who reduced dietary fat showed the greatest reductions in 6-month LBP (beta = -2.84, 95% CI: -5.17 to -0.50).
+
+ CONCLUSIONS: Despite similar weight loss in the behavioral weight loss arm and the metformin arm, only the behavioral weight-loss intervention reduced LBP compared to control. Lifestyle weight-loss interventions that promote a DASH diet may be effective at reducing gut barrier permeability to lipopolysaccharides.
+
+ CLINICAL TRIALS REGISTRATION NUMBER: NCT02431676, https://clinicaltrials.gov. Copyright © 2021. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipopolysaccharides). 9100L32L2N (Metformin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41366-021-01039-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tilves&issn=0307-0565&title=International+Journal+of+Obesity&atitle=A+behavioral+weight-loss+intervention%2C+but+not+metformin%2C+decreases+a+marker+of+gut+barrier+permeability%3A+results+from+the+SPIRIT+randomized+trial.&volume=46&issue=3&spage=655&epage=660&date=2022&doi=10.1038%2Fs41366-021-01039-2&pmid=34987204&sid=OVID:medline
+
+<603>
+Unique Identifier
+ 34987111
+Title
+ Comprehensive Immune Profiling Reveals CD56+ Monocytes and CD31+ Endothelial Cells Are Increased in Severe COVID-19 Disease.
+Source
+ Journal of Immunology. 208(3):685-696, 2022 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dutt TS; LaVergne SM; Webb TL; Baxter BA; Stromberg S; McFann K; Berry K; Tipton M; Alnachoukati O; Zier L; Ebel G; Dunn J; Henao-Tamayo M; Ryan EP
+Author NameID
+ Dutt, Taru S; ORCID: https://orcid.org/0000-0002-5101-1311
+ Webb, Tracy L; ORCID: https://orcid.org/0000-0003-4547-3787
+ McFann, Kim; ORCID: https://orcid.org/0000-0002-9348-9954
+ Dunn, Julie; ORCID: https://orcid.org/0000-0002-9381-9060
+ Ryan, Elizabeth P; ORCID: https://orcid.org/0000-0002-1577-0919
+Authors Full Name
+ Dutt, Taru S; LaVergne, Stephanie M; Webb, Tracy L; Baxter, Bridget A; Stromberg, Sophia; McFann, Kim; Berry, Kailey; Tipton, Madison; Alnachoukati, Omar; Zier, Linda; Ebel, Greg; Dunn, Julie; Henao-Tamayo, Marcela; Ryan, Elizabeth P.
+Institution
+ Dutt, Taru S. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO.
+ LaVergne, Stephanie M. Department of Environmental Radiological and Health Sciences, Colorado State University, Fort Collins, CO.
+ Webb, Tracy L. Department of Clinical Sciences, Colorado State University, Fort Collins, CO.
+ Baxter, Bridget A. Department of Environmental Radiological and Health Sciences, Colorado State University, Fort Collins, CO.
+ Stromberg, Sophia. Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO.
+ McFann, Kim. University of Colorado Health, Medical Center of the Rockies, Loveland, CO.
+ Berry, Kailey. Department of Molecular, Cellular and Integrative Neurosciences, Colorado State University, Fort Collins, CO.
+ Tipton, Madison. Department of Biomedical Sciences, Colorado State University, Fort Collins, CO; and.
+ Alnachoukati, Omar. University of Colorado Health, Medical Center of the Rockies, Loveland, CO.
+ Zier, Linda. University of Colorado Health, Medical Center of the Rockies, Loveland, CO.
+ Ebel, Greg. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO.
+ Dunn, Julie. University of Colorado Health, Medical Center of the Rockies, Loveland, CO.
+ Dunn, Julie. University of Colorado Anschutz School of Medicine, Aurora, CO.
+ Henao-Tamayo, Marcela. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO.
+ Ryan, Elizabeth P. Department of Environmental Radiological and Health Sciences, Colorado State University, Fort Collins, CO; e.p.ryan@colostate.edu.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Age Factors
+ Aged
+ Antibodies, Viral/bi [Biosynthesis]
+ Antibodies, Viral/im [Immunology]
+ Biomarkers
+ CD56 Antigen/an [Analysis]
+ COVID-19/bl [Blood]
+ COVID-19/ep [Epidemiology]
+ *COVID-19/im [Immunology]
+ Child
+ Comorbidity
+ Endothelial Cells/ch [Chemistry]
+ *Endothelial Cells/im [Immunology]
+ Female
+ Flow Cytometry
+ Humans
+ Hypertension/ep [Epidemiology]
+ Hypertension/im [Immunology]
+ Immunophenotyping
+ Lymphocyte Activation
+ Lymphocyte Subsets/im [Immunology]
+ Lymphopenia/et [Etiology]
+ Lymphopenia/im [Immunology]
+ Male
+ Middle Aged
+ Monocytes/ch [Chemistry]
+ *Monocytes/im [Immunology]
+ Neutrophils/im [Immunology]
+ Obesity/ep [Epidemiology]
+ Obesity/im [Immunology]
+ Platelet Endothelial Cell Adhesion Molecule-1/an [Analysis]
+ SARS-CoV-2/im [Immunology]
+ *SARS-CoV-2
+ Severity of Illness Index
+ Spike Glycoprotein, Coronavirus/im [Immunology]
+ Young Adult
+Abstract
+ Immune response dysregulation plays a key role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. In this study, we evaluated immune and endothelial blood cell profiles of patients with coronavirus disease 2019 (COVID-19) to determine critical differences between those with mild, moderate, or severe COVID-19 using spectral flow cytometry. We examined a suite of immune phenotypes, including monocytes, T cells, NK cells, B cells, endothelial cells, and neutrophils, alongside surface and intracellular markers of activation. Our results showed progressive lymphopenia and depletion of T cell subsets (CD3+, CD4+, and CD8+) in patients with severe disease and a significant increase in the CD56+CD14+Ki67+IFN-gamma+ monocyte population in patients with moderate and severe COVID-19 that has not been previously described. Enhanced circulating endothelial cells (CD45-CD31+CD34+CD146+), circulating endothelial progenitors (CD45-CD31+CD34+/-CD146-), and neutrophils (CD11b+CD66b+) were coevaluated for COVID-19 severity. Spearman correlation analysis demonstrated the synergism among age, obesity, and hypertension with upregulated CD56+ monocytes, endothelial cells, and decreased T cells that lead to severe outcomes of SARS-CoV-2 infection. Circulating monocytes and endothelial cells may represent important cellular markers for monitoring postacute sequelae and impacts of SARS-CoV-2 infection during convalescence and for their role in immune host defense in high-risk adults after vaccination. Copyright © 2022 by The American Association of Immunologists, Inc.
+Registry Number/Name of Substance
+ 0 (Antibodies, Viral). 0 (Biomarkers). 0 (CD56 Antigen). 0 (NCAM1 protein, human). 0 (PECAM1 protein, human). 0 (Platelet Endothelial Cell Adhesion Molecule-1). 0 (Spike Glycoprotein, Coronavirus). 0 (spike protein, SARS-CoV-2).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.4049%2fjimmunol.2100830
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dutt&issn=0022-1767&title=Journal+of+Immunology&atitle=Comprehensive+Immune+Profiling+Reveals+CD56%2B+Monocytes+and+CD31%2B+Endothelial+Cells+Are+Increased+in+Severe+COVID-19+Disease.&volume=208&issue=3&spage=685&epage=696&date=2022&doi=10.4049%2Fjimmunol.2100830&pmid=34987111&sid=OVID:medline
+
+<604>
+Unique Identifier
+ 34978374
+Title
+ Effects of colchicine on lipolysis and adipose tissue inflammation in adults with obesity and metabolic syndrome.
+Source
+ Obesity. 30(2):358-368, 2022 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Levine JA; Sarrafan-Chaharsoughi Z; Patel TP; Brady SM; Chivukula KK; Miller E; Han JM; Periwal V; Wolska A; Remaley AT; Dagur PK; Biancotto A; Babyak A; Fantoni G; Yanovski JA; Demidowich AP
+Author NameID
+ Sarrafan-Chaharsoughi, Zahra; ORCID: https://orcid.org/0000-0002-7674-2305
+ Brady, Sheila M; ORCID: https://orcid.org/0000-0002-2333-3575
+ Periwal, Vipul; ORCID: https://orcid.org/0000-0002-8811-8884
+ Remaley, Alan T; ORCID: https://orcid.org/0000-0001-5839-7280
+ Dagur, Pradeep K; ORCID: https://orcid.org/0000-0002-4491-0853
+ Biancotto, Angelique; ORCID: https://orcid.org/0000-0003-2271-009X
+ Babyak, Ashley; ORCID: https://orcid.org/0000-0002-2399-5122
+ Fantoni, Giovanna; ORCID: https://orcid.org/0000-0002-1920-587X
+ Yanovski, Jack A; ORCID: https://orcid.org/0000-0001-8542-1637
+ Demidowich, Andrew P; ORCID: https://orcid.org/0000-0002-5925-1117
+Authors Full Name
+ Levine, Jordan A; Sarrafan-Chaharsoughi, Zahra; Patel, Tushar P; Brady, Sheila M; Chivukula, K Karthik; Miller, Emily; Han, Jung Min; Periwal, Vipul; Wolska, Anna; Remaley, Alan T; Dagur, Pradeep K; Biancotto, Angelique; Babyak, Ashley; Fantoni, Giovanna; Yanovski, Jack A; Demidowich, Andrew P.
+Institution
+ Levine, Jordan A. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
+ Sarrafan-Chaharsoughi, Zahra. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
+ Patel, Tushar P. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
+ Brady, Sheila M. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
+ Chivukula, K Karthik. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
+ Chivukula, K Karthik. Clinical Endocrinology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
+ Miller, Emily. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
+ Han, Jung Min. Computational Medicine Section, Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
+ Periwal, Vipul. Computational Medicine Section, Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
+ Wolska, Anna. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
+ Remaley, Alan T. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
+ Dagur, Pradeep K. Flow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
+ Biancotto, Angelique. Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
+ Babyak, Ashley. Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
+ Fantoni, Giovanna. Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
+ Yanovski, Jack A. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
+ Demidowich, Andrew P. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
+ Demidowich, Andrew P. Johns Hopkins Community Physicians at Howard County General Hospital, Johns Hopkins Medicine, Columbia, Maryland, USA.
+ Demidowich, Andrew P. Department of Endocrinology, Diabetes and Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adult
+ Biomarkers/me [Metabolism]
+ Colchicine/me [Metabolism]
+ Colchicine/pd [Pharmacology]
+ Colchicine/tu [Therapeutic Use]
+ Humans
+ Inflammation/me [Metabolism]
+ Insulin/me [Metabolism]
+ *Insulin Resistance
+ Lipolysis
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome
+ Obesity/co [Complications]
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+Abstract
+ OBJECTIVE: The aim of this study was to examine whether colchicine's anti-inflammatory effects would improve measures of lipolysis and distribution of leukocyte populations in subcutaneous adipose tissue (SAT).
+
+ METHODS: A secondary analysis was conducted for a double-blind, randomized, placebo-controlled pilot study in which 40 adults with obesity and metabolic syndrome (MetS) were randomized to colchicine 0.6 mg or placebo twice daily for 3 months. Non-insulin-suppressible (l0 ), insulin-suppressible (l2 ), and maximal (l0 +l2 ) lipolysis rates were calculated by minimal model analysis. Body composition was determined by dual-energy x-ray absorptiometry. SAT leukocyte populations were characterized by flow cytometry analysis from biopsied samples obtained before and after the intervention.
+
+ RESULTS: Colchicine treatment significantly decreased l2 and l0 +l2 versus placebo (p < 0.05). These changes were associated with a significant reduction in markers of systemic inflammation, including high-sensitivity C-reactive protein, resistin, and circulating monocytes and neutrophils (p < 0.01). Colchicine did not significantly alter SAT leukocyte population distributions (p > 0.05).
+
+ CONCLUSIONS: In adults with obesity and MetS, colchicine appears to improve insulin regulation of lipolysis and reduce markers of systemic inflammation independent of an effect on local leukocyte distributions in SAT. Further studies are needed to better understand the mechanisms by which colchicine affects adipose tissue metabolic pathways in adults with obesity and MetS. Copyright Published 2021. This article is a U.S.Government work and is in the public domain in the USA.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). SML2Y3J35T (Colchicine).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2foby.23341
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Levine&issn=1930-7381&title=Obesity&atitle=Effects+of+colchicine+on+lipolysis+and+adipose+tissue+inflammation+in+adults+with+obesity+and+metabolic+syndrome.&volume=30&issue=2&spage=358&epage=368&date=2022&doi=10.1002%2Foby.23341&pmid=34978374&sid=OVID:medline
+
+<605>
+Unique Identifier
+ 34971370
+Title
+ Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 107(5):e2008-e2020, 2022 04 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Qadri S; Ahlholm N; Lonsmann I; Pellegrini P; Poikola A; Luukkonen PK; Porthan K; Juuti A; Sammalkorpi H; Penttila AK; D'Ambrosio R; Soardo G; Leeming DJ; Karsdal M; Arola J; Kechagias S; Pelusi S; Ekstedt M; Valenti L; Hagstrom H; Yki-Jarvinen H
+Author NameID
+ Qadri, Sami; ORCID: https://orcid.org/0000-0001-9313-9324
+ Luukkonen, Panu K; ORCID: https://orcid.org/0000-0003-2085-679X
+ Penttila, Anne K; ORCID: https://orcid.org/0000-0001-7480-8959
+ Soardo, Giorgio; ORCID: https://orcid.org/0000-0003-3181-5651
+ Leeming, Diana J; ORCID: https://orcid.org/0000-0002-4256-140X
+ Karsdal, Morten; ORCID: https://orcid.org/0000-0001-5026-8740
+ Arola, Johanna; ORCID: https://orcid.org/0000-0003-3865-5507
+ Kechagias, Stergios; ORCID: https://orcid.org/0000-0001-7614-739X
+ Ekstedt, Mattias; ORCID: https://orcid.org/0000-0002-5590-8601
+ Valenti, Luca; ORCID: https://orcid.org/0000-0001-8909-0345
+ Hagstrom, Hannes; ORCID: https://orcid.org/0000-0002-8474-1759
+ Yki-Jarvinen, Hannele; ORCID: https://orcid.org/0000-0001-6766-1549
+Authors Full Name
+ Qadri, Sami; Ahlholm, Noora; Lonsmann, Ida; Pellegrini, Paola; Poikola, Anni; Luukkonen, Panu K; Porthan, Kimmo; Juuti, Anne; Sammalkorpi, Henna; Penttila, Anne K; D'Ambrosio, Roberta; Soardo, Giorgio; Leeming, Diana J; Karsdal, Morten; Arola, Johanna; Kechagias, Stergios; Pelusi, Serena; Ekstedt, Mattias; Valenti, Luca; Hagstrom, Hannes; Yki-Jarvinen, Hannele.
+Institution
+ Qadri, Sami. Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Qadri, Sami. Minerva Foundation Institute for Medical Research, Helsinki, Finland.
+ Ahlholm, Noora. Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Ahlholm, Noora. Minerva Foundation Institute for Medical Research, Helsinki, Finland.
+ Lonsmann, Ida. Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.
+ Pellegrini, Paola. VLVbio AB, Nacka, Sweden.
+ Poikola, Anni. Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Poikola, Anni. Minerva Foundation Institute for Medical Research, Helsinki, Finland.
+ Luukkonen, Panu K. Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Luukkonen, Panu K. Minerva Foundation Institute for Medical Research, Helsinki, Finland.
+ Luukkonen, Panu K. Yale School of Medicine, Yale University, New Haven, CT,USA.
+ Porthan, Kimmo. Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Porthan, Kimmo. Minerva Foundation Institute for Medical Research, Helsinki, Finland.
+ Juuti, Anne. Department of Gastrointestinal Surgery, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Sammalkorpi, Henna. Department of Gastrointestinal Surgery, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Penttila, Anne K. Department of Gastrointestinal Surgery, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ D'Ambrosio, Roberta. Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
+ Soardo, Giorgio. Clinic of Internal Medicine-Liver Unit, Department of Medical Area (DAME), Universita degli Studi di Udine, Udine, Italy.
+ Soardo, Giorgio. Italian Liver Foundation, Area Science Park, Basovizza Campus, Trieste, Italy.
+ Leeming, Diana J. Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.
+ Karsdal, Morten. Nordic Bioscience, Biomarkers and Research, Herlev, Denmark.
+ Arola, Johanna. Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Kechagias, Stergios. Department of Health, Medicine, and Caring Sciences, Linkoping University, Linkoping, Sweden.
+ Pelusi, Serena. Precision Medicine-Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
+ Pelusi, Serena. Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milan, Italy.
+ Ekstedt, Mattias. Department of Health, Medicine, and Caring Sciences, Linkoping University, Linkoping, Sweden.
+ Valenti, Luca. Precision Medicine-Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
+ Valenti, Luca. Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milan, Italy.
+ Hagstrom, Hannes. Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
+ Yki-Jarvinen, Hannele. Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Yki-Jarvinen, Hannele. Minerva Foundation Institute for Medical Research, Helsinki, Finland.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Aspartate Aminotransferases
+ Biomarkers
+ Biopsy
+ Cross-Sectional Studies
+ Fibrosis
+ Humans
+ Liver/pa [Pathology]
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/et [Etiology]
+ Liver Cirrhosis/pa [Pathology]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+Keyword Heading
+ biomarkers
+ cirrhosis
+ fibrosis
+ nonalcoholic fatty liver disease
+ nonalcoholic steatohepatitis
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Guidelines recommend blood-based fibrosis biomarkers to identify advanced nonalcoholic fatty liver disease (NAFLD), which is particularly prevalent in patients with obesity.
+
+ OBJECTIVE: To study whether the degree of obesity affects the performance of liver fibrosis biomarkers in NAFLD.
+
+ DESIGN: Cross-sectional cohort study comparing simple fibrosis scores [Fibrosis-4 Index (FIB-4); NAFLD Fibrosis Score (NFS); aspartate aminotransferase to platelet ratio index; BARD (body mass index, aspartate-to-alanine aminotransferase ratio, diabetes); Hepamet Fibrosis Score (HFS)] and newer scores incorporating neo-epitope biomarkers PRO-C3 (ADAPT, FIBC3) or cytokeratin 18 (MACK-3).
+
+ SETTING: Tertiary referral center.
+
+ PATIENTS: We recruited overweight/obese patients from endocrinology (n = 307) and hepatology (n = 71) clinics undergoing a liver biopsy [median body mass index (BMI) 40.3 (interquartile range 36.0-44.7) kg/m2]. Additionally, we studied 859 less obese patients with biopsy-proven NAFLD to derive BMI-adjusted cutoffs for NFS.
+
+ MAIN OUTCOME MEASURES: Biomarker area under the receiver operating characteristic (AUROC), sensitivity, specificity, and predictive values to identify histological stage >=F3 fibrosis or nonalcoholic steatohepatitis with >=F2 fibrosis [fibrotic nonalcoholic steatohepatitis (NASH)].
+
+ RESULTS: The scores with an AUROC >=0.85 to identify >=F3 fibrosis were ADAPT, FIB-4, FIBC3, and HFS. For fibrotic NASH, the best predictors were MACK-3 and ADAPT. The specificities of NFS, BARD, and FIBC3 deteriorated as a function of BMI. We derived and validated new cutoffs for NFS to rule in/out >=F3 fibrosis in groups with BMIs <30.0, 30.0 to 39.9, and >=40.0 kg/m2. This optimized its performance at all levels of BMI. Sequentially combining FIB-4 with ADAPT or FIBC3 increased specificity to diagnose >=F3 fibrosis.
+
+ CONCLUSIONS: In obese patients, the best-performing fibrosis biomarkers are ADAPT and the inexpensive FIB-4, which are unaffected by BMI. The widely used NFS loses specificity in obese individuals, which may be corrected with BMI-adjusted cutoffs. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-1 (Aspartate Aminotransferases).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1210%2fclinem%2fdgab933
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Qadri&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Obesity+Modifies+the+Performance+of+Fibrosis+Biomarkers+in+Nonalcoholic+Fatty+Liver+Disease.&volume=107&issue=5&spage=e2008&epage=e2020&date=2022&doi=10.1210%2Fclinem%2Fdgab933&pmid=34971370&sid=OVID:medline
+
+<606>
+Unique Identifier
+ 34940790
+Title
+ Targeting PLD2 in adipocytes augments adaptive thermogenesis by improving mitochondrial quality and quantity in mice.
+Source
+ Journal of Experimental Medicine. 219(2), 2022 02 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim HS; Park MY; Yun NJ; Go HS; Kim MY; Seong JK; Lee M; Kang ES; Ghim J; Ryu SH; Zabel BA; Koh A; Bae YS
+Author NameID
+ Kim, Hyung Sik; ORCID: https://orcid.org/0000-0001-8167-5058
+ Park, Min Young; ORCID: https://orcid.org/0000-0001-9908-0941
+ Yun, Nam Joo; ORCID: https://orcid.org/0000-0001-9331-7805
+ Go, Hye Sun; ORCID: https://orcid.org/0000-0003-4602-6751
+ Kim, Mi Young; ORCID: https://orcid.org/0000-0001-6668-0668
+ Seong, Je Kyung; ORCID: https://orcid.org/0000-0003-1177-6958
+ Lee, Minyoung; ORCID: https://orcid.org/0000-0002-9333-7512
+ Kang, Eun Seok; ORCID: https://orcid.org/0000-0002-0364-4675
+ Ghim, Jaewang; ORCID: https://orcid.org/0000-0003-3568-6746
+ Ryu, Sung Ho; ORCID: https://orcid.org/0000-0003-0913-3048
+ Zabel, Brian A; ORCID: https://orcid.org/0000-0001-7293-6180
+ Koh, Ara; ORCID: https://orcid.org/0000-0001-7673-034X
+ Bae, Yoe-Sik; ORCID: https://orcid.org/0000-0002-6198-4512
+Authors Full Name
+ Kim, Hyung Sik; Park, Min Young; Yun, Nam Joo; Go, Hye Sun; Kim, Mi Young; Seong, Je Kyung; Lee, Minyoung; Kang, Eun Seok; Ghim, Jaewang; Ryu, Sung Ho; Zabel, Brian A; Koh, Ara; Bae, Yoe-Sik.
+Institution
+ Kim, Hyung Sik. Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
+ Park, Min Young. Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
+ Yun, Nam Joo. Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
+ Go, Hye Sun. Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
+ Go, Hye Sun. Korea Mouse Phenotyping Center, Seoul National University, Seoul, Republic of Korea.
+ Kim, Mi Young. Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
+ Kim, Mi Young. Korea Mouse Phenotyping Center, Seoul National University, Seoul, Republic of Korea.
+ Seong, Je Kyung. Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
+ Seong, Je Kyung. Korea Mouse Phenotyping Center, Seoul National University, Seoul, Republic of Korea.
+ Lee, Minyoung. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
+ Kang, Eun Seok. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
+ Ghim, Jaewang. Department of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea.
+ Ryu, Sung Ho. Department of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea.
+ Zabel, Brian A. Palo Alto Veterans Institute for Research, Veterans Affairs Hospital, Palo Alto, CA.
+ Koh, Ara. Department of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea.
+ Bae, Yoe-Sik. Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
+MeSH Subject Headings
+ *Adipocytes/me [Metabolism]
+ Animals
+ Biomarkers
+ Blood Glucose
+ Diet, High-Fat
+ Energy Metabolism
+ Enzyme Inhibitors/pd [Pharmacology]
+ Gene Expression Regulation
+ Immunohistochemistry
+ Insulin Resistance
+ Male
+ Mice
+ Mice, Knockout
+ *Mitochondria/ge [Genetics]
+ *Mitochondria/me [Metabolism]
+ Mitochondria/ul [Ultrastructure]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Phospholipase D/ai [Antagonists & Inhibitors]
+ *Phospholipase D/ge [Genetics]
+ Phospholipase D/me [Metabolism]
+ Proteasome Endopeptidase Complex/me [Metabolism]
+ *Thermogenesis/ge [Genetics]
+ Uncoupling Protein 1/ge [Genetics]
+ Uncoupling Protein 1/me [Metabolism]
+Abstract
+ Phospholipase D (PLD)2 via its enzymatic activity regulates cell proliferation and migration and thus is implicated in cancer. However, the role of PLD2 in obesity and type 2 diabetes has not previously been investigated. Here, we show that during diet-induced thermogenesis and obesity, levels of PLD2 but not PLD1 in adipose tissue are inversely related with uncoupling protein 1, a key thermogenic protein. We demonstrate that the thermogenic program in adipose tissue is significantly augmented in mice with adipocyte-specific Pld2 deletion or treated with a PLD2-specific inhibitor and that these mice are resistant to high fat diet-induced obesity, glucose intolerance, and insulin resistance. Mechanistically, we show that Pld2 deletion in adipose tissue or PLD2 pharmacoinhibition acts via p62 to improve mitochondrial quality and quantity in adipocytes. Thus, PLD2 inhibition is an attractive therapeutic approach for obesity and type 2 diabetes by resolving defects in diet-induced thermogenesis. Copyright © 2021 Kim et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Enzyme Inhibitors). 0 (Uncoupling Protein 1). EC 3-1-4 (phospholipase D2). EC 3-1-4-4 (Phospholipase D). EC 3-4-25-1 (Proteasome Endopeptidase Complex).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1084%2fjem.20211523
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=0022-1007&title=Journal+of+Experimental+Medicine&atitle=Targeting+PLD2+in+adipocytes+augments+adaptive+thermogenesis+by+improving+mitochondrial+quality+and+quantity+in+mice.&volume=219&issue=2&spage=&epage=&date=2022&doi=10.1084%2Fjem.20211523&pmid=34940790&sid=OVID:medline
+
+<607>
+Unique Identifier
+ 34936501
+Title
+ Stress system dysfunction revealed by integrating reactivity of stress pathways to psychological stress in lean and overweight/obese men.
+Source
+ American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 322(2):R144-R151, 2022 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jayasinghe SU; Hall SJ; Torres SJ; Turner AI
+Author NameID
+ Jayasinghe, Sisitha Udara; ORCID: https://orcid.org/0000-0001-8805-385X
+ Turner, Anne Isabella; ORCID: https://orcid.org/0000-0002-0682-2860
+Authors Full Name
+ Jayasinghe, Sisitha Udara; Hall, Sarah Janet; Torres, Susan Jane; Turner, Anne Isabella.
+Institution
+ Jayasinghe, Sisitha Udara. Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
+ Jayasinghe, Sisitha Udara. College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia.
+ Hall, Sarah Janet. Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
+ Torres, Susan Jane. Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
+ Turner, Anne Isabella. Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
+MeSH Subject Headings
+ Adiposity
+ *Adrenal Medulla/ir [Innervation]
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Pressure
+ Heart Rate
+ Humans
+ Hydrocortisone/me [Metabolism]
+ Hypothalamo-Hypophyseal System/me [Metabolism]
+ *Hypothalamo-Hypophyseal System/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Obesity/px [Psychology]
+ Saliva/en [Enzymology]
+ Stress, Psychological/me [Metabolism]
+ *Stress, Psychological/pp [Physiopathology]
+ Stress, Psychological/px [Psychology]
+ *Sympathetic Nervous System/pp [Physiopathology]
+ Thinness/me [Metabolism]
+ *Thinness/pp [Physiopathology]
+ Thinness/px [Psychology]
+ alpha-Amylases/me [Metabolism]
+Keyword Heading
+ blood pressure
+ cortisol
+ hypothalamo-pituitary adrenal axis
+ salivary alpha amylase
+ sympathoadrenal medullary system
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Although the patterns of response within the sympathoadrenal medullary (SAM) system and hypothalamo-pituitary adrenal (HPA) axis are interesting and important in their own accord, the overall response to acute psychological stress involves reactivity of both pathways. We tested the hypothesis that consideration of the integrated response of these pathways may reveal dysregulation of the stress systems, which is not evident when considering either system alone. Age-matched lean and overweight/obese men were subjected to a Trier Social Stress Test and reactivity of the SAM system (salivary alpha-amylase, systolic blood pressure, diastolic blood pressure, and heart rate) and the HPA axis (salivary cortisol) were measured. Relative reactivity of SAM system and HPA axis was calculated as the ratio between the measures from each pathway. Although analysis of reactivity of individual stress pathways showed no evidence of dysfunction in overweight/obese compared with lean men, analysis of HPA/SAM reactivity revealed significantly lower cortisol over systolic blood pressure (CoSBP) and cortisol over diastolic blood pressure (CoDBP) reactivity in overweight/obese compared with lean men. Other measures of HPA/SAM reactivity and all measures of SAM/HPA reactivity were unaltered in overweight/obese compared with lean men. These findings suggest that the cortisol response per unit of blood pressure response is blunted in men with elevated adiposity. Furthermore, these findings support a notion of a coordinated overall approach to activation of the stress pathways with the degree of activation in one pathway being related to the degree of activation in the other.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-2-1-1 (alpha-Amylases). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1152%2fajpregu.00276.2021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jayasinghe&issn=0363-6119&title=American+Journal+of+Physiology+-+Regulatory+Integrative+%26+Comparative+Physiology&atitle=Stress+system+dysfunction+revealed+by+integrating+reactivity+of+stress+pathways+to+psychological+stress+in+lean+and+overweight%2Fobese+men.&volume=322&issue=2&spage=R144&epage=R151&date=2022&doi=10.1152%2Fajpregu.00276.2021&pmid=34936501&sid=OVID:medline
+
+<608>
+Unique Identifier
+ 34933097
+Title
+ The Effect of Spironolactone in Patients With Obesity at Risk for Heart Failure: Proteomic Insights from the HOMAGE Trial.
+Source
+ Journal of Cardiac Failure. 28(5):778-786, 2022 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Verdonschot JAJ; Ferreira JP; Pizard A; Pellicori P; Brunner La Rocca HP; Clark AL; Cosmi F; Cuthbert J; Girerd N; Waring OJ; Henkens MHTM; Mariottoni B; Petutschnigg J; Rossignol P; Hazebroek MR; Cleland JGF; Zannad F; Heymans SRB
+Corporate Author
+ HOMAGE "Heart Omics in AGEing" Consortium
+Authors Full Name
+ Verdonschot, Job A J; Ferreira, JoAo Pedro; Pizard, Anne; Pellicori, Pierpaolo; Brunner La Rocca, Hans-Peter; Clark, Andrew L; Cosmi, Franco; Cuthbert, Joe; Girerd, Nicolas; Waring, Olivia J; Henkens, Michiel H T M; Mariottoni, Beatrice; Petutschnigg, Johannes; Rossignol, Patrick; Hazebroek, Mark R; Cleland, John G F; Zannad, Faiez; Heymans, Stephane R B.
+Institution
+ Verdonschot, Job A J. Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.
+ Ferreira, JoAo Pedro. Universite de Lorraine, Inserm, Centre d'Investigation Clinique Plurithe'matique 1433, CHRU de Nancy, F-CRIN INI-CRCT, Nancy, France.
+ Pizard, Anne. Universite de Lorraine, Inserm, Centre d'Investigation Clinique Plurithe'matique 1433, CHRU de Nancy, F-CRIN INI-CRCT, Nancy, France.
+ Pellicori, Pierpaolo. Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
+ Brunner La Rocca, Hans-Peter. Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands.
+ Clark, Andrew L. Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, East Riding of Yorkshire, UK.
+ Cosmi, Franco. Department of Cardiology, Cortona Hospital, Arezzo, Italy.
+ Cuthbert, Joe. Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, East Riding of Yorkshire, UK.
+ Girerd, Nicolas. Universite de Lorraine, Inserm, Centre d'Investigation Clinique Plurithe'matique 1433, CHRU de Nancy, F-CRIN INI-CRCT, Nancy, France.
+ Waring, Olivia J. Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands.
+ Henkens, Michiel H T M. Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands.
+ Mariottoni, Beatrice. Department of Cardiology, Cortona Hospital, Arezzo, Italy.
+ Petutschnigg, Johannes. Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charite University Medicine Berlin, Berlin Institute of Health (BIH), and German Centre for Cardiovascular research (DZHK), Berlin, Germany.
+ Rossignol, Patrick. Universite de Lorraine, Inserm, Centre d'Investigation Clinique Plurithe'matique 1433, CHRU de Nancy, F-CRIN INI-CRCT, Nancy, France.
+ Hazebroek, Mark R. Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands.
+ Cleland, John G F. Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
+ Zannad, Faiez. Universite de Lorraine, Inserm, Centre d'Investigation Clinique Plurithe'matique 1433, CHRU de Nancy, F-CRIN INI-CRCT, Nancy, France.
+ Heymans, Stephane R B. Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: s.heymans@maastrichtuniversity.nl.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Biomarkers
+ Female
+ *Glucose Intolerance
+ *Heart Failure
+ Humans
+ Male
+ Mineralocorticoid Receptor Antagonists
+ Obesity/co [Complications]
+ Obesity/dt [Drug Therapy]
+ Proteomics
+ Spironolactone/tu [Therapeutic Use]
+ Treatment Outcome
+Keyword Heading
+ Obesity
+ biomarker
+ heart failure
+ spironolactone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Adipose tissue influences the expression and degradation of circulating biomarkers. We aimed to identify the biomarker profile and biological meaning of biomarkers associated with obesity to assess the effect of spironolactone on the circulating biomarkers and to explore whether obesity might modify the effect of spironolactone.
+
+ METHODS AND RESULTS: Protein biomarkers (n=276) from the Olink Proseek-Multiplex cardiovascular and inflammation panels were measured in plasma collected at baseline, 1 month and 9 months from the HOMAGE randomized controlled trial participants. Of the 510 participants, 299 had obesity defined as an increased waist circumference (>=102 cm in men and >=88 cm in women). Biomarkers at baseline reflected adipogenesis, increased vascularization, decreased fibrinolysis, and glucose intolerance in patients with obesity at baseline. Treatment with spironolactone had only minor effects on this proteomic profile. Obesity modified the effect of spironolactone on systolic blood pressure (Pinteraction=0.001), showing a stronger decrease of blood pressure in obese patients (-14.8 mm Hg 95% confidence interval -18.45 to -11.12) compared with nonobese patients (-3.6 mm Hg 95% confidence interval -7.82 to 0.66).
+
+ CONCLUSIONS: Among patients at risk for heart failure, those with obesity have a characteristic proteomic profile reflecting adipogenesis and glucose intolerance. Spironolactone had only minor effects on this obesity-related proteomic profile, but obesity significantly modified the effect of spironolactone on systolic blood pressure. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Mineralocorticoid Receptor Antagonists). 27O7W4T232 (Spironolactone).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.cardfail.2021.12.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Verdonschot&issn=1071-9164&title=Journal+of+Cardiac+Failure&atitle=The+Effect+of+Spironolactone+in+Patients+With+Obesity+at+Risk+for+Heart+Failure%3A+Proteomic+Insights+from+the+HOMAGE+Trial.&volume=28&issue=5&spage=778&epage=786&date=2022&doi=10.1016%2Fj.cardfail.2021.12.005&pmid=34933097&sid=OVID:medline
+
+<609>
+Unique Identifier
+ 34904367
+Title
+ Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.
+Source
+ Journal of Clinical Hypertension. 24(1):47-57, 2022 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sun J; Sun M; Su Y; Li M; Ma S; Zhang Y; Zhang A; Cai S; Cheng B; Bao Q; Zhu P; Wang S
+Author NameID
+ Wang, Shuxia; ORCID: https://orcid.org/0000-0001-9750-8668
+Authors Full Name
+ Sun, Jin; Sun, Mingyan; Su, Yongkang; Li, Man; Ma, Shouyuan; Zhang, Yan; Zhang, Anhang; Cai, Shuang; Cheng, Bokai; Bao, Qiligeer; Zhu, Ping; Wang, Shuxia.
+Institution
+ Sun, Jin. Medical School of Chinese PLA, Beijing, China.
+ Sun, Jin. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Sun, Mingyan. Department of Ninth Health, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Su, Yongkang. Medical School of Chinese PLA, Beijing, China.
+ Su, Yongkang. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Li, Man. Medical School of Chinese PLA, Beijing, China.
+ Li, Man. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Ma, Shouyuan. Department of Geriatric Cardiology, the second Medical Center, Chinese PLA General Hospital, Beijing, China.
+ Zhang, Yan. Department of Outpatient, the first Medical Center, Chinese PLA General Hospital, Beijing, China.
+ Zhang, Anhang. Medical School of Chinese PLA, Beijing, China.
+ Zhang, Anhang. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Cai, Shuang. Medical School of Chinese PLA, Beijing, China.
+ Cai, Shuang. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Cheng, Bokai. Medical School of Chinese PLA, Beijing, China.
+ Cheng, Bokai. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Bao, Qiligeer. Medical School of Chinese PLA, Beijing, China.
+ Bao, Qiligeer. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Zhu, Ping. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+ Wang, Shuxia. Department of Geriatrics, the second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers
+ Blood Glucose/an [Analysis]
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Glucose
+ Humans
+ Hypertension/co [Complications]
+ Hypertension/ep [Epidemiology]
+ *Hypertension
+ Hyperuricemia/co [Complications]
+ Hyperuricemia/ep [Epidemiology]
+ *Hyperuricemia
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Risk Factors
+ Triglycerides
+ Uric Acid
+Keyword Heading
+ hypertension
+ hyperuricemia
+ mediation effect
+ obesity
+ triglyceride-glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship between the TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated. A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) x fasting plasma glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid >=357mumol/L (6 mg/dl) for females and >=417mumol/L (7 mg/dl) for males. Our study suggested that the TyG index was higher in patients with hyperuricemia than in those without (8.99+/-0.61, 8.70+/-0.59, p < .001). The prevalence of hyperuricemia in patients with the lowest (<=8.32), second (8.33-8.66), third (8.67-9.07) and the highest quartile (>=9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased hyperuricemia risk whether in crude or adjusted models (p < .05). Mediation analysis showed that all of our obesity indexes partially mediated the association between the TyG index and hyperuricemia to some extent. In Conclusions, the TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship. Copyright © 2021 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides). 268B43MJ25 (Uric Acid). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1111%2fjch.14405
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sun&issn=1524-6175&title=Journal+of+Clinical+Hypertension&atitle=Mediation+effect+of+obesity+on+the+association+between+triglyceride-glucose+index+and+hyperuricemia+in+Chinese+hypertension+adults.&volume=24&issue=1&spage=47&epage=57&date=2022&doi=10.1111%2Fjch.14405&pmid=34904367&sid=OVID:medline
+
+<610>
+Unique Identifier
+ 34897581
+Title
+ Circulating levels of adropin and overweight/obesity: a systematic review and meta-analysis of observational studies. [Review]
+Source
+ Hormones. 21(1):15-22, 2022 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Soltani S; Kolahdouz-Mohammadi R; Aydin S; Yosaee S; Clark CCT; Abdollahi S
+Author NameID
+ Abdollahi, Shima; ORCID: http://orcid.org/0000-0002-2638-7448
+Authors Full Name
+ Soltani, Sepideh; Kolahdouz-Mohammadi, Roya; Aydin, Suleyman; Yosaee, Somaye; Clark, Cain C T; Abdollahi, Shima.
+Institution
+ Soltani, Sepideh. Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Kolahdouz-Mohammadi, Roya. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Aydin, Suleyman. Department of Medical Biochemistry, Firat Hormone Research Group), School of Medicine, Firat University, Elazig, Turkey.
+ Yosaee, Somaye. Department of Nutrition Sciences, School of Health, Larestan University of Medical Sciences, Larestan, Iran.
+ Clark, Cain C T. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, UK.
+ Abdollahi, Shima. Department of Nutrition and Public Health, School of Public Health, North Khorasan University of Medical Sciences, 74877-94149, Bojnurd, Iran. sh.abd6864@yahoo.com.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Humans
+ *Metabolic Diseases
+ Obesity
+ Observational Studies as Topic
+ *Overweight
+Keyword Heading
+ Adropin
+ Meta-analysis
+ Obesity
+ Observational studies
+ Overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The association between circulating adropin levels and overweight/obesity is currently unclear. The aim of this study was thus to investigate and seek to determine the association between circulating adropin levels and overweight/obesity using the meta-analysis approach of observational studies. A comprehensive literature search was carried out through the PubMed, Web of Science, and SCOPUS databases to identify relevant observational studies that assessed the relationship between circulating adropin levels and overweight/obesity up to September 2020. A random-effects model was used to compute the pooled weighted mean difference (WMD) with 95% confidence intervals (CI). The meta-analysis of five studies (n = 643 participants) showed that circulating adropin levels were significantly lower in the overweight/obese vs. the normal-weight participants (WMD = - 0.96 ng/ml, 95% CI = - 1.72 to - 0.19, P = 0.01; I2 = 88.4%). In subgroup analyses, lower circulating adropin levels in obese participants compared with normal-weight were observed in Asians (WMD = - 1.58 ng/ml, 95% CI = - 1.96 to - 1.21, P < 0.001; I2 = 0.00%), and in patients with metabolic disorders (WMD = - 1.26 ng/ml, 95% CI = - 1.76 to - 0.77, P < 0.001; I2 = 44.6%), respectively. Circulating adropin levels were significantly lower in overweight/obese vs. normal-weight participants, suggesting a possible role of this hormone in the development of obesity. However, the present research indicates that further studies are needed to conclusively confirm whether adropin is a viable marker of obesity. Copyright © 2021. Hellenic Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Review. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs42000-021-00331-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Soltani&issn=1109-3099&title=Hormones&atitle=Circulating+levels+of+adropin+and+overweight%2Fobesity%3A+a+systematic+review+and+meta-analysis+of+observational+studies.&volume=21&issue=1&spage=15&epage=22&date=2022&doi=10.1007%2Fs42000-021-00331-0&pmid=34897581&sid=OVID:medline
+
+<611>
+Unique Identifier
+ 34897094
+Title
+ Late-Life Obesity Associated with Tau Pathology in Cognitively Normal Individuals: The CABLE Study.
+Source
+ Journal of Alzheimer's Disease. 85(2):877-887, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang XX; Ma YH; Hu HY; Ma LZ; Tan L; Yu JT
+Authors Full Name
+ Zhang, Xiao-Xue; Ma, Ya-Hui; Hu, He-Ying; Ma, Ling-Zhi; Tan, Lan; Yu, Jin-Tai.
+Institution
+ Zhang, Xiao-Xue. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Ma, Ya-Hui. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Hu, He-Ying. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Ma, Ling-Zhi. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Tan, Lan. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Yu, Jin-Tai. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
+MeSH Subject Headings
+ Aged
+ Alzheimer Disease/cf [Cerebrospinal Fluid]
+ *Alzheimer Disease/pc [Prevention & Control]
+ *Amyloid beta-Peptides/cf [Cerebrospinal Fluid]
+ Biomarkers/cf [Cerebrospinal Fluid]
+ Body Mass Index
+ *Cognition/ph [Physiology]
+ Female
+ Humans
+ Life Style
+ Linear Models
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+ Phosphorylation
+ Risk Factors
+ *tau Proteins/cf [Cerebrospinal Fluid]
+Keyword Heading
+ Alzheimer's disease
+ biomarkers
+ body mass index
+ cerebrospinal fluid
+ obesity
+ waist circumference
+ waist-to-height ratio
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Existed evidence suggests that midlife obesity increases the risk of Alzheimer's disease (AD), while there is an inverse association between AD and obesity in late life. However, the underlying metabolic changes of AD pathological proteins attributed to obesity in two life stages were not clear.
+
+ OBJECTIVE: To investigate the associations of obesity types and obesity indices with AD biomarkers in cerebrospinal fluid (CSF) in different life stages.
+
+ METHODS: We recruited 1,051 cognitively normal individuals (61.94+/-10.29 years, 59.66%male) from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study with CSF detections for amyloid-beta 42 (Abeta42), total-tau (T-tau), and phosphorylated tau (P-tau). We utilized body mass index, waist circumference, waist-to-height ratio, and metabolic risk factors to determine human obesity types. Multiple linear models and interaction analyses were run to assess the impacts of obesity on AD biomarkers.
+
+ RESULTS: The metabolically unhealthy obesity or healthy obesity might exert a reduced tau pathology burden (p < 0.05). Individuals with overweight, general obesity, and central obesity presented lower levels of tau-related proteins in CSF than normal controls (p < 0.05). Specially, for late-life individuals, higher levels of obesity indices were associated with a lower load of tau pathology as measured by CSF T-tau and T-tau/Abeta42 (p < 0.05). No similar significant associations were observed in midlife.
+
+ CONCLUSION: Collectively, late-life general and central obesity seems to be associated with the reduced load of tau pathology, which further consolidates the favorable influence of obesity in specific life courses for AD prevention.
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Peptides). 0 (Biomarkers). 0 (MAPT protein, human). 0 (tau Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.3233%2fJAD-215351
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1387-2877&title=Journal+of+Alzheimer%27s+Disease&atitle=Late-Life+Obesity+Associated+with+Tau+Pathology+in+Cognitively+Normal+Individuals%3A+The+CABLE+Study.&volume=85&issue=2&spage=877&epage=887&date=2022&doi=10.3233%2FJAD-215351&pmid=34897094&sid=OVID:medline
+
+<612>
+Unique Identifier
+ 34889205
+Title
+ Serum markers, obesity and prostate cancer risk: results from the prostate cancer prevention trial.
+Source
+ Endocrine-Related Cancer. 29(2):99-109, 2022 01 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chau CH; Till C; Price DK; Goodman PJ; Neuhouser ML; Pollak MN; Thompson IM; Figg WD
+Author NameID
+ Figg, William D; ORCID: https://orcid.org/0000-0003-2428-5613
+Authors Full Name
+ Chau, Cindy H; Till, Cathee; Price, Douglas K; Goodman, Phyllis J; Neuhouser, Marian L; Pollak, Michael N; Thompson, Ian M; Figg, William D.
+Institution
+ Chau, Cindy H. Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
+ Till, Cathee. SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
+ Price, Douglas K. Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
+ Goodman, Phyllis J. SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
+ Neuhouser, Marian L. Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
+ Pollak, Michael N. Department of Oncology and Medicine, McGill University, Montreal, Canada.
+ Thompson, Ian M. CHRISTUS Santa Rosa Hospital Medical Center, San Antonio, Texas, USA.
+ Figg, William D. Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
+MeSH Subject Headings
+ Biomarkers
+ Case-Control Studies
+ Finasteride/tu [Therapeutic Use]
+ *Finasteride
+ Humans
+ Male
+ Obesity/co [Complications]
+ Prostatic Neoplasms/pa [Pathology]
+ *Prostatic Neoplasms
+ Risk Factors
+Keyword Heading
+ BMI
+ insulin/insulin-like growth factor-1
+ obesity
+ prostate cancer risk
+ sex steroids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Molecular mechanisms linking obesity to prostate cancer involve steroid hormone and insulin/insulin-like growth factor 1 (IGF1) pathways. We investigated the association of circulating serum markers (e.g. androgens and IGFs/IGFBPs) with BMI and in modifying the association of obesity with prostate cancer risk. Data and specimens for this nested case-control study are from the Prostate Cancer Prevention Trial, a randomized, placebo-controlled trial of finasteride for prostate cancer prevention. Presence or absence of cancer was determined by prostate biopsy. Serum samples were assayed for sex steroid hormone concentrations and IGF1 axis analytes. Logistic regression estimated odds ratio and 95% CIs for risk of overall, low-grade (Gleason 2-6), and high-grade (Gleason 7-10) cancers. We found significant associations between BMI with serum steroids and IGFs/IGFBPs; the IGF1 axis was significantly associated with several serum steroids. Serum steroid levels did not affect the association of BMI with prostate cancer risk; however, IGFBP2 and IGFs modified the association of obesity with low- and high-grade disease. While serum steroids and IGFs/IGFBPs are associated with BMI, only the IGF1 axis contributed to obesity-related prostate cancer risk. Understanding the biological mechanisms linking obesity to prostate cancer risk as it relates to circulating serum markers will aid in developing effective prostate cancer prevention strategies and treatments.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 57GNO57U7G (Finasteride).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1530%2fERC-21-0107
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chau&issn=1351-0088&title=Endocrine-Related+Cancer&atitle=Serum+markers%2C+obesity+and+prostate+cancer+risk%3A+results+from+the+prostate+cancer+prevention+trial.&volume=29&issue=2&spage=99&epage=109&date=2022&doi=10.1530%2FERC-21-0107&pmid=34889205&sid=OVID:medline
+
+<613>
+Unique Identifier
+ 34866342
+Title
+ Muscle-to-fat ratio identifies functional impairments and cardiometabolic risk and predicts outcomes: biomarkers of sarcopenic obesity.
+Source
+ Journal of Cachexia, Sarcopenia and Muscle. 13(1):368-376, 2022 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yu PC; Hsu CC; Lee WJ; Liang CK; Chou MY; Lin MH; Hsiao FY; Peng LN; Chen LK
+Author NameID
+ Chen, Liang-Kung; ORCID: https://orcid.org/0000-0002-2387-8508
+Authors Full Name
+ Yu, Pei-Chin; Hsu, Chia-Chia; Lee, Wei-Ju; Liang, Chih-Kuang; Chou, Ming-Yueh; Lin, Ming-Hsien; Hsiao, Fei-Yuan; Peng, Li-Ning; Chen, Liang-Kung.
+Institution
+ Yu, Pei-Chin. Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
+ Yu, Pei-Chin. Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Yu, Pei-Chin. Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Hsu, Chia-Chia. Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
+ Hsu, Chia-Chia. Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Hsu, Chia-Chia. Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Lee, Wei-Ju. Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Lee, Wei-Ju. Department of Geriatric Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.
+ Lee, Wei-Ju. Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, Yi-Lan, Taiwan.
+ Liang, Chih-Kuang. Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Liang, Chih-Kuang. Department of Geriatric Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.
+ Liang, Chih-Kuang. Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
+ Chou, Ming-Yueh. Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Chou, Ming-Yueh. Department of Geriatric Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.
+ Chou, Ming-Yueh. Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
+ Lin, Ming-Hsien. Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
+ Lin, Ming-Hsien. Department of Geriatric Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.
+ Hsiao, Fei-Yuan. Graduate Institute of Clinical Pharmacy, National Taiwan University, Taipei, Taiwan.
+ Hsiao, Fei-Yuan. School of Pharmacy, National Taiwan University, Taipei, Taiwan.
+ Hsiao, Fei-Yuan. Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan.
+ Peng, Li-Ning. Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
+ Peng, Li-Ning. Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Peng, Li-Ning. Department of Geriatric Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.
+ Chen, Liang-Kung. Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
+ Chen, Liang-Kung. Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
+ Chen, Liang-Kung. Department of Geriatric Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.
+ Chen, Liang-Kung. Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.
+MeSH Subject Headings
+ Adipose Tissue
+ Aged
+ Biomarkers
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Female
+ Hand Strength
+ Humans
+ Male
+ Muscles
+ Obesity/co [Complications]
+ Sarcopenia/co [Complications]
+ Sarcopenia/et [Etiology]
+ *Sarcopenia
+Keyword Heading
+ Cardiovascular disease
+ Falls
+ Muscle-to-fat ratio
+ Sarcopenia
+ Sarcopenic obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Sarcopenic obesity aims to capture the risk of functional decline and cardiometabolic diseases, but its operational definition and associated clinical outcomes remain unclear. Using data from the Longitudinal Aging Study of Taipei, this study explored the roles of the muscle-to-fat ratio (MFR) with different definitions and its associations with clinical characteristics, functional performance, cardiometabolic risk and outcomes.
+
+ METHODS: (1) Appendicular muscle mass divided by total body fat mass (aMFR), (2) total body muscle mass divided by total body fat mass (tMFR) and (3) relative appendicular skeletal muscle mass (RASM) were measured. Each measurement was categorized by the sex-specific lowest quintiles for all study participants. Clinical outcomes included all-cause mortality and fracture.
+
+ RESULTS: Data from 1060 community-dwelling older adults (mean age: 71.0 +/- 4.8 years) were retrieved for the study. Overall, 196 (34.2% male participants) participants had low RASM, but none was sarcopenic. Compared with those with high aMFR, participants with low aMFR were older (72 +/- 5.6 vs. 70.7 +/- 4.6 years, P = 0.005); used more medications (2.9 +/- 3.3 vs. 2.1 +/- 2.5, P = 0.002); had a higher body fat percentage (38 +/- 4.8% vs. 28 +/- 6.4%, P < 0.001), RASM (6.7 +/- 1.0 vs. 6.5 +/- 1.1 kg/m2 , P = 0.001), and cardiometabolic risk [fasting glucose: 105 +/- 27.5 vs. 96.8 +/- 18.7 mg/dL, P < 0.001; glycated haemoglobin (HbA1c): 6.0 +/- 0.8 vs. 5.8 +/- 0.6%, P < 0.001; triglyceride: 122.5 +/- 56.9 vs. 108.6 +/- 67.5 mg/dL, P < 0.001; high-density lipoprotein cholesterol (HDL-C): 56.2 +/- 14.6 vs. 59.8 +/- 16 mg/dL, P = 0.010]; and had worse functional performance [Montreal Cognitive Assessment (MoCA): 25.7 +/- 4.2 vs. 26.4 +/- 3.0, P = 0.143, handgrip strength: 24.7 +/- 6.7 vs. 26.1 +/- 7.9 kg, P = 0.047; gait speed: 1.8 +/- 0.6 vs. 1.9 +/- 0.6 m/s, P < 0.001]. Multivariate linear regression showed that age (beta = 0.093, P = 0.001), body mass index (beta = 0.151, P = 0.046), total percentage of body fat (beta = 0.579, P < 0001) and RASM (beta = 0.181, P = 0.016) were associated with low aMFR. Compared with those with high tMFR, participants with low tMFR were older (71.7 +/- 5.5 vs. 70.8 +/- 4.7 years, P = 0.075); used more medications (2.8 +/- 3.3 vs. 2.1 +/- 2.5, P = 0.006); had a higher body fat percentage (38.1 +/- 4.7 vs. 28 +/- 6.3%, P < 0.001), RASM (6.8 +/- 1.0 vs. 6.5 +/- 1.1 kg/m2 , P < 0.001), and cardiometabolic risk (fasting glucose: 104.8 +/- 27.6 vs. 96.9 +/- 18.7 mg/dL, P < 0.001; HbA1c: 6.1 +/- 0.9 vs. 5.8 +/- 0.6%, P < 0.001; triglyceride: 121.4 +/- 55.5 vs. 108.8 +/- 67.8 mg/dL, P < 0.001; HDL-C: 56.4 +/- 14.9 vs. 59.7 +/- 15.9 mg/dL, P = 0.021); and had worse functional performance (MoCA: 25.6 +/- 4.2 vs. 26.5 +/- 3.0, P = 0.056; handgrip strength: 24.6 +/- 6.7 vs. 26.2 +/- 7.9 kg, P = 0.017; gait speed: 1.8 +/- 0.6 vs. 1.9 +/- 0.6 m/s, P < 0.001). Low tMFR was associated with body fat percentage (beta = 0.766, P < 0.001), RASM (beta = 0.476, P < 0.001) and Mini-Nutritional Assessment (beta = -0.119, P < 0.001). Gait speed, MoCA score, fasting glucose, HbA1c and tMFR were significantly associated with adverse outcomes, and the effects of aMFR were marginal (P = 0.074).
+
+ CONCLUSIONS: Older adults identified with low MFR had unfavourable body composition, poor functional performance, high cardiometabolic risk and a high risk for the clinical outcome. Copyright © 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2fjcsm.12877
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yu&issn=2190-5991&title=Journal+of+Cachexia%2C+Sarcopenia+and+Muscle&atitle=Muscle-to-fat+ratio+identifies+functional+impairments+and+cardiometabolic+risk+and+predicts+outcomes%3A+biomarkers+of+sarcopenic+obesity.&volume=13&issue=1&spage=368&epage=376&date=2022&doi=10.1002%2Fjcsm.12877&pmid=34866342&sid=OVID:medline
+
+<614>
+Unique Identifier
+ 34865967
+Title
+ Height is Inversely Associated with Biomarkers of Intracranial Atherosclerotic Disease in Older Adults of Amerindian Ancestry: Exploring the Obesity Paradox.
+Source
+ Journal of Stroke & Cerebrovascular Diseases. 31(4):106200, 2022 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Del Brutto OH; Mera RM; Recalde BY; Perez P; Ortega-Tola J; Rumbea DA; Sedler MJ
+Authors Full Name
+ Del Brutto, Oscar H; Mera, Robertino M; Recalde, Bettsy Y; Perez, Pedro; Ortega-Tola, Jose; Rumbea, Denisse A; Sedler, Mark J.
+Institution
+ Del Brutto, Oscar H. School of Medicine, Universidad Espiritu Santo - Ecuador, Samborondon, Ecuador. Electronic address: oscardelbrutto@hotmail.com.
+ Mera, Robertino M. Department of Epidemiology, Gilead Sciences, Inc., Foster City, CA, USA.
+ Recalde, Bettsy Y. Community Center, The Atahualpa Project, Atahualpa, Ecuador.
+ Perez, Pedro. Department of Psychiatry, Mount Sinai Morningside, New York, NY, USA.
+ Ortega-Tola, Jose. Community Center, The Atahualpa Project, Atahualpa, Ecuador.
+ Rumbea, Denisse A. Community Center, The Atahualpa Project, Atahualpa, Ecuador.
+ Sedler, Mark J. Renaissance School of Medicine, Stony Brook University, New York, NY, USA.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Aged
+ Atherosclerosis/co [Complications]
+ *Atherosclerosis
+ Biomarkers
+ Humans
+ Independent Living
+ Intracranial Arteriosclerosis/co [Complications]
+ *Intracranial Arteriosclerosis
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+Keyword Heading
+ Amerindians
+ Anthropometric measurements
+ Intracranial atherosclerotic disease
+ Obesity paradox
+ Population-based study
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Various anthropometric measurements have been inversely associated with atherosclerosis, giving rise to the concept of an "obesity paradox" However, inconsistent study results make it difficult to determine the best anthropometric measurement with which to assess such inverse relationship. Height has been inversely associated with atherosclerosis and it is unlikely to be associated with unexpected biases. In this study, we aimed to assess the association between height and other anthropometric measurements and intracranial atherosclerotic disease (ICAD).
+
+ METHODS: Community-dwelling older adults enrolled in the Three Villages Study received anthropometric measurements, high-resolution head CT (to evaluate calcium content in carotid siphons) and time-of-flight MRA (to assess stenosis of large intracranial arteries). Logistic regression models were fitted to assess the independent association between each anthropometric measurements and the presence of ICAD, after adjusting for relevant confounders. Estimated adjusted proportions were used to show how increases of different anthropometric measurements impacted ICAD log odds and corresponding odds ratios.
+
+ RESULTS: A total of 581 individuals were enrolled. Height was the single variable inversely associated with ICAD at the mean of other anthropometric measurements (OR: 0.954; 95% C.I.: 0.918 - 0.991; p=0.016). Every additional cm of height reduced by 4.6% the probability of having ICAD. The significance of other anthropometric measurements vanished in multivariate models with height as an independent variable.
+
+ CONCLUSIONS: This study demonstrates a robust inverse association between height and ICAD in Amerindians and opens new avenues of research for a better understanding of the obesity paradox in diverse ethnic groups. Copyright © 2021 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.jstrokecerebrovasdis.2021.106200
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Del+Brutto&issn=1052-3057&title=Journal+of+Stroke+%26+Cerebrovascular+Diseases&atitle=Height+is+Inversely+Associated+with+Biomarkers+of+Intracranial+Atherosclerotic+Disease+in+Older+Adults+of+Amerindian+Ancestry%3A+Exploring+the+Obesity+Paradox.&volume=31&issue=4&spage=106200&epage=&date=2022&doi=10.1016%2Fj.jstrokecerebrovasdis.2021.106200&pmid=34865967&sid=OVID:medline
+
+<615>
+Unique Identifier
+ 34864598
+Title
+ Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds is associated with a risk of obesity and diabetes mellitus among Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017.
+Source
+ International Journal of Hygiene & Environmental Health. 240:113886, 2022 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee I; Park H; Kim MJ; Kim S; Choi S; Park J; Cho YH; Hong S; Yoo J; Cheon GJ; Choi K; Park YJ; Moon MK
+Authors Full Name
+ Lee, Inae; Park, Hyunwoong; Kim, Min Joo; Kim, Sunmi; Choi, Sohyeon; Park, Jeongim; Cho, Yoon Hee; Hong, Sooyeon; Yoo, Jiyoung; Cheon, Gi Jeong; Choi, Kyungho; Park, Young Joo; Moon, Min Kyong.
+Institution
+ Lee, Inae. School of Public Health, Seoul National University, Seoul, South Korea.
+ Park, Hyunwoong. Department of Laboratory Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea.
+ Kim, Min Joo. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
+ Kim, Sunmi. School of Public Health, Seoul National University, Seoul, South Korea; Chemical Safety Research Center, Korea Research Institute of Chemical Technology, Daejeon, South Korea.
+ Choi, Sohyeon. College of Natural Science, Soonchunhyang University, Asan, South Korea.
+ Park, Jeongim. College of Natural Science, Soonchunhyang University, Asan, South Korea.
+ Cho, Yoon Hee. Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, USA.
+ Hong, Sooyeon. Environmental Health Research Division, National Institute of Environmental Research, Ministry of Environment, Incheon, South Korea.
+ Yoo, Jiyoung. Environmental Health Research Division, National Institute of Environmental Research, Ministry of Environment, Incheon, South Korea.
+ Cheon, Gi Jeong. Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
+ Choi, Kyungho. School of Public Health, Seoul National University, Seoul, South Korea.
+ Park, Young Joo. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
+ Moon, Min Kyong. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Devision of Endocrinology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea. Electronic address: mkmoon@snu.ac.kr.
+MeSH Subject Headings
+ Adult
+ Biomarkers/ur [Urine]
+ Diabetes Mellitus/ci [Chemically Induced]
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus
+ Environmental Exposure/an [Analysis]
+ Environmental Health
+ Humans
+ Obesity/ep [Epidemiology]
+ Polycyclic Aromatic Hydrocarbons/ur [Urine]
+ *Polycyclic Aromatic Hydrocarbons
+ Republic of Korea/ep [Epidemiology]
+ *Volatile Organic Compounds
+Keyword Heading
+ Diabetes mellitus
+ Nonalcoholic fatty liver disease
+ Obesity
+ Polycyclic aromatic hydrocarbons
+ Volatile organic compounds
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Environmental pollutants have been known to increase the risks of not only respiratory and cardiovascular disease but also metabolic diseases such as obesity and diabetes mellitus (DM). Polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) such as benzene and toluene are major constituents of environmental pollution. In the present study, we employed the population of the Korean National Environmental Health Survey (KoNEHS) Cycle 3 conducted between 2015 and 2017, and assessed the associations of urinary biomarkers for PAHs and VOCs exposure with obesity and DM. A total of 3787 adult participants were included and the urinary concentrations of four PAH metabolites and two VOC metabolites were measured. For correcting urine dilution, a covariate-adjusted standardization method was used. The highest quartiles of urinary 2-hydroxynaphthalene (2-NAP) [OR (95% confidence interval (CI)) = 1.46 (1.13, 1.87)] and sum of PAH metabolites [OR (95% CI) = 1.45 (1.13, 1.87)] concentrations were associated with a higher risk of obesity [body mass index (BMI)>=25 kg/m2]. BMI was positively associated with urinary 2-NAP [beta (95% CI) = 0.25 (0.09, 0.41), p = 0.003] and sum of PAH metabolites [beta (95% CI) = 0.29 (0.08, 0.49), p = 0.006] concentrations. The risk of DM was increased with increasing quartile of 2-hydroxyfluorene (2-OHFlu) and trans, trans-muconic acid (t,t-MA) (p for trend<0.05 and < 0.001, respectively). The highest quartile of t,t-MA showed a significantly higher risk of DM [OR (95% CI) = 2.77 (1.74, 4.42)] and obesity [OR (95% CI) = 1.42 (1.06, 1.90)]. Urinary t,t,-MA level was positively associated with BMI [(beta (95% CI) = 0.51 (0.31, 0.71), p < 0.001] and non-alcoholic fatty liver disease index [(beta (95% CI) = 0.09 (0.06, 0.12), p < 0.001]. In conclusion, the benzene metabolites t,t-MA and PAH metabolite 2-OHFlu were associated with an increased risk of DM. Urinary biomarkers for PAHs and VOCs were positively associated with BMI in the Korean adult population. Further studies to validate these observations in other populations are warranted. Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Polycyclic Aromatic Hydrocarbons). 0 (Volatile Organic Compounds).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.ijheh.2021.113886
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=1438-4639&title=International+Journal+of+Hygiene+%26+Environmental+Health&atitle=Exposure+to+polycyclic+aromatic+hydrocarbons+and+volatile+organic+compounds+is+associated+with+a+risk+of+obesity+and+diabetes+mellitus+among+Korean+adults%3A+Korean+National+Environmental+Health+Survey+%28KoNEHS%29+2015-2017.&volume=240&issue=&spage=113886&epage=&date=2022&doi=10.1016%2Fj.ijheh.2021.113886&pmid=34864598&sid=OVID:medline
+
+<616>
+Unique Identifier
+ 34857870
+Title
+ The impact of obesity and bariatric surgery on the immune microenvironment of the endometrium.
+Source
+ International Journal of Obesity. 46(3):605-612, 2022 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Naqvi A; MacKintosh ML; Derbyshire AE; Tsakiroglou AM; Walker TDJ; McVey RJ; Bolton J; Fergie M; Bagley S; Ashton G; Pemberton PW; Syed AA; Ammori BJ; Byers R; Crosbie EJ
+Author NameID
+ Walker, Thomas D J; ORCID: http://orcid.org/0000-0003-4607-7321
+ Fergie, Martin; ORCID: http://orcid.org/0000-0002-9531-6109
+ Bagley, Steven; ORCID: http://orcid.org/0000-0002-9007-7292
+ Crosbie, Emma J; ORCID: http://orcid.org/0000-0003-0284-8630
+Authors Full Name
+ Naqvi, Anie; MacKintosh, Michelle L; Derbyshire, Abigail E; Tsakiroglou, Anna-Maria; Walker, Thomas D J; McVey, Rhona J; Bolton, James; Fergie, Martin; Bagley, Steven; Ashton, Garry; Pemberton, Philip W; Syed, Akheel A; Ammori, Basil J; Byers, Richard; Crosbie, Emma J.
+Institution
+ Naqvi, Anie. The University of Manchester Medical School, Oxford Road, Manchester, M13 9PL, UK.
+ MacKintosh, Michelle L. Division of Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9WL, UK.
+ Derbyshire, Abigail E. Division of Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9WL, UK.
+ Tsakiroglou, Anna-Maria. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
+ Walker, Thomas D J. Gynaecological Oncology Research Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, St Mary's Hospital, Oxford Road, Manchester, M13 9WL, UK.
+ McVey, Rhona J. Department of Pathology, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9WL, UK.
+ Bolton, James. Department of Pathology, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9WL, UK.
+ Fergie, Martin. Division of Informatics, Imaging & Data Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
+ Bagley, Steven. CRUK Manchester Institute, The University of Manchester, Alderley Park, Alderley Edge, SK10 4TG, UK.
+ Ashton, Garry. CRUK Manchester Institute, The University of Manchester, Alderley Park, Alderley Edge, SK10 4TG, UK.
+ Pemberton, Philip W. Department of Clinical Biochemistry, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9WL, UK.
+ Syed, Akheel A. Department of Obesity Medicine, Diabetes & Endocrinology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Stott Lane, Salford, M6 8HD, UK.
+ Syed, Akheel A. Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
+ Ammori, Basil J. Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
+ Ammori, Basil J. Department of Surgery, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Stott Lane, Salford, M6 8HD, UK.
+ Byers, Richard. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
+ Byers, Richard. Department of Pathology, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9WL, UK.
+ Crosbie, Emma J. Division of Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9WL, UK. Emma.crosbie@manchester.ac.uk.
+ Crosbie, Emma J. Gynaecological Oncology Research Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, St Mary's Hospital, Oxford Road, Manchester, M13 9WL, UK. Emma.crosbie@manchester.ac.uk.
+MeSH Subject Headings
+ *Bariatric Surgery
+ Biomarkers
+ Endometrial Neoplasms/ep [Epidemiology]
+ *Endometrial Neoplasms
+ Endometrium/im [Immunology]
+ *Endometrium
+ Female
+ Humans
+ Immunologic Surveillance
+ Interleukin-6/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+ Prospective Studies
+ Tumor Microenvironment
+ Weight Loss
+Abstract
+ BACKGROUND: The incidence of endometrial cancer is rising in parallel with the obesity epidemic. Obesity increases endometrial cancer risk and weight loss is protective, but the underlying mechanisms are incompletely understood. We hypothesise that the immune microenvironment may influence susceptibility to malignant transformation in the endometrium. The aim of this study was to measure the impact of obesity and weight loss on the immunological landscape of the endometrium.
+
+ METHODS: We conducted a prospective cohort study of women with class III obesity (body mass index, BMI >= 40 kg/m2) undergoing bariatric surgery or medically-supervised low-calorie diet. We collected blood and endometrial samples at baseline, and two and 12 months after weight loss intervention. Serum was analysed for inflammatory markers CRP, IL-6 and TNF-alpha. Multiplex immunofluorescence was used to simultaneously identify cells positive for immune markers CD68, CD56, CD3, CD8, FOXP3 and PD-1 in formalin-fixed paraffin-embedded endometrial tissue sections. Kruskal-Wallis tests were used to determine whether changes in inflammatory and immune biomarkers were associated with weight loss.
+
+ RESULTS: Forty-three women with matched serum and tissue samples at all three time points were included in the analysis. Their median age and BMI were 44 years and 52 kg/m2, respectively. Weight loss at 12 months was greater in women who received bariatric surgery (n = 37, median 63.3 kg) than low-calorie diet (n = 6, median 12.8 kg). There were significant reductions in serum CRP (p = 3.62 x 10-6, r = 0.570) and IL-6 (p = 0.0003, r = 0.459), but not TNF-alpha levels, with weight loss. Tissue immune cell densities were unchanged except for CD8+ cells, which increased significantly with weight loss (p = 0.0097, r = -0.323). Tissue CD3+ cell density correlated negatively with systemic IL-6 levels (p = 0.0376; r = -0.318).
+
+ CONCLUSION: Weight loss is associated with reduced systemic inflammation and a recruitment of protective immune cell types to the endometrium, supporting the concept that immune surveillance may play a role in endometrial cancer prevention. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41366-021-01027-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Naqvi&issn=0307-0565&title=International+Journal+of+Obesity&atitle=The+impact+of+obesity+and+bariatric+surgery+on+the+immune+microenvironment+of+the+endometrium.&volume=46&issue=3&spage=605&epage=612&date=2022&doi=10.1038%2Fs41366-021-01027-6&pmid=34857870&sid=OVID:medline
+
+<617>
+Unique Identifier
+ 34796678
+Title
+ Adiposity, related biomarkers, and type 2 diabetes after gestational diabetes: The Diabetes Prevention Program.
+Source
+ Obesity. 30(1):221-228, 2022 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wander PL; Christophi CA; Araneta MRG; Boyko EJ; Enquobahrie DA; Dabelea D; Goldberg RB; Kahn SE; Kim C; Pi-Sunyer X; Knowler WC
+Author NameID
+ Wander, Pandora L; ORCID: https://orcid.org/0000-0003-3671-1464
+ Kim, Catherine; ORCID: https://orcid.org/0000-0001-9237-0532
+Authors Full Name
+ Wander, Pandora L; Christophi, Costas A; Araneta, Maria Rosario G; Boyko, Edward J; Enquobahrie, Daniel A; Dabelea, Dana; Goldberg, Ronald B; Kahn, Steven E; Kim, Catherine; Pi-Sunyer, Xavier; Knowler, William C.
+Institution
+ Wander, Pandora L. Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
+ Wander, Pandora L. Department of Medicine, University of Washington, Seattle, Washington, USA.
+ Christophi, Costas A. Biostatistics Center, George Washington University, Rockville, Maryland, USA.
+ Araneta, Maria Rosario G. Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA.
+ Boyko, Edward J. Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
+ Boyko, Edward J. Department of Medicine, University of Washington, Seattle, Washington, USA.
+ Enquobahrie, Daniel A. Department of Epidemiology, University of Washington, Seattle, Washington, USA.
+ Dabelea, Dana. Department of Preventive Medicine and Biometrics, Colorado School of Public Health, Aurora, Colorado, USA.
+ Goldberg, Ronald B. Department of Medicine, University of Miami, Miami, Florida, USA.
+ Kahn, Steven E. Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
+ Kahn, Steven E. Department of Medicine, University of Washington, Seattle, Washington, USA.
+ Kim, Catherine. Departments of Medicine and Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.
+ Pi-Sunyer, Xavier. Division of Endocrinology, Columbia University Medical Center, New York, New York, USA.
+ Knowler, William C. National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adiposity
+ Biomarkers
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ *Diabetes Mellitus, Type 2
+ *Diabetes, Gestational
+ Female
+ Humans
+ Obesity
+ Pregnancy
+Abstract
+ OBJECTIVE: This study investigated associations of adiposity and adiposity-related biomarkers with incident type 2 diabetes (T2D) among parous women.
+
+ METHODS: Among women in the Diabetes Prevention Program (DPP) who reported a previous live birth, circulating biomarkers (leptin, adiponectin, sex hormone-binding globulin, and alanine aminotransferase; n = 1,711) were measured at enrollment (average: 12 years post partum). Visceral (VAT) and subcutaneous adipose tissue areas at the L2-L3 region and the L3-L4 region were quantified by computed tomography (n = 477). Overall and stratified (by history of gestational diabetes mellitus [GDM]) adjusted Cox proportional hazards models were fit.
+
+ RESULTS: Alanine aminotransferase, L2-L3 VAT, and L3-L4 VAT were positively associated (hazard ratio [HR] for 1-SD increases: 1.073, p = 0.024; 1.251, p = 0.009; 1.272, p = 0.004, respectively), and adiponectin concentration was inversely associated with T2D (HR 0.762, p < 0.001). Whereas leptin concentration was not associated with T2D overall, in GDM-stratified models, a 1-SD higher leptin was positively associated with risk of T2D in women without GDM (HR: 1.126, p = 0.016) and inversely in women with a history of GDM (HR: 0.776, p = 0.013, interaction p = 0.002).
+
+ CONCLUSIONS: Among parous women, alanine aminotransferase and VAT are positively associated with incident T2D, whereas adiponectin is inversely associated. Leptin is associated with higher risk of T2D in women with a history of GDM but a lower risk in women without a history of GDM. Copyright © 2021 The Obesity Society (TOS). This article has been contributed to by US Government employees and their work is in the public domain in the USA.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2foby.23291
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wander&issn=1930-7381&title=Obesity&atitle=Adiposity%2C+related+biomarkers%2C+and+type+2+diabetes+after+gestational+diabetes%3A+The+Diabetes+Prevention+Program.&volume=30&issue=1&spage=221&epage=228&date=2022&doi=10.1002%2Foby.23291&pmid=34796678&sid=OVID:medline
+
+<618>
+Unique Identifier
+ 34734482
+Title
+ Changes in OGTT-derived biomarkers in response to lifestyle intervention among Latino adolescents with obesity.
+Source
+ Pediatric Obesity. 17(4):e12867, 2022 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pena A; Kim JY; Reyes JA; Vander Wyst KB; Ayers SL; Olson ML; Williams AN; Shaibi GQ
+Author NameID
+ Pena, Armando; ORCID: https://orcid.org/0000-0002-8219-9433
+ Vander Wyst, Kiley B; ORCID: https://orcid.org/0000-0001-7182-4531
+ Shaibi, Gabriel Q; ORCID: https://orcid.org/0000-0002-6890-2903
+Authors Full Name
+ Pena, Armando; Kim, Joon Young; Reyes, Jessica A; Vander Wyst, Kiley B; Ayers, Stephanie L; Olson, Micah L; Williams, Allison N; Shaibi, Gabriel Q.
+Institution
+ Pena, Armando. Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona, USA.
+ Pena, Armando. College of Health Solutions, Arizona State University, Phoenix, Arizona, USA.
+ Kim, Joon Young. Department of Exercise Science, Syracuse University, Syracuse, New York, USA.
+ Reyes, Jessica A. School of Medicine, Indiana University, Indianapolis, Indiana, USA.
+ Vander Wyst, Kiley B. College of Graduate Studies, Midwestern University, Glendale, Arizona, USA.
+ Ayers, Stephanie L. Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, Arizona, USA.
+ Olson, Micah L. Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona, USA.
+ Olson, Micah L. Division of Pediatric Endocrinology and Diabetes, Phoenix Children's Hospital, Phoenix, Arizona, USA.
+ Williams, Allison N. Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona, USA.
+ Shaibi, Gabriel Q. Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona, USA.
+ Shaibi, Gabriel Q. College of Health Solutions, Arizona State University, Phoenix, Arizona, USA.
+ Shaibi, Gabriel Q. Division of Pediatric Endocrinology and Diabetes, Phoenix Children's Hospital, Phoenix, Arizona, USA.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ Blood Glucose
+ Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ *Diabetes Mellitus, Type 2
+ Female
+ Glucose Tolerance Test
+ Hispanic or Latino
+ Humans
+ Insulin
+ *Insulin Resistance
+ Life Style
+ Obesity/ep [Epidemiology]
+ Obesity/th [Therapy]
+Keyword Heading
+ diabetes prevention
+ exercise
+ health behaviour
+ nutrition
+ physical activity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Glucose concentrations during an oral glucose tolerance test (OGTT) have been used as biomarkers to differentiate type 2 diabetes risk phenotypes. No studies have examined changes in OGTT-glucose phenotypes following lifestyle intervention among high-risk youth.
+
+ OBJECTIVE: To examine changes in OGTT-glucose phenotypes following lifestyle intervention and to explore differences in insulin sensitivity and beta-cell function among post-intervention phenotypes.
+
+ METHODS: Latino adolescents with obesity (n = 48, age 15.4 +/- 1.0, BMI% 98.2 +/- 1.4, female 56.3%) completed a 12-week lifestyle intervention that included weekly nutrition education and physical activity. At baseline and 12 weeks, youth completed a 2-h OGTT with glucose and insulin concentrations assessed at 0', 30', 60', 90' and 120'. Glucose concentrations during the OGTT were used to identify biomarkers, 1-h glucose, glucose response curve and time to glucose peak. Using these respective biomarkers, high-risk (1-h glucose >= 155 mg/dl, Monophasic, Late Peak) and lower-risk phenotypes (1-h glucose < 155 mg/dl, Biphasic, Early Peak) were categorized. Insulin sensitivity was estimated by whole-body insulin sensitivity index (WBISI) and beta-cell function by oral disposition index (oDI).
+
+ RESULTS: Following intervention, the prevalence of Monophasic phenotypes decreased from 81% to 67% (p = 0.048) and 1-h glucose >= 155 mg/dl from 38% to 10% (p = 0.054). Although Late Peak phenotypes did not significantly change (from 58% to 29%, p = 0.200), Early Peak phenotypes at post-intervention demonstrated significantly higher WBISI compared to Late Peak (2.3 +/- 0.1 vs 1.7 +/- 0.2, p = 0.023).
+
+ CONCLUSIONS: OGTT-glucose phenotypes improve following lifestyle intervention among high-risk youth. These findings further support their potential utility as clinical biomarkers to identify diabetes risk and risk reduction in youth. Copyright © 2021 World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1111%2fijpo.12867
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pena&issn=2047-6302&title=Pediatric+Obesity&atitle=Changes+in+OGTT-derived+biomarkers+in+response+to+lifestyle+intervention+among+Latino+adolescents+with+obesity.&volume=17&issue=4&spage=e12867&epage=&date=2022&doi=10.1111%2Fijpo.12867&pmid=34734482&sid=OVID:medline
+
+<619>
+Unique Identifier
+ 34702086
+Title
+ Effects of Lifestyle Intervention on Inflammatory Markers and Waist Circumference in Overweight/Obese Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
+Source
+ Biological Research for Nursing. 24(1):94-105, 2022 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rahimi GRM; Yousefabadi HA; Niyazi A; Rahimi NM; Alikhajeh Y
+Author NameID
+ Rahimi, Gholam Rasul Mohammad; ORCID: https://orcid.org/0000-0002-8159-2065
+ Rahimi, Nasser Mohammad; ORCID: https://orcid.org/0000-0003-2316-9100
+Authors Full Name
+ Rahimi, Gholam Rasul Mohammad; Yousefabadi, Heidar Alizaei; Niyazi, Arghavan; Rahimi, Nasser Mohammad; Alikhajeh, Yaser.
+Institution
+ Rahimi, Gholam Rasul Mohammad. Department of Sports Sciences, Vahdat Institute of Higher Education, Torbat-e-Jam, Iran.
+ Yousefabadi, Heidar Alizaei. Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.
+ Niyazi, Arghavan. Sanabad Institution of Higher Education Mashhad, Mashhad, Iran.
+ Rahimi, Nasser Mohammad. Department of Sport Sciences, Imam Reza International University, Mashhad, Iran.
+ Alikhajeh, Yaser. Department of Physical Education and Sports Sciences, Faculty of Educational Science and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Humans
+ Inflammation
+ Life Style
+ Metabolic Syndrome/th [Therapy]
+ *Metabolic Syndrome
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Overweight/co [Complications]
+ Overweight/th [Therapy]
+ *Overweight
+ Randomized Controlled Trials as Topic
+ Waist Circumference
+Keyword Heading
+ abdominal adiposity
+ dietary advice
+ inflammation
+ metabolic syndrome
+ physical activity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Physical inactivity and an imbalanced diet could lead to some cardio metabolic risk factors.
+
+ OBJECTIVE: The objective of this meta-analysis was to investigate the effects of lifestyle modification on inflammatory indicators and waist circumference (WC) in overweight/obese subjects with metabolic syndrome (MS).
+
+ DATA SOURCES: A systematic search was conducted in PubMed, CINAHL, MEDLINE, Cochrane, Google Scholar, and Web of Science.
+
+ STUDY SELECTION: The selection criteria were randomized controlled trials (RCTs) investigating the effects of lifestyle interventions on inflammation and WC from inception to 20 December 2020. The weighted mean difference (WMD) and 95% confidence interval (CI) between interventions were computed using a random or fixed-effects model.
+
+ RESULTS: Six RCTs (including 1246 MS patients who had, on average, overweight/obesity) met all inclusion criteria. Interventions lasted 6 to 12 months (2-5 sessions per week). Lifestyle intervention significantly reduced C-reactive protein (WMD: -0.52 mg/ml, 95% CI: -0.72, -0.33), IL-6 (WMD: -0.50 pg/ml, 95% CI: -0.56, -0.45), and increased adiponectin (WMD: 0.81 microg/ml, 95% CI, 0.64, 0.98). Moreover, lifestyle modification significantly decreased WC (WMD: -3.12 cm, 95% CI, -4.61, -1.62).
+
+ CONCLUSION: Our findings provide evidence that lifestyle alterations, including physical activity and diet, can lead to significant improvement in abdominal obesity, measured by WC and some inflammation markers among overweight/obese individuals with MS. Further high-quality research is needed to clarify the mechanisms underlying the effect of such interventions on this population's inflammatory markers.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1177%2f10998004211044754
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rahimi&issn=1099-8004&title=Biological+Research+for+Nursing&atitle=Effects+of+Lifestyle+Intervention+on+Inflammatory+Markers+and+Waist+Circumference+in+Overweight%2FObese+Adults+With+Metabolic+Syndrome%3A+A+Systematic+Review+and+Meta-Analysis+of+Randomized+Controlled+Trials.&volume=24&issue=1&spage=94&epage=105&date=2022&doi=10.1177%2F10998004211044754&pmid=34702086&sid=OVID:medline
+
+<620>
+Unique Identifier
+ 34668255
+Title
+ Lifetime obesity trends are associated with subclinical myocardial injury: The Trondelag health study.
+Source
+ Journal of Internal Medicine. 291(3):317-326, 2022 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lyngbakken MN; de Lemos JA; Hveem K; Rosjo H; Omland T
+Author NameID
+ Lyngbakken, Magnus Nakrem; ORCID: https://orcid.org/0000-0002-5994-9304
+ Rosjo, Helge; ORCID: https://orcid.org/0000-0003-2114-3134
+Authors Full Name
+ Lyngbakken, Magnus Nakrem; de Lemos, James A; Hveem, Kristian; Rosjo, Helge; Omland, Torbjorn.
+Institution
+ Lyngbakken, Magnus Nakrem. Department of Cardiology, Akershus University Hospital, Lorenskog, Norway.
+ Lyngbakken, Magnus Nakrem. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
+ de Lemos, James A. Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
+ Hveem, Kristian. HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
+ Hveem, Kristian. Levanger Hospital, Nord-Trondelag Hospital Trust, Levanger, Norway.
+ Rosjo, Helge. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
+ Rosjo, Helge. Division of Research and Innovation, Akershus University Hospital, Lorenskog, Norway.
+ Omland, Torbjorn. Department of Cardiology, Akershus University Hospital, Lorenskog, Norway.
+ Omland, Torbjorn. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Female
+ Heart Failure/co [Complications]
+ *Heart Failure
+ Humans
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Odds Ratio
+ Troponin I
+ Troponin T
+Keyword Heading
+ cardiovascular risk factors
+ epidemiology
+ obesity
+ troponin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is associated with subclinical myocardial injury as quantified by concentrations of cardiac troponin T, but whether lifetime excess weight history is associated with increased concentrations of cardiac troponin I (cTnI) and how indices of abdominal adiposity and glycemic dysregulation affect these associations remain unclear.
+
+ METHODS: We analyzed cTnI with a high-sensitivity assay in 9739 participants in the Trondelag Health (HUNT) Study at study visit 4 (2017-2019). BMI was assessed at study Visit 1 (1984-1986), 2 (1995-1997), 3 (2006-2008), and 4.
+
+ RESULTS: Median age at visit 4 was 68.7 years and 59% were women. Concentrations of cTnI were detectable in 84.1% of study participants, with a median of 2.5 (1.5-4.5 ng/L). We identified three clusters of BMI trajectories from visit 1 to 4, (1) stable normal weight, (2) stable overweight, and (3) stable obesity. Participants in clusters 2 and 3 were at increased risk of elevated concentrations of cTnI at visit 4 (odds ratio 1.27, 95% CI 1.09-1.47, and odds ratio 1.70, 95% CI 1.33-2.17, p for trend <0.001). Participants in cluster 3 had 22.0 (95% CI 14.1-29.9) higher concentrations of cTnI compared to participants in cluster 1 (p for trend <0.001). Dysregulated glucose metabolism and abdominal obesity did not influence our results.
+
+ CONCLUSIONS: Individuals with stable overweight or obesity are at increased risk of subclinical myocardial injury, independently of glycemic dysregulation and abdominal adiposity. Our data support a direct detrimental effect of long-standing obesity on cardiovascular health. Copyright © 2021 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Troponin I). 0 (Troponin T).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1111%2fjoim.13391
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lyngbakken&issn=0954-6820&title=Journal+of+Internal+Medicine&atitle=Lifetime+obesity+trends+are+associated+with+subclinical+myocardial+injury%3A+The+Trondelag+health+study.&volume=291&issue=3&spage=317&epage=326&date=2022&doi=10.1111%2Fjoim.13391&pmid=34668255&sid=OVID:medline
+
+<621>
+Unique Identifier
+ 34661844
+Title
+ Vitamin D mediates the association between acrylamide hemoglobin biomarkers and obesity.
+Source
+ Environmental Science & Pollution Research. 29(12):17162-17172, 2022 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yin T; Xu F; Shi S; Liao S; Tang X; Zhang H; Zhou Y; Li X
+Author NameID
+ Li, Xinli; ORCID: http://orcid.org/0000-0002-7889-6359
+Authors Full Name
+ Yin, Ting; Xu, Fang; Shi, Shi; Liao, Shengen; Tang, Xiaosu; Zhang, Haifeng; Zhou, Yanli; Li, Xinli.
+Institution
+ Yin, Ting. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
+ Xu, Fang. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
+ Shi, Shi. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
+ Liao, Shengen. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
+ Tang, Xiaosu. Jiangxi Environmental Engineering Vocational College, Zhangong district, Ganzhou city, Jiangxi, 341000, China.
+ Zhang, Haifeng. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
+ Zhang, Haifeng. Gusu School, Nanjing Medical University, Suzhou, 215002, China.
+ Zhang, Haifeng. Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215002, China.
+ Zhou, Yanli. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China. zhyl88@qq.com.
+ Li, Xinli. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China. xinli3267@njmu.edu.cn.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Acrylamide/to [Toxicity]
+ *Acrylamide
+ Adolescent
+ Adult
+ Biomarkers
+ Epoxy Compounds
+ Hemoglobins/an [Analysis]
+ Humans
+ Nutrition Surveys
+ Obesity
+ *Vitamin D
+Keyword Heading
+ Acrylamide
+ Mediation analysis
+ Obesity
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Mediation analysis aims to discover the role of intermediate variables from exposure to disease. The current study was performed to evaluate how vitamin D mediates the association between acrylamide hemoglobin biomarkers and obesity. Data were collected on 10,377 adults participating in the National Health and Nutrition Examination Survey (NHANES) 2003-2006 and 2013-2014 aged >= 18 years. Obesity was assessed through body mass index and abdominal circumference measurements. Generalized linear and restricted cubic spline (RCS) regression were used to estimate the association between vitamin D and acrylamide hemoglobin biomarkers, and the mediation effect of vitamin D was also discussed. After adjusting for potentially confounding factors, vitamin D had strong negative associations with serum concentrations of acrylamide hemoglobin adducts (HbAA, HbGA, and HbAA + HbGA). The RCS plots demonstrated that vitamin D was inversely and nonlinearly associated with HbAA and HbAA + HbGA while inversely and linearly associated with HbGA, and also a striking difference when vitamin D was lower than 60 nmol/L. Mediation analysis suggested that a negative correlation between acrylamide and obesity was mediated by vitamin D. The current study is expected to offer a fresh perspective on reducing the toxicity of acrylamide. Copyright © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Epoxy Compounds). 0 (Hemoglobins). 1406-16-2 (Vitamin D). 20R035KLCI (Acrylamide).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs11356-021-16798-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yin&issn=0944-1344&title=Environmental+Science+%26+Pollution+Research&atitle=Vitamin+D+mediates+the+association+between+acrylamide+hemoglobin+biomarkers+and+obesity.&volume=29&issue=12&spage=17162&epage=17172&date=2022&doi=10.1007%2Fs11356-021-16798-8&pmid=34661844&sid=OVID:medline
+
+<622>
+Unique Identifier
+ 34625660
+Title
+ Upregulated miR-200c is associated with downregulation of the functional receptor for severe acute respiratory syndrome coronavirus 2 ACE2 in individuals with obesity.
+Source
+ International Journal of Obesity. 46(1):238-241, 2022 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bellae Papannarao J; Schwenke DO; Manning P; Katare R
+Author NameID
+ Katare, Rajesh; ORCID: http://orcid.org/0000-0001-5419-7935
+Authors Full Name
+ Bellae Papannarao, Jayanthi; Schwenke, Daryl O; Manning, Patrick; Katare, Rajesh.
+Institution
+ Bellae Papannarao, Jayanthi. Department of Physiology-HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, 9010, New Zealand.
+ Schwenke, Daryl O. Department of Physiology-HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, 9010, New Zealand.
+ Manning, Patrick. Department of Medicine, Otago Medical School, University of Otago, Dunedin, 9010, New Zealand.
+ Katare, Rajesh. Department of Physiology-HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, 9010, New Zealand. rajesh.katare@otago.ac.nz.
+MeSH Subject Headings
+ Adult
+ Angiotensin-Converting Enzyme 2/bl [Blood]
+ *Angiotensin-Converting Enzyme 2/me [Metabolism]
+ Biomarkers
+ COVID-19
+ Disease Susceptibility
+ Down-Regulation
+ Female
+ Humans
+ MicroRNAs/bl [Blood]
+ *MicroRNAs/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Risk Factors
+ *SARS-CoV-2/me [Metabolism]
+ Up-Regulation
+Abstract
+ Obesity is a risk factor for coronavirus disease 2019 (COVID-19) infection, with studies demonstrating the prevalence of individuals with obesity admitted with COVID-19 ranging between 30 and 60%. We determined whether early changes in microRNAs (miRNAs) are associated with dysregulation of angiotensin-converting enzyme 2 (ACE2), the specific functional receptor for severe acute respiratory syndrome coronavirus 2. ACE2 is a membrane-bound enzyme that catalyzes the conversion of angiotensin II to angiotensin 1-7 the latter having cardioprotective and vasorelaxation effects. Quantitative real-time PCR analysis of plasma samples for circulating miRNAs showed upregulation of miR-200c and miR-let-7b in otherwise healthy individuals with obesity. This was associated with significant downregulation of ACE2, a direct target for both miRNAs, in individuals with obesity. Correlation analysis confirmed a significant negative correlation between ACE2 and both the miRNAs. Studies showed that despite being the functional receptor, inhibition/downregulation of ACE2 did not reduce the severity of COVID-19 infection. In contrast, increased angiotensin II following inhibition of ACE2 may increase the severity of the disease. Taken together, our novel results identify that upregulation of miR-200c may increase the susceptibility of individuals with obesity to COVID-19. Considering miRNA are the earliest molecular regulators, the level of circulating miR-200c could be a potential biomarker in the early identification of those at the risk of severe COVID-19. Copyright © 2021. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN200 microRNA, human). 0 (MicroRNAs). EC 3-4-17-23 (ACE2 protein, human). EC 3-4-17-23 (Angiotensin-Converting Enzyme 2).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41366-021-00984-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bellae+Papannarao&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Upregulated+miR-200c+is+associated+with+downregulation+of+the+functional+receptor+for+severe+acute+respiratory+syndrome+coronavirus+2+ACE2+in+individuals+with+obesity.&volume=46&issue=1&spage=238&epage=241&date=2022&doi=10.1038%2Fs41366-021-00984-2&pmid=34625660&sid=OVID:medline
+
+<623>
+Unique Identifier
+ 34599748
+Title
+ Clinical epigenetics and restoring of metabolic health in severely obese patients undergoing batriatric and metabolic surgery. [Review]
+Source
+ Updates in Surgery. 74(2):431-438, 2022 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Faenza M; Benincasa G; Docimo L; Nicoletti GF; Napoli C
+Author NameID
+ Benincasa, Giuditta; ORCID: http://orcid.org/0000-0002-7552-3522
+Authors Full Name
+ Faenza, Mario; Benincasa, Giuditta; Docimo, Ludovico; Nicoletti, Giovanni Francesco; Napoli, Claudio.
+Institution
+ Faenza, Mario. Multidisciplinary Department of Medical, Surgical and Dental Sciences, Plastic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Benincasa, Giuditta. Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vanvitelli", Naples, Italy. giuditta.benincasa@unicampania.it.
+ Docimo, Ludovico. Division of General, Mininvasive and Bariatric Surgery, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80100, Naples, Italy.
+ Nicoletti, Giovanni Francesco. Multidisciplinary Department of Medical, Surgical and Dental Sciences, Plastic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Napoli, Claudio. Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vanvitelli", Naples, Italy.
+ Napoli, Claudio. Clinical Department of Internal Medicine and Specialistics, Division of Clinical Immunology, Transfusion Medicine and Transplant Immunology, AOU University of Campania "Luigi Vanvitelli", Naples, Italy.
+MeSH Subject Headings
+ Adaptor Proteins, Signal Transducing/ge [Genetics]
+ Adaptor Proteins, Signal Transducing/me [Metabolism]
+ Alpha-Ketoglutarate-Dependent Dioxygenase FTO/ge [Genetics]
+ Alpha-Ketoglutarate-Dependent Dioxygenase FTO/me [Metabolism]
+ *Bariatric Surgery
+ Biomarkers
+ Epigenesis, Genetic
+ Female
+ *Gastric Bypass
+ Humans
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Obesity/su [Surgery]
+ Obesity, Morbid/co [Complications]
+ Obesity, Morbid/ge [Genetics]
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+Keyword Heading
+ Bariatric and metabolic surgery
+ Epigenetics
+ Obesity
+ Precision medicine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Epigenetic-sensitive mechanisms, mainly DNA methylation, mirror the relationship between environmental and genetic risk factors able to affect the sensitiveness to development of obesity and its comorbidities. Bariatric and metabolic surgery may reduce obesity-related cardiovascular risk through tissue-specific DNA methylation changes. Among the most robust results, differential promoter methylation of ACACA, CETP, CTGF, S100A8, and S100A9 genes correlated significantly with the levels of mRNA before and after gastric bypass surgery (RYGB) in obese women. Additionally, promoter hypermethylation of NFKB1 gene was significantly associated with reduced blood pressure in obese patients after RYGB suggesting useful non-invasive biomarkers. Of note, sperm-related DNA methylation signatures of genes regulating the central control of appetite, such as MC4R, BDNF, NPY, and CR1, and other genes including FTO, CHST8, and SH2B1 were different in obese patients as compared to non-obese subjects and patients who lost weight after RYGB surgery. Importantly, transgenerational studies provided relevant evidence of the potential effect of bariatric and metabolic surgery on DNA methylation. For example, peripheral blood biospecimens isolated from siblings born from obese mothers before bariatric surgery showed different methylation signatures in the insulin receptor and leptin signaling axis as compared to siblings born from post-obese mothers who underwent surgery. This evidence suggests that bariatric and metabolic surgery of mothers may affect the epigenetic profiles of the offspring with potential implication for primary prevention of severe obesity. We update on tissue-specific epigenetic signatures as potential mechanisms underlying the restoration of metabolic health after surgery suggesting useful predictive biomarkers. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Adaptor Proteins, Signal Transducing). 0 (Biomarkers). 0 (SH2B1 protein, human). EC 1-14-11-33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO). EC 1-14-11-33 (FTO protein, human).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs13304-021-01162-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Faenza&issn=2038-131X&title=Updates+in+Surgery&atitle=Clinical+epigenetics+and+restoring+of+metabolic+health+in+severely+obese+patients+undergoing+batriatric+and+metabolic+surgery.&volume=74&issue=2&spage=431&epage=438&date=2022&doi=10.1007%2Fs13304-021-01162-9&pmid=34599748&sid=OVID:medline
+
+<624>
+Unique Identifier
+ 34562443
+Title
+ The Prevalence of Elevated Alanine Aminotransferase Levels Meeting Clinical Action Thresholds in Children with Obesity in Primary Care Practice.
+Source
+ Journal of Pediatrics. 240:280-283, 2022 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu SJ; Darbinian JA; Schwimmer JB; Yu EL; Ramalingam ND; Greenspan LC; Lo JC
+Authors Full Name
+ Wu, Stephanie J; Darbinian, Jeanne A; Schwimmer, Jeffrey B; Yu, Elizabeth L; Ramalingam, Nirmala D; Greenspan, Louise C; Lo, Joan C.
+Institution
+ Wu, Stephanie J. Department of Medicine, Kaiser Permanente Oakland Medical Center, Oakland, CA.
+ Darbinian, Jeanne A. Division of Research, Kaiser Permanente Northern California, Oakland, CA.
+ Schwimmer, Jeffrey B. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
+ Yu, Elizabeth L. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
+ Ramalingam, Nirmala D. Department of Medicine, Kaiser Permanente Oakland Medical Center, Oakland, CA.
+ Greenspan, Louise C. Kaiser Permanente San Francisco Medical Center, San Francisco, CA; The Permanente Medical Group, Oakland, CA.
+ Lo, Joan C. Division of Research, Kaiser Permanente Northern California, Oakland, CA; The Permanente Medical Group, Oakland, CA.
+MeSH Subject Headings
+ Adolescent
+ *Alanine Transaminase/bl [Blood]
+ Biomarkers/bl [Blood]
+ Child
+ Female
+ Humans
+ Male
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Prevalence
+Keyword Heading
+ ALT
+ NAFLD
+ alanine aminotransferase
+ children
+ ethnicity
+ nonalcoholic fatty liver disease
+ obesity
+ race
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Using a clinically actionable threshold for alanine aminotransferase to define suspected nonalcoholic fatty liver disease in US children with obesity, the risk of suspected nonalcoholic fatty liver disease was highest for Asian and Hispanic race/ethnicity, male sex, and severe obesity. Copyright © 2021 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.jpeds.2021.09.033
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=0022-3476&title=Journal+of+Pediatrics&atitle=The+Prevalence+of+Elevated+Alanine+Aminotransferase+Levels+Meeting+Clinical+Action+Thresholds+in+Children+with+Obesity+in+Primary+Care+Practice.&volume=240&issue=&spage=280&epage=283&date=2022&doi=10.1016%2Fj.jpeds.2021.09.033&pmid=34562443&sid=OVID:medline
+
+<625>
+Unique Identifier
+ 34537381
+Title
+ Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA. [Review]
+Source
+ Osteoarthritis & Cartilage. 30(4):501-515, 2022 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Batushansky A; Zhu S; Komaravolu RK; South S; Mehta-D'souza P; Griffin TM
+Authors Full Name
+ Batushansky, A; Zhu, S; Komaravolu, R K; South, S; Mehta-D'souza, P; Griffin, T M.
+Institution
+ Batushansky, A. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA. Electronic address: Albert-Batushansky@omrf.org.
+ Zhu, S. Department of Biomedical Sciences, Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, 45701, USA. Electronic address: zhus1@ohio.edu.
+ Komaravolu, R K. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA. Electronic address: Ravi-Komaravolu@omrf.org.
+ South, S. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA. Electronic address: Sanique-South@omrf.org.
+ Mehta-D'souza, P. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA. Electronic address: Padmaja-Mehta-Dsouza@omrf.org.
+ Griffin, T M. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA; Reynolds Oklahoma Center on Aging, Department of Biochemistry and Molecular Biology, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA; Veterans Affairs Medical Center, Oklahoma City, OK, 73104, USA. Electronic address: Tim-Griffin@omrf.org.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Cartilage/me [Metabolism]
+ Disease Progression
+ Female
+ Humans
+ Inflammation/me [Metabolism]
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Osteoarthritis, Knee/co [Complications]
+ Osteoarthritis, Knee/et [Etiology]
+ *Osteoarthritis, Knee
+Keyword Heading
+ Body mass index
+ Metabolic syndrome
+ Metabolomics
+ Metaflammation
+ Osteoarthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for biomechanical reasons. Here we provide an additional perspective by discussing how obesity also increases OA risk by altering metabolism and inflammation.
+
+ DESIGN: This narrative review is presented in four sections: 1) metabolic syndrome and OA, 2) metabolic biomarkers of OA, 3) evidence for dysregulated chondrocyte metabolism in OA, and 4) metabolic inflammation: joint tissue mediators and mechanisms.
+
+ RESULTS: Metabolic syndrome and its components are strongly associated with OA. However, evidence for a causal relationship is context dependent, varying by joint, gender, diagnostic criteria, and demographics, with additional environmental and genetic interactions yet to be fully defined. Importantly, some aspects of the etiology of obesity-induced OA appear to be distinct between men and women, especially regarding the role of adipose tissue. Metabolomic analyses of serum and synovial fluid have identified potential diagnostic biomarkers of knee OA and prognostic biomarkers of disease progression. Connecting these biomarkers to cellular pathophysiology will require future in vivo studies of joint tissue metabolism. Such studies will help reveal when a metabolic process or a metabolite itself is a causal factor in disease progression. Current evidence points towards impaired chondrocyte metabolic homeostasis and metabolic-immune dysregulation as likely factors connecting obesity to the increased risk of OA.
+
+ CONCLUSIONS: A deeper understanding of how obesity alters metabolic and inflammatory pathways in synovial joint tissues is expected to provide new therapeutic targets and an improved definition of "metabolic" and "obesity" OA phenotypes. Copyright Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S.. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.joca.2021.06.013
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Batushansky&issn=1063-4584&title=Osteoarthritis+%26+Cartilage&atitle=Fundamentals+of+OA.+An+initiative+of+Osteoarthritis+and+Cartilage.+Obesity+and+metabolic+factors+in+OA.&volume=30&issue=4&spage=501&epage=515&date=2022&doi=10.1016%2Fj.joca.2021.06.013&pmid=34537381&sid=OVID:medline
+
+<626>
+Unique Identifier
+ 34536157
+Title
+ Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance. [Review]
+Source
+ Inflammation. 45(1):31-44, 2022 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Mansoori L; Al-Jaber H; Prince MS; Elrayess MA
+Author NameID
+ Elrayess, Mohamed A; ORCID: http://orcid.org/0000-0003-3803-4604
+Authors Full Name
+ Al-Mansoori, Layla; Al-Jaber, Hend; Prince, Mohammad Shoaib; Elrayess, Mohamed A.
+Institution
+ Al-Mansoori, Layla. Biomedical Research Center, Qatar University, Doha, Qatar.
+ Al-Jaber, Hend. Biomedical Research Center, Qatar University, Doha, Qatar.
+ Prince, Mohammad Shoaib. Department of Sports and Wellness, College of North Atlantic Qatar (CNAQ), Doha, Qatar.
+ Elrayess, Mohamed A. Biomedical Research Center, Qatar University, Doha, Qatar. m.elrayess@qu.edu.qa.
+MeSH Subject Headings
+ *Adipogenesis/ph [Physiology]
+ *Adipokines/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ *Cytokines/me [Metabolism]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ *Intercellular Signaling Peptides and Proteins/me [Metabolism]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+Keyword Heading
+ IR
+ adipogenesis
+ adipokines
+ cytokines
+ growth factors
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity, manifested by increased adiposity, represents a main cause of morbidity in the developed countries, causing increased risk of insulin resistance and type 2 diabetes mellitus. Recruitment of macrophages and activation of innate immunity represent the initial insult, which can be further exacerbated through secretion of chemokines and adipocytokines from activated macrophages and other cells within the adipose tissue. These events can impact adipogenesis, causing dysfunction of the adipose tissue and increased risk of insulin resistance. Various factors mediate adiposity and related insulin resistance including inflammatory and non-inflammatory factors such as pro and anti-inflammatory cytokines, adipokines and growth factors. In this review we will discuss the role of these factors in adipogenesis and development of insulin resistance and type 2 diabetes mellitus in the context of obesity. Understanding the molecular mechanisms that mediate adipogenesis and insulin resistance could help the development of novel therapeutic strategies for individuals at higher risk of insulin resistance and type 2 diabetes mellitus. Copyright © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cytokines). 0 (Intercellular Signaling Peptides and Proteins).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2fs10753-021-01559-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Mansoori&issn=0360-3997&title=Inflammation&atitle=Role+of+Inflammatory+Cytokines%2C+Growth+Factors+and+Adipokines+in+Adipogenesis+and+Insulin+Resistance.&volume=45&issue=1&spage=31&epage=44&date=2022&doi=10.1007%2Fs10753-021-01559-z&pmid=34536157&sid=OVID:medline
+
+<627>
+Unique Identifier
+ 34515121
+Title
+ High-Fat Diet-Induced Obesity Aggravates Food Allergy by Intestinal Barrier Destruction and Inflammation.
+Source
+ International Archives of Allergy & Immunology. 183(1):80-92, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gu Y; Guo X; Sun S; Che H
+Authors Full Name
+ Gu, Yanjun; Guo, Xiaoya; Sun, Shanfeng; Che, Huilian.
+Institution
+ Gu, Yanjun. Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China, yanjunngu@126.com.
+ Guo, Xiaoya. Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
+ Sun, Shanfeng. Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
+ Che, Huilian. Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cytokines/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ Disease Susceptibility
+ Female
+ *Food Hypersensitivity/et [Etiology]
+ *Food Hypersensitivity/me [Metabolism]
+ Food Hypersensitivity/pa [Pathology]
+ *Gastroenteritis/et [Etiology]
+ *Gastroenteritis/me [Metabolism]
+ Gastroenteritis/pa [Pathology]
+ Immunohistochemistry
+ *Intestinal Mucosa/im [Immunology]
+ *Intestinal Mucosa/me [Metabolism]
+ Intestinal Mucosa/pa [Pathology]
+ Mice
+ NF-kappa B/me [Metabolism]
+ *Obesity/co [Complications]
+ Obesity/et [Etiology]
+ PPAR gamma
+ T-Lymphocyte Subsets/im [Immunology]
+ T-Lymphocyte Subsets/me [Metabolism]
+Keyword Heading
+ Food allergy
+ Intestinal barrier
+ Intestinal immunity
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: The increase in high-fat diet (HFD)-induced obesity and food allergy leads to an assumption that the 2 are related. This study aims to (1) systematic verification of HFD-induced obesity aggravates food allergy and (2) explore the correlation and molecular mechanisms of HFD-induced obesity promotes food allergy.
+
+ METHODS: Female BALB/c mice are divided into the control group (control), the ovalbumin (OVA)-sensitized group (OVA), the HFD-induced obesity group (HFD), and HFD-induced allergic obesity group (HFD + OVA).
+
+ RESULTS: In vivo data showed that HFD feed enhance clinical symptoms and intestinal mucosa villi shed on allergic mice. Moreover, we found that HFD and OVA irritation enhanced levels of mast cell degranulation and Th2 humoral response. Additionally, Western blot analysis showed the potentiation of peroxisome proliferator-activated receptor gamma (PPAR gamma) remarkably reduced on intestinal in HFD and OVA group, thereby inhibiting the expression of nuclear factor kappa B (NF-kappaB)/PPAR gamma signal the phosphorylation of NF-kappaB P65.
+
+ CONCLUSIONS: Overall, our results suggest that HFD-induced obesity is a potential risk factor for food allergy, which related to intestinal barrier destruction and inflammation through the PPAR gamma/NF-kappaB signaling pathway. Copyright © 2021 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (NF-kappa B). 0 (PPAR gamma).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1159%2f000517866
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gu&issn=1018-2438&title=International+Archives+of+Allergy+%26+Immunology&atitle=High-Fat+Diet-Induced+Obesity+Aggravates+Food+Allergy+by+Intestinal+Barrier+Destruction+and+Inflammation.&volume=183&issue=1&spage=80&epage=92&date=2022&doi=10.1159%2F000517866&pmid=34515121&sid=OVID:medline
+
+<628>
+Unique Identifier
+ 34473317
+Title
+ The Effects of Exercise on Lipid Biomarkers. [Review]
+Source
+ Methods in Molecular Biology. 2343:93-117, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mendoza MVF; Kachur SM; Lavie CJ
+Authors Full Name
+ Mendoza, Michael Vaughn F; Kachur, Sergey M; Lavie, Carl J.
+Institution
+ Mendoza, Michael Vaughn F. Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines.
+ Kachur, Sergey M. Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA.
+ Kachur, Sergey M. Department of Medicine, University of Central Florida School of Medicine, Orlando, FL, USA.
+ Lavie, Carl J. Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA. clavie@ochsner.org.
+MeSH Subject Headings
+ *Atherosclerosis
+ Biomarkers
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Cholesterol, LDL
+ *Dyslipidemias
+ *Exercise
+ Humans
+ Obesity
+Keyword Heading
+ C-reactive protein
+ Cardiovascular diseases
+ Dyslipidemia
+ Exercise therapy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The World Health Organization has declared obesity to be a global epidemic that increases cardiovascular disease (CVD) mortality risk factors, such as hypertension, diabetes, dyslipidemia, and atherosclerosis. The increasing ratio of time spent in sedentary activities to that spent performing physically demanding tasks increases the trends to obesity and susceptibility to these risk factors. Dyslipidemia is the foundation of atherosclerotic buildup and lipoproteins serve as cofactors to the inflammatory processes that destabilize plaques. Increasing cardiorespiratory fitness and muscular strength helps attenuate concentrations of low-density lipoproteins (LDLs), such as LDL cholesterol, and increase levels of high-density lipoprotein cholesterol, as well as reduce proprotein convertase subtilisin kexin type 9 expression. Effects of physical activity on the inflammatory pathways of atherosclerosis, specifically C-reactive protein, are more closely related to reducing the levels of adiposity in tandem with increasing fitness, than with exercise training alone. The purpose of this review is to describe the physiology of dyslipidemia and relate it to CVD and exercise therapies. Copyright © 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1007%2f978-1-0716-1558-4_6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mendoza&issn=1064-3745&title=Methods+in+Molecular+Biology&atitle=The+Effects+of+Exercise+on+Lipid+Biomarkers.&volume=2343&issue=&spage=93&epage=117&date=2022&doi=10.1007%2F978-1-0716-1558-4_6&pmid=34473317&sid=OVID:medline
+
+<629>
+Unique Identifier
+ 34431493
+Title
+ LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 107(1):e57-e70, 2022 01 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rader DJ; Maratos-Flier E; Nguyen A; Hom D; Ferriere M; Li Y; Kompa J; Martic M; Hinder M; Basson CT; Yowe D; Diener J; Goldfine AB
+Author NameID
+ Rader, Daniel J; ORCID: https://orcid.org/0000-0002-9245-9876
+ Maratos-Flier, Eleftheria; ORCID: https://orcid.org/0000-0002-5712-5643
+ Nguyen, Amanda; ORCID: https://orcid.org/0000-0002-7359-1900
+ Hom, Doug; ORCID: https://orcid.org/0000-0003-4477-9135
+ Ferriere, Michael; ORCID: https://orcid.org/0000-0003-3112-9328
+ Li, Yifang; ORCID: https://orcid.org/0000-0002-7773-9546
+ Kompa, Jill; ORCID: https://orcid.org/0000-0002-2581-1294
+ Martic, Miljen; ORCID: https://orcid.org/0000-0002-0166-5421
+ Hinder, Markus; ORCID: https://orcid.org/0000-0003-2293-8342
+ Basson, Craig T; ORCID: https://orcid.org/0000-0003-0211-4936
+ Yowe, David; ORCID: https://orcid.org/0000-0003-3635-0662
+ Diener, John; ORCID: https://orcid.org/0000-0001-8163-8417
+ Goldfine, Allison B; ORCID: https://orcid.org/0000-0002-0345-1048
+Corporate Author
+ CLLF580X2102 Study Team
+Authors Full Name
+ Rader, Daniel J; Maratos-Flier, Eleftheria; Nguyen, Amanda; Hom, Doug; Ferriere, Michael; Li, Yifang; Kompa, Jill; Martic, Miljen; Hinder, Markus; Basson, Craig T; Yowe, David; Diener, John; Goldfine, Allison B.
+Institution
+ Rader, Daniel J. Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
+ Maratos-Flier, Eleftheria. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Nguyen, Amanda. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Hom, Doug. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Ferriere, Michael. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Li, Yifang. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Kompa, Jill. Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
+ Martic, Miljen. Novartis Pharma AG, Basel 4002, Switzerland.
+ Hinder, Markus. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Basson, Craig T. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Yowe, David. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Diener, John. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+ Goldfine, Allison B. Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Double-Blind Method
+ *Fatty Liver/pc [Prevention & Control]
+ Female
+ *Fibroblast Growth Factors/ad [Administration & Dosage]
+ Fibroblast Growth Factors/ge [Genetics]
+ Follow-Up Studies
+ Humans
+ Hypertriglyceridemia/ge [Genetics]
+ Hypertriglyceridemia/pa [Pathology]
+ *Hypertriglyceridemia/th [Therapy]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ *Triglycerides/bl [Blood]
+Keyword Heading
+ fibroblast growth factor 21 (FGF21)
+ hypertriglyceridemia
+ metabolism
+ nonalcoholic fatty liver diseases (NAFLD)
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: To evaluate the safety and potential efficacy of LLF580, a genetically engineered variant of human fibroblast growth factor-21, for triglyceride lowering, weight loss, and hepatic fat reduction.
+
+ METHODS: A multicenter, double-blind, parallel design trial in obese, mildly hypertriglyceridemic adults randomized (1:1) to LLF580 300 mg or placebo subcutaneously every 4 weeks for 3 doses.
+
+ RESULTS: Of 64 randomized study participants, 61 (mean +/- SD: age 45 +/- 11 years, 49% male, 80/15/5% Caucasian/African American/other, body mass index 36.1 +/- 3.8 kg/m2) received LLF580 (n = 30) or placebo (n = 31) at 7 research sites in the United States. LLF580 lowered serum triglycerides by 54% (least square mean placebo adjusted change from baseline), total cholesterol 7%, low-density lipoprotein cholesterol 12%, and increased high-density lipoprotein cholesterol 36% compared with placebo (all P < 0.001) over 12 weeks. Substantial reduction of liver fat of 52% over placebo (P < 0.001) was also demonstrated in the setting of improved liver function tests including alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase, the composite enhanced liver fibrosis score, and N-terminal type III collagen propeptide (all P < 0.05). Insulin and C-peptide levels and insulin resistance by homeostatic model assessment for insulin resistance were all lower, and adiponectin higher with LLF580 treatment compared with placebo, whereas fasting glucose and glycated hemoglobin were unchanged. Reductions in biomarkers of bone formation without differences in markers of bone resorption were observed. LLF580 was generally safe and well tolerated, except for higher incidence of generally mild to moderate gastrointestinal adverse effects.
+
+ CONCLUSIONS: In obese, mildly hypertriglyceridemic adults, LLF580 was generally safe and demonstrated beneficial effects on serum lipids, liver fat, and biomarkers of liver injury, suggesting it may be effective for treatment of select metabolic disorders including hypertriglyceridemia and nonalcoholic fatty liver disease. Assessments of longer term safety and efficacy are warranted.
+
+ CLINICALTRIALS.GOV IDENTIFIER: NCT03466203. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1210%2fclinem%2fdgab624
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rader&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=LLF580%2C+an+FGF21+Analog%2C+Reduces+Triglycerides+and+Hepatic+Fat+in+Obese+Adults+With+Modest+Hypertriglyceridemia.&volume=107&issue=1&spage=e57&epage=e70&date=2022&doi=10.1210%2Fclinem%2Fdgab624&pmid=34431493&sid=OVID:medline
+
+<630>
+Unique Identifier
+ 34415992
+Title
+ Network Analyses Reveal Negative Link Between Changes in Adipose Tissue GDF15 and BMI During Dietary-induced Weight Loss.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 107(1):e130-e142, 2022 01 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Imbert A; Vialaneix N; Marquis J; Vion J; Charpagne A; Metairon S; Laurens C; Moro C; Boulet N; Walter O; Lefebvre G; Hager J; Langin D; Saris WHM; Astrup A; Viguerie N; Valsesia A
+Author NameID
+ Imbert, Alyssa; ORCID: https://orcid.org/0000-0003-4868-8927
+ Vialaneix, Nathalie; ORCID: https://orcid.org/0000-0003-1156-0639
+ Marquis, Julien; ORCID: https://orcid.org/0000-0002-2020-1534
+ Vion, Julie; ORCID: https://orcid.org/0000-0002-2028-3680
+ Laurens, Claire; ORCID: https://orcid.org/0000-0001-5014-8319
+ Moro, Cedric; ORCID: https://orcid.org/0000-0003-4294-0597
+ Boulet, Nathalie; ORCID: https://orcid.org/0000-0003-1011-3474
+ Walter, Ondine; ORCID: https://orcid.org/0000-0003-0869-7917
+ Hager, Jorg; ORCID: https://orcid.org/0000-0002-6634-9294
+ Langin, Dominique; ORCID: https://orcid.org/0000-0002-2669-7825
+ Saris, Wim H M; ORCID: https://orcid.org/0000-0003-0985-0047
+ Astrup, Arne; ORCID: https://orcid.org/0000-0001-8968-8996
+ Viguerie, Nathalie; ORCID: https://orcid.org/0000-0002-1730-9915
+ Valsesia, Armand; ORCID: https://orcid.org/0000-0003-0746-9664
+Authors Full Name
+ Imbert, Alyssa; Vialaneix, Nathalie; Marquis, Julien; Vion, Julie; Charpagne, Aline; Metairon, Sylviane; Laurens, Claire; Moro, Cedric; Boulet, Nathalie; Walter, Ondine; Lefebvre, Gregory; Hager, Jorg; Langin, Dominique; Saris, Wim H M; Astrup, Arne; Viguerie, Nathalie; Valsesia, Armand.
+Institution
+ Imbert, Alyssa. Institut National de la Sante et de la Recherche Medicale (Inserm), UMR1297, Institute of Metabolic and Cardiovascular Diseases, Team Metabolic Disorders and Diabesity, 31400, Toulouse, France.
+ Imbert, Alyssa. Universite de Toulouse, UMR1297, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 31400, Toulouse, France.
+ Imbert, Alyssa. INRAE, UR875 Mathematiques et Informatique Appliquees Toulouse, F-31326 Castanet-Tolosan, France.
+ Vialaneix, Nathalie. INRAE, UR875 Mathematiques et Informatique Appliquees Toulouse, F-31326 Castanet-Tolosan, France.
+ Marquis, Julien. Universite de Lausanne, Genomic Technologies Facility, 1015, Lausanne, Switzerland.
+ Vion, Julie. Institut National de la Sante et de la Recherche Medicale (Inserm), UMR1297, Institute of Metabolic and Cardiovascular Diseases, Team Metabolic Disorders and Diabesity, 31400, Toulouse, France.
+ Vion, Julie. Universite de Toulouse, UMR1297, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 31400, Toulouse, France.
+ Charpagne, Aline. Nestle Institute of Health Sciences, Metabolic Health Department, 1015, Lausanne, Switzerland.
+ Metairon, Sylviane. Nestle Institute of Health Sciences, Metabolic Health Department, 1015, Lausanne, Switzerland.
+ Laurens, Claire. Institut National de la Sante et de la Recherche Medicale (Inserm), UMR1297, Institute of Metabolic and Cardiovascular Diseases, Team Metabolic Disorders and Diabesity, 31400, Toulouse, France.
+ Laurens, Claire. Universite de Toulouse, UMR1297, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 31400, Toulouse, France.
+ Moro, Cedric. Institut National de la Sante et de la Recherche Medicale (Inserm), UMR1297, Institute of Metabolic and Cardiovascular Diseases, Team Metabolic Disorders and Diabesity, 31400, Toulouse, France.
+ Moro, Cedric. Universite de Toulouse, UMR1297, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 31400, Toulouse, France.
+ Boulet, Nathalie. Institut National de la Sante et de la Recherche Medicale (Inserm), UMR1297, Institute of Metabolic and Cardiovascular Diseases, Team Metabolic Disorders and Diabesity, 31400, Toulouse, France.
+ Boulet, Nathalie. Institut National de la Sante et de la Recherche Medicale (Inserm), UMR1297, Institute of Metabolic and Cardiovascular Diseases, Team Adipose tissue, microbiota and cardiometabolic flexibility, 31400, Toulouse, France.
+ Walter, Ondine. Nestle Institute of Health Sciences, Metabolic Health Department, 1015, Lausanne, Switzerland.
+ Lefebvre, Gregory. Nestle Institute of Health Sciences, Metabolic Health Department, 1015, Lausanne, Switzerland.
+ Hager, Jorg. Nestle Institute of Health Sciences, Metabolic Health Department, 1015, Lausanne, Switzerland.
+ Langin, Dominique. Institut National de la Sante et de la Recherche Medicale (Inserm), UMR1297, Institute of Metabolic and Cardiovascular Diseases, Team Metabolic Disorders and Diabesity, 31400, Toulouse, France.
+ Langin, Dominique. Universite de Toulouse, UMR1297, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 31400, Toulouse, France.
+ Langin, Dominique. Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague and Paul Sabatier University, Toulouse, France.
+ Langin, Dominique. Toulouse University Hospitals, Laboratory of Clinical Biochemistry, 31000, Toulouse, France.
+ Saris, Wim H M. Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
+ Astrup, Arne. Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen, Denmark.
+ Viguerie, Nathalie. Institut National de la Sante et de la Recherche Medicale (Inserm), UMR1297, Institute of Metabolic and Cardiovascular Diseases, Team Metabolic Disorders and Diabesity, 31400, Toulouse, France.
+ Viguerie, Nathalie. Universite de Toulouse, UMR1297, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 31400, Toulouse, France.
+ Viguerie, Nathalie. Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague and Paul Sabatier University, Toulouse, France.
+ Valsesia, Armand. Nestle Institute of Health Sciences, Metabolic Health Department, 1015, Lausanne, Switzerland.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pa [Pathology]
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ *Diet, Reducing
+ Female
+ Follow-Up Studies
+ *Gene Regulatory Networks
+ Growth Differentiation Factor 15/ge [Genetics]
+ *Growth Differentiation Factor 15/me [Metabolism]
+ Humans
+ Male
+ Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Prognosis
+ *Transcriptome
+ *Weight Loss
+Keyword Heading
+ Adipocyte
+ inflammation
+ low calorie diet
+ macrophage
+ network analyses
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Adipose tissue (AT) transcriptome studies provide holistic pictures of adaptation to weight and related bioclinical settings changes.
+
+ OBJECTIVE: To implement AT gene expression profiling and investigate the link between changes in bioclinical parameters and AT gene expression during 3 steps of a 2-phase dietary intervention (DI).
+
+ METHODS: AT transcriptome profiling was obtained from sequencing 1051 samples, corresponding to 556 distinct individuals enrolled in a weight loss intervention (8-week low-calorie diet (LCD) at 800 kcal/day) followed with a 6-month ad libitum randomized DI. Transcriptome profiles obtained with QuantSeq sequencing were benchmarked against Illumina RNAseq. Reverse transcription quantitative polymerase chain reaction was used to further confirm associations. Cell specificity was assessed using freshly isolated cells and THP-1 cell line.
+
+ RESULTS: During LCD, 5 modules were found, of which 3 included at least 1 bioclinical variable. Change in body mass index (BMI) connected with changes in mRNA level of genes with inflammatory response signature. In this module, change in BMI was negatively associated with changes in expression of genes encoding secreted protein (GDF15, CCL3, and SPP1). Through all phases of the DI, change in GDF15 was connected to changes in SPP1, CCL3, LIPA and CD68. Further characterization showed that these genes were specific to macrophages (with LIPA, CD68 and GDF15 expressed in anti-inflammatory macrophages) and GDF15 also expressed in preadipocytes.
+
+ CONCLUSION: Network analyses identified a novel AT feature with GDF15 upregulated with calorie restriction induced weight loss, concomitantly to macrophage markers. In AT, GDF15 was expressed in preadipocytes and macrophages where it was a hallmark of anti-inflammatory cells. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (GDF15 protein, human). 0 (Growth Differentiation Factor 15).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1210%2fclinem%2fdgab621
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Imbert&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Network+Analyses+Reveal+Negative+Link+Between+Changes+in+Adipose+Tissue+GDF15+and+BMI+During+Dietary-induced+Weight+Loss.&volume=107&issue=1&spage=e130&epage=e142&date=2022&doi=10.1210%2Fclinem%2Fdgab621&pmid=34415992&sid=OVID:medline
+
+<631>
+Unique Identifier
+ 34388702
+Title
+ Sex-Specific Associations Between Bone-Loading Score and Adiposity Markers in Middle-Aged and Older Adults.
+Source
+ Journal of Aging & Physical Activity. 30(1):82-88, 2022 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Singh H; Moore BA; Rathore R; Bemben MG; Bemben DA
+Authors Full Name
+ Singh, Harshvardhan; Moore, Bethany A; Rathore, Roshita; Bemben, Michael G; Bemben, Debra A.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Adiposity/ph [Physiology]
+ *Adiposity
+ Aged
+ Biomarkers
+ Body Composition/ph [Physiology]
+ Body Mass Index
+ Female
+ Humans
+ Male
+ Middle Aged
+ Muscle, Skeletal
+ *Obesity
+Keyword Heading
+ balance
+ body composition
+ fat
+ mechanical loading
+ postural stability
+ women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The authors examined sex-specific relationships between fat mass index (FMI), android/gynoid (A/G) fat ratio, relative skeletal muscle mass index, and Bone-Specific Physical Activity Questionnaire derived bone-loading scores (BLSs) in middle-aged and older adults (men, n = 27; women, n = 33; age = 55-75 years). The FMI, A/G fat ratio, and relative skeletal muscle mass index were estimated by dual-energy X-ray absorptiometry. The Bone-Specific Physical Activity Questionnaire was used to assess: (a) BLSpast (age 1 until 12 months before the study visit), (b) BLScurrent (last 12 months), and (c) BLStotal (average of [a] and [b]) scores. Separate multiple linear regression analysis of (a) age, FMI, and relative skeletal muscle mass index and (b) age, height, and A/G fat ratio versus BLS revealed that FMI and A/G fat ratio were negatively associated with BLSpast and BLStotal (p < .05) in women only. Adiposity and, specifically, central adiposity is negatively related to bone-loading physical activity in middle-aged and older women.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1123%2fjapa.2020-0200
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Singh&issn=1063-8652&title=Journal+of+Aging+%26+Physical+Activity&atitle=Sex-Specific+Associations+Between+Bone-Loading+Score+and+Adiposity+Markers+in+Middle-Aged+and+Older+Adults.&volume=30&issue=1&spage=82&epage=88&date=2022&doi=10.1123%2Fjapa.2020-0200&pmid=34388702&sid=OVID:medline
+
+<632>
+Unique Identifier
+ 34369225
+Title
+ Association of Sugar Intake with Inflammation- and Angiogenesis-Related Biomarkers in Newly Diagnosed Colorectal Cancer Patients.
+Source
+ Nutrition & Cancer. 74(5):1636-1643, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stewart KL; Gigic B; Himbert C; Warby CA; Ose J; Lin T; Schrotz-King P; Boehm J; Jordan KC; Metos J; Schneider M; Figueiredo JC; Li CI; Shibata D; Siegel E; Toriola AT; Hardikar S; Ulrich CM
+Author NameID
+ Jordan, Kristine C; ORCID: https://orcid.org/0000-0002-0688-6514
+ Metos, Julie; ORCID: https://orcid.org/0000-0003-4531-7725
+Authors Full Name
+ Stewart, Kelly L; Gigic, Biljana; Himbert, Caroline; Warby, Christy A; Ose, Jennifer; Lin, Tengda; Schrotz-King, Petra; Boehm, Jurgen; Jordan, Kristine C; Metos, Julie; Schneider, Martin; Figueiredo, Jane C; Li, Christopher I; Shibata, David; Siegel, Erin; Toriola, Adetunji T; Hardikar, Sheetal; Ulrich, Cornelia M.
+Institution
+ Stewart, Kelly L. Department of Nutrition and Integrated Physiology, University of Utah, Salt Lake City, United States.
+ Gigic, Biljana. Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
+ Himbert, Caroline. Huntsman Cancer Institute, Population Sciences, Salt Lake City, Utah.
+ Himbert, Caroline. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Warby, Christy A. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Ose, Jennifer. Huntsman Cancer Institute, Population Sciences, Salt Lake City, Utah.
+ Ose, Jennifer. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Lin, Tengda. Huntsman Cancer Institute, Population Sciences, Salt Lake City, Utah.
+ Lin, Tengda. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Schrotz-King, Petra. Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
+ Boehm, Jurgen. Huntsman Cancer Institute, Population Sciences, Salt Lake City, Utah.
+ Boehm, Jurgen. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Jordan, Kristine C. Department of Nutrition and Integrated Physiology, University of Utah, Salt Lake City, United States.
+ Metos, Julie. Department of Nutrition and Integrated Physiology, University of Utah, Salt Lake City, United States.
+ Schneider, Martin. Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
+ Figueiredo, Jane C. Cedars-Sinai Medical Center, Los Angeles, California, USA.
+ Li, Christopher I. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
+ Shibata, David. The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
+ Siegel, Erin. H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
+ Toriola, Adetunji T. School of Medicine, Washington University, St. Louis, Missouri, USA.
+ Hardikar, Sheetal. Huntsman Cancer Institute, Population Sciences, Salt Lake City, Utah.
+ Hardikar, Sheetal. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Hardikar, Sheetal. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
+ Ulrich, Cornelia M. Huntsman Cancer Institute, Population Sciences, Salt Lake City, Utah.
+ Ulrich, Cornelia M. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+MeSH Subject Headings
+ Biomarkers
+ *Colorectal Neoplasms
+ Female
+ Fructose/ae [Adverse Effects]
+ Glucose
+ Humans
+ *Inflammation
+ Male
+ Middle Aged
+ Neovascularization, Pathologic
+ Obesity
+ Sucrose
+Abstract
+ Evidence suggests a positive association between sugar intake and colorectal cancer (CRC) outcomes. We sought to investigate inflammation and angiogenesis as underlying mechanisms behind increased sugar intake and worse CRC outcomes. Pre-surgery serum samples were obtained from 191 patients diagnosed with primary invasive stage I-IV CRC. Biomarkers of inflammation (CRP, SAA, IL-6, IL-8, MCP-1, TNFalpha) and angiogenesis (VEGFA, VEGFD, sICAM-1 and sVCAM-1) were analyzed (Meso-Scale-Discovery). Fructose, glucose, sucrose, and total sugar intake (calories/day, % total calories) were assessed by FFQ. Pearson's correlation and multiple linear regression analyses were performed. Patients were on average 64 years old, 64% were male, the majority was diagnosed with stage II-III (58%) cancers, and 67% were either overweight or obese. Among normal-weight individuals (BMI <25 kg/m2), we observed a significant inverse association between VEGFD and any type of sugar intake in cal/day (sucrose: p = 0.01, glucose and fructose: p < 0.001) and MCP-1 and fructose intake (p = 0.05). The magnitude of reduction in VEGF ranged between -1.24 for sucrose to 4.49 for glucose intake, and -2.64 for fructose intake for MCP-1 levels. Sugar intake was associated with some inflammation or angiogenesis biomarkers, among CRC patients; differences were observed by adiposity that warrant further investigation.Supplemental data for this article is available online at at 10.1080/01635581.2021.1957133.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 30237-26-4 (Fructose). 57-50-1 (Sucrose). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f01635581.2021.1957133
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stewart&issn=0163-5581&title=Nutrition+%26+Cancer&atitle=Association+of+Sugar+Intake+with+Inflammation-+and+Angiogenesis-Related+Biomarkers+in+Newly+Diagnosed+Colorectal+Cancer+Patients.&volume=74&issue=5&spage=1636&epage=1643&date=2022&doi=10.1080%2F01635581.2021.1957133&pmid=34369225&sid=OVID:medline
+
+<633>
+Unique Identifier
+ 34085881
+Title
+ The Effects of Synbiotic Supplementation on Serum Anti-Inflammatory Factors in the Survivors of Breast Cancer with Lymphedema following a Low Calorie Diet: A Randomized, Double-Blind, Clinical Trial.
+Source
+ Nutrition & Cancer. 74(3):869-881, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Saneei Totmaj A; Haghighat S; Jaberzadeh S; Navaei M; Vafa S; Janani L; Emamat H; Salehi Z; Izad M; Zarrati M
+Author NameID
+ Emamat, Hadi; ORCID: https://orcid.org/0000-0002-8562-9136
+ Zarrati, Mitra; ORCID: https://orcid.org/0000-0002-2123-3319
+Authors Full Name
+ Saneei Totmaj, Ali; Haghighat, Shahpar; Jaberzadeh, Shapour; Navaei, Mehraban; Vafa, Saeideh; Janani, Leila; Emamat, Hadi; Salehi, Zahra; Izad, Maryam; Zarrati, Mitra.
+Institution
+ Saneei Totmaj, Ali. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Haghighat, Shahpar. Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
+ Jaberzadeh, Shapour. Department of Physiotherapy, School of Primary and Allied Health Care, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Australia.
+ Navaei, Mehraban. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Vafa, Saeideh. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Janani, Leila. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Emamat, Hadi. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Salehi, Zahra. Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
+ Izad, Maryam. Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
+ Zarrati, Mitra. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+MeSH Subject Headings
+ Adiponectin
+ Anti-Inflammatory Agents
+ Biomarkers
+ Breast Neoplasms/co [Complications]
+ Breast Neoplasms/dt [Drug Therapy]
+ *Breast Neoplasms
+ Caloric Restriction
+ *Cancer Survivors
+ Double-Blind Method
+ Edema/co [Complications]
+ Female
+ Humans
+ Interleukin-10
+ Lymphedema/et [Etiology]
+ Lymphedema/th [Therapy]
+ *Lymphedema
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+ *Synbiotics
+ Transforming Growth Factor beta
+ Vascular Endothelial Growth Factor A
+Abstract
+ BACKGROUND AND AIM: Breast cancer-related lymphedema (BCRL) is a treatment-related inflammatory complication in breast cancer survivors (BCSs). This study was aimed to evaluate the effect of synbiotic supplementation on serum concentrations of IL-10, TGF-beta, VEGF, adiponectin, and edema volume among overweight or obese BCSs with lymphedema following a low-calorie diet (LCD).
+
+ METHOD: In a randomized double-blind, controlled clinical trial, 88 obese and overweight BCSs women were randomized to synbiotic supplement (n = 44) or placebo (n = 44) groups and both groups followed an LCD for 10 weeks. Pre- and post-intervention comparisons were made regarding the anti-inflammatory markers which included IL-10, TGF-beta, VEGF, adiponectin, edema volume, and anthropometric measurements. Also, the same factors were analyzed to find inter-group disparities.
+
+ RESULTS: There were no significant differences among participants in the baseline, except for IL-10 and adiponectin. Post-intervention, no significant differences were observed regarding the anti-inflammatory markers, including IL-10, VEGF, adiponectin, and TGF-beta between the groups. After 10 weeks of intervention edema volume significantly decreased in the synbiotic group; additionally, anthropometric measurements (body weight, BMI, body fat percent, and WC) decreased in both groups significantly (P < 0.001 and P < 0.005; respectively).
+
+ CONCLUSION: Synbiotic supplementation coupled with an LCD in a 10-week intervention had beneficial effects on increasing the serum TGF-beta, IL-10, and adiponectin levels in women with BCRL. It also reduced arm lymphedema volume. Therefore, synbiotic supplementation can be effective in improving health status in BCRL patients.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Anti-Inflammatory Agents). 0 (Biomarkers). 0 (Transforming Growth Factor beta). 0 (Vascular Endothelial Growth Factor A). 130068-27-8 (Interleukin-10).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f01635581.2021.1933096
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Saneei+Totmaj&issn=0163-5581&title=Nutrition+%26+Cancer&atitle=The+Effects+of+Synbiotic+Supplementation+on+Serum+Anti-Inflammatory+Factors+in+the+Survivors+of+Breast+Cancer+with+Lymphedema+following+a+Low+Calorie+Diet%3A+A+Randomized%2C+Double-Blind%2C+Clinical+Trial.&volume=74&issue=3&spage=869&epage=881&date=2022&doi=10.1080%2F01635581.2021.1933096&pmid=34085881&sid=OVID:medline
+
+<634>
+Unique Identifier
+ 33909529
+Title
+ The effects of tocotrienols intake on obesity, blood pressure, inflammation, liver and glucose biomarkers: a meta-analysis of randomized controlled trials.
+Source
+ Critical Reviews in Food Science & Nutrition. 62(26):7154-7167, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li F; Xu B; Soltanieh S; Zanghelini F; Abu-Zaid A; Sun J
+Author NameID
+ Abu-Zaid, Ahmed; ORCID: https://orcid.org/0000-0003-2286-2181
+ Sun, Jian; ORCID: https://orcid.org/0000-0002-0977-9474
+Authors Full Name
+ Li, Fengxiang; Xu, Biao; Soltanieh, Samira; Zanghelini, Fernando; Abu-Zaid, Ahmed; Sun, Jian.
+Institution
+ Li, Fengxiang. Second Department of Cardiology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China.
+ Xu, Biao. Second Department of Cardiology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China.
+ Soltanieh, Samira. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Zanghelini, Fernando. Postgraduate Program in Therapeutic Innovation, Federal University of Pernambuco, Pernambuco, Brazil.
+ Abu-Zaid, Ahmed. Department of Pharmacology, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
+ Sun, Jian. School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, China.
+MeSH Subject Headings
+ Biomarkers
+ Blood Pressure
+ Dietary Supplements
+ Glucose
+ Humans
+ *Hypertension
+ Inflammation
+ Liver
+ Obesity/dt [Drug Therapy]
+ Randomized Controlled Trials as Topic
+ Tocotrienols/pd [Pharmacology]
+ *Tocotrienols
+Keyword Heading
+ BMI
+ Blood Pressure
+ Inflammation
+ Liver
+ Tocotrienol
+ Vegetable oils
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The objective of this study is to accomplish a systematic review and meta-analysis of all randomized controlled trials that dissected the influence of tocotrienol supplementation on various anthropometric and cardiometabolic indices in all individuals, irrespective of health condition. This research was carried out in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement guidelines. 17 eligible articles were included in the final quantitative analysis. Current study revealed that tocotrienol consumption was not associated with CRP, WC, MDA, BMI, IL-6, HbA1C, ALT, AST, creatinine TNF-alpha, FPG, BW, DBP, and SBP. We did observe an overall increase in BW (SMD: 0.063 kg, 95% CI: -0.200, 0.327, p = 0.637) and DBP (SMD: 0.249 mmHg, 95% CI: 0.053, 0.446, p = 0.013). In addition, a significant reduction in SBP was observed (SMD: -0.616 mmHg, 95% CI: -1.123, -0.110, p = 0.017). In summary, our meta-analysis revealed that tocotrienol consumption was associated with increase in BW and DBP and decrease in SBP. Significant associations were not observed for other outcomes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Tocotrienols). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f10408398.2021.1911926
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1040-8398&title=Critical+Reviews+in+Food+Science+%26+Nutrition&atitle=The+effects+of+tocotrienols+intake+on+obesity%2C+blood+pressure%2C+inflammation%2C+liver+and+glucose+biomarkers%3A+a+meta-analysis+of+randomized+controlled+trials.&volume=62&issue=26&spage=7154&epage=7167&date=2022&doi=10.1080%2F10408398.2021.1911926&pmid=33909529&sid=OVID:medline
+
+<635>
+Unique Identifier
+ 33905269
+Title
+ The effect of brown rice compared to white rice on adiposity indices, lipid profile, and glycemic markers: a systematic review and meta-analysis of randomized controlled trials.
+Source
+ Critical Reviews in Food Science & Nutrition. 62(27):7395-7412, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Golzarand M; Toolabi K; Eskandari Delfan S; Mirmiran P
+Author NameID
+ Golzarand, Mahdieh; ORCID: https://orcid.org/0000-0003-2651-9276
+Authors Full Name
+ Golzarand, Mahdieh; Toolabi, Karamollah; Eskandari Delfan, Sina; Mirmiran, Parvin.
+Institution
+ Golzarand, Mahdieh. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Toolabi, Karamollah. Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
+ Eskandari Delfan, Sina. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
+ Mirmiran, Parvin. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Mirmiran, Parvin. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose
+ Cholesterol
+ Humans
+ Lipoproteins, LDL/me [Metabolism]
+ Obesity
+ *Oryza
+ Randomized Controlled Trials as Topic
+ Triglycerides
+Keyword Heading
+ Brown rice
+ glycemia
+ lipid profile
+ meta-analysis
+ obesity
+ white rice
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ A few randomized controlled trials (RCTs) have assessed the effect of brown rice consumption on metabolic parameters compared to white rice, with inconsistent findings. Therefore, the present systematic review and meta-analysis was designed to evaluate the effect of brown rice on adiposity indices, lipid profile, and glycemic markers in adult subjects compared to white rice. In this study, PubMed/Medline, Scopus, Web of Sciences, and Embase databases were comprehensively searched until March 2021. Thirteen RCTs were selected and then included in the meta-analysis. As reported, brown rice significantly reduced weight by -1.63 kg (95% CI: -2.15 to -1.11, I2=97%, n = 6), body mass index (BMI) by -0.58 kg/m2 (95% CI: -0.78 to -0.37, I2=96%, n = 6), and waist circumference by -2.56 cm (95% CI: -4.86 to -0.26, I2=88%, n = 5) compared with white rice. Moreover, it had no significant effect on lipid profile and glycemic markers. Besides, pre-germinated brown rice significantly declined weight (-1.75 kg, 95% CI: -2.70 to -0.81, I2=99%, n = 4), total cholesterol (-24.22 mg/dl, 95% CI: -33.03 to -15.41, I2=78%, n = 5), triglyceride (TG) (-43.28 mg/dl, 95% CI: -74.05 to -12.50, I2=90%, n = 5), low-density lipoprotein (LDL) (-20.05 mg/dl, 95% CI: -29.57 to -10.52, I2=71%, n = 5), and fasting blood glucose (FBG) (-15.83 mg/dl, 95% CI: -25.20 to -6.46, I2=91%, n = 5). In accordance with Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, the certainly of the included evidence was low and very low. The results of the present study indicate that, brown rice has anti-obesity effects in comparison with white rice; however, it has no beneficial effects on lipid profile and glycemic markers. Contrary to brown rice, it was shown that, pre-germinated brown rice significantly decreases body weight and improves lipid profile and FBG levels compared to white rice. Accordingly, our results indicate that, pre-germinated brown rice has better functional effects on promoting lipid profile and FBG compared to brown rice.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipoproteins, LDL). 0 (Triglycerides). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f10408398.2021.1914541
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Golzarand&issn=1040-8398&title=Critical+Reviews+in+Food+Science+%26+Nutrition&atitle=The+effect+of+brown+rice+compared+to+white+rice+on+adiposity+indices%2C+lipid+profile%2C+and+glycemic+markers%3A+a+systematic+review+and+meta-analysis+of+randomized+controlled+trials.&volume=62&issue=27&spage=7395&epage=7412&date=2022&doi=10.1080%2F10408398.2021.1914541&pmid=33905269&sid=OVID:medline
+
+<636>
+Unique Identifier
+ 33693634
+Title
+ Abdominal and gluteo-femoral markers of adiposity and risk of vascular-metabolic mortality in a prospective study of 150 000 Mexican adults.
+Source
+ European Journal of Preventive Cardiology. 29(5):730-738, 2022 05 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gnatiuc L; Tapia-Conyer R; Wade R; Ramirez-Reyes R; Aguilar-Ramirez D; Herrington W; Hill M; Lewington S; Torres J; Trichia E; Collins R; Peto R; Clarke R; Kuri-Morales P; Emberson JR; Alegre-Diaz J
+Author NameID
+ Gnatiuc, Louisa; ORCID: https://orcid.org/0000-0002-0641-2220
+ Tapia-Conyer, Roberto; ORCID: https://orcid.org/0000-0003-3814-2904
+ Wade, Rachel; ORCID: https://orcid.org/0000-0001-9826-6322
+ Ramirez-Reyes, Raul; ORCID: https://orcid.org/0000-0001-9763-324X
+ Aguilar-Ramirez, Diego; ORCID: https://orcid.org/0000-0003-2298-3768
+ Herrington, William; ORCID: https://orcid.org/0000-0003-1172-8243
+ Hill, Michael; ORCID: https://orcid.org/0000-0002-3861-6105
+ Lewington, Sarah; ORCID: https://orcid.org/0000-0002-4496-4771
+ Torres, Jason; ORCID: https://orcid.org/0000-0002-7537-7035
+ Trichia, Eirini; ORCID: https://orcid.org/0000-0002-7655-5905
+ Collins, Rory; ORCID: https://orcid.org/0000-0001-8288-8602
+ Peto, Richard; ORCID: https://orcid.org/0000-0001-8219-5339
+ Clarke, Robert; ORCID: https://orcid.org/0000-0002-9802-8241
+ Kuri-Morales, Pablo; ORCID: https://orcid.org/0000-0002-0704-9507
+ Emberson, Jonathan R; ORCID: https://orcid.org/0000-0001-7792-9422
+ Alegre-Diaz, Jesus; ORCID: https://orcid.org/0000-0001-9390-3871
+Authors Full Name
+ Gnatiuc, Louisa; Tapia-Conyer, Roberto; Wade, Rachel; Ramirez-Reyes, Raul; Aguilar-Ramirez, Diego; Herrington, William; Hill, Michael; Lewington, Sarah; Torres, Jason; Trichia, Eirini; Collins, Rory; Peto, Richard; Clarke, Robert; Kuri-Morales, Pablo; Emberson, Jonathan R; Alegre-Diaz, Jesus.
+Institution
+ Gnatiuc, Louisa. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Tapia-Conyer, Roberto. School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
+ Wade, Rachel. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Wade, Rachel. MRC Population Health Research Unit, NDPH, University of Oxford, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK.
+ Ramirez-Reyes, Raul. School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
+ Aguilar-Ramirez, Diego. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Herrington, William. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Herrington, William. MRC Population Health Research Unit, NDPH, University of Oxford, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK.
+ Hill, Michael. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Hill, Michael. MRC Population Health Research Unit, NDPH, University of Oxford, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK.
+ Lewington, Sarah. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Lewington, Sarah. MRC Population Health Research Unit, NDPH, University of Oxford, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK.
+ Lewington, Sarah. UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
+ Torres, Jason. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Trichia, Eirini. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Collins, Rory. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Peto, Richard. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Clarke, Robert. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Kuri-Morales, Pablo. School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
+ Emberson, Jonathan R. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK.
+ Emberson, Jonathan R. MRC Population Health Research Unit, NDPH, University of Oxford, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK.
+ Alegre-Diaz, Jesus. School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers
+ Body Mass Index
+ Female
+ Humans
+ Male
+ Mexico/ep [Epidemiology]
+ Obesity/co [Complications]
+ Obesity, Abdominal/co [Complications]
+ Obesity, Abdominal/di [Diagnosis]
+ *Obesity, Abdominal
+ Prospective Studies
+ Risk Factors
+ Waist Circumference
+ Waist-Hip Ratio
+Keyword Heading
+ Abdominal adiposity
+ Cause-specific mortality
+ Gluteo-femoral adiposity
+ Mexico
+ Prospective cohort study
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Results of previous studies of abdominal adiposity and risk of vascular-metabolic mortality in Hispanic populations have been conflicting. We report results from a large prospective study of Mexican adults with high levels of abdominal adiposity.
+
+ METHODS AND RESULTS: A total of 159 755 adults aged >=35 years from Mexico City were enrolled in a prospective study and followed for 16 years. Cox regression, adjusted for confounders, yielded mortality rate ratios (RRs) associated with three markers of abdominal adiposity (waist circumference, waist-hip ratio, and waist-height ratio) and one marker of gluteo-femoral adiposity (hip circumference) for cause-specific mortality before age 75 years. To reduce reverse causality, deaths in the first 5 years of follow-up and participants with diabetes or other prior chronic disease were excluded. Among 113 163 participants without prior disease and aged 35-74 years at recruitment, all adiposity markers were positively associated with vascular-metabolic mortality. Comparing the top versus bottom tenth of the sex-specific distributions, the vascular-metabolic mortality RRs at ages 40-74 years were 2.32 [95% confidence interval (CI) 1.84-2.94] for waist circumference, 2.22 (1.71-2.88) for the waist-hip ratio, 2.63 (2.06-3.36) for the waist-height ratio, and 1.58 (1.29-1.93) for hip circumference. The RRs corresponding to each standard deviation (SD) higher usual levels of these adiposity markers were 1.34 (95% CI 1.27-1.41), 1.31 (1.23-1.39), 1.38 (1.31-1.45), and 1.18 (1.13-1.24), respectively. For the markers of abdominal adiposity, the RRs did not change much after further adjustment for other adiposity markers, but for hip circumference the association was reversed; given body mass index and waist circumference, the RR for vascular-metabolic mortality for each one SD higher usual hip circumference was 0.80 (0.75-0.86).
+
+ CONCLUSIONS: In this study of Mexican adults, abdominal adiposity (and in particular the waist-height ratio) was strongly and positively associated with vascular-metabolic mortality. For a given amount of general and abdominal adiposity, however, higher hip circumference was associated with lower vascular-metabolic mortality. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1093%2feurjpc%2fzwab038
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gnatiuc&issn=2047-4873&title=European+Journal+of+Preventive+Cardiology&atitle=Abdominal+and+gluteo-femoral+markers+of+adiposity+and+risk+of+vascular-metabolic+mortality+in+a+prospective+study+of+150+000+Mexican+adults.&volume=29&issue=5&spage=730&epage=738&date=2022&doi=10.1093%2Feurjpc%2Fzwab038&pmid=33693634&sid=OVID:medline
+
+<637>
+Unique Identifier
+ 33618372
+Title
+ Impact of Smoking, Obesity and Maternal Diabetes on SHBG Levels in Newborns.
+Source
+ Experimental & Clinical Endocrinology & Diabetes. 130(5):335-342, 2022 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aydin BK; Yasa B; Moore JP; Yasa C; Poyrazoglu S; Bas F; Coban A; Darendeliler F; Winters SJ
+Authors Full Name
+ Aydin, Banu Kucukemre; Yasa, Beril; Moore, Joseph P; Yasa, Cenk; Poyrazoglu, Sukran; Bas, Firdevs; Coban, Asuman; Darendeliler, Feyza; Winters, Stephen J.
+Institution
+ Aydin, Banu Kucukemre. Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey.
+ Yasa, Beril. Division of Neonatology, Istanbul University, Istanbul, Turkey.
+ Moore, Joseph P. Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky, USA.
+ Yasa, Cenk. Department of Obstetrics, Gynecology and Women's Health, Istanbul University, Istanbul, Turkey.
+ Poyrazoglu, Sukran. Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey.
+ Bas, Firdevs. Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey.
+ Coban, Asuman. Division of Neonatology, Istanbul University, Istanbul, Turkey.
+ Darendeliler, Feyza. Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey.
+ Winters, Stephen J. Division of Endocrinology, Metabolism and Diabetes. University of Louisville, Louisville, Kentucky, USA.
+MeSH Subject Headings
+ Biomarkers
+ Birth Weight
+ Cross-Sectional Studies
+ *Diabetes, Gestational
+ Female
+ Humans
+ Infant, Newborn
+ Longitudinal Studies
+ Obesity
+ Pregnancy
+ Smoking/ae [Adverse Effects]
+Abstract
+ BACKGROUND: Low levels of SHBG have become a marker for insulin resistance and diabetes. Babies born to mothers who are obese, have diabetes, or smoke during pregnancy are at greater risk of developing obesity and diabetes later in life.
+
+ AIMS: To examine the impact of maternal obesity, diabetes and smoking on SHBG levels in newborns.
+
+ STUDY DESIGN: This cross-sectional study is part of an ongoing multicenter, longitudinal study.
+
+ SUBJECTS: 98 healthy newborns and their parents, including 16 mothers with diabetes and 31 mothers with a smoking history.
+
+ OUTCOME MEASURES: Cord blood and second day venipuncture samples were collected for measurement of SHBG and insulin.
+
+ RESULTS: Babies born to mothers with diabetes had lower SHBG levels in cord blood [14.0 (8.9-20.4) vs. 19.6 (14.9-25.1) nmol/L; p=0.011] and on day 2 [18.8 (12.6-21.2) vs. 22.9 (17.1-29.1) nmol/L; p=0.015] than controls. Maternal diabetes remained negatively associated with SHBG levels in cord blood (p=0.02) and on day 2 (p=0.04) when adjusted for mothers' age, smoking status, pre-pregnancy weight and weight gain during pregnancy. SHBG levels in cord blood and day 2 samples were similar in babies born to mothers who were overweight-obese but not diabetic vs. normal weight, or were smokers when compared to non-smokers.
+
+ CONCLUSIONS: SHBG levels are lower in newborns born to mothers with diabetes than without diabetes, and may be a marker for babies' life-long risk for abnormal metabolic health. On the other hand, the adverse effects of tobacco smoke on the fetus do not appear to directly influence SHBG levels. Copyright Georg Thieme Verlag KG Rudigerstrase 14, 70469 Stuttgart, Germany.
+Other Abstract
+ Publisher
+ BACKGROUND: Low levels of SHBG have become a marker for insulin resistance and diabetes. Babies born to mothers who are obese, have diabetes, or smoke during pregnancy are at greater risk of developing obesity and diabetes later in life.
+ AIMS: To examine the impact of maternal obesity, diabetes and smoking on SHBG levels in newborns.
+ STUDY DESIGN: This cross-sectional study is part of an ongoing multicenter, longitudinal study.
+ SUBJECTS: 98 healthy newborns and their parents, including 16 mothers with diabetes and 31 mothers with a smoking history.
+ OUTCOME MEASURES: Cord blood and second day venipuncture samples were collected for measurement of SHBG and insulin.
+ RESULTS: Babies born to mothers with diabetes had lower SHBG levels in cord blood [14.0 (8.9-20.4) vs. 19.6 (14.9-25.1) nmol/L; p=0.011] and on day 2 [18.8 (12.6-21.2) vs. 22.9 (17.1-29.1) nmol/L; p=0.015] than controls. Maternal diabetes remained negatively associated with SHBG levels in cord blood (p=0.02) and on day 2 (p=0.04) when adjusted for mothers' age, smoking status, pre-pregnancy weight and weight gain during pregnancy. SHBG levels in cord blood and day 2 samples were similar in babies born to mothers who were overweight-obese but not diabetic vs. normal weight, or were smokers when compared to non-smokers.
+ CONCLUSIONS: SHBG levels are lower in newborns born to mothers with diabetes than without diabetes, and may be a marker for babies' life-long risk for abnormal metabolic health. On the other hand, the adverse effects of tobacco smoke on the fetus do not appear to directly influence SHBG levels.
+ Language: German
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1055%2fa-1375-4176
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aydin&issn=0947-7349&title=Experimental+%26+Clinical+Endocrinology+%26+Diabetes&atitle=Impact+of+Smoking%2C+Obesity+and+Maternal+Diabetes+on+SHBG+Levels+in+Newborns.&volume=130&issue=5&spage=335&epage=342&date=2022&doi=10.1055%2Fa-1375-4176&pmid=33618372&sid=OVID:medline
+
+<638>
+Unique Identifier
+ 33506692
+Title
+ The impact of exercise training versus caloric restriction on inflammation markers: a systemic review and meta-analysis.
+Source
+ Critical Reviews in Food Science & Nutrition. 62(15):4226-4241, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khalafi M; Symonds ME; Akbari A
+Authors Full Name
+ Khalafi, Mousa; Symonds, Michael E; Akbari, Amir.
+Institution
+ Khalafi, Mousa. Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.
+ Symonds, Michael E. The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.
+ Akbari, Amir. Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.
+MeSH Subject Headings
+ Biomarkers
+ *Caloric Restriction
+ Exercise
+ Humans
+ Inflammation
+ Interleukin-6
+ Obesity/th [Therapy]
+ Overweight/th [Therapy]
+ *Overweight
+ Tumor Necrosis Factor-alpha
+Keyword Heading
+ Caloric restriction
+ exercise training
+ inflammation
+ obesity
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with an increased risk of chronic, low-grade systematic inflammation for which exercise training (EX) and caloric restriction (CR) are potential treatments. We therefore performed a systematic meta-analysis to compare the effect of EX vs. CR and EX + CR vs. CR on inflammation markers in overweight and obese individuals. PubMed, Scopus, Web of Science and the Cochrane were searched up to April 2020 for EX vs. CR or EX + CR vs. CR interventions studies on inflammatory makers i.e. CRP, IL-6 and TNF-alpha in overweight and obese individuals. Standardized mean differences and 95% confidence intervals were calculated. Thirty two articles (reporting 38 trials) involving 2108 participants were included in the meta-analysis. Based on studies that directly compared EX and CR, there were no evidence for an effect of EX on IL-6 (p = 0.20) and TNF-alpha (p = 0.58), when compared with a CR. However, when compared to EX, CR has a statistically greater benefit on CRP (p = 0.01). In those studies, directly comparing EX + CR and CR, EX + CR caused a larger decrease in TNF-alpha (p = 0.002) and IL-6 (p = 0.02) and tended to decrease CRP (p = 0.06) when compared with CR. These results suggest that a combination of EX and CR may be more effective than CR alone at reducing inflammatory cytokines and CRP in overweight and obese individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f10408398.2021.1873732
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khalafi&issn=1040-8398&title=Critical+Reviews+in+Food+Science+%26+Nutrition&atitle=The+impact+of+exercise+training+versus+caloric+restriction+on+inflammation+markers%3A+a+systemic+review+and+meta-analysis.&volume=62&issue=15&spage=4226&epage=4241&date=2022&doi=10.1080%2F10408398.2021.1873732&pmid=33506692&sid=OVID:medline
+
+<639>
+Unique Identifier
+ 33465489
+Title
+ Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities.
+Source
+ Translational Research: The Journal Of Laboratory & Clinical Medicine. 239:85-102, 2022 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Camino T; Lago-Baameiro N; Bravo SB; Molares-Vila A; Sueiro A; Couto I; Baltar J; Casanueva EF; Pardo M
+Authors Full Name
+ Camino, Tamara; Lago-Baameiro, Nerea; Bravo, Susana Belen; Molares-Vila, Alberto; Sueiro, Aurelio; Couto, Ivan; Baltar, Javier; Casanueva, Eelipe F; Pardo, Maria.
+Institution
+ Camino, Tamara. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
+ Lago-Baameiro, Nerea. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
+ Bravo, Susana Belen. Unidad de Proteomica, Instituto de Investigacion Sanitaria de Santiago (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
+ Molares-Vila, Alberto. Bioinformatics Platform, Instituto de Investigacion Sanitaria de Santiago (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
+ Sueiro, Aurelio. Grupo Endocrinologia Molecular y Celular, Instituto de Investigacion Sanitaria de Santiago (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Spain.
+ Couto, Ivan. Servicio de Cirugia Plastica y Reparadora, Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
+ Baltar, Javier. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain; Servicio de Cirugia General, Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
+ Casanueva, Eelipe F. Grupo Endocrinologia Molecular y Celular, Instituto de Investigacion Sanitaria de Santiago (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Spain; CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain.
+ Pardo, Maria. Grupo Obesidomica, Area de Endocrinologia, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestion Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain; CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain. Electronic address: maruxapardo@hotmail.com.
+MeSH Subject Headings
+ *Adipose Tissue, White/me [Metabolism]
+ Adipose Tissue, White/pa [Pathology]
+ Adult
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Extracellular Matrix Proteins/me [Metabolism]
+ *Extracellular Vesicles/me [Metabolism]
+ Female
+ Humans
+ Intercellular Signaling Peptides and Proteins/bl [Blood]
+ Intra-Abdominal Fat/me [Metabolism]
+ Intra-Abdominal Fat/pa [Pathology]
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Obesity, Morbid/me [Metabolism]
+ Obesity, Morbid/pa [Pathology]
+ Proteins/an [Analysis]
+ *Proteins/me [Metabolism]
+ Subcutaneous Fat/me [Metabolism]
+ Subcutaneous Fat/pa [Pathology]
+ Syntenins/me [Metabolism]
+ Transforming Growth Factor beta/me [Metabolism]
+Abstract
+ Extracellular vesicles (EVs) have been recently postulated as key players in metabolic disorders emerging as an alternative way of paracrine/endocrine communication. However, the nature of EVs shed by adipose tissue (AT) and their role in obesity is still very limited. Here, we isolated human morbid obese visceral (VAT) and subcutaneous (SAT) whole AT shed EVs from donors submitted to bariatric surgery to characterize their protein cargo by qualitative and quantitative/SWATH mass spectrometry analysis. We identified 574 different proteins shed by morbid obese VAT and 401 proteins in those from SAT, establishing the first obese AT EV proteome reference map. Only 50% of identified proteins in VAT vesicles were common to those in SAT; additionally, EVs shed by obese VAT showed more AT and obesity-related adipokines than SAT. Functional classification shows that obese VAT vesicles exhibit an enrichment of proteins implicated in AT inflammation and insulin resistance such as TGFBI, CAVN1, CD14, mimecan, thrombospondin-1, FABP-4 or AHNAK. Selected candidate biomarkers from the quantitative-SWATH analysis were validated in EVs from independent morbid obese and from moderate obese to lean individuals showing that morbid obese VAT vesicles are characterized by a diminution of syntenin 1 and the elevation of TGFBI and mimecan. Interestingly, TGFBI and mimecan containing vesicles could be detected and quantified at circulating level in plasma. Thus, a significant elevation of -TGFBI-EVs was detected on those obese patients with a history of T2D compared to nondiabetic, and an augmentation of mimecan-EVs in obese plasma compared to those in healthy lean individuals. Thus, we conclude that obese AT release functional EVs carrying AT and obesity candidate biomarkers which vary regarding the AT of origin. Our findings suggest that circulating EV-TGFBI may facilitate monitoring T2D status in obese patients, and EV-mimecan may be useful to track adiposity, and more precisely, visceral obesity. Copyright © 2021 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Extracellular Matrix Proteins). 0 (Intercellular Signaling Peptides and Proteins). 0 (OGN protein, human). 0 (Proteins). 0 (SDCBP protein, human). 0 (Syntenins). 0 (Transforming Growth Factor beta). 148710-76-3 (betaIG-H3 protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Video-Audio Media.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.trsl.2021.01.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Camino&issn=1878-1810&title=Translational+Research%3A+The+Journal+Of+Laboratory+%26+Clinical+Medicine&atitle=Human+obese+white+adipose+tissue+sheds+depot-specific+extracellular+vesicles+and+reveals+candidate+biomarkers+for+monitoring+obesity+and+its+comorbidities.&volume=239&issue=&spage=85&epage=102&date=2022&doi=10.1016%2Fj.trsl.2021.01.006&pmid=33465489&sid=OVID:medline
+
+<640>
+Unique Identifier
+ 33448903
+Title
+ Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity.
+Source
+ Nutritional Neuroscience. 25(7):1437-1452, 2022 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Edwards CG; Walk AM; Thompson SV; Reeser GE; Dilger RN; Erdman JW Jr; Burd NA; Holscher HD; Khan NA
+Author NameID
+ Dilger, Ryan N; ORCID: https://orcid.org/0000-0003-2538-2845
+ Holscher, Hannah D; ORCID: https://orcid.org/0000-0003-4918-2426
+ Khan, Naiman A; ORCID: https://orcid.org/0000-0002-6135-9389
+Authors Full Name
+ Edwards, Caitlyn G; Walk, Anne M; Thompson, Sharon V; Reeser, Ginger E; Dilger, Ryan N; Erdman, John W Jr; Burd, Nicholas A; Holscher, Hannah D; Khan, Naiman A.
+Institution
+ Edwards, Caitlyn G. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Walk, Anne M. Department of Psychology, Eastern Illinois University, Charleston, IL, USA.
+ Thompson, Sharon V. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Reeser, Ginger E. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Dilger, Ryan N. Department of Animal Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Erdman, John W Jr. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Erdman, John W Jr. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Burd, Nicholas A. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Burd, Nicholas A. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Holscher, Hannah D. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Holscher, Hannah D. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Holscher, Hannah D. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Khan, Naiman A. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Khan, Naiman A. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+ Khan, Naiman A. Neuroscience Program, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Choline
+ Cognition
+ Diet
+ Humans
+ *Lutein
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Overweight
+ Zeaxanthins
+Keyword Heading
+ Carotenoids
+ MPOD
+ biomarker
+ cognition
+ cognitive control
+ electroencephalography
+ macular pigmentation
+ phosphatidylcholine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The xanthophyll carotenoids lutein+zeaxanthin and the dietary component choline have been linked to benefits in cognition. However, knowledge on the interactive influence of these dietary components on cognitive function is sparse.
+
+ DESIGN: 80 middle-aged adults with overweight and obesity (Body Mass Index: (BMI) >=25.0 kg/m2), completed 7-day diet records, venous blood draws, heterochromatic flicker photometry, assessment of intelligence quotient (IQ), and a cognitive flexibility task while undergoing electroencephalographic recording for event-related potential (ERP) extraction. Multiplicative interaction terms and hierarchical linear regressions, controlling for age, BMI, sex, annual household income, and IQ were utilized to assess independent and interactive contributions of dietary and biomarker data on Switch task outcomes.
+
+ RESULTS: Higher intake of lutein+zeaxanthin and choline was associated interactively, but not independently, with faster reaction time (RT), after controlling for pertinent covariates. Dietary intake of lutein+zeaxanthin and choline was associated with serum lutein concentrations, but not with plasma choline metabolites nor macular pigmentation. Plasma phosphatidylcholine (PC) concentrations were associated with higher accuracy in Switch trials, while no other biomarkers were associated with cognitive outcomes. Dietary intake and biomarker data were not related to the N2 nor P3 ERP component.
+
+ CONCLUSIONS: Among a sample of adults with overweight and obesity, greater intake of choline and lutein+zeaxanthin was associated with faster performance on a cognitive flexibility task. Future work examining methods of increasing consumption of both of these dietary components as a possible means of improving or maintaining cognitive flexibility among adults with overweight and obesity is therefore warranted.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Zeaxanthins). N91BDP6H0X (Choline). X72A60C9MT (Lutein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f1028415X.2020.1866867
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Edwards&issn=1028-415X&title=Nutritional+Neuroscience&atitle=Dietary+lutein+plus+zeaxanthin+and+choline+intake+is+interactively+associated+with+cognitive+flexibility+in+middle-adulthood+in+adults+with+overweight+and+obesity.&volume=25&issue=7&spage=1437&epage=1452&date=2022&doi=10.1080%2F1028415X.2020.1866867&pmid=33448903&sid=OVID:medline
+
+<641>
+Unique Identifier
+ 33397240
+Title
+ Growth Differentiation Factor-15 as a Biomarker of Obese Pre-diabetes and Type 2 Diabetes Mellitus in Indian Subjects: A Case-control Study.
+Source
+ Current Diabetes Reviews. 18(1):e010321189862, 2022.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Roy D; Purohit P; Modi A; Khokhar M; Shukla RKG; Chaudhary R; Sankanagoudar S; Sharma P
+Authors Full Name
+ Roy, Dipayan; Purohit, Purvi; Modi, Anupama; Khokhar, Manoj; Shukla, Ravindra Kumar Gayaprasad; Chaudhary, Ramkaran; Sankanagoudar, Shrimanjunath; Sharma, Praveen.
+Institution
+ Roy, Dipayan. Department of Biochemistry, AIIMS, Jodhpur, Rajasthan,India.
+ Purohit, Purvi. Department of Biochemistry, AIIMS, Jodhpur, Rajasthan, India.
+ Modi, Anupama. Department of Biochemistry, AIIMS, Jodhpur, Rajasthan,India.
+ Khokhar, Manoj. Department of Biochemistry, AIIMS, Jodhpur, Rajasthan,India.
+ Shukla, Ravindra Kumar Gayaprasad. Department of Endocrinology and Metabolism, AIIMS, Jodhpur, Rajasthan,India.
+ Chaudhary, Ramkaran. Department of General Surgery, AIIMS, Jodhpur, Rajasthan,India.
+ Sankanagoudar, Shrimanjunath. Department of Biochemistry, AIIMS, Jodhpur, Rajasthan,India.
+ Sharma, Praveen. Department of Biochemistry, AIIMS, Jodhpur, Rajasthan,India.
+MeSH Subject Headings
+ Biomarkers
+ Case-Control Studies
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2
+ Humans
+ Obesity/co [Complications]
+ Prediabetic State/co [Complications]
+ Prediabetic State/di [Diagnosis]
+ *Prediabetic State
+ Prospective Studies
+Keyword Heading
+ GDF15
+ MIC-1
+ biomarker
+ cutpointr
+ obesity
+ type 2 diabetes
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Type 2 diabetes mellitus (T2DM) is an ever-growing epidemic in India and poses significant morbidity, mortality, and socioeconomic burden.
+
+ INTRODUCTION: Growth differentiation factor-15 (GDF15) is a stress-responsive cytokine, increased in T2DM patients compared to control subjects without the disease. We aimed to assess whether serum GDF15 and adipose tissue GDF15 expression can differentiate between obese pre-diabetes and T2DM and control populations.
+
+ METHODOLOGY: We recruited 156 individuals including 73 type 2 diabetes, 30 pre-diabetes, and 53 healthy controls. Clinical history, anthropometric measurements and biochemical profiling were taken. Insulin resistance indices were calculated following HOMA models. Serum GDF15 was measured by sandwich ELISA. Visceral adipose tissue (VAT) expression of GDF15 was observed in 17 T2DM patients and 29 controls using SYBR Green chemistry in RT-PCR using GAPDH as the housekeeping gene. The data were analyzed on R programming platform using RStudio.
+
+ RESULTS: Serum GDF15 was significantly higher (p<0.001) in T2DM subjects (median 1445.47 pg/mL) compared to pre-diabetes (627.85 pg/mL) and healthy controls (609.01 pg/mL). Using the DELTADELTACt method, the VAT GDF15 expression was 1.54 fold and 1.57 fold upregulated in T2DM (n=17) compared to control subjects (n=29), and obese (n=12) compared to non-obese (n=34)subjects, respectively. The optimal cut-off point following Youden's index method was found to be 868.09 pg/mL. ROC curve analysis revealed that serum GDF15 had a sensitivity, specificity, and area under the curve (AUC) of 90.41%, 79.52%, and 0.892 respectively. GDF15 levels were significantly associated with age, BMI, HbA1c, fasting blood sugar, and insulin resistance indices.
+
+ CONCLUSION: Hence, serum GDF15 is a biomarker for T2DM patients in our study population from Western India. However, larger prospective cohorts are necessary to validate this claim. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.2174%2f1573399817666210104101739
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Roy&issn=1573-3998&title=Current+Diabetes+Reviews&atitle=Growth+Differentiation+Factor-15+as+a+Biomarker+of+Obese+Pre-diabetes+and+Type+2+Diabetes+Mellitus+in+Indian+Subjects%3A+A+Case-control+Study.&volume=18&issue=1&spage=e010321189862&epage=&date=2022&doi=10.2174%2F1573399817666210104101739&pmid=33397240&sid=OVID:medline
+
+<642>
+Unique Identifier
+ 33009497
+Title
+ Association of aging and obesity with decreased 17-hydroxyprogesterone, a serum biomarker of intratesticular testosterone.
+Source
+ International Journal of Impotence Research. 34(1):44-49, 2022 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lima TFN; Frech FS; Blachman-Braun R; Rakitina E; Patel P; Ramasamy R
+Author NameID
+ Lima, Thiago Fernandes Negris; ORCID: http://orcid.org/0000-0002-7410-7025
+ Frech, Fabio Stefano; ORCID: http://orcid.org/0000-0002-0689-6464
+ Ramasamy, Ranjith; ORCID: http://orcid.org/0000-0003-1387-7904
+Authors Full Name
+ Lima, Thiago Fernandes Negris; Frech, Fabio Stefano; Blachman-Braun, Ruben; Rakitina, Evgeniya; Patel, Premal; Ramasamy, Ranjith.
+Institution
+ Lima, Thiago Fernandes Negris. Department of Urology, University of Miami Miller School of Medicine, Miami, FL, United States. thiagofernandesnl@gmail.com.
+ Frech, Fabio Stefano. Department of Urology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Blachman-Braun, Ruben. Department of Urology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Rakitina, Evgeniya. Department of Urology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Patel, Premal. Department of Urology, University of Manitoba, Winnipeg, MB, Canada.
+ Ramasamy, Ranjith. Department of Urology, University of Miami Miller School of Medicine, Miami, FL, United States.
+MeSH Subject Headings
+ 17-alpha-Hydroxyprogesterone
+ Adult
+ Aging
+ Biomarkers
+ Cross-Sectional Studies
+ Humans
+ Male
+ Obesity
+ Testis/ch [Chemistry]
+ *Testis
+ *Testosterone
+Abstract
+ Obesity's negative association with serum testosterone can be explained by either decreasing luteinizing hormone (LH) production from the pituitary gland and/or directly impacting intratesticular testosterone production. We hypothesize that obesity will negatively impact intratesticular testosterone levels when compared to those of non-obese men. We performed a cross-sectional analysis of men with symptoms of testosterone deficiency and male infertility between July 2018 and April 2020 to evaluate the association between body mass index (BMI) and age with intratesticular testosterone (using serum 17-hydroxyprogesterone (17-OHP) as a biomarker), and between BMI with LH. Univariable and multiple linear regression analysis were performed using confounding variables to predict 17-OHP and testosterone. A total of 340 men were selected. Median age was 38 [33-44] years, BMI 27.8 [25.4-31.1] kg/m2, serum testosterone 363 [256.3-469.6] ng/dl, 17-OHP 60.5 [39.3-85.8] ng/dl, and LH 4.2 [2.8-5.7] mIU/ml. Older and obese men had lower testosterone compared to younger and non-obese men. Interestingly, increasing age and higher BMI were associated with lower 17-OHP (p < 0.001). Contrarily, age and BMI were not associated with LH levels (p = 0.478). In conclusion, obesity and aging negatively affected 17-OHP independent of LH, suggesting a possible direct effect on testicular function, rather than a secondary effect from a decline in pituitary signaling. Copyright © 2020. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3XMK78S47O (Testosterone). 68-96-2 (17-alpha-Hydroxyprogesterone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1038%2fs41443-020-00358-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lima&issn=0955-9930&title=International+Journal+of+Impotence+Research&atitle=Association+of+aging+and+obesity+with+decreased+17-hydroxyprogesterone%2C+a+serum+biomarker+of+intratesticular+testosterone.&volume=34&issue=1&spage=44&epage=49&date=2022&doi=10.1038%2Fs41443-020-00358-8&pmid=33009497&sid=OVID:medline
+
+<643>
+Unique Identifier
+ 32928009
+Title
+ Maternal weight as an additional first trimester spina bifida screening marker.
+Source
+ Journal of Maternal-Fetal & Neonatal Medicine. 35(17):3353-3358, 2022 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Arbuzova S; Nikolenko M; Cuckle H
+Authors Full Name
+ Arbuzova, Svetlana; Nikolenko, Margaryta; Cuckle, Howard.
+Institution
+ Arbuzova, Svetlana. Center of Medical Genetics and Prenatal Diagnosis, Mariupol, Ukraine.
+ Nikolenko, Margaryta. Center of Medical Genetics and Prenatal Diagnosis, Mariupol, Ukraine.
+ Cuckle, Howard. Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
+MeSH Subject Headings
+ Biomarkers
+ *Body Weight
+ Case-Control Studies
+ Female
+ Humans
+ Obesity
+ Pregnancy
+ Pregnancy Trimester, First
+ *Prenatal Diagnosis
+ Spinal Dysraphism/di [Diagnosis]
+ *Spinal Dysraphism
+ *alpha-Fetoproteins
+Keyword Heading
+ Maternal weight
+ first trimester
+ marker
+ screening
+ spina bifida
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To evaluate first trimester maternal weight as a spina bifida screening marker.
+
+ METHODS: Case-control study of spina bifida and unaffected pregnancies; cases were from national records and controls from women referred to prenatal screening centers in the Ukraine. The median and inter-quartile range of weight, body mass index (BMI) and the obesity rate (BMI >= 30 kg/m2) were compared. Discriminatory power was assessed by logistic regression. Gaussian modeling was used to predict the additional spina bifida detection when weight was included as a screening marker risk in addition to first trimester biparietal diameter (BPD) and serum alpha-fetoprotein (AFP).
+
+ RESULTS: There were 97 cases and 274 controls. The distribution of maternal weight was increased in cases by 3 kg, on average, about 5% (p < .05); BMI was increased about 8% (p < .005). Some 15% of cases were obese compared with 6.9% of controls (p < .02). In logistic regression including BMI and maternal age, 29% cases and 9.8% controls had high risk of spina bifida. Modeling predicted that incorporating weight would increase the detection rate compared with BPD and AFP alone by 3% and BMI would increase it by 4%.
+
+ CONCLUSION: Incorporating maternal weight into first trimester spina bifida screening protocols will increase detection.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (alpha-Fetoproteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f14767058.2020.1818217
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Arbuzova&issn=1476-4954&title=Journal+of+Maternal-Fetal+%26+Neonatal+Medicine&atitle=Maternal+weight+as+an+additional+first+trimester+spina+bifida+screening+marker.&volume=35&issue=17&spage=3353&epage=3358&date=2022&doi=10.1080%2F14767058.2020.1818217&pmid=32928009&sid=OVID:medline
+
+<644>
+Unique Identifier
+ 32536220
+Title
+ Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants.
+Source
+ Archives of Physiology & Biochemistry. 128(6):1461-1466, 2022 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Benbaibeche H; Hichami A; Oudjit B; Haffaf EM; Kacimi G; Koceir EA; Khan NA
+Authors Full Name
+ Benbaibeche, Hassiba; Hichami, Aziz; Oudjit, Brahim; Haffaf, El Mahdi; Kacimi, Ghouti; Koceir, Elhadj Ahmed; Khan, Naim Akhtar.
+Institution
+ Benbaibeche, Hassiba. Departement des Sciences de la Nature Et de la Vie, Faculte des Sciences, Universite d'Alger, Algerie.
+ Benbaibeche, Hassiba. Bioenergetics and Intermediary Metabolism Laboratory, Department of Biological Sciences and Physiology, Faculty of Biologic Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.
+ Hichami, Aziz. Physiologie de la Nutrition & Toxicologie, UMR 1231 INSERM/Universite de Bourgogne/Agro-Sup, Dijon, France.
+ Oudjit, Brahim. Mohamed Seghir Nekkache Hospital, Algiers, Algeria.
+ Haffaf, El Mahdi. Mohamed Seghir Nekkache Hospital, Algiers, Algeria.
+ Kacimi, Ghouti. Mohamed Seghir Nekkache Hospital, Algiers, Algeria.
+ Koceir, Elhadj Ahmed. Bioenergetics and Intermediary Metabolism Laboratory, Department of Biological Sciences and Physiology, Faculty of Biologic Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.
+ Khan, Naim Akhtar. Physiologie de la Nutrition & Toxicologie, UMR 1231 INSERM/Universite de Bourgogne/Agro-Sup, Dijon, France.
+MeSH Subject Headings
+ Humans
+ Male
+ Algeria
+ Biomarkers
+ Cytokines/ge [Genetics]
+ Interleukin-6
+ *MicroRNAs
+ Obesity/ge [Genetics]
+ Tumor Necrosis Factor-alpha/ge [Genetics]
+ *Tumor Necrosis Factor-alpha
+Keyword Heading
+ CD36
+ adipocytokines
+ miR-146a
+ miR-21
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. We assessed the association of mir-146a and mir-21 with inflammatory states in Algerian young participants.
+
+ METHODS: Our study included male obese, without co-morbidities (n = 29), and healthy participants (n = 13). miRNA and CD36 expression was measured by real-time RT-PCR, respectively, in serum and blood.
+
+ RESULTS: miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. Interestingly, miR-146a and miR-21 concentrations were negatively correlated to IL-6, TNF-alpha, and CD36 in obese participants.
+
+ CONCLUSION: We demonstrate that the downregulation of miR-146a and miR-21 was associated with upregulation of inflammatory state and increased CD36 expression in obese participants.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Interleukin-6). 0 (MicroRNAs). 0 (MIRN21 microRNA, human). 0 (Tumor Necrosis Factor-alpha). 0 (MIRN146 microRNA, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1080%2f13813455.2020.1775655
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Benbaibeche&issn=1381-3455&title=Archives+of+Physiology+%26+Biochemistry&atitle=Circulating+mir-21+and+mir-146a+are+associated+with+increased+cytokines+and+CD36+in+Algerian+obese+male+participants.&volume=128&issue=6&spage=1461&epage=1466&date=2022&doi=10.1080%2F13813455.2020.1775655&pmid=32536220&sid=OVID:medline
+
+<645>
+Unique Identifier
+ 32407803
+Title
+ Does light-intensity physical activity moderate the relationship between sitting time and adiposity markers in adolescents?.
+Source
+ Journal of Sport & Health Science. 11(5):613-619, 2022 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Contardo Ayala AM; Salmon J; Dunstan DW; Arundell L; Timperio A
+Authors Full Name
+ Contardo Ayala, Ana Maria; Salmon, Jo; Dunstan, David W; Arundell, Lauren; Timperio, Anna.
+Institution
+ Contardo Ayala, Ana Maria. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIA 3125, Australia. Electronic address: a.contardoayala@deakin.edu.au.
+ Salmon, Jo. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIA 3125, Australia.
+ Dunstan, David W. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIA 3125, Australia; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIA 3004, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIA 3000, Australia.
+ Arundell, Lauren. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIA 3125, Australia.
+ Timperio, Anna. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIA 3125, Australia.
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ Biomarkers
+ Cross-Sectional Studies
+ Exercise
+ Humans
+ Obesity/pc [Prevention & Control]
+ *Sedentary Behavior
+Keyword Heading
+ Adolescents
+ Anthropometric measures
+ Obesity
+ Physical activity
+ Sedentary behavior
+ Sitting time
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: While the relationship between sedentary time and adiposity markers may be independent of moderate-to-vigorous intensity physical activity (MVPA) among adolescents, little is known about the role of light-intensity physical activity (LIPA) in this relationship. The aim of this cross-sectional study was to examine whether device-measured LIPA and MVPA moderate the associations between objectively measured sitting time and adiposity markers (body mass index (BMI)) and waist circumference (WC)) among adolescents.
+
+ METHODS: This study included accelerometer and inclinometer data obtained from 219 adolescents (age=14.9 +/- 1.6 years, mean +/- SD), collected during 2014 and 2015 in Melbourne, Australia. ActiGraph GT3X accelerometers were used to determine time spent in total-LIPA (101 counts/min to 3.99 metabolic equivalents (METs)) was dichotomized into low-LIPA (101-799 counts/min) and high LIPA (800 counts/min to 3.99 METs), and MVPA (>= 4 METs). The average time spent sitting was obtained from activPAL inclinometers. Anthropometric measures were assessed by trained staff. Interactions between sitting and total-LIPA, low-LIPA, high-LIPA, and MVPA on BMI z-score (zBMI) and WC z-score (zWC), respectively, were examined using linear regression, adjusting for age and sex; and moderation by total-LIPA, low-LIPA, high-LIPA, and MVPA were examined by adding interaction terms. Significant interaction effects were probed by comparing associations at the mean and at 1 SD below and above the mean.
+
+ RESULTS: Total-LIPA significantly moderated the association between sitting time and zBMI, and low-LIPA significantly moderated the association between sitting time and zBMI and zWC. No other associations were found for total-LIPA, high-LIPA, or MVPA. Specifically, at high levels of total-LIPA (+1 SD), there is a negative association between sitting time and zBMI. In addition, at high levels of low-LIPA (+1 SD), there is a negative association between sitting time and zBMI and zWC.
+
+ CONCLUSION: Associations between sitting and adiposity depended on time spent in total-LIPA and low-LIPA, but not high-LIPA or MVPA. Results suggest that increasing time spent in LIPA may provide protection from the deleterious effects of sitting on adiposity markers among adolescents. Experimental evidence is needed to support these conclusions. Copyright © 2020. Production and hosting by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2022
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1016%2fj.jshs.2020.04.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Contardo+Ayala&issn=2213-2961&title=Journal+of+Sport+%26+Health+Science&atitle=Does+light-intensity+physical+activity+moderate+the+relationship+between+sitting+time+and+adiposity+markers+in+adolescents%3F.&volume=11&issue=5&spage=613&epage=619&date=2022&doi=10.1016%2Fj.jshs.2020.04.002&pmid=32407803&sid=OVID:medline
+
+<646>
+Unique Identifier
+ 34302728
+Title
+ Associations of Body Mass Index and Waist Circumference in Young Adulthood with Later Life Incident Diabetes.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 106(12):e5011-e5020, 2021 11 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nair N; Vittinghoff E; Pletcher MJ; Oelsner EC; Allen NB; Ndumele CE; West NA; Strotmeyer ES; Mukamal KJ; Siscovick DS; Biggs ML; Laferrere B; Moran AE; Zhang Y
+Author NameID
+ Nair, Nandini; ORCID: https://orcid.org/0000-0002-7958-8753
+ Vittinghoff, Eric; ORCID: https://orcid.org/0000-0001-8535-0920
+ Zhang, Yiyi; ORCID: https://orcid.org/0000-0002-8663-5001
+Authors Full Name
+ Nair, Nandini; Vittinghoff, Eric; Pletcher, Mark J; Oelsner, Elizabeth C; Allen, Norrina B; Ndumele, Chiadi E; West, Nancy A; Strotmeyer, Elsa S; Mukamal, Kenneth J; Siscovick, David S; Biggs, Mary L; Laferrere, Blandine; Moran, Andrew E; Zhang, Yiyi.
+Institution
+ Nair, Nandini. Division of Endocrinology; Columbia University, New York, NY, USA.
+ Vittinghoff, Eric. Department of Epidemiology and Biostatistics; University of California, San Francisco, San Francisco, CA, USA.
+ Pletcher, Mark J. Department of Epidemiology and Biostatistics; Department of Medicine; University of California, San Francisco, San Francisco, CA, USA.
+ Oelsner, Elizabeth C. Division of General Medicine; Columbia University, New York, NY, USA.
+ Allen, Norrina B. Department of Preventative Medicine; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
+ Ndumele, Chiadi E. Division of Cardiology; Department of Epidemiology; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
+ West, Nancy A. Division of Epidemiology, University of Utah, Salt Lake City, UT, USA.
+ Strotmeyer, Elsa S. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
+ Mukamal, Kenneth J. Division of General Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
+ Siscovick, David S. New York Academy of Medicine, New York, NY, USA.
+ Biggs, Mary L. Department of Biostatistics, University of Washington, Seattle, WA, USA.
+ Laferrere, Blandine. New York Obesity Research Center; Division of Endocrinology; Columbia University, New York, NY, USA.
+ Moran, Andrew E. Division of General Medicine; Columbia University, New York, NY, USA.
+ Zhang, Yiyi. Division of General Medicine; Columbia University, New York, NY, USA.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Diabetes Mellitus/bl [Blood]
+ *Diabetes Mellitus/ep [Epidemiology]
+ Diabetes Mellitus/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Risk Factors
+ United States/ep [Epidemiology]
+ *Waist Circumference
+ Young Adult
+Keyword Heading
+ body mass index
+ diabetes
+ waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: The independent contribution of young adult exposure to overweight and obesity to later-life incident diabetes is not well studied.
+
+ OBJECTIVE: To assess the associations of exposures to elevated body mass index (BMI) and waist circumference (WC) in young adulthood (ages 18-39 years) with incident diabetes later in life (>=40 years).
+
+ DESIGN: Pooled data from 6 US prospective cohorts (Atherosclerosis Risk in Communities Study, Cardiovascular Risk Development in Young Adults Study, Cardiovascular Health Study, (4) Framingham Heart Study Offspring Cohort, (5) Health, Aging and Body Composition Study, and (6) Multi-Ethnic Study of Atherosclerosis.
+
+ SETTING: Population-based cohort studies.
+
+ PARTICIPANTS: 30 780 participants (56.1% female, 69.8% non-Hispanic white) without a diagnosis of diabetes by age 40.
+
+ INTERVENTIONS: We imputed BMI and WC trajectories from age 18 for every participant and estimated time-weighted average exposures to BMI or WC during young adulthood and later life.
+
+ MAIN OUTCOME MEASURE(S): Incident diabetes defined as fasting glucose >=126 mg/dL, nonfasting glucose >=200 mg/dL, or use of diabetes medications.
+
+ RESULTS: During a 9-year median follow-up, 4323 participants developed incident diabetes. Young adult BMI and WC were associated with later-life incident diabetes after controlling for later-life exposures [hazard ratios (HR) 1.99 for BMI >= 30 kg/m2 and 2.13 for WC > 88cm (women)/>102cm (men) compared to normal ranges]. Young adult homeostatic model of insulin resistance mediated 49% and 44% of the association between BMI and WC with later-life incident diabetes. High-density lipoproteins and triglycerides mediated a smaller proportion of these associations.
+
+ CONCLUSIONS: Elevated BMI and WC during young adulthood were independently associated with later-life incident diabetes. Insulin resistance may be a key mediator. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1210%2fclinem%2fdgab551
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nair&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Associations+of+Body+Mass+Index+and+Waist+Circumference+in+Young+Adulthood+with+Later+Life+Incident+Diabetes.&volume=106&issue=12&spage=e5011&epage=e5020&date=2021&doi=10.1210%2Fclinem%2Fdgab551&pmid=34302728&sid=OVID:medline
+
+<647>
+Unique Identifier
+ 34159759
+Title
+ Six-year changes in N-terminal pro-brain natriuretic peptide and changes in weight and risk of obesity.
+Source
+ Obesity. 29(7):1215-1222, 2021 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sbaraini da Silva M; Lazo M; Daya NR; Tang O; Schaan BD; Ballantyne CM; Ndumele C; Selvin E
+Author NameID
+ Daya, Natalie R; ORCID: https://orcid.org/0000-0002-2257-0480
+Authors Full Name
+ Sbaraini da Silva, Mariana; Lazo, Mariana; Daya, Natalie R; Tang, Olive; Schaan, Beatriz D; Ballantyne, Christie M; Ndumele, Chiadi; Selvin, Elizabeth.
+Institution
+ Sbaraini da Silva, Mariana. Postgraduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grade do Sul, Brazil.
+ Lazo, Mariana. Department of Medicine, Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
+ Lazo, Mariana. Department of Community Health and Prevention, Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.
+ Daya, Natalie R. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
+ Tang, Olive. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
+ Schaan, Beatriz D. Postgraduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grade do Sul, Brazil.
+ Schaan, Beatriz D. Department of Endocrinology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grade do Sul, Brazil.
+ Ballantyne, Christie M. Department of Medicine, Baylor College of Medicine, and Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA.
+ Ndumele, Chiadi. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
+ Selvin, Elizabeth. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
+MeSH Subject Headings
+ Biomarkers
+ Humans
+ *Natriuretic Peptide, Brain
+ Obesity/ep [Epidemiology]
+ *Peptide Fragments
+ Prospective Studies
+ Risk Factors
+Abstract
+ OBJECTIVE: The aim of this study was to study the prospective association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and changes in weight and obesity risk in a community-based population.
+
+ METHODS: Data from 9,681 participants from the Atherosclerosis Risk in Communities Study were analyzed at two time points 6 years apart. Among people without obesity at baseline, multivariable logistic regression models were used to examine the association between baseline levels of NT-proBNP and incident obesity. A multivariable linear regression model was used to examine the association between changes in NT-proBNP (visit 2 serum and visit 4 plasma samples) and changes in weight.
+
+ RESULTS: The prevalence of obesity increased from 28% to 35% in the 6-year follow-up period. Compared with individuals in the highest NT-proBNP quartile, those in the lowest were more likely to have obesity at baseline (odds ratio 1.25; 95% CI: 1.08-1.45) and, among people who did not have obesity at baseline, were more likely to develop obesity at follow-up (odds ratio 1.35; 95% CI: 1.07-1.69). Changes in NT-proBNP were inversely associated with weight change.
+
+ CONCLUSIONS: In this prospective study, lower levels of NT-proBNP were associated with higher risk of obesity, and changes in NT-proBNP were inversely associated with changes in weight. This suggests that natriuretic peptides or their pathways may be potential targets in the treatment of obesity. Copyright © 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1002%2foby.23181
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sbaraini+da+Silva&issn=1930-7381&title=Obesity&atitle=Six-year+changes+in+N-terminal+pro-brain+natriuretic+peptide+and+changes+in+weight+and+risk+of+obesity.&volume=29&issue=7&spage=1215&epage=1222&date=2021&doi=10.1002%2Foby.23181&pmid=34159759&sid=OVID:medline
+
+<648>
+Unique Identifier
+ 34454586
+Title
+ Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects.
+Source
+ Genome Medicine. 13(1):137, 2021 08 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li Y; Zhang Y; Hu Q; Egranov SD; Xing Z; Zhang Z; Liang K; Ye Y; Pan Y; Chatterjee SS; Mistretta B; Nguyen TK; Hawke DH; Gunaratne PH; Hung MC; Han L; Yang L; Lin C
+Author NameID
+ Lin, Chunru; ORCID: https://orcid.org/0000-0002-6473-8229
+Authors Full Name
+ Li, Yajuan; Zhang, Yaohua; Hu, Qingsong; Egranov, Sergey D; Xing, Zhen; Zhang, Zhao; Liang, Ke; Ye, Youqiong; Pan, Yinghong; Chatterjee, Sujash S; Mistretta, Brandon; Nguyen, Tina K; Hawke, David H; Gunaratne, Preethi H; Hung, Mien-Chie; Han, Leng; Yang, Liuqing; Lin, Chunru.
+Institution
+ Li, Yajuan. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
+ Zhang, Yaohua. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
+ Hu, Qingsong. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
+ Egranov, Sergey D. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
+ Xing, Zhen. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
+ Xing, Zhen. Current address: Sanofi U.S., Boston, MA, 02139, USA.
+ Zhang, Zhao. Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, 77030, USA.
+ Liang, Ke. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
+ Ye, Youqiong. Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, 77030, USA.
+ Pan, Yinghong. Department of Biochemistry and Biology, University of Houston, Houston, TX, 77204, USA.
+ Pan, Yinghong. Current address: UPMC Genome Center, Pittsburgh, PA, 15232, USA.
+ Chatterjee, Sujash S. Department of Biochemistry and Biology, University of Houston, Houston, TX, 77204, USA.
+ Mistretta, Brandon. Department of Biochemistry and Biology, University of Houston, Houston, TX, 77204, USA.
+ Nguyen, Tina K. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
+ Hawke, David H. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
+ Gunaratne, Preethi H. Department of Biochemistry and Biology, University of Houston, Houston, TX, 77204, USA.
+ Hung, Mien-Chie. Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical University, Taichung, 404, Taiwan.
+ Hung, Mien-Chie. Department of Biotechnology, Asia University, Taichung, 413, Taiwan.
+ Han, Leng. Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, 77030, USA.
+ Han, Leng. Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, 77030, USA.
+ Yang, Liuqing. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. lyang7@mdanderson.org.
+ Yang, Liuqing. Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. lyang7@mdanderson.org.
+ Yang, Liuqing. The Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. lyang7@mdanderson.org.
+ Lin, Chunru. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. clin2@mdanderson.org.
+ Lin, Chunru. Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. clin2@mdanderson.org.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Carrier Proteins
+ *Cell Differentiation/ge [Genetics]
+ Cells, Cultured
+ Disease Management
+ Disease Models, Animal
+ Disease Susceptibility
+ Dystrophin/ge [Genetics]
+ Dystrophin/me [Metabolism]
+ Fluorescent Antibody Technique/mt [Methods]
+ *Gain of Function Mutation
+ Genetic Therapy
+ Humans
+ Immunohistochemistry
+ Induced Pluripotent Stem Cells/me [Metabolism]
+ Mice
+ Mice, Knockout
+ *Muscle Development/ge [Genetics]
+ *Muscle, Skeletal/me [Metabolism]
+ Muscular Dystrophy, Duchenne/ge [Genetics]
+ Muscular Dystrophy, Duchenne/me [Metabolism]
+ Muscular Dystrophy, Duchenne/th [Therapy]
+ Obesity/di [Diagnosis]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Obesity/th [Therapy]
+ Phosphorylation
+ Protein Binding
+ *RNA, Long Noncoding/ge [Genetics]
+Keyword Heading
+ Dystrophin
+ H19
+ Long noncoding RNA
+ Obesity
+ RNA therapy
+ Skeletal muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Exercise training is well established as the most effective way to enhance muscle performance and muscle building. The composition of skeletal muscle fiber type affects systemic energy expenditures, and perturbations in metabolic homeostasis contribute to the onset of obesity and other metabolic dysfunctions. Long noncoding RNAs (lncRNAs) have been demonstrated to play critical roles in diverse cellular processes and diseases, including human cancers; however, the functional importance of lncRNAs in muscle performance, energy balance, and obesity remains elusive. We previously reported that the lncRNA H19 regulates the poly-ubiquitination and protein stability of dystrophin (DMD) in muscular dystrophy.
+
+ METHODS: Here, we identified mouse/human H19-interacting proteins using mouse/human skeletal muscle tissues and liquid chromatography-mass spectrometry (LC-MS). Human induced pluripotent stem-derived skeletal muscle cells (iPSC-SkMC) from a healthy donor and Becker Muscular Dystrophy (BMD) patients were utilized to study DMD post-translational modifications and associated proteins. We identified a gain-of-function (GOF) mutant of H19 and characterized the effects on myoblast differentiation and fusion to myotubes using iPSCs. We then conjugated H19 RNA gain-of-function oligonucleotides (Rgof) with the skeletal muscle enrichment peptide agrin (referred to as AGR-H19-Rgof) and evaluated AGR-H19-Rgof's effects on skeletal muscle performance using wild-type (WT) C57BL/6 J mice and its anti-obesity effects using high-fat diet (HFD)- and leptin deficiency-induced obese mouse models.
+
+ RESULTS: We demonstrated that both human and mouse H19 associated with DMD and that the H19 GOF exhibited enhanced interaction with DMD compared to WT H19. DMD was found to associate with serine/threonine-protein kinase MRCK alpha (MRCKalpha) and alpha-synuclein (SNCA) in iPSC-SkMC derived from BMD patients. Inhibition of MRCKalpha and SNCA-mediated phosphorylation of DMD antagonized the interaction between H19 and DMD. These signaling events led to improved skeletal muscle cell differentiation and myotube fusion. The administration of AGR-H19-Rgof improved the muscle mass, muscle performance, and base metabolic rate of WT mice. Furthermore, mice treated with AGR-H19-Rgof exhibited resistance to HFD- or leptin deficiency-induced obesity.
+
+ CONCLUSIONS: Our study suggested the functional importance of the H19 GOF mutant in enhancing muscle performance and anti-obesity effects. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Carrier Proteins). 0 (DMD protein, human). 0 (Dystrophin). 0 (H19 long non-coding RNA). 0 (RNA, Long Noncoding).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs13073-021-00937-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1756-994X&title=Genome+Medicine&atitle=Functional+significance+of+gain-of-function+H19+lncRNA+in+skeletal+muscle+differentiation+and+anti-obesity+effects.&volume=13&issue=1&spage=137&epage=&date=2021&doi=10.1186%2Fs13073-021-00937-4&pmid=34454586&sid=OVID:medline
+
+<649>
+Unique Identifier
+ 34155269
+Title
+ Long-term body mass trajectories and hypertension by sex among Chinese adults: a 24-year open cohort study.
+Source
+ Scientific Reports. 11(1):12915, 2021 06 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu R; Mi B; Zhao Y; Dang S; Yan H
+Authors Full Name
+ Liu, Ruru; Mi, Baibing; Zhao, Yaling; Dang, Shaonong; Yan, Hong.
+Institution
+ Liu, Ruru. Xi'an Center for Disease Control and Prevention, Xi'an, 710054, Shaanxi, China.
+ Liu, Ruru. Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, No. 76, Yanta West Road, Xi'an, 710061, Shaanxi, China.
+ Mi, Baibing. Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, No. 76, Yanta West Road, Xi'an, 710061, Shaanxi, China.
+ Zhao, Yaling. Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, No. 76, Yanta West Road, Xi'an, 710061, Shaanxi, China.
+ Dang, Shaonong. Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, No. 76, Yanta West Road, Xi'an, 710061, Shaanxi, China. tjdshn@xjtu.edu.cn.
+ Yan, Hong. Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, No. 76, Yanta West Road, Xi'an, 710061, Shaanxi, China. xjtu_yh.paper@aliyun.com.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers
+ *Body Mass Index
+ *Body Weight
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ Cohort Studies
+ Disease Susceptibility
+ Female
+ Follow-Up Studies
+ Humans
+ Hypertension/di [Diagnosis]
+ *Hypertension/ep [Epidemiology]
+ *Hypertension/et [Etiology]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Public Health Surveillance
+ Risk Assessment
+ Risk Factors
+Abstract
+ Evidence was limited on trajectory of body mass index (BMI) through adulthood and its association with hypertension. We aimed to evaluate their association by sex in large-scale study. Data were obtained from the China Health and Nutrition Survey (CHNS) from 1991 to 2015. Latent class trajectory analysis (LCTA) was used to capture BMI change trajectories. Hazard risks (HRs) were estimated from Cox proportion hazard regression. Among 14,262 participants (mean age, 38.8; 47.8% men), 5138 hypertension occurred (2687 men and 2451 women) occurred during a mean follow-up 9.6 years. Four body mass trajectory groups were identified as BMI loss, stable, moderate and substantial gain. Appropriately half of participants (48.0%) followed 1 of the 2 BMI gain trajectories, where BMI increased at least 3 kg/m2 overtime. Compared with participants with stable BMI, those gaining BMI substantially had higher risk of hypertension by 65% (HR 1.65, 95% CI 1.45-1.86) in male and 83% (HR 1.83, 95% CI 1.58-2.12) in female. The HRs in BMI loss patterns were 0.74 (0.62-0.89) in men and 0.87 (0.75-1.00) in women. Our findings imply that majority of Chinese adults transited up to a higher BMI level during follow-up. Avoiding excessive weight gain and maintaining stable weight might be important for hypertension prevention.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-92319-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=2045-2322&title=Scientific+Reports&atitle=Long-term+body+mass+trajectories+and+hypertension+by+sex+among+Chinese+adults%3A+a+24-year+open+cohort+study.&volume=11&issue=1&spage=12915&epage=&date=2021&doi=10.1038%2Fs41598-021-92319-4&pmid=34155269&sid=OVID:medline
+
+<650>
+Unique Identifier
+ 34946940
+Title
+ Developmental Effects of (Pre-)Gestational Diabetes on Offspring: Systematic Screening Using Omics Approaches. [Review]
+Source
+ Genes (Basel). 12(12), 2021 12 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shashikadze B; Flenkenthaler F; Stockl JB; Valla L; Renner S; Kemter E; Wolf E; Frohlich T
+Author NameID
+ Stockl, Jan B; ORCID: https://orcid.org/0000-0002-6432-1271
+ Kemter, Elisabeth; ORCID: https://orcid.org/0000-0001-7785-7502
+ Wolf, Eckhard; ORCID: https://orcid.org/0000-0002-0430-9510
+ Frohlich, Thomas; ORCID: https://orcid.org/0000-0002-4709-3211
+Authors Full Name
+ Shashikadze, Bachuki; Flenkenthaler, Florian; Stockl, Jan B; Valla, Libera; Renner, Simone; Kemter, Elisabeth; Wolf, Eckhard; Frohlich, Thomas.
+Institution
+ Shashikadze, Bachuki. Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany.
+ Flenkenthaler, Florian. Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany.
+ Stockl, Jan B. Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany.
+ Valla, Libera. Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.
+ Renner, Simone. Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.
+ Renner, Simone. Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleisheim, Germany.
+ Renner, Simone. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
+ Kemter, Elisabeth. Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.
+ Kemter, Elisabeth. Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleisheim, Germany.
+ Kemter, Elisabeth. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
+ Wolf, Eckhard. Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany.
+ Wolf, Eckhard. Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.
+ Wolf, Eckhard. Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleisheim, Germany.
+ Wolf, Eckhard. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
+ Frohlich, Thomas. Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Birth Weight
+ Body Mass Index
+ *Diabetes, Gestational/me [Metabolism]
+ Diabetes, Gestational/pp [Physiopathology]
+ Female
+ Humans
+ *Metabolic Diseases/et [Etiology]
+ Obesity
+ Pregnancy
+ Prenatal Exposure Delayed Effects/ep [Epidemiology]
+ *Prenatal Exposure Delayed Effects/pp [Physiopathology]
+ Risk Factors
+Keyword Heading
+ DOHaD (developmental origins of health and disease)
+ Omics
+ gestational diabetes mellitus (GDM)
+ pregestational diabetes mellitus (PGDM)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Worldwide, gestational diabetes affects 2-25% of pregnancies. Due to related disturbances of the maternal metabolism during the periconceptional period and pregnancy, children bear an increased risk for future diseases. It is well known that an aberrant intrauterine environment caused by elevated maternal glucose levels is related to elevated risks for increased birth weights and metabolic disorders in later life, such as obesity or type 2 diabetes. The complexity of disturbances induced by maternal diabetes, with multiple underlying mechanisms, makes early diagnosis or prevention a challenging task. Omics technologies allowing holistic quantification of several classes of molecules from biological fluids, cells, or tissues are powerful tools to systematically investigate the effects of maternal diabetes on the offspring in an unbiased manner. Differentially abundant molecules or distinct molecular profiles may serve as diagnostic biomarkers, which may also support the development of preventive and therapeutic strategies. In this review, we summarize key findings from state-of-the-art Omics studies addressing the impact of maternal diabetes on offspring health.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fgenes12121991
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shashikadze&issn=2073-4425&title=Genes+%28Basel%29&atitle=Developmental+Effects+of+%28Pre-%29Gestational+Diabetes+on+Offspring%3A+Systematic+Screening+Using+Omics+Approaches.&volume=12&issue=12&spage=&epage=&date=2021&doi=10.3390%2Fgenes12121991&pmid=34946940&sid=OVID:medline
+
+<651>
+Unique Identifier
+ 34485526
+Title
+ Reduced Insulin-Like Growth Factor 1 Is Associated with Insulin Resistance in Obese Prepubertal Boys.
+Source
+ BioMed Research International. 2021:6680316, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kuang J; Zhang L; Xu Y; Xue J; Liang S; Xiao J
+Author NameID
+ Liang, Shuang; ORCID: https://orcid.org/0000-0001-9067-6829
+Authors Full Name
+ Kuang, Jiangying; Zhang, Li; Xu, Yueqin; Xue, Jiang; Liang, Shuang; Xiao, Juan.
+Institution
+ Kuang, Jiangying. Department of Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, China.
+ Zhang, Li. Child Health Care Center, The First Affiliated Hospital of Shandong First Medical University, China.
+ Xu, Yueqin. Child Health Care Center, The First Affiliated Hospital of Shandong First Medical University, China.
+ Xue, Jiang. Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, China.
+ Liang, Shuang. Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, China.
+ Xiao, Juan. Center of Evidence-Based Medicine, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, China.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Child
+ Humans
+ Insulin/bl [Blood]
+ *Insulin/me [Metabolism]
+ *Insulin Resistance/ph [Physiology]
+ *Insulin-Like Growth Factor I/me [Metabolism]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/pa [Pathology]
+ *Obesity/bl [Blood]
+ *Puberty/bl [Blood]
+ Puberty/ph [Physiology]
+Abstract
+ As one of the most common features of obesity, insulin resistance is central to the pathogenesis of the metabolic syndrome. Low insulin-like growth factor 1 (IGF-1) levels have been proven to be associated with many traditional cardiovascular risk factors, but it still remains controversial with the relationship between IGF-1 and insulin resistance. Accordingly, the main purpose of this study is to investigate the relationship between IGF-1 and insulin resistance in obese prepubertal boys. We used the whole-body insulin sensitivity index (WBISI) to represent insulin resistance. 70 obese prepubertal boys were included in the study, and the obese subjects were divided into two groups by using 1.285 as a threshold value for WBISI. Clinical examination and laboratory examinations were assessed for all participants. Among obese boys, the group of children with WBISI <= 1.285 had lower IGF-1 standard deviation scores (SDS) (p = 0.021) than the WBISI > 1.285 group. The results of multiple linear analyses show that lg WBISI was positively correlated with IGF-1 SDS (p = 0.031) after adjusting for traditional cardiovascular risk factors. IGF-1 SDS was negatively associated with insulin resistance in obese prepubertal boys, independent of other traditional cardiovascular disease risk markers. Copyright © 2021 Jiangying Kuang et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IGF1 protein, human). 0 (Insulin). 67763-96-6 (Insulin-Like Growth Factor I).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f6680316
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kuang&issn=2314-6141&title=BioMed+Research+International&atitle=Reduced+Insulin-Like+Growth+Factor+1+Is+Associated+with+Insulin+Resistance+in+Obese+Prepubertal+Boys.&volume=2021&issue=&spage=6680316&epage=&date=2021&doi=10.1155%2F2021%2F6680316&pmid=34485526&sid=OVID:medline
+
+<652>
+Unique Identifier
+ 34314488
+Title
+ Blood biomarkers reflect the effects of obesity and inflammation on the human breast transcriptome.
+Source
+ Carcinogenesis. 42(10):1281-1292, 2021 10 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cho BA; Iyengar NM; Zhou XK; Morrow M; Giri DD; Verma A; Elemento O; Pollak M; Dannenberg AJ
+Author NameID
+ Dannenberg, Andrew J; ORCID: https://orcid.org/0000-0002-1901-6497
+Authors Full Name
+ Cho, Byuri Angela; Iyengar, Neil M; Zhou, Xi Kathy; Morrow, Monica; Giri, Dilip D; Verma, Akanksha; Elemento, Olivier; Pollak, Michael; Dannenberg, Andrew J.
+Institution
+ Cho, Byuri Angela. Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
+ Iyengar, Neil M. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
+ Zhou, Xi Kathy. Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA.
+ Morrow, Monica. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
+ Giri, Dilip D. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
+ Verma, Akanksha. Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.
+ Elemento, Olivier. Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.
+ Elemento, Olivier. Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA.
+ Pollak, Michael. Department of Medicine and Oncology, McGill University, Montreal, Quebec, Canada.
+ Dannenberg, Andrew J. Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
+MeSH Subject Headings
+ Adipose Tissue, White/pa [Pathology]
+ Biomarkers/bl [Blood]
+ Breast Neoplasms/bl [Blood]
+ Breast Neoplasms/co [Complications]
+ *Breast Neoplasms/ge [Genetics]
+ Female
+ Humans
+ *Inflammation/co [Complications]
+ *Obesity/co [Complications]
+ *Transcriptome
+Abstract
+ Obesity is a risk factor for the development of post-menopausal breast cancer. Breast white adipose tissue (WAT) inflammation, which is commonly found in women with excess body fat, is also associated with increased breast cancer risk. Both local and systemic effects are probably important for explaining the link between excess body fat, adipose inflammation and breast cancer. The first goal of this cross-sectional study of 196 women was to carry out transcriptome profiling to define the molecular changes that occur in the breast related to excess body fat and WAT inflammation. A second objective was to determine if commonly measured blood biomarkers of risk and prognosis reflect molecular changes in the breast. Breast WAT inflammation was assessed by immunohistochemistry. Bulk RNA-sequencing was carried out to assess gene expression in non-tumorous breast. Obesity and WAT inflammation were associated with a large number of differentially expressed genes and changes in multiple pathways linked to the development and progression of breast cancer. Altered pathways included inflammatory response, complement, KRAS signaling, tumor necrosis factor alpha signaling via NFkB, interleukin (IL)6-JAK-STAT3 signaling, epithelial mesenchymal transition, angiogenesis, interferon gamma response and transforming growth factor (TGF)-beta signaling. Increased expression of several drug targets such as aromatase, TGF-beta1, IDO-1 and PD-1 were observed. Levels of various blood biomarkers including high sensitivity C-reactive protein, IL6, leptin, adiponectin, triglycerides, high-density lipoprotein cholesterol and insulin were altered and correlated with molecular changes in the breast. Collectively, this study helps to explain both the link between obesity and breast cancer and the utility of blood biomarkers for determining risk and prognosis. Copyright © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1093%2fcarcin%2fbgab066
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cho&issn=0143-3334&title=Carcinogenesis&atitle=Blood+biomarkers+reflect+the+effects+of+obesity+and+inflammation+on+the+human+breast+transcriptome.&volume=42&issue=10&spage=1281&epage=1292&date=2021&doi=10.1093%2Fcarcin%2Fbgab066&pmid=34314488&sid=OVID:medline
+
+<653>
+Unique Identifier
+ 34192895
+Title
+ Aflibercept, a VEGF (Vascular Endothelial Growth Factor)-Trap, Reduces Vascular Permeability and Stroke-Induced Brain Swelling in Obese Mice.
+Source
+ Stroke. 52(8):2637-2648, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim ID; Cave JW; Cho S
+Authors Full Name
+ Kim, Il-Doo; Cave, John W; Cho, Sunghee.
+Institution
+ Kim, Il-Doo. Burke Neurological Institute, White Plains, NY (I.-d.K., S.C.).
+ Cave, John W. InVitro Cell Research, Englewood, NJ (J.W.C.).
+ Cho, Sunghee. Burke Neurological Institute, White Plains, NY (I.-d.K., S.C.).
+ Cho, Sunghee. Feil Brain Mind Research Institute, Weill Cornell Medicine, New York, NY (S.C.).
+MeSH Subject Headings
+ Angiogenesis Inhibitors/pd [Pharmacology]
+ Angiogenesis Inhibitors/tu [Therapeutic Use]
+ Animals
+ Biomarkers/me [Metabolism]
+ Blood-Brain Barrier/de [Drug Effects]
+ Blood-Brain Barrier/me [Metabolism]
+ *Brain Edema/dt [Drug Therapy]
+ Brain Edema/me [Metabolism]
+ *Capillary Permeability/de [Drug Effects]
+ Capillary Permeability/ph [Physiology]
+ Diet, High-Fat/ae [Adverse Effects]
+ Female
+ Male
+ Mice
+ Mice, Inbred C57BL
+ *Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Receptors, Vascular Endothelial Growth Factor/tu [Therapeutic Use]
+ Recombinant Fusion Proteins/pd [Pharmacology]
+ *Recombinant Fusion Proteins/tu [Therapeutic Use]
+ *Stroke/dt [Drug Therapy]
+ Stroke/me [Metabolism]
+ *Vascular Endothelial Growth Factor A/bi [Biosynthesis]
+Keyword Heading
+ brain edema
+ comorbidity
+ obesity
+ stroke
+ vascular endothelial growth factor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background and Purpose: Brain edema is an important underlying pathology in acute stroke, especially when comorbidities are present. VEGF (Vascular endothelial growth factor) signaling is implicated in edema. This study investigated whether obesity impacts VEGF signaling and brain edema, as well as whether VEGF inhibition alters stroke outcome in obese subjects.
+
+ Methods: High-fat diet-induced obese mice were subjected to a transient middle cerebral artery occlusion. VEGF-A and VEGFR2 (receptor) expression, infarct volume, and swelling were measured 3 days post-middle cerebral artery occlusion. To validate the effect of an anti-VEGF strategy, we used aflibercept, a fusion protein that has a VEGF-binding domain and acts as a decoy receptor, in human umbilical vein endothelial cells stimulated with rVEGF (recombinant VEGF; 50 ng/mL) for permeability and tube formation. In vivo, aflibercept (10 mg/kg) or IgG control was administered in obese mice 3 hours after transient 30 minutes middle cerebral artery occlusion. Blood-brain barrier integrity was assessed by IgG staining and dextran extravasation in the postischemic brain. A separate cohort of nonobese (lean) mice was subjected to 40 minutes middle cerebral artery occlusion to test the effect of aflibercept on malignant infarction.
+
+ Results: Compared with lean mice, obese mice had increased mortality, infarct volume, swelling, and blood-brain barrier disruption. These outcomes were also associated with increased VEGF-A and VEGFR2 expression. Aflibercept reduced VEGF-A-stimulated permeability and tube formation in human umbilical vein endothelial cells. Compared with the IgG-treated controls, mice treated with aflibercept had reduced mortality rates (40% versus 17%), hemorrhagic transformation (43% versus 27%), and brain swelling (28% versus 18%), although the infarct size was similar. In nonobese mice with large stroke, aflibercept neither improved nor exacerbated stroke outcomes.
+
+ Conclusions: The study demonstrates that aflibercept selectively attenuates stroke-induced brain edema and vascular permeability in obese mice. These findings suggest the repurposing of aflibercept to reduce obesity-enhanced brain edema in acute stroke.
+Registry Number/Name of Substance
+ 0 (Angiogenesis Inhibitors). 0 (Biomarkers). 0 (Recombinant Fusion Proteins). 0 (Vascular Endothelial Growth Factor A). 0 (vascular endothelial growth factor A, mouse). 15C2VL427D (aflibercept). EC 2-7-10-1 (Receptors, Vascular Endothelial Growth Factor).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1161%2fSTROKEAHA.121.034362
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=0039-2499&title=Stroke&atitle=Aflibercept%2C+a+VEGF+%28Vascular+Endothelial+Growth+Factor%29-Trap%2C+Reduces+Vascular+Permeability+and+Stroke-Induced+Brain+Swelling+in+Obese+Mice.&volume=52&issue=8&spage=2637&epage=2648&date=2021&doi=10.1161%2FSTROKEAHA.121.034362&pmid=34192895&sid=OVID:medline
+
+<654>
+Unique Identifier
+ 34135578
+Title
+ Metabolic Syndrome in an Aging Society - Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis.
+Source
+ Clinical Interventions In Aging. 16:1057-1070, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dziegielewska-Gesiak S
+Author NameID
+ Dziegielewska-Gesiak, Sylwia; ORCID: https://orcid.org/0000-0003-1019-5959
+Authors Full Name
+ Dziegielewska-Gesiak, Sylwia.
+Institution
+ Dziegielewska-Gesiak, Sylwia. Department of Internal Medicine, Medical University of Silesia in Katowice, Bytom, Poland.
+MeSH Subject Headings
+ Aged
+ Aging/ph [Physiology]
+ *Antioxidants/me [Metabolism]
+ *Atherosclerosis/me [Metabolism]
+ Atherosclerosis/pp [Physiopathology]
+ Biomarkers/me [Metabolism]
+ Humans
+ *Inflammation/me [Metabolism]
+ Inflammation/pp [Physiopathology]
+ Lipid Metabolism
+ Male
+ *Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/me [Metabolism]
+ *Oxidants/me [Metabolism]
+ Oxidative Stress/ph [Physiology]
+Keyword Heading
+ aging
+ atherosclerosis
+ inflammation
+ metabolic syndrome
+ oxidant-antioxidant balance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: The prevalence of metabolic syndrome among the elderly population is growing. The elements of metabolic syndrome in an aging society are currently being researched. Atherosclerosis is a slow process in which the first symptoms may be observed after many years. The mechanisms underlying the progression of atherosclerosis are oxidative stress and inflammation. Inflammation and oxidative stress are associated with the increased incidence of metabolic syndrome. Taking the above into consideration, metabolic syndrome is thought to be a clinical equivalent of atherosclerosis.
+
+ AIM: The aim of this paper is to review the impact of the interplay of oxidant-antioxidant and inflammation markers in metabolic syndrome in general as well as its components in the pathophysiology which underlies development of atherosclerosis in elderly individuals.
+
+ METHODS: A systematic scan of online resources designed for elderly (>=65 years) published from 2005 to the end of 2020 were reviewed. This was supplemented with grey literature and then all resources were narratively analyzed. The analysis included the following terms: "atherosclerosis or metabolic syndrome" and "oxidative stress or inflammation" and "elderly" to find reports of atherosclerotic disease from asymptomatic to life-threatening among the elderly population with metabolic syndrome .
+
+ RESULTS: The work summarizes articles that were applicable to this study, including systematic reviews, qualitative studies and opinion pieces. Current knowledge focuses on monitoring the inflammation and oxidant-antioxidant imbalance in disentangling atherosclerosis in patients diagnosed with metabolic syndrome. The population-based studies described inflammation, increased oxidative stress and weak antioxidant defense systems as the mechanisms underlying atherosclerosis development. Moreover, there are discussions that these targets could potentially be a point of intervention to reduce the development of atherosclerosis in the elderly, especially those with altered glucose and lipid metabolism. Specific markers may be used as an approach for the prevention and lifestyle modification of atherosclerotic disease in such population.
+
+ CONCLUSION: Metabolic syndrome and its components are important contributors in the progression of atherosclerotic disease in the elderly population but constant efforts should be made to broaden our knowledge of elderly groups who are the most susceptible for the development of atherosclerosis complications. Copyright © 2021 Dziegielewska-Gesiak.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Oxidants).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.2147%2fCIA.S306982
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dziegielewska-Gesiak&issn=1176-9092&title=Clinical+Interventions+In+Aging&atitle=Metabolic+Syndrome+in+an+Aging+Society+-+Role+of+Oxidant-Antioxidant+Imbalance+and+Inflammation+Markers+in+Disentangling+Atherosclerosis.&volume=16&issue=&spage=1057&epage=1070&date=2021&doi=10.2147%2FCIA.S306982&pmid=34135578&sid=OVID:medline
+
+<655>
+Unique Identifier
+ 33947088
+Title
+ Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats.
+Source
+ Molecules. 26(9), 2021 Apr 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Martiniakova M; Blahova J; Kovacova V; Babikova M; Mondockova V; Kalafova A; Capcarova M; Omelka R
+Author NameID
+ Martiniakova, Monika; ORCID: https://orcid.org/0000-0003-1889-026X
+ Mondockova, Vladimira; ORCID: https://orcid.org/0000-0002-7186-4282
+ Omelka, Radoslav; ORCID: https://orcid.org/0000-0002-6493-9880
+Authors Full Name
+ Martiniakova, Monika; Blahova, Jana; Kovacova, Veronika; Babikova, Martina; Mondockova, Vladimira; Kalafova, Anna; Capcarova, Marcela; Omelka, Radoslav.
+Institution
+ Martiniakova, Monika. Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
+ Blahova, Jana. Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
+ Kovacova, Veronika. Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
+ Babikova, Martina. Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
+ Mondockova, Vladimira. Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
+ Kalafova, Anna. Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.
+ Capcarova, Marcela. Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.
+ Omelka, Radoslav. Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
+MeSH Subject Headings
+ *Animal Feed
+ Animals
+ Biomarkers
+ Bone and Bones/dg [Diagnostic Imaging]
+ *Bone and Bones/me [Metabolism]
+ *Bone and Bones/pa [Pathology]
+ Diabetes Mellitus, Experimental
+ Disease Models, Animal
+ *Lipids/bl [Blood]
+ Male
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ *Propolis/ad [Administration & Dosage]
+ Rats
+ Rats, Zucker
+ X-Ray Microtomography
+Keyword Heading
+ ZDF rat
+ bee bread
+ bone morphology
+ diabetes mellitus
+ functional food
+ lipid profile
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study examined for the first time whether bee bread (BB, consisting of monofloral rape bee pollen) could alleviate lipid derangements and reduced bone quality in Zucker diabetic fatty (ZDF) rats, which are considered an appropriate animal model for type 2 diabetes mellitus (T2DM) investigation. Adult ZDF rats were segregated into four groups: lean non-diabetic rats (L group), obese diabetic rats untreated (C group), and those treated with the BB at two doses (500 and 700 mg/kg body weight, respectively, B1 and B2 groups) for 10 weeks. Significantly reduced levels of total cholesterol and triglyceride were recorded in the B2 group versus the C group. In both BB-treated groups, significantly increased relative volume of trabecular bone and trabecular thickness, enhanced density of secondary osteons, accelerated periosteal bone apposition, and improved blood flow were observed. A positive effect of higher dose of BB on femoral weight and cortical bone thickness was also demonstrated. Our results suggest a promising potential of BB to ameliorate T2DM-related complications associated with lipid and bone damages.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 9009-62-5 (Propolis).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fmolecules26092616
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Martiniakova&issn=1420-3049&title=Molecules&atitle=Bee+Bread+Can+Alleviate+Lipid+Abnormalities+and+Impaired+Bone+Morphology+in+Obese+Zucker+Diabetic+Rats.&volume=26&issue=9&spage=&epage=&date=2021&doi=10.3390%2Fmolecules26092616&pmid=33947088&sid=OVID:medline
+
+<656>
+Unique Identifier
+ 34543281
+Title
+ The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium.
+Source
+ PLoS Medicine / Public Library of Science. 18(9):e1003786, 2021 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Guida F; Tan VY; Corbin LJ; Smith-Byrne K; Alcala K; Langenberg C; Stewart ID; Butterworth AS; Surendran P; Achaintre D; Adamski J; Amiano P; Bergmann MM; Bull CJ; Dahm CC; Gicquiau A; Giles GG; Gunter MJ; Haller T; Langhammer A; Larose TL; Ljungberg B; Metspalu A; Milne RL; Muller DC; Nost TH; Pettersen Sorgjerd E; Prehn C; Riboli E; Rinaldi S; Rothwell JA; Scalbert A; Schmidt JA; Severi G; Sieri S; Vermeulen R; Vincent EE; Waldenberger M; Timpson NJ; Johansson M
+Author NameID
+ Guida, Florence; ORCID: https://orcid.org/0000-0002-9652-2430
+ Tan, Vanessa Y; ORCID: https://orcid.org/0000-0001-7938-127X
+ Corbin, Laura J; ORCID: https://orcid.org/0000-0002-4032-9500
+ Alcala, Karine; ORCID: https://orcid.org/0000-0003-2308-9880
+ Langenberg, Claudia; ORCID: https://orcid.org/0000-0002-5017-7344
+ Adamski, Jerzy; ORCID: https://orcid.org/0000-0001-9259-0199
+ Bull, Caroline J; ORCID: https://orcid.org/0000-0002-2176-5120
+ Dahm, Christina C; ORCID: https://orcid.org/0000-0003-0481-2893
+ Giles, Graham G; ORCID: https://orcid.org/0000-0003-4946-9099
+ Langhammer, Arnulf; ORCID: https://orcid.org/0000-0001-5296-6673
+ Ljungberg, Borje; ORCID: https://orcid.org/0000-0002-4121-3753
+ Milne, Roger L; ORCID: https://orcid.org/0000-0001-5764-7268
+ Nost, Therese H; ORCID: https://orcid.org/0000-0001-6805-3094
+ Pettersen Sorgjerd, Elin; ORCID: https://orcid.org/0000-0002-5995-2386
+ Prehn, Cornelia; ORCID: https://orcid.org/0000-0002-1274-4715
+ Riboli, Elio; ORCID: https://orcid.org/0000-0001-6795-6080
+ Rothwell, Joseph A; ORCID: https://orcid.org/0000-0002-6927-3360
+ Scalbert, Augustin; ORCID: https://orcid.org/0000-0001-6651-6710
+ Schmidt, Julie A; ORCID: https://orcid.org/0000-0002-7733-8750
+ Severi, Gianluca; ORCID: https://orcid.org/0000-0001-7157-419X
+ Sieri, Sabina; ORCID: https://orcid.org/0000-0001-5201-172X
+ Vincent, Emma E; ORCID: https://orcid.org/0000-0002-8917-7384
+ Timpson, Nicholas J; ORCID: https://orcid.org/0000-0002-7141-9189
+ Johansson, Mattias; ORCID: https://orcid.org/0000-0002-3116-5081
+Authors Full Name
+ Guida, Florence; Tan, Vanessa Y; Corbin, Laura J; Smith-Byrne, Karl; Alcala, Karine; Langenberg, Claudia; Stewart, Isobel D; Butterworth, Adam S; Surendran, Praveen; Achaintre, David; Adamski, Jerzy; Amiano, Pilar; Bergmann, Manuela M; Bull, Caroline J; Dahm, Christina C; Gicquiau, Audrey; Giles, Graham G; Gunter, Marc J; Haller, Toomas; Langhammer, Arnulf; Larose, Tricia L; Ljungberg, Borje; Metspalu, Andres; Milne, Roger L; Muller, David C; Nost, Therese H; Pettersen Sorgjerd, Elin; Prehn, Cornelia; Riboli, Elio; Rinaldi, Sabina; Rothwell, Joseph A; Scalbert, Augustin; Schmidt, Julie A; Severi, Gianluca; Sieri, Sabina; Vermeulen, Roel; Vincent, Emma E; Waldenberger, Melanie; Timpson, Nicholas J; Johansson, Mattias.
+Institution
+ Guida, Florence. Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Tan, Vanessa Y. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
+ Tan, Vanessa Y. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
+ Corbin, Laura J. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
+ Corbin, Laura J. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
+ Smith-Byrne, Karl. Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Alcala, Karine. Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Langenberg, Claudia. MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
+ Stewart, Isobel D. MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
+ Butterworth, Adam S. British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
+ Butterworth, Adam S. British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom.
+ Butterworth, Adam S. Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.
+ Butterworth, Adam S. National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.
+ Surendran, Praveen. British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
+ Surendran, Praveen. British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom.
+ Surendran, Praveen. Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.
+ Surendran, Praveen. Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
+ Achaintre, David. Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Adamski, Jerzy. Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Adamski, Jerzy. Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
+ Adamski, Jerzy. Chair of Experimental Genetics, School of Life Science, Weihenstephan, Technische Universitat Munchen, Freising, Germany.
+ Adamski, Jerzy. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
+ Amiano, Pilar. Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.
+ Amiano, Pilar. Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastian, Spain.
+ Amiano, Pilar. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
+ Bergmann, Manuela M. German Institute of Human Nutrition Potsdam-Rehbrucke, Nuthetal, Germany.
+ Bull, Caroline J. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
+ Bull, Caroline J. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
+ Bull, Caroline J. School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
+ Bull, Caroline J. Bristol Renal, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
+ Dahm, Christina C. Department of Public Health, Aarhus University, Aarhus, Denmark.
+ Gicquiau, Audrey. Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Giles, Graham G. Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
+ Giles, Graham G. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
+ Giles, Graham G. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.
+ Gunter, Marc J. Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Haller, Toomas. Institute of Genomics, University of Tartu, Tartu, Estonia.
+ Langhammer, Arnulf. HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
+ Langhammer, Arnulf. Levanger Hospital, Nord-Trondelag Hospital Trust, Levanger, Norway.
+ Larose, Tricia L. Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Larose, Tricia L. HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
+ Larose, Tricia L. Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway.
+ Ljungberg, Borje. Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden.
+ Metspalu, Andres. Institute of Genomics, University of Tartu, Tartu, Estonia.
+ Milne, Roger L. Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
+ Milne, Roger L. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
+ Milne, Roger L. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.
+ Muller, David C. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
+ Nost, Therese H. Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromso, Norway.
+ Pettersen Sorgjerd, Elin. HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
+ Prehn, Cornelia. Metabolomics and Proteomics Core (MPC), Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Riboli, Elio. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
+ Rinaldi, Sabina. Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Rothwell, Joseph A. Universite Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Equipe "Exposome et Heredite", CESP UMR1018, Inserm, Villejuif, France.
+ Scalbert, Augustin. Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+ Schmidt, Julie A. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Severi, Gianluca. Universite Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Equipe "Exposome et Heredite", CESP UMR1018, Inserm, Villejuif, France.
+ Severi, Gianluca. Department of Statistics, Computer Science and Applications (DISIA), University of Florence, Florence, Italy.
+ Sieri, Sabina. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.
+ Vermeulen, Roel. Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands.
+ Vincent, Emma E. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
+ Vincent, Emma E. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
+ Vincent, Emma E. School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
+ Vincent, Emma E. Bristol Renal, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
+ Waldenberger, Melanie. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
+ Timpson, Nicholas J. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
+ Timpson, Nicholas J. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
+ Johansson, Mattias. Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Case-Control Studies
+ Europe/ep [Epidemiology]
+ Female
+ Humans
+ Incidence
+ *Kidney Neoplasms/bl [Blood]
+ Kidney Neoplasms/di [Diagnosis]
+ Kidney Neoplasms/ep [Epidemiology]
+ Kidney Neoplasms/ge [Genetics]
+ Male
+ Mendelian Randomization Analysis
+ *Metabolome
+ Metabolomics
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Victoria/ep [Epidemiology]
+Abstract
+ BACKGROUND: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulating metabolites that predispose kidney cancer and to evaluate the extent to which they are influenced by body mass index (BMI).
+
+ METHODS AND FINDINGS: We assessed the association between circulating levels of 1,416 metabolites and incident kidney cancer using pre-diagnostic blood samples from up to 1,305 kidney cancer case-control pairs from 5 prospective cohort studies. Cases were diagnosed on average 8 years after blood collection. We found 25 metabolites robustly associated with kidney cancer risk. In particular, 14 glycerophospholipids (GPLs) were inversely associated with risk, including 8 phosphatidylcholines (PCs) and 2 plasmalogens. The PC with the strongest association was PC ae C34:3 with an odds ratio (OR) for 1 standard deviation (SD) increment of 0.75 (95% confidence interval [CI]: 0.68 to 0.83, p = 2.6 x 10-8). In contrast, 4 amino acids, including glutamate (OR for 1 SD = 1.39, 95% CI: 1.20 to 1.60, p = 1.6 x 10-5), were positively associated with risk. Adjusting for BMI partly attenuated the risk association for some-but not all-metabolites, whereas other known risk factors of kidney cancer, such as smoking and alcohol consumption, had minimal impact on the observed associations. A mendelian randomisation (MR) analysis of the influence of BMI on the blood metabolome highlighted that some metabolites associated with kidney cancer risk are influenced by BMI. Specifically, elevated BMI appeared to decrease levels of several GPLs that were also found inversely associated with kidney cancer risk (e.g., -0.17 SD change [sBMI] in 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2) levels per SD change in BMI, p = 3.4 x 10-5). BMI was also associated with increased levels of glutamate (sBMI: 0.12, p = 1.5 x 10-3). While our results were robust across the participating studies, they were limited to study participants of European descent, and it will, therefore, be important to evaluate if our findings can be generalised to populations with different genetic backgrounds.
+
+ CONCLUSIONS: This study suggests a potentially important role of the blood metabolome in kidney cancer aetiology by highlighting a wide range of metabolites associated with the risk of developing kidney cancer and the extent to which changes in levels of these metabolites are driven by BMI-the principal modifiable risk factor of kidney cancer.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study. Observational Study. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1371%2fjournal.pmed.1003786
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Guida&issn=1549-1277&title=PLoS+Medicine+%2F+Public+Library+of+Science&atitle=The+blood+metabolome+of+incident+kidney+cancer%3A+A+case-control+study+nested+within+the+MetKid+consortium.&volume=18&issue=9&spage=e1003786&epage=&date=2021&doi=10.1371%2Fjournal.pmed.1003786&pmid=34543281&sid=OVID:medline
+
+<657>
+Unique Identifier
+ 34937562
+Title
+ Diet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke.
+Source
+ Cardiovascular Diabetology. 20(1):240, 2021 12 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karampatsi D; Zabala A; Wilhelmsson U; Dekens D; Vercalsteren E; Larsson M; Nystrom T; Pekny M; Patrone C; Darsalia V
+Author NameID
+ Patrone, Cesare; ORCID: http://orcid.org/0000-0003-0470-4606
+ Darsalia, Vladimer; ORCID: http://orcid.org/0000-0002-6693-934X
+Authors Full Name
+ Karampatsi, Dimitra; Zabala, Alexander; Wilhelmsson, Ulrika; Dekens, Doortje; Vercalsteren, Ellen; Larsson, Martin; Nystrom, Thomas; Pekny, Milos; Patrone, Cesare; Darsalia, Vladimer.
+Institution
+ Karampatsi, Dimitra. NeuroCardioMetabol Group, Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, 118 83, Stockholm, Sweden.
+ Zabala, Alexander. NeuroCardioMetabol Group, Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, 118 83, Stockholm, Sweden.
+ Wilhelmsson, Ulrika. Laboratory of Astrocyte Biology and CNS Regeneration, Department of Clinical Neuroscience and Rehabilitation, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
+ Dekens, Doortje. NeuroCardioMetabol Group, Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, 118 83, Stockholm, Sweden.
+ Vercalsteren, Ellen. NeuroCardioMetabol Group, Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, 118 83, Stockholm, Sweden.
+ Larsson, Martin. NeuroCardioMetabol Group, Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, 118 83, Stockholm, Sweden.
+ Nystrom, Thomas. NeuroCardioMetabol Group, Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, 118 83, Stockholm, Sweden.
+ Pekny, Milos. Laboratory of Astrocyte Biology and CNS Regeneration, Department of Clinical Neuroscience and Rehabilitation, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
+ Patrone, Cesare. NeuroCardioMetabol Group, Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, 118 83, Stockholm, Sweden. cesare.patrone@ki.se.
+ Darsalia, Vladimer. NeuroCardioMetabol Group, Department of Clinical Science and Education, Sodersjukhuset, Internal Medicine, Karolinska Institutet, 118 83, Stockholm, Sweden. vladimer.darsalia@ki.se.
+MeSH Subject Headings
+ Animals
+ Behavior, Animal
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Brain/me [Metabolism]
+ Brain/pa [Pathology]
+ *Brain/pp [Physiopathology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/dh [Diet Therapy]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Diet, High-Fat
+ Disease Models, Animal
+ Glycemic Control
+ Infarction, Middle Cerebral Artery/bl [Blood]
+ *Infarction, Middle Cerebral Artery/dh [Diet Therapy]
+ Infarction, Middle Cerebral Artery/pa [Pathology]
+ Infarction, Middle Cerebral Artery/pp [Physiopathology]
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Recovery of Function
+ Stroke/bl [Blood]
+ *Stroke/dh [Diet Therapy]
+ Stroke/pa [Pathology]
+ Stroke/pp [Physiopathology]
+ Time Factors
+ *Weight Loss
+ Mice
+Keyword Heading
+ Insulin resistance
+ Neurological recovery
+ Stroke
+ Type 2 diabetes
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Post-stroke functional recovery is severely impaired by type 2 diabetes (T2D). This is an important clinical problem since T2D is one of the most common diseases. Because weight loss-based strategies have been shown to decrease stroke risk in people with T2D, we aimed to investigate whether diet-induced weight loss can also improve post-stroke functional recovery and identify some of the underlying mechanisms.
+
+ METHODS: T2D/obesity was induced by 6 months of high-fat diet (HFD). Weight loss was achieved by a short- or long-term dietary change, replacing HFD with standard diet for 2 or 4 months, respectively. Stroke was induced by middle cerebral artery occlusion and post-stroke recovery was assessed by sensorimotor tests. Mechanisms involved in neurovascular damage in the post-stroke recovery phase, i.e. neuroinflammation, impaired angiogenesis and cellular atrophy of GABAergic parvalbumin (PV)+ interneurons were assessed by immunohistochemistry/quantitative microscopy.
+
+ RESULTS: Both short- and long-term dietary change led to similar weight loss. However, only the latter enhanced functional recovery after stroke. This effect was associated with pre-stroke normalization of fasting glucose and insulin resistance, and with the reduction of T2D-induced cellular atrophy of PV+ interneurons. Moreover, stroke recovery was associated with decreased T2D-induced neuroinflammation and reduced astrocyte reactivity in the contralateral striatum.
+
+ CONCLUSION: The global diabetes epidemic will dramatically increase the number of people in need of post-stroke treatment and care. Our results suggest that diet-induced weight loss leading to pre-stroke normalization of glucose metabolism has great potential to reduce the sequelae of stroke in the diabetic population. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12933-021-01426-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karampatsi&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Diet-induced+weight+loss+in+obese%2Fdiabetic+mice+normalizes+glucose+metabolism+and+promotes+functional+recovery+after+stroke.&volume=20&issue=1&spage=240&epage=&date=2021&doi=10.1186%2Fs12933-021-01426-z&pmid=34937562&sid=OVID:medline
+
+<658>
+Unique Identifier
+ 34835957
+Title
+ Sex Differences in Early Programming by Maternal High Fat Diet Induced-Obesity and Fish Oil Supplementation in Mice.
+Source
+ Nutrients. 13(11), 2021 Oct 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ramalingam L; Menikdiwela KR; Spainhour S; Eboh T; Moustaid-Moussa N
+Author NameID
+ Ramalingam, Latha; ORCID: https://orcid.org/0000-0002-4856-7327
+ Moustaid-Moussa, Naima; ORCID: https://orcid.org/0000-0002-7508-8030
+Authors Full Name
+ Ramalingam, Latha; Menikdiwela, Kalhara R; Spainhour, Stephani; Eboh, Tochi; Moustaid-Moussa, Naima.
+Institution
+ Ramalingam, Latha. Department of Nutritional Sciences and Obesity Research Institute, Texas Tech University, Lubbock, TX 74909, USA.
+ Ramalingam, Latha. Department of Nutrition and Food Studies, Syracuse University, Syracuse, NY 13244, USA.
+ Menikdiwela, Kalhara R. Department of Nutritional Sciences and Obesity Research Institute, Texas Tech University, Lubbock, TX 74909, USA.
+ Spainhour, Stephani. Department of Nutritional Sciences and Obesity Research Institute, Texas Tech University, Lubbock, TX 74909, USA.
+ Eboh, Tochi. Department of Nutritional Sciences and Obesity Research Institute, Texas Tech University, Lubbock, TX 74909, USA.
+ Moustaid-Moussa, Naima. Department of Nutritional Sciences and Obesity Research Institute, Texas Tech University, Lubbock, TX 74909, USA.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ Adipose Tissue/me [Metabolism]
+ Adiposity/de [Drug Effects]
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ *Diet, High-Fat
+ *Dietary Supplements
+ Fatty Acids, Omega-3/me [Metabolism]
+ Female
+ *Fish Oils/pd [Pharmacology]
+ Glucose/me [Metabolism]
+ Inflammation/bl [Blood]
+ Lipid Metabolism/de [Drug Effects]
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ *Obesity/pa [Pathology]
+ Pregnancy
+ *Sex Characteristics
+ Triglycerides/me [Metabolism]
+ Mice
+Keyword Heading
+ fish oil
+ high fat diet
+ maternal obesity
+ mice
+ sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pre-pregnancy obesity is a contributing factor for impairments in offspring metabolic health. Interventional strategies during pregnancy are a potential approach to alleviate and/or prevent obesity and obesity related metabolic alterations in the offspring. Fish oil (FO), rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) exerts metabolic health benefits. However, the role of FO in early life remains still unknown. Hence, this study objective was to determine the effect of FO supplementation in mice from pre-pregnancy through lactation, and to study the post-natal metabolic health effects in gonadal fat and liver of offspring fed high fat (HF) diet with or without FO. Female C57BL6J mice aged 4-5 weeks were fed a HF (45% fat) diet supplemented with or without FO (30 g/kg of diet) and low fat (LF; 10% fat) pre-pregnancy through lactation. After weaning, offspring (male and female) from HF or FO dams either continued the same diet (HF-HF and FO-FO) or switched to the other diet (HF-FO and FO-HF) for 13 weeks, creating four groups of treatment, and LF-LF was used as a control group. Serum, gonadal fat and liver tissue were collected at termination for metabolic analyses. Offspring of both sexes fed HF with or without fish oil gained (p < 0.05) more weight post weaning, compared to LF-LF-fed mice. All the female offspring groups supplemented with FO had reduced body weight compared to the respective male groups. Further, FO-FO supplementation in both sexes (p < 0.05) improved glucose clearance and insulin sensitivity compared to HF-HF. All FO-FO fed mice had significantly reduced adipocyte size compared to HF-HF group in both male and females. Inflammation, measured by mRNA levels of monocyte chemoattractant protein 1 (Mcp1), was reduced (p < 0.05) with FO supplementation in both sexes in gonadal fat and in the liver. Markers of fatty acid synthesis, fatty acid synthase (Fasn) showed no sex specific differences in gonadal fat and liver of mice supplemented with HF. Female mice had lower liver triglycerides than male counterparts. Supplementation of FO in mice improved metabolic health of offspring by lowering markers of lipid synthesis and inflammation.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Fatty Acids, Omega-3). 0 (Fish Oils). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13113703
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ramalingam&issn=2072-6643&title=Nutrients&atitle=Sex+Differences+in+Early+Programming+by+Maternal+High+Fat+Diet+Induced-Obesity+and+Fish+Oil+Supplementation+in+Mice.&volume=13&issue=11&spage=&epage=&date=2021&doi=10.3390%2Fnu13113703&pmid=34835957&sid=OVID:medline
+
+<659>
+Unique Identifier
+ 34684532
+Title
+ Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats.
+Source
+ Nutrients. 13(10), 2021 Oct 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Groussard C; Plissonneau C; Josset L; Capel F; Mura M; Gouraud E; Mairesse G; Chesneau G; Barnich N; Pialoux V; Boisseau N
+Author NameID
+ Groussard, Carole; ORCID: https://orcid.org/0000-0001-9819-7291
+ Plissonneau, Claire; ORCID: https://orcid.org/0000-0002-0169-9533
+ Capel, Frederic; ORCID: https://orcid.org/0000-0002-0133-0277
+ Mura, Mathilde; ORCID: https://orcid.org/0000-0003-3010-1788
+ Barnich, Nicolas; ORCID: https://orcid.org/0000-0001-9465-7844
+ Boisseau, Nathalie; ORCID: https://orcid.org/0000-0003-2835-1163
+Authors Full Name
+ Groussard, Carole; Plissonneau, Claire; Josset, Laurie; Capel, Frederic; Mura, Mathilde; Gouraud, Etienne; Mairesse, Guillaume; Chesneau, Guillaume; Barnich, Nicolas; Pialoux, Vincent; Boisseau, Nathalie.
+Institution
+ Groussard, Carole. Laboratoire M2S-EA7470, Univ-Rennes, F-35000 Rennes, France.
+ Plissonneau, Claire. Laboratoire des Adaptations Metaboliques a l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), CRNH Auvergne, Universite Clermont Auvergne, F-63000 Clermont-Ferrand, France.
+ Plissonneau, Claire. CRNH Auvergne, Microbes, Intestin, Inflammation et Susceptibilite de l'Hote (M2iSH), USC-INRAE 2018, UMR 1071 Inserm/Universite d'Auvergne, Universite Clermont Auvergne, F-63000 Clermont-Ferrand, France.
+ Josset, Laurie. Team "Atherosclerosis, Thrombosis and Physical Activity", Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM)-EA 7424, Universite Lyon 1, F-69100 Lyon, France.
+ Capel, Frederic. Unite de Nutrition Humaine (UNH), CRNH Auvergne, Universite Clermont Auvergne, INRAE, F-63000 Clermont-Ferrand, France.
+ Mura, Mathilde. Team "Atherosclerosis, Thrombosis and Physical Activity", Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM)-EA 7424, Universite Lyon 1, F-69100 Lyon, France.
+ Gouraud, Etienne. Team "Atherosclerosis, Thrombosis and Physical Activity", Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM)-EA 7424, Universite Lyon 1, F-69100 Lyon, France.
+ Mairesse, Guillaume. Valorex, La Messayais, F-35210 Combourtille, France.
+ Chesneau, Guillaume. Valorex, La Messayais, F-35210 Combourtille, France.
+ Barnich, Nicolas. CRNH Auvergne, Microbes, Intestin, Inflammation et Susceptibilite de l'Hote (M2iSH), USC-INRAE 2018, UMR 1071 Inserm/Universite d'Auvergne, Universite Clermont Auvergne, F-63000 Clermont-Ferrand, France.
+ Pialoux, Vincent. Team "Atherosclerosis, Thrombosis and Physical Activity", Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM)-EA 7424, Universite Lyon 1, F-69100 Lyon, France.
+ Pialoux, Vincent. Institut Universitaire de France, F-75231 Paris, France.
+ Boisseau, Nathalie. Laboratoire des Adaptations Metaboliques a l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), CRNH Auvergne, Universite Clermont Auvergne, F-63000 Clermont-Ferrand, France.
+MeSH Subject Headings
+ Animals
+ Antioxidants/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Catalase/me [Metabolism]
+ *Dietary Supplements
+ Feeding Behavior/de [Drug Effects]
+ *Feeding Behavior
+ *High-Intensity Interval Training
+ *Linseed Oil/pd [Pharmacology]
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Male
+ Nitrates/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/pa [Pathology]
+ Oxidative Stress/de [Drug Effects]
+ *Oxidative Stress
+ Rats, Wistar
+ Subcutaneous Tissue/de [Drug Effects]
+ Subcutaneous Tissue/me [Metabolism]
+ Superoxide Dismutase/me [Metabolism]
+ Up-Regulation/de [Drug Effects]
+ Rats
+Keyword Heading
+ high fat diet
+ high intensity interval training
+ linseed oil supplementation
+ obesity
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ High-intensity interval training (HIIT) and linseed oil (LO) supplementation are effective strategies to reduce obesity-induced oxidative stress. Our aim was to determine whether the HIIT + LO combination prevents obesity-induced oxidative stress in high fat diet (HFD)-fed rats. HFD-fed 8-week-old, male, Wistar rats were subdivided in four groups: HFD, LO (2% of sunflower oil replaced with 2% of LO in the HFD), HIIT (4 days/week for 12 weeks), and HIIT + LO. Wistar rats fed a low-fat diet (LFD) were used as controls. Epididymal and subcutaneous adipose tissue, gastrocnemius muscle, liver, and plasma samples were collected to measure oxidative stress markers (AOPP, oxLDL), antioxidant (SOD, CAT, and GPx activities) and pro-oxidant (NOx and XO) enzyme activities. Compared with the LFD, the HFD altered the pro/antioxidant status in different tissues (increase of AOPP, oxLDL, SOD and catalase activities in plasma, and SOD activity increase in liver and decrease in adipose tissues) but not in gastrocnemius. LO upregulated CAT activity and decreased NOx in liver. HIIT alleviated HFD negative effects in liver by reducing SOD and NOx activities. Moreover, the HIIT + LO combination potentiated SOD activity upregulation in subcutaneous tissue. HIIT and LO supplementation have independent beneficial effects on the pro/antioxidant balance. Their association promotes SOD activity in subcutaneous adipose tissue.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Nitrates). 8001-26-1 (Linseed Oil). EC 1-11-1-6 (Catalase). EC 1-15-1-1 (Superoxide Dismutase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13103531
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Groussard&issn=2072-6643&title=Nutrients&atitle=Beneficial+Effects+of+High+Intensity+Interval+Training+and%2For+Linseed+Oil+Supplementation+to+Limit+Obesity-Induced+Oxidative+Stress+in+High+Fat+Diet-Fed+Rats.&volume=13&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fnu13103531&pmid=34684532&sid=OVID:medline
+
+<660>
+Unique Identifier
+ 34444660
+Title
+ Anti-Obesity and Hypocholesterolemic Actions of Protamine-Derived Peptide RPR (Arg-Pro-Arg) and Protamine in High-Fat Diet-Induced C57BL/6J Mice.
+Source
+ Nutrients. 13(8), 2021 Jul 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mijiti M; Mori R; Huang B; Tsukamoto K; Kiriyama K; Sutoh K; Nagaoka S
+Author NameID
+ Nagaoka, Satoshi; ORCID: https://orcid.org/0000-0002-5348-3187
+Authors Full Name
+ Mijiti, Maihemuti; Mori, Ryosuke; Huang, Bingyu; Tsukamoto, Kenichiro; Kiriyama, Keisuke; Sutoh, Keita; Nagaoka, Satoshi.
+Institution
+ Mijiti, Maihemuti. Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
+ Mori, Ryosuke. Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
+ Huang, Bingyu. Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
+ Tsukamoto, Kenichiro. Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
+ Kiriyama, Keisuke. Fordays Co., Ltd., Tokyo 103-0016, Japan.
+ Sutoh, Keita. Fordays Co., Ltd., Tokyo 103-0016, Japan.
+ Nagaoka, Satoshi. Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
+MeSH Subject Headings
+ *Adipose Tissue, White/de [Drug Effects]
+ Adipose Tissue, White/me [Metabolism]
+ Adipose Tissue, White/pp [Physiopathology]
+ Adiposity/de [Drug Effects]
+ Animals
+ *Anti-Obesity Agents/pd [Pharmacology]
+ *Anticholesteremic Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ *Cholesterol/bl [Blood]
+ Diet, High-Fat
+ Disease Models, Animal
+ Fatty Acid Synthase, Type I/ge [Genetics]
+ Fatty Acid Synthase, Type I/me [Metabolism]
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Male
+ Mice, Inbred C57BL
+ *Obesity/dt [Drug Therapy]
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ *Oligopeptides/pd [Pharmacology]
+ PPAR alpha/ge [Genetics]
+ PPAR alpha/me [Metabolism]
+ PPAR gamma/ge [Genetics]
+ PPAR gamma/me [Metabolism]
+ *Protamines/pd [Pharmacology]
+ Stearoyl-CoA Desaturase/ge [Genetics]
+ Stearoyl-CoA Desaturase/me [Metabolism]
+ Sterol Regulatory Element Binding Protein 1/ge [Genetics]
+ Sterol Regulatory Element Binding Protein 1/me [Metabolism]
+ Weight Loss/de [Drug Effects]
+ Mice
+Keyword Heading
+ RPR
+ cholesterol
+ fat
+ obesity
+ peptide
+ protamine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Dietary protamine can ameliorate hyperlipidemia; however, the protamine-derived active peptide and its hypolipidemic mechanism of action are unclear. Here, we report the discovery of a novel anti-obesity and hypocholesterolemic peptide, RPR (Arg-Pro-Arg), derived from protamine in mice fed a high-fat diet for 50 days. Serum cholesterol levels were significantly lower in the protamine and RPR groups than in the control group. White adipose tissue weight was significantly decreased in the protamine and RPR groups. The fecal excretion of cholesterol and bile acid was significantly higher in the protamine and RPR groups than in the control group. We also observed a significant decrease in the expression of hepatic SCD1, SREBP1, and adipocyte FAS mRNA, and significantly increased expression of hepatic PPARalpha and adipocyte PPARgamma1 mRNA in the protamine group. These findings demonstrate that the anti-obesity effects of protamine are linked to the upregulation of adipocyte PPARgamma1 and hepatic PPARalpha and the downregulation of hepatic SCD1 via SREBP1 and adipocyte FAS. RPR derived from protamine has a crucial role in the anti-obesity action of protamine by evaluating the effective dose of adipose tissue weight loss.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Anticholesteremic Agents). 0 (Biomarkers). 0 (Oligopeptides). 0 (PPAR alpha). 0 (PPAR gamma). 0 (Ppara protein, mouse). 0 (Pparg protein, mouse). 0 (Protamines). 0 (Srebf1 protein, mouse). 0 (Sterol Regulatory Element Binding Protein 1). 97C5T2UQ7J (Cholesterol). EC 1-14-19-1 (Scd1 protein, mouse). EC 1-14-19-1 (Stearoyl-CoA Desaturase). EC 2-3-1-85 (Fasn protein, mouse). EC 2-3-1-85 (Fatty Acid Synthase, Type I).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13082501
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mijiti&issn=2072-6643&title=Nutrients&atitle=Anti-Obesity+and+Hypocholesterolemic+Actions+of+Protamine-Derived+Peptide+RPR+%28Arg-Pro-Arg%29+and+Protamine+in+High-Fat+Diet-Induced+C57BL%2F6J+Mice.&volume=13&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fnu13082501&pmid=34444660&sid=OVID:medline
+
+<661>
+Unique Identifier
+ 34432833
+Title
+ Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.
+Source
+ PLoS ONE [Electronic Resource]. 16(8):e0256348, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Raychaudhuri S; Fan S; Kraus O; Shahinozzaman M; Obanda DN
+Author NameID
+ Fan, Si; ORCID: https://orcid.org/0000-0002-0367-5164
+ Obanda, Diana N; ORCID: https://orcid.org/0000-0002-4635-7887
+Authors Full Name
+ Raychaudhuri, Samnhita; Fan, Si; Kraus, Olivia; Shahinozzaman, Md; Obanda, Diana N.
+Institution
+ Raychaudhuri, Samnhita. Department of Nutrition and Food Sciences, University of Maryland, College Park, MD, United States of America.
+ Fan, Si. Department of Nutrition and Food Sciences, University of Maryland, College Park, MD, United States of America.
+ Kraus, Olivia. College of Computer, Mathematical and Natural Sciences, University of Maryland, College Park, MD, United States of America.
+ Shahinozzaman, Md. Department of Nutrition and Food Sciences, University of Maryland, College Park, MD, United States of America.
+ Obanda, Diana N. Department of Nutrition and Food Sciences, University of Maryland, College Park, MD, United States of America.
+MeSH Subject Headings
+ Adipose Tissue/pa [Pathology]
+ Adiposity
+ Animal Nutritional Physiological Phenomena
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight
+ *Brassica/ch [Chemistry]
+ Chemokines/ge [Genetics]
+ Chemokines/me [Metabolism]
+ Colon/me [Metabolism]
+ Cytokines/ge [Genetics]
+ Cytokines/me [Metabolism]
+ *Diet, High-Fat
+ *Dietary Supplements
+ Disease Models, Animal
+ Endotoxemia/bl [Blood]
+ Energy Intake
+ Feces
+ *Feeding Behavior
+ Gene Expression Regulation
+ Inflammation Mediators/me [Metabolism]
+ *Insulin Resistance
+ Lipids/bl [Blood]
+ Liver/pa [Pathology]
+ Male
+ Mice, Inbred C57BL
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ *Obesity/th [Therapy]
+ Organ Size
+ Mice
+Abstract
+ Cruciferous vegetables have been widely studied for cancer prevention and cardiovascular health. Broccoli is the cruciferous vegetable whose phytochemistry and physiological effects have been most extensively studied. Kale (Brassica oleracea var. acephala) appears on lists of 'healthiest, nutrient dense foods' but, there is paucity of data on kale as a functional food. In a 12-week study, we tested the effect of curly green kale on high fat diet (HFD) induced obesity and insulin resistance, lipid metabolism, endotoxemia and inflammation in C57BL/6J mice fed isocaloric diets. Kale supplementation did not attenuate HFD diet induced fat accumulation and insulin resistance (P = ns; n = 9) but, it lowered serum triglycerides, low density lipoprotein (LPL) cholesterol and prevented HFD induced increases in systemic endotoxemia and inflammation (serum LPS and Ccl2) (P<0.01; n = 9). In adipose tissue, kale enhanced the expression of genes involved in adipogenesis (P<0.01; n = 9), reduced the appearance of histologic markers of inflammation, downregulated both the gene expression and protein expression of the adipose tissue specific inflammation markers CD11c and F4/80 (P<0.001; n = 9) and reduced the gene expression of a battery of chemokine C-C motif ligands (Ccl2, Ccl6, Ccl7, Ccl8, Ccl9) and chemokine C-C motif receptors (Ccr2, Ccr3, Ccr5). We conclude that kale vegetable protects against HFD diet induced dysfunction through mechanisms involving lipid metabolism, endotoxemia and inflammation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Chemokines). 0 (Cytokines). 0 (Inflammation Mediators). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1371%2fjournal.pone.0256348
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Raychaudhuri&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Kale+supplementation+during+high+fat+feeding+improves+metabolic+health+in+a+mouse+model+of+obesity+and+insulin+resistance.&volume=16&issue=8&spage=e0256348&epage=&date=2021&doi=10.1371%2Fjournal.pone.0256348&pmid=34432833&sid=OVID:medline
+
+<662>
+Unique Identifier
+ 34363822
+Title
+ Low-molecular alginate improved diet-induced obesity and metabolic syndrome through modulating the gut microbiota in BALB/c mice.
+Source
+ International Journal of Biological Macromolecules. 187:811-820, 2021 Sep 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zheng W; Duan M; Jia J; Song S; Ai C
+Authors Full Name
+ Zheng, Weiyun; Duan, Mengmeng; Jia, Jinhui; Song, Shuang; Ai, Chunqing.
+Institution
+ Zheng, Weiyun. School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China.
+ Duan, Mengmeng. School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China.
+ Jia, Jinhui. School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China.
+ Song, Shuang. School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China; National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Dalian Polytechnic University, Dalian 116034, PR China.
+ Ai, Chunqing. School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China; National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Dalian Polytechnic University, Dalian 116034, PR China. Electronic address: acqdongying@163.com.
+MeSH Subject Headings
+ Adiposity
+ *Alginates
+ Animal Feed
+ Animals
+ *Bacteria/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Diet, High-Fat
+ Disease Models, Animal
+ Dysbiosis
+ Fecal Microbiota Transplantation
+ *Gastrointestinal Microbiome
+ Inflammation Mediators/me [Metabolism]
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/dh [Diet Therapy]
+ Metabolic Syndrome/mi [Microbiology]
+ Mice, Inbred BALB C
+ Molecular Weight
+ Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Obesity/mi [Microbiology]
+ *Prebiotics
+ Weight Gain
+ Mice
+Keyword Heading
+ Alginate
+ Fecal transplant
+ Gut microbiota
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Alginate is the most abundant polysaccharide in brown seaweed, which is widely used as a food additive, but its high viscosity and gel property limit its applications in foods as a functional ingredient. In this study, low-molecular alginate from Laminaria japonica (L-LJA) was prepared, and its effect on obesity and metabolic syndrome was analyzed in high-fat diet (HFD)-fed mice. L-LJA reduced weight gain, fat accumulation in the liver and epididymal adipose tissue, lipid abnormality and inflammation in HFD-fed mice accompanied with the improvement of gut microbiota. L-LJA modulated the structure of gut microbiota, increased some Bacteroidales members, and reduced some Clostridiales members in mice, which were positively correlated with the improvement of physiological status. Fecal transplant from L-LJA-fed mice reduced fat accumulation in body tissues and lipid abnormality in the serum and liver and increased short chain fatty acids production in HFD-fed mice, confirming that L-LJA-induced gut microbiota alteration played an important role in its bioactivity. L-LJA has better solubility and can be utilized in food systems in high dose, implying that it can be developed as a prebiotic agent to increase both economic value and nutritive value of alginate. Copyright © 2021 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Alginates). 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Lipids). 0 (Prebiotics).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.ijbiomac.2021.08.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zheng&issn=0141-8130&title=International+Journal+of+Biological+Macromolecules&atitle=Low-molecular+alginate+improved+diet-induced+obesity+and+metabolic+syndrome+through+modulating+the+gut+microbiota+in+BALB%2Fc+mice.&volume=187&issue=&spage=811&epage=820&date=2021&doi=10.1016%2Fj.ijbiomac.2021.08.003&pmid=34363822&sid=OVID:medline
+
+<663>
+Unique Identifier
+ 34274556
+Title
+ Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats.
+Source
+ Nutrition Research. 92:72-83, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vikoren LA; Drotningsvik A; Midttun O; McCann A; Bergseth MT; Austgulen MH; Mellgren G; Ueland PM; Gudbrandsen OA
+Authors Full Name
+ Vikoren, Linn A; Drotningsvik, Aslaug; Midttun, Oivind; McCann, Adrian; Bergseth, Marthe T; Austgulen, Maren H; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun A.
+Institution
+ Vikoren, Linn A. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway; Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
+ Drotningsvik, Aslaug. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
+ Midttun, Oivind. Bevital AS, 5021 Bergen, Norway.
+ McCann, Adrian. Bevital AS, 5021 Bergen, Norway.
+ Bergseth, Marthe T. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
+ Austgulen, Maren H. Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
+ Mellgren, Gunnar. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Haukeland University Hospital, 5020 Bergen, Norway; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5021 Bergen, Norway.
+ Ueland, Per Magne. Bevital AS, 5021 Bergen, Norway.
+ Gudbrandsen, Oddrun A. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. Electronic address: nkjgu@uib.no.
+MeSH Subject Headings
+ *Amino Acids/bl [Blood]
+ Amino Acids/ur [Urine]
+ Animals
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Cooking
+ *Diet
+ *Dietary Proteins/pd [Pharmacology]
+ Fasting
+ Feeding Behavior
+ Fish Proteins
+ *Gadus morhua
+ Kidney/me [Metabolism]
+ Liver/me [Metabolism]
+ Liver Diseases
+ Male
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/et [Etiology]
+ *Metabolic Syndrome/pa [Pathology]
+ Metabolic Syndrome/pc [Prevention & Control]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Postprandial Period
+ Rats, Zucker
+ *Seafood
+ Triglycerides/me [Metabolism]
+ Rats
+Keyword Heading
+ Amino acids
+ Cod
+ Fish fillet
+ Metabolic syndrome
+ Obese Zucker rat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with changes in amino acid metabolism, and studies show that ingestion of fish proteins influence amino acid composition in plasma and urine, in addition to affecting risk factors for metabolic syndrome. Since the majority of fish proteins consumed by humans are as fish fillet, it is of interest to investigate if cod fillet intake affects amino acid composition and metabolic disorders. We hypothesized that a modified AIN-93G diet containing cod fillet would affect amino acid compositions in plasma and urine in obese rats, and also affect risk factors for metabolic syndrome when compared to rats fed a regular AIN-93G diet with casein as the protein source. Obese Zucker fa/fa rats, a rat model of metabolic syndrome, received diets containing 25% protein from lyophilized baked cod fillet and 75% protein from casein (Baked cod diet), or a Control diet with casein for four weeks. The Baked cod diet affected the amino acid composition in plasma, with e.g., lower glycine, histidine, homoarginine, homocysteine, methionine, proline and tyrosine concentrations, but did not affect amino acid concentrations in urine. The concentrations of markers for kidney and liver dysfunction were lower in the Baked cod group, however blood pressure development, fasting and postprandial glucose, and hepatic triacylglycerol concentrations were similar to the Control group. To conclude, substituting 25% of dietary protein with baked cod fillet affected concentrations of some amino acids in plasma and delayed development of kidney and liver dysfunction, but did not affect blood pressure, glucose concentration or fatty liver. Copyright © 2021. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Amino Acids). 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Proteins). 0 (Fish Proteins). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.nutres.2021.05.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vikoren&issn=0271-5317&title=Nutrition+Research&atitle=Baked+cod+consumption+delayed+the+development+of+kidney+and+liver+dysfunction+and+affected+plasma+amino+acid+concentrations%2C+but+did+not+affect+blood+pressure%2C+blood+glucose+or+liver+triacylglycerol+concentrations+in+obese+fa%2Ffa+Zucker+rats.&volume=92&issue=&spage=72&epage=83&date=2021&doi=10.1016%2Fj.nutres.2021.05.009&pmid=34274556&sid=OVID:medline
+
+<664>
+Unique Identifier
+ 34245224
+Title
+ Inhibitory Effect of Garcinol on Obesity-Exacerbated, Colitis-Mediated Colon Carcinogenesis.
+Source
+ Molecular Nutrition & Food Research. 65(17):e2100410, 2021 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee PS; Nagabhushanam K; Ho CT; Pan MH
+Author NameID
+ Nagabhushanam, Kalyanam; ORCID: https://orcid.org/0000-0001-9470-4110
+ Pan, Min-Hsiung; ORCID: https://orcid.org/0000-0002-5188-7030
+Authors Full Name
+ Lee, Pei-Sheng; Nagabhushanam, Kalyanam; Ho, Chi-Tang; Pan, Min-Hsiung.
+Institution
+ Lee, Pei-Sheng. Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
+ Nagabhushanam, Kalyanam. Sabinsa Corporation, East Windsor, NJ, USA.
+ Ho, Chi-Tang. Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA.
+ Pan, Min-Hsiung. Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
+ Pan, Min-Hsiung. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.
+ Pan, Min-Hsiung. Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
+MeSH Subject Headings
+ Animals
+ *Anticarcinogenic Agents/pd [Pharmacology]
+ Azoxymethane/to [Toxicity]
+ Biomarkers/me [Metabolism]
+ Cell Proliferation/de [Drug Effects]
+ Colitis/ci [Chemically Induced]
+ Colitis/me [Metabolism]
+ Colitis/pa [Pathology]
+ Colonic Neoplasms/et [Etiology]
+ Colonic Neoplasms/pa [Pathology]
+ *Colonic Neoplasms/pc [Prevention & Control]
+ Cytokines/me [Metabolism]
+ Dextran Sulfate/to [Toxicity]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Dysbiosis/dt [Drug Therapy]
+ Gastrointestinal Microbiome/de [Drug Effects]
+ Gastrointestinal Microbiome/ph [Physiology]
+ Gene Expression Regulation, Neoplastic/de [Drug Effects]
+ Lipids/bl [Blood]
+ Male
+ Mice, Inbred C57BL
+ *Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Organ Size/de [Drug Effects]
+ Proliferating Cell Nuclear Antigen/me [Metabolism]
+ *Terpenes/pd [Pharmacology]
+ Mice
+Keyword Heading
+ RNA-sequencing
+ colorectal cancer
+ garcinol
+ microbiota
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ SCOPE: Epidemiological studies show a consistent and compelling association between the risk of colorectal cancer development and obesity, but its mechanisms remain poorly understood. Evidence is mounting that colorectal cancer can be prevented by nutritional supplements, such as phytochemicals. Garcinol, a polyisoprenylated benzophenone derivative, is widely present in Garcinia plants. This study investigates the potential role of garcinol supplementation in ameliorating obesity-induced colon cancer development.
+
+ METHODS AND RESULTS: An animal model to investigate the effect of high-fat-diet (HFD)-induced obesity on promoting colitis-associated colon cancer (AOM (azoxymethane)/DSS (dextran sodium sulfate)-induced) is designed. The results show that HFD can promote colitis-associated colon cancer as compared to an AOM/DSS group without the intervention of obesity, and supplementing with 0.05% garcinol in the diet can significantly ameliorate obesity-promoted colon carcinogenesis. The results also reveals that the microbiota composition of each group is significantly different and clustered. The most representative genera are Alistipes, Romboutsia, and Ruminococcus. The RNA-sequencing results show that the administration of garcinol can regulate genes and improve obesity-promoting colitis-associated colon carcinogenesis.
+
+ CONCLUSION: The study results suggest that garcinol can prevent obesity-promoted colorectal cancer, and these findings provide important niches for the future development of garcinol as functional foods or adjuvant therapeutic agents. Copyright © 2021 Wiley-VCH GmbH.
+Registry Number/Name of Substance
+ 0 (Anticarcinogenic Agents). 0 (Biomarkers). 0 (Cytokines). 0 (Lipids). 0 (Proliferating Cell Nuclear Antigen). 0 (Terpenes). 9042-14-2 (Dextran Sulfate). MO0N1J0SEN (Azoxymethane). TR1VR1V71B (garcinol).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1002%2fmnfr.202100410
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=1613-4125&title=Molecular+Nutrition+%26+Food+Research&atitle=Inhibitory+Effect+of+Garcinol+on+Obesity-Exacerbated%2C+Colitis-Mediated+Colon+Carcinogenesis.&volume=65&issue=17&spage=e2100410&epage=&date=2021&doi=10.1002%2Fmnfr.202100410&pmid=34245224&sid=OVID:medline
+
+<665>
+Unique Identifier
+ 34230537
+Title
+ Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice.
+Source
+ Scientific Reports. 11(1):13923, 2021 07 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Calvo E; Keiran N; Nunez-Roa C; Maymo-Masip E; Ejarque M; Sabadell-Basallote J; Del Mar Rodriguez-Pena M; Ceperuelo-Mallafre V; Seco J; Benaiges E; Michalopoulou T; Jorba R; Vendrell J; Fernandez-Veledo S
+Authors Full Name
+ Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Maymo-Masip, Elsa; Ejarque, Miriam; Sabadell-Basallote, Joan; Del Mar Rodriguez-Pena, Maria; Ceperuelo-Mallafre, Victoria; Seco, Jesus; Benaiges, Ester; Michalopoulou, Theodora; Jorba, Rosa; Vendrell, Joan; Fernandez-Veledo, Sonia.
+Institution
+ Calvo, Enrique. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Calvo, Enrique. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Keiran, Noelia. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Keiran, Noelia. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Keiran, Noelia. Universitat Rovira I Virgili, Tarragona, Spain.
+ Nunez-Roa, Catalina. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Nunez-Roa, Catalina. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Maymo-Masip, Elsa. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Maymo-Masip, Elsa. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Ejarque, Miriam. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Ejarque, Miriam. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Sabadell-Basallote, Joan. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Sabadell-Basallote, Joan. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Sabadell-Basallote, Joan. Universitat Rovira I Virgili, Tarragona, Spain.
+ Del Mar Rodriguez-Pena, Maria. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Del Mar Rodriguez-Pena, Maria. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Ceperuelo-Mallafre, Victoria. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Ceperuelo-Mallafre, Victoria. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Ceperuelo-Mallafre, Victoria. Universitat Rovira I Virgili, Tarragona, Spain.
+ Seco, Jesus. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Seco, Jesus. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Benaiges, Ester. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Benaiges, Ester. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain.
+ Benaiges, Ester. Universitat Rovira I Virgili, Tarragona, Spain.
+ Michalopoulou, Theodora. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain.
+ Jorba, Rosa. Servei de Cirurgia General I de L'Aparell Digestiu, Hospital Universitari Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), Tarragona, Spain.
+ Vendrell, Joan. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain. jvo@comt.es.
+ Vendrell, Joan. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain. jvo@comt.es.
+ Vendrell, Joan. Universitat Rovira I Virgili, Tarragona, Spain. jvo@comt.es.
+ Fernandez-Veledo, Sonia. Servei D'Endocrinologia I Nutricio I Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut D'Investigacio Sanitaria Pere Virgili (IISPV), c/ Dr. Mallafre Guasch 4, 43007, Tarragona, Spain. sonia.fernandezveledo@gmail.com.
+ Fernandez-Veledo, Sonia. CIBER de Diabetes Y Enfermedades Metabolicas Asociadas (CIBERDEM) - Instituto de Salud Carlos III, Madrid, Spain. sonia.fernandezveledo@gmail.com.
+MeSH Subject Headings
+ *Adipose Tissue, White/pa [Pathology]
+ Adrenal Gland Neoplasms/pa [Pathology]
+ Animals
+ Biomarkers/me [Metabolism]
+ *Diet
+ Female
+ Gene Expression Regulation
+ Glucose/me [Metabolism]
+ Humans
+ Inflammation/ge [Genetics]
+ Lipid Metabolism/ge [Genetics]
+ Male
+ Mice, Inbred C57BL
+ Middle Aged
+ *Obesity/pa [Pathology]
+ Pheochromocytoma/pa [Pathology]
+ *Stem Cells/pa [Pathology]
+ Weight Gain
+ Mice
+Abstract
+ Adipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. Despite the recent identification of brown adipose tissue (BAT) as a potential target in the management of obesity, the use of ASCs isolated from BAT as a therapy for patients with obesity has not yet been explored. Metabolic activation of BAT has been shown to have not only thermogenic effects, but it also triggers the secretion of factors that confer protection against obesity. Herein, we isolated and characterized ASCs from the visceral adipose tissue surrounding a pheochromocytoma (IB-hASCs), a model of inducible BAT in humans. We then compared the anti-obesity properties of IB-hASCs and human ASCs isolated from visceral white adipose tissue (W-hASCs) in a murine model of diet-induced obesity. We found that both ASC therapies mitigated the metabolic abnormalities of obesity to a similar extent, including reducing weight gain and improving glucose tolerance. However, infusion of IB-hASCs was superior to W-hASCs in suppressing lipogenic and inflammatory markers, as well as preserving insulin secretion. Our findings provide evidence for the metabolic benefits of visceral ASC infusion and support further studies on IB-hASCs as a therapeutic option for obesity-related comorbidities.
+Registry Number/Name of Substance
+ 0 (Biomarkers). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-93224-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Calvo&issn=2045-2322&title=Scientific+Reports&atitle=Effects+of+stem+cells+from+inducible+brown+adipose+tissue+on+diet-induced+obesity+in+mice.&volume=11&issue=1&spage=13923&epage=&date=2021&doi=10.1038%2Fs41598-021-93224-6&pmid=34230537&sid=OVID:medline
+
+<666>
+Unique Identifier
+ 34192532
+Title
+ A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
+Source
+ Cell Reports. 35(13):109301, 2021 06 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Geisler CE; Ghimire S; Bruggink SM; Miller KE; Weninger SN; Kronenfeld JM; Yoshino J; Klein S; Duca FA; Renquist BJ
+Authors Full Name
+ Geisler, Caroline E; Ghimire, Susma; Bruggink, Stephanie M; Miller, Kendra E; Weninger, Savanna N; Kronenfeld, Jason M; Yoshino, Jun; Klein, Samuel; Duca, Frank A; Renquist, Benjamin J.
+Institution
+ Geisler, Caroline E. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
+ Ghimire, Susma. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA.
+ Bruggink, Stephanie M. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA.
+ Miller, Kendra E. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA.
+ Weninger, Savanna N. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA.
+ Kronenfeld, Jason M. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA.
+ Yoshino, Jun. Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA.
+ Klein, Samuel. Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA.
+ Duca, Frank A. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA.
+ Renquist, Benjamin J. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA. Electronic address: bjrenquist@email.arizona.edu.
+MeSH Subject Headings
+ 4-Aminobutyrate Transaminase/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat
+ Energy Metabolism
+ Feeding Behavior
+ Glucose/me [Metabolism]
+ Glucose Clamp Technique
+ Homeostasis
+ Humans
+ Hyperinsulinism/co [Complications]
+ Hyperinsulinism/me [Metabolism]
+ Hyperinsulinism/pp [Physiopathology]
+ Hyperphagia/co [Complications]
+ *Hyperphagia/me [Metabolism]
+ *Hyperphagia/pp [Physiopathology]
+ Insulin Resistance
+ Liver/ir [Innervation]
+ *Liver/me [Metabolism]
+ *Liver/pp [Physiopathology]
+ Male
+ Mice, Inbred C57BL
+ Mice, Obese
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Vagotomy
+ Vagus Nerve/pp [Physiopathology]
+ *gamma-Aminobutyric Acid/me [Metabolism]
+ Mice
+Keyword Heading
+ GABA
+ GABA shunt
+ GABA transaminase
+ NAFLD
+ NASH
+ Type 2 diabetes mellitus
+ hyperinsulinemia
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Hepatic lipid accumulation is a hallmark of type II diabetes (T2D) associated with hyperinsulinemia, insulin resistance, and hyperphagia. Hepatic synthesis of GABA, catalyzed by GABA-transaminase (GABA-T), is upregulated in obese mice. To assess the role of hepatic GABA production in obesity-induced metabolic and energy dysregulation, we treated mice with two pharmacologic GABA-T inhibitors and knocked down hepatic GABA-T expression using an antisense oligonucleotide. Hepatic GABA-T inhibition and knockdown decreased basal hyperinsulinemia and hyperglycemia and improved glucose intolerance. GABA-T knockdown improved insulin sensitivity assessed by hyperinsulinemic-euglycemic clamps in obese mice. Hepatic GABA-T knockdown also decreased food intake and induced weight loss without altering energy expenditure in obese mice. Data from people with obesity support the notion that hepatic GABA production and transport are associated with serum insulin, homeostatic model assessment for insulin resistance (HOMA-IR), T2D, and BMI. These results support a key role for hepatocyte GABA production in the dysfunctional glucoregulation and feeding behavior associated with obesity. Copyright Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 56-12-2 (gamma-Aminobutyric Acid). EC 2-6-1-19 (4-Aminobutyrate Transaminase). IY9XDZ35W2 (Glucose).
+Publication Type
+ Clinical Trial. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.celrep.2021.109301
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Geisler&issn=2211-1247&title=Cell+Reports&atitle=A+critical+role+of+hepatic+GABA+in+the+metabolic+dysfunction+and+hyperphagia+of+obesity.&volume=35&issue=13&spage=109301&epage=&date=2021&doi=10.1016%2Fj.celrep.2021.109301&pmid=34192532&sid=OVID:medline
+
+<667>
+Unique Identifier
+ 34097961
+Title
+ A homogeneous polysaccharide from Lycium barbarum: Structural characterizations, anti-obesity effects and impacts on gut microbiota.
+Source
+ International Journal of Biological Macromolecules. 183:2074-2087, 2021 Jul 31.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang Y; Chang Y; Wu Y; Liu H; Liu Q; Kang Z; Wu M; Yin H; Duan J
+Authors Full Name
+ Yang, Yu; Chang, Yifan; Wu, Yi; Liu, Hairong; Liu, Qishan; Kang, Zuzhe; Wu, Man; Yin, Hong; Duan, Jinyou.
+Institution
+ Yang, Yu. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi, China.
+ Chang, Yifan. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi, China.
+ Wu, Yi. College of Plant Protection, Northwest A&F University, Yangling, 712100, Shaanxi, China.
+ Liu, Hairong. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi, China.
+ Liu, Qishan. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi, China.
+ Kang, Zuzhe. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi, China.
+ Wu, Man. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi, China.
+ Yin, Hong. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi, China. Electronic address: yinhong@nwsuaf.edu.cn.
+ Duan, Jinyou. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi, China. Electronic address: jduan@nwsuaf.edu.cn.
+MeSH Subject Headings
+ Animals
+ Anti-Obesity Agents/ch [Chemistry]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Arabinose/ch [Chemistry]
+ Arabinose/pd [Pharmacology]
+ *Bacteria/de [Drug Effects]
+ Bacteria/gd [Growth & Development]
+ Bacteria/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ Disease Models, Animal
+ Drugs, Chinese Herbal/ch [Chemistry]
+ *Drugs, Chinese Herbal/pd [Pharmacology]
+ Dysbiosis
+ *Energy Metabolism/de [Drug Effects]
+ Fatty Acids/bl [Blood]
+ Galactose/ch [Chemistry]
+ Galactose/pd [Pharmacology]
+ *Gastrointestinal Microbiome/de [Drug Effects]
+ Male
+ Mice, Inbred C57BL
+ Molecular Structure
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Obesity/mi [Microbiology]
+ *Prebiotics
+ Rhamnose/ch [Chemistry]
+ Rhamnose/pd [Pharmacology]
+ Structure-Activity Relationship
+ Mice
+Keyword Heading
+ Gut microbiota
+ Lycium barbarum polysaccharide
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Lycium barbarum polysaccharides (LBPs) are known for their beneficial effects on diabetes, NAFLD and related chronic metabolic diseases induced by high-fat diet (HFD). However, the relevant researches are mainly about the whole crude polysaccharides, the specific active ingredient of LBPs and its bioactivity have been rarely explored. Herein, a homogeneous polysaccharide (LBP-W) was isolated and purified from crude LBPs. Structure characterizations indicated that LBP-W contained a main chain consisting of a repeated unit of ->6)-beta-Galp(1 -> residues with branches composed of alpha-Araf, beta-Galp and alpha-Rhap residues at position C-3. The objective of this study was to evaluate the anti-obesogenic effect of LBP-W and figure out the underlying mechanisms. In vivo efficacy trial illustrated that LBP-W supplements can alleviate HFD-induced mice obesity significantly. Gut microbiota analysis showed that LBP-W not only improved community diversity of intestinal flora, but also regulated their specific genera. Moreover, LBP-W can increase the content of short-chain fatty acids (SCFAs), a metabolite of the intestinal flora. In summary, all these results demonstrated that the homogeneous polysaccharide purified from L. barbarum could be used as a prebiotic agent to improve obesity by modulating the composition of intestinal flora and the metabolism of SCFAs. Copyright © 2021. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Blood Glucose). 0 (Drugs, Chinese Herbal). 0 (Fatty Acids). 0 (Prebiotics). 0 (lycium barbarum polysaccharide). B40ROO395Z (Arabinose). QN34XC755A (Rhamnose). X2RN3Q8DNE (Galactose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.ijbiomac.2021.05.209
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=0141-8130&title=International+Journal+of+Biological+Macromolecules&atitle=A+homogeneous+polysaccharide+from+Lycium+barbarum%3A+Structural+characterizations%2C+anti-obesity+effects+and+impacts+on+gut+microbiota.&volume=183&issue=&spage=2074&epage=2087&date=2021&doi=10.1016%2Fj.ijbiomac.2021.05.209&pmid=34097961&sid=OVID:medline
+
+<668>
+Unique Identifier
+ 34000207
+Title
+ Voluntary running of defined distances alters bone microstructure in C57BL/6 mice fed a high-fat diet.
+Source
+ Applied Physiology, Nutrition, & Metabolism = Physiologie Appliquee, Nutrition et Metabolisme. 46(11):1337-1344, 2021 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yan L; Nielsen FH; Sundaram S; Cao J
+Authors Full Name
+ Yan, Lin; Nielsen, Forrest H; Sundaram, Sneha; Cao, Jay.
+Institution
+ Yan, Lin. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
+ Yan, Lin. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
+ Nielsen, Forrest H. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
+ Nielsen, Forrest H. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
+ Sundaram, Sneha. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
+ Sundaram, Sneha. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
+ Cao, Jay. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
+ Cao, Jay. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Body Weight
+ *Bone Density
+ Bone Resorption
+ *Cancellous Bone/ah [Anatomy & Histology]
+ Cancellous Bone/me [Metabolism]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Energy Intake
+ Femur/ah [Anatomy & Histology]
+ Femur/me [Metabolism]
+ Glycoproteins/bl [Blood]
+ Male
+ Mice, Inbred C57BL
+ Obesity/pa [Pathology]
+ Obesity/pp [Physiopathology]
+ *Physical Conditioning, Animal/ph [Physiology]
+ *Running/ph [Physiology]
+ Spine/ah [Anatomy & Histology]
+ Spine/me [Metabolism]
+ Tartrate-Resistant Acid Phosphatase/bl [Blood]
+ X-Ray Microtomography
+ Mice
+Keyword Heading
+ C57BL/6 mice
+ bone
+ cortical
+ course
+ high-fat diet
+ os
+ running
+ regime riche en graisses
+ souris C57BL/6
+ trabecular
+ trabeculaire
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity increases the risk for pathological conditions such as bone loss. On the other hand, physical exercise reduces body adiposity. To test the hypothesis that physical activity improves bone quality, we evaluated voluntary running of defined distances on trabecular and cortical microstructure in mice fed a high-fat diet (HFD). Sedentary mice were fed the standard AIN93G diet or the HFD. Mice fed the HFD remained sedentary or were assigned to unrestricted running or 75%, 50%, and 25% of unrestricted running with an average running activity at 8.3, 6.3, 4.2, and 2.1 km per day, respectively. The bone structural differences found in sedentary mice were that HFD, compared with the AIN93G diet, resulted in a lower bone volume fraction (BV/TV) and a higher structure model index (SMI) in vertebrae. Running had a greater effect on trabecular microstructure in femurs than in vertebrae; the decrease in SMI and an increase in trabecular thickness (Tb.Th) were in dose-dependent manners. Running was positively correlated with BV/TV and Tb.Th and inversely correlated with SMI in femurs. The HFD increased plasma concentrations of tartrate-resistant acid phosphatase 5b, a marker of bone resorption, in sedentary mice, while running decreased it in a dose-dependent manner. The findings show that voluntary running improves bone quality in young adult mice fed an HFD. Novelty: The high-fat diet alters bone microstructure by increasing bone resorption. Quantitative voluntary running improves bone microstructure through its attenuation of bone resorption in mice fed a high-fat diet.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycoproteins). 0 (nephrocalcin). EC 3-1-3-2 (Acp5 protein, mouse). EC 3-1-3-2 (Tartrate-Resistant Acid Phosphatase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1139%2fapnm-2021-0061
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yan&issn=1715-5312&title=Applied+Physiology%2C+Nutrition%2C+%26+Metabolism+%3D+Physiologie+Appliquee%2C+Nutrition+et+Metabolisme&atitle=Voluntary+running+of+defined+distances+alters+bone+microstructure+in+C57BL%2F6+mice+fed+a+high-fat+diet.&volume=46&issue=11&spage=1337&epage=1344&date=2021&doi=10.1139%2Fapnm-2021-0061&pmid=34000207&sid=OVID:medline
+
+<669>
+Unique Identifier
+ 33917566
+Title
+ A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases.
+Source
+ Cells. 10(4), 2021 04 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mazier W; Le Corf K; Martinez C; Tudela H; Kissi D; Kropp C; Coubard C; Soto M; Elustondo F; Rawadi G; Claus SP
+Author NameID
+ Mazier, Wilfrid; ORCID: https://orcid.org/0000-0001-5434-7542
+ Kropp, Camille; ORCID: https://orcid.org/0000-0001-7650-9506
+ Claus, Sandrine P; ORCID: https://orcid.org/0000-0002-3789-9780
+Authors Full Name
+ Mazier, Wilfrid; Le Corf, Katy; Martinez, Ccori; Tudela, Heloise; Kissi, Deborah; Kropp, Camille; Coubard, Chrislain; Soto, Marion; Elustondo, Frederic; Rawadi, Georges; Claus, Sandrine P.
+Institution
+ Mazier, Wilfrid. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Le Corf, Katy. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Martinez, Ccori. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Tudela, Heloise. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Kissi, Deborah. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Kropp, Camille. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Kropp, Camille. Micalis Institute, INRAE, AgroParisTech, University Paris-Saclay, 78350 Jouy-en-Josas, France.
+ Coubard, Chrislain. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Soto, Marion. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Elustondo, Frederic. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Rawadi, Georges. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+ Claus, Sandrine P. Ysopia Bioscience, 17 place de la Bourse, 33076 Bordeaux, France.
+MeSH Subject Headings
+ Animals
+ Biodiversity
+ *Biological Therapy
+ Biomarkers/me [Metabolism]
+ Clostridiales/cl [Classification]
+ *Clostridiales/ip [Isolation & Purification]
+ Diet
+ Disease Models, Animal
+ Epithelial Cells/me [Metabolism]
+ Feces/mi [Microbiology]
+ Gastrointestinal Microbiome
+ Humans
+ Lipid Metabolism
+ Liver/me [Metabolism]
+ Male
+ *Metabolic Diseases/mi [Microbiology]
+ *Metabolic Diseases/th [Therapy]
+ Mice, Inbred C57BL
+ *Obesity/mi [Microbiology]
+ *Obesity/th [Therapy]
+ Phylogeny
+ Mice
+Keyword Heading
+ metabolic disorders
+ microbiome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with gut microbiota dysbiosis, characterized by a high Firmicutes/Bacteroidetes ratio. Gut-dwelling bacteria of the Christensenellaceae family have been proposed to act as keystones of the human gut ecosystem and to prevent adipogenesis. The objectives of the present study were to demonstrate the antiobesity potential of a new strain of Christensenella minuta in preclinical models and explore related mechanisms of action. The antiobesity potential of C. minuta DSM33407 was assessed in a diet-induced obesity mouse model. Changes in hepatic lipid metabolism were explored using targeted transcriptomics. Effects on gut microbiota were further assessed in a humanized Simulator of the Human Intestinal Microbial Ecosystem (SHIME R) model inoculated with obese fecal samples. Shotgun metagenomics was applied to study microbial community structures in both models. C. minuta DSM33407 protected from diet-induced obesity and regulated associated metabolic markers such as glycemia and leptin. It also regulated hepatic lipid metabolism through a strong inhibition of de novo lipogenesis and maintained gut epithelial integrity. In the humanized SHIME R model, these effects were associated with modulations of the intestinal microbiota characterized by a decreased Firmicutes/Bacteroidetes ratio. These data indicate that C. minuta DSM33407 is a convincing therapeutic candidate for the management of obesity and associated metabolic disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fcells10040823
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mazier&issn=2073-4409&title=Cells&atitle=A+New+Strain+of+Christensenella+minuta+as+a+Potential+Biotherapy+for+Obesity+and+Associated+Metabolic+Diseases.&volume=10&issue=4&spage=&epage=&date=2021&doi=10.3390%2Fcells10040823&pmid=33917566&sid=OVID:medline
+
+<670>
+Unique Identifier
+ 34670603
+Title
+ Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals.
+Source
+ Clinical Epigenetics. 13(1):195, 2021 10 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen Y; Kassam I; Lau SH; Kooner JS; Wilson R; Peters A; Winkelmann J; Chambers JC; Chow VT; Khor CC; van Dam RM; Teo YY; Loh M; Sim X
+Author NameID
+ Loh, Marie; ORCID: https://orcid.org/0000-0003-3626-8466
+ Sim, Xueling; ORCID: https://orcid.org/0000-0002-1233-7642
+Authors Full Name
+ Chen, Yuqing; Kassam, Irfahan; Lau, Suk Hiang; Kooner, Jaspal S; Wilson, Rory; Peters, Annette; Winkelmann, Juliane; Chambers, John C; Chow, Vincent T; Khor, Chiea Chuen; van Dam, Rob M; Teo, Yik-Ying; Loh, Marie; Sim, Xueling.
+Institution
+ Chen, Yuqing. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-01, Tahir Foundation Building, Singapore, 117549, Singapore.
+ Kassam, Irfahan. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-01, Tahir Foundation Building, Singapore, 117549, Singapore.
+ Kassam, Irfahan. Life Sciences Institute, National University of Singapore, Singapore, Singapore.
+ Lau, Suk Hiang. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
+ Kooner, Jaspal S. Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UK.
+ Kooner, Jaspal S. Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
+ Kooner, Jaspal S. MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
+ Kooner, Jaspal S. National Heart and Lung Institute, Imperial College London, London, UK.
+ Wilson, Rory. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764, Neuherberg, Bavaria, Germany.
+ Peters, Annette. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Peters, Annette. German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
+ Winkelmann, Juliane. Institute of Neurogenomics, Helmholtz Zentrum Munchen, Munich, Germany.
+ Winkelmann, Juliane. Institute of Human Genetics, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.
+ Winkelmann, Juliane. Lehrstuhl Fur Neurogenetik, Technische Universitat Munchen, Munich, Germany.
+ Winkelmann, Juliane. Munich Cluster for Systems Neurology, Munich, Germany.
+ Chambers, John C. Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UK.
+ Chambers, John C. Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
+ Chambers, John C. MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
+ Chambers, John C. Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Level 18, Lee Kong Chian Clinical Science Building, Singapore, 308232, Singapore.
+ Chambers, John C. Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
+ Chow, Vincent T. National University Health System Infectious Diseases Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
+ Khor, Chiea Chuen. Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
+ Khor, Chiea Chuen. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
+ van Dam, Rob M. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-01, Tahir Foundation Building, Singapore, 117549, Singapore.
+ van Dam, Rob M. Department of Nutrition and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Teo, Yik-Ying. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-01, Tahir Foundation Building, Singapore, 117549, Singapore.
+ Teo, Yik-Ying. Life Sciences Institute, National University of Singapore, Singapore, Singapore.
+ Loh, Marie. Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Level 18, Lee Kong Chian Clinical Science Building, Singapore, 308232, Singapore. marie_loh@ntu.edu.sg.
+ Loh, Marie. Department of Epidemiology and Biostatistics, Imperial College London, London, UK. marie_loh@ntu.edu.sg.
+ Loh, Marie. National Skin Centre, Singapore, Singapore. marie_loh@ntu.edu.sg.
+ Sim, Xueling. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-01, Tahir Foundation Building, Singapore, 117549, Singapore. ephsx@nus.edu.sg.
+MeSH Subject Headings
+ Analysis of Variance
+ Asian People/eh [Ethnology]
+ *Asian People/ge [Genetics]
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ DNA Methylation/ge [Genetics]
+ DNA Methylation/ph [Physiology]
+ *Genome-Wide Association Study/mt [Methods]
+ Genome-Wide Association Study/sn [Statistics & Numerical Data]
+ Humans
+ Obesity/ge [Genetics]
+ *Waist Circumference/ge [Genetics]
+Keyword Heading
+ Body mass index
+ DNA methylation
+ Epigenome-wide association study
+ Inflammation
+ Metabolites
+ Obesity
+ Waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation in BMI. Recent studies reported associations between DNA methylation and obesity, mostly in non-Asian populations.
+
+ METHODS: We performed an epigenome-wide association study (EWAS) on general adiposity (body mass index, BMI) and abdominal adiposity (waist circumference, WC) in 409 multi-ethnic Asian individuals and replicated BMI and waist-associated DNA methylation CpGs identified in other populations. The cross-lagged panel model and Mendelian randomization were used to assess the temporal relationship between methylation and BMI. The temporal relationship between the identified CpGs and inflammation and metabolic markers was also examined.
+
+ RESULTS: EWAS identified 116 DNA methylation CpGs independently associated with BMI and eight independently associated with WC at false discovery rate PFDR < 0.05 in 409 Asian samples. We replicated 110 BMI-associated CpGs previously reported in Europeans and identified six novel BMI-associated CpGs and two novel WC-associated CpGs. We observed high consistency in association direction of effect compared to studies in other populations. Causal relationship analyses indicated that BMI was more likely to be the cause of DNA methylation alteration, rather than the consequence. The causal analyses using BMI-associated methylation risk score also suggested that higher levels of the inflammation marker IL-6 were likely the consequence of methylation change.
+
+ CONCLUSION: Our study provides evidence of an association between obesity and DNA methylation in multi-ethnic Asians and suggests that obesity can drive methylation change. The results also suggested possible causal influence that obesity-related methylation changes might have on inflammation and lipoprotein levels. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs13148-021-01162-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1868-7075&title=Clinical+Epigenetics&atitle=Impact+of+BMI+and+waist+circumference+on+epigenome-wide+DNA+methylation+and+identification+of+epigenetic+biomarkers+in+blood%3A+an+EWAS+in+multi-ethnic+Asian+individuals.&volume=13&issue=1&spage=195&epage=&date=2021&doi=10.1186%2Fs13148-021-01162-x&pmid=34670603&sid=OVID:medline
+
+<671>
+Unique Identifier
+ 34475432
+Title
+ Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.
+Source
+ Scientific Reports. 11(1):17571, 2021 09 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cimino I; Rimmington D; Tung YCL; Lawler K; Larraufie P; Kay RG; Virtue S; Lam BYH; Fagnocchi L; Ma MKL; Saudek V; Zvetkova I; Vidal-Puig A; Yeo GSH; Farooqi IS; Pospisilik JA; Gribble FM; Reimann F; O'Rahilly S; Coll AP
+Authors Full Name
+ Cimino, Irene; Rimmington, Debra; Tung, Y C Loraine; Lawler, Katherine; Larraufie, Pierre; Kay, Richard G; Virtue, Samuel; Lam, Brian Y H; Fagnocchi, Luca; Ma, Marcella K L; Saudek, Vladimir; Zvetkova, Ilona; Vidal-Puig, Antonio; Yeo, Giles S H; Farooqi, I Sadaf; Pospisilik, J Andrew; Gribble, Fiona M; Reimann, Frank; O'Rahilly, Stephen; Coll, Anthony P.
+Institution
+ Cimino, Irene. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Rimmington, Debra. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Tung, Y C Loraine. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Lawler, Katherine. University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Larraufie, Pierre. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Larraufie, Pierre. Universite Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005, Paris, France.
+ Kay, Richard G. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Virtue, Samuel. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Lam, Brian Y H. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Fagnocchi, Luca. Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA.
+ Ma, Marcella K L. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Saudek, Vladimir. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Zvetkova, Ilona. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Vidal-Puig, Antonio. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Yeo, Giles S H. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Farooqi, I Sadaf. University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Pospisilik, J Andrew. Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA.
+ Gribble, Fiona M. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Reimann, Frank. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ O'Rahilly, Stephen. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK.
+ Coll, Anthony P. MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0SL, UK. apc36@cam.ac.uk.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight
+ Diet, High-Fat
+ *Eating/ph [Physiology]
+ Energy Metabolism
+ Female
+ Gene Expression Profiling
+ Male
+ *Membrane Proteins/me [Metabolism]
+ Mice
+ Mice, Inbred C57BL
+ Mice, Knockout
+ *Nerve Tissue Proteins/me [Metabolism]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+Abstract
+ Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat+/-p mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient mice on chow diet displayed a bimodal body weight phenotype with more than 30% of Nnat+/-p mice developing obesity. In response to both a 45% high fat diet and exposure to thermoneutrality (30 degreeC) Nnat deficient mice maintained the hypervariable body weight phenotype. Within a calorimetry system, food intake in Nnat+/-p mice was hypervariable, with some mice consuming more than twice the intake seen in wild type littermates. A hyperphagic response was also seen in Nnat+/-p mice in a second, non-home cage environment. An expected correlation between body weight and energy expenditure was seen, but corrections for the effects of positive energy balance and body weight greatly diminished the effect of neuronatin deficiency on energy expenditure. Male and female Nnat+/-p mice displayed subtle distinctions in the degree of variance body weight phenotype and food intake and further sexual dimorphism was reflected in different patterns of hypothalamic gene expression in Nnat+/-p mice. Loss of the imprinted gene Nnat is associated with a highly variable food intake, with the impact of this phenotype varying between genetically identical individuals. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Membrane Proteins). 0 (Nerve Tissue Proteins). 0 (Nnat protein, mouse).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-96278-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cimino&issn=2045-2322&title=Scientific+Reports&atitle=Murine+neuronatin+deficiency+is+associated+with+a+hypervariable+food+intake+and+bimodal+obesity.&volume=11&issue=1&spage=17571&epage=&date=2021&doi=10.1038%2Fs41598-021-96278-8&pmid=34475432&sid=OVID:medline
+
+<672>
+Unique Identifier
+ 34303710
+Title
+ Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature.
+Source
+ Biochemical Pharmacology. 193:114698, 2021 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim S; Choi S; Dutta M; Asubonteng JO; Polunas M; Goedken M; Gonzalez FJ; Cui JY; Gyamfi MA
+Authors Full Name
+ Kim, Sarah; Choi, Sora; Dutta, Moumita; Asubonteng, Jeffrey O; Polunas, Marianne; Goedken, Michael; Gonzalez, Frank J; Cui, Julia Yue; Gyamfi, Maxwell A.
+Institution
+ Kim, Sarah. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
+ Choi, Sora. Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
+ Dutta, Moumita. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
+ Asubonteng, Jeffrey O. Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
+ Polunas, Marianne. Office of Research and Economic Development, Research Pathology Services, Rutgers University, Piscataway, NJ, USA.
+ Goedken, Michael. Office of Research and Economic Development, Research Pathology Services, Rutgers University, Piscataway, NJ, USA.
+ Gonzalez, Frank J. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
+ Cui, Julia Yue. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: juliacui@uw.edu.
+ Gyamfi, Maxwell A. Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA. Electronic address: mgyamfi@uthsc.edu.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Diet, High-Fat/ae [Adverse Effects]
+ Female
+ *Gastrointestinal Microbiome/ph [Physiology]
+ Gene Regulatory Networks
+ Glucose Tolerance Test
+ *Inflammation/me [Metabolism]
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Knockout
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Obesity/me [Metabolism]
+ Pregnane X Receptor/ge [Genetics]
+ *Pregnane X Receptor/me [Metabolism]
+ RNA, Bacterial/ge [Genetics]
+ RNA, Ribosomal, 16S
+ Sex Factors
+Keyword Heading
+ Gut microbiome
+ High-fat diet
+ NAFLD
+ Obesity
+ PXR
+ Sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease due to the current epidemics of obesity and diabetes. The pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor known for trans-activating liver genes involved in drug metabolism and transport, and more recently implicated in energy metabolism. The gut microbiota can modulate the host xenobiotic biotransformation and contribute to the development of obesity. While the male sex confers a higher risk for NAFLD than women before menopause, the mechanism remains unknown. We hypothesized that the presence of PXR promotes obesity by modifying the gut-liver axis in a sex-specific manner. Male and female C57BL/6 (wild-type/WT) and PXR-knockout (PXR-KO) mice were fed control or high-fat diet (HFD) for 16-weeks. Serum parameters, liver histopathology, transcriptomic profiling, 16S-rDNA sequencing, and bile acid (BA) metabolomics were performed. PXR enhanced HFD-induced weight gain, hepatic steatosis and inflammation especially in males, accompanied by PXR-dependent up-regulation in hepatic genes involved in microbial response, inflammation, oxidative stress, and cancer; PXR-dependent increase in intestinal Firmicutes/Bacteroides ratio (hallmark of obesity) and the pro-inflammatory Lactobacillus, as well as a decrease in the anti-obese Allobaculum and the anti-inflammatory Bifidobacterum, with a PXR-dependent reduction of beneficial BAs in liver. The resistance to NAFLD in females may be explained by PXR-dependent decrease in pro-inflammatory bacteria (Ruminococcus gnavus and Peptococcaceae). In conclusion, PXR exacerbates hepatic steatosis and inflammation accompanied by obesity- and inflammation-prone gut microbiome signature, suggesting that gut microbiome may contribute to PXR-mediated exacerbation of NAFLD. Copyright Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Nr1i2 protein, mouse). 0 (Pregnane X Receptor). 0 (RNA, Bacterial). 0 (RNA, Ribosomal, 16S).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.bcp.2021.114698
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=0006-2952&title=Biochemical+Pharmacology&atitle=Pregnane+X+receptor+exacerbates+nonalcoholic+fatty+liver+disease+accompanied+by+obesity-+and+inflammation-prone+gut+microbiome+signature.&volume=193&issue=&spage=114698&epage=&date=2021&doi=10.1016%2Fj.bcp.2021.114698&pmid=34303710&sid=OVID:medline
+
+<673>
+Unique Identifier
+ 34375388
+Title
+ Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic.
+Source
+ American Journal of Clinical Nutrition. 114(5):1655-1665, 2021 11 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cauwenberghs N; Prunicki M; Sabovcik F; Perelman D; Contrepois K; Li X; Snyder MP; Nadeau KC; Kuznetsova T; Haddad F; Gardner CD
+Author NameID
+ Cauwenberghs, Nicholas; ORCID: https://orcid.org/0000-0001-8059-7692
+ Prunicki, Mary; ORCID: https://orcid.org/0000-0002-5511-8896
+ Sabovcik, Frantisek; ORCID: https://orcid.org/0000-0001-8275-6431
+ Perelman, Dalia; ORCID: https://orcid.org/0000-0003-3335-1950
+ Snyder, Michael P; ORCID: https://orcid.org/0000-0003-0784-7987
+ Nadeau, Kari C; ORCID: https://orcid.org/0000-0002-2146-2955
+ Haddad, Francois; ORCID: https://orcid.org/0000-0002-9648-7671
+ Gardner, Christopher D; ORCID: https://orcid.org/0000-0002-7596-1530
+Authors Full Name
+ Cauwenberghs, Nicholas; Prunicki, Mary; Sabovcik, Frantisek; Perelman, Dalia; Contrepois, Kevin; Li, Xiao; Snyder, Michael P; Nadeau, Kari C; Kuznetsova, Tatiana; Haddad, Francois; Gardner, Christopher D.
+Institution
+ Cauwenberghs, Nicholas. Stanford Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, CA, USA.
+ Cauwenberghs, Nicholas. Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
+ Prunicki, Mary. Sean N Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA.
+ Prunicki, Mary. Department of Medicine, Stanford University, Stanford, CA, USA.
+ Sabovcik, Frantisek. Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
+ Perelman, Dalia. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
+ Contrepois, Kevin. Stanford Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, CA, USA.
+ Contrepois, Kevin. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
+ Li, Xiao. Department of Biochemistry, The Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
+ Li, Xiao. Department of Computer and Data Sciences, Case Western Reserve University, Cleveland, OH, USA.
+ Snyder, Michael P. Stanford Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, CA, USA.
+ Snyder, Michael P. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
+ Snyder, Michael P. Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
+ Nadeau, Kari C. Sean N Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA.
+ Nadeau, Kari C. Department of Medicine, Stanford University, Stanford, CA, USA.
+ Kuznetsova, Tatiana. Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
+ Haddad, Francois. Stanford Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, CA, USA.
+ Gardner, Christopher D. Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
+ Gardner, Christopher D. Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, CA, USA.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adult
+ *Angiotensin-Converting Enzyme 2/me [Metabolism]
+ Biomarkers/bl [Blood]
+ *Body Composition
+ Body Mass Index
+ *COVID-19/me [Metabolism]
+ Cholesterol, HDL/bl [Blood]
+ Cholesterol, LDL/bl [Blood]
+ *Diet, Reducing
+ Female
+ Humans
+ Inflammation
+ Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/dh [Diet Therapy]
+ *Obesity/me [Metabolism]
+ Oxidative Stress
+ Pandemics
+ *Proteome/me [Metabolism]
+ SARS-CoV-2
+ Triglycerides/bl [Blood]
+ *Weight Loss/ph [Physiology]
+ Weight Reduction Programs
+Keyword Heading
+ angiotensin-converting enzyme 2
+ body composition
+ metabolic health
+ proteomics
+ weight loss diet intervention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) serves protective functions in metabolic, cardiovascular, renal, and pulmonary diseases and is linked to COVID-19 pathology. The correlates of temporal changes in soluble ACE2 (sACE2) remain understudied.
+
+ OBJECTIVES: We explored the associations of sACE2 with metabolic health and proteome dynamics during a weight loss diet intervention.
+
+ METHODS: We analyzed 457 healthy individuals (mean +/- SD age: 39.8 +/- 6.6 y) with BMI 28-40 kg/m2 in the DIETFITS (Diet Intervention Examining the Factors Interacting with Treatment Success) study. Biochemical markers of metabolic health and 236 proteins were measured by Olink CVDII, CVDIII, and Inflammation I arrays at baseline and at 6 mo during the dietary intervention. We determined clinical and routine biochemical correlates of the diet-induced change in sACE2 (DELTAsACE2) using stepwise linear regression. We combined feature selection models and multivariable-adjusted linear regression to identify protein dynamics associated with DELTAsACE2.
+
+ RESULTS: sACE2 decreased on average at 6 mo during the diet intervention. Stronger decline in sACE2 during the diet intervention was independently associated with female sex, lower HOMA-IR and LDL cholesterol at baseline, and a stronger decline in HOMA-IR, triglycerides, HDL cholesterol, and fat mass. Participants with decreasing HOMA-IR (OR: 1.97; 95% CI: 1.28, 3.03) and triglycerides (OR: 2.71; 95% CI: 1.72, 4.26) had significantly higher odds for a decrease in sACE2 during the diet intervention than those without (P <= 0.0073). Feature selection models linked DELTAsACE2 to changes in alpha-1-microglobulin/bikunin precursor, E-selectin, hydroxyacid oxidase 1, kidney injury molecule 1, tyrosine-protein kinase Mer, placental growth factor, thrombomodulin, and TNF receptor superfamily member 10B. DELTAsACE2 remained associated with these protein changes in multivariable-adjusted linear regression.
+
+ CONCLUSIONS: Decrease in sACE2 during a weight loss diet intervention was associated with improvements in metabolic health, fat mass, and markers of angiotensin peptide metabolism, hepatic and vascular injury, renal function, chronic inflammation, and oxidative stress. Our findings may improve the risk stratification, prevention, and management of cardiometabolic complications. This trial was registered at clinicaltrials.gov as NCT01826591. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Proteome). 0 (Triglycerides). EC 3-4-17-23 (Angiotensin-Converting Enzyme 2).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1093%2fajcn%2fnqab243
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cauwenberghs&issn=0002-9165&title=American+Journal+of+Clinical+Nutrition&atitle=Temporal+changes+in+soluble+angiotensin-converting+enzyme+2+associated+with+metabolic+health%2C+body+composition%2C+and+proteome+dynamics+during+a+weight+loss+diet+intervention%3A+a+randomized+trial+with+implications+for+the+COVID-19+pandemic.&volume=114&issue=5&spage=1655&epage=1665&date=2021&doi=10.1093%2Fajcn%2Fnqab243&pmid=34375388&sid=OVID:medline
+
+<674>
+Unique Identifier
+ 34677749
+Title
+ HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution. [Review]
+Source
+ Cell Stress & Chaperones. 26(6):889-915, 2021 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Costa-Beber LC; Heck TG; Fiorin PBG; Ludwig MS
+Author NameID
+ Costa-Beber, Lilian Correa; ORCID: http://orcid.org/0000-0001-7796-1641
+Authors Full Name
+ Costa-Beber, Lilian Correa; Heck, Thiago Gomes; Fiorin, Pauline Brendler Goettems; Ludwig, Mirna Stela.
+Institution
+ Costa-Beber, Lilian Correa. Research Group in Physiology, Postgraduate Program in Integral Attention to Health, Department of Life Sciences, Regional University of Northwestern State's Rio Grande do Sul (UNIJUI), Rua do Comercio, 3000 - Bairro Universitario -, Ijui, RS, 98700-000, Brazil. lilian.beber@sou.unijui.edu.br.
+ Costa-Beber, Lilian Correa. Postgraduation Program in Integral Attention to Health (PPGAIS-UNIJUI/UNICRUZ), Ijui, RS, Brazil. lilian.beber@sou.unijui.edu.br.
+ Heck, Thiago Gomes. Research Group in Physiology, Postgraduate Program in Integral Attention to Health, Department of Life Sciences, Regional University of Northwestern State's Rio Grande do Sul (UNIJUI), Rua do Comercio, 3000 - Bairro Universitario -, Ijui, RS, 98700-000, Brazil.
+ Heck, Thiago Gomes. Postgraduation Program in Integral Attention to Health (PPGAIS-UNIJUI/UNICRUZ), Ijui, RS, Brazil.
+ Fiorin, Pauline Brendler Goettems. Research Group in Physiology, Postgraduate Program in Integral Attention to Health, Department of Life Sciences, Regional University of Northwestern State's Rio Grande do Sul (UNIJUI), Rua do Comercio, 3000 - Bairro Universitario -, Ijui, RS, 98700-000, Brazil.
+ Ludwig, Mirna Stela. Research Group in Physiology, Postgraduate Program in Integral Attention to Health, Department of Life Sciences, Regional University of Northwestern State's Rio Grande do Sul (UNIJUI), Rua do Comercio, 3000 - Bairro Universitario -, Ijui, RS, 98700-000, Brazil.
+ Ludwig, Mirna Stela. Postgraduation Program in Integral Attention to Health (PPGAIS-UNIJUI/UNICRUZ), Ijui, RS, Brazil.
+MeSH Subject Headings
+ *Air Pollution/ae [Adverse Effects]
+ Biomarkers/bl [Blood]
+ Diabetes Complications/bl [Blood]
+ Diabetes Complications/co [Complications]
+ Diabetes Complications/th [Therapy]
+ *Exercise/ae [Adverse Effects]
+ *HSP70 Heat-Shock Proteins/bl [Blood]
+ Heat-Shock Response/de [Drug Effects]
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/ci [Chemically Induced]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Oxidative Stress/de [Drug Effects]
+Keyword Heading
+ Diabetes
+ Exercise
+ Fatigue
+ Fine particulate matter
+ Heat shock response
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Physical exercise has acute and chronic effects on inflammatory balance, metabolic regulation, and redox status. Exercise-induced adaptations are mediated by enhanced 70-kDa heat shock protein (HSP70) levels and an improved heat shock response (HSR). Therefore, exercise could be useful against disease conditions [obesity, diabetes mellitus (DM), and exposure to atmospheric pollutants] marked by an impaired HSR. However, exercise performed by obese or diabetic subjects under pollution conditions might also be dangerous at certain intensities. Intensity correlates with an increase in HSP70 levels during physical exercise until a critical point at which the effort becomes harmful and impairs the HSR. Establishing a unique biomarker able to indicate the exercise intensity on metabolism and cellular fatigue is essential to ensure adequate and safe exercise recommendations for individuals with obesity or DM who require exercise to improve their metabolic status and live in polluted regions. In this review, we examined the available evidence supporting our hypothesis that HSP70 could serve as a biomarker for determining the optimal exercise intensity for subjects with obesity or diabetes when exposed to air pollution and establishing the fine threshold between anti-inflammatory and pro-inflammatory exercise effects. Copyright © 2021. Cell Stress Society International.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (HSP70 Heat-Shock Proteins).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs12192-021-01241-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Costa-Beber&issn=1355-8145&title=Cell+Stress+%26+Chaperones&atitle=HSP70+as+a+biomarker+of+the+thin+threshold+between+benefit+and+injury+due+to+physical+exercise+when+exposed+to+air+pollution.&volume=26&issue=6&spage=889&epage=915&date=2021&doi=10.1007%2Fs12192-021-01241-1&pmid=34677749&sid=OVID:medline
+
+<675>
+Unique Identifier
+ 34166960
+Title
+ Functional significance of 8-isoprostanes in sinonasal disease and asthma.
+Source
+ Respiratory Medicine. 185:106506, 2021 Aug-Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Duchene B; Caffry S; Kaminsky DA; Que LG; Poynter ME; Dixon AE
+Authors Full Name
+ Duchene, Brittany; Caffry, Sarah; Kaminsky, David A; Que, Loretta G; Poynter, Matthew E; Dixon, Anne E.
+Institution
+ Duchene, Brittany. Larner College of Medicine, University of Vermont, Burlington, VT, USA.
+ Caffry, Sarah. Larner College of Medicine, University of Vermont, Burlington, VT, USA.
+ Kaminsky, David A. Larner College of Medicine, University of Vermont, Burlington, VT, USA.
+ Que, Loretta G. Duke University School of Medicine, Durham, NC, USA.
+ Poynter, Matthew E. Larner College of Medicine, University of Vermont, Burlington, VT, USA.
+ Dixon, Anne E. Larner College of Medicine, University of Vermont, Burlington, VT, USA. Electronic address: anne.dixon@uvmhealth.org.
+MeSH Subject Headings
+ Adult
+ *Asthma/di [Diagnosis]
+ Asthma/et [Etiology]
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ *Dinoprost/aa [Analogs & Derivatives]
+ Dinoprost/an [Analysis]
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Nasal Lavage Fluid/ch [Chemistry]
+ Obesity/me [Metabolism]
+ *Oxidative Stress
+ *Paranasal Sinus Diseases/di [Diagnosis]
+ Paranasal Sinus Diseases/et [Etiology]
+ Racial Groups
+ Young Adult
+Keyword Heading
+ Obesity
+ Oxidative stress
+ Race
+ Reactive oxygen species
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The purpose of this study was to investigate how 8-isoprostanes, used as a marker of airway oxidative stress, were related to sinus disease and asthma.
+
+ METHODS: We analyzed samples and data from two separate studies, one investigating sinonasal disease in asthma, the other investigating the effect of BMI on airway disease. We measured airway (nasal lavage) 8-isoprostanes and investigated the relationship with measures of sinus and asthma symptoms, asthma control and lung function.
+
+ RESULTS: The study of people with sinonasal disease and poorly controlled asthma included 48 obese, 31 overweight and 23 lean participants. In multivariate analysis, nasal lavage 8-isoprostane levels increased with increasing BMI (p < 0.01), and were higher in Caucasian than African American participants (p = 0.01). Sinus symptoms were inversely related to nasal 8-isoprostanes (p = 0.02) independent of BMI and Race. In the study investigating the effect of BMI on airway disease, we enrolled 13 controls with obesity and 21 people with obesity and asthma: 8-isoprostane levels were higher in obese controls than in obese people with asthma (p < 0.01), and levels were inversely related to sinus symptoms (p = 0.02) and asthma control (p < 0.01).
+
+ INTERPRETATION: 8-isoprostanes in nasal lavage are increased in obesity, and increased in Caucasians compared with African Americans. However, levels are higher in obese controls than obese people with asthma, and appear inversely related to symptoms of airway disease.
+
+ CLINICAL IMPLICATION: Airway 8-isoprostanes likely reflect complex oxidative signaling pathways, which are altered in obesity and those of different race, rather than being a simple marker of airway oxidative injury.
+
+ CAPSULE SUMMARY: Increased airway oxidative signaling (8-isoprostanes), may reflect normal physiology in the setting of obesity, as decreased levels are associated with disease activity in people with chronic sinonasal disease and asthma. Copyright © 2021 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 27415-26-5 (8-epi-prostaglandin F2alpha). B7IN85G1HY (Dinoprost).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.rmed.2021.106506
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Duchene&issn=0954-6111&title=Respiratory+Medicine&atitle=Functional+significance+of+8-isoprostanes+in+sinonasal+disease+and+asthma.&volume=185&issue=&spage=106506&epage=&date=2021&doi=10.1016%2Fj.rmed.2021.106506&pmid=34166960&sid=OVID:medline
+
+<676>
+Unique Identifier
+ 34528871
+Title
+ The Assessment of Some Metabolic Markers by Combination of Ursolic Acid Supplementation and Resistance Training in Young Older Obese Women.
+Source
+ Endocrine, Metabolic & Immune Disorders Drug Targets. 21(10):1912-1919, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Asghari E; Hosseini SRA; Kiania M; Farkhondeh T; Arazi H; Samarghandian S
+Authors Full Name
+ Asghari, Ehsan; Hosseini, Seyyed Reza Attarzadeh; Kiania, Mina; Farkhondeh, Tahereh; Arazi, Hamid; Samarghandian, Saeed.
+Institution
+ Asghari, Ehsan. Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Iran.
+ Hosseini, Seyyed Reza Attarzadeh. Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Iran.
+ Kiania, Mina. Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Iran.
+ Farkhondeh, Tahereh. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran.
+ Arazi, Hamid. Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.
+ Samarghandian, Saeed. Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
+MeSH Subject Headings
+ Aged
+ Biomarkers/an [Analysis]
+ *Biomarkers/bl [Blood]
+ Combined Modality Therapy
+ Dietary Supplements
+ Energy Metabolism/de [Drug Effects]
+ Exercise/ph [Physiology]
+ Female
+ Fibronectins/bl [Blood]
+ Humans
+ Inflammation Mediators/bl [Blood]
+ Insulin/bl [Blood]
+ Insulin Resistance/ph [Physiology]
+ Iran
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/th [Therapy]
+ Pilot Projects
+ Resistance Training/mt [Methods]
+ *Resistance Training
+ *Triterpenes/ad [Administration & Dosage]
+ Ursolic Acid
+Keyword Heading
+ Aging
+ BDNF
+ Irisin
+ Ursolic acid
+ cytokine
+ metabolic markers
+ resistance training.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In this study, we explored the impacts of moderate-to-high intensity resistance circuit training (MHRCT) and Ursolic acid (UA) supplementation to improve these pathological changes in young older obese women (women between the ages of 50 and 70).
+
+ METHODS: The study included twenty-five young older women (age > 50 years and <=70 years) with stage I-II obesity (BMI >= 30 and <40 kg/m2), who received eight weeks placebo with MHRCT, and MHRCT with UA supplementation. UA or placebo orally was ingested as a capsule three times per day for eight weeks. The following parameters were evaluated post- and pre-intervention. Data were analyzed using ANOVA with repeated measures.
+
+ RESULTS: Interleukin-15 (IL-15), Interleukin-6 (IL-6), Insulin, and HOMA-IR decreased significantly in the placebo and UA groups versus control, but the UA group significantly decreased compared with the placebo (p<0.05). In turn, the Brain-Derived Neurotrophic Factor (BDNF) and Irisin levels showed a significant increase in the placebo and UA groups versus control. However, the BDNF in the UA group significantly increased compared with the placebo (p < 0.05).
+
+ CONCLUSION: We demonstrated that applying resistance training can reverse the pathological changes that may occur with aging and a sedentary lifestyle. Our results showed that UA could enhance the effects of this type of exercise. Therefore, a combination of the resistance training program and UA supplementation may be considered as a novel and influential intervention to metabolic derangements and may also decrease the burden associated with this condition. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FNDC5 protein, human). 0 (Fibronectins). 0 (Inflammation Mediators). 0 (Insulin). 0 (Triterpenes).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.2174%2f1871530320666201208105844
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Asghari&issn=1871-5303&title=Endocrine%2C+Metabolic+%26+Immune+Disorders+Drug+Targets&atitle=The+Assessment+of+Some+Metabolic+Markers+by+Combination+of+Ursolic+Acid+Supplementation+and+Resistance+Training+in+Young+Older+Obese+Women.&volume=21&issue=10&spage=1912&epage=1919&date=2021&doi=10.2174%2F1871530320666201208105844&pmid=34528871&sid=OVID:medline
+
+<677>
+Unique Identifier
+ 31340393
+Title
+ Circulating Serum Myonectin Levels in Obesity and Type 2 Diabetes Mellitus.
+Source
+ Experimental & Clinical Endocrinology & Diabetes. 129(7):528-534, 2021 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li Z; Yang YL; Zhu YJ; Li CG; Tang YZ; Ni CL; Chen LM; Niu WY
+Authors Full Name
+ Li, Zhu; Yang, Yan-Ling; Zhu, Yan-Juan; Li, Chen-Guang; Tang, Yun-Zhao; Ni, Chang-Lin; Chen, Li-Ming; Niu, Wen-Yan.
+Institution
+ Li, Zhu. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
+ Yang, Yan-Ling. Tianjin University of Traditional Chinese Medicine, Tianjin, China.
+ Zhu, Yan-Juan. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
+ Li, Chen-Guang. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
+ Tang, Yun-Zhao. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
+ Ni, Chang-Lin. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
+ Chen, Li-Ming. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
+ Niu, Wen-Yan. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
+ Niu, Wen-Yan. Department of Immunology, Key Laboratory of Immuno Microenvironment and Disease of the Educational Ministry of China, Tianjin Medical University, Tianjin, China.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Collagen/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+Abstract
+ OBJECTIVE: Myonectin is one of the myokines and has gained interest as a potential new strategy to combat obesity and its associated disorders, such as type 2 diabetes mellitus (T2DM). The objective of this study was to investigate circulating serum myonectin levels in nondiabetes and T2DM and elucidate possible relationships between serum myonectin levels and metabolic parameters in patients with T2DM.
+
+ DESIGN: A total of 362 Chinese patients with T2DM and 100 age- and sex-matched healthy controls were recruited in this study. Clinical characteristics, blood biochemistry, and circulating myonectin levels were measured by enzyme-linked immunosorbent assay.
+
+ RESULTS: Circulating myonectin levels were significantly decreased in T2DM compared with controls. Obese nondiabetic controls had significantly lower serum myonectin levels compared with lean nondiabetic controls. In diabetic patients, serum myonectin concentrations were significantly negatively correlated with body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), hemoglobin A1c (HbA1c), fasting insulin (Fins), the homeostatic model assessment of insulin resistance (HOMA-IR), visceral fat area, and subcutaneous fat area. After adjusting for covariates, multivariate stepwise regression analysis demonstrated that BMI, LDL-C, TG, HOMA-IR, and visceral fat were the main independent predictors of low serum myonectin concentrations.
+
+ CONCLUSIONS: Circulating myonectin levels were decreased in T2DM patients and in obese subjects. Moreover, serum myonectin levels were correlated with metabolic markers of T2DM. These data suggest that myonectin may be a useful marker in predicting the development of obesity and T2DM. Copyright Thieme. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C1QTNF5 protein, human). 9007-34-5 (Collagen).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1055%2fa-0896-8548
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=0947-7349&title=Experimental+%26+Clinical+Endocrinology+%26+Diabetes&atitle=Circulating+Serum+Myonectin+Levels+in+Obesity+and+Type+2+Diabetes+Mellitus.&volume=129&issue=7&spage=528&epage=534&date=2021&doi=10.1055%2Fa-0896-8548&pmid=31340393&sid=OVID:medline
+
+<678>
+Unique Identifier
+ 36286672
+Title
+ [The importance of matrix metalloproteinases in the development of atrial fibrillation in obesity]. [Russian]
+Source
+ Terapevticheskii Arkhiv. 93(12):1451-1456, 2021 Dec 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Podzolkov VI; Tarzimanova AI; Bragina AE; Gataulin RG; Oganesyan KA; Pokrovskaya AE; Osadchy KK
+Author NameID
+ Podzolkov, V I; ORCID: https://orcid.org/0000-0002-0758-5609
+ Tarzimanova, A I; ORCID: https://orcid.org/0000-0001-9536-8307
+ Bragina, A E; ORCID: https://orcid.org/0000-0002-2699-1610
+ Gataulin, R G; ORCID: https://orcid.org/0000-0002-8782-0380
+ Oganesyan, K A; ORCID: https://orcid.org/0000-0003-3580-7229
+ Pokrovskaya, A E; ORCID: https://orcid.org/0000-0002-8875-9032
+ Osadchy, K K; ORCID: https://orcid.org/0000-0001-8202-4492
+Authors Full Name
+ Podzolkov, V I; Tarzimanova, A I; Bragina, A E; Gataulin, R G; Oganesyan, K A; Pokrovskaya, A E; Osadchy, K K.
+Institution
+ Podzolkov, V I. Sechenov First Moscow State Medical University (Sechenov University).
+ Tarzimanova, A I. Sechenov First Moscow State Medical University (Sechenov University).
+ Bragina, A E. Sechenov First Moscow State Medical University (Sechenov University).
+ Gataulin, R G. Sechenov First Moscow State Medical University (Sechenov University).
+ Oganesyan, K A. Sechenov First Moscow State Medical University (Sechenov University).
+ Pokrovskaya, A E. Sechenov First Moscow State Medical University (Sechenov University).
+ Osadchy, K K. Sechenov First Moscow State Medical University (Sechenov University).
+MeSH Subject Headings
+ Humans
+ Atrial Fibrillation/di [Diagnosis]
+ Atrial Fibrillation/et [Etiology]
+ *Atrial Fibrillation
+ Matrix Metalloproteinase 9
+ Tissue Inhibitor of Metalloproteinase-1
+ Matrix Metalloproteinases
+ Biomarkers
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+Keyword Heading
+ atrial fibrillation
+ matrix metalloproteinases
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: One of the trends in modern cardiology is the study of the matrix metalloproteinase (MMP) system. Currently, an increase in plasma concentrations of some MMPs and their tissue inhibitors is considered as one of the earliest biochemical markers of myocardial fibrosis in various diseases of the cardiovascular system. Discusses the importance of MMP in the development of atrial fibrillation (AF).
+
+ AIM: To study the effect of the MMP system on the development of AF in obese patients.
+
+ MATERIALS AND METHODS: The study included 105 patients with a body mass index of more than 30 kg/m2. Depending on the presence of AF, the patients were divided into 2 groups. The criterion for inclusion of patients in group 1 was the presence of documented AF paroxysm in 55 obese patients. The comparison group (group 2) consisted of 50 obese patients without heart rhythm disorders. When patients were included in the study, in order to assess the severity of visceral obesity, all patients underwent a general clinical examination, echocardiography. To determine the activity of the MMP system, venous blood was taken from patients.
+
+ RESULTS: Significantly higher values of MMP-9 were detected in patients with obesity and paroxysmal AF 315.753.4 ng/ml than in patients with obesity without heart rhythm disorders 220.954.7 ng/ml (p=0.002); the values of tissue inhibitor of metalloproteinase 1 were 185.342.2 and 119.242.6 ng/ml, respectively (p=0.007). In patients with obesity and paroxysmal AF, a correlation of moderate strength between the level of MMP-9 and the volume of left atrium and a direct dependence of moderate strength between the ratio of waist volume to height and the plasma values of MMP-9 was revealed. The MMP-9 index (AUC 0.92) had a high diagnostic value for determining the probability of having a paroxysmal form of AF in obese patients. With an increase in the level of MMP-9 more than 295 ng/ml, it is possible to predict the presence of paroxysmal AF in obese patients with a sensitivity of 74.5% and a specificity of 94%.
+
+ CONCLUSION: In patients with obesity and paroxysmal AF, a significant increase in the parameters of the MMP system (MMP-9 and tissue inhibitor of metalloproteinase 1) was revealed when compared with obese patients without heart rhythm disorders (p0.05). With an increase in MMP-9 of more than 285 ng/ml in obese patients, the appearance of AF with a sensitivity of 74.5% and a specificity of 94% can be predicted.
+Other Abstract
+ Publisher
+ O ocHoBaH e. O H M 3 TpeH oB coBpeMeHHo kap o o B eTc 3y eH e c cTeMbl MaTp kcHblx MeTa o poTe Ha3 (MM ). B HacTo ee BpeM oBbl eH e a3MeHHblx koH eHTpa HekoTopblx MM x TkaHeBblx H TopoB paccMaTp Ba T kak o H 3 Ha o ee paHH x ox M eck x MapkepoB po3a M okap a p pa3Hblx 3a o eBaH x cep e Ho-cocy cTo c cTeMbl. O cy aeTc 3Ha eH e MM B pa3B T p pe cep ( ). e b. 3y Tb B H e c cTeMbl MM Ha pa3B T e y o bHblx c o peH eM. MaTep a bl MeTo bl. B cc e oBaH e Bk eHbl 105 a eHToB c H ekcoM Maccbl Te a o ee 30 k /M2. B 3aB c MocT oT Ha o bHble pa3 e eHbl Ha 2 py bl. Kp Tep eM Bk eH a eHToB B 1- py y bl o Ha e y 55 o bHblx c o peH eM okyMeHT poBaHHo o apokc 3Ma . py y cpaBHeH (2- py a) cocTaB 50 a eHToB c o peH eM e3 Hapy eH cep e Ho o p TMa. p Bk eH a eHToB B cc e oBaH e c e b o eHk Bblpa eHHocT B c epa bHo o o peH BceM o bHblM poBo cb o ee k H eckoe o c e oBaH e, xokap o pa . o pe e eH akT BHocT c cTeMbl MM a eHTaM Bbl o H c 3a op BeHo3Ho kpoB . Pe3y bTaTbl. ocToBepHo o ee Bblcok e 3Ha eH MM 9- o T a (MM -9) Bbl B eHbl y a eHToB c o peH eM apokc 3Ma bHo opMo 315,753,4 H /M , eM y o bHblx c o peH eM e3 Hapy eH cep e Ho o p TMa 220,954,7 H /M (p=0,002); 3Ha eH TkaHeBo o H Topa MeTa o poTe Ha3 1- o T a cocTaB 185,342,2 119,242,6 H /M cooTBeTcTBeHHo (p=0,007). Y o bHblx c o peH eM apokc 3Ma bHo opMo Bbl B eHbl koppe oHHa 3aB c MocTb yMepeHHo c bl Me y ypoBHeM MM -9 o eMoM eBo o pe cep p Ma 3aB c MocTb yMepeHHo c bl Me y cooTHo eH eM o eMa Ta k pocTy a3MeHHblM 3Ha eH M MM -9. Bblcoko a HocT ecko eHHocTb o pe e eH Bepo THocT Ha apokc 3Ma bHo opMbl y a eHToB c o peH eM o a a oka3aTe b MM -9 (AUC 0,92). p yBe eH ypoBH MM -9 o ee 295 H /M Mo Ho c yBcTB Te bHocTb 74,5% c e HocTb 94% po Ho3 poBaTb Ha e apokc 3Ma bHo opMbl y o bHblx c o peH eM. ak eH e. Y a eHToB c o peH eM apokc 3Ma bHo opMo Bbl B eHo ocToBepHoe yBe eH e oka3aTe e c cTeMbl MM (MM -9 TkaHeBo o H Topa MeTa o poTe Ha3 1- o T a) p cpaBHeH c Ty HblM o bHblM e3 Hapy eH cep e Ho o p TMa (p0,05). p yBe eH MM -9 o ee 285 H /M y o bHblx c o peH eM Mo Ho po Ho3 poBaTb o B eH e c yBcTB Te bHocTb 74,5% c e HocTb 94%.
+ Language: Russian
+Registry Number/Name of Substance
+ EC 3-4-24-35 (Matrix Metalloproteinase 9). 0 (Tissue Inhibitor of Metalloproteinase-1). EC 3-4-24 (Matrix Metalloproteinases). 0 (Biomarkers).
+Publication Type
+ English Abstract. Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.26442%2f00403660.2021.12.201178
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Podzolkov&issn=0040-3660&title=Terapevticheskii+Arkhiv&atitle=%5BThe+importance+of+matrix+metalloproteinases+in+the+development+of+atrial+fibrillation+in+obesity%5D.&volume=93&issue=12&spage=1451&epage=1456&date=2021&doi=10.26442%2F00403660.2021.12.201178&pmid=36286672&sid=OVID:medline
+
+<679>
+Unique Identifier
+ 35735317
+Title
+ [Features of patients admitted for COVID-19 at a regional hospital in the Chilean Araucania Region]. [Spanish]
+Original Title
+ Caracteristicas clinicas de pacientes ingresados por COVID-19 en un Hospital de alta complejidad de la region de la Araucania-Chile.
+Source
+ Revista Medica de Chile. 149(11):1552-1560, 2021 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Balboa-Castillo T; Ossa X; Munoz S; Neira J; Padilla A; Onat M; Briones J; Concha C
+Authors Full Name
+ Balboa-Castillo, Teresa; Ossa, Ximena; Munoz, Sergio; Neira, Jaime; Padilla, Arturo; Onat, Mario; Briones, Javier; Concha, Carla.
+Institution
+ Balboa-Castillo, Teresa. Departamento de Salud Publica, Universidad de La Frontera, Temuco, Chile.
+ Ossa, Ximena. Departamento de Salud Publica, Universidad de La Frontera, Temuco, Chile.
+ Munoz, Sergio. Departamento de Salud Publica, Universidad de La Frontera, Temuco, Chile.
+ Neira, Jaime. Departamento de Salud Publica, Universidad de La Frontera, Temuco, Chile.
+ Padilla, Arturo. Departamento de Ingenieria Mecanica, Universidad de La Frontera, Temuco, Chile.
+ Onat, Mario. Hospital Hernan Henriquez Aravena, Temuco, Chile.
+ Briones, Javier. Hospital Hernan Henriquez Aravena, Temuco, Chile.
+ Concha, Carla. Hospital Hernan Henriquez Aravena, Temuco, Chile.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ COVID-19/ep [Epidemiology]
+ *COVID-19
+ Chile/ep [Epidemiology]
+ Comorbidity
+ Cough/co [Complications]
+ Dyspnea/ep [Epidemiology]
+ Dyspnea/et [Etiology]
+ Female
+ Fever/co [Complications]
+ Fever/ep [Epidemiology]
+ Hospitalization
+ Hospitals
+ Humans
+ Hypertension/co [Complications]
+ Hypertension/ep [Epidemiology]
+ *Hypertension
+ Male
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Retrospective Studies
+ SARS-CoV-2
+Abstract
+ BACKGROUND: The Araucania region in Chile had the greatest COVID-19 incidence and lethality in Chile Aim: To describe the clinical characteristics and evolution of patients admitted for COVID-19 in a high complexity Hospital in the region of La Araucania-Chile.
+
+ MATERIAL AND METHODS: Review of medical records of the first 169 patients aged 55 +/- 17 years (50% women) admitted for COVID-19 between march and may, 2020 at a regional hospital in Temuco Chile.
+
+ RESULTS: The most common comorbidities of these patients were hypertension, diabetes, and obesity. The symptom triad of cough, dyspnea and fever was present in 85%. Less frequent symptoms were diarrhea and vomiting. Biomarkers at admission such as ferritin, D-dimer, among others, were significantly higher among patients who required admission to the Intensive Care Unit. The presence of cough, dyspnea and fever were significantly associated with longer hospitalization time and requirement for mechanical ventilation. Hypertension and obesity were significantly associated with longer hospitalization stay. Eight percent of patients died.
+
+ CONCLUSIONS: Symptoms such as cough, dyspnea and fever and specific biomarkers on admission were associated with a worse evolution of adult inpatients with COVID-19.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.4067%2fS0034-98872021001101552
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Balboa-Castillo&issn=0034-9887&title=Revista+Medica+de+Chile&atitle=Caracteristicas+clinicas+de+pacientes+ingresados+por+COVID-19+en+un+Hospital+de+alta+complejidad+de+la+region+de+la+Araucania-Chile.&volume=149&issue=11&spage=1552&epage=1560&date=2021&doi=10.4067%2FS0034-98872021001101552&pmid=35735317&sid=OVID:medline
+
+<680>
+Unique Identifier
+ 35111163
+Title
+ Leptin Promotes Greater Ki67 Expression in CD4+ T Cells From Obese Compared to Lean Persons Living With HIV.
+Source
+ Frontiers in Immunology. 12:796898, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fuseini H; Smith R; Nochowicz CH; Simmons JD; Hannah L; Wanjalla CN; Gabriel CL; Mashayekhi M; Bailin SS; Castilho JL; Hasty AH; Koethe JR; Kalams SA
+Authors Full Name
+ Fuseini, Hubaida; Smith, Rita; Nochowicz, Cindy H; Simmons, Joshua D; Hannah, LaToya; Wanjalla, Celestine N; Gabriel, Curtis L; Mashayekhi, Mona; Bailin, Samuel S; Castilho, Jessica L; Hasty, Alyssa H; Koethe, John R; Kalams, Spyros A.
+Institution
+ Fuseini, Hubaida. Divison of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Smith, Rita. Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Nochowicz, Cindy H. Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Simmons, Joshua D. Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Hannah, LaToya. Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Wanjalla, Celestine N. Divison of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Wanjalla, Celestine N. Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Gabriel, Curtis L. Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Gabriel, Curtis L. Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Mashayekhi, Mona. Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Bailin, Samuel S. Divison of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Castilho, Jessica L. Divison of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Hasty, Alyssa H. Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, United States.
+ Hasty, Alyssa H. The Veterans Affairs Tennessee Healthcare System, Nashville, TN, United States.
+ Koethe, John R. Divison of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Koethe, John R. Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Koethe, John R. The Veterans Affairs Tennessee Healthcare System, Nashville, TN, United States.
+ Kalams, Spyros A. Divison of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
+ Kalams, Spyros A. Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Mass Index
+ *CD4-Positive T-Lymphocytes/de [Drug Effects]
+ CD4-Positive T-Lymphocytes/im [Immunology]
+ *CD4-Positive T-Lymphocytes/me [Metabolism]
+ CD4-Positive T-Lymphocytes/vi [Virology]
+ Cytokines/me [Metabolism]
+ Female
+ Flow Cytometry
+ *Gene Expression
+ *HIV Infections/ge [Genetics]
+ HIV Infections/vi [Virology]
+ Humans
+ Ki-67 Antigen/ge [Genetics]
+ *Ki-67 Antigen/me [Metabolism]
+ *Leptin/pd [Pharmacology]
+ Leukocytes, Mononuclear/im [Immunology]
+ Leukocytes, Mononuclear/me [Metabolism]
+ Lymphocyte Activation
+ Lymphocyte Count
+ Male
+ Middle Aged
+ Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+Keyword Heading
+ CD4+ T cell
+ HIV
+ IL-17A
+ Ki67
+ body mass index
+ leptin
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ While antiretroviral therapy (ART) has proven effective in suppressing viremia and disease progression among people living with human immunodeficiency virus (HIV; PLWH), suboptimal CD4+ T cell reconstitution remains a major obstacle in nearly 30% of ART-treated individuals. Epidemiological studies demonstrate that obesity, or a body mass index (BMI) >= 30 kg/m2, is positively correlated with greater CD4+ T cell recovery in PLWH on ART. Leptin is a known immunomodulator that is produced in proportion to fat mass and is increased in obese individuals, including PLWH. We hypothesized that CD4+ T cells from obese PLWH have increased cell proliferation and cytokine production compared to cells from lean PLWH, potentially modulated by differential effects of leptin signaling. To test this hypothesis, peripheral blood mononuclear cells from obese and lean PLWH with long-term virologic suppression on the same ART regimen were pretreated with recombinant leptin and then stimulated with anti-CD3/CD28 or PMA/ionomycin to measure Ki67 expression, leptin receptor (LepR) surface expression and cytokine production. In the absence of leptin, Ki67 expression and IL-17A production were significantly higher in CD4+ T cells from obese compared to lean PLWH. However, LepR expression was significantly lower on CD4+ T cells from obese compared to lean PLWH. After leptin treatment, Ki67 expression was significantly increased in CD4+ T cells from obese PLWH compared to the lean participants. Leptin also increased IL-17A production in CD4+ T cells from obese healthy controls. In contrast, leptin decreased IL-17A production in CD4+ T cells from both obese and lean PLWH. Combined, these results demonstrate that obesity is associated with greater CD4+ T cell proliferation among PLWH, and that higher circulating leptin levels in obesity may contribute to improved CD4+ T reconstitution in PLWH initiating ART. Copyright © 2022 Fuseini, Smith, Nochowicz, Simmons, Hannah, Wanjalla, Gabriel, Mashayekhi, Bailin, Castilho, Hasty, Koethe and Kalams.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Ki-67 Antigen). 0 (Leptin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffimmu.2021.796898
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fuseini&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Leptin+Promotes+Greater+Ki67+Expression+in+CD4%2B+T+Cells+From+Obese+Compared+to+Lean+Persons+Living+With+HIV.&volume=12&issue=&spage=796898&epage=&date=2021&doi=10.3389%2Ffimmu.2021.796898&pmid=35111163&sid=OVID:medline
+
+<681>
+Unique Identifier
+ 35078309
+Title
+ Serum visfatin as a metabolic biomarker in obese patients with gestational diabetes mellitus.
+Source
+ Minerva Endocrinology. 46(4):396-405, 2021 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Radzicka-Mularczyk S; Zaborowski MP; Brazert J; Pietryga M
+Authors Full Name
+ Radzicka-Mularczyk, Sandra; Zaborowski, Mikolaj P; Brazert, Jacek; Pietryga, Marek.
+Institution
+ Radzicka-Mularczyk, Sandra. Division of Obstetrics and Women's Diseases, Department of Gynecology, Obstetrics and Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland - sandra.radzicka@gmail.com.
+ Zaborowski, Mikolaj P. Division of Gynecologic Oncology, Department of Gynecology, Obstetrics and Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland.
+ Brazert, Jacek. Division of Obstetrics and Women's Diseases, Department of Gynecology, Obstetrics and Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland.
+ Pietryga, Marek. Division of Obstetrics and Women's Diseases, Department of Gynecology, Obstetrics and Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland.
+MeSH Subject Headings
+ Biomarkers
+ Diabetes, Gestational/dt [Drug Therapy]
+ *Diabetes, Gestational
+ Female
+ Humans
+ Infant, Newborn
+ *Nicotinamide Phosphoribosyltransferase
+ Obesity
+ Pregnancy
+ Serum
+Abstract
+ BACKGROUND: Visfatin is an adipokine produced and secreted by the adipose tissue. It exerts an insulin-like effect by the insulin receptor-1 and has a hypoglycemic effect. We aimed to investigate how serum visfatin changes in women with gestational diabetes mellitus (GDM), and whether it is predictive of neonatal outcomes.
+
+ METHODS: Visfatin levels were prospectively measured in peripheral blood serum by enzyme immunoassay in 210 pregnant women, 156 of which were diagnosed with GDM, 18 of which suffered from pregnancy-induced hypertension (PIH) and 36 healthy controls.
+
+ RESULTS: Patients with obesity class II (median=2.562 ng/mL) and class III (median=6.2940 ng/mL) had higher serum visfatin than overweight patients (median=0.735 ng/mL); (Mann-Whitney U test, P=0.037 and P=0.023, respectively). In GDM patients with BMI above 30, serum visfatin was associated to glycosylated hemoglobin (Spearman correlation test, R=0.26, P=0.045). Women with BMI above 25 treated with insulin had lower serum visfatin levels than those treated with diet only (Mann-Whitney U test, P=0.045). No correlation was found between visfatin and parameters of lipid profile such as HDL, LDL, or triglycerides (Spearman correlation tests, R=-0.051, -0.1, 0.0019; P=0.54, 0.29, 0.98, respectively). We observed that visfatin was not associated with birth weight (Spearman correlation test, R=-0.014, P=0.86) or adverse neonatal outcome as measured by umbilical artery pH below 7.25 (Mann-Whitney U test, P=0.55) or Apgar score below 10 (Mann-Whitney U test, P=0.21).
+
+ CONCLUSIONS: In GDM patients with higher BMI, serum visfatin was elevated, correlated positively with glycosylated hemoglobin, and decreased upon treatment with insulin therapy.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.23736%2fS2724-6507.20.03280-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Radzicka-Mularczyk&issn=2724-6116&title=Minerva+Endocrinology&atitle=Serum+visfatin+as+a+metabolic+biomarker+in+obese+patients+with+gestational+diabetes+mellitus.&volume=46&issue=4&spage=396&epage=405&date=2021&doi=10.23736%2FS2724-6507.20.03280-0&pmid=35078309&sid=OVID:medline
+
+<682>
+Unique Identifier
+ 35069589
+Title
+ Obesity Increases Gene Expression of Markers Associated With Immunosenescence in Obese Middle-Aged Individuals.
+Source
+ Frontiers in Immunology. 12:806400, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Brunelli DT; Boldrini VO; Bonfante ILP; Duft RG; Mateus K; Costa L; Chacon-Mikahil MPT; Teixeira AM; Farias AS; Cavaglieri CR
+Authors Full Name
+ Brunelli, Diego T; Boldrini, Vinicius O; Bonfante, Ivan L P; Duft, Renata G; Mateus, Keryma; Costa, Leonardo; Chacon-Mikahil, Mara P T; Teixeira, Ana M; Farias, Alessandro S; Cavaglieri, Claudia R.
+Institution
+ Brunelli, Diego T. Exercise Physiology Lab (FISEX) - Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, Brazil.
+ Boldrini, Vinicius O. Autoimmune Research Lab, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
+ Bonfante, Ivan L P. Exercise Physiology Lab (FISEX) - Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, Brazil.
+ Duft, Renata G. Exercise Physiology Lab (FISEX) - Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, Brazil.
+ Mateus, Keryma. Exercise Physiology Lab (FISEX) - Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, Brazil.
+ Costa, Leonardo. Exercise Physiology Lab (FISEX) - Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, Brazil.
+ Chacon-Mikahil, Mara P T. Exercise Physiology Lab (FISEX) - Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, Brazil.
+ Teixeira, Ana M. Research Center for Sports Sciences and Physical Activity, University of Coimbra, Coimbra, Portugal.
+ Farias, Alessandro S. Autoimmune Research Lab, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
+ Cavaglieri, Claudia R. Exercise Physiology Lab (FISEX) - Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, Brazil.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adult
+ Age Factors
+ Aging
+ *Biomarkers
+ Body Composition
+ Body Mass Index
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ *Gene Expression
+ Humans
+ *Immunosenescence/ge [Genetics]
+ Male
+ Middle Aged
+ *Obesity/ge [Genetics]
+ *Obesity/im [Immunology]
+ Obesity/me [Metabolism]
+Keyword Heading
+ adipose tissue
+ aging
+ inflammation
+ physical fitness
+ type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Recently, it has been argued that obesity leads to a chronic pro-inflammatory state that can accelerate immunosenescence, predisposing to the early acquisition of an immune risk profile and health problems related to immunity in adulthood. In this sense, the present study aimed to verify, in circulating leukocytes, the gene expression of markers related to early immunosenescence associated with obesity and its possible relationships with the physical fitness in obese adults with type 2 diabetes or without associated comorbidities. The sample consisted of middle-aged obese individuals (body mass index (BMI) between 30-35 kg/m2) with type 2 diabetes mellitus (OBD; n = 17) or without associated comorbidity (OB; n = 18), and a control group of eutrophic healthy individuals (BMI: 20 - 25 kg/m2) of same ages (E; n = 18). All groups (OBD, OB and E) performed the functional analyses [muscle strength (1RM) and cardiorespiratory fitness (VO2max)], anthropometry, body composition (Air Displacement Plethysmograph), blood collections for biochemical (anti-CMV) and molecular (gene expression of leptin, IL-2, IL-4, IL-6, IL-10, TNF-alpha, PD-1, P16ink4a, CCR7, CD28 and CD27) analyses of markers related to immunosenescence. Increased gene expression of leptin, IL-2, IL-4, IL-10, TNF-alpha, PD-1, P16ink4a, CCR7 and CD27 was found for the OBD and OB groups compared to the E group. Moreover, VO2max for the OBD and OB groups was significantly lower compared to E. In conclusion, obesity, regardless of associated disease, induces increased gene expression of markers associated with inflammation and immunosenescence in circulating leukocytes in obese middle-aged individuals compared to a eutrophic group of the same age. Additionally, increased adipose tissue and markers of chronic inflammation and immunosenescence were associated to impairments in the cardiorespiratory capacity of obese middle-aged individuals. Copyright © 2022 Brunelli, Boldrini, Bonfante, Duft, Mateus, Costa, Chacon-Mikahil, Teixeira, Farias and Cavaglieri.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffimmu.2021.806400
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Brunelli&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Obesity+Increases+Gene+Expression+of+Markers+Associated+With+Immunosenescence+in+Obese+Middle-Aged+Individuals.&volume=12&issue=&spage=806400&epage=&date=2021&doi=10.3389%2Ffimmu.2021.806400&pmid=35069589&sid=OVID:medline
+
+<683>
+Unique Identifier
+ 35034889
+Title
+ REPORT-The phytochemical valuation and lipid profile impression with Zanthoxylum armatum (Rutaceae) through animal-model.
+Source
+ Pakistan Journal of Pharmaceutical Sciences. 34(6):2257-2264, 2021 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Munawar I; Ul Hassan SS; Abbas M; Ur Rehman MK; Ahmed H
+Authors Full Name
+ Munawar, Itique; Ul Hassan, Syed Saeed; Abbas, Muhammad; Ur Rehman, Muhammad Khalil; Ahmed, Hammed.
+Institution
+ Munawar, Itique. College of Pharmacy, University of the Punjab, Lahore, Pakistan.
+ Ul Hassan, Syed Saeed. Khauldonia College of Pharmacy, opp EME Society, Multan Road, Lahore, Pakistan.
+ Abbas, Muhammad. Mukabbir College of Pharmacy, Bhimber Road Gujrat, Pakistan.
+ Ur Rehman, Muhammad Khalil. College of Pharmacy, University of the Punjab, Lahore, Pakistan.
+ Ahmed, Hammed. Khauldonia College of Pharmacy, opp EME Society, Multan Road, Lahore, Pakistan / Department of Pharmacology, Sialkot Medical College, Sialkot, Pakistan.
+MeSH Subject Headings
+ Animals
+ Anti-Obesity Agents/ip [Isolation & Purification]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Diet, High-Fat
+ Disease Models, Animal
+ Lipids/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ *Obesity/pc [Prevention & Control]
+ Plant Components, Aerial
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ Rabbits
+ Weight Gain/de [Drug Effects]
+ Zanthoxylum/ch [Chemistry]
+ *Zanthoxylum
+Abstract
+ The exploration of promising anti-obesity influence of Zanthoxylum armatum (Rutaceae) is determined through our study of in-vitro and animal models. Obesity was induced in experimental albino rabbits by feeding highly fat diet (HFD) with regular feed for fortnight. The appraisal of anti-obesity of MZA and CZA extracts of leaves, fruit and stem of Z. armatum was performed in obese rabbits. Animals were divided into 04 groups. One group was categorized as control who received only HFD with no any extracts and drug. Other group was given orlistat orally a standard drug (10 mg/kg) in combination with the HFD regularly for 03 weeks and marked as positive control. Other 02 groups were allocated as experimental groups, 1st and 2nd experimental groups were administered daily 300 mg/kg of MZA and CMA extracts per oral route respectively for the same period. The substantial fall of lipid profile (total cholesterol, LDL, VLDL and TGs) and rise of HDL were perceived with methanolic extract on comparison to control groups. However, CMZ exhibited little response on serum lipid-profile. On conclusion, MZA extract of Z. armatum (areal parts) was considered a valid anti-obesity herbal remedy in experimental rabbits fed on high-feed diet.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Lipids). 0 (Plant Extracts).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&AN=35034889
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Munawar&issn=1011-601X&title=Pakistan+Journal+of+Pharmaceutical+Sciences&atitle=REPORT-The+phytochemical+valuation+and+lipid+profile+impression+with+Zanthoxylum+armatum+%28Rutaceae%29+through+animal-model.&volume=34&issue=6&spage=2257&epage=2264&date=2021&doi=&pmid=35034889&sid=OVID:medline
+
+<684>
+Unique Identifier
+ 35011021
+Title
+ Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients.
+Source
+ Nutrients. 14(1), 2021 Dec 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leyrolle Q; Cserjesi R; Demeure R; Neyrinck AM; Amadieu C; Rodriguez J; Karkkainen O; Hanhineva K; Paquot N; Cnop M; Cani PD; Thissen JP; Bindels LB; Klein O; Luminet O; Delzenne NM
+Author NameID
+ Neyrinck, Audrey M; ORCID: https://orcid.org/0000-0002-9435-3338
+ Karkkainen, Olli; ORCID: https://orcid.org/0000-0003-0825-4956
+ Cnop, Miriam; ORCID: https://orcid.org/0000-0002-5112-1692
+ Cani, Patrice D; ORCID: https://orcid.org/0000-0003-2040-2448
+ Bindels, Laure B; ORCID: https://orcid.org/0000-0003-3747-3234
+ Klein, Olivier; ORCID: https://orcid.org/0000-0003-2737-8049
+ Delzenne, Nathalie M; ORCID: https://orcid.org/0000-0003-2115-6082
+Authors Full Name
+ Leyrolle, Quentin; Cserjesi, Renata; Demeure, Romane; Neyrinck, Audrey M; Amadieu, Camille; Rodriguez, Julie; Karkkainen, Olli; Hanhineva, Kati; Paquot, Nicolas; Cnop, Miriam; Cani, Patrice D; Thissen, Jean-Paul; Bindels, Laure B; Klein, Olivier; Luminet, Olivier; Delzenne, Nathalie M.
+Institution
+ Leyrolle, Quentin. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium.
+ Cserjesi, Renata. Center for Social and Cultural Psychology, Universite Libre de Bruxelles, 1000 Brussels, Belgium.
+ Cserjesi, Renata. Institute of Psychology, Eotvos Lorand University, 1053 Budapest, Hungary.
+ Demeure, Romane. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium.
+ Neyrinck, Audrey M. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium.
+ Amadieu, Camille. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium.
+ Rodriguez, Julie. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium.
+ Karkkainen, Olli. School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland.
+ Hanhineva, Kati. Food Chemistry and Food Development Unit, Department of Life Technologies, University of Turku, 20014 Turku, Finland.
+ Hanhineva, Kati. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.
+ Paquot, Nicolas. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+ Cnop, Miriam. ULB Center for Diabetes Research, Medical Faculty, Universite Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
+ Cnop, Miriam. Division of Endocrinology, Erasmus Hospital, Universite Libre de Bruxelles, 1070 Brussels, Belgium.
+ Cani, Patrice D. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium.
+ Cani, Patrice D. WELBIO-Walloon Excellence in Life Sciences and BIOtechnology, UCLouvain, 1200 Brussels, Belgium.
+ Thissen, Jean-Paul. Pole of Endocrinology, Diabetes and Nutrition, Institut de Recherche Experimentale et Clinique IREC, UCLouvain, 1200 Brussels, Belgium.
+ Bindels, Laure B. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium.
+ Klein, Olivier. Center for Social and Cultural Psychology, Universite Libre de Bruxelles, 1000 Brussels, Belgium.
+ Luminet, Olivier. Research Institute for Psychological Sciences, UCLouvain, 1348 Louvain-la-Neuve, Belgium.
+ Delzenne, Nathalie M. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium.
+MeSH Subject Headings
+ Amino Acids/me [Metabolism]
+ *Biomarkers
+ Cross-Sectional Studies
+ Female
+ Gastrointestinal Microbiome/ph [Physiology]
+ *Gastrointestinal Microbiome
+ *Glutamine/aa [Analogs & Derivatives]
+ Glutamine/ec [Economics]
+ Glutamine/me [Metabolism]
+ Histidine/me [Metabolism]
+ Humans
+ Male
+ *Mood Disorders/di [Diagnosis]
+ Mood Disorders/et [Etiology]
+ Mood Disorders/me [Metabolism]
+ *Mood Disorders/mi [Microbiology]
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Obesity/mi [Microbiology]
+Keyword Heading
+ behaviour
+ metabolomics
+ microbiota
+ mood disorders
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with an increased risk of several neurological and psychiatric diseases, but few studies report the contribution of biological features in the occurrence of mood disorders in obese patients. The aim of the study is to evaluate the potential links between serum metabolomics and gut microbiome, and mood disturbances in a cohort of obese patients. Psychological, biological characteristics and nutritional habits were evaluated in 94 obese subjects from the Food4Gut study stratified according to their mood score assessed by the Positive and Negative Affect Schedule (PANAS). The fecal gut microbiota and plasma non-targeted metabolomics were analysed. Obese subjects with increased negative mood display elevated levels of Coprococcus as well as decreased levels of Sutterella and Lactobacillus. Serum metabolite profile analysis reveals in these subjects altered levels of several amino acid-derived metabolites, such as an increased level of L-histidine and a decreased in phenylacetylglutamine, linked to altered gut microbiota composition and function rather than to differences in dietary amino acid intake. Regarding clinical profile, we did not observe any differences between both groups. Our results reveal new microbiota-derived metabolites that characterize the alterations of mood in obese subjects, thereby allowing to propose new targets to tackle mood disturbances in this context. Food4gut, clinicaltrial.gov: NCT03852069.
+Registry Number/Name of Substance
+ 0 (Amino Acids). 0 (Biomarkers). 0RH81L854J (Glutamine). 4QD397987E (Histidine). 92358I79RG (phenylacetylglutamine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu14010147
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leyrolle&issn=2072-6643&title=Nutrients&atitle=Microbiota+and+Metabolite+Profiling+as+Markers+of+Mood+Disorders%3A+A+Cross-Sectional+Study+in+Obese+Patients.&volume=14&issue=1&spage=&epage=&date=2021&doi=10.3390%2Fnu14010147&pmid=35011021&sid=OVID:medline
+
+<685>
+Unique Identifier
+ 35010908
+Title
+ Randomized Clinical Trial to Evaluate the Morphological Changes in the Adventitial Vasa Vasorum Density and Biological Markers of Endothelial Dysfunction in Subjects with Moderate Obesity Undergoing a Very Low-Calorie Ketogenic Diet.
+Source
+ Nutrients. 14(1), 2021 Dec 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sanchez E; Santos MD; Nunez-Garcia M; Bueno M; Sajoux I; Yeramian A; Lecube A
+Author NameID
+ Sanchez, Enric; ORCID: https://orcid.org/0000-0001-7345-1601
+ Bueno, Marta; ORCID: https://orcid.org/0000-0001-9488-4553
+ Sajoux, Ignacio; ORCID: https://orcid.org/0000-0002-9405-9809
+ Yeramian, Andree; ORCID: https://orcid.org/0000-0002-9569-6316
+ Lecube, Albert; ORCID: https://orcid.org/0000-0001-9684-0183
+Authors Full Name
+ Sanchez, Enric; Santos, Maria-Dolores; Nunez-Garcia, Maitane; Bueno, Marta; Sajoux, Ignacio; Yeramian, Andree; Lecube, Albert.
+Institution
+ Sanchez, Enric. Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, 25198 Lleida, Spain.
+ Santos, Maria-Dolores. Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, 25198 Lleida, Spain.
+ Santos, Maria-Dolores. Endocrinology and Nutrition Department, Arnau de Vilanova University Hospital, 25198 Lleida, Spain.
+ Nunez-Garcia, Maitane. Pronokal Group, 08009 Barcelona, Spain.
+ Bueno, Marta. Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, 25198 Lleida, Spain.
+ Bueno, Marta. Endocrinology and Nutrition Department, Arnau de Vilanova University Hospital, 25198 Lleida, Spain.
+ Sajoux, Ignacio. Pronokal Group, 08009 Barcelona, Spain.
+ Yeramian, Andree. Endocrinology and Nutrition Department, Arnau de Vilanova University Hospital, 25198 Lleida, Spain.
+ Lecube, Albert. Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, 25198 Lleida, Spain.
+ Lecube, Albert. Endocrinology and Nutrition Department, Arnau de Vilanova University Hospital, 25198 Lleida, Spain.
+ Lecube, Albert. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+MeSH Subject Headings
+ Adult
+ Adventitia/pa [Pathology]
+ Biomarkers/bl [Blood]
+ Carotid Arteries/dg [Diagnostic Imaging]
+ Carotid Arteries/pa [Pathology]
+ Cholesterol, HDL/bl [Blood]
+ *Diet, Ketogenic/mt [Methods]
+ *Diet, Reducing/mt [Methods]
+ Endothelial Cells/pa [Pathology]
+ Female
+ Humans
+ Intercellular Adhesion Molecule-1/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pa [Pathology]
+ Plaque, Atherosclerotic/bl [Blood]
+ Quality of Life
+ Surveys and Questionnaires
+ Ultrasonography/mt [Methods]
+ Vasa Vasorum/dg [Diagnostic Imaging]
+ *Vasa Vasorum/pa [Pathology]
+ Vascular Cell Adhesion Molecule-1/bl [Blood]
+Keyword Heading
+ multidisciplinary approach
+ obesity
+ pronokal method
+ vasa vasorum
+ very low calorie ketogenic diet
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Weight loss after bariatric surgery decreases the earlier expansion of the adventitial vasa vasorum (VV), a biomarker of early atheromatous disease. However, no data are available regarding weight loss achieved by very low calorie ketogenic diets (VLCKD) on VV and lipid-based atherogenic indices. A randomized clinical trial was performed to examine changes in adventitial VV density in 20 patients with moderate obesity who underwent a 6-month very low calorie ketogenic diet (VLCKD, 600-800 kcal/day), and 10 participants with hypocaloric diet based on the Mediterranean Diet (MedDiet, estimated reduction of 500 kcal on the usual intake). Contrast-enhanced carotid ultrasound was used to assess the VV. Body composition analysis was also used. The atherogenic index of plasma (log (triglycerides to high-density lipoprotein cholesterol ratio)) and the triglyceride-glucose index were calculated. Serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured. The impact of weight on quality of life-lite (IWQOL-Lite) questionnaire was administered. Participants of intervention groups displayed a similar VV values. Significant improvements of BMI (-5.3 [-6.9 to -3.6] kg/m2, p < 0.001), total body fat (-7.0 [-10.7 to -3.3] %, p = 0.003), and IWQOL-Lite score (-41.4 [-75.2 to -7.6], p = 0.027) were observed in VLCKD group in comparison with MedDiet group. Although after a 6-months follow-up period VV density (mean, right and left sides) did not change significantly in any group, participants in the VLCKD exhibited a significantly decrease both in their atherogenic index of plasma and serum concentration of sICAM-1. A 6-month intervention with VLCKD do not impact in the density of the adventitial VV in subjects with moderate obesity, but induces significant changes in markers of endothelial dysfunction and CV risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Vascular Cell Adhesion Molecule-1). 126547-89-5 (Intercellular Adhesion Molecule-1).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu14010033
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sanchez&issn=2072-6643&title=Nutrients&atitle=Randomized+Clinical+Trial+to+Evaluate+the+Morphological+Changes+in+the+Adventitial+Vasa+Vasorum+Density+and+Biological+Markers+of+Endothelial+Dysfunction+in+Subjects+with+Moderate+Obesity+Undergoing+a+Very+Low-Calorie+Ketogenic+Diet.&volume=14&issue=1&spage=&epage=&date=2021&doi=10.3390%2Fnu14010033&pmid=35010908&sid=OVID:medline
+
+<686>
+Unique Identifier
+ 35010428
+Title
+ Effects of 40% of Maximum Oxygen Uptake Intensity Cycling Combined with Blood Flow Restriction Training on Body Composition and Serum Biomarkers of Chinese College Students with Obesity.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 19(1), 2021 12 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen Y; Ma C; Wang J; Gu Y; Gao Y
+Author NameID
+ Chen, Yong; ORCID: https://orcid.org/0000-0001-9867-0288
+Authors Full Name
+ Chen, Yong; Ma, Chunlin; Wang, Junmin; Gu, Ying; Gao, Yan.
+Institution
+ Chen, Yong. Department of Physical Education, Huaiyin Normal University, Huaian 223300, China.
+ Ma, Chunlin. Department of Physical Education, Huaiyin Normal University, Huaian 223300, China.
+ Wang, Junmin. Department of Physical Education, Huaiyin Normal University, Huaian 223300, China.
+ Gu, Ying. College of Sports Science, Shenyang Normal University, Shenyang 110034, China.
+ Gao, Yan. School of Foreign Languages, Shenyang Normal University, Shenyang 110034, China.
+MeSH Subject Headings
+ Biomarkers
+ *Blood Flow Restriction Therapy
+ Body Composition
+ China
+ Humans
+ Male
+ Obesity
+ Oxygen
+ *Oxygen Consumption
+ Pilot Projects
+ Students
+Keyword Heading
+ 40% of maximum oxygen uptake
+ blood flow restriction training
+ body composition
+ cycling
+ male college students
+ obesity
+ serum biomarkers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Blood flow restriction training (BFRT) is a new method for promoting muscle growth and improving muscle function, even with relatively low-intensity exercise. BFRT on patients with obesity has not been extensively studied. This study aimed to analyze the effects of cycling at 40% of maximum oxygen uptake (VO2max) combined with BFRT on body composition and serum biomarkers among college students with obesity. This pilot study included thirty-seven male college students with obesity aged 18-22 years (experimental group (EG): n = 18; control group (CG): n = 19). The EG conducted 40% VO2max cycling combined with BFRT activities and the CG conducted 40% VO2max cycling without BFRT two times per week for 12 weeks. Our results showed that in EG, there were significant differences in weight, thigh skinfold thickness (TS), waist circumference, abdominal skinfold thickness, fat mass, body fat percentage, body mass index and glucose (GLU), total cholesterol (TC), triglyceride, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels before and after the experiment (p < 0.05, p < 0.01, and p < 0.001). After the experiment, TS, GLU, TC, HDL-C, and LDL-C in EG were significantly different than those of the CG (p < 0.05, p < 0.01, and p < 0.001). Together, our results demonstrate that cycling at 40% VO2max combined with BFRT may improve body composition and blood lipid profile of male college students with obesity. Our findings have important implications for those who cannot perform moderate- and high-intensity exercises.
+Registry Number/Name of Substance
+ 0 (Biomarkers). S88TT14065 (Oxygen).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijerph19010168
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Effects+of+40%25+of+Maximum+Oxygen+Uptake+Intensity+Cycling+Combined+with+Blood+Flow+Restriction+Training+on+Body+Composition+and+Serum+Biomarkers+of+Chinese+College+Students+with+Obesity.&volume=19&issue=1&spage=&epage=&date=2021&doi=10.3390%2Fijerph19010168&pmid=35010428&sid=OVID:medline
+
+<687>
+Unique Identifier
+ 34993251
+Title
+ Evaluation of the Association between Obesity Markers and Type 2 Diabetes: A Cohort Study Based on a Physical Examination Population.
+Source
+ Journal of Diabetes Research. 2021:6503339, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang T; Zhao B; Pei D
+Author NameID
+ Yang, Tengfei; ORCID: https://orcid.org/0000-0002-6083-6139
+ Zhao, Bo; ORCID: https://orcid.org/0000-0001-8680-5288
+ Pei, Dongmei; ORCID: https://orcid.org/0000-0002-1947-4447
+Authors Full Name
+ Yang, Tengfei; Zhao, Bo; Pei, Dongmei.
+Institution
+ Yang, Tengfei. Department of Health Management, Shengjing Hospital of China Medical University, Shenyang, China.
+ Zhao, Bo. Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
+ Pei, Dongmei. Department of Health Management, Shengjing Hospital of China Medical University, Shenyang, China.
+MeSH Subject Headings
+ Adult
+ Area Under Curve
+ *Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Cohort Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Physical Examination
+ Proportional Hazards Models
+ ROC Curve
+ Retrospective Studies
+ Risk Factors
+ Waist Circumference
+Abstract
+ PURPOSE: To evaluate the predictive effect of different obesity markers on the risk of developing type 2 diabetes in a population of healthy individuals who underwent physical examination and to provide a reference for the early detection of individuals at risk of diabetes.
+
+ METHODS: This retrospective cohort study included 15206 healthy subjects who underwent a physical examination (8307 men and 6899 women). Information on the study population was obtained from the Dryad Digital Repository. Cox proportional risk models were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) of different obesity markers, including the lipid accumulation index (LAP), body mass index (BMI), waist-to-height ratio (WHtR), visceral adiposity index (VAI), and body roundness index (BRI) on the development of type 2 diabetes. The effectiveness of each obesity marker in predicting the risk of developing type 2 diabetes was analyzed using the receiver operating characteristic curve (ROC curve) and the area under the curve (AUC).
+
+ RESULTS: After a mean follow-up of 5.4 years, there were 372 new cases of type 2 diabetes. After correcting for confounding factors such as age, sex, smoking, alcohol consumption, exercise, and blood pressure, Cox proportional risk model analysis showed that elevations in BMI, LAP, WHtR, VAI, and BRI increased the risk of developing type 2 diabetes. The ROC curve results showed that LAP was the best predictor of the risk of developing diabetes, with an AUC (95% CI) of 0.759 (0.752-0.766), an optimal cutoff value of 16.04, a sensitivity of 0.72, and a specificity of 0.69.
+
+ CONCLUSION: An increase in the BMI, LAP, WHtR, VAI, and BRI can increase the risk of developing type 2 diabetes, with LAP being the best predictor of this risk. Copyright © 2021 Tengfei Yang et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f6503339
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=Evaluation+of+the+Association+between+Obesity+Markers+and+Type+2+Diabetes%3A+A+Cohort+Study+Based+on+a+Physical+Examination+Population.&volume=2021&issue=&spage=6503339&epage=&date=2021&doi=10.1155%2F2021%2F6503339&pmid=34993251&sid=OVID:medline
+
+<688>
+Unique Identifier
+ 34966822
+Title
+ Waist Circumference Is More Closely Associated with Hypogonadism than Is Hyperglycemia, Independent of BMI in Middle-Aged Men.
+Source
+ Journal of Diabetes Research. 2021:1347588, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hsu PS; Hung CL; Tu SK; Chen HH; Yang DH; Liao CC
+Author NameID
+ Hsu, Po-Sheng; ORCID: https://orcid.org/0000-0003-1149-650X
+ Liao, Chun-Cheng; ORCID: https://orcid.org/0000-0002-7508-6297
+Authors Full Name
+ Hsu, Po-Sheng; Hung, Chia-Lien; Tu, Shih-Kai; Chen, Hsin-Hung; Yang, Deng-Ho; Liao, Chun-Cheng.
+Institution
+ Hsu, Po-Sheng. Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan.
+ Hung, Chia-Lien. Department of Medical Education and Research, Taichung Armed Forces General Hospital, Taichung, Taiwan.
+ Tu, Shih-Kai. Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan.
+ Tu, Shih-Kai. School of Medicine, National Defense Medical Center, Taipei, Taiwan.
+ Chen, Hsin-Hung. Division of Endocrinology and Metabolism, Department of Internal Medicine, Asia University Hospital, Taichung, Taiwan.
+ Chen, Hsin-Hung. School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
+ Chen, Hsin-Hung. Chung Sheng Clinic, Nantou, Taiwan.
+ Yang, Deng-Ho. Department of Medical Education and Research, Taichung Armed Forces General Hospital, Taichung, Taiwan.
+ Yang, Deng-Ho. School of Medicine, National Defense Medical Center, Taipei, Taiwan.
+ Yang, Deng-Ho. Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan.
+ Liao, Chun-Cheng. Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan.
+ Liao, Chun-Cheng. Department of Medical Education and Research, Taichung Armed Forces General Hospital, Taichung, Taiwan.
+ Liao, Chun-Cheng. School of Medicine, National Defense Medical Center, Taipei, Taiwan.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Biomarkers/bl [Blood]
+ *Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ *Glycated Hemoglobin/an [Analysis]
+ Humans
+ Hyperglycemia/bl [Blood]
+ *Hyperglycemia/di [Diagnosis]
+ Hyperglycemia/ep [Epidemiology]
+ Hypogonadism/bl [Blood]
+ *Hypogonadism/di [Diagnosis]
+ Hypogonadism/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ Taiwan/ep [Epidemiology]
+ *Testosterone/bl [Blood]
+ *Waist Circumference
+Abstract
+ INTRODUCTION: To evaluate whether waist circumference (WC) or hyperglycemia is more closely associated with hypogonadism in middle-aged men. Research Design and Methods. This cross-sectional study analyzed male participants under 65 years old from the MJ Health Screening Center in Taiwan from 2007 to 2016. Basic patient characteristics with relevant parameters were obtained. We used the chi-square test to perform a correlation analysis for HbA1c and WC between participants with and without hypogonadism. A one-way ANOVA with post hoc Scheffe's method was applied to compare the mean testosterone (T) among the HbAlc and WC groups (normal blood sugar with normal WC (NBSNW), abnormal blood sugar with normal WC (ABSNW), normal blood sugar with abnormal WC (NBSAW), and abnormal blood sugar with abnormal waist circumference (ABSAW)).
+
+ RESULTS: The 5,680 participants were divided into two groups based on the presence (n = 599) or absence of hypogonadism (n = 5,081), which was defined as total testosterone (TT) < 300 ng/dL. The mean TT of group NBSAW (443.71 +/- 220.59 ng/dl) was significantly lower than that of group ABSNW (506.64 +/- 191.08 ng/dl, p < 0.001). Moreover, the mean TT of group ABSAW (398.89 +/- 146.24 ng/dl) was significantly lower than that of group ABSNW (506.64 +/- 191.08 ng/dl, p < 0.001). The ORs after adjusting for BMI, TG, HDL, SBP, and DBP were statistically significant when comparing NBSAW vs. NBSNW (OR = 2.846; 95%CI = 2.266-3.575; p < 0.001), ABSNW vs. NDNW (OR = 1.693; 95%CI = 1.309-2.189; p < 0.001), and ABSAW vs. NBSNW (OR = 4.613; 95%CI = 3.634-5.856; p < 0.001).
+
+ CONCLUSION: The current study showed that WC should be the risk factor that is more closely associated with hypogonadism than hyperglycemia in middle-aged men. Copyright © 2021 Po-Sheng Hsu et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human). 3XMK78S47O (Testosterone).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f1347588
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hsu&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=Waist+Circumference+Is+More+Closely+Associated+with+Hypogonadism+than+Is+Hyperglycemia%2C+Independent+of+BMI+in+Middle-Aged+Men.&volume=2021&issue=&spage=1347588&epage=&date=2021&doi=10.1155%2F2021%2F1347588&pmid=34966822&sid=OVID:medline
+
+<689>
+Unique Identifier
+ 34963447
+Title
+ Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity.
+Source
+ BMC Cardiovascular Disorders. 21(1):620, 2021 12 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang J; Liu M; Su E; Yu P; Jiang H; Zhao J; Ge J
+Authors Full Name
+ Huang, Jiaojiao; Liu, Ming; Su, Enyong; Yu, Peng; Jiang, Hong; Zhao, Ji; Ge, Junbo.
+Institution
+ Huang, Jiaojiao. Department of General Practice, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
+ Liu, Ming. Department of Health Management Center, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
+ Su, Enyong. Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Clinical Bioinformatics, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
+ Yu, Peng. Department of Endocrinology and Metabolism, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China. 15111210028@fudan.edu.cn.
+ Jiang, Hong. Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Clinical Bioinformatics, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China. jianghong_@fudan.edu.cn.
+ Zhao, Ji. Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Clinical Bioinformatics, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
+ Ge, Junbo. Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Clinical Bioinformatics, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Heart Disease Risk Factors
+ Heart Diseases/bl [Blood]
+ Heart Diseases/di [Diagnosis]
+ *Heart Diseases/et [Etiology]
+ Heart Diseases/pp [Physiopathology]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Predictive Value of Tests
+ Retrospective Studies
+ Risk Assessment
+ *Troponin T/bl [Blood]
+ Up-Regulation
+ *Ventricular Function, Left
+ *Ventricular Remodeling
+Keyword Heading
+ Coronary heart disease
+ High-sensitivity cardiac troponin T
+ Myocardial injury
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: It is well established that body mass index (BMI) and troponins are independently associated. However, whether the obesity could cause myocardial injury independent of coronary heart disease (CHD) remains unclear. This study focuses on the relationship between BMI and troponins, and whether this relationship is being attenuated when CHD is accounted for.
+
+ METHODS: In populations without acute ischemic events, 383 patients with coronary artery stenosis less than 75% were included, that is, people who have not yet reached the indications for coronary intervention, and of them 70 patients being obese according to BMI >= 28 kg/m2. Continuous variables were represented as mean +/- SD or median(inter quartile range[IQR]). Chi-square test was adopted for categorical data. Correlations between variables were evaluated by Spearman analysis, multiple regression or logistic regression.
+
+ RESULTS: The circulating hs-cTnT level was higher in the obese group [8(6,11) ng/L vs. 6(4,9) ng/L; p < 0.001). In subgroup analysis based on the presence or absence of coronary heart disease(CHD), the adjusted beta(95%CI) for circulating hs-cTnT exhibited a proportional relationship with BMI when the non-obesity were defined as the reference[beta; 2.22(95%CI, 0.73 to 3.71) in non-CHD, 5.58(95%CI, 0.70 to 10.46) in CHD, p < 0.05]. Additionally, the degree of coronary stenosis has shown a positive correlation with circulating hs-cTnT (rho = 0.1162; p < 0.05).
+
+ CONCLUSION: When CHD is taken into account, obesity is independently associated to the elevation of circulating hs-cTnT, a biomarker of myocardial injury, potentially indicating the impact of obesity on non-ischemic subclinical myocardial injury. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Troponin T).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12872-021-02445-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Elevated+circulating+high-sensitivity+cardiac+troponin+t+and+cardiac+remodeling+in+obesity.&volume=21&issue=1&spage=620&epage=&date=2021&doi=10.1186%2Fs12872-021-02445-0&pmid=34963447&sid=OVID:medline
+
+<690>
+Unique Identifier
+ 34960058
+Title
+ A Low-Glucose Eating Pattern Improves Biomarkers of Postmenopausal Breast Cancer Risk: An Exploratory Secondary Analysis of a Randomized Feasibility Trial.
+Source
+ Nutrients. 13(12), 2021 Dec 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schembre SM; Jospe MR; Giles ED; Sears DD; Liao Y; Basen-Engquist KM; Thomson CA
+Author NameID
+ Giles, Erin D; ORCID: https://orcid.org/0000-0002-8677-2831
+ Sears, Dorothy D; ORCID: https://orcid.org/0000-0002-9260-3540
+ Liao, Yue; ORCID: https://orcid.org/0000-0002-9384-336X
+Authors Full Name
+ Schembre, Susan M; Jospe, Michelle R; Giles, Erin D; Sears, Dorothy D; Liao, Yue; Basen-Engquist, Karen M; Thomson, Cynthia A.
+Institution
+ Schembre, Susan M. Department of Family and Community Medicine, College of Medicine-Tucson, University of Arizona, Tucson, AZ 85721, USA.
+ Jospe, Michelle R. Department of Family and Community Medicine, College of Medicine-Tucson, University of Arizona, Tucson, AZ 85721, USA.
+ Giles, Erin D. Department of Nutrition, Texas A & M University, College Station, TX 77843, USA.
+ Sears, Dorothy D. College of Health Solutions, Arizona State University, Tempe, AZ 85287, USA.
+ Liao, Yue. Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, USA.
+ Basen-Engquist, Karen M. Department of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
+ Thomson, Cynthia A. Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85721, USA.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Breast/me [Metabolism]
+ Breast Neoplasms/et [Etiology]
+ *Breast Neoplasms/pc [Prevention & Control]
+ *Diet/mt [Methods]
+ *Fasting/bl [Blood]
+ Feasibility Studies
+ Feeding Behavior/ph [Physiology]
+ Female
+ Humans
+ Insulin Resistance
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/dh [Diet Therapy]
+ *Postmenopause/bl [Blood]
+Keyword Heading
+ adherence
+ blood glucose
+ eating physiology
+ food intake regulation
+ metabolism
+ obesity
+ weight management
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Postmenopausal breast cancer is the most common obesity-related cancer death among women in the U.S. Insulin resistance, which worsens in the setting of obesity, is associated with higher breast cancer incidence and mortality. Maladaptive eating patterns driving insulin resistance represent a key modifiable risk factor for breast cancer. Emerging evidence suggests that time-restricted feeding paradigms (TRF) improve cancer-related metabolic risk factors; however, more flexible approaches could be more feasible and effective. In this exploratory, secondary analysis, we identified participants following a low-glucose eating pattern (LGEP), defined as consuming energy when glucose levels are at or below average fasting levels, as an alternative to TRF. Results show that following an LGEP regimen for at least 40% of reported eating events improves insulin resistance (HOMA-IR) and other cancer-related serum biomarkers. The magnitude of serum biomarkers changes observed here has previously been shown to favorably modulate benign breast tissue in women with overweight and obesity who are at risk for postmenopausal breast cancer. By comparison, the observed effects of LGEP were similar to results from previously published TRF studies in similar populations. These preliminary findings support further testing of LGEP as an alternative to TRF and a postmenopausal breast cancer prevention strategy. However, results should be interpreted with caution, given the exploratory nature of analyses.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13124508
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schembre&issn=2072-6643&title=Nutrients&atitle=A+Low-Glucose+Eating+Pattern+Improves+Biomarkers+of+Postmenopausal+Breast+Cancer+Risk%3A+An+Exploratory+Secondary+Analysis+of+a+Randomized+Feasibility+Trial.&volume=13&issue=12&spage=&epage=&date=2021&doi=10.3390%2Fnu13124508&pmid=34960058&sid=OVID:medline
+
+<691>
+Unique Identifier
+ 34959891
+Title
+ Relationship between Serum Angiopoietin-like Proteins 3 and 8 and Atherogenic Lipid Biomarkers in Non-Diabetic Adults Depends on Gender and Obesity.
+Source
+ Nutrients. 13(12), 2021 Nov 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Murawska K; Krintus M; Kuligowska-Prusinska M; Szternel L; Stefanska A; Sypniewska G
+Author NameID
+ Krintus, Magdalena; ORCID: https://orcid.org/0000-0003-2627-7473
+ Stefanska, Anna; ORCID: https://orcid.org/0000-0002-5295-2236
+ Sypniewska, Grazyna; ORCID: https://orcid.org/0000-0003-1350-7073
+Authors Full Name
+ Murawska, Karolina; Krintus, Magdalena; Kuligowska-Prusinska, Magdalena; Szternel, Lukasz; Stefanska, Anna; Sypniewska, Grazyna.
+Institution
+ Murawska, Karolina. Department of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87-110 Torun, Poland.
+ Krintus, Magdalena. Department of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87-110 Torun, Poland.
+ Kuligowska-Prusinska, Magdalena. Department of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87-110 Torun, Poland.
+ Szternel, Lukasz. Department of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87-110 Torun, Poland.
+ Stefanska, Anna. Department of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87-110 Torun, Poland.
+ Sypniewska, Grazyna. Department of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87-110 Torun, Poland.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Angiopoietin-Like Protein 3/bl [Blood]
+ *Angiopoietin-Like Protein 8/bl [Blood]
+ Atherosclerosis
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Hypertriglyceridemia/bl [Blood]
+ Hypertriglyceridemia/co [Complications]
+ Lipoproteins/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Peptide Hormones/bl [Blood]
+ *Sex Factors
+ Triglycerides/bl [Blood]
+Keyword Heading
+ angiopoietin-like proteins
+ cardiovascular risk
+ hypertriglyceridemia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Hypertriglyceridemia is an independent risk factor for coronary artery disease. Lipoprotein lipase (LPL) plays an essential role in the metabolism of triglyceride-rich lipoproteins (TRLs). Angiopoietin-like proteins ANGPTL3 and ANGPTL8 are shown to be important regulators of LPL activity. Increased concentrations of these proteins may reflect cardiovascular risk, and the treatment of patients with dyslipidemia with ANGPTLs inhibitors may decrease this risk. We assessed the gender-specific relationships of serum ANGPTL3 and ANGPTL8 with atherogenic lipid biomarkers and obesity in non-diabetic adults. The study comprised 238 participants aged 25-74 [122 with triglycerides (TG) <150 mg/dL (<1.7 mmol/L) and 116 with hypertriglyceridemia]. Total cholesterol, HDL-cholesterol, LDL-cholesterol, TG, C-reactive protein (CRP), glycated hemoglobin, apolipoprotein B, small dense LDL-C (sd-LDL-C), ANGPTL3, and ANGPTL8 were measured. Non-HDL-cholesterol, remnant cholesterol (remnant-C) concentrations, and body mass index (BMI) were calculated. Results: Women and men did not differ in terms of age, CRP levels, the percentage of obese subjects, and concentrations of atherogenic lipid biomarkers, except higher TG in males and higher ANGPTL3 concentrations in females. Positive correlations of both ANGPTLs with TG, remnant-C, and sdLDL-C levels were found in females. In males, only ANGPTL3 correlated positively with atherogenic biomarkers, but there were no correlations with ANGPTL8. Concentrations of ANGPTL3 were higher in obese men, whereas ANGPTL8 levels were higher in obese women. In women alone, ANGPTL8 showed very good discrimination power to identify subjects with hypertriglyceridemia (AUC = 0.83). Contrary to this, ANGPTL3 was a better discriminator of hypertriglyceridemia (AUC = 0.78) in male subjects. Regression models, adjusted for age, sex, and BMI showed a weak but significant effect of ANGPTL8 to increase the risk of hypertriglyceridemia. Conclusions : In females, ANGPTL8 is more strongly associated with TRLs metabolism, whereas in males, ANGPTL3 plays a more important role. We suggest sex differences be taken into consideration when applying new therapies with angiopoietin-like proteins inhibitors in the treatment of dyslipidemia.
+Registry Number/Name of Substance
+ 0 (ANGPTL3 protein, human). 0 (ANGPTL8 protein, human). 0 (Angiopoietin-Like Protein 3). 0 (Angiopoietin-Like Protein 8). 0 (Biomarkers). 0 (Lipoproteins). 0 (Peptide Hormones). 0 (Triglycerides). 0 (lipoprotein triglyceride). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13124339
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Murawska&issn=2072-6643&title=Nutrients&atitle=Relationship+between+Serum+Angiopoietin-like+Proteins+3+and+8+and+Atherogenic+Lipid+Biomarkers+in+Non-Diabetic+Adults+Depends+on+Gender+and+Obesity.&volume=13&issue=12&spage=&epage=&date=2021&doi=10.3390%2Fnu13124339&pmid=34959891&sid=OVID:medline
+
+<692>
+Unique Identifier
+ 34944069
+Title
+ Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A1 Receptor Ligands.
+Source
+ Cells. 10(12), 2021 12 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zuccarini M; Lambertucci C; Carluccio M; Giuliani P; Ronci M; Spinaci A; Volpini R; Ciccarelli R; Di Iorio P
+Author NameID
+ Lambertucci, Catia; ORCID: https://orcid.org/0000-0003-2004-1531
+ Ronci, Maurizio; ORCID: https://orcid.org/0000-0002-0797-6087
+ Volpini, Rosaria; ORCID: https://orcid.org/0000-0002-5304-5232
+ Ciccarelli, Renata; ORCID: https://orcid.org/0000-0003-1412-738X
+Authors Full Name
+ Zuccarini, Mariachiara; Lambertucci, Catia; Carluccio, Marzia; Giuliani, Patricia; Ronci, Maurizio; Spinaci, Andrea; Volpini, Rosaria; Ciccarelli, Renata; Di Iorio, Patrizia.
+Institution
+ Zuccarini, Mariachiara. Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
+ Zuccarini, Mariachiara. Center for Advanced Study and Technologies (CAST), University of Chieti-Pescara, Via L. Polacchi 11, 66100 Chieti, Italy.
+ Lambertucci, Catia. Unit of Medicinal Chemistry, School of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
+ Carluccio, Marzia. Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
+ Carluccio, Marzia. Center for Advanced Study and Technologies (CAST), University of Chieti-Pescara, Via L. Polacchi 11, 66100 Chieti, Italy.
+ Carluccio, Marzia. Stem TeCh Group, Via L. Polacchi 11, 66100 Chieti, Italy.
+ Giuliani, Patricia. Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
+ Giuliani, Patricia. Center for Advanced Study and Technologies (CAST), University of Chieti-Pescara, Via L. Polacchi 11, 66100 Chieti, Italy.
+ Ronci, Maurizio. Department of Pharmacy, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
+ Spinaci, Andrea. Unit of Medicinal Chemistry, School of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
+ Volpini, Rosaria. Unit of Medicinal Chemistry, School of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
+ Ciccarelli, Renata. Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
+ Ciccarelli, Renata. Center for Advanced Study and Technologies (CAST), University of Chieti-Pescara, Via L. Polacchi 11, 66100 Chieti, Italy.
+ Ciccarelli, Renata. Unit of Medicinal Chemistry, School of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
+ Di Iorio, Patrizia. Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
+ Di Iorio, Patrizia. Center for Advanced Study and Technologies (CAST), University of Chieti-Pescara, Via L. Polacchi 11, 66100 Chieti, Italy.
+MeSH Subject Headings
+ Adenosine A1 Receptor Agonists/pd [Pharmacology]
+ Adipogenesis/de [Drug Effects]
+ *Adipogenesis
+ Adult
+ Apoptosis/de [Drug Effects]
+ Biomarkers/me [Metabolism]
+ *Body Weight
+ Cell Proliferation/de [Drug Effects]
+ Female
+ Humans
+ Ligands
+ Mesenchymal Stem Cells/cy [Cytology]
+ *Mesenchymal Stem Cells/pa [Pathology]
+ Necrosis
+ *Obesity/pa [Pathology]
+ Phosphatidylinositol 3-Kinase/me [Metabolism]
+ Phosphorylation/de [Drug Effects]
+ Proto-Oncogene Proteins c-akt/me [Metabolism]
+ *Receptor, Adenosine A1/me [Metabolism]
+ Signal Transduction/de [Drug Effects]
+ *Subcutaneous Fat/pa [Pathology]
+Keyword Heading
+ adenosine A1 receptors
+ adipogenic differentiation
+ adipogenic markers
+ adipose stromal cells (ASCs)
+ subcutaneous adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adenosine A1 receptor (A1R) activation, stimulating lipogenesis and decreasing insulin resistance, could be useful for metabolic syndrome management in obese subjects. Since full A1R agonists induce harmful side-effects, while partial agonists show a better pharmacological profile, we investigated the influence of two derivatives of the full A1R agonist 2-chloro-N6-cyclopentyladenosine (CCPA), C1 and C2 behaving as A1R partial agonists in animal models, on the adipogenic differentiation of stromal/stem cells (ASCs) from human subcutaneous adipose tissue, which mainly contribute to increase fat mass in obesity. The ASCs from normal-weight subjects showed increased proliferation and A1R expression but reduced adipogenic differentiation compared to obese individual-derived ASCs. Cell exposure to CCPA, C1, C2 or DPCPX, an A1R antagonist, did not affect ASC proliferation, while mainly C2 and DPCPX significantly decreased adipogenic differentiation of both ASC types, reducing the activity of glycerol-3-phosphate dehydrogenase and the expression of PPARgamma and FABP-4, all adipogenic markers, and phosphorylation of Akt in the phosphatidylinositol-3-kinase pathway, which plays a key-role in adipogenesis. While requiring confirmation in in vivo models, our results suggest that A1R partial agonists or antagonists, by limiting ASC differentiation into adipocytes and, thereby, fat mass expansion, could favor development/worsening of metabolic syndrome in obese subjects without a dietary control.
+Registry Number/Name of Substance
+ 0 (Adenosine A1 Receptor Agonists). 0 (Biomarkers). 0 (Ligands). 0 (Receptor, Adenosine A1). EC 2-7-1-137 (Phosphatidylinositol 3-Kinase). EC 2-7-11-1 (Proto-Oncogene Proteins c-akt).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fcells10123560
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zuccarini&issn=2073-4409&title=Cells&atitle=Multipotent+Stromal+Cells+from+Subcutaneous+Adipose+Tissue+of+Normal+Weight+and+Obese+Subjects%3A+Modulation+of+Their+Adipogenic+Differentiation+by+Adenosine+A1+Receptor+Ligands.&volume=10&issue=12&spage=&epage=&date=2021&doi=10.3390%2Fcells10123560&pmid=34944069&sid=OVID:medline
+
+<693>
+Unique Identifier
+ 34868459
+Title
+ Gender-Specific Behaviour in Obesity Stages I-II: Imbalance of Aminothiol Status and Adipomyokine Profile in Subjects with Different Insulin Resistance Severity.
+Source
+ Oxidative medicine & cellular longevity. 2021:9713582, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Campolo J; Corradi E; Parolini M; Di Guglielmo ML; Rizzardi A; Dellanoce C; Tarlarini P; Cattaneo M; Scioscioli E; Trivella MG; De Maria R
+Author NameID
+ Campolo, Jonica; ORCID: https://orcid.org/0000-0002-1711-6216
+ Parolini, Marina; ORCID: https://orcid.org/0000-0003-2670-8536
+ Dellanoce, Cinzia; ORCID: https://orcid.org/0000-0002-0750-6261
+ Trivella, Maria Giovanna; ORCID: https://orcid.org/0000-0001-8702-2859
+ De Maria, Renata; ORCID: https://orcid.org/0000-0002-8474-7923
+Authors Full Name
+ Campolo, Jonica; Corradi, Ettore; Parolini, Marina; Di Guglielmo, Maria Luisa; Rizzardi, Alice; Dellanoce, Cinzia; Tarlarini, Patrizia; Cattaneo, Marina; Scioscioli, Elena; Trivella, Maria Giovanna; De Maria, Renata.
+Institution
+ Campolo, Jonica. CNR Institute of Clinical Physiology, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Corradi, Ettore. Clinical Nutritional Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Parolini, Marina. CNR Institute of Clinical Physiology, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Di Guglielmo, Maria Luisa. CNR Institute of Clinical Physiology, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Rizzardi, Alice. CNR Institute of Clinical Physiology, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Dellanoce, Cinzia. CNR Institute of Clinical Physiology, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Tarlarini, Patrizia. Clinical Nutritional Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Cattaneo, Marina. Clinical Nutritional Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Scioscioli, Elena. Clinical Nutritional Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ Trivella, Maria Giovanna. CNR Institute of Clinical Physiology, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+ De Maria, Renata. CNR Institute of Clinical Physiology, ASST Grande Ospedale Metropolitano Niguarda, Milan 20162, Italy.
+MeSH Subject Headings
+ Aged
+ *Biomarkers/bl [Blood]
+ Female
+ Humans
+ *Insulin Resistance/ge [Genetics]
+ Male
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ Sex Characteristics
+Abstract
+ The hyperproduction of oxidative stress and inflammatory biomarkers, which is paralleled by decreased levels of antioxidant and anti-inflammatory mediators, is part of cellular mechanisms that contribute to the disruption of metabolic homeostasis in obesity. Whether gender-specific alterations and gender-restricted associations in these biomarkers underlie the increased cardiometabolic risk in men compared to women is unclear. We enrolled 31 women and 29 men, aged >=50 and <=70 years and with body mass index >= 30 and <40 kg/m2. We assessed the concentrations of aminothiols (cysteine, homocysteine, and glutathione), expression of oxidant/antioxidant balance, adipomyokines (leptin, adiponectin, myostatin, and interleukin-6), markers of chronic inflammation, and vitamin D, an index of nutritional state, in plasma and serum samples by using HPLC, ELISA, and chemiluminescent immunoassay methods. We measured insulin resistance (IR) by the homeostasis model assessment (HOMA) index. Despite comparable levels of visceral adiposity, IR, and a similar dietary regimen, men showed, with respect to women, higher oxidant concentrations and lower antioxidant levels, which paralleled IR severity. Myostatin levels correlated with prooxidant aminothiols among men only. Gender-specific alterations in aminothiol status and adipomyokine profile and the gender-restricted association between these biomarkers and metabolic derangement are consistent with an increased cardiometabolic risk in men compared to age-matched women with stage I-II obesity. Strict control of redox and inflammatory status, even addressing gender-specific nutritional targets, may be useful to prevent obesity-related metabolic alterations and comorbidities. Copyright © 2021 Jonica Campolo et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f9713582
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Campolo&issn=1942-0994&title=Oxidative+medicine+%26+cellular+longevity&atitle=Gender-Specific+Behaviour+in+Obesity+Stages+I-II%3A+Imbalance+of+Aminothiol+Status+and+Adipomyokine+Profile+in+Subjects+with+Different+Insulin+Resistance+Severity.&volume=2021&issue=&spage=9713582&epage=&date=2021&doi=10.1155%2F2021%2F9713582&pmid=34868459&sid=OVID:medline
+
+<694>
+Unique Identifier
+ 34865797
+Title
+ Production and characterization of nanoemulsion with low-calorie structured lipids and its potential to modulate biomarkers associated with obesity and comorbidities.
+Source
+ Food Research International. 150(Pt A):110782, 2021 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gandra RLP; Zuin JC; Moreira DKT; Fernandes ACF; Gambero A; Ribeiro APB; Macedo GA; Macedo JA
+Authors Full Name
+ Gandra, Renata Luana de Padua; Zuin, Julia Cristina; Moreira, Debora Kono Taketa; Fernandes, Annayara Celestina Ferreira; Gambero, Alessandra; Ribeiro, Ana Paula Badan; Macedo, Gabriela Alves; Macedo, Juliana Alves.
+Institution
+ Gandra, Renata Luana de Padua. Department of Food and Nutrition, School of Food Engineering, State University of Campinas, Monteiro Lobato St. 80, zip code: 13083-862, Campinas, SP, Brazil. Electronic address: renatagandra@yahoo.com.br.
+ Zuin, Julia Cristina. Department of Food and Nutrition, School of Food Engineering, State University of Campinas, Monteiro Lobato St. 80, zip code: 13083-862, Campinas, SP, Brazil.
+ Moreira, Debora Kono Taketa. Department of Science and Technology, Federal Institute of Brasilia, Lote 01, DF 480, multiple activities sector, zipe code, 72429-005 Brasilia, DF, Brazil.
+ Fernandes, Annayara Celestina Ferreira. Department of Food and Nutrition, School of Food Engineering, State University of Campinas, Monteiro Lobato St. 80, zip code: 13083-862, Campinas, SP, Brazil.
+ Gambero, Alessandra. Life Science Center, Pontifical Catholic University of Campinas, John Boyd Dunlop, S/N, zip code: 13034-685, Campinas, SP, Brazil.
+ Ribeiro, Ana Paula Badan. Department of Food Technology, School of Food Engineering, State University of Campinas, Monteiro Lobato street, 80, zip code: 13083-862, Campinas, SP, Brazil.
+ Macedo, Gabriela Alves. Department of Food and Nutrition, School of Food Engineering, State University of Campinas, Monteiro Lobato St. 80, zip code: 13083-862, Campinas, SP, Brazil.
+ Macedo, Juliana Alves. Department of Food and Nutrition, School of Food Engineering, State University of Campinas, Monteiro Lobato St. 80, zip code: 13083-862, Campinas, SP, Brazil.
+MeSH Subject Headings
+ Biomarkers
+ Emulsions
+ *Energy Intake
+ Humans
+ Obesity
+ *Soybean Oil
+Keyword Heading
+ Behenic acid
+ In vitro digestion
+ Nanoemulsion
+ Obesity
+ Structured lipids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Structured lipids (SL) containing behenic acid have been produced in order to obtain low-calorie lipids for foods; however, the development of a high nutritional value and a stable nanoemulsion carrier system for these SL is an interesting breakthrough for this field of research, improving technologic and biological potential for food application. In this sense, the aim of this study was to evaluate the stability of a nanoemulsion containing SL NeSL (produced with olive oil, soybean oil and fully hydrogenated crambe oil), the behavior during in vitro digestion and the effects on biomarkers involved in the obesity in cell models. The samples showed good stability throughout storage (30 days) under refrigeration and room temperature and after the gastric digestion phase compared to the controls (nanoemulsion of olive and soybean oil). After the intestinal phase, there was an increase in oil droplet size and zeta potential, a characteristic of coalescence. In the lipid accumulation model in adipocytes, the highest concentration (50 microL/mL) of NeSL resulted in 42% less lipid accumulation, compared to the control. Furthermore, the sample was able to reduce inflammatory cytokines produced by macrophages provoked by LPS (lipopolysaccharide). The combination of the oils in NeSL resulted in a fatty acid profile with beneficial health properties, which may have contributed to less lipid accumulation and improved inflammatory parameters. This SL in the form of a nanoemulsion, may be used as a partial fat substitute in low-calorie food products. Copyright © 2021 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Emulsions). 8001-22-7 (Soybean Oil).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.foodres.2021.110782
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gandra&issn=0963-9969&title=Food+Research+International&atitle=Production+and+characterization+of+nanoemulsion+with+low-calorie+structured+lipids+and+its+potential+to+modulate+biomarkers+associated+with+obesity+and+comorbidities.&volume=150&issue=&spage=110782&epage=&date=2021&doi=10.1016%2Fj.foodres.2021.110782&pmid=34865797&sid=OVID:medline
+
+<695>
+Unique Identifier
+ 34859866
+Title
+ Cholesteryl ester transfer protein rs5833 genetic variant affect HDL-cholesterol levels and ratio total cholesterol/HDL-cholesterol in postmenopausal obese female patient.
+Source
+ European Review for Medical & Pharmacological Sciences. 25(22):7030-7036, 2021 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Luis DA; Izaola O; Primo D; Gomez E; Lopez J
+Authors Full Name
+ de Luis, D A; Izaola, O; Primo, D; Gomez, E; Lopez, J.
+Institution
+ de Luis, D A. Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es.
+MeSH Subject Headings
+ Adiposity
+ Aged
+ Biomarkers
+ Blood Pressure
+ *Cholesterol/bl [Blood]
+ *Cholesterol Ester Transfer Proteins/ge [Genetics]
+ Exercise
+ Female
+ Genotype
+ Humans
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/ge [Genetics]
+ Polymorphism, Single Nucleotide
+ *Postmenopause/bl [Blood]
+ *Postmenopause/ge [Genetics]
+Abstract
+ OBJECTIVE: One SNP in exon 9 (r5883) has been involved with high risk of cardiovascular disease in hypertensive subjects. The goal of the present study was to test the role of this genetic variant on lipid levels and Metabolic Syndrome (MS) in menopausal obese females.
+
+ PATIENTS AND METHODS: The study enrolled a sample of 112 menopausal obese females. Measurements of adiposity parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C reactive protein and prevalence of MS were recorded. Genotype of CETP gene polymorphism (rs5883) was studied.
+
+ RESULTS: The distribution of the rs5883 polymorphism in this menopausal obese population was 83.9% (n=94) (CC), 15.2% (n=17) (CT) and 0.9% (n=1) (TT). Adiposity parameters, blood pressure, fasting glucose levels, insulin levels, HOMA-IR, C reactive protein, total cholesterol, LDL-cholesterol and triglycerides were similar in both genotype groups (CC vs. CT+TT). Moreover, HDL cholesterol (8.5+1.2 mg/dl; p=0.01) and ratio total cholesterol/HDL-cholesterol (0.5+/-0.2; p=0.04) were higher in T allele carriers (dominant model). MS percentage was similar in both genotypes (37.6% vs. 27.2%; p=0.43). Logistic regression analysis showed a decreased risk of low-HDL cholesterol in T allele carriers (OR=0.18, 95% CI=0.02-0.77, p=0.03) after adjusting by dietary fatty acid intakes, body mass index and age.
+
+ CONCLUSIONS: The results reported here support that CETP variant rs5883 is related with HDL-cholesterol levels and ratio total cholesterol/HDL-cholesterol.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CETP protein, human). 0 (Cholesterol Ester Transfer Proteins). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.26355%2feurrev_202111_27253
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Luis&issn=1128-3602&title=European+Review+for+Medical+%26+Pharmacological+Sciences&atitle=Cholesteryl+ester+transfer+protein+rs5833+genetic+variant+affect+HDL-cholesterol+levels+and+ratio+total+cholesterol%2FHDL-cholesterol+in+postmenopausal+obese+female+patient.&volume=25&issue=22&spage=7030&epage=7036&date=2021&doi=10.26355%2Feurrev_202111_27253&pmid=34859866&sid=OVID:medline
+
+<696>
+Unique Identifier
+ 34847893
+Title
+ Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population.
+Source
+ BMC Cardiovascular Disorders. 21(1):570, 2021 11 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu R; Zhang Q; Peng N; Xu S; Zhang M; Hu Y; Chen Z; Tang K; He X; Li Y; Shi L
+Authors Full Name
+ Liu, Ruoyi; Zhang, Qiao; Peng, Nianchun; Xu, Shujing; Zhang, Miao; Hu, Ying; Chen, Zhengyi; Tang, Kun; He, Xi; Li, Yi; Shi, Lixin.
+Institution
+ Liu, Ruoyi. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ Zhang, Qiao. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ Peng, Nianchun. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ Xu, Shujing. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ Zhang, Miao. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ Hu, Ying. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ Chen, Zhengyi. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ Tang, Kun. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ He, Xi. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ He, Xi. Department of Endocrinology and Metabolism, Guizhou Provincial People's Hospital, Guiyang, 550001, China.
+ Li, Yi. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China.
+ Shi, Lixin. Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, 550001, China. liuruoyi731@126.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/ep [Epidemiology]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/ep [Epidemiology]
+ Female
+ *Fibronectins/bl [Blood]
+ Heart Disease Risk Factors
+ Humans
+ Hypertension/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Risk Assessment
+ Smoking/ae [Adverse Effects]
+ Smoking/ep [Epidemiology]
+Keyword Heading
+ Cardiovascular disease
+ Diabetes mellitus
+ Dyslipidemia
+ Hypertension
+ Irisin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among Chinese overweight/obese population.
+
+ METHODS: A total of 98 overweight and 93 obese subjects without clinical treatments were enrolled in this study. Subjects were then divided into two groups, based on the serum irisin level: a low irisin group (1.10-13.44 ng/ml) and a high irisin group (13.49-29.9 ng/ml). The clustering of CVRFs, smoking, diabetes mellitus, dyslipidemia and hypertension, was classified as 0, 1, 2 and >= 3 CVRFs. The demographic and baseline clinical characteristics of all participants were collected and serum irisin was measured.
+
+ RESULTS: The high serum irisin group had significantly higher high-density lipoprotein cholesterol but lower fasting plasma glucose than the low serum irisin group. Additionally, the high serum irisin group had a significantly lower prevalence of smoking, diabetes mellitus and dyslipidemia than the low serum irisin group. Increased serum irisin was significantly associated with a reduced risk of smoking and dyslipidemia in both the unadjusted and adjusted models. Furthermore, high serum irisin significantly reduced the risk of the prevalence of 1, 2 and >= 3 CVRFs.
+
+ CONCLUSIONS: among the Chinese overweight/obese populations, high serum irisin is negatively associated with smoking, dyslipidemia and the clustering of CVRFs. Thus, high serum irisin is potentially associated with a low risk of cardiovascular diseases in the Chinese overweight/obese population. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FNDC5 protein, human). 0 (Fibronectins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12872-021-02380-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Inverse+correlation+between+serum+irisin+and+cardiovascular+risk+factors+among+Chinese+overweight%2Fobese+population.&volume=21&issue=1&spage=570&epage=&date=2021&doi=10.1186%2Fs12872-021-02380-0&pmid=34847893&sid=OVID:medline
+
+<697>
+Unique Identifier
+ 34847213
+Title
+ Curcumin supplementation improves biomarkers of oxidative stress and inflammation in conditions of obesity, type 2 diabetes and NAFLD: updating the status of clinical evidence.
+Source
+ Food & Function. 12(24):12235-12249, 2021 Dec 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mokgalaboni K; Ntamo Y; Ziqubu K; Nyambuya TM; Nkambule BB; Mazibuko-Mbeje SE; Gabuza KB; Chellan N; Tiano L; Dludla PV
+Author NameID
+ Mokgalaboni, Kabelo; ORCID: http://orcid.org/0000-0002-3224-7433
+ Ntamo, Yonela; ORCID: http://orcid.org/0000-0002-7724-9547
+ Dludla, Phiwayinkosi V; ORCID: http://orcid.org/0000-0001-5965-3610
+Authors Full Name
+ Mokgalaboni, Kabelo; Ntamo, Yonela; Ziqubu, Khanyisani; Nyambuya, Tawanda M; Nkambule, Bongani B; Mazibuko-Mbeje, Sithandiwe E; Gabuza, Kwazikwakhe B; Chellan, Nireshni; Tiano, Luca; Dludla, Phiwayinkosi V.
+Institution
+ Mokgalaboni, Kabelo. School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
+ Ntamo, Yonela. Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa. pdludla@mrc.ac.za.
+ Ziqubu, Khanyisani. Department of Biochemistry, North-West University, Mmabatho 2745, South Africa.
+ Nyambuya, Tawanda M. Department of Health Sciences, Namibia University of Science and Technology, Windhoek 9000, Namibia.
+ Nkambule, Bongani B. School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
+ Mazibuko-Mbeje, Sithandiwe E. Department of Biochemistry, North-West University, Mmabatho 2745, South Africa.
+ Gabuza, Kwazikwakhe B. School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
+ Chellan, Nireshni. Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa. pdludla@mrc.ac.za.
+ Chellan, Nireshni. Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa.
+ Tiano, Luca. Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona 60131, Italy.
+ Dludla, Phiwayinkosi V. Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa. pdludla@mrc.ac.za.
+MeSH Subject Headings
+ *Antioxidants/ad [Administration & Dosage]
+ Biomarkers/bl [Blood]
+ *Curcumin/ad [Administration & Dosage]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/dh [Diet Therapy]
+ *Dietary Supplements
+ Functional Food
+ Humans
+ Inflammation
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/dh [Diet Therapy]
+ Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Oxidative Stress/de [Drug Effects]
+Abstract
+ Oxidative stress and inflammation remain the major complications implicated in the development and progression of metabolic complications, including obesity, type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). In fact, due to their abundant antioxidant and anti-inflammatory properties, there is a general interest in understanding the therapeutic effects of some major food-derived bioactive compounds like curcumin against diverse metabolic diseases. Hence, a systematic search, through prominent online databases such as MEDLINE, Scopus, and Google Scholar was done focusing on randomized controlled trials (RCTs) reporting on the impact of curcumin supplementation in individuals with diverse metabolic complications, including obesity, T2D and NAFLD. Summarized findings suggest that curcumin supplementation can significantly reduce blood glucose and triglycerides levels, including markers of liver function like alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in patients with T2D and NAFLD. Importantly, this effect was consistent with the reduction of predominant markers of oxidative stress and inflammation, such as the levels of malonaldehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), high sensitivity C-reactive protein (hs-CRP) and monocyte chemoattractant protein-1 (MCP-1) in these patients. Although RCTs suggest that curcumin is beneficial in ameliorating some metabolic complications, future research is still necessary to enhance its absorption and bioavailability profile, while also optimizing the most effective therapeutic doses.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). IT942ZTH98 (Curcumin).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1039%2fd1fo02696h
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mokgalaboni&issn=2042-6496&title=Food+%26+Function&atitle=Curcumin+supplementation+improves+biomarkers+of+oxidative+stress+and+inflammation+in+conditions+of+obesity%2C+type+2+diabetes+and+NAFLD%3A+updating+the+status+of+clinical+evidence.&volume=12&issue=24&spage=12235&epage=12249&date=2021&doi=10.1039%2Fd1fo02696h&pmid=34847213&sid=OVID:medline
+
+<698>
+Unique Identifier
+ 34845204
+Title
+ High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control.
+Source
+ Nature communications . 12(1):6951, 2021 11 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dreyfuss JM; Yuchi Y; Dong X; Efthymiou V; Pan H; Simonson DC; Vernon A; Halperin F; Aryal P; Konkar A; Sebastian Y; Higgs BW; Grimsby J; Rondinone CM; Kasif S; Kahn BB; Foster K; Seeley R; Goldfine A; Djordjilovic V; Patti ME
+Author NameID
+ Dreyfuss, Jonathan M; ORCID: http://orcid.org/0000-0001-7242-3991
+ Yuchi, Yixing; ORCID: http://orcid.org/0000-0002-9439-0913
+ Efthymiou, Vissarion; ORCID: http://orcid.org/0000-0003-4327-7977
+ Pan, Hui; ORCID: http://orcid.org/0000-0001-5748-7217
+ Simonson, Donald C; ORCID: http://orcid.org/0000-0002-4670-6290
+ Aryal, Pratik; ORCID: http://orcid.org/0000-0001-6443-8974
+ Kasif, Simon; ORCID: http://orcid.org/0000-0003-3297-9914
+ Kahn, Barbara B; ORCID: http://orcid.org/0000-0002-4027-0000
+ Seeley, Randy; ORCID: http://orcid.org/0000-0002-3721-5625
+ Goldfine, Allison; ORCID: http://orcid.org/0000-0002-0345-1048
+ Djordjilovic, Vera; ORCID: http://orcid.org/0000-0002-7670-3111
+ Patti, Mary Elizabeth; ORCID: http://orcid.org/0000-0002-8163-3429
+Authors Full Name
+ Dreyfuss, Jonathan M; Yuchi, Yixing; Dong, Xuehong; Efthymiou, Vissarion; Pan, Hui; Simonson, Donald C; Vernon, Ashley; Halperin, Florencia; Aryal, Pratik; Konkar, Anish; Sebastian, Yinong; Higgs, Brandon W; Grimsby, Joseph; Rondinone, Cristina M; Kasif, Simon; Kahn, Barbara B; Foster, Kathleen; Seeley, Randy; Goldfine, Allison; Djordjilovic, Vera; Patti, Mary Elizabeth.
+Institution
+ Dreyfuss, Jonathan M. Bioinformatics and Biostatistics Core, Research Division, Joslin Diabetes Center, Boston, MA, USA.
+ Dreyfuss, Jonathan M. Biomedical Engineering, Boston University, Boston, MA, USA.
+ Dreyfuss, Jonathan M. Harvard Medical School, Boston, MA, USA.
+ Yuchi, Yixing. Harvard Medical School, Boston, MA, USA.
+ Yuchi, Yixing. Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Boston, MA, USA.
+ Yuchi, Yixing. Vertex Pharmaceuticals, Boston, MA, USA.
+ Dong, Xuehong. Harvard Medical School, Boston, MA, USA.
+ Dong, Xuehong. Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Boston, MA, USA.
+ Dong, Xuehong. Department of Endocrinology, Diabetes & Metabolism, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
+ Efthymiou, Vissarion. Harvard Medical School, Boston, MA, USA.
+ Efthymiou, Vissarion. Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Boston, MA, USA.
+ Pan, Hui. Bioinformatics and Biostatistics Core, Research Division, Joslin Diabetes Center, Boston, MA, USA.
+ Pan, Hui. Biomedical Engineering, Boston University, Boston, MA, USA.
+ Simonson, Donald C. Harvard Medical School, Boston, MA, USA.
+ Simonson, Donald C. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
+ Vernon, Ashley. Harvard Medical School, Boston, MA, USA.
+ Vernon, Ashley. Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
+ Halperin, Florencia. Harvard Medical School, Boston, MA, USA.
+ Halperin, Florencia. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
+ Halperin, Florencia. Form Health, Boston, MA, USA.
+ Aryal, Pratik. Harvard Medical School, Boston, MA, USA.
+ Aryal, Pratik. Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
+ Konkar, Anish. MedImmune, Gaithersburg, MD, USA.
+ Konkar, Anish. Eli Lilly and Company, Indianapolis, IN, USA.
+ Sebastian, Yinong. MedImmune, Gaithersburg, MD, USA.
+ Higgs, Brandon W. MedImmune, Gaithersburg, MD, USA.
+ Higgs, Brandon W. Genmab, Plainsboro, NJ, USA.
+ Grimsby, Joseph. MedImmune, Gaithersburg, MD, USA.
+ Grimsby, Joseph. AstraZeneca, Gaithersburg, MD, USA.
+ Rondinone, Cristina M. MedImmune, Gaithersburg, MD, USA.
+ Kasif, Simon. Biomedical Engineering, Boston University, Boston, MA, USA.
+ Kahn, Barbara B. Harvard Medical School, Boston, MA, USA.
+ Kahn, Barbara B. Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
+ Foster, Kathleen. Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Boston, MA, USA.
+ Seeley, Randy. Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
+ Goldfine, Allison. Harvard Medical School, Boston, MA, USA.
+ Goldfine, Allison. Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Boston, MA, USA.
+ Goldfine, Allison. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
+ Goldfine, Allison. Novartis Institute for Biomedical Research, Cambridge, MA, USA.
+ Djordjilovic, Vera. Department of Economics, Ca' Foscari University of Venice, Venice, Italy.
+ Patti, Mary Elizabeth. Harvard Medical School, Boston, MA, USA. MaryElizabeth.Patti@joslin.harvard.edu.
+ Patti, Mary Elizabeth. Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Boston, MA, USA. MaryElizabeth.Patti@joslin.harvard.edu.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Carrier Proteins/bl [Blood]
+ Carrier Proteins/ge [Genetics]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Diabetes Mellitus, Type 2/su [Surgery]
+ Dipeptidases/bl [Blood]
+ Dipeptidases/ge [Genetics]
+ Fasting/ph [Physiology]
+ *Gastric Bypass
+ Gene Expression Regulation
+ Glycated Hemoglobin/ge [Genetics]
+ Glycated Hemoglobin/me [Metabolism]
+ Hepatocytes/me [Metabolism]
+ Hepatocytes/pa [Pathology]
+ Human Growth Hormone/bl [Blood]
+ Human Growth Hormone/ge [Genetics]
+ Humans
+ Insulin-Like Growth Factor Binding Protein 1/bl [Blood]
+ Insulin-Like Growth Factor Binding Protein 1/ge [Genetics]
+ Insulin-Like Growth Factor Binding Protein 2/bl [Blood]
+ Insulin-Like Growth Factor Binding Protein 2/ge [Genetics]
+ *Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ *Metabolome
+ *Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ Obesity/su [Surgery]
+ Primary Cell Culture
+ *Proteome
+ Rats
+ Retrospective Studies
+Abstract
+ To improve the power of mediation in high-throughput studies, here we introduce High-throughput mediation analysis (Hitman), which accounts for direction of mediation and applies empirical Bayesian linear modeling. We apply Hitman in a retrospective, exploratory analysis of the SLIMM-T2D clinical trial in which participants with type 2 diabetes were randomized to Roux-en-Y gastric bypass (RYGB) or nonsurgical diabetes/weight management, and fasting plasma proteome and metabolome were assayed up to 3 years. RYGB caused greater improvement in HbA1c, which was mediated by growth hormone receptor (GHR). GHR's mediation is more significant than clinical mediators, including BMI. GHR decreases at 3 months postoperatively alongside increased insulin-like growth factor binding proteins IGFBP1/BP2; plasma GH increased at 1 year. Experimental validation indicates (1) hepatic GHR expression decreases in post-bariatric rats; (2) GHR knockdown in primary hepatocytes decreases gluconeogenic gene expression and glucose production. Thus, RYGB may induce resistance to diabetogenic effects of GH signaling.Trial Registration: Clinicaltrials.gov NCT01073020. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Carrier Proteins). 0 (Glycated Hemoglobin A). 0 (IGFBP1 protein, human). 0 (IGFBP2 protein, human). 0 (Insulin-Like Growth Factor Binding Protein 1). 0 (Insulin-Like Growth Factor Binding Protein 2). 0 (Proteome). 0 (hemoglobin A1c protein, human). 12629-01-5 (Human Growth Hormone). EC 3-4-13 (CNDP1 protein, human). EC 3-4-13 (Dipeptidases). W06KFL3RDT (somatotropin-binding protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41467-021-27289-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dreyfuss&issn=2041-1723&title=Nature+communications+&atitle=High-throughput+mediation+analysis+of+human+proteome+and+metabolome+identifies+mediators+of+post-bariatric+surgical+diabetes+control.&volume=12&issue=1&spage=6951&epage=&date=2021&doi=10.1038%2Fs41467-021-27289-2&pmid=34845204&sid=OVID:medline
+
+<699>
+Unique Identifier
+ 34836283
+Title
+ Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes.
+Source
+ Nutrients. 13(11), 2021 Nov 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aittola K; Karhunen L; Mannikko R; Jarvela-Reijonen E; Mikkonen S; Absetz P; Kolehmainen M; Schwab U; Harjumaa M; Lindstrom J; Lakka T; Tilles-Tirkkonen T; Pihlajamaki J
+Author NameID
+ Aittola, Kirsikka; ORCID: https://orcid.org/0000-0002-6283-7805
+ Karhunen, Leila; ORCID: https://orcid.org/0000-0001-5801-8041
+ Mikkonen, Santtu; ORCID: https://orcid.org/0000-0003-0595-0657
+ Kolehmainen, Marjukka; ORCID: https://orcid.org/0000-0002-3770-2538
+ Schwab, Ursula; ORCID: https://orcid.org/0000-0003-1838-7525
+ Lindstrom, Jaana; ORCID: https://orcid.org/0000-0001-9255-020X
+ Tilles-Tirkkonen, Tanja; ORCID: https://orcid.org/0000-0002-8268-3401
+Authors Full Name
+ Aittola, Kirsikka; Karhunen, Leila; Mannikko, Reija; Jarvela-Reijonen, Elina; Mikkonen, Santtu; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Harjumaa, Marja; Lindstrom, Jaana; Lakka, Timo; Tilles-Tirkkonen, Tanja; Pihlajamaki, Jussi.
+Institution
+ Aittola, Kirsikka. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Karhunen, Leila. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Mannikko, Reija. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Mannikko, Reija. Endocrinology and Clinical Nutrition, Department of Medicine, Kuopio University Hospital, 70029 Kuopio, Finland.
+ Jarvela-Reijonen, Elina. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Mikkonen, Santtu. Department of Applied Physics, University of Eastern Finland, 70211 Kuopio, Finland.
+ Absetz, Pilvikki. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Absetz, Pilvikki. Collaborative Care Systems Finland, 00270 Helsinki, Finland.
+ Kolehmainen, Marjukka. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Schwab, Ursula. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Schwab, Ursula. Endocrinology and Clinical Nutrition, Department of Medicine, Kuopio University Hospital, 70029 Kuopio, Finland.
+ Harjumaa, Marja. VTT Technical Research Centre of Finland Ltd., 02044 Espoo, Finland.
+ Lindstrom, Jaana. Department of Public Health and Welfare, National Institute for Health and Welfare, 00271 Helsinki, Finland.
+ Lakka, Timo. Institute of Biomedicine, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Lakka, Timo. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, 70029 Kuopio, Finland.
+ Lakka, Timo. Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
+ Tilles-Tirkkonen, Tanja. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Pihlajamaki, Jussi. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
+ Pihlajamaki, Jussi. Endocrinology and Clinical Nutrition, Department of Medicine, Kuopio University Hospital, 70029 Kuopio, Finland.
+MeSH Subject Headings
+ Adiposity
+ Biomarkers
+ Body Mass Index
+ *Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Delivery of Health Care
+ *Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ *Diet
+ *Eating
+ Exercise
+ *Feeding Behavior
+ Finland
+ Glucose
+ Humans
+ Life Style
+ Lipid Metabolism
+ Meals
+ Obesity/pc [Prevention & Control]
+ Overweight
+ Risk Assessment
+ Risk Factors
+ Surveys and Questionnaires
+Keyword Heading
+ adiposity
+ diet
+ diet quality
+ eating behavior
+ glucose metabolism
+ health care
+ lifestyle
+ lipid metabolism
+ obesity
+ overweight
+ prevention
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Eating competence (EC) is characterized by positive attitudes towards food and eating, having regular meals, eating a variety of foods, and internally regulated eating. We investigated the associations of changes in EC with changes in lifestyle, anthropometrics and biomarkers of glucose and lipid metabolism in 2291 adults at increased risk of type 2 diabetes as part of the StopDia study conducted in primary healthcare. EC and diet quality were assessed with validated digital questionnaires. During the intervention, the participants received either (1) the digital lifestyle intervention, (2) the combined digital and face-to-face group-based lifestyle intervention, or (3) standard care. EC increased among the participants independent of the intervention type. Increase in EC was associated with an increase in diet quality, high-density lipoprotein (HDL) cholesterol, and with a decrease in body mass index and waist circumference, regardless of baseline EC. Of the subdomains of EC, the contextual skills, food acceptance and eating attitudes were associated with various of these changes. Our results thus suggest that EC could be a potential target in lifestyle interventions aiming to improve the cardiometabolic health of people at type 2 diabetes risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13114030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aittola&issn=2072-6643&title=Nutrients&atitle=Enhanced+Eating+Competence+Is+Associated+with+Improved+Diet+Quality+and+Cardiometabolic+Profile+in+Finnish+Adults+with+Increased+Risk+of+Type+2+Diabetes.&volume=13&issue=11&spage=&epage=&date=2021&doi=10.3390%2Fnu13114030&pmid=34836283&sid=OVID:medline
+
+<700>
+Unique Identifier
+ 34836213
+Title
+ Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999-2006.
+Source
+ Nutrients. 13(11), 2021 Nov 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karanth SD; Washington C; Cheng TD; Zhou D; Leeuwenburgh C; Braithwaite D; Zhang D
+Author NameID
+ Karanth, Shama D; ORCID: https://orcid.org/0000-0001-5371-6908
+ Washington, Caretia; ORCID: https://orcid.org/0000-0002-1205-5848
+ Cheng, Ting-Yuan D; ORCID: https://orcid.org/0000-0002-4105-828X
+Authors Full Name
+ Karanth, Shama D; Washington, Caretia; Cheng, Ting-Yuan D; Zhou, Daohong; Leeuwenburgh, Christiaan; Braithwaite, Dejana; Zhang, Dongyu.
+Institution
+ Karanth, Shama D. Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32610, USA.
+ Karanth, Shama D. University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.
+ Washington, Caretia. College of Medicine, University of Florida, Gainesville, FL 32610, USA.
+ Cheng, Ting-Yuan D. University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.
+ Cheng, Ting-Yuan D. Department of Epidemiology, University of Florida, Gainesville, FL 32610, USA.
+ Zhou, Daohong. University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.
+ Zhou, Daohong. Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
+ Leeuwenburgh, Christiaan. Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32610, USA.
+ Braithwaite, Dejana. Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32610, USA.
+ Braithwaite, Dejana. University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.
+ Braithwaite, Dejana. Department of Epidemiology, University of Florida, Gainesville, FL 32610, USA.
+ Zhang, Dongyu. University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.
+ Zhang, Dongyu. Department of Epidemiology, University of Florida, Gainesville, FL 32610, USA.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Chronic Disease
+ *Comorbidity
+ Female
+ Humans
+ *Inflammation/co [Complications]
+ Logistic Models
+ Male
+ Middle Aged
+ Multivariate Analysis
+ Nutrition Surveys
+ *Obesity/co [Complications]
+ *Sarcopenia/co [Complications]
+Keyword Heading
+ epidemiology
+ inflammation
+ sarcopenia
+ sarcopenic obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Loss of muscle mass and waning in muscle strength are common in older adults, and inflammation may play a key role in pathogenesis. This study aimed to examine associations of C-reactive protein (CRP) and systemic immune-inflammation index (SII) with sarcopenia and sarcopenic obesity in older adults with chronic comorbidities. Cross-sectional data from the National Health and Nutrition Examination Survey (1999-2006) were obtained for participants aged >=60 years. Sarcopenia was defined by a lean mass and body height (males < 7.26 kg/m2, females < 5.45 kg/m2). Sarcopenic obesity was defined by the concurrent presence of sarcopenia and obesity (defined by relative fat mass). Logistic regression was used to assess the associations of CRP and SII with sarcopenia and sarcopenic obesity. The dose-response relationship was examined via restricted cubic splines. Of the participants (n = 2483), 23.1% (n = 574) and 7.7% (n = 190) had sarcopenia and sarcopenic obesity, respectively. The multivariable logistic regression models suggested a positive association of SII with sarcopenia and sarcopenic obesity, but a positive statistically significant association was not consistently observed for CRP. Dose-response curves suggested similar association patterns for these biomarkers. In clinical practice, measures to prevent sarcopenia and sarcopenic obesity are needed for older vulnerable people with high systemic inflammation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13113957
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karanth&issn=2072-6643&title=Nutrients&atitle=Inflammation+in+Relation+to+Sarcopenia+and+Sarcopenic+Obesity+among+Older+Adults+Living+with+Chronic+Comorbidities%3A+Results+from+the+National+Health+and+Nutrition+Examination+Survey+1999-2006.&volume=13&issue=11&spage=&epage=&date=2021&doi=10.3390%2Fnu13113957&pmid=34836213&sid=OVID:medline
+
+<701>
+Unique Identifier
+ 34819543
+Title
+ Responses of different functional tests in candidates for bariatric surgery and the association with body composition, metabolic and lipid profile.
+Source
+ Scientific Reports. 11(1):22840, 2021 11 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ricci PA; Andre LD; Jurgensen SP; de Oliveira CR; Ortega FP; Di Thommazo-Luporini L; Borghi-Silva A
+Authors Full Name
+ Ricci, Paula Angelica; Andre, Larissa Delgado; Jurgensen, Soraia Pilon; de Oliveira, Claudio Ricardo; Ortega, Fernando Pinheiro; Di Thommazo-Luporini, Luciana; Borghi-Silva, Audrey.
+Institution
+ Ricci, Paula Angelica. Cardiopulmonary Physiotherapy Laboratory, Federal University of Sao Carlos - UFSCar, Rod. Washington Luis, km 235, Sao Carlos, 13565-905, Brazil.
+ Andre, Larissa Delgado. Cardiopulmonary Physiotherapy Laboratory, Federal University of Sao Carlos - UFSCar, Rod. Washington Luis, km 235, Sao Carlos, 13565-905, Brazil.
+ Jurgensen, Soraia Pilon. Cardiopulmonary Physiotherapy Laboratory, Federal University of Sao Carlos - UFSCar, Rod. Washington Luis, km 235, Sao Carlos, 13565-905, Brazil.
+ de Oliveira, Claudio Ricardo. Department of Medicine, Federal University of Sao Carlos, Sao Carlos, SP, Brazil.
+ Ortega, Fernando Pinheiro. Ortega Clinic, Sao Carlos, SP, Brazil.
+ Di Thommazo-Luporini, Luciana. Cardiopulmonary Physiotherapy Laboratory, Federal University of Sao Carlos - UFSCar, Rod. Washington Luis, km 235, Sao Carlos, 13565-905, Brazil.
+ Borghi-Silva, Audrey. Cardiopulmonary Physiotherapy Laboratory, Federal University of Sao Carlos - UFSCar, Rod. Washington Luis, km 235, Sao Carlos, 13565-905, Brazil. audrey@ufscar.br.
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ Adult
+ Bariatric Surgery
+ Biomarkers/bl [Blood]
+ *Cardiorespiratory Fitness
+ Cross-Sectional Studies
+ *Energy Metabolism
+ *Exercise Test
+ *Exercise Tolerance
+ Female
+ Functional Status
+ Humans
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ Obesity/su [Surgery]
+ Predictive Value of Tests
+ Reproducibility of Results
+ Time Factors
+ Walk Test
+ Young Adult
+Abstract
+ Individuals with obesity can have metabolic disorders and may develop impairments that affect the ability to exercise. The maximal incremental cardiopulmonary exercise test is widely used to assess functional capacity. However, submaximal tests such as the two-minute step test (2MST) and the six-minute walk test (6MWT) also allow this assessment. We propose to analyze whether body composition, metabolic and lipid profile influence the maximal and submaximal performance, and investigate these variables in response to different functional tests. Forty-four individuals with obesity, aged 18-50 years, underwent analysis of body composition, metabolic and lipid profile, incremental treadmill test (ITMT), 6MWT, and 2MST. One-way ANOVA, Pearson or Spearman correlation, and Stepwise multiple linear regression analysis were performed. ITMT induced a greater metabolic, ventilatory, cardiovascular, and perceived exertion demand when compared to the 6MWT and 2MST (p < 0.05). In addition, 2MST elicited a higher chronotropic (HR) and metabolic (VO2) demand when compared to the 6MWT (p < 0.05). Significant correlations were found between tests and body composition, metabolic and lipid profile. Fat mass and low-density lipoprotein can explain 30% of the VO2 variance in the ITMT; and fat mass, glucose, and performance in the 2MST can explain 42% of the variance of the distance walked in the ITMT. Obesity and its metabolic impairments are capable of influencing responses to exercise. ITMT generated greater demand due to the high stress imposed, however, 2MST demanded greater metabolic and chronotropic demand when compared to the 6MWT. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Comparative Study. Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-02072-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ricci&issn=2045-2322&title=Scientific+Reports&atitle=Responses+of+different+functional+tests+in+candidates+for+bariatric+surgery+and+the+association+with+body+composition%2C+metabolic+and+lipid+profile.&volume=11&issue=1&spage=22840&epage=&date=2021&doi=10.1038%2Fs41598-021-02072-x&pmid=34819543&sid=OVID:medline
+
+<702>
+Unique Identifier
+ 34769133
+Title
+ Salivary Adipokine and Cytokine Levels as Potential Markers for the Development of Obesity and Metabolic Disorders. [Review]
+Source
+ International Journal of Molecular Sciences. 22(21), 2021 Oct 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zysk B; Ostrowska L; Smarkusz-Zarzecka J
+Author NameID
+ Zysk, Beata; ORCID: https://orcid.org/0000-0002-9821-9347
+ Ostrowska, Lucyna; ORCID: https://orcid.org/0000-0002-0543-1817
+ Smarkusz-Zarzecka, Joanna; ORCID: https://orcid.org/0000-0003-3504-951X
+Authors Full Name
+ Zysk, Beata; Ostrowska, Lucyna; Smarkusz-Zarzecka, Joanna.
+Institution
+ Zysk, Beata. Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Ul. Mieszka I 4B, 15-054 Bialystok, Poland.
+ Ostrowska, Lucyna. Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Ul. Mieszka I 4B, 15-054 Bialystok, Poland.
+ Smarkusz-Zarzecka, Joanna. Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Ul. Mieszka I 4B, 15-054 Bialystok, Poland.
+MeSH Subject Headings
+ *Adipokines/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ *Biomarkers/me [Metabolism]
+ *Cytokines/me [Metabolism]
+ Humans
+ Obesity/di [Diagnosis]
+ *Obesity/me [Metabolism]
+ *Saliva/me [Metabolism]
+Keyword Heading
+ adipokines
+ cytokines
+ obesity diagnostics
+ obesity markers
+ saliva
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Currently, the number of people suffering from obesity is increasing worldwide. In addition, the disease is affecting younger individuals. Therefore, it is essential to search for new diagnostic methods and markers for early assessment of the risk of obesity, metabolic disorders, and other comorbidities. The discovery of the secretory function of adipose tissue and coexistence of low-grade chronic inflammation with obesity set a new direction in this disease diagnosis using the assessment of the concentration of inflammatory markers secreted by adipose tissue. The aim of this review was to determine, based on previous findings, whether saliva can be useful in the diagnosis of obesity and its early metabolic complications and whether it can be an alternative diagnostic material to serum.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms222111703
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zysk&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Salivary+Adipokine+and+Cytokine+Levels+as+Potential+Markers+for+the+Development+of+Obesity+and+Metabolic+Disorders.&volume=22&issue=21&spage=11703&epage=&date=2021&doi=10.3390%2Fijms222111703&pmid=34769133&sid=OVID:medline
+
+<703>
+Unique Identifier
+ 34762789
+Title
+ Effects of an interdisciplinary weight loss program on fibroblast growth factor 21 and inflammatory biomarkers in women with overweight and obesity.
+Source
+ Archives of Endocrinology & Metabolism. 65(6):821-831, 2021 Nov 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Damaso AR; Machado PP; Rhein SO; Masquio DCL; Oyama LM; Boldarine VT; de Oliveira GI; Tock L; Thivel D; da Silveira Campos RM
+Authors Full Name
+ Damaso, Ana Raimunda; Machado, Paola Prospero; Rhein, Samantha Ottani; Masquio, Deborah Cristina Landi; Oyama, Lila Missae; Boldarine, Valter Tadeu; de Oliveira, Gabriela Iervolino; Tock, Lian; Thivel, David; da Silveira Campos, Raquel Munhoz.
+Institution
+ Damaso, Ana Raimunda. Programa de Pos-graduacao em Nutricao, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil, ana.damaso@unifesp.br.
+ Machado, Paola Prospero. Programa de Pos-graduacao em Nutricao, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
+ Rhein, Samantha Ottani. Programa de Pos-graduacao em Nutricao, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
+ Masquio, Deborah Cristina Landi. Centro Universitario Sao Camilo, Sao Paulo, SP, Brasil.
+ Oyama, Lila Missae. Programa de Pos-graduacao em Nutricao, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
+ Oyama, Lila Missae. Departamento de Fisiologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
+ Boldarine, Valter Tadeu. Programa de Pos-graduacao em Nutricao, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
+ Boldarine, Valter Tadeu. Departamento de Fisiologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
+ de Oliveira, Gabriela Iervolino. Grupo de Estudos da Obesidade (GEO/UNIFESP), Escola Paulista de Medicina, Sao Paulo, SP, Brasil.
+ Tock, Lian. Grupo de Estudos da Obesidade (GEO/UNIFESP), Escola Paulista de Medicina, Sao Paulo, SP, Brasil.
+ Thivel, David. Clermont Auvergne University, EA 3533, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, France; CRNH-Auvergne, Clermont-Ferrand, France.
+ da Silveira Campos, Raquel Munhoz. Departamento de Biociencias, Universidade Federal de Sao Paulo, Campus Baixada Santista, Santos, SP, Brasil, raquel.munhoz@unifesp.br.
+ da Silveira Campos, Raquel Munhoz. Programa de Pos-Graduacao Interdisciplinar em Ciencias da Saude, Universidade Federal de Sao Paulo, Campus Baixada Santista, Santos, SP, Brasil.
+MeSH Subject Headings
+ Adiponectin
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Female
+ *Fibroblast Growth Factors/bl [Blood]
+ Humans
+ Insulin Resistance
+ Leptin
+ Obesity/th [Therapy]
+ *Obesity
+ Overweight/th [Therapy]
+ *Overweight
+ *Weight Reduction Programs
+Keyword Heading
+ Adiposity
+ inflammation
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To investigate the effects of an interdisciplinary intervention on biomarkers of inflammation and their relationship with fibroblast growth factor 21 (FGF21) concentrations in women with overweight and obesity.
+
+ METHODS: Thirty-one women were enrolled in a 12-week interdisciplinary weight loss program delivered by a team comprising an endocrinologist, nutritionist and exercise physiologist. Body composition; anthropometric measures; metabolic and inflammatory markers including adiponectin, leptin, and atrial natriuretic peptide (ANP) were assessed at baseline and post-therapy. The homeostasis model assessment of insulin resistance (HOMA-IR) and the homeostasis model assessment of adiponectin (HOMA-AD) were calculated. The participants were divided into two groups: those with increased FGF21, and those with decreased FGF21.
+
+ RESULTS: The sample comprised women aged 32 +/- 5 years with a body mass index of 33.64 +/- 3.49 kg/m2. Body weight, waist circumference and leptin concentration were decreased in the whole sample after therapy. However, only the group with an increase in FGF21 concentration presented significant improvements in adiponectin concentration and adiponectin/leptin ratio. Moreover, although there was a reduction of leptin in both groups, it was greater in the increased FGF21 groups. There was a reduction in ANP in the decreased FGF21 group.
+
+ CONCLUSION: Changes in FGF21 concentrations were different among the women participating in the weight loss program, with some having increased levels and some reduced levels. Furthermore, improvements in adiponectin and the adiponectin/leptin ratio were found only in the group with increased FGF21 concentration.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.20945%2f2359-3997000000419
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Damaso&issn=2359-3997&title=Archives+of+Endocrinology+%26+Metabolism&atitle=Effects+of+an+interdisciplinary+weight+loss+program+on+fibroblast+growth+factor+21+and+inflammatory+biomarkers+in+women+with+overweight+and+obesity.&volume=65&issue=6&spage=821&epage=831&date=2021&doi=10.20945%2F2359-3997000000419&pmid=34762789&sid=OVID:medline
+
+<704>
+Unique Identifier
+ 34761580
+Title
+ Obesity is a predictive biomarker of poor benefit from single-agent bevacizumab therapy in recurrent ovarian cancer patients.
+Source
+ Journal of B.U.On.. 26(5):1762-1767, 2021 Sep-Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yoshida H; Shintani D; Fujiwara K
+Authors Full Name
+ Yoshida, Hiroyuki; Shintani, Daisuke; Fujiwara, Keiichi.
+Institution
+ Yoshida, Hiroyuki. Department of Gynecologic Oncology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.
+MeSH Subject Headings
+ *Antineoplastic Agents, Immunological/ae [Adverse Effects]
+ Antineoplastic Agents, Immunological/pd [Pharmacology]
+ *Bevacizumab/ae [Adverse Effects]
+ Bevacizumab/pd [Pharmacology]
+ *Biomarkers/me [Metabolism]
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ *Ovarian Neoplasms/dt [Drug Therapy]
+ Prognosis
+ Retrospective Studies
+Abstract
+ PURPOSE: Bevacizumab, an anti-angiogenic agent targeting vascular endothelial growth factor (VEGF), is widely used for the treatment of ovarian cancer. However, no predictive biomarkers of clinical outcome for bevacizumab therapy have been identified. Adipose tissue secretes various growth factors, including VEGF, which may neutralize bevacizumab and attenuate its effects. Therefore, we evaluated whether obesity is a predictive biomarker of clinical outcome in ovarian cancer patients treated with single-agent bevacizumab.
+
+ METHODS: Thirty patients with recurrent ovarian cancer treated with single-agent bevacizumab were studied. Body mass index (BMI) and visceral fat area (VFA) were measured to assess the presence of obesity. VFA was measured using computed tomography volume-analyzing software. The association of BMI and VFA with clinical outcomes were evaluated.
+
+ RESULTS: High BMI and high VFA were significantly correlated with progressive disease (p=0.0195 and p=0.0352, respectively). A significant correlation was identified between high BMI and progressive disease in multivariate analysis (p=0.0459). Furthermore, there was a trend toward shorter progression-free survival and a significant shortening of overall survival in high-BMI patients compared with low-BMI patients (p=0.101 and p=0.0417, respectively).
+
+ CONCLUSIONS: This study demonstrated that obesity is a predictive biomarker of poor benefit from single-agent bevacizumab therapy in recurrent ovarian cancer patients. Obesity may be a useful benchmark for the administration of bevacizumab in daily clinical practice.
+Registry Number/Name of Substance
+ 0 (Antineoplastic Agents, Immunological). 0 (Biomarkers). 2S9ZZM9Q9V (Bevacizumab).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&AN=34761580
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yoshida&issn=1107-0625&title=Journal+of+B.U.On.&atitle=Obesity+is+a+predictive+biomarker+of+poor+benefit+from+single-agent+bevacizumab+therapy+in+recurrent+ovarian+cancer+patients.&volume=26&issue=5&spage=1762&epage=1767&date=2021&doi=&pmid=34761580&sid=OVID:medline
+
+<705>
+Unique Identifier
+ 34757919
+Title
+ PM20D1 is a circulating biomarker closely associated with obesity, insulin resistance and metabolic syndrome.
+Source
+ European Journal of Endocrinology. 186(2):151-161, 2021 Dec 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang R; Hu Y; Lee CH; Liu Y; Diaz-Canestro C; Fong CHY; Lin H; Cheng KKY; Pravelil AP; Song E; Lam KSL; Xu A
+Authors Full Name
+ Yang, Ranyao; Hu, Yue; Lee, Chi Ho; Liu, Yan; Diaz-Canestro, Candela; Fong, Carol Ho Yi; Lin, Huige; Cheng, Kenneth K Y; Pravelil, Aparna Padmanabhan; Song, Erfei; Lam, Karen S L; Xu, Aimin.
+Institution
+ Yang, Ranyao. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.
+ Yang, Ranyao. Department of Medicine, The University of Hong Kong, Hong Kong, China.
+ Hu, Yue. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.
+ Hu, Yue. Department of Medicine, The University of Hong Kong, Hong Kong, China.
+ Lee, Chi Ho. Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
+ Liu, Yan. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.
+ Liu, Yan. Department of Medicine, The University of Hong Kong, Hong Kong, China.
+ Diaz-Canestro, Candela. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.
+ Diaz-Canestro, Candela. Department of Medicine, The University of Hong Kong, Hong Kong, China.
+ Fong, Carol Ho Yi. Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
+ Lin, Huige. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
+ Cheng, Kenneth K Y. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
+ Pravelil, Aparna Padmanabhan. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.
+ Pravelil, Aparna Padmanabhan. Department of Medicine, The University of Hong Kong, Hong Kong, China.
+ Song, Erfei. Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
+ Lam, Karen S L. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.
+ Lam, Karen S L. Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
+ Xu, Aimin. State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.
+ Xu, Aimin. Department of Medicine, The University of Hong Kong, Hong Kong, China.
+ Xu, Aimin. Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Amidohydrolases/bl [Blood]
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ HEK293 Cells
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+Abstract
+ OBJECTIVE: Peptidase M20 domain containing 1 (PM20D1), a secreted enzyme catalysing condensation of fatty acids and amino acids into the bioactive lipids N-acyl amino acids (NAAA), induces uncoupling protein 1 (UCP1)-independent adaptive thermogenesis in brown/beige adipocytes in mice. This study aimed to explore the associations of the circulating levels of PM20D1 and major NAAA with obesity-related metabolic complications in humans.
+
+ DESIGN AND METHODS: Serum concentrations of PM20D1 and NAAA (C18:1-Leu and C18:1-Phe) in 256 Chinese subjects, including 78 lean and 178 overweight/obese individuals with or without diabetes, were measured with immunoassays and liquid chromatography-mass spectrometry, respectively. The impact of sulfonylurea and rosiglitazone on their circulating levels was examined in 62 patients with type 2 diabetes.
+
+ RESULTS: Serum PM20D1 level was significantly elevated in overweight/obese individuals and was closely associated with circulating levels of C18:1-Leu and C18:1-Phe. Furthermore, serum PM20D1, C18:1-Leu and C18:1-Phe concentrations correlated positively with several parameters of adiposity as well as fasting and 2 h postprandial glucose, HbA1c, fasting insulin and HOMA-IR independent of BMI and age. Moreover, a significant elevation in PM20D1, C18:1-Leu and C18:1-Phe concentrations corresponding with increases in the number of components of the metabolic syndrome (MetS) was observed. Treatment with sulfonylurea significantly decreased circulating PM20D1, C18:1-Leu and C18:1-Phe in patients with type 2 diabetes.
+
+ CONCLUSIONS: Increased serum levels of PM20D1 and its catalytic products NAAA are closely associated with obesity-related glucose dysregulation, insulin resistance and MetS and can be potentially used as clinical biomarkers for diagnosing and monitoring these disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-5 (Amidohydrolases). EC 3-5 (PM20D1 protein, human).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1530%2fEJE-21-0847
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=0804-4643&title=European+Journal+of+Endocrinology&atitle=PM20D1+is+a+circulating+biomarker+closely+associated+with+obesity%2C+insulin+resistance+and+metabolic+syndrome.&volume=186&issue=2&spage=151&epage=161&date=2021&doi=10.1530%2FEJE-21-0847&pmid=34757919&sid=OVID:medline
+
+<706>
+Unique Identifier
+ 34750570
+Title
+ Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2.
+Source
+ Nature Metabolism. 3(11):1569-1584, 2021 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jiang Y; Peng J; Song J; He J; Jiang M; Wang J; Ma L; Wang Y; Lin M; Wu H; Zhang Z; Gao D; Zhao Y
+Author NameID
+ Jiang, Yiao; ORCID: http://orcid.org/0000-0001-8236-4868
+ Gao, Dong; ORCID: http://orcid.org/0000-0003-1821-2741
+ Zhao, Yun; ORCID: http://orcid.org/0000-0002-7807-6094
+Authors Full Name
+ Jiang, Yiao; Peng, Jiayin; Song, Jiawen; He, Juan; Jiang, Man; Wang, Jia; Ma, Liya; Wang, Yuang; Lin, Moubin; Wu, Hailong; Zhang, Zhao; Gao, Dong; Zhao, Yun.
+Institution
+ Jiang, Yiao. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Peng, Jiayin. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Song, Jiawen. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ He, Juan. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Jiang, Man. School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
+ Wang, Jia. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Ma, Liya. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Wang, Yuang. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Lin, Moubin. Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
+ Wu, Hailong. Shanghai Key Laboratory for Molecular Imaging, Collaborative Research Center, Shanghai University of Medicine and Health Science, Shanghai, P. R. China.
+ Zhang, Zhao. Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA.
+ Zhang, Zhao. Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
+ Gao, Dong. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
+ Gao, Dong. Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shangha, China.
+ Gao, Dong. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
+ Zhao, Yun. The State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. yunzhao@sibcb.ac.cn.
+ Zhao, Yun. School of Life Science and Technology, ShanghaiTech University, Shanghai, China. yunzhao@sibcb.ac.cn.
+ Zhao, Yun. School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China. yunzhao@sibcb.ac.cn.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cell Line
+ *Diet, High-Fat
+ Disease Susceptibility
+ *Fatty Liver/et [Etiology]
+ *Fatty Liver/me [Metabolism]
+ Fatty Liver/pa [Pathology]
+ Gene Expression
+ Gene Expression Profiling
+ Gene Knockdown Techniques
+ Gene Targeting
+ Hedgehog Proteins/me [Metabolism]
+ Hepatocytes/me [Metabolism]
+ Hepatocytes/pa [Pathology]
+ Humans
+ Immunohistochemistry
+ Mice
+ Mice, Knockout
+ Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ PPAR gamma/me [Metabolism]
+ Protein Binding
+ *RNA, Long Noncoding/ge [Genetics]
+ RNA-Binding Proteins
+ Signal Transduction
+Abstract
+ The Hedgehog (Hh) signalling pathway plays a critical role in regulating liver lipid metabolism and related diseases. However, the underlying mechanisms are poorly understood. Here, we show that the Hh signalling pathway induces a previously undefined long non-coding RNA (Hilnc, Hedgehog signalling-induced long non-coding RNA), which controls hepatic lipid metabolism. Mutation of the Gli-binding sites in the Hilnc promoter region (HilncBM/BM) decreases the expression of Hilnc in vitro and in vivo. HilncBM/BM and Hilnc-knockout mice are resistant to diet-induced obesity and hepatic steatosis through attenuation of the peroxisome proliferator-activated receptor signalling pathway, as Hilnc directly interacts with IGF2BP2 to enhance Ppargamma mRNA stability. Furthermore, we identify a potential functional human homologue of Hilnc, h-Hilnc, which has a similar function in regulating cellular lipid metabolism. These findings uncover a critical role of the Hh-Hilnc-IGF2BP2 signalling axis in lipid metabolism and suggest a potential therapeutic target for the treatment of diet-induced hepatic steatosis. Copyright © 2021. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hedgehog Proteins). 0 (IGF2BP2 protein, mouse). 0 (PPAR gamma). 0 (RNA, Long Noncoding). 0 (RNA-Binding Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs42255-021-00488-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jiang&issn=2522-5812&title=Nature+Metabolism&atitle=Loss+of+Hilnc+prevents+diet-induced+hepatic+steatosis+through+binding+of+IGF2BP2.&volume=3&issue=11&spage=1569&epage=1584&date=2021&doi=10.1038%2Fs42255-021-00488-3&pmid=34750570&sid=OVID:medline
+
+<707>
+Unique Identifier
+ 34740110
+Title
+ Impact of combined consumption of fish oil and probiotics on the serum metabolome in pregnant women with overweight or obesity.
+Source
+ EBioMedicine. 73:103655, 2021 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mokkala K; Vahlberg T; Houttu N; Koivuniemi E; Lahti L; Laitinen K
+Authors Full Name
+ Mokkala, Kati; Vahlberg, Tero; Houttu, Noora; Koivuniemi, Ella; Lahti, Leo; Laitinen, Kirsi.
+Institution
+ Mokkala, Kati. Institute of Biomedicine, Integrative Physiology and Pharmacology, 20014 University of Turku, Turku, Finland. Electronic address: kirsi.laitinen@utu.fi.
+ Vahlberg, Tero. Institute of Clinical Medicine, Biostatistics, 20014 University of Turku, Turku, Finland.
+ Houttu, Noora. Institute of Biomedicine, Integrative Physiology and Pharmacology, 20014 University of Turku, Turku, Finland.
+ Koivuniemi, Ella. Institute of Biomedicine, Integrative Physiology and Pharmacology, 20014 University of Turku, Turku, Finland.
+ Lahti, Leo. Department of Computing, 20014 University of Turku, Turku, Finland.
+ Laitinen, Kirsi. Institute of Biomedicine, Integrative Physiology and Pharmacology, 20014 University of Turku, Turku, Finland; Department of Obstetrics and Gynecology, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland. Electronic address: kirsi.laitinen@utu.fi.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Computational Biology/mt [Methods]
+ Dietary Supplements
+ Female
+ *Fish Oils/ad [Administration & Dosage]
+ Humans
+ *Metabolome
+ Metabolomics/mt [Methods]
+ *Obesity/bl [Blood]
+ *Overweight/bl [Blood]
+ Pregnancy
+ *Pregnant Women
+ *Probiotics/ad [Administration & Dosage]
+Keyword Heading
+ Fish oil
+ Gestational diabetes
+ Intervention
+ Metabolomics
+ Probiotics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: If a pregnant woman is overweight, this can evoke metabolic alterations that may have health consequences for both mother and child.
+
+ METHODS: Pregnant women with overweight/obesity (n = 358) received fish oil+placebo, probiotics+placebo, fish oil+probiotics or placebo+placebo from early pregnancy onwards. The serum metabolome was analysed from fasting samples with a targeted NMR-approach in early and late pregnancy. GDM was diagnosed by OGTT.
+
+ FINDINGS: The intervention changed the metabolic profile of the women, but the effect was influenced by their GDM status. In women without GDM, the changes in nine lipids (FDR<0.05) in the fish oil+placebo-group differed when compared to the placebo+placebo-group. The combination of fish oil and probiotics induced changes in more metabolites, 46 of the lipid metabolites differed in women without GDM when compared to placebo+placebo-group; these included reduced increases in the concentrations and lipid constituents of VLDL-particles and less pronounced alterations in the ratios of various lipids in several lipoproteins. In women with GDM, no differences were detected in the changes of any metabolites due to any of the interventions when compared to the placebo+placebo-group (FDR<0.05).
+
+ INTERPRETATION: Fish oil and particularly the combination of fish oil and probiotics modified serum lipids in pregnant women with overweight or obesity, while no such effects were seen with probiotics alone. The effects were most evident in the lipid contents of VLDL and LDL only in women without GDM.
+
+ FUNDING: State Research Funding for university-level health research in the Turku University Hospital Expert Responsibility Area, Academy of Finland, the Diabetes Research Foundation, the Juho Vainio Foundation, Janssen Research & Development, LLC. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fish Oils).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.ebiom.2021.103655
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mokkala&issn=2352-3964&title=EBioMedicine&atitle=Impact+of+combined+consumption+of+fish+oil+and+probiotics+on+the+serum+metabolome+in+pregnant+women+with+overweight+or+obesity.&volume=73&issue=&spage=103655&epage=&date=2021&doi=10.1016%2Fj.ebiom.2021.103655&pmid=34740110&sid=OVID:medline
+
+<708>
+Unique Identifier
+ 34715355
+Title
+ Proximity Extension Assay in Combination with Next-Generation Sequencing for High-throughput Proteome-wide Analysis.
+Source
+ Molecular & Cellular Proteomics. 20:100168, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wik L; Nordberg N; Broberg J; Bjorkesten J; Assarsson E; Henriksson S; Grundberg I; Pettersson E; Westerberg C; Liljeroth E; Falck A; Lundberg M
+Authors Full Name
+ Wik, Lotta; Nordberg, Niklas; Broberg, John; Bjorkesten, Johan; Assarsson, Erika; Henriksson, Sara; Grundberg, Ida; Pettersson, Erik; Westerberg, Christina; Liljeroth, Elin; Falck, Adam; Lundberg, Martin.
+Institution
+ Wik, Lotta. Olink Proteomics, Uppsala, Sweden. Electronic address: lotta.wik@olink.com.
+ Nordberg, Niklas. Olink Proteomics, Uppsala, Sweden.
+ Broberg, John. Olink Proteomics, Uppsala, Sweden.
+ Bjorkesten, Johan. Olink Proteomics, Uppsala, Sweden.
+ Assarsson, Erika. Olink Proteomics, Uppsala, Sweden.
+ Henriksson, Sara. Olink Proteomics, Uppsala, Sweden.
+ Grundberg, Ida. Olink Proteomics, Uppsala, Sweden.
+ Pettersson, Erik. Olink Proteomics, Uppsala, Sweden.
+ Westerberg, Christina. Olink Proteomics, Uppsala, Sweden.
+ Liljeroth, Elin. Olink Proteomics, Uppsala, Sweden.
+ Falck, Adam. Olink Proteomics, Uppsala, Sweden.
+ Lundberg, Martin. Olink Proteomics, Uppsala, Sweden.
+MeSH Subject Headings
+ *Biological Assay
+ Biomarkers/bl [Blood]
+ High-Throughput Nucleotide Sequencing
+ Humans
+ Obesity/bl [Blood]
+ Proteome
+ *Proteomics
+Keyword Heading
+ antibody
+ biomarker
+ immunoassay
+ multiplex
+ next-generation sequencing
+ plasma
+ proteomics
+ proximity extension assay
+ serum
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Understanding the dynamics of the human proteome is crucial for developing biomarkers to be used as measurable indicators for disease severity and progression, patient stratification, and drug development. The Proximity Extension Assay (PEA) is a technology that translates protein information into actionable knowledge by linking protein-specific antibodies to DNA-encoded tags. In this report we demonstrate how we have combined the unique PEA technology with an innovative and automated sample preparation and high-throughput sequencing readout enabling parallel measurement of nearly 1500 proteins in 96 samples generating close to 150,000 data points per run. This advancement will have a major impact on the discovery of new biomarkers for disease prediction and prognosis and contribute to the development of the rapidly evolving fields of wellness monitoring and precision medicine. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteome).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.mcpro.2021.100168
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wik&issn=1535-9476&title=Molecular+%26+Cellular+Proteomics&atitle=Proximity+Extension+Assay+in+Combination+with+Next-Generation+Sequencing+for+High-throughput+Proteome-wide+Analysis.&volume=20&issue=&spage=100168&epage=&date=2021&doi=10.1016%2Fj.mcpro.2021.100168&pmid=34715355&sid=OVID:medline
+
+<709>
+Unique Identifier
+ 34707566
+Title
+ LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families.
+Source
+ Frontiers in Endocrinology. 12:656077, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shi SQ; Li SS; Zhang XY; Wei Z; Fu WZ; He JW; Hu YQ; Li M; Zheng LL; Zhang ZL
+Authors Full Name
+ Shi, Su-Qin; Li, Shan-Shan; Zhang, Xiao-Ya; Wei, Zhe; Fu, Wen-Zhen; He, Jin-Wei; Hu, Yun-Qiu; Li, Miao; Zheng, Li-Li; Zhang, Zhen-Lin.
+Institution
+ Shi, Su-Qin. Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
+ Shi, Su-Qin. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Li, Shan-Shan. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Zhang, Xiao-Ya. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Wei, Zhe. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Fu, Wen-Zhen. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ He, Jin-Wei. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Hu, Yun-Qiu. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Li, Miao. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Zheng, Li-Li. Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
+ Zhang, Zhen-Lin. Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Bone Density
+ China/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Genetic Association Studies
+ *Haplotypes
+ Humans
+ Linkage Disequilibrium
+ Male
+ Middle Aged
+ Nuclear Family
+ *Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ *Phenotype
+ *Polymorphism, Single Nucleotide
+ Prognosis
+ *Receptors, G-Protein-Coupled/ge [Genetics]
+Keyword Heading
+ LGR4
+ QTDT
+ SNP
+ fat mass
+ obesity
+ osteoporosis
+ peak bone mineral density
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: The current study was conducted to determine whether peak bone mineral density (BMD) and obesity phenotypes are associated with certain LGR4 gene polymorphisms found in Chinese nuclear families with female children.
+
+ Methods: A total of 22 single nucleotide polymorphisms (SNPs) located in and around the LGR4 gene were identified in 1,300 subjects who were members of 390 Chinese nuclear families with female children. Then, BMD readings of the femoral neck, total hip, and lumbar spine as well as measurements of the total lean mass (TLM), total fat mass (TFM), and trunk fat mass were obtained via dual-energy X-ray absorptiometry. The quantitative transmission disequilibrium test was used to analyze the associations between specific SNPs and LGR4 haplotypes and peak BMD as well as between LGR4 haplotypes and TLM, percent lean mass, TFM, percent fat mass, trunk fat mass, and body mass index (BMI).
+
+ Results: Here, rs7936621 was significantly associated with the BMD values for the total hip and lumbar spine, while rs10835171 and rs6484295 were associated with the trunk fat mass and BMI, respectively. Regarding the haplotypes, we found significant associations between GAA in block 2 and trunk fat mass and BMI, between AGCGT in block 3 and total hip BMD, between TGCTCC in block 5 and femoral neck BMD, and between TACTTC in block 5 and both lumbar spine and femoral neck BMD (all P-values < 0.05).
+
+ Conclusion: Genetic variations of the LGR4 gene are related to peak BMD, BMI, and trunk fat mass. Copyright © 2021 Shi, Li, Zhang, Wei, Fu, He, Hu, Li, Zheng and Zhang.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (LGR4 protein, human). 0 (Receptors, G-Protein-Coupled).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.656077
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shi&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=LGR4+Gene+Polymorphisms+Are+Associated+With+Bone+and+Obesity+Phenotypes+in+Chinese+Female+Nuclear+Families.&volume=12&issue=&spage=656077&epage=&date=2021&doi=10.3389%2Ffendo.2021.656077&pmid=34707566&sid=OVID:medline
+
+<710>
+Unique Identifier
+ 34704358
+Title
+ MicroRNA-150 and its target ETS-domain transcription factor 1 contribute to inflammation in diabetic photoreceptors.
+Source
+ Journal of Cellular & Molecular Medicine. 25(22):10724-10735, 2021 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yu F; Ko ML; Ko GY
+Author NameID
+ Ko, Gladys Y-P; ORCID: https://orcid.org/0000-0002-6854-777X
+Authors Full Name
+ Yu, Fei; Ko, Michael L; Ko, Gladys Y-P.
+Institution
+ Yu, Fei. Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
+ Ko, Michael L. Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
+ Ko, Michael L. Department of Biology, Division of Natural and Physical Sciences, Blinn College, Bryan, Texas, USA.
+ Ko, Gladys Y-P. Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
+ Ko, Gladys Y-P. Texas A&M Institute for Neuroscience, Texas A&M University, College Station, Texas, USA.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cell Line
+ Diabetes Mellitus, Type 2
+ *Diabetic Retinopathy/et [Etiology]
+ *Diabetic Retinopathy/me [Metabolism]
+ Diabetic Retinopathy/pa [Pathology]
+ Disease Models, Animal
+ Disease Susceptibility
+ Gene Expression Regulation
+ Male
+ Mice
+ Mice, Knockout
+ *MicroRNAs/ge [Genetics]
+ Obesity
+ *Photoreceptor Cells/me [Metabolism]
+ Photoreceptor Cells/pa [Pathology]
+ RNA Interference
+ *ets-Domain Protein Elk-1/ge [Genetics]
+Keyword Heading
+ diabetes
+ diabetic retinopathy
+ inflammation
+ microRNA
+ obesity
+ photoreceptor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity-associated type 2 diabetes (T2D) is on the rise in the United States due to the obesity epidemic, and 60% of T2D patients develop diabetic retinopathy (DR) in their lifetime. Chronic inflammation is a hallmark of obesity and T2D and a well-accepted major contributor to DR, and retinal photoreceptors are a major source of intraocular inflammation and directly contribute to vascular abnormalities in diabetes. However, how diabetic insults cause photoreceptor inflammation is not well known. In this study, we used a high-fat diet (HFD)-induced T2D mouse model and cultured photoreceptors treated with palmitic acid (PA) to decipher major players that mediate high-fat-induced photoreceptor inflammation. We found that PA-elicited microRNA-150 (miR-150) decreases with a consistent upregulation of ETS-domain transcription factor 1 (Elk1), a downstream target of miR-150, in PA-elicited photoreceptor inflammation. We compared wild-type (WT) and miR-150 null (miR-150-/- ) mice fed with an HFD and found that deletion of miR-150 exacerbated HFD-induced photoreceptor inflammation in conjunction with upregulated ELK1. We further delineated the critical cellular localization of phosphorylated ELK1 at serine 383 (pELK1S383 ) and found that decreased miR-150 exacerbated the T2D-induced inflammation in photoreceptors by upregulating ELK1 and pELK1S383 , and knockdown of ELK1 alleviated PA-elicited photoreceptor inflammation. Copyright © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Elk1 protein, mouse). 0 (MicroRNAs). 0 (Mirn150 microRNA, mouse). 0 (ets-Domain Protein Elk-1).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1111%2fjcmm.17012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yu&issn=1582-1838&title=Journal+of+Cellular+%26+Molecular+Medicine&atitle=MicroRNA-150+and+its+target+ETS-domain+transcription+factor+1+contribute+to+inflammation+in+diabetic+photoreceptors.&volume=25&issue=22&spage=10724&epage=10735&date=2021&doi=10.1111%2Fjcmm.17012&pmid=34704358&sid=OVID:medline
+
+<711>
+Unique Identifier
+ 34698104
+Title
+ Impact of Vitamin D Supplementation on Inflammatory Markers' Levels in Obese Patients.
+Source
+ Current Issues in Molecular Biology. 43(3):1606-1622, 2021 Oct 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wicinski M; Ozorowski M; Wodkiewicz E; Otto SW; Kubiak K; Malinowski B
+Author NameID
+ Ozorowski, Mateusz; ORCID: https://orcid.org/0000-0003-3401-8738
+ Wodkiewicz, Eryk; ORCID: https://orcid.org/0000-0002-2834-3414
+Authors Full Name
+ Wicinski, Michal; Ozorowski, Mateusz; Wodkiewicz, Eryk; Otto, Stephan Walter; Kubiak, Karol; Malinowski, Bartosz.
+Institution
+ Wicinski, Michal. Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
+ Ozorowski, Mateusz. Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
+ Wodkiewicz, Eryk. Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
+ Otto, Stephan Walter. Department of Urology, Raphaelsklinik, 48143 Munster, Germany.
+ Kubiak, Karol. Department of Obstetrics and Gynecology, St. Franziskus-Hospital, 48145 Munster, Germany.
+ Malinowski, Bartosz. Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ Body Weights and Measures
+ *Dietary Supplements
+ Disease Susceptibility
+ Female
+ *Health Impact Assessment
+ Humans
+ *Inflammation Mediators/bl [Blood]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/et [Etiology]
+ Organ Size
+ *Vitamin D/ad [Administration & Dosage]
+Keyword Heading
+ inflammation
+ obesity
+ pathways
+ pharmacology
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In view of research suggesting a possible beneficial impact of vitamin D on systemic inflammatory response, the authors decided to investigate an influence of vitamin D supplementation on serum levels of certain inflammatory markers in obese patients. The current study included such biomarkers as interleukin-6 (IL-6), pituitary adenylate cyclase-activating peptide (PACAP), advanced oxidation protein products (AOPP), C-X3-C Motif Chemokine Ligand 1 (CX3CL1), monocyte chemoattractant protein-1 (MCP-1), and nitric oxide (NO). The measurements were performed with the ELISA method before and after 3-month-long supplementation of 2000 IU of vitamin D orally. The results showed that the therapy did not induce any statistically significant changes in serum levels of MCP-1, IL-6, CX3CL1, and PACAP. The supplementation was related to a significant increase in measurements of NO and AOPP levels, although the correlation analysis between vitamin D concentration after its supplementation and the concentration of the molecular parameters did not show significant relation. In conclusion, our study seems to contradict certain aspects of findings available in the literature regarding the vitamin D's impact.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fcimb43030114
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wicinski&issn=1467-3037&title=Current+Issues+in+Molecular+Biology&atitle=Impact+of+Vitamin+D+Supplementation+on+Inflammatory+Markers%27+Levels+in+Obese+Patients.&volume=43&issue=3&spage=1606&epage=1622&date=2021&doi=10.3390%2Fcimb43030114&pmid=34698104&sid=OVID:medline
+
+<712>
+Unique Identifier
+ 34698087
+Title
+ Molecular Profiling of DNA Methylation and Alternative Splicing of Genes in Skeletal Muscle of Obese Rabbits.
+Source
+ Current Issues in Molecular Biology. 43(3):1558-1575, 2021 Oct 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li Y; Wang J; Elzo MA; Fan H; Du K; Xia S; Shao J; Lai T; Hu S; Jia X; Lai S
+Author NameID
+ Wang, Jie; ORCID: https://orcid.org/0000-0002-1399-7079
+ Jia, Xianbo; ORCID: https://orcid.org/0000-0002-6885-4104
+Authors Full Name
+ Li, Yanhong; Wang, Jie; Elzo, Mauricio A; Fan, Huimei; Du, Kun; Xia, Siqi; Shao, Jiahao; Lai, Tianfu; Hu, Shenqiang; Jia, Xianbo; Lai, Songjia.
+Institution
+ Li, Yanhong. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Wang, Jie. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Elzo, Mauricio A. Department of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
+ Fan, Huimei. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Du, Kun. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Xia, Siqi. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Shao, Jiahao. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Lai, Tianfu. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Hu, Shenqiang. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Jia, Xianbo. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+ Lai, Songjia. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
+MeSH Subject Headings
+ *Alternative Splicing
+ Animals
+ Biomarkers
+ Computational Biology/mt [Methods]
+ CpG Islands
+ *DNA Methylation
+ Diet, High-Fat
+ Disease Susceptibility
+ Energy Metabolism
+ Epigenesis, Genetic
+ Exons
+ *Gene Expression Profiling
+ *Gene Expression Regulation
+ High-Throughput Nucleotide Sequencing
+ *Muscle, Skeletal/me [Metabolism]
+ *Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Rabbits
+ *Transcriptome
+Keyword Heading
+ DNA methylation
+ alternative splicing
+ metabolic network
+ rabbit
+ skeletal muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ DNA methylation and the alternative splicing of precursor messenger RNAs (pre-mRNAs) are two important genetic modification mechanisms. However, both are currently uncharacterized in the muscle metabolism of rabbits. Thus, we constructed the Tianfu black rabbit obesity model (obese rabbits fed with a 10% high-fat diet and control rabbits from 35 days to 70 days) and collected the skeletal muscle samples from the two groups for Genome methylation sequencing and RNA sequencing. DNA methylation data showed that the promoter regions of 599 genes and gene body region of 2522 genes had significantly differential methylation rates between the two groups, of which 288 genes had differential methylation rates in promoter and gene body regions. Analysis of alternative splicing showed 555 genes involved in exon skipping (ES) patterns, and 15 genes existed in differential methylation regions. Network analysis showed that 20 hub genes were associated with ubiquitinated protein degradation, muscle development pathways, and skeletal muscle energy metabolism. Our findings suggest that the two types of genetic modification have potential regulatory effects on skeletal muscle development and provide a basis for further mechanistic studies in the rabbit.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fcimb43030110
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1467-3037&title=Current+Issues+in+Molecular+Biology&atitle=Molecular+Profiling+of+DNA+Methylation+and+Alternative+Splicing+of+Genes+in+Skeletal+Muscle+of+Obese+Rabbits.&volume=43&issue=3&spage=1558&epage=1575&date=2021&doi=10.3390%2Fcimb43030110&pmid=34698087&sid=OVID:medline
+
+<713>
+Unique Identifier
+ 34696714
+Title
+ Circulating adipsin is associated with asymptomatic carotid atherosclerosis in obese adults.
+Source
+ BMC Cardiovascular Disorders. 21(1):517, 2021 10 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang J; Teng F; Pan L; Guo D; Liu J; Li K; Yuan Y; Li W; Zhang H
+Authors Full Name
+ Zhang, Jinhua; Teng, Fei; Pan, Lingling; Guo, Dan; Liu, Jianfang; Li, Kangli; Yuan, Youwen; Li, Wenyuan; Zhang, Huijie.
+Institution
+ Zhang, Jinhua. Key Laboratory of Functional and Clinical Translational Medicine, Department of General Medicine, Xiamen Medical College, Xiamen, China.
+ Teng, Fei. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Road, Guangzhou, 510515, China.
+ Teng, Fei. The First Affiliated Hospital of Xiamen University, Xiamen, China.
+ Pan, Lingling. Department of Endocrinology and Metabolism, Tongji Hospital, Tongji University, Shanghai, China.
+ Guo, Dan. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Road, Guangzhou, 510515, China.
+ Liu, Jianfang. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Road, Guangzhou, 510515, China.
+ Li, Kangli. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Road, Guangzhou, 510515, China.
+ Yuan, Youwen. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Road, Guangzhou, 510515, China.
+ Li, Wenyuan. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Road, Guangzhou, 510515, China. liwy666@163.com.
+ Zhang, Huijie. Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Road, Guangzhou, 510515, China. huijiezhang2005@126.com.
+ Zhang, Huijie. The First Affiliated Hospital of Xiamen University, Xiamen, China. huijiezhang2005@126.com.
+ Zhang, Huijie. Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. huijiezhang2005@126.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Carotid Artery Diseases/bl [Blood]
+ *Carotid Artery Diseases/co [Complications]
+ *Carotid Intima-Media Thickness
+ *Complement Factor D/an [Analysis]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+Keyword Heading
+ Adipsin
+ Asymptomatic carotid atherosclerosis
+ Cardiovascular disease
+ Carotid intima-media thickness
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Adipsin has been identified as a secreted adipokine that plays a critical pathogenic role in metabolic disorders. However, it is not clear regarding the association of circulating adipsin with cardiovascular disease (CVD). This study will explore the association between circulating adipsin and asymptomatic carotid atherosclerosis in Chinese obese adults.
+
+ METHODS: A total of 483 obese adult subjects (aged 40 years or older) were enrolled in this study. Serum adipsin concentrations and carotid intima-media thickness (CIMT) were measured to determine these associations.
+
+ RESULTS: Individuals with increased CIMT and asymptomatic carotid atherosclerosis had lower levels of circulating adipsin than controls (both p < 0.05). The prevalence of asymptomatic carotid atherosclerosis was significantly higher in subjects with lower levels of serum adipsin than those with higher values (42.5% vs. 36.7%, p < 0.05). Notably, subjects in the lowest quartile of serum adipsin were 1.94 times (p = 0.059) more likely to have increased CIMT and 2.91 times (p = 0.03) more likely to have asymptomatic carotid atherosclerosis than those in the highest quartile in multivariable logistic regression analyses, adjusting for age, gender, current smoking, alcohol consumption, physical activity, BMI, systolic BP, fasting glucose, total cholesterol, HDL-c, and HOMA-IR. However, such associations with circulating adipsin were not noted for atherosclerotic plaque.
+
+ CONCLUSIONS: These findings suggest that circulating adipsin concentrations are a potential marker of risks of increased CIMT and asymptomatic carotid atherosclerosis in obese Chinese adults. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4-21-46 (CFD protein, human). EC 3-4-21-46 (Complement Factor D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12872-021-02329-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Circulating+adipsin+is+associated+with+asymptomatic+carotid+atherosclerosis+in+obese+adults.&volume=21&issue=1&spage=517&epage=&date=2021&doi=10.1186%2Fs12872-021-02329-3&pmid=34696714&sid=OVID:medline
+
+<714>
+Unique Identifier
+ 34685582
+Title
+ Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation.
+Source
+ Cells. 10(10), 2021 09 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kochumon S; Arefanian H; Sindhu S; Shenouda S; Thomas R; Al-Mulla F; Tuomilehto J; Ahmad R
+Author NameID
+ Arefanian, Hossein; ORCID: https://orcid.org/0000-0001-6414-0916
+ Sindhu, Sardar; ORCID: https://orcid.org/0000-0001-9936-1575
+ Al-Mulla, Fahd; ORCID: https://orcid.org/0000-0001-5409-3829
+ Ahmad, Rasheed; ORCID: https://orcid.org/0000-0001-5746-0743
+Authors Full Name
+ Kochumon, Shihab; Arefanian, Hossein; Sindhu, Sardar; Shenouda, Steve; Thomas, Reeby; Al-Mulla, Fahd; Tuomilehto, Jaakko; Ahmad, Rasheed.
+Institution
+ Kochumon, Shihab. Department of Immunology & Microbiology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Arefanian, Hossein. Department of Immunology & Microbiology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Sindhu, Sardar. Animal and Imaging Core Facilities, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Shenouda, Steve. Department of Immunology & Microbiology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Thomas, Reeby. Department of Immunology & Microbiology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Al-Mulla, Fahd. Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+ Tuomilehto, Jaakko. Department of Public Health, University of Helsinki, 00100 Helsinki, Finland.
+ Tuomilehto, Jaakko. Public Health Promotion Unit, Diabetes Research Group, Finnish Institute for Health and Welfare, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
+ Ahmad, Rasheed. Department of Immunology & Microbiology, Dasman Diabetes Institute, Dasman 15462, Kuwait.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ *Carrier Proteins/me [Metabolism]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Humans
+ *Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ *Insulin Resistance/ph [Physiology]
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+Keyword Heading
+ adipose tissue
+ inflammation
+ insulin resistance
+ obesity
+ steroid receptor RNA activator 1/SRA1
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Steroid receptor RNA activator 1 (SRA1) is involved in pathophysiological responses of adipose tissue (AT) in obesity. In vitro and animal studies have elucidated its role in meta-inflammation. Since SRA1 AT expression in obesity/type 2 diabetes (T2D) and the relationship with immune-metabolic signatures remains unclear, we assessed AT SRA1 expression and its association with immune-metabolic markers in individuals with obesity/T2D. For this, 55 non-diabetic and 53 T2D individuals classified as normal weight (NW; lean), overweight, and obese were recruited and fasting blood and subcutaneous fat biopsy samples were collected. Plasma metabolic markers were assessed using commercial kits and AT expression of SRA1 and selected immune markers using RT-qPCR. SRA1 expression was significantly higher in non-diabetic obese compared with NW individuals. SRA1 expression associated with BMI, PBF, serum insulin, and HOMA-IR in the total study population and people without diabetes. SRA1 associated with waist circumference in people without diabetes and NW participants, whereas it associated inversely with HbA1c in overweight participants. In most study subgroups AT SRA1 expression associated directly with CXCL9, CXCL10, CXCL11, TNF-alpha, TGF-beta, IL2RA, and IL18, but inversely with CCL19 and CCR2. TGF-beta/IL18 independently predicted the SRA1 expression in people without diabetes and in the total study population, while TNF-alpha/IL-2RA predicted SRA1 only in people with diabetes. TNF-alpha also predicted SRA1 in both NW and obese people regardless of the diabetes status. In conclusion, AT SRA1 expression is elevated in people with obesity which associates with typical immunometabolic markers of obesity/T2D, implying that SRA1 may have potential as a biomarker of metabolic derangements.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Carrier Proteins). 0 (steroid receptor RNA activator, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fcells10102602
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kochumon&issn=2073-4409&title=Cells&atitle=Adipose+Tissue+Steroid+Receptor+RNA+Activator+1+%28SRA1%29+Expression+Is+Associated+with+Obesity%2C+Insulin+Resistance%2C+and+Inflammation.&volume=10&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fcells10102602&pmid=34685582&sid=OVID:medline
+
+<715>
+Unique Identifier
+ 34684621
+Title
+ The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial.
+Source
+ Nutrients. 13(10), 2021 Oct 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Miller L; Thompson K; Pavlenco C; Mettu VS; Haverkamp H; Skaufel S; Basit A; Prasad B; Larsen J
+Author NameID
+ Miller, Lindsey; ORCID: https://orcid.org/0000-0002-4706-7670
+ Thompson, Kari; ORCID: https://orcid.org/0000-0002-9082-9319
+ Pavlenco, Carolina; ORCID: https://orcid.org/0000-0002-3864-603X
+ Basit, Abdul; ORCID: https://orcid.org/0000-0002-1164-5520
+Authors Full Name
+ Miller, Lindsey; Thompson, Kari; Pavlenco, Carolina; Mettu, Vijaya Saradhi; Haverkamp, Hans; Skaufel, Samantha; Basit, Abdul; Prasad, Bhagwat; Larsen, Julie.
+Institution
+ Miller, Lindsey. Department of Physiology, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Knoxville, TN 37934, USA.
+ Miller, Lindsey. Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
+ Thompson, Kari. Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
+ Pavlenco, Carolina. Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
+ Mettu, Vijaya Saradhi. Department of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
+ Haverkamp, Hans. Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
+ Skaufel, Samantha. Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
+ Basit, Abdul. Department of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
+ Prasad, Bhagwat. Department of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
+ Larsen, Julie. Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ *Cholesterol, HDL/bl [Blood]
+ Diet
+ Dimethyl Sulfoxide/bl [Blood]
+ *Dimethyl Sulfoxide/pd [Pharmacology]
+ Exercise
+ Female
+ Fibrosis
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/pa [Pathology]
+ Male
+ *Obesity/bl [Blood]
+ Oxidation-Reduction
+ Sulfones/bl [Blood]
+ *Sulfones/pd [Pharmacology]
+Keyword Heading
+ cardiometabolic
+ inflammation
+ methylsulfonylmethane
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Interventions to decrease inflammation and improve metabolic function hold promise for the prevention of obesity-related diseases. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory effects. Improvements in measures of metabolic health have been observed in mouse models of obesity and diabetes following MSM treatment. However, the effects of MSM on obesity-related diseases in humans have not been investigated. Therefore, the purpose of this investigation was to determine whether MSM supplementation improves cardiometabolic health, and markers of inflammation and oxidative status. A randomized, double-blind, placebo-controlled design was utilized with a total of 22 overweight or obese adults completing the study. Participants received either a placebo (white rice flour) or 3 g MSM daily for 16 weeks. Measurements occurred at baseline and after 4, 8, and 16 weeks. Outcome measures included fasting glucose, insulin, blood lipids, blood pressure, body composition, metabolic rate, and markers of inflammation and oxidative status. The primary finding of this work shows that high-density lipoprotein cholesterol was elevated at 8 and 16 weeks of daily MSM consumption compared to baseline, (p = 0.008, p = 0.013). Our findings indicate that MSM supplementation may improve the cholesterol profile by resulting in higher levels of high-density lipoprotein cholesterol.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Sulfones). 9007-41-4 (C-Reactive Protein). 9H4PO4Z4FT (dimethyl sulfone). YOW8V9698H (Dimethyl Sulfoxide).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13103620
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Miller&issn=2072-6643&title=Nutrients&atitle=The+Effect+of+Daily+Methylsulfonylmethane+%28MSM%29+Consumption+on+High-Density+Lipoprotein+Cholesterol+in+Healthy+Overweight+and+Obese+Adults%3A+A+Randomized+Controlled+Trial.&volume=13&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fnu13103620&pmid=34684621&sid=OVID:medline
+
+<716>
+Unique Identifier
+ 34684461
+Title
+ New Insights on the PBMCs Phospholipidome in Obesity Demonstrate Modulations Associated with Insulin Resistance and Glycemic Status.
+Source
+ Nutrients. 13(10), 2021 Sep 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wilkin C; Colonval M; Dehairs J; Esser N; Iovino M; Gianfrancesco MA; Fadeur M; Swinnen JV; Paquot N; Piette J; Legrand-Poels S
+Author NameID
+ Wilkin, Chloe; ORCID: https://orcid.org/0000-0002-7743-3926
+ Dehairs, Jonas; ORCID: https://orcid.org/0000-0002-6789-2264
+ Esser, Nathalie; ORCID: https://orcid.org/0000-0003-1823-3817
+Authors Full Name
+ Wilkin, Chloe; Colonval, Megan; Dehairs, Jonas; Esser, Nathalie; Iovino, Margaud; Gianfrancesco, Marco A; Fadeur, Marjorie; Swinnen, Johan V; Paquot, Nicolas; Piette, Jacques; Legrand-Poels, Sylvie.
+Institution
+ Wilkin, Chloe. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+ Colonval, Megan. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+ Dehairs, Jonas. Laboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
+ Esser, Nathalie. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+ Esser, Nathalie. Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, University Hospital of Liege, 4000 Liege, Belgium.
+ Iovino, Margaud. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+ Gianfrancesco, Marco A. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+ Gianfrancesco, Marco A. Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, University Hospital of Liege, 4000 Liege, Belgium.
+ Fadeur, Marjorie. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+ Fadeur, Marjorie. Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, University Hospital of Liege, 4000 Liege, Belgium.
+ Swinnen, Johan V. Laboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
+ Paquot, Nicolas. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+ Paquot, Nicolas. Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, University Hospital of Liege, 4000 Liege, Belgium.
+ Piette, Jacques. Laboratory of Virology and Immunology, GIGA-Molecular Biology of Diseases, University of Liege, 4000 Liege, Belgium.
+ Legrand-Poels, Sylvie. Laboratory of Immunometabolism and Nutrition, GIGA-Inflammation, Infection & Immunity, University of Liege, 4000 Liege, Belgium.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ *Blood Glucose
+ Body Weights and Measures
+ Computational Biology
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ *Insulin Resistance
+ *Leukocytes, Mononuclear/me [Metabolism]
+ Lipidomics/mt [Methods]
+ *Lipidomics
+ Male
+ Mass Spectrometry
+ Membrane Lipids
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Phospholipids/me [Metabolism]
+ Young Adult
+Keyword Heading
+ immunology
+ lipidomic
+ membrane lipids
+ metabolism
+ obesity
+ phospholipids
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ (1) Background: Obesity and type 2 diabetes have been suspected to impact both intrinsic metabolism and function of circulating immune cells. (2) Methods: To further investigate this immunometabolic modulation, we profiled the phospholipidome of the peripheral blood mononuclear cells (PBMCs) in lean, normoglycemic obese (OBNG) and obese with dysglycemia (OBDysG) individuals. (3) Results: The global PBMCs phospholipidome is significantly downmodulated in OBDysG unlike OBNG patients when compared to lean ones. Multiple linear regression analyses show a strong negative relationship between the global PBMCs phospholipidome and parameters assessing insulin resistance. Even though all classes of phospholipid are affected, the relative abundance of each class is maintained with the exception of Lyso-PC/PC and Lyso-PE/PE ratios that are downmodulated in PBMCs of OBDysG compared to OBNG individuals. Interestingly, the percentage of saturated PC is positively associated with glycated hemoglobin (HbA1c). Moreover, a few lipid species are significantly downmodulated in PBMCs of OBDysG compared to OBNG individuals, making possible to distinguish the two phenotypes. (4) Conclusions: This lipidomic study highlights for the first-time modulations of the PBMCs phospholipidome in obese patients with prediabetes and type 2 diabetes. Such phospholipidome remodeling could disrupt the cell membranes and the lipid mediator's levels, driving an immune cell dysfunction.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Membrane Lipids). 0 (Phospholipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13103461
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wilkin&issn=2072-6643&title=Nutrients&atitle=New+Insights+on+the+PBMCs+Phospholipidome+in+Obesity+Demonstrate+Modulations+Associated+with+Insulin+Resistance+and+Glycemic+Status.&volume=13&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fnu13103461&pmid=34684461&sid=OVID:medline
+
+<717>
+Unique Identifier
+ 34684445
+Title
+ Craniopharyngioma, Chronotypes and Metabolic Risk Profile.
+Source
+ Nutrients. 13(10), 2021 Sep 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Di Somma C; Scarano E; Barrea L; Solari D; Riccio E; Arianna R; Cavallo LM; Romano F; Di Benedetto E; Rodriguez A; de Alteriis G; Colao A
+Author NameID
+ Barrea, Luigi; ORCID: https://orcid.org/0000-0001-9054-456X
+ Solari, Domenico; ORCID: https://orcid.org/0000-0003-1535-8737
+Authors Full Name
+ Di Somma, Carolina; Scarano, Elisabetta; Barrea, Luigi; Solari, Domenico; Riccio, Enrico; Arianna, Rossana; Cavallo, Luigi Maria; Romano, Fiammetta; Di Benedetto, Elea; Rodriguez, Alice; de Alteriis, Giulia; Colao, Annamaria.
+Institution
+ Di Somma, Carolina. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Di Somma, Carolina. Cattedra Unesco "Educazione Alla Salute e allo Sviluppo Sostenibile", Federico II University, 80131 Naples, Italy.
+ Scarano, Elisabetta. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Barrea, Luigi. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Solari, Domenico. Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, 80125 Naples, Italy.
+ Riccio, Enrico. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Arianna, Rossana. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Cavallo, Luigi Maria. Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, 80125 Naples, Italy.
+ Romano, Fiammetta. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Di Benedetto, Elea. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Rodriguez, Alice. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ de Alteriis, Giulia. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Colao, Annamaria. Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
+ Colao, Annamaria. Cattedra Unesco "Educazione Alla Salute e allo Sviluppo Sostenibile", Federico II University, 80131 Naples, Italy.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Blood Pressure
+ Body Weights and Measures
+ Case-Control Studies
+ *Circadian Rhythm
+ *Craniopharyngioma/et [Etiology]
+ *Craniopharyngioma/me [Metabolism]
+ Disease Susceptibility
+ *Energy Metabolism
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ chronotype
+ craniopharyngioma
+ hypothalamus
+ obesity
+ pituitary neoplasm
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To investigate the potential association among Craniopharyngioma (CP), chronotypes and metabolic risk profile.
+
+ SUBJECTS AND METHODS: The study population included 28 patients (46.4% males; 42.6 +/- 15.8 years) and 28 controls, age, gender and BMI matched (46.4% males; 46.5 +/- 12.9 years). In this study sample, we evaluated: anthropometric measurements (waist circumference, WC; BMI), plasma glucose, lipid profile, and systolic (SBP) and diastolic (DBP) blood pressure. Morningness-Eveningness was measured with the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ), which included 19 questions about preferred sleep time and daily performance.
+
+ RESULTS: in both patients and controls grade I obesity was detected in 15 subjects (53.6%), grade II obesity in 13 subjects (46.4%). In the patient group, the mean score of chronotype was 47.8 +/- 12.6. In particular, 9 patients (32.1%) exhibited the morning chronotype, 6 (21.4%) the intermediate chronotype and 13 (46.4.%) the evening chronotype. No significant difference was found in gender and age among the chronotype categories. Patients with the evening chronotype had higher blood pressure values and worse metabolic parameters than those with the morning chronotype. In the control group, the mean score of the chronotype was 57.6 +/- 9.5. In particular, 16 (57.1%) subjects exhibited the morning chronotype, 10 (35.7%) the intermediate chronotype and only 2 (7.1.%) the evening chronotype. The prevalence of intermediate and evening chronotypes was higher in females than males (p = 0.021), while males have a higher prevalence of the morning chronotype. Subjects with intermediate and evening chronotypes had worse metabolic parameters than those with the morning chronotype. In patients, the chronotype score was inversely correlated to WC, BMI, SBP, DBP, plasma glucose, total cholesterol, triglycerides, LDL cholesterol and positively correlated with HDL cholesterol. No correlation was found between age and chronotype. In controls, the chronotype score was inversely correlated to WC, BMI, plasma glucose, total cholesterol, LDL cholesterol. No correlation was found among chronotype and age, blood pressure, triglycerides, HDL cholesterol. Considering the whole population of the study (patients and controls), at logistic regression the chronotype score was significantly associated with the presence of CP.
+
+ CONCLUSIONS: for the first time thus far, our study puts the light on the association of the CP with chronotypes and metabolic alterations in this disease, which are the main determinants of the reduced quality of life, higher morbidity and mortality in this setting of patients. This finding suggests that alterations of chronotype might represent an adjunctive risk for CP patients and a possible target for their integrate management.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13103444
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Di+Somma&issn=2072-6643&title=Nutrients&atitle=Craniopharyngioma%2C+Chronotypes+and+Metabolic+Risk+Profile.&volume=13&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fnu13103444&pmid=34684445&sid=OVID:medline
+
+<718>
+Unique Identifier
+ 34684443
+Title
+ Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systematic Review and Meta-Analysis.
+Source
+ Nutrients. 13(10), 2021 Sep 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rodrigues C; Pinto A; Faria A; Teixeira D; van Wegberg AMJ; Ahring K; Feillet F; Calhau C; MacDonald A; Moreira-Rosario A; Rocha JC
+Author NameID
+ Rodrigues, Catarina; ORCID: https://orcid.org/0000-0003-4685-3562
+ Faria, Ana; ORCID: https://orcid.org/0000-0002-5165-9513
+ Teixeira, Diana; ORCID: https://orcid.org/0000-0002-2162-1450
+ van Wegberg, Annemiek M J; ORCID: https://orcid.org/0000-0002-9402-4833
+ Feillet, Francois; ORCID: https://orcid.org/0000-0002-8717-469X
+ Moreira-Rosario, Andre; ORCID: https://orcid.org/0000-0003-0320-1839
+ Rocha, Julio Cesar; ORCID: https://orcid.org/0000-0002-4977-8345
+Authors Full Name
+ Rodrigues, Catarina; Pinto, Alex; Faria, Ana; Teixeira, Diana; van Wegberg, Annemiek M J; Ahring, Kirsten; Feillet, Francois; Calhau, Conceicao; MacDonald, Anita; Moreira-Rosario, Andre; Rocha, Julio Cesar.
+Institution
+ Rodrigues, Catarina. Nutrition and Metabolism, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Rodrigues, Catarina. Comprehensive Health Research Centre, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Pinto, Alex. Dietetic Department, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.
+ Faria, Ana. Nutrition and Metabolism, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Faria, Ana. Comprehensive Health Research Centre, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Faria, Ana. CINTESIS-Center for Health Technology and Services Research, NOVA Medical School, Campo dos Martires da Patria 130, 1169-056 Lisboa, Portugal.
+ Teixeira, Diana. Nutrition and Metabolism, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Teixeira, Diana. Comprehensive Health Research Centre, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Teixeira, Diana. CINTESIS-Center for Health Technology and Services Research, NOVA Medical School, Campo dos Martires da Patria 130, 1169-056 Lisboa, Portugal.
+ van Wegberg, Annemiek M J. Division of Metabolic Diseases, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
+ Ahring, Kirsten. Department of PKU, Copenhagen University Hospital, DK-2600 Glostrup, Denmark.
+ Feillet, Francois. Department of Paediatrics, Reference Center for Inborn Errors of Metabolism, Hopital d'Enfants Brabois, CHU Nancy, 54500 Vandoeuvre les Nancy, France.
+ Calhau, Conceicao. Nutrition and Metabolism, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Calhau, Conceicao. CINTESIS-Center for Health Technology and Services Research, NOVA Medical School, Campo dos Martires da Patria 130, 1169-056 Lisboa, Portugal.
+ MacDonald, Anita. Dietetic Department, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.
+ Moreira-Rosario, Andre. Nutrition and Metabolism, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Moreira-Rosario, Andre. CINTESIS-Center for Health Technology and Services Research, NOVA Medical School, Campo dos Martires da Patria 130, 1169-056 Lisboa, Portugal.
+ Rocha, Julio Cesar. Nutrition and Metabolism, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
+ Rocha, Julio Cesar. CINTESIS-Center for Health Technology and Services Research, NOVA Medical School, Campo dos Martires da Patria 130, 1169-056 Lisboa, Portugal.
+ Rocha, Julio Cesar. Reference Centre of Inherited Metabolic Diseases, Centro Hospitalar Universitario de Lisboa Central, 1169-045 Lisboa, Portugal.
+MeSH Subject Headings
+ Age Factors
+ Biomarkers
+ *Diet/ae [Adverse Effects]
+ Diet Therapy/ae [Adverse Effects]
+ Disease Susceptibility
+ Eating
+ Humans
+ Nutrition Assessment
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ *Obesity/et [Etiology]
+ Overweight/di [Diagnosis]
+ *Overweight/ep [Epidemiology]
+ *Overweight/et [Etiology]
+ Phenylalanine/ad [Administration & Dosage]
+ *Phenylalanine/ae [Adverse Effects]
+ *Phenylketonurias/co [Complications]
+ Phenylketonurias/dh [Diet Therapy]
+ Publication Bias
+ Risk Factors
+Keyword Heading
+ body mass index
+ obesity
+ overweight
+ phenylalanine restriction
+ phenylalanine-restricted diet
+ phenylketonuria
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Although there is a general assumption that a phenylalanine (Phe)-restricted diet promotes overweight in patients with phenylketonuria (PKU), it is unclear if this presumption is supported by scientific evidence. This systematic review aimed to determine if patients with PKU are at a higher risk of overweight compared to healthy individuals. A literature search was carried out on PubMed, Cochrane Library, and Embase databases. Risk of bias of individual studies was assessed using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies, and the quality of the evidence for each outcome was assessed using the NutriGrade scoring system. From 829 articles identified, 15 were included in the systematic review and 12 in the meta-analysis. Body mass index (BMI) was similar between patients with PKU and healthy controls, providing no evidence to support the idea that a Phe-restricted diet is a risk factor for the development of overweight. However, a subgroup of patients with classical PKU had a significantly higher BMI than healthy controls. Given the increasing prevalence of overweight in the general population, patients with PKU require lifelong follow-up, receiving personalised nutritional counselling, with methodical nutritional status monitoring from a multidisciplinary team in inherited metabolic disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 47E5O17Y3R (Phenylalanine).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13103443
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rodrigues&issn=2072-6643&title=Nutrients&atitle=Is+the+Phenylalanine-Restricted+Diet+a+Risk+Factor+for+Overweight+or+Obesity+in+Patients+with+Phenylketonuria+%28PKU%29%3F+A+Systematic+Review+and+Meta-Analysis.&volume=13&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fnu13103443&pmid=34684443&sid=OVID:medline
+
+<719>
+Unique Identifier
+ 34684438
+Title
+ Effectiveness of a 6-Month Lifestyle Intervention on Diet, Physical Activity, Quality of Life, and Markers of Cardiometabolic Health in Women with PCOS and Obesity and Non-PCOS Obese Controls: One Size Fits All?.
+Source
+ Nutrients. 13(10), 2021 Sep 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang Z; Groen H; Cantineau AEP; van Elten TM; Karsten MDA; van Oers AM; Mol BWJ; Roseboom TJ; Hoek A
+Author NameID
+ Wang, Zheng; ORCID: https://orcid.org/0000-0003-1592-6765
+ Groen, Henk; ORCID: https://orcid.org/0000-0002-6629-318X
+Authors Full Name
+ Wang, Zheng; Groen, Henk; Cantineau, Astrid E P; van Elten, Tessa M; Karsten, Matty D A; van Oers, Anne M; Mol, Ben W J; Roseboom, Tessa J; Hoek, Annemieke.
+Institution
+ Wang, Zheng. Department of Obstetrics and Gynecology, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
+ Groen, Henk. Department of Epidemiology, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
+ Cantineau, Astrid E P. Department of Obstetrics and Gynecology, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
+ van Elten, Tessa M. Department of Public and Occupational Health, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1105 AZ Amsterdam, The Netherlands.
+ van Elten, Tessa M. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ van Elten, Tessa M. Department of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ van Elten, Tessa M. Amsterdam Public Health Research Institute, 1105 AZ Amsterdam, The Netherlands.
+ van Elten, Tessa M. Amsterdam Reproduction and Development, 1105 AZ Amsterdam, The Netherlands.
+ Karsten, Matty D A. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Karsten, Matty D A. Department of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Karsten, Matty D A. Amsterdam Public Health Research Institute, 1105 AZ Amsterdam, The Netherlands.
+ Karsten, Matty D A. Amsterdam Reproduction and Development, 1105 AZ Amsterdam, The Netherlands.
+ van Oers, Anne M. Department of Obstetrics and Gynecology, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
+ Mol, Ben W J. Department of Obstetrics and Gynecology, Monash University, Melbourne 3800, Australia.
+ Roseboom, Tessa J. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Roseboom, Tessa J. Department of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Roseboom, Tessa J. Amsterdam Public Health Research Institute, 1105 AZ Amsterdam, The Netherlands.
+ Roseboom, Tessa J. Amsterdam Reproduction and Development, 1105 AZ Amsterdam, The Netherlands.
+ Hoek, Annemieke. Department of Obstetrics and Gynecology, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
+MeSH Subject Headings
+ *Biomarkers
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ *Diet
+ Disease Susceptibility
+ *Exercise
+ Female
+ Health Impact Assessment
+ Humans
+ *Life Style
+ Netherlands/ep [Epidemiology]
+ *Obesity/ep [Epidemiology]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Polycystic Ovary Syndrome/ep [Epidemiology]
+ Polycystic Ovary Syndrome/et [Etiology]
+ Polycystic Ovary Syndrome/me [Metabolism]
+ Public Health Surveillance
+ *Quality of Life
+ Registries
+Keyword Heading
+ PCOS
+ cardiometabolic health
+ dietary intake
+ lifestyle intervention
+ obesity
+ physical activity
+ quality of life
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Little is known about the difference in effectiveness of lifestyle intervention between women with PCOS and non-PCOS women. In a post hoc longitudinal analysis of a randomized, controlled trial, we aimed to investigate whether infertile women with PCOS and obesity (N = 87) responded differently to a 6-month lifestyle intervention program than infertile non-PCOS obese controls (N = 172). We evaluated several aspects of the intervention such as changes in diet, physical activity, and dropout rate, as well as the effect on weight, quality of life (QoL), and cardiometabolic outcomes. Multilevel analyses were used, and analyses were adjusted for baseline characteristics such as age, education, and smoking. Although BMI in both groups significantly decreased at 3 months and 6 months, there were no significant differences between the groups at 3 months (adjusted B: -0.3, 95% CI: -0.9 to 0.3, p = 0.35) and 6 months (adjusted B: 0.5, 95% CI: -0.4 to 1.4, p = 0.29). Women with PCOS and non-PCOS women had similar compliance with the lifestyle intervention in terms of actual change in diet and physical activity. Mental QoL scores were not different at either 3 or 6 months. Physical QoL scores were lower in women with PCOS compared with non-PCOS women at 3 months (adjusted B: -2.4, 95% CI: -4.8 to -0.06, p = 0.045) but not at 6 months. Cardiometabolic parameters did not differ between the groups. Our results showed that infertile women with PCOS and obesity and non-PCOS obese controls responded largely similarly to our lifestyle intervention and achieved the same level of improvement in markers of cardiometabolic health.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13103425
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=2072-6643&title=Nutrients&atitle=Effectiveness+of+a+6-Month+Lifestyle+Intervention+on+Diet%2C+Physical+Activity%2C+Quality+of+Life%2C+and+Markers+of+Cardiometabolic+Health+in+Women+with+PCOS+and+Obesity+and+Non-PCOS+Obese+Controls%3A+One+Size+Fits+All%3F.&volume=13&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fnu13103425&pmid=34684438&sid=OVID:medline
+
+<720>
+Unique Identifier
+ 34684414
+Title
+ Antioxidants Supplementation Reduces Ceramide Synthesis Improving the Cardiac Insulin Transduction Pathway in a Rodent Model of Obesity.
+Source
+ Nutrients. 13(10), 2021 Sep 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hodun K; Sztolsztener K; Chabowski A
+Author NameID
+ Hodun, Katarzyna; ORCID: https://orcid.org/0000-0002-2102-7638
+ Sztolsztener, Klaudia; ORCID: https://orcid.org/0000-0003-1354-7585
+ Chabowski, Adrian; ORCID: https://orcid.org/0000-0002-7407-8156
+Authors Full Name
+ Hodun, Katarzyna; Sztolsztener, Klaudia; Chabowski, Adrian.
+Institution
+ Hodun, Katarzyna. Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland.
+ Sztolsztener, Klaudia. Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland.
+ Chabowski, Adrian. Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland.
+MeSH Subject Headings
+ Animal Feed
+ Animals
+ *Antioxidants/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Body Weight
+ *Ceramides/bi [Biosynthesis]
+ Diet, High-Fat
+ *Dietary Supplements
+ Glucose/me [Metabolism]
+ *Insulin/me [Metabolism]
+ Insulin Resistance
+ Male
+ Metabolic Networks and Pathways
+ Models, Animal
+ *Myocardium/me [Metabolism]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Phosphorylation
+ Rats
+ Rodentia
+ *Signal Transduction/de [Drug Effects]
+ Sphingolipids/me [Metabolism]
+Keyword Heading
+ cardiovascular diseases
+ ceramide
+ insulin resistance
+ left ventricle
+ n-acetylcysteine
+ sphingolipid
+ alpha-lipoic acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity-related disruption in lipid metabolism contributes to cardiovascular dysfunction. Despite numerous studies on lipid metabolism in the left ventricle, there is no data describing the influence of n-acetylcysteine (NAC) and alpha-lipoic acid (ALA), as glutathione precursors, on sphingolipid metabolism, and insulin resistance (IR) occurrence. The aim of our experiment was to evaluate the influence of chronic antioxidants administration on myocardial sphingolipid state and intracellular insulin signaling as a potential therapeutic strategy for obesity-related cardiovascular IR. The experiment was conducted on male Wistar rats fed a standard rodent chow or a high-fat diet with intragastric administration of NAC or ALA for eight weeks. Cardiac and plasma sphingolipid species were assessed by high-performance liquid chromatography (HPLC). The proteins expressed from sphingolipid and insulin signaling pathways were determined by Western blot. Antioxidant supplementation markedly reduced ceramide accumulation by lowering the expression of selected proteins from the sphingolipid pathway and simultaneously increased the myocardial sphingosine-1-phosphate level. Moreover, NAC and ALA augmented the expression of GLUT4 and the phosphorylation state of Akt (Ser473) and GSK3beta (Ser9), which improved the intracellular insulin transduction pathway. Based on our results, we may postulate that NAC and ALA have a beneficial influence on the cardiac ceramidose under IR conditions.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Ceramides). 0 (Insulin). 0 (Sphingolipids). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13103413
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hodun&issn=2072-6643&title=Nutrients&atitle=Antioxidants+Supplementation+Reduces+Ceramide+Synthesis+Improving+the+Cardiac+Insulin+Transduction+Pathway+in+a+Rodent+Model+of+Obesity.&volume=13&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fnu13103413&pmid=34684414&sid=OVID:medline
+
+<721>
+Unique Identifier
+ 34684358
+Title
+ Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues.
+Source
+ Nutrients. 13(10), 2021 Sep 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Da Eira D; Jani S; Ceddia RB
+Authors Full Name
+ Da Eira, Daniel; Jani, Shailee; Ceddia, Rolando B.
+Institution
+ Da Eira, Daniel. Muscle Health Research Center, School of Kinesiology and Health Science, York University, Toronto, ON M3J1P3, Canada.
+ Jani, Shailee. Muscle Health Research Center, School of Kinesiology and Health Science, York University, Toronto, ON M3J1P3, Canada.
+ Ceddia, Rolando B. Muscle Health Research Center, School of Kinesiology and Health Science, York University, Toronto, ON M3J1P3, Canada.
+MeSH Subject Headings
+ Angiotensin-Converting Enzyme 2/ge [Genetics]
+ *Angiotensin-Converting Enzyme 2/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ COVID-19/co [Complications]
+ COVID-19/me [Metabolism]
+ *COVID-19/pa [Pathology]
+ *Diet, High-Fat/ae [Adverse Effects]
+ *Diet, Ketogenic/mt [Methods]
+ Disease Models, Animal
+ *Lung/me [Metabolism]
+ Male
+ *Myocardium/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Rats
+ Rats, Sprague-Dawley
+ Renin-Angiotensin System
+ SARS-CoV-2
+ Serine Endopeptidases/ge [Genetics]
+ *Serine Endopeptidases/me [Metabolism]
+ Virus Internalization
+Keyword Heading
+ IL6
+ MasR
+ TLR4
+ TNF-alpha
+ inflammation
+ ketones
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity increases the severity of SARS-CoV-2 outcomes. Thus, this study tested whether obesogenic and ketogenic diets distinctly affect SARS-CoV-2 entry proteins and the renin-angiotensin system (RAS) in rat pulmonary and cardiac tissues.
+
+ METHODS: Male Sprague-Dawley rats were fed either standard chow (SC), a high-fat sucrose-enriched diet (HFS), or a ketogenic diet (KD) for 16 weeks. Afterwards, levels of angiotensin converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), RAS components, and inflammatory genes were measured in the lungs and hearts of these animals.
+
+ RESULTS: In the lungs, HFS elevated ACE2 and TMPRSS2 levels relative to SC diet, whereas the KD lowered the levels of these proteins and the gene expressions of toll-like receptor 4 and interleukin-6 receptor relative to HFS. The diets did not alter ACE2 and TMPRSS2 in the heart, although ACE2 was more abundant in heart than lung tissues.
+
+ CONCLUSION: Diet-induced obesity increased the levels of viral entry proteins in the lungs, providing a mechanism whereby SARS-CoV-2 infectivity can be enhanced in obese individuals. Conversely, by maintaining low levels of ACE2 and TMPRSS2 and by exerting an anti-inflammatory effect, the KD can potentially attenuate the severity of infection and migration of SARS-CoV-2 to other ACE2-expressing tissues.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4-17-23 (Ace2 protein, rat). EC 3-4-17-23 (Angiotensin-Converting Enzyme 2). EC 3-4-21 (Serine Endopeptidases). EC 3-4-21 (Tmprss2 protein, rat).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13103357
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Da+Eira&issn=2072-6643&title=Nutrients&atitle=Obesogenic+and+Ketogenic+Diets+Distinctly+Regulate+the+SARS-CoV-2+Entry+Proteins+ACE2+and+TMPRSS2+and+the+Renin-Angiotensin+System+in+Rat+Lung+and+Heart+Tissues.&volume=13&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fnu13103357&pmid=34684358&sid=OVID:medline
+
+<722>
+Unique Identifier
+ 34680168
+Title
+ Changes of Metabolic Biomarker Levels upon One-Year Anti-TNF-alpha Therapy in Rheumatoid Arthritis and Ankylosing Spondylitis: Associations with Vascular Pathophysiology.
+Source
+ Biomolecules. 11(10), 2021 10 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Czokolyova M; Pusztai A; Vegh E; Horvath A; Szentpeteri A; Hamar A; Szamosi S; Hodosi K; Domjan A; Szanto S; Kerekes G; Seres I; Harangi M; Paragh G; Szekanecz E; Szekanecz Z; Szucs G
+Author NameID
+ Harangi, Mariann; ORCID: https://orcid.org/0000-0001-9761-9595
+Authors Full Name
+ Czokolyova, Monika; Pusztai, Anita; Vegh, Edit; Horvath, Agnes; Szentpeteri, Anita; Hamar, Attila; Szamosi, Szilvia; Hodosi, Katalin; Domjan, Andrea; Szanto, Sandor; Kerekes, Gyorgy; Seres, Ildiko; Harangi, Mariann; Paragh, Gyorgy; Szekanecz, Eva; Szekanecz, Zoltan; Szucs, Gabriella.
+Institution
+ Czokolyova, Monika. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Pusztai, Anita. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Vegh, Edit. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Horvath, Agnes. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Szentpeteri, Anita. Division of Metabolic Diseases, Department of Medicine, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Hamar, Attila. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Szamosi, Szilvia. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Hodosi, Katalin. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Domjan, Andrea. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Szanto, Sandor. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Szanto, Sandor. Department of Sports Medicine, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Kerekes, Gyorgy. Intensive Care Unit, Department of Medicine, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Seres, Ildiko. Division of Metabolic Diseases, Department of Medicine, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Harangi, Mariann. Division of Metabolic Diseases, Department of Medicine, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Paragh, Gyorgy. Division of Metabolic Diseases, Department of Medicine, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Szekanecz, Eva. Department of Oncology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Szekanecz, Zoltan. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+ Szucs, Gabriella. Division of Rheumatology, Faculty of Medicine, University of Debrecen, 4031 Debrecen, Hungary.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Arthritis, Rheumatoid/bl [Blood]
+ Arthritis, Rheumatoid/co [Complications]
+ *Arthritis, Rheumatoid/dt [Drug Therapy]
+ Arthritis, Rheumatoid/me [Metabolism]
+ Aryldialkylphosphatase/bl [Blood]
+ Biomarkers/bl [Blood]
+ *C-Reactive Protein/me [Metabolism]
+ Carboxylic Ester Hydrolases/bl [Blood]
+ Carotid Intima-Media Thickness
+ Certolizumab Pegol/ad [Administration & Dosage]
+ Etanercept/ad [Administration & Dosage]
+ Female
+ Heart Disease Risk Factors
+ Humans
+ Lipid Metabolism/de [Drug Effects]
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/dt [Drug Therapy]
+ Peroxidase/bl [Blood]
+ Spondylitis, Ankylosing/bl [Blood]
+ Spondylitis, Ankylosing/co [Complications]
+ *Spondylitis, Ankylosing/dt [Drug Therapy]
+ Tumor Necrosis Factor-alpha/ai [Antagonists & Inhibitors]
+ *Tumor Necrosis Factor-alpha/ge [Genetics]
+Keyword Heading
+ adipokines
+ ankylosing spondylitis
+ biologic therapy
+ lipids
+ metabolic biomarkers
+ rheumatoid arthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Cardiovascular (CV) morbidity, mortality, and metabolic syndrome are associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Here, lipids and other metabolic markers in relation to vascular function and clinical markers were evaluated in RA and AS patients undergoing one-year anti-TNF therapy.
+
+ PATIENTS AND METHODS: Fifty-three patients including 36 RA patients treated with either etanercept (ETN) or certolizumab pegol (CZP) and 17 AS patients treated with ETN were included in a 12-month follow-up study. Various lipids, paraoxonase (PON) and arylesterase (ARE) activities, myeloperoxidase (MPO) and adipokine levels were determined overtime. Ultrasonography was performed to determine flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT), and arterial pulse-wave velocity (PWV) in all patients. All assessments were performed at baseline and 6 and 12 months after treatment initiation.
+
+ RESULTS: Anti-TNF therapy decreased ARE activity, MPO, adiponectin, and chemerin levels after 12 months (p < 0.05). Lipids, PON activity, and leptin remained unchanged. Regression analyses suggested variable associations of IMT, PWV, and FMD with ARE, MPO, leptin, and lipids (p < 0.05). On the other hand, these metabolic parameters were significantly associated with disease duration, CV history, CRP, obesity, PWV, and IMT (p < 0.05). One-year anti-TNF treatment together with baseline leptin (p = 0.039) or CRP (p = 0.016) levels determined 12 months of lipid changes overtime. TNF inhibition together with baseline disease activity determined ARE activity changes (p = 0.046). Anti-TNF therapy and baseline chemerin levels determined IMT changes overtime (p = 0.003).
+
+ CONCLUSIONS: Assessment of various metabolic parameters together with disease activity, CRP, and ultrasound-based techniques may exert additional value in determining CV burden and in monitoring the effects of biologics on preclinical vascular pathophysiology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 0 (Tumor Necrosis Factor-alpha). 9007-41-4 (C-Reactive Protein). EC 1-11-1-7 (Peroxidase). EC 3-1-1 (Carboxylic Ester Hydrolases). EC 3-1-1-2 (arylesterase). EC 3-1-8-1 (Aryldialkylphosphatase). OP401G7OJC (Etanercept). UMD07X179E (Certolizumab Pegol).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fbiom11101535
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Czokolyova&issn=2218-273X&title=Biomolecules&atitle=Changes+of+Metabolic+Biomarker+Levels+upon+One-Year+Anti-TNF-alpha+Therapy+in+Rheumatoid+Arthritis+and+Ankylosing+Spondylitis%3A+Associations+with+Vascular+Pathophysiology.&volume=11&issue=10&spage=&epage=&date=2021&doi=10.3390%2Fbiom11101535&pmid=34680168&sid=OVID:medline
+
+<723>
+Unique Identifier
+ 34641550
+Title
+ Overexpression of the Gene Encoding Neurosecretory Protein GL Precursor Prevents Excessive Fat Accumulation in the Adipose Tissue of Mice Fed a Long-Term High-Fat Diet.
+Source
+ Molecules. 26(19), 2021 Oct 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fukumura K; Narimatsu Y; Moriwaki S; Iwakoshi-Ukena E; Furumitsu M; Ukena K
+Author NameID
+ Ukena, Kazuyoshi; ORCID: https://orcid.org/0000-0003-0942-6035
+Authors Full Name
+ Fukumura, Keisuke; Narimatsu, Yuki; Moriwaki, Shogo; Iwakoshi-Ukena, Eiko; Furumitsu, Megumi; Ukena, Kazuyoshi.
+Institution
+ Fukumura, Keisuke. Laboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
+ Narimatsu, Yuki. Laboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
+ Moriwaki, Shogo. Laboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
+ Iwakoshi-Ukena, Eiko. Laboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
+ Furumitsu, Megumi. Laboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
+ Ukena, Kazuyoshi. Laboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ Body Weight
+ Diet, High-Fat
+ Energy Metabolism/ge [Genetics]
+ Feeding Behavior
+ Glucose Tolerance Test
+ Insulin/bl [Blood]
+ Lipid Metabolism/ge [Genetics]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Nerve Tissue Proteins/ge [Genetics]
+ *Nerve Tissue Proteins/ph [Physiology]
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+Keyword Heading
+ glucose tolerance
+ hypothalamus
+ insulin sensitivity
+ neuropeptide
+ neurosecretory protein GL
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We previously identified a novel small hypothalamic protein, neurosecretory protein GL (NPGL), which induces feeding behavior and fat accumulation in rodents depending on their diet. In the present study, we explored the effects of NPGL on feeding behavior and energy metabolism in mice placed on a long-term high-fat diet with 60% calories from fat (HFD 60). Overexpression of the NPGL precursor gene (Npgl) over 18 weeks increased food intake and weight. The weekly weight gain of Npgl-overexpressing mice was higher than that of controls until 7 weeks from induction of overexpression, after which it ceased to be so. Oral glucose tolerance tests showed that Npgl overexpression maintained glucose tolerance and increased blood insulin levels, and intraperitoneal insulin tolerance tests showed that it maintained insulin sensitivity. At the experimental endpoint, Npgl overexpression was associated with increased mass of the perirenal white adipose tissue (WAT) and decreased mass of the epididymal WAT (eWAT), resulting in little effect on the total WAT mass. These results suggest that under long-term HFD 60 feeding, Npgl overexpression may play a role in avoiding metabolic disturbance both by accelerating energy storage and by suppressing excess fat accumulation in certain tissues, such as the eWAT.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 0 (Nerve Tissue Proteins). 0 (RNA, Messenger). 0 (neurosecretory protein GL, mouse).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fmolecules26196006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fukumura&issn=1420-3049&title=Molecules&atitle=Overexpression+of+the+Gene+Encoding+Neurosecretory+Protein+GL+Precursor+Prevents+Excessive+Fat+Accumulation+in+the+Adipose+Tissue+of+Mice+Fed+a+Long-Term+High-Fat+Diet.&volume=26&issue=19&spage=6006&epage=&date=2021&doi=10.3390%2Fmolecules26196006&pmid=34641550&sid=OVID:medline
+
+<724>
+Unique Identifier
+ 34638758
+Title
+ Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study.
+Source
+ International Journal of Molecular Sciences. 22(19), 2021 Sep 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gutierrez-Repiso C; Linares-Pineda TM; Gonzalez-Jimenez A; Aguilar-Lineros F; Valdes S; Soriguer F; Rojo-Martinez G; Tinahones FJ; Morcillo S
+Author NameID
+ Gutierrez-Repiso, Carolina; ORCID: https://orcid.org/0000-0002-5842-8873
+ Valdes, Sergio; ORCID: https://orcid.org/0000-0001-8623-4331
+ Rojo-Martinez, Gemma; ORCID: https://orcid.org/0000-0003-2179-2134
+ Morcillo, Sonsoles; ORCID: https://orcid.org/0000-0001-6932-5637
+Authors Full Name
+ Gutierrez-Repiso, Carolina; Linares-Pineda, Teresa Maria; Gonzalez-Jimenez, Andres; Aguilar-Lineros, Francisca; Valdes, Sergio; Soriguer, Federico; Rojo-Martinez, Gemma; Tinahones, Francisco J; Morcillo, Sonsoles.
+Institution
+ Gutierrez-Repiso, Carolina. Unidad de Gestion Clinica de Endocrinologia y Nutricion del Hospital Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Gutierrez-Repiso, Carolina. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Linares-Pineda, Teresa Maria. Unidad de Gestion Clinica de Endocrinologia y Nutricion del Hospital Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Gonzalez-Jimenez, Andres. ECAI Bioinformatica Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Aguilar-Lineros, Francisca. Unidad de Gestion Clinica de Endocrinologia y Nutricion del Hospital Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Valdes, Sergio. Departamento de Endocrinologia and Nutricion, Hospital Regional Universitario de Malaga, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29009 Malaga, Spain.
+ Valdes, Sergio. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Soriguer, Federico. Departamento de Endocrinologia and Nutricion, Hospital Regional Universitario de Malaga, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29009 Malaga, Spain.
+ Soriguer, Federico. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Rojo-Martinez, Gemma. Departamento de Endocrinologia and Nutricion, Hospital Regional Universitario de Malaga, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29009 Malaga, Spain.
+ Rojo-Martinez, Gemma. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Tinahones, Francisco J. Unidad de Gestion Clinica de Endocrinologia y Nutricion del Hospital Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Tinahones, Francisco J. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Tinahones, Francisco J. Departamento de Medicina y Dermatologia, Universidad de Malaga, 29010 Malaga, Spain.
+ Morcillo, Sonsoles. Unidad de Gestion Clinica de Endocrinologia y Nutricion del Hospital Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Morcillo, Sonsoles. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/me [Metabolism]
+ *CpG Islands
+ *DNA Methylation
+ *Epigenesis, Genetic
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ Phenotype
+ Prospective Studies
+Keyword Heading
+ DNA methylation
+ epigenetic biomarkers
+ metabolic syndrome
+ metabolically healthy obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Identifying those parameters that could potentially predict the deterioration of metabolically healthy phenotype is a matter of debate. In this field, epigenetics, in particular DNA methylation deserves special attention.
+
+ RESULTS: The aim of the present study was to analyze the long-term evolution of methylation patterns in a subset of metabolically healthy subjects in order to search for epigenetic markers that could predict the progression to an unhealthy state. Twenty-six CpG sites were significantly differentially methylated, both at baseline and 11-year follow-up. These sites were related to 19 genes or pseudogenes; a more in-depth analysis of the methylation sites of these genes showed that CYP2E1 had 50% of the collected CpG sites differently methylated between stable metabolically healthy obesity (MHO) and unstable MHO, followed by HLA-DRB1 (33%), ZBTB45 (16%), HOOK3 (14%), PLCZ1 (14%), SLC1A1 (12%), MUC2 (12%), ZFPM2 (12.5%) and HLA-DQB2 (8%). Pathway analysis of the selected 26 CpG sites showed enrichment in pathways linked to th1 and th2 activation, antigen presentation, allograft rejection signals and metabolic processes. Higher methylation levels in the cg20707527 (ZFPM2) could have a protective effect against the progression to unstable MHO (OR: 0.21, 95%CI (0.067-0.667), p < 0.0001), whilst higher methylation levels in cg11445109 (CYP2E1) would increase the progression to MUO; OR: 2.72, 95%CI (1.094-6.796), p < 0.0014; respectively).
+
+ CONCLUSIONS: DNA methylation status is associated with the stability/worsening of MHO phenotype. Two potential biomarkers of the transition to an unhealthy state were identified and deserve further investigation (cg20707527 and cg11445109). Moreover, the described differences in methylation could alter immune system-related pathways, highlighting these pathways as therapeutic targets to prevent metabolic deterioration in MHO patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms221910417
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gutierrez-Repiso&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Epigenetic+Biomarkers+of+Transition+from+Metabolically+Healthy+Obesity+to+Metabolically+Unhealthy+Obesity+Phenotype%3A+A+Prospective+Study.&volume=22&issue=19&spage=10417&epage=&date=2021&doi=10.3390%2Fijms221910417&pmid=34638758&sid=OVID:medline
+
+<725>
+Unique Identifier
+ 34633422
+Title
+ Whole-fat dairy products do not adversely affect adiposity or cardiometabolic risk factors in children in the Milky Way Study: a double-blind randomized controlled pilot study.
+Source
+ American Journal of Clinical Nutrition. 114(6):2025-2042, 2021 12 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nicholl A; Deering KE; Evelegh K; Lyons-Wall P; Lawrence D; Mori TA; Kratz M; O'Sullivan TA
+Author NameID
+ Nicholl, Analise; ORCID: https://orcid.org/0000-0003-4970-8096
+ Evelegh, Kate; ORCID: https://orcid.org/0000-0003-3455-6886
+ Lyons-Wall, Philippa; ORCID: https://orcid.org/0000-0002-0001-1055
+ Lawrence, David; ORCID: https://orcid.org/0000-0003-4700-1425
+ Mori, Trevor A; ORCID: https://orcid.org/0000-0002-5264-9229
+ O'Sullivan, Therese A; ORCID: https://orcid.org/0000-0003-1003-854X
+Authors Full Name
+ Nicholl, Analise; Deering, Kane E; Evelegh, Kate; Lyons-Wall, Philippa; Lawrence, David; Mori, Trevor A; Kratz, Mario; O'Sullivan, Therese A.
+Institution
+ Nicholl, Analise. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
+ Deering, Kane E. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
+ Evelegh, Kate. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
+ Lyons-Wall, Philippa. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
+ Lawrence, David. Graduate School of Education, Faculty of Arts, Business, Law and Education, University of Western Australia, Perth, Western Australia, Australia.
+ Mori, Trevor A. Medical School, University of Western Australia, Perth, Western Australia, Australia.
+ Kratz, Mario. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
+ Kratz, Mario. Department of Epidemiology, University of Washington, Seattle, WA, USA.
+ O'Sullivan, Therese A. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
+MeSH Subject Headings
+ *Adiposity
+ Biomarkers
+ *Cardiometabolic Risk Factors
+ Child
+ Child, Preschool
+ Dairy Products/ae [Adverse Effects]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Lipids
+ Male
+ Obesity
+ Pilot Projects
+Keyword Heading
+ BodPod
+ Milky Way Study
+ air displacement plethysmography
+ cardiometabolic disease
+ child-centered care
+ cholesterol
+ dairy fat
+ dietary fat
+ pediatric
+ randomized controlled trial
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Limited evidence supports the common public health guideline that children >2 y of age should consume dairy with reduced fat content.
+
+ OBJECTIVES: We aimed to investigate the effects of whole-fat compared with reduced-fat dairy intake on measures of adiposity and biomarkers of cardiometabolic risk in healthy 4- to 6-y-old children.
+
+ METHODS: The Milky Way Study enrolled 49 children (mean +/- SD age: 5.2 +/- 0.9 y; 47% girls) who were habitual consumers of whole-fat dairy, then randomly assigned them in a double-blind fashion to remain on whole-fat dairy or switch their dairy consumption to reduced-fat products for 3 mo. Primary endpoints included measures of adiposity, body composition, blood pressure, fasting serum lipids, blood glucose, glycated hemoglobin (HbA1c), and C-reactive protein (CRP) and were assessed at baseline and study end. Pre- and postintervention results were compared using linear mixed models, adjusted for growth, age, and sex.
+
+ RESULTS: Dairy fat intake was reduced by an adjusted (mean +/- SEM) 12.9 +/- 4.1 g/d in the reduced-fat compared with the whole-fat dairy group (95% CI: -21.2, -4.6 g/d; P = 0.003), whereas dietary energy intakes remained similar (P = 0.936). We found no significant differential changes between dairy groups in any measure of adiposity, body composition, blood pressure, or fasting serum lipids, glucose, HbA1c, and CRP.
+
+ CONCLUSIONS: Our results suggest that although changing from whole-fat to reduced-fat dairy products does reduce dairy fat intake, it does not result in changes to markers of adiposity or cardiometabolic disease risk in healthy children. This trial was registered at www.anzctr.org.au as ACTRN12616001642471. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Lipids).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1093%2fajcn%2fnqab288
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nicholl&issn=0002-9165&title=American+Journal+of+Clinical+Nutrition&atitle=Whole-fat+dairy+products+do+not+adversely+affect+adiposity+or+cardiometabolic+risk+factors+in+children+in+the+Milky+Way+Study%3A+a+double-blind+randomized+controlled+pilot+study.&volume=114&issue=6&spage=2025&epage=2042&date=2021&doi=10.1093%2Fajcn%2Fnqab288&pmid=34633422&sid=OVID:medline
+
+<726>
+Unique Identifier
+ 34630316
+Title
+ Serum Metabolic Profiles of Chinese Women With Perimenopausal Obesity Explored by the Untargeted Metabolomics Approach.
+Source
+ Frontiers in Endocrinology. 12:637317, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ding S; Chen M; Liao Y; Chen Q; Lin X; Chen S; Chai Y; Li C; Asakawa T
+Authors Full Name
+ Ding, Shanshan; Chen, Mingyi; Liao, Ying; Chen, Qiliang; Lin, Xuejuan; Chen, Shujiao; Chai, Yujuan; Li, Candong; Asakawa, Tetsuya.
+Institution
+ Ding, Shanshan. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
+ Chen, Mingyi. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
+ Liao, Ying. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
+ Chen, Qiliang. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
+ Chen, Qiliang. School of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
+ Lin, Xuejuan. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
+ Chen, Shujiao. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
+ Chai, Yujuan. School of Medical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
+ Li, Candong. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
+ Asakawa, Tetsuya. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
+ Asakawa, Tetsuya. Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
+ Asakawa, Tetsuya. Department of Neurology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ China/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Metabolome
+ *Metabolomics/mt [Methods]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ *Perimenopause
+ Prognosis
+Keyword Heading
+ metabolic pathway
+ metabolic profiles
+ metabolomics
+ perimenopausal obesity
+ the ultra-high performance liquid chromatography-quadrupole time-of-flight/mass spectrometry
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ By far, no study has focused on observing the metabolomic profiles in perimenopause-related obesity. This study attempted to identify the metabolic characteristics of subjects with perimenopause obesity (PO). Thirty-nine perimenopausal Chinese women, 21 with PO and 18 without obesity (PN), were recruited in this study. A conventional ultra-high-performance liquid chromatography-quadrupole time-of-flight/mass spectrometry (UHPLC-QTOF/MS) followed by principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) were used as untargeted metabolomics approaches to explore the serum metabolic profiles. Kyoto Encyclopedia of Genes and Genomes (KEGG) and MetaboAnalyst were used to identify the related metabolic pathways. A total of 46 differential metabolites, along with seven metabolic pathways relevant to PO were identified, which belonged to lipid, amino acids, carbohydrates, and organic acids. As for amino acids, we found a significant increase in l-arginine and d-ornithine in the positive ion (POS) mode and l-leucine, l-valine, l-tyrosine, and N-acetyl-l-tyrosine in the negative ion (NEG) mode and a significant decrease in l-proline in the POS mode of the PO group. We also found phosphatidylcholine (PC) (16:0/16:0), palmitic acid, and myristic acid, which are associated with the significant upregulation of lipid metabolism. Moreover, the serum indole lactic acid and indoleacetic acid were upregulated in the NEG mode. With respect to the metabolic pathways, the d-arginine and d-ornithine metabolisms and the arginine and proline metabolism pathways in POS mode were the most dominant PO-related pathways. The changes of metabolisms of lipid, amino acids, and indoleacetic acid provided a pathophysiological scenario for Chinese women with PO. We believe that the findings of this study are helpful for clinicians to take measures to prevent the women with PO from developing severe incurable obesity-related complications, such as cardiovascular disease and stroke. Copyright © 2021 Ding, Chen, Liao, Chen, Lin, Chen, Chai, Li and Asakawa.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.637317
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ding&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Serum+Metabolic+Profiles+of+Chinese+Women+With+Perimenopausal+Obesity+Explored+by+the+Untargeted+Metabolomics+Approach.&volume=12&issue=&spage=637317&epage=&date=2021&doi=10.3389%2Ffendo.2021.637317&pmid=34630316&sid=OVID:medline
+
+<727>
+Unique Identifier
+ 34629064
+Title
+ Lipid biomarkers and Cancer risk - a population-based prospective cohort study in Taiwan.
+Source
+ Lipids in Health & Disease. 20(1):133, 2021 Oct 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chang YC; Lin CJ; Yeh TL; Tsai MC; Hsu LY; Chien KL; Hsu HY
+Author NameID
+ Hsu, Hsin-Yin; ORCID: http://orcid.org/0000-0003-1734-0012
+Authors Full Name
+ Chang, Yu-Chen; Lin, Chien-Ju; Yeh, Tzu-Lin; Tsai, Ming-Chieh; Hsu, Le-Yin; Chien, Kuo-Liong; Hsu, Hsin-Yin.
+Institution
+ Chang, Yu-Chen. Department of Family Medicine, MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City, 10449, Taiwan.
+ Chang, Yu-Chen. The Department of Medicine, MacKay Medical College, No. 46, Sec. 3, Zhongzheng Rd, New Taipei City, 25245, Taiwan.
+ Lin, Chien-Ju. Department of Family Medicine, Hsinchu MacKay Memorial Hospital, No. 690, Section 2, Guangfu Road, East District, Hsinchu City, 30071, Taiwan.
+ Yeh, Tzu-Lin. Department of Family Medicine, Hsinchu MacKay Memorial Hospital, No. 690, Section 2, Guangfu Road, East District, Hsinchu City, 30071, Taiwan.
+ Yeh, Tzu-Lin. Institute of Epidemiology and Preventive Medicine, National Taiwan University, Room 517, No. 17, Xu-Zhou Rd, Taipei City, Taiwan, 10055.
+ Tsai, Ming-Chieh. Department of Endocrinology, Department of Internal Medicine, Mackay Memorial Hospital, Tamsui Branch, 25160, New Taipei City, Taiwan.
+ Hsu, Le-Yin. Institute of Epidemiology and Preventive Medicine, National Taiwan University, Room 517, No. 17, Xu-Zhou Rd, Taipei City, Taiwan, 10055.
+ Chien, Kuo-Liong. Institute of Epidemiology and Preventive Medicine, National Taiwan University, Room 517, No. 17, Xu-Zhou Rd, Taipei City, Taiwan, 10055.
+ Chien, Kuo-Liong. Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S. Rd., Zhongzheng Dist, Taipei City, Taiwan, 10002.
+ Hsu, Hsin-Yin. Department of Family Medicine, MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City, 10449, Taiwan. camelhsu@gmail.com.
+ Hsu, Hsin-Yin. The Department of Medicine, MacKay Medical College, No. 46, Sec. 3, Zhongzheng Rd, New Taipei City, 25245, Taiwan. camelhsu@gmail.com.
+MeSH Subject Headings
+ Adult
+ Asian People
+ Biomarkers/bl [Blood]
+ *Cholesterol, HDL/bl [Blood]
+ *Cholesterol, LDL/bl [Blood]
+ Female
+ Humans
+ Incidence
+ Male
+ Middle Aged
+ *Neoplasms/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease
+ Obesity/bl [Blood]
+ Prospective Studies
+ Risk Factors
+ Taiwan/ep [Epidemiology]
+Keyword Heading
+ Blood lipids
+ Cohort study
+ Interval change
+ Low-density lipoprotein cholesterol
+ Non-high-density lipoprotein cholesterol
+ Total cholesterol
+ cancer risk
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Blood lipids are essential components for cellular growth. An inverse association between serum lipid levels and risk of cancer has led to a controversy among previous studies. The aim of this prospective cohort study was to investigate the association between blood lipids change and risk of cancer incidence.
+
+ METHODS: A cohort of 4130 Taiwanese adults from the Taiwanese Survey on the Prevalence of Hypertension, Hyperglycemia, and Hyperlipidemia database underwent repeated examinations in 2002 and 2007. Six groups were established based on the combined baseline (lower/higher) and interval change (decreasing/stable/increasing) in plasma lipid levels. Multivariable Cox proportional hazard model was used to investigate the relationship between lipids change and all-cause cancer incidence.
+
+ RESULTS: Two hundred and forty cancer events developed over a median follow-up of 13.4 years. Comparing these with individuals with decreasing lower-baseline lipid levels, cancer risk reduction was demonstrated in those with increasing lower-baseline total cholesterol (adjusted hazard ratio [aHR], 0.48; 95% confidence interval [CI], 0.27 to 0.85), low-density lipoprotein cholesterol (LDL-C; aHR, 0.56; 95% CI, 0.35 to 0.92), and non-high-density lipoprotein cholesterol (non-HDL-C) (aHR, 0.54; 95% CI, 0.31 to 0.92) levels. A decreased risk for cancer incidence also presented in participants with stable lower-baseline, decreasing and increasing higher-baseline LDL-C levels, and with decreasing and stable higher-baseline non-HDL-C levels.
+
+ CONCLUSIONS: The interval decline in lower-baseline total cholesterol, LDL-C, and non-HDL-C levels was linked to a higher risk for all-cause cancer incidence. More attention to a potential cancer risk may be warranted for an unexplained fall in serum lipids. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12944-021-01570-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chang&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Lipid+biomarkers+and+Cancer+risk+-+a+population-based+prospective+cohort+study+in+Taiwan.&volume=20&issue=1&spage=133&epage=&date=2021&doi=10.1186%2Fs12944-021-01570-1&pmid=34629064&sid=OVID:medline
+
+<728>
+Unique Identifier
+ 34625598
+Title
+ Effects of exenatide on urinary albumin in overweight/obese patients with T2DM: a randomized clinical trial.
+Source
+ Scientific Reports. 11(1):20062, 2021 10 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kang C; Qiao Q; Tong Q; Bai Q; Huang C; Fan R; Wang H; Kaliannan K; Wang J; Xu J
+Authors Full Name
+ Kang, Chao; Qiao, Qiao; Tong, Qiang; Bai, Qian; Huang, Chen; Fan, Rong; Wang, Hui; Kaliannan, Kanakaraju; Wang, Jian; Xu, Jing.
+Institution
+ Kang, Chao. Department of Nutriology of The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
+ Qiao, Qiao. Department of Endocrinology of Xinqiao Hospital, Army Medical University, Chongqing, China.
+ Tong, Qiang. Department of Endocrinology of Xinqiao Hospital, Army Medical University, Chongqing, China.
+ Bai, Qian. Department of Nutriology of Xinqiao Hospital, Army Medical University, Chongqing, China.
+ Huang, Chen. Department of Nutriology of Xinqiao Hospital, Army Medical University, Chongqing, China.
+ Fan, Rong. Department of Nutriology of Xinqiao Hospital, Army Medical University, Chongqing, China.
+ Wang, Hui. Department of Nutriology of Xinqiao Hospital, Army Medical University, Chongqing, China.
+ Kaliannan, Kanakaraju. Laboratory of Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
+ Wang, Jian. Department of Nutriology of Xinqiao Hospital, Army Medical University, Chongqing, China. wangjianxq@hotmail.com.
+ Xu, Jing. Department of Endocrinology of Xinqiao Hospital, Army Medical University, Chongqing, China. 13512380018@163.com.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ *Exenatide/tu [Therapeutic Use]
+ Female
+ Fibroblast Growth Factors/me [Metabolism]
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+Abstract
+ In this study, we investigated the effect of exenatide (EXE), a glucagon-like peptide (GLP)-1 receptor agonist, on kidney function, obesity indices, and glucose control in overweight/obese patients with type 2 diabetes mellitus (T2DM). A total of 159 overweight/obese patients with T2DM were randomized to the EXE group or insulin glargine (GLAR) control group for a total treatment period of 24 weeks. EXE intervention significantly reduced the urine albumin concentration (UAC) at week 12 and 24 endpoints (P < 0.001 at week 12 and 24). The levels of the anthropometric, glucose and lipid parameters (TG and HDL-c), and inflammation biomarkers (CRP and TNF-alpha) in the EXE group were improved at 12 weeks or 24 weeks, respectively. Meanwhile, a comparison between two groups showed significant changes in anthropometric parameters, glucose parameters, lipid parameters (TG and HDL-c), and Inflammation biomarkers (CRP, IL-6, and TNF-alpha). Serum fibroblast growth factor 21 (FGF21) was increased in the EXE group (P = 0.005) at week 24, and the change was significantly improved compared with GLAR group (P = 0.003). Correlation network analysis showed that FGF21 had a more central role in improving metabolism in the EXE group, and the change of FGF 21 was significantly negatively correlated with UAC at week 12 and week 24, respectively (r = - 0.297, P = 0.010; r = - 0.294, P = 0.012). Our results showed that EXE could help patients improve UAC, glycemic levels, and inflammatory biomarkers after a follow-up period of 24 weeks intervention. These EXE effects may be partly mediated by FGF 21, indicating that EXE is an effective and safe way to control albuminuria in overweight/obese patients with T2DM. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (fibroblast growth factor 21). 0 (hemoglobin A1c protein, human). 62031-54-3 (Fibroblast Growth Factors). 9P1872D4OL (Exenatide).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-99527-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kang&issn=2045-2322&title=Scientific+Reports&atitle=Effects+of+exenatide+on+urinary+albumin+in+overweight%2Fobese+patients+with+T2DM%3A+a+randomized+clinical+trial.&volume=11&issue=1&spage=20062&epage=&date=2021&doi=10.1038%2Fs41598-021-99527-y&pmid=34625598&sid=OVID:medline
+
+<729>
+Unique Identifier
+ 34620331
+Title
+ Vitamin D status and systemic redox biomarkers in adults with obesity.
+Source
+ Clinical Nutrition ESPEN. 45:292-298, 2021 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Asghari S; Hamedi-Shahraki S; Amirkhizi F
+Authors Full Name
+ Asghari, Somayyeh; Hamedi-Shahraki, Soudabeh; Amirkhizi, Farshad.
+Institution
+ Asghari, Somayyeh. Department of Clinical Nutrition, Faculty of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Hamedi-Shahraki, Soudabeh. Department of Epidemiology and Biostatistics, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran.
+ Amirkhizi, Farshad. Department of Nutrition, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran. Electronic address: amirkhizi.f@gmail.com.
+MeSH Subject Headings
+ Aryldialkylphosphatase
+ Biomarkers
+ Case-Control Studies
+ Humans
+ *Obesity
+ Oxidation-Reduction
+ *Vitamin D
+Keyword Heading
+ Antioxidant enzymes
+ Obesity
+ Oxidative stress
+ Redox
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: Vitamin D has been proposed to have a protective role against oxidative stress. The present study was conducted to test the hypothesis that suboptimal levels of 25(OH)D are related to oxidative/antioxidative biomarkers in adults independently of obesity.
+
+ METHODS: In this case-control study, 140 subjects with obesity and 90 age- and sex-matched 25(OH)D sufficient normal weight controls were selected. Subjects with obesity were categorized as 25(OH)D sufficient, insufficient, and deficient based on their serum 25(OH)D concentrations. Serum malondialdehyde (MDA), total oxidant status (TOS), and total antioxidant capacity (TAC) as well as erythrocytes superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) along with serum paraoxonase-1 (PON1) and arylesterase (AREase) activities were assessed.
+
+ RESULTS: Serum concentrations of 25(OH)D were inversely correlated with BMI, WC, fat mass, and visceral fat. Serum levels of MDA and TOS, and erythrocyte SOD activities were significantly higher, whereas, serum TAC, PON1, and AREase were significantly lower in subjects with obesity compared to the controls (p < 0.0001). 25(OH)D deficient obese subjects exhibited higher serum levels of MDA as well as erythrocyte SOD activity (p < 0.05) and lower serum levels of TAC (p < 0.0001), PON1 (p < 0.05), and AREase (p < 0.0001) compared to obese subjects with 25(OH)D sufficiency and controls even when adjusted for BMI.
+
+ CONCLUSIONS: The present findings demonstrated a strong association between the severity of 25(OH)D deficiency and oxidative/antioxidative related parameters independently of obesity. Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1406-16-2 (Vitamin D). EC 3-1-8-1 (Aryldialkylphosphatase). EC 3-1-8-1 (PON1 protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.clnesp.2021.07.032
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Asghari&issn=2405-4577&title=Clinical+Nutrition+ESPEN&atitle=Vitamin+D+status+and+systemic+redox+biomarkers+in+adults+with+obesity.&volume=45&issue=&spage=292&epage=298&date=2021&doi=10.1016%2Fj.clnesp.2021.07.032&pmid=34620331&sid=OVID:medline
+
+<730>
+Unique Identifier
+ 34614058
+Title
+ Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD.
+Source
+ Brazilian Dental Journal. 32(2):27-36, 2021 Mar-Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cortelli SC; Maximo PM; Peralta FS; Silva RAD; Rovai ES; Costa FO; Aquino DR; Rodrigues E; Cortelli JR
+Author NameID
+ Cortelli, Sheila C; ORCID: http://orcid.org/0000-0003-0809-6935
+ Cortelli, Jose R; ORCID: http://orcid.org/0000-0001-5147-0705
+Authors Full Name
+ Cortelli, Sheila C; Maximo, Priscila de Macedo; Peralta, Felipe S; Silva, Rodrigo Augusto da; Rovai, Emanuel S; Costa, Fernando O; Aquino, Davi R; Rodrigues, Edson; Cortelli, Jose R.
+Institution
+ Cortelli, Sheila C. Department of Dentistry, Periodontics Research Division, University of Taubate, Taubate, Sao Paulo, Brazil.
+ Maximo, Priscila de Macedo. Department of Dentistry, Periodontics Research Division, University of Taubate, Taubate, Sao Paulo, Brazil.
+ Peralta, Felipe S. Department of Dentistry, Periodontics Research Division, University of Taubate, Taubate, Sao Paulo, Brazil.
+ Silva, Rodrigo Augusto da. Department of Dentistry, Periodontics Research Division, University of Taubate, Taubate, Sao Paulo, Brazil.
+ Rovai, Emanuel S. Department of Dentistry, Periodontics Research Division, University of Taubate, Taubate, Sao Paulo, Brazil.
+ Costa, Fernando O. Department of Dentistry, Periodontics Research Division, University of Taubate, Taubate, Sao Paulo, Brazil.
+ Aquino, Davi R. School of Dentistry, Department of Periodontology, Federal University of Minas Gerais, Brazil.
+ Rodrigues, Edson. Institute of Bioscience, Biochemistry Division, University of Taubate, Taubate, Sao Paulo, Brazil.
+ Cortelli, Jose R. Department of Dentistry, Periodontics Research Division, University of Taubate, Taubate, Sao Paulo, Brazil.
+MeSH Subject Headings
+ Biomarkers
+ Disinfection
+ Humans
+ *Nitrites
+ Obesity/co [Complications]
+ *Periodontitis
+Abstract
+ The objective of this 9-month clinical study is to assess the impact of one-stage full-mouth disinfection (FMD) on salivary nitrite levels and systemic biomarkers and its correlation with total subgingival bacterial load in obese and non-obese patients with periodontitis. In total, 94 patients (55 obese and 39 non-obese) were initially evaluated, seven were lost during follow-up, resulting in 87 individuals at the end of the study. Outcomes were assessed at baseline, 3, 6, and 9 months post periodontal treatment by FMD. Salivary nitrite levels were determined using Griess reagent. Blood samples were collected to determine C-Reactive Protein (CRP), alkaline phosphatase and fasting blood glucose. Real-time PCR was used to determine the total subgingival bacterial load. FMD protocol resulted in increased salivary nitrite levels at 6- and 9-months post-treatment in the non-obese group (p<0.05). In obese individuals, FMD treatment led to an increase in salivary nitrite levels at 6 months (p<0.05); however, at 9 months, the nitrite levels returned to baseline levels. For both groups, the highest nitrite values were observed at 6 months. In addition, in both groups, FMD was associated with a decrease in biomarkers related to systemic inflammation and cardiovascular diseases, such as CRP (p<0.05) and alkaline phosphatase (p<0.05), and had no impact on the fasting blood glucose. This study demonstrates that obese patients with periodontitis present similar salivary nitrite levels when compared with non-obese individuals. FMD protocol resulted in increases in salivary nitrite levels and was associated with a positive impact on systemic biomarkers, regardless of obesity status.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Nitrites).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1590%2f0103-6440202103782
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cortelli&issn=0103-6440&title=Brazilian+Dental+Journal&atitle=Salivary+nitrite+and+systemic+biomarkers+in+obese+individuals+with+periodontitis+submitted+to+FMD.&volume=32&issue=2&spage=27&epage=36&date=2021&doi=10.1590%2F0103-6440202103782&pmid=34614058&sid=OVID:medline
+
+<731>
+Unique Identifier
+ 34611217
+Title
+ Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity.
+Source
+ Scientific Reports. 11(1):19725, 2021 10 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mahmoudinezhad M; Farhangi MA; Kahroba H; Dehghan P
+Authors Full Name
+ Mahmoudinezhad, Mahsa; Farhangi, Mahdieh Abbasalizad; Kahroba, Houman; Dehghan, Parvin.
+Institution
+ Mahmoudinezhad, Mahsa. Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Attar-Neishabouri Ave, Golgasht St, 5165665931, Tabriz, Iran.
+ Farhangi, Mahdieh Abbasalizad. Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. abbasalizadm@tbzmed.ac.ir.
+ Kahroba, Houman. Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Dehghan, Parvin. Department of Biochemistry and Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Attar-Neishabouri Ave, Golgasht St, 5165665931, Tabriz, Iran. dehghan.nut@gmail.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Weights and Measures
+ Cross-Sectional Studies
+ *Diet
+ *Disease Susceptibility
+ *Fatty Acid Desaturases/ge [Genetics]
+ Fatty Acid Desaturases/me [Metabolism]
+ Female
+ Genetic Predisposition to Disease
+ *Genotype
+ *Glycation End Products, Advanced/ge [Genetics]
+ Glycation End Products, Advanced/me [Metabolism]
+ Humans
+ Male
+ Middle Aged
+ Models, Biological
+ *Obesity/ep [Epidemiology]
+ *Obesity/et [Etiology]
+ Public Health Surveillance
+ Risk Assessment
+ Risk Factors
+Abstract
+ Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to halt its prevalence. In this concept, considering the effect of interaction between fatty acid desaturase 2 (FADS2) gene variants and dietary advanced glycation end products (AGEs) on obesity-related characteristics seems to be challenging. The present cross-sectional study conducted among 347 obese individuals. A validated semi-quantitative 147-item food frequency questionnaire (FFQ) was used to estimate dietary intakes and American multiethnic database was used to calculate AGEs content of food items which were not available in Iranian Food Composition Table (FCT). FADS2 gene variants were determined according to Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Analysis of covariance (ANCOVA) was used to evaluate the modifier effect of FADS2 gene-dietary AGEs on biochemical values. Based on our findings, no significant differences was reported in term of biochemical variables between AGEs tertiles. In contrast, percent of macronutrients (carbohydrate, protein and fat) of total calorie intake, amount of daily intake of fiber and meat groups showed a significant differences among AGEs tertiles. Furthermore, statistical assays clarified the modifier effects of FADS2 gene-AGEs on weight (Pinteraction = 0.04), fat mass (Pinteraction = 0.03), waist circumference (Pinteraction = 0.008) and cholesterol (Pinteraction = 0.04) level. Accordingly, higher consumption of protein or fat based foods constitute high amount of AGEs and heterozygote genotype for FADS2 tended to show lower level of AGEs content. These findings address further investigation to develop new approaches for nutritional interventions. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycation End Products, Advanced). EC 1-14-19 (Fatty Acid Desaturases). EC 1-14-19-3 (FADS2 protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-99077-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mahmoudinezhad&issn=2045-2322&title=Scientific+Reports&atitle=Personalized+diet+study+of+dietary+advanced+glycation+end+products+%28AGEs%29+and+fatty+acid+desaturase+2+%28FADS2%29+genotypes+in+obesity.&volume=11&issue=1&spage=19725&epage=&date=2021&doi=10.1038%2Fs41598-021-99077-3&pmid=34611217&sid=OVID:medline
+
+<732>
+Unique Identifier
+ 34603196
+Title
+ Serum Afamin a Novel Marker of Increased Hepatic Lipid Content.
+Source
+ Frontiers in Endocrinology. 12:670425, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kurdiova T; Balaz M; Kovanicova Z; Zemkova E; Kuzma M; Belan V; Payer J; Gasperikova D; Dieplinger H; Ukropcova B; Ukropec J
+Authors Full Name
+ Kurdiova, Timea; Balaz, Miroslav; Kovanicova, Zuzana; Zemkova, Erika; Kuzma, Martin; Belan, Vitazoslav; Payer, Juraj; Gasperikova, Daniela; Dieplinger, Hans; Ukropcova, Barbara; Ukropec, Jozef.
+Institution
+ Kurdiova, Timea. Department of Metabolic Disease Research, Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Balaz, Miroslav. Department of Metabolic Disease Research, Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Kovanicova, Zuzana. Department of Metabolic Disease Research, Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Zemkova, Erika. Department of Biological and Medical Sciences, Faculty of Physical Education and Sports, Comenius University, Bratislava, Slovakia.
+ Kuzma, Martin. 5th Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
+ Belan, Vitazoslav. MRI Unit, Pro Diagnostic Group, Bratislava, Slovakia.
+ Payer, Juraj. 5th Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
+ Gasperikova, Daniela. Department of Metabolic Disease Research, Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Dieplinger, Hans. Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
+ Ukropcova, Barbara. Department of Metabolic Disease Research, Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Ukropcova, Barbara. Department of Clinical Pathophysiology, Faculty of Medicine, Institute of Pathophysiology, Comenius University, Bratislava, Slovakia.
+ Ukropec, Jozef. Department of Metabolic Disease Research, Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ *Carrier Proteins/bl [Blood]
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Fatty Liver/bl [Blood]
+ *Fatty Liver/di [Diagnosis]
+ Female
+ Follow-Up Studies
+ *Glycoproteins/bl [Blood]
+ Humans
+ Insulin Resistance
+ Lipid Metabolism
+ Male
+ *Obesity/pp [Physiopathology]
+ Prediabetic State/bl [Blood]
+ *Prediabetic State/di [Diagnosis]
+ Prognosis
+ Serum Albumin, Human
+Keyword Heading
+ afamin
+ exercise
+ hepatic lipids
+ insulin resistance
+ prediabetes
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aim: Afamin is a liver-produced glycoprotein, a potential early marker of metabolic syndrome. Here we investigated regulation of afamin in a course of the metabolic disease development and in response to 3-month exercise intervention.
+
+ Methods: We measured whole-body insulin sensitivity (euglycemic hyperinsulinemic clamp), glucose tolerance, abdominal adiposity, hepatic lipid content (magnetic resonance imaging/spectroscopy), habitual physical activity (accelerometers) and serum afamin (enzyme-linked immunosorbent assay) in 71 middle-aged men with obesity, prediabetes and newly diagnosed type 2 diabetes. Effects of 3-month exercise were investigated in 22 overweight-to-obese middle-aged individuals (16M/6F).
+
+ Results: Prediabetes and type 2 diabetes, but not obesity, were associated with increased serum afamin (p<0.001). Afamin correlated positively with hepatic lipids, fatty liver index and liver damage markers; with parameters of adiposity (waist circumference, %body fat, adipocyte diameter) and insulin resistance (fasting insulin, C-peptide, HOMA-IR; p<0.001 all). Moreover, afamin negatively correlated with whole-body insulin sensitivity (M-value/Insulin, p<0.001). Hepatic lipids and fasting insulinemia were the most important predictors of serum afamin, explaining >63% of its variability. Exercise-related changes in afamin were paralleled by reciprocal changes in insulinemia, insulin resistance and visceral adiposity. No significant change in hepatic lipid content was observed.
+
+ Conclusions: Subjects with prediabetes and type 2 diabetes had the highest serum afamin levels. Afamin was more tightly related to hepatic lipid accumulation, liver damage and insulin resistance than to obesity. Copyright © 2021 Kurdiova, Balaz, Kovanicova, Zemkova, Kuzma, Belan, Payer, Gasperikova, Dieplinger, Ukropcova and Ukropec.
+Registry Number/Name of Substance
+ 0 (AFM protein, human). 0 (Biomarkers). 0 (Carrier Proteins). 0 (Glycoproteins). ZIF514RVZR (Serum Albumin, Human).
+Publication Type
+ Clinical Trial. Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.670425
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kurdiova&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Serum+Afamin+a+Novel+Marker+of+Increased+Hepatic+Lipid+Content.&volume=12&issue=&spage=670425&epage=&date=2021&doi=10.3389%2Ffendo.2021.670425&pmid=34603196&sid=OVID:medline
+
+<733>
+Unique Identifier
+ 34599972
+Title
+ Association of circulating metabolites with incident type 2 diabetes in an obese population from a national cohort.
+Source
+ Diabetes Research & Clinical Practice. 180:109077, 2021 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee KS; Rim JH; Lee YH; Lee SG; Lim JB; Kim JH
+Authors Full Name
+ Lee, Kwang Seob; Rim, John Hoon; Lee, Yong-Ho; Lee, Sang-Guk; Lim, Jong-Baeck; Kim, Jeong-Ho.
+Institution
+ Lee, Kwang Seob. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
+ Rim, John Hoon. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
+ Lee, Yong-Ho. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
+ Lee, Sang-Guk. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: comforter6@yuhs.ac.
+ Lim, Jong-Baeck. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
+ Kim, Jeong-Ho. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
+MeSH Subject Headings
+ Biomarkers
+ Cohort Studies
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Humans
+ Metabolomics
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Risk Factors
+Keyword Heading
+ Diabetes mellitus
+ Metabolomics
+ Obesity
+ Prediction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Obesity is the most common risk factor for type 2 diabetes. However, not all obese individuals develop diabetes. In the era of precision medicine, metabolomics may reveal the fundamental metabolic status of an individual. Our aim was to assess the association of metabolites with incident type 2 diabetes in obese individuals using Korean Genome and Epidemiology Cohort Study.
+
+ METHODS: Using 12 years of metabolomic data from 2,580 individuals, we performed a metabolomic study to define metabolically healthy obesity in an obese population (n = 704) with incident type 2 diabetes. Cox proportional hazards regression model and survival analysis were performed adjusted for the traditional risk factors of type 2 diabetes.
+
+ RESULTS: Our study revealed that spermine, acyl-alkyl phosphatidylcholines (C34:3, C36:3, C42:1), hydroxy sphingomyelin (C22:2, C14:1), and sphingomyelin (C16:0) were associated with incident type 2 diabetes in obese individuals after the adjustment for risk factors and correction of multiple comparisons by Bonferroni method. Five metabolites (except hydroxy sphingomyelin C14:1 and sphingomyelin C16:0) were also significantly associated with incident type 2 diabetes in lean individuals.
+
+ CONCLUSIONS: This study highlights the need for defining metabolically healthy obesity based on serum metabolites and elucidates potential biomarkers for type 2 diabetes in an obese population. Copyright © 2021 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.diabres.2021.109077
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=0168-8227&title=Diabetes+Research+%26+Clinical+Practice&atitle=Association+of+circulating+metabolites+with+incident+type+2+diabetes+in+an+obese+population+from+a+national+cohort.&volume=180&issue=&spage=109077&epage=&date=2021&doi=10.1016%2Fj.diabres.2021.109077&pmid=34599972&sid=OVID:medline
+
+<734>
+Unique Identifier
+ 34586066
+Title
+ APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population.
+Source
+ eLife. 10, 2021 09 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Garcia AR; Finch C; Gatz M; Kraft T; Eid Rodriguez D; Cummings D; Charifson M; Buetow K; Beheim BA; Allayee H; Thomas GS; Stieglitz J; Gurven MD; Kaplan H; Trumble BC
+Author NameID
+ Garcia, Angela R; ORCID: https://orcid.org/0000-0002-6685-5533
+ Finch, Caleb; ORCID: https://orcid.org/0000-0002-7617-3958
+ Gatz, Margaret; ORCID: https://orcid.org/0000-0002-1071-9970
+ Allayee, Hooman; ORCID: https://orcid.org/0000-0002-2384-5239
+ Stieglitz, Jonathan; ORCID: https://orcid.org/0000-0001-5985-9643
+ Gurven, Michael D; ORCID: https://orcid.org/0000-0002-5661-527X
+Authors Full Name
+ Garcia, Angela R; Finch, Caleb; Gatz, Margaret; Kraft, Thomas; Eid Rodriguez, Daniel; Cummings, Daniel; Charifson, Mia; Buetow, Kenneth; Beheim, Bret A; Allayee, Hooman; Thomas, Gregory S; Stieglitz, Jonathan; Gurven, Michael D; Kaplan, Hillard; Trumble, Benjamin C.
+Institution
+ Garcia, Angela R. Center for Evolution and Medicine, Arizona State University, Tempe, United States.
+ Garcia, Angela R. Department of Anthropology, Emory University, Atlanta, United States.
+ Finch, Caleb. Leonard Davis School of Gerontology, Dornsife College, University of Southern California, Los Angeles, Los Angeles, United States.
+ Gatz, Margaret. Center for Economic and Social Research, University of Southern California, Los Angeles, Los Angeles, United States.
+ Kraft, Thomas. Department of Anthropology, University of California, Santa Barbara, Santa Barbara, United States.
+ Eid Rodriguez, Daniel. Department of Medicine, Universidad de San Simon, Cochabamba, Bolivia.
+ Cummings, Daniel. Institute for Economics and Society, Chapman University, Orange, United States.
+ Charifson, Mia. Vilcek Institute of Graduate Biomedical Sciences, New York University, New York, United States.
+ Buetow, Kenneth. Center for Evolution and Medicine, Arizona State University, Tempe, United States.
+ Buetow, Kenneth. School of Life Sciences, Arizona State University, Tempe, United States.
+ Beheim, Bret A. Department of Human Behavior, Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
+ Allayee, Hooman. Department of Preventive Medicine and Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Irvine, Irvine, United States.
+ Allayee, Hooman. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Irvine, Irvine, United States.
+ Thomas, Gregory S. Long Beach Memorial, Long Beach and University of California Irvine, Irvine, United States.
+ Stieglitz, Jonathan. Institute for Advanced Study in Toulouse, Universite Toulouse, Toulouse, France.
+ Gurven, Michael D. Department of Anthropology, University of California, Santa Barbara, Santa Barbara, United States.
+ Kaplan, Hillard. Institute for Economics and Society, Chapman University, Orange, United States.
+ Trumble, Benjamin C. School of Human Evolution and Social Change, Arizona State University, Tempe, United States.
+MeSH Subject Headings
+ *Apolipoprotein E4/ge [Genetics]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Bolivia
+ Diet
+ Female
+ Genotype
+ Humans
+ *Immunity, Innate
+ *Indians, South American
+ Life Style
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Risk Factors
+ *Tropical Climate
+Keyword Heading
+ APOE
+ Alzheimer's disease
+ cardiovascular disease
+ cholesterol
+ dementia
+ evolutionary biology
+ human
+ inflammation
+ medicine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N = 1266, 50% female), APOE4 is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized LDL and inflammation which were limited to obese adults. Further, APOE4 carriers maintain higher levels of total and LDL cholesterol at low body mass indices (BMIs). These results suggest that the relationship between APOE4 and lipids may be beneficial for pathogen-driven immune responses and unlikely to increase cardiovascular risk in an active subsistence population. Copyright © 2021, Garcia et al.
+Other Abstract
+ plain-language-summary
+ Genes contain the instructions needed for a cell to make molecules called proteins, which perform various roles in the body. Different variants of a gene can affect how the protein works, and in some cases, can increase a person's risk to develop certain diseases. For example, people who carry a version of the apolipoprotein E gene called APOE4 have a greater risk of developing Alzheimer's disease or heart disease. Individuals with two copies of this genetic variant have a 45% higher risk of heart disease and 12 times higher risk of Alzheimer's disease. Studies in industrialized countries suggest this increased risk may be the result of higher cholesterol and inflammation in people with APOE4. But if APOE4 is harmful, why does it continue to be so common worldwide? One potential explanation is that APOE4, which has been around since before modern humans, may be beneficial in some contexts. Cholesterol is essential for many vital tasks in the body. In physically demanding environments where parasitic infections are common - conditions similar to those experienced by early humans - APOE4 might be beneficial. Under those circumstances, having more cholesterol might help fuel metabolic activities, fight infections, or reduce inflammation caused by infections. Garcia et al. investigated the link between the APOE4 genetic variant, cholesterol and inflammation in 1,266 Indigenous Tsimane people from 80 villages in Bolivia. Tsimane people live an active lifestyle foraging and farming for food. Parasite infections are a common problem in their communities, but obesity rates are very low. Garcia et al. found that Tsimane people with at least one copy of the APOE4 have lower levels of inflammation and higher levels of cholesterol than those who have two copies of the APOE3 version of the gene. Very lean people with APOE4 had especially high levels of the so called "bad" low density lipoprotein (LDL) cholesterol compared to people with APOE3 only. However, in this situation, storing a little extra cholesterol may not be so bad. The findings contradict other studies that have linked obesity to higher LDL levels and APOE4 to higher levels of inflammation. For the majority of human history, humans lived in more physically strenuous and calorically restrictive environments, with less access to clean water. Garcia et al. suggest that the harmful effects of APOE4 seen in studies in more industrialized societies - where people tend to be more sedentary and have less exposure to pathogens - may reflect a mismatch between a person's environment and their genes. More studies that capture the diversity of environmental conditions under which people live will help clarify the role of APOE4 health and disease.
+ Language: English
+Registry Number/Name of Substance
+ 0 (Apolipoprotein E4). 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.7554%2feLife.68231
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Garcia&issn=2050-084X&title=eLife&atitle=APOE4+is+associated+with+elevated+blood+lipids+and+lower+levels+of+innate+immune+biomarkers+in+a+tropical+Amerindian+subsistence+population.&volume=10&issue=&spage=&epage=&date=2021&doi=10.7554%2FeLife.68231&pmid=34586066&sid=OVID:medline
+
+<735>
+Unique Identifier
+ 34583686
+Title
+ Diabetes status-related differences in risk factors and mediators of heart failure in the general population: results from the MORGAM/BiomarCaRE consortium.
+Source
+ Cardiovascular Diabetology. 20(1):195, 2021 09 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vuori MA; Reinikainen J; Soderberg S; Bergdahl E; Jousilahti P; Tunstall-Pedoe H; Zeller T; Westermann D; Sans S; Linneberg A; Iacoviello L; Costanzo S; Salomaa V; Blankenberg S; Kuulasmaa K; Niiranen TJ
+Author NameID
+ Vuori, Matti A; ORCID: https://orcid.org/0000-0003-2529-3332
+Authors Full Name
+ Vuori, Matti A; Reinikainen, Jaakko; Soderberg, Stefan; Bergdahl, Ellinor; Jousilahti, Pekka; Tunstall-Pedoe, Hugh; Zeller, Tanja; Westermann, Dirk; Sans, Susana; Linneberg, Allan; Iacoviello, Licia; Costanzo, Simona; Salomaa, Veikko; Blankenberg, Stefan; Kuulasmaa, Kari; Niiranen, Teemu J.
+Institution
+ Vuori, Matti A. Division of Medicine, University of Turku and Turku University Hospital, Kiinanmyllynkatu 2, 20521, Turku, Finland. makvuo@utu.fi.
+ Vuori, Matti A. Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland. makvuo@utu.fi.
+ Reinikainen, Jaakko. Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
+ Soderberg, Stefan. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Bergdahl, Ellinor. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Jousilahti, Pekka. Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
+ Tunstall-Pedoe, Hugh. Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, UK.
+ Zeller, Tanja. University Heart Center Hamburg, Hamburg, Germany.
+ Westermann, Dirk. University Heart Center Hamburg, Hamburg, Germany.
+ Sans, Susana. Catalan Department of Health, Barcelona, Spain.
+ Linneberg, Allan. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
+ Linneberg, Allan. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Iacoviello, Licia. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
+ Iacoviello, Licia. Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
+ Costanzo, Simona. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Salomaa, Veikko. Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
+ Blankenberg, Stefan. University Heart Center Hamburg, Hamburg, Germany.
+ Kuulasmaa, Kari. Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
+ Niiranen, Teemu J. Division of Medicine, University of Turku and Turku University Hospital, Kiinanmyllynkatu 2, 20521, Turku, Finland.
+ Niiranen, Teemu J. Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ *Diabetes Mellitus/ep [Epidemiology]
+ Europe/ep [Epidemiology]
+ Female
+ Health Status
+ Heart Disease Risk Factors
+ Heart Failure/bl [Blood]
+ Heart Failure/di [Diagnosis]
+ *Heart Failure/ep [Epidemiology]
+ Humans
+ Incidence
+ Inflammation Mediators/bl [Blood]
+ Male
+ Middle Aged
+ Natriuretic Peptide, Brain/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Peptide Fragments/bl [Blood]
+ Prevalence
+ Prognosis
+ Risk Assessment
+ Time Factors
+ Troponin I/bl [Blood]
+Keyword Heading
+ Biomarker
+ Cardiovascular disease
+ Diabetes
+ Hazard
+ Heart failure
+ Mediation
+ Risk
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The risk of heart failure among diabetic individuals is high, even under tight glycemic control. The correlates and mediators of heart failure risk in individuals with diabetes need more elucidation in large population-based cohorts with long follow-up times and a wide panel of biologically relevant biomarkers.
+
+ METHODS: In a population-based sample of 3834 diabetic and 90,177 non-diabetic individuals, proportional hazards models and mediation analysis were used to assess the relation of conventional heart failure risk factors and biomarkers with incident heart failure.
+
+ RESULTS: Over a median follow-up of 13.8 years, a total of 652 (17.0%) and 5524 (6.1%) cases of incident heart failure were observed in participants with and without diabetes, respectively. 51.4% were women and the mean age at baseline was 48.7 (standard deviation [SD] 12.5) years. The multivariable-adjusted hazard ratio (HR) for heart failure among diabetic individuals was 2.70 (95% confidence interval, 2.49-2.93) compared to non-diabetic participants. In the multivariable-adjusted Cox models, conventional cardiovascular disease risk factors, such as smoking (diabetes: HR 2.07 [1.59-2.69]; non-diabetes: HR 1.85 [1.68-2.02]), BMI (diabetes: HR 1.30 [1.18-1.42]; non-diabetes: HR 1.40 [1.35-1.47]), baseline myocardial infarction (diabetes: HR 2.06 [1.55-2.75]; non-diabetes: HR 2.86 [2.50-3.28]), and baseline atrial fibrillation (diabetes: HR 1.51 [0.82-2.80]; non-diabetes: HR 2.97 [2.21-4.00]) had the strongest associations with incident heart failure. In addition, biomarkers for cardiac strain (represented by nT-proBNP, diabetes: HR 1.26 [1.19-1.34]; non-diabetes: HR 1.43 [1.39-1.47]), myocardial injury (hs-TnI, diabetes: HR 1.10 [1.04-1.16]; non-diabetes: HR 1.13 [1.10-1.16]), and inflammation (hs-CRP, diabetes: HR 1.13 [1.03-1.24]; non-diabetes: HR 1.29 [1.25-1.34]) were also associated with incident heart failure. In general, all these associations were equally strong in non-diabetic and diabetic individuals. However, the strongest mediators of heart failure in diabetes were the direct effect of diabetes status itself (relative effect share 43.1% [33.9-52.3] and indirect effects (effect share 56.9% [47.7-66.1]) mediated by obesity (BMI, 13.2% [10.3-16.2]), cardiac strain/volume overload (nT-proBNP, 8.4% [-0.7-17.4]), and hyperglycemia (glucose, 12.0% [4.2-19.9]).
+
+ CONCLUSIONS: The findings suggest that the main mediators of heart failure in diabetes are obesity, hyperglycemia, and cardiac strain/volume overload. Conventional cardiovascular risk factors are strongly related to incident heart failure, but these associations are not stronger in diabetic than in non-diabetic individuals. Active measurement of relevant biomarkers could potentially be used to improve prevention and prediction of heart failure in high-risk diabetic patients. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Inflammation Mediators). 0 (Peptide Fragments). 0 (Troponin I). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12933-021-01378-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vuori&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Diabetes+status-related+differences+in+risk+factors+and+mediators+of+heart+failure+in+the+general+population%3A+results+from+the+MORGAM%2FBiomarCaRE+consortium.&volume=20&issue=1&spage=195&epage=&date=2021&doi=10.1186%2Fs12933-021-01378-4&pmid=34583686&sid=OVID:medline
+
+<736>
+Unique Identifier
+ 34578793
+Title
+ Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice.
+Source
+ Nutrients. 13(9), 2021 Aug 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Power Guerra N; Parveen A; Buhler D; Brauer DL; Muller L; Pilz K; Witt M; Glass A; Bajorat R; Janowitz D; Wolkenhauer O; Vollmar B; Kuhla A
+Author NameID
+ Power Guerra, Nicole; ORCID: https://orcid.org/0000-0001-6036-7574
+ Brauer, David Leon; ORCID: https://orcid.org/0000-0002-3096-8712
+ Muller, Luisa; ORCID: https://orcid.org/0000-0001-7942-3273
+ Witt, Martin; ORCID: https://orcid.org/0000-0002-4538-877X
+Authors Full Name
+ Power Guerra, Nicole; Parveen, Alisha; Buhler, Daniel; Brauer, David Leon; Muller, Luisa; Pilz, Kristin; Witt, Martin; Glass, Anne; Bajorat, Rika; Janowitz, Deborah; Wolkenhauer, Olaf; Vollmar, Brigitte; Kuhla, Angela.
+Institution
+ Power Guerra, Nicole. Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Centre, Schillingallee 69a, 18057 Rostock, Germany.
+ Power Guerra, Nicole. Department of Anatomy, Rostock University Medical Centre, Gertrudenstrase 9, 18057 Rostock, Germany.
+ Parveen, Alisha. Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Centre, Schillingallee 69a, 18057 Rostock, Germany.
+ Buhler, Daniel. Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Centre, Schillingallee 69a, 18057 Rostock, Germany.
+ Brauer, David Leon. Department of Systems Biology and Bioinformatics, University of Rostock, Ulmenstrase 69, 18057 Rostock, Germany.
+ Muller, Luisa. Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Centre, Schillingallee 69a, 18057 Rostock, Germany.
+ Muller, Luisa. Department of Psychosomatic Medicine and Psychotherapy, Rostock University Medical Centre, Gehlsheimerstrase 20, 18147 Rostock, Germany.
+ Muller, Luisa. Centre for Transdisciplinary Neurosciences Rostock (CTNR), Rostock University Medical Centre, Gehlsheimerstrase 20, 18147 Rostock, Germany.
+ Pilz, Kristin. Department of Psychiatry, University of Greifswald, Ellernholzstrase 1-2, 17489 Greifswald, Germany.
+ Witt, Martin. Department of Anatomy, Rostock University Medical Centre, Gertrudenstrase 9, 18057 Rostock, Germany.
+ Glass, Anne. Institute for Biostatistics and Informatics, Rostock University Medical Centre, Ernst-Heydemann-Strase 8, 18057 Rostock, Germany.
+ Bajorat, Rika. Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Centre, Schillingallee 35, 18057 Rostock, Germany.
+ Janowitz, Deborah. Department of Psychiatry, University of Greifswald, Ellernholzstrase 1-2, 17489 Greifswald, Germany.
+ Wolkenhauer, Olaf. Department of Systems Biology and Bioinformatics, University of Rostock, Ulmenstrase 69, 18057 Rostock, Germany.
+ Wolkenhauer, Olaf. Leibniz-Institute for Food Systems Biology, Technical University of Munich, Lise-Meitner-Strase 34, 85354 Freising, Germany.
+ Vollmar, Brigitte. Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Centre, Schillingallee 69a, 18057 Rostock, Germany.
+ Vollmar, Brigitte. Centre for Transdisciplinary Neurosciences Rostock (CTNR), Rostock University Medical Centre, Gehlsheimerstrase 20, 18147 Rostock, Germany.
+ Kuhla, Angela. Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Centre, Schillingallee 69a, 18057 Rostock, Germany.
+ Kuhla, Angela. Centre for Transdisciplinary Neurosciences Rostock (CTNR), Rostock University Medical Centre, Gehlsheimerstrase 20, 18147 Rostock, Germany.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Diet, High-Fat
+ Elevated Plus Maze Test
+ Fasting
+ Female
+ *Fibroblast Growth Factors/bl [Blood]
+ Fibroblast Growth Factors/me [Metabolism]
+ Humans
+ *Locomotion
+ Machine Learning
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ *Obesity/bl [Blood]
+ Open Field Test
+ Physical Conditioning, Animal
+ *Smell
+ *Weight Loss
+Keyword Heading
+ FGF21
+ behaviour
+ diet-induced obesity
+ feature selection
+ high-fat diet
+ machine learning
+ time restricted feeding
+ treadmill
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is one of the most challenging diseases of the 21st century and is accompanied by behavioural disorders. Exercise, dietary adjustments, or time-restricted feeding are the only successful long-term treatments to date. Fibroblast growth factor 21 (FGF21) plays a key role in dietary regulation, but FGF21 resistance is prevalent in obesity. The aim of this study was to investigate in obese mice whether weight reduction leads to improved behaviour and whether these behavioural changes are associated with decreased plasma FGF21 levels. After establishing a model for diet-induced obesity, mice were subjected to three different interventions for weight reduction, namely dietary change, treadmill exercise, or time-restricted feeding. In this study, we demonstrated that only the combination of dietary change and treadmill exercise affected all parameters leading to a reduction in weight, fat, and FGF21, as well as less anxious behaviour, higher overall activity, and improved olfactory detection abilities. To investigate the interrelationship between FGF21 and behavioural parameters, feature selection algorithms were applied designating FGF21 and body weight as one of five highly weighted features. In conclusion, we concluded from the complementary methods that FGF21 can be considered as a potential biomarker for improved behaviour in obese mice after weight reduction.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13092916
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Power+Guerra&issn=2072-6643&title=Nutrients&atitle=Fibroblast+Growth+Factor+21+as+a+Potential+Biomarker+for+Improved+Locomotion+and+Olfaction+Detection+Ability+after+Weight+Reduction+in+Obese+Mice.&volume=13&issue=9&spage=&epage=&date=2021&doi=10.3390%2Fnu13092916&pmid=34578793&sid=OVID:medline
+
+<737>
+Unique Identifier
+ 34576066
+Title
+ Papain Ameliorates Lipid Accumulation and Inflammation in High-Fat Diet-Induced Obesity Mice and 3T3-L1 Adipocytes via AMPK Activation.
+Source
+ International Journal of Molecular Sciences. 22(18), 2021 Sep 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kang YM; Kang HA; Cominguez DC; Kim SH; An HJ
+Author NameID
+ An, Hyo-Jin; ORCID: https://orcid.org/0000-0002-2937-874X
+Authors Full Name
+ Kang, Yun-Mi; Kang, Hyun-Ae; Cominguez, Divina C; Kim, Su-Hyun; An, Hyo-Jin.
+Institution
+ Kang, Yun-Mi. Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju 26339, Gangwon-do, Korea.
+ Kang, Hyun-Ae. Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju 26339, Gangwon-do, Korea.
+ Cominguez, Divina C. Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju 26339, Gangwon-do, Korea.
+ Kim, Su-Hyun. Department of Obstetrics and Gynecology, College of Korean Medicine, Sangji University, Wonju 26339, Gangwon-do, Korea.
+ An, Hyo-Jin. Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju 26339, Gangwon-do, Korea.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ *AMP-Activated Protein Kinases/me [Metabolism]
+ Adipocytes/de [Drug Effects]
+ Adipocytes/me [Metabolism]
+ *Adipocytes/pa [Pathology]
+ Adipogenesis/de [Drug Effects]
+ Adipokines/me [Metabolism]
+ Adiposity/de [Drug Effects]
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ *Diet, High-Fat
+ Enzyme Activation/de [Drug Effects]
+ Fatty Liver/pa [Pathology]
+ Forkhead Box Protein O1/me [Metabolism]
+ Hypertrophy
+ *Inflammation/pa [Pathology]
+ *Lipid Metabolism/de [Drug Effects]
+ Lipids/bl [Blood]
+ Liver/de [Drug Effects]
+ Liver/pa [Pathology]
+ Macrophages/de [Drug Effects]
+ Macrophages/pa [Pathology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ *Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Organ Size/de [Drug Effects]
+ *Papain/pd [Pharmacology]
+ Sirtuin 1/me [Metabolism]
+Keyword Heading
+ 3T3-L1 preadipocytes
+ AMP-activated protein kinase
+ Carica papaya
+ adipogenesis
+ high-fat diet
+ inflammation
+ obesity
+ papain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Papain is a proteolytic enzyme present in the leaves, fruits, roots, and latex of the Carica papaya (papaya) plant. Although it exhibits a wide range of activities, there are no reports on the anti-obesity effects of papain. This study examined the anti-obesity effect and obesity-involved anti-inflammatory mechanism of papain in in vivo and in vitro models using high-fat diet (HFD)-induced obese mice and 3T3-L1 preadipocytes. Oral administration of papain reduced HFD-induced weight of the body, liver, and adipose tissues of mice. Papain also reduced hepatic lipid accumulation and adipocyte size. Moreover, serum total cholesterol and triglyceride levels were markedly reduced in papain-treated mice. In addition, papain inhibited the differentiation of preadipocytes and oil accumulation in 3T3-L1 preadipocytes and rat primary preadipocytes. Mechanistically, papain significantly downregulated the protein levels of key adipogenesis regulators and reversed the expression of pro-inflammatory cytokines and adipokines in HFD-induced obese mice and 3T3-L1 preadipocytes. Papain also markedly enhanced activation of the AMP-activated protein kinase pathway in both models. Collectively, these results suggest that papain exerts anti-obesity effects in HFD-induced mice and 3T3-L1 preadipocytes by regulating levels of adipogenic factors involved in lipid metabolism and inflammation; thus, it could be useful in the prevention and treatment of obesity.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Forkhead Box Protein O1). 0 (Foxo1 protein, mouse). 0 (Lipids). EC 2-7-11-31 (AMP-Activated Protein Kinases). EC 3-4-22-2 (Papain). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22189885
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kang&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Papain+Ameliorates+Lipid+Accumulation+and+Inflammation+in+High-Fat+Diet-Induced+Obesity+Mice+and+3T3-L1+Adipocytes+via+AMPK+Activation.&volume=22&issue=18&spage=9885&epage=&date=2021&doi=10.3390%2Fijms22189885&pmid=34576066&sid=OVID:medline
+
+<738>
+Unique Identifier
+ 34552205
+Title
+ Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes.
+Source
+ Experimental & Molecular Medicine. 53(9):1390-1401, 2021 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kang HJ; Min BK; Choi WI; Jeon JH; Kim DW; Park S; Lee YK; Kim HJ; Byeon JE; Go Y; Ham HJ; Jeon YH; Kim MJ; Lee JY; Wende AR; Choi SH; Harris RA; Lee IK
+Author NameID
+ Park, Sungmi; ORCID: http://orcid.org/0000-0002-3074-5914
+ Wende, Adam R; ORCID: http://orcid.org/0000-0002-5536-4675
+Authors Full Name
+ Kang, Hyeon-Ji; Min, Byong-Keol; Choi, Won-Il; Jeon, Jae-Han; Kim, Dong Wook; Park, Sungmi; Lee, Yun-Kyung; Kim, Hwa-Jin; Byeon, Ju-Eun; Go, Younghoon; Ham, Hye Jin; Jeon, Yong Hyun; Kim, Mi-Jin; Lee, Jung Yi; Wende, Adam R; Choi, Sung Hee; Harris, Robert A; Lee, In-Kyu.
+Institution
+ Kang, Hyeon-Ji. Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.
+ Min, Byong-Keol. Arbormed Co., Ltd., Seoul, Republic of Korea.
+ Choi, Won-Il. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
+ Choi, Won-Il. Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
+ Jeon, Jae-Han. Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.
+ Jeon, Jae-Han. Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
+ Kim, Dong Wook. Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
+ Kim, Dong Wook. Department of Biochemistry, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
+ Park, Sungmi. Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
+ Lee, Yun-Kyung. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
+ Kim, Hwa-Jin. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
+ Byeon, Ju-Eun. BK21 Plus KNU Biomedical Convergence Programs, Department of Biomedical Science, Kyungpook National University, Daegu, Republic of Korea.
+ Byeon, Ju-Eun. Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu, Republic of Korea.
+ Go, Younghoon. Korean Medicine Application Center, Korea Institute of Oriental Medicine, Daegu, Republic of Korea.
+ Ham, Hye Jin. Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
+ Jeon, Yong Hyun. Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
+ Jeon, Yong Hyun. Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea.
+ Kim, Mi-Jin. Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.
+ Lee, Jung Yi. Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
+ Wende, Adam R. Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Choi, Sung Hee. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. drshchoi@snu.ac.kr.
+ Harris, Robert A. Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, KS, USA. raharris@iu.edu.
+ Lee, In-Kyu. Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea. leei@knu.ac.kr.
+ Lee, In-Kyu. Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea. leei@knu.ac.kr.
+ Lee, In-Kyu. Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea. leei@knu.ac.kr.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ Adipocytes/cy [Cytology]
+ *Adipocytes/me [Metabolism]
+ *Adipogenesis/ge [Genetics]
+ Adiposity/ge [Genetics]
+ Animals
+ Biomarkers
+ *Cell Differentiation/ge [Genetics]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Gene Expression
+ Glycolysis
+ Insulin Resistance
+ Lactic Acid/me [Metabolism]
+ Mice
+ Mice, Knockout
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Organ Size
+ *Pyruvate Dehydrogenase Acetyl-Transferring Kinase/df [Deficiency]
+Abstract
+ Obesity is now recognized as a disease. This study revealed a novel role for pyruvate dehydrogenase kinase (PDK) in diet-induced hypertrophic obesity. Mice with global or adipose tissue-specific PDK2 deficiency were protected against diet-induced obesity. The weight of adipose tissues and the size of adipocytes were reduced. Adipocyte-specific PDK2 deficiency slightly increased insulin sensitivity in HFD-fed mice. In studies with 3T3-L1 preadipocytes, PDK2 and PDK1 expression was strongly increased during adipogenesis. Evidence was found for epigenetic induction of both PDK1 and PDK2. Gain- and loss-of-function studies with 3T3-L1 cells revealed a critical role for PDK1/2 in adipocyte differentiation and lipid accumulation. PDK1/2 induction during differentiation was also accompanied by increased expression of hypoxia-inducible factor-1alpha (HIF1alpha) and enhanced lactate production, both of which were absent in the context of PDK1/2 deficiency. Exogenous lactate supplementation increased the stability of HIF1alpha and promoted adipogenesis. PDK1/2 overexpression-mediated adipogenesis was abolished by HIF1alpha inhibition, suggesting a role for the PDK-lactate-HIF1alpha axis during adipogenesis. In human adipose tissue, the expression of PDK1/2 was positively correlated with that of the adipogenic marker PPARgamma and inversely correlated with obesity. Similarly, PDK1/2 expression in mouse adipose tissue was decreased by chronic high-fat diet feeding. We conclude that PDK1 and 2 are novel regulators of adipogenesis that play critical roles in obesity. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Pdk1 protein, mouse). 0 (Pdk2 protein, mouse). 0 (Pyruvate Dehydrogenase Acetyl-Transferring Kinase). 33X04XA5AT (Lactic Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs12276-021-00672-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kang&issn=1226-3613&title=Experimental+%26+Molecular+Medicine&atitle=Pyruvate+dehydrogenase+kinase+1+and+2+deficiency+reduces+high-fat+diet-induced+hypertrophic+obesity+and+inhibits+the+differentiation+of+preadipocytes+into+mature+adipocytes.&volume=53&issue=9&spage=1390&epage=1401&date=2021&doi=10.1038%2Fs12276-021-00672-1&pmid=34552205&sid=OVID:medline
+
+<739>
+Unique Identifier
+ 34548089
+Title
+ Effects of an 8-week aerobic exercise program on plasma markers for cholesterol absorption and synthesis in older overweight and obese men.
+Source
+ Lipids in Health & Disease. 20(1):112, 2021 Sep 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mashnafi S; Plat J; Mensink RP; Joris PJ; Kleinloog JPD; Baumgartner S
+Authors Full Name
+ Mashnafi, S; Plat, J; Mensink, R P; Joris, P J; Kleinloog, J P D; Baumgartner, S.
+Institution
+ Mashnafi, S. Department of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
+ Mashnafi, S. Department of Medical Basic Sciences, Faculty of Applied Medical Sciences, AlBaha University, AlBaha, Saudi Arabia.
+ Plat, J. Department of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
+ Mensink, R P. Department of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
+ Joris, P J. Department of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
+ Kleinloog, J P D. Department of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
+ Baumgartner, S. Department of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands. sabine.baumgartner@maastrichtuniversity.nl.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Cholesterol/aa [Analogs & Derivatives]
+ *Cholesterol/bl [Blood]
+ Cholesterol/ch [Chemistry]
+ Cross-Over Studies
+ *Exercise
+ *Exercise Therapy/mt [Methods]
+ Humans
+ Life Style
+ Male
+ Middle Aged
+ *Obesity/th [Therapy]
+ *Overweight/th [Therapy]
+ Phytosterols/bl [Blood]
+ Sterols/bl [Blood]
+ Surveys and Questionnaires
+Keyword Heading
+ Aerobic exercise
+ Cholesterol absorption
+ Cholesterol metabolism
+ Cholesterol precursors
+ Cholesterol synthesis
+ Non-cholesterol sterols
+ Plant sterols
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Increased physical activity is inversely related to the risk to develop cardiovascular disease (CVD). In a recent systematic review, it was reported that CVD patients had an increased cholesterol absorption and a decreased synthesis as compared with control participants. As increased physical activity levels reduce CVD risk, we hypothesized that exercise training will reduce cholesterol absorption and increase endogenous cholesterol synthesis in older overweight and obese men.
+
+ METHODS: A randomized, controlled, crossover trial was performed. Seventeen apparently healthy older overweight and obese men were randomized to start with an aerobic exercise or no-exercise control period for 8 weeks, separated by 12 weeks washout. Fasting serum total cholesterol (TC) and non-cholesterol sterol concentrations were measured at baseline, and after 4 and 8 weeks.
+
+ RESULTS: The aerobic exercise program did not affect serum TC concentrations. In addition, exercise did not affect TC-standardized serum concentrations of sitosterol and cholestanol that are markers for cholesterol absorption. However, a trend for reduced TC-standardized campesterol concentrations, which is another validated marker for cholesterol absorption, was observed as compared with control. Lathosterol concentrations, reflecting cholesterol synthesis, did not differ between both periods.
+
+ CONCLUSIONS: Aerobic exercise training for 8 weeks did not lower serum TC concentrations in older overweight and obese men, but a trend towards a decrease in the cholesterol absorption marker campesterol was found. The cholesterol synthesis marker lathosterol did not change.
+
+ TRIAL REGISTRATION: posted on www.clinicaltrials.gov as NCT03272061 on 7 September 2017. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phytosterols). 0 (Sterols). 5L5O665639 (campesterol). 80-99-9 (lathosterol). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12944-021-01537-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mashnafi&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Effects+of+an+8-week+aerobic+exercise+program+on+plasma+markers+for+cholesterol+absorption+and+synthesis+in+older+overweight+and+obese+men.&volume=20&issue=1&spage=112&epage=&date=2021&doi=10.1186%2Fs12944-021-01537-2&pmid=34548089&sid=OVID:medline
+
+<740>
+Unique Identifier
+ 34543321
+Title
+ Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.
+Source
+ PLoS ONE [Electronic Resource]. 16(9):e0257352, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kitazawa A; Maeda S; Fukuda Y
+Author NameID
+ Kitazawa, Atsushi; ORCID: https://orcid.org/0000-0001-9513-6426
+Authors Full Name
+ Kitazawa, Atsushi; Maeda, Shotaro; Fukuda, Yoshiharu.
+Institution
+ Kitazawa, Atsushi. Graduate School of Public Health, Teikyo University, Tokyo, Japan.
+ Kitazawa, Atsushi. Department of Nephrology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.
+ Maeda, Shotaro. Graduate School of Public Health, Teikyo University, Tokyo, Japan.
+ Fukuda, Yoshiharu. Graduate School of Public Health, Teikyo University, Tokyo, Japan.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers
+ Data Management
+ Female
+ Humans
+ Incidence
+ Insurance, Health
+ Japan/ep [Epidemiology]
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Obesity/co [Complications]
+ Prediabetic State/me [Metabolism]
+ *Predictive Value of Tests
+ Regression Analysis
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ Sensitivity and Specificity
+ *Severity of Illness Index
+ Treatment Outcome
+Abstract
+ BACKGROUND & AIMS: Fatty liver is associated with incident diabetes, and the fatty liver index (FLI) is a surrogate marker for non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether or not FLI was associated with incident diabetes in relation to obesity and prediabetic levels in the general Japanese population.
+
+ METHODS: This was a retrospective study using the Japanese health check-up database of one health insurance from FY2015 to FY2018. This study included 28,991 individuals with prediabetes. First, we stratified all participants into two groups: "high-risk," comprising patients with HbA1c >6.0%, and "standard," comprising the rest. Subsequently, we divided them into four groups according to FLI (<30 or not) and obesity (BMI <25 kg/m2 or not). Subsequently, the incidence rate of diabetes was compared among the groups after 3 years of follow-up using multiple logistic regression models after adjusting for potential confounders.
+
+ RESULTS: After 3 years of follow-up, 1,547 new cases of diabetes were found, and the cumulative incidence was 2.96% for the standard group and 26.1% for the high-risk group. In non-obese individuals, odds ratios (95% confidence interval) for FLI >=30 versus FLI <30 were: 1.44 (1.09-1.92) for the standard group and 1.42 (0.99-2.03) for the high-risk group. In the high-risk group, obesity (BMI >=25 kg/m2) but FLI <30 was not a risk factor for developing diabetes.
+
+ CONCLUSION: Although high FLI is generally considered to be a risk factor for developing diabetes, obesity might have been a confounding factor. However, the present study showed that high FLI is a risk factor for the development of diabetes, even in non-obese individuals. Our results include suggestion to develop a screening tool to effectively identify people at high risk of developing diabetes from the population (especially non-obese prediabetes) who are apparently at low health risk and are unlikely to be targeted for health guidance.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1371%2fjournal.pone.0257352
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kitazawa&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Fatty+liver+index+as+a+predictive+marker+for+the+development+of+diabetes%3A+A+retrospective+cohort+study+using+Japanese+health+check-up+data.&volume=16&issue=9&spage=e0257352&epage=&date=2021&doi=10.1371%2Fjournal.pone.0257352&pmid=34543321&sid=OVID:medline
+
+<741>
+Unique Identifier
+ 34539631
+Title
+ Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort.
+Source
+ Frontiers in Immunology. 12:700921, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pons MJ; Ymana B; Mayanga-Herrera A; Saenz Y; Alvarez-Erviti L; Tapia-Rojas S; Gamarra R; Blanco AB; Moncunill G; Ugarte-Gil MF
+Authors Full Name
+ Pons, Maria J; Ymana, Barbara; Mayanga-Herrera, Ana; Saenz, Yolanda; Alvarez-Erviti, Lydia; Tapia-Rojas, Salyoc; Gamarra, Roxana; Blanco, Amanda B; Moncunill, Gemma; Ugarte-Gil, Manuel F.
+Institution
+ Pons, Maria J. Grupo Enfermedades Emergentes, Universidad Cientifica del Sur, Lima, Peru.
+ Ymana, Barbara. Grupo Enfermedades Emergentes, Universidad Cientifica del Sur, Lima, Peru.
+ Mayanga-Herrera, Ana. Laboratorio de Cultivo Celular e Inmunologia, Universidad Cientifica del Sur, Lima, Peru.
+ Saenz, Yolanda. Area de Microbiologia Molecular, Centro de Investigacion Biomedica de La Rioja (CIBIR), Logrono, Spain.
+ Alvarez-Erviti, Lydia. Area de Neurobiologia Molecular, Centro de Investigacion Biomedica de La Rioja (CIBIR), Logrono, Spain.
+ Tapia-Rojas, Salyoc. Laboratorio de Cultivo Celular e Inmunologia, Universidad Cientifica del Sur, Lima, Peru.
+ Gamarra, Roxana. Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru.
+ Blanco, Amanda B. Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru.
+ Moncunill, Gemma. ISGlobal, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain.
+ Ugarte-Gil, Manuel F. Grupo Enfermedades Emergentes, Universidad Cientifica del Sur, Lima, Peru.
+ Ugarte-Gil, Manuel F. Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru.
+MeSH Subject Headings
+ *Antibodies, Viral/bl [Blood]
+ Antibodies, Viral/im [Immunology]
+ Biomarkers/bl [Blood]
+ *COVID-19/bl [Blood]
+ COVID-19/im [Immunology]
+ *COVID-19/mo [Mortality]
+ Comorbidity
+ *Cytokines/bl [Blood]
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ Hospitalization
+ Humans
+ Immunoglobulin G/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Peru/ep [Epidemiology]
+ Prognosis
+ SARS-CoV-2/im [Immunology]
+ Severity of Illness Index
+ Spike Glycoprotein, Coronavirus/im [Immunology]
+Keyword Heading
+ COVID-19
+ SARS-CoV-2 IgG
+ biomarkers
+ cytokine
+ prognosis
+ proinflammatory
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cytokines, chemokines and growth factors present different expression profiles related to the prognosis of COVID-19. We analyzed clinical parameters and assessed the expression of these biomarkers in patients with different disease severity in a hospitalized Peruvian cohort to determine those associated with worse prognosis. We measured anti-spike IgG antibodies by ELISA and 30 cytokines by quantitative suspension array technology in 123 sera samples. We analyzed differences between patients with moderate, severe and fatal COVID-19 by logistic regression at baseline and in longitudinal samples. Significant differences were found among the clinical parameters: hemoglobin, neutrophils, lymphocytes and C-reactive protein (CRP), creatinine and D-dimer levels. Higher anti-spike IgG antibody concentrations were associated to fatal patient outcomes. At hospitalization, IL-10, IL-6, MIP-1alpha, GM-CSF, MCP-1, IL-15, IL-5, IL1RA, TNFalpha and IL-8 levels were already increased in fatal patients' group. Meanwhile, multivariable analysis revealed that increased GM-CSF, MCP-1, IL-15, and IL-8 values were associated with fatal outcomes. Moreover, longitudinal analysis identified IL-6 and MCP-1 as the main risk factors related to mortality in hospitalized COVID-19 patients. In this Peruvian cohort we identified and validated biomarkers related to COVID-19 outcomes. Further studies are needed to identify novel criteria for stratification of SARS-CoV-2 infected patients at hospital entry.
+
+ Background: In the most severe forms of SARS-CoV-2 infection, large numbers of innate and adaptive immune cells become activated and begin to produce pro-inflammatory cytokines, establishing an exacerbated feedback loop of inflammation.
+
+ Methods: A total of 55 patients with laboratory-confirmed COVID-19 admitted to the Hospital Nacional Guillermo Almenara Irigoyen in Lima, Peru were enrolled during August-October 2020. Of these, 21 had moderate disease, 24 severe diseases and 10 died. We measured 30 cytokines and chemokines by quantitative suspension array technology and anti-spike IgG antibodies using a commercial ELISA. We evaluated these parameters in peripheral blood every 2-5 days until patient discharge or death. Patient information and clinical parameters related were obtained from the respective clinical histories.
+
+ Results: The frequency of obesity differed among the 3 groups, being most frequent in patients who died. There were also significant differences in clinical parameters: hemoglobin, segmented neutrophils, lymphocytes,C-reactive protein, creatinine and D-dimer levels. Greater anti-spike IgG antibody concentrations were associated to fatal outcomes. In univariate analyses, higher baseline concentrations of IL-6, MIP-1alpha, GM-CSF, MCP-1, IL-15, IL-5, IL1RA, TNFalpha, IL-8 and IL-12p70 correlated with severity, while multivariable analysis showed that increased concentrations in 4 biomarkers (GM-CSF, MCP-1, IL-15, IL-8) were associated with fatal outcomes. Longitudinal analysis showed IL-6 (hazard ratio [HR] 6.81, 95% confidence interval [CI] 1.6-28.7) and MCP-1 (HR 4.61, 95%CI 1.1-19.1) to be related to mortality in hospitalized COVID-19 patients.
+
+ Conclusions: Cytokine, chemokine and growth factor profiles were identified and validated related to severity and outcomes of COVID-19. Our findings may be useful to identify novel criteria for COVID-19 patient stratification at hospital entry. Copyright © 2021 Pons, Ymana, Mayanga-Herrera, Saenz, Alvarez-Erviti, Tapia-Rojas, Gamarra, Blanco, Moncunill and Ugarte-Gil.
+Registry Number/Name of Substance
+ 0 (Antibodies, Viral). 0 (Biomarkers). 0 (Cytokines). 0 (Immunoglobulin G). 0 (Spike Glycoprotein, Coronavirus). 0 (spike protein, SARS-CoV-2).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffimmu.2021.700921
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pons&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Cytokine+Profiles+Associated+With+Worse+Prognosis+in+a+Hospitalized+Peruvian+COVID-19+Cohort.&volume=12&issue=&spage=700921&epage=&date=2021&doi=10.3389%2Ffimmu.2021.700921&pmid=34539631&sid=OVID:medline
+
+<742>
+Unique Identifier
+ 34537741
+Title
+ ASSESSMENT OF ENDOTHELIAL DYSFUNCTION IN PREGNANT WOMEN WITH OBESITY AND PREECLAMPSIA.
+Source
+ Wiadomosci Lekarskie. 74(8):1905-1909, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zelinka-Khobzey MM; Tarasenko KV; Mamontova TV
+Authors Full Name
+ Zelinka-Khobzey, Marta M; Tarasenko, Kostiantyn V; Mamontova, Tetiana V.
+Institution
+ Zelinka-Khobzey, Marta M. POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
+ Tarasenko, Kostiantyn V. POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
+ Mamontova, Tetiana V. POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
+MeSH Subject Headings
+ Biomarkers
+ *Cell-Derived Microparticles
+ Female
+ Humans
+ Obesity/co [Complications]
+ *Pre-Eclampsia
+ Pregnancy
+ Pregnant Women
+Keyword Heading
+ circulating endothelial microparticles CD32+CD40+
+ endothelial dysfunction
+ endothelial vascular growth factor
+ obesity
+ preeclampsia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The aim: To assess the values of endothelial vascular growth factor (VEGF) in blood serum and circulating endothelial microparticles CD32+CD40+ in the peripheral blood of pregnant women depending on the severity of obesity and presence of preeclampsia.
+
+ PATIENTS AND METHODS: Materials and methods: the study included 122 pregnant women divided into groups in accordance with their height and weight parameters and presence of preeclampsia. We studied the serum VEGF concentration by enzyme-linked immunosorbent assay, carried out the count of CD32+CD40+ circulating endothelial microparticles in the peripheral blood by using flow cytometry.
+
+ RESULTS: Results: It has been found out the serum VEGF concentration in pregnant women with obesity decreases with rising level of obesity and the preeclampsia manifestation. In contrast to the decrease in this marker, there is an increase in the number of circulating endothelial microparticles CD32+CD40+ in the peripheral blood of pregnant women with obesity and preeclampsia. This pattern of these indicators points out the presence of endothelial dysfunction, which may contribute to occurrence of preeclampsia in pregnant women with concomitant obesity.
+
+ CONCLUSION: Conclusions: The indicators of VEGF concentration and the count of circulating endothelial microparticles CD32+CD40+ in the blood serum can serve as reliable markers for evaluating the severity of endothelial dysfunction in pregnant women with concomitant obesity and preeclampsia.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&AN=34537741
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zelinka-Khobzey&issn=0043-5147&title=Wiadomosci+Lekarskie&atitle=ASSESSMENT+OF+ENDOTHELIAL+DYSFUNCTION+IN+PREGNANT+WOMEN+WITH+OBESITY+AND+PREECLAMPSIA.&volume=74&issue=8&spage=1905&epage=1909&date=2021&doi=&pmid=34537741&sid=OVID:medline
+
+<743>
+Unique Identifier
+ 34535101
+Title
+ Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: a longitudinal follow-up study.
+Source
+ BMC Endocrine Disorders. 21(1):188, 2021 Sep 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim BY; Choi DH; Jung CH; Mok JO; Kim CH
+Authors Full Name
+ Kim, Bo-Yeon; Choi, Dug-Hyun; Jung, Chan-Hee; Mok, Ji-Oh; Kim, Chul-Hee.
+Institution
+ Kim, Bo-Yeon. Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.
+ Choi, Dug-Hyun. Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.
+ Jung, Chan-Hee. Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.
+ Mok, Ji-Oh. Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.
+ Kim, Chul-Hee. Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea. chkimem@schmc.ac.kr.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ *Body Weight
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Diabetic Nephropathies/ep [Epidemiology]
+ Diabetic Nephropathies/et [Etiology]
+ *Diabetic Nephropathies/pa [Pathology]
+ Female
+ Follow-Up Studies
+ *Glomerular Filtration Rate
+ Humans
+ *Kidney/pp [Physiopathology]
+ Longitudinal Studies
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Republic of Korea/ep [Epidemiology]
+Keyword Heading
+ Body weight changes
+ Decreased renal function
+ Diabetes mellitus
+ Obesity
+ Type 2
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: We aimed to examine the associations between the risk of decreased renal function, obesity, and weight changes in Korean type 2 diabetic patients with normal renal function.
+
+ METHODS: Type 2 diabetic patients (n = 1060) who visited the diabetic clinic at Soonchunhyang University Bucheon Hospital between 2001 and 2007 with follow up surveys completed in 2016 to 2017 were recruited into the study. Decreased renal function was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2. Weight change was calculated between baseline and each follow-up survey. Multivariate analysis was used to evaluate the longitudinal association of baseline obesity and weight changes with the risk of decreased renal function.
+
+ RESULTS: This study revealed that baseline obesity was associated with the risk of decreased renal function after adjusting for clinical variables in type 2 diabetic patients (odds ratio [OR] 1.40; 95% confidence intervals [CI] 1.08-2.04; p = 0.025). Follow-up (mean = 12 years) revealed that weight gain > 10% was associated with the risk of decreased renal function after adjusting for clinical variables in type 2 diabetic patients with normal renal function at baseline (OR 1.43; CI 1.11-2.00; p = 0.016). Weight loss was not associated with the risk of decreased renal function in type 2 diabetic patients with normal renal function at baseline.
+
+ CONCLUSIONS: Baseline obesity was associated with the increased risk of decreased renal function in Korean type 2 diabetic patients with normal renal function. Weight gain > 10% independently predicted the risk of decreased renal function. Large prospective studies are needed to clarify causal associations between obesity, weight change, and decreased renal function in patients with type 2 diabetes. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12902-021-00853-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Associations+between+obesity%2C+weight+change+and+decreased+renal+function+in+Korean+type+2+diabetic+patients%3A+a+longitudinal+follow-up+study.&volume=21&issue=1&spage=188&epage=&date=2021&doi=10.1186%2Fs12902-021-00853-z&pmid=34535101&sid=OVID:medline
+
+<744>
+Unique Identifier
+ 34530819
+Title
+ The association between overweight/obesity and double diabetes in adults with type 1 diabetes; a cross-sectional study.
+Source
+ BMC Endocrine Disorders. 21(1):187, 2021 Sep 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cantley NW; Lonnen K; Kyrou I; Tahrani AA; Kahal H
+Authors Full Name
+ Cantley, Nathan Wp; Lonnen, Kathryn; Kyrou, Ioannis; Tahrani, Abd A; Kahal, Hassan.
+Institution
+ Cantley, Nathan Wp. Department of Clinical Biochemistry, Southmead Hospital, North Bristol NHS Trust, BS10 5NB, Bristol, UK.
+ Lonnen, Kathryn. Department of Diabetes and Endocrinology, Southmead Hospital, North Bristol NHS Trust, BS10 5NB, Bristol, UK.
+ Lonnen, Kathryn. Bristol Weight Management and Bariatric Service, Southmead Hospital, North Bristol NHS Trust, BS10 5NB, Bristol, UK.
+ Kyrou, Ioannis. Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, CV1 5FB, Coventry, UK.
+ Kyrou, Ioannis. Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, CV2 2DX, Coventry, UK.
+ Kyrou, Ioannis. Aston Medical School, College of Health and Life Sciences, Aston Medical Research Institute, Aston University, B4 7ET, Birmingham, UK.
+ Kyrou, Ioannis. Warwick Medical School, University of Warwick, CV4 7AL, Coventry, UK.
+ Tahrani, Abd A. Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
+ Tahrani, Abd A. Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
+ Tahrani, Abd A. Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
+ Kahal, Hassan. Department of Diabetes and Endocrinology, Southmead Hospital, North Bristol NHS Trust, BS10 5NB, Bristol, UK. hassan.kahal1@nhs.net.
+ Kahal, Hassan. Bristol Weight Management and Bariatric Service, Southmead Hospital, North Bristol NHS Trust, BS10 5NB, Bristol, UK. hassan.kahal1@nhs.net.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 1/ep [Epidemiology]
+ *Diabetes Mellitus, Type 1/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prevalence
+ Prognosis
+ United Kingdom/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ Double diabetes
+ Insulin resistance
+ Obesity
+ Overweight
+ Type 1 Diabetes Mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Double Diabetes (DD), type 1 diabetes (T1DM) + insulin resistance (IR), is associated with increased risk of micro/macro-vascular complications and mortality. Obesity can contribute to the development of DD. This study explored the prevalence of overweight/obesity and their association with DD in adults with T1DM.
+
+ METHODS: Cross-sectional study of consecutive adults with T1DM attending diabetes clinics in a secondary care hospital (January-November 2019). Estimated glucose disposal rate (eGDR) was used as a marker of IR, and an eGDR < 8 was used to identify individuals with DD.
+
+ RESULTS: One hundred seven adults with T1DM were included; female/male: 51/56; age [median (inter-quartile range): 30.0 (23-51) years]; BMI 25.4 (22.8-30.0) kg/m2. Overweight/obesity prevalence was 57/107 (53.3 %) [overweight: 30/107 (28 %); obesity: 27/107 (25.2 %)]. Compared to those with normal BMI, individuals with T1DM and overweight/obesity had longer diabetes duration; higher total daily insulin dose; and higher DD prevalence: 48/57 (84.2 %) vs. 14/50 (28 %) (p < 0.01); with similar HbA1c. BMI correlated with total daily insulin dose (rho = 0.55; p < 0.01). Individuals with DD were older, had longer duration of diabetes, higher HbA1c, and more adverse lipid profile and microalbuminuria compared to those without DD.
+
+ CONCLUSIONS: Overweight/obesity is very common in adults with T1DM, and is associated with double diabetes. BMI is positively associated with total insulin dose. Double diabetes is associated with adverse cardiovascular risk profile and is also common in lean individuals with T1DM. Further research is needed to examine the impact of overweight/obesity in people with T1DM and whether weight loss in this population can improve diabetes-related outcomes. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12902-021-00851-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cantley&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=The+association+between+overweight%2Fobesity+and+double+diabetes+in+adults+with+type+1+diabetes%3B+a+cross-sectional+study.&volume=21&issue=1&spage=187&epage=&date=2021&doi=10.1186%2Fs12902-021-00851-1&pmid=34530819&sid=OVID:medline
+
+<745>
+Unique Identifier
+ 34526523
+Title
+ Use of human PBMC to analyse the impact of obesity on lipid metabolism and metabolic status: a proof-of-concept pilot study.
+Source
+ Scientific Reports. 11(1):18329, 2021 09 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Costa A; Reynes B; Konieczna J; Martin M; Fiol M; Palou A; Romaguera D; Oliver P
+Authors Full Name
+ Costa, Andrea; Reynes, Barbara; Konieczna, Jadwiga; Martin, Marian; Fiol, Miquel; Palou, Andreu; Romaguera, Dora; Oliver, Paula.
+Institution
+ Costa, Andrea. Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) Group, University of the Balearic Islands (UIB), Palma, Spain.
+ Costa, Andrea. Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
+ Costa, Andrea. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
+ Reynes, Barbara. Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) Group, University of the Balearic Islands (UIB), Palma, Spain.
+ Reynes, Barbara. Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
+ Reynes, Barbara. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
+ Konieczna, Jadwiga. Research Group on Nutritional Epidemiology and Cardiovascular Physiopathology (NUTRECOR), University Hospital Son Espases (HUSE), Palma, Spain.
+ Konieczna, Jadwiga. Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
+ Konieczna, Jadwiga. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
+ Martin, Marian. Research Group on Nutritional Epidemiology and Cardiovascular Physiopathology (NUTRECOR), University Hospital Son Espases (HUSE), Palma, Spain.
+ Martin, Marian. Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
+ Martin, Marian. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
+ Fiol, Miquel. Research Group on Nutritional Epidemiology and Cardiovascular Physiopathology (NUTRECOR), University Hospital Son Espases (HUSE), Palma, Spain.
+ Fiol, Miquel. Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
+ Fiol, Miquel. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
+ Palou, Andreu. Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) Group, University of the Balearic Islands (UIB), Palma, Spain. andreu.palou@uib.es.
+ Palou, Andreu. Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain. andreu.palou@uib.es.
+ Palou, Andreu. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain. andreu.palou@uib.es.
+ Romaguera, Dora. Research Group on Nutritional Epidemiology and Cardiovascular Physiopathology (NUTRECOR), University Hospital Son Espases (HUSE), Palma, Spain.
+ Romaguera, Dora. Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
+ Romaguera, Dora. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
+ Oliver, Paula. Nutrigenomics, Biomarkers and Risk Evaluation (NuBE) Group, University of the Balearic Islands (UIB), Palma, Spain.
+ Oliver, Paula. Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
+ Oliver, Paula. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ *Biomarkers
+ Body Composition
+ Body Weights and Measures
+ Disease Susceptibility
+ Female
+ Humans
+ *Leukocytes, Mononuclear/me [Metabolism]
+ *Lipid Metabolism
+ Male
+ Middle Aged
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Overweight/et [Etiology]
+ Overweight/me [Metabolism]
+ Pilot Projects
+ Principal Component Analysis
+ Young Adult
+Abstract
+ Peripheral blood mononuclear cells (PBMC) are widely used as a biomarker source in nutrition/obesity studies because they reflect gene expression profiles of internal tissues. In this pilot proof-of-concept study we analysed in humans if, as we previously suggested in rodents, PBMC could be a surrogate tissue to study overweight/obesity impact on lipid metabolism. Pre-selected key lipid metabolism genes based in our previous preclinical studies were analysed in PBMC of normoglycemic normal-weight (NW), and overweight-obese (OW-OB) subjects before and after a 6-month weight-loss plan. PBMC mRNA levels of CPT1A, FASN and SREBP-1c increased in the OW-OB group, according with what described in liver and adipose tissue of humans with obesity. This altered expression pattern was related to increased adiposity and early signs of metabolic impairment. Greater weight loss and/or metabolic improvement as result of the intervention was related to lower CPT1A, FASN and SREBP-1c gene expression in an adjusted linear mixed-effects regression analysis, although no gene expression recovery was observed when considering mean comparisons. Thus, human PBMC reflect lipid metabolism expression profile of energy homeostatic tissues, and early obesity-related alterations in metabolic at-risk subjects. Further studies are needed to understand PBMC usefulness for analysis of metabolic recovery in weigh management programs. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-96981-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Costa&issn=2045-2322&title=Scientific+Reports&atitle=Use+of+human+PBMC+to+analyse+the+impact+of+obesity+on+lipid+metabolism+and+metabolic+status%3A+a+proof-of-concept+pilot+study.&volume=11&issue=1&spage=18329&epage=&date=2021&doi=10.1038%2Fs41598-021-96981-6&pmid=34526523&sid=OVID:medline
+
+<746>
+Unique Identifier
+ 34525937
+Title
+ A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents.
+Source
+ Molecular Medicine. 27(1):108, 2021 09 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moran-Ramos S; Macias-Kauffer L; Lopez-Contreras BE; Villamil-Ramirez H; Ocampo-Medina E; Leon-Mimila P; Del Rio-Navarro BE; Granados-Portillo O; Ibarra-Gonzalez I; Vela-Amieva M; Tovar AR; Torres N; Gomez-Perez FJ; Aguilar-Salinas C; Canizales-Quinteros S
+Author NameID
+ Moran-Ramos, Sofia; ORCID: https://orcid.org/0000-0003-0421-1166
+Authors Full Name
+ Moran-Ramos, Sofia; Macias-Kauffer, Luis; Lopez-Contreras, Blanca E; Villamil-Ramirez, Hugo; Ocampo-Medina, Elvira; Leon-Mimila, Paola; Del Rio-Navarro, Blanca E; Granados-Portillo, Omar; Ibarra-Gonzalez, Isabel; Vela-Amieva, Marcela; Tovar, Armando R; Torres, Nimbe; Gomez-Perez, Francisco J; Aguilar-Salinas, Carlos; Canizales-Quinteros, Samuel.
+Institution
+ Moran-Ramos, Sofia. Consejo Nacional de Ciencia y Tecnologia (CONACYT), Mexico City, Mexico. smoran@inmegen.gob.mx.
+ Moran-Ramos, Sofia. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/Instituto Nacional de Medicina Genomica (INMEGEN), Periferico Sur No. 4809, Tlalpan, 14610, Mexico City, Mexico. smoran@inmegen.gob.mx.
+ Macias-Kauffer, Luis. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/Instituto Nacional de Medicina Genomica (INMEGEN), Periferico Sur No. 4809, Tlalpan, 14610, Mexico City, Mexico.
+ Lopez-Contreras, Blanca E. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/Instituto Nacional de Medicina Genomica (INMEGEN), Periferico Sur No. 4809, Tlalpan, 14610, Mexico City, Mexico.
+ Villamil-Ramirez, Hugo. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/Instituto Nacional de Medicina Genomica (INMEGEN), Periferico Sur No. 4809, Tlalpan, 14610, Mexico City, Mexico.
+ Ocampo-Medina, Elvira. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/Instituto Nacional de Medicina Genomica (INMEGEN), Periferico Sur No. 4809, Tlalpan, 14610, Mexico City, Mexico.
+ Leon-Mimila, Paola. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/Instituto Nacional de Medicina Genomica (INMEGEN), Periferico Sur No. 4809, Tlalpan, 14610, Mexico City, Mexico.
+ Del Rio-Navarro, Blanca E. Hospital Infantil Mexico Federico Gomez, Mexico City, Mexico.
+ Granados-Portillo, Omar. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Ibarra-Gonzalez, Isabel. Instituto de Investigaciones Biomedicas, UNAM - Instituto Nacional de Pediatria, Mexico City, Mexico.
+ Vela-Amieva, Marcela. Laboratorio de Errores Innatos del Metabolismo y Tamiz, Instituto Nacional de Pediatria, Mexico City, Mexico.
+ Tovar, Armando R. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Torres, Nimbe. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Gomez-Perez, Francisco J. Departamento de Endocrinologia y Metabolismo, Instituto Nacional de Ciencias Medicas Y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Aguilar-Salinas, Carlos. Unidad de Investigacion en Enfermedades Metabolicas and Departamento de Endocrinologia y Metabolismo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Aguilar-Salinas, Carlos. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, 64710, Monterrey, NL, Mexico.
+ Canizales-Quinteros, Samuel. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/Instituto Nacional de Medicina Genomica (INMEGEN), Periferico Sur No. 4809, Tlalpan, 14610, Mexico City, Mexico.
+MeSH Subject Headings
+ Adolescent
+ Age Factors
+ *Amino Acids, Branched-Chain/bl [Blood]
+ Amino Acids, Branched-Chain/me [Metabolism]
+ Biomarkers
+ Body Weights and Measures
+ Child
+ *Faecalibacterium prausnitzii/ph [Physiology]
+ Female
+ *Gastrointestinal Microbiome
+ Humans
+ Insulin Resistance
+ Male
+ Metabolomics/mt [Methods]
+ Metagenome
+ Metagenomics/mt [Methods]
+ Obesity/me [Metabolism]
+ Public Health Surveillance
+Keyword Heading
+ BCAA
+ Children
+ Faecalibacterium prausnitzii
+ Gut microbiome
+ Insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Elevations of circulating branched-chain amino acids (BCAA) are observed in humans with obesity and metabolic comorbidities, such as insulin resistance. Although it has been described that microbial metabolism contributes to the circulating pool of these amino acids, studies are still scarce, particularly in pediatric populations. Thus, we aimed to explore whether in early adolescents, gut microbiome was associated to circulating BCAA and in this way to insulin resistance.
+
+ METHODS: Shotgun sequencing was performed in DNA from fecal samples of 23 early adolescents (10-12 years old) and amino acid targeted metabolomics analysis was performed by LC-MS/MS in serum samples. By using the HUMAnN2 algorithm we explored microbiome functional profiles to identify whether bacterial metabolism contributed to serum BCAA levels and insulin resistance markers.
+
+ RESULTS: We identified that abundance of genes encoding bacterial BCAA inward transporters were negatively correlated with circulating BCAA and HOMA-IR (P < 0.01). Interestingly, Faecalibacterium prausnitzii contributed to approximately ~ 70% of bacterial BCAA transporters gene count. Moreover, Faecalibacterium prausnitzii abundance was also negatively correlated with circulating BCAA (P = 0.001) and with HOMA-IR (P = 0.018), after adjusting for age, sex and body adiposity. Finally, the association between Faecalibacterium genus and BCAA levels was replicated over an extended data set (N = 124).
+
+ CONCLUSIONS: We provide evidence that gut bacterial BCAA transport genes, mainly encoded by Faecalibacterium prausnitzii, are associated with lower circulating BCAA and lower insulin resistance. Based on the later, we propose that the relationship between Faecalibacterium prausnitzii and insulin resistance, could be through modulation of BCAA. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs10020-021-00371-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moran-Ramos&issn=1076-1551&title=Molecular+Medicine&atitle=A+higher+bacterial+inward+BCAA+transport+driven+by+Faecalibacterium+prausnitzii+is+associated+with+lower+serum+levels+of+BCAA+in+early+adolescents.&volume=27&issue=1&spage=108&epage=&date=2021&doi=10.1186%2Fs10020-021-00371-7&pmid=34525937&sid=OVID:medline
+
+<747>
+Unique Identifier
+ 34520137
+Title
+ COVID and venous thrombosis: systematic review of literature.
+Source
+ Journal of Cardiovascular Surgery. 62(6):548-557, 2021 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mazzaccaro D; Giannetta M; Fancoli F; Milani V; Modafferi A; Malacrida G; Righini P; Marrocco-Trischitta MM; Nano G
+Authors Full Name
+ Mazzaccaro, Daniela; Giannetta, Matteo; Fancoli, Fabiana; Milani, Valentina; Modafferi, Alfredo; Malacrida, Giovanni; Righini, Paolo; Marrocco-Trischitta, Massimiliano M; Nano, Giovanni.
+Institution
+ Mazzaccaro, Daniela. Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy - daniela.mazzaccaro@gmail.com.
+ Giannetta, Matteo. Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Fancoli, Fabiana. Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Milani, Valentina. Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Modafferi, Alfredo. Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Malacrida, Giovanni. Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Righini, Paolo. Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Marrocco-Trischitta, Massimiliano M. Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Nano, Giovanni. Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Nano, Giovanni. Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
+MeSH Subject Headings
+ Age Factors
+ Anticoagulants/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ Blood Coagulation/de [Drug Effects]
+ *Blood Coagulation
+ COVID-19/bl [Blood]
+ COVID-19/di [Diagnosis]
+ *COVID-19/ep [Epidemiology]
+ COVID-19/th [Therapy]
+ Fibrin Fibrinogen Degradation Products/me [Metabolism]
+ Hospitalization
+ Humans
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ Venous Thrombosis/bl [Blood]
+ Venous Thrombosis/di [Diagnosis]
+ Venous Thrombosis/dt [Drug Therapy]
+ *Venous Thrombosis/ep [Epidemiology]
+Abstract
+ INTRODUCTION: We aimed to review the prevalence, the risk factors and the outcomes of venous thrombosis (VT) in patients hospitalized for COronaVirus Disease 19 (COVID-19).
+
+ EVIDENCE ACQUISITION: Electronic bibliographic databases were searched using the words "COVID venous thrombosis". The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards.
+
+ EVIDENCE SYNTHESIS: The search of the literature retrieved 877 results. After assessment of full texts, 69 papers were included in the qualitative analysis and 23 of them in the quantitative evaluation. The analyzed studies included a total of 106,838 patients hospitalized for COVID-19 from January to December 2020. The pooled reported prevalence rate of VT was in median 16.7% (IQR 5.8-30%), being higher in ICU patients (60.8-85.4%). VT events were reported in about 75% of cases in the popliteal and calf veins. Signs and symptoms were present in 6.1% of cases. At quantitative evaluation, older age, D-dimer and obesity increased the odds to experience a VT (OR=3.54, 95% CI 0.65-6.43, P=0.01; OR=956.86, 95% CI 225.67-1668.05, P=0.01; OR=1.42, 95% CI 1.01-1.99, P=0.03 respectively). Female sex seemed to be protective against the odds of VT (OR=0.77, 95% CI 0.63-0.93, P=0.007).
+
+ CONCLUSIONS: Among patients hospitalized for COVID-19, VT is a relatively common finding, with higher prevalence rates in ICU patients. VT occurs mostly in the distal regions of the lower limb and is asymptomatic in most cases. Older age, obesity and higher D-dimer values on admission increased the odds of VT, while female sex was protective against the odds of VT.
+Registry Number/Name of Substance
+ 0 (Anticoagulants). 0 (Biomarkers). 0 (Fibrin Fibrinogen Degradation Products). 0 (fibrin fragment D).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.23736%2fS0021-9509.21.12022-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mazzaccaro&issn=0021-9509&title=Journal+of+Cardiovascular+Surgery&atitle=COVID+and+venous+thrombosis%3A+systematic+review+of+literature.&volume=62&issue=6&spage=548&epage=557&date=2021&doi=10.23736%2FS0021-9509.21.12022-1&pmid=34520137&sid=OVID:medline
+
+<748>
+Unique Identifier
+ 34518612
+Title
+ The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis.
+Source
+ Scientific Reports. 11(1):18100, 2021 09 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang Y; Cai Z; Zhang J
+Authors Full Name
+ Yang, Yan; Cai, Zixin; Zhang, Jingjing.
+Institution
+ Yang, Yan. National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
+ Cai, Zixin. National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
+ Zhang, Jingjing. National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. doctorzhangjj@csu.edu.cn.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Female
+ Humans
+ Micronutrients/df [Deficiency]
+ Micronutrients/me [Metabolism]
+ *Micronutrients
+ *Nutritional Status
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Odds Ratio
+ Overweight/et [Etiology]
+ Overweight/me [Metabolism]
+ Pregnancy
+ Pregnancy Complications/et [Etiology]
+ Pregnancy Complications/me [Metabolism]
+ Publication Bias
+Abstract
+ The relationship between prepregnancy body mass index (BMI) and maternal micronutrient status is inconsistent and has not received sufficient attention. This meta-analysis aimed to evaluate the effect of prepregnancy BMI on micronutrient levels in pregnant women. PubMed, Embase, Web of Science, and the Cochrane Library were searched for articles that contained information on micronutrient levels and prepregnancy BMI. A random-effects model was used to determine the association between prepregnancy BMI and maternal micronutrient status. Sixty-one eligible articles were eventually included, with 83,554 participants. Vitamin B12, folate, vitamin D, iron and ferritin were the main micronutrients evaluated in our meta-analysis. Prepregnancy obesity and overweight may lead to an increased risk of micronutrient deficiency, including vitamin B12, folate and vitamin D deficiency, while prepregnancy obesity or overweight may have no significant association with ferritin deficiency. Additionally, the results of the dose-response analyses demonstrated a possible significant inverse correlation between prepregnancy BMI and levels of micronutrient, except for iron and ferritin. Compared with women with normal weight, women who were overweight or obese prepregnancy have lower micronutrient concentrations and are more likely to exhibit micronutrient deficiency during pregnancy, which is harmful to both mothers and neonates. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Micronutrients).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-97635-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=2045-2322&title=Scientific+Reports&atitle=The+effect+of+prepregnancy+body+mass+index+on+maternal+micronutrient+status%3A+a+meta-analysis.&volume=11&issue=1&spage=18100&epage=&date=2021&doi=10.1038%2Fs41598-021-97635-3&pmid=34518612&sid=OVID:medline
+
+<749>
+Unique Identifier
+ 34518090
+Title
+ Serum uric acid is associated with incident metabolic syndrome independent of body shape index and body roundness index in healthy individuals.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(11):3142-3151, 2021 10 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tu CM; Wei TE; Tseng GS; Chen CC; Liu CW
+Authors Full Name
+ Tu, Chung-Ming; Wei, Ting-En; Tseng, Guo-Shiang; Chen, Chien-Chou; Liu, Cheng-Wei.
+Institution
+ Tu, Chung-Ming. Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Chihlee Institute of Technology, New Taipei City, Taiwan.
+ Wei, Ting-En. Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei, Taiwan; Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
+ Tseng, Guo-Shiang. Division of Cardiology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan County, Taiwan.
+ Chen, Chien-Chou. Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei, Taiwan.
+ Liu, Cheng-Wei. Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: issac700319@gmail.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Female
+ Humans
+ Hyperuricemia/bl [Blood]
+ Hyperuricemia/di [Diagnosis]
+ *Hyperuricemia/ep [Epidemiology]
+ Incidence
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ Taiwan/ep [Epidemiology]
+ *Uric Acid/bl [Blood]
+Keyword Heading
+ Body roundness index
+ Body shape index
+ Hyperuricemia
+ Metabolic syndrome
+ Uric acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Elevated serum uric acid (SUA) levels, body shape index (BSI) and body roundness index (BRI) were associated with incident metabolic syndrome (MetS). We aimed to investigate the relationship among the SUA level, BSI, and BRI on the incidence of MetS.
+
+ METHODS AND RESULTS: We retrospectively included 6221 healthy individuals from annual health exams at our hospital between 2016/1/1 and 2016/12/31. We defined hyperuricemia as SUA levels greater than 7 mg/dl in men and 6 mg/dl in women and MetS according to the contemporary definition. The study cohort included 6221 healthy individuals with an overall incidence rate of MetS of 9.8%. Compared with the normouricemic group, the hyperuricemic group had a greater incidence of MetS (17.2% vs. 9.6%, P < 0.001). After full adjustment for confounders, the SUA level was significantly associated with incident MetS in addition to body mass index (BMI) (adjusted OR [aOR]: 1.161, 95% CI: 1.071-1.259, P < 0.001), BRI (aOR: 1.196, 95% CI: 1.104-1.296, P < 0.001), and BSI (aOR: 1.297, 95% CI: 1.200-1.403, P < 0.001). Regarding the anthropometric indices, BMI and BRI were independent predictors of incident MetS, but the BSI lost its significant association in multivariate logistic regression analyses. In sensitivity analyses, various thresholds of elevated SUA levels remained associated with incident MetS.
+
+ CONCLUSION: We showed a dose-response effect of SUA on incident MetS independent of BMI, BRI and BSI in healthy individuals. Future studies can use SUA levels to stratify cardiometabolic risk in healthy individuals.
+
+ CLINICAL TRIALS: ClinicalTrials.gov with the identification number NCT03473951. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.07.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tu&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Serum+uric+acid+is+associated+with+incident+metabolic+syndrome+independent+of+body+shape+index+and+body+roundness+index+in+healthy+individuals.&volume=31&issue=11&spage=3142&epage=3151&date=2021&doi=10.1016%2Fj.numecd.2021.07.008&pmid=34518090&sid=OVID:medline
+
+<750>
+Unique Identifier
+ 34518089
+Title
+ Changes in adiposity mediate the associations of diet quality with insulin sensitivity and beta-cell function.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(11):3054-3063, 2021 10 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lai KZH; Semnani-Azad Z; Retnakaran R; Harris SB; Hanley AJ
+Authors Full Name
+ Lai, Kira Zhi Hua; Semnani-Azad, Zhila; Retnakaran, Ravi; Harris, Stewart B; Hanley, Anthony J.
+Institution
+ Lai, Kira Zhi Hua. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address: kira.lai@mail.utoronto.ca.
+ Semnani-Azad, Zhila. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address: z.semnani.azad@mail.utoronto.ca.
+ Retnakaran, Ravi. Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Electronic address: Ravi.Retnakaran@sinaihealth.ca.
+ Harris, Stewart B. Department of Family Medicine, Western University, London, Canada. Electronic address: stewart.harris@schulich.uwo.ca.
+ Hanley, Anthony J. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada; Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada. Electronic address: anthony.hanley@utoronto.ca.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diet/ae [Adverse Effects]
+ Female
+ Humans
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ *Insulin-Secreting Cells/me [Metabolism]
+ Longitudinal Studies
+ Male
+ Middle Aged
+ *Nutritive Value
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ Ontario/ep [Epidemiology]
+ Prognosis
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Time Factors
+ Waist Circumference
+Keyword Heading
+ Alternate Healthy Eating Index
+ Beta-cell function
+ Insulin resistance
+ Insulin sensitivity
+ Mediation
+ Obesity
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: To examine the mediating role of adiposity on the associations of diet quality with longitudinal changes in insulin sensitivity and beta-cell function.
+
+ METHODS AND RESULTS: Adults at-risk for type 2 diabetes (T2D) in the PROMISE cohort had 4 assessments over 9 years (n = 442). Alternate Healthy Eating Index (AHEI) scores were used to assess diet quality. Generalized Estimating Equations (GEE) evaluated the associations between the AHEI and longitudinal changes in insulin sensitivity (HOMA2-%S and ISI) and beta-cell function (IGI/HOMA-IR and ISSI-2). The proportion of the mediating effect of waist circumference changes was estimated using the difference method. In the primary longitudinal analysis, AHEI was positively associated with insulin sensitivity and beta-cell function over time (% difference per standard deviation increase of AHEI for HOMA2-%S (beta = 11.0, 95%CI 5.43-17.0), ISI (beta = 10.4, 95%CI 4.35-16.8), IGI/HOMA-IR (beta = 7.12, 95%CI 0.98-13.6) and ISSI-2 (beta = 4.38, 95%CI 1.05-7.80), all p < 0.05). There was no significant association between AHEI and dysglycemia incidence (OR = 0.95, 95%CI 0.77-1.17). Adjustments for longitudinal changes in waist circumference substantially attenuated all associations of AHEI with insulin sensitivity and beta-cell function. Mediation analysis indicated that waist circumference mediated 73%, 70%, 83% and 81% of the association between AHEI and HOMA2-%S, ISI, IGI/HOMA-IR, and ISSI-2, respectively (all p < 0.01).
+
+ CONCLUSION: In a Canadian population at-risk for T2D, AHEI score was positively associated with changes in insulin sensitivity and beta-cell function. These associations were substantially mediated by waist circumference, suggesting that changes in adiposity may represent an important pathway linking diet quality with risk phenotypes for T2D. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.07.025
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lai&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Changes+in+adiposity+mediate+the+associations+of+diet+quality+with+insulin+sensitivity+and+beta-cell+function.&volume=31&issue=11&spage=3054&epage=3063&date=2021&doi=10.1016%2Fj.numecd.2021.07.025&pmid=34518089&sid=OVID:medline
+
+<751>
+Unique Identifier
+ 34518084
+Title
+ Positive association between body fat percentage and hyperuricemia in patients with hypertension: The China H-type hypertension registry study.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(11):3076-3084, 2021 10 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xiong Y; Wangsheng F; Wang S; Zhou W; Huang X; Bao H; Cheng X
+Authors Full Name
+ Xiong, Yurong; Wangsheng, Fang; Wang, Shizhi; Zhou, Wei; Huang, Xiao; Bao, Huihui; Cheng, Xiaoshu.
+Institution
+ Xiong, Yurong. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China; Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang of Jiangxi, China.
+ Wangsheng, Fang. Wuyuan Health Committee, Shangrao of Jiangxi, China.
+ Wang, Shizhi. The Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, China.
+ Zhou, Wei. Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China; Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang of Jiangxi, China.
+ Huang, Xiao. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China; Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China; Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang of Jiangxi, China.
+ Bao, Huihui. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China; Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China; Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang of Jiangxi, China. Electronic address: huihui_bao77@126.com.
+ Cheng, Xiaoshu. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China; Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China; Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang of Jiangxi, China. Electronic address: xiaoshumenfan126@163.com.
+MeSH Subject Headings
+ *Adiposity
+ Biomarkers/bl [Blood]
+ *Blood Pressure
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Hypertension/di [Diagnosis]
+ *Hypertension/ep [Epidemiology]
+ Hypertension/pp [Physiopathology]
+ Hyperuricemia/bl [Blood]
+ Hyperuricemia/di [Diagnosis]
+ *Hyperuricemia/ep [Epidemiology]
+ Male
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ Registries
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ *Uric Acid/bl [Blood]
+Keyword Heading
+ Body fat percentage
+ Hypertension
+ Hyperuricemia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: The relationship between the body fat percentage (BFP) and hyperuricemia is still unknown in different gender subjects. The purpose of this study was to determine the magnitude of the association between the BFP and the presence of hyperuricemia in the sex-specific group among hypertensive patients.
+
+ METHODS AND RESULTS: We conducted a cross-sectional study enrolling 14,234 hypertensive participates from the Chinese Hypertension Registry Study. Body fat percentage (BFP) was calculated by simple anthropometric parameters. Hyperuricemia was defined as serum uric acid (SUA) level 420 umol/L in men and 360 umol/L in women. The mean BFP was 24.5% in men and 37.1% in women. Multiple logistic analyses showed that the relationship between BFP with the risk of hyperuricemia in a dose-dependent manner among both men (odds ratio [OR] 1.07, 95% CI 1.06, 1.09) and women (OR 1.08, 95% CI 1.06, 1.09) in the fully adjusted model. Subgroup analyses showed the positive association between BFP and the risk of hyperuricemia was consistent in all stratification subgroups (all P for interaction >0.05).
+
+ CONCLUSION: For patients with hypertension, BFP was positively associated with an increased risk of hyperuricemia among both men and women. Copyright © 2021. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article. Multicenter Study. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.07.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xiong&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Positive+association+between+body+fat+percentage+and+hyperuricemia+in+patients+with+hypertension%3A+The+China+H-type+hypertension+registry+study.&volume=31&issue=11&spage=3076&epage=3084&date=2021&doi=10.1016%2Fj.numecd.2021.07.002&pmid=34518084&sid=OVID:medline
+
+<752>
+Unique Identifier
+ 34508150
+Title
+ Obesity, not a high fat, high sucrose diet alone, induced glucose intolerance and cardiac dysfunction during pregnancy and postpartum.
+Source
+ Scientific Reports. 11(1):18057, 2021 09 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chung E; Gonzalez K; Ullevig SL; Zhang J; Umeda M
+Authors Full Name
+ Chung, Eunhee; Gonzalez, Kassandra; Ullevig, Sarah L; Zhang, John; Umeda, Masataka.
+Institution
+ Chung, Eunhee. Department of Kinesiology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA. eunhee.chung@utsa.edu.
+ Gonzalez, Kassandra. Department of Kinesiology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
+ Ullevig, Sarah L. College for Health, Community and Policy, University of Texas at San Antonio, San Antonio, TX, USA.
+ Zhang, John. Department of Kinesiology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
+ Umeda, Masataka. Department of Kinesiology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
+MeSH Subject Headings
+ Biomarkers
+ Blood Glucose
+ Diet, High-Fat/ae [Adverse Effects]
+ Dietary Sucrose/ae [Adverse Effects]
+ Disease Susceptibility
+ Female
+ Glucose Intolerance/et [Etiology]
+ *Glucose Intolerance/me [Metabolism]
+ Heart Diseases/di [Diagnosis]
+ *Heart Diseases/et [Etiology]
+ *Heart Diseases/me [Metabolism]
+ Heart Diseases/pp [Physiopathology]
+ Heart Function Tests
+ Humans
+ Insulin Resistance
+ Lipids/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Postpartum Period
+ Pregnancy
+ *Pregnancy Complications, Cardiovascular/et [Etiology]
+ *Pregnancy Complications, Cardiovascular/me [Metabolism]
+ Pregnancy Complications, Cardiovascular/pp [Physiopathology]
+Abstract
+ Cardiovascular disease is the leading cause of death in women during pregnancy and the postpartum period. Obesity is an independent risk factor for cardiovascular diseases. Nearly 60% of women of reproductive age are considered overweight or obese, cardiovascular disease morbidity and mortality continue to be pervasive. The objective of this study was to determine the effects of an obesogenic diet on the cardiometabolic health of dams during pregnancy and postpartum. Female mice were fed either a high-fat, high-sucrose diet (HFHS) or a refined control diet (CON) for 8 weeks before initiation of pregnancy and throughout the study period. Mice in the HFHS showed two distinct phenotypes, obesity-prone (HFHS/OP) and obesity resistance (HFHS/OR). Pre-pregnancy obesity (HFHS/OP) induced glucose intolerance before pregnancy and during postpartum. Systolic function indicated by the percent fractional shortening (%FS) was significantly decreased in the HFHS/OP at late pregnancy (vs. HFHS/OR) and weaning (vs. CON), but no differences were found at 6 weeks of postpartum among groups. No induction of pathological cardiac hypertrophy markers was found during postpartum. Plasma adiponectin was decreased while total cholesterol was increased in the HFHS/OP. Our results suggested that obesity, not the diet alone, negatively affected cardiac adaptation during pregnancy and postpartum. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Sucrose). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-97336-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chung&issn=2045-2322&title=Scientific+Reports&atitle=Obesity%2C+not+a+high+fat%2C+high+sucrose+diet+alone%2C+induced+glucose+intolerance+and+cardiac+dysfunction+during+pregnancy+and+postpartum.&volume=11&issue=1&spage=18057&epage=&date=2021&doi=10.1038%2Fs41598-021-97336-x&pmid=34508150&sid=OVID:medline
+
+<753>
+Unique Identifier
+ 34507573
+Title
+ The BAriatic surgery SUbstitution and nutrition (BASUN) population: a data-driven exploration of predictors for obesity.
+Source
+ BMC Endocrine Disorders. 21(1):183, 2021 Sep 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hoskuldsdottir G; Engstrom M; Rawshani A; Wallenius V; Lener F; Fandriks L; Mossberg K; Eliasson B
+Authors Full Name
+ Hoskuldsdottir, Gudrun; Engstrom, My; Rawshani, Araz; Wallenius, Ville; Lener, Frida; Fandriks, Lars; Mossberg, Karin; Eliasson, Bjorn.
+Institution
+ Hoskuldsdottir, Gudrun. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. gudrun.hoskuldsdottir@gu.se.
+ Hoskuldsdottir, Gudrun. Department of Medicine, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden. gudrun.hoskuldsdottir@gu.se.
+ Engstrom, My. Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Engstrom, My. Department of Surgery, Region Vastra Gotaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
+ Rawshani, Araz. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Wallenius, Ville. Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.
+ Wallenius, Ville. Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
+ Lener, Frida. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Lener, Frida. Department of Public Health and Community Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
+ Fandriks, Lars. Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.
+ Fandriks, Lars. Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
+ Mossberg, Karin. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Mossberg, Karin. Department of Public Health and Community Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
+ Eliasson, Bjorn. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Eliasson, Bjorn. Department of Medicine, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden.
+MeSH Subject Headings
+ Adult
+ *Bariatric Surgery/mt [Methods]
+ *Biomarkers/an [Analysis]
+ *Body Mass Index
+ *Exercise
+ Female
+ Follow-Up Studies
+ Gastrectomy/mt [Methods]
+ Gastric Bypass/mt [Methods]
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ *Life Style
+ Male
+ Middle Aged
+ Non-Randomized Controlled Trials as Topic
+ Nutritional Status
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/su [Surgery]
+ Prognosis
+ Prospective Studies
+ *Quality of Life
+ Sweden/ep [Epidemiology]
+Keyword Heading
+ Bariatric surgery
+ Cohort study
+ Diet
+ Obesity
+ Prospective study
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The development of obesity is most likely due to a combination of biological and environmental factors some of which might still be unidentified. We used a machine learning technique to examine the relative importance of more than 100 clinical variables as predictors for BMI.
+
+ METHODS: BASUN is a prospective non-randomized cohort study of 971 individuals that received medical or surgical treatment (treatment choice was based on patient's preferences and clinical criteria, not randomization) for obesity in the Vastra Gotaland county in Sweden between 2015 and 2017 with planned follow-up for 10 years. This study includes demographic data, BMI, blood tests, and questionnaires before obesity treatment that cover three main areas: gastrointestinal symptoms and eating habits, physical activity and quality of life, and psychological health. We used random forest, with conditional variable importance, to study the relative importance of roughly 100 predictors of BMI, covering 15 domains. We quantified the predictive value of each individual predictor, as well as each domain.
+
+ RESULTS: The participants received medical (n = 382) or surgical treatment for obesity (Roux-en-Y gastric bypass, n = 388; sleeve gastrectomy, n = 201). There were minor differences between these groups before treatment with regard to anthropometrics, laboratory measures and results from questionnaires. The 10 individual variables with the strongest predictive value, in order of decreasing strength, were country of birth, marital status, sex, calcium levels, age, levels of TSH and HbA1c, AUDIT score, BE tendencies according to QEWPR, and TG levels. The strongest domains predicting BMI were: Socioeconomic status, Demographics, Biomarkers (notably TSH), Lifestyle/habits, Biomarkers for cardiovascular disease and diabetes, and Potential anxiety and depression.
+
+ CONCLUSIONS: Lifestyle, habits, age, sex and socioeconomic status are some of the strongest predictors for BMI levels. Potential anxiety and / or depression and other characteristics captured using questionnaires have strong predictive value. These results confirm previously suggested associations and advocate prospective studies to examine the value of better characterization of patients eligible for obesity treatment, and consequently to evaluate the treatment effects in groups of patients.
+
+ TRIAL REGISTRATION: March 03, 2015; NCT03152617 . Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12902-021-00849-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hoskuldsdottir&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=The+BAriatic+surgery+SUbstitution+and+nutrition+%28BASUN%29+population%3A+a+data-driven+exploration+of+predictors+for+obesity.&volume=21&issue=1&spage=183&epage=&date=2021&doi=10.1186%2Fs12902-021-00849-9&pmid=34507573&sid=OVID:medline
+
+<754>
+Unique Identifier
+ 34502470
+Title
+ The Importance of Food for Endotoxemia and an Inflammatory Response. [Review]
+Source
+ International Journal of Molecular Sciences. 22(17), 2021 Sep 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Erlanson-Albertsson C; Stenkula KG
+Author NameID
+ Stenkula, Karin G; ORCID: https://orcid.org/0000-0002-0739-1150
+Authors Full Name
+ Erlanson-Albertsson, Charlotte; Stenkula, Karin G.
+Institution
+ Erlanson-Albertsson, Charlotte. Appetite Control, Department of Experimental Medical Science, BMC, Lund University, 221 84 Lund, Sweden.
+ Stenkula, Karin G. Glucose Transport and Protein Trafficking, Department of Experimental Medical Science, BMC, Lund University, 221 84 Lund, Sweden.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Dietary Fats
+ *Endotoxemia/bl [Blood]
+ Endotoxemia/et [Etiology]
+ *Food Contamination
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/et [Etiology]
+ *Lipopolysaccharides/to [Toxicity]
+ *Obesity/bl [Blood]
+Keyword Heading
+ Western diet
+ meat
+ obesity
+ plant-based diet
+ saturated fat
+ virus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Bacterial endotoxin is a potent inflammatory antigen abundant in the human intestine. Endotoxins circulate in the blood at low concentrations in all healthy individuals. Elevated levels of circulatory endotoxins may cause inflammation with the development of chronic disease, either affecting metabolism, neurological disease, or resistance to viral and bacterial infections. The most important endotoxin is LPS, being a superantigen. In this narrative review, the effect of various food components to postprandially elevate circulating LPS and inflammatory markers is described. There is evidence that the intake of food enriched in fat, in particular saturated fat, may elevate LPS and pro-inflammatory markers. This occurs in both normal-weight and obese subjects. In obese subjects, inflammatory markers are already elevated before meal consumption. The importance of food choice for endotoxemia and inflammatory response is discussed.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fats). 0 (Lipopolysaccharides).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22179562
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Erlanson-Albertsson&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=The+Importance+of+Food+for+Endotoxemia+and+an+Inflammatory+Response.&volume=22&issue=17&spage=9562&epage=&date=2021&doi=10.3390%2Fijms22179562&pmid=34502470&sid=OVID:medline
+
+<755>
+Unique Identifier
+ 34498487
+Title
+ Biomarker profiles in obesity patients and their relation to cardiac dysfunction.
+Source
+ Biomarkers in Medicine. 15(14):1211-1221, 2021 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Snelder SM; Pouw N; Aga Y; Cabezas MC; Zijlstra F; Kardys I; van Dalen BM
+Author NameID
+ Snelder, Sanne M; ORCID: https://orcid.org/0000-0003-3330-1400
+Authors Full Name
+ Snelder, Sanne M; Pouw, Nadine; Aga, Yaar; Cabezas, Manuel C; Zijlstra, Felix; Kardys, Isabella; van Dalen, Bas M.
+Institution
+ Snelder, Sanne M. Department of Cardiology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
+ Pouw, Nadine. Department of Clinical Chemistry, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
+ Aga, Yaar. Department of Cardiology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
+ Cabezas, Manuel C. Department of Internal Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
+ Zijlstra, Felix. Department of Cardiology, Thoraxcenter, Erasmus University Medical Centre, Erasmus MC, Rotterdam, The Netherlands.
+ Kardys, Isabella. Department of Cardiology, Thoraxcenter, Erasmus University Medical Centre, Erasmus MC, Rotterdam, The Netherlands.
+ van Dalen, Bas M. Department of Cardiology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
+ van Dalen, Bas M. Department of Cardiology, Thoraxcenter, Erasmus University Medical Centre, Erasmus MC, Rotterdam, The Netherlands.
+MeSH Subject Headings
+ Adult
+ Atherosclerosis/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Female
+ *Heart Diseases/bl [Blood]
+ Humans
+ Inflammation/bl [Blood]
+ Insulin Resistance/ph [Physiology]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Risk Factors
+Keyword Heading
+ atherosclerosis
+ biomarkers
+ cardiac dysfunction
+ inflammation
+ insulin resistance
+ obesity/obese
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aim: Current knowledge on the role of obesity in causing cardiac dysfunction is insufficient. Several biomarkers reflecting biological processes that may play a role in the occurrence of cardiac dysfunction in obesity patients are available. Purpose: To compare cardiovascular biomarker profiles between obesity patients and nonobese controls, and between obesity patients with and without cardiac dysfunction, in order to better understand the underlying pathophysiology of cardiac dysfunction in obesity patients. Materials & methods: Blood samples were obtained from 100 obesity patients (BMI >=35 kg/m2) without known cardiovascular disease, and from 50 age- and gender-matched nonobese controls (BMI <=30 kg/m2). The third cardiovascular panel of the Olink Multiplex platform was used for the measurement of 92 biomarkers. Results: The majority (53%) of biomarkers were elevated in obesity patients compared with nonobese controls. Only 5% of the biomarkers were elevated in obesity patients with cardiac dysfunction compared with those without. Biomarkers discriminating cardiac dysfunction from no cardiac dysfunction in obesity patients differed from those discriminating obese from nonobese patients. An elastic net model for the prediction of cardiac dysfunction in obesity patients had a high area under the receiver operating curve of 0.87 (95% CI: 0.79-0.94; p < 0.001). The sensitivity of this model was 84% and the specificity was 79%. Conclusion: A multiplex immunoassay was used for the first time in obesity patients without known cardiovascular disease. These patients have cardiovascular biomarker profiles that are clearly different from nonobese controls. Comparison of obesity patients with and without cardiac dysfunction suggested an important role for inflammation, atherosclerosis and insulin resistance in the underlying pathophysiology of cardiac dysfunction in obesity patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.2217%2fbmm-2021-0101
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Snelder&issn=1752-0363&title=Biomarkers+in+Medicine&atitle=Biomarker+profiles+in+obesity+patients+and+their+relation+to+cardiac+dysfunction.&volume=15&issue=14&spage=1211&epage=1221&date=2021&doi=10.2217%2Fbmm-2021-0101&pmid=34498487&sid=OVID:medline
+
+<756>
+Unique Identifier
+ 34492746
+Title
+ The concordance between ultrasonographic stage of breast and Tanner stage of breast for overweight and obese girls: a school population-based study.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 34(12):1549-1558, 2021 Dec 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pan D; Fu S; Li X; Yu T; Huang S; Zhang B; Lai X; Liu Y; Yu X; Lin C; Liu S
+Author NameID
+ Liu, Shijian; ORCID: https://orcid.org/0000-0002-7050-463X
+Authors Full Name
+ Pan, Dongxue; Fu, Simao; Li, Xiaoqing; Yu, Tingting; Huang, Sizhe; Zhang, Bihong; Lai, Xin; Liu, Yifan; Yu, Xiaodan; Lin, Cuilan; Liu, Shijian.
+Institution
+ Pan, Dongxue. The Second School of Clinical Medicine, Southern Medical University, Guangzhou City, Guangdong Province, P. R. China.
+ Pan, Dongxue. BoAi Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan City, Guangdong Province, P. R. China.
+ Fu, Simao. Zhongshan City People's Hospital of Sun-Yat-Sen University, Zhongshan City, Guangdong Province, P. R. China.
+ Li, Xiaoqing. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
+ Li, Xiaoqing. Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
+ Yu, Tingting. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
+ Yu, Tingting. Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
+ Huang, Sizhe. Health Care Center for Primary and Secondary Schools, Zhongshan City, Guangdong province, P. R. China.
+ Zhang, Bihong. BoAi Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan City, Guangdong Province, P. R. China.
+ Lai, Xin. The Second School of Clinical Medicine, Southern Medical University, Guangzhou City, Guangdong Province, P. R. China.
+ Lai, Xin. BoAi Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan City, Guangdong Province, P. R. China.
+ Liu, Yifan. The Second School of Clinical Medicine, Southern Medical University, Guangzhou City, Guangdong Province, P. R. China.
+ Liu, Yifan. BoAi Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan City, Guangdong Province, P. R. China.
+ Yu, Xiaodan. Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center,School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
+ Lin, Cuilan. BoAi Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan City, Guangdong Province, P. R. China.
+ Liu, Shijian. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
+ Liu, Shijian. Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Breast/dg [Diagnostic Imaging]
+ *Breast/gd [Growth & Development]
+ Breast/me [Metabolism]
+ Case-Control Studies
+ Child
+ Female
+ Follicle Stimulating Hormone/bl [Blood]
+ Follow-Up Studies
+ Humans
+ Luteinizing Hormone/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ *Puberty
+ Retrospective Studies
+ Sexual Maturation
+ *Ultrasonography, Mammary/mt [Methods]
+Keyword Heading
+ Tanner stage of breast
+ breast bud diameter
+ hormones level
+ ultrasonographic stage of breast
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: In this study, we evaluated the concordance between the ultrasonographic stage of breast (US B) and Tanner stage of breast (TS B) for overweight and obese girls based on a school population study.
+
+ METHODS: We conducted multistage, stratified cluster, and random-proportional sampling and ultimately included 221 girls (aged 6-10 years).
+
+ RESULTS: This study revealed that the concordance was poor (accuracy=0.19 (95% confidence interval: 0.14, 0.25)) between US B and TS B among the 221 participants. When our subjects were stratified by weight, we observed a weak association between US B and TS B in the thin/normal weight group (r=0.34, p=0.001) but not in the overweight (r=0.097, p=0.38) or obese groups (r=-0.19, p=0.206), and as the body mass index (BMI) z-score increased, the overestimation ratio of TS B increased. US B manifested a positive correlation with breast bud diameter (BD) (r=0.885, p<0.001), follicle-stimulating hormone (r=0.235, p=0.009), and luteinizing hormone (r=0.192, p=0.037), but this was not the case with TS B.
+
+ CONCLUSIONS: As the BMI z-score increased, the correlation between the two methods declined, and the overestimation ratio of TS B increased. US B is an objective and quantitative method used to evaluate breast development, and whether BD might replace US B as a routine diagnostic method to evaluate breast development in clinical practice needs to be confirmed in larger-sample studies. Copyright © 2021 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9002-67-9 (Luteinizing Hormone). 9002-68-0 (Follicle Stimulating Hormone).
+Publication Type
+ Journal Article. Multicenter Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1515%2fjpem-2021-0181
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pan&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=The+concordance+between+ultrasonographic+stage+of+breast+and+Tanner+stage+of+breast+for+overweight+and+obese+girls%3A+a+school+population-based+study.&volume=34&issue=12&spage=1549&epage=1558&date=2021&doi=10.1515%2Fjpem-2021-0181&pmid=34492746&sid=OVID:medline
+
+<757>
+Unique Identifier
+ 34489970
+Title
+ Obesity Attenuates Ventilator-Induced Lung Injury by Modulating the STAT3-SOCS3 Pathway.
+Source
+ Frontiers in Immunology. 12:720844, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu SW; Peng CK; Wu SY; Wang Y; Yang SS; Tang SE; Huang KL
+Authors Full Name
+ Wu, Shih-Wei; Peng, Chung-Kan; Wu, Shu-Yu; Wang, Yu; Yang, Sung-Sen; Tang, Shih-En; Huang, Kun-Lun.
+Institution
+ Wu, Shih-Wei. Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.
+ Wu, Shih-Wei. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
+ Peng, Chung-Kan. Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.
+ Peng, Chung-Kan. Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
+ Wu, Shu-Yu. Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
+ Wang, Yu. Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
+ Yang, Sung-Sen. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
+ Yang, Sung-Sen. Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
+ Tang, Shih-En. Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.
+ Tang, Shih-En. Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
+ Huang, Kun-Lun. Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.
+ Huang, Kun-Lun. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
+ Huang, Kun-Lun. Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cytokines/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ Disease Progression
+ Disease Susceptibility
+ Gene Expression Regulation
+ Gene Knockdown Techniques
+ Mice
+ Mice, Knockout
+ NF-kappa B/me [Metabolism]
+ *Obesity/co [Complications]
+ Protein Serine-Threonine Kinases/me [Metabolism]
+ RNA Interference
+ *STAT3 Transcription Factor/me [Metabolism]
+ *Signal Transduction
+ Suppressor of Cytokine Signaling 3 Protein/ge [Genetics]
+ *Suppressor of Cytokine Signaling 3 Protein/me [Metabolism]
+ *Ventilator-Induced Lung Injury/co [Complications]
+ Ventilator-Induced Lung Injury/et [Etiology]
+ *Ventilator-Induced Lung Injury/me [Metabolism]
+Keyword Heading
+ WNK lysine deficient protein kinase 4 (WNK4)
+ alveolar fluid clearance (AFC)
+ hesperetin
+ obesity
+ suppressor of cytokine signaling 3 (SOCS3)
+ ventilator-induced lung injury (VILI)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Ventilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and suppression of alveolar fluid clearance (AFC). Obesity itself leads to chronic inflammation, which may initiate an injurious cascade to the lungs and simultaneously induce a protective feedback. In this study, we investigated the protective mechanism of obesity on VILI in a mouse model.
+
+ Methods: The VILI model was set up via 6-h mechanical ventilation with a high tidal volume. Parameters including lung injury score, STAT3/NFkappaB pathway, and AFC were assessed. Mice with diet-induced obesity were obtained by allowing free access to a high-fat diet since the age of 3 weeks. After a 9-week diet intervention, these mice were sacrificed at the age of 12 weeks. The manipulation of SOCS3 protein was achieved by siRNA knockdown and pharmaceutical stimulation using hesperetin. WNK4 knockin and knockout obese mice were used to clarify the pathway of AFC modulation.
+
+ Results: Obesity itself attenuated VILI. Knockdown of SOCS3 in obese mice offset the protection against VILI afforded by obesity. Hesperetin stimulated SOCS3 upregulation in nonobese mice and provided protection against VILI. In obese mice, the WNK4 axis was upregulated at the baseline, but was significantly attenuated after VILI compared with nonobese mice. At the baseline, the manipulation of SOCS3 by siRNA and hesperetin also led to the corresponding alteration of WNK4, albeit to a lesser extent. After VILI, WNK4 expression correlated with STAT3/NFkappaB activation, regardless of SOCS3 status. Obese mice carrying WNK4 knockout had VILI with a severity similar to that of wild-type obese mice. The severity of VILI in WNK4-knockin obese mice was counteracted by obesity, similar to that of wild-type nonobese mice only.
+
+ Conclusions: Obesity protects lungs from VILI by upregulating SOCS3, thus suppressing the STAT3/NFkappaB inflammatory pathway and enhancing WNK4-related AFC. However, WNK4 activation is mainly from direct NFkappaB downstreaming, and less from SOCS3 upregulation. Moreover, JAK2-STAT3/NFkappaB signaling predominates the pathogenesis of VILI. Nevertheless, the interaction between SOCS3 and WNK4 in modulating VILI in obesity warrants further investigation. Copyright © 2021 Wu, Peng, Wu, Wang, Yang, Tang and Huang.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (NF-kappa B). 0 (STAT3 Transcription Factor). 0 (Socs3 protein, mouse). 0 (Stat3 protein, mouse). 0 (Suppressor of Cytokine Signaling 3 Protein). EC 2-7-1 (Prkwnk4 protein, mouse). EC 2-7-1 (Stk39 protein, mouse). EC 2-7-11-1 (Protein Serine-Threonine Kinases).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffimmu.2021.720844
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Obesity+Attenuates+Ventilator-Induced+Lung+Injury+by+Modulating+the+STAT3-SOCS3+Pathway.&volume=12&issue=&spage=720844&epage=&date=2021&doi=10.3389%2Ffimmu.2021.720844&pmid=34489970&sid=OVID:medline
+
+<758>
+Unique Identifier
+ 34487291
+Title
+ Osteoprotegerin expression and serum values in obese women with type 2 diabetes mellitus.
+Source
+ Molecular Biology Reports. 48(11):7095-7104, 2021 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rashad NM; El-Shal AS; Shalaby SM; Abdel-Nour HM; Sarhan WM
+Author NameID
+ El-Shal, Amal S; ORCID: http://orcid.org/0000-0002-9142-1921
+Authors Full Name
+ Rashad, Nearmeen M; El-Shal, Amal S; Shalaby, Sally M; Abdel-Nour, Hanim M; Sarhan, Walaa M.
+Institution
+ Rashad, Nearmeen M. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
+ El-Shal, Amal S. Medical Biochemistry Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt. amalelshal@gmail.com.
+ El-Shal, Amal S. Medical Biochemistry Department and Molecular Biology, Military Armed Forces College of Medicine (AFCM), Cairo, Egypt. amalelshal@gmail.com.
+ Shalaby, Sally M. Medical Biochemistry Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.
+ Abdel-Nour, Hanim M. Medical Biochemistry Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.
+ Sarhan, Walaa M. Medical Biochemistry Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Diabetes Mellitus, Type 2
+ Egypt
+ Female
+ *Gene Expression Regulation
+ Humans
+ *Insulin Resistance/ge [Genetics]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ *Obesity
+ Osteoprotegerin/bl [Blood]
+ Osteoprotegerin/ge [Genetics]
+ *Osteoprotegerin
+Keyword Heading
+ Diabetes mellitus
+ Metabolic syndrome
+ Obesity
+ Osteoprotegerin
+ Real time polymerase chain reaction
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity and diabetes prevalence are increasing worldwide. We aimed to detect the possible association of osteoprotegerin (OPG) gene expression with visceral adiposity indices and cardiometabolic risk factors among obese women.
+
+ METHODS AND RESULTS: The study enrolled 150 controls and 150 obese cases subdivided into two subgroups non-diabetic (n = 70) and 80 patients with type 2 diabetes mellitus (T2DM). Circulating OPG gene expression levels were figured out by real time PCR (Polymerase Chain Reaction). Serum OPG levels were assessed by Enzyme Linked Immunosorbent Assay. Our results explored that OPG serum levels were lower in the obese women compared to control group (p < 0.001) and obese diabetics had higher serum levels of OPG in comparison to obese non-diabetic patients (p < 0.001). Expression levels of OPG were higher in obese women than controls (p < 0.001). Moreover, the blood expression levels of OPG gene were higher in diabetic obese patients than non-diabetics. We found positive correlations between parameters of metabolic syndrome and obesity indices. After adjustment of the traditional risk factors, stepwise linear regression analysis test revealed that OPG expression levels were independently correlated with glycated hemoglobin, high-density lipoprotein-cholesterol, and waist-to-hip ratio.
+
+ CONCLUSIONS: OPG mRNA levels were associated with surrogate markers of insulin resistance in Egyptian obese women. Copyright © 2021. The Author(s), under exclusive licence to Springer Nature B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Osteoprotegerin). 0 (TNFRSF11B protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs11033-021-06699-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rashad&issn=0301-4851&title=Molecular+Biology+Reports&atitle=Osteoprotegerin+expression+and+serum+values+in+obese+women+with+type+2+diabetes+mellitus.&volume=48&issue=11&spage=7095&epage=7104&date=2021&doi=10.1007%2Fs11033-021-06699-x&pmid=34487291&sid=OVID:medline
+
+<759>
+Unique Identifier
+ 34485532
+Title
+ The Relationship between Body Mass Index and Incident Diabetes Mellitus in Chinese Aged Population: A Cohort Study.
+Source
+ Journal of Diabetes Research. 2021:5581349, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tang ML; Zhou YQ; Song AQ; Wang JL; Wan YP; Xu RY
+Author NameID
+ Xu, R Y; ORCID: https://orcid.org/0000-0003-2608-5586
+Authors Full Name
+ Tang, M L; Zhou, Y Q; Song, A Q; Wang, J L; Wan, Y P; Xu, R Y.
+Institution
+ Tang, M L. Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
+ Zhou, Y Q. Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
+ Song, A Q. Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
+ Wang, J L. Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
+ Wan, Y P. Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
+ Xu, R Y. Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
+MeSH Subject Headings
+ Age Factors
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ China/ep [Epidemiology]
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ *Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Incidence
+ Male
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Time Factors
+Abstract
+ OBJECTIVES: Previous studies reported that overweight older adults had a lower mortality after cardiovascular diseases attack, indicating being thinner might not always be better. However, there is an ongoing debate about what is the optimal range of body mass index (BMI) for the aged population. We aimed to evaluate the value of BMI for the prediction of incident diabetes mellitus (DM) in the Chinese elderly population.
+
+ METHODS: A total number of 6,911 Chinese elderly people (4,110 men and 2,801 women, aged 71 +/- 6.0 years) were included in this cohort study. BMI was measured at baseline (Jan 1, 2014, to Dec 31, 2014). All the participants were further classified into six groups: <18.5 kg/m2, 18.5 to <22.5 kg/m2, 22.5 to <25.0 kg/m2, 25.0 to <27.5 kg/m2, 27.5 to <30.0 kg/m2, and >=30.0 kg/m2. Fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) were annually measured during follow-up (Jan 1, 2015-May 31, 2019). DM was confirmed if either FBG >= 7.0 mmol/L or HbA1c >= 6.5%. We used the Cox proportional hazard regression model to evaluate the association between BMI and the prediction of incident DM.
+
+ RESULTS: Comparing individuals with a BMI range of 18.5 to <22.5 kg/m2 (reference), the hazard ratio for incident DM was 2.13 (95% CI: 1.54~2.95), 2.14 (95% CI: 1.53~3.00), 3.17 (95% CI: 2.19~4.59), 3.15 (95% CI: 1.94~5.09), and 3.14 (95% CI: 1.94~5.09) for the group with a BMI range of 22.5 to <25.0 kg/m2, 25.0 to <27.5 kg/m2, 27.5 to <30.0 kg/m2, and >=30.0 kg/m2 after adjusting for baseline age, sex, blood pressure, lipid profiles, and eGFR (P trend < 0.001), after adjusting for the abovementioned confounders. The association tended to be closer in men and young participants, compared with their counterparts.
+
+ CONCLUSIONS: High BMI was associated with a high risk of developing DM in the Chinese aged population. Thus, it is optimal for the aged population to maintain their body weight within a reasonable range to prevent chronic diseases. Copyright © 2021 M. L. Tang et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f5581349
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tang&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=The+Relationship+between+Body+Mass+Index+and+Incident+Diabetes+Mellitus+in+Chinese+Aged+Population%3A+A+Cohort+Study.&volume=2021&issue=&spage=5581349&epage=&date=2021&doi=10.1155%2F2021%2F5581349&pmid=34485532&sid=OVID:medline
+
+<760>
+Unique Identifier
+ 34475467
+Title
+ Prevalence and related factors of dyslipidemia among urban adults aged 35 to 79 years in Southwestern China.
+Source
+ Scientific Reports. 11(1):17579, 2021 09 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang C; Zhang WQ; Tang WW; Liu Y; Liu JX; Xu RH; Zhao SP; Wang TD; Huang XB
+Authors Full Name
+ Huang, Chuan; Zhang, Wen-Qiang; Tang, Wei-Wei; Liu, Ya; Liu, Jian-Xiong; Xu, Rong-Hua; Zhao, Shui-Ping; Wang, Tzung-Dau; Huang, Xiao-Bo.
+Institution
+ Huang, Chuan. Department of Cardiology, the Second People's Hospital of Chengdu, Chengdu, Sichuan, China.
+ Zhang, Wen-Qiang. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
+ Tang, Wei-Wei. School of Health Policy and Management, Nanjing Medical University, Nanjing, Jiangsu Province, China.
+ Tang, Wei-Wei. Center for Global Health, Nanjing Medical University, Jiangsu Province, Nanjing, China.
+ Liu, Ya. Department of Endocrinology and Metabolism, Second People's Hospital of Chengdu, Chengdu, Sichuan, China.
+ Liu, Jian-Xiong. Department of Cardiology, the Second People's Hospital of Chengdu, Chengdu, Sichuan, China.
+ Xu, Rong-Hua. Stroke Center, Second People's Hospital of Chengdu, Chengdu, Sichuan, China.
+ Zhao, Shui-Ping. Department of Cardiology, Cent S Univ, Xiangya Hosp 2, Changsha, Hunan Province, China. zhaosp@csu.edu.cn.
+ Wang, Tzung-Dau. Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. tdwang@ntu.edu.tw.
+ Huang, Xiao-Bo. Department of Cardiology, the Second People's Hospital of Chengdu, Chengdu, Sichuan, China. drhuangxiaobo@126.com.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ China/ep [Epidemiology]
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/ep [Epidemiology]
+ Dyslipidemias/bl [Blood]
+ *Dyslipidemias/ep [Epidemiology]
+ Dyslipidemias/pa [Pathology]
+ Female
+ Humans
+ Hypertension/bl [Blood]
+ Hypertension/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Prognosis
+ Risk Factors
+Abstract
+ This study aimed to investigate the prevalence of dyslipidemia and its related factors among urban adults aged 35 to 79 years in Southwestern China. From September 2013 to March 2014, a multi-stage sampling was conducted, and a total of 10,221 people aged 35-79 years living in Chengdu and Chongqing were included. More than 30 investigators were trained in data collection, including questionnaire, anthropometric measurements and blood biomarkers testing. The prevalence of high triglycerides (>= 2.3 mmol/L), high total cholesterol (>= 6.2 mmol/L), high low-density lipoprotein cholesterol (>= 4.1 mmol/L), low high-density lipoprotein cholesterol (< 1.0 mmol/L), and dyslipidemia were 15.7% (95% confidence interval, 15.0-16.4%), 5.4% (4.9-5.8%), 2.5% (2.2-2.8%), 5.7% (5.3-6.2%), and 27.4% (26.5-28.2%), respectively. The prevalence of dyslipidemia was positively correlated with higher education level, monthly income over 2000 CNY, smoking, hypertension, diabetes, overweight and obesity, and central obesity, and negatively correlated with daily physical exercise. The prevalence of dyslipidemia in Southwestern China is lower than the national average level, with high triglycerides being the most common form of dyslipidemia. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-96864-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=2045-2322&title=Scientific+Reports&atitle=Prevalence+and+related+factors+of+dyslipidemia+among+urban+adults+aged+35+to+79+years+in+Southwestern+China.&volume=11&issue=1&spage=17579&epage=&date=2021&doi=10.1038%2Fs41598-021-96864-w&pmid=34475467&sid=OVID:medline
+
+<761>
+Unique Identifier
+ 34454459
+Title
+ Metabolic syndrome and its components are associated with thyroid volume in adolescents.
+Source
+ BMC Endocrine Disorders. 21(1):176, 2021 Aug 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xiao Y; Mao J; Mao X; Wang Q; Li X; Chen G; Guo L; Huang H; Mu Y; Xu S; Liu C
+Authors Full Name
+ Xiao, Yang; Mao, Jingjing; Mao, Xiaodong; Wang, Qifeng; Li, Xingjia; Chen, Guofang; Guo, Ling; Huang, Huaying; Mu, Yiming; Xu, Shuhang; Liu, Chao.
+Institution
+ Xiao, Yang. Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine (Jiangsu Province Hospital on Integration of Chinese and Western Medicine), Nanjing, China.
+ Mao, Jingjing. Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine (Jiangsu Province Hospital on Integration of Chinese and Western Medicine), Nanjing, China.
+ Mao, Xiaodong. Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine (Jiangsu Province Hospital on Integration of Chinese and Western Medicine), Nanjing, China.
+ Wang, Qifeng. Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine (Jiangsu Province Hospital on Integration of Chinese and Western Medicine), Nanjing, China.
+ Li, Xingjia. Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine (Jiangsu Province Hospital on Integration of Chinese and Western Medicine), Nanjing, China.
+ Chen, Guofang. Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine (Jiangsu Province Hospital on Integration of Chinese and Western Medicine), Nanjing, China.
+ Guo, Ling. Department of Endocrinology, Wujin Hospital of Traditional Chinese Medicine, Changzhou, China.
+ Huang, Huaying. Department of Endocrinology, Wujin Hospital of Traditional Chinese Medicine, Changzhou, China.
+ Mu, Yiming. Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
+ Xu, Shuhang. Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine (Jiangsu Province Hospital on Integration of Chinese and Western Medicine), Nanjing, China. shuhangxu@163.com.
+ Liu, Chao. Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine (Jiangsu Province Hospital on Integration of Chinese and Western Medicine), Nanjing, China. liuchao@nfmcn.com.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ Child
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ *Metabolic Syndrome/pp [Physiopathology]
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ Thyroid Gland/me [Metabolism]
+ *Thyroid Gland/pa [Pathology]
+Keyword Heading
+ Adolescents
+ Metabolic syndrome
+ Thyroid volume
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To explore the association between metabolic syndrome (MetS) and its component and thyroid volume in Chinese adolescents, and to compare the detection rate of MetS under the three different diagnostic criteria.
+
+ METHODS: A total of 1097 school students (610 males and 487 females, ages 12-15 years) were enrolled. All the participants underwent physical examination, biochemical test, and thyroid gland ultrasonography. The thyroid volume of normal, overweight and obese group was compared. We also analyzed the association between the number of MetS components and thyroid volume. Linear and multiple linear regression were applied to explore the association between metabolic parameters and thyroid volume.
+
+ RESULTS: The thyroid volume of the males in overweight (t = 3.784, P < 0.001) and obese group (t = 5.068, P < 0.001) was significantly larger than that in normal group; the thyroid volume of the females in overweight group (t = 4.627,P < 0.001) was significantly larger than that of normal group. As the number of MetS components increased, the thyroid volume also increased significantly (F = 10.64, P < 0.01). Height, weight, body mass index (BMI), waist circumference, hip circumference, systolic blood pressure, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), uric acid and triglyceride were all positively associated with thyroid volume in the adolescents (P all < 0.001). Meanwhile, there was a negative association between high-density lipoprotein cholesterol (HDL-C) and thyroid volume (P < 0.001). According to multiple linear regression, waist circumference (beta = 0.029, 95 %CI: 0.015 ~ 0.042; P < 0.01) and waist height ratio (beta = 3.317, 95 %CI: 1.661 ~ 4.973; P < 0.01) were predict factors of thyroid volume. No statistical difference was found in the detection rates of metabolic syndrome under the three diagnostic criteria.
+
+ CONCLUSIONS: Overweight, obesity and metabolic syndrome was associated with adolescent thyroid volume. Central obesity may be an independent risk factor for thyroid enlargement in adolescents. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12902-021-00833-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xiao&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Metabolic+syndrome+and+its+components+are+associated+with+thyroid+volume+in+adolescents.&volume=21&issue=1&spage=176&epage=&date=2021&doi=10.1186%2Fs12902-021-00833-3&pmid=34454459&sid=OVID:medline
+
+<762>
+Unique Identifier
+ 34452638
+Title
+ Prevalence and associated metabolic factors for thyroid nodules: a cross-sectional study in Southwest of China with more than 120 thousand populations.
+Source
+ BMC Endocrine Disorders. 21(1):175, 2021 Aug 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xu L; Zeng F; Wang Y; Bai Y; Shan X; Kong L
+Authors Full Name
+ Xu, Li; Zeng, Fanling; Wang, Yutong; Bai, Ye; Shan, Xuefeng; Kong, Lingxi.
+Institution
+ Xu, Li. Health Management Centre, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
+ Zeng, Fanling. Health Management Centre, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
+ Wang, Yutong. Department of Health Management Centre (Epidemiology and Biostatistics), First Affiliated Hospital, Army Medical University, 400038, Chongqing, China.
+ Bai, Ye. Department of Epidemiology and Health Statistics, School of Public Health and Management, Chongqing Medical University, 400016, Chongqing, China.
+ Shan, Xuefeng. Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China. 83846674@qq.com.
+ Kong, Lingxi. Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China. klingxi@126.com.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ *Biomarkers/me [Metabolism]
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ *Diabetes Mellitus/pp [Physiopathology]
+ *Fatty Liver/pp [Physiopathology]
+ Female
+ Humans
+ *Hypertension/pp [Physiopathology]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prevalence
+ Risk Factors
+ *Thyroid Nodule/ep [Epidemiology]
+ Thyroid Nodule/me [Metabolism]
+ Thyroid Nodule/pa [Pathology]
+Keyword Heading
+ Metabolic factors
+ Multiple thyroid nodules
+ Prevalence
+ Thyroid nodules
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To explore the prevalence and its associated metabolic factors of thyroid nodules (TNs) among subjects who participated in the physical examinations in Chongqing, China.
+
+ METHODS: The participants from the Health Management Center of JinShan Hospital of Chongqing Medical University, between September 2015 and May 2020, were included in this study. All of the participants underwent thyroid ultrasonography, anthropometric measurements, and serum examinations. Differences in the TNs prevalence were compared with the chi-square test or Wilcoxon rang-sum test. Multivariable logistic regression analyses were used to estimate the metabolic factors associated with TNs and multiple thyroid nodules (MTNs).
+
+ RESULTS: Of the included 121,702 participants, 41,547 had TNs, and 20,899 had MTNs, with the prevalence of 34.1 and 17.0 %, respectively. Women had a significantly higher prevalence of TNs than men (40.6 % vs. 29.8 %; chi2 = 1517.33, P < 0.001), and TNs prevalence was gradually increased with age (P for trend < 0.001). Female gender, advanced age, and metabolic factors including central obesity, hypertension, diabetes and fatty liver were positively associated with TNs; BMI, hyperlipoidemia and hyperuricemia were not independent risk factors of TNs. While female gender, advanced age, central obesity, hypertension and diabetes were independent risk factors of MTNs.
+
+ CONCLUSIONS: The prevalence of thyroid nodules was relatively high. The associated factors identified in this study could help the clinicians to detect the high-risk patients and make targeted screening strategies for the preventing of the occurrence of TNs. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12902-021-00842-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xu&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Prevalence+and+associated+metabolic+factors+for+thyroid+nodules%3A+a+cross-sectional+study+in+Southwest+of+China+with+more+than+120+thousand+populations.&volume=21&issue=1&spage=175&epage=&date=2021&doi=10.1186%2Fs12902-021-00842-2&pmid=34452638&sid=OVID:medline
+
+<763>
+Unique Identifier
+ 34445049
+Title
+ Relationship between 25 Hydroxyvitamin D, Overweight/Obesity Status, Pro-Inflammatory and Oxidative Stress Markers in Patients with Type 2 Diabetes: A Simplified Empirical Path Model.
+Source
+ Nutrients. 13(8), 2021 Aug 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Catoi AF; Iancu M; Parvu AE; Cecan AD; Bidian C; Chera EI; Pop ID; Macri AM
+Author NameID
+ Iancu, Mihaela; ORCID: https://orcid.org/0000-0002-4557-5364
+ Parvu, Alina Elena; ORCID: https://orcid.org/0000-0001-8937-8517
+ Pop, Ioana Delia; ORCID: https://orcid.org/0000-0002-6167-8232
+Authors Full Name
+ Catoi, Adriana Florinela; Iancu, Mihaela; Parvu, Alina Elena; Cecan, Andra Diana; Bidian, Cristina; Chera, Elisabeta Ioana; Pop, Ioana Delia; Macri, Adrian Maximilian.
+Institution
+ Catoi, Adriana Florinela. Department of Pathophysiology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
+ Iancu, Mihaela. Department of Medical Informatics and Biostatistics, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
+ Parvu, Alina Elena. Department of Pathophysiology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
+ Cecan, Andra Diana. Department of Pathophysiology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
+ Bidian, Cristina. Department of Physiology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
+ Chera, Elisabeta Ioana. Department of Pathophysiology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
+ Pop, Ioana Delia. Department of Exact Sciences, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania.
+ Macri, Adrian Maximilian. Department of Animal production and Food Safety, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania.
+MeSH Subject Headings
+ Adult
+ Aged
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Female
+ Humans
+ Inflammation
+ Insulin Resistance
+ Male
+ Middle Aged
+ *Nutritional Status/ph [Physiology]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Overweight/bl [Blood]
+ Overweight/co [Complications]
+ Oxidative Stress
+ Prevalence
+ Prospective Studies
+ *Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ Vitamin D Deficiency/co [Complications]
+ Vitamin D Deficiency/ep [Epidemiology]
+Keyword Heading
+ 25 hydroxyvitamin D
+ insulin resistance
+ overweight/obesity
+ oxidative stress
+ systemic inflammation
+ type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Vitamin D deficiency is highly prevalent in patients with overweight/obesity and type 2 diabetes (T2DM). Herein, we investigated the relationship between vitamin D status and overweight/obesity status, insulin resistance (IR), systemic inflammation as well as oxidative stress (OS). Anthropometric and laboratory assessments of 25-hydroxyvitamin D (25(OH)D) and glycemic, pro-inflammatory and OS biomarkers were performed in a sample of 47 patients with T2DM who were divided into categories based on overweight and degree of obesity. The main findings were: the overweight/obesity status correlated negatively with the degree of serum 25(OH)D deficiency (rho = -0.27) with a trend towards statistical significance (p = 0.069); the homeostasis model assessment of insulin resistance (HOMA-IR) was significantly different (p = 0.024) in patients with 25(OH)D deficiency, as was total oxidant status (TOS) and oxidative stress index (OSI) in patients with severe serum 25(OH)D deficiency as compared to those with 25(OH)D over 20 ng/mL (TOS: p = 0.007, OSI: p = 0.008); and 25(OH)D had a negative indirect effect on TOS by body mass index (BMI), but BMI was not a significant mediator of the studied relationship. In a setting of overweight and increasing degree of obesity, patients with T2DM did not display decreasing values of 25(OH)D. Subjects with the lowest values of 25(OH)D presented the highest values of BMI. Patients with 25(OH)D deficiency were more insulin resistant and showed increased OS but no elevated systemic inflammation. The negative effect of 25(OH)D on TOS did not seem to involve BMI as a mediator.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 1406-16-2 (Vitamin D). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13082889
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Catoi&issn=2072-6643&title=Nutrients&atitle=Relationship+between+25+Hydroxyvitamin+D%2C+Overweight%2FObesity+Status%2C+Pro-Inflammatory+and+Oxidative+Stress+Markers+in+Patients+with+Type+2+Diabetes%3A+A+Simplified+Empirical+Path+Model.&volume=13&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fnu13082889&pmid=34445049&sid=OVID:medline
+
+<764>
+Unique Identifier
+ 34444991
+Title
+ A Review of the Properties of Anthocyanins and Their Influence on Factors Affecting Cardiometabolic and Cognitive Health. [Review]
+Source
+ Nutrients. 13(8), 2021 Aug 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ockermann P; Headley L; Lizio R; Hansmann J
+Authors Full Name
+ Ockermann, Philipp; Headley, Laura; Lizio, Rosario; Hansmann, Jan.
+Institution
+ Ockermann, Philipp. Institute for Tissue Engineering and Regenerative Medicine, University Hospital Wuerzburg, Roentgenring 11, 97070 Wuerzburg, Germany.
+ Headley, Laura. Evonik Operations GmbH, 64293 Darmstadt, Germany.
+ Lizio, Rosario. Evonik Operations GmbH, 63457 Hanau, Germany.
+ Hansmann, Jan. Institute for Tissue Engineering and Regenerative Medicine, University Hospital Wuerzburg, Roentgenring 11, 97070 Wuerzburg, Germany.
+MeSH Subject Headings
+ Adult
+ Animals
+ *Anthocyanins
+ *Antioxidants
+ Biomarkers
+ Blood Pressure/de [Drug Effects]
+ Blood Pressure/ph [Physiology]
+ Cardiovascular Physiological Phenomena
+ Cognition/ph [Physiology]
+ Female
+ *Heart Disease Risk Factors
+ Humans
+ Inflammation
+ Male
+ Mice
+ Middle Aged
+ Obesity
+ Oxidative Stress
+Keyword Heading
+ anthocyanins
+ antioxidative
+ blood pressure
+ diabetes
+ hyperlipidemia
+ inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The incidence of cardiovascular and metabolic diseases has increased over the last decades and is an important cause of death worldwide. An upcoming ingredient on the nutraceutical market are anthocyanins, a flavonoid subgroup, abundant mostly in berries and fruits. Epidemiological studies have suggested an association between anthocyanin intake and improved cardiovascular risk, type 2 diabetes and myocardial infarct. Clinical studies using anthocyanins have shown a significant decrease in inflammation markers and oxidative stress, a beneficial effect on vascular function and hyperlipidemia by decreasing low-density lipoprotein and increasing high-density lipoprotein. They have also shown a potential effect on glucose homeostasis and cognitive decline. This review summarizes the effects of anthocyanins in in-vitro, animal and human studies to give an overview of their application in medical prevention or as a dietary supplement.
+Registry Number/Name of Substance
+ 0 (Anthocyanins). 0 (Antioxidants). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13082831
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ockermann&issn=2072-6643&title=Nutrients&atitle=A+Review+of+the+Properties+of+Anthocyanins+and+Their+Influence+on+Factors+Affecting+Cardiometabolic+and+Cognitive+Health.&volume=13&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fnu13082831&pmid=34444991&sid=OVID:medline
+
+<765>
+Unique Identifier
+ 34444866
+Title
+ Plasma Imidazole Propionate Is Positively Correlated with Blood Pressure in Overweight and Obese Humans.
+Source
+ Nutrients. 13(8), 2021 Aug 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van Son J; Serlie MJ; Stahlman M; Backhed F; Nieuwdorp M; Aron-Wisnewsky J
+Author NameID
+ van Son, Jamie; ORCID: https://orcid.org/0000-0002-9876-2876
+ Stahlman, Marcus; ORCID: https://orcid.org/0000-0002-4202-0339
+ Backhed, Fredrik; ORCID: https://orcid.org/0000-0002-4871-8818
+ Aron-Wisnewsky, Judith; ORCID: https://orcid.org/0000-0002-3104-9769
+Authors Full Name
+ van Son, Jamie; Serlie, Mireille J; Stahlman, Marcus; Backhed, Fredrik; Nieuwdorp, Max; Aron-Wisnewsky, Judith.
+Institution
+ van Son, Jamie. Department of Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ van Son, Jamie. Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Serlie, Mireille J. Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Stahlman, Marcus. Wallenberg Laboratory, University of Gothenburg, Bruna Straket 16, SE-413 45 Gothenburg, Sweden.
+ Backhed, Fredrik. Wallenberg Laboratory, University of Gothenburg, Bruna Straket 16, SE-413 45 Gothenburg, Sweden.
+ Backhed, Fredrik. Department of Clinical Physiology, Sahlgrenska University Hospital, Region Vastra Gotaland, Bla Straket 5, SE-413 45 Gothenburg, Sweden.
+ Backhed, Fredrik. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
+ Nieuwdorp, Max. Department of Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Nieuwdorp, Max. Department of Internal Medicine, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Aron-Wisnewsky, Judith. Department of Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
+ Aron-Wisnewsky, Judith. Nutrition and Obesities, Systemic Approaches (NutriOmics) Research Group, Sorbonne Universite, Inserm, 75013 Paris, France.
+ Aron-Wisnewsky, Judith. Assistante Publique Hopitaux de Paris, Nutrition Department, Pitie-Salpetriere Hospital, CRNH Ile de France, 75013 Paris, France.
+MeSH Subject Headings
+ *Bacteria/me [Metabolism]
+ Biomarkers/bl [Blood]
+ *Blood Pressure
+ Female
+ *Gastrointestinal Microbiome
+ Humans
+ *Imidazoles/bl [Blood]
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/mi [Microbiology]
+ Obesity/pp [Physiopathology]
+Keyword Heading
+ cardiovascular disease
+ gut microbiota
+ hyperinsulinemic-euglycemic clamp
+ imidazole propionate
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The gut microbiota and its metabolites are essential for host health and dysbiosis has been involved in several pathologic conditions such as type 2 diabetes (T2D) and cardiovascular disease (CVD). Recent studies have identified that plasma imidazole propionate (ImP), a microbial-produced metabolite, is increased in patients with prediabetes and T2D. More recently, ImP was found to be significantly increased in patients with overt CVD. Here, we aimed to investigate the association between ImP and CVD risk factors: blood pressure, HDL-cholesterol, LDL-cholesterol and insulin-resistance in overweight and obese subjects without T2D or use of any metabolic diseases-related medication.
+
+ METHODS: Plasma metabolites, including ImP, were determined in 107 male or post-menopausal women with overweight/obesity, but without T2D. Insulin-sensitivity was assessed with the gold standard method: the hyperinsulinemic-euglycemic clamp using the isotope [6,6-2H2] glucose and expressed as glucose rate of disposal (Rd) for peripheral insulin sensitivity and suppression of endogenous glucose production (EGP) for hepatic insulin sensitivity.
+
+ RESULTS: Partial correlation analysis controlled for BMI and age showed a significant correlation between ImP and diastolic blood pressure (rs = 0.285, p = 0.004) and a borderline significance with systolic blood pressure (rs = 0.187, p = 0.060); however, systolic and diastolic blood pressure did not correlate with ImP precursor histidine (rs = 0.063, p = 0.526 and r = -0.038, p = 0.712, respectively). We did not find a correlation between ImP with LDL-cholesterol or HDL-cholesterol (rs = -0.181, p = 0.064 and rs = 0.060, p = 0.546, respectively). Furthermore, there was no association between plasma ImP concentrations and Rd and EGP suppression.
+
+ CONCLUSION: In this cohort with overweight/obese subjects without T2D, plasma ImP concentrations were positively correlated with diastolic blood pressure but not with insulin-sensitivity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Imidazoles). 0 (Lipids). 1074-59-5 (5-imidazolepropionic acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13082706
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+Son&issn=2072-6643&title=Nutrients&atitle=Plasma+Imidazole+Propionate+Is+Positively+Correlated+with+Blood+Pressure+in+Overweight+and+Obese+Humans.&volume=13&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fnu13082706&pmid=34444866&sid=OVID:medline
+
+<766>
+Unique Identifier
+ 34444779
+Title
+ Effects of Cranberry Juice Supplementation on Cardiovascular Disease Risk Factors in Adults with Elevated Blood Pressure: A Randomized Controlled Trial.
+Source
+ Nutrients. 13(8), 2021 Jul 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Richter CK; Skulas-Ray AC; Gaugler TL; Meily S; Petersen KS; Kris-Etherton PM
+Author NameID
+ Richter, Chesney K; ORCID: https://orcid.org/0000-0002-5658-6173
+ Gaugler, Trent L; ORCID: https://orcid.org/0000-0002-8006-9184
+ Petersen, Kristina S; ORCID: https://orcid.org/0000-0003-3914-0353
+Authors Full Name
+ Richter, Chesney K; Skulas-Ray, Ann C; Gaugler, Trent L; Meily, Stacey; Petersen, Kristina S; Kris-Etherton, Penny M.
+Institution
+ Richter, Chesney K. Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85716, USA.
+ Skulas-Ray, Ann C. Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85716, USA.
+ Gaugler, Trent L. Department of Mathematics, Lafayette College, Easton, PA 18042, USA.
+ Meily, Stacey. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA.
+ Petersen, Kristina S. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA.
+ Petersen, Kristina S. Department of Nutritional Sciences, Texas Tech University, Lubbock, TX 79409, USA.
+ Kris-Etherton, Penny M. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Pressure/de [Drug Effects]
+ C-Reactive Protein/me [Metabolism]
+ *Cardiovascular Diseases/dh [Diet Therapy]
+ Cholesterol/bl [Blood]
+ *Dietary Supplements
+ Female
+ *Fruit and Vegetable Juices
+ Humans
+ *Hypertension/dh [Diet Therapy]
+ Lipoproteins/bl [Blood]
+ Male
+ Middle Aged
+ Obesity
+ Overweight
+ Risk Factors
+ *Vaccinium macrocarpon
+ Vascular Stiffness
+Keyword Heading
+ LDL-C
+ arterial stiffness
+ blood pressure
+ inflammatory markers
+ lipids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Emerging cardiovascular disease (CVD) risk factors, including central vascular function and HDL efflux, may be modifiable with food-based interventions such as cranberry juice. A randomized, placebo-controlled, crossover trial was conducted in middle-aged adults with overweight/obesity (n = 40; mean BMI: 28.7 +/- 0.8 kg/m2; mean age: 47 +/- 2 years) and elevated brachial blood pressure (mean systolic/diastolic BP: 124 +/- 2/81 +/- 1 mm Hg). Study participants consumed 500 mL/d of cranberry juice (~16 fl oz; 27% cranberry juice) or a matched placebo juice in a randomized order (8-week supplementation periods; 8-week compliance break), with blood samples and vascular measurements obtained at study entry and following each supplementation period. There was no significant treatment effect of cranberry juice supplementation on the primary endpoint of central systolic blood pressure or central or brachial diastolic pressure. Cranberry juice significantly reduced 24-h diastolic ambulatory BP by ~2 mm Hg compared to the placebo (p = 0.05) during daytime hours. Cranberry juice supplementation did not alter LDL-C but significantly changed the composition of the lipoprotein profile compared to the placebo, increasing the concentration of large LDL-C particles (+29.5 vs. -6.7 nmol/L; p = 0.02) and LDL size (+0.073 vs. -0.068 nm; p = 0.001). There was no effect of treatment on ex vivo HDL efflux in the total population, but exploratory subgroup analyses identified an interaction between BMI and global HDL efflux (p = 0.02), with greater effect of cranberry juice in participants who were overweight. Exploratory analyses indicate that baseline C-reactive protein (CRP) values may moderate treatment effects. In this population of adults with elevated blood pressure, cranberry juice supplementation had no significant effect on central systolic blood pressure but did have modest effects on 24-h diastolic ambulatory BP and the lipoprotein profile. Future studies are needed to verify these findings and the results of our exploratory analyses related to baseline health moderators.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipoproteins). 9007-41-4 (C-Reactive Protein). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13082618
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Richter&issn=2072-6643&title=Nutrients&atitle=Effects+of+Cranberry+Juice+Supplementation+on+Cardiovascular+Disease+Risk+Factors+in+Adults+with+Elevated+Blood+Pressure%3A+A+Randomized+Controlled+Trial.&volume=13&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fnu13082618&pmid=34444779&sid=OVID:medline
+
+<767>
+Unique Identifier
+ 34444736
+Title
+ Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats.
+Source
+ Nutrients. 13(8), 2021 Jul 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Michicotl-Meneses MM; Thompson-Bonilla MDR; Reyes-Lopez CA; Garcia-Perez BE; Lopez-Tenorio II; Ordaz-Pichardo C; Jaramillo-Flores ME
+Author NameID
+ Michicotl-Meneses, Maria Monica; ORCID: https://orcid.org/0000-0002-9842-5562
+ Reyes-Lopez, Cesar A; ORCID: https://orcid.org/0000-0002-9860-8983
+ Garcia-Perez, Blanca Estela; ORCID: https://orcid.org/0000-0001-6610-5559
+ Ordaz-Pichardo, Cynthia; ORCID: https://orcid.org/0000-0002-0938-3365
+Authors Full Name
+ Michicotl-Meneses, Maria Monica; Thompson-Bonilla, Maria Del Rocio; Reyes-Lopez, Cesar A; Garcia-Perez, Blanca Estela; Lopez-Tenorio, Itzel I; Ordaz-Pichardo, Cynthia; Jaramillo-Flores, Maria Eugenia.
+Institution
+ Michicotl-Meneses, Maria Monica. Departamento de Ingenieria Bioquimica, Instituto Politecnico Nacional, Escuela Nacional de Ciencias Biologicas, Mexico City 07738, Mexico.
+ Thompson-Bonilla, Maria Del Rocio. Laboratorio de Medicina Genomica, Investigacion Biomedica y Traslacional, ISSSTE, Hospital Regional "1degree de Octubre", Mexico City 07760, Mexico.
+ Reyes-Lopez, Cesar A. Laboratorio de Bioquimica Estructural, Instituto Politecnico Nacional, Escuela Nacional de Medicina y Homeopatia, Mexico City 07320, Mexico.
+ Garcia-Perez, Blanca Estela. Laboratorio de Microbiologia General, Instituto Politecnico Nacional, Escuela Nacional de Ciencias Biologicas, Mexico City 11340, Mexico.
+ Lopez-Tenorio, Itzel I. Departamento de Ingenieria Bioquimica, Instituto Politecnico Nacional, Escuela Nacional de Ciencias Biologicas, Mexico City 07738, Mexico.
+ Ordaz-Pichardo, Cynthia. Laboratorio de Biologia Celular y Productos Naturales, Instituto Politecnico Nacional, Escuela Nacional de Medicina y Homeopatia, Mexico City 07320, Mexico.
+ Jaramillo-Flores, Maria Eugenia. Departamento de Ingenieria Bioquimica, Instituto Politecnico Nacional, Escuela Nacional de Ciencias Biologicas, Mexico City 07738, Mexico.
+MeSH Subject Headings
+ Adiponectin/me [Metabolism]
+ Adipose Tissue/im [Immunology]
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers/an [Analysis]
+ Blood Pressure
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Chemokine CCL2/ai [Antagonists & Inhibitors]
+ Cytokines/me [Metabolism]
+ Diet, High-Fat
+ Energy Intake
+ Fruit and Vegetable Juices/an [Analysis]
+ *Fruit and Vegetable Juices
+ *Heart Disease Risk Factors
+ *Inflammation
+ Lipids/bl [Blood]
+ Male
+ Obesity/co [Complications]
+ *Obesity/pp [Physiopathology]
+ *Pomegranate
+ Rats
+ Rats, Wistar
+Keyword Heading
+ anthocyanins
+ atherosclerosis vascular risk
+ high-fat diet
+ inflammation
+ obesity
+ pomegranate juice
+ pro-inflammatory cytokines
+ selectin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pomegranate juice (Punica granatum) has been used since ancient times in traditional medicine (Unani Medicine, Ayurveda); its main compounds are anthocyanins and ellagic acid, which have anti-inflammatory, antioxidant, hepatoprotective, and cardiovascular health effects. The objective was to evaluate the effect of pomegranate juice on inflammation, blood pressure, and vascular and physiological markers associated with obesity induced by a high-fat diet in a murine model. The results show that pomegranate juice reduces the concentration of low-density lipoprotein cholesterol (cLDL) 39% and increases the concentration of high-density lipoprotein cholesterol (cHDL) by 27%, leading to a 12%-18% decrease in the risk of cardiovascular diseases (CVD). In addition to reducing blood pressure by 24%, it also had an antiatherogenic effect by decreasing sE-selectin levels by 42%. On the other hand, the juice significantly increased adiponectin levels in adipose tissue, decreased levels of inflammation markers (tumor necrosis factor-alpha (TNF-alpha), plasminogen activator inhibitor-1 (PAI-1), interleukin-17A (IL-17A), interleukin-6 (IL-6), interleukin-1beta (IL-1beta)), and inhibited the monocyte chemoattractant protein-1 (MCP-1). Pomegranate juice requires clinical studies to prove its immunoregulatory and therapeutic effects on cardiovascular and atherogenic risks.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Ccl2 protein, rat). 0 (Chemokine CCL2). 0 (Cytokines). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13082577
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Michicotl-Meneses&issn=2072-6643&title=Nutrients&atitle=Inflammation+Markers+in+Adipose+Tissue+and+Cardiovascular+Risk+Reduction+by+Pomegranate+Juice+in+Obesity+Induced+by+a+Hypercaloric+Diet+in+Wistar+Rats.&volume=13&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fnu13082577&pmid=34444736&sid=OVID:medline
+
+<768>
+Unique Identifier
+ 34444671
+Title
+ Effects of 60-Day Saccharomyces boulardii and Superoxide Dismutase Supplementation on Body Composition, Hunger Sensation, Pro/Antioxidant Ratio, Inflammation and Hormonal Lipo-Metabolic Biomarkers in Obese Adults: A Double-Blind, Placebo-Controlled Trial.
+Source
+ Nutrients. 13(8), 2021 Jul 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rondanelli M; Miraglia N; Putignano P; Castagliuolo I; Brun P; Dall'Acqua S; Peroni G; Faliva MA; Naso M; Nichetti M; Infantino V; Perna S
+Author NameID
+ Rondanelli, Mariangela; ORCID: https://orcid.org/0000-0001-8336-4851
+ Brun, Paola; ORCID: https://orcid.org/0000-0002-3279-9000
+ Dall'Acqua, Stefano; ORCID: https://orcid.org/0000-0001-8264-6953
+ Peroni, Gabriella; ORCID: https://orcid.org/0000-0002-1632-1787
+ Infantino, Vittoria; ORCID: https://orcid.org/0000-0001-8172-5182
+ Perna, Simone; ORCID: https://orcid.org/0000-0002-2720-1473
+Authors Full Name
+ Rondanelli, Mariangela; Miraglia, Niccolo; Putignano, Pietro; Castagliuolo, Ignazio; Brun, Paola; Dall'Acqua, Stefano; Peroni, Gabriella; Faliva, Milena Anna; Naso, Maurizio; Nichetti, Mara; Infantino, Vittoria; Perna, Simone.
+Institution
+ Rondanelli, Mariangela. Department of Public Health, IRCCS Mondino Foundation, 27100 Pavia, Italy.
+ Rondanelli, Mariangela. Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
+ Miraglia, Niccolo. Clinical & Pre-Clinical Development, Gnosis SpA, 20121 Milan, Italy.
+ Miraglia, Niccolo. Business Unit of the Lesaffre Group, Lesaffre, 59703 Marcq-en-Baroeul, France.
+ Putignano, Pietro. SP Diabetic Outpatient Clinic, ASST Monza, 20900 Monza, Italy.
+ Castagliuolo, Ignazio. Department of Molecular Medicine, University of Padova, 35121 Padova, Italy.
+ Brun, Paola. Department of Molecular Medicine, University of Padova, 35121 Padova, Italy.
+ Dall'Acqua, Stefano. Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
+ Peroni, Gabriella. Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100 Pavia, Italy.
+ Faliva, Milena Anna. Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100 Pavia, Italy.
+ Naso, Maurizio. Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100 Pavia, Italy.
+ Nichetti, Mara. Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100 Pavia, Italy.
+ Infantino, Vittoria. Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
+ Perna, Simone. Department of Biology, Sakhir Campus, College of Science, University of Bahrain, Sakhir 32038, Bahrain.
+MeSH Subject Headings
+ Aged
+ Antioxidants/ad [Administration & Dosage]
+ *Biomarkers/bl [Blood]
+ Body Composition
+ Body Mass Index
+ Dietary Supplements
+ Double-Blind Method
+ Female
+ Humans
+ Hunger
+ Inflammation/bl [Blood]
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Placebos
+ *Probiotics/ad [Administration & Dosage]
+ *Saccharomyces boulardii
+ *Superoxide Dismutase/ad [Administration & Dosage]
+ Vitamin D/bl [Blood]
+ Weight Loss
+Keyword Heading
+ Saccharomyces boulardii
+ obesity
+ superoxide dismutase
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In animals it has been demonstrated that Saccharomyces boulardii and Superoxide Dismutase (SOD) decrease low-grade inflammation and that S. boulardii can also decrease adiposity. The purpose of this study was to evaluate the effect of a 60-day S. boulardii and SOD supplementation on circulating markers of inflammation, body composition, hunger sensation, pro/antioxidant ratio, hormonal, lipid profile, glucose, insulin and HOMA-IR, in obese adults (BMI 30-35 kg/m2). Twenty-five obese adults were randomly assigned to intervention (8/4 women/men, 57 +/- 8 years) or Placebo (9/4 women/men, 50 +/- 9 years). Intervention group showed a statistically significant (p < 0.05) decrease of body weight, BMI, fat mass, insulin, HOMA Index and uric acid. Patients in intervention and control groups showed a significant decrease (p < 0.05) of GLP-1. Intervention group showed an increase (p < 0.05) of Vitamin D as well. In conclusion, the 60-day S. boulardii-SOD supplementation in obese subjects determined a significant weight loss with consequent decrease on fat mass, with preservation of fat free mass. The decrease of HOMA index and uric acid, produced additional benefits in obesity management. The observed increase in vitamin D levels in treated group requires further investigation.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Insulin). 0 (Lipids). 0 (Placebos). 1406-16-2 (Vitamin D). EC 1-15-1-1 (Superoxide Dismutase).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13082512
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rondanelli&issn=2072-6643&title=Nutrients&atitle=Effects+of+60-Day+Saccharomyces+boulardii+and+Superoxide+Dismutase+Supplementation+on+Body+Composition%2C+Hunger+Sensation%2C+Pro%2FAntioxidant+Ratio%2C+Inflammation+and+Hormonal+Lipo-Metabolic+Biomarkers+in+Obese+Adults%3A+A+Double-Blind%2C+Placebo-Controlled+Trial.&volume=13&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fnu13082512&pmid=34444671&sid=OVID:medline
+
+<769>
+Unique Identifier
+ 34427732
+Title
+ Metabolic effects of high-intensity interval training and essential amino acids.
+Source
+ European Journal of Applied Physiology. 121(12):3297-3311, 2021 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hirsch KR; Greenwalt CE; Cabre HE; Gould LM; Brewer GJ; Blue MNM; Ferrando AA; Huffman KM; Mayer-Davis EJ; Ryan ED; Smith-Ryan AE
+Author NameID
+ Hirsch, Katie R; ORCID: http://orcid.org/0000-0002-0899-0139
+Authors Full Name
+ Hirsch, Katie R; Greenwalt, Casey E; Cabre, Hannah E; Gould, Lacey M; Brewer, Gabrielle J; Blue, Malia N M; Ferrando, Arny A; Huffman, Kim M; Mayer-Davis, Elizabeth J; Ryan, Eric D; Smith-Ryan, Abbie E.
+Institution
+ Hirsch, Katie R. Department of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA. krhirsch@uams.edu.
+ Greenwalt, Casey E. Department of Nutrition, Food and Exercise Sciences, Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, USA.
+ Cabre, Hannah E. Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+ Cabre, Hannah E. Department of Allied Health Science, Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+ Gould, Lacey M. Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+ Brewer, Gabrielle J. Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, CT, USA.
+ Blue, Malia N M. Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+ Ferrando, Arny A. Department of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
+ Huffman, Kim M. Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
+ Huffman, Kim M. Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
+ Mayer-Davis, Elizabeth J. Department of Nutrition, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+ Mayer-Davis, Elizabeth J. Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
+ Ryan, Eric D. Department of Allied Health Science, Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+ Ryan, Eric D. Neuromuscular Assessment Laboratory, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, USA.
+ Smith-Ryan, Abbie E. Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+ Smith-Ryan, Abbie E. Department of Allied Health Science, Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+ Smith-Ryan, Abbie E. Department of Nutrition, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
+MeSH Subject Headings
+ Adult
+ *Amino Acids, Essential/ad [Administration & Dosage]
+ Biomarkers/bl [Blood]
+ Body Composition
+ Body Mass Index
+ Cardiorespiratory Fitness
+ Energy Metabolism
+ Female
+ *High-Intensity Interval Training
+ Humans
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+ *Overweight/me [Metabolism]
+Keyword Heading
+ Cardiometabolic health
+ Exercise
+ Interval exercise
+ Nutrition
+ Protein
+ Sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ High-intensity interval training (HIIT) promotes positive cardiometabolic and body composition changes. Essential amino acids (EAA) may support changes associated with HIIT, but evaluation of potential synergistic effects is lacking. The purpose of this study was to compare independent and combined effects of HIIT and EAA on total body composition and metabolism in men and women considered overweight/obese; an exploratory aim was to evaluate the modulatory effects of sex. Sixty-six healthy adults (50% female; Age: 36.7 +/- 6.0 years; BMI: 32.0 +/- 4.2 kg/m2) completed 8 weeks of: (1) HIIT, 2 days/weeks; (2) EAA supplementation, 3.6 g twice daily; (3) HIIT + EAA; or (4) control. Body composition, resting metabolic rate (RMR), substrate metabolism (respiratory exchange ratio; RER), and cardiorespiratory fitness were measured at baseline, 4 weeks, and 8 weeks; cardiometabolic blood markers were measured at baseline and 8 weeks. Differences between groups were assessed by linear mixed models covaried for baseline values, followed by 95% confidence intervals (CI) on adjusted mean change scores. There were no significant changes in body composition (p > 0.05) for any group. Changes in RER, but not RMR, occurred with HIIT (mean change; [95% CI]: - 0.04; [- 0.07, - 0.02]) and EAA (- 0.03; [- 0.06, - 0.01]) after 8 weeks. Cardiorespiratory fitness increased following 8 weeks of HIIT (+ 5.1 ml/kg/min [3.3,6.8]) and HIIT + EAA (+ 4.1 ml/kg/min [1.0,6.4]). Changes with HIIT + EAA were not significantly different from HIIT. There were no changes in cardiometabolic markers (p > 0.05) and no sex interaction (p > 0.05). HIIT is efficacious for promoting positive changes in cardiorespiratory fitness and resting substrate metabolism in adults considered overweight/obese. Addition of EAA did not significantly enhance HIIT-induced adaptations. ClinicalTrials.gov ID#NCT04080102. Copyright © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Essential). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs00421-021-04792-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hirsch&issn=1439-6319&title=European+Journal+of+Applied+Physiology&atitle=Metabolic+effects+of+high-intensity+interval+training+and+essential+amino+acids.&volume=121&issue=12&spage=3297&epage=3311&date=2021&doi=10.1007%2Fs00421-021-04792-4&pmid=34427732&sid=OVID:medline
+
+<770>
+Unique Identifier
+ 34426770
+Title
+ Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity.
+Source
+ Journal of Obesity. 2021:3620147, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chang SL; Tchernof A; Durocher F; Diorio C
+Author NameID
+ Chang, Sue-Ling; ORCID: https://orcid.org/0000-0003-3440-4102
+ Tchernof, Andre; ORCID: https://orcid.org/0000-0002-2587-1000
+ Durocher, Francine; ORCID: https://orcid.org/0000-0001-8012-4641
+ Diorio, Caroline; ORCID: https://orcid.org/0000-0001-5355-7345
+Authors Full Name
+ Chang, Sue-Ling; Tchernof, Andre; Durocher, Francine; Diorio, Caroline.
+Institution
+ Chang, Sue-Ling. CHU de Quebec Research Center, Laval University, Quebec, QC, Canada.
+ Chang, Sue-Ling. Laval University Cancer Research Center, Quebec, QC, Canada.
+ Tchernof, Andre. CHU de Quebec Research Center, Laval University, Quebec, QC, Canada.
+ Tchernof, Andre. School of Nutrition, Faculty of Agriculture and Food Sciences, Laval University, Quebec, QC, Canada.
+ Tchernof, Andre. Quebec Heart Lung Institute, Quebec, QC, Canada.
+ Durocher, Francine. CHU de Quebec Research Center, Laval University, Quebec, QC, Canada.
+ Durocher, Francine. Laval University Cancer Research Center, Quebec, QC, Canada.
+ Durocher, Francine. Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, QC, Canada.
+ Diorio, Caroline. CHU de Quebec Research Center, Laval University, Quebec, QC, Canada.
+ Diorio, Caroline. Laval University Cancer Research Center, Quebec, QC, Canada.
+ Diorio, Caroline. Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec, QC, Canada.
+ Diorio, Caroline. Deschenes-Fabia Center for Breast Diseases, Quebec, QC, Canada.
+MeSH Subject Headings
+ Adipose Tissue
+ *Adiposity
+ Biomarkers
+ Body Mass Index
+ *Breast Neoplasms
+ Female
+ Humans
+ Inflammation
+ Obesity
+ Waist Circumference
+Abstract
+ Background: Mechanisms underlying the obesity-breast cancer link involve inflammation but need to be elucidated. Determining obesity by combining body mass index (BMI) with the waist circumference (WC) may clarify the role of inflammatory and hormonally related markers in breast cancer. We examined the effect of combining adiposity indices (BMI/WC) with the gene expression of several biomarkers involved in breast cancer.
+
+ Methods: Expression of cytochrome P450 family 19 subfamily A member 1 (CYP19A1), estrogen receptor-alpha (ER-alpha), allograft inflammatory factor 1 (AIF1), cyclooxygenase-2 (COX2), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and leptin (LEP) in 141 adipose breast tissues was quantified using qPCR method. BMI and WC were measured by a trained nurse and categorized using the median split, BMILOWCLO, BMILOWCHI, BMIHIWCLO, and BMIHIWCHI.
+
+ Results: Gene expression of IL-6 (3-fold), TNF-alpha (2-fold), and LEP (2-fold) was higher in the breast adipose tissue of women with high WC regardless of BMI, that is, BMILOWCHI and BMIHIWCHI women (all P < 0.01). Compared to BMILOWCLO women, gene expression of CYP19A1, COX2, and AIF1 was increased by two-fold in breast adipose tissue of BMIHIWCHI women (P < 0.10). ER-alpha was not different across adiposity categories.
+
+ Conclusions: The expression of some biomarkers, particularly those related to inflammation, is elevated in breast adipose tissue of women with a high WC independent of BMI. Obesity monitoring should also include women with normal or low BMI, but with central adiposity. Copyright © 2021 Sue-Ling Chang et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f3620147
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chang&issn=2090-0708&title=Journal+of+Obesity&atitle=Associations+of+Biomarkers+of+Inflammation+and+Breast+Cancer+in+the+Breast+Adipose+Tissue+of+Women+with+Combined+Measures+of+Adiposity.&volume=2021&issue=&spage=3620147&epage=&date=2021&doi=10.1155%2F2021%2F3620147&pmid=34426770&sid=OVID:medline
+
+<771>
+Unique Identifier
+ 34422134
+Title
+ APOA-5 Genetic Variant rs662799: Role in Lipid Changes and Insulin Resistance after a Mediterranean Diet in Caucasian Obese Subjects.
+Source
+ Disease Markers. 2021:1257145, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Luis D; Izaola O; Primo D
+Author NameID
+ de Luis, Daniel; ORCID: https://orcid.org/0000-0002-1745-9315
+ Izaola, Olatz; ORCID: https://orcid.org/0000-0003-1201-4875
+ Primo, David; ORCID: https://orcid.org/0000-0002-3474-0766
+Authors Full Name
+ de Luis, Daniel; Izaola, Olatz; Primo, David.
+Institution
+ de Luis, Daniel. Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
+ Izaola, Olatz. Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
+ Primo, David. Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
+MeSH Subject Headings
+ Adult
+ *Apolipoprotein A-V/ge [Genetics]
+ Biomarkers/bl [Blood]
+ Diet, Mediterranean
+ Diet, Reducing
+ Female
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Resistance/ge [Genetics]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Obesity/ge [Genetics]
+ *Polymorphism, Single Nucleotide
+ Triglycerides/bl [Blood]
+ *White People/ge [Genetics]
+Abstract
+ BACKGROUND AND AIMS: This APOA5-1131C allele is related with a higher serum triglyceride levels and perhaps a different metabolic response to a dietary intervention. The aim of the present investigation was to evaluate SNP rs662799 in the APOA5 gene and its associations with metabolic effects after a hypocaloric diet with Mediterranean pattern.
+
+ METHODS: A population of 363 Caucasian obese patients was enrolled. Anthropometric parameters and serum parameters (lipid profile, insulin, homeostasis model assessment (HOMA-IR), glucose, C reactive protein, adiponectin, resistin, and leptin levels) were measured, at basal time and after 3 months. All patients were genotyped in the rs662799 polymorphism.
+
+ RESULTS: The APOA5 variant distribution was as follows: 89.3% (n = 324) (TT) were homozygous for the T allele, 10.5% (n = 38) (TC) were heterozygous, and 0.2% (n = 1) (CC) were homozygous for the C allele. Triglyceride levels were higher in patients with the C allele. After dietary intervention, BMI, weight, fat mass, waist circumference, systolic blood pressure, adiponectin, leptin, and adiponectin/leptin ratio improved significantly in both genotype groups TT and TC+CC. After dietary intervention, insulin levels (delta: -3.6 +/- 0.8 UI/L vs. -1.5 +/- 0.6 UI/L; P = 0.03), HOMA-IR (delta: -1.5 +/- 0.4 units vs. -0.3 +/- 0.2 units; P = 0.02), and triglyceride levels (delta: -19.3 +/- 4.2 mg/dL vs. -3.2 +/- 3.1 mg/dL; P = 0.02) decreased in non-C allele carriers.
+
+ CONCLUSIONS: C allele carriers of rs662799 of the APOA5 gene did not show an improvement in triglyceride, insulin, and HOMA-IR levels after a significant weight loss due to a hypocaloric diet with a Mediterranean pattern. Copyright © 2021 Daniel de Luis et al.
+Registry Number/Name of Substance
+ 0 (APOA5 protein, human). 0 (Apolipoprotein A-V). 0 (Biomarkers). 0 (Insulin). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f1257145
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Luis&issn=0278-0240&title=Disease+Markers&atitle=APOA-5+Genetic+Variant+rs662799%3A+Role+in+Lipid+Changes+and+Insulin+Resistance+after+a+Mediterranean+Diet+in+Caucasian+Obese+Subjects.&volume=2021&issue=&spage=1257145&epage=&date=2021&doi=10.1155%2F2021%2F1257145&pmid=34422134&sid=OVID:medline
+
+<772>
+Unique Identifier
+ 34421824
+Title
+ Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus.
+Source
+ Frontiers in Endocrinology. 12:706845, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hukportie DN; Li FR; Zhou R; Zheng JZ; Wu XX; Wu XB
+Authors Full Name
+ Hukportie, Daniel Nyarko; Li, Fu-Rong; Zhou, Rui; Zheng, Jia-Zhen; Wu, Xiao-Xiang; Wu, Xian-Bo.
+Institution
+ Hukportie, Daniel Nyarko. Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, China.
+ Li, Fu-Rong. Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, China.
+ Li, Fu-Rong. School of Medicine, Southern University of Science and Technology, Shenzhen, China.
+ Zhou, Rui. Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, China.
+ Zheng, Jia-Zhen. Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, China.
+ Wu, Xiao-Xiang. Department of General Surgery, 157th Hospital, General Hospital of Guangzhou Military Command, Guangzhou, China.
+ Wu, Xian-Bo. Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, China.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetic Nephropathies/ep [Epidemiology]
+ Diabetic Nephropathies/et [Etiology]
+ Diabetic Nephropathies/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Risk Factors
+ *Waist Circumference
+ *Waist-Height Ratio
+Keyword Heading
+ body mass index
+ diabetic nephropathy
+ obesity
+ waist circumference
+ waist-to-height ratio
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: The prevalence of diabetes is on the rise globally coupled with its associated complications, such as diabetic nephropathy (DN). Obesity has been identified as a risk factor for the development of DN but it is still unclear which obesity index is the best predictor of incident DN.
+
+ Methods: Data from the participants with type 2 diabetes mellitus (T2DM) in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study were used to examine the sex-specific association between waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) with incident DN risk.
+
+ Results: Among the 8,887 participants with T2DM (5,489 men and 3,398 women), 5,296 participants (3,345 men and 1,951 women) developed the DN composite outcome during a follow-up period of 24302 person-years. Among men, null associations were observed between all anthropometric measures with incident DN in the multivariate analysis although the 3rd quartile of WHtR showed marginally significant results (P = 0.052). However, among women, both central and general obesity measures were associated with increased risks of incident DN. Compared with participants in the WC <88 cm category, the fully adjusted HR and 95% CI for those in the >=88 cm of WC was 1.35 (95% CI 1.15-1.57). Compared with the lowest quartile, the fully adjusted HRs and 95% CIs for the 2nd to the 4th quartile of WHtR were 1.09 (95% CI 0.96-1.25), 1.12 (95% CI 0.98-1.28), and 1.14 (95% CI 1.00-1.30) respectively; also, compared with the normal BMI category, the fully adjusted HRs and 95% CIs for class I - class III obese were 1.36 (95% CI 1.10 - 1.67), 1.43 (95% CI 1.16 - 1.78) and 1.32 (95% CI 1.05 - 1.66) respectively.
+
+ Conclusions: Among participants with T2DM, higher levels of both central and general obesity indexes were associated with DN risk among women but not in men. Women with T2DM should maintain a healthy weight targeted at reducing both central and general obesity to enhance nephroprotection. Trial registration: ClinicalTrials.gov., no. NCT00000620. Copyright © 2021 Hukportie, Li, Zhou, Zheng, Wu and Wu.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.706845
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hukportie&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Anthropometric+Measures+and+Incident+Diabetic+Nephropathy+in+Participants+With+Type+2+Diabetes+Mellitus.&volume=12&issue=&spage=706845&epage=&date=2021&doi=10.3389%2Ffendo.2021.706845&pmid=34421824&sid=OVID:medline
+
+<773>
+Unique Identifier
+ 34420816
+Title
+ Acute and long-term effects of saxagliptin on a set of cardiovascular targets measured at fasting and post-prandially in obese patients with impaired glucose tolerance: A placebo-controlled study.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(10):2945-2958, 2021 09 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rezki A; Cosson E; Fysekidis M; Chiheb S; Vicaut E; Valensi P
+Authors Full Name
+ Rezki, Amel; Cosson, Emmanuel; Fysekidis, Marinos; Chiheb, Sabrina; Vicaut, Eric; Valensi, Paul.
+Institution
+ Rezki, Amel. AP-HP, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, CINFO, Paris 13 University, Jean Verdier Hospital, Bondy, France; Paris 13 University, Sorbonne Paris Cite, UMR U557 INSERM/U11125 INRA/CNAM/Universite Paris13, Unite de Recherche Epidemiologique Nutritionnelle, Bobigny, France.
+ Cosson, Emmanuel. AP-HP, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, CINFO, Paris 13 University, Jean Verdier Hospital, Bondy, France; Paris 13 University, Sorbonne Paris Cite, UMR U557 INSERM/U11125 INRA/CNAM/Universite Paris13, Unite de Recherche Epidemiologique Nutritionnelle, Bobigny, France.
+ Fysekidis, Marinos. AP-HP, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, CINFO, Paris 13 University, Jean Verdier Hospital, Bondy, France; Paris 13 University, Sorbonne Paris Cite, UMR U557 INSERM/U11125 INRA/CNAM/Universite Paris13, Unite de Recherche Epidemiologique Nutritionnelle, Bobigny, France.
+ Chiheb, Sabrina. AP-HP, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, CINFO, Paris 13 University, Jean Verdier Hospital, Bondy, France.
+ Vicaut, Eric. Universite Denis Diderot, AP-HP Unite de Recherche Clinique St-Louis-Lariboisiere, Paris, France.
+ Valensi, Paul. AP-HP, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, CINFO, Paris 13 University, Jean Verdier Hospital, Bondy, France. Electronic address: paul.valensi@aphp.fr.
+MeSH Subject Headings
+ Adamantane/ae [Adverse Effects]
+ *Adamantane/aa [Analogs & Derivatives]
+ Adamantane/tu [Therapeutic Use]
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Cardiovascular System/de [Drug Effects]
+ Cardiovascular System/ir [Innervation]
+ Cardiovascular System/pp [Physiopathology]
+ Dipeptides/ae [Adverse Effects]
+ *Dipeptides/tu [Therapeutic Use]
+ Dipeptidyl-Peptidase IV Inhibitors/ae [Adverse Effects]
+ *Dipeptidyl-Peptidase IV Inhibitors/tu [Therapeutic Use]
+ Double-Blind Method
+ Female
+ France
+ Glucose Intolerance/bl [Blood]
+ Glucose Intolerance/co [Complications]
+ *Glucose Intolerance/dt [Drug Therapy]
+ Glucose Intolerance/pp [Physiopathology]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Pilot Projects
+ *Postprandial Period
+ Time Factors
+ Treatment Outcome
+ Vagus Nerve/de [Drug Effects]
+ Vagus Nerve/pp [Physiopathology]
+Keyword Heading
+ Arterial stiffness
+ Autonomic nervous system
+ Dipeptidyl peptidase inhibitor
+ Endothelium
+ Impaired glucose tolerance
+ Microcirculation
+ Post-prandial
+ Saxagliptin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Studies of dipeptidyl peptidase inhibitors (DPP4is) report heterogeneous effects on cardiovascular targets in type 2 diabetes. This study aimed to investigate, in patients with impaired glucose tolerance (IGT), whether saxagliptin, a DPP4i, had beneficial cardiovascular effects at fasting and during the post-prandial state.
+
+ METHODS AND RESULTS: In this randomized, placebo-controlled, double-blind, single-center pilot exploratory study, we included obese individuals with IGT. Twenty-four individuals (BMI 36.8 +/- 4.8 kg/m2) were randomized to receive for 12 weeks either saxagliptin 5 mg a day or placebo. They were explored before and after a standardized breakfast for biological markers; microcirculatory blood flow at baseline and after transcutaneous administration of acetylcholine (Periflux System 5000 R PERIMED); post-occlusive digital reactive hyperhemia (Endopat2000 R); pulse wave velocity, augmentation index, central pulse pressure and subendocardial viability ratio (Sphygmocor R); cardiac hemodynamic parameters and cardiovascular autonomic nervous system activity (Task force monitor R). The results of all the investigations were similar after breakfast in the two groups at Visit 1 (acute post-prandial effects, after the first tablet) and Visit 2 (long-term post-prandial effects), and at fasting at Visit 1 and 2 (long-term effects, after 12 weeks of treatment). Only at Visit 2 the decrease in cardiac vagal activity occurring after breakfast was more sustained in the saxagliptin group than in the placebo group (interaction between treatment and time effect: p = 0.016).
+
+ CONCLUSION: In obese patients with IGT, the effects of saxagliptin on the large set of cardiovascular parameters measured are neutral, except for a more marked post-prandial depression of vagal activity.
+
+ CLINICAL TRIAL REGISTRATION NUMBER: NCT01521312. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dipeptides). 0 (Dipeptidyl-Peptidase IV Inhibitors). 9GB927LAJW (saxagliptin). PJY633525U (Adamantane).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.06.017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rezki&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Acute+and+long-term+effects+of+saxagliptin+on+a+set+of+cardiovascular+targets+measured+at+fasting+and+post-prandially+in+obese+patients+with+impaired+glucose+tolerance%3A+A+placebo-controlled+study.&volume=31&issue=10&spage=2945&epage=2958&date=2021&doi=10.1016%2Fj.numecd.2021.06.017&pmid=34420816&sid=OVID:medline
+
+<774>
+Unique Identifier
+ 34419146
+Title
+ Dynamic co-expression modular network analysis in nonalcoholic fatty liver disease.
+Source
+ Hereditas. 158(1):31, 2021 Aug 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zheng J; Wu H; Zhang Z; Yao S
+Authors Full Name
+ Zheng, Jing; Wu, Huizhong; Zhang, Zhiying; Yao, Songqiang.
+Institution
+ Zheng, Jing. Department of Pharmacy, Zhejiang Medical & Health Group Hangzhou Hospital, No.1 Banshan Road, Kangjian nong, Hangzhou, 310022, China.
+ Wu, Huizhong. Department of Pharmacy, Zhejiang Quhua Hospital, Quzhou, 324002, China.
+ Zhang, Zhiying. Department of Pharmacy, Hangzhou Jianggan District People's Hospital, Hangzhou, 310016, China.
+ Yao, Songqiang. Department of Pharmacy, Zhejiang Medical & Health Group Hangzhou Hospital, No.1 Banshan Road, Kangjian nong, Hangzhou, 310022, China. songqiangyao888@163.com.
+MeSH Subject Headings
+ Biomarkers
+ Female
+ *Gene Regulatory Networks
+ Humans
+ Male
+ Metabolic Syndrome/ge [Genetics]
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ Obesity/ge [Genetics]
+ Oligonucleotide Array Sequence Analysis
+Keyword Heading
+ Fatty liver
+ Gene regulatory network
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease affecting people's health worldwide. Exploring the potential biomarkers and dynamic networks during NAFLD progression is urgently important.
+
+ MATERIAL AND METHODS: Differentially expressed genes (DEGs) in obesity, NAFL and NASH were screened from GSE126848 and GSE130970, respectively. Gene set enrichment analysis of DEGs was conducted to reveal the Gene Ontology (GO) biological process in each period. Dynamic molecular networks were constructed by DyNet to illustrate the common and distinct progression of health- or obesity-derived NAFLD. The dynamic co-expression modular analysis was carried out by CEMiTool to elucidate the key modulators, networks, and enriched pathways during NAFLD.
+
+ RESULTS: A total of 453 DEGs were filtered from obesity, NAFL and NASH periods. Function annotation showed that health-NAFLD sequence was mainly associated with dysfunction of metabolic syndrome pathways, while obesity-NAFLD sequence exhibited dysregulation of Cell cycle and Cellular senescence pathways. Nine nodes including COL3A1, CXCL9, CYCS, CXCL10, THY1, COL1A2, SAA1, CDKN1A, and JUN in the dynamic networks were commonly identified in health- and obesity-derived NAFLD. Moreover, CYCS, whose role is unknown in NAFLD, possessed the highest correlation with NAFLD activity score, lobular inflammation grade, and the cytological ballooning grade. Dynamic co-expression modular analysis showed that module 4 was activated in NAFL and NASH, while module 3 was inhibited at NAFLD stages. Module 3 was negatively correlated with CXCL10, and module 4 was positively correlated with COL1A2 and THY1.
+
+ CONCLUSION: Dynamic network analysis and dynamic gene co-expression modular analysis identified a nine-gene signature as the potential key regulator in NAFLD progression, which provided comprehensive regulatory mechanisms underlying NAFLD progression. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs41065-021-00196-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zheng&issn=0018-0661&title=Hereditas&atitle=Dynamic+co-expression+modular+network+analysis+in+nonalcoholic+fatty+liver+disease.&volume=158&issue=1&spage=31&epage=&date=2021&doi=10.1186%2Fs41065-021-00196-8&pmid=34419146&sid=OVID:medline
+
+<775>
+Unique Identifier
+ 34418300
+Title
+ Impaired immunomodulatory capacity in adipose tissue-derived mesenchymal stem/stromal cells isolated from obese patients.
+Source
+ Journal of Cellular & Molecular Medicine. 25(18):9051-9059, 2021 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhu XY; Klomjit N; Conley SM; Ostlie MM; Jordan KL; Lerman A; Lerman LO
+Author NameID
+ Lerman, Lilach O; ORCID: https://orcid.org/0000-0002-3271-3887
+Authors Full Name
+ Zhu, Xiang-Yang; Klomjit, Nattawat; Conley, Sabena M; Ostlie, Megan M; Jordan, Kyra L; Lerman, Amir; Lerman, Lilach O.
+Institution
+ Zhu, Xiang-Yang. Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, USA.
+ Klomjit, Nattawat. Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, USA.
+ Conley, Sabena M. Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, USA.
+ Ostlie, Megan M. Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, USA.
+ Jordan, Kyra L. Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, USA.
+ Lerman, Amir. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
+ Lerman, Lilach O. Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, USA.
+ Lerman, Lilach O. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Animals
+ *Biomarkers/an [Analysis]
+ Cells, Cultured
+ Female
+ Humans
+ Macrophages/im [Immunology]
+ Macrophages/pa [Pathology]
+ *Macrophages
+ Male
+ Mesenchymal Stem Cells/im [Immunology]
+ Mesenchymal Stem Cells/pa [Pathology]
+ *Mesenchymal Stem Cells
+ Mice
+ Middle Aged
+ *Obesity/im [Immunology]
+ Young Adult
+Keyword Heading
+ inflammation
+ macrophage
+ mesenchymal stem cells
+ renal artery stenosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Immune-modulatory properties of adipose tissue-derived mesenchymal stem/stromal cells (MSCs) might be susceptible to metabolic disturbances. We hypothesized that the immune-modulatory function of MSCs might be blunted in obese human subjects. MSCs were collected from abdominal subcutaneous fat of obese and lean subjects during bariatric or kidney donation surgeries, respectively. MSCs were co-cultured in vitro for 24 h with M1 macrophages, which were determined as M1or M2 phenotypes by flow cytometry, and cytokines measured in conditioned media. In vivo, lean or obese MSCs (5 x 105 ), or PBS, were injected into mice two weeks after unilateral renal artery stenosis (RAS) or sham surgeries (n = 6 each). Fourteen days later, kidneys were harvested and stained with M1 or M2 markers. Lean MSCs decreased macrophages M1 marker intensity, which remained elevated in macrophages co-cultured with obese MSCs. TNF-alpha levels were four-fold higher in conditioned media collected from obese than from lean MSCs. RAS mouse kidneys were shrunk and showed increased M1 macrophage numbers and inflammatory cytokine expression compared with normal kidneys. Lean MSCs decreased M1 macrophages, M1/M2 ratio and inflammation in RAS kidneys, whereas obese MSCs did not. MSCs isolated from lean human subjects decrease inflammatory M1 macrophages both in vivo and in vitro, an immune-modulatory function which is blunted in MSCs isolated from obese subjects. Copyright © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1111%2fjcmm.16869
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhu&issn=1582-1838&title=Journal+of+Cellular+%26+Molecular+Medicine&atitle=Impaired+immunomodulatory+capacity+in+adipose+tissue-derived+mesenchymal+stem%2Fstromal+cells+isolated+from+obese+patients.&volume=25&issue=18&spage=9051&epage=9059&date=2021&doi=10.1111%2Fjcmm.16869&pmid=34418300&sid=OVID:medline
+
+<776>
+Unique Identifier
+ 34403503
+Title
+ IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
+Source
+ Immunology. 164(4):817-833, 2021 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hsu YH; Wu CH; Chiu CJ; Chen WT; Chang YC; Wabitsch M; Chang MS
+Author NameID
+ Hsu, Yu-Hsiang; ORCID: https://orcid.org/0000-0003-2738-2638
+ Chang, Ming-Shi; ORCID: https://orcid.org/0000-0001-9577-0400
+Authors Full Name
+ Hsu, Yu-Hsiang; Wu, Chih-Hsing; Chiu, Chiao-Juno; Chen, Wei-Ting; Chang, Yi-Chieh; Wabitsch, Martin; Chang, Ming-Shi.
+Institution
+ Hsu, Yu-Hsiang. Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
+ Hsu, Yu-Hsiang. Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
+ Wu, Chih-Hsing. Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
+ Chiu, Chiao-Juno. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
+ Chen, Wei-Ting. Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
+ Chang, Yi-Chieh. Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
+ Wabitsch, Martin. Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
+ Chang, Ming-Shi. Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipogenesis/ge [Genetics]
+ *Adipogenesis
+ Adult
+ Aged
+ Aged, 80 and over
+ Animals
+ Biomarkers
+ Chemotaxis, Leukocyte
+ Cytokines/me [Metabolism]
+ Disease Models, Animal
+ *Disease Susceptibility
+ Female
+ Gene Expression
+ Glucose/me [Metabolism]
+ Humans
+ Insulin/me [Metabolism]
+ Interleukins/ge [Genetics]
+ *Interleukins/me [Metabolism]
+ Macrophages/im [Immunology]
+ *Macrophages/me [Metabolism]
+ Male
+ Mice
+ Middle Aged
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Signal Transduction
+Keyword Heading
+ cytokines
+ inflammation
+ insulin resistance
+ interleukin 20
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ IL-20 is a proinflammatory cytokine of the IL-10 family and involved in several diseases. However, the regulatory role of IL-20 in obesity is not well understood. We explored the function of IL-20 in the pathogenesis of obesity-induced insulin resistance by ELISA, Western blotting and flow cytometry. The therapeutic potential of IL-20 monoclonal antibody 7E for ameliorating diet-induced obesity was analysed in murine models. Higher serum IL-20 levels were detected in obese patients. It was upregulated in leptin-deficient (ob/ob), leptin-resistant (db/db) and high-fat diet (HFD)-induced murine obesity models. In vitro, IL-20 regulated the adipocyte differentiation and the polarization of bone marrow-derived macrophages into proinflammatory M1 type. It also caused inflammation and macrophage retention in adipose tissues by upregulating TNF-alpha, monocyte chemotactic protein 1 (MCP-1), netrin 1 and unc5b (netrin receptor) expression in macrophages and netrin 1, leptin and MCP-1 in adipocytes. IL-20 promoted insulin resistance by inhibiting glucose uptake in mature adipocytes through the SOCS-3 pathway. In HFD-induced obesity in mice, 7E treatment reduced body weight and improved glucose tolerance and insulin sensitivity; it also reduced local inflammation and the number of M1-like macrophages in adipose tissues. We have identified a critical role of IL-20 in obesity-induced inflammation and insulin resistance, and we conclude that IL-20 may be a novel target for treating obesity and insulin resistance in patients with metabolic disorders. Copyright © 2021 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Insulin). 0 (Interleukins). IY9XDZ35W2 (Glucose). U91R7IMG8U (interleukin 20).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1111%2fimm.13403
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hsu&issn=0019-2805&title=Immunology&atitle=IL-20+is+involved+in+obesity+by+modulation+of+adipogenesis+and+macrophage+dysregulation.&volume=164&issue=4&spage=817&epage=833&date=2021&doi=10.1111%2Fimm.13403&pmid=34403503&sid=OVID:medline
+
+<777>
+Unique Identifier
+ 34403358
+Title
+ Molecular diagnosis of polycystic ovary syndrome in obese and non-obese women by targeted plasma miRNA profiling.
+Source
+ European Journal of Endocrinology. 185(5):637-652, 2021 Oct 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Romero-Ruiz A; Pineda B; Ovelleiro D; Perdices-Lopez C; Torres E; Vazquez MJ; Guler I; Jimenez A; Pineda R; Persano M; Romero-Baldonado C; Arjona JE; Lorente J; Munoz C; Paz E; Garcia-Maceira FI; Arjona-Sanchez A; Tena-Sempere M
+Authors Full Name
+ Romero-Ruiz, Antonio; Pineda, Beatriz; Ovelleiro, David; Perdices-Lopez, Cecilia; Torres, Encarnacion; Vazquez, Maria J; Guler, Ipek; Jimenez, Alvaro; Pineda, Rafael; Persano, Mariasara; Romero-Baldonado, Cristina; Arjona, Jose E; Lorente, Juan; Munoz, Concepcion; Paz, Elier; Garcia-Maceira, Fe-Isabel; Arjona-Sanchez, Alvaro; Tena-Sempere, Manuel.
+Institution
+ Romero-Ruiz, Antonio. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Romero-Ruiz, Antonio. Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.
+ Romero-Ruiz, Antonio. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Pineda, Beatriz. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Pineda, Beatriz. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Ovelleiro, David. Area of Cellular Biology, Department of Experimental Biology, University of Jaen, Jaen, Spain.
+ Perdices-Lopez, Cecilia. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Perdices-Lopez, Cecilia. Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.
+ Perdices-Lopez, Cecilia. CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Cordoba, Spain.
+ Torres, Encarnacion. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Torres, Encarnacion. Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.
+ Torres, Encarnacion. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Vazquez, Maria J. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Vazquez, Maria J. Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.
+ Vazquez, Maria J. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Guler, Ipek. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Jimenez, Alvaro. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Pineda, Rafael. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Pineda, Rafael. Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.
+ Persano, Mariasara. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Persano, Mariasara. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Romero-Baldonado, Cristina. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Arjona, Jose E. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Lorente, Juan. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Munoz, Concepcion. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Munoz, Concepcion. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Paz, Elier. Canvax Biotech, Cordoba, Spain.
+ Garcia-Maceira, Fe-Isabel. Canvax Biotech, Cordoba, Spain.
+ Arjona-Sanchez, Alvaro. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Arjona-Sanchez, Alvaro. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Tena-Sempere, Manuel. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Spain.
+ Tena-Sempere, Manuel. Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.
+ Tena-Sempere, Manuel. Hospital Universitario Reina Sofia, Cordoba, Spain.
+ Tena-Sempere, Manuel. CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Cordoba, Spain.
+ Tena-Sempere, Manuel. Institute of Biomedicine, University of Turku, Turku, Finland.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Algorithms
+ Biomarkers
+ Case-Control Studies
+ Cohort Studies
+ Computational Biology
+ Cross-Sectional Studies
+ Decision Trees
+ Female
+ *Gene Expression Profiling/mt [Methods]
+ High-Throughput Screening Assays
+ Humans
+ *MicroRNAs/bl [Blood]
+ *MicroRNAs/ge [Genetics]
+ *Obesity/et [Etiology]
+ *Obesity/ge [Genetics]
+ *Polycystic Ovary Syndrome/co [Complications]
+ *Polycystic Ovary Syndrome/ge [Genetics]
+ Reproducibility of Results
+ Young Adult
+Abstract
+ OBJECTIVE: Polycystic ovary syndrome (PCOS) is diagnosed based on the clinical signs, but its presentation is heterogeneous and potentially confounded by concurrent conditions, such as obesity and insulin resistance. miRNA have recently emerged as putative pathophysiological and diagnostic factors in PCOS. However, no reliable miRNA-based method for molecular diagnosis of PCOS has been reported. The aim of this study was to develop a tool for accurate diagnosis of PCOS by targeted miRNA profiling of plasma samples, defined on the basis of unbiased biomarker-finding analyses and biostatistical tools.
+
+ METHODS: A case-control PCOS cohort was cross-sectionally studied, including 170 women classified into four groups: non-PCOS/lean, non-PCOS/obese, PCOS/lean, and PCOS/obese women. High-throughput miRNA analyses were performed in plasma, using NanoString technology and a 800 human miRNA panel, followed by targeted quantitative real-timePCR validation. Statistics were applied to define optimal normalization methods, identify deregulated biomarker miRNAs, and build classification algorithms, considering PCOS and obesity as major categories.
+
+ RESULTS: The geometric mean of circulating hsa-miR-103a-3p, hsa-miR-125a-5p, and hsa-miR-1976, selected among 125 unchanged miRNAs, was defined as optimal reference for internal normalization (named mR3-method). Ten miRNAs were identified and validated after mR3-normalization as differentially expressed across the groups. Multinomial least absolute shrinkage and selection operator regression and decision-tree models were built to reliably discriminate PCOS vs non-PCOS, either in obese or non-obese women, using subsets of these miRNAs as performers.
+
+ CONCLUSIONS: We define herein a robust method for molecular classification of PCOS based on unbiased identification of miRNA biomarkers and decision-tree protocols. This method allows not only reliable diagnosis of non-obese women with PCOS but also discrimination between PCOS and obesity.
+
+ CAPSULE: We define a novel protocol, based on plasma miRNA profiling, for molecular diagnosis of PCOS. This tool not only allows proper discrimination of the condition in non-obese women but also permits distinction between PCOS and obesity, which often display overlapping clinical presentations.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1530%2fEJE-21-0552
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Romero-Ruiz&issn=0804-4643&title=European+Journal+of+Endocrinology&atitle=Molecular+diagnosis+of+polycystic+ovary+syndrome+in+obese+and+non-obese+women+by+targeted+plasma+miRNA+profiling.&volume=185&issue=5&spage=637&epage=652&date=2021&doi=10.1530%2FEJE-21-0552&pmid=34403358&sid=OVID:medline
+
+<778>
+Unique Identifier
+ 34403036
+Title
+ Transforming growth factor beta 1 (TGFbeta1) plasmatic levels and haplotype structures in obesity: a role for TGFbeta1 in steatosis development.
+Source
+ Molecular Biology Reports. 48(9):6401-6411, 2021 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Felicidade I; Bocchi M; Ramos MRZ; Carlos LO; Wagner NRF; Campos ACL; Ribeiro LR; Mantovani MS; Watanabe MAE; Vitiello GAF
+Authors Full Name
+ Felicidade, Ingrid; Bocchi, Mayara; Ramos, Marilia Rizzon Zaparolli; Carlos, Ligia de Oliveira; Wagner, Nathalia Ramori Farinha; Campos, Antonio Carlos Ligocki; Ribeiro, Lucia Regina; Mantovani, Mario Sergio; Watanabe, Maria Angelica Ehara; Vitiello, Glauco Akelinghton Freire.
+Institution
+ Felicidade, Ingrid. Department of General Biology, Biological Sciences Center, Londrina State University (UEL), Londrina, PR, Brazil.
+ Felicidade, Ingrid. School of Medicine, Department of Pathology, Sao Paulo State University (UNESP), Sao Paulo, SP, Brazil.
+ Bocchi, Mayara. Department of Pathological Sciences, Biological Sciences Center, Londrina State University (UEL), Londrina, PR, Brazil.
+ Ramos, Marilia Rizzon Zaparolli. Clinical Surgery Department, Federal University of Parana (UFPR), Curitiba, PR, Brazil.
+ Carlos, Ligia de Oliveira. Clinical Surgery Department, Federal University of Parana (UFPR), Curitiba, PR, Brazil.
+ Wagner, Nathalia Ramori Farinha. Clinical Surgery Department, Federal University of Parana (UFPR), Curitiba, PR, Brazil.
+ Campos, Antonio Carlos Ligocki. Clinical Surgery Department, Federal University of Parana (UFPR), Curitiba, PR, Brazil.
+ Ribeiro, Lucia Regina. School of Medicine, Department of Pathology, Sao Paulo State University (UNESP), Sao Paulo, SP, Brazil.
+ Mantovani, Mario Sergio. Department of General Biology, Biological Sciences Center, Londrina State University (UEL), Londrina, PR, Brazil.
+ Watanabe, Maria Angelica Ehara. Department of Pathological Sciences, Biological Sciences Center, Londrina State University (UEL), Londrina, PR, Brazil.
+ Vitiello, Glauco Akelinghton Freire. Department of Pathological Sciences, Biological Sciences Center, Londrina State University (UEL), Londrina, PR, Brazil. gvitiello@uel.br.
+ Vitiello, Glauco Akelinghton Freire. Laboratory of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, PR445, Km 380 Celso Garcia Cid highway, Londrina, PR, 86057-970, Brazil. gvitiello@uel.br.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ *Fatty Liver/bl [Blood]
+ *Fatty Liver/co [Complications]
+ Fatty Liver/ge [Genetics]
+ Female
+ Genetic Predisposition to Disease
+ *Haplotypes
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Polymerase Chain Reaction/mt [Methods]
+ Polymorphism, Restriction Fragment Length
+ Polymorphism, Single Nucleotide
+ Promoter Regions, Genetic/ge [Genetics]
+ *Transforming Growth Factor beta1/bl [Blood]
+ *Transforming Growth Factor beta1/ge [Genetics]
+ Young Adult
+Keyword Heading
+ Inflammation
+ Obesity
+ Overweight
+ Steatosis
+ Transforming growth factor beta
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is considered a chronic inflammatory disease and transforming growth factor beta 1 (TGFbeta1) might exert important roles in disease pathogenesis regulating adipocyte differentiation and immune-inflammatory environment. However, the role of this cytokine as a biomarker in obesity is poorly addressed. Therefore, the present study aimed to evaluate the impact of TGFB1 polymorphisms and TGFbeta1 plasmatic levels in obesity METHODS AND RESULTS: TGFB1 promoter region polymorphisms (rs1800468, G-800A and rs1800469, C-509 T) were evaluated in 75 obese patients and 45 eutrophic patients through PCR-RFLP and plasmatic TGFbeta1 was quantified through ELISA from 37 of the obese patients, and correlations with clinical and biochemical parameters were tested. Despite no association was found between TGFB1 polymorphisms and obesity susceptibility, several correlations with clinical data were noted. Among others, AC haplotype negatively correlated with plasmatic TGFbeta1, while plasmatic TGFbeta1 negatively correlated with C-reactive protein and positively correlated with liver abnormalities on ultrasound and, specifically, with steatosis presence and degree. Conversely, GT haplotype, which associates with higher TGFbeta1 production, was also positively correlated with the same parameters of liver abnormalities. Further, plasmatic vitamin D negatively correlated with TGFbeta1, while positively correlated with AC haplotype.
+
+ CONCLUSION: Overall, the results indicate that TGFbeta1 might exert important roles in obesity pathophysiology and correlate with biochemical and clinical parameters both at systemic protein as well as at genetic level. Importantly, the consistent positive correlation at both levels with steatosis might suggest this cytokine as a biomarker for this hepatic abnormality in obese patients. Copyright © 2021. The Author(s), under exclusive licence to Springer Nature B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (TGFB1 protein, human). 0 (Transforming Growth Factor beta1). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs11033-021-06640-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Felicidade&issn=0301-4851&title=Molecular+Biology+Reports&atitle=Transforming+growth+factor+beta+1+%28TGFbeta1%29+plasmatic+levels+and+haplotype+structures+in+obesity%3A+a+role+for+TGFbeta1+in+steatosis+development.&volume=48&issue=9&spage=6401&epage=6411&date=2021&doi=10.1007%2Fs11033-021-06640-2&pmid=34403036&sid=OVID:medline
+
+<779>
+Unique Identifier
+ 34395631
+Title
+ The Problem of Abnormal Body Weight and Dyslipidemia as Risk Factors for Cardiovascular Diseases in Children and Adolescents with Type 1 Diabetes. [Review]
+Source
+ Journal of Diabetes Research. 2021:5555149, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Noras K; Rusak E; Jarosz-Chobot P
+Author NameID
+ Rusak, Ewa; ORCID: https://orcid.org/0000-0002-4422-7704
+Authors Full Name
+ Noras, Katarzyna; Rusak, Ewa; Jarosz-Chobot, Przemyslawa.
+Institution
+ Noras, Katarzyna. Department of Children's Diabetology, Upper Silesian Child Health Centre, Katowice, Poland.
+ Rusak, Ewa. Department of Children's Diabetology, Medical University of Silesia, Katowice, Poland.
+ Jarosz-Chobot, Przemyslawa. Department of Children's Diabetology, Medical University of Silesia, Katowice, Poland.
+MeSH Subject Headings
+ Adolescent
+ Age Factors
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Weight
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Child
+ Diabetes Mellitus, Type 1/bl [Blood]
+ Diabetes Mellitus, Type 1/di [Diagnosis]
+ *Diabetes Mellitus, Type 1/ep [Epidemiology]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ *Dyslipidemias/ep [Epidemiology]
+ Humans
+ Lipids/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+Abstract
+ Diabetes is a disease that affects many people around the world. Its complications are the cause of cardiovascular diseases (CVD) and increased mortality. That is why the search for predictive biomarkers is so important. The aim of the study was to show the prevalence of the problem and risk factors in children and adolescents with type 1 diabetes. These patients are often overweight and obese, and the percentage of lipid disorders is particularly high. The discussed markers of CVD risk in type 1 diabetes include apolipoproteins (apo-B and apo-C3), modified forms of LDL, and the role of high-density lipoprotein (HDL). Recently, a new look at the vasoprotective effect of HDL has appeared, which due to its dysfunctional form in type 1 diabetes may not protect against cardiovascular risk. The HDL proteome in type 1 diabetes has an altered protein composition compared to the healthy population. Another direction of research is determining the importance of trace elements (mainly Mg) in the development of diabetes complications. Copyright © 2021 Katarzyna Noras et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f5555149
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Noras&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=The+Problem+of+Abnormal+Body+Weight+and+Dyslipidemia+as+Risk+Factors+for+Cardiovascular+Diseases+in+Children+and+Adolescents+with+Type+1+Diabetes.&volume=2021&issue=&spage=5555149&epage=&date=2021&doi=10.1155%2F2021%2F5555149&pmid=34395631&sid=OVID:medline
+
+<780>
+Unique Identifier
+ 34394118
+Title
+ Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity.
+Source
+ Frontiers in Immunology. 12:713989, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mondanelli G; Albini E; Orecchini E; Pallotta MT; Belladonna ML; Ricci G; Grohmann U; Orabona C
+Authors Full Name
+ Mondanelli, Giada; Albini, Elisa; Orecchini, Elena; Pallotta, Maria Teresa; Belladonna, Maria Laura; Ricci, Giovanni; Grohmann, Ursula; Orabona, Ciriana.
+Institution
+ Mondanelli, Giada. Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
+ Albini, Elisa. Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
+ Orecchini, Elena. Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
+ Pallotta, Maria Teresa. Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
+ Belladonna, Maria Laura. Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
+ Ricci, Giovanni. Service Center for Pre-clinical Research, University of Perugia, Perugia, Italy.
+ Grohmann, Ursula. Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
+ Orabona, Ciriana. Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Cytokines/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ *Disease Susceptibility
+ *Energy Metabolism
+ Hepatocytes/me [Metabolism]
+ Indoleamine-Pyrrole 2,3,-Dioxygenase/me [Metabolism]
+ Insulin/me [Metabolism]
+ *Interleukin-6/me [Metabolism]
+ Kynurenine/me [Metabolism]
+ Male
+ Mice
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Receptors, Interleukin-6/me [Metabolism]
+ *Tryptophan/me [Metabolism]
+Keyword Heading
+ IL-6 receptor (IL-6R)
+ experimental obesity
+ high fat diet (HFD)
+ indoleamine 2, 3 dioxygenase 1 (IDO1)
+ tocilizumab (TCZ)
+ tryptophan metabolism
+ white adipose tissue (WAT)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a metabolic disease characterized by a state of chronic, low-grade inflammation and dominated by pro-inflammatory cytokines such as IL-6. Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that catalyzes the first step in the kynurenine pathway by transforming l-tryptophan (Trp) into l-kynurenine (Kyn), a metabolite endowed with anti-inflammatory and immunoregulatory effects. In dendritic cells, IL-6 induces IDO1 proteasomal degradation and shuts down IDO1-mediated immunosuppressive effects. In tumor cells, IL-6 upregulates IDO1 expression and favors tumor immune escape mechanisms. To investigate the role of IDO1 and its possible relationship with IL-6 in obesity, we induced the disease by feeding mice with a high fat diet (HFD). Mice on a standard diet were used as control. Experimental obesity was associated with high IDO1 expression and Kyn levels in the stromal vascular fraction of visceral white adipose tissue (SVF WAT). IDO1-deficient mice on HFD gained less weight and were less insulin resistant as compared to wild type counterparts. Administration of tocilizumab (TCZ), an IL-6 receptor (IL-6R) antagonist, to mice on HFD significantly reduced weight gain, controlled adipose tissue hypertrophy, increased insulin sensitivity, and induced a better glucose tolerance. TCZ also induced a dramatic inhibition of IDO1 expression and Kyn production in the SVF WAT. Thus our data indicated that the IL-6/IDO1 axis may play a pathogenetic role in a chronic, low-grade inflammation condition, and, perhaps most importantly, IL-6R blockade may be considered a valid option for obesity treatment. Copyright © 2021 Mondanelli, Albini, Orecchini, Pallotta, Belladonna, Ricci, Grohmann and Orabona.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase). 0 (Insulin). 0 (Interleukin-6). 0 (Receptors, Interleukin-6). 343-65-7 (Kynurenine). 8DUH1N11BX (Tryptophan).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffimmu.2021.713989
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mondanelli&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Pathogenetic+Interplay+Between+IL-6+and+Tryptophan+Metabolism+in+an+Experimental+Model+of+Obesity.&volume=12&issue=&spage=713989&epage=&date=2021&doi=10.3389%2Ffimmu.2021.713989&pmid=34394118&sid=OVID:medline
+
+<781>
+Unique Identifier
+ 34393997
+Title
+ Exploratory Analysis in the Differences in Blood Serum and Seminal Plasma of Adipose-Tissue Related Peptides in Obese and Non-Obese Men and Their Correlations With Semen Parameters.
+Source
+ Frontiers in Endocrinology. 12:681939, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Antinozzi C; Lista M; Caponecchia L; Salacone P; Minganti C; Battaglia FA; Di Luigi L; Sgro P
+Authors Full Name
+ Antinozzi, Cristina; Lista, Marco; Caponecchia, Luisa; Salacone, Pietro; Minganti, Carlo; Battaglia, Francesco A; Di Luigi, Luigi; Sgro, Paolo.
+Institution
+ Antinozzi, Cristina. Unit of Endocrinology, Department of Movement, Human and Health Science, University of Rome "Foro Italico", Rome, Italy.
+ Lista, Marco. Unit of Endocrinology, Department of Movement, Human and Health Science, University of Rome "Foro Italico", Rome, Italy.
+ Caponecchia, Luisa. Andrology and Pathophysiology of Reproduction Unit, Santa Maria Goretti Hospital, Latina, Italy.
+ Salacone, Pietro. Andrology and Pathophysiology of Reproduction Unit, Santa Maria Goretti Hospital, Latina, Italy.
+ Minganti, Carlo. Unit of Sport Medicine, Department of Movement, Human and Health Science, University of Rome "Foro Italico", Rome, Italy.
+ Battaglia, Francesco A. Obstetric and Gynecology Unit, Santa Maria Goretti Hospital, Latina, Italy.
+ Di Luigi, Luigi. Unit of Endocrinology, Department of Movement, Human and Health Science, University of Rome "Foro Italico", Rome, Italy.
+ Sgro, Paolo. Unit of Endocrinology, Department of Movement, Human and Health Science, University of Rome "Foro Italico", Rome, Italy.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adult
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Hormones/bl [Blood]
+ *Hormones/me [Metabolism]
+ Humans
+ Male
+ Middle Aged
+ Nicotinamide Phosphoribosyltransferase/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ Peptides/bl [Blood]
+ *Peptides/me [Metabolism]
+ *Semen/me [Metabolism]
+Keyword Heading
+ adipokines
+ incretins
+ male reproduction
+ obesity
+ sex hormones
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objectives: Evaluating the relationship between circulating metabolic biomarkers and semen parameters in obese, overweight and normal-weight patients.
+
+ Methods: Patients were recruited at the "Andrology and Pathophysiology of Reproduction Unit", in Santa Maria Goretti Hospital. Divided into three groups were 98 participants (obese, overweight and normal-weight patients) according to BMI and were analyzed for three adipokines and six hormone peptides in blood serum and seminal plasma using Luminex assay. Standard semen analysis was performed for ejaculate volume, sperm concentration, total sperm count, motility, morphology and leukocytes.
+
+ Results: In all groups of subjects, we observed a higher concentration of blood serum c-peptide, GIP, PAI-1, leptin, ghrelin and GLP-1 in comparison to seminal plasma; differently, higher levels in seminal plasma were observed for insulin and visfatin. In comparison to the non-obese subjects, obese subjects showed a higher blood serum concentration of c-peptide, GLP-1, GIP and leptin and a higher concentration of seminal plasma of GIP and insulin. Total sperm count, progressive motility, motility, and atypical forms directly correlated with PAI-1 and visfatin, whereas GLP-1 directly correlated only with total progressive motility.
+
+ Conclusion: Obese men showed a different pattern of blood serum and seminal plasma adipokines and hormone peptides concentrations in comparison to normal-weight men. Furthermore, these molecules correlated with functional seminal parameters. Our findings support the option to consider these molecules as new biomarkers and pharmacological targets for a new therapeutic approach in male infertility. However, further studies identifying other potential biomarkers of male infertility with important clinical implication and characterizing their mechanisms of action are mandatory. Copyright © 2021 Antinozzi, Lista, Caponecchia, Salacone, Minganti, Battaglia, Di Luigi and Sgro.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hormones). 0 (Peptides). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.681939
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Antinozzi&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Exploratory+Analysis+in+the+Differences+in+Blood+Serum+and+Seminal+Plasma+of+Adipose-Tissue+Related+Peptides+in+Obese+and+Non-Obese+Men+and+Their+Correlations+With+Semen+Parameters.&volume=12&issue=&spage=681939&epage=&date=2021&doi=10.3389%2Ffendo.2021.681939&pmid=34393997&sid=OVID:medline
+
+<782>
+Unique Identifier
+ 34391409
+Title
+ Areca catechu-(Betel-nut)-induced whole transcriptome changes in a human monocyte cell line that may have relevance to diabetes and obesity; a pilot study.
+Source
+ BMC Endocrine Disorders. 21(1):165, 2021 Aug 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cardosa SR; Ogunkolade BW; Lowe R; Savage E; Mein CA; Boucher BJ; Hitman GA
+Authors Full Name
+ Cardosa, Shirleny R; Ogunkolade, B William; Lowe, Rob; Savage, Emanuel; Mein, Charles A; Boucher, Barbara J; Hitman, Graham A.
+Institution
+ Cardosa, Shirleny R. Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
+ Ogunkolade, B William. Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
+ Lowe, Rob. Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
+ Savage, Emanuel. Barts and The London Genome Centre, Blizard Institute, Queen Mary University of London, London, UK.
+ Mein, Charles A. Barts and The London Genome Centre, Blizard Institute, Queen Mary University of London, London, UK.
+ Boucher, Barbara J. Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
+ Hitman, Graham A. Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. g.a.hitman@qmul.ac.uk.
+MeSH Subject Headings
+ *Areca/ch [Chemistry]
+ *Arecoline/pd [Pharmacology]
+ Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ *Diabetes Mellitus, Type 2/ge [Genetics]
+ Follow-Up Studies
+ *Gene Expression Regulation/de [Drug Effects]
+ Humans
+ *Metabolic Syndrome/ge [Genetics]
+ Monocytes/de [Drug Effects]
+ *Monocytes/me [Metabolism]
+ Monocytes/pa [Pathology]
+ *Obesity/ge [Genetics]
+ Pilot Projects
+ Prognosis
+ *Transcriptome/de [Drug Effects]
+Keyword Heading
+ Betel-nut
+ Obesity
+ RNA-sequencing
+ Transcriptomics
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Betel-nut consumption is the fourth most common addictive habit globally and there is good evidence linking the habit to obesity, type 2 diabetes (T2D) and the metabolic syndrome. The aim of our pilot study was to identify gene expression relevant to obesity, T2D and the metabolic syndrome using a genome-wide transcriptomic approach in a human monocyte cell line incubated with arecoline and its nitrosated products.
+
+ RESULTS: The THP1 monocyte cell line was incubated separately with arecoline and 3-methylnitrosaminopropionaldehyde (MNPA) in triplicate for 24 h and pooled cDNA indexed paired-end libraries were sequenced (Illumina NextSeq 500). After incubation with arecoline and MNPA, 15 and 39 genes respectively had significant changes in their expression (q < 0.05, log fold change 1.5). Eighteen of those genes have reported associations with T2D and obesity in humans; of these genes there was most marked evidence for CLEC10A, MAPK8IP1, NEGR1, NQ01 and INHBE genes.
+
+ CONCLUSIONS: Our preliminary studies have identified a large number of genes relevant to obesity, T2D and metabolic syndrome whose expression was changed significantly in human TPH1 cells following incubation with betel-nut derived arecoline or with MNPA. These findings require validation by further cell-based work and investigation amongst betel-chewing communities. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 4ALN5933BH (Arecoline).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12902-021-00827-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cardosa&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Areca+catechu-%28Betel-nut%29-induced+whole+transcriptome+changes+in+a+human+monocyte+cell+line+that+may+have+relevance+to+diabetes+and+obesity%3B+a+pilot+study.&volume=21&issue=1&spage=165&epage=&date=2021&doi=10.1186%2Fs12902-021-00827-1&pmid=34391409&sid=OVID:medline
+
+<783>
+Unique Identifier
+ 34386816
+Title
+ Increasing Vegetable Intake Decreases Urinary Acidity and Bone Resorption Marker in Overweight and Obese Adults: An 8-Week Randomized Controlled Trial.
+Source
+ Journal of Nutrition. 151(11):3413-3420, 2021 11 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cao JJ; Roemmich JN; Sheng X; Jahns L
+Author NameID
+ Cao, Jay J; ORCID: https://orcid.org/0000-0002-5453-0176
+ Roemmich, James N; ORCID: https://orcid.org/0000-0002-6270-9678
+ Jahns, Lisa; ORCID: https://orcid.org/0000-0002-1828-6962
+Authors Full Name
+ Cao, Jay J; Roemmich, James N; Sheng, Xiaoming; Jahns, Lisa.
+Institution
+ Cao, Jay J. USDA, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA.
+ Roemmich, James N. USDA, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA.
+ Sheng, Xiaoming. Applied Statistics, University of Utah College of Nursing, Salt Lake City, UT, USA.
+ Jahns, Lisa. USDA, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers
+ Bone Resorption/pc [Prevention & Control]
+ *Bone Resorption
+ Diet
+ Humans
+ Middle Aged
+ Obesity
+ Overweight
+ *Vegetables
+ Young Adult
+Keyword Heading
+ acid-base balance
+ bone
+ carotenoids
+ resorption and formation markers
+ vegetable
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Controlled intervention trials are needed to confirm a positive association from epidemiological studies between vegetable consumption and bone health.
+
+ OBJECTIVE: We investigated whether providing vegetables at the Dietary Guidelines for Americans (DGA) recommended amount affects excretion of acid and calcium in urine and bone turnover markers in serum in adults with low vegetable intake.
+
+ METHODS: In total, 102 adults (19 males and 83 females, age 18-65 y, BMI >=25 kg/m2) consuming <=1 serving of vegetables (128 g raw leafy or 64 g cooked vegetables) per d were recruited in a 2-arm, parallel, randomized, controlled, and community-based 8-wk feeding intervention trial. The 2 arms included a vegetable intervention (VI) during which participants received extra vegetables (~270 g/d) and an attention control (CON) group that conducted only the testing visits. Measurements included nutrient intake, plasma carotenoids, and bone-related markers in serum and urine. Differences between CON and VI at week 8 were tested using the ANCOVA with baseline values as a covariate.
+
+ RESULTS: Compared with CON, carotenoid intake (mean +/- SD) was higher (6.4 +/- 3.4 compared with 2.0 +/- 1.2 mg/d) (P < 0.01) and dietary potential renal acid load was lower (20 +/- 13 compared with 3.4 +/- 14 mEq/d) (P < 0.01) in VI. Compared with CON at week 8, urine titratable acid and Mg were 24 and 26% lower, respectively, while urine pH was 3% greater (P < 0.05) and serum C-terminal telopeptide of type I collagen (CTX) was 19% lower in VI. There were no group differences in serum concentrations of propeptide of type 1 procollagen and tartrate-resistant acid phosphatase or urinary excretion of deoxypyridinoline and CTX.
+
+ CONCLUSIONS: Consumption of vegetables at the DGA-recommended amount by adults with low vegetable intake potentially benefits bone health. This trial was registered at clinicaltrials.gov as NCT02585102. Copyright Published by Oxford University Press on behalf of the American Society for Nutrition 2021.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1093%2fjn%2fnxab255
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cao&issn=0022-3166&title=Journal+of+Nutrition&atitle=Increasing+Vegetable+Intake+Decreases+Urinary+Acidity+and+Bone+Resorption+Marker+in+Overweight+and+Obese+Adults%3A+An+8-Week+Randomized+Controlled+Trial.&volume=151&issue=11&spage=3413&epage=3420&date=2021&doi=10.1093%2Fjn%2Fnxab255&pmid=34386816&sid=OVID:medline
+
+<784>
+Unique Identifier
+ 34382943
+Title
+ Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10.
+Source
+ Journal of Molecular Endocrinology. 67(4):173-188, 2021 09 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alhallak I; Wolter KG; Castro Munoz A; Simmen FA; Ward RJ; Petty SA; Li LX; Simmen RCM
+Authors Full Name
+ Alhallak, Iad; Wolter, Keith G; Castro Munoz, Ana; Simmen, Frank A; Ward, Richard J; Petty, Stacy A; Li, Lin-Xi; Simmen, Rosalia C M.
+Institution
+ Alhallak, Iad. Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+ Wolter, Keith G. Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+ Castro Munoz, Ana. Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+ Simmen, Frank A. Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+ Simmen, Frank A. The Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+ Ward, Richard J. Harding University, Searcy, Arkansas, USA.
+ Petty, Stacy A. Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+ Li, Lin-Xi. Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+ Simmen, Rosalia C M. Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+ Simmen, Rosalia C M. The Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
+MeSH Subject Headings
+ Adipocytes/im [Immunology]
+ Adipocytes/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Adiposity
+ Adult
+ Biomarkers
+ *Breast/me [Metabolism]
+ Breast/pa [Pathology]
+ Breast Neoplasms/et [Etiology]
+ Breast Neoplasms/me [Metabolism]
+ Breast Neoplasms/pa [Pathology]
+ Breast Neoplasms/su [Surgery]
+ Cytokines/ge [Genetics]
+ Cytokines/me [Metabolism]
+ *Epithelium/me [Metabolism]
+ Female
+ Gene Expression
+ Gonadal Steroid Hormones/bl [Blood]
+ Gonadal Steroid Hormones/me [Metabolism]
+ Humans
+ Immunohistochemistry
+ Inflammation Mediators/me [Metabolism]
+ *Interleukin-10/me [Metabolism]
+ Middle Aged
+ Models, Biological
+ Obesity/me [Metabolism]
+ *Phenotype
+ *Premenopause/me [Metabolism]
+ T-Lymphocyte Subsets/im [Immunology]
+ T-Lymphocyte Subsets/me [Metabolism]
+ T-Lymphocyte Subsets/pa [Pathology]
+ Telomere/ge [Genetics]
+ Telomere/me [Metabolism]
+ Young Adult
+Keyword Heading
+ breast adiposity
+ breast cancer
+ immune cells
+ interleukin 10
+ obesity
+ premenopausal
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Epidemiological studies inversely associate BMI with breast cancer risk in premenopausal women, but the pathophysiological linkage remains ill-defined. Despite the documented relevance of the 'local' environment to breast cancer progression and the well-accepted differences in transcriptome and metabolic properties of anatomically distinct fat depots, specific breast adipose contributions to the proliferative potential of non-diseased breast glandular compartment are not fully understood. To address early breast cancer causation in the context of obesity status, we compared the cellular and molecular phenotypes of breast adipose and matched breast glandular tissue from premenopausal non-obese (mean BMI = 27 kg/m2) and obese (mean BMI = 44 kg/m2) women. Breast adipose from obese women showed higher expression levels of adipogenic, pro-inflammatory, and estrogen synthetic genes than from non-obese women. Obese breast glandular tissue displayed lower proliferation and inflammatory status and higher expression of anti-proliferative/pro-senescence biomarkers TP53 and p21 than from non-obese women. Transcript levels for T-cell receptor and co-receptors CD3 and CD4 were higher in breast adipose of obese cohorts, coincident with elevated adipose interleukin 10 (IL10) and FOXP3 gene expression. In human breast epithelial cell lines MCF10A and HMEC, recombinant human IL10 reduced cell viability and CCND1 transcript levels, increased those of TP53 and p21, and promoted (MCF10A) apoptosis. Our findings suggest that breast adipose-associated IL10 may mediate paracrine interactions between non-diseased breast adipose and breast glandular compartments and highlight how breast adipose may program the local inflammatory milieu, partly by recruiting FOXP3+ T regulatory cells, to influence premenopausal breast cancer risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Gonadal Steroid Hormones). 0 (Inflammation Mediators). 130068-27-8 (Interleukin-10).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1530%2fJME-21-0100
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alhallak&issn=0952-5041&title=Journal+of+Molecular+Endocrinology&atitle=Breast+adipose+regulation+of+premenopausal+breast+epithelial+phenotype+involves+interleukin+10.&volume=67&issue=4&spage=173&epage=188&date=2021&doi=10.1530%2FJME-21-0100&pmid=34382943&sid=OVID:medline
+
+<785>
+Unique Identifier
+ 34381461
+Title
+ Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue.
+Source
+ Frontiers in Immunology. 12:719979, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Felix I; Jokela H; Karhula J; Kotaja N; Savontaus E; Salmi M; Rantakari P
+Authors Full Name
+ Felix, Ines; Jokela, Heli; Karhula, Joonas; Kotaja, Noora; Savontaus, Eriika; Salmi, Marko; Rantakari, Pia.
+Institution
+ Felix, Ines. Turku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland.
+ Felix, Ines. Research Centre for Infection and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland.
+ Felix, Ines. InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
+ Jokela, Heli. Turku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland.
+ Jokela, Heli. Research Centre for Infection and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland.
+ Jokela, Heli. InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
+ Karhula, Joonas. Turku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland.
+ Karhula, Joonas. Research Centre for Infection and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland.
+ Karhula, Joonas. InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
+ Kotaja, Noora. Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
+ Savontaus, Eriika. Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
+ Savontaus, Eriika. Clinical Pharmacology, Turku University Hospital, Turku, Finland.
+ Salmi, Marko. InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
+ Salmi, Marko. MediCity Research Laboratory, University of Turku, Turku, Finland.
+ Rantakari, Pia. Turku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland.
+ Rantakari, Pia. Research Centre for Infection and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland.
+ Rantakari, Pia. InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
+MeSH Subject Headings
+ Adipose Tissue/im [Immunology]
+ Adipose Tissue/me [Metabolism]
+ Adipose Tissue, White/im [Immunology]
+ *Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers
+ Cell Differentiation
+ Cell Plasticity/ge [Genetics]
+ Cell Plasticity/im [Immunology]
+ Cellular Reprogramming
+ Computational Biology
+ Energy Metabolism
+ Immunohistochemistry
+ Immunophenotyping
+ Macrophages/im [Immunology]
+ *Macrophages/me [Metabolism]
+ Male
+ Mice
+ Mice, Knockout
+ Models, Animal
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Phagocytosis
+ *Proteome/me [Metabolism]
+ Proteomics/mt [Methods]
+ *Proteomics
+ Single-Cell Analysis/mt [Methods]
+ *Single-Cell Analysis
+Keyword Heading
+ adipose tissue
+ developmental origin
+ macrophage
+ mass cytometry (CyTOF)
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipose tissue macrophages (ATMs) regulate homeostasis and contribute to the metabolically harmful chronic inflammation in obese individuals. While evident heterogeneity of resident ATMs has been described previously, their phenotype, developmental origin, and functionality remain inconsistent. We analyzed white adipose tissue (WAT) during homeostasis and diet interventions using comprehensive and unbiased single-cell mass cytometry and genetic lineage tracking models. We now provide a uniform definition of individual subsets of resident ATMs. We show that in lean mice, WAT co-harbors eight kinetically evolving CD206+ macrophage subpopulations (defined by TIM4, CD163, and MHC II) and two CD206- macrophage subpopulations. TIM4-CD163+, TIM4-CD163- and CD206- macrophage populations are largely bone marrow-derived, while the proliferating TIM4+CD163+ subpopulation is of embryonic origin. All macrophage subtypes are active in phagocytosis, endocytosis, and antigen processing in vitro, whereas TIM4+CD163+ cells are superior in scavenging in vivo. A high-fat diet induces massive infiltration of CD206- macrophages and selective down-regulation of MHC II on TIM4+ macrophages. These changes are reversed by dietary intervention. Thus, the developmental origin and environment jointly regulate the functional malleability of resident ATMs. Copyright © 2021 Felix, Jokela, Karhula, Kotaja, Savontaus, Salmi and Rantakari.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteome).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffimmu.2021.719979
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Felix&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Single-Cell+Proteomics+Reveals+the+Defined+Heterogeneity+of+Resident+Macrophages+in+White+Adipose+Tissue.&volume=12&issue=&spage=719979&epage=&date=2021&doi=10.3389%2Ffimmu.2021.719979&pmid=34381461&sid=OVID:medline
+
+<786>
+Unique Identifier
+ 34369413
+Title
+ Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm?.
+Source
+ Blood Coagulation & Fibrinolysis. 32(8):544-549, 2021 Dec 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gurbel PA; Bliden KP; Levy JH; Walia N; Rapista N; Cho A; Jerjian C; Tantry US
+Authors Full Name
+ Gurbel, Paul A; Bliden, Kevin P; Levy, Jerrold H; Walia, Naval; Rapista, Nicole; Cho, Alastair; Jerjian, Christophe; Tantry, Udaya S.
+Institution
+ Gurbel, Paul A. Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland.
+ Bliden, Kevin P. Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland.
+ Levy, Jerrold H. Departments of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
+ Walia, Naval. Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland.
+ Rapista, Nicole. Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland.
+ Cho, Alastair. Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland.
+ Jerjian, Christophe. Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland.
+ Tantry, Udaya S. Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Lifebridge Health, Baltimore, Maryland.
+MeSH Subject Headings
+ Adult
+ Black or African American/sn [Statistics & Numerical Data]
+ Aged
+ Aged, 80 and over
+ Biomarkers
+ *COVID-19/bl [Blood]
+ COVID-19/co [Complications]
+ COVID-19/ep [Epidemiology]
+ COVID-19 Testing
+ Cardiovascular Diseases/ep [Epidemiology]
+ Comorbidity
+ Diabetes Mellitus/ep [Epidemiology]
+ Early Diagnosis
+ Female
+ Fibrin/an [Analysis]
+ Fibrin Clot Lysis Time
+ Fibrinogen/an [Analysis]
+ Hospitalization
+ Humans
+ Hyperlipidemias/ep [Epidemiology]
+ L-Lactate Dehydrogenase/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Organ Dysfunction Scores
+ Prognosis
+ Prospective Studies
+ *SARS-CoV-2
+ Thrombelastography
+ Thrombophilia/bl [Blood]
+ *Thrombophilia/di [Diagnosis]
+ Thrombophilia/dt [Drug Therapy]
+ Thrombophilia/et [Etiology]
+ Treatment Outcome
+ White People/sn [Statistics & Numerical Data]
+Abstract
+ Standard biomarkers have been widely used for COVID-19 diagnosis and prognosis. We hypothesize that thrombogenicity metrics measured by thromboelastography will provide better diagnostic and prognostic utility versus standard biomarkers in COVID-19 positive patients. In this observational prospective study, we included 119 hospitalized COVID-19 positive patients and 15 COVID-19 negative patients. On admission, we measured standard biomarkers and thrombogenicity using a novel thromboelastography assay (TEG-6s). In-hospital all-cause death and thrombotic occurrences (thromboembolism, myocardial infarction and stroke) were recorded. Most COVID-19 patients were African--Americans (68%). COVID-19 patients versus COVID-19 negative patients had higher platelet-fibrin clot strength (P-FCS), fibrin clot strength (FCS) and functional fibrinogen level (FLEV) (P <= 0.003 for all). The presence of high TEG-6 s metrics better discriminated COVID-19 positive from negative patients. COVID-19 positive patients with sequential organ failure assessment (SOFA) score at least 3 had higher P-FCS, FCS and FLEV than patients with scores less than 3 (P <= 0.001 for all comparisons). By multivariate analysis, the in-hospital composite endpoint occurrence of death and thrombotic events was independently associated with SOFA score more than 3 [odds ratio (OR) = 2.9, P = 0.03], diabetes (OR = 3.3, P = 0.02) and FCS > 40 mm (OR = 3.4, P = 0.02). This largest observational study suggested the early diagnostic and prognostic utility of thromboelastography to identify COVID-19 and should be considered hypothesis generating. Our results also support the recent FDA guidance regarding the importance of measurement of whole blood viscoelastic properties in COVID-19 patients. Our findings are consistent with the observation of higher hospitalization rates and poorer outcomes for African--Americans with COVID-19. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9001-31-4 (Fibrin). 9001-32-5 (Fibrinogen). EC 1-1-1-27 (L-Lactate Dehydrogenase).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1097%2fMBC.0000000000001069
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gurbel&issn=0957-5235&title=Blood+Coagulation+%26+Fibrinolysis&atitle=Thrombogenicity+markers+for+early+diagnosis+and+prognosis+in+COVID-19%3A+a+change+from+the+current+paradigm%3F.&volume=32&issue=8&spage=544&epage=549&date=2021&doi=10.1097%2FMBC.0000000000001069&pmid=34369413&sid=OVID:medline
+
+<787>
+Unique Identifier
+ 34364265
+Title
+ Effect of the consumption of yacon flour and energy-restricted diet on glycation markers, and association between these markers and factors linked to obesity in adults with excess body weight: A randomized, double-blind, placebo-controlled clinical trial.
+Source
+ Nutrition. 91-92:111395, 2021 Nov-Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ribeiro PVM; Machado AM; da Silva NBM; de Oliveira LL; Alfenas RCG
+Authors Full Name
+ Ribeiro, Priscila Vaz de Melo; Machado, Adriane Moreira; da Silva, Nayara Benedito Martins; de Oliveira, Leandro Licursi; Alfenas, Rita de Cassia Goncalves.
+Institution
+ Ribeiro, Priscila Vaz de Melo. Departamento de Nutricao e Saude, Universidade Federal de Vicosa, Vicosa, Brazil. Electronic address: priscilavazdemelo@yahoo.com.br.
+ Machado, Adriane Moreira. Departamento de Nutricao e Saude, Universidade Federal de Vicosa, Vicosa, Brazil.
+ da Silva, Nayara Benedito Martins. Departamento de Ciencia e Tecnologia de Alimentos, Universidade Federal de Vicosa, Vicosa, Brazil.
+ de Oliveira, Leandro Licursi. Departamento de Biologia Geral, Universidade Federal de Vicosa, Vicosa, Brazil.
+ Alfenas, Rita de Cassia Goncalves. Departamento de Nutricao e Saude, Universidade Federal de Vicosa, Vicosa, Brazil.
+MeSH Subject Headings
+ Adult
+ Asteraceae
+ Biomarkers/bl [Blood]
+ *Caloric Restriction
+ Diet
+ *Flour
+ *Glycation End Products, Advanced
+ Humans
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Weight Gain
+Keyword Heading
+ Advanced glycation end products
+ Amadori products
+ Fructooligosaccharides
+ Overweight
+ sRAGE
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Regardless of the positive effect of yacon on metabolic markers, this food contains fructose molecules, which can originate advanced glycation end products (AGEs). High AGEs serum concentrations can contribute to excess body weight. We evaluated the effect of consuming an energy-restricted diet and yacon flour on glycation markers concentrations, and the associations between these markers and factors linked to obesity in adults with excess body weight.
+
+ METHODS: Twenty-six adults with excess body weight were included in this randomized, parallel, double-blind, placebo-controlled, 6-week clinical trial. Subjects were randomly allocated to the control group (n = 13) or the yacon-flour group (n = 13), and daily consumed a breakfast drink either not containing or containing 25 g of yacon flour (8.7 g of fructooligosaccharides). Energy-restricted diets were prescribed for both groups. Biochemical markers, anthropometric variables, and body composition were evaluated at baseline and the end of the study.
+
+ RESULTS: AGEs and early glycation products did not increase in the yacon flour group. Soluble receptor for AGEs (sRAGE) decreased regardless of group. Besides, changes in AGEs were positively associated with changes in body fat (beta = 0.04, P = 0.038) and in sRAGE, with insulin (beta = 0.02, P = 0.035) and homeostasis model assessment index of insulin resistance (beta = 0.01, P = 0.049).
+
+ CONCLUSIONS: The consumption of 25 g of yacon flour associated with an energy-restricted diet did not increase concentrations of glycation markers. Changes in glycation markers were positively associated with changes in consolidated anthropometric and biochemical markers related to being overweight. Assessing glycation markers may be a useful strategy for monitoring responses to dietary interventions in subjects with excess body weight. Copyright © 2021 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycation End Products, Advanced).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.nut.2021.111395
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ribeiro&issn=0899-9007&title=Nutrition&atitle=Effect+of+the+consumption+of+yacon+flour+and+energy-restricted+diet+on+glycation+markers%2C+and+association+between+these+markers+and+factors+linked+to+obesity+in+adults+with+excess+body+weight%3A+A+randomized%2C+double-blind%2C+placebo-controlled+clinical+trial.&volume=91-92&issue=&spage=111395&epage=&date=2021&doi=10.1016%2Fj.nut.2021.111395&pmid=34364265&sid=OVID:medline
+
+<788>
+Unique Identifier
+ 34356001
+Title
+ Association between metabolic status and gut microbiome in obese populations.
+Source
+ Microbial Genomics. 7(8), 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zeng Q; Yang Z; Wang F; Li D; Liu Y; Wang D; Zhao X; Li Y; Wang Y; Feng X; Chen J; Li Y; Zheng Y; Kenney T; Gu H; Feng S; Li S; He Y; Xu X; Dai W
+Authors Full Name
+ Zeng, Qiang; Yang, Zhenyu; Wang, Fei; Li, Dongfang; Liu, Yanhong; Wang, Daxi; Zhao, Xiaolan; Li, Yinhu; Wang, Yu; Feng, Xin; Chen, Jiaxing; Li, Yongli; Zheng, Yuejie; Kenney, Toby; Gu, Hong; Feng, Su; Li, Shuangcheng; He, Yuan; Xu, Ximing; Dai, Wenkui.
+Institution
+ Zeng, Qiang. Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, PR China.
+ Yang, Zhenyu. School of Statistics and Data Science, Nankai University, Tianjin 300000, PR China.
+ Yang, Zhenyu. Key Laboratory for Medical Data Analysis and Statistical Research of Tianjin, Tianjin 300000, PR China.
+ Wang, Fei. Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, PR China.
+ Li, Dongfang. Department of Microbial Research, WeHealthGene Institute, Shenzhen 518000, PR China.
+ Liu, Yanhong. Department of Microbial Research, WeHealthGene Institute, Shenzhen 518000, PR China.
+ Wang, Daxi. Melbourne Veterinary School, Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Victoria 3010, Australia.
+ Zhao, Xiaolan. Southwest Hospital, Third Military Medical University, Chongqing 400000, PR China.
+ Li, Yinhu. Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong 999077, PR China.
+ Wang, Yu. Health Management Center, 91st Hospital of the People's Liberation Army, Quanzhou 362000, PR China.
+ Feng, Xin. Department of Microbial Research, WeHealthGene Institute, Shenzhen 518000, PR China.
+ Chen, Jiaxing. Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong 999077, PR China.
+ Li, Yongli. Department of Health Management, Henan Provincial People's Hospital, Zhengzhou 450003, PR China.
+ Zheng, Yuejie. Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen 518000, PR China.
+ Kenney, Toby. Department of Mathematics and Statistics, Dalhousie University, Halifax 15000, Canada.
+ Gu, Hong. Department of Mathematics and Statistics, Dalhousie University, Halifax 15000, Canada.
+ Feng, Su. School of Statistics and Data Science, Nankai University, Tianjin 300000, PR China.
+ Li, Shuangcheng. Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong 999077, PR China.
+ He, Yuan. Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, PR China.
+ He, Yuan. National Research Institute for Health, Beijing 100000, PR China.
+ Xu, Ximing. School of Statistics and Data Science, Nankai University, Tianjin 300000, PR China.
+ Xu, Ximing. Key Laboratory for Medical Data Analysis and Statistical Research of Tianjin, Tianjin 300000, PR China.
+ Dai, Wenkui. Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518000, PR China.
+MeSH Subject Headings
+ *Bacteria/cl [Classification]
+ Bacteria/ge [Genetics]
+ Biomarkers
+ China
+ Cohort Studies
+ Diet
+ Feces/mi [Microbiology]
+ Gastrointestinal Microbiome/ge [Genetics]
+ *Gastrointestinal Microbiome
+ Humans
+ Metabolic Diseases
+ Metagenome
+ *Obesity
+Keyword Heading
+ clinical indicators
+ gut microbiome
+ metabolic abnormality
+ obesity
+ two cohorts
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Despite that obesity is associated with many metabolic diseases, a significant proportion (10-30 %) of obese individuals is recognized as 'metabolically healthy obeses' (MHOs). The aim of the current study is to characterize the gut microbiome for MHOs as compared to 'metabolically unhealthy obeses' (MUOs). We compared the gut microbiome of 172 MHO and 138 MUO individuals from Chongqing (China) (inclined to eat red meat and food with a spicy taste), and performed validation with selected biomarkers in 40 MHOs and 33 MUOs from Quanzhou (China) (inclined to eat seafood and food with a light/bland taste). The genera Alistipes, Faecalibacterium and Odoribacter had increased abundance in both Chongqing and Quanzhou MHOs. We also observed different microbial functions in MUOs compared to MHOs, including an increased abundance of genes associated with glycan biosynthesis and metabolism. In addition, the microbial gene markers identified from the Chongqing cohort bear a moderate accuracy [AUC (area under the operating characteristic curve)=0.69] for classifying MHOs distinct from MUOs in the Quanzhou cohort. These findings indicate that gut microbiome is significantly distinct between MHOs and MUOs, implicating the potential of the gut microbiome in stratification and refined management of obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1099%2fmgen.0.000639
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zeng&issn=2057-5858&title=Microbial+Genomics&atitle=Association+between+metabolic+status+and+gut+microbiome+in+obese+populations.&volume=7&issue=8&spage=&epage=&date=2021&doi=10.1099%2Fmgen.0.000639&pmid=34356001&sid=OVID:medline
+
+<789>
+Unique Identifier
+ 34353704
+Title
+ The effects of the Dietary Approaches to Stop Hypertension (DASH) diet on metabolic risk factors in patients with chronic disease: A systematic review and meta-analysis of randomized controlled trials.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(10):2766-2778, 2021 09 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lari A; Sohouli MH; Fatahi S; Cerqueira HS; Santos HO; Pourrajab B; Rezaei M; Saneie S; Rahideh ST
+Authors Full Name
+ Lari, Abolfazl; Sohouli, Mohammad H; Fatahi, Somaye; Cerqueira, Henrique S; Santos, Heitor O; Pourrajab, Behnaz; Rezaei, Mahshid; Saneie, Solaleh; Rahideh, Seyedeh T.
+Institution
+ Lari, Abolfazl. Student Research Committee, Faculty of public health branch, Iran University of Medical Sciences, Tehran, Iran; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Sohouli, Mohammad H. Student Research Committee, Faculty of public health branch, Iran University of Medical Sciences, Tehran, Iran; Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Fatahi, Somaye. Student Research Committee, Faculty of public health branch, Iran University of Medical Sciences, Tehran, Iran; Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical sciences, Tehran, Iran.
+ Cerqueira, Henrique S. School of Medicine, University of Sao Paulo (USP), Ribeirao Preto, Brazil.
+ Santos, Heitor O. School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil.
+ Pourrajab, Behnaz. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Rezaei, Mahshid. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
+ Saneie, Solaleh. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
+ Rahideh, Seyedeh T. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address: tayebeh_rahideh@yahoo.com.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Blood Pressure
+ Cardiometabolic Risk Factors
+ Cholesterol/bl [Blood]
+ *Dietary Approaches To Stop Hypertension
+ Female
+ Humans
+ Hypercholesterolemia/bl [Blood]
+ Hypercholesterolemia/di [Diagnosis]
+ *Hypercholesterolemia/dh [Diet Therapy]
+ Hypercholesterolemia/ep [Epidemiology]
+ Hypertension/di [Diagnosis]
+ *Hypertension/dh [Diet Therapy]
+ Hypertension/ep [Epidemiology]
+ Hypertension/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Randomized Controlled Trials as Topic
+ Risk Assessment
+ Treatment Outcome
+ Weight Loss
+ Young Adult
+Keyword Heading
+ Cardiovascular disease
+ DASH diet
+ Hypertension
+ Metabolic syndrome
+ Obesity
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: The DASH diet was designed for helping control of blood pressure but, fortunately, it can also be prescribed for many other chronic conditions. The current study intended to assess the potential effects of DASH diet on metabolic risk factors in patients with chronic disease.
+
+ DATA SYNTHESIS: We carried out a systematic literature search for RCTs from inception until July 2020. A total of 54 clinical trials were included in the final analysis. Compared to control groups, a significant lower effect of the DASH diet was noted for body weight (-1.59 kg; p < 0.001), BMI (-0.64 kg/m2; p < 0.001), and WC (-1.93 cm; p < 0.001) as well as for SBP (-3.94 mmHg; p < 0.001) and DBP (-2.44 mmHg; P < 0.001). The DASH diet significantly decreased TC (-5.12 mg/dl; p = 0.008) and LDL-C levels (-3.53 mg/dl; p = 0.041), but not HDL-C (0.30 mg/dl; p = 0.510), TG (-4.22 mg/dl; p = 0.067), and VLDL-C (-2.16 mg/dl; p = 0.062). No significant effect of the DASH diet was noted for blood glucose (-0.38 mg/dl; p = 0.216), insulin (-0.03 muIU/mL; p = 0.817), HOMA-IR (-0.15; p = 0.132), and CRP (-0.33 mg/l; p = 0.173).
+
+ CONCLUSIONS: The DASH diet is a feasible approach to weight loss and to control blood pressure and hypercholesterolemia. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.05.030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lari&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=The+effects+of+the+Dietary+Approaches+to+Stop+Hypertension+%28DASH%29+diet+on+metabolic+risk+factors+in+patients+with+chronic+disease%3A+A+systematic+review+and+meta-analysis+of+randomized+controlled+trials.&volume=31&issue=10&spage=2766&epage=2778&date=2021&doi=10.1016%2Fj.numecd.2021.05.030&pmid=34353704&sid=OVID:medline
+
+<790>
+Unique Identifier
+ 34348877
+Title
+ Efficacy and effects of bariatric surgery in the treatment of obesity: Network meta-analysis of randomized controlled trials.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(10):2815-2824, 2021 09 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cosentino C; Marchetti C; Monami M; Mannucci E; Cresci B
+Authors Full Name
+ Cosentino, Claudia; Marchetti, Cristiano; Monami, Matteo; Mannucci, Edoardo; Cresci, Barbara.
+Institution
+ Cosentino, Claudia. Diabetology, Careggi Hospital, Florence, Italy. Electronic address: claudiacosentino17@hotmail.it.
+ Marchetti, Cristiano. University of Florence, Florence, Italy.
+ Monami, Matteo. Diabetology, Careggi Hospital, Florence, Italy.
+ Mannucci, Edoardo. University of Florence, Florence, Italy.
+ Cresci, Barbara. Diabetology, Careggi Hospital, Florence, Italy.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Bariatric Surgery/ae [Adverse Effects]
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Body Mass Index
+ Comorbidity
+ Female
+ Humans
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Network Meta-Analysis
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ *Obesity/su [Surgery]
+ Randomized Controlled Trials as Topic
+ Risk Assessment
+ Risk Factors
+ Treatment Outcome
+ Weight Loss
+ Young Adult
+Keyword Heading
+ Bariatric surgery
+ Network meta-analysis
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Bariatric surgery (BS) is recommended for subjects with a Body Mass Index (BMI) over of 40 kg/m2 or with a BMI between 35 and 40 kg/m2 with obesity-related comorbidities. Aim of the study was to compare different types of BS with medical therapy (MT) for the treatment of obesity.
+
+ DATA SYNTHESIS: We conducted a network-meta-analysis (NMA) including randomized clinical trials comparing different BS techniques versus MT in people with obesity, with a duration >=24 weeks (PROSPERO, #CRD42020160359). Primary endpoint was BMI. Indirect comparisons of different types of surgery were performed by NMA. Types of BS included: laparoscopic adjustable gastric banding (LAGB), Roux-en-Y gastric bypass, sleeve gastrectomy (SG), bilio-pancreatic diversion (BPD); greater curvature plication (GCP); one-anastomosis gastric bypass (OAGB); Laparoscopic Vertical Banded Gastroplasty (LVBG) and duodenal switch (DS). 43 trials were retrieved in this metanalysis. BS was associated with a significant reduction in BMI, systolic blood pressure, triglyceride and fasting glucose, and with a significant increase of HDL cholesterol when compared to MT. In direct comparisons, RYGB was more effective than LAGB, LVBG, and GCP, but less effective than DS, whereas LAGB was less effective than LVBG and SG. In the NMA, DS and BPD appeared to be more effective than other procedures.
+
+ CONCLUSIONS: BS produces a greater weight loss than MT in morbidly obese patients, inducing a greater improvement of obesity-associated metabolic parameters. Available data are insufficient to assess the effect of BS on mortality. Different surgical procedures are heterogeneous for efficacy and safety. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.06.018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cosentino&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Efficacy+and+effects+of+bariatric+surgery+in+the+treatment+of+obesity%3A+Network+meta-analysis+of+randomized+controlled+trials.&volume=31&issue=10&spage=2815&epage=2824&date=2021&doi=10.1016%2Fj.numecd.2021.06.018&pmid=34348877&sid=OVID:medline
+
+<791>
+Unique Identifier
+ 34339435
+Title
+ A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats.
+Source
+ PLoS ONE [Electronic Resource]. 16(8):e0255022, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Signore PE; Guo G; Wei Z; Zhang W; Lin A; Del Balzo U
+Author NameID
+ Del Balzo, Ughetta; ORCID: https://orcid.org/0000-0003-4102-6023
+Authors Full Name
+ Signore, Pierre E; Guo, Guangjie; Wei, Zhihua; Zhang, Weihua; Lin, Al; Del Balzo, Ughetta.
+Institution
+ Signore, Pierre E. FibroGen, Inc., San Francisco, CA, United States of America.
+ Guo, Guangjie. FibroGen, Inc., San Francisco, CA, United States of America.
+ Wei, Zhihua. FibroGen, Inc., San Francisco, CA, United States of America.
+ Zhang, Weihua. FibroGen, Inc., San Francisco, CA, United States of America.
+ Lin, Al. FibroGen, Inc., San Francisco, CA, United States of America.
+ Del Balzo, Ughetta. FibroGen, Inc., San Francisco, CA, United States of America.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Cardiomegaly/bl [Blood]
+ Cardiomegaly/co [Complications]
+ Cardiomegaly/pp [Physiopathology]
+ Cardiomyopathies/bl [Blood]
+ Cardiomyopathies/co [Complications]
+ *Cardiomyopathies/dt [Drug Therapy]
+ Cardiomyopathies/pp [Physiopathology]
+ Glucose/me [Metabolism]
+ Hemoglobins/me [Metabolism]
+ Hypertension/bl [Blood]
+ Hypertension/co [Complications]
+ Hypertension/pp [Physiopathology]
+ *Hypoxia-Inducible Factor-Proline Dioxygenases/ai [Antagonists & Inhibitors]
+ Hypoxia-Inducible Factor-Proline Dioxygenases/me [Metabolism]
+ Kidney/pp [Physiopathology]
+ Kidney Diseases/bl [Blood]
+ Kidney Diseases/co [Complications]
+ Kidney Diseases/pp [Physiopathology]
+ Male
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Prolyl-Hydroxylase Inhibitors/pd [Pharmacology]
+ *Prolyl-Hydroxylase Inhibitors/tu [Therapeutic Use]
+ Rats
+ Small Molecule Libraries/pd [Pharmacology]
+ *Small Molecule Libraries/tu [Therapeutic Use]
+Abstract
+ Prolyl hydroxylase (PH) enzymes control the degradation of hypoxia-inducible factor (HIF), a transcription factor known to regulate erythropoiesis, angiogenesis, glucose metabolism, cell proliferation, and apoptosis. HIF-PH inhibitors (HIF-PHIs) correct anemia in patients with renal disease and in animal models of anemia and kidney disease. However, the effects of HIF-PHIs on comorbidities associated with kidney disease remain largely unknown. We evaluated the effects of the HIF-PHI FG-2216 in obese ZSF1 (Ob-ZSF1) rats, an established model of kidney failure with metabolic syndrome. Following unilateral nephrectomy (Nx) at 8 weeks of age, rats were treated with 40 mg/kg FG-2216 or vehicle by oral gavage three times per week for up to 18 weeks. FG-2216 corrected blood hemoglobin levels and improved kidney function and histopathology in Nx-Ob-ZSF1 rats by increasing the glomerular filtration rate, decreasing proteinuria, and reducing peritubular fibrosis, tubular damage, glomerulosclerosis and mesangial expansion. FG-2216 increased renal glucose excretion and decreased body weight, fat pad weight, and serum cholesterol in Nx-Ob-ZSF1 rats. Additionally, FG-2216 corrected hypertension, improved diastolic and systolic heart function, and reduced cardiac hypertrophy and fibrosis. In conclusion, the HIF-PHI FG-2216 improved renal and cardiovascular outcomes, and reduced obesity in a rat model of kidney disease with metabolic syndrome. Thus, in addition to correcting anemia, HIF-PHIs may provide renal and cardiac protection to patients suffering from kidney disease with metabolic syndrome.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hemoglobins). 0 (Prolyl-Hydroxylase Inhibitors). 0 (Small Molecule Libraries). EC 1-14-11-29 (Hypoxia-Inducible Factor-Proline Dioxygenases). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1371%2fjournal.pone.0255022
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Signore&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=A+small-molecule+inhibitor+of+hypoxia-inducible+factor+prolyl+hydroxylase+improves+obesity%2C+nephropathy+and+cardiomyopathy+in+obese+ZSF1+rats.&volume=16&issue=8&spage=e0255022&epage=&date=2021&doi=10.1371%2Fjournal.pone.0255022&pmid=34339435&sid=OVID:medline
+
+<792>
+Unique Identifier
+ 34333991
+Title
+ Effects of Exercise and Weight Loss on Proximal Aortic Stiffness in Older Adults With Obesity.
+Source
+ Circulation. 144(9):684-693, 2021 08 31.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Brinkley TE; Leng I; Bailey MJ; Houston DK; Hugenschmidt CE; Nicklas BJ; Hundley WG
+Authors Full Name
+ Brinkley, Tina E; Leng, Iris; Bailey, Margie J; Houston, Denise K; Hugenschmidt, Christina E; Nicklas, Barbara J; Hundley, W Gregory.
+Institution
+ Brinkley, Tina E. Department of Internal Medicine, Section on Gerontology and Geriatric Medicine (T.E.B., D.K.H., C.E.H., B.J.N.).
+ Leng, Iris. Division of Public Health Sciences, Department of Biostatistics and Data Science (I.L.).
+ Bailey, Margie J. Hypertension and Vascular Research Center (M.J.B.), Wake Forest School of Medicine, Winston-Salem, NC.
+ Houston, Denise K. Department of Internal Medicine, Section on Gerontology and Geriatric Medicine (T.E.B., D.K.H., C.E.H., B.J.N.).
+ Hugenschmidt, Christina E. Department of Internal Medicine, Section on Gerontology and Geriatric Medicine (T.E.B., D.K.H., C.E.H., B.J.N.).
+ Nicklas, Barbara J. Department of Internal Medicine, Section on Gerontology and Geriatric Medicine (T.E.B., D.K.H., C.E.H., B.J.N.).
+ Hundley, W Gregory. Department of Internal Medicine, Virginia Commonwealth University, Richmond (W.G.H.).
+MeSH Subject Headings
+ Adiposity
+ Aged
+ Aged, 80 and over
+ Aorta, Thoracic/dg [Diagnostic Imaging]
+ *Aorta, Thoracic/pa [Pathology]
+ Biomarkers
+ Body Weight
+ Caloric Restriction
+ *Exercise
+ Female
+ Geriatric Assessment
+ *Health Impact Assessment/sn [Statistics & Numerical Data]
+ Humans
+ Magnetic Resonance Imaging
+ Male
+ *Obesity/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ Physical Fitness
+ Public Health Surveillance
+ *Vascular Stiffness
+ *Weight Loss
+Keyword Heading
+ aging
+ diet
+ exercise
+ magnetic resonance imaging
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity may accelerate age-related increases in aortic stiffness. Although aerobic exercise training generally has favorable effects on aortic structure and function, exercise alone may not be sufficient to improve aortic stiffness in older adults with obesity. We determined the effects of aerobic exercise training with and without moderate- to high-caloric restriction (CR) on the structure and function of the proximal aorta in 160 older (65-79 years) men and women with obesity (body mass index=30-45 kg/m2).
+
+ METHODS: Participants were randomly assigned to 1 of 3 groups: aerobic exercise training only (treadmill 4 days/week for 30 minutes at 65% to 70% of heart rate reserve; n=56), aerobic exercise training plus moderate CR (n=55), or aerobic exercise training plus more intensive CR (n=49) for 20 weeks. Aortic pulse wave velocity, aortic distensibility, and other measures of aortic structure and function were assessed by cardiovascular magnetic resonance imaging. Pearson correlation coefficients were examined to assess associations between changes in proximal aortic stiffness and changes in fitness, fatness, and other potential confounders.
+
+ RESULTS: Weight loss in the aerobic exercise training plus moderate CR (-8.0 kg [95% CI, -9.17 to -6.87]) and aerobic exercise training plus more intensive CR (-8.98 kg [95% CI, -10.23 to -7.73) groups was significantly greater compared with the aerobic exercise training-only group (-1.66 kg [95% CI, -2.94 to -0.38]; P<0.017 for both). There were significant treatment effects for descending aorta distensibility (P=0.008) and strain (P=0.004) and aortic arch pulse wave velocity (P=0.01) with the aerobic exercise training plus moderate CR group having a 21% increase in distensibility (P=0.016) and an 8% decrease in pulse wave velocity (P=0.058). None of the aortic stiffness measures changed significantly in the aerobic exercise training-only or aerobic exercise training plus more intensive CR groups, and there were no significant changes in any other measure of aortic structure or function in these groups. Overall, increases in aortic distensibility were correlated with improvements in body weight and body fat distribution, but these associations were not statistically significant after adjustment for multiple comparisons.
+
+ CONCLUSIONS: In older adults with obesity, combining aerobic exercise with moderate CR leads to greater improvements in proximal aortic stiffness than exercise alone. Registration: URL: https://clinicaltrials.gov; Unique identifier: NCT01048736.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1161%2fCIRCULATIONAHA.120.051943
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Brinkley&issn=0009-7322&title=Circulation&atitle=Effects+of+Exercise+and+Weight+Loss+on+Proximal+Aortic+Stiffness+in+Older+Adults+With+Obesity.&volume=144&issue=9&spage=684&epage=693&date=2021&doi=10.1161%2FCIRCULATIONAHA.120.051943&pmid=34333991&sid=OVID:medline
+
+<793>
+Unique Identifier
+ 34313765
+Title
+ Weight Loss Prior to Pregnancy and Early Gestational Glycemia: Prepare, a Randomized Clinical Trial.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 106(12):e5001-e5010, 2021 11 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ LeBlanc ES; Smith NX; Vesco KK; Hillier TA; Stevens VJ
+Author NameID
+ LeBlanc, Erin S; ORCID: https://orcid.org/0000-0002-4067-3432
+Authors Full Name
+ LeBlanc, Erin S; Smith, Ning X; Vesco, Kimberly K; Hillier, Teresa A; Stevens, Victor J.
+Institution
+ LeBlanc, Erin S. Kaiser Permanente, Center for Health Research, Portland, Oregon, USA.
+ Smith, Ning X. Kaiser Permanente, Center for Health Research, Portland, Oregon, USA.
+ Vesco, Kimberly K. Kaiser Permanente, Center for Health Research, Portland, Oregon, USA.
+ Hillier, Teresa A. Kaiser Permanente, Center for Health Research, Portland, Oregon, USA.
+ Stevens, Victor J. Kaiser Permanente, Center for Health Research, Portland, Oregon, USA.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Behavior Therapy/mt [Methods]
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Case-Control Studies
+ Diabetes, Gestational/bl [Blood]
+ Diabetes, Gestational/pa [Pathology]
+ *Diabetes, Gestational/pc [Prevention & Control]
+ Diabetes, Gestational/px [Psychology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Obesity/pp [Physiopathology]
+ Pregnancy
+ Pregnancy Trimester, First
+ Prognosis
+ *Weight Loss
+ Young Adult
+Keyword Heading
+ behavioral weight loss intervention
+ gestational diabetes
+ gestational weight management
+ obesity
+ prenatal counseling
+ prepregnancy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Women with elevated body mass index are encouraged to lose weight before pregnancy, but no trials have tested the effects of prepregnancy weight loss on risk of developing gestational diabetes.
+
+ OBJECTIVE: This work aims to determine whether prepregnancy weight loss improved the early metabolic environment as measured by early gestational diabetes diagnosis.
+
+ METHODS: This was a secondary analysis of a pragmatic randomized clinical trial conducted between May 2015 and October 2019 in an integrated health system that encouraged first-trimester gestational diabetes screening for high-risk women, including those with obesity. Women aged 18 to 40 years with a body mass index (BMI) greater than or equal to 27 who were planning pregnancy were randomly assigned to a behavioral weight loss intervention or usual care. Clinical care decisions and data collection were blind to condition assignment. We compared rates of diagnosis with gestational diabetes in early pregnancy between the groups using logistic regression.
+
+ RESULTS: Of 326 participants, 168 (89 in the intervention and 79 in usual care) had singleton pregnancies during the study period. At baseline, mean age was 31.3 +/- 3.5 years and BMI was 34.8 +/- 5.8. Fifty-nine (66%) intervention participants and 57 (72%) usual care participants underwent early screening. Among those, intervention participants were 73% less likely to be diagnosed with gestational diabetes than usual care participants (adjusted odds ratio [aOR], 0.27; 95% CI, 0.09-0.80). There was no difference in diagnosis of gestational diabetes in later pregnancy (aOR, 1.08; 95% CI, 0.41-2.81).
+
+ CONCLUSION: Participation in a prepregnancy weight loss intervention led to lower rates of gestational diabetes diagnosis in early pregnancy. This suggests positive effects of prepregnancy weight loss on the early metabolic environment, a critical factor in offspring metabolic risk. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1210%2fclinem%2fdgab547
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=LeBlanc&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Weight+Loss+Prior+to+Pregnancy+and+Early+Gestational+Glycemia%3A+Prepare%2C+a+Randomized+Clinical+Trial.&volume=106&issue=12&spage=e5001&epage=e5010&date=2021&doi=10.1210%2Fclinem%2Fdgab547&pmid=34313765&sid=OVID:medline
+
+<794>
+Unique Identifier
+ 34299336
+Title
+ Non-Coding RNAs: Novel Players in Insulin Resistance and Related Diseases. [Review]
+Source
+ International Journal of Molecular Sciences. 22(14), 2021 Jul 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Formichi C; Nigi L; Grieco GE; Maccora C; Fignani D; Brusco N; Licata G; Sebastiani G; Dotta F
+Author NameID
+ Grieco, Giuseppina Emanuela; ORCID: https://orcid.org/0000-0001-7325-6128
+ Licata, Giada; ORCID: https://orcid.org/0000-0001-6995-8581
+Authors Full Name
+ Formichi, Caterina; Nigi, Laura; Grieco, Giuseppina Emanuela; Maccora, Carla; Fignani, Daniela; Brusco, Noemi; Licata, Giada; Sebastiani, Guido; Dotta, Francesco.
+Institution
+ Formichi, Caterina. Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
+ Formichi, Caterina. Fondazione Umberto Di Mario, c/o Toscana Life Sciences, 53100 Siena, Italy.
+ Nigi, Laura. Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
+ Nigi, Laura. Fondazione Umberto Di Mario, c/o Toscana Life Sciences, 53100 Siena, Italy.
+ Grieco, Giuseppina Emanuela. Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
+ Grieco, Giuseppina Emanuela. Fondazione Umberto Di Mario, c/o Toscana Life Sciences, 53100 Siena, Italy.
+ Maccora, Carla. Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University, 00185 Rome, Italy.
+ Fignani, Daniela. Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
+ Fignani, Daniela. Fondazione Umberto Di Mario, c/o Toscana Life Sciences, 53100 Siena, Italy.
+ Brusco, Noemi. Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
+ Brusco, Noemi. Fondazione Umberto Di Mario, c/o Toscana Life Sciences, 53100 Siena, Italy.
+ Licata, Giada. Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
+ Licata, Giada. Fondazione Umberto Di Mario, c/o Toscana Life Sciences, 53100 Siena, Italy.
+ Sebastiani, Guido. Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
+ Sebastiani, Guido. Fondazione Umberto Di Mario, c/o Toscana Life Sciences, 53100 Siena, Italy.
+ Dotta, Francesco. Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
+ Dotta, Francesco. Fondazione Umberto Di Mario, c/o Toscana Life Sciences, 53100 Siena, Italy.
+ Dotta, Francesco. Tuscany Centre for Precision Medicine (CReMeP), 53100 Siena, Italy.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Humans
+ Insulin/me [Metabolism]
+ *Insulin Resistance/ge [Genetics]
+ Liver/me [Metabolism]
+ Metabolic Diseases/ge [Genetics]
+ Metabolic Diseases/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ *RNA, Untranslated/ge [Genetics]
+ RNA, Untranslated/me [Metabolism]
+Keyword Heading
+ diabetes
+ fatty liver disease
+ insulin resistance
+ non-coding RNAs
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The rising prevalence of metabolic diseases related to insulin resistance (IR) have stressed the urgent need of accurate and applicable tools for early diagnosis and treatment. In the last decade, non-coding RNAs (ncRNAs) have gained growing interest because of their potential role in IR modulation. NcRNAs are variable-length transcripts which are not translated into proteins but are involved in gene expression regulation. Thanks to their stability and easy detection in biological fluids, ncRNAs have been investigated as promising diagnostic and therapeutic markers in metabolic diseases, such as type 2 diabetes mellitus (T2D), obesity and non-alcoholic fatty liver disease (NAFLD). Here we review the emerging role of ncRNAs in the development of IR and related diseases such as obesity, T2D and NAFLD, and summarize current evidence concerning their potential clinical application.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 0 (RNA, Untranslated).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22147716
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Formichi&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Non-Coding+RNAs%3A+Novel+Players+in+Insulin+Resistance+and+Related+Diseases.&volume=22&issue=14&spage=7716&epage=&date=2021&doi=10.3390%2Fijms22147716&pmid=34299336&sid=OVID:medline
+
+<795>
+Unique Identifier
+ 34299321
+Title
+ Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests. [Review]
+Source
+ International Journal of Molecular Sciences. 22(14), 2021 Jul 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Di Ciaula A; Calamita G; Shanmugam H; Khalil M; Bonfrate L; Wang DQ; Baffy G; Portincasa P
+Author NameID
+ Di Ciaula, Agostino; ORCID: https://orcid.org/0000-0002-5476-7376
+ Calamita, Giuseppe; ORCID: https://orcid.org/0000-0003-4666-9546
+ Shanmugam, Harshitha; ORCID: https://orcid.org/0000-0002-3711-2175
+ Khalil, Mohamad; ORCID: https://orcid.org/0000-0002-5943-9531
+ Wang, David Q-H; ORCID: https://orcid.org/0000-0002-5439-7651
+ Portincasa, Piero; ORCID: https://orcid.org/0000-0001-5359-1471
+Authors Full Name
+ Di Ciaula, Agostino; Calamita, Giuseppe; Shanmugam, Harshitha; Khalil, Mohamad; Bonfrate, Leonilde; Wang, David Q-H; Baffy, Gyorgy; Portincasa, Piero.
+Institution
+ Di Ciaula, Agostino. Clinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, 70124 Bari, Italy.
+ Calamita, Giuseppe. Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", 70100 Bari, Italy.
+ Shanmugam, Harshitha. Clinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, 70124 Bari, Italy.
+ Khalil, Mohamad. Clinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, 70124 Bari, Italy.
+ Bonfrate, Leonilde. Clinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, 70124 Bari, Italy.
+ Wang, David Q-H. Marion Bessin Liver Research Center, Einstein-Mount Sinai Diabetes Research Center, Department of Medicine and Genetics, Division of Gastroenterology and Liver Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
+ Baffy, Gyorgy. Department of Medicine, VA Boston Healthcare System and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02130, USA.
+ Portincasa, Piero. Clinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, 70124 Bari, Italy.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ *Breath Tests/mt [Methods]
+ Carcinoma, Hepatocellular/me [Metabolism]
+ Hepatocytes/me [Metabolism]
+ Humans
+ Liver/pa [Pathology]
+ Liver/pp [Physiopathology]
+ Liver Cirrhosis/me [Metabolism]
+ Liver Function Tests
+ Liver Neoplasms/me [Metabolism]
+ *Mitochondria/me [Metabolism]
+ Mitochondria/pa [Pathology]
+ Mitochondria, Liver/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Non-alcoholic Fatty Liver Disease/pp [Physiopathology]
+ Obesity/me [Metabolism]
+Keyword Heading
+ breath test
+ hepatic mitochondrial function
+ hepatocellular carcinoma
+ ketoisocaproic acid
+ liver diseases
+ liver steatosis
+ methacetin
+ methionine
+ octanoic acid
+ beta-oxidation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The liver plays a key role in systemic metabolic processes, which include detoxification, synthesis, storage, and export of carbohydrates, lipids, and proteins. The raising trends of obesity and metabolic disorders worldwide is often associated with the nonalcoholic fatty liver disease (NAFLD), which has become the most frequent type of chronic liver disorder with risk of progression to cirrhosis and hepatocellular carcinoma. Liver mitochondria play a key role in degrading the pathways of carbohydrates, proteins, lipids, and xenobiotics, and to provide energy for the body cells. The morphological and functional integrity of mitochondria guarantee the proper functioning of beta-oxidation of free fatty acids and of the tricarboxylic acid cycle. Evaluation of the liver in clinical medicine needs to be accurate in NAFLD patients and includes history, physical exam, imaging, and laboratory assays. Evaluation of mitochondrial function in chronic liver disease and NAFLD is now possible by novel diagnostic tools. "Dynamic" liver function tests include the breath test (BT) based on the use of substrates marked with the non-radioactive, naturally occurring stable isotope 13C. Hepatocellular metabolization of the substrate will generate 13CO2, which is excreted in breath and measured by mass spectrometry or infrared spectroscopy. Breath levels of 13CO2 are biomarkers of specific metabolic processes occurring in the hepatocyte cytosol, microsomes, and mitochondria. 13C-BTs explore distinct chronic liver diseases including simple liver steatosis, non-alcoholic steatohepatitis, liver fibrosis, cirrhosis, hepatocellular carcinoma, drug, and alcohol effects. In NAFLD, 13C-BT use substrates such as alpha-ketoisocaproic acid, methionine, and octanoic acid to assess mitochondrial oxidation capacity which can be impaired at an early stage of disease. 13C-BTs represent an indirect, cost-effective, and easy method to evaluate dynamic liver function. Further applications are expected in clinical medicine. In this review, we discuss the involvement of liver mitochondria in the progression of NAFLD, together with the role of 13C-BT in assessing mitochondrial function and its potential use in the prevention and management of NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22147702
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Di+Ciaula&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Mitochondria+Matter%3A+Systemic+Aspects+of+Nonalcoholic+Fatty+Liver+Disease+%28NAFLD%29+and+Diagnostic+Assessment+of+Liver+Function+by+Stable+Isotope+Dynamic+Breath+Tests.&volume=22&issue=14&spage=7702&epage=&date=2021&doi=10.3390%2Fijms22147702&pmid=34299321&sid=OVID:medline
+
+<796>
+Unique Identifier
+ 34286837
+Title
+ Branched-chain Amino Acids and Relationship With Inflammation in Youth With Obesity: A Randomized Controlled Intervention Study.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 106(11):3129-3139, 2021 10 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cosentino RG; Churilla JR; Josephson S; Molle-Rios Z; Hossain MJ; Prado WL; Balagopal PB
+Author NameID
+ Balagopal, P Babu; ORCID: https://orcid.org/0000-0001-6940-0772
+Authors Full Name
+ Cosentino, Ralph G; Churilla, James R; Josephson, Samantha; Molle-Rios, Zarela; Hossain, Md Jobayer; Prado, Wagner L; Balagopal, P Babu.
+Institution
+ Cosentino, Ralph G. Department of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, FL 32224, USA.
+ Churilla, James R. Department of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, FL 32224, USA.
+ Josephson, Samantha. Biomedical Research, Nemours Children's Health System, Jacksonville, FL 32207, USA.
+ Molle-Rios, Zarela. Division of Gastroenterology, Nemours Children's Health System, Wilmington, DE 19802, USA.
+ Hossain, Md Jobayer. Biomedical Research, Nemours Children's Health System, Wilmington, DE 19802, USA.
+ Prado, Wagner L. Department of Kinesiology, California State University, San Bernardino, CA 92407, USA.
+ Balagopal, P Babu. Biomedical Research, Nemours Children's Health System, Jacksonville, FL 32207, USA.
+ Balagopal, P Babu. Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adolescent
+ *Amino Acids, Branched-Chain/me [Metabolism]
+ *Biomarkers/me [Metabolism]
+ Body Composition
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ *Cardiovascular Diseases/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Inflammation/ep [Epidemiology]
+ Inflammation/me [Metabolism]
+ *Inflammation/pa [Pathology]
+ *Insulin Resistance
+ Male
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Risk Factors
+ United States/ep [Epidemiology]
+Keyword Heading
+ biomarkers
+ branched-chain amino acids
+ cardiovascular disease
+ children
+ nutrition
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Elevated concentrations of branched-chain amino acids (BCAA) are strong predictors of type 2 diabetes mellitus (T2DM). Their association with cardiovascular disease (CVD) remains uncertain, particularly in youth.
+
+ OBJECTIVE: We investigated the role of BCAA and aromatic amino acids (AAA) in obesity, their relationships with novel biomarkers of CVD, and response to a physical activity-based lifestyle intervention (PAL-I) in a randomized controlled study in youth with normal weight (NW) and obesity (OB).
+
+ METHODS: Age (14-18 years) and Tanner stage (>=IV) matched youth (OB, n = 15 and NW, n = 6) were studied; the 15 participants with OB underwent a 3-month randomized controlled PAL-I. Circulating amino acid profile, glucose, insulin, lipids, adiponectin, retinol binding protein-4, fibrinogen, high-sensitivity C-reactive protein, interleukin-6, and 25-hydroxy vitamin-D, along with body composition, were measured at baseline and after PAL-I. Independent t tests, analysis of covariance, and mixed-effect models were used for analysis of the data.
+
+ RESULTS: Compared with NW, the concentration of various amino acids, including BCAA and AAA, were altered in OB (P < 0.05). BCAA and AAA showed baseline correlations with body composition and novel biomarkers of CVD, particularly inflammatory factors (all P < 0.05). The PAL-I produced only negligible effects (P > 0.05) on BCAA and AAA. Glutamine, glycine, and aspartic acid decreased with PAL-I (all P < 0.05).
+
+ CONCLUSION: The novel finding of the BCAA-inflammation relationship, along with strong correlations with nontraditional biomarkers of CVD, may raise the prospect of BCAA as a biomarker of CVD and evoke a potential link between obesity, T2DM, and CVD. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers).
+Publication Type
+ Journal Article. Observational Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1210%2fclinem%2fdgab538
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cosentino&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Branched-chain+Amino+Acids+and+Relationship+With+Inflammation+in+Youth+With+Obesity%3A+A+Randomized+Controlled+Intervention+Study.&volume=106&issue=11&spage=3129&epage=3139&date=2021&doi=10.1210%2Fclinem%2Fdgab538&pmid=34286837&sid=OVID:medline
+
+<797>
+Unique Identifier
+ 34267209
+Title
+ Reduced stress-associated FKBP5 DNA methylation together with gut microbiota dysbiosis is linked with the progression of obese PCOS patients.
+Source
+ Npj Biofilms & Microbiomes. 7(1):60, 2021 07 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen F; Chen Z; Chen M; Chen G; Huang Q; Yang X; Yin H; Chen L; Zhang W; Lin H; Ou M; Wang L; Chen Y; Lin C; Xu W; Yin G
+Author NameID
+ Yin, Guoshu; ORCID: https://orcid.org/0000-0002-5006-3486
+Authors Full Name
+ Chen, Fu; Chen, Zhangran; Chen, Minjie; Chen, Guishan; Huang, Qingxia; Yang, Xiaoping; Yin, Huihuang; Chen, Lan; Zhang, Weichun; Lin, Hong; Ou, Miaoqiong; Wang, Luanhong; Chen, Yongsong; Lin, Chujia; Xu, Wencan; Yin, Guoshu.
+Institution
+ Chen, Fu. Department of Clinical Nutrition, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Chen, Zhangran. Institute for Microbial Ecology, School of Medicine, Xiamen University, Xiamen, Fujian Province, China.
+ Chen, Minjie. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Chen, Minjie. Laboratory of Molecular Cardiology and Laboratory of Molecular Imaging, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Chen, Guishan. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Huang, Qingxia. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Yang, Xiaoping. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Yin, Huihuang. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Yin, Huihuang. Laboratory of Molecular Cardiology and Laboratory of Molecular Imaging, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Chen, Lan. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Zhang, Weichun. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Lin, Hong. Department of Reproductive Center, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Ou, Miaoqiong. Department of Clinical Nutrition, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Wang, Luanhong. Department of Gynecological tumor, Tumor Hospital Affiliated to Shantou University Medical College, Shantou, Guangdong Province, China.
+ Chen, Yongsong. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Lin, Chujia. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Xu, Wencan. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
+ Yin, Guoshu. Department of Endocrinology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China. yinguoshu@126.com.
+MeSH Subject Headings
+ Adult
+ Biodiversity
+ Biomarkers
+ Case-Control Studies
+ Computational Biology
+ *DNA Methylation
+ Disease Susceptibility
+ *Dysbiosis
+ Female
+ *Gastrointestinal Microbiome
+ Humans
+ Metabolome
+ Metabolomics/mt [Methods]
+ Middle Aged
+ Obesity
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ *Polycystic Ovary Syndrome/et [Etiology]
+ *Polycystic Ovary Syndrome/me [Metabolism]
+ *Stress, Physiological
+ *Tacrolimus Binding Proteins/ge [Genetics]
+ Young Adult
+Abstract
+ Polycystic ovary syndrome (PCOS) is a common endocrine disease in females that is characterized by hyperandrogenemia, chronic anovulation, and polycystic ovaries. However, the exact etiology and pathogenesis of PCOS are still unknown. The aim of this study was to clarify the bacterial, stress status, and metabolic differences in the gut microbiomes of healthy individuals and patients with high body mass index (BMI) PCOS (PCOS-HB) and normal BMI PCOS (PCOS-LB), respectively. Here, we compared the gut microbiota characteristics of PCOS-HB, PCOS-LB, and healthy controls by 16S rRNA gene sequencing, FK506-binding protein 5 (FKBP5) DNA methylation and plasma metabolite determination. Clinical parameter comparisons indicated that PCOS patients had higher concentrations of total testosterone, androstenedione, dehydroepiandrosterone sulfate, luteinizing hormone, and HOMA-IR while lower FKBP5 DNA methylation. Significant differences in bacterial diversity and community were observed between the PCOS and healthy groups but not between the PCOS-HB and PCOS-LB groups. Bacterial species number was negatively correlated with insulin concentrations (both under fasting status and 120 min after glucose load) and HOMA-IR but positively related to FKBP5 DNA methylation. Compared to the healthy group, both PCOS groups had significant changes in bacterial genera, including Prevotella_9, Dorea, Maihella, and Slackia, and plasma metabolites, including estrone sulfate, lysophosphatidyl choline 18:2, and phosphatidylcholine (22:6e/19:1). The correlation network revealed the complicated interaction of the clinical index, bacterial genus, stress indices, and metabolites. Our work links the stress responses and gut microbiota characteristics of PCOS disease, which might afford perspectives to understand the progression of PCOS. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 5-2-1 (Tacrolimus Binding Proteins). EC 5-2-1-8 (tacrolimus binding protein 5).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41522-021-00231-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=2055-5008&title=Npj+Biofilms+%26+Microbiomes&atitle=Reduced+stress-associated+FKBP5+DNA+methylation+together+with+gut+microbiota+dysbiosis+is+linked+with+the+progression+of+obese+PCOS+patients.&volume=7&issue=1&spage=60&epage=&date=2021&doi=10.1038%2Fs41522-021-00231-6&pmid=34267209&sid=OVID:medline
+
+<798>
+Unique Identifier
+ 34255136
+Title
+ Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women.
+Source
+ Amino Acids. 53(9):1391-1403, 2021 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ De Carvalho FG; Brandao CFC; Munoz VR; Batitucci G; Tavares MEA; Teixeira GR; Pauli JR; De Moura LP; Ropelle ER; Cintra DE; da Silva ASR; Junqueira-Franco MVM; Marchini JS; De Freitas EC
+Author NameID
+ De Freitas, Ellen Cristini; ORCID: http://orcid.org/0000-0002-7343-2002
+Authors Full Name
+ De Carvalho, Flavia Giolo; Brandao, Camila Fernanda Cunha; Munoz, Vitor Rosetto; Batitucci, Gabriela; Tavares, Maria Eduarda de Almeida; Teixeira, Giovana Rampazzo; Pauli, Jose Rodrigo; De Moura, Leandro Pereira; Ropelle, Eduardo Rochete; Cintra, Dennys Esper; da Silva, Adelino Sanchez Ramos; Junqueira-Franco, Marcia Varella Morandi; Marchini, Julio Sergio; De Freitas, Ellen Cristini.
+Institution
+ De Carvalho, Flavia Giolo. School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirao Preto, Sao Paulo, 14040-907, Brazil.
+ Brandao, Camila Fernanda Cunha. Internal Medicine Department, Ribeirao Preto Medical School, University of Sao Paulo-FMRP USP, Ribeirao Preto, Sao Paulo, Brazil.
+ Brandao, Camila Fernanda Cunha. State University of Minas Gerais - UEMG, Divinopolis unit, Minas Gerais, Brazil.
+ Munoz, Vitor Rosetto. Laboratory of Molecular Biology of Exercise, University of Campinas-FCA UNICAMP, Limeira, Sao Paulo, Brazil.
+ Batitucci, Gabriela. Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, Sao Paulo State University-FCFAR UNESP, Araraquara, Sao Paulo, Brazil.
+ Tavares, Maria Eduarda de Almeida. Department of Physical Education, School of Technology and Science, Sao Paulo State University-UNESP, Presidente Prudente, Sao Paulo, Brazil.
+ Teixeira, Giovana Rampazzo. Department of Physical Education, School of Technology and Science, Sao Paulo State University-UNESP, Presidente Prudente, Sao Paulo, Brazil.
+ Pauli, Jose Rodrigo. Laboratory of Molecular Biology of Exercise, University of Campinas-FCA UNICAMP, Limeira, Sao Paulo, Brazil.
+ De Moura, Leandro Pereira. Laboratory of Molecular Biology of Exercise, University of Campinas-FCA UNICAMP, Limeira, Sao Paulo, Brazil.
+ Ropelle, Eduardo Rochete. Laboratory of Molecular Biology of Exercise, University of Campinas-FCA UNICAMP, Limeira, Sao Paulo, Brazil.
+ Cintra, Dennys Esper. Laboratory of Nutritional Genomics, University of Campinas-FCA UNICAMP, Limeira, Sao Paulo, Brazil.
+ da Silva, Adelino Sanchez Ramos. School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirao Preto, Sao Paulo, 14040-907, Brazil.
+ Junqueira-Franco, Marcia Varella Morandi. Internal Medicine Department, Ribeirao Preto Medical School, University of Sao Paulo-FMRP USP, Ribeirao Preto, Sao Paulo, Brazil.
+ Marchini, Julio Sergio. Internal Medicine Department, Ribeirao Preto Medical School, University of Sao Paulo-FMRP USP, Ribeirao Preto, Sao Paulo, Brazil.
+ De Freitas, Ellen Cristini. School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirao Preto, Sao Paulo, 14040-907, Brazil. ellenfreitas@usp.br.
+ De Freitas, Ellen Cristini. Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, Sao Paulo State University-FCFAR UNESP, Araraquara, Sao Paulo, Brazil. ellenfreitas@usp.br.
+MeSH Subject Headings
+ Adipose Tissue
+ *Adipose Tissue, White/ph [Physiology]
+ Adult
+ Biomarkers/bl [Blood]
+ Body Composition
+ *Cytokines/bl [Blood]
+ *Dietary Supplements
+ *Exercise
+ Female
+ Humans
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ *Obesity/th [Therapy]
+ *Subcutaneous Fat/ph [Physiology]
+ *Taurine/ad [Administration & Dosage]
+ Young Adult
+Keyword Heading
+ Adipocyte plasticity
+ Adipose tissue
+ Inflammation
+ Obesity
+ Taurine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Interventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory process, therefore, may represent strategies for obesity treatment. We investigated the effects of taurine supplementation in conjunction with exercise on inflammatory and oxidative stress markers in plasma and scWAT of obese women. Sixteen obese women were randomized into two groups: Taurine supplementation group (Tau, n = 8) and Taurine supplementation + exercise group (Tau + Exe, n = 8). The intervention was composed of daily taurine supplementation (3 g) and exercise training for 8 weeks. Anthropometry, body fat composition, and markers of inflammatory and oxidative stress were determined in plasma and scWAT biopsy samples before and after the intervention. We found that, although taurine supplementation increased taurine plasma levels, no changes were observed for the anthropometric characteristics. However, Tau alone decreased interleukin-6 (IL-6), and in conjunction with exercise (Tau + Exe), increased anti-inflammatory interleukins (IL-15 and IL10), followed by reduced IL1beta gene expression in the scWAT of obese women. Tau and Tau + Exe groups presented reduced adipocyte size and increased connective tissue and multilocular droplets. In conclusion, taurine supplementation in conjunction with exercise modulated levels of inflammatory markers in plasma and scWAT, and improved scWAT plasticity in obese women, promoting protection against obesity-induced inflammation. TRN NCT04279600 retrospectively registered on August 18, 2019. Copyright © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 1EQV5MLY3D (Taurine).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs00726-021-03041-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=De+Carvalho&issn=0939-4451&title=Amino+Acids&atitle=Taurine+supplementation+in+conjunction+with+exercise+modulated+cytokines+and+improved+subcutaneous+white+adipose+tissue+plasticity+in+obese+women.&volume=53&issue=9&spage=1391&epage=1403&date=2021&doi=10.1007%2Fs00726-021-03041-4&pmid=34255136&sid=OVID:medline
+
+<799>
+Unique Identifier
+ 34253845
+Title
+ Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease. [Review]
+Source
+ International Journal of Obesity. 45(10):2169-2178, 2021 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kumar S; Mankowski RT; Anton SD; Babu Balagopal P
+Author NameID
+ Babu Balagopal, P; ORCID: http://orcid.org/0000-0001-6940-0772
+Authors Full Name
+ Kumar, Seema; Mankowski, Robert T; Anton, Stephen D; Babu Balagopal, P.
+Institution
+ Kumar, Seema. Division of Pediatric Endocrinology, Mayo Clinic, Rochester, MN, USA.
+ Kumar, Seema. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
+ Mankowski, Robert T. Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL, USA.
+ Anton, Stephen D. Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL, USA.
+ Babu Balagopal, P. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA. babu.balagopal@nemours.org.
+ Babu Balagopal, P. Department of Biomedical Research, Nemours Children's Health System, Jacksonville, FL, USA. babu.balagopal@nemours.org.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ Feeding Behavior/de [Drug Effects]
+ Humans
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/ge [Genetics]
+ Obesity/bl [Blood]
+ *Obesity/ge [Genetics]
+ Peptide Hormones/an [Analysis]
+ Peptide Hormones/me [Metabolism]
+ *Peptide Hormones/pd [Pharmacology]
+Abstract
+ Spexin (SPX) is a 14-amino acid neuropeptide, discovered recently using bioinformatic techniques. It is encoded by the Ch12:orf39 gene that is widely expressed in different body tissues/organs across species, and secreted into systemic circulation. Recent reports have highlighted a potentially important regulatory role of SPX in obesity and related comorbidities. SPX is also ubiquitously expressed in human tissues, including white adipose tissue. The circulating concentration of SPX is significantly lower in individuals with obesity compared to normal weight counterparts. SPX's role in obesity appears to be related to various factors, such as the regulation of energy expenditure, appetite, and eating behaviors, increasing locomotion, and inhibiting long-chain fatty acid uptake into adipocytes. Recent reports have also suggested SPX's relationship with novel biomarkers of cardiovascular disease (CVD) and glucose metabolism and evoked the potential role of SPX as a key biomarker/player in the early loss of cardiometabolic health and development of CVD and diabetes later in life. Data on age-related changes in SPX and SPX's response to various interventions are also emerging. The current review focuses on the role of SPX in obesity and related comorbidities across the life span, and its response to interventions in these conditions. It is expected that this article will provide new ideas for future research on SPX and its metabolic regulation, particularly related to cardiometabolic diseases. Copyright © 2021. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Hormones). 0 (SPX protein, human).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41366-021-00906-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kumar&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Novel+insights+on+the+role+of+spexin+as+a+biomarker+of+obesity+and+related+cardiometabolic+disease.&volume=45&issue=10&spage=2169&epage=2178&date=2021&doi=10.1038%2Fs41366-021-00906-2&pmid=34253845&sid=OVID:medline
+
+<800>
+Unique Identifier
+ 34244597
+Title
+ Body composition predictors of outcome in patients with COVID-19.
+Source
+ International Journal of Obesity. 45(10):2238-2243, 2021 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bunnell KM; Thaweethai T; Buckless C; Shinnick DJ; Torriani M; Foulkes AS; Bredella MA
+Author NameID
+ Shinnick, Daniel J; ORCID: http://orcid.org/0000-0003-4611-9245
+ Torriani, Martin; ORCID: http://orcid.org/0000-0002-6255-6413
+ Foulkes, Andrea S; ORCID: http://orcid.org/0000-0002-9520-0501
+ Bredella, Miriam A; ORCID: http://orcid.org/0000-0001-5482-0440
+Authors Full Name
+ Bunnell, Katherine M; Thaweethai, Tanayott; Buckless, Colleen; Shinnick, Daniel J; Torriani, Martin; Foulkes, Andrea S; Bredella, Miriam A.
+Institution
+ Bunnell, Katherine M. Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA, USA.
+ Thaweethai, Tanayott. Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, 50 Staniford Street, Suite 560, Boston, MA, USA.
+ Buckless, Colleen. Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA, USA.
+ Shinnick, Daniel J. Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, 50 Staniford Street, Suite 560, Boston, MA, USA.
+ Torriani, Martin. Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA, USA.
+ Foulkes, Andrea S. Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, 50 Staniford Street, Suite 560, Boston, MA, USA.
+ Bredella, Miriam A. Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA, USA. mbredella@mgh.harvard.edu.
+MeSH Subject Headings
+ Adipose Tissue/dg [Diagnostic Imaging]
+ Aged
+ Biomarkers
+ *Body Composition/ph [Physiology]
+ COVID-19/co [Complications]
+ COVID-19/dg [Diagnostic Imaging]
+ COVID-19/ep [Epidemiology]
+ *COVID-19
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/dg [Diagnostic Imaging]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Retrospective Studies
+ Tomography, X-Ray Computed
+ Treatment Outcome
+Abstract
+ BACKGROUND/OBJECTIVE: Obesity is a strong risk factor for adverse outcomes in patients hospitalized with COVID-19, however, the distribution of fat and the amount of muscle mass are more accurate risk factors than BMI. The objective of this study was to assess body composition measures obtained on opportunistic abdominal CTs as predictors of outcome in patients hospitalized with COVID-19. We hypothesized that elevated visceral and intermuscular adipose tissue would be associated with adverse outcome.
+
+ SUBJECTS/METHODS: Our retrospective study was IRB-approved and HIPAA-compliant. The study group comprised 124 patients (median age: 68 years, IQR: 56, 77; 59 weeks, 65 months) who were admitted with COVID-19 to a single hospital and who had undergone abdominal CT for clinical purposes. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), intermuscular adipose tissue (IMAT), and paraspinal and abdominal muscle cross-sectional areas (CSA) were assessed. Clinical information including prognostic factors, time of admission to the intensive care unit (ICU) and time of death within 28 days were obtained. Multivariate time-to-event competing risk models were fitted to estimate the hazard ratio (HR) for a composite outcome of ICU admission/mortality associated with a one standard deviation increase in each body compositional measure. Each model was adjusted for age, sex, race, BMI, and cardiometabolic comorbidities.
+
+ RESULTS: There were 50 patients who were admitted to the ICU or deceased over a median time of 1 day [IQR 1, 6] from hospital admission. Higher VAT/SAT ratio (HR of 1.30; 95% CI 1.04-1.62, p = 0.022) and higher IMAT CSA (HR of 1.44; 95% CI 1.10-1.89, p = 0.008) were associated with a reduced time to ICU admission or death in adjusted models.
+
+ CONCLUSION: VAT/SAT and IMAT are predictors of adverse outcome in patients hospitalized with COVID-19, independent of other established prognostic factors. This suggests that body composition measures may serve as novel biomarkers of outcome in patients with COVID-19. Copyright © 2021. The Author(s), under exclusive licence to Springer Nature Limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41366-021-00907-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bunnell&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Body+composition+predictors+of+outcome+in+patients+with+COVID-19.&volume=45&issue=10&spage=2238&epage=2243&date=2021&doi=10.1038%2Fs41366-021-00907-1&pmid=34244597&sid=OVID:medline
+
+<801>
+Unique Identifier
+ 34231954
+Title
+ Proteomics to improve phenotyping in obese patients with heart failure with preserved ejection fraction.
+Source
+ European Journal of Heart Failure. 23(10):1633-1644, 2021 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kresoja KP; Rommel KP; Wachter R; Henger S; Besler C; Kloting N; Schnelle M; Hoffmann A; Buttner P; Ceglarek U; Thiele H; Scholz M; Edelmann F; Bluher M; Lurz P
+Authors Full Name
+ Kresoja, Karl-Patrik; Rommel, Karl-Philipp; Wachter, Rolf; Henger, Sylvia; Besler, Christian; Kloting, Nora; Schnelle, Moritz; Hoffmann, Anne; Buttner, Petra; Ceglarek, Uta; Thiele, Holger; Scholz, Markus; Edelmann, Frank; Bluher, Matthias; Lurz, Philipp.
+Institution
+ Kresoja, Karl-Patrik. Department of Cardiology, Heart Center Leipzig at University Leipzig, Leipzig, Germany.
+ Rommel, Karl-Philipp. Department of Cardiology, Heart Center Leipzig at University Leipzig, Leipzig, Germany.
+ Wachter, Rolf. Clinic and Policlinic for Cardiology, University Hospital, Leipzig, Germany.
+ Henger, Sylvia. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
+ Henger, Sylvia. LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
+ Besler, Christian. Department of Cardiology, Heart Center Leipzig at University Leipzig, Leipzig, Germany.
+ Kloting, Nora. Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
+ Kloting, Nora. Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum Munchen at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
+ Schnelle, Moritz. Institute for Clinical Chemistry, University Medical Center Gottingen, Gottingen, Germany.
+ Hoffmann, Anne. Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
+ Hoffmann, Anne. Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum Munchen at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
+ Buttner, Petra. Department of Cardiology, Heart Center Leipzig at University Leipzig, Leipzig, Germany.
+ Ceglarek, Uta. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University, Leipzig, Germany.
+ Thiele, Holger. Department of Cardiology, Heart Center Leipzig at University Leipzig, Leipzig, Germany.
+ Scholz, Markus. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
+ Scholz, Markus. LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
+ Edelmann, Frank. Department of Internal Medicine and Cardiology, Charite-Universitatsmedizin Berlin, Berlin, Germany.
+ Edelmann, Frank. German Centre for Cardiovascular Research, partner site Berlin, Germany.
+ Bluher, Matthias. Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
+ Bluher, Matthias. Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum Munchen at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
+ Lurz, Philipp. Department of Cardiology, Heart Center Leipzig at University Leipzig, Leipzig, Germany.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Biomarkers
+ *Diabetes Mellitus, Type 2
+ *Heart Failure
+ Humans
+ Obesity/co [Complications]
+ Proteomics
+ Stroke Volume
+Keyword Heading
+ Biomarker
+ Fibrosis
+ Heart failure with preserved ejection fraction
+ Inflammation
+ Obesity
+ Proteomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Recent evidence points towards a distinct obese phenotype among patients with heart failure with preserved ejection fraction (HFpEF). We aimed to identify differentially expressed circulating biomarkers in obese HFpEF patients and link them to disease severity and outcomes.
+
+ METHODS AND RESULTS: From the LIFE-Heart study, 999 patients with HFpEF and 999 patients without heart failure (no-HF) were selected and 92 circulating serum biomarkers were measured using a proximity extension assay. Elevation of identified biomarkers was validated in 220 patients from the Aldo-DHF trial with diagnosed HFpEF. HFpEF patients were older and had more comorbidities including coronary artery disease and type 2 diabetes as compared to no-HF patients (P < 0.05 for all). After adjusting for covariates, adrenomedullin (ADM), galectin-9 (Gal-9), thrombospondin-2 (THBS-2), CD4, and tumour necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) were significantly higher in obese HFpEF patients [body mass index (BMI) >=30 kg/m2 , n = 464] as compared to lean HFpEF (BMI <30 kg/m2 , n = 535) and obese no-HF patients (BMI >=30 kg/m2 , n = 387) (P < 0.001 for both); these findings were verified in the Aldo-DHF validation cohort (P < 0.001). Except for CD4 these proteins were associated with increased estimates of left atrial pressure in a linear fashion. Importantly, ADM and CD4 were associated with increased mortality in obese HFpEF patients after adjusting for covariates.
+
+ CONCLUSION: Obese HFpEF patients exhibit higher circulating biomarkers of volume expansion (ADM), myocardial fibrosis (THBS-2) and systemic inflammation (Gal-9, CD4) compared to obese non-HFpEF or lean HFpEF patients. These findings support the clinical definition of a distinct obese HFpEF phenotype and might merit further investigation. Copyright © 2021 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1002%2fejhf.2291
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kresoja&issn=1388-9842&title=European+Journal+of+Heart+Failure&atitle=Proteomics+to+improve+phenotyping+in+obese+patients+with+heart+failure+with+preserved+ejection+fraction.&volume=23&issue=10&spage=1633&epage=1644&date=2021&doi=10.1002%2Fejhf.2291&pmid=34231954&sid=OVID:medline
+
+<802>
+Unique Identifier
+ 34230580
+Title
+ Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals.
+Source
+ Scientific Reports. 11(1):13883, 2021 07 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Rashed F; Sindhu S; Al Madhoun A; Ahmad Z; AlMekhled D; Azim R; Al-Kandari S; Wahid MA; Al-Mulla F; Ahmad R
+Authors Full Name
+ Al-Rashed, Fatema; Sindhu, Sardar; Al Madhoun, Ashraf; Ahmad, Zunair; AlMekhled, Dawood; Azim, Rafaat; Al-Kandari, Sarah; Wahid, Maziad Al-Abdul; Al-Mulla, Fahd; Ahmad, Rasheed.
+Institution
+ Al-Rashed, Fatema. Immunology and Microbiology Department, Dasman Diabetes Institute, Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait.
+ Sindhu, Sardar. Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman, Kuwait.
+ Al Madhoun, Ashraf. Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman, Kuwait.
+ Ahmad, Zunair. Royal College of Surgeons in Ireland, Busaiteen, Bahrain.
+ AlMekhled, Dawood. School of Biomedical Sciences, Monash University, Melbourne, Australia.
+ Azim, Rafaat. Royal College of Surgeons in Ireland, Busaiteen, Bahrain.
+ Al-Kandari, Sarah. Immunology and Microbiology Department, Dasman Diabetes Institute, Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait.
+ Wahid, Maziad Al-Abdul. Royal College of Surgeons in Ireland, Dublin, Ireland.
+ Al-Mulla, Fahd. Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman, Kuwait.
+ Ahmad, Rasheed. Immunology and Microbiology Department, Dasman Diabetes Institute, Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait. rasheed.ahmad@dasmaninstitute.org.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases/pp [Physiopathology]
+ Female
+ *Heart Rate/ph [Physiology]
+ Humans
+ *Inflammation/pp [Physiopathology]
+ Inflammation Mediators/me [Metabolism]
+ Leukocytes/pa [Pathology]
+ Linear Models
+ Male
+ Monocytes/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Phenotype
+ *Rest/ph [Physiology]
+ Risk Factors
+Abstract
+ The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy obese (HO) individuals is not well elucidated. Herein, we investigated the relationship of RHR with expression of leukocyte-inflammatory markers and TLRs in HO individuals. 58-obese and 57-lean participants with no history of a major medical condition, were recruited in this study. In HO individuals, the elevated-RHR correlated positively with diastolic blood pressure, cholesterol, pro-inflammatory monocytes CD11b+CD11c+CD206- phenotype (r = 0.52, P = 0.0003) as well as with activated T cells CD8+HLA-DR+ phenotype (r = 0.27, P = 0.039). No association was found between RHR and the percentage of CD16+CD11b+ neutrophils. Interestingly, elevated RHR positively correlated with cells expressing TLR4 and TLR2 (CD14+TLR4+, r = 0.51, P <= 0.0001; and CD14+TLR2+, r = 0.42, P = 0.001). TLR4+ expressing cells also associated positively with the plasma concentrations of proinflammatory or vascular permeability/matrix modulatory markers including TNF-alpha (r = 0.36, P = 0.005), VEGF (r = 0.47, P = 0.0002), and MMP-9 (r = 0.53, P <= 0.0001). Multiple regression revealed that RHR is independently associated with CD14+TLR4+ monocytes and VEGF. We conclude that in HO individuals, increased CD14+TLR4+ monocytes and circulatory VEGF levels associated independently with RHR, implying that RHR monitoring could be used as a non-invasive clinical indicator to identify healthy obese individuals at an increased risk of developing inflammation and cardiovascular disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-93449-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Rashed&issn=2045-2322&title=Scientific+Reports&atitle=Elevated+resting+heart+rate+as+a+predictor+of+inflammation+and+cardiovascular+risk+in+healthy+obese+individuals.&volume=11&issue=1&spage=13883&epage=&date=2021&doi=10.1038%2Fs41598-021-93449-5&pmid=34230580&sid=OVID:medline
+
+<803>
+Unique Identifier
+ 34228124
+Title
+ Novel Laboratory Index, Based on Fasting Blood Parameters, Accurately Reflects Insulin Sensitivity.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 106(12):e5208-e5221, 2021 11 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karczewska-Kupczewska M; Nikolajuk A; Stefanowicz M; Matulewicz N; Arnoriaga-Rodriguez M; Fernandez-Real JM; Straczkowski M
+Author NameID
+ Karczewska-Kupczewska, Monika; ORCID: https://orcid.org/0000-0003-1396-4290
+Authors Full Name
+ Karczewska-Kupczewska, Monika; Nikolajuk, Agnieszka; Stefanowicz, Magdalena; Matulewicz, Natalia; Arnoriaga-Rodriguez, Maria; Fernandez-Real, Jose Manuel; Straczkowski, Marek.
+Institution
+ Karczewska-Kupczewska, Monika. Department of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, 15-276 Bialystok, Poland.
+ Nikolajuk, Agnieszka. Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
+ Stefanowicz, Magdalena. Department of Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland.
+ Matulewicz, Natalia. Department of Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland.
+ Arnoriaga-Rodriguez, Maria. Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital; Department of Medical Sciences, Faculty of Medicine, University of Girona; and CIBERobn Pathophysiology of Obesity and Nutrition, Girona, Spain.
+ Fernandez-Real, Jose Manuel. Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital; Department of Medical Sciences, Faculty of Medicine, University of Girona; and CIBERobn Pathophysiology of Obesity and Nutrition, Girona, Spain.
+ Straczkowski, Marek. Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/an [Analysis]
+ Cohort Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Fasting
+ Female
+ Follow-Up Studies
+ Glucose Clamp Technique
+ Glucose Tolerance Test
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ *Laboratories/sn [Statistics & Numerical Data]
+ Male
+ *Obesity/pp [Physiopathology]
+ Prediabetic State/bl [Blood]
+ *Prediabetic State/di [Diagnosis]
+ Prognosis
+ Young Adult
+Keyword Heading
+ biomarker
+ hyperinsulinemic-euglycemic clamp
+ indirect indices
+ insulin resistance
+ insulin sensitivity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Simple and reliable measurement of insulin sensitivity may be important for the prevention of insulin-resistance-related diseases. Surrogate indices of insulin sensitivity are of limited utility in population without signs of metabolic syndrome.
+
+ OBJECTIVE: The aim of our study was to provide simple and accurate index of insulin sensitivity.
+
+ DESIGN: The study group comprised 150 young healthy participants. Hyperinsulinemic-euglycemic clamp was performed. Regression models with different laboratory parameters were constructed. Validation cohort 1 comprised independent group of 110 subjects, including individuals with prediabetes and newly diagnosed type 2 diabetes. Validation cohort 2 comprised 38 obese subjects before and after diet-induced weight loss. Validation cohort 3 comprised 60 nondiabetic subjects from an independent center.
+
+ RESULTS: The supervised principal component model established optimal set of variables correlated with insulin sensitivity. This model (Fasting Laboratory Assessment of Insulin Sensitivity [FLAIS]) used red blood cell count, alanine aminotransferase activity, serum C-peptide, SHBG, IGF-binding protein 1, and adiponectin concentrations. FLAIS exhibited strong correlation with clamp-derived insulin sensitivity. The sensitivity of the model was 90% and the specificity was 68%. In validation cohort 1, differences in FLAIS among the groups paralleled those observed with the clamp, with the lowest values in prediabetes and diabetes. In validation cohort 2, FLAIS reflected the change in insulin sensitivity after weight loss. The main findings were confirmed in validation cohort 3.
+
+ CONCLUSION: We provide simple and accurate method of assessing insulin sensitivity, which allows to identify insulin resistance even in the population without overt metabolic disturbances. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1210%2fclinem%2fdgab489
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karczewska-Kupczewska&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Novel+Laboratory+Index%2C+Based+on+Fasting+Blood+Parameters%2C+Accurately+Reflects+Insulin+Sensitivity.&volume=106&issue=12&spage=e5208&epage=e5221&date=2021&doi=10.1210%2Fclinem%2Fdgab489&pmid=34228124&sid=OVID:medline
+
+<804>
+Unique Identifier
+ 34226119
+Title
+ Associations between obesity indices and both type 2 diabetes and impaired fasting glucose among West African adults: Results from WHO STEPS surveys.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(9):2652-2660, 2021 08 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Issaka A; Cameron AJ; Paradies Y; Kiwallo JB; Bosu WK; Houehanou YCN; Wesseh CS; Houinato DS; Nazoum DJP; Stevenson C
+Authors Full Name
+ Issaka, Ayuba; Cameron, Adrian J; Paradies, Yin; Kiwallo, Jean B; Bosu, William K; Houehanou, Yessito Corine N; Wesseh, Chea S; Houinato, Dismand S; Nazoum, Diarra J P; Stevenson, Christopher.
+Institution
+ Issaka, Ayuba. School of Health and Social Development, Faculty of Health, Deakin University, Geelong, Waurn Ponds Campus, Locked Bag 20000, Geelong, VIC, 3220, Australia; Alfred Deakin Institute for Citizenship and Globalisation, Faculty of Arts and Education, Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125, Australia. Electronic address: aissaka@deakin.edu.au.
+ Cameron, Adrian J. School of Health and Social Development, Faculty of Health, Deakin University, Geelong, Waurn Ponds Campus, Locked Bag 20000, Geelong, VIC, 3220, Australia. Electronic address: Adrian.cameron@deakin.edu.au.
+ Paradies, Yin. Alfred Deakin Institute for Citizenship and Globalisation, Faculty of Arts and Education, Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125, Australia. Electronic address: yin.paradies@deakin.edu.au.
+ Kiwallo, Jean B. Directorate of Population Health Protection (DPSP) of the Burkina Faso, Ministry of Health, Ouagadougou, Burkina Faso. Electronic address: dr_kiwallo@yahoo.fr.
+ Bosu, William K. West Africa Health Organization, 01 BP 153, Bobo-Dioulasso, Burkina Faso. Electronic address: wbosu@wahooas.org.
+ Houehanou, Yessito Corine N. National School of Senior Technicians Training in Public Health and Epidemiological Surveillance, University of Parakou, Postal Box 122, Parakou, Benin. Electronic address: dshouinato@gmail.com.
+ Wesseh, Chea S. Ministry of Health, Republic of Liberia, Congo Town, Monrovia, Liberia. Electronic address: cswesseh@yahoo.com.
+ Houinato, Dismand S. Laboratory of Epidemiology of Chronic and Neurological Diseases (LEMACEN), Faculty of Health Sciences, 01 Postal Box 188 Cotonou, University of Abomey Calavi, Cotonou, Benin. Electronic address: yessito_fr@yahoo.fr.
+ Nazoum, Diarra J P. Former Head of Noncommunicable Diseases, National Directorate of Health, Ministry of Health and Public Hygiene, Bomako, Mali. Electronic address: dnazoum@yahoo.fr.
+ Stevenson, Christopher. School of Health and Social Development, Faculty of Health, Deakin University, Geelong, Waurn Ponds Campus, Locked Bag 20000, Geelong, VIC, 3220, Australia. Electronic address: christopher.stevenson@deakin.edu.au.
+MeSH Subject Headings
+ Adult
+ Africa, Western/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ Black People
+ *Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ Glucose Metabolism Disorders/bl [Blood]
+ *Glucose Metabolism Disorders/di [Diagnosis]
+ Glucose Metabolism Disorders/ep [Epidemiology]
+ Health Surveys
+ Humans
+ Male
+ Middle Aged
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Predictive Value of Tests
+ Risk Assessment
+ Risk Factors
+ *Waist Circumference
+ *Waist-Hip Ratio
+ World Health Organization
+Keyword Heading
+ Impaired fasting glucose
+ Obesity indices
+ Type 2 diabetes
+ West Africa
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: Various obesity indices such as BMI, waist circumference (WC), waist-hip ratio, (WHR) and waist-to-height ratio (WHtR) are associated with the risk of type 2 Diabetes Mellitus (T2DM). Given few studies examining the strength of the association in this population, we aimed to identify which obesity indices are most strongly associated with T2DM and impaired fasting glucose (IFG) among adults from five West African countries.
+
+ METHODS AND RESULTS: Data from 15,520 participants from the World Health Organisation (WHO) STEPs surveys in Burkina Faso, Benin, Mali, Liberia, and Ghana were included in analyses. Multinomial logistic regression was used to calculate the relative risk (RR) per standard deviation (SD) of each anthropometric measure, modelled as both continuous variables and as categorical variables based on established cut-points. In the analyses with continuous variables, the unadjusted RRs for T2DM per SD were 1.30 (1.23, 1.37) for body mass index (BMI); 1.56 (1.46, 1.67) for WC; 2.57 (2.15, 3.09) for WHtR and 1.16 (1.03, 1.31) for WHR. WHtR showed the strongest association with T2DM in all adjusted analyses. For models using categorical variables based on established cut-points, obesity defined using waist circumference (OB-WC) and OB-BMI showed the strongest associations with T2DM, and OB-WHR, the weakest association in all adjusted analyses.
+
+ CONCLUSION: WHtR and WC appear to be the indices most strongly associated with T2DM and IFG respectively. Given its simplicity, WC may be the metric that most usefully conveys risk for T2DM in West African adults. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.05.028
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Issaka&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Associations+between+obesity+indices+and+both+type+2+diabetes+and+impaired+fasting+glucose+among+West+African+adults%3A+Results+from+WHO+STEPS+surveys.&volume=31&issue=9&spage=2652&epage=2660&date=2021&doi=10.1016%2Fj.numecd.2021.05.028&pmid=34226119&sid=OVID:medline
+
+<805>
+Unique Identifier
+ 34219465
+Title
+ Cardiovascular Biomarkers of Obesity and Overlap With Cardiometabolic Dysfunction.
+Source
+ Journal of the American Heart Association. 10(14):e020215, 2021 07 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lau ES; Paniagua SM; Zarbafian S; Hoffman U; Long MT; Hwang SJ; Courchesne P; Yao C; Ma J; Larson MG; Levy D; Shah RV; Ho JE
+Authors Full Name
+ Lau, Emily S; Paniagua, Samantha M; Zarbafian, Shahrooz; Hoffman, Udo; Long, Michelle T; Hwang, Shih-Jen; Courchesne, Paul; Yao, Chen; Ma, Jiantao; Larson, Martin G; Levy, Daniel; Shah, Ravi V; Ho, Jennifer E.
+Institution
+ Lau, Emily S. Cardiology Division Department of Medicine Massachusetts General Hospital Boston MA.
+ Paniagua, Samantha M. Cardiology Division Department of Medicine Massachusetts General Hospital Boston MA.
+ Paniagua, Samantha M. Cardiovascular Research Center Massachusetts General Hospital Boston MA.
+ Zarbafian, Shahrooz. Cardiology Division Department of Medicine Massachusetts General Hospital Boston MA.
+ Zarbafian, Shahrooz. Cardiovascular Research Center Massachusetts General Hospital Boston MA.
+ Hoffman, Udo. Department of Radiology Massachusetts General Hospital Boston MA.
+ Long, Michelle T. Section of Gastroenterology Boston Medical CenterBoston University School of Medicine Boston MA.
+ Hwang, Shih-Jen. Department of Biostatistics Boston University School of Public Health Boston MA.
+ Hwang, Shih-Jen. The Framingham Heart Study Framingham MA.
+ Courchesne, Paul. The Framingham Heart Study Framingham MA.
+ Yao, Chen. The Framingham Heart Study Framingham MA.
+ Yao, Chen. The Population Sciences Branch Division of Intramural Research National Heart, Lung, and Blood InstituteNational Institutes of Health Bethesda MD.
+ Ma, Jiantao. The Framingham Heart Study Framingham MA.
+ Ma, Jiantao. The Population Sciences Branch Division of Intramural Research National Heart, Lung, and Blood InstituteNational Institutes of Health Bethesda MD.
+ Larson, Martin G. Department of Biostatistics Boston University School of Public Health Boston MA.
+ Larson, Martin G. The Framingham Heart Study Framingham MA.
+ Levy, Daniel. The Framingham Heart Study Framingham MA.
+ Levy, Daniel. The Population Sciences Branch Division of Intramural Research National Heart, Lung, and Blood InstituteNational Institutes of Health Bethesda MD.
+ Shah, Ravi V. Cardiology Division Department of Medicine Massachusetts General Hospital Boston MA.
+ Shah, Ravi V. Cardiovascular Research Center Massachusetts General Hospital Boston MA.
+ Ho, Jennifer E. Cardiology Division Department of Medicine Massachusetts General Hospital Boston MA.
+ Ho, Jennifer E. Cardiovascular Research Center Massachusetts General Hospital Boston MA.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Aged
+ *Biomarkers/bl [Blood]
+ Female
+ Humans
+ Insulin Resistance
+ Logistic Models
+ Male
+ Metabolic Networks and Pathways
+ *Metabolic Syndrome/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Phenotype
+ *Proteomics
+ Risk Factors
+Keyword Heading
+ biomarkers
+ cardiometabolic disease
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Obesity may be associated with a range of cardiometabolic manifestations. We hypothesized that proteomic profiling may provide insights into the biological pathways that contribute to various obesity-associated cardiometabolic traits. We sought to identify proteomic signatures of obesity and examine overlap with related cardiometabolic traits, including abdominal adiposity, insulin resistance, and adipose depots. Methods and Results We measured 71 circulating cardiovascular disease protein biomarkers in 6981 participants (54% women; mean age, 49 years). We examined the associations of obesity, computed tomography measures of adiposity, cardiometabolic traits, and incident metabolic syndrome with biomarkers using multivariable regression models. Of the 71 biomarkers examined, 45 were significantly associated with obesity, of which 32 were positively associated and 13 were negatively associated with obesity (false discovery rate q<0.05 for all). There was significant overlap of biomarker profiles of obesity and cardiometabolic traits, but 23 biomarkers, including melanoma cell adhesion molecule (MCAM), growth differentiation factor-15 (GDF15), and lipoprotein(a) (LPA) were unique to metabolic traits only. Using hierarchical clustering, we found that the protein biomarkers clustered along 3 main trait axes: adipose, metabolic, and lipid traits. In longitudinal analyses, 6 biomarkers were significantly associated with incident metabolic syndrome: apolipoprotein B (apoB), insulin-like growth factor-binding protein 2 (IGFBP2), plasma kallikrein (KLKB1), complement C2 (C2), fibrinogen (FBN), and N-terminal pro-B-type natriuretic peptide (NT-proBNP); false discovery rate q<0.05 for all. Conclusions We found that the proteomic architecture of obesity overlaps considerably with associated cardiometabolic traits, implying shared pathways. Despite overlap, hierarchical clustering of proteomic profiles identified 3 distinct clusters of cardiometabolic traits: adipose, metabolic, and lipid. Further exploration of these novel protein targets and associated pathways may provide insight into the mechanisms responsible for the progression from obesity to cardiometabolic disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1161%2fJAHA.120.020215
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lau&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Cardiovascular+Biomarkers+of+Obesity+and+Overlap+With+Cardiometabolic+Dysfunction.&volume=10&issue=14&spage=e020215&epage=&date=2021&doi=10.1161%2FJAHA.120.020215&pmid=34219465&sid=OVID:medline
+
+<806>
+Unique Identifier
+ 34215499
+Title
+ Comparison of aggressive versus standard intravenous hydration for clinical improvement among patients with mild acute pancreatitis: A randomized controlled trial.
+Source
+ Pancreatology. 21(7):1224-1230, 2021 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Angsubhakorn A; Tipchaichatta K; Chirapongsathorn S
+Authors Full Name
+ Angsubhakorn, Apirat; Tipchaichatta, Krit; Chirapongsathorn, Sakkarin.
+Institution
+ Angsubhakorn, Apirat. Division of Gastroenterology and Hepatology, Department of Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.
+ Tipchaichatta, Krit. Division of Gastroenterology and Hepatology, Department of Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.
+ Chirapongsathorn, Sakkarin. Division of Gastroenterology and Hepatology, Department of Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand. Electronic address: sakkarin.chi@pcm.ac.th.
+MeSH Subject Headings
+ Administration, Intravenous
+ Adult
+ Biomarkers/bl [Blood]
+ Dose-Response Relationship, Drug
+ Female
+ *Fluid Therapy/mt [Methods]
+ Humans
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Pancreatitis/bl [Blood]
+ Pancreatitis/co [Complications]
+ Pancreatitis/th [Therapy]
+ *Pancreatitis
+ Prospective Studies
+ *Ringer's Lactate/ad [Administration & Dosage]
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ Acute pancreatitis
+ Aggressive intravenous hydration
+ Lactated ringer
+ Obese
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Controversy remains regarding fluid management strategy, optimal volume and rate of intravenous fluid in mild acute pancreatitis. We performed a randomized controlled trial to compare clinical improvement and inflammatory markers between aggressive and standard fluid management.
+
+ METHODS: A single center prospective randomized controlled trial was conducted in a tertiary care hospital. We randomized patients with a diagnosis of mild acute pancreatitis using revised Atlanta classification in two groups, the aggressive (20 ml/kg bolus followed by 3 ml/kg/hr) and standard (10 ml/kg bolus followed by 1.5 ml/kg/hr) intravenous hydration with Lactated Ringer's solution. Primary outcome was clinical improvement at 24 and 36 hours.
+
+ RESULTS: The mean age of patients was 46 years and 34 patients (77%) were male. The average volumes of fluid during the first 24 hours in aggressive and standard groups was 4886 ml (71 ml/kg) and 3985 ml (53 ml/kg), respectively; p-value 0.002. Aggressive intravenous hydration did not significantly improve clinical outcome compared with standard intravenous hydration (45.45% vs. 31.82%, respectively; p-value 0.353). However, subgroup analysis between patients with obese and non-obese status, revealed aggressive intravenous hydration significantly improved clinical outcome within the first 24 hours in obese group.
+
+ CONCLUSION: Aggressive intravenous hydration with Lactated Ringer's solution did not improve clinical outcome in mild acute pancreatitis but showed statistically significant improvement only in patients with obese status. Future studies should include a larger sample size to confirm these findings. Copyright © 2021 IAP and EPC. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ringer's Lactate).
+Publication Type
+ Comparative Study. Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.pan.2021.06.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Angsubhakorn&issn=1424-3903&title=Pancreatology&atitle=Comparison+of+aggressive+versus+standard+intravenous+hydration+for+clinical+improvement+among+patients+with+mild+acute+pancreatitis%3A+A+randomized+controlled+trial.&volume=21&issue=7&spage=1224&epage=1230&date=2021&doi=10.1016%2Fj.pan.2021.06.004&pmid=34215499&sid=OVID:medline
+
+<807>
+Unique Identifier
+ 34211180
+Title
+ Intestinal MYC modulates obesity-related metabolic dysfunction.
+Source
+ Nature Metabolism. 3(7):923-939, 2021 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Luo Y; Yang S; Wu X; Takahashi S; Sun L; Cai J; Krausz KW; Guo X; Dias HB; Gavrilova O; Xie C; Jiang C; Liu W; Gonzalez FJ
+Author NameID
+ Luo, Yuhong; ORCID: http://orcid.org/0000-0001-8273-8380
+ Takahashi, Shogo; ORCID: http://orcid.org/0000-0002-3831-5353
+ Sun, Lulu; ORCID: http://orcid.org/0000-0001-8876-5099
+ Jiang, Changtao; ORCID: http://orcid.org/0000-0002-5206-2372
+ Liu, Weiwei; ORCID: http://orcid.org/0000-0001-5069-9727
+ Gonzalez, Frank J; ORCID: http://orcid.org/0000-0002-7990-2140
+Authors Full Name
+ Luo, Yuhong; Yang, Shoumei; Wu, Xuan; Takahashi, Shogo; Sun, Lulu; Cai, Jie; Krausz, Kristopher W; Guo, Xiaozhen; Dias, Henrique B; Gavrilova, Oksana; Xie, Cen; Jiang, Changtao; Liu, Weiwei; Gonzalez, Frank J.
+Institution
+ Luo, Yuhong. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
+ Yang, Shoumei. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
+ Wu, Xuan. Department of Laboratory Medicine and Central Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, P.R. China.
+ Wu, Xuan. Department of Laboratory Medicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, P.R. China.
+ Takahashi, Shogo. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
+ Takahashi, Shogo. Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA.
+ Sun, Lulu. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
+ Cai, Jie. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
+ Krausz, Kristopher W. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
+ Guo, Xiaozhen. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China.
+ Dias, Henrique B. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
+ Gavrilova, Oksana. Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
+ Xie, Cen. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
+ Xie, Cen. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China.
+ Jiang, Changtao. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, P.R. China.
+ Liu, Weiwei. Department of Laboratory Medicine and Central Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, P.R. China. hsvivian@tongji.edu.cn.
+ Liu, Weiwei. Department of Laboratory Medicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, P.R. China. hsvivian@tongji.edu.cn.
+ Gonzalez, Frank J. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. gonzalef@mail.nih.gov.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Diet, High-Fat
+ Disease Models, Animal
+ Disease Susceptibility
+ Glucagon-Like Peptide 1/me [Metabolism]
+ Humans
+ Ilium/me [Metabolism]
+ Insulin Resistance
+ *Intestinal Mucosa/me [Metabolism]
+ Mice
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Proto-Oncogene Proteins c-myc/ai [Antagonists & Inhibitors]
+ Proto-Oncogene Proteins c-myc/ge [Genetics]
+ *Proto-Oncogene Proteins c-myc/me [Metabolism]
+Abstract
+ MYC is a transcription factor with broad biological functions, notably in the control of cell proliferation. Here, we show that intestinal MYC regulates systemic metabolism. We find that MYC expression is increased in ileum biopsies from individuals with obesity and positively correlates with body mass index. Intestine-specific reduction of MYC in mice improves high-fat-diet-induced obesity, insulin resistance, hepatic steatosis and steatohepatitis. Mechanistically, reduced expression of MYC in the intestine promotes glucagon-like peptide-1 (GLP-1) production and secretion. Moreover, we identify Cers4, encoding ceramide synthase 4, catalysing de novo ceramide synthesis, as a MYC target gene. Finally, we show that administration of the MYC inhibitor 10058-F4 has beneficial effects on high-fat-diet-induced metabolic disorders, and is accompanied by increased GLP-1 and reduced ceramide levels in serum. This study positions intestinal MYC as a putative drug target against metabolic diseases, including non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Copyright © 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MYC protein, human). 0 (Proto-Oncogene Proteins c-myc). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Journal Article. Research Support, N.I.H., Intramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs42255-021-00421-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Luo&issn=2522-5812&title=Nature+Metabolism&atitle=Intestinal+MYC+modulates+obesity-related+metabolic+dysfunction.&volume=3&issue=7&spage=923&epage=939&date=2021&doi=10.1038%2Fs42255-021-00421-8&pmid=34211180&sid=OVID:medline
+
+<808>
+Unique Identifier
+ 34208585
+Title
+ Impaired Leptin Signalling in Obesity: Is Leptin a New Thermolipokine?. [Review]
+Source
+ International Journal of Molecular Sciences. 22(12), 2021 Jun 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Genchi VA; D'Oria R; Palma G; Caccioppoli C; Cignarelli A; Natalicchio A; Laviola L; Giorgino F; Perrini S
+Author NameID
+ Genchi, Valentina Annamaria; ORCID: https://orcid.org/0000-0001-8188-9638
+ Cignarelli, Angelo; ORCID: https://orcid.org/0000-0001-6477-9031
+ Natalicchio, Annalisa; ORCID: https://orcid.org/0000-0002-6131-7517
+ Giorgino, Francesco; ORCID: https://orcid.org/0000-0001-7372-2678
+Authors Full Name
+ Genchi, Valentina Annamaria; D'Oria, Rossella; Palma, Giuseppe; Caccioppoli, Cristina; Cignarelli, Angelo; Natalicchio, Annalisa; Laviola, Luigi; Giorgino, Francesco; Perrini, Sebastio.
+Institution
+ Genchi, Valentina Annamaria. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+ D'Oria, Rossella. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+ Palma, Giuseppe. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+ Caccioppoli, Cristina. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+ Cignarelli, Angelo. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+ Natalicchio, Annalisa. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+ Laviola, Luigi. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+ Giorgino, Francesco. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+ Perrini, Sebastio. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Body Temperature Regulation
+ Disease Management
+ Disease Susceptibility
+ Energy Metabolism
+ Humans
+ Hypothalamus/me [Metabolism]
+ Leptin/bl [Blood]
+ Leptin/df [Deficiency]
+ *Leptin/me [Metabolism]
+ Obesity/di [Diagnosis]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/th [Therapy]
+ *Signal Transduction
+ Thermogenesis
+ Treatment Outcome
+Keyword Heading
+ adiposity
+ brown adipose tissue
+ hyperleptinaemia
+ leptin
+ leptin-resistance
+ obesity
+ thermogenesis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Leptin is a principal adipose-derived hormone mostly implicated in the regulation of energy balance through the activation of anorexigenic neuronal pathways. Comprehensive studies have established that the maintenance of certain concentrations of circulating leptin is essential to avoid an imbalance in nutrient intake. Indeed, genetic modifications of the leptin/leptin receptor axis and the obesogenic environment may induce changes in leptin levels or action in a manner that accelerates metabolic dysfunctions, resulting in a hyperphagic status and adipose tissue expansion. As a result, a vicious cycle begins wherein hyperleptinaemia and leptin resistance occur, in turn leading to increased food intake and fat enlargement, which is followed by leptin overproduction. In addition, in the context of obesity, a defective thermoregulatory response is associated with impaired leptin signalling overall within the ventromedial nucleus of the hypothalamus. These recent findings highlight the role of leptin in the regulation of adaptive thermogenesis, thus suggesting leptin to be potentially considered as a new thermolipokine. This review provides new insight into the link between obesity, hyperleptinaemia, leptin resistance and leptin deficiency, focusing on the ability to restore leptin sensitiveness by way of enhanced thermogenic responses and highlighting novel anti-obesity therapeutic strategies.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22126445
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Genchi&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Impaired+Leptin+Signalling+in+Obesity%3A+Is+Leptin+a+New+Thermolipokine%3F.&volume=22&issue=12&spage=6445&epage=&date=2021&doi=10.3390%2Fijms22126445&pmid=34208585&sid=OVID:medline
+
+<809>
+Unique Identifier
+ 34206460
+Title
+ Clozapine Worsens Glucose Intolerance, Nonalcoholic Fatty Liver Disease, Kidney Damage, and Retinal Injury and Increases Renal Reactive Oxygen Species Production and Chromium Loss in Obese Mice.
+Source
+ International Journal of Molecular Sciences. 22(13), 2021 Jun 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chang GR; Liu HY; Yang WC; Wang CM; Wu CF; Lin JW; Lin WL; Wang YC; Lin TC; Liao HJ; Hou PH; Chan CH; Lin CF
+Author NameID
+ Chang, Geng-Ruei; ORCID: https://orcid.org/0000-0003-0577-3339
+ Wang, Chao-Min; ORCID: https://orcid.org/0000-0002-8954-6151
+Authors Full Name
+ Chang, Geng-Ruei; Liu, Hsien-Yueh; Yang, Wei-Cheng; Wang, Chao-Min; Wu, Ching-Fen; Lin, Jen-Wei; Lin, Wei-Li; Wang, Yu-Chen; Lin, Tzu-Chun; Liao, Huei-Jyuan; Hou, Po-Hsun; Chan, Chee-Hong; Lin, Chuen-Fu.
+Institution
+ Chang, Geng-Ruei. Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 600023, Taiwan.
+ Liu, Hsien-Yueh. Bachelor Degree Program in Animal Healthcare, Hungkuang University, 6 Section, 1018 Taiwan Boulevard, Shalu District, Taichung 433304, Taiwan.
+ Yang, Wei-Cheng. School of Veterinary Medicine, National Taiwan University, 4 Section, 1 Roosevelt Road, Taipei 100046, Taiwan.
+ Wang, Chao-Min. Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 600023, Taiwan.
+ Wu, Ching-Fen. Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 600023, Taiwan.
+ Lin, Jen-Wei. Bachelor Degree Program in Animal Healthcare, Hungkuang University, 6 Section, 1018 Taiwan Boulevard, Shalu District, Taichung 433304, Taiwan.
+ Lin, Wei-Li. Bachelor Degree Program in Animal Healthcare, Hungkuang University, 6 Section, 1018 Taiwan Boulevard, Shalu District, Taichung 433304, Taiwan.
+ Lin, Wei-Li. General Education Center, Chaoyang University of Technology, 168 Jifeng Eastern Road, Taichung 413310, Taiwan.
+ Wang, Yu-Chen. Division of Cardiology, Asia University Hospital, 222 Fuxin Road, Wufeng District, Taichung 413505, Taiwan.
+ Wang, Yu-Chen. Department of Medical Laboratory Science and Biotechnology, Asia University, 500 Lioufeng Road, Wufeng District, Taichung 413305, Taiwan.
+ Wang, Yu-Chen. Division of Cardiovascular Medicine, China Medical University Hospital, 2 Yude Road, North District, Taichung 404332, Taiwan.
+ Wang, Yu-Chen. College of Medicine, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 404333, Taiwan.
+ Lin, Tzu-Chun. Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 600023, Taiwan.
+ Liao, Huei-Jyuan. Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 600023, Taiwan.
+ Hou, Po-Hsun. Department of Psychiatry, Taichung Veterans General Hospital, 4 Section, 1650 Taiwan Boulevard, Taichung 407219, Taiwan.
+ Hou, Po-Hsun. Faculty of Medicine, National Yang Ming Chiao Tung University, 2 Section, 155 Linong Street, Beitou District, Taipei 112304, Taiwan.
+ Chan, Chee-Hong. Division of Nephrology, Chang Bing Show Chwan Memorial Hospital, 6 Lugong Road, Lukang Township, Changhua 505029, Taiwan.
+ Lin, Chuen-Fu. Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, 1 Shuefu Road, Neipu, Pingtung 912301, Taiwan.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Animals
+ Biomarkers
+ Body Weights and Measures
+ *Chromium/df [Deficiency]
+ *Clozapine/pd [Pharmacology]
+ Disease Models, Animal
+ Fatty Acid-Binding Proteins/ge [Genetics]
+ Fluorescent Antibody Technique
+ Gene Expression
+ Gene Expression Regulation
+ *Glucose Intolerance/me [Metabolism]
+ Immunohistochemistry
+ Insulin/me [Metabolism]
+ Kidney Diseases/et [Etiology]
+ *Kidney Diseases/me [Metabolism]
+ Liver/me [Metabolism]
+ Mice
+ Mice, Obese
+ Nitric Oxide Synthase Type II
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Proto-Oncogene Proteins c-akt/me [Metabolism]
+ Reactive Oxygen Species/me [Metabolism]
+ Retinal Diseases/et [Etiology]
+ *Retinal Diseases/me [Metabolism]
+ Sterol Regulatory Element Binding Protein 1/ge [Genetics]
+Keyword Heading
+ chromium
+ clozapine
+ fatty liver disease
+ glucose intolerance
+ obesity
+ reactive oxygen species
+ renal damage
+ retinal injury
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Clozapine is widely employed in the treatment of schizophrenia. Compared with that of atypical first-generation antipsychotics, atypical second-generation antipsychotics such as clozapine have less severe side effects and may positively affect obesity and blood glucose level. However, no systematic study of clozapine's adverse metabolic effects-such as changes in kidney and liver function, body weight, glucose and triglyceride levels, and retinopathy-was conducted. This research investigated how clozapine affects weight, the bodily distribution of chromium, liver damage, fatty liver scores, glucose homeostasis, renal impairment, and retinopathy in mice fed a high fat diet (HFD). We discovered that obese mice treated with clozapine gained more weight and had greater kidney, liver, and retroperitoneal and epididymal fat pad masses; higher daily food efficiency; higher serum or hepatic triglyceride, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and creatinine levels; and higher hepatic lipid regulation marker expression than did the HFD-fed control mice. Furthermore, the clozapine group mice exhibited insulin resistance, poorer insulin sensitivity, greater glucose intolerance, and less Akt phosphorylation; their GLUT4 expression was lower, they had renal damage, more reactive oxygen species, and IL-1 expression, and, finally, their levels of antioxidative enzymes (superoxide dismutase, glutathione peroxidase, and catalase) were lower. Moreover, clozapine reduced the thickness of retinal cell layers and increased iNOS and NF-kappaB expression; a net negative chromium balance occurred because more chromium was excreted through urine, and this influenced chromium mobilization, which did not help overcome the hyperglycemia. Our clozapine group had considerably higher fatty liver scores, which was supported by the findings of lowered adiponectin protein levels and increased FASN protein, PNPLA3 protein, FABP4 mRNA, and SREBP1 mRNA levels. We conclude that clozapine can worsen nonalcoholic fatty liver disease, diabetes, and kidney and retinal injury. Therefore, long-term administration of clozapine warrants higher attention.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FABP4 protein, human). 0 (Fatty Acid-Binding Proteins). 0 (Insulin). 0 (Reactive Oxygen Species). 0 (SREBF1 protein, human). 0 (Sterol Regulatory Element Binding Protein 1). 0R0008Q3JB (Chromium). EC 1-14-13-39 (NOS2 protein, human). EC 1-14-13-39 (Nitric Oxide Synthase Type II). EC 2-7-11-1 (Proto-Oncogene Proteins c-akt). J60AR2IKIC (Clozapine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22136680
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chang&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Clozapine+Worsens+Glucose+Intolerance%2C+Nonalcoholic+Fatty+Liver+Disease%2C+Kidney+Damage%2C+and+Retinal+Injury+and+Increases+Renal+Reactive+Oxygen+Species+Production+and+Chromium+Loss+in+Obese+Mice.&volume=22&issue=13&spage=6680&epage=&date=2021&doi=10.3390%2Fijms22136680&pmid=34206460&sid=OVID:medline
+
+<810>
+Unique Identifier
+ 34177920
+Title
+ Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides.
+Source
+ Frontiers in Immunology. 12:678360, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Beisner J; Filipe Rosa L; Kaden-Volynets V; Stolzer I; Gunther C; Bischoff SC
+Authors Full Name
+ Beisner, Julia; Filipe Rosa, Louisa; Kaden-Volynets, Valentina; Stolzer, Iris; Gunther, Claudia; Bischoff, Stephan C.
+Institution
+ Beisner, Julia. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+ Filipe Rosa, Louisa. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+ Kaden-Volynets, Valentina. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+ Stolzer, Iris. Medical Clinic 1, University Hospital Erlangen, Friedrich Alexander University, Erlangen, Germany.
+ Gunther, Claudia. Medical Clinic 1, University Hospital Erlangen, Friedrich Alexander University, Erlangen, Germany.
+ Bischoff, Stephan C. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+MeSH Subject Headings
+ Animal Feed
+ Animals
+ Biomarkers
+ *Butyric Acid/pd [Pharmacology]
+ Dietary Supplements
+ Disease Models, Animal
+ Female
+ Gastrointestinal Microbiome/de [Drug Effects]
+ *Intestinal Mucosa/de [Drug Effects]
+ *Intestinal Mucosa/me [Metabolism]
+ *Inulin/ad [Administration & Dosage]
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Mice
+ Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Permeability
+ *Pore Forming Cytotoxic Proteins/bi [Biosynthesis]
+ *Prebiotics/ad [Administration & Dosage]
+ Tight Junctions/me [Metabolism]
+Keyword Heading
+ NAFLD
+ antimicrobial peptides
+ butyrate
+ defensin
+ innate immunity
+ inulin
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Defects in the mucosal barrier have been associated with metabolic diseases such as obesity and non-alcoholic fatty liver disease (NAFLD). Mice fed a Western-style diet (WSD) develop obesity and are characterized by a diet-induced intestinal barrier dysfunction, bacterial endotoxin translocation and subsequent liver steatosis. To examine whether inulin or sodium butyrate could improve gut barrier dysfunction, C57BL/6 mice were fed a control diet or a WSD +/- fructose supplemented with either 10% inulin or 5% sodium butyrate for 12 weeks respectively. Inulin and sodium butyrate attenuated hepatosteatitis in the WSD-induced obesity mouse model by reducing weight gain, liver weight, plasma and hepatic triglyceride level. Furthermore, supplementation with inulin or sodium butyrate induced expression of Paneth cell alpha-defensins and matrix metalloproteinase-7 (MMP7), which was impaired by the WSD and particularly the fructose-added WSD. Effects on antimicrobial peptide function in the ileum were accompanied by induction of beta-defensin-1 and tight junction genes in the colon resulting in improved intestinal permeability and endotoxemia. Organoid culture of small intestinal crypts revealed that the short chain fatty acids (SCFA) butyrate, propionate and acetate, fermentation products of inulin, induce Paneth cell alpha-defensin expression in vitro, and that histone deacetylation and STAT3 might play a role in butyrate-mediated induction of alpha-defensins. In summary, inulin and sodium butyrate attenuate diet-induced barrier dysfunction and induce expression of Paneth cell antimicrobials. The administration of prebiotic fiber or sodium butyrate could be an interesting therapeutic approach to improve diet-induced obesity. Copyright © 2021 Beisner, Filipe Rosa, Kaden-Volynets, Stolzer, Gunther and Bischoff.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Pore Forming Cytotoxic Proteins). 0 (Prebiotics). 107-92-6 (Butyric Acid). 9005-80-5 (Inulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffimmu.2021.678360
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Beisner&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Prebiotic+Inulin+and+Sodium+Butyrate+Attenuate+Obesity-Induced+Intestinal+Barrier+Dysfunction+by+Induction+of+Antimicrobial+Peptides.&volume=12&issue=&spage=678360&epage=&date=2021&doi=10.3389%2Ffimmu.2021.678360&pmid=34177920&sid=OVID:medline
+
+<811>
+Unique Identifier
+ 34176942
+Title
+ Relationships among Bone Metabolic Markers, Body Fat Composition and Carotid Intima-Media Thickness in Premenopausal Obese Women.
+Source
+ Acta Medica Okayama. 75(3):373-379, 2021 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yaylali GF; Dedeoglu O; Topsakal S; Herek D; Senol H
+Authors Full Name
+ Yaylali, Guzin F; Dedeoglu, Ozen; Topsakal, Senay; Herek, Duygu; Senol, Hande.
+Institution
+ Yaylali, Guzin F. Department of Endocrinology and Metabolism, Pamukkale University.
+ Dedeoglu, Ozen. Department ofInternal Medicine, Pamukkale University.
+ Topsakal, Senay. Department of Endocrinology and Metabolism, Pamukkale University.
+ Herek, Duygu. Department of Radiology, Pamukkale University.
+ Senol, Hande. Department of Biostatistics, Pamukkale University.
+MeSH Subject Headings
+ Adipose Tissue/dg [Diagnostic Imaging]
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ *Body Fat Distribution
+ Bone and Bones/me [Metabolism]
+ *Carotid Intima-Media Thickness
+ Case-Control Studies
+ Female
+ Humans
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Osteocalcin/bl [Blood]
+ Premenopause
+ Prospective Studies
+ Ultrasonography
+ Young Adult
+Keyword Heading
+ body fat composition
+ carotid intima-media thickness
+ obesity
+ osteocalcin
+ premenopausal women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Osteocalcin (OC) is inversely related to body fat distribution and fasting glucose levels. We sought to observe the effect of OC on fat distribution and subclinical atherosclerosis as measured by carotid intima-media thickness (CIMT) in premenopausal obese women. In this prospective observational study, totally, 73 premenopausal obese women (aged 17-55 years) and 53 healthy women (aged 20-50 years) with normal weight were included as controls. Anthropometric measurements, total fat and fat ratio, insulin, fasting blood glucose, and OC levels were estimated. Ultrasonography was used to assess fat distribution, and fat thickness was measured in 4 regions. Subcutaneous fat (SCF), visceral fat (VF), and preperitoneal fat (PPF) thicknesses were considerably higher in obese subjects (p<0.01) than healthy controls, while OC levels were significantly lower. No correlation was observed between OC levels and SCF, VF, or PPF. In a multiple regression analysis, OC was significantly positively associated with SCF (p=0.04, Beta=0.284). No associations were observed between OC levels and VF, PPF, or CIMT. A significant association was observed between parathyroid hormone (PTH) and VF (p=0.021, Beta=0.284), and vitamin D levels were inversely associated with VF (p=0.002, r=-0.366). OC levels were lower in premenopausal obese women than normal-weight healthy controls, but OC exhibited no correlation with VF or PPF, and only a weak positive association with SCF. Additionally, VF was positively correlated with PTH and inversely correlated with vitamin D. These results suggest that OC may be an early indicator of lipid accumulation in te subcutaneous area and development of atherosclerosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 104982-03-8 (Osteocalcin).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.18926%2fAMO%2f62233
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yaylali&issn=0386-300X&title=Acta+Medica+Okayama&atitle=Relationships+among+Bone+Metabolic+Markers%2C+Body+Fat+Composition+and+Carotid+Intima-Media+Thickness+in+Premenopausal+Obese+Women.&volume=75&issue=3&spage=373&epage=379&date=2021&doi=10.18926%2FAMO%2F62233&pmid=34176942&sid=OVID:medline
+
+<812>
+Unique Identifier
+ 34168100
+Title
+ Triglyceride regulate ACE2 level through MTHFD1.
+Source
+ Journal of Biosciences. 46, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ma X; Li X; Wan BO; Miao Z
+Authors Full Name
+ Ma, Xiaohua; Li, Xiaojing; Wan, B O; Miao, Zhigang.
+Institution
+ Ma, Xiaohua. Institute of Neuroscience, Soochow University, Suzhou, China.
+MeSH Subject Headings
+ Angiotensin-Converting Enzyme 2/ge [Genetics]
+ *Angiotensin-Converting Enzyme 2/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ COVID-19/et [Etiology]
+ COVID-19/vi [Virology]
+ Cell Line
+ Cell Survival
+ *Diet, High-Fat/ae [Adverse Effects]
+ Formate-Tetrahydrofolate Ligase/ge [Genetics]
+ *Formate-Tetrahydrofolate Ligase/me [Metabolism]
+ *Gene Expression Regulation/de [Drug Effects]
+ Humans
+ Male
+ Methenyltetrahydrofolate Cyclohydrolase/ge [Genetics]
+ *Methenyltetrahydrofolate Cyclohydrolase/me [Metabolism]
+ Methylenetetrahydrofolate Dehydrogenase (NADP)/ge [Genetics]
+ *Methylenetetrahydrofolate Dehydrogenase (NADP)/me [Metabolism]
+ Mice
+ Mice, Inbred C57BL
+ Multifunctional Enzymes/ge [Genetics]
+ *Multifunctional Enzymes/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+ Risk Factors
+ SARS-CoV-2
+ Triglycerides/ad [Administration & Dosage]
+ *Triglycerides/pd [Pharmacology]
+Abstract
+ Obesity has been followed with interest as a risk factor for COVID-19, with triglycerides as one of four common criteria used to define obesity, which have been used to study the mechanism of obesity. In this study, we showed that angiotensin-converting enzyme-2 (ACE2) is widely expressed in the mouse body, including the kidney, spleen, brain, heart, lung, liver, and testis, and that ACE2 levels increased after a high-fat diet. The ACE2 levels were recorded at 0 days, 3 days, 7 days, and 14 days after a high-fat diet, and they increased at 14 days after high-fat diet initiation. In addition, triglyceride levels were also significantly increased at 14 days after high-fat diet initiation, but body weight was not changed. Furthermore, we examined the ACE2 levels in Calu3 cells (a lung cancer cell line) after triglyceride treatment, and the results indicated that ACE2 levels were increased at 25 muM and reached their peak at 200 muM. Finally, we found that the mRNA level of mthfd1 was significantly increased in the high-fat diet group. Given these findings, we hypothesize that triglycerides can regulate the expression of ACE2 and Mthfd1.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Mthfd1 protein, mouse). 0 (Multifunctional Enzymes). 0 (RNA, Messenger). 0 (Triglycerides). EC 1-5-1-5 (Methylenetetrahydrofolate Dehydrogenase (NADP)). EC 3-4-17-23 (Ace2 protein, mouse). EC 3-4-17-23 (Angiotensin-Converting Enzyme 2). EC 3-5-4-9 (Methenyltetrahydrofolate Cyclohydrolase). EC 6-3-4-3 (Formate-Tetrahydrofolate Ligase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&AN=34168100
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ma&issn=0250-5991&title=Journal+of+Biosciences&atitle=Triglyceride+regulate+ACE2+level+through+MTHFD1.&volume=46&issue=&spage=&epage=&date=2021&doi=&pmid=34168100&sid=OVID:medline
+
+<813>
+Unique Identifier
+ 34162026
+Title
+ Evaluation of children with type 1 diabetes mellitus in terms of overweight/obesity in tertiary care hospital.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 34(8):995-1000, 2021 Aug 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bitkin EC; Kara C; Yilmaz GC; Mammadova J; Aydin HM
+Authors Full Name
+ Bitkin, Eda Celebi; Kara, Cengiz; Yilmaz, Gulay Can; Mammadova, Jamala; Aydin, Hasan Murat.
+Institution
+ Bitkin, Eda Celebi. Department of Pediatrics, Van Yuzuncu Yil University, Faculty of Medicine, Division of Pediatric Endocrinology, Van, Turkey.
+ Kara, Cengiz. Department of Pediatrics, Istinye University, Faculty of Medicine, Division of Pediatric Endocrinology, Istanbul, Turkey.
+ Yilmaz, Gulay Can. Department of Pediatrics, Mugla Sitki Kocman University, Faculty of Medicine, Division of Pediatric Endocrinology, Mugla, Turkey.
+ Mammadova, Jamala. Department of Pediatrics, Istinye University, Faculty of Medicine, Division of Pediatric Endocrinology, Istanbul, Turkey.
+ Aydin, Hasan Murat. Department of Pediatrics, Ondokuz Mayis University, Faculty of Medicine, Division of Pediatric Endocrinology, Samsun, Turkey.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/me [Metabolism]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ Child
+ Child, Preschool
+ *Diabetes Mellitus, Type 1/co [Complications]
+ Dyslipidemias/et [Etiology]
+ Dyslipidemias/me [Metabolism]
+ *Dyslipidemias/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Hypertension/et [Etiology]
+ Hypertension/me [Metabolism]
+ *Hypertension/pa [Pathology]
+ Infant
+ *Insulin Resistance
+ Male
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ Retrospective Studies
+Keyword Heading
+ obesity
+ overweight
+ type 1 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Obesity is a growing problem in type 1 diabetes mellitus (T1DM) today. The aim of our study is to determine the frequency of overweight/obesity at the time of diagnosis and during follow-up in children with T1DM as well as review the conditions that may accompany.
+
+ METHODS: A total of 315 patients with T1DM were retrospectively analyzed. The patients were divided into two groups as normal weight and overweight/obese. The two groups were compared in terms of age at diagnosis, birth weight, anthropometric measurements, insulin dose used and blood pressure measurements, and insulin, c-peptide, hemoglobin A1c, triglyceride, and high-density lipoprotein levels at the time of diagnosis and follow-up.
+
+ RESULTS: The height, weight and body mass index standard deviation (BMI SD) scores, and c-peptide levels at the time of diagnosis of the overweight/obese group were higher than those with normal weight (p<0.001 and p = 0.008, respectively). The frequency of dyslipidemia and hypertension was higher in the overweight/obese group than in the normal weight group [18.2 vs. 5% (p = 0.015) and 10 vs. 1.5% (p = 0.003), respectively].
+
+ CONCLUSIONS: In our study, the fact that the overweight/obese group had higher BMI and c-peptide and lower HDL values at the time of diagnosis can be evaluated as indicators that insulin resistance syndrome can accompany T1DM from the beginning (double diabetes). When determining the treatment and follow-up strategies of patients with T1DM, considering the risk of obesity and taking the necessary precautions is very important in terms of morbidity. Copyright © 2021 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1515%2fjpem-2021-0268
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bitkin&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Evaluation+of+children+with+type+1+diabetes+mellitus+in+terms+of+overweight%2Fobesity+in+tertiary+care+hospital.&volume=34&issue=8&spage=995&epage=1000&date=2021&doi=10.1515%2Fjpem-2021-0268&pmid=34162026&sid=OVID:medline
+
+<814>
+Unique Identifier
+ 34162024
+Title
+ Metabolic syndrome and cardiorespiratory fitness in children and adolescents: the role of obesity as a mediator.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 34(8):1031-1039, 2021 Aug 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gonzalez-Galvez N; Ribeiro J; Mota J
+Author NameID
+ Gonzalez-Galvez, Noelia; ORCID: https://orcid.org/0000-0002-7291-3306
+ Ribeiro, Jose; ORCID: https://orcid.org/0000-0001-6628-4606
+Authors Full Name
+ Gonzalez-Galvez, Noelia; Ribeiro, Jose; Mota, Jorge.
+Institution
+ Gonzalez-Galvez, Noelia. Sports Injury Prevention Research Group, Faculty of Sports, Universidad Catolica de Murcia, Murcia, Spain.
+ Ribeiro, Jose. CIAFEL-Faculdade de Desporto, Universidade do Porto, Porto, Portugal.
+ Mota, Jorge. CIAFEL-Faculdade de Desporto, Universidade do Porto, Porto, Portugal.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ *Cardiorespiratory Fitness
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/pa [Pathology]
+ Child
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ *Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pa [Pathology]
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Portugal/ep [Epidemiology]
+ Prognosis
+ Risk Factors
+ *Waist Circumference
+Keyword Heading
+ cardiometabolic
+ disease
+ health behaviours
+ mediation analysis
+ prevalence
+ school
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To analyse the prevalence and association between metabolic syndrome (MetS), clustered cardiometabolic risk (CCMR), obesity (body mass index [BMI], fat mass [FM] and waist circumference [WC]), and cardiorespiratory fitness (CRF); and to assess whether obesity (BMI, FM, and WC) acts as a mediator between CRF and MetS or CCMR.
+
+ METHODS: This cross-sectional study included a subsample of the AFINA-te Study (n = 209; 11.51 +/- 0.72 years old). BMI, FM, and WC were assessed. The Course-Navette test was used to assess CRF. MetS was calculated following the International Diabetes Federation (IDF) definitions, and assessed using WC, triglycerides (TGs), high density lipoprotein (HD), fasting glucose (FG), and systolic and diastolic blood pressures (SBP/DBP). CCMR was calculated based on the sex and age-specific z score.
+
+ RESULTS: The prevalence of overweightness, obesity, MetS, and CCMR were 17.22, 1.44, 5.74, and 18.36%, respectively. After including BMI, FM, or WC into the model, the association between CRF and MetS was no longer significant, and the association between CRF and CCMR was only significant when it was mediated by BMI (beta = -0.006; p = 0.026). The rest of the analysis of the mediation did not show a direct effect, although a significant indirect effect with a significant value for the Sobel test was observed (all p < 0.001).
+
+ CONCLUSIONS: BMI, FM, and WC act as full mediators in the association between CRF and MetS; FM and WC act as full mediators in the association between CRF and CCMR; and BMI acts as a partial mediator. The use of FM or WC as obesity variables is recommended. Copyright © 2021 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1515%2fjpem-2020-0640
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gonzalez-Galvez&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Metabolic+syndrome+and+cardiorespiratory+fitness+in+children+and+adolescents%3A+the+role+of+obesity+as+a+mediator.&volume=34&issue=8&spage=1031&epage=1039&date=2021&doi=10.1515%2Fjpem-2020-0640&pmid=34162024&sid=OVID:medline
+
+<815>
+Unique Identifier
+ 34158241
+Title
+ Associations between serum amino acids and incident type 2 diabetes in Chinese rural adults.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(8):2416-2425, 2021 07 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen Y; Wang N; Dong X; Zhu J; Chen Y; Jiang Q; Fu C
+Authors Full Name
+ Chen, Yun; Wang, Na; Dong, Xiaolian; Zhu, Jianfu; Chen, Yue; Jiang, Qingwu; Fu, Chaowei.
+Institution
+ Chen, Yun. School of Public Health, Key Laboratory of Public Health Safety, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
+ Wang, Na. School of Public Health, Key Laboratory of Public Health Safety, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
+ Dong, Xiaolian. Deqing County Center for Disease Control and Prevention, Deqing, 313299, China.
+ Zhu, Jianfu. Deqing County Center for Disease Control and Prevention, Deqing, 313299, China.
+ Chen, Yue. School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1G 5Z3, Canada.
+ Jiang, Qingwu. School of Public Health, Key Laboratory of Public Health Safety, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
+ Fu, Chaowei. School of Public Health, Key Laboratory of Public Health Safety, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China. Electronic address: fcw@fudan.edu.cn.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ China/ep [Epidemiology]
+ Comorbidity
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ Humans
+ Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ Incidence
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Proline/bl [Blood]
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ *Rural Health
+Keyword Heading
+ Amino acids
+ Cohort study
+ Rural population
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Some amino acids (AAs) may be associated with type 2 diabetes (T2DM). This study aimed to determine the associations of individual AAs with the development of T2DM in rural Chinese adults.
+
+ METHODS AND RESULTS: A cohort study of 1199 individuals aged 18 years or older was conducted from 2006 to 2008 in a rural community of Deqing, China, a repeated survey was done in 2015 and data linkage with the electronic health records system was performed each year for identifying new T2DM cases. A high-performance liquid chromatography approach was used to measure the baseline serum concentrations of 15 AAs. Cox proportional hazards models were used to examine the associations between AAs and the risk of incident T2DM. A total of 98 new T2DM cases were identified during the follow-up of 12 years on average. Among 15 AAs, proline was associated with an increased risk of incident T2DM after adjusted for age, sex, body mass index, fasting plasma glucose, family history of T2DM, smoking status, alcohol use, and history of hypertension, the adjusted hazard ratio for 1-standard deviation increment was 1.20 (95% confidence interval: 1.00, 1.43). The association tended to be more marked in subjects younger than 60 years and overweight/obese subjects. Among participants without hypertension, proline and phenylalanine were associated with an increased risk of incident T2DM, while aspartic acid was associated with a decreased risk.
+
+ CONCLUSION: Serum proline was associated with the risk of incident T2DM in rural Chinese adults and might be a potential predictor. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9DLQ4CIU6V (Proline).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.05.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Associations+between+serum+amino+acids+and+incident+type+2+diabetes+in+Chinese+rural+adults.&volume=31&issue=8&spage=2416&epage=2425&date=2021&doi=10.1016%2Fj.numecd.2021.05.004&pmid=34158241&sid=OVID:medline
+
+<816>
+Unique Identifier
+ 34155300
+Title
+ The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats.
+Source
+ Scientific Reports. 11(1):13009, 2021 06 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Patel NS; Yanala UR; Aravind S; Reidelberger RD; Thompson JS; Carlson MA
+Authors Full Name
+ Patel, Neesha S; Yanala, Ujwal R; Aravind, Shruthishree; Reidelberger, Roger D; Thompson, Jon S; Carlson, Mark A.
+Institution
+ Patel, Neesha S. Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE, 68198-3280, USA.
+ Patel, Neesha S. Surgery Department, VA Medical Center, 4101 Woolworth Avenue, Omaha, NE, 68105, USA.
+ Yanala, Ujwal R. Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE, 68198-3280, USA.
+ Yanala, Ujwal R. Surgery Department, VA Medical Center, 4101 Woolworth Avenue, Omaha, NE, 68105, USA.
+ Aravind, Shruthishree. Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE, 68198-3280, USA.
+ Aravind, Shruthishree. Surgery Department, VA Medical Center, 4101 Woolworth Avenue, Omaha, NE, 68105, USA.
+ Reidelberger, Roger D. Surgery Department, VA Medical Center, 4101 Woolworth Avenue, Omaha, NE, 68105, USA.
+ Reidelberger, Roger D. Department of Biomedical Sciences, Creighton University, Omaha, NE, 68178, USA.
+ Thompson, Jon S. Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE, 68198-3280, USA.
+ Carlson, Mark A. Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE, 68198-3280, USA. macarlso@unmc.edu.
+ Carlson, Mark A. Surgery Department, VA Medical Center, 4101 Woolworth Avenue, Omaha, NE, 68105, USA. macarlso@unmc.edu.
+ Carlson, Mark A. Center for Advanced Surgical Technology, University of Nebraska Medical Center, 986245 Nebraska Medical Center, Omaha, NE, 68198-6245, USA. macarlso@unmc.edu.
+ Carlson, Mark A. Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 985805 Nebraska Medical Center, Omaha, NE, 68198-5805, USA. macarlso@unmc.edu.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Body Composition
+ Body Weights and Measures
+ Diet
+ *Intestine, Small/su [Surgery]
+ *Obesity/su [Surgery]
+ Postoperative Period
+ Preoperative Period
+ Rats
+Abstract
+ In patients with short bowel syndrome, an elevated pre-resection Body Mass Index may be protective of post-resection body composition. We hypothesized that rats with diet-induced obesity would lose less lean body mass after undergoing massive small bowel resection compared to non-obese rats. Rats (CD IGS; age = 2 mo; N = 80) were randomly assigned to either a high-fat (obese rats) or a low-fat diet (non-obese rats), and fed ad lib for six months. Each diet group then was randomized to either underwent a 75% distal small bowel resection (massive resection) or small bowel transection with re-anastomosis (sham resection). All rats then were fed ad lib with an intermediate-fat diet (25% of total calories) for two months. Body weight and quantitative magnetic resonance-determined body composition were monitored. Preoperative body weight was 884 +/- 95 versus 741 +/- 75 g, and preoperative percent body fat was 35.8 +/- 3.9 versus 24.9 +/- 4.6%; high-fat vs. low fat diet, respectively (p < 0.0001); preoperative diet type had no effect on lean mass. Regarding total body weight, massive resection produced an 18% versus 5% decrease in high-fat versus low-fat rats respectively, while sham resection produced a 2% decrease vs. a 7% increase, respectively (p < 0.0001, preoperative vs. necropsy data). Sham resection had no effect on lean mass; after massive resection, both high-fat and low-fat rats lost lean mass, but these changes were not different between the latter two rat groups. The high-fat diet and low-fat diet induced obesity and marginal obesity, respectively. The massive resection produced greater weight loss in high-fat rats compared to low-fat rats. The type of dietary preconditioning had no effect on lean mass loss after massive resection. A protective effect of pre-existing obesity on lean mass after massive intestinal resection was not demonstrated.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-92510-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Patel&issn=2045-2322&title=Scientific+Reports&atitle=The+effect+of+pre-resection+obesity+on+post-resection+body+composition+after+75%25+small+bowel+resection+in+rats.&volume=11&issue=1&spage=13009&epage=&date=2021&doi=10.1038%2Fs41598-021-92510-7&pmid=34155300&sid=OVID:medline
+
+<817>
+Unique Identifier
+ 34155068
+Title
+ Body Fat Composition Enhances the Predictive Ability of Changes in White Blood Cell Levels Associated with the Risk of Chronic Disease Development.
+Source
+ Journal of Immunology. 207(2):389-397, 2021 07 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chae J; Kim M; Lee JH; Yoo HJ
+Author NameID
+ Yoo, Hye Jin; ORCID: https://orcid.org/0000-0003-2075-0426
+Authors Full Name
+ Chae, Jisuk; Kim, Minjoo; Lee, Jong Ho; Yoo, Hye Jin.
+Institution
+ Chae, Jisuk. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Republic of Korea.
+ Kim, Minjoo. Department of Food and Nutrition, College of Life Science and Nano Technology, Hannam University, Daejeon, Republic of Korea; and.
+ Lee, Jong Ho. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Republic of Korea; jhleeb@yonsei.ac.kr hyejin_yoo@yonsei.ac.kr.
+ Lee, Jong Ho. Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Republic of Korea.
+ Yoo, Hye Jin. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Republic of Korea; jhleeb@yonsei.ac.kr hyejin_yoo@yonsei.ac.kr.
+ Yoo, Hye Jin. Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Republic of Korea.
+MeSH Subject Headings
+ Adiponectin/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Adult
+ Biomarkers/me [Metabolism]
+ *Body Composition/ph [Physiology]
+ C-Reactive Protein/me [Metabolism]
+ Chronic Disease
+ Female
+ Humans
+ Inflammation/me [Metabolism]
+ Inflammation/pp [Physiopathology]
+ Intra-Abdominal Fat/me [Metabolism]
+ *Leukocytes/me [Metabolism]
+ *Leukocytes/ph [Physiology]
+ Male
+ Middle Aged
+ Obesity
+ Young Adult
+Abstract
+ The study aimed to revalidate the influence of WBCs on chronic disease risk factors and to verify which markers are independently involved in WBC level changes in a Korean population. A total of 80 Korean subjects were divided into three groups, according to the WBC count: mild decrease in WBC, normal WBC, and mild increase in WBC. Fasting blood samples for analyzing biochemical parameters and inflammatory markers were obtained from the subjects, and their body fat composition was evaluated by dual energy x-ray absorptiometry and computed tomography. The WBC levels were related to levels of adiponectin, triglyceride, and insulin, which are associated with the risk of chronic diseases. In the mild increase in WBC group, high-sensitivity C-reactive protein (hs-CRP) and TNF-alpha levels increased, and s.c. fat area at the first lumbar vertebrae and fourth lumbar vertebrae decreased. The WBC count positively correlated with hs-CRP and TNF-alpha levels and most of the body fat composition data, evaluated by dual energy x-ray absorptiometry and computed tomography. Notably, hs-CRP and TNF-alpha levels, fat mass, and visceral-to-s.c. fat area ratio at the first lumbar vertebrae were revealed as independent predictors of WBC level change. Finally, the receiver operating characteristic curve analysis showed that the additional use of body fat composition data with the conventional inflammatory markers reliably enhanced the predictive capacity of WBC level changes. Thus, we suggest that by controlling inflammatory markers and body fat composition, WBC levels can be kept within a range that is safe from the risk of chronic diseases. Copyright © 2021 by The American Association of Immunologists, Inc.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.4049%2fjimmunol.2000790
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chae&issn=0022-1767&title=Journal+of+Immunology&atitle=Body+Fat+Composition+Enhances+the+Predictive+Ability+of+Changes+in+White+Blood+Cell+Levels+Associated+with+the+Risk+of+Chronic+Disease+Development.&volume=207&issue=2&spage=389&epage=397&date=2021&doi=10.4049%2Fjimmunol.2000790&pmid=34155068&sid=OVID:medline
+
+<818>
+Unique Identifier
+ 34153093
+Title
+ Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 106(11):e4634-e4640, 2021 10 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gao X; Li S; Dong S; Li J; Yan Y; Zhang T; Chen W
+Author NameID
+ Zhang, Tao; ORCID: https://orcid.org/0000-0003-1048-4443
+Authors Full Name
+ Gao, Xiao; Li, Shengxu; Dong, Shiqiu; Li, Jiaqi; Yan, Yinkun; Zhang, Tao; Chen, Wei.
+Institution
+ Gao, Xiao. The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China.
+ Li, Shengxu. Children's Minnesota Research Institute, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota 55404, USA.
+ Dong, Shiqiu. Department of Clinical Medicine, Heilongjiang Nursing College, Harbin, Heilongjiang 150080, China.
+ Li, Jiaqi. The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China.
+ Yan, Yinkun. Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
+ Zhang, Tao. Department of Biostatistics, School of Public Health, Shandong University, Jinan, Shandong 250012, China.
+ Chen, Wei. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Aging
+ *Biomarkers/me [Metabolism]
+ Body Mass Index
+ *Body Weight
+ *C-Reactive Protein/me [Metabolism]
+ Cohort Studies
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Inflammation/ep [Epidemiology]
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ Leukocytes/me [Metabolism]
+ Leukocytes/pa [Pathology]
+ Male
+ Middle Aged
+ Nutrition Surveys
+ *Obesity/co [Complications]
+ Prognosis
+ Telomere/ge [Genetics]
+ *Telomere/me [Metabolism]
+ United States/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ C-reactive protein
+ body mass index
+ mediation effect
+ telomere length
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging.
+
+ OBJECTIVE: This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP) on leukocyte telomere length (LTL) to determine the mediation effect of CRP on the BMI-LTL association.
+
+ METHODS: The study cohort included 5451 adults (1404 Mexican American, 3114 White, and 933 Black individuals; 53.5% male; mean age = 49.2 years) from the 1999 to 2002 National Health and Nutrition Examination Survey. General mediation models were used to examine the mediation effect of CRP on the BMI-LTL association.
+
+ RESULTS: After adjusting for age, race, sex, physical activity, alcohol use, and serum cotinine, the total effect of BMI on LTL was significant (standardized regression coefficient, beta = -.054, P < .001) without CRP included in the model. With inclusion of CRP in the model, the indirect effect of BMI on LTL through CRP was estimated at beta equal to -.023 (P < .001), and the direct effect of BMI on LTL in its absolute value decreased to beta equal to -.031 (P = .025). The mediation effect of CRP was estimated at 42.6%. The mediation model parameters did not differ significantly between race and sex groups.
+
+ CONCLUSION: These results suggest that the inverse BMI-LTL association is partly mediated by obesity-induced inflammation. The significant direct effect of BMI on LTL with removal of the mediation effect through CRP indicates that obesity is associated with LTL attrition also through other noninflammatory mechanisms. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1210%2fclinem%2fdgab455
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gao&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Association+Between+Body+Weight+and+Telomere+Length+Is+Predominantly+Mediated+Through+C-Reactive+Protein.&volume=106&issue=11&spage=e4634&epage=e4640&date=2021&doi=10.1210%2Fclinem%2Fdgab455&pmid=34153093&sid=OVID:medline
+
+<819>
+Unique Identifier
+ 34137355
+Title
+ Insulin resistance and potential modulators of ovarian reserve in young reproductive-aged women with obesity and type 1 diabetes.
+Source
+ Gynecological Endocrinology. 37(9):823-830, 2021 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Calcaterra V; Nappi RE; Pelizzo G; De Silvestri A; Albertini R; De Amici M; Tenuta E; Vinci F; Mameli C; Zuccotti G
+Author NameID
+ Calcaterra, Valeria; ORCID: https://orcid.org/0000-0002-2137-5974
+Authors Full Name
+ Calcaterra, Valeria; Nappi, Rossella E; Pelizzo, Gloria; De Silvestri, Annalisa; Albertini, Riccardo; De Amici, Mara; Tenuta, Elisavietta; Vinci, Federica; Mameli, Chiara; Zuccotti, Gianvincenzo.
+Institution
+ Calcaterra, Valeria. Pediatric and Adolescent Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
+ Calcaterra, Valeria. Department of Pediatrics, "Vittore Buzzi" Children's Hospital, Milano, Italy.
+ Nappi, Rossella E. Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
+ Nappi, Rossella E. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
+ Pelizzo, Gloria. Pediatric Surgery Department, "Vittore Buzzi" Children's Hospital, Milano, Italy.
+ Pelizzo, Gloria. Department of Biomedical and Clinical Science "L. Sacco", University of Milano, Milano, Italy.
+ De Silvestri, Annalisa. Biometry and Clinical Epidemiology, Scientific Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
+ Albertini, Riccardo. Laboratory of Clinical Chemistry, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
+ De Amici, Mara. Laboratory of Clinical Chemistry, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
+ De Amici, Mara. Pediatric Unit, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
+ Tenuta, Elisavietta. Pediatric and Adolescent Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
+ Vinci, Federica. Pediatric Unit, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
+ Mameli, Chiara. Department of Pediatrics, "Vittore Buzzi" Children's Hospital, Milano, Italy.
+ Mameli, Chiara. Department of Biomedical and Clinical Science "L. Sacco", University of Milano, Milano, Italy.
+ Zuccotti, Gianvincenzo. Department of Pediatrics, "Vittore Buzzi" Children's Hospital, Milano, Italy.
+ Zuccotti, Gianvincenzo. Department of Biomedical and Clinical Science "L. Sacco", University of Milano, Milano, Italy.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adolescent
+ Anti-Mullerian Hormone/bl [Blood]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Diabetes Mellitus, Type 1/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 1/pp [Physiopathology]
+ Female
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ Kisspeptins/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ *Ovarian Reserve/ph [Physiology]
+ Young Adult
+Keyword Heading
+ AMH
+ Young reproductive-aged women
+ adiponectin
+ kisspeptin
+ obesity
+ ovarian reserve
+ type 1 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Both obesity and diabetes play a significant role in reproductive disorders in women and insulin resistance (IR) is a confirmed trait d'union. We evaluated the relationship between IR and an established ovarian reserve biomarker such as anti-mullerian hormone (AMH) together with other potential modulators of ovarian physiology (adiponectin and kisspeptin) in young reproductive-aged group women with obesity and type 1 diabetes (T1D).
+
+ PATIENTS AND METHODS: We recruited 32 female youths: 14 of them presented with T1D (14.6 +/- 2.6 years) and 18 with obesity (15.1 +/- 2.6 years). The control group included 20 age-matched normal weight females. Each patient underwent physical examination and hormonal assessment. AMH, kisspeptin and adiponectin levels were also measured. IR was calculated as the homeostasis model assessment for insulin resistance (HOMA-IR) and the glucose disposal rate (eGDR) in patients with obesity and with T1D, respectively.
+
+ RESULTS: adiponectin and kisspeptin levels were significantly different into groups (p <= .001), whereas AMH levels were not. Adiponectin values were higher in controls compared to patients with obesity (p < .001) and T1D (p = .02). Kisspeptin levels were lower in controls compared to patients with obesity (p = .001), without reaching statistical significance when compared to T1D (p = .06). IR was associated with lower adiponectin and higher kisspeptin levels (p < .001 and p = .02, respectively), but not with AMH.
+
+ CONCLUSIONS: IR displays a relationship with adiponectin and kisspeptin in young reproductive-aged women with obesity and T1D. Interventions to correct IR in adolescents could be part of an early approach to prevent reproductive disorders and to promote factors associated with longevity in adult women.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Kisspeptins). 80497-65-0 (Anti-Mullerian Hormone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1080%2f09513590.2021.1940127
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Calcaterra&issn=0951-3590&title=Gynecological+Endocrinology&atitle=Insulin+resistance+and+potential+modulators+of+ovarian+reserve+in+young+reproductive-aged+women+with+obesity+and+type+1+diabetes.&volume=37&issue=9&spage=823&epage=830&date=2021&doi=10.1080%2F09513590.2021.1940127&pmid=34137355&sid=OVID:medline
+
+<820>
+Unique Identifier
+ 34136580
+Title
+ Association of Body Fat Percentage with Time in Range Generated by Continuous Glucose Monitoring during Continuous Subcutaneous Insulin Infusion Therapy in Type 2 Diabetes.
+Source
+ Journal of Diabetes Research. 2021:5551216, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ruan Y; Zhong J; Chen R; Zhang Z; Liu D; Sun J; Chen H
+Author NameID
+ Sun, Jia; ORCID: https://orcid.org/0000-0001-9617-5865
+ Chen, Hong; ORCID: https://orcid.org/0000-0002-6317-9955
+Authors Full Name
+ Ruan, Yuting; Zhong, Jiana; Chen, Rongping; Zhang, Zhen; Liu, Dixing; Sun, Jia; Chen, Hong.
+Institution
+ Ruan, Yuting. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 Guangdong, China.
+ Zhong, Jiana. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 Guangdong, China.
+ Chen, Rongping. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 Guangdong, China.
+ Zhang, Zhen. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 Guangdong, China.
+ Liu, Dixing. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 Guangdong, China.
+ Sun, Jia. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 Guangdong, China.
+ Chen, Hong. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 Guangdong, China.
+MeSH Subject Headings
+ *Adiposity
+ Aged
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose Self-Monitoring
+ Clinical Decision-Making
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Electric Impedance
+ Female
+ Glycemic Control/ae [Adverse Effects]
+ *Glycemic Control
+ Humans
+ *Hypoglycemic Agents/ad [Administration & Dosage]
+ Hypoglycemic Agents/ae [Adverse Effects]
+ Infusions, Subcutaneous
+ *Insulin/ad [Administration & Dosage]
+ Insulin/ae [Adverse Effects]
+ Insulin Infusion Systems/ae [Adverse Effects]
+ *Insulin Infusion Systems
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity/pp [Physiopathology]
+ Predictive Value of Tests
+ Time Factors
+ Treatment Outcome
+Abstract
+ BACKGROUND: Obesity is a crucial risk factor associated with type 2 diabetes mellitus (T2DM). Excessive accumulation of body fat may affect the glycemia control in T2DM. This study investigated the relationship between body fat percentage and time in range (TIR) assessed by continuous glucose monitoring (CGM) during short-term continuous subcutaneous insulin infusion (CSII) therapy in T2DM patients.
+
+ METHOD: A total of 85 T2DM patients were recruited in this cross-sectional study. All participants underwent 72 h CGM period during short-term CSII therapy. TIR was defined as the percentage of time spent within the target glucose range of 3.9-10.0 mmol/L. Body composition was measured using bioelectrical impedance analysis (BIA) and overfat was defined as an amount of body fat of at least 25% of total body mass for men or at least 30% for women. Multiple linear regression models were used to evaluate the independent association of body fat percentage with TIR after adjusting for confounding factors.
+
+ RESULTS: Compared with normal fat T2DM patients, individual with a higher body fat percentage exhibited lower levels of TIR (P = 0.004) and higher 72 h mean blood glucose (72 h MBG) (P = 0.001) during short-term CSII treatment. The prevalence of overfat assessed by body fat percentage decreased with the ascending TIR tertiles (P < 0.05). Multiple linear regression analysis indicated that body fat percentage was significantly associated with TIR independent of age, gender, diabetes duration, HbA1c, and BMI (P = 0.043).
+
+ CONCLUSIONS: Body fat percentage was significantly associated with TIR in T2DM during short-term CSII therapy. Reduction of body fat may be an important therapeutic target to improve glycemic control in high body fat T2DM patients, who may benefit less from intensive insulin treatment. Copyright © 2021 Yuting Ruan et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hypoglycemic Agents). 0 (Insulin).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f5551216
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ruan&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=Association+of+Body+Fat+Percentage+with+Time+in+Range+Generated+by+Continuous+Glucose+Monitoring+during+Continuous+Subcutaneous+Insulin+Infusion+Therapy+in+Type+2+Diabetes.&volume=2021&issue=&spage=5551216&epage=&date=2021&doi=10.1155%2F2021%2F5551216&pmid=34136580&sid=OVID:medline
+
+<821>
+Unique Identifier
+ 34135862
+Title
+ The Risk Threshold for Hemoglobin A1c Associated With Albuminuria: A Population-Based Study in China.
+Source
+ Frontiers in Endocrinology. 12:673976, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lian H; Wu H; Ning J; Lin D; Huang C; Li F; Liang Y; Qi Y; Ren M; Yan L; You L; Xu M
+Authors Full Name
+ Lian, Hong; Wu, Hongshi; Ning, Jie; Lin, Diaozhu; Huang, Chulin; Li, Feng; Liang, Ying; Qi, Yiqin; Ren, Meng; Yan, Li; You, Lili; Xu, Mingtong.
+Institution
+ Lian, Hong. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Wu, Hongshi. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Ning, Jie. Department of Metabolic Endocrinology, Shenzhen Longhua, District Central Hospital, Shenzhen, China.
+ Lin, Diaozhu. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Huang, Chulin. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Li, Feng. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Liang, Ying. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Qi, Yiqin. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Ren, Meng. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Yan, Li. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ You, Lili. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+ Xu, Mingtong. Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
+MeSH Subject Headings
+ *Albuminuria/ep [Epidemiology]
+ Albuminuria/pa [Pathology]
+ *Biomarkers/bl [Blood]
+ *Blood Glucose/an [Analysis]
+ China/ep [Epidemiology]
+ *Creatinine/bl [Blood]
+ Cross-Sectional Studies
+ *Diabetes Mellitus/pp [Physiopathology]
+ *Diabetic Nephropathies/et [Etiology]
+ Diabetic Nephropathies/pa [Pathology]
+ Female
+ Follow-Up Studies
+ *Glycated Hemoglobin/an [Analysis]
+ Humans
+ Hypertension/co [Complications]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ HbA1c
+ albumin to creatinine ratio
+ albuminuria
+ cross-sectional study
+ diabetic kidney disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Diabetic kidney disease (DKD) is a kind of common microvascular complication of diabetes. This study aims to explore the possible links between blood sugar level and albuminuria, providing the exact cut point of the "risk threshold" for blood glucose with DKD.
+
+ Methods: The relationship between blood glucose and albuminuria was modeled using linear and logistic regression in the REACTION study cohorts (N= 8932). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression model. Two-slope linear regression was used to simulate associations between blood glucose and ACR.
+
+ Results: We found that the increase in ACR was accompanied by increased HbA1c, with a turning point at 5.5%. The positive correlation remained highly significant (P<0.001) when adjusted for age, sex, marital status, education, smoking status, drinking status, BMI, waistline, SBP and DBP. In subgroup analyses including gender, obesity, hypertension, and smoking habits, the relationship was significant and stable.
+
+ Conclusions: We determined a risk threshold for HbA1c associated with albuminuria in a Chinese population over the age of 40. HbA1c >= 5.5% was positively and independently associated with ACR. These results suggest the necessity of early blood glucose control and renal function screening for DKD in at-risk populations. Copyright © 2021 Lian, Wu, Ning, Lin, Huang, Li, Liang, Qi, Ren, Yan, You and Xu.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.673976
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lian&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=The+Risk+Threshold+for+Hemoglobin+A1c+Associated+With+Albuminuria%3A+A+Population-Based+Study+in+China.&volume=12&issue=&spage=673976&epage=&date=2021&doi=10.3389%2Ffendo.2021.673976&pmid=34135862&sid=OVID:medline
+
+<822>
+Unique Identifier
+ 34132976
+Title
+ Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome.
+Source
+ Journal of Endocrinological Investigation. 44(12):2831-2843, 2021 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mirr M; Skrypnik D; Bogdanski P; Owecki M
+Author NameID
+ Mirr, M; ORCID: http://orcid.org/0000-0001-8094-2070
+ Skrypnik, D; ORCID: http://orcid.org/0000-0001-5643-6899
+ Owecki, M; ORCID: http://orcid.org/0000-0002-9060-0274
+Authors Full Name
+ Mirr, M; Skrypnik, D; Bogdanski, P; Owecki, M.
+Institution
+ Mirr, M. Department of Public Health, Poznan University of Medical Sciences, Rokietnicka St. 4, 60-806, Poznan, Poland. malgorzata.tapolska@gmail.com.
+ Skrypnik, D. Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego St. 82/84, 60-569, Poznan, Poland.
+ Bogdanski, P. Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego St. 82/84, 60-569, Poznan, Poland.
+ Owecki, M. Department of Public Health, Poznan University of Medical Sciences, Rokietnicka St. 4, 60-806, Poznan, Poland.
+MeSH Subject Headings
+ *Anthropometry/mt [Methods]
+ Area Under Curve
+ *Biomarkers/an [Analysis]
+ *Blood Pressure Determination/mt [Methods]
+ Body Mass Index
+ Cholesterol, HDL/an [Analysis]
+ Cholesterol, HDL/bl [Blood]
+ Female
+ Humans
+ *Insulin Resistance
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/pp [Physiopathology]
+ *Metabolic Syndrome
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ *Obesity
+ ROC Curve
+ Reproducibility of Results
+ Triglycerides/an [Analysis]
+ Triglycerides/bl [Blood]
+Keyword Heading
+ Insulin resistance
+ Metabolic syndrome
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Obesity and insulin resistance are considered cardinal to the pathophysiology of metabolic syndrome. Several simple indexes of insulin resistance calculated from biochemical or anthropometric variables have been proposed. The study aimed to assess the diagnostic accuracy of indirect insulin resistance indicators in detecting metabolic syndrome in non-diabetic patients, including TG/HDLc, METS-IR, TyG, TyG-BMI, TyG-WC, TyG-WHtR, and new indicators TyG-NC (TyG-neck circumference) and TyG-NHtR (Tyg-neck circumference to height ratio).
+
+ METHODS: The diagnostic accuracy of eight insulin resistance indexes was assessed using the receiver operating characteristic curves (ROC curves) in 665 adult non-diabetic patients. Then, the analysis was performed after the division into groups with proper body mass index, overweight and obese.
+
+ RESULTS: All indexes achieved significant diagnostic accuracy, with the highest AUC (area under the curve) for TyG (0.888) and Tg/HDLc (0.874). The highest diagnostic performance in group with the proper body mass index was shown for TyG (0.909) and TyG-BMI (0.879). The highest accuracy in the group of overweight individuals was presented by TyG (0.884) and TG/HDLc (0.855). TG/HDLc and TyG showed the highest AUC (0.880 and 0.877, respectively) in the group with obesity. Both TyG-NC and TyG-NHtR reached significant areas under the curve, which makes them useful diagnostic tests in metabolic syndrome.
+
+ CONCLUSIONS: Indirect indices of insulin resistance, including proposed TyG-NC and TyG-NHtR, show an essential diagnostic value in diagnosing metabolic syndrome. TyG and TG/HDLc seem to be the most useful in the Caucasian population. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs40618-021-01608-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mirr&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Newly+proposed+insulin+resistance+indexes+called+TyG-NC+and+TyG-NHtR+show+efficacy+in+diagnosing+the+metabolic+syndrome.&volume=44&issue=12&spage=2831&epage=2843&date=2021&doi=10.1007%2Fs40618-021-01608-2&pmid=34132976&sid=OVID:medline
+
+<823>
+Unique Identifier
+ 34131888
+Title
+ Serum fatty acid binding protein 5 (FABP5) as a potential biomarker of inflammation in psoriasis.
+Source
+ Molecular Biology Reports. 48(5):4421-4429, 2021 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kozlowska D; Mysliwiec H; Harasim-Symbor E; Milewska AJ; Chabowski A; Flisiak I
+Author NameID
+ Kozlowska, Dorota; ORCID: http://orcid.org/0000-0002-1189-0999
+Authors Full Name
+ Kozlowska, Dorota; Mysliwiec, Hanna; Harasim-Symbor, Ewa; Milewska, Anna Justyna; Chabowski, Adrian; Flisiak, Iwona.
+Institution
+ Kozlowska, Dorota. Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia str. 14, 15-540, Bialystok, Poland. dorota.kozlowska@umb.edu.pl.
+ Mysliwiec, Hanna. Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia str. 14, 15-540, Bialystok, Poland.
+ Harasim-Symbor, Ewa. Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
+ Milewska, Anna Justyna. Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland.
+ Chabowski, Adrian. Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
+ Flisiak, Iwona. Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia str. 14, 15-540, Bialystok, Poland.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ *Fatty Acid-Binding Proteins/bl [Blood]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/co [Complications]
+ Inflammation/rt [Radiotherapy]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ *Psoriasis/bl [Blood]
+ *Psoriasis/co [Complications]
+ Psoriasis/rt [Radiotherapy]
+ *Severity of Illness Index
+ Treatment Outcome
+ Ultraviolet Therapy/mt [Methods]
+ Young Adult
+Keyword Heading
+ Epidermal fatty acid binding protein
+ Fatty acid binding protein 5
+ Lipid disturbances
+ Metabolic syndrome
+ Narrowband-ultraviolet B
+ Psoriasis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Fatty acid binding protein 5 (FABP5) is elevated in psoriatic keratinocytes and could be involved in systemic metabolic disturbances in psoriasis. The aim of the study was to evaluate serum FABP5 in obese and non-obese psoriatic patients, to assess the relationship between FABP5 and the duration, severity of the disease, inflammatory and metabolic markers and influence of treatment with narrowband-ultraviolet B (NB-UVB). Seventy-four patients (30 treated with NB-UVB) with psoriasis were enrolled in the study. The serum concentrations of FABP5 were measured using Human FABP5 Enzyme-Linked Immunosorbent Assay kit. Serum fatty acids were measured by gas-liquid chromatography. Serum FABP5 levels in psoriatic patients were higher versus control group (P < 0.001). FABP5 in patients with PASI > 20 was higher compared to the mild group (PASI < 10) (P < 0.001) and serum FABP5 correlated positively with PASI score (r = 0.41, P < 0.001). There was also positive correlation between FABP5 and basic inflammation indices. Decrease of PASI after NB-UVB treatment (P < 0.001) was observed and accompanied by decrease of the serum FABP5 (P = 0.007). FABP5 is a potential marker of psoriasis, its severity and clinical outcome after therapy with NB-UVB. FABP5 may reflect metabolic disturbances in psoriatic patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FABP5 protein, human). 0 (Fatty Acid-Binding Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs11033-021-06461-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kozlowska&issn=0301-4851&title=Molecular+Biology+Reports&atitle=Serum+fatty+acid+binding+protein+5+%28FABP5%29+as+a+potential+biomarker+of+inflammation+in+psoriasis.&volume=48&issue=5&spage=4421&epage=4429&date=2021&doi=10.1007%2Fs11033-021-06461-3&pmid=34131888&sid=OVID:medline
+
+<824>
+Unique Identifier
+ 34122339
+Title
+ Adverse Effects of Selected Markers on the Metabolic and Endocrine Profiles of Obese Women With and Without PCOS.
+Source
+ Frontiers in Endocrinology. 12:665446, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Daghestani MH; Daghestani MH; Warsy A; El-Ansary A; Omair MA; Omair MA; Hassen LM; Alhumaidhi EM; Al Qahtani B; Harrath AH
+Authors Full Name
+ Daghestani, Mazin H; Daghestani, Maha H; Warsy, Arjumand; El-Ansary, Afaf; Omair, Mohammed A; Omair, Maha A; Hassen, Lena M; Alhumaidhi, Eman Mh; Al Qahtani, Bashaer; Harrath, Abdel Halim.
+Institution
+ Daghestani, Mazin H. Department of Obstetrics & Gynaecology, Medical College, Umm-Al-Qura University, Makkah, Saudi Arabia.
+ Daghestani, Maha H. Zoology Department, Science College, King Saud University, Riyadh, Saudi Arabia.
+ Warsy, Arjumand. Central Laboratory, Center for Science and Medical Studies for Girls, King Saud University, Riyadh, Saudi Arabia.
+ El-Ansary, Afaf. Central Laboratory, Center for Science and Medical Studies for Girls, King Saud University, Riyadh, Saudi Arabia.
+ Omair, Mohammed A. Rheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
+ Omair, Maha A. Department of Statistics and Operations Research, College of Sciences, King Saud University, Riyadh, Saudi Arabia.
+ Hassen, Lena M. Zoology Department, Science College, King Saud University, Riyadh, Saudi Arabia.
+ Alhumaidhi, Eman Mh. Zoology Department, Science College, King Saud University, Riyadh, Saudi Arabia.
+ Al Qahtani, Bashaer. Zoology Department, Science College, King Saud University, Riyadh, Saudi Arabia.
+ Harrath, Abdel Halim. Zoology Department, Science College, King Saud University, Riyadh, Saudi Arabia.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ Follicle Stimulating Hormone/bl [Blood]
+ Follow-Up Studies
+ Ghrelin/bl [Blood]
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Luteinizing Hormone/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Polycystic Ovary Syndrome/bl [Blood]
+ *Polycystic Ovary Syndrome/ep [Epidemiology]
+ Polycystic Ovary Syndrome/pa [Pathology]
+ Prognosis
+ Prospective Studies
+ Sex Hormone-Binding Globulin/me [Metabolism]
+ Testosterone/bl [Blood]
+ Young Adult
+Keyword Heading
+ estradiol
+ kisspeptin
+ obesity
+ polycystic ovary syndrome
+ vascular endothelial growth factor
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The aim of the present study, is to investigate the influence of obesity, with and without polycystic ovarian syndrome (PCOS), on the levels of kisspeptin, vitamin D (Vit D), and vascular endothelial growth factor (VEGF) and to explore the relationship between these parameters and endocrine and metabolic variables. The study group included 126 obese Saudi females. Of these 63 were suffering from PCOS while the rest were normo-ovulatory obese women (non-PCOS obese). In the obese PCOS, VEGF was almost four times as high as in the non-PCOS obese, while kisspeptin and Vit D did not differ. A highly significant elevation was recorded in the waist/hip (WHR), cholesterol, LDL-C, fasting glucose, LH, LH/FSH ratio, estradiol (E2), and testosterone, while hip circumference, leptin, progesterone, and sex hormone binding globulin (SHBG) were lower in the obese PCOS subjects. BMI, HDL-C, ghrelin, insulin, and FSH levels did not differ significantly between the two groups. The obese PCOS had the same level of insulin resistance as the non-PCOS group, as judged by QUICK Index. Correlation studies showed a significant negative correlation between kisspeptin and glucose and LH levels, and a positive correlation with LH/FSH ratio in obese PCOS while in the non-PCOS obese, the kisspeptin correlated positively with glucose, and there was no correlation with LH or LH/FSH. VEGF negatively correlated with FSH and positively with LH/FSH ratio in the non-PCOS obese but this was lost in the obese PCOS. PCOS had no effect on the correlation between Vit D and all studied parameters. Multiple regression analysis showed triglyceride as predictor variable for kisspeptin as a dependent variable, while, leptin is a predictor variable for VEGF as a dependent variable. ROC studies showed the highest sensitivity and specificity for VEGF (AOC=1.00), followed by LH/FSH ratio (AOC=0.979). In conclusion, our study shows that PCOS results in significant elevation of VEGF in obese females, while kisspeptin and Vit D levels are not affected. It also leads to elevation in several of the lipid and hormonal abnormalities in the obese females. In addition, PCOS influences relationship between Kisspeptin and VEGF and some parameters such as glucose, LH or FSH and LH/FSH ratio in obese females, but does not affect Vit D relationship with other parameter. Copyright © 2021 Daghestani, Daghestani, Warsy, El-Ansary, Omair, Omair, Hassen, Alhumaidhi, Al Qahtani and Harrath.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (GHRL protein, human). 0 (Ghrelin). 0 (Insulin). 0 (SHBG protein, human). 0 (Sex Hormone-Binding Globulin). 3XMK78S47O (Testosterone). 9002-67-9 (Luteinizing Hormone). 9002-68-0 (Follicle Stimulating Hormone).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.665446
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Daghestani&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Adverse+Effects+of+Selected+Markers+on+the+Metabolic+and+Endocrine+Profiles+of+Obese+Women+With+and+Without+PCOS.&volume=12&issue=&spage=665446&epage=&date=2021&doi=10.3389%2Ffendo.2021.665446&pmid=34122339&sid=OVID:medline
+
+<825>
+Unique Identifier
+ 34119536
+Title
+ Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity.
+Source
+ Metabolism: Clinical & Experimental. 121:154815, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Clemente-Olivo MP; Habibe JJ; Vos M; Ottenhoff R; Jongejan A; Herrema H; Zelcer N; Kooijman S; Rensen PCN; van Raalte DH; Nieuwdorp M; Eringa EC; de Vries CJ
+Authors Full Name
+ Clemente-Olivo, Maria P; Habibe, Jayron J; Vos, Mariska; Ottenhoff, Roelof; Jongejan, Aldo; Herrema, Hilde; Zelcer, Noam; Kooijman, Sander; Rensen, Patrick C N; van Raalte, Daniel H; Nieuwdorp, Max; Eringa, Etto C; de Vries, Carlie J.
+Institution
+ Clemente-Olivo, Maria P. Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences, and Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
+ Habibe, Jayron J. Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences, and Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands; Department of Physiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, location VUmc, Amsterdam, the Netherlands.
+ Vos, Mariska. Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences, and Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
+ Ottenhoff, Roelof. Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences, and Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
+ Jongejan, Aldo. Department of Bioinformatics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
+ Herrema, Hilde. Department of Experimental Vascular Medicine, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, the Netherlands.
+ Zelcer, Noam. Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences, and Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
+ Kooijman, Sander. Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
+ Rensen, Patrick C N. Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
+ van Raalte, Daniel H. Department of Internal Medicine, Diabetes Center, Amsterdam UMC, Amsterdam Cardiovascular Sciences Amsterdam, the Netherlands.
+ Nieuwdorp, Max. Department of Experimental Vascular Medicine, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, the Netherlands.
+ Eringa, Etto C. Department of Physiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, location VUmc, Amsterdam, the Netherlands.
+ de Vries, Carlie J. Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences, and Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands. Electronic address: c.j.devries@amsterdamumc.nl.
+MeSH Subject Headings
+ Adipogenesis/ge [Genetics]
+ Adipose Tissue, White/me [Metabolism]
+ Adult
+ Aged
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat
+ Female
+ Genetic Predisposition to Disease
+ Humans
+ *LIM-Homeodomain Proteins/ge [Genetics]
+ LIM-Homeodomain Proteins/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Knockout
+ Middle Aged
+ *Muscle Proteins/ge [Genetics]
+ Muscle Proteins/me [Metabolism]
+ Obesity/di [Diagnosis]
+ *Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ *Transcription Factors/ge [Genetics]
+ Transcription Factors/me [Metabolism]
+ Weight Gain/ge [Genetics]
+Keyword Heading
+ Browning of WAT
+ Diet-induced obese mice
+ Energy expenditure
+ Energy metabolism
+ Four-and-a-half LIM domain protein 2 (FHL2)
+ Glucose uptake
+ Lipid uptake
+ White adipose tissue (WAT)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Four-and-a-Half-LIM-domain-protein 2 (FHL2) modulates multiple signal transduction pathways but has not been implicated in obesity or energy metabolism. In humans, methylation and expression of the FHL2 gene increases with age, and high FHL2 expression is associated with increased body weight in humans and mice. This led us to hypothesize that FHL2 is a determinant of diet-induced obesity.
+
+ METHODS: FHL2-deficient (FHL2-/-) and wild type male mice were fed a high-fat diet. Metabolic phenotyping of these mice, as well as transcriptional analysis of key metabolic tissues was performed. Correlation of the expression of FHL2 and relevant genes was assessed in datasets from white adipose tissue of individuals with and without obesity.
+
+ RESULTS: FHL2 Deficiency protects mice from high-fat diet-induced weight gain, whereas glucose handling is normal. We observed enhanced energy expenditure, which may be explained by a combination of changes in multiple tissues; mild activation of brown adipose tissue with increased fatty acid uptake, increased cardiac glucose uptake and browning of white adipose tissue. Corroborating our findings in mice, expression of FHL2 in human white adipose tissue positively correlates with obesity and negatively with expression of browning-associated genes.
+
+ CONCLUSION: Our results position FHL2 as a novel regulator of obesity and energy expenditure in mice and human. Given that FHL2 expression increases during aging, we now show that low FHL2 expression associates with a healthy metabolic state. Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FHL2 protein, human). 0 (Fhl2 protein, mouse). 0 (LIM-Homeodomain Proteins). 0 (Muscle Proteins). 0 (Transcription Factors).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.metabol.2021.154815
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Clemente-Olivo&issn=0026-0495&title=Metabolism%3A+Clinical+%26+Experimental&atitle=Four-and-a-half+LIM+domain+protein+2+%28FHL2%29+deficiency+protects+mice+from+diet-induced+obesity+and+high+FHL2+expression+marks+human+obesity.&volume=121&issue=&spage=154815&epage=&date=2021&doi=10.1016%2Fj.metabol.2021.154815&pmid=34119536&sid=OVID:medline
+
+<826>
+Unique Identifier
+ 34116892
+Title
+ Maternal gut microbiota displays minor changes in overweight and obese women with GDM.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(7):2131-2139, 2021 06 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mullins TP; Tomsett KI; Gallo LA; Callaway LK; McIntyre HD; Dekker Nitert M; Barrett HL
+Authors Full Name
+ Mullins, Thomas P; Tomsett, Kate I; Gallo, Linda A; Callaway, Leonie K; McIntyre, H David; Dekker Nitert, Marloes; Barrett, Helen L.
+Institution
+ Mullins, Thomas P. Mater Research Institute-The University of Queensland, Brisbane, Australia.
+ Tomsett, Kate I. School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia.
+ Gallo, Linda A. School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.
+ Callaway, Leonie K. Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Australia.
+ McIntyre, H David. Mater Research Institute-The University of Queensland, Brisbane, Australia; Department of Endocrinology, Mater Health, Australia.
+ Dekker Nitert, Marloes. School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia.
+ Barrett, Helen L. Mater Research Institute-The University of Queensland, Brisbane, Australia; Department of Endocrinology, Mater Health, Australia. Electronic address: helen.barrett@mater.uq.edu.au.
+MeSH Subject Headings
+ Adult
+ Bacteria/ge [Genetics]
+ *Bacteria/gd [Growth & Development]
+ Biomarkers/bl [Blood]
+ Diabetes, Gestational/bl [Blood]
+ Diabetes, Gestational/di [Diagnosis]
+ *Diabetes, Gestational/mi [Microbiology]
+ *Dysbiosis
+ Feces/mi [Microbiology]
+ Female
+ *Gastrointestinal Microbiome
+ *Gastrointestinal Tract/mi [Microbiology]
+ Gestational Age
+ Humans
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/mi [Microbiology]
+ Pregnancy
+ Randomized Controlled Trials as Topic
+ Ribotyping
+Keyword Heading
+ GDM
+ Metabolism
+ Microbiota
+ Obesity
+ Pregnancy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Previous literature have shown a diversity of findings regarding the relationship between the maternal gut microbiota and gestational diabetes mellitus (GDM). We investigated the gut microbiota of overweight and obese women with gestational diabetes mellitus (GDM) against matched euglycaemic women at 16 and 28-weeks' gestation.
+
+ METHODS AND RESULTS: This study included women from the SPRING (Study of PRobiotics IN Gestational diabetes) cohort. Overweight and obese women with no impaired glucose tolerance or impaired fasted glucose were enrolled prior to gestational age <16 weeks. Participants with a diagnosis of GDM (n = 29) were matched with euglycaemic (n = 29) women for body mass index, probiotic or placebo intervention, maternal age, parity and ethnicity. Anthropometric, clinical and fecal microbiota (16S rRNA amplicon-based sequencing of V6-V8 region) data was assessed at 16 and 28-weeks' gestation. The relative abundances of key bacterial genera were not significantly altered between euglycaemic women and women with GDM. Occurrence of bacterial taxa was similar between groups at both timepoints. GDM was associated with decreased Shannon diversity (p = 0.02) without differentiated clustering measured by beta diversity at 28-weeks' gestation.
+
+ CONCLUSIONS: Overweight and obese women with GDM demonstrate minor variation in the gut microbiota at 16 and 28-weeks' gestation compared with matched euglycaemic women. This study expands on previous literature concluding the microbiota does not likely have a disease-specific characterisation in GDM. Copyright © 2021. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.03.029
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mullins&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Maternal+gut+microbiota+displays+minor+changes+in+overweight+and+obese+women+with+GDM.&volume=31&issue=7&spage=2131&epage=2139&date=2021&doi=10.1016%2Fj.numecd.2021.03.029&pmid=34116892&sid=OVID:medline
+
+<827>
+Unique Identifier
+ 34112580
+Title
+ Time of eating and cardiorespiratory fitness in patients with heart failure with preserved ejection fraction and obesity.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(8):2471-2473, 2021 07 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Billingsley HE; Dixon DL; Canada JM; Kirkman DL; Rotelli B; Kadariya D; Bohmke N; Markley R; Van Tassell BW; Celi FS; Abbate A; Carbone S
+Authors Full Name
+ Billingsley, Hayley E; Dixon, Dave L; Canada, Justin M; Kirkman, Danielle L; Rotelli, Brando; Kadariya, Dinesh; Bohmke, Natalie; Markley, Roshanak; Van Tassell, Benjamin W; Celi, Francesco S; Abbate, Antonio; Carbone, Salvatore.
+Institution
+ Billingsley, Hayley E. Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, VA, USA; VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
+ Dixon, Dave L. VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA; Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA.
+ Canada, Justin M. VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
+ Kirkman, Danielle L. Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, VA, USA.
+ Rotelli, Brando. VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
+ Kadariya, Dinesh. VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
+ Bohmke, Natalie. Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, VA, USA.
+ Markley, Roshanak. VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
+ Van Tassell, Benjamin W. VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA; Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA.
+ Celi, Francesco S. Division of Endocrinology Diabetes and Metabolism, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
+ Abbate, Antonio. VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
+ Carbone, Salvatore. Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, VA, USA; VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: scarbone@vcu.edu.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Cardiorespiratory Fitness
+ Cross-Sectional Studies
+ Energy Intake
+ Exercise Tolerance
+ *Feeding Behavior
+ Female
+ Heart Failure/co [Complications]
+ Heart Failure/di [Diagnosis]
+ *Heart Failure/pp [Physiopathology]
+ Humans
+ Male
+ *Meals
+ Middle Aged
+ Natriuretic Peptide, Brain/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity/pp [Physiopathology]
+ Oxygen Consumption
+ Peptide Fragments/bl [Blood]
+ Prospective Studies
+ *Stroke Volume
+ Time Factors
+ *Ventricular Function, Left
+Keyword Heading
+ Cardiorespiratory fitness
+ Heart failure with preserved ejection fraction
+ Time of eating
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Our objective was to examine the impact of caloric intake before or after the mean time of evening meal on cardiorespiratory fitness (CRF) in patients with heart failure with preserved ejection fraction (HFpEF) and obesity.
+
+ METHODS AND RESULTS: Twelve patients with HFpEF and obesity completed a cardiorespiratory exercise test to measure CRF, defined as peak oxygen consumption (VO2). Three five-pass 24-h dietary recalls were performed for each participant and mean evening meal time was determined for each participant individually as well as the group. Participants were divided into those who ate before (Group I) and after (Group II) the mean time of evening meal, 7:25 PM. Peak VO2 and exercise time were significantly greater in Group II compared to Group I, moreover, delaying time of evening meal was associated with greater peak VO2.
+
+ CONCLUSION: Caloric intake after the mean time of evening meal was associated with better CRF in patients with HFpEF and concomitant obesity. Later nutrient intake may help prevent fasting related stress associated with cardiac metabolic disturbances present in HFpEF. Based on these findings, prospective trials aimed at examining the effects of later evening meal times in patients with HFpEF and obesity are warranted. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.04.018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Billingsley&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Time+of+eating+and+cardiorespiratory+fitness+in+patients+with+heart+failure+with+preserved+ejection+fraction+and+obesity.&volume=31&issue=8&spage=2471&epage=2473&date=2021&doi=10.1016%2Fj.numecd.2021.04.018&pmid=34112580&sid=OVID:medline
+
+<828>
+Unique Identifier
+ 34109768
+Title
+ Obesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients with COVID-19 in the US.
+Source
+ Obesity. 29(10):1719-1730, 2021 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Friedman AN; Guirguis J; Kapoor R; Gupta S; Leaf DE; Timsina LR
+Author NameID
+ Friedman, Allon N; ORCID: https://orcid.org/0000-0003-2515-1748
+Corporate Author
+ STOP-COVID Investigators
+Authors Full Name
+ Friedman, Allon N; Guirguis, John; Kapoor, Rajat; Gupta, Shruti; Leaf, David E; Timsina, Lava R.
+Institution
+ Friedman, Allon N. Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
+ Guirguis, John. Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
+ Kapoor, Rajat. Division of Pulmonary and Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
+ Gupta, Shruti. Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
+ Leaf, David E. Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
+ Timsina, Lava R. Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Acute Kidney Injury/ep [Epidemiology]
+ Acute Kidney Injury/vi [Virology]
+ Aged
+ Biomarkers/me [Metabolism]
+ *COVID-19/ep [Epidemiology]
+ COVID-19/vi [Virology]
+ Critical Illness/ep [Epidemiology]
+ Female
+ Humans
+ *Inflammation/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ Respiratory Distress Syndrome/ep [Epidemiology]
+ Respiratory Distress Syndrome/vi [Virology]
+ SARS-CoV-2/py [Pathogenicity]
+ *Thrombosis/ep [Epidemiology]
+ United States/ep [Epidemiology]
+Abstract
+ OBJECTIVE: This study aimed to determine whether obesity is independently associated with major adverse clinical outcomes and inflammatory and thrombotic markers in critically ill patients with COVID-19.
+
+ METHODS: The primary outcome was in-hospital mortality in adults with COVID-19 admitted to intensive care units across the US. Secondary outcomes were acute respiratory distress syndrome (ARDS), acute kidney injury requiring renal replacement therapy (AKI-RRT), thrombotic events, and seven blood markers of inflammation and thrombosis. Unadjusted and multivariable-adjusted models were used.
+
+ RESULTS: Among the 4,908 study patients, mean (SD) age was 60.9 (14.7) years, 3,095 (62.8%) were male, and 2,552 (52.0%) had obesity. In multivariable models, BMI was not associated with mortality. Higher BMI beginning at 25 kg/m2 was associated with a greater risk of ARDS and AKI-RRT but not thrombosis. There was no clinically significant association between BMI and inflammatory or thrombotic markers.
+
+ CONCLUSIONS: In critically ill patients with COVID-19, higher BMI was not associated with death or thrombotic events but was associated with a greater risk of ARDS and AKI-RRT. The lack of an association between BMI and circulating biomarkers calls into question the paradigm that obesity contributes to poor outcomes in critically ill patients with COVID-19 by upregulating systemic inflammatory and prothrombotic pathways. Copyright © 2021 The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1002%2foby.23245
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Friedman&issn=1930-7381&title=Obesity&atitle=Obesity%2C+inflammatory+and+thrombotic+markers%2C+and+major+clinical+outcomes+in+critically+ill+patients+with+COVID-19+in+the+US.&volume=29&issue=10&spage=1719&epage=1730&date=2021&doi=10.1002%2Foby.23245&pmid=34109768&sid=OVID:medline
+
+<829>
+Unique Identifier
+ 34108550
+Title
+ Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery.
+Source
+ Scientific Reports. 11(1):12127, 2021 06 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Villarreal-Calderon JR; Cuellar-Tamez R; Castillo EC; Luna-Ceron E; Garcia-Rivas G; Elizondo-Montemayor L
+Authors Full Name
+ Villarreal-Calderon, Jose Romeo; Cuellar-Tamez, Ricardo; Castillo, Elena C; Luna-Ceron, Eder; Garcia-Rivas, Gerardo; Elizondo-Montemayor, Leticia.
+Institution
+ Villarreal-Calderon, Jose Romeo. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, 64710, Monterrey, Mexico.
+ Villarreal-Calderon, Jose Romeo. Tecnologico de Monterrey, Centro de Investigacion en Obesidad y Nutricion Clinica, 64710, Monterrey, Mexico.
+ Villarreal-Calderon, Jose Romeo. Tecnologico de Monterrey. Cardiovascular Medicine and Metabolomics Research Group, Hospital Zambrano Hellion, TecSalud, 66278, San Pedro Garza Garcia, Mexico.
+ Cuellar-Tamez, Ricardo. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, 64710, Monterrey, Mexico.
+ Cuellar-Tamez, Ricardo. Tecnologico de Monterrey. Cardiovascular Medicine and Metabolomics Research Group, Hospital Zambrano Hellion, TecSalud, 66278, San Pedro Garza Garcia, Mexico.
+ Castillo, Elena C. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, 64710, Monterrey, Mexico.
+ Castillo, Elena C. Tecnologico de Monterrey. Cardiovascular Medicine and Metabolomics Research Group, Hospital Zambrano Hellion, TecSalud, 66278, San Pedro Garza Garcia, Mexico.
+ Luna-Ceron, Eder. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, 64710, Monterrey, Mexico.
+ Luna-Ceron, Eder. Tecnologico de Monterrey. Cardiovascular Medicine and Metabolomics Research Group, Hospital Zambrano Hellion, TecSalud, 66278, San Pedro Garza Garcia, Mexico.
+ Garcia-Rivas, Gerardo. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, 64710, Monterrey, Mexico. gdejesus@tec.mx.
+ Garcia-Rivas, Gerardo. Tecnologico de Monterrey, Centro de Investigacion Biomedica, Hospital Zambrano Hellion, TecSalud, 66278, San Pedro Garza Garcia, Mexico. gdejesus@tec.mx.
+ Garcia-Rivas, Gerardo. Tecnologico de Monterrey. Cardiovascular Medicine and Metabolomics Research Group, Hospital Zambrano Hellion, TecSalud, 66278, San Pedro Garza Garcia, Mexico. gdejesus@tec.mx.
+ Elizondo-Montemayor, Leticia. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, 64710, Monterrey, Mexico. lelizond@tec.mx.
+ Elizondo-Montemayor, Leticia. Tecnologico de Monterrey, Centro de Investigacion en Obesidad y Nutricion Clinica, 64710, Monterrey, Mexico. lelizond@tec.mx.
+ Elizondo-Montemayor, Leticia. Tecnologico de Monterrey. Cardiovascular Medicine and Metabolomics Research Group, Hospital Zambrano Hellion, TecSalud, 66278, San Pedro Garza Garcia, Mexico. lelizond@tec.mx.
+MeSH Subject Headings
+ Adult
+ *Bariatric Surgery/mt [Methods]
+ *Bariatrics/mt [Methods]
+ *Biomarkers/bl [Blood]
+ Cytokines/bl [Blood]
+ Female
+ Humans
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ *Inflammation/pc [Prevention & Control]
+ Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/su [Surgery]
+ Prospective Studies
+Abstract
+ Bariatric and metabolic surgery has shown to promote weight loss and reduce systemic inflammation. However, the sequence and timing of events regarding metabolic improvement and inflammation resolution has been rarely explored. Furthermore, data on inflammatory markers of Th17 and Th1 cell responses after bariatric surgery is scarce. We conducted a prospective study in subjects with obesity that underwent bariatric and metabolic surgery, with follow-ups at 3 and 6 months. Anthropometric and metabolic markers such as insulin levels, HOMA-IR, and lipid parameters declined significantly 3 months after surgery; while hs-CRP, TNF-alpha, IL-1beta, IL-6, and IL-8 serum concentrations decreased 6 months after the procedure. Concentrations of Th1 signature and driver cytokines, particularly IFN-gamma, IL-12, and IL-18, and of Th17 driver IL-23 also decreased significantly after 6 months. Significant positive correlations between triglyceride levels and hs-CRP, IL-1beta, and IFN-gamma concentrations, and between Apo B and IFN-gamma levels were observed 6 months after bariatric and metabolic surgery. In addition, BMI was associated with hs-CRP and TNF-alpha concentrations. Fat mass correlated with hs-CRP, TNF-alpha, and IL-12. Analysis of the temporality of metabolic and inflammatory events suggests that improvement in the metabolic status occurs before resolution of systemic inflammation and may be a requisite for the later event.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-91393-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Villarreal-Calderon&issn=2045-2322&title=Scientific+Reports&atitle=Metabolic+shift+precedes+the+resolution+of+inflammation+in+a+cohort+of+patients+undergoing+bariatric+and+metabolic+surgery.&volume=11&issue=1&spage=12127&epage=&date=2021&doi=10.1038%2Fs41598-021-91393-y&pmid=34108550&sid=OVID:medline
+
+<830>
+Unique Identifier
+ 34107965
+Title
+ High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery.
+Source
+ Cardiovascular Diabetology. 20(1):118, 2021 06 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ La Sala L; Tagliabue E; Vieira E; Pontiroli AE; Folli F
+Author NameID
+ Pontiroli, Antonio E; ORCID: https://orcid.org/0000-0002-8217-7672
+Authors Full Name
+ La Sala, Lucia; Tagliabue, Elena; Vieira, Elaine; Pontiroli, Antonio E; Folli, Franco.
+Institution
+ La Sala, Lucia. Lab. of Cardiovascular and Dysmetabolic Disease, IRCCS MultiMedica, 20138, Milan, Italy. lucia.lasala@multimedica.it.
+ Tagliabue, Elena. Value-based Healthcare Unit, IRCCS MultiMedica, Milan, Italy.
+ Vieira, Elaine. Postgraduate Program on Physical Education, Universidade Catolica de Brasilia, Taguatinga, DF, 71966-700, Brazil.
+ Pontiroli, Antonio E. Dipartimento di Scienze della Salute, Universita degli Studi di Milano, 20142, Milan, Italy. antonio.pontiroli@unimi.it.
+ Folli, Franco. Dipartimento di Scienze della Salute, Universita degli Studi di Milano, 20142, Milan, Italy.
+ Folli, Franco. Unita di Endocrinologia, Ospedale San Paolo, ASST Santi Paolo e Carlo, Milan, Italy.
+MeSH Subject Headings
+ Adult
+ *Arterial Pressure
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Female
+ *Gastroplasty
+ Humans
+ *Hypertension/bl [Blood]
+ Hypertension/di [Diagnosis]
+ Hypertension/pp [Physiopathology]
+ *Laparoscopy
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/su [Surgery]
+ *Renin/bl [Blood]
+ *Renin-Angiotensin System
+ Severity of Illness Index
+ Time Factors
+ Treatment Outcome
+ Weight Loss
+Keyword Heading
+ Aldosterone
+ Bariatric surgery
+ Diabetes
+ Ferritin
+ HOMA index
+ Hypertension
+ Laparoscopic gastric banding (LAGB)
+ Obesity
+ Renin
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Information about the renin-angiotensin-aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance.
+
+ METHODS: 239 subjects were evaluated at baseline, and 181 one year after bariatric surgery [laparoscopic gastric banding (LAGB)].
+
+ RESULTS: At baseline, renin (plasma renin activity, PRA) was increased from normal to glucose tolerance and more in diabetes, also correlating with ferritin. After LAGB, the decrease of PRA and aldosterone was significant in hypertensive, but not in normotensive subjects, and correlatied with decrease of ferritin. PRA and glucose levels were predictive of persistent hypertension 1 year after LAGB.
+
+ CONCLUSIONS: These data support the role of RAAS in the pathophysiology of glucose homeostasis, and in the regulation of blood pressure in obesity. Ferritin, as a proxy of subclinical inflammation, could be another factor contributing to the cross-talk between RAAS and glucose metabolism.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). EC 3-4-23-15 (Renin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1186%2fs12933-021-01310-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=La+Sala&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=High+plasma+renin+activity+associates+with+obesity-related+diabetes+and+arterial+hypertension%2C+and+predicts+persistent+hypertension+after+bariatric+surgery.&volume=20&issue=1&spage=118&epage=&date=2021&doi=10.1186%2Fs12933-021-01310-w&pmid=34107965&sid=OVID:medline
+
+<831>
+Unique Identifier
+ 34105575
+Title
+ Apple consumption reduces markers of postprandial inflammation following a high fat meal in overweight and obese adults: A randomized, crossover trial.
+Source
+ Food & Function. 12(14):6348-6362, 2021 Jul 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liddle DM; Lin X; Ward EM; Cox LC; Wright AJ; Robinson LE
+Authors Full Name
+ Liddle, Danyelle M; Lin, Xinjie; Ward, Emily M; Cox, Liam C; Wright, Amanda J; Robinson, Lindsay E.
+Institution
+ Liddle, Danyelle M . Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2 W1, Canada. lrobinso@uoguelph.ca.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Cross-Over Studies
+ Cytokines/bl [Blood]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Female
+ Fruit
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/dh [Diet Therapy]
+ Interleukin-6/bl [Blood]
+ Leukocytes, Mononuclear/me [Metabolism]
+ Male
+ *Malus
+ Metabolic Diseases/ep [Epidemiology]
+ Middle Aged
+ *Obesity/dh [Diet Therapy]
+ *Overweight/dh [Diet Therapy]
+ Postprandial Period
+ Risk Factors
+ Treatment Outcome
+Abstract
+ High fat meal-induced postprandial inflammation is exacerbated in overweight and obesity and may contribute to cardiovascular disease (CVD) risk. This study aimed to determine the effects of apples, rich in anti-inflammatory polyphenols, on biomarkers of postprandial inflammation in individuals with overweight and obesity. A randomized, crossover trial was conducted with n = 26 participants (17 female/9 male; mean age 45.5 +/- 3.12 years; mean BMI 34.1 +/- 1.18 kg m-2) to assess the effects of 3 whole Gala apples (~200 g) on the 2, 4 and 6 h postprandial response to a high fat meal providing 1 g fat per kg body weight. Changes in plasma biomarkers of inflammation (as the primary outcome) and endotoxin exposure, non-esterified fatty acids (NEFA) and total antioxidant capacity (TAC) were measured. Fasting (0 h) and 4 h peripheral blood mononuclear cells (PBMC) were also isolated from whole blood and stimulated with or without a physiological dose (10 ng mL-1) of lipopolysaccharide (LPS) to measure secreted cytokines. Apples modulated postprandial plasma IFN-gamma and reduced its peak concentration (-12.8%), and increased both 4 h (14.4%) and peak (10.5%) TAC (P < 0.05). In unstimulated and LPS-stimulated PBMC, apples reduced secreted IL-6 (-49.3% and -17.1%) and TNF-alpha (-43.3% and -14.7%) and increased IL-4 (93.1% and 15.8%) in both the unstimulated and LPS-stimulated conditions, as well as decreased GM-CSF (-26.0%) and IL-17 (-47.9%) in unstimulated PBMC and G-CSF (-19.8%) in LPS-stimulated PBMC (P < 0.05). These data suggest acute whole Gala apple consumption may be an effective dietary strategy to mitigate high fat meal-induced postprandial inflammation that exacerbates CVD risk in overweight and obesity. This study was registered at clinicaltrials.gov, NCT03523403, The Apple Study: Investigating the Effects of Whole Apple Consumption on Risk Factors for Chronic Metabolic Diseases in Overweight and Obese Adults.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Interleukin-6).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1039%2fd1fo00392e
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liddle&issn=2042-6496&title=Food+%26+Function&atitle=Apple+consumption+reduces+markers+of+postprandial+inflammation+following+a+high+fat+meal+in+overweight+and+obese+adults%3A+A+randomized%2C+crossover+trial.&volume=12&issue=14&spage=6348&epage=6362&date=2021&doi=10.1039%2Fd1fo00392e&pmid=34105575&sid=OVID:medline
+
+<832>
+Unique Identifier
+ 34097971
+Title
+ Intestinal GLUT5 and FAT/CD36 transporters and blood glucose are reduced by a carotenoid/MUFA-rich oil in high-fat fed mice.
+Source
+ Life Sciences. 279:119672, 2021 Aug 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Evangelista-Silva PH; Prates RP; Leite JSM; Moreno LG; Goulart-Silva F; Esteves EA
+Authors Full Name
+ Evangelista-Silva, Paulo Henrique; Prates, Rodrigo Pereira; Leite, Jaqueline Santos Moreira; Moreno, Lauane Gomes; Goulart-Silva, Francemilson; Esteves, Elizabethe Adriana.
+Institution
+ Evangelista-Silva, Paulo Henrique. Faculty of Biological and Health Sciences, Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM, Rodovia MGT 367 - Km 583. n. 5000, Alto da Jacuba, Diamantina, MG 39100-000, Brazil; Institute of Biomedical Sciences, Department of Physiology and Biophysics, Universidade de Sao Paulo - USP, Av. Prof. Dr. Lineu Prestes. 1524, Butanta, Sao Paulo, SP 05508-000, Brazil.
+ Prates, Rodrigo Pereira. Faculty of Biological and Health Sciences, Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM, Rodovia MGT 367 - Km 583. n. 5000, Alto da Jacuba, Diamantina, MG 39100-000, Brazil.
+ Leite, Jaqueline Santos Moreira. Institute of Biomedical Sciences, Department of Physiology and Biophysics, Universidade de Sao Paulo - USP, Av. Prof. Dr. Lineu Prestes. 1524, Butanta, Sao Paulo, SP 05508-000, Brazil.
+ Moreno, Lauane Gomes. Faculty of Biological and Health Sciences, Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM, Rodovia MGT 367 - Km 583. n. 5000, Alto da Jacuba, Diamantina, MG 39100-000, Brazil.
+ Goulart-Silva, Francemilson. Institute of Biomedical Sciences, Department of Physiology and Biophysics, Universidade de Sao Paulo - USP, Av. Prof. Dr. Lineu Prestes. 1524, Butanta, Sao Paulo, SP 05508-000, Brazil.
+ Esteves, Elizabethe Adriana. Faculty of Biological and Health Sciences, Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM, Rodovia MGT 367 - Km 583. n. 5000, Alto da Jacuba, Diamantina, MG 39100-000, Brazil. Electronic address: elizabethe.esteves@ufvjm.edu.br.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ *Blood Glucose/me [Metabolism]
+ *CD36 Antigens/me [Metabolism]
+ Cadherins/me [Metabolism]
+ *Carotenoids/pd [Pharmacology]
+ Diet, High-Fat
+ Energy Intake
+ Ericales/ch [Chemistry]
+ Fatty Acids/me [Metabolism]
+ *Glucose Transporter Type 5/me [Metabolism]
+ Glycemic Control
+ *Hyperglycemia/dt [Drug Therapy]
+ Hyperglycemia/et [Etiology]
+ Hyperglycemia/pa [Pathology]
+ *Intestinal Mucosa/de [Drug Effects]
+ Intestinal Mucosa/pa [Pathology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/co [Complications]
+ *Plant Oils/pd [Pharmacology]
+Keyword Heading
+ Caryocar brasiliense
+ High-fat diet
+ Nutrient transporter
+ Obesity
+ Pequi oil
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Intestinal nutrient absorption plays a vital role in developing obesity, and nutrient transporters expressed in the enterocytes facilitate this process. Moreover, previous studies have shown that specific foods and diets can affect their cell levels. Herein, we investigated the effects of pequi oil (PO), which is high in several bioactive compounds, on intestinal nutrient transporter levels as well as on intestinal morphology and metabolic biomarkers.
+
+ MAIN METHODS: Groups of male C57BL/6 mice were fed either a standard (C) or a high-fat diet (HFD) and pequi oil (CP and HFDP with PO by gavage at 150 mg/day) for eight weeks. Food intake and body weight were monitored, serum metabolic biomarkers, intestinal transporter levels and histological analyses were performed.
+
+ KEY FINDINGS: PO increased caloric intake without increasing body or fat mass regardless of diet. The HFD group treated with PO reduced fasting blood glucose and villus width. PO did not affect GLUT2, L-FABP, FATP4, NPC1L1, NHE3 or PEPT1 content in CP or HFDP groups. GLUT5 and FAT/CD36 levels were reduced in both CP and HFDP.
+
+ SIGNIFICANCE: Our data suggest that PO attenuated monosaccharide and fatty acid absorption, contributing to lower fasting glycemia and higher food intake without affecting body weight or visceral fat of high-fat feed mice. Copyright © 2021 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (CD36 Antigens). 0 (Cadherins). 0 (Cd36 protein, mouse). 0 (Fatty Acids). 0 (Glucose Transporter Type 5). 0 (Plant Oils). 0 (Slc2a5 protein, mouse). 36-88-4 (Carotenoids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.lfs.2021.119672
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Evangelista-Silva&issn=0024-3205&title=Life+Sciences&atitle=Intestinal+GLUT5+and+FAT%2FCD36+transporters+and+blood+glucose+are+reduced+by+a+carotenoid%2FMUFA-rich+oil+in+high-fat+fed+mice.&volume=279&issue=&spage=119672&epage=&date=2021&doi=10.1016%2Fj.lfs.2021.119672&pmid=34097971&sid=OVID:medline
+
+<833>
+Unique Identifier
+ 34093556
+Title
+ In Patients With Obesity, the Number of Adipose Tissue Mast Cells Is Significantly Lower in Subjects With Type 2 Diabetes.
+Source
+ Frontiers in Immunology. 12:664576, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lopez-Perez D; Redruello-Romero A; Garcia-Rubio J; Arana C; Garcia-Escudero LA; Tamayo F; Puentes-Pardo JD; Moreno-SanJuan S; Salmeron J; Blanco A; Galvez J; Leon J; Carazo A
+Authors Full Name
+ Lopez-Perez, David; Redruello-Romero, Anais; Garcia-Rubio, Jesus; Arana, Carlos; Garcia-Escudero, Luis A; Tamayo, Francisco; Puentes-Pardo, Jose D; Moreno-SanJuan, Sara; Salmeron, Javier; Blanco, Armando; Galvez, Julio; Leon, Josefa; Carazo, Angel.
+Institution
+ Lopez-Perez, David. Department of Pharmacology, Faculty of Pharmacy, University of Granada, Granada, Spain.
+ Lopez-Perez, David. Research Unit, Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
+ Redruello-Romero, Anais. Research Unit, Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
+ Garcia-Rubio, Jesus. Surgery Unit, San Cecilio University Hospital, Granada, Spain.
+ Arana, Carlos. Endocrinology and Nutrition Unit, Virgen de las Nieves University Hospital, Granada, Spain.
+ Garcia-Escudero, Luis A. Department of Statistics and Operative Research, Faculty of Sciences, University of Valladolid, Valladolid, Spain.
+ Tamayo, Francisco. Surgery Unit, San Cecilio University Hospital, Granada, Spain.
+ Puentes-Pardo, Jose D. Department of Pharmacology, Faculty of Pharmacy, University of Granada, Granada, Spain.
+ Puentes-Pardo, Jose D. Research Unit, Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
+ Moreno-SanJuan, Sara. Cytometry and Microscopy Research Service, Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
+ Salmeron, Javier. Gastroenterology Unit, San Cecilio University Hospital, Granada, Spain.
+ Blanco, Armando. Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain.
+ Galvez, Julio. Department of Pharmacology, Faculty of Pharmacy, University of Granada, Granada, Spain.
+ Galvez, Julio. Research Unit, Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
+ Galvez, Julio. Centro de Investigacion Biomedica En Red para Enfermedades Hepaticas y Digestivas (CIBER-EHD), Center for Biomedical Research, University of Granada, Granada, Spain.
+ Leon, Josefa. Research Unit, Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
+ Carazo, Angel. Research Unit, Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
+ Carazo, Angel. Clinical Management Unit of Digestive Disease, San Cecilio University Hospital, Granada, Spain.
+MeSH Subject Headings
+ Adipogenesis
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pa [Pathology]
+ Adipose Tissue, White/me [Metabolism]
+ Adipose Tissue, White/pa [Pathology]
+ Biomarkers
+ *Cell Count
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2/pa [Pathology]
+ Humans
+ Immunophenotyping
+ Intestinal Mucosa/im [Immunology]
+ Intestinal Mucosa/me [Metabolism]
+ *Mast Cells/pa [Pathology]
+ Neovascularization, Physiologic
+ Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+Keyword Heading
+ T2D
+ adipogenesis
+ adipose tissue
+ angiogenesis
+ flow cytometry
+ inflammation
+ mast cell
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Type 2 diabetes (T2D) is a rising global health problem mainly caused by obesity and a sedentary lifestyle. In healthy individuals, white adipose tissue (WAT) has a relevant homeostatic role in glucose metabolism, energy storage, and endocrine signaling. Mast cells contribute to these functions promoting WAT angiogenesis and adipogenesis. In patients with T2D, inflammation dramatically impacts WAT functioning, which results in the recruitment of several leukocytes, including monocytes, that enhance this inflammation. Accordingly, the macrophages population rises as the WAT inflammation increases during the T2D status worsening. Since mast cell progenitors cannot arrive at WAT, the amount of WAT mast cells depends on how the new microenvironment affects progenitor and differentiated mast cells. Here, we employed a flow cytometry-based approach to analyze the number of mast cells from omental white adipose tissue (o-WAT) and subcutaneous white adipose tissue (s-WAT) in a cohort of 100 patients with obesity. Additionally, we measured the number of mast cell progenitors in a subcohort of 15 patients. The cohort was divided in three groups: non-T2D, pre-T2D, and T2D. Importantly, patients with T2D have a mild condition (HbA1c <7%). The number of mast cells and mast cell progenitors was lower in patients with T2D in both o-WAT and s-WAT in comparison to subjects from the pre-T2D and non-T2D groups. In the case of mast cells in o-WAT, there were statistically significant differences between non-T2D and T2D groups (p = 0.0031), together with pre-T2D and T2D groups (p=0.0097). However, in s-WAT, the differences are only between non-T2D and T2D groups (p=0.047). These differences have been obtained with patients with a mild T2D condition. Therefore, little changes in T2D status have a huge impact on the number of mast cells in WAT, especially in o-WAT. Due to the importance of mast cells in WAT physiology, their decrease can reduce the capacity of WAT, especially o-WAT, to store lipids and cause hypoxic cell deaths that will trigger inflammation. Copyright © 2021 Lopez-Perez, Redruello-Romero, Garcia-Rubio, Arana, Garcia-Escudero, Tamayo, Puentes-Pardo, Moreno-SanJuan, Salmeron, Blanco, Galvez, Leon and Carazo.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffimmu.2021.664576
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lopez-Perez&issn=1664-3224&title=Frontiers+in+Immunology&atitle=In+Patients+With+Obesity%2C+the+Number+of+Adipose+Tissue+Mast+Cells+Is+Significantly+Lower+in+Subjects+With+Type+2+Diabetes.&volume=12&issue=&spage=664576&epage=&date=2021&doi=10.3389%2Ffimmu.2021.664576&pmid=34093556&sid=OVID:medline
+
+<834>
+Unique Identifier
+ 34088886
+Title
+ Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity.
+Source
+ Aging. 13(11):14806-14815, 2021 06 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chumakova G; Gritsenko O; Gruzdeva O; Dyleva Y
+Authors Full Name
+ Chumakova, Galina; Gritsenko, Olesya; Gruzdeva, Olga; Dyleva, Yulia.
+Institution
+ Chumakova, Galina. Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
+ Chumakova, Galina. Federal State Budgetary Educational Institution of Higher Education, "Altai State Medical University" of the Ministry of Health of the Russian Federation, Barnaul, Russia.
+ Gritsenko, Olesya. Regional State Budgetary Healthcare Institution of Altai Regional Cardiological Dispensary, Barnaul, Russia.
+ Gruzdeva, Olga. Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
+ Dyleva, Yulia. Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
+MeSH Subject Headings
+ Adipokines/me [Metabolism]
+ Adipose Tissue/dg [Diagnostic Imaging]
+ Adipose Tissue/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ Fibrosis
+ Humans
+ Inflammation Mediators/me [Metabolism]
+ *Lipids/ae [Adverse Effects]
+ Male
+ Middle Aged
+ *Myocardium/pa [Pathology]
+ Neurotransmitter Agents
+ *Obesity/pa [Pathology]
+ Pericardium/dg [Diagnostic Imaging]
+ *Pericardium/pa [Pathology]
+ Risk Factors
+ Statistics, Nonparametric
+Keyword Heading
+ cardiac fibrosis markers
+ epicardial obesity
+ myocardial fibrosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Myocardial fibrosis is considered a key pathological process in the development of cardiovascular diseases. In epicardial obesity (EO), the main cause of fibrosis development is lipotoxic myocardial damage. It is important to detect myocardial fibrosis at an early stage, using non-invasive diagnostic methods. According to the results of echocardiography (ECG), 110 men with general obesity were divided into the following two groups: Group I with epicardial fat thickness (tEAT) >= 7 mm (n = 70) and Group II with tEAT < 7 mm (n = 40) without diastolic dysfunction. The levels of metabolic factors, pro-inflammatory cytokines, adipokines, and free fatty acids (FFA), profibrotic markers were determined in both groups. In Group I, the level of interleukin (IL)-6, C-reactive protein, and tumor necrosis factor (TNF)-alpha increased and that of leptin and adiponectin decreased compared with those in Group II. There was an increase in the level of all studied profibrotic factors in Group I. The level of TNF-alpha and IL-6 showed a positive correlation with the level of leptin and FFA and a negative correlation with the level of adiponectin. We also observed a relationship between the level of collagen, transforming growth factor (TGF)-beta, and metalloproteinase (MMP)-3 and EO. Our results showed that confirmed EO correlates with not only disadipocytosis and increased levels of pro-inflammatory cytokines, but also increased levels of profibrotic factors. This suggests that the studied markers of fibrosis may be used to determine preclinical cardiac fibrosis with lipotoxic myocardial damage in patients with EO.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Lipids). 0 (Neurotransmitter Agents).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.18632%2faging.203148
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chumakova&issn=1945-4589&title=Aging&atitle=Analysis+of+probable+lipotoxic+damage+and+myocardial+fibrosis+in+epicardial+obesity.&volume=13&issue=11&spage=14806&epage=14815&date=2021&doi=10.18632%2Faging.203148&pmid=34088886&sid=OVID:medline
+
+<835>
+Unique Identifier
+ 34085602
+Title
+ Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.
+Source
+ Adipocyte. 10(1):310-321, 2021 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dong Z; Lei X; Kujawa SA; Bolu N; Zhao H; Wang C
+Authors Full Name
+ Dong, Zhiyong; Lei, Xinyi; Kujawa, Stacy A; Bolu, NaciEmre; Zhao, Hong; Wang, Cunchuan.
+Institution
+ Dong, Zhiyong. Department of Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
+ Lei, Xinyi. Department of Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
+ Kujawa, Stacy A. Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
+ Bolu, NaciEmre. Department of Medicine, Istanbul University Istanbul Faculty of Medicine, Fatih, Turkey.
+ Zhao, Hong. Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
+ Wang, Cunchuan. Department of Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
+MeSH Subject Headings
+ *Acetyl-CoA Carboxylase/ge [Genetics]
+ Biomarkers/an [Analysis]
+ *CD36 Antigens/ge [Genetics]
+ *Collagen Type IV/ge [Genetics]
+ Computational Biology
+ *Diabetes Mellitus, Type 2/ge [Genetics]
+ Gene Expression Profiling
+ *Glutamate-Ammonia Ligase/ge [Genetics]
+ Humans
+ *Obesity/ge [Genetics]
+ Software
+Keyword Heading
+ Obesity
+ adipose tissue
+ bioinformatics analysis
+ core molecular markers
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objectives Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation. The aim of this study is to discover the adipocyte genes and pathways involved in obesity and type 2 diabetes using bioinformatics analysis. Methods The GSE27951 gene expression profile was obtained. Software and online tools (STRING, Cytoscape, BioGPS, CTD, and FunRich) were used to identify core genes.21 human subcutaneous adipose samples, with 10 from type 2 diabetic patients and 11 from normal controls, were included in these analyses. Results 184 differentially expressed genes (DEGs) including 42 up-regulated genes and 142 down-regulated genes were found to be enriched in metabolism, receptor activity, collagen type IV and glutamine biosynthesis I pathway by using the enrichment analysis. Seven hub genes were identified from the PPI network using various software (Cytoscape, STRING, BioGPS, and CTD). Four core genes (COL4A2, ACACB, GLUL, and CD36) were found to be highly expressed in subcutaneous adipose tissue of obese patients accompanying type 2 diabetes. Conclusion COL4A2, ACACB, GLUL and CD36 might be the core molecular biomarkers of obesity in patients with or without type 2 diabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CD36 Antigens). 0 (COL4A2 protein, human). 0 (Collagen Type IV). EC 6-3-1-2 (GLUL protein, human). EC 6-3-1-2 (Glutamate-Ammonia Ligase). EC 6-4-1-2 (ACACB protein, human). EC 6-4-1-2 (Acetyl-CoA Carboxylase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1080%2f21623945.2021.1933297
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dong&issn=2162-3945&title=Adipocyte&atitle=Identification+of+core+gene+in+obese+type+2+diabetes+patients+using+bioinformatics+analysis.&volume=10&issue=1&spage=310&epage=321&date=2021&doi=10.1080%2F21623945.2021.1933297&pmid=34085602&sid=OVID:medline
+
+<836>
+Unique Identifier
+ 34084151
+Title
+ Nuclear Magnetic Resonance Derived Biomarkers for Evaluating Cardiometabolic Risk in Youth and Young Adults Across the Spectrum of Glucose Tolerance.
+Source
+ Frontiers in Endocrinology. 12:665292, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chung ST; Matta ST; Meyers AG; Cravalho CK; Villalobos-Perez A; Dawson JM; Sharma VR; Sampson ML; Otvos JD; Magge SN
+Authors Full Name
+ Chung, Stephanie T; Matta, Samantha T; Meyers, Abby G; Cravalho, Celeste K; Villalobos-Perez, Alfredo; Dawson, Joshua M; Sharma, Vandhna R; Sampson, Maureen L; Otvos, James D; Magge, Sheela N.
+Institution
+ Chung, Stephanie T. Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
+ Matta, Samantha T. Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
+ Meyers, Abby G. Department of Endocrinology and Diabetes, Children's National Hospital, Washington, DC, United States.
+ Cravalho, Celeste K. Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
+ Villalobos-Perez, Alfredo. Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
+ Dawson, Joshua M. Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
+ Sharma, Vandhna R. Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
+ Sampson, Maureen L. National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD, United States.
+ Otvos, James D. Laboratory Corporation of America Holdings (LabCorp), Morrisville, NC, United States.
+ Magge, Sheela N. Division of Pediatric Endocrinology and Diabetes, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Amino Acids, Branched-Chain/me [Metabolism]
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ *Cardiovascular Diseases/pa [Pathology]
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ *Lipoproteins/me [Metabolism]
+ *Magnetic Resonance Spectroscopy/mt [Methods]
+ Male
+ Obesity/pp [Physiopathology]
+ Prognosis
+ Thinness/pp [Physiopathology]
+ Young Adult
+Keyword Heading
+ GlycA
+ NMR
+ cardiometabolic risk
+ glucose tolerance
+ insulin resistance
+ lipoprotein insulin resistance index
+ youth
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Youth with obesity have an increased risk for cardiometabolic disease, but identifying those at highest risk remains a challenge. Four biomarkers that might serve this purpose are "by products" of clinical NMR LipoProfile R lipid testing: LPIR (Lipoprotein Insulin Resistance Index), GlycA (inflammation marker), BCAA (total branched-chain amino acids), and glycine. All are strongly related to insulin resistance and type 2 diabetes (T2DM) in adults (glycine inversely) and are independent of biological and methodological variations in insulin assays. However, their clinical utility in youth is unclear. We compared fasting levels of these biomarkers in 186 youth (42 lean normal glucose tolerant (NGT), 88 obese NGT, 23 with prediabetes (PreDM), and 33 with T2DM. All four biomarkers were associated with obesity and glycemia in youth. LPIR and GlycA were highest in youth with PreDM and T2DM, whereas glycine was lowest in youth with T2DM. While all four were correlated with HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), LPIR had the strongest correlation (LPIR: r = 0.6; GlycA: r = 0.4, glycine: r = -0.4, BCAA: r = 0.2, all P < 0.01). All four markers correlated with HbA1c (LPIR, GlycA, BCAA: r >= 0.3 and glycine: r = -0.3, all P < 0.001). In multi-variable regression models, LPIR, GlycA, and glycine were independently associated with HOMA-IR (Adjusted R2 = 0.473, P < 0.001) and LPIR, glycine, and BCAA were independently associated with HbA1c (Adjusted R2 = 0.33, P < 0.001). An LPIR index of >44 was associated with elevated blood pressure, BMI, and dyslipidemia. Plasma NMR-derived markers were related to adverse markers of cardiometabolic risk in youth. LPIR, either alone or in combination with GlycA, should be explored as a non-insulin dependent predictive tool for development of insulin resistance and diabetes in youth.
+
+ Clinical Trial Registration: Clinicaltrials.gov, identifier NCT:02960659. Copyright At least a portion of this work is authored by Stephanie T. Chung on behalf of the U.S. Government and, as regards Dr. Chung and the U.S. Government, is not subject to copyright protection in the United States.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipoproteins).
+Publication Type
+ Journal Article. Observational Study. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.665292
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chung&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Nuclear+Magnetic+Resonance+Derived+Biomarkers+for+Evaluating+Cardiometabolic+Risk+in+Youth+and+Young+Adults+Across+the+Spectrum+of+Glucose+Tolerance.&volume=12&issue=&spage=665292&epage=&date=2021&doi=10.3389%2Ffendo.2021.665292&pmid=34084151&sid=OVID:medline
+
+<837>
+Unique Identifier
+ 34080783
+Title
+ Prevalence of metabolic syndrome in patients with rheumatoid arthritis in eastern China-A hospital based study.
+Source
+ International Journal of Rheumatic Diseases. 24(9):1121-1126, 2021 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kong CY; Wang CL; Niu KJ; Qi W
+Author NameID
+ Qi, Wufang; ORCID: https://orcid.org/0000-0003-0774-3934
+Authors Full Name
+ Kong, Chun-Yu; Wang, Chang-Lei; Niu, Kai-Jun; Qi, Wufang.
+Institution
+ Kong, Chun-Yu. Tianjin First Center Hospital, Tianjin, China.
+ Wang, Chang-Lei. Tianjin University of Traditional Chinese Medicine, Tianjin, China.
+ Niu, Kai-Jun. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
+ Niu, Kai-Jun. Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.
+ Qi, Wufang. Tianjin First Center Hospital, Tianjin, China.
+MeSH Subject Headings
+ Arthritis, Rheumatoid/bl [Blood]
+ Arthritis, Rheumatoid/di [Diagnosis]
+ *Arthritis, Rheumatoid/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ China/ep [Epidemiology]
+ Complement C3/an [Analysis]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/ep [Epidemiology]
+ Female
+ Glucocorticoids/tu [Therapeutic Use]
+ Hospitals
+ Humans
+ Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Time Factors
+Keyword Heading
+ influencing factors
+ metabolic syndrome
+ prevalence
+ rheumatoid arthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The purpose of this hospital clinic based study was to evaluate the potential risk factors associated with the prevalence of MetS in RA population.
+
+ METHODS: From January 2015 to October 2018, 717 patients with RA and 717 healthy controls who were treated or performed physical examination in Tianjin First Central Hospital were enrolled in this study. The basic disease diagnoses were recorded. A questionnaire was performed on all participants to assess the demographic details of the RA cohort. Moreover, laboratory indicators related to glucose and lipid metabolism in patients with RA were also detected. The potential risk factors for MetS were also analyzed.
+
+ RESULTS: The prevalence of MetS were 31.2% and 34.2% in case and control groups, respectively (P = .22). There were lower levels of HDL-C, obesity, TG, LDL-C and TC in case group than control group (all P < .05). The hypertension levels in healthy controls was decreased in compared with patients with RA (P < .05). Nevertheless, in patients with RA, complement 3 (OR: 1.02; 95% CI: 1.01-1.03, P = .007) and less glucocorticoids use (OR: 0.63, 95% CI: 0.39-0.99, P = .046) were associated with MetS.
+
+ CONCLUSION: The prevalence of MetS was not associated with RA. Complement 3 may be associated with the higher prevalence of MetS in patients with RA. Glucocorticoids treatment may be associated with MetS. Copyright © 2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C3 protein, human). 0 (Complement C3). 0 (Glucocorticoids). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1111%2f1756-185X.14148
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kong&issn=1756-1841&title=International+Journal+of+Rheumatic+Diseases&atitle=Prevalence+of+metabolic+syndrome+in+patients+with+rheumatoid+arthritis+in+eastern+China-A+hospital+based+study.&volume=24&issue=9&spage=1121&epage=1126&date=2021&doi=10.1111%2F1756-185X.14148&pmid=34080783&sid=OVID:medline
+
+<838>
+Unique Identifier
+ 34077948
+Title
+ Metabolism of Epithelial Cells in Health and Allergic Disease: Collegium Internationale Allergologicum Update 2021. [Review]
+Source
+ International Archives of Allergy & Immunology. 182(8):663-678, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Queener AM; Chiarella SE; Cuervo-Pardo L; Coden ME; Abdala-Valencia H; Berdnikovs S
+Authors Full Name
+ Queener, Ashley M; Chiarella, Sergio E; Cuervo-Pardo, Lyda; Coden, Mackenzie E; Abdala-Valencia, Hiam; Berdnikovs, Sergejs.
+Institution
+ Queener, Ashley M. Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
+ Chiarella, Sergio E. Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
+ Chiarella, Sergio E. Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
+ Cuervo-Pardo, Lyda. Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
+ Cuervo-Pardo, Lyda. Division of Rheumatology, Allergy and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, Florida, USA.
+ Coden, Mackenzie E. Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
+ Abdala-Valencia, Hiam. Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
+ Berdnikovs, Sergejs. Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Diabetes Mellitus/me [Metabolism]
+ *Disease Susceptibility
+ *Energy Metabolism
+ *Epithelial Cells/me [Metabolism]
+ *Homeostasis
+ Humans
+ *Hypersensitivity/et [Etiology]
+ *Hypersensitivity/me [Metabolism]
+ Insulin Resistance
+ Metabolic Networks and Pathways
+ Mitochondria
+ Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Signal Transduction
+Keyword Heading
+ Allergy
+ Arachidonate metabolism
+ Arginine
+ Asthma
+ Atopic dermatitis
+ Autophagy
+ Dyslipidemia
+ Epithelium
+ Glucose
+ Insulin
+ Metabolism
+ Mitochondria
+ Nitric oxide
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Concomitant dramatic increase in prevalence of allergic and metabolic diseases is part of a modern epidemic afflicting technologically advanced societies. While clinical evidence points to clear associations between various metabolic factors and atopic disease, there is still a very limited understanding of the mechanisms that link the two. Dysregulation of central metabolism in metabolic syndrome, obesity, diabetes, and dyslipidemia has a systemic impact on multiple tissues and organs, including cells of the epithelial barrier. While much of epithelial research in allergy has focused on the immune-driven processes, a growing number of recent studies have begun to elucidate the role of metabolic components of disease. This review will revisit clinical evidence for the relationship between metabolic and allergic diseases, as well as discuss potential mechanisms driving metabolic dysfunction of the epithelial barrier. Among them, novel studies highlight links between dysregulation of the insulin pathway, glucose metabolism, and loss of epithelial differentiation in asthma. Studies of mitochondrial structure and bioenergetics in lean and obese asthmatic phenotypes recently came to light to provide a novel framework linking changes in tricarboxylic acid cycle and oxidative phosphorylation with arginine metabolism and nitric oxide bioavailability. New research established connections between arachidonate metabolism, autophagy, and airway disease, as well as systemic dyslipidemia in atopic dermatitis and ceramide changes in the epidermis. Taken together, studies of metabolism have a great potential to open doors to a new class of therapeutic strategies, better characterization of disease endotypes, as well as enable a systems biology approach to mechanisms of allergic disease. Copyright © 2021 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1159%2f000516809
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Queener&issn=1018-2438&title=International+Archives+of+Allergy+%26+Immunology&atitle=Metabolism+of+Epithelial+Cells+in+Health+and+Allergic+Disease%3A+Collegium+Internationale+Allergologicum+Update+2021.&volume=182&issue=8&spage=663&epage=678&date=2021&doi=10.1159%2F000516809&pmid=34077948&sid=OVID:medline
+
+<839>
+Unique Identifier
+ 34071774
+Title
+ Visceral Adipose Tissue Displays Unique Metabolomic Fingerprints in Obesity, Pre-Diabetes and Type 2 Diabetes.
+Source
+ International Journal of Molecular Sciences. 22(11), 2021 May 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Morais T; Seabra AL; Patricio BG; Guimaraes M; Nora M; Oliveira PF; Alves MG; Monteiro MP
+Author NameID
+ Morais, Tiago; ORCID: https://orcid.org/0000-0003-4905-706X
+ Seabra, Alexandre L; ORCID: https://orcid.org/0000-0002-9474-9148
+ Oliveira, Pedro F; ORCID: https://orcid.org/0000-0002-4989-5699
+ Alves, Marco G; ORCID: https://orcid.org/0000-0001-7635-783X
+ Monteiro, Mariana P; ORCID: https://orcid.org/0000-0002-0662-1831
+Authors Full Name
+ Morais, Tiago; Seabra, Alexandre L; Patricio, Barbara G; Guimaraes, Marta; Nora, Mario; Oliveira, Pedro F; Alves, Marco G; Monteiro, Mariana P.
+Institution
+ Morais, Tiago. Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal.
+ Morais, Tiago. Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, 4050-313 Porto, Portugal.
+ Morais, Tiago. Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
+ Seabra, Alexandre L. Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal.
+ Seabra, Alexandre L. Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, 4050-313 Porto, Portugal.
+ Seabra, Alexandre L. Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
+ Patricio, Barbara G. Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal.
+ Patricio, Barbara G. Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, 4050-313 Porto, Portugal.
+ Patricio, Barbara G. Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
+ Guimaraes, Marta. Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal.
+ Guimaraes, Marta. Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, 4050-313 Porto, Portugal.
+ Guimaraes, Marta. Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
+ Guimaraes, Marta. Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, 4520-220 Santa Maria da Feira, Portugal.
+ Nora, Mario. Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal.
+ Nora, Mario. Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, 4050-313 Porto, Portugal.
+ Nora, Mario. Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, 4520-220 Santa Maria da Feira, Portugal.
+ Oliveira, Pedro F. QOPNA & LAQV, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
+ Alves, Marco G. Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal.
+ Alves, Marco G. Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, 4050-313 Porto, Portugal.
+ Alves, Marco G. Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
+ Monteiro, Mariana P. Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal.
+ Monteiro, Mariana P. Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, 4050-313 Porto, Portugal.
+ Monteiro, Mariana P. Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adult
+ Aged
+ Biomarkers
+ Body Weights and Measures
+ Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Disease Susceptibility
+ Energy Metabolism
+ Female
+ Humans
+ *Intra-Abdominal Fat/me [Metabolism]
+ Male
+ *Metabolome
+ Metabolomics/mt [Methods]
+ *Metabolomics
+ Middle Aged
+ Models, Biological
+ *Obesity/me [Metabolism]
+ *Prediabetic State/me [Metabolism]
+ Young Adult
+Keyword Heading
+ adipose tissue
+ metabolomics
+ obesity
+ pre-diabetes
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Visceral adipose tissue (VAT) metabolic profiling harbors the potential to disentangle molecular changes underlying obesity-related dysglycemia. In this study, the VAT exometabolome of subjects with obesity and different glycemic statuses are analyzed. The subjects (n = 19) are divided into groups according to body mass index and glycemic status: subjects with obesity and euglycemia (Ob+NGT, n = 5), subjects with obesity and pre-diabetes (Ob+Pre-T2D, n = 5), subjects with obesity and type 2 diabetes under metformin treatment (Ob+T2D, n = 5) and subjects without obesity and with euglycemia (Non-Ob, n = 4), used as controls. VATs are incubated in culture media and extracellular metabolite content is determined by proton nuclear magnetic resonance (1H-NMR). Glucose consumption is not different between the groups. Pyruvate and pyroglutamate consumption are significantly lower in all groups of subjects with obesity compared to Non-Ob, and significantly lower in Ob+Pre-T2D as compared to Ob+NGT. In contrast, isoleucine consumption is significantly higher in all groups of subjects with obesity, particularly in Ob+Pre-T2D, compared to Non-Ob. Acetate production is also significantly lower in Ob+Pre-T2D compared to Non-Ob. In sum, the VAT metabolic fingerprint is associated with pre-diabetes and characterized by higher isoleucine consumption, accompanied by lower acetate production and pyruvate and pyroglutamate consumption. We propose that glucose metabolism follows different fates within the VAT, depending on the individuals' health status.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22115695
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Morais&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Visceral+Adipose+Tissue+Displays+Unique+Metabolomic+Fingerprints+in+Obesity%2C+Pre-Diabetes+and+Type+2+Diabetes.&volume=22&issue=11&spage=5695&epage=&date=2021&doi=10.3390%2Fijms22115695&pmid=34071774&sid=OVID:medline
+
+<840>
+Unique Identifier
+ 34069449
+Title
+ Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding.
+Source
+ Nutrients. 13(5), 2021 May 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Persinger A; Butawan M; Faietti M; Pryke A; Rose K; van der Merwe M; Bloomer RJ; Puppa MJ
+Author NameID
+ van der Merwe, Marie; ORCID: https://orcid.org/0000-0001-5683-4790
+Authors Full Name
+ Persinger, Aaron; Butawan, Matthew; Faietti, Martina; Pryke, Ashley; Rose, Kyley; van der Merwe, Marie; Bloomer, Richard J; Puppa, Melissa J.
+Institution
+ Persinger, Aaron. College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USA.
+ Butawan, Matthew. College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USA.
+ Faietti, Martina. College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USA.
+ Pryke, Ashley. College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USA.
+ Rose, Kyley. College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USA.
+ van der Merwe, Marie. College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USA.
+ Bloomer, Richard J. College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USA.
+ Puppa, Melissa J. College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USA.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Body Weight
+ *Fasting
+ *Feeding Behavior
+ Hindlimb
+ Humans
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mitochondria/me [Metabolism]
+ Muscle, Skeletal/me [Metabolism]
+ *Muscles/me [Metabolism]
+ Obesity
+ Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/me [Metabolism]
+ RNA, Messenger/me [Metabolism]
+Keyword Heading
+ aerobic training
+ skeletal muscle metabolism
+ time-restricted feeding
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Time-restricted feeding (TRF) is becoming a popular way of eating in physically active populations, despite a lack of research on metabolic and performance outcomes as they relate to the timing of food consumption in relation to the time of exercise. The purpose of this study was to determine if the timing of feeding/fasting after exercise training differently affects muscle metabolic flexibility and response to an acute bout of exercise. Male C57BL/6 mice were randomized to one of three groups for 8 weeks. The control had ad libitum access to food before and after exercise training. TRF-immediate had immediate access to food for 6 h following exercise training and the TRF-delayed group had access to food 5-h post exercise for 6 h. The timing of fasting did not impact performance in a run to fatigue despite TRF groups having lower hindlimb muscle mass. TRF-delayed had lower levels of muscle HSL mRNA expression and lower levels of PGC-1alpha expression but displayed no changes in electron transport chain enzymes. These results suggest that in young populations consuming a healthy diet and exercising, the timing of fasting may not substantially impact metabolic flexibility and running performance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha). 0 (Ppargc1a protein, mouse). 0 (RNA, Messenger).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13051717
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Persinger&issn=2072-6643&title=Nutrients&atitle=Effects+of+Feeding+Time+on+Markers+of+Muscle+Metabolic+Flexibility+Following+Acute+Aerobic+Exercise+in+Trained+Mice+Undergoing+Time+Restricted+Feeding.&volume=13&issue=5&spage=&epage=&date=2021&doi=10.3390%2Fnu13051717&pmid=34069449&sid=OVID:medline
+
+<841>
+Unique Identifier
+ 34067683
+Title
+ Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients.
+Source
+ International Journal of Molecular Sciences. 22(10), 2021 May 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elemam NM; Hasswan H; Aljaibeji H; Sulaiman N
+Author NameID
+ Elemam, Noha Mousaad; ORCID: https://orcid.org/0000-0002-3586-6731
+ Aljaibeji, Hayat; ORCID: https://orcid.org/0000-0002-1716-0743
+Authors Full Name
+ Elemam, Noha Mousaad; Hasswan, Hind; Aljaibeji, Hayat; Sulaiman, Nabil.
+Institution
+ Elemam, Noha Mousaad. Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
+ Hasswan, Hind. Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
+ Aljaibeji, Hayat. Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
+ Aljaibeji, Hayat. Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
+ Sulaiman, Nabil. Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
+ Sulaiman, Nabil. Department of Family Medicine, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
+ Sulaiman, Nabil. Baker/IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
+MeSH Subject Headings
+ Adult
+ *Angiotensin-Converting Enzyme 2/bl [Blood]
+ Angiotensin-Converting Enzyme 2/ge [Genetics]
+ Angiotensin-Converting Enzyme 2/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ COVID-19/bl [Blood]
+ COVID-19/co [Complications]
+ COVID-19/ge [Genetics]
+ *Diabetes Complications/bl [Blood]
+ Diabetes Complications/ge [Genetics]
+ Diabetes Complications/vi [Virology]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Diabetes Mellitus, Type 2/vi [Virology]
+ Down-Regulation
+ Female
+ Gene Expression Regulation/ge [Genetics]
+ Humans
+ Male
+ *MicroRNAs/bl [Blood]
+ MicroRNAs/ge [Genetics]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+Keyword Heading
+ biomarkers
+ miRNAs
+ soluble ACE2
+ type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The global coronavirus disease 2019 (COVID-19) pandemic was associated with multiple organ failure and comorbidities, such as type 2 diabetes mellitus (T2DM). Risk factors, such as age, gender, and obesity, were associated with COVID-19 infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to use several host receptors for viral entry, such as angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) in the lung and other organs. However, ACE2 could be shed from the surface to be soluble ACE2 (sACE2) in the circulation. The epigenetic factors affecting ACE2 expression include a type of small non-coding RNAs called microRNAs (miRNAs). In this study, we aimed at exploring the status of the sACE2 as well as serum levels of several upstream novel miRNAs as non-invasive biomarkers that might have a potential role in T2DM patients. Serum samples were collected from 50 T2DM patients and 50 healthy controls, and sACE2 levels were quantified using enzyme-linked immunosorbent assay (ELISA). Also, RNA was extracted, and TaqMan miRNA reverse transcription quantitative PCR (RT-qPCR) was performed to measure serum miRNA levels. Our results revealed that sACE2 is decreased in the T2DM patients and is affected by age, gender, and obesity level. Additionally, 4 miRNAs, which are revealed by in silico analysis to be potentially upstream of ACE2 were detectable in the serum. Among them, miR-421 level was found to be decreased in the serum of diabetic patients, regardless of the presence or absence of diabetic complications, as well as being differential in various body mass index (BMI) groups. The other 3 miRNAs (miR-3909, miR-212-5p, and miR-4677-3p) showed associations with multiple factors including age, gender, BMI, and serum markers, in addition to being correlated to each other. In conclusion, our study reveals a decline in the circulating serum levels of sACE2 in T2DM patients and identified 4 novel miRNAs that were associated with T2DM, which are influenced by different clinical and demographic factors.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN212 microRNA, human). 0 (MIRN421 microRNA, human). 0 (MIRN46773p microRNA, human). 0 (MicroRNAs). EC 3-4-17-23 (Angiotensin-Converting Enzyme 2).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22105263
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elemam&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Circulating+Soluble+ACE2+and+Upstream+microRNA+Expressions+in+Serum+of+Type+2+Diabetes+Mellitus+Patients.&volume=22&issue=10&spage=5263&epage=&date=2021&doi=10.3390%2Fijms22105263&pmid=34067683&sid=OVID:medline
+
+<842>
+Unique Identifier
+ 34066330
+Title
+ Obesity Development and Signs of Metabolic Abnormalities in Young Gottingen Minipigs Consuming Energy Dense Diets Varying in Carbohydrate Quality.
+Source
+ Nutrients. 13(5), 2021 May 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Curtasu MV; Skou Hedemann M; Nygaard Laerke H; Bach Knudsen KE
+Author NameID
+ Curtasu, Mihai Victor; ORCID: https://orcid.org/0000-0001-9823-6692
+ Skou Hedemann, Mette; ORCID: https://orcid.org/0000-0002-1164-4405
+ Nygaard Laerke, Helle; ORCID: https://orcid.org/0000-0002-0303-0745
+ Bach Knudsen, Knud Erik; ORCID: https://orcid.org/0000-0001-8345-9236
+Authors Full Name
+ Curtasu, Mihai Victor; Skou Hedemann, Mette; Nygaard Laerke, Helle; Bach Knudsen, Knud Erik.
+Institution
+ Curtasu, Mihai Victor. Department of Animal Science, Aarhus University, Blichers Alle 20, DK-8830 Tjele, Denmark.
+ Skou Hedemann, Mette. Department of Animal Science, Aarhus University, Blichers Alle 20, DK-8830 Tjele, Denmark.
+ Nygaard Laerke, Helle. Department of Animal Science, Aarhus University, Blichers Alle 20, DK-8830 Tjele, Denmark.
+ Bach Knudsen, Knud Erik. Department of Animal Science, Aarhus University, Blichers Alle 20, DK-8830 Tjele, Denmark.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ *Diet, Carbohydrate Loading/ae [Adverse Effects]
+ Diet, Carbohydrate Loading/mt [Methods]
+ Disease Models, Animal
+ Dyslipidemias/bl [Blood]
+ *Energy Intake/ph [Physiology]
+ Energy Metabolism/ph [Physiology]
+ *Fructose/ad [Administration & Dosage]
+ *Metabolic Syndrome/et [Etiology]
+ *Obesity/et [Etiology]
+ Starch/ad [Administration & Dosage]
+ Swine
+ Swine, Miniature
+ Weight Gain/de [Drug Effects]
+ Zea mays
+Keyword Heading
+ carbohydrates
+ dyslipidemia
+ gene expression
+ inflammation
+ liver metabolism
+ miniature pigs
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Consumption of fructose has been associated with a higher risk of developing obesity and metabolic syndrome (MetS). The aim of this study was to examine the long-term effects of fructose compared to starch from high-amylose maize starch (HiMaize) at ad libitum feeding in a juvenile Gottingen Minipig model with 20% of the diet provided as fructose as a high-risk diet (HR, n = 15) and 20% as HiMaize as a lower-risk control diet (LR, n = 15). The intake of metabolizable energy was on average similar (p = 0.11) among diets despite increased levels of the satiety hormone PYY measured in plasma (p = 0.0005) of the LR pigs. However, after over 20 weeks of ad libitum feeding, no difference between diets was observed in daily weight gain (p = 0.103), and a difference in BW was observed only at the end of the experiment. The ad libitum feeding promoted an obese phenotype over time in both groups with increased plasma levels of glucose (p = 0.005), fructosamine (p < 0.001), insulin (p = 0.03), and HOMA-IR (p = 0.02), whereas the clinical markers of dyslipidemia were unaffected. When compared to the LR diet, fructose did not accelerate the progression of MetS associated parameters and largely failed to change markers that indicate a stimulated de novo lipogenesis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 30237-26-4 (Fructose). 9005-25-8 (Starch).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13051560
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Curtasu&issn=2072-6643&title=Nutrients&atitle=Obesity+Development+and+Signs+of+Metabolic+Abnormalities+in+Young+Gottingen+Minipigs+Consuming+Energy+Dense+Diets+Varying+in+Carbohydrate+Quality.&volume=13&issue=5&spage=&epage=&date=2021&doi=10.3390%2Fnu13051560&pmid=34066330&sid=OVID:medline
+
+<843>
+Unique Identifier
+ 34063273
+Title
+ Risk of Iron Overload in Obesity and Implications in Metabolic Health.
+Source
+ Nutrients. 13(5), 2021 May 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moore Heslin A; O'Donnell A; Buffini M; Nugent AP; Walton J; Flynn A; McNulty BA
+Author NameID
+ Moore Heslin, Aoibhin; ORCID: https://orcid.org/0000-0001-6257-4083
+ Nugent, Anne P; ORCID: https://orcid.org/0000-0002-0206-1320
+ Walton, Janette; ORCID: https://orcid.org/0000-0003-4758-5328
+ Flynn, Albert; ORCID: https://orcid.org/0000-0002-7072-4202
+ McNulty, Breige A; ORCID: https://orcid.org/0000-0003-0841-063X
+Authors Full Name
+ Moore Heslin, Aoibhin; O'Donnell, Aisling; Buffini, Maria; Nugent, Anne P; Walton, Janette; Flynn, Albert; McNulty, Breige A.
+Institution
+ Moore Heslin, Aoibhin. UCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
+ O'Donnell, Aisling. UCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
+ Buffini, Maria. UCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
+ Nugent, Anne P. UCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
+ Nugent, Anne P. Institute for Global Food Security, Queens University Belfast, Belfast BT7 1NN, UK.
+ Walton, Janette. Department of Biological Sciences, Munster Technological University, T12 P928 Cork, Ireland.
+ Flynn, Albert. School of Food & Nutritional Sciences, University College Cork, T12 K8AF Cork, Ireland.
+ McNulty, Breige A. UCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ Adiposity/ph [Physiology]
+ Adult
+ Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Body Composition
+ Cardiometabolic Risk Factors
+ Cross-Sectional Studies
+ Female
+ Ferritins/bl [Blood]
+ Hepcidins/bl [Blood]
+ Homeostasis
+ Humans
+ Inflammation
+ Ireland/ep [Epidemiology]
+ *Iron Overload/ep [Epidemiology]
+ *Iron Overload/et [Etiology]
+ Male
+ Middle Aged
+ Nutrition Surveys
+ Obesity/co [Complications]
+ *Obesity/pp [Physiopathology]
+ Prevalence
+ Sex Factors
+ Triglycerides/bl [Blood]
+Keyword Heading
+ body fat
+ ferritin
+ hepcidin
+ inflammation
+ iron overload
+ metabolic health
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Excessive adiposity is associated with several metabolic perturbations including disturbances in iron homeostasis. Increased systemic inflammation in obesity stimulates expression of the iron regulatory hormone hepcidin, which can result in a maldistribution of bodily iron, which may be implicated in metabolic dysfunction. This study aimed to investigate the effect of adiposity and any associated inflammation on iron homeostasis and the potential implications of dysregulated iron metabolism on metabolic health. Analyses are based on a subsample from the cross-sectional Irish National Adult Nutrition Survey (2008-2010) (n = 1120). Ferritin status and risk of iron overload were determined based on established WHO ferritin ranges. Participants were classed as having a healthy % body fat or as having overfat or obesity based on age- and gender-specific % body fat ranges as determined by bioelectrical impedance. Biomarkers of iron status were examined in association with measures of body composition, serum adipocytokines and markers of metabolic health. Excessive % body fat was significantly associated with increased serum hepcidin and ferritin and an increased prevalence of severe risk of iron overload amongst males independent of dietary iron intake. Elevated serum ferritin displayed significant positive associations with serum triglycerides and markers of glucose metabolism, with an increased but non-significant presentation of metabolic risk factors amongst participants with overfat and obesity at severe risk of iron overload. Increased adiposity is associated with dysregulations in iron homeostasis, presenting as increased serum hepcidin, elevated serum ferritin and an increased risk of iron overload, with potential implications in impairments in metabolic health.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Blood Glucose). 0 (Hepcidins). 0 (Triglycerides). 9007-73-2 (Ferritins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13051539
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moore+Heslin&issn=2072-6643&title=Nutrients&atitle=Risk+of+Iron+Overload+in+Obesity+and+Implications+in+Metabolic+Health.&volume=13&issue=5&spage=&epage=&date=2021&doi=10.3390%2Fnu13051539&pmid=34063273&sid=OVID:medline
+
+<844>
+Unique Identifier
+ 34062281
+Title
+ Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet.
+Source
+ Cellular and Molecular Gastroenterology and Hepatology. 12(3):891-920, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ganguly S; Muench GA; Shang L; Rosenthal SB; Rahman G; Wang R; Wang Y; Kwon HC; Diomino AM; Kisseleva T; Soorosh P; Hosseini M; Knight R; Schnabl B; Brenner DA; Dhar D
+Authors Full Name
+ Ganguly, Souradipta; Muench, German Aleman; Shang, Linshan; Rosenthal, Sara Brin; Rahman, Gibraan; Wang, Ruoyu; Wang, Yanhan; Kwon, Hyeok Choon; Diomino, Anthony M; Kisseleva, Tatiana; Soorosh, Pejman; Hosseini, Mojgan; Knight, Rob; Schnabl, Bernd; Brenner, David A; Dhar, Debanjan.
+Institution
+ Ganguly, Souradipta. Department of Medicine, University of California San Diego, La Jolla, California.
+ Muench, German Aleman. Janssen Research and Development, San Diego, California.
+ Shang, Linshan. Department of Medicine, University of California San Diego, La Jolla, California.
+ Rosenthal, Sara Brin. Department of Medicine, University of California San Diego, La Jolla, California; Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, California.
+ Rahman, Gibraan. Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, California.
+ Wang, Ruoyu. Department of Medicine, University of California San Diego, La Jolla, California.
+ Wang, Yanhan. Department of Medicine, University of California San Diego, La Jolla, California.
+ Kwon, Hyeok Choon. Department of Gastroenterology and Hepatology, National Medical Center, Jung-Gu, Seoul, South Korea.
+ Diomino, Anthony M. Department of Medicine, University of California San Diego, La Jolla, California.
+ Kisseleva, Tatiana. Department of Surgery, University of California San Diego, La Jolla, California.
+ Soorosh, Pejman. Janssen Research and Development, San Diego, California.
+ Hosseini, Mojgan. Department of Pathology, University of California San Diego, La Jolla, California.
+ Knight, Rob. Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, California; Center for Microbiome Innovation, University of California San Diego, La Jolla, California; Department of Pediatrics, University of California San Diego, La Jolla, California.
+ Schnabl, Bernd. Department of Medicine, University of California San Diego, La Jolla, California.
+ Brenner, David A. Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: dbrenner@health.ucsd.edu.
+ Dhar, Debanjan. Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: ddhar@health.ucsd.edu.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Carcinoma, Hepatocellular/et [Etiology]
+ Carcinoma, Hepatocellular/me [Metabolism]
+ Carcinoma, Hepatocellular/pa [Pathology]
+ Cell Cycle Proteins/df [Deficiency]
+ *Diet, Western/ae [Adverse Effects]
+ Disease Models, Animal
+ *Disease Susceptibility
+ Dyslipidemias/co [Complications]
+ Dyslipidemias/et [Etiology]
+ Gene Expression Profiling
+ *Hyperphagia/co [Complications]
+ Immunohistochemistry
+ Insulin Resistance
+ Liver Cirrhosis/co [Complications]
+ Liver Cirrhosis/et [Etiology]
+ Liver Cirrhosis/pa [Pathology]
+ *Liver Neoplasms/et [Etiology]
+ Liver Neoplasms/me [Metabolism]
+ Liver Neoplasms/pa [Pathology]
+ Mice
+ Mice, Knockout
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/co [Complications]
+ Obesity/et [Etiology]
+Keyword Heading
+ Gut Inflammation
+ Hepatocellular Carcinoma
+ Liver Inflammation
+ NASH Regression
+ Nonalcoholic Steatohepatitis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: How benign liver steatosis progresses to nonalcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma (HCC) remains elusive. NASH progression entails diverse pathogenic mechanisms and relies on complex cross-talk between multiple tissues such as the gut, adipose tissues, liver, and the brain. Using a hyperphagic mouse fed with a Western diet (WD), we aimed to elucidate the cross-talk and kinetics of hepatic and extrahepatic alterations during NASH-HCC progression, as well as regression.
+
+ METHODS: Hyperphagic mice lacking a functional Alms1 gene (Foz/Foz) and wild-type littermates were fed WD or standard chow for 12 weeks for NASH/fibrosis and for 24 weeks for HCC development. NASH regression was modeled by switching back to normal chow after NASH development.
+
+ RESULTS: Foz+WD mice were steatotic within 1 to 2 weeks, developed NASH by 4 weeks, and grade 3 fibrosis by 12 weeks, accompanied by chronic kidney injury. Foz+WD mice that continued on WD progressed to cirrhosis and HCC within 24 weeks and had reduced survival as a result of cardiac dysfunction. However, NASH mice that were switched to normal chow showed NASH regression, improved survival, and did not develop HCC. Transcriptomic and histologic analyses of Foz/Foz NASH liver showed strong concordance with human NASH. NASH was preceded by an early disruption of gut barrier, microbial dysbiosis, lipopolysaccharide leakage, and intestinal inflammation. This led to acute-phase liver inflammation in Foz+WD mice, characterized by neutrophil infiltration and increased levels of several chemokines/cytokines. The liver cytokine/chemokine profile evolved as NASH progressed, with subsequent predominance by monocyte recruitment.
+
+ CONCLUSIONS: The Foz+WD model closely mimics the pathobiology and gene signature of human NASH with fibrosis and subsequent HCC. Foz+WD mice provide a robust and relevant preclinical model of NASH, NASH-associated HCC, chronic kidney injury, and heart failure. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Alms1 protein, mouse). 0 (Biomarkers). 0 (Cell Cycle Proteins).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.jcmgh.2021.05.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ganguly&issn=2352-345X&title=Cellular+and+Molecular+Gastroenterology+and+Hepatology&atitle=Nonalcoholic+Steatohepatitis+and+HCC+in+a+Hyperphagic+Mouse+Accelerated+by+Western+Diet.&volume=12&issue=3&spage=891&epage=920&date=2021&doi=10.1016%2Fj.jcmgh.2021.05.010&pmid=34062281&sid=OVID:medline
+
+<845>
+Unique Identifier
+ 34054734
+Title
+ Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.
+Source
+ Frontiers in Endocrinology. 12:674704, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tanday N; English A; Lafferty RA; Flatt PR; Irwin N
+Authors Full Name
+ Tanday, Neil; English, Andrew; Lafferty, Ryan A; Flatt, Peter R; Irwin, Nigel.
+Institution
+ Tanday, Neil. Diabetes Research Group, School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom.
+ English, Andrew. Diabetes Research Group, School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom.
+ Lafferty, Ryan A. Diabetes Research Group, School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom.
+ Flatt, Peter R. Diabetes Research Group, School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom.
+ Irwin, Nigel. Diabetes Research Group, School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Weight
+ *Diabetes Mellitus, Experimental/dt [Drug Therapy]
+ Diabetes Mellitus, Experimental/me [Metabolism]
+ Diabetes Mellitus, Experimental/pa [Pathology]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Diet, High-Fat
+ *Exenatide/pd [Pharmacology]
+ Glucagon-Like Peptide 1/ge [Genetics]
+ *Glucagon-Like Peptide 1/me [Metabolism]
+ Hypoglycemic Agents/pd [Pharmacology]
+ Insulin Secretion
+ Insulin-Secreting Cells/de [Drug Effects]
+ Insulin-Secreting Cells/me [Metabolism]
+ Insulin-Secreting Cells/pa [Pathology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ *Obesity/pp [Physiopathology]
+ *Peptide Fragments/pd [Pharmacology]
+ Receptors, Cholecystokinin/ge [Genetics]
+ *Receptors, Cholecystokinin/me [Metabolism]
+ Up-Regulation
+Keyword Heading
+ CCK-8
+ GLP-1
+ diabetes
+ exendin-4
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Combined activation of GLP-1 and CCK1 receptors has potential to synergistically augment the appetite-suppressive and glucose homeostatic actions of the individual parent peptides. In the current study, pancreatic beta-cell benefits of combined GLP-1 and CCK1 receptor upregulation were established, before characterising bioactivity and antidiabetic efficacy of an acylated dual-acting GLP-1/CCK hybrid peptide, namely [Lys12Pal]Ex-4/CCK. Both exendin-4 and CCK exhibited (p<0.001) proliferative and anti-apoptotic effects in BRIN BD11 beta-cells. Proliferative benefits were significantly (p<0.01) augmented by combined peptide treatment when compared to either parent peptide alone. These effects were linked to increases (p<0.001) in GLUT2 and glucokinase beta-cell gene expression, with decreased (p<0.05-p<0.001) expression of NFkappaB and BAX. [Lys12Pal]Ex-4/CCK exhibited prominent insulinotropic actions in vitro, coupled with beneficial (p<0.001) satiety and glucose homeostatic effects in the mice, with bioactivity evident 24 h after administration. Following twice daily injection of [Lys12Pal]Ex-4/CCK for 28 days in diabetic high fat fed (HFF) mice with streptozotocin (STZ)-induced compromised beta-cells, there were clear reductions (p<0.05-p<0.001) in energy intake and body weight. Circulating glucose was returned to lean control concentrations, with associated increases (p<0.001) in plasma and pancreatic insulin levels. Glucose tolerance and insulin secretory responsiveness were significantly (p<0.05-p<0.001) improved by hybrid peptide therapy. In keeping with this, evaluation of pancreatic histology revealed restoration of normal islet alpha- to beta-cell ratios and reduction (p<0.01) in centralised islet glucagon staining. Improvements in pancreatic islet morphology were associated with increased (p<0.05) proliferation and reduced (p<0.001) apoptosis of beta-cells. Together, these data highlight the effectiveness of sustained dual GLP-1 and CCK1 receptor activation by [Lys12Pal]Ex-4/CCK for the treatment of obesity-related diabetes. Copyright © 2021 Tanday, English, Lafferty, Flatt and Irwin.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hypoglycemic Agents). 0 (Peptide Fragments). 0 (Receptors, Cholecystokinin). 89750-14-1 (Glucagon-Like Peptide 1). 9P1872D4OL (Exenatide).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.674704
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tanday&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Benefits+of+Sustained+Upregulated+Unimolecular+GLP-1+and+CCK+Receptor+Signalling+in+Obesity-Diabetes.&volume=12&issue=&spage=674704&epage=&date=2021&doi=10.3389%2Ffendo.2021.674704&pmid=34054734&sid=OVID:medline
+
+<846>
+Unique Identifier
+ 34054728
+Title
+ Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study.
+Source
+ Frontiers in Endocrinology. 12:657856, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang Q; Ma X; Xing J; Shi H; Yang R; Jiao Y; Chen S; Wu S; Zhang S; Sun X
+Authors Full Name
+ Zhang, Qian; Ma, Xiaoqian; Xing, Jie; Shi, Haiyun; Yang, Runkuan; Jiao, Yue; Chen, Shuohua; Wu, Shouling; Zhang, Shutian; Sun, Xiujing.
+Institution
+ Zhang, Qian. Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
+ Zhang, Qian. Clinical Epidemiology and EBM Unit, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
+ Ma, Xiaoqian. Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
+ Xing, Jie. Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
+ Shi, Haiyun. Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
+ Yang, Runkuan. Department of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
+ Jiao, Yue. Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
+ Chen, Shuohua. Department of Cardiology, Kailuan General Hospital, Tangshan, China.
+ Wu, Shouling. Department of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
+ Zhang, Shutian. Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
+ Sun, Xiujing. Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ China/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Risk Factors
+ *Uric Acid/bl [Blood]
+Keyword Heading
+ body mass index
+ mediation analysis
+ metabolic syndrome
+ nonalcoholic fatty liver disease
+ obesity
+ serum uric acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.
+
+ Patients and methods: This study enrolled 16,839 participants with no history of alcohol consumption and no fatty liver disease in 2010. All participants completed a survey which included health and lifestyle questionnaires, and underwent physical examination, ultrasonography, and laboratory examinations of blood samples. After the four-year follow up, 5,104 (30.31%) participants were diagnosed with NAFLD. The associations between SUA, BMI or obesity, and incident NAFLD were assessed by multivariate linear regression, logistic regression analysis, and mediation analysis, respectively.
+
+ Results: By adjusting demographic and serum characteristics, linear correlation coefficients between obesity and SUA were 20.26 [95% confidence interval (CI)]: 15.74, 24.77), 13.31 (95% CI: 6.63, 19.99) and 22.21 (95% CI: 16.41, 28.02) in the total population, and in the female and male groups, respectively. The odds ratios were 2.49 (95% CI: 1.61, 3.87) in the total population, 5.71 (95% CI: 2.25, 14.45) in the female group and 1.99 (95% CI: 1.15, 3.45) in the male group for the correlation between obesity and incident NAFLD. The mediation analysis showed that SUA contributed to 10.03%, 0.58%, and 12.54% of obesity-related NAFLD development in the total population, females and males, respectively.
+
+ Conclusion: The findings showed mediation linkages of both obesity and SUA with the incident NAFLD. The role of SUA as a mediator constitutes clinical significance that should be recognized and considered. Copyright © 2021 Zhang, Ma, Xing, Shi, Yang, Jiao, Chen, Wu, Zhang and Sun.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.657856
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Serum+Uric+Acid+Is+a+Mediator+of+the+Association+Between+Obesity+and+Incident+Nonalcoholic+Fatty+Liver+Disease%3A+A+Prospective+Cohort+Study.&volume=12&issue=&spage=657856&epage=&date=2021&doi=10.3389%2Ffendo.2021.657856&pmid=34054728&sid=OVID:medline
+
+<847>
+Unique Identifier
+ 34052657
+Title
+ Divergent dynamics in systemic and tissue-specific metabolic and inflammatory responses during weight loss in subjects with obesity.
+Source
+ Cytokine. 144:155587, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Van de Velde F; Ouwens DM; Batens AH; Van Nieuwenhove Y; Lapauw B
+Authors Full Name
+ Van de Velde, Frederique; Ouwens, D Margriet; Batens, Arsene-Helene; Van Nieuwenhove, Yves; Lapauw, Bruno.
+Institution
+ Van de Velde, Frederique. Department of Endocrinology, Ghent University Hospital, Ghent, Belgium. Electronic address: frederique.vandevelde@ugent.be.
+ Ouwens, D Margriet. Department of Endocrinology, Ghent University Hospital, Ghent, Belgium; Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Duesseldorf, Germany; German Center for Diabetes Research (DZD), Muenchen-Neuherberg, Germany.
+ Batens, Arsene-Helene. Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
+ Van Nieuwenhove, Yves. Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium.
+ Lapauw, Bruno. Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
+MeSH Subject Headings
+ Abdominal Fat/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Female
+ Humans
+ *Inflammation/me [Metabolism]
+ Insulin/me [Metabolism]
+ Male
+ Middle Aged
+ Muscle, Skeletal/me [Metabolism]
+ *Obesity/me [Metabolism]
+ Prospective Studies
+ Subcutaneous Fat/me [Metabolism]
+ *Weight Loss/ph [Physiology]
+Keyword Heading
+ Adipokines
+ Inflammation
+ Insulin resistance
+ Myokines
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Dysfunction of adipose and muscle tissue associates with obesity-related co-morbidities such as insulin resistance (IR) and inflammation. This study investigates changes in systemic and tissue-specific markers of IR and inflammation after gastric bypass surgery (GBS) in subjects with obesity.
+
+ METHODS: Prospective study, twenty subjects with obesity (50 +/- 10 years, 14 men). Prior to, and six months and one year after GBS, subcutaneous abdominal adipose tissue (SAT), skeletal muscle and fasting serum samples were collected. Serum levels of C-reactive protein (CRP), glucose and insulin were determined using standard laboratory assays and serum IL-6, IL-10 and TNF-alpha levels were determined using ELISA. Tissue mRNA expression of inflammation and insulin/glucose metabolism markers were analyzed using qPCR.
+
+ RESULTS: After GBS, HOMA-IR, CRP and IL-6 serum levels decreased. In SAT, expression of bone morphogenetic protein 4 (BMP4), IL-6, IL-10 and MCP1 decreased and GLUT4 increased (all p < 0.05). In muscle, expression of BMP4, GLUT4 and IL-6 decreased and of MCP1 and IRS-1 increased (all p < 0.05).
+
+ CONCLUSION: Systemic improvements in inflammation and IR after GBS are only partially mirrored by corresponding changes in adipokine and myokine expression patterns. As changes in expression of other markers of inflammation and insulin/glucose metabolism appear less consistent and even divergent between tissues, the inflammatory and IR status at systemic level cannot be extrapolated to the situation in metabolically active tissues. Copyright © 2021 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.cyto.2021.155587
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Van+de+Velde&issn=1043-4666&title=Cytokine&atitle=Divergent+dynamics+in+systemic+and+tissue-specific+metabolic+and+inflammatory+responses+during+weight+loss+in+subjects+with+obesity.&volume=144&issue=&spage=155587&epage=&date=2021&doi=10.1016%2Fj.cyto.2021.155587&pmid=34052657&sid=OVID:medline
+
+<848>
+Unique Identifier
+ 34043632
+Title
+ Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.
+Source
+ PLoS ONE [Electronic Resource]. 16(5):e0240764, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bihlmeyer NA; Kwee LC; Clish CB; Deik AA; Gerszten RE; Pagidipati NJ; Laferrere B; Svetkey LP; Newgard CB; Kraus WE; Shah SH
+Author NameID
+ Bihlmeyer, Nathan A; ORCID: https://orcid.org/0000-0002-4415-7419
+ Clish, Clary B; ORCID: https://orcid.org/0000-0001-8259-9245
+ Deik, Amy Anderson; ORCID: https://orcid.org/0000-0002-9687-0953
+Authors Full Name
+ Bihlmeyer, Nathan A; Kwee, Lydia Coulter; Clish, Clary B; Deik, Amy Anderson; Gerszten, Robert E; Pagidipati, Neha J; Laferrere, Blandine; Svetkey, Laura P; Newgard, Christopher B; Kraus, William E; Shah, Svati H.
+Institution
+ Bihlmeyer, Nathan A. Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
+ Kwee, Lydia Coulter. Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
+ Clish, Clary B. Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
+ Deik, Amy Anderson. Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
+ Gerszten, Robert E. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
+ Pagidipati, Neha J. Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States of America.
+ Pagidipati, Neha J. Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.
+ Laferrere, Blandine. Columbia University Irving Medical Center, New York, New York, United States of America.
+ Svetkey, Laura P. Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.
+ Newgard, Christopher B. Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
+ Kraus, William E. Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
+ Shah, Svati H. Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
+ Shah, Svati H. Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States of America.
+ Shah, Svati H. Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Diglycerides/bl [Blood]
+ Female
+ Humans
+ Insulin Resistance/ph [Physiology]
+ Lipid Metabolism/ph [Physiology]
+ Lipids/bl [Blood]
+ Male
+ Mass Spectrometry
+ *Metabolomics
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/me [Metabolism]
+ Obesity/su [Surgery]
+ Obesity/th [Therapy]
+ Triglycerides/bl [Blood]
+ *Weight Loss/ph [Physiology]
+Abstract
+ Obesity is an epidemic internationally. While weight loss interventions are efficacious, they are compounded by heterogeneity with regards to clinically relevant metabolic responses. Thus, we sought to identify metabolic biomarkers that are associated with beneficial metabolic changes to weight loss and which distinguish individuals with obesity who would most benefit from a given type of intervention. Liquid chromatography mass spectrometry-based profiling was used to measure 765 metabolites in baseline plasma from three different weight loss studies: WLM (behavioral intervention, N = 443), STRRIDE-PD (exercise intervention, N = 163), and CBD (surgical cohort, N = 125). The primary outcome was percent change in insulin resistance (as measured by the Homeostatic Model Assessment of Insulin Resistance [%DELTAHOMA-IR]) over the intervention. Overall, 92 individual metabolites were associated with %DELTAHOMA-IR after adjustment for multiple comparisons. Concordantly, the most significant metabolites were triacylglycerols (TAGs; p = 2.3e-5) and diacylglycerols (DAGs; p = 1.6e-4), with higher baseline TAG and DAG levels associated with a greater improvement in insulin resistance with weight loss. In tests of heterogeneity, 50 metabolites changed differently between weight loss interventions; we found amino acids, peptides, and their analogues to be most significant (4.7e-3) in this category. Our results highlight novel metabolic pathways associated with heterogeneity in response to weight loss interventions, and related biomarkers which could be used in future studies of personalized approaches to weight loss interventions.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Diglycerides). 0 (Lipids). 0 (Triglycerides).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1371%2fjournal.pone.0240764
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bihlmeyer&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Metabolomic+profiling+identifies+complex+lipid+species+and+amino+acid+analogues+associated+with+response+to+weight+loss+interventions.&volume=16&issue=5&spage=e0240764&epage=&date=2021&doi=10.1371%2Fjournal.pone.0240764&pmid=34043632&sid=OVID:medline
+
+<849>
+Unique Identifier
+ 34038475
+Title
+ Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity.
+Source
+ PLoS ONE [Electronic Resource]. 16(5):e0252026, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dragon-Durey MA; Chen X; Kirilovsky A; Ben Hamouda N; El Sissy C; Russick J; Charpentier E; Binois Y; Marliot F; Meylan M; Granier C; Pere H; Saldmann A; Rance B; Jannot AS; Baron S; Chebbi M; Fayol A; Josseaume N; Rives-Lange C; Tharaux PL; Cholley B; Diehl JL; Arlet JB; Azizi M; Karras A; Czernichow S; Smadja DM; Hulot JS; Cremer I; Tartour E; Mousseaux E; Pages F
+Author NameID
+ Chen, Xiaoyi; ORCID: https://orcid.org/0000-0002-7378-5158
+ Russick, Jules; ORCID: https://orcid.org/0000-0001-7085-7614
+ Meylan, Maxime; ORCID: https://orcid.org/0000-0002-6175-1954
+ Rives-Lange, Claire; ORCID: https://orcid.org/0000-0001-5393-5406
+ Tharaux, Pierre-Louis; ORCID: https://orcid.org/0000-0002-6062-5905
+ Hulot, Jean-Sebastien; ORCID: https://orcid.org/0000-0001-5463-6117
+ Pages, Franck; ORCID: https://orcid.org/0000-0002-2083-610X
+Authors Full Name
+ Dragon-Durey, Marie-Agnes; Chen, Xiaoyi; Kirilovsky, Amos; Ben Hamouda, Nadine; El Sissy, Carine; Russick, Jules; Charpentier, Etienne; Binois, Yannick; Marliot, Florence; Meylan, Maxime; Granier, Clemence; Pere, Helene; Saldmann, Antonin; Rance, Bastien; Jannot, Anne Sophie; Baron, Stephanie; Chebbi, Mouna; Fayol, Antoine; Josseaume, Nathalie; Rives-Lange, Claire; Tharaux, Pierre-Louis; Cholley, Bernard; Diehl, Jean-Luc; Arlet, Jean-Benoit; Azizi, Michel; Karras, Alexandre; Czernichow, Sebastien; Smadja, David M; Hulot, Jean-Sebastien; Cremer, Isabelle; Tartour, Eric; Mousseaux, Elie; Pages, Franck.
+Institution
+ Dragon-Durey, Marie-Agnes. Laboratory of Immunology.
+ Dragon-Durey, Marie-Agnes. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Dragon-Durey, Marie-Agnes. Universite de Paris, Paris, France.
+ Dragon-Durey, Marie-Agnes. INSERM UMRS 1138, Cordeliers Research Center, Team Inflammation, Complement, and Cancer, Paris, France.
+ Dragon-Durey, Marie-Agnes. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Chen, Xiaoyi. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Chen, Xiaoyi. INSERM UMRS 1138, Cordeliers Research Center, Team Information Sciences to Support Personalized Medicine, Paris, France.
+ Chen, Xiaoyi. Laboratory of Information Sciences to support Personalized Medicine, Paris, France.
+ Kirilovsky, Amos. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Kirilovsky, Amos. INSERM UMRS 1138, Cordeliers Research Center, Team Integrative Cancer Immunology, Paris, France.
+ Ben Hamouda, Nadine. Laboratory of Immunology.
+ Ben Hamouda, Nadine. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ El Sissy, Carine. Laboratory of Immunology.
+ El Sissy, Carine. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ El Sissy, Carine. Universite de Paris, Paris, France.
+ El Sissy, Carine. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ El Sissy, Carine. INSERM UMRS 1138, Cordeliers Research Center, Team Integrative Cancer Immunology, Paris, France.
+ Russick, Jules. INSERM UMRS 1138, Cordeliers Research Center, Team Inflammation, Complement, and Cancer, Paris, France.
+ Russick, Jules. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Charpentier, Etienne. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Charpentier, Etienne. Department of Radiology.
+ Binois, Yannick. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Binois, Yannick. Department of Nephrology.
+ Marliot, Florence. Laboratory of Immunology.
+ Marliot, Florence. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Marliot, Florence. Universite de Paris, Paris, France.
+ Marliot, Florence. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Marliot, Florence. INSERM UMRS 1138, Cordeliers Research Center, Team Integrative Cancer Immunology, Paris, France.
+ Meylan, Maxime. INSERM UMRS 1138, Cordeliers Research Center, Team Inflammation, Complement, and Cancer, Paris, France.
+ Meylan, Maxime. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Granier, Clemence. Laboratory of Immunology.
+ Granier, Clemence. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Granier, Clemence. Universite de Paris, Paris, France.
+ Granier, Clemence. INSERM, Paris Cardiovascular Center / PARCC, UMR 970, Paris, France.
+ Pere, Helene. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Pere, Helene. Universite de Paris, Paris, France.
+ Pere, Helene. INSERM, Paris Cardiovascular Center / PARCC, UMR 970, Paris, France.
+ Pere, Helene. Laboratory of Virology.
+ Saldmann, Antonin. Laboratory of Immunology.
+ Saldmann, Antonin. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Saldmann, Antonin. Universite de Paris, Paris, France.
+ Saldmann, Antonin. INSERM, Paris Cardiovascular Center / PARCC, UMR 970, Paris, France.
+ Rance, Bastien. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Rance, Bastien. Universite de Paris, Paris, France.
+ Rance, Bastien. INSERM UMRS 1138, Cordeliers Research Center, Team Information Sciences to Support Personalized Medicine, Paris, France.
+ Rance, Bastien. Laboratory of Information Sciences to support Personalized Medicine, Paris, France.
+ Rance, Bastien. Biostatistics and Public Health Department.
+ Jannot, Anne Sophie. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Jannot, Anne Sophie. Universite de Paris, Paris, France.
+ Jannot, Anne Sophie. INSERM UMRS 1138, Cordeliers Research Center, Team Information Sciences to Support Personalized Medicine, Paris, France.
+ Jannot, Anne Sophie. Laboratory of Information Sciences to support Personalized Medicine, Paris, France.
+ Jannot, Anne Sophie. Biostatistics and Public Health Department.
+ Baron, Stephanie. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Baron, Stephanie. Universite de Paris, Paris, France.
+ Baron, Stephanie. Department of Physiology.
+ Chebbi, Mouna. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Chebbi, Mouna. Universite de Paris, Paris, France.
+ Chebbi, Mouna. Department of Physiology.
+ Fayol, Antoine. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Fayol, Antoine. Universite de Paris, Paris, France.
+ Fayol, Antoine. Clinic Investigation Center 1418.
+ Josseaume, Nathalie. INSERM UMRS 1138, Cordeliers Research Center, Team Inflammation, Complement, and Cancer, Paris, France.
+ Josseaume, Nathalie. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Rives-Lange, Claire. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Rives-Lange, Claire. Universite de Paris, Paris, France.
+ Rives-Lange, Claire. Department of Nutrition.
+ Tharaux, Pierre-Louis. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Tharaux, Pierre-Louis. Universite de Paris, Paris, France.
+ Tharaux, Pierre-Louis. INSERM, Paris Cardiovascular Center / PARCC, UMR 970, Paris, France.
+ Cholley, Bernard. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Cholley, Bernard. Universite de Paris, Paris, France.
+ Cholley, Bernard. Department of Intensive Medicine, Reanimation.
+ Diehl, Jean-Luc. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Diehl, Jean-Luc. Universite de Paris, Paris, France.
+ Diehl, Jean-Luc. Department of Intensive Medicine, Reanimation.
+ Diehl, Jean-Luc. INSERM UMR-S1140, Team Innovative Therapies in Haemostasis, Paris, France.
+ Arlet, Jean-Benoit. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Arlet, Jean-Benoit. Universite de Paris, Paris, France.
+ Arlet, Jean-Benoit. Department of Internal Medicine.
+ Azizi, Michel. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Azizi, Michel. Universite de Paris, Paris, France.
+ Azizi, Michel. Department of Vascular Medicine.
+ Karras, Alexandre. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Karras, Alexandre. Universite de Paris, Paris, France.
+ Karras, Alexandre. Department of Nephrology.
+ Czernichow, Sebastien. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Czernichow, Sebastien. Universite de Paris, Paris, France.
+ Czernichow, Sebastien. Department of Nutrition.
+ Smadja, David M. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Smadja, David M. Universite de Paris, Paris, France.
+ Smadja, David M. INSERM UMR-S1140, Team Innovative Therapies in Haemostasis, Paris, France.
+ Smadja, David M. Department of Hematology.
+ Hulot, Jean-Sebastien. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Hulot, Jean-Sebastien. Universite de Paris, Paris, France.
+ Hulot, Jean-Sebastien. INSERM, Paris Cardiovascular Center / PARCC, UMR 970, Paris, France.
+ Hulot, Jean-Sebastien. Clinic Investigation Center 1418.
+ Cremer, Isabelle. INSERM UMRS 1138, Cordeliers Research Center, Team Inflammation, Complement, and Cancer, Paris, France.
+ Cremer, Isabelle. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Tartour, Eric. Laboratory of Immunology.
+ Tartour, Eric. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Tartour, Eric. Universite de Paris, Paris, France.
+ Tartour, Eric. INSERM, Paris Cardiovascular Center / PARCC, UMR 970, Paris, France.
+ Mousseaux, Elie. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Mousseaux, Elie. Universite de Paris, Paris, France.
+ Mousseaux, Elie. Department of Radiology.
+ Pages, Franck. Laboratory of Immunology.
+ Pages, Franck. Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
+ Pages, Franck. Universite de Paris, Paris, France.
+ Pages, Franck. Sorbonne Universite, Cordeliers Research Center, Paris, France.
+ Pages, Franck. INSERM UMRS 1138, Cordeliers Research Center, Team Integrative Cancer Immunology, Paris, France.
+MeSH Subject Headings
+ Aged
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ COVID-19/co [Complications]
+ *COVID-19/pa [Pathology]
+ COVID-19/vi [Virology]
+ Chemokines/bl [Blood]
+ Chemokines/me [Metabolism]
+ Cytokines/bl [Blood]
+ *Cytokines/me [Metabolism]
+ Endothelium, Vascular/me [Metabolism]
+ Endothelium, Vascular/pp [Physiopathology]
+ Female
+ Hospitalization/sn [Statistics & Numerical Data]
+ Humans
+ Intensive Care Units
+ Liver/dg [Diagnostic Imaging]
+ *Liver/pp [Physiopathology]
+ Lung/dg [Diagnostic Imaging]
+ *Lung/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity/pa [Pathology]
+ Prospective Studies
+ RNA, Viral/bl [Blood]
+ SARS-CoV-2/ge [Genetics]
+ SARS-CoV-2/ip [Isolation & Purification]
+ Severity of Illness Index
+Abstract
+ To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23). Abnormal BMI (> 25) observed in 72.6% of patients, was associated with a higher rate of intensive care unit hospitalization (p = 0.044). SARS-CoV-2 RNAaemia, peripheral immune cell subsets and cytokines/chemokines were similar among BMI groups. A significant association between inflammatory cytokines and liver, renal, and endothelial dysfunctions was observed only in patients with obesity (BMI > 30). In contrast, early signs of lung damage (ground-glass opacity) correlated with Th1/M1/inflammatory cytokines only in normal weight patients. Later lesions of pulmonary consolidation correlated with BMI but were independent of cytokine levels. Our study reveals distinct physiopathological mechanisms associated with SARS-CoV-2 infection in patients with obesity that may have important clinical implications.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Chemokines). 0 (Cytokines). 0 (RNA, Viral).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1371%2fjournal.pone.0252026
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dragon-Durey&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Differential+association+between+inflammatory+cytokines+and+multiorgan+dysfunction+in+COVID-19+patients+with+obesity.&volume=16&issue=5&spage=e0252026&epage=&date=2021&doi=10.1371%2Fjournal.pone.0252026&pmid=34038475&sid=OVID:medline
+
+<850>
+Unique Identifier
+ 34033591
+Title
+ Central obesity is a contributor to systemic inflammation and monocyte activation in virally suppressed adults with chronic HIV in Kenya.
+Source
+ AIDS. 35(11):1723-1731, 2021 09 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Temu TM; Wagoner J; Masyuko S; O'Connor A; Zifodya JS; Macharia P; Wanjalla CN; Mogaka JN; Chohan B; Omodi VM; Gervassi AL; Oyugi J; Page ST; Farquhar C; Polyak SJ
+Authors Full Name
+ Temu, Tecla M; Wagoner, Jessica; Masyuko, Sarah; O'Connor, Aidan; Zifodya, Jerry S; Macharia, Paul; Wanjalla, Celestine N; Mogaka, Jerusha N; Chohan, Bhavna; Omodi, Victor M; Gervassi, Ana L; Oyugi, Julius; Page, Stephanie T; Farquhar, Carey; Polyak, Stephen J.
+Institution
+ Temu, Tecla M. Department of Global Health, University of Washington, Seattle, Washington, USA.
+ Temu, Tecla M. Institute of Tropical Diseases, University of Nairobi, Nairobi, Kenya.
+ Wagoner, Jessica. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
+ Masyuko, Sarah. Department of Global Health, University of Washington, Seattle, Washington, USA.
+ Masyuko, Sarah. Ministry of Health, Nairobi, Kenya.
+ O'Connor, Aidan. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
+ Zifodya, Jerry S. Department of Medicine, Tulane University, New Orleans, Los Angeles, USA.
+ Macharia, Paul. Consulting in Health Informatics, Nairobi, Kenya.
+ Wanjalla, Celestine N. Departments of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
+ Mogaka, Jerusha N. Department of Global Health, University of Washington, Seattle, Washington, USA.
+ Chohan, Bhavna. Department of Global Health, University of Washington, Seattle, Washington, USA.
+ Omodi, Victor M. AMPATH Partnership, Eldoret, Kenya.
+ Gervassi, Ana L. Seattle Children's Research Institute.
+ Oyugi, Julius. Institute of Tropical Diseases, University of Nairobi, Nairobi, Kenya.
+ Page, Stephanie T. Seattle Children's Research Institute.
+ Farquhar, Carey. Department of Global Health, University of Washington, Seattle, Washington, USA.
+ Farquhar, Carey. Department of Medicine.
+ Farquhar, Carey. Department of Epidemiology, University of Washington, Seattle, Washington, USA.
+ Polyak, Stephen J. Department of Global Health, University of Washington, Seattle, Washington, USA.
+ Polyak, Stephen J. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Cross-Sectional Studies
+ Female
+ HIV Infections/co [Complications]
+ *HIV Infections
+ Humans
+ Inflammation
+ Kenya/ep [Epidemiology]
+ Male
+ Monocytes
+ Obesity/co [Complications]
+ Obesity, Abdominal/co [Complications]
+ Obesity, Abdominal/ep [Epidemiology]
+ *Obesity, Abdominal
+Abstract
+ OBJECTIVES: Heightened systemic inflammation is common in obese individuals and persons with HIV (PWH) and is independently associated with an increased risk of cardiovascular diseases (CVDs). We investigated the combined effect of central obesity, a surrogate measure of visceral fat and HIV on circulating levels of inflammatory cytokines among Kenyan adults.
+
+ DESIGN: A cross-sectional study.
+
+ METHODS: We analysed and compared data from 287 virally suppressed PWH and 277 noninfected Kenyan adults, including biomarkers of gut epithelial dysfunction (intestinal fatty acid binding protein), monocyte activation (soluble CD163 and CD14) and inflammation [interleukin (IL)-1beta, IL-6, TNF-alpha and hsCRP] by HIV/central obesity status (HIV-positive/obese, HIV-negative/obese, HIV-positive/nonobese and HIV-negative/nonobese). Central obesity was defined as waist circumference more than 80 cm for women and more than 94 cm for men. We assessed the association of HIV/obesity status with elevated biomarkers (>75th percentile) using logistic regression.
+
+ RESULTS: Median age for participants was 44 years and 37% were centrally obese. Levels of all biomarkers were higher among the HIV-positive/obese compared with the HIV-negative/nonobese (P < 0.05 for all comparisons). The HIV-positive/obese group had the greatest odds of having elevated inflammatory biomarkers compared with other groups even after adjustment of age, BMI and other conventional CVD risk factors (P < 0.05 for all). Additional adjustment for sCD163 in the multivariate model substantially attenuated the association for HIV-positive/obesity with IL-1beta, IL-6 and TNF-alpha but not hsCRP. The contribution of HIV-positive/obesity to inflammation was independent of the degree of immunosuppression.
+
+ CONCLUSION: Central obesity is prevalent among virally suppressed African PWH and is associated with greater inflammation and monocyte activation independent of other comorbidities and HIV-specific factors. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1097%2fQAD.0000000000002956
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Temu&issn=0269-9370&title=AIDS&atitle=Central+obesity+is+a+contributor+to+systemic+inflammation+and+monocyte+activation+in+virally+suppressed+adults+with+chronic+HIV+in+Kenya.&volume=35&issue=11&spage=1723&epage=1731&date=2021&doi=10.1097%2FQAD.0000000000002956&pmid=34033591&sid=OVID:medline
+
+<851>
+Unique Identifier
+ 34029955
+Title
+ Electroacupuncture facilitates M2 macrophage polarization and its potential role in the regulation of inflammatory response.
+Source
+ Biomedicine & Pharmacotherapy. 140:111655, 2021 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang HF; Chen L; Xie Y; Wang XF; Yang K; Ning Y; He JY; Ding WJ
+Authors Full Name
+ Wang, Huai-Fu; Chen, Li; Xie, Ya; Wang, Xiao-Fang; Yang, Kun; Ning, Ying; He, Jia-Yue; Ding, Wei-Jun.
+Institution
+ Wang, Huai-Fu. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China.
+ Chen, Li. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China; Department of Endocrinology, Meishan Hospital of Traditional Chinese Medicine, 14# Suci Road, Dongpo District, Meishan, Sichuan, China.
+ Xie, Ya. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China.
+ Wang, Xiao-Fang. Department of Nursing, Sichuan Nursing Vocational College, Longdu South Road, Longquanyi District, Chengdu 610100, China.
+ Yang, Kun. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China.
+ Ning, Ying. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China.
+ He, Jia-Yue. Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China.
+ Ding, Wei-Jun. Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China.
+MeSH Subject Headings
+ Acupuncture Points
+ Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pp [Physiopathology]
+ Animals
+ Biomarkers/me [Metabolism]
+ Down-Regulation/ph [Physiology]
+ Electroacupuncture/mt [Methods]
+ Inflammation/me [Metabolism]
+ *Inflammation/pp [Physiopathology]
+ Macrophages/me [Metabolism]
+ *Macrophages/ph [Physiology]
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ RNA, Messenger/me [Metabolism]
+ Spleen/me [Metabolism]
+ Spleen/pp [Physiopathology]
+ Up-Regulation/ph [Physiology]
+Keyword Heading
+ Adipocytokines
+ Adipose tissue
+ Electroacupuncture
+ Macrophage polarization
+ Pro-inflammatory factors
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The underlying mechanism of electroacupuncture (EA) in relieving obesity, anti-inflammation and the interaction with metabolic pathways in obese mice has not been elaborated. The aim of this study was to investigate the regulation of EA on macrophage polarization in obesity tissue of diet-induced obesity mice. Mice were divided in 6 groups: normal control group, model group, EA-7 group, EA-14 group, EA-21 group and EA-28 group. Low-frequency EA was applied at "Tianshu (ST 25)", "Guanyuan (CV 4)", "Zusanli (ST 36)" and "Sanyinjiao (SP 6)" for 10 min. Adipose tissue was assessed with hematoxylin and eosin staining. Adipocytokines and pro-inflammatory factors expression was measured by ELISA. The protein and mRNA levels of macrophage markers were examined by immumohistochemical staining and RT-PCR, respectively. EA treatment was associated with a decrease of adipose tissue and large adipocytes, and an increase of small adipocytes. After EA treatment, the levels of Leptin, Chemerin, TNF-alpha, F4/80, iNOS, and CD11c decreased obviously in adipose tissue, while IL-4, IL-10 and CD206 levels increased significantly. Besides, TNF-alpha in spleen tissue was also downregulated, but IL-4 and IL-10 were upregulated. EA prevents weight gain through modulation inflammatory response and macrophage polarization in obese adipose tissues. Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Messenger).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.biopha.2021.111655
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0753-3322&title=Biomedicine+%26+Pharmacotherapy&atitle=Electroacupuncture+facilitates+M2+macrophage+polarization+and+its+potential+role+in+the+regulation+of+inflammatory+response.&volume=140&issue=&spage=111655&epage=&date=2021&doi=10.1016%2Fj.biopha.2021.111655&pmid=34029955&sid=OVID:medline
+
+<852>
+Unique Identifier
+ 34018016
+Title
+ LMO3 reprograms visceral adipocyte metabolism during obesity.
+Source
+ Journal of Molecular Medicine. 99(8):1151-1171, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wagner G; Fenzl A; Lindroos-Christensen J; Einwallner E; Husa J; Witzeneder N; Rauscher S; Groger M; Derdak S; Mohr T; Sutterluty H; Klinglmuller F; Wolkerstorfer S; Fondi M; Hoermann G; Cao L; Wagner O; Kiefer FW; Esterbauer H; Bilban M
+Author NameID
+ Bilban, Martin; ORCID: https://orcid.org/0000-0001-7043-7142
+Authors Full Name
+ Wagner, Gabriel; Fenzl, Anna; Lindroos-Christensen, Josefine; Einwallner, Elisa; Husa, Julia; Witzeneder, Nadine; Rauscher, Sabine; Groger, Marion; Derdak, Sophia; Mohr, Thomas; Sutterluty, Hedwig; Klinglmuller, Florian; Wolkerstorfer, Silviya; Fondi, Martina; Hoermann, Gregor; Cao, Lei; Wagner, Oswald; Kiefer, Florian W; Esterbauer, Harald; Bilban, Martin.
+Institution
+ Wagner, Gabriel. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Fenzl, Anna. Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, 1090, Vienna, Austria.
+ Lindroos-Christensen, Josefine. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Lindroos-Christensen, Josefine. Novo Nordisk, Maaloev, Denmark.
+ Einwallner, Elisa. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Husa, Julia. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Witzeneder, Nadine. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Rauscher, Sabine. Core Facilities, Medical University of Vienna, 1090, Vienna, Austria.
+ Groger, Marion. Core Facilities, Medical University of Vienna, 1090, Vienna, Austria.
+ Derdak, Sophia. Core Facilities, Medical University of Vienna, 1090, Vienna, Austria.
+ Mohr, Thomas. Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria.
+ Sutterluty, Hedwig. Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria.
+ Klinglmuller, Florian. Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, 1090, Vienna, Austria.
+ Klinglmuller, Florian. Austrian Medicines & Medical Devices Agency, 1200, Vienna, Austria.
+ Wolkerstorfer, Silviya. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Wolkerstorfer, Silviya. University of Applied Sciences, FH Campus Wien, 1100, Vienna, Austria.
+ Wolkerstorfer, Silviya. Institute of Cardiovascular Prevention, Ludwig-Maximilians-University, 80336, Munich, Germany.
+ Fondi, Martina. University of Applied Sciences, FH Campus Wien, 1100, Vienna, Austria.
+ Hoermann, Gregor. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Hoermann, Gregor. Central Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Innsbruck, 6020, Innsbruck, Austria.
+ Cao, Lei. Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, 43210, USA.
+ Wagner, Oswald. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Kiefer, Florian W. Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, 1090, Vienna, Austria.
+ Esterbauer, Harald. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria.
+ Bilban, Martin. Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria. martin.bilban@meduniwien.ac.at.
+ Bilban, Martin. Core Facilities, Medical University of Vienna, 1090, Vienna, Austria. martin.bilban@meduniwien.ac.at.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ *Adaptor Proteins, Signal Transducing/ge [Genetics]
+ Adaptor Proteins, Signal Transducing/me [Metabolism]
+ *Adipocytes/me [Metabolism]
+ Animals
+ Biomarkers
+ Disease Models, Animal
+ Disease Susceptibility
+ *Energy Metabolism
+ Gene Expression
+ Gene Expression Profiling
+ Gene Expression Regulation
+ Glucose/me [Metabolism]
+ Glucose Transporter Type 4/ge [Genetics]
+ Glucose Transporter Type 4/me [Metabolism]
+ Humans
+ Insulin/me [Metabolism]
+ Intra-Abdominal Fat/cy [Cytology]
+ *Intra-Abdominal Fat/me [Metabolism]
+ *LIM Domain Proteins/ge [Genetics]
+ LIM Domain Proteins/me [Metabolism]
+ Mice
+ Mitochondria/ge [Genetics]
+ Mitochondria/me [Metabolism]
+ Models, Biological
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Oxidation-Reduction
+ Oxidative Phosphorylation
+ PPAR gamma/me [Metabolism]
+ Protein Binding
+Keyword Heading
+ LMO3
+ Obesity
+ Visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and body fat distribution are important risk factors for the development of type 2 diabetes and metabolic syndrome. Evidence has accumulated that this risk is related to intrinsic differences in behavior of adipocytes in different fat depots. We recently identified LIM domain only 3 (LMO3) in human mature visceral adipocytes; however, its function in these cells is currently unknown. The aim of this study was to determine the potential involvement of LMO3-dependent pathways in the modulation of key functions of mature adipocytes during obesity. Based on a recently engineered hybrid rAAV serotype Rec2 shown to efficiently transduce both brown adipose tissue (BAT) and white adipose tissue (WAT), we delivered YFP or Lmo3 to epididymal WAT (eWAT) of C57Bl6/J mice on a high-fat diet (HFD). The effects of eWAT transduction on metabolic parameters were evaluated 10 weeks later. To further define the role of LMO3 in insulin-stimulated glucose uptake, insulin signaling, adipocyte bioenergetics, as well as endocrine function, experiments were conducted in 3T3-L1 adipocytes and newly differentiated human primary mature adipocytes, engineered for transient gain or loss of LMO3 expression, respectively. AAV transduction of eWAT results in strong and stable Lmo3 expression specifically in the adipocyte fraction over a course of 10 weeks with HFD feeding. LMO3 expression in eWAT significantly improved insulin sensitivity and healthy visceral adipose tissue expansion in diet-induced obesity, paralleled by increased serum adiponectin. In vitro, LMO3 expression in 3T3-L1 adipocytes increased PPARgamma transcriptional activity, insulin-stimulated GLUT4 translocation and glucose uptake, as well as mitochondrial oxidative capacity in addition to fatty acid oxidation. Mechanistically, LMO3 induced the PPARgamma coregulator Ncoa1, which was required for LMO3 to enhance glucose uptake and mitochondrial oxidative gene expression. In human mature adipocytes, LMO3 overexpression promoted, while silencing of LMO3 suppressed mitochondrial oxidative capacity. LMO3 expression in visceral adipose tissue regulates multiple genes that preserve adipose tissue functionality during obesity, such as glucose metabolism, insulin sensitivity, mitochondrial function, and adiponectin secretion. Together with increased PPARgamma activity and Ncoa1 expression, these gene expression changes promote insulin-induced GLUT4 translocation, glucose uptake in addition to increased mitochondrial oxidative capacity, limiting HFD-induced adipose dysfunction. These data add LMO3 as a novel regulator improving visceral adipose tissue function during obesity. KEY MESSAGES: LMO3 increases beneficial visceral adipose tissue expansion and insulin sensitivity in vivo. LMO3 increases glucose uptake and oxidative mitochondrial activity in adipocytes. LMO3 increases nuclear coactivator 1 (Ncoa1). LMO3-enhanced glucose uptake and mitochondrial gene expression requires Ncoa1. Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Adaptor Proteins, Signal Transducing). 0 (Biomarkers). 0 (Glucose Transporter Type 4). 0 (Insulin). 0 (LIM Domain Proteins). 0 (LMO3 protein, human). 0 (PPAR gamma). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs00109-021-02089-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wagner&issn=0946-2716&title=Journal+of+Molecular+Medicine&atitle=LMO3+reprograms+visceral+adipocyte+metabolism+during+obesity.&volume=99&issue=8&spage=1151&epage=1171&date=2021&doi=10.1007%2Fs00109-021-02089-9&pmid=34018016&sid=OVID:medline
+
+<853>
+Unique Identifier
+ 34017061
+Title
+ Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity.
+Source
+ Experimental & Molecular Medicine. 53(5):917-932, 2021 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Choi WI; Yoon JH; Choi SH; Jeon BN; Kim H; Hur MW
+Author NameID
+ Kim, Hail; ORCID: http://orcid.org/0000-0002-6652-1349
+ Hur, Man-Wook; ORCID: http://orcid.org/0000-0002-3416-1334
+Authors Full Name
+ Choi, Won-Il; Yoon, Jae-Hyun; Choi, Seo-Hyun; Jeon, Bu-Nam; Kim, Hail; Hur, Man-Wook.
+Institution
+ Choi, Won-Il. Brain Korea FOUR Project for Medical Science, Department of Biochemistry & Molecular Biology, Yonsei University School of Medicine, 50-1 Yonsei-Ro, SeoDaeMoon-Ku, Seoul, 03722, Korea.
+ Choi, Won-Il. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, DaeJeon, 34141, Korea.
+ Yoon, Jae-Hyun. Brain Korea FOUR Project for Medical Science, Department of Biochemistry & Molecular Biology, Yonsei University School of Medicine, 50-1 Yonsei-Ro, SeoDaeMoon-Ku, Seoul, 03722, Korea.
+ Choi, Seo-Hyun. Brain Korea FOUR Project for Medical Science, Department of Biochemistry & Molecular Biology, Yonsei University School of Medicine, 50-1 Yonsei-Ro, SeoDaeMoon-Ku, Seoul, 03722, Korea.
+ Jeon, Bu-Nam. Brain Korea FOUR Project for Medical Science, Department of Biochemistry & Molecular Biology, Yonsei University School of Medicine, 50-1 Yonsei-Ro, SeoDaeMoon-Ku, Seoul, 03722, Korea.
+ Kim, Hail. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, DaeJeon, 34141, Korea.
+ Kim, Hail. KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea.
+ Hur, Man-Wook. Brain Korea FOUR Project for Medical Science, Department of Biochemistry & Molecular Biology, Yonsei University School of Medicine, 50-1 Yonsei-Ro, SeoDaeMoon-Ku, Seoul, 03722, Korea. mwhur2@yuhs.ac.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ Adipocytes/cy [Cytology]
+ Adipocytes/me [Metabolism]
+ *Aging/ge [Genetics]
+ *Aging/me [Metabolism]
+ Animals
+ Biomarkers
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ Disease Models, Animal
+ Disease Susceptibility
+ Gene Expression Regulation
+ Gene Expression Regulation, Enzymologic
+ *Intracellular Signaling Peptides and Proteins/ge [Genetics]
+ Intracellular Signaling Peptides and Proteins/me [Metabolism]
+ Lipid Metabolism
+ Mice
+ Mice, Knockout
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Oncogene Proteins/ge [Genetics]
+ Oncogene Proteins/me [Metabolism]
+ Protein Binding
+ Response Elements
+ *Sirtuin 1/ge [Genetics]
+ Sirtuin 1/me [Metabolism]
+ Transcription Factors/me [Metabolism]
+ Tumor Suppressor Protein p53/ge [Genetics]
+ Tumor Suppressor Protein p53/me [Metabolism]
+Abstract
+ Zbtb7c is a proto-oncoprotein that controls the cell cycle and glucose, glutamate, and lipid metabolism. Zbtb7c expression is increased in the liver and white adipose tissues of aging or high-fat diet-fed mice. Knockout or knockdown of Zbtb7c gene expression inhibits the adipocyte differentiation of 3T3-L1 cells and decreases adipose tissue mass in aging mice. We found that Zbtb7c was a potent transcriptional repressor of SIRT1 and that SIRT1 was derepressed in various tissues of Zbtb7c-KO mice. Mechanistically, Zbtb7c interacted with p53 and bound to the proximal promoter p53RE1 and p53RE2 to repress the SIRT1 gene, in which p53RE2 was particularly critical. Zbtb7c induced p53 to interact with the corepressor mSin3A-HADC1 complex at p53RE. By repressing the SIRT1 gene, Zbtb7c increased the acetylation of Pgc-1alpha and Ppargamma, which resulted in repression or activation of Pgc-1alpha or Ppargamma target genes involved in lipid metabolism. Our study provides a molecular target that can overexpress SIRT1 protein in the liver, pancreas, and adipose tissues, which can be beneficial in the treatment of diabetes, obesity, longevity, etc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Intracellular Signaling Peptides and Proteins). 0 (Oncogene Proteins). 0 (Transcription Factors). 0 (Trp53 protein, mouse). 0 (Tumor Suppressor Protein p53). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs12276-021-00628-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Choi&issn=1226-3613&title=Experimental+%26+Molecular+Medicine&atitle=Proto-oncoprotein+Zbtb7c+and+SIRT1+repression%3A+implications+in+high-fat+diet-induced+and+age-dependent+obesity.&volume=53&issue=5&spage=917&epage=932&date=2021&doi=10.1038%2Fs12276-021-00628-5&pmid=34017061&sid=OVID:medline
+
+<854>
+Unique Identifier
+ 34015361
+Title
+ Rapamycin delays allograft rejection in obese graft recipients through induction of myeloid-derived suppressor cells.
+Source
+ Immunology Letters. 236:1-11, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Deisler A; Della Penna A; van Geffen C; Gonzalez-Menendez I; Quintanilla-Martinez L; Gunther A; Schneiderhan-Marra N; Hartl D; Nurnberg B; Konigsrainer A; Kolahian S; Quante M
+Authors Full Name
+ Deisler, Astrid; Della Penna, Andrea; van Geffen, Chiel; Gonzalez-Menendez, Irene; Quintanilla-Martinez, Leticia; Gunther, Anna; Schneiderhan-Marra, Nicole; Hartl, Dominik; Nurnberg, Bernd; Konigsrainer, Alfred; Kolahian, Saeed; Quante, Markus.
+Institution
+ Deisler, Astrid. Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Tubingen, Germany; Department of Experimental and Clinical Pharmacology and Pharmacogenomics, University Hospital Tubingen, Tubingen, Germany.
+ Della Penna, Andrea. Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Tubingen, Germany.
+ van Geffen, Chiel. Department of Experimental and Clinical Pharmacology and Pharmacogenomics, University Hospital Tubingen, Tubingen, Germany.
+ Gonzalez-Menendez, Irene. Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tubingen, University Hospital Tubingen, Tubingen, Germany.
+ Quintanilla-Martinez, Leticia. Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tubingen, University Hospital Tubingen, Tubingen, Germany.
+ Gunther, Anna. NMI Natural and Medical Sciences Institute at the University of Tubingen, Reutlingen, Germany.
+ Schneiderhan-Marra, Nicole. NMI Natural and Medical Sciences Institute at the University of Tubingen, Reutlingen, Germany.
+ Hartl, Dominik. Department of Pediatrics I, University Hospital Tubingen, Tubingen, Germany; Novartis Institutes for BioMedical Research, Basel, Switzerland.
+ Nurnberg, Bernd. Department of Pharmacology, Experimental Therapy & Toxicology and Interfaculty Center of Pharmacogenomics & Drug Research (IZePhA), University Hospitals and Clinics, Eberhard-Karls University Tubingen, Germany.
+ Konigsrainer, Alfred. Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Tubingen, Germany.
+ Kolahian, Saeed. Department of Experimental and Clinical Pharmacology and Pharmacogenomics, University Hospital Tubingen, Tubingen, Germany; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany; Universities of Giessen and Marburg Lung Center, German Center for Lung Research (DZL), Marburg, Germany. Electronic address: saeed.kolahian@med.uni-tuebingen.de.
+ Quante, Markus. Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Tubingen, Germany. Electronic address: markus.quante@med.uni-tuebingen.de.
+MeSH Subject Headings
+ Allografts
+ Animals
+ Biomarkers
+ Cytokines/me [Metabolism]
+ Disease Models, Animal
+ Disease Susceptibility
+ Gene Expression
+ *Graft Rejection/dt [Drug Therapy]
+ *Graft Rejection/im [Immunology]
+ Immune Tolerance/de [Drug Effects]
+ Immunomodulation
+ Immunophenotyping
+ *Immunosuppressive Agents/pd [Pharmacology]
+ Mice
+ *Myeloid-Derived Suppressor Cells/im [Immunology]
+ Myeloid-Derived Suppressor Cells/me [Metabolism]
+ *Obesity/im [Immunology]
+ Obesity/me [Metabolism]
+ *Sirolimus/pd [Pharmacology]
+ Skin Transplantation
+ T-Lymphocyte Subsets/im [Immunology]
+ T-Lymphocyte Subsets/me [Metabolism]
+ Transplant Recipients
+Keyword Heading
+ MDSCs
+ Obesity
+ Rapamycin
+ T cells
+ Transplantation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity has become a relevant problem in transplantation medicine with steadily increasing numbers of obese graft recipients. However, the effect of immunomodulatory drugs on transplant-related outcomes among obese patients are unknown. Therefore, we evaluated the impact of rapamycin on allograft rejection and alloimmune response in a murine model of diet-induced obesity and fully-mismatched skin transplantation. Rapamycin significantly delayed allograft rejection in obese recipient mice compared to treated lean mice (14.5 days vs. 10.7 days, p = 0.005). Treatment with rapamycin increased frequencies of monocytic myeloid-derived suppressor cells (M-MDSCs), augmented the immunosuppressive activity of M-MDSCs on T cells through indoleamine 2,3-dioxygenase pathway and shifted CD4+T cells towards regulatory T cells in obese graft recipients. In summary, our results demonstrate that rapamycin delays allograft rejection in obese graft recipients by enhancing suppressive immune cell function and shifting immune cell subsets towards anti-inflammatory conditions. Copyright © 2021 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Immunosuppressive Agents). W36ZG6FT64 (Sirolimus).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.imlet.2021.05.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Deisler&issn=0165-2478&title=Immunology+Letters&atitle=Rapamycin+delays+allograft+rejection+in+obese+graft+recipients+through+induction+of+myeloid-derived+suppressor+cells.&volume=236&issue=&spage=1&epage=11&date=2021&doi=10.1016%2Fj.imlet.2021.05.003&pmid=34015361&sid=OVID:medline
+
+<855>
+Unique Identifier
+ 34011124
+Title
+ Alterations of bone markers in obese patients with type 2 diabetes after bariatric surgery: A meta-analysis and systemic review of randomized controlled trials and cohorts.
+Source
+ Medicine. 100(20):e26061, 2021 May 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang TW; Chen JY; Wu YL; Kao CC; Yeh SC; Lin YC
+Author NameID
+ Lin, Yen-Chung; ORCID: https://orcid.org/0000-0002-8981-8671
+Authors Full Name
+ Huang, Tzu-Wen; Chen, Jing-Yi; Wu, Yueh-Lin; Kao, Chih-Chin; Yeh, Shu-Ching; Lin, Yen-Chung.
+Institution
+ Huang, Tzu-Wen. Department of Medical Education, Taichung Veterans General Hospital, Taichung.
+ Chen, Jing-Yi. Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital.
+ Chen, Jing-Yi. TMU-Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan.
+ Wu, Yueh-Lin. Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital.
+ Kao, Chih-Chin. Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital.
+ Kao, Chih-Chin. Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine.
+ Kao, Chih-Chin. TMU-Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan.
+ Yeh, Shu-Ching. Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital.
+ Yeh, Shu-Ching. TMU-Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan.
+ Lin, Yen-Chung. Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital.
+ Lin, Yen-Chung. Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine.
+ Lin, Yen-Chung. TMU-Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan.
+MeSH Subject Headings
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ Bone Density
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Humans
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/su [Surgery]
+ *Osteoporosis/bl [Blood]
+ Osteoporosis/co [Complications]
+ Osteoporosis/di [Diagnosis]
+Abstract
+ BACKGROUND: The aim of this study is to evaluate the alterations in bone mineral density and other surrogate markers for osteoporosis in obese patients with type 2 diabetes mellitus (T2DM) who received Roux-en-Y gastric bypass (RYGB) versus medical treatment as control.
+
+ METHODS: We searched 4 electronic databases and reference lists of relevant studies for eligible research published before December, 2019. After quality assessment, eligible studies were synthesized for relevant outcomes, including lumbar spine bone mineral density (L-spine BMD) change, total hip BMD change, osteocalcin level, C-terminal telopeptide level, and parathyroid hormone level.
+
+ RESULTS: Three randomized clinical trials and 2 observational studies concerning 307 total obese T2DM patients were included. Follow-up ranged from 12 to 60 months. Patients underwent RYGB surgery were associated with both higher L-spine BMD loss (mean difference: -2.90, 95% CI: -2.99~-2.81, P < .00001) and total hip BMD loss (mean difference: -5.81, 95% CI: -9.22~-2.40, P = .0008). As to biochemical markers of bone metabolism, we found significantly higher osteocalcin level in medical treatment (control) group compared with RYGB group (mean difference: 11.16, 95% CI: 8.57-13.75, P < .00001). However, higher C-terminal telopeptide level and parathyroid hormone level were noted in medical treatment group (control) compared with RYGB group (mean difference: 0.29, 95% CI: 0.11-0.48, P = .002; mean difference: 1.56, 95% CI: 0.84-2.27, P < .0001).
+
+ CONCLUSIONS: RYGB surgery is associated with negative impact on bone metabolism and increase the risk of osteoporosis in obese patients with T2DM. We suggest that clinicians acknowledge the adverse effects of surgery and keep monitoring bone mineral components in post-RYGB populations. Further studies regarding the optimal amount of perioperative and postsurgical supplementation should be evaluated. Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1097%2fMD.0000000000026061
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=0025-7974&title=Medicine&atitle=Alterations+of+bone+markers+in+obese+patients+with+type+2+diabetes+after+bariatric+surgery%3A+A+meta-analysis+and+systemic+review+of+randomized+controlled+trials+and+cohorts.&volume=100&issue=20&spage=e26061&epage=&date=2021&doi=10.1097%2FMD.0000000000026061&pmid=34011124&sid=OVID:medline
+
+<856>
+Unique Identifier
+ 34009040
+Title
+ Biomarkers for assessment of intestinal permeability in clinical practice.
+Source
+ American Journal of Physiology - Gastrointestinal & Liver Physiology. 321(1):G11-G17, 2021 07 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Seethaler B; Basrai M; Neyrinck AM; Nazare JA; Walter J; Delzenne NM; Bischoff SC
+Authors Full Name
+ Seethaler, Benjamin; Basrai, Maryam; Neyrinck, Audrey M; Nazare, Julie-Anne; Walter, Jens; Delzenne, Nathalie M; Bischoff, Stephan C.
+Institution
+ Seethaler, Benjamin. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+ Basrai, Maryam. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+ Neyrinck, Audrey M. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain (UCLouvain), Brussels, Belgium.
+ Nazare, Julie-Anne. Human Nutrition Research Center Rhone-Alpes (CRNH Rhone-Alpes), CarMeN Laboratory, Univ-Lyon, Universite Claude Bernard Lyon1, Lyon, France.
+ Walter, Jens. APC Microbiome Ireland, School of Microbiology and Department of Medicine, University College Cork - National University of Ireland Cork, Cork, Ireland.
+ Delzenne, Nathalie M. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain (UCLouvain), Brussels, Belgium.
+ Bischoff, Stephan C. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ Cross-Sectional Studies
+ Fatty Acid-Binding Proteins/me [Metabolism]
+ Female
+ Gastrointestinal Microbiome/ph [Physiology]
+ *Haptoglobins/me [Metabolism]
+ Humans
+ *Intestinal Mucosa/me [Metabolism]
+ Male
+ Obesity/me [Metabolism]
+ *Permeability
+ Prospective Studies
+ *Protein Precursors/me [Metabolism]
+Keyword Heading
+ LBP
+ gut barrier
+ gut health
+ gut permeability
+ zonulin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Intestinal permeability is an important diagnostic marker, yet its determination by established tests, which measure the urinary excretion of orally administered tracer molecules, is time consuming and can only be performed prospectively. Here, we aim to validate proposed surrogate biomarkers, which allow measuring intestinal permeability more easily. In this cross-sectional study, we included two independent cohorts comprising nonobese (Healthy cohort, n = 51) and individuals with obesity (Obesity cohort, n = 27). The lactulose/mannitol (lac/man) ratio was determined in all individuals as an established marker of intestinal permeability. Furthermore, we measured six potential surrogate biomarkers, being albumin, calprotectin, and zonulin, measured in feces, as well as intestinal fatty acid binding protein (I-FABP), lipopolysaccharide binding protein (LBP) and zonulin, measured in plasma. Correlation analyses and multiple linear regression models were conducted to assess possible associations between the established lac/man ratio and the proposed biomarkers by also evaluating a potential effect of age, body mass index (BMI), and sex. The lac/man ratio correlated with plasma LBP levels in all cohorts consistently and with the amount of fecal zonulin in overweight and obese individuals. Multiple linear regression models showed that the association between the lac/man ratio and plasma LBP was independent of age, BMI, and sex. Fecal zonulin levels were associated with the lac/man ratio as well as BMI, but not age and sex. Our data suggest plasma LBP as a promising biomarker for intestinal permeability in adults and fecal zonulin as a potential biomarker in overweight and obese individuals. NEW & NOTEWORTHY This study shows that biomarkers from blood and fecal samples are associated with the cumbersome established tests of intestinal permeability throughout different cohorts. Therefore, such biomarkers could be used to assess gut barrier function in prospective cohort studies and large-scale clinical trials for which tracer-based tests may not be feasible.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acid-Binding Proteins). 0 (Haptoglobins). 0 (Protein Precursors). 0 (zonulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1152%2fajpgi.00113.2021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Seethaler&issn=0193-1857&title=American+Journal+of+Physiology+-+Gastrointestinal+%26+Liver+Physiology&atitle=Biomarkers+for+assessment+of+intestinal+permeability+in+clinical+practice.&volume=321&issue=1&spage=G11&epage=G17&date=2021&doi=10.1152%2Fajpgi.00113.2021&pmid=34009040&sid=OVID:medline
+
+<857>
+Unique Identifier
+ 34004161
+Title
+ Associations Among Adipose Tissue Immunology, Inflammation, Exosomes and Insulin Sensitivity in People With Obesity and Nonalcoholic Fatty Liver Disease.
+Source
+ Gastroenterology. 161(3):968-981.e12, 2021 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fuchs A; Samovski D; Smith GI; Cifarelli V; Farabi SS; Yoshino J; Pietka T; Chang SW; Ghosh S; Myckatyn TM; Klein S
+Authors Full Name
+ Fuchs, Anja; Samovski, Dmitri; Smith, Gordon I; Cifarelli, Vincenza; Farabi, Sarah S; Yoshino, Jun; Pietka, Terri; Chang, Shin-Wen; Ghosh, Sarbani; Myckatyn, Terence M; Klein, Samuel.
+Institution
+ Fuchs, Anja. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Samovski, Dmitri. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.
+ Smith, Gordon I. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.
+ Cifarelli, Vincenza. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.
+ Farabi, Sarah S. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.
+ Yoshino, Jun. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.
+ Pietka, Terri. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.
+ Chang, Shin-Wen. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Ghosh, Sarbani. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Myckatyn, Terence M. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Klein, Samuel. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri. Electronic address: sklein@wustl.edu.
+MeSH Subject Headings
+ Adult
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Cells, Cultured
+ *Cytokines/bl [Blood]
+ Exosomes/im [Immunology]
+ *Exosomes/me [Metabolism]
+ Female
+ Hepatocytes/me [Metabolism]
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Liver/me [Metabolism]
+ Macrophages/im [Immunology]
+ *Macrophages/me [Metabolism]
+ Male
+ Memory T Cells/im [Immunology]
+ *Memory T Cells/me [Metabolism]
+ Mice
+ Mice, Inbred C57BL
+ Muscle Fibers, Skeletal/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/im [Immunology]
+ Non-alcoholic Fatty Liver Disease/pp [Physiopathology]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/im [Immunology]
+ Obesity/pp [Physiopathology]
+ *Plasminogen Activator Inhibitor 1/bl [Blood]
+ Subcutaneous Fat, Abdominal/im [Immunology]
+ *Subcutaneous Fat, Abdominal/me [Metabolism]
+ Tissue Culture Techniques
+Keyword Heading
+ Cytokines
+ Insulin Resistance
+ Macrophages
+ PAI-1
+ T Cells
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Insulin resistance is a key factor in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). We evaluated the importance of subcutaneous abdominal adipose tissue (SAAT) inflammation and both plasma and SAAT-derived exosomes in regulating insulin sensitivity in people with obesity and NAFLD.
+
+ METHODS: Adipose tissue inflammation (macrophage and T-cell content and expression of proinflammatory cytokines), liver and whole-body insulin sensitivity (assessed using a hyperinsulinemic-euglycemic clamp and glucose tracer infusion), and 24-hour serial plasma cytokine concentrations were evaluated in 3 groups stratified by adiposity and intrahepatic triglyceride (IHTG) content: (1) lean with normal IHTG content (LEAN; N = 14); (2) obese with normal IHTG content (OB-NL; N = 28); and (3) obese with NAFLD (OB-NAFLD; N = 28). The effect of plasma and SAAT-derived exosomes on insulin-stimulated Akt phosphorylation in human skeletal muscle myotubes and mouse primary hepatocytes was assessed in a subset of participants.
+
+ RESULTS: Proinflammatory macrophages, proinflammatory CD4 and CD8 T-cell populations, and gene expression of several cytokines in SAAT were greater in the OB-NAFLD than the OB-NL and LEAN groups. However, with the exception of PAI-1, which was greater in the OB-NAFLD than the LEAN and OB-NL groups, 24-hour plasma cytokine concentration areas-under-the-curve were not different between groups. The percentage of proinflammatory macrophages and plasma PAI-1 concentration areas-under-the-curve were inversely correlated with both hepatic and whole-body insulin sensitivity. Compared with exosomes from OB-NL participants, plasma and SAAT-derived exosomes from the OB-NAFLD group decreased insulin signaling in myotubes and hepatocytes.
+
+ CONCLUSIONS: Systemic insulin resistance in people with obesity and NAFLD is associated with increased plasma PAI-1 concentrations and both plasma and SAAT-derived exosomes. ClinicalTrials.gov number: NCT02706262 (https://clinicaltrials.gov/ct2/show/NCT02706262). Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cytokines). 0 (Insulin). 0 (Plasminogen Activator Inhibitor 1). 0 (SERPINE1 protein, human).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1053%2fj.gastro.2021.05.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fuchs&issn=0016-5085&title=Gastroenterology&atitle=Associations+Among+Adipose+Tissue+Immunology%2C+Inflammation%2C+Exosomes+and+Insulin+Sensitivity+in+People+With+Obesity+and+Nonalcoholic+Fatty+Liver+Disease.&volume=161&issue=3&spage=968&epage=981.e12&date=2021&doi=10.1053%2Fj.gastro.2021.05.008&pmid=34004161&sid=OVID:medline
+
+<858>
+Unique Identifier
+ 33999316
+Title
+ Association between pre-diagnostic circulating adipokines and colorectal cancer and adenoma in the CLUE II cohort.
+Source
+ Cancer Causes & Control. 32(8):871-881, 2021 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Marrone MT; Lu J; Visvanathan K; Joshu CE; Platz EA
+Authors Full Name
+ Marrone, Michael T; Lu, Jiayun; Visvanathan, Kala; Joshu, Corinne E; Platz, Elizabeth A.
+Institution
+ Marrone, Michael T. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Rm. E6133, Baltimore, MD, 21205, USA. mmarron6@jhu.edu.
+ Lu, Jiayun. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Rm. E6133, Baltimore, MD, 21205, USA.
+ Visvanathan, Kala. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Rm. E6133, Baltimore, MD, 21205, USA.
+ Visvanathan, Kala. Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins, Baltimore, MD, USA.
+ Joshu, Corinne E. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Rm. E6133, Baltimore, MD, 21205, USA.
+ Joshu, Corinne E. Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins, Baltimore, MD, USA.
+ Platz, Elizabeth A. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Rm. E6133, Baltimore, MD, 21205, USA.
+ Platz, Elizabeth A. Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins, Baltimore, MD, USA.
+ Platz, Elizabeth A. Department of Urology and the, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
+MeSH Subject Headings
+ *Adenoma/bl [Blood]
+ *Adipokines/bl [Blood]
+ Adiponectin/bl [Blood]
+ Aged
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ Cohort Studies
+ *Colorectal Neoplasms/di [Diagnosis]
+ Female
+ Humans
+ Leptin/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Prospective Studies
+ Risk Factors
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ Adenoma
+ Adipokines
+ Adiponectin
+ Colorectal cancer
+ Leptin
+ TNF-alpha
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Obesity is a known risk factor for colorectal cancer (CRC) and adenoma. Obese individuals have higher circulating concentrations of certain endocrine and immune factors produced by adipocytes thought to partially underlie the association between obesity and colorectal neoplasia. Thus, we evaluated the association of plasma concentrations of adiponectin, leptin, and soluble tumor necrosis factor receptor-2 (sTNFR2) with CRC and adenoma.
+
+ METHODS: We ascertained 193 CRC cases and 193 matched controls, and 131 colorectal adenoma cases and 131 matched controls who had had an endoscopy nested in the CLUE II cohort of Washington County, MD. Plasma markers were measured using ELISA. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from conditional logistic regression for quartiles of the plasma markers separately for CRC and adenoma.
+
+ RESULTS: Adjusting for leptin and adiponectin, sTNFR2 was positively associated with CRC only in men (Q4 vs. Q1: OR = 3.14, 95% CI 1.11-8.86), which was unchanged adjusting for BMI (3.46, 95% CI 1.19-10.06). Leptin and adiponectin were not associated with CRC risk overall or in men or women. Adiponectin, leptin, and sTNFR2 were not associated with adenoma risk overall or in men or women.
+
+ CONCLUSION: In this study, leptin and adiponectin were not associated with colorectal carcinogenesis and thus do not appear to underlie the association between obesity and colorectal carcinogenesis. sTNFR2, which we measured as a correlate of TNF-alpha, was positively associated with CRC in men adjusting for BMI, suggesting that TNF-alpha may influence colorectal carcinogenesis independent of adipocyte production.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs10552-021-01441-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Marrone&issn=0957-5243&title=Cancer+Causes+%26+Control&atitle=Association+between+pre-diagnostic+circulating+adipokines+and+colorectal+cancer+and+adenoma+in+the+CLUE+II+cohort.&volume=32&issue=8&spage=871&epage=881&date=2021&doi=10.1007%2Fs10552-021-01441-1&pmid=33999316&sid=OVID:medline
+
+<859>
+Unique Identifier
+ 33998291
+Title
+ Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity.
+Source
+ American Journal of Physiology - Endocrinology & Metabolism. 321(1):E105-E121, 2021 07 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kunz HE; Hart CR; Gries KJ; Parvizi M; Laurenti M; Dalla Man C; Moore N; Zhang X; Ryan Z; Polley EC; Jensen MD; Vella A; Lanza IR
+Author NameID
+ Dalla Man, Chiara; ORCID: https://orcid.org/0000-0002-4908-0596
+ Jensen, Michael D; ORCID: https://orcid.org/0000-0001-5589-8389
+ Vella, Adrian; ORCID: https://orcid.org/0000-0001-6493-7837
+ Lanza, Ian R; ORCID: https://orcid.org/0000-0002-9858-3384
+Authors Full Name
+ Kunz, Hawley E; Hart, Corey R; Gries, Kevin J; Parvizi, Mojtaba; Laurenti, Marcello; Dalla Man, Chiara; Moore, Natalie; Zhang, Xiaoyan; Ryan, Zachary; Polley, Eric C; Jensen, Michael D; Vella, Adrian; Lanza, Ian R.
+Institution
+ Kunz, Hawley E. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Hart, Corey R. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Gries, Kevin J. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Parvizi, Mojtaba. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Laurenti, Marcello. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Dalla Man, Chiara. Biomedical Engineering and Physiology Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota.
+ Moore, Natalie. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Zhang, Xiaoyan. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Ryan, Zachary. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Polley, Eric C. Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota.
+ Jensen, Michael D. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Vella, Adrian. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Lanza, Ian R. Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+MeSH Subject Headings
+ Abdominal Fat/ch [Chemistry]
+ Abdominal Fat/me [Metabolism]
+ *Abdominal Fat/pa [Pathology]
+ Adult
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ Cell Count
+ Cytokines/an [Analysis]
+ Female
+ Gene Expression
+ Humans
+ Inflammation/ge [Genetics]
+ *Inflammation/pa [Pathology]
+ *Insulin Resistance
+ *Macrophages/pa [Pathology]
+ Male
+ Middle Aged
+ Mitochondria, Muscle/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Obesity/pp [Physiopathology]
+ Oxygen Consumption
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ adipose tissue resident macrophages
+ inflammation
+ insulin sensitivity
+ mitochondria
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is accompanied by numerous systemic and tissue-specific derangements, including systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal muscle. Despite growing recognition that adipose tissue dysfunction plays a role in obesity-related disorders, the relationship between adipose tissue inflammation and other pathological features of obesity is not well-understood. We assessed macrophage populations and measured the expression of inflammatory cytokines in abdominal adipose tissue biopsies in 39 nondiabetic adults across a range of body mass indexes (BMI 20.5-45.8 kg/m2). Skeletal muscle biopsies were used to evaluate mitochondrial respiratory capacity, ATP production capacity, coupling, and reactive oxygen species production. Insulin sensitivity (SI) and beta cell responsivity were determined from test meal postprandial glucose, insulin, c-peptide, and triglyceride kinetics. We examined the relationships between adipose tissue inflammatory markers, systemic inflammatory markers, SI, and skeletal muscle mitochondrial physiology. BMI was associated with increased adipose tissue and systemic inflammation, reduced SI, and reduced skeletal muscle mitochondrial oxidative capacity. Adipose-resident macrophage numbers were positively associated with circulating inflammatory markers, including tumor necrosis factor-alpha (TNFalpha) and C-reactive protein (CRP). Local adipose tissue inflammation and circulating concentrations of TNFalpha and CRP were negatively associated with SI, and circulating concentrations of TNFalpha and CRP were also negatively associated with skeletal muscle oxidative capacity. These results demonstrate that obese humans exhibit increased adipose tissue inflammation concurrently with increased systemic inflammation, reduced insulin sensitivity, and reduced muscle oxidative capacity and suggest that adipose tissue and systemic inflammation may drive obesity-associated metabolic derangements. NEW AND NOTEWORTHY Adipose inflammation is proposed to be at the nexus of the systemic inflammation and metabolic derangements associated with obesity. The present study provides evidence to support adipose inflammation as a central feature of the pathophysiology of obesity. Adipose inflammation is associated with systemic and peripheral metabolic derangements, including increased systemic inflammation, reduced insulin sensitivity, and reduced skeletal muscle mitochondrial respiration.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Tumor Necrosis Factor-alpha). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1152%2fajpendo.00070.2021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kunz&issn=0193-1849&title=American+Journal+of+Physiology+-+Endocrinology+%26+Metabolism&atitle=Adipose+tissue+macrophage+populations+and+inflammation+are+associated+with+systemic+inflammation+and+insulin+resistance+in+obesity.&volume=321&issue=1&spage=E105&epage=E121&date=2021&doi=10.1152%2Fajpendo.00070.2021&pmid=33998291&sid=OVID:medline
+
+<860>
+Unique Identifier
+ 33992509
+Title
+ The effects of breaking sedentary time with different intensity exercise bouts on energy metabolism: A randomized cross-over controlled trial.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(6):1879-1889, 2021 06 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hatamoto Y; Yoshimura E; Takae R; Komiyama T; Matsumoto M; Higaki Y; Tanaka H
+Authors Full Name
+ Hatamoto, Yoichi; Yoshimura, Eiichi; Takae, Rie; Komiyama, Takaaki; Matsumoto, Mai; Higaki, Yasuki; Tanaka, Hiroaki.
+Institution
+ Hatamoto, Yoichi. The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan; Department of Nutrition and Metabolism, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan. Electronic address: yhatamoto@nibiohn.go.jp.
+ Yoshimura, Eiichi. Department of Nutrition and Metabolism, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan. Electronic address: eyoshi@nibiohn.go.jp.
+ Takae, Rie. The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan; Faculty of Nursing and Nutrition, University of Nagasaki, Siebold, 1-1-1 Manabino, Nagayo-cho, Nishi-Sonogi-gun, Nagasaki, 851-2195, Japan. Electronic address: Irietty.tl@gmail.com.
+ Komiyama, Takaaki. Center for Education in Liberal Arts and Sciences, Osaka University, 1-17 Machikaneyama, Toyonaka, 560-0043, Osaka, Japan. Electronic address: mt.komi51@gmail.com.
+ Matsumoto, Mai. Department of Nutritional Epidemiology and Shokuiku, National Institute of Biomedical Innovation, Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan. Electronic address: m-matsumoto@nibiohn.go.jp.
+ Higaki, Yasuki. The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: higaki@fukuoka-u.ac.jp.
+ Tanaka, Hiroaki. The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Calorimetry, Indirect
+ Cross-Over Studies
+ Energy Intake
+ *Energy Metabolism
+ Humans
+ Japan
+ Lactic Acid/bl [Blood]
+ Male
+ Meals
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ *Physical Conditioning, Human
+ *Running
+ *Sedentary Behavior
+ Time Factors
+ Young Adult
+Keyword Heading
+ Breaking sedentary time
+ Continuous glucose monitoring
+ Energy expenditure
+ Exercise intensity
+ Postprandial glucose
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Breaking up sedentary periods, particularly with light activity, increases total energy expenditure (EE), and helps provide better glycemic control. However, the effects of activities of various intensities to interrupt prolonged sedentary time are unclear. The purpose of the present study was to examine potential differences in glycemic control and EE from breaking up sedentary time with short exercise bouts of different intensities.
+
+ METHODS AND RESULTS: Nine overweight/obesity young men underwent whole body indirect calorimetry at 19:00 on day 1 and stayed overnight. After awakening on day 2, they performed short duration jogging every 30 min over 8 h (16-time bouts in total) under 3 different conditions with the same running distance: (1) lactate threshold (LT) for 2 min, (2) 60% LT for 200 s, and (3) onset of blood lactate accumulation (OBLA) for 75 s. The 24-h EE and interstitial glucose concentration (from 8:00 to 19:00 on day 2) was continuously measured throughout the trials. The standard deviation during intervention and indexes of postprandial of the interstitial glucose concentration was significantly lower at LT and OBLA than at 60% LT (p < 0.05). The 24-h EE was not significantly different among conditions, but EE at OBLA during intervention was slightly but significantly higher than at 60% LT and LT.
+
+ CONCLUSION: Breaking up sedentary time with short-duration jogging at LT and with OBLA intensities may have better glycemic control and increased use of carbohydrate as a fuel, while short-duration a jogging at OBLA intensity may increase EE.
+
+ TRIAL REGISTRATION: UMIN000041361. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 33X04XA5AT (Lactic Acid).
+Publication Type
+ Comparative Study. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.numecd.2021.03.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hatamoto&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=The+effects+of+breaking+sedentary+time+with+different+intensity+exercise+bouts+on+energy+metabolism%3A+A+randomized+cross-over+controlled+trial.&volume=31&issue=6&spage=1879&epage=1889&date=2021&doi=10.1016%2Fj.numecd.2021.03.006&pmid=33992509&sid=OVID:medline
+
+<861>
+Unique Identifier
+ 33986637
+Title
+ The Formidable yet Unresolved Interplay between Endometriosis and Obesity. [Review]
+Source
+ Thescientificworldjournal. 2021:6653677, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pantelis A; Machairiotis N; Lapatsanis DP
+Author NameID
+ Pantelis, Athanasios; ORCID: https://orcid.org/0000-0002-1788-2826
+ Machairiotis, Nikolaos; ORCID: https://orcid.org/0000-0003-2260-9709
+Authors Full Name
+ Pantelis, Athanasios; Machairiotis, Nikolaos; Lapatsanis, Dimitris P.
+Institution
+ Pantelis, Athanasios. Surgeon, 4th Department of Surgery, Evaggelismos General Hospital of Athens, Ipsilantou 45, Athens 106 76, Greece.
+ Machairiotis, Nikolaos. Fellow in Endometriosis and Minimal Access Surgery, Northwick Park, Central Middlesex and Ealing Hospitals, London North West University Heathcare, NHS Trust, London, UK.
+ Lapatsanis, Dimitris P. Surgeon, 4th Department of Surgery, Evaggelismos General Hospital of Athens, Ipsilantou 45, Athens 106 76, Greece.
+MeSH Subject Headings
+ Adiponectin/ge [Genetics]
+ Adiponectin/me [Metabolism]
+ Adiposity/ge [Genetics]
+ Anthropometry
+ Bariatric Surgery/mt [Methods]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ Chemokines/ge [Genetics]
+ Chemokines/me [Metabolism]
+ Endometriosis/di [Diagnosis]
+ *Endometriosis/ge [Genetics]
+ Endometriosis/pa [Pathology]
+ Endometriosis/su [Surgery]
+ Female
+ *Gene Expression Regulation
+ *Gene-Environment Interaction
+ Ghrelin/ge [Genetics]
+ Ghrelin/me [Metabolism]
+ Humans
+ Leptin/ge [Genetics]
+ Leptin/me [Metabolism]
+ Obesity/di [Diagnosis]
+ *Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ Obesity/su [Surgery]
+ *Phenomics/mt [Methods]
+ Phenotype
+Abstract
+ Obesity and endometriosis are two very common entities, yet there is uncertainty on their exact relationship. Observational studies have repeatedly shown an inverse correlation between endometriosis and a low body mass index (BMI). However, obesity does not protect against endometriosis and on the contrary an increased BMI may lead to more severe forms of the disease. Besides, BMI is not accurate in all cases of obesity. Consequently, other anthropometric and phenomic traits have been studied, including body adiposity content, as well as the effect of BMI early in life on the manifestation of endometriosis in adulthood. Some studies have shown that the phenotypic inverse correlation between the two entities has a genetic background; however, others have indicated that certain polymorphisms are linked with endometriosis in females with increased BMI. The advent of metabolic bariatric surgery and pertinent research have led to the emergence of biomolecules that may be pivotal in understanding the pathophysiological interaction of the two entities, especially in the context of angiogenesis and inflammation. Future research should focus on three objectives: detection and interpretation of obesity-related biomarkers in experimental models with endometriosis; integration of endometriosis-related queries into bariatric registries; and multidisciplinary approach and collaboration among specialists. Copyright © 2021 Athanasios Pantelis et al.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Chemokines). 0 (Ghrelin). 0 (LEP protein, human). 0 (Leptin). 0 (RARRES2 protein, human).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1155%2f2021%2f6653677
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pantelis&issn=1537-744X&title=Thescientificworldjournal&atitle=The+Formidable+yet+Unresolved+Interplay+between+Endometriosis+and+Obesity.&volume=2021&issue=&spage=6653677&epage=&date=2021&doi=10.1155%2F2021%2F6653677&pmid=33986637&sid=OVID:medline
+
+<862>
+Unique Identifier
+ 33983831
+Title
+ From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure With Preserved Ejection Fraction Paradigm Revisited. [Review]
+Source
+ Circulation Research. 128(10):1451-1467, 2021 05 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Paulus WJ; Zile MR
+Authors Full Name
+ Paulus, Walter J; Zile, Michael R.
+Institution
+ Paulus, Walter J. Amsterdam University Medical Centers, The Netherlands (W.J.P.).
+ Zile, Michael R. RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston (M.R.Z.).
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Collagen/me [Metabolism]
+ Comorbidity
+ Connectin/me [Metabolism]
+ Extracellular Matrix/ph [Physiology]
+ Fibrosis
+ Heart Failure/et [Etiology]
+ *Heart Failure/me [Metabolism]
+ Heart Failure/pp [Physiopathology]
+ Heart Failure/th [Therapy]
+ Hemodynamics
+ Humans
+ Hypertension/pp [Physiopathology]
+ Immunity, Cellular
+ Inflammation/pp [Physiopathology]
+ Laminin/me [Metabolism]
+ Machine Learning
+ Myocardium/im [Immunology]
+ *Myocardium/me [Metabolism]
+ Myocardium/pa [Pathology]
+ Myocytes, Cardiac/me [Metabolism]
+ Nitric Oxide Synthase Type II/me [Metabolism]
+ Obesity/me [Metabolism]
+ Stroke Volume/ph [Physiology]
+Keyword Heading
+ biomarker
+ fibrosis
+ heart failure
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In accordance with the comorbidity-inflammation paradigm, comorbidities and especially metabolic comorbidities are presumed to drive development and severity of heart failure with preserved ejection fraction through a cascade of events ranging from systemic inflammation to myocardial fibrosis. Recently, novel experimental and clinical evidence emerged, which strengthens the validity of the inflammatory/profibrotic paradigm. This evidence consists among others of (1) myocardial infiltration by immunocompetent cells not only because of an obesity-induced metabolic load but also because of an arterial hypertension-induced hemodynamic load. The latter is sensed by components of the extracellular matrix like basal laminin, which also interact with cardiomyocyte titin; (2) expression in cardiomyocytes of inducible nitric oxide synthase because of circulating proinflammatory cytokines. This results in myocardial accumulation of degraded proteins because of a failing unfolded protein response; (3) definition by machine learning algorithms of phenogroups of patients with heart failure with preserved ejection fraction with a distinct inflammatory/profibrotic signature; (4) direct coupling in mediation analysis between comorbidities, inflammatory biomarkers, and deranged myocardial structure/function with endothelial expression of adhesion molecules already apparent in early preclinical heart failure with preserved ejection fraction (HF stage A, B). This new evidence paves the road for future heart failure with preserved ejection fraction treatments such as biologicals directed against inflammatory cytokines, stimulation of protein ubiquitylation with phosphodiesterase 1 inhibitors, correction of titin stiffness through natriuretic peptide-particulate guanylyl cyclase-PDE9 (phosphodiesterase 9) signaling and molecular/cellular regulatory mechanisms that control myocardial fibrosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Connectin). 0 (Laminin). 0 (TTN protein, human). 9007-34-5 (Collagen). EC 1-14-13-39 (NOS2 protein, human). EC 1-14-13-39 (Nitric Oxide Synthase Type II).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S.. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1161%2fCIRCRESAHA.121.318159
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Paulus&issn=0009-7330&title=Circulation+Research&atitle=From+Systemic+Inflammation+to+Myocardial+Fibrosis%3A+The+Heart+Failure+With+Preserved+Ejection+Fraction+Paradigm+Revisited.&volume=128&issue=10&spage=1451&epage=1467&date=2021&doi=10.1161%2FCIRCRESAHA.121.318159&pmid=33983831&sid=OVID:medline
+
+<863>
+Unique Identifier
+ 33980884
+Title
+ Awareness, treatment, control, and determinants of dyslipidemia among adults in China.
+Source
+ Scientific Reports. 11(1):10056, 2021 05 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Opoku S; Gan Y; Yobo EA; Tenkorang-Twum D; Yue W; Wang Z; Lu Z
+Authors Full Name
+ Opoku, Sampson; Gan, Yong; Yobo, Emmanuel Addo; Tenkorang-Twum, David; Yue, Wei; Wang, Zhihong; Lu, Zuxun.
+Institution
+ Opoku, Sampson. Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China. samblessvissions@gmail.com.
+ Gan, Yong. Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China.
+ Yobo, Emmanuel Addo. Department of Medicine, SUNY Upstate Medical University, New York, USA.
+ Tenkorang-Twum, David. Department of Adult Health, School of Nursing and Midwifery, University of Ghana, Accra, Ghana.
+ Yue, Wei. Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
+ Wang, Zhihong. Department of Neurology, Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, Guangdong, China.
+ Lu, Zuxun. Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China. luac6@163.com.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/bl [Blood]
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Dyslipidemias/ep [Epidemiology]
+ Dyslipidemias/pa [Pathology]
+ *Dyslipidemias/pc [Prevention & Control]
+ Dyslipidemias/px [Psychology]
+ Female
+ *Health Knowledge, Attitudes, Practice
+ Humans
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prevalence
+ Risk Factors
+ Rural Population
+ Surveys and Questionnaires
+ *Triglycerides/bl [Blood]
+Abstract
+ Effective management of dyslipidemia is important. This study aimed to determine the awareness, treatment, control, and determinants of dyslipidemia in middle-aged and older Chinese adults in China. Using data from the 2015 China National Stroke Screening and Prevention Project (CNSSPP), a nationally representative sample of 135,403 Chinese adults aged 40 years or more were included in this analysis. Dyslipidemia was defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults final report (NCEP-ATP III) and the 2016 Chinese guidelines for the management of dyslipidemia in adults. Models were constructed to adjust for subjects' characteristics with bivariate and multivariable logistic regression analyses. Overall, 51.1% of the subjects were women. Sixty-four percent were aware of their condition, of whom 18.9% received treatment, and of whom 7.2% had adequately controlled dyslipidemia. Dyslipidemia treatment was higher in men from rural areas than their urban counterparts. The multivariable logistic regression models revealed that women, urban residents, and general obesity were positively related to awareness. Women, married respondents, and current drinkers had higher odds of treatment. Age group, overweight, general obesity, urban residence, and women were independent determinants of control. Dyslipidemia awareness rate was moderately high, but treatment and control rates were low. Results can be used to develop policies and health promotion strategies with special focus on middle-aged and older adults.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1038%2fs41598-021-89401-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Opoku&issn=2045-2322&title=Scientific+Reports&atitle=Awareness%2C+treatment%2C+control%2C+and+determinants+of+dyslipidemia+among+adults+in+China.&volume=11&issue=1&spage=10056&epage=&date=2021&doi=10.1038%2Fs41598-021-89401-2&pmid=33980884&sid=OVID:medline
+
+<864>
+Unique Identifier
+ 33978383
+Title
+ Application Value of Lipoprotein-Associated Phospholipase A2 Expression Level in Evaluating the Risk of Major Bleeding in Gestational Diabetes.
+Source
+ Clinical Laboratory. 67(5), 2021 May 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li Y; Wang J; Wang K; Peng T; Liu H; Zheng H; Hu Q
+Authors Full Name
+ Li, Ying; Wang, Jinjing; Wang, Kai; Peng, Tao; Liu, Hongyan; Zheng, Hong; Hu, Qiong.
+MeSH Subject Headings
+ *1-Alkyl-2-acetylglycerophosphocholine Esterase
+ Biomarkers
+ Diabetes, Gestational/di [Diagnosis]
+ *Diabetes, Gestational
+ Female
+ *Hemorrhage
+ Humans
+ Infant, Newborn
+ Obesity
+ Pregnancy
+ Risk Factors
+Abstract
+ BACKGROUND: Studies have shown that obesity and lipid metabolism disorders can lead to increased Lp-PLA2 ac-tivity in the body. However, few studies have reported the correlation between Lp-PLA2 and postpartum hemorrhage in pregnant women with GMD.
+
+ METHODS: Clinical data was collected from 43 pregnant women with gestational diabetes combined with postpartum hemorrhage and 50 pregnant women with postpartum diabetes without postpartum bleeding during the same period. Lp-PLA2 expression levels in the serum of pregnant women in both groups were detected. The predictive value of Lp-PLA2 expression level for postpartum hemorrhage was clarified.
+
+ RESULTS: (1) From 20w to 32w pregnancy, the serum Lp-PLA2 levels of pregnant women in both groups showed a gradual increasing trend. (2) The serum Lp-PLA2 level of the pregnant women in the research group was significantly higher (p < 0.001). (3) Binary logistic regression analysis shows that Lp-PLA2 level has a good correlation with postpartum major bleeding. (4) Comparing of Lp-PLA2 levels in different gestational weeks with respect to its efficacy for predicting postpartum hemorrhage found that the sensitivity and specificity of 24w Lp-PLA2 levels are higher than other gestational weeks, and the area under the 24w parameter curve (0.955) > 32w area under the parameter curve (0.952) > area under the 20w parameter curve (0.940) > area under the 28w parameter curve (0.887). (5) The birth weight of the newborn in the research group was significantly heavier (p < 0.001).
+
+ CONCLUSIONS: Dynamic monitoring of the expression level of Lp-PLA2 in the serum of pregnant women can predict the risk of postpartum hemorrhage in pregnant women at an early stage and help optimize the rescue plan for postpartum hemorrhage.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-1-1-47 (1-Alkyl-2-acetylglycerophosphocholine Esterase). EC 3-1-1-47 (PLA2G7 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.7754%2fClin.Lab.2020.200906
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1433-6510&title=Clinical+Laboratory&atitle=Application+Value+of+Lipoprotein-Associated+Phospholipase+A2+Expression+Level+in+Evaluating+the+Risk+of+Major+Bleeding+in+Gestational+Diabetes.&volume=67&issue=5&spage=&epage=&date=2021&doi=10.7754%2FClin.Lab.2020.200906&pmid=33978383&sid=OVID:medline
+
+<865>
+Unique Identifier
+ 33960018
+Title
+ Plantar involvement correlates with obesity, pain and impaired mobility in epidermolysis bullosa simplex: a retrospective cohort study.
+Source
+ Journal of the European Academy of Dermatology & Venereology. 35(10):2097-2104, 2021 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Reimer-Taschenbrecker A; Hess M; Hotz A; Fischer J; Bruckner-Tuderman L; Has C
+Author NameID
+ Reimer-Taschenbrecker, A; ORCID: https://orcid.org/0000-0002-3378-4476
+ Has, C; ORCID: https://orcid.org/0000-0001-6066-507X
+Authors Full Name
+ Reimer-Taschenbrecker, A; Hess, M; Hotz, A; Fischer, J; Bruckner-Tuderman, L; Has, C.
+Institution
+ Reimer-Taschenbrecker, A. Department of Dermatology, Medical Faculty and Medical Center, University of Freiburg, Freiburg, Germany.
+ Hess, M. Institute of Medical Biometry and Statistics, Medical Faculty and Medical Center, University of Freiburg, Freiburg, Germany.
+ Hotz, A. Institute of Human Genetics, Medical Faculty and Medical Center, University of Freiburg, Freiburg, Germany.
+ Fischer, J. Institute of Human Genetics, Medical Faculty and Medical Center, University of Freiburg, Freiburg, Germany.
+ Bruckner-Tuderman, L. Department of Dermatology, Medical Faculty and Medical Center, University of Freiburg, Freiburg, Germany.
+ Has, C. Department of Dermatology, Medical Faculty and Medical Center, University of Freiburg, Freiburg, Germany.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Child, Preschool
+ *Epidermolysis Bullosa
+ Epidermolysis Bullosa Simplex/co [Complications]
+ Epidermolysis Bullosa Simplex/ge [Genetics]
+ *Epidermolysis Bullosa Simplex
+ Humans
+ Obesity/co [Complications]
+ Pain
+ Retrospective Studies
+Abstract
+ BACKGROUND: Epidermolysis bullosa simplex (EBS) is the most common type of EB, a group of rare genodermatoses. Affected individuals suffer from skin blistering and report a high disease burden. In some EBS subtypes, plantar keratoderma (PK) has been described.
+
+ OBJECTIVES: This study investigated the presence and correlation of PK with body mass index, pain and mobility in EBS.
+
+ METHODS: Individuals (n = 157) with genetically characterized EBS were included in this retrospective cohort study, and clinical data were collected over 16 years (referral patients to the largest German EB centre). Descriptive statistics and mixed linear models were used to assess correlations.
+
+ RESULTS: PK was found in 75.8% of patients beginning at a mean age of 4.3 years. Both focal and diffuse PK were observed, and 60% of adults with localized and severe EBS were preobese or obese, with ~30% of patients reporting severely reduced mobility. The presence of PK, especially diffuse PK, correlated significantly with local infections, obesity, pain and requirement of a wheelchair.
+
+ CONCLUSION: Along with treating skin fragility and blistering, PK should be considered a potential marker of increased morbidity and may represent a target of EBS therapy development. Copyright © 2021 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1111%2fjdv.17336
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Reimer-Taschenbrecker&issn=0926-9959&title=Journal+of+the+European+Academy+of+Dermatology+%26+Venereology&atitle=Plantar+involvement+correlates+with+obesity%2C+pain+and+impaired+mobility+in+epidermolysis+bullosa+simplex%3A+a+retrospective+cohort+study.&volume=35&issue=10&spage=2097&epage=2104&date=2021&doi=10.1111%2Fjdv.17336&pmid=33960018&sid=OVID:medline
+
+<866>
+Unique Identifier
+ 33959099
+Title
+ Body Adiposity, But Not Elements of Objectively Measured Sedentary Behavior or Physical Activity, Is Associated With Circulating Liver Enzymes in Adults With Overweight and Obesity.
+Source
+ Frontiers in Endocrinology. 12:655756, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Laine S; Sjoros T; Vaha-Ypya H; Garthwaite T; Loyttyniemi E; Sievanen H; Vasankari T; Knuuti J; Heinonen IHA
+Authors Full Name
+ Laine, Saara; Sjoros, Tanja; Vaha-Ypya, Henri; Garthwaite, Taru; Loyttyniemi, Eliisa; Sievanen, Harri; Vasankari, Tommi; Knuuti, Juhani; Heinonen, Ilkka H A.
+Institution
+ Laine, Saara. Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
+ Sjoros, Tanja. Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
+ Vaha-Ypya, Henri. The UKK-Institute for Health Promotion Research, Tampere, Finland.
+ Garthwaite, Taru. Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
+ Loyttyniemi, Eliisa. Department of Biostatistics, University of Turku, Turku, Finland.
+ Sievanen, Harri. The UKK-Institute for Health Promotion Research, Tampere, Finland.
+ Vasankari, Tommi. The UKK-Institute for Health Promotion Research, Tampere, Finland.
+ Vasankari, Tommi. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
+ Knuuti, Juhani. Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
+ Heinonen, Ilkka H A. Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
+ Heinonen, Ilkka H A. Rydberg Laboratory of Applied Sciences, University of Halmstad, Halmstad, Sweden.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Aged
+ Alanine Transaminase/bl [Blood]
+ Aspartate Aminotransferases/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Exercise
+ Female
+ Finland/ep [Epidemiology]
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ *Liver/en [Enzymology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Obesity/pa [Pathology]
+ Overweight/bl [Blood]
+ *Overweight/ep [Epidemiology]
+ Overweight/pa [Pathology]
+ Prognosis
+ Retrospective Studies
+ *Sedentary Behavior
+ gamma-Glutamyltransferase/bl [Blood]
+Keyword Heading
+ adiposity
+ liver
+ liver enzymes
+ obesity
+ physical activity
+ sedentary behavior
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: We studied the associations between accelerometer-measured sedentary behavior (SB) and habitual physical activity (PA) as well as markers of body adiposity and other cardiometabolic risk factors with liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT).
+
+ Methods: A total of 144 middle-aged adults (mean age 57 (SD 6.5) years) with overweight or obesity (mean body mass index [BMI] 31.8 [SD 3.9] kg/m2) participated. Different components of SB (sitting, lying) and PA (standing, breaks in SB, daily steps, light PA, moderate-to-vigorous PA and total PA) were measured with validated hip-worn accelerometers for four consecutive weeks (mean 25 days, [SD 4]). Fasting venous blood samples were analysed using standard assays. The associations were examined with Pearson's partial correlation coefficient test and linear mixed model.
+
+ Results: Among 102 women and 42 men accelerometer measured SB or the elements of PA were not associated with circulating liver enzymes. When adjusted for age and sex, liver enzymes correlated positively with BMI and waist circumference (WC) (ALT r=0.34, p<0.0001, r=0.41, < 0.0001, AST r=0.17, p=0.049, r=0.26, p=0.002, GGT r=0.29, p=0.0005, r=0.32, p < 0.0001, respectively). SB proportion associated positively with BMI (r=0.21, p=0.008) and WC (r=0.27, p=0.001). Components of PA associated negatively with BMI (MVPA r=-0.23, p=0.005, daily steps r=-0.30, p<0.0001 and breaks in sedentary time r=-0.32, p<0.0001), as well as with WC (breaks in SB r=-0.35, p<0.0001, MVPA r=-0.26, p=0.002, daily steps r=-0.31, p<0.0001, standing time r=-0.27, p=0.001). Liver enzymes associated positively with common cardiometabolic markers such as resting heart rate (ALT; beta=0.17, p=0.03, AST; beta=0.25, p=0.002, GGT; beta=0.23, p=0.004) and systolic/diastolic blood pressure (ALT beta=0.20, p=0.01, beta=0.22, p=0.005, AST (only diastolic) beta=0.23, p=0.006, GGT beta=0.19, p=0.02, = 0.23, p=0.004, respectively), fasting insulin (ALT beta=0.41, p<0.0001, AST beta=0.36, p=0.0003, GGT beta=0.20, p=0.04) and insulin resistance index (ALT beta=0.42, p<0.0001, AST beta=0.36, p=0.0003, GGT beta=0.21, p=0.03), even after adjustment with BMI.
+
+ Conclusions: Liver enzymes correlate with body adiposity and appear to cluster with other common cardiometabolic risk factors, even independently of body adiposity. SB and PA appear not to be essential in modulating the levels of circulating liver enzymes. Copyright © 2021 Laine, Sjoros, Vaha-Ypya, Garthwaite, Loyttyniemi, Sievanen, Vasankari, Knuuti and Heinonen.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-3-2-2 (gamma-Glutamyltransferase). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3389%2ffendo.2021.655756
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Laine&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Body+Adiposity%2C+But+Not+Elements+of+Objectively+Measured+Sedentary+Behavior+or+Physical+Activity%2C+Is+Associated+With+Circulating+Liver+Enzymes+in+Adults+With+Overweight+and+Obesity.&volume=12&issue=&spage=655756&epage=&date=2021&doi=10.3389%2Ffendo.2021.655756&pmid=33959099&sid=OVID:medline
+
+<867>
+Unique Identifier
+ 33951242
+Title
+ The novel collagen matrikine, endotrophin, is associated with mortality and cardiovascular events in patients with atherosclerosis.
+Source
+ Journal of Internal Medicine. 290(1):179-189, 2021 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Holm Nielsen S; Edsfeldt A; Tengryd C; Gustafsson H; Shore AC; Natali A; Khan F; Genovese F; Bengtsson E; Karsdal M; Leeming DJ; Nilsson J; Goncalves I
+Author NameID
+ Holm Nielsen, S; ORCID: https://orcid.org/0000-0002-4612-1014
+ Edsfeldt, A; ORCID: https://orcid.org/0000-0002-2691-9192
+ Bengtsson, E; ORCID: https://orcid.org/0000-0001-7075-1772
+ Nilsson, J; ORCID: https://orcid.org/0000-0002-9752-7479
+Authors Full Name
+ Holm Nielsen, S; Edsfeldt, A; Tengryd, C; Gustafsson, H; Shore, A C; Natali, A; Khan, F; Genovese, F; Bengtsson, E; Karsdal, M; Leeming, D J; Nilsson, J; Goncalves, I.
+Institution
+ Holm Nielsen, S. Nordic Bioscience, Herlev, Denmark.
+ Holm Nielsen, S. Department of Biomedicine and Biotechnology, Technical University of Denmark, Lyngby, Denmark.
+ Edsfeldt, A. Department of Cardiology, Skane University Hospital, Malmo, Sweden.
+ Edsfeldt, A. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Edsfeldt, A. Wallenberg Center for Molecular Medicine, Lund University, Malmo, Sweden.
+ Tengryd, C. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Gustafsson, H. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Shore, A C. Diabetes and Vascular Medicine, University of Exeter, Medical School, National Institute for Health Research Exeter Clinical Research Facility, Exeter, UK.
+ Natali, A. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
+ Khan, F. Division of Molecular and Clinical medicine, University of Dundee, Dundee, UK.
+ Genovese, F. Nordic Bioscience, Herlev, Denmark.
+ Bengtsson, E. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Karsdal, M. Nordic Bioscience, Herlev, Denmark.
+ Leeming, D J. Nordic Bioscience, Herlev, Denmark.
+ Nilsson, J. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Goncalves, I. Department of Cardiology, Skane University Hospital, Malmo, Sweden.
+ Goncalves, I. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+MeSH Subject Headings
+ Aged
+ *Atherosclerosis/bl [Blood]
+ *Atherosclerosis/co [Complications]
+ Atherosclerosis/mo [Mortality]
+ Biomarkers/bl [Blood]
+ *Carotid Stenosis/bl [Blood]
+ *Carotid Stenosis/co [Complications]
+ Carotid Stenosis/mo [Mortality]
+ Cause of Death
+ *Collagen Type VI/bl [Blood]
+ Diabetes Complications
+ Diabetes Mellitus/bl [Blood]
+ Female
+ Heart Disease Risk Factors
+ Humans
+ Hypertension/bl [Blood]
+ Hypertension/co [Complications]
+ Male
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Peptide Fragments/bl [Blood]
+ *Plaque, Atherosclerotic/bl [Blood]
+ *Plaque, Atherosclerotic/co [Complications]
+ Plaque, Atherosclerotic/mo [Mortality]
+ Smoking/ae [Adverse Effects]
+ Smoking/bl [Blood]
+Keyword Heading
+ atherosclerosis
+ biomarkers
+ collagen
+ endotrophin
+ extracellular matrix
+ inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Rupture of atherosclerotic plaques is the major cause of acute cardiovascular events. The biomarker PRO-C6 measuring Endotrophin, a matrikine of collagen type VI, may provide valuable information detecting subjects in need of intensified strategies for secondary prevention.
+
+ OBJECTIVE: In this study, we evaluate endotrophin in human atherosclerotic plaques and circulating levels of PRO-C6 in patients with atherosclerosis, to determine the predictive potential of the biomarker.
+
+ METHODS: Sections from the stenotic human carotid plaques were stained with the PRO-C6 antibody. PRO-C6 was measured in serum of patients enrolled in the Carotid Plaque Imagining Project (CPIP) (discovery cohort, n = 577) and the innovative medicines initiative surrogate markers for micro- and macrovascular hard end-points for innovative diabetes tools (IMI-SUMMIT, validation cohort, n = 1,378). Median follow-up was 43 months. Kaplan-Meier curves and log-rank tests were performed in the discovery cohort. Cox proportional hazard regression analysis (HR with 95% CI) was used in the discovery cohort and binary logistic regression (OR with 95% CI) in the validation cohort.
+
+ RESULTS: PRO-C6 was localized in the core and shoulder of the atherosclerotic plaque. In the discovery cohort, PRO-C6 independently predicted future cardiovascular events (HR 1.089 [95% CI 1.019 -1.164], p = 0.01), cardiovascular death (HR 1.118 [95% CI 1.008 -1.241], p = 0.04) and all-cause death (HR 1.087 [95% CI 1.008 -1.172], p = 0.03). In the validation cohort, PRO-C6 predicted future cardiovascular events (OR 1.063 [95% CI 1.011 -1.117], p = 0.017).
+
+ CONCLUSION: PRO-C6 is present in the atherosclerotic plaque and associated with future cardiovascular events, cardiovascular death and all-cause mortality in two large prospective cohorts. Copyright © 2021 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Collagen Type VI). 0 (Peptide Fragments). 0 (endotrophin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1111%2fjoim.13253
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Holm+Nielsen&issn=0954-6820&title=Journal+of+Internal+Medicine&atitle=The+novel+collagen+matrikine%2C+endotrophin%2C+is+associated+with+mortality+and+cardiovascular+events+in+patients+with+atherosclerosis.&volume=290&issue=1&spage=179&epage=189&date=2021&doi=10.1111%2Fjoim.13253&pmid=33951242&sid=OVID:medline
+
+<868>
+Unique Identifier
+ 33948786
+Title
+ Association of bone biomarkers with advanced atherosclerotic disease in people with overweight/obesity.
+Source
+ Endocrine. 73(2):339-346, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Del Toro R; Cavallari I; Tramontana F; Park K; Strollo R; Valente L; De Pascalis M; Grigioni F; Pozzilli P; Buzzetti R; Napoli N; Maddaloni E
+Author NameID
+ Del Toro, Rossella; ORCID: https://orcid.org/0000-0001-8925-4020
+Authors Full Name
+ Del Toro, Rossella; Cavallari, Ilaria; Tramontana, Flavia; Park, Kyoungmin; Strollo, Rocky; Valente, Luciana; De Pascalis, Mariangela; Grigioni, Francesco; Pozzilli, Paolo; Buzzetti, Raffaella; Napoli, Nicola; Maddaloni, Ernesto.
+Institution
+ Del Toro, Rossella. Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy. r.deltoro@unicampus.it.
+ Cavallari, Ilaria. Department of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Rome, Italy.
+ Tramontana, Flavia. Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
+ Park, Kyoungmin. Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
+ Strollo, Rocky. Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
+ Valente, Luciana. Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
+ De Pascalis, Mariangela. Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
+ Grigioni, Francesco. Department of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Rome, Italy.
+ Pozzilli, Paolo. Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
+ Buzzetti, Raffaella. Experimental Medicine Department, Sapienza University of Rome, Rome, Italy.
+ Napoli, Nicola. Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
+ Maddaloni, Ernesto. Experimental Medicine Department, Sapienza University of Rome, Rome, Italy.
+MeSH Subject Headings
+ Adaptor Proteins, Signal Transducing/bl [Blood]
+ Aged
+ Atherosclerosis/dg [Diagnostic Imaging]
+ *Atherosclerosis
+ Biomarkers
+ Female
+ Glucuronidase/bl [Blood]
+ Humans
+ Klotho Proteins
+ Male
+ Middle Aged
+ Obesity
+ Osteopontin/bl [Blood]
+ Osteoprotegerin/bl [Blood]
+ *Osteoprotegerin
+ Overweight
+Keyword Heading
+ Atherosclerosis
+ Bone biomarkers
+ Bone-vascular axis
+ Cardiovascular disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: A growing body of evidence suggests a potential link between bone metabolism and cardiovascular disease. Aim of this study was to investigate the relationship between levels of circulating bone turnover biomarkers and advanced atherosclerosis.
+
+ METHODS: Klotho (KL), sclerostin (SOST), osteopontin (OPN) and osteoprotegerin (OPG) were measured in patients undergoing elective coronary angiography and carotid Doppler ultrasound. The primary outcome was the difference in bone biomarkers levels between participants with and without advanced atherosclerosis, defined as the presence of a critical coronary (>=70%) and/or carotid (>=50%) stenosis.
+
+ RESULTS: A total of 80 subjects (32.5% females) with a mean age of 68 +/- 10 years were included. Advanced atherosclerosis was detected in 55 (68.8%) patients. Subjects with advanced atherosclerosis showed higher serum levels of OPG (p = 0.0015) and SOST (p = 0.017) and similar levels of KL (p = 0.62) and OPN (p = 0.06) compared to patients without. After adjustment for age and sex, only elevated levels of OPG remained significantly associated with advanced atherosclerosis (p = 0.011).
+
+ CONCLUSIONS: Higher serum levels of OPG are independently associated with advanced atherosclerosis confirming a common bond between bone metabolism and vascular disease. Further investigations on the role of selected bone biomarkers in the pathogenesis of cardiovascular disease are needed.
+Registry Number/Name of Substance
+ 0 (Adaptor Proteins, Signal Transducing). 0 (Biomarkers). 0 (Osteoprotegerin). 0 (SOST protein, human). 106441-73-0 (Osteopontin). EC 3-2-1-31 (Glucuronidase). EC 3-2-1-31 (Klotho Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1007%2fs12020-021-02736-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Del+Toro&issn=1355-008X&title=Endocrine&atitle=Association+of+bone+biomarkers+with+advanced+atherosclerotic+disease+in+people+with+overweight%2Fobesity.&volume=73&issue=2&spage=339&epage=346&date=2021&doi=10.1007%2Fs12020-021-02736-8&pmid=33948786&sid=OVID:medline
+
+<869>
+Unique Identifier
+ 33946279
+Title
+ Preventive Effects of Green Tea Extract against Obesity Development in Zebrafish.
+Source
+ Molecules. 26(9), 2021 Apr 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zang L; Shimada Y; Nakayama H; Katsuzaki H; Kim Y; Chu DC; Juneja LR; Kuroyanagi J; Nishimura N
+Author NameID
+ Zang, Liqing; ORCID: https://orcid.org/0000-0001-6936-795X
+ Shimada, Yasuhito; ORCID: https://orcid.org/0000-0002-4111-8262
+ Nakayama, Hiroko; ORCID: https://orcid.org/0000-0001-7335-6428
+ Nishimura, Norihiro; ORCID: https://orcid.org/0000-0001-9866-4013
+Authors Full Name
+ Zang, Liqing; Shimada, Yasuhito; Nakayama, Hiroko; Katsuzaki, Hirotaka; Kim, Youngil; Chu, Djong-Chi; Juneja, Lekh Raj; Kuroyanagi, Junya; Nishimura, Norihiro.
+Institution
+ Zang, Liqing. Graduate School of Regional Innovation Studies, Mie University, Tsu, Mie 514-8507, Japan.
+ Zang, Liqing. Zebrafish Drug Screening Center, Mie University, Tsu, Mie 514-8507, Japan.
+ Shimada, Yasuhito. Zebrafish Drug Screening Center, Mie University, Tsu, Mie 514-8507, Japan.
+ Shimada, Yasuhito. Department of Integrative Pharmacology, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan.
+ Shimada, Yasuhito. Department of Bioinformatics, Advanced Science Research Promotion Center, Mie University, Tsu, Mie 514-8507, Japan.
+ Nakayama, Hiroko. Graduate School of Regional Innovation Studies, Mie University, Tsu, Mie 514-8507, Japan.
+ Nakayama, Hiroko. Zebrafish Drug Screening Center, Mie University, Tsu, Mie 514-8507, Japan.
+ Katsuzaki, Hirotaka. Department of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Mie 514-8507, Japan.
+ Kim, Youngil. Rohto Pharmaceutical Co., Ltd., Osaka 530-0011, Japan.
+ Chu, Djong-Chi. Rohto Pharmaceutical Co., Ltd., Osaka 530-0011, Japan.
+ Juneja, Lekh Raj. Rohto Pharmaceutical Co., Ltd., Osaka 530-0011, Japan.
+ Kuroyanagi, Junya. UMOU Science Lab, Matsusaka, Mie 515-0303, Japan.
+ Nishimura, Norihiro. Graduate School of Regional Innovation Studies, Mie University, Tsu, Mie 514-8507, Japan.
+ Nishimura, Norihiro. Zebrafish Drug Screening Center, Mie University, Tsu, Mie 514-8507, Japan.
+MeSH Subject Headings
+ Adipose Tissue/de [Drug Effects]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Intra-Abdominal Fat/de [Drug Effects]
+ Intra-Abdominal Fat/me [Metabolism]
+ Lipid Metabolism/de [Drug Effects]
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Organ Size/de [Drug Effects]
+ Plant Extracts/ch [Chemistry]
+ *Plant Extracts/pd [Pharmacology]
+ Signal Transduction/de [Drug Effects]
+ *Tea/ch [Chemistry]
+ Zebrafish
+Keyword Heading
+ Mibyo
+ RNA-seq
+ green tea extract
+ obesity
+ visceral adipose tissue
+ zebrafish
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Various natural products (NPs) have been used to treat obesity and related diseases. However, the best way to fight obesity is preventive, with accurate body weight management through exercise, diet, or bioactive NPs to avoid obesity development. We demonstrated that green tea extract (GTE) is an anti-obesity NP using a zebrafish obesity model. Based on a hypothesis that GTE can prevent obesity, the objective of this study was to assess GTE's ability to attenuate obesity development. Juvenile zebrafish were pretreated with GTE for seven days before obesity induction via a high-fat diet; adult zebrafish were pretreated with GTE for two weeks before obesity induction by overfeeding. As a preventive intervention, GTE significantly decreased visceral adipose tissue accumulation in juveniles and ameliorated visceral adiposity and plasma triglyceride levels in adult zebrafish obesity models. RNA sequencing analysis was performed using liver tissues from adult obese zebrafish, with or without GTE administration, to investigate the underlying molecular mechanism. Transcriptome analysis revealed that preventive GTE treatment affects several pathways associated with anti-obesity regulation, including activation of STAT and downregulation of CEBP signaling pathways. In conclusion, GTE could be used as a preventive agent against obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Plant Extracts). 0 (Tea).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fmolecules26092627
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zang&issn=1420-3049&title=Molecules&atitle=Preventive+Effects+of+Green+Tea+Extract+against+Obesity+Development+in+Zebrafish.&volume=26&issue=9&spage=&epage=&date=2021&doi=10.3390%2Fmolecules26092627&pmid=33946279&sid=OVID:medline
+
+<870>
+Unique Identifier
+ 33932464
+Title
+ Blocking endothelial TRPV4-Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice.
+Source
+ Journal of Molecular & Cellular Cardiology. 157:66-76, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gao M; Han J; Zhu Y; Tang C; Liu L; Xiao W; Ma X
+Authors Full Name
+ Gao, Mengru; Han, Jing; Zhu, Yifei; Tang, Chunlei; Liu, Liangliang; Xiao, Wang; Ma, Xin.
+Institution
+ Gao, Mengru. School of Pharmaceutical Sciences, Jiangnan University, Wuxi, China.
+ Han, Jing. School of Medicine, Jiangnan University, Wuxi, China.
+ Zhu, Yifei. School of Medicine, Jiangnan University, Wuxi, China.
+ Tang, Chunlei. School of Pharmaceutical Sciences, Jiangnan University, Wuxi, China.
+ Liu, Liangliang. School of Medicine, Jiangnan University, Wuxi, China.
+ Xiao, Wang. School of Medicine, Jiangnan University, Wuxi, China.
+ Ma, Xin. School of Medicine, Jiangnan University, Wuxi, China; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, China. Electronic address: maxin@jiangnan.edu.cn.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Disease Models, Animal
+ Disease Susceptibility
+ Endothelial Cells/me [Metabolism]
+ *Endothelium, Vascular/me [Metabolism]
+ *Inflammation/et [Etiology]
+ *Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ Inflammation Mediators/me [Metabolism]
+ Mice
+ Mice, Knockout
+ Mice, Obese
+ Mutation
+ NADPH Oxidase 2/ge [Genetics]
+ *NADPH Oxidase 2/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Oxidative Stress
+ Protein Binding/de [Drug Effects]
+ *Reactive Oxygen Species/me [Metabolism]
+ TRPV Cation Channels/ge [Genetics]
+ *TRPV Cation Channels/me [Metabolism]
+ Vasodilation/ge [Genetics]
+Keyword Heading
+ Inflammation
+ Obesity
+ Oxidative stress
+ Treatment
+ Vasodilatory dysfunction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity induces inflammation and oxidative stress, and ultimately leads to vasodilatory dysfunction in which Transient receptor potential vanilloid type 4 (TRPV4) and Nicotinamide Adenine Dinucleotide Phosphate Oxidase (Nox2) have been reported to be involved. However, little attention has been paid to the role of the TRPV4-Nox2 complex in these problems. The purpose of this study was to figure out the role of the TRPV4-Nox2 complex in obesity-induced inflammation, oxidative stress, and vasodilatory dysfunction. Using fluorescence resonance energy transfer and immunoprecipitation assays, we found enhanced TRPV4 and Nox2 interactions in obese mice. Using q-PCR, fluorescent dye dihydroethidium staining, and myotonic techniques, we found that obesity caused inflammation, oxidative stress, and vasodilatory dysfunction. Using adeno-associated viruses, we found that enhancement or attenuation of TRPV4-Nox2 interaction altered the vaso-function. Based on these findings, we found a small-molecule drug, M12, that interrupted the TRPV4-Nox2 interaction, thereby reducing inflammatory factors and reactive oxygen species production and helping to restore the vasodilatory function. In summary, our results revealed a new mechanism by which obesity-induced inflammation, oxidative stress, and vasodilatory dysfunction is caused by enhanced TRPV4-Nox2 interactions. Using M12 to interrupt the TRPV4-Nox2 interaction may have anti-inflammatory and anti-oxidative stress effects and help restore vasodilatory function and thus provide a new therapeutic approach to obesity. Copyright © 2021 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Reactive Oxygen Species). 0 (TRPV Cation Channels). 0 (Trpv4 protein, mouse). EC 1-6-3 (Cybb protein, mouse). EC 1-6-3 (NADPH Oxidase 2).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1016%2fj.yjmcc.2021.04.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gao&issn=0022-2828&title=Journal+of+Molecular+%26+Cellular+Cardiology&atitle=Blocking+endothelial+TRPV4-Nox2+interaction+helps+reduce+ROS+production+and+inflammation%2C+and+improves+vascular+function+in+obese+mice.&volume=157&issue=&spage=66&epage=76&date=2021&doi=10.1016%2Fj.yjmcc.2021.04.008&pmid=33932464&sid=OVID:medline
+
+<871>
+Unique Identifier
+ 33931399
+Title
+ Growth and adrenarche: findings from the CATS observational study.
+Source
+ Archives of Disease in Childhood. 106(10):967-974, 2021 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Goddings AL; Viner RM; Mundy L; Romaniuk H; Molesworth C; Carlin JB; Allen NB; Patton GC
+Author NameID
+ Goddings, Anne-Lise; ORCID: https://orcid.org/0000-0003-4779-8956
+ Viner, Russell M; ORCID: https://orcid.org/0000-0003-3047-2247
+Authors Full Name
+ Goddings, Anne-Lise; Viner, Russell M; Mundy, Lisa; Romaniuk, Helena; Molesworth, Charlotte; Carlin, John B; Allen, Nicholas B; Patton, George C.
+Institution
+ Goddings, Anne-Lise. Population, Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, London, UK anne-lise.goddings@ucl.ac.uk.
+ Viner, Russell M. Population, Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
+ Mundy, Lisa. Centre for Adolescent Health, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
+ Mundy, Lisa. Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
+ Romaniuk, Helena. Biostatistics Unit, Faculty of Health, Deakin University, Burwood, Victoria, Australia.
+ Molesworth, Charlotte. Clinical Epidemiology and Biostatistics Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
+ Carlin, John B. Clinical Epidemiology and Biostatistics Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
+ Carlin, John B. Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
+ Allen, Nicholas B. School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
+ Allen, Nicholas B. Department of Psychology, University of Oregon, Eugene, Oregon, USA.
+ Patton, George C. Centre for Adolescent Health, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
+ Patton, George C. Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
+MeSH Subject Headings
+ *Adrenarche
+ Biomarkers/me [Metabolism]
+ Body Height
+ Body Mass Index
+ *Body Size
+ Body Weight
+ Child
+ Child Development
+ Cross-Sectional Studies
+ *Dehydroepiandrosterone/me [Metabolism]
+ Dehydroepiandrosterone Sulfate/me [Metabolism]
+ Female
+ Humans
+ Male
+ *Obesity/me [Metabolism]
+ *Puberty/me [Metabolism]
+ Saliva/me [Metabolism]
+ *Testosterone/me [Metabolism]
+ Waist Circumference
+Keyword Heading
+ endocrinology
+ growth
+ metabolic
+ nutrition
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: There is increasing evidence that patterns of pubertal maturation are associated with different patterns of health risk. This study aimed to explore the associations between anthropometric measures and salivary androgen concentrations in pre-adolescent children.
+
+ METHODS: We analysed a stratified random sample (N=1151) of pupils aged 8-9 years old from 43 primary schools in Melbourne, Australia from the Childhood to Adolescence Transition Study. Saliva samples were assayed for dehydroepiandrosterone (DHEA), DHEA-sulfate and testosterone. Anthropometric measures included height, weight, body mass index (BMI) and waist circumference. Associations between (1) anthropometric measures and each androgen, and (2) hormone status with obesity and parental report of pubertal development were investigated using linear regression modelling with general estimating equations.
+
+ RESULTS: Greater height, weight, BMI and waist circumference were positively associated with higher androgen concentrations, after adjusting for sex and socioeconomic status. Being overweight or obese was associated with higher testosterone and DHEA concentrations compared with the normal BMI category. Those who were obese were more likely (OR=2.7, 95% CI 1.61 to 4.43, p<0.001) to be in the top tertile of age-adjusted androgen status in both sexes.
+
+ CONCLUSION: This study provides clear evidence for an association between obesity and higher androgen levels in mid-childhood. The adrenal transition may be a critical time period for weight management intervention strategies in order to manage the risk for metabolic problems in later life for high-risk individuals. Copyright © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3XMK78S47O (Testosterone). 459AG36T1B (Dehydroepiandrosterone). 57B09Q7FJR (Dehydroepiandrosterone Sulfate).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1136%2farchdischild-2020-319341
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Goddings&issn=0003-9888&title=Archives+of+Disease+in+Childhood&atitle=Growth+and+adrenarche%3A+findings+from+the+CATS+observational+study.&volume=106&issue=10&spage=967&epage=974&date=2021&doi=10.1136%2Farchdischild-2020-319341&pmid=33931399&sid=OVID:medline
+
+<872>
+Unique Identifier
+ 33929533
+Title
+ Aerobic and resistance exercise improve patient-reported sleep quality and is associated with cardiometabolic biomarkers in Hispanic and non-Hispanic breast cancer survivors who are overweight or obese: results from a secondary analysis.
+Source
+ Sleep. 44(10), 2021 10 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dieli-Conwright CM; Courneya KS; Demark-Wahnefried W; Sami N; Norris MK; Fox FS; Buchanan TA; Spicer D; Bernstein L; Tripathy D
+Author NameID
+ Dieli-Conwright, Christina M; ORCID: https://orcid.org/0000-0001-9093-7259
+ Demark-Wahnefried, Wendy; ORCID: https://orcid.org/0000-0001-5241-932X
+ Bernstein, Leslie; ORCID: https://orcid.org/0000-0002-7692-6518
+Authors Full Name
+ Dieli-Conwright, Christina M; Courneya, Kerry S; Demark-Wahnefried, Wendy; Sami, Nathalie; Norris, Mary K; Fox, Frank S; Buchanan, Thomas A; Spicer, Darcy; Bernstein, Leslie; Tripathy, Debu.
+Institution
+ Dieli-Conwright, Christina M. Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
+ Courneya, Kerry S. Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.
+ Demark-Wahnefried, Wendy. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Sami, Nathalie. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
+ Norris, Mary K. Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
+ Fox, Frank S. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
+ Buchanan, Thomas A. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
+ Spicer, Darcy. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
+ Bernstein, Leslie. Division of Biomarkers of Early Detection and Prevention, Beckman Research Institute, COH, Duarte, CA, USA.
+ Tripathy, Debu. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Breast Neoplasms/co [Complications]
+ Breast Neoplasms/th [Therapy]
+ *Breast Neoplasms
+ *Cancer Survivors
+ *Cardiovascular Diseases
+ Exercise
+ Female
+ Humans
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Overweight/th [Therapy]
+ Patient Reported Outcome Measures
+ Quality of Life
+ *Resistance Training
+ Sleep
+Keyword Heading
+ breast cancer
+ exercise
+ sleep quality
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ STUDY OBJECTIVES: Poor sleep quality affects nearly one-third of breast cancer survivors and is associated with insulin resistance. The purpose of this secondary analysis was to examine the effects of a 16-week exercise intervention on patient-reported sleep quality among breast cancer survivors and assess whether changes in patient-reported sleep quality were associated with cardiometabolic biomarkers. We explored Hispanic ethnicity as a moderator of the effects of exercise on patient-reported sleep quality.
+
+ METHODS: Breast cancer survivors who were overweight or obese were randomized to exercise (n = 50) or usual care (n = 50). The 16-week intervention included aerobic and resistance exercise. Patient-reported sleep quality (Pittsburgh Sleep Quality Index [PSQI]) and biomarkers of cardiometabolic health were assessed at baseline and post-intervention. Within- and between-group differences were assessed using general linear models repeated-measures analyses of variance and mixed-model repeated-measure analysis, respectively. Associations between changes in PSQI and cardiometabolic biomarkers were computed using Pearson correlations. Linear mixed-models were used to evaluate effect modification by ethnicity.
+
+ RESULTS: Participants were 52 +/- 10.4 years old, and over half were of Hispanic ethnicity. As compared to usual care, PSQI global scores improved significantly in the exercise group (mean between-group difference -2.2; 95% CI -3.2 to -0.6). Change in PSQI was inversely associated with changes in all cardiometabolic biomarkers (p < 0.01) among the exercise group. Ethnicity was found to moderate the effects of exercise training on global sleep quality (p < 0.001).
+
+ CONCLUSIONS: An aerobic and resistance exercise intervention effectively improved patient-reported sleep quality in breast cancer survivors. Hispanic ethnicity as a moderator showed greater improvement in patient-reported sleep indicating Hispanic versus non-Hispanic breast cancer survivors may derive larger sleep benefits.
+
+ CLINICAL TRAIL INFORMATION: NCT01140282. Copyright © Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1093%2fsleep%2fzsab111
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dieli-Conwright&issn=0161-8105&title=Sleep&atitle=Aerobic+and+resistance+exercise+improve+patient-reported+sleep+quality+and+is+associated+with+cardiometabolic+biomarkers+in+Hispanic+and+non-Hispanic+breast+cancer+survivors+who+are+overweight+or+obese%3A+results+from+a+secondary+analysis.&volume=44&issue=10&spage=&epage=&date=2021&doi=10.1093%2Fsleep%2Fzsab111&pmid=33929533&sid=OVID:medline
+
+<873>
+Unique Identifier
+ 33924072
+Title
+ Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers. [Review]
+Source
+ International Journal of Molecular Sciences. 22(8), 2021 Apr 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wolodko K; Castillo-Fernandez J; Kelsey G; Galvao A
+Author NameID
+ Wolodko, Karolina; ORCID: https://orcid.org/0000-0003-0634-7331
+ Castillo-Fernandez, Juan; ORCID: https://orcid.org/0000-0002-0034-8029
+ Kelsey, Gavin; ORCID: https://orcid.org/0000-0002-9762-5634
+ Galvao, Antonio; ORCID: https://orcid.org/0000-0002-7990-3071
+Authors Full Name
+ Wolodko, Karolina; Castillo-Fernandez, Juan; Kelsey, Gavin; Galvao, Antonio.
+Institution
+ Wolodko, Karolina. Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of PAS, Tuwima 10, 10-748 Olsztyn, Poland.
+ Castillo-Fernandez, Juan. Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
+ Kelsey, Gavin. Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
+ Kelsey, Gavin. Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK.
+ Galvao, Antonio. Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of PAS, Tuwima 10, 10-748 Olsztyn, Poland.
+ Galvao, Antonio. Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
+ Galvao, Antonio. Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK.
+MeSH Subject Headings
+ Adipokines/me [Metabolism]
+ Animals
+ Biomarkers
+ *Cell Differentiation
+ Female
+ Gene Expression Regulation, Developmental
+ Humans
+ *Leptin/me [Metabolism]
+ Mice
+ Models, Biological
+ Mothers
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Oocytes/cy [Cytology]
+ *Oocytes/me [Metabolism]
+ *Oogenesis
+ Ovarian Follicle/cy [Cytology]
+ *Ovarian Follicle/me [Metabolism]
+ Ovulation
+ Pregnancy
+ *Signal Transduction
+Keyword Heading
+ folliculogenesis
+ leptin
+ obesity
+ oocyte
+ ovary
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22084270
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wolodko&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Revisiting+the+Impact+of+Local+Leptin+Signaling+in+Folliculogenesis+and+Oocyte+Maturation+in+Obese+Mothers.&volume=22&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fijms22084270&pmid=33924072&sid=OVID:medline
+
+<874>
+Unique Identifier
+ 33922576
+Title
+ Dietary Strawberries Improve Cardiometabolic Risks in Adults with Obesity and Elevated Serum LDL Cholesterol in a Randomized Controlled Crossover Trial.
+Source
+ Nutrients. 13(5), 2021 Apr 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Basu A; Izuora K; Betts NM; Kinney JW; Salazar AM; Ebersole JL; Scofield RH
+Author NameID
+ Izuora, Kenneth; ORCID: https://orcid.org/0000-0001-7171-3073
+ Ebersole, Jeffrey L; ORCID: https://orcid.org/0000-0002-9743-6585
+Authors Full Name
+ Basu, Arpita; Izuora, Kenneth; Betts, Nancy M; Kinney, Jefferson W; Salazar, Arnold M; Ebersole, Jeffrey L; Scofield, R Hal.
+Institution
+ Basu, Arpita. Department of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV 89154, USA.
+ Izuora, Kenneth. Section of Endocrinology, School of Medicine, University of Nevada, Las Vegas, NV 89154, USA.
+ Betts, Nancy M. Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
+ Kinney, Jefferson W. Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV 89154, USA.
+ Salazar, Arnold M. Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV 89154, USA.
+ Ebersole, Jeffrey L. School of Dental Medicine, University of Nevada, Las Vegas, NV 89154, USA.
+ Scofield, R Hal. Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
+ Scofield, R Hal. Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ C-Reactive Protein/me [Metabolism]
+ *Cardiometabolic Risk Factors
+ *Cholesterol, LDL/bl [Blood]
+ Cross-Over Studies
+ *Diet
+ Exercise
+ Female
+ *Fragaria/ch [Chemistry]
+ Humans
+ Insulin/bl [Blood]
+ Magnetic Resonance Spectroscopy
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+Keyword Heading
+ LDL cholesterol
+ insulin resistance
+ obesity
+ plasminogen activator inhibitor-1
+ small LDL particles
+ strawberries
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background and aims: Dietary berries, such as strawberries, are rich in bioactive compounds and have been shown to lower cardiometabolic risk. We examined the effects of two dietary achievable doses of strawberries on glycemic control and lipid profiles in obese adults with elevated serum LDL cholesterol (LDL-C). Methods: In this 14-week randomized controlled crossover study, participants were assigned to one of the three arms for four weeks separated by a one-week washout period: control powder, one serving (low dose: 13 g strawberry powder/day), or two-and-a -half servings (high dose: 32 g strawberry powder/day). Participants were instructed to follow their usual diet and lifestyle while refraining from consuming other berries and related products throughout the study interval. Blood samples, anthropometric measures, blood pressure, and dietary and physical activity data were collected at baseline and at the end of each four-week phase of intervention. Results: In total, 33 participants completed all three phases of the trial [(mean +/- SD): Age: 53 +/- 13 y; BMI: 33 +/- 3.0 kg/m2). Findings revealed significant reductions in fasting insulin (p = 0.0002) and homeostatic model of assessment of insulin resistance (p = 0.0003) following the high dose strawberry phase when compared to the low dose strawberry and control phases. Glucose and conventional lipid profiles did not differ among the phases. Nuclear magnetic resonance-determined particle concentrations of total VLDL and chylomicrons, small VLDL, and total and small LDL were significantly decreased after the high dose strawberry phase, compared to control and low dose phases (all p < 0.0001). Among the biomarkers of inflammation and adipokines measured, only serum PAI-1 showed a decrease after the high dose strawberry phase (p = 0.002). Conclusions: These data suggest that consuming strawberries at two-and-a-half servings for four weeks significantly improves insulin resistance, lipid particle profiles, and serum PAI-1 in obese adults with elevated serum LDL-C.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, LDL). 0 (Insulin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13051421
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Basu&issn=2072-6643&title=Nutrients&atitle=Dietary+Strawberries+Improve+Cardiometabolic+Risks+in+Adults+with+Obesity+and+Elevated+Serum+LDL+Cholesterol+in+a+Randomized+Controlled+Crossover+Trial.&volume=13&issue=5&spage=&epage=&date=2021&doi=10.3390%2Fnu13051421&pmid=33922576&sid=OVID:medline
+
+<875>
+Unique Identifier
+ 33920153
+Title
+ The Ability of Exercise to Mitigate Caloric Restriction-Induced Bone Loss in Older Adults: A Structured Review of RCTs and Narrative Review of Exercise-Induced Changes in Bone Biomarkers.
+Source
+ Nutrients. 13(4), 2021 Apr 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wherry SJ; Miller RM; Jeong SH; Beavers KM
+Author NameID
+ Wherry, Sarah J; ORCID: https://orcid.org/0000-0001-8470-8847
+ Jeong, Sarah H; ORCID: https://orcid.org/0000-0003-4014-3260
+Authors Full Name
+ Wherry, Sarah J; Miller, Ryan M; Jeong, Sarah H; Beavers, Kristen M.
+Institution
+ Wherry, Sarah J. Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
+ Wherry, Sarah J. VA Eastern Colorado Geriatric Research, Education, and Clinical Center (GRECC), Aurora, CO 80045, USA.
+ Miller, Ryan M. Department of Internal Medicine, Sections on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
+ Jeong, Sarah H. Z. Smith Reynolds Library, Wake Forest University, Winston-Salem, NC 27109, USA.
+ Beavers, Kristen M. Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Bone Density/ph [Physiology]
+ *Caloric Restriction/ae [Adverse Effects]
+ Combined Modality Therapy/ae [Adverse Effects]
+ Combined Modality Therapy/mt [Methods]
+ *Exercise Therapy/mt [Methods]
+ Humans
+ *Obesity/th [Therapy]
+ Osteoporosis/bl [Blood]
+ *Osteoporosis/ep [Epidemiology]
+ Osteoporosis/et [Etiology]
+ Osteoporosis/pc [Prevention & Control]
+ Osteoporotic Fractures/bl [Blood]
+ *Osteoporotic Fractures/ep [Epidemiology]
+ Osteoporotic Fractures/et [Etiology]
+ Osteoporotic Fractures/pc [Prevention & Control]
+ Randomized Controlled Trials as Topic
+ Risk Factors
+ Treatment Outcome
+ Weight Loss/ph [Physiology]
+Keyword Heading
+ bone loss
+ caloric restriction
+ exercise
+ mechanisms
+ review
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Despite the adverse metabolic and functional consequences of obesity, caloric restriction- (CR) induced weight loss is often contra-indicated in older adults with obesity due to the accompanying loss of areal bone mineral density (aBMD) and subsequent increased risk of fracture. Several studies show a positive effect of exercise on aBMD among weight-stable older adults; however, data on the ability of exercise to mitigate bone loss secondary to CR are surprisingly equivocal. The purpose of this review is to provide a focused update of the randomized controlled trial literature assessing the efficacy of exercise as a countermeasure to CR-induced bone loss among older adults. Secondarily, we present data demonstrating the occurrence of exercise-induced changes in bone biomarkers, offering insight into why exercise is not more effective than observed in mitigating CR-induced bone loss.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fnu13041250
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wherry&issn=2072-6643&title=Nutrients&atitle=The+Ability+of+Exercise+to+Mitigate+Caloric+Restriction-Induced+Bone+Loss+in+Older+Adults%3A+A+Structured+Review+of+RCTs+and+Narrative+Review+of+Exercise-Induced+Changes+in+Bone+Biomarkers.&volume=13&issue=4&spage=&epage=&date=2021&doi=10.3390%2Fnu13041250&pmid=33920153&sid=OVID:medline
+
+<876>
+Unique Identifier
+ 33917992
+Title
+ Medicines for the Treatment of Obesity.
+Source
+ International Journal of Molecular Sciences. 22(8), 2021 Apr 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shin S; Yoon M
+Authors Full Name
+ Shin, Soonshik; Yoon, Michung.
+Institution
+ Shin, Soonshik. Department of Formula Sciences, College of Korean Medicine, Dongeui University, Busan 47227, Korea.
+ Yoon, Michung. Department of Biomedical Engineering, Mokwon University, Daejeon 35349, Korea.
+MeSH Subject Headings
+ Biomarkers
+ Disease Management
+ Disease Susceptibility
+ Drug Discovery
+ Humans
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Obesity/th [Therapy]
+Abstract
+ Obesity is the result of an energy imbalance caused by an increased ratio of caloric intake to energy expenditure [...].
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial. Introductory Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fijms22083866
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shin&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Medicines+for+the+Treatment+of+Obesity.&volume=22&issue=8&spage=&epage=&date=2021&doi=10.3390%2Fijms22083866&pmid=33917992&sid=OVID:medline
+
+<877>
+Unique Identifier
+ 33916292
+Title
+ Assessing the In Vitro Inhibitory Effects on Key Enzymes Linked to Type-2 Diabetes and Obesity and Protein Glycation by Phenolic Compounds of Lauraceae Plant Species Endemic to the Laurisilva Forest.
+Source
+ Molecules. 26(7), 2021 Apr 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Spinola V; Castilho PC
+Author NameID
+ Spinola, Vitor; ORCID: https://orcid.org/0000-0003-2456-8613
+ Castilho, Paula C; ORCID: https://orcid.org/0000-0002-8303-4286
+Authors Full Name
+ Spinola, Vitor; Castilho, Paula C.
+Institution
+ Spinola, Vitor. CQM-Centro de Quimica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.
+ Castilho, Paula C. CQM-Centro de Quimica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.
+MeSH Subject Headings
+ Aldehyde Reductase/ai [Antagonists & Inhibitors]
+ Aldehyde Reductase/ch [Chemistry]
+ Animals
+ *Biomarkers
+ Diabetes Mellitus, Type 2/en [Enzymology]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Forests
+ *Glycoproteins/me [Metabolism]
+ Glycosylation
+ Hypoglycemic Agents/ch [Chemistry]
+ *Hypoglycemic Agents/pd [Pharmacology]
+ *Lauraceae/ch [Chemistry]
+ Metabolic Networks and Pathways
+ Molecular Structure
+ Obesity/en [Enzymology]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Phenols/ch [Chemistry]
+ *Phenols/pd [Pharmacology]
+ Plant Extracts/ch [Chemistry]
+ *Plant Extracts/pd [Pharmacology]
+ Rats
+Keyword Heading
+ Lauraceae
+ aldose reductase inhibition
+ digestive enzymes inhibition
+ polyphenols
+ protein glycation inhibition
+ type-2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Methanolic leaf extracts of four Lauraceae species endemic to Laurisilva forest (Apollonias barbujana, Laurus novocanariensis, Ocotea foetens and Persea indica) were investigated for the first time for their potential to inhibit key enzymes linked to type-2 diabetes (alpha-amylase, alpha-glucosidase, aldose reductase) and obesity (pancreatic lipase), and protein glycation. Lauraceae extracts revealed significant inhibitory activities in all assays, altough with different ability between species. In general, P. indica showed the most promissing results. In the protein glycation assay, all analysed extracts displayed a stronger effect than a reference compound: aminoguanidine (AMG). The in vitro anti-diabetic, anti-obesity and anti-glycation activities of analysed extracts showed correlation with their flavonols and flavan-3-ols (in particular, proanthocyanins) contents. These Lauraceae species have the capacity to assist in adjuvant therapy of type-2 diabetes and associated complications, through modulation of the activity of key metabolic enzymes and prevention of advanced glycation end-products (AGEs) formation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycoproteins). 0 (Hypoglycemic Agents). 0 (Phenols). 0 (Plant Extracts). EC 1-1-1-21 (Aldehyde Reductase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.3390%2fmolecules26072023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Spinola&issn=1420-3049&title=Molecules&atitle=Assessing+the+In+Vitro+Inhibitory+Effects+on+Key+Enzymes+Linked+to+Type-2+Diabetes+and+Obesity+and+Protein+Glycation+by+Phenolic+Compounds+of+Lauraceae+Plant+Species+Endemic+to+the+Laurisilva+Forest.&volume=26&issue=7&spage=&epage=&date=2021&doi=10.3390%2Fmolecules26072023&pmid=33916292&sid=OVID:medline
+
+<878>
+Unique Identifier
+ 33887128
+Title
+ The effects of pre-pregnancy obesity and gestational weight gain on maternal lipid profiles, fatty acids and insulin resistance.
+Source
+ Journal of Perinatal Medicine. 49(7):873-883, 2021 Sep 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gulecoglu Onem MG; Coker C; Baysal K; Altunyurt S; Keskinoglu P
+Author NameID
+ Gulecoglu Onem, Muge Gul; ORCID: https://orcid.org/0000-0001-8156-1544
+Authors Full Name
+ Gulecoglu Onem, Muge Gul; Coker, Canan; Baysal, Kemal; Altunyurt, Sabahattin; Keskinoglu, Pembe.
+Institution
+ Gulecoglu Onem, Muge Gul. Department of Medical Biochemistry, Medical Faculty Dokuz Eylul University, Izmir, Turkey.
+ Coker, Canan. Department of Medical Biochemistry, Medical Faculty Dokuz Eylul University, Izmir, Turkey.
+ Baysal, Kemal. Department of Medical Biochemistry, Medical Faculty Koc University, Istanbul, Turkey.
+ Altunyurt, Sabahattin. Department of Obstetrics and Gynecology, Medical Faculty Dokuz Eylul University, Izmir, Turkey.
+ Keskinoglu, Pembe. Department of Biostatistics and Medical Informatics, Medical Faculty Dokuz Eylul University, Izmir, Turkey.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ *Fatty Acids/bl [Blood]
+ Female
+ *Gestational Weight Gain/ph [Physiology]
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ Linear Models
+ *Lipids/bl [Blood]
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Pregnancy
+ Pregnancy Complications/bl [Blood]
+ *Pregnancy Complications/pp [Physiopathology]
+ Pregnancy Trimester, First/bl [Blood]
+ Pregnancy Trimester, First/ph [Physiology]
+ Pregnancy Trimester, Second/bl [Blood]
+ *Pregnancy Trimester, Second/ph [Physiology]
+ Young Adult
+Keyword Heading
+ fatty acids
+ gestational weight gain
+ insulin resistance
+ lipid profile
+ obesity
+ pregestational body mass index
+ pregnancy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Pregnancy is associated with physiological alterations in insulin sensitivity and lipid metabolism. This study investigates the associations between pregestational body mass index (pBMI) and the rate of gestational weight gain (rGWG) in the second trimester with the biomarkers of lipid, fatty acids metabolism and insulin resistance.
+
+ METHODS: Sixty nine pregnant women followed. The body weights of the pregnant women were measured and blood samples were obtained at 11-14th and 24-28th weeks of pregnancy. Glucose, total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, insulin levels and fatty acids were measured. Rate of GWG (kg/week) and The Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) were calculated. The pregnant women were stratified according to their pBMI and the 2nd trimester rGWG.
+
+ RESULTS: The rate of GWG was significantly higher for the group with pBMI<25, compared to the group with pBMI>=25 (p=0.024). Triglyceride, total cholesterol, LDL and HDL cholesterol were significantly increased in the second trimester compared with the first trimester. Palmitic acid, oleic acid, linoleic acid, myristic acid, docosahexaenoic acid (DHA), arachidonic acid (AA), total omega-6 (n - 6) and omega-3 (n - 3) fatty acid levels and n - 6/n - 3 ratio were significantly higher in the second trimester. Glucose was significantly decreased and insulin was increased in the second trimester. In the overweight/obese group; HOMA-IR, insulin, AA, palmitoleic acid and stearic acid were found to be high in comparison to the group with low/normal pBMI. No parameters were associated with rGWG.
+
+ CONCLUSIONS: The changes in lipid parameters, free fatty acids, insulin and HOMA-IR in the second trimester were compatible with the changes in lipid metabolism and the development of insulin resistance. Pregestational BMI was shown to have a stronger influence on lipid profile, insulin resistance, and fatty acids than rGWG. Copyright © 2021 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1515%2fjpm-2020-0540
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gulecoglu+Onem&issn=0300-5577&title=Journal+of+Perinatal+Medicine&atitle=The+effects+of+pre-pregnancy+obesity+and+gestational+weight+gain+on+maternal+lipid+profiles%2C+fatty+acids+and+insulin+resistance.&volume=49&issue=7&spage=873&epage=883&date=2021&doi=10.1515%2Fjpm-2020-0540&pmid=33887128&sid=OVID:medline
+
+<879>
+Unique Identifier
+ 33886608
+Title
+ Complex effects of whole body cryostimulation on hematological markers in patients with obesity.
+Source
+ PLoS ONE [Electronic Resource]. 16(4):e0249812, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wyrostek J; Piotrowska A; Czerwinska-Ledwig O; Zuziak R; Szygula Z; Cison T; Zychowska M; Pilch W
+Author NameID
+ Wyrostek, Joanna; ORCID: https://orcid.org/0000-0002-9293-9941
+Authors Full Name
+ Wyrostek, Joanna; Piotrowska, Anna; Czerwinska-Ledwig, Olga; Zuziak, Roxana; Szygula, Zbigniew; Cison, Tomasz; Zychowska, Malgorzata; Pilch, Wanda.
+Institution
+ Wyrostek, Joanna. Faculty of Physiotherapy, University of Physical Education in Krakow, Krakow, Poland.
+ Piotrowska, Anna. Institute for Basics Sciences, Faculty of Physiotherapy, University of Physical Education in Krakow, Krakow, Poland.
+ Czerwinska-Ledwig, Olga. Institute for Basics Sciences, Faculty of Physiotherapy, University of Physical Education in Krakow, Krakow, Poland.
+ Zuziak, Roxana. Institute for Basics Sciences, Faculty of Physiotherapy, University of Physical Education in Krakow, Krakow, Poland.
+ Szygula, Zbigniew. Institute of Biomedical Sciences, Department of Sports Medicine and Human Nutrition, University of Physical Education in Krakow, Krakow, Poland.
+ Cison, Tomasz. Department of Physiotherapy, State University of Applied Science in Nowy Sacz, Nowy Sacz, Poland.
+ Zychowska, Malgorzata. Department of Sport, Faculty of Physical Education, Kazimierz Wielki University in Bydgoszcz, Bydgoszcz, Poland.
+ Pilch, Wanda. Institute for Basics Sciences, Faculty of Physiotherapy, University of Physical Education in Krakow, Krakow, Poland.
+MeSH Subject Headings
+ *Adaptation, Physiological/ph [Physiology]
+ Adult
+ Biomarkers/bl [Blood]
+ *Cryotherapy/mt [Methods]
+ Erythrocyte Indices
+ Hematocrit
+ Hematologic Tests/mt [Methods]
+ Humans
+ Male
+ *Obesity/bl [Blood]
+ *Obesity/th [Therapy]
+ Reference Values
+ Young Adult
+Abstract
+ BACKGROUND: Adaptation, including changes in blood properties, to whole-body cryostimulation may depend on many factors, including body mass.
+
+ AIM: This study investigates whether hematological parameters change similarly in a group of people with obesity and a group of men with normal body weight after 10 and 20 cryostimulation treatments.
+
+ METHODS: In our non-randomized trial, the participants were divided into two groups based on their body fat percentage: 14 men with a high (HBF = 29.35%) and 10 with a normal percent of body fat (NBF = 11.40%) and subjected to 20 whole body cryostimulation treatments (-120degreeC for 2-3 minutes). Blood samples were taken before the first and after the 10th and 20th cryostimulation. The following parameters were determined: red blood cells (RBC), hemoglobin concentration (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelets (PLT), red blood cell distribution width (RDW-SD), mean platelet volume (MPV), white blood cells (WBC), neutrophils (NEUT), lymphocytes (LYMPH), monocytes (MONO), eosinophils (EO) and basophiles (BASO).
+
+ RESULTS: Statistically significant differences were found in red blood cells parameters such as RBC, HCT, MCV and MCHC. Time influence was noted for HCT, MCV and MCHC. Two-way ANOVA showed a significant correlation (for time and group) for 2 paramateres: RBC and MCV. For platelet parameters statistically significant differences were found for PLT (group influence) and MPV (time and group interaction). In white blood cells parameters statistically significant differences in levels of LYMPH were noted. Higher levels were observed for HBF group.
+
+ CONCLUSIONS: All observed changes were within the reference range, but hematological markers changed unevenly in people who are obese and non-obese. Therefore, it appears that an amount of fat tissue could be a factor causing the differences in adaptation to low temperature. It is suggested that 20 whole body cryostimulation sessions restore the state of homeostasis disturbed after 10 sessions.
+
+ TRIAL REGISTRATION: ACTRN 12619000524190.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1371%2fjournal.pone.0249812
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wyrostek&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Complex+effects+of+whole+body+cryostimulation+on+hematological+markers+in+patients+with+obesity.&volume=16&issue=4&spage=e0249812&epage=&date=2021&doi=10.1371%2Fjournal.pone.0249812&pmid=33886608&sid=OVID:medline
+
+<880>
+Unique Identifier
+ 33882488
+Title
+ From Obesity to Chronic Kidney Disease: How Can Adipose Tissue Affect Renal Function?. [Review]
+Source
+ Nephron. 145(6):609-613, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Martin-Taboada M; Vila-Bedmar R; Medina-Gomez G
+Authors Full Name
+ Martin-Taboada, Marina; Vila-Bedmar, Rocio; Medina-Gomez, Gema.
+Institution
+ Martin-Taboada, Marina. Departamento de Ciencias Basicas de la Salud, Area de Bioquimica y Biologia Molecular, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain.
+ Vila-Bedmar, Rocio. Departamento de Ciencias Basicas de la Salud, Area de Bioquimica y Biologia Molecular, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain.
+ Medina-Gomez, Gema. Departamento de Ciencias Basicas de la Salud, Area de Bioquimica y Biologia Molecular, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain.
+MeSH Subject Headings
+ *Adipose Tissue/pp [Physiopathology]
+ Biomarkers/me [Metabolism]
+ Humans
+ *Kidney Failure, Chronic/et [Etiology]
+ Kidney Failure, Chronic/me [Metabolism]
+ Kidney Failure, Chronic/pp [Physiopathology]
+ Kidney Failure, Chronic/th [Therapy]
+ MicroRNAs/me [Metabolism]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+Keyword Heading
+ Adipokines
+ Bariatric surgery
+ Chronic kidney disease
+ MicroRNAs
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is directly associated with an increased risk of developing CKD, regardless of other comorbid conditions. Although the molecular mechanisms that link both diseases are not well established, the role of adipose tissue (AT) is becoming increasingly important in obesity-associated kidney damage. In the context of obesity, lipotoxicity and the alteration of AT secretion profile promote inflammation, oxidative stress, and fibrosis in the kidney, which ultimately leads to impaired renal function. Different studies have highlighted the importance of body weight loss in the improvement of renal function markers. In this regard, bariatric surgery, rather than low-calorie diets, has been accepted as the most effective option to lose weight. In fact, a significant reduction in proteinuria and hyperfiltration has been observed in association with surgically induced weight loss. Detection of early signs of kidney dysfunction in patients with obesity has not been accomplished yet, though. Therefore, understanding the harmful effects within the adipo-renal axis is essential to prevent the progression to the irreversible renal insufficiency. MicroRNAs have recently been described as important modulators of normal kidney function. Some of these microRNAs could be potential early markers of kidney damage, which would help with the diagnosis and the prevention of CKD. Copyright © 2021 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1159%2f000515418
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Martin-Taboada&issn=1660-8151&title=Nephron&atitle=From+Obesity+to+Chronic+Kidney+Disease%3A+How+Can+Adipose+Tissue+Affect+Renal+Function%3F.&volume=145&issue=6&spage=609&epage=613&date=2021&doi=10.1159%2F000515418&pmid=33882488&sid=OVID:medline
+
+<881>
+Unique Identifier
+ 33880941
+Title
+ Arterial Platelet Adhesion in Atherosclerosis-Prone Arteries of Obese, Insulin-Resistant Nonhuman Primates.
+Source
+ Journal of the American Heart Association. 10(9):e019413, 2021 05 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Brown E; Ozawa K; Moccetti F; Vinson A; Hodovan J; Nguyen TA; Bader L; Lopez JA; Kievit P; Shaw GD; Chung DW; Osborn W; Fu X; Chen J; Lindner JR
+Authors Full Name
+ Brown, Eran; Ozawa, Koya; Moccetti, Federico; Vinson, Amanda; Hodovan, James; Nguyen, The Anh; Bader, Lindsay; Lopez, Jose A; Kievit, Paul; Shaw, Gray D; Chung, Dominic W; Osborn, Warren; Fu, Xiaoyun; Chen, Junmei; Lindner, Jonathan R.
+Institution
+ Brown, Eran. Knight Cardiovascular Institute Portland OR.
+ Ozawa, Koya. Knight Cardiovascular Institute Portland OR.
+ Moccetti, Federico. Knight Cardiovascular Institute Portland OR.
+ Vinson, Amanda. Oregon National Primate Research CenterOregon Health & Science University Portland OR.
+ Hodovan, James. Knight Cardiovascular Institute Portland OR.
+ Nguyen, The Anh. Knight Cardiovascular Institute Portland OR.
+ Bader, Lindsay. Oregon National Primate Research CenterOregon Health & Science University Portland OR.
+ Lopez, Jose A. Bloodworks Research Institute Seattle WA.
+ Kievit, Paul. Oregon National Primate Research CenterOregon Health & Science University Portland OR.
+ Shaw, Gray D. Quell Pharma Inc. Plymouth MA.
+ Chung, Dominic W. Bloodworks Research Institute Seattle WA.
+ Osborn, Warren. Bloodworks Research Institute Seattle WA.
+ Fu, Xiaoyun. Bloodworks Research Institute Seattle WA.
+ Chen, Junmei. Bloodworks Research Institute Seattle WA.
+ Lindner, Jonathan R. Knight Cardiovascular Institute Portland OR.
+ Lindner, Jonathan R. Oregon National Primate Research CenterOregon Health & Science University Portland OR.
+MeSH Subject Headings
+ Animals
+ *Atherosclerosis/me [Metabolism]
+ Atherosclerosis/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ *Blood Platelets/me [Metabolism]
+ *Carotid Arteries/me [Metabolism]
+ Carotid Arteries/pa [Pathology]
+ Carotid Arteries/pp [Physiopathology]
+ Carotid Intima-Media Thickness
+ Disease Models, Animal
+ *Endothelium, Vascular/me [Metabolism]
+ Endothelium, Vascular/pa [Pathology]
+ Insulin/me [Metabolism]
+ *Insulin Resistance/ph [Physiology]
+ Macaca mulatta
+ Male
+ Molecular Imaging/mt [Methods]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ *Platelet Adhesiveness/ph [Physiology]
+ Vascular Stiffness/ph [Physiology]
+Keyword Heading
+ atherosclerosis
+ molecular imaging
+ platelets
+ von Willebrand factor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Platelet-endothelial interactions are thought to contribute to early atherogenesis. These interactions are potentiated by oxidative stress. We used in vivo molecular imaging to test the hypothesis that platelet-endothelial interactions occur at early stages of plaque development in obese, insulin-resistant nonhuman primates, and are suppressed by NADPH-oxidase-2 inhibition. Methods and Results Six adult rhesus macaques fed a Western-style diet for a median of 4.0 years were studied at baseline and after 8 weeks of therapy with the NADPH-oxidase-2-inhibitor apocynin (50 mg/kg per day). Six lean control animals were also studied. Measurements included intravenous glucose tolerance test, body composition by dual-energy X-ray absorptiometry, carotid intimal medial thickness, carotid artery contrast ultrasound molecular imaging for platelet GPIbalpha (glycoprotein- Ibalpha) and vascular cell adhesion molecule-1, and blood oxidative markers on mass spectrometry. Compared with lean controls, animals on a Western-style diet were obese (median body mass: 16.0 versus 8.7 kg, P=0.003; median truncal fat: 49% versus 20%, P=0.002), were insulin resistant (4-fold higher insulin-glucose area under the curve on intravenous glucose tolerance test, P=0.002), had 40% larger carotid intimal medial thickness (P=0.004), and exhibited oxidative signatures on proteomics. In obese but not lean animals, signal enhancement on molecular imaging was significantly elevated for GPIbalpha and vascular cell adhesion molecule-1. The signal correlated modestly with intimal medial thickness but not with the degree of insulin resistance. Apocynin significantly (P<0.01) reduced median signal for GPIbalpha by >80% and vascular cell adhesion molecule-1 signal by 75%, but did not affect intimal medial thickness, body mass, or intravenous glucose tolerance test results. Conclusion In nonhuman primates, diet-induced obesity and insulin resistance leads to platelet-endothelial adhesion at early atherosclerotic lesion sites, which is associated with the expression of pro-inflammatory adhesion molecules. These responses appear to be mediated, in part, through oxidative pathways.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med20&DO=10.1161%2fJAHA.120.019413
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Brown&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Arterial+Platelet+Adhesion+in+Atherosclerosis-Prone+Arteries+of+Obese%2C+Insulin-Resistant+Nonhuman+Primates.&volume=10&issue=9&spage=e019413&epage=&date=2021&doi=10.1161%2FJAHA.120.019413&pmid=33880941&sid=OVID:medline
+
+<882>
+Unique Identifier
+ 33868573
+Title
+ The Effects of Combined Physical Exercise on Serum Redox Biomarkers and Leukocyte DNA Damage of Obese Women.
+Source
+ Oxidative medicine & cellular longevity. 2021:6638420, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nascimento C; Peixoto MS; Fonte Boa LF; de Faria CC; Costa TSF; Matta L; Ferreira ACF; Fortunato RS
+Author NameID
+ Matta, Leonardo; ORCID: https://orcid.org/0000-0002-3892-6330
+ Fortunato, Rodrigo Soares; ORCID: https://orcid.org/0000-0003-3497-8173
+Authors Full Name
+ Nascimento, Carla; Peixoto, Milena Simoes; Fonte Boa, Luiz Fernando; de Faria, Caroline Coelho; Costa, Tulio Senna Fonseca; Matta, Leonardo; Ferreira, Andrea Claudia Freitas; Fortunato, Rodrigo Soares.
+Institution
+ Nascimento, Carla. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ Peixoto, Milena Simoes. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ Fonte Boa, Luiz Fernando. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ de Faria, Caroline Coelho. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ Costa, Tulio Senna Fonseca. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ Matta, Leonardo. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ Ferreira, Andrea Claudia Freitas. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ Ferreira, Andrea Claudia Freitas. NUMPEX, Campus Duque de Caxias, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ Fortunato, Rodrigo Soares. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/me [Metabolism]
+ *DNA Damage/ge [Genetics]
+ *Exercise/ph [Physiology]
+ Female
+ Humans
+ *Leukocytes/me [Metabolism]
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/th [Therapy]
+ Oxidation-Reduction
+Abstract
+ Obesity is usually linked to oxidative stress, which can lead to damage to biomolecules. The combination of aerobic and strength exercises seems to induce health benefits in obese individuals, but little is known about the effects of combined physical exercise on redox homeostasis and DNA damage in this population. Thus, the aim of the current study was to determine the effects of 16 weeks of combined physical exercise on biomarkers of oxidative stress and DNA damage in obese women. 17 obese women underwent 16 weeks of a combined physical training program, 3 times per week. Anthropometric and biochemical parameters, serum superoxide dismutase (SOD) and glutathione peroxidase activity, plasma 8-isoprostane levels, and DNA and chromosomal damage were evaluated before and after physical training. Combined physical exercise training decreased body weight (83.2 +/- 9.6 vs. 80.2 +/- 9.6 kg), body mass index (33.8 +/- 3.6 vs. 32.6 +/- 3.7 kg.m-2), body fat (40.2 +/- 2.6 vs. 39.0 +/- 3.2%), and waist circumference (99.3 +/- 9.4 vs. 94.1 +/- 8.8 cm), while the fat-free mass was augmented (59.9 +/- 2.9 vs. 60.7 +/- 3.1 kg). Moreover, blood glucose reduced (113.5 +/- 29.6 vs. 107.3 +/- 28.9 mg/dL) along with high-density lipoprotein (54.6 +/- 18.1 vs. 59.0 +/- 18.8 mg/dL), TSH (2.1 +/- 1.1 vs. 2.6 +/- 1.2 mIU/mL), and free T4 (0.9 +/- 0.1 vs. 1.12 +/- 0.2 ng/dL) increase after physical exercise training. Plasma 8-isoprostane levels (17.24 +/- 7.9 vs. 29.11 +/- 17.44 pg/mL) and DNA damage (34.16 +/- 7.1 vs. 45.96 +/- 5.8% DNA in tail) were also higher after physical training. No changes were observed in chromosomal damage levels. These results suggest that 16 weeks of combined exercise training 3 times per week is effective in reducing body fat but also increases oxidative stress and DNA damage in obese women. Copyright © 2021 Carla Nascimento et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1155%2f2021%2f6638420
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nascimento&issn=1942-0994&title=Oxidative+medicine+%26+cellular+longevity&atitle=The+Effects+of+Combined+Physical+Exercise+on+Serum+Redox+Biomarkers+and+Leukocyte+DNA+Damage+of+Obese+Women.&volume=2021&issue=&spage=6638420&epage=&date=2021&doi=10.1155%2F2021%2F6638420&pmid=33868573&sid=OVID:medline
+
+<883>
+Unique Identifier
+ 33301815
+Title
+ Oxidative stress and neuroinflammation in a rat model of co-morbid obesity and psychogenic stress.
+Source
+ Behavioural Brain Research. 400:112995, 2021 02 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Santiago Santana JM; Vega-Torres JD; Ontiveros-Angel P; Bin Lee J; Arroyo Torres Y; Cruz Gonzalez AY; Aponte Boria E; Zabala Ortiz D; Alvarez Carmona C; Figueroa JD
+Authors Full Name
+ Santiago Santana, Jose M; Vega-Torres, Julio D; Ontiveros-Angel, Perla; Bin Lee, Jeong; Arroyo Torres, Yaria; Cruz Gonzalez, Alondra Y; Aponte Boria, Esther; Zabala Ortiz, Deisha; Alvarez Carmona, Carolina; Figueroa, Johnny D.
+Institution
+ Santiago Santana, Jose M. Neuroregeneration Division, Neuroscience Research Laboratory, Natural Sciences Department, University of Puerto Rico Carolina Campus, Puerto Rico.
+ Vega-Torres, Julio D. Center for Health Disparities and Molecular Medicine and Department of Basic Sciences, Physiology Division, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States.
+ Ontiveros-Angel, Perla. Center for Health Disparities and Molecular Medicine and Department of Basic Sciences, Physiology Division, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States.
+ Bin Lee, Jeong. Center for Health Disparities and Molecular Medicine and Department of Basic Sciences, Physiology Division, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States.
+ Arroyo Torres, Yaria. Neuroregeneration Division, Neuroscience Research Laboratory, Natural Sciences Department, University of Puerto Rico Carolina Campus, Puerto Rico; Universidad Metropolitana de Cupey Sciences and Technology School, Puerto Rico.
+ Cruz Gonzalez, Alondra Y. Neuroregeneration Division, Neuroscience Research Laboratory, Natural Sciences Department, University of Puerto Rico Carolina Campus, Puerto Rico.
+ Aponte Boria, Esther. Neuroregeneration Division, Neuroscience Research Laboratory, Natural Sciences Department, University of Puerto Rico Carolina Campus, Puerto Rico.
+ Zabala Ortiz, Deisha. Neuroregeneration Division, Neuroscience Research Laboratory, Natural Sciences Department, University of Puerto Rico Carolina Campus, Puerto Rico.
+ Alvarez Carmona, Carolina. Neuroregeneration Division, Neuroscience Research Laboratory, Natural Sciences Department, University of Puerto Rico Carolina Campus, Puerto Rico.
+ Figueroa, Johnny D. Center for Health Disparities and Molecular Medicine and Department of Basic Sciences, Physiology Division, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States. Electronic address: jfigueroa@llu.edu.
+MeSH Subject Headings
+ Animals
+ *Anxiety/me [Metabolism]
+ *Anxiety/pp [Physiopathology]
+ *Behavior, Animal/ph [Physiology]
+ Biomarkers/me [Metabolism]
+ Catalase/me [Metabolism]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ *Fear/ph [Physiology]
+ Glial Fibrillary Acidic Protein/me [Metabolism]
+ Glutathione Peroxidase/bl [Blood]
+ Glutathione Reductase/bl [Blood]
+ *Inflammation/me [Metabolism]
+ Male
+ *Obesity/me [Metabolism]
+ *Oxidative Stress/ph [Physiology]
+ Rats
+ Rats, Inbred Lew
+ *Reactive Oxygen Species/me [Metabolism]
+ *Stress, Psychological/me [Metabolism]
+ *Stress, Psychological/pp [Physiopathology]
+Keyword Heading
+ Diet-induced obesity rat
+ Neuroinflammation
+ PTSD
+ Reactive oxygen species
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: There is growing recognition for a reciprocal, bidirectional link between anxiety disorders and obesity. Although the mechanisms linking obesity and anxiety remain speculative, this bidirectionality suggests shared pathophysiological processes. Neuroinflammation and oxidative damage are implicated in both pathological anxiety and obesity. This study investigates the relative contribution of comorbid diet-induced obesity and stress-induced anxiety to neuroinflammation and oxidative stress.
+
+ METHODS: Thirty-six (36) male Lewis rats were divided into four groups based on diet type and stress exposure: 1) control diet unexposed (CDU) and 2) exposed (CDE), 3) Western-like high-saturated fat diet unexposed (WDU) and 4) exposed (WDE). Neurobehavioral tests were performed to assess anxiety-like behaviors. The catalytic concentrations of glutathione peroxidase and reductase were measured from plasma samples, and neuroinflammatory/oxidative stress biomarkers were measured from brain samples using Western blot. Correlations between behavioral phenotypes and biomarkers were assessed with Pearson's correlation procedures.
+
+ RESULTS: We found that WDE rats exhibited markedly increased levels of glial fibrillary acidic protein (185 %), catalase protein (215 %), and glutathione reductase (GSHR) enzymatic activity (418 %) relative to CDU rats. Interestingly, the brain protein levels of glutathione peroxidase (GPx) and catalase were positively associated with body weight and behavioral indices of anxiety.
+
+ CONCLUSIONS: Together, our results support a role for neuroinflammation and oxidative stress in heightened emotional reactivity to obesogenic environments and psychogenic stress. Uncovering adaptive responses to obesogenic environments characterized by high access to high-saturated fat/high-sugar diets and toxic stress has the potential to strongly impact how we treat psychiatric disorders in at-risk populations. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (GFAP protein, rat). 0 (Glial Fibrillary Acidic Protein). 0 (Reactive Oxygen Species). EC 1-11-1-6 (Catalase). EC 1-11-1-9 (Glutathione Peroxidase). EC 1-8-1-7 (Glutathione Reductase).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.bbr.2020.112995
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Santiago+Santana&issn=0166-4328&title=Behavioural+Brain+Research&atitle=Oxidative+stress+and+neuroinflammation+in+a+rat+model+of+co-morbid+obesity+and+psychogenic+stress.&volume=400&issue=&spage=112995&epage=&date=2021&doi=10.1016%2Fj.bbr.2020.112995&pmid=33301815&sid=OVID:medline
+
+<884>
+Unique Identifier
+ 33068491
+Title
+ Potential biomarker in serum for predicting susceptibility to type 2 diabetes mellitus: Free fatty acid 22:6.
+Source
+ Journal of Diabetes Investigation. 12(6):950-962, 2021 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ma Y; Xiong J; Zhang X; Qiu T; Pang H; Li X; Zhu J; Wang J; Pan C; Yang X; Chu X; Yang B; Wang C; Zhang J
+Author NameID
+ Zhang, Jun; ORCID: https://orcid.org/0000-0002-4321-8080
+Authors Full Name
+ Ma, Yinghua; Xiong, Jianyu; Zhang, Xueting; Qiu, Tongtong; Pang, Huai; Li, Xue; Zhu, Jiaojiao; Wang, Jingzhou; Pan, Chongge; Yang, Xin; Chu, Xiaolong; Yang, Bingqi; Wang, Cuizhe; Zhang, Jun.
+Institution
+ Ma, Yinghua. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Xiong, Jianyu. Department of Genetics, Shihezi University School of Medicine, Shihezi, China.
+ Zhang, Xueting. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Qiu, Tongtong. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Pang, Huai. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Li, Xue. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Zhu, Jiaojiao. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Wang, Jingzhou. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Pan, Chongge. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Yang, Xin. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Chu, Xiaolong. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Yang, Bingqi. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Wang, Cuizhe. Department of Biochemistry and Molecular Biology, Shihezi University School of Medicine, Shihezi, China.
+ Zhang, Jun. Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi, China.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ *Disease Susceptibility/bl [Blood]
+ *Fatty Acids, Nonesterified/bl [Blood]
+ Female
+ Gas Chromatography-Mass Spectrometry
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Predictive Value of Tests
+ Risk Factors
+Keyword Heading
+ C22:6
+ Obesity
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: Type 2 diabetes mellitus is closely linked to increased levels of free fatty acids (FFAs) in obese individuals, although which FFA is most associated with type 2 diabetes mellitus is unclear. This study aimed to identify the specific FFAs that best predict the occurrence of type 2 diabetes mellitus in obese individuals, and assess their potential application value.
+
+ MATERIALS AND METHODS: Participants were divided into three groups: a normal weight group (n = 20), an obese group (n = 10) and a type 2 diabetes mellitus group (n = 10). FFAs in serum samples were determined by ultra-high-pressure liquid chromatography-mass spectrometry, and orthogonal partial least squares discriminant analysis models were used to study the FFA profile among the three groups.
+
+ RESULTS: Compared with the normal weight group, 14 FFAs (C8:0/10:0/14:0/16:1/18:1/20:2/ 20:3 /20:4/ 20:5/ 22:6/7:0/9:0/11:0 and C13:0) were significantly increased in the obese group, and nine FFAs (C14:0, C18:1, C20:1, C 18:2, C20:2, C20:3, C18:3, C20:5 and C22:6) were significantly increased in the type 2 diabetes mellitus group. Subsequently, the Venn diagram results showed that six FFAs (C14:0, C18:1, C20:2, C20:3, C20:5 and C22:6) were significantly increased in both the obese and type 2 diabetes mellitus groups. Among these six, C22:6 was finally identified as an independent risk factor for type 2 diabetes mellitus, and had a great potential to predict the susceptibility to type 2 diabetes mellitus (area under the curve 0.803).
+
+ CONCLUSIONS: C22:6 can be an independent risk factor for type 2 diabetes mellitus, and it has a great potential to predict the susceptibility to type 2 diabetes mellitus. Copyright © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Nonesterified).
+Publication Type
+ Evaluation Study. Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fjdi.13443
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ma&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Potential+biomarker+in+serum+for+predicting+susceptibility+to+type+2+diabetes+mellitus%3A+Free+fatty+acid+22%3A6.&volume=12&issue=6&spage=950&epage=962&date=2021&doi=10.1111%2Fjdi.13443&pmid=33068491&sid=OVID:medline
+
+<885>
+Unique Identifier
+ 33063457
+Title
+ Serum C-X-C motif chemokine ligand 14 levels are associated with serum C-peptide and fatty liver index in type 2 diabetes mellitus patients.
+Source
+ Journal of Diabetes Investigation. 12(6):1042-1049, 2021 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Matsushita Y; Hasegawa Y; Takebe N; Onodera K; Shozushima M; Oda T; Nagasawa K; Honma H; Nata K; Sasaki A; Ishigaki Y
+Author NameID
+ Ishigaki, Yasushi; ORCID: https://orcid.org/0000-0003-2479-5752
+Authors Full Name
+ Matsushita, Yuriko; Hasegawa, Yutaka; Takebe, Noriko; Onodera, Ken; Shozushima, Masaharu; Oda, Tomoyasu; Nagasawa, Kan; Honma, Hiroyuki; Nata, Koji; Sasaki, Akira; Ishigaki, Yasushi.
+Institution
+ Matsushita, Yuriko. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+ Hasegawa, Yutaka. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+ Takebe, Noriko. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+ Onodera, Ken. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+ Shozushima, Masaharu. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+ Oda, Tomoyasu. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+ Nagasawa, Kan. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+ Honma, Hiroyuki. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+ Nata, Koji. Division of Medical Biochemistry, School of Pharmacy, Iwate Medical University, Yahaba, Japan.
+ Sasaki, Akira. Department of Surgery, Iwate Medical University, Yahaba, Japan.
+ Ishigaki, Yasushi. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Age Factors
+ Aged
+ Alanine Transaminase/bl [Blood]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *C-Peptide/bl [Blood]
+ *Chemokines, CXC/bl [Blood]
+ Cholesterol/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Fatty Liver/bl [Blood]
+ Fatty Liver/ge [Genetics]
+ Female
+ Humans
+ *Insulin Resistance/ge [Genetics]
+ Intra-Abdominal Fat
+ Linear Models
+ Lipoproteins, LDL/bl [Blood]
+ Liver Function Tests
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Pulse Wave Analysis
+ Triglycerides/bl [Blood]
+ Uric Acid/bl [Blood]
+ Waist Circumference/ge [Genetics]
+Keyword Heading
+ C-X-C motif chemokine ligand 14
+ Hepatic steatosis
+ Insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: Recent studies have suggested C-X-C motif chemokine ligand 14 (CXCL14), secreted from adipose tissue, to play an important role in the pathogenesis of metabolic syndrome. However, the clinical significance of CXCL14 in humans has not been elucidated. This study aimed to assess correlations between serum CXCL14 levels and clinical parameters in patients with type 2 diabetes mellitus.
+
+ MATERIALS AND METHODS: In total, 176 individuals with type 2 diabetes mellitus were recruited. Serum CXCL14 concentrations were determined by enzyme-linked immunosorbent assay. We examined the associations of serum CXCL14 levels with laboratory values, abdominal computed tomography image information, surrogate markers used for evaluating the pathological states of diabetes, obesity and atherosclerosis.
+
+ RESULTS: Serum CXCL14 levels correlated positively with body mass index, waist circumference, subcutaneous and visceral fat areas, and serum alanine transaminase, uric acid, total cholesterol, low-density lipoprotein cholesterol, triglycerides and C-peptide (CPR) levels. In contrast, CXCL14 levels correlated inversely with age, pulse wave velocity and serum adiponectin levels. Multiple linear regression analysis showed serum levels of CPR (beta = 0.227, P = 0.038) and the fatty liver index (beta = 0.205, P = 0.049) to be the only parameters showing independent statistically significant associations with serum CXCL14 levels.
+
+ CONCLUSIONS: Serum CXCL14 levels were independently associated with serum CPR and fatty liver index in patients with type 2 diabetes mellitus. In these patients, a high serum CPR concentration might reflect insulin resistance rather than beta-cell function, because CXCL14 showed simple correlations with obesity-related parameters. Collectively, these data suggested that serum CXCL14 levels in type 2 diabetes patients might be useful predictors of elevated serum CPR and hepatic steatosis. Copyright © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (C-Peptide). 0 (CXCL14 protein, human). 0 (Chemokines, CXC). 0 (Lipoproteins, LDL). 0 (Triglycerides). 268B43MJ25 (Uric Acid). 97C5T2UQ7J (Cholesterol). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fjdi.13438
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Matsushita&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Serum+C-X-C+motif+chemokine+ligand+14+levels+are+associated+with+serum+C-peptide+and+fatty+liver+index+in+type+2+diabetes+mellitus+patients.&volume=12&issue=6&spage=1042&epage=1049&date=2021&doi=10.1111%2Fjdi.13438&pmid=33063457&sid=OVID:medline
+
+<886>
+Unique Identifier
+ 33806905
+Title
+ Nanoproteomic Approach for Isolation and Identification of Potential Biomarkers in Human Urine from Adults with Normal Weight, Overweight and Obesity.
+Source
+ Molecules. 26(6), 2021 Mar 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hernandez-Leon SG; Sarabia Sainz JA; Ramos-Clamont Montfort G; Huerta-Ocampo JA; Ballesteros MN; Guzman-Partida AM; Robles-Burgueno MDR; Vazquez-Moreno L
+Author NameID
+ Hernandez-Leon, Sergio G; ORCID: https://orcid.org/0000-0002-1543-8262
+ Sarabia Sainz, Jose Andre-I; ORCID: https://orcid.org/0000-0003-0800-4754
+ Ramos-Clamont Montfort, Gabriela; ORCID: https://orcid.org/0000-0001-8685-6421
+ Huerta-Ocampo, Jose Angel; ORCID: https://orcid.org/0000-0003-4505-841X
+ Guzman-Partida, Ana M; ORCID: https://orcid.org/0000-0003-0481-8689
+Authors Full Name
+ Hernandez-Leon, Sergio G; Sarabia Sainz, Jose Andre-I; Ramos-Clamont Montfort, Gabriela; Huerta-Ocampo, Jose Angel; Ballesteros, Martha Nydia; Guzman-Partida, Ana M; Robles-Burgueno, Maria Del Refugio; Vazquez-Moreno, Luz.
+Institution
+ Hernandez-Leon, Sergio G. Centro de Investigacion en Alimentacion y Desarrollo A.C., Carretera Gustavo Enrique Astiazaran Rosas, No. 46, col. La Victoria, Hermosillo, Sonora 83304, Mexico.
+ Sarabia Sainz, Jose Andre-I. Departamento de Investigacion en Fisica, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Col. Centro, Hermosillo, Sonora 83190, Mexico.
+ Ramos-Clamont Montfort, Gabriela. Centro de Investigacion en Alimentacion y Desarrollo A.C., Carretera Gustavo Enrique Astiazaran Rosas, No. 46, col. La Victoria, Hermosillo, Sonora 83304, Mexico.
+ Huerta-Ocampo, Jose Angel. CONACyT-Centro de Investigacion en Alimentacion y Desarrollo A.C., Carretera Gustavo Enrique Astiazaran Rosas, No. 46, col. La Victoria, Hermosillo, Sonora 83304, Mexico.
+ Ballesteros, Martha Nydia. Centro de Investigacion en Alimentacion y Desarrollo A.C., Carretera Gustavo Enrique Astiazaran Rosas, No. 46, col. La Victoria, Hermosillo, Sonora 83304, Mexico.
+ Guzman-Partida, Ana M. Centro de Investigacion en Alimentacion y Desarrollo A.C., Carretera Gustavo Enrique Astiazaran Rosas, No. 46, col. La Victoria, Hermosillo, Sonora 83304, Mexico.
+ Robles-Burgueno, Maria Del Refugio. Centro de Investigacion en Alimentacion y Desarrollo A.C., Carretera Gustavo Enrique Astiazaran Rosas, No. 46, col. La Victoria, Hermosillo, Sonora 83304, Mexico.
+ Vazquez-Moreno, Luz. Centro de Investigacion en Alimentacion y Desarrollo A.C., Carretera Gustavo Enrique Astiazaran Rosas, No. 46, col. La Victoria, Hermosillo, Sonora 83304, Mexico.
+MeSH Subject Headings
+ Adult
+ Biomarkers/ur [Urine]
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/ur [Urine]
+ *Proteinuria/ur [Urine]
+ *Proteomics
+Keyword Heading
+ Cibacron blue
+ FCSNP
+ HMW proteins
+ LMW proteins
+ nanoproteomics
+ urinary biomarkers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In this work, previously synthesized and characterized core-shell silica nanoparticles (FCSNP) functionalized with immobilized molecular bait, Cibacron blue, and a porous polymeric bis-acrylamide shell were incubated with pooled urine samples from adult women or men with normal weight, overweight or obesity for the isolation of potential biomarkers. A total of 30 individuals (15 woman and 15 men) were included. FCSNP allowed the capture of a variety of low molecular weight (LMW) proteins as evidenced by mass spectrometry (MS) and the exclusion of high molecular weight (HMW) proteins (>34 kDa) as demonstrated by SDS-PAGE and 2D SDS-PAGE. A total of 36 proteins were successfully identified by MS and homology database searching against the Homo sapiens subset of the Swiss-Prot database. Identified proteins were grouped into different clusters according to their abundance patterns. Four proteins were found only in women and five only in men, whereas 27 proteins were in urine from both genders with different abundance patterns. Based on these results, this new approach represents an alternative tool for isolation and identification of urinary biomarkers.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fmolecules26061803
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hernandez-Leon&issn=1420-3049&title=Molecules&atitle=Nanoproteomic+Approach+for+Isolation+and+Identification+of+Potential+Biomarkers+in+Human+Urine+from+Adults+with+Normal+Weight%2C+Overweight+and+Obesity.&volume=26&issue=6&spage=&epage=&date=2021&doi=10.3390%2Fmolecules26061803&pmid=33806905&sid=OVID:medline
+
+<887>
+Unique Identifier
+ 33758311
+Title
+ Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population.
+Source
+ Scientific Reports. 11(1):6640, 2021 03 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ali N; Sumon AH; Fariha KA; Asaduzzaman M; Kathak RR; Molla NH; Mou AD; Barman Z; Hasan M; Miah R; Islam F
+Author NameID
+ Ali, Nurshad; ORCID: https://orcid.org/0000-0003-1649-0887
+ Islam, Farjana; ORCID: https://orcid.org/0000-0001-8274-2021
+Authors Full Name
+ Ali, Nurshad; Sumon, Abu Hasan; Fariha, Khandaker Atkia; Asaduzzaman, Md; Kathak, Rahanuma Raihanu; Molla, Noyan Hossain; Mou, Ananya Dutta; Barman, Zitu; Hasan, Mahmudul; Miah, Rakib; Islam, Farjana.
+Institution
+ Ali, Nurshad. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh. nur_rubd@yahoo.com.
+ Sumon, Abu Hasan. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Fariha, Khandaker Atkia. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Asaduzzaman, Md. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Kathak, Rahanuma Raihanu. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Molla, Noyan Hossain. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Mou, Ananya Dutta. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Barman, Zitu. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Hasan, Mahmudul. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Miah, Rakib. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+ Islam, Farjana. Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
+MeSH Subject Headings
+ Adult
+ Aspartate Aminotransferases/bl [Blood]
+ Bangladesh/ep [Epidemiology]
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Female
+ Humans
+ *Liver/en [Enzymology]
+ Liver Function Tests
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ *Obesity, Abdominal/bl [Blood]
+ *Obesity, Abdominal/ep [Epidemiology]
+ Population Surveillance
+ Prevalence
+ Urban Population
+ Waist Circumference
+ gamma-Glutamyltransferase/bl [Blood]
+Abstract
+ Obesity is a global health concern because of its increasing trend both in developed and developing countries. A limited number of studies have evaluated the association of liver enzymes with both general and abdominal obesity in the general population; data for the Bangladeshi population are not available yet. This study aimed to assess the relationship of serum liver enzymes activity with both general and abdominal obesity in Bangladeshi adults. In total, 540 blood samples were obtained from the participants (388 males and 152 females) and analyzed for serum levels of ALT, AST, GGT, and ALP using standard methods. General obesity was defined as body mass index (BMI) >= 27.5 kg/m2 and abdominal obesity was defined as waist circumference (WC) >= 90 cm in males and >= 80 cm in females. The relationship between liver enzymes and obesity was evaluated by multivariate logistic regression models. Overall, 58% of participants in the general obesity group and 55% of the participants in the abdominal obesity group had at least one or more elevated levels of liver enzymes. The prevalence of elevated liver enzymes was significantly higher in the obesity group compared to the normal BMI and WC groups (p < 0.05 for all cases). The mean level of serum ALT, AST and GGT were significantly higher in the obesity group than the normal BMI group (p < 0.05). In the WC groups, mean AST and GGT were significantly higher in the obesity group compared to the normal group (p < 0.05). In regression analysis, serum levels of ALT showed an independent and significant association with general obesity, whereas, serum GGT showed a significant association with both general and abdominal obesity. In conclusion, a high prevalence of elevated liver enzymes was observed among participants included in the present study. Of the four enzymes, serum GGT was independently associated with both general and abdominal obesity. Further studies are required to understand the complex relationship between liver enzymes and obesity in the general population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-3-2-2 (gamma-Glutamyltransferase). EC 2-6-1-1 (Aspartate Aminotransferases).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-86216-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ali&issn=2045-2322&title=Scientific+Reports&atitle=Assessment+of+the+relationship+of+serum+liver+enzymes+activity+with+general+and+abdominal+obesity+in+an+urban+Bangladeshi+population.&volume=11&issue=1&spage=6640&epage=&date=2021&doi=10.1038%2Fs41598-021-86216-z&pmid=33758311&sid=OVID:medline
+
+<888>
+Unique Identifier
+ 33532616
+Title
+ Adiponectin, ALT and family history as critical markers for the development of type 2 diabetes in obese Japanese children.
+Source
+ Endocrinology, and Diabetes & Metabolism. 4(1):e00178, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yasuda Y; Miyake N; Matsuoka H; Sugihara S
+Author NameID
+ Sugihara, Shigetaka; ORCID: https://orcid.org/0000-0001-7776-2482
+Authors Full Name
+ Yasuda, Yuki; Miyake, Nobuka; Matsuoka, Hisafumi; Sugihara, Shigetaka.
+Institution
+ Yasuda, Yuki. Department of Pediatrics Tokyo Women's Medical University Medical Center East Tokyo Japan.
+ Miyake, Nobuka. Department of Pediatrics Tokyo Women's Medical University Medical Center East Tokyo Japan.
+ Matsuoka, Hisafumi. Department of Pediatrics Tokyo Women's Medical University Medical Center East Tokyo Japan.
+ Sugihara, Shigetaka. Department of Pediatrics Tokyo Women's Medical University Medical Center East Tokyo Japan.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adolescent
+ Age Factors
+ *Alanine Transaminase/bl [Blood]
+ Asian People
+ *Aspartate Aminotransferases/bl [Blood]
+ Biomarkers
+ Child
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Female
+ Humans
+ Intra-Abdominal Fat
+ Male
+ *Medical History Taking
+ *Obesity/co [Complications]
+ ROC Curve
+Keyword Heading
+ adiponectin
+ metabolic syndrome
+ type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aims/Introduction: An association between the pathogenesis of type 2 diabetes mellitus (T2D) and that of metabolic syndrome (MS) in obese children has been suggested. We clarified the critical markers for the development of T2D in obese Japanese children.
+
+ Methods: One hundred and seven obese children who visited our outpatient clinic were enrolled in this study. The obese subjects were divided into 3 groups: Group A, T2D (n = 19); Group B, MS but not T2D (n = 19); and Group C: non-T2D, non-MS (n = 69). In all the subjects, a biochemical examination was performed and the serum adiponectin and leptin levels were measured. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured using computed tomography images.
+
+ Results: Group A tended to have higher VAT values and VAT/SAT ratios and lower leptin and adiponectin levels, compared with Groups B and C. In Group A, the alanine aminotransferase (ALT) level was significantly higher and the aspartate aminotransferase (AST)/ALT ratio was significantly lower than in Group C. A receiver operating characteristic (ROC) analysis showed that the optimal cut-off point for adiponectin was 6.4 mug/mL (AUC = 0.859). The cut-off points for ALT, the AST/ALT ratio and VAT were 35 IU/L (AUC = 0.821), 0.85 (AUC = 0.794) and 78 cm2 (AUC = 0.713), respectively. Group A had a significantly higher frequency of a family history of T2D than Group B.
+
+ Conclusions: Our study revealed that the adiponectin level, ALT level, AST/ALT ratio, VAT value and a family history of T2D may be critical characteristic markers for T2D among obese Japanese children. Copyright © 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1002%2fedm2.178
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yasuda&issn=2398-9238&title=Endocrinology%2C+and+Diabetes+%26+Metabolism&atitle=Adiponectin%2C+ALT+and+family+history+as+critical+markers+for+the+development+of+type+2+diabetes+in+obese+Japanese+children.&volume=4&issue=1&spage=e00178&epage=&date=2021&doi=10.1002%2Fedm2.178&pmid=33532616&sid=OVID:medline
+
+<889>
+Unique Identifier
+ 33438144
+Title
+ Metabolomics analysis reveals altered metabolites in lean compared with obese adolescents and additional metabolic shifts associated with hyperinsulinaemia and insulin resistance in obese adolescents: a cross-sectional study.
+Source
+ Metabolomics. 17(1):11, 2021 01 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mullner E; Rohnisch HE; von Bromssen C; Moazzami AA
+Author NameID
+ Mullner, Elisabeth; ORCID: http://orcid.org/0000-0003-0714-8588
+ Rohnisch, Hanna E; ORCID: http://orcid.org/0000-0003-0342-9702
+ von Bromssen, Claudia; ORCID: http://orcid.org/0000-0002-1452-8696
+ Moazzami, Ali A; ORCID: http://orcid.org/0000-0003-0994-3972
+Authors Full Name
+ Mullner, Elisabeth; Rohnisch, Hanna E; von Bromssen, Claudia; Moazzami, Ali A.
+Institution
+ Mullner, Elisabeth. Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
+ Rohnisch, Hanna E. Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
+ von Bromssen, Claudia. Department of Energy and Technology, Unit of Applied Statistics and Mathematics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
+ Moazzami, Ali A. Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. ali.moazzami@slu.se.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ Child
+ Cross-Sectional Studies
+ Female
+ Humans
+ Hyperinsulinism/bl [Blood]
+ Hyperinsulinism/ep [Epidemiology]
+ *Hyperinsulinism/me [Metabolism]
+ *Insulin Resistance
+ Longitudinal Studies
+ Male
+ *Metabolome
+ Metabolomics/mt [Methods]
+ *Metabolomics
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Obesity/me [Metabolism]
+ Pediatric Obesity/bl [Blood]
+ Pediatric Obesity/me [Metabolism]
+ Puberty
+ Sweden/ep [Epidemiology]
+Keyword Heading
+ Energy metabolism
+ Hyperinsulinaemia
+ Insulin resistance
+ NMR metabolomics
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Hyperinsulinaemia and insulin resistance (IR) are strongly associated with obesity and are forerunners of type 2 diabetes. Little is known about metabolic alterations separately associated with obesity, hyperinsulinaemia/IR and impaired glucose tolerance (IGT) in adolescents.
+
+ OBJECTIVES: To identify metabolic alterations associated with obesity, hyperinsulinaemia/IR and hyperinsulinaemia/IR combined with IGT in obese adolescents.
+
+ METHODS: 81 adolescents were stratified into four groups based on body mass index (lean vs. obese), insulin responses (normal insulin (NI) vs. high insulin (HI)) and glucose responses (normal glucose tolerance (NGT) vs. IGT) after an oral glucose tolerance test (OGTT). The groups comprised: (1) healthy lean with NI and NGT, (2) obese with NI and NGT, (3) obese with HI and NGT, and (4) obese with HI and IGT. Targeted nuclear magnetic resonance-based metabolomics analysis was performed on fasting and seven post-OGTT plasma samples, followed by univariate and multivariate statistical analyses.
+
+ RESULTS: Two groups of metabolites were identified: (1) Metabolites associated with insulin response level: adolescents with HI (groups 3-4) had higher concentrations of branched-chain amino acids and tyrosine, and lower concentrations of serine, glycine, myo-inositol and dimethylsulfone, than adolescents with NI (groups 1-2). (2) Metabolites associated with obesity status: obese adolescents (groups 2-4) had higher concentrations of acetylcarnitine, alanine, pyruvate and glutamate, and lower concentrations of acetate, than lean adolescents (group 1).
+
+ CONCLUSIONS: Obesity is associated with shifts in fat and energy metabolism. Hyperinsulinaemia/IR in obese adolescents is also associated with increased branched-chain and aromatic amino acids.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs11306-020-01759-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mullner&issn=1573-3882&title=Metabolomics&atitle=Metabolomics+analysis+reveals+altered+metabolites+in+lean+compared+with+obese+adolescents+and+additional+metabolic+shifts+associated+with+hyperinsulinaemia+and+insulin+resistance+in+obese+adolescents%3A+a+cross-sectional+study.&volume=17&issue=1&spage=11&epage=&date=2021&doi=10.1007%2Fs11306-020-01759-y&pmid=33438144&sid=OVID:medline
+
+<890>
+Unique Identifier
+ 33228378
+Title
+ Obesity as a Risk Factor for Radiographic Contrast-Induced Nephropathy.
+Source
+ Angiology. 72(3):274-278, 2021 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kabeer MA; Cross J; Hamilton G; Rashid ST
+Author NameID
+ Rashid, Sheikh Tawqeer; ORCID: https://orcid.org/0000-0002-5377-8671
+Authors Full Name
+ Kabeer, Muhammad Asif; Cross, Jennifer; Hamilton, George; Rashid, Sheikh Tawqeer.
+Institution
+ Kabeer, Muhammad Asif. Department of Vascular Surgery, 9898University Hospitals of North Midlands NHS Trust, UK.
+ Cross, Jennifer. Department of Renal Medicine, Royal Free & University College Medical School and Royal Free Hospital, London, UK.
+ Hamilton, George. Department of Vascular Surgery, Royal Free & University College Medical School and Royal Free Hospital, London, UK.
+ Rashid, Sheikh Tawqeer. Department of Vascular Surgery, Manchester Royal Infirmary, Manchester University NHS Foundation Trust & 5292University of Manchester, UK.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ *Angiography/ae [Adverse Effects]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Contrast Media/ae [Adverse Effects]
+ Creatinine/bl [Blood]
+ Female
+ Humans
+ Kidney/pp [Physiopathology]
+ *Kidney Diseases/ci [Chemically Induced]
+ Kidney Diseases/di [Diagnosis]
+ Kidney Diseases/pp [Physiopathology]
+ Kidney Diseases/th [Therapy]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Peripheral Arterial Disease/co [Complications]
+ *Peripheral Arterial Disease/dg [Diagnostic Imaging]
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ angiography
+ contrast-induced nephropathy
+ obesity
+ peripheral arterial disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Contrast-induced nephropathy (CIN) is common. Risk factors include preexisting renal impairment, diabetes, elderly age, and dehydration. In a single-centre prospective study, we investigated which factors are implicated for CIN in patients with peripheral arterial disease due for angiography. Serum creatinine was measured before, 1, 2, and 7 days post-angiography. We also considered the chronic kidney disease stage of the patients at admission and 48 hours post-contrast. All patients received 500 mL normal saline pre- and post-angiography and a low-osmolality contrast medium. 6 of 94 patients developed CIN: 1 required dialysis and 1 died partly due to renal failure. Only 2 factors were associated with CIN: body mass index (BMI; P = .019) and kidney function (P = .001); 4 of 6 patients with CIN were obese (BMI >=30) and only 2 were nonobese (P = .0092). Diabetes, contrast volume, and age were not significant risk factors. Our results confirm renal impairment raises the risk of CIN. To our knowledge, we report for the first time that obesity may be a risk factor for CIN. Pending confirmatory studies and given the rising prevalence of obesity, this finding could help identify at-risk patients and hence reduce the burden of CIN.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Contrast Media). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1177%2f0003319720969536
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kabeer&issn=0003-3197&title=Angiology&atitle=Obesity+as+a+Risk+Factor+for+Radiographic+Contrast-Induced+Nephropathy.&volume=72&issue=3&spage=274&epage=278&date=2021&doi=10.1177%2F0003319720969536&pmid=33228378&sid=OVID:medline
+
+<891>
+Unique Identifier
+ 33008875
+Title
+ Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis.
+Source
+ Cancer Epidemiology, Biomarkers & Prevention. 30(1):104-113, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dashti SG; English DR; Simpson JA; Karahalios A; Moreno-Betancur M; Biessy C; Rinaldi S; Ferrari P; Tjonneland A; Halkjaer J; Dahm CC; Vistisen HT; Menegaux F; Perduca V; Severi G; Aleksandrova K; Schulze MB; Masala G; Sieri S; Tumino R; Macciotta A; Panico S; Hiensch AE; May AM; Quiros JR; Agudo A; Sanchez MJ; Amiano P; Colorado-Yohar S; Ardanaz E; Allen NE; Weiderpass E; Fortner RT; Christakoudi S; Tsilidis KK; Riboli E; Kaaks R; Gunter MJ; Viallon V; Dossus L
+Author NameID
+ English, Dallas R; ORCID: https://orcid.org/0000-0001-7828-8188
+ Karahalios, Amalia; ORCID: https://orcid.org/0000-0002-7497-1681
+ Tjonneland, Anne; ORCID: https://orcid.org/0000-0003-4385-2097
+ Dahm, Christina C; ORCID: https://orcid.org/0000-0003-0481-2893
+ Menegaux, Florence; ORCID: https://orcid.org/0000-0003-3363-6411
+ Severi, Gianluca; ORCID: https://orcid.org/0000-0001-7157-419X
+ Schulze, Matthias B; ORCID: https://orcid.org/0000-0002-0830-5277
+ Masala, Giovanna; ORCID: https://orcid.org/0000-0002-5758-9069
+ Sanchez, Maria-Jose; ORCID: https://orcid.org/0000-0003-4817-0757
+ Ardanaz, Eva; ORCID: https://orcid.org/0000-0001-8434-2013
+ Allen, Naomi E; ORCID: https://orcid.org/0000-0003-1938-5038
+ Weiderpass, Elisabete; ORCID: https://orcid.org/0000-0003-2237-0128
+ Fortner, Renee Turzanski; ORCID: https://orcid.org/0000-0002-1426-8505
+ Viallon, Vivian; ORCID: https://orcid.org/0000-0002-9799-4421
+ Dossus, Laure; ORCID: https://orcid.org/0000-0003-2716-5748
+Authors Full Name
+ Dashti, S Ghazaleh; English, Dallas R; Simpson, Julie A; Karahalios, Amalia; Moreno-Betancur, Margarita; Biessy, Carine; Rinaldi, Sabina; Ferrari, Pietro; Tjonneland, Anne; Halkjaer, Jytte; Dahm, Christina C; Vistisen, Helene Tilma; Menegaux, Florence; Perduca, Vittorio; Severi, Gianluca; Aleksandrova, Krasimira; Schulze, Matthias B; Masala, Giovanna; Sieri, Sabina; Tumino, Rosario; Macciotta, Alessandra; Panico, Salvatore; Hiensch, Anouk E; May, Anne M; Quiros, J Ramon; Agudo, Antonio; Sanchez, Maria-Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Ardanaz, Eva; Allen, Naomi E; Weiderpass, Elisabete; Fortner, Renee Turzanski; Christakoudi, Sofia; Tsilidis, Konstantinos K; Riboli, Elio; Kaaks, Rudolf; Gunter, Marc J; Viallon, Vivian; Dossus, Laure.
+Institution
+ Dashti, S Ghazaleh. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. ghazaleh.dashti@mcri.edu.au.
+ Dashti, S Ghazaleh. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
+ Dashti, S Ghazaleh. Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia.
+ English, Dallas R. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
+ English, Dallas R. Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
+ Simpson, Julie A. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
+ Karahalios, Amalia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
+ Karahalios, Amalia. School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
+ Moreno-Betancur, Margarita. Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia.
+ Moreno-Betancur, Margarita. Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
+ Biessy, Carine. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
+ Rinaldi, Sabina. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
+ Ferrari, Pietro. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
+ Tjonneland, Anne. Danish Cancer Society Research Center, Copenhagen, Denmark.
+ Halkjaer, Jytte. Danish Cancer Society Research Center, Copenhagen, Denmark.
+ Dahm, Christina C. Department of Public Health, Aarhus University, Aarhus, Denmark.
+ Vistisen, Helene Tilma. Department of Public Health, Aarhus University, Aarhus, Denmark.
+ Menegaux, Florence. Universite Paris-Saclay, UVSQ, CESP U1018 INSERM, Villejuif, France.
+ Perduca, Vittorio. Laboratoire de Mathematiques Appliquees a Paris 5-MAP5 (UMR CNRS 8145), Universite Paris Descartes, Universite de Paris, Paris, France.
+ Severi, Gianluca. Universite Paris-Saclay, UVSQ, CESP U1018 INSERM, Villejuif, France.
+ Severi, Gianluca. Gustave Roussy, Villejuif, France.
+ Severi, Gianluca. Department of Statistics, Computer Science, Applications "G. Parenti," University of Florence, Florence, Italy.
+ Aleksandrova, Krasimira. Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition, Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
+ Aleksandrova, Krasimira. Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
+ Schulze, Matthias B. Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
+ Schulze, Matthias B. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
+ Masala, Giovanna. Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.
+ Sieri, Sabina. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
+ Tumino, Rosario. Cancer Registry and Histopathology Department, Provincial Health Authority (ASP) Ragusa, Ragusa, Italy.
+ Macciotta, Alessandra. Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
+ Panico, Salvatore. Dipoartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy.
+ Hiensch, Anouk E. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
+ May, Anne M. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
+ Quiros, J Ramon. Public Health Directorate, Asturias, Spain.
+ Agudo, Antonio. Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Sanchez, Maria-Jose. Escuela Andaluza de Salud Publica (EASP), Granada, Spain.
+ Sanchez, Maria-Jose. Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain.
+ Sanchez, Maria-Jose. Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
+ Sanchez, Maria-Jose. Universidad de Granada, Granada, Spain.
+ Amiano, Pilar. Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
+ Amiano, Pilar. Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebastian, Spain.
+ Colorado-Yohar, Sandra. Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
+ Colorado-Yohar, Sandra. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
+ Colorado-Yohar, Sandra. Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellin, Colombia.
+ Ardanaz, Eva. Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
+ Ardanaz, Eva. Navarra Public Health Institute, Pamplona, Spain.
+ Ardanaz, Eva. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
+ Allen, Naomi E. Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
+ Weiderpass, Elisabete. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
+ Fortner, Renee Turzanski. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
+ Christakoudi, Sofia. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
+ Christakoudi, Sofia. MRC Centre for Transplantation, King's College London, London, United Kingdom.
+ Tsilidis, Konstantinos K. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
+ Tsilidis, Konstantinos K. Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
+ Riboli, Elio. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
+ Kaaks, Rudolf. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
+ Gunter, Marc J. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
+ Viallon, Vivian. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
+ Dossus, Laure. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ *Adiposity
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ C-Peptide/bl [Blood]
+ Case-Control Studies
+ Causality
+ *Endometrial Neoplasms/bl [Blood]
+ Endometrial Neoplasms/ep [Epidemiology]
+ Estrogens/bl [Blood]
+ Female
+ Humans
+ *Obesity/co [Complications]
+ Odds Ratio
+ Postmenopause
+ Prospective Studies
+ Risk Factors
+Abstract
+ BACKGROUND: Adiposity increases endometrial cancer risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens. We aimed to quantify the mediating effects of adiponectin (anti-inflammatory adipocytokine); IL6, IL1-receptor antagonist, TNF receptor 1 and 2, and C-reactive protein (inflammatory status biomarkers); C-peptide (hyperinsulinemia biomarker); and free estradiol and estrone (estrogen biomarkers) in the adiposity-endometrial cancer link in postmenopausal women.
+
+ METHODS: We used data from a case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). Eligible women did not have cancer, hysterectomy, and diabetes; did not use oral contraceptives or hormone therapy; and were postmenopausal at recruitment. Mediating pathways from adiposity to endometrial cancer were investigated by estimating natural indirect (NIE) and direct (NDE) effects using sequential mediation analysis.
+
+ RESULTS: The study included 163 cases and 306 controls. The adjusted OR for endometrial cancer for body mass index (BMI) >=30 versus >=18.5-<25 kg/m2 was 2.51 (95% confidence interval, 1.26-5.02). The ORsNIE were 1.95 (1.01-3.74) through all biomarkers [72% proportion mediated (PM)] decomposed as: 1.35 (1.06-1.73) through pathways originating with adiponectin (33% PM); 1.13 (0.71-1.80) through inflammation beyond (the potential influence of) adiponectin (13% PM); 1.05 (0.88-1.24) through C-peptide beyond adiponectin and inflammation (5% PM); and 1.22 (0.89-1.67) through estrogens beyond preceding biomarkers (21% PM). The ORNDE not through biomarkers was 1.29 (0.54-3.09). Waist circumference gave similar results.
+
+ CONCLUSIONS: Reduced adiponectin and increased inflammatory biomarkers, C-peptide, and estrogens mediated approximately 70% of increased odds of endometrial cancer in women with obesity versus normal weight.
+
+ IMPACT: If replicated, these results could have implications for identifying targets for intervention to reduce endometrial cancer risk in women with obesity. Copyright ©2020 American Association for Cancer Research.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (C-Peptide). 0 (Estrogens).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1158%2f1055-9965.EPI-20-0965
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dashti&issn=1055-9965&title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&atitle=Adiposity+and+Endometrial+Cancer+Risk+in+Postmenopausal+Women%3A+A+Sequential+Causal+Mediation+Analysis.&volume=30&issue=1&spage=104&epage=113&date=2021&doi=10.1158%2F1055-9965.EPI-20-0965&pmid=33008875&sid=OVID:medline
+
+<892>
+Unique Identifier
+ 33807712
+Title
+ Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats.
+Source
+ Molecules. 26(5), 2021 Mar 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moruzzi M; Kloting N; Bluher M; Martinelli I; Tayebati SK; Gabrielli MG; Roy P; Micioni Di Bonaventura MV; Cifani C; Lupidi G; Amenta F; Tomassoni D
+Author NameID
+ Kloting, Nora; ORCID: https://orcid.org/0000-0002-7625-7254
+ Tayebati, Seyed Khosrow; ORCID: https://orcid.org/0000-0002-7219-6917
+ Micioni Di Bonaventura, Maria Vittoria; ORCID: https://orcid.org/0000-0002-8044-1206
+ Cifani, Carlo; ORCID: https://orcid.org/0000-0001-6180-828X
+ Amenta, Francesco; ORCID: https://orcid.org/0000-0002-0555-1034
+ Tomassoni, Daniele; ORCID: https://orcid.org/0000-0001-9062-3305
+Authors Full Name
+ Moruzzi, Michele; Kloting, Nora; Bluher, Matthias; Martinelli, Ilenia; Tayebati, Seyed Khosrow; Gabrielli, Maria Gabriella; Roy, Proshanta; Micioni Di Bonaventura, Maria Vittoria; Cifani, Carlo; Lupidi, Giulio; Amenta, Francesco; Tomassoni, Daniele.
+Institution
+ Moruzzi, Michele. School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
+ Kloting, Nora. Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum Munchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.
+ Bluher, Matthias. Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum Munchen at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.
+ Martinelli, Ilenia. School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
+ Martinelli, Ilenia. Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Toulouse, 31432 Toulouse, France.
+ Tayebati, Seyed Khosrow. School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
+ Gabrielli, Maria Gabriella. School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.
+ Roy, Proshanta. School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.
+ Micioni Di Bonaventura, Maria Vittoria. School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
+ Cifani, Carlo. School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
+ Lupidi, Giulio. School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
+ Amenta, Francesco. School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
+ Tomassoni, Daniele. School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/me [Metabolism]
+ CD36 Antigens/ge [Genetics]
+ CD36 Antigens/me [Metabolism]
+ Chemokine CCL2/ge [Genetics]
+ Chemokine CCL2/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Dietary Supplements
+ *Fruit and Vegetable Juices
+ Gene Expression Regulation
+ Intra-Abdominal Fat/de [Drug Effects]
+ *Intra-Abdominal Fat/me [Metabolism]
+ Macrophages/de [Drug Effects]
+ Macrophages/pa [Pathology]
+ Male
+ *Obesity/dh [Diet Therapy]
+ Obesity/et [Etiology]
+ Panniculitis/dh [Diet Therapy]
+ Panniculitis/ge [Genetics]
+ Panniculitis/me [Metabolism]
+ *Prunus avium/ch [Chemistry]
+ Rats, Wistar
+ Seeds
+ Rats
+Keyword Heading
+ inflammation
+ obesity
+ tart cherries
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Tart cherries (Prunus cerasus L.) are a rich source of anthocyanins. They are phytochemical flavonoids found in red and blue fruits, and vegetables that can reduce hyperlipidemia. Visceral Adipose Tissue (VAT) has emerged as a major player in driving obesity-related inflammatory response.
+
+ METHODS: This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed ad libitum for 17 weeks with a hypercaloric diet with the supplementation of tart cherries seeds powder (DS) and seeds powder plus tart cherries juice containing 1mg of anthocyanins (DJS). In RPW and PGW, expression of CRP, IL-1 beta, TNF-alpha, CCL2 and CD36, were measured by qRT-PCR, Western blot and immunohistochemistry techniques.
+
+ RESULTS: No differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation.
+
+ CONCLUSION: Study results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CD36 Antigens). 0 (Ccl2 protein, rat). 0 (Chemokine CCL2).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fmolecules26051403
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moruzzi&issn=1420-3049&title=Molecules&atitle=Tart+Cherry+Juice+and+Seeds+Affect+Pro-Inflammatory+Markers+in+Visceral+Adipose+Tissue+of+High-Fat+Diet+Obese+Rats.&volume=26&issue=5&spage=&epage=&date=2021&doi=10.3390%2Fmolecules26051403&pmid=33807712&sid=OVID:medline
+
+<893>
+Unique Identifier
+ 33761942
+Title
+ Countering adipose tissue dysfunction could underlie the superiority of telmisartan in the treatment of obesity-related hypertension.
+Source
+ Cardiovascular Diabetology. 20(1):70, 2021 03 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Naguib YM; Samaka RM; Rizk MS; Ameen O; Motawea SM
+Author NameID
+ Naguib, Yahya M; ORCID: https://orcid.org/0000-0001-5851-7238
+Authors Full Name
+ Naguib, Yahya M; Samaka, Rehab M; Rizk, Mohamed S; Ameen, Omnia; Motawea, Shaimaa M.
+Institution
+ Naguib, Yahya M. Physiology Department, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain. yahyamn@agu.edu.bh.
+ Naguib, Yahya M. Clinical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt. yahyamn@agu.edu.bh.
+ Samaka, Rehab M. Pathology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
+ Rizk, Mohamed S. Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
+ Ameen, Omnia. Clinical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
+ Motawea, Shaimaa M. Clinical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
+MeSH Subject Headings
+ Adiposity/de [Drug Effects]
+ *Angiotensin II Type 1 Receptor Blockers/pd [Pharmacology]
+ Animals
+ *Antihypertensive Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ *Blood Pressure/de [Drug Effects]
+ Disease Models, Animal
+ Hypertension/bl [Blood]
+ *Hypertension/dt [Drug Therapy]
+ Hypertension/et [Etiology]
+ Hypertension/pp [Physiopathology]
+ *Intra-Abdominal Fat/de [Drug Effects]
+ Intra-Abdominal Fat/me [Metabolism]
+ Intra-Abdominal Fat/pp [Physiopathology]
+ Kidney/de [Drug Effects]
+ Kidney/me [Metabolism]
+ Kidney/pp [Physiopathology]
+ Male
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Rats, Wistar
+ *Telmisartan/pd [Pharmacology]
+ Rats
+Keyword Heading
+ Adipose tissue
+ Angiotensin receptor blockers
+ Hypertension
+ Obesity
+ Telmisartan
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The prevalence of hypertension and obesity has increased significantly in recent decades. Hypertension and obesity often coexist, and both are associated with increased cardiovascular mortality. Obese hypertensive patients usually require special anti-hypertensive treatment strategy due to the increased risk of treatment resistance. Molecules that can target both obesity and hypertension underlying pathologies should get more attention. Herein, we evaluated the therapeutic effects of telmisartan, with special interest in visceral adipose tissue dysfunction, in obesity-related hypertension rat model.
+
+ METHODS: Thirty male Wistar rats weighing 150-200 g were equally divided into: 1-Control group (fed normal laboratory diet for 24 weeks), 2-Diet-induced obesity group (DIO, fed high fat diet for 24 weeks), and 3-Diet-induced obesity treated with telmisartan group (DIO + Tel, fed high fat diet and received telmisartan for 24 weeks). At the end of the study, anthropometrical parameters were evaluated. Systolic blood pressure and heart rate were measured. Blood samples were collected for the measurement of serum lipids, adipokines, cardiac, renal, inflammatory, and oxidative stress biomarkers. Kidneys were removed and used for histopathological studies, and visceral adipose tissue was utilized for histopathological, immunohistochemical and RT-PCR studies.
+
+ RESULTS: High fat diet resulted in obesity-related changes in anthropometrical parameters, elevation of blood pressure, increase in heart rate, higher serum levels of cardiac, inflammatory and kidney function biomarkers, with altered serum lipids, adipokines and oxidative stress markers. Morphological changes (H&E and PAS-stained sections) were noticed in kidneys and visceral adipose tissue. Immunohistochemistry and RT-PCR studies confirmed adipose tissue dysfunction and over-expression of inflammatory and oxidative stress proteins. Telmisartan countered obesity-induced alterations in cardiovascular, renal, and adipose tissue functions.
+
+ CONCLUSION: Adipose tissue dysfunction could be the core pathophysiology of obesity-related hypertension. Besides its anti-hypertensive effect, telmisartan had profound actions on visceral adipose tissue structure and function. Attention should be given to polymodal molecules targeting adipose tissue-related disorders.
+Registry Number/Name of Substance
+ 0 (Angiotensin II Type 1 Receptor Blockers). 0 (Antihypertensive Agents). 0 (Biomarkers). U5SYW473RQ (Telmisartan).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1186%2fs12933-021-01259-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Naguib&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Countering+adipose+tissue+dysfunction+could+underlie+the+superiority+of+telmisartan+in+the+treatment+of+obesity-related+hypertension.&volume=20&issue=1&spage=70&epage=&date=2021&doi=10.1186%2Fs12933-021-01259-w&pmid=33761942&sid=OVID:medline
+
+<894>
+Unique Identifier
+ 33735324
+Title
+ Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.
+Source
+ PLoS ONE [Electronic Resource]. 16(3):e0248854, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Larkin BP; Saad S; Glastras SJ; Nguyen LT; Hou M; Chen H; Wang R; Pollock CA
+Authors Full Name
+ Larkin, Benjamin P; Saad, Sonia; Glastras, Sarah J; Nguyen, Long T; Hou, Miao; Chen, Hui; Wang, Rosy; Pollock, Carol A.
+Institution
+ Larkin, Benjamin P. Renal Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia.
+ Saad, Sonia. Renal Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia.
+ Saad, Sonia. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.
+ Glastras, Sarah J. Renal Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia.
+ Glastras, Sarah J. Department of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, Sydney, Australia.
+ Nguyen, Long T. Renal Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia.
+ Hou, Miao. Department of Cardiology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
+ Chen, Hui. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.
+ Wang, Rosy. Renal Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia.
+ Pollock, Carol A. Renal Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia.
+MeSH Subject Headings
+ Albuminuria/co [Complications]
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight
+ Collagen/me [Metabolism]
+ DNA Methylation/de [Drug Effects]
+ DNA Methylation/ge [Genetics]
+ *Diet, High-Fat
+ Female
+ Fibronectins/me [Metabolism]
+ Fibrosis
+ *Hydralazine/pd [Pharmacology]
+ Inflammation/co [Complications]
+ Inflammation/pa [Pathology]
+ Kidney/de [Drug Effects]
+ *Kidney/pa [Pathology]
+ Kidney Glomerulus/de [Drug Effects]
+ Kidney Glomerulus/pa [Pathology]
+ Mice, Inbred C57BL
+ Necrosis
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Oxidative Stress/de [Drug Effects]
+ Pregnancy
+ Mice
+Abstract
+ BACKGROUND: Maternal high fat diet (HFD) promotes chronic kidney disease (CKD) in offspring. This is in accordance with the theory of fetal programming, which suggests adverse conditions occurring in utero predispose offspring to chronic conditions later in life. DNA methylation has been proposed as a key mechanism by which fetal programming occurs and is implicated in CKD progression. DNA demethylating drugs may interrupt the fetal programming of CKD by maternal obesity. Hydralazine, an antihypertensive agent, demethylates DNA at low doses which do not reduce blood pressure. We used a mouse model of maternal obesity to determine whether gestational administration of low-dose hydralazine to mothers can prevent CKD in offspring.
+
+ METHODS: C57BL/6 dams received HFD or chow from 6 weeks prior to mating and were administered subcutaneous hydralazine (5mg/kg) or saline thrice weekly during gestation. Male offspring were weaned to chow and were sacrificed at either postnatal week 9 or week 32. Biometric and metabolic parameters, renal global DNA methylation, renal structural and functional changes and markers of fibrosis, oxidative stress and inflammation were measured in offspring at weeks 9 and 32.
+
+ RESULTS: In week 9 offspring, maternal HFD consumption did not significantly alter anthropometric or metabolic parameters, or renal global DNA methylation. Week 32 offspring had increased renal global DNA methylation, together with albuminuria, glomerulosclerosis, renal fibrosis and oxidative stress. Administration of low-dose hydralazine to obese mothers during gestation reduced renal global DNA methylation and renal fibrotic markers in week 32 offspring.
+
+ CONCLUSION: Gestational hydralazine reduced renal global DNA methylation in offspring of obese mothers and attenuated maternal obesity-induced renal fibrosis. These data support the use of low-dose hydralazine as a demethylating agent to prevent CKD arising in offspring due to maternal HFD consumption.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fibronectins). 26NAK24LS8 (Hydralazine). 9007-34-5 (Collagen).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1371%2fjournal.pone.0248854
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Larkin&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Low-dose+hydralazine+during+gestation+reduces+renal+fibrosis+in+rodent+offspring+exposed+to+maternal+high+fat+diet.&volume=16&issue=3&spage=e0248854&epage=&date=2021&doi=10.1371%2Fjournal.pone.0248854&pmid=33735324&sid=OVID:medline
+
+<895>
+Unique Identifier
+ 33546948
+Title
+ Sex-specific effects of ketogenic diet after pre-exposure to a high-fat, high-sugar diet in rats.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(3):961-971, 2021 03 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sahagun E; Bachman BB; Kinzig KP
+Authors Full Name
+ Sahagun, Elizabeth; Bachman, Brent B; Kinzig, Kimberly P.
+Institution
+ Sahagun, Elizabeth. Purdue University, Department of Psychological Sciences, 703 3rd Street, West Lafayette, IN, 47907, USA. Electronic address: esahagun@purdue.edu.
+ Bachman, Brent B. Purdue University, Department of Psychological Sciences, 703 3rd Street, West Lafayette, IN, 47907, USA.
+ Kinzig, Kimberly P. Purdue University, Department of Psychological Sciences, 703 3rd Street, West Lafayette, IN, 47907, USA.
+MeSH Subject Headings
+ *3-Hydroxybutyric Acid/bl [Blood]
+ Adiposity
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Corticosterone/bl [Blood]
+ *Diet, High-Fat
+ *Diet, Ketogenic
+ *Dietary Sugars
+ Disease Models, Animal
+ Eating
+ Female
+ Glucose Intolerance/bl [Blood]
+ *Glucose Intolerance/dh [Diet Therapy]
+ Glucose Intolerance/et [Etiology]
+ Glucose Intolerance/pp [Physiopathology]
+ Male
+ Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ Rats, Sprague-Dawley
+ Sex Factors
+ Time Factors
+ Weight Gain
+ Rats
+Keyword Heading
+ Corticosterone
+ Glucose tolerance
+ Ketogenic diet
+ Obesity
+ Sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: The objectives were to evaluate the relationship between ketogenic diets, the ketone body beta-hydroxybutyrate (BHB), parameters known to increase risk for cardiovascular and metabolic diseases in both sexes, using a pre-clinical model of obesity.
+
+ METHODS AND RESULTS: Rats had access to a diet high in fat and sugar (HFS) for 12 weeks. After HFS, they switched to chow (HFS-CH) or ketogenic diet (HFS-KD) for 3 weeks to model a dietary intervention. Body weight, adiposity, and food intake were measured. Glucose tolerance and corticosterone response to stress were measured after HFS, then again after the intervention. Both sexes increased body weight, food intake, and adiposity compared to control (CTL) while on HFS. HFS females showed impaired glucose tolerance. HFS males developed a dampened corticosterone to stress, whereas HFS females developed an exacerbated response. The effects of HFS on adiposity and corticosterone were reversed in HFS-CH males. These same improvements were observed in HFS-CH females, although they still had impaired glucose tolerance. HFS-KD males showed some improvements, however, they still had higher body weight and adiposity than CTL. The same pattern was observed in females. These beneficial effects of KD correlated with plasma BHB levels in females but not in males.
+
+ CONCLUSIONS: These data model effects reported in clinical literature and serve as a valuable translational tool to further test causal mechanisms that lead to desirable outcomes of KD. These sex-specific relationships are important, as KD could potentially affect endocrine mechanisms differently in males and females. Copyright © 2020. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Sugars). TZP1275679 (3-Hydroxybutyric Acid). W980KJ009P (Corticosterone).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.numecd.2020.09.034
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sahagun&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Sex-specific+effects+of+ketogenic+diet+after+pre-exposure+to+a+high-fat%2C+high-sugar+diet+in+rats.&volume=31&issue=3&spage=961&epage=971&date=2021&doi=10.1016%2Fj.numecd.2020.09.034&pmid=33546948&sid=OVID:medline
+
+<896>
+Unique Identifier
+ 33378981
+Title
+ The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet.
+Source
+ Biomedicine & Pharmacotherapy. 133:111085, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leisegang K; Almaghrawi W; Henkel R
+Authors Full Name
+ Leisegang, Kristian; Almaghrawi, Walid; Henkel, Ralf.
+Institution
+ Leisegang, Kristian. School of Natural Medicine, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa. Electronic address: kleisegang@uwc.ac.za.
+ Almaghrawi, Walid. Department of Medical Biosciences, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
+ Henkel, Ralf. Department of Medical Biosciences, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa; American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, United States; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
+MeSH Subject Headings
+ Animals
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Disease Models, Animal
+ *Fertility/de [Drug Effects]
+ *Fertility Agents, Male/pd [Pharmacology]
+ Infertility, Male/bl [Blood]
+ Infertility, Male/pa [Pathology]
+ Infertility, Male/pp [Physiopathology]
+ *Infertility, Male/pc [Prevention & Control]
+ Male
+ Membrane Potential, Mitochondrial/de [Drug Effects]
+ *Metformin/pd [Pharmacology]
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pa [Pathology]
+ *Plant Oils/pd [Pharmacology]
+ Rats, Wistar
+ Sperm Count
+ Sperm Motility/de [Drug Effects]
+ *Spermatozoa/de [Drug Effects]
+ Spermatozoa/me [Metabolism]
+ Spermatozoa/pa [Pathology]
+ *Testosterone/bl [Blood]
+ Rats
+Keyword Heading
+ Metformin
+ Nigella sativa
+ Obesity
+ Semen analysis
+ Testosterone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a significant global health and socio-economic challenge, and considered an important risk factor for poor health outcomes including male reproductive dysfunction and infertility. As excess adiposity causes testicular dysfunction and infertility, novel therapeutic strategies require investigation. Nigella sativa (Ns) seed oil and metformin have both demonstrated a potential positive effect on obesity, although both remain poorly investigated in male fertility. Therefore, this study aimed to determine the effect of Ns oil and metformin on total body weight (TBW), mitochondrial membrane potential (MMP), serum testosterone and semen parameters in an obese animal model. Wistar rats (n = 54) were divided into six groups: normal chow (NC), high sugar diet (HSD) only, HSD and saline, HSD and metformin (75 mg/Kg/day), HSD and Ns (200 mg/Kg/day) (NS200), HSD and Ns (400 mg/Kg/day) (NS400). Intervention was force fed for the last 8 weeks of the 14 weeks dietary exposures. Results showed that the HSD increased TBW (P = 0.001) and reduced sperm concentration (P = 0.013) and progressive motility (P = 0.009) compared to the NC group. Metformin, NS200 and NS400 improved TBW (P = 0.035, P = 0.006 and P = 0.005, respectively) and testosterone (P < 0.001) compared to the HSD saline group, where metformin and NS400 improved sperm concentration (P < 0.001 and P = 0.049, respectively) and MMP (P < 0.001). There were no changes in sperm motility and viability for all experimental exposures, although NS400 (P = 0.047) negatively affected sperm viability. Metformin and Ns may be novel treatment options in obesity-induced infertility, although a potential negative impact on viability is cautioned for high dose Ns. These results warrant further investigation of Ns and Metformin for the management of obese infertile males. Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Fertility Agents, Male). 0 (Plant Oils). 3XMK78S47O (Testosterone). 9100L32L2N (Metformin). C2J9B08Q3I (caraway oil).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.biopha.2020.111085
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leisegang&issn=0753-3322&title=Biomedicine+%26+Pharmacotherapy&atitle=The+effect+of+Nigella+sativa+oil+and+metformin+on+male+seminal+parameters+and+testosterone+in+Wistar+rats+exposed+to+an+obesogenic+diet.&volume=133&issue=&spage=111085&epage=&date=2021&doi=10.1016%2Fj.biopha.2020.111085&pmid=33378981&sid=OVID:medline
+
+<897>
+Unique Identifier
+ 33345901
+Title
+ Subchronic toxicity evaluation of glucosamine and glucosamine in combination with chondroitin sulfate in obese Zucker rats.
+Source
+ Toxicology & Applied Pharmacology. 412:115371, 2021 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leakey JEA; Ali AA; Babb AR; Badgley HL; Davis KJ; Juliar BE; Leakey TI; Lewis SM; Patton RE; Seng JE
+Authors Full Name
+ Leakey, Julian E A; Ali, A Afshan; Babb, Amy R; Badgley, Heidi L; Davis, Kelly J; Juliar, Beth E; Leakey, Tatiana I; Lewis, Sherry M; Patton, Ralph E; Seng, John E.
+Institution
+ Leakey, Julian E A. Office of Scientific Coordination, 3900 NCTR Rd., Jefferson, AR 72079, United States of America. Electronic address: julian.leakey@fda.hhs.gov.
+ Ali, A Afshan. Office of Scientific Coordination, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+ Babb, Amy R. Office of Scientific Coordination, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+ Badgley, Heidi L. Toxicologic Pathology Associates, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+ Davis, Kelly J. Toxicologic Pathology Associates, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+ Juliar, Beth E. Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+ Leakey, Tatiana I. Office of Scientific Coordination, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+ Lewis, Sherry M. Office of Scientific Coordination, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+ Patton, Ralph E. Toxicologic Pathology Associates, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+ Seng, John E. Toxicologic Pathology Associates, 3900 NCTR Rd., Jefferson, AR 72079, United States of America.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Chondroitin Sulfates/to [Toxicity]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Disease Models, Animal
+ *Glucosamine/to [Toxicity]
+ Kidney/de [Drug Effects]
+ Kidney/me [Metabolism]
+ Kidney/pa [Pathology]
+ Lung/de [Drug Effects]
+ Lung/me [Metabolism]
+ Lung/pa [Pathology]
+ Male
+ Metaplasia
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Rats, Zucker
+ Risk Assessment
+ Risk Factors
+ Time Factors
+ Toxicity Tests, Subchronic
+ Transforming Growth Factor beta1/ur [Urine]
+ Rats
+Keyword Heading
+ Chondroitin sulfate
+ Diabetes
+ Glucosamine
+ Subchronic study
+ TGFbeta
+ Zucker rat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ D-glucosamine is a widely consumed dietary supplement used to promote joint health and treat osteoarthritis. It also stimulates intracellular hexosamine flux and increases transforming growth factor beta1 (TGFbeta1) mRNA expression and insulin resistance in animal studies. The effects of D-glucosamine exposure were investigated in obese Zucker rats. Male (leprfa/leprfa) Zucker rats were exposed to 30, 120, 300 and 600 mg D-glucosamine HCl per kg/day either alone or with chondroitin sulfate (24, 96, 240 and 480 mg/kg/day respectively) for 90 days. After 4 weeks exposure, these doses produced CmaxD-glucosamine concentrations of up to 24 muM in tail vein serum concurrent with a transient 30% increase in blood glucose concentration in the 600 mg/kg/day dose group. D-Glucosamine did not significantly alter body weight, blood glucose or serum insulin levels at any dose tested after 13 weeks exposure, but did increase urinary TGFbeta1 concentrations. The Zucker rats developed nephropathy and scrotal sores that were related to their hyperglycemia and obesity, and D-glucosamine exposure exacerbated these conditions to a small extent. The incidence of pulmonary osseous metaplasia was increased in rats exposed to D-glucosamine and a single incidence of adrenal osseous metaplasia was noted in one animal exposed to 600/480 mg D-glucosamine HCl/chondroitin sulfate. These lesions may have been treatment related. These studies suggest that the risk of adverse effects of oral D-glucosamine is small compared to that of hyperglycemia in these animals, but the potential for TGFbeta1-mediated pathologies, such as osseous metaplasia and renal nephropathy may be increased. Copyright © 2020. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Tgfb1 protein, rat). 0 (Transforming Growth Factor beta1). 9007-28-7 (Chondroitin Sulfates). N08U5BOQ1K (Glucosamine).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.taap.2020.115371
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leakey&issn=0041-008X&title=Toxicology+%26+Applied+Pharmacology&atitle=Subchronic+toxicity+evaluation+of+glucosamine+and+glucosamine+in+combination+with+chondroitin+sulfate+in+obese+Zucker+rats.&volume=412&issue=&spage=115371&epage=&date=2021&doi=10.1016%2Fj.taap.2020.115371&pmid=33345901&sid=OVID:medline
+
+<898>
+Unique Identifier
+ 33296297
+Title
+ Obesity-induced Vitamin D Deficiency Contributes to Lung Fibrosis and Airway Hyperresponsiveness.
+Source
+ American Journal of Respiratory Cell & Molecular Biology. 64(3):357-367, 2021 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Han H; Chung SI; Park HJ; Oh EY; Kim SR; Park KH; Lee JH; Park JW
+Author NameID
+ Han, Heejae; ORCID: https://orcid.org/0000-0003-2025-7826
+ Chung, Sook In; ORCID: https://orcid.org/0000-0002-7915-9203
+ Park, Hye Jung; ORCID: https://orcid.org/0000-0002-1862-1003
+ Kim, Sung-Ryeol; ORCID: https://orcid.org/0000-0001-7418-0049
+ Park, Kyung Hee; ORCID: https://orcid.org/0000-0003-3605-5364
+ Lee, Jae-Hyun; ORCID: https://orcid.org/0000-0002-0760-0071
+ Park, Jung-Won; ORCID: https://orcid.org/0000-0003-0249-8749
+Authors Full Name
+ Han, Heejae; Chung, Sook In; Park, Hye Jung; Oh, Eun Yi; Kim, Sung-Ryeol; Park, Kyung Hee; Lee, Jae-Hyun; Park, Jung-Won.
+Institution
+ Han, Heejae. Institute for Allergy.
+ Chung, Sook In. Institute for Allergy.
+ Park, Hye Jung. Department of Internal Medicine and Gangnam Severance Hospital, and.
+ Oh, Eun Yi. Institute for Allergy.
+ Kim, Sung-Ryeol. Institute for Allergy.
+ Kim, Sung-Ryeol. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
+ Park, Kyung Hee. Institute for Allergy.
+ Park, Kyung Hee. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
+ Lee, Jae-Hyun. Institute for Allergy.
+ Lee, Jae-Hyun. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
+ Park, Jung-Won. Institute for Allergy.
+ Park, Jung-Won. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ Cells, Cultured
+ Cytokines/me [Metabolism]
+ Diet, High-Fat
+ Dietary Supplements
+ Epithelial-Mesenchymal Transition/de [Drug Effects]
+ Glucose Tolerance Test
+ Inflammation/pa [Pathology]
+ Insulin/me [Metabolism]
+ Leptin/bl [Blood]
+ Lung/me [Metabolism]
+ Lung/pa [Pathology]
+ Male
+ Methacholine Chloride
+ Mice, Inbred C57BL
+ Mice, Transgenic
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Pulmonary Fibrosis/bl [Blood]
+ *Pulmonary Fibrosis/et [Etiology]
+ Receptors, Calcitriol/me [Metabolism]
+ Renin/bl [Blood]
+ Renin-Angiotensin System/de [Drug Effects]
+ Respiratory Hypersensitivity/bl [Blood]
+ *Respiratory Hypersensitivity/et [Etiology]
+ Transforming Growth Factor beta1/me [Metabolism]
+ Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ Vitamin D/pd [Pharmacology]
+ Vitamin D Deficiency/bl [Blood]
+ *Vitamin D Deficiency/et [Etiology]
+ Mice
+Keyword Heading
+ asthma
+ lung fibrosis
+ obesity
+ transforming growth factor-beta1
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Vitamin D (VitD) has pleiotropic effects. VitD deficiency is closely involved with obesity and may contribute to the development of lung fibrosis and aggravation of airway hyperresponsiveness (AHR). We evaluated the causal relationship between VitD deficiency and the lung pathologies associated with obesity. In vivo effects of VitD supplementation were analyzed using high-fat diet (HFD)-induced obese mice and TGF-beta1 (transforming growth factor-beta1) triple transgenic mice. Effects of VitD supplementation were also evaluated in both BEAS-2B and primary lung cells from the transgenic mice. Obese mice had decreased 25-OH VitD and VitD receptor expressions with increases of insulin resistance, renin and angiotensin-2 system (RAS) activity, and leptin. In addition, lung pathologies such as a modest increase in macrophages, enhanced TGF-beta1, IL-1beta, and IL-6 expression, lung fibrosis, and AHR were found. VitD supplementation to HFD-induced obese mice recovered these findings. TGF-beta1-overexpressing transgenic mice enhanced macrophages in BAL fluid, lung expression of RAS, epithelial-mesenchymal transition markers, AHR, and lung fibrosis. VitD supplementation also attenuated these findings in addition to the attenuation of the expressions of TGF-beta1, and phosphorylated Smad-2/3 in lung. Supplementing in vitro-stimulated BEAS-2B and primary lung cells with VitD inhibited TGF-beta1 expression, supporting the suppressive effect of VitD for TGF-beta1 expression. These results suggest that obesity leads to VitD deficiency and worsens insulin resistance while enhancing the expression of leptin, RAS, TGF-beta1, and proinflammatory cytokines. These changes may contribute to the development of lung fibrosis and AHR. VitD supplementation rescues these changes and may have therapeutic potential for asthma with obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Insulin). 0 (Leptin). 0 (Receptors, Calcitriol). 0 (Transforming Growth Factor beta1). 0W5ETF9M2K (Methacholine Chloride). 1406-16-2 (Vitamin D). A288AR3C9H (25-hydroxyvitamin D). EC 3-4-23-15 (Renin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1165%2frcmb.2020-0086OC
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Han&issn=1044-1549&title=American+Journal+of+Respiratory+Cell+%26+Molecular+Biology&atitle=Obesity-induced+Vitamin+D+Deficiency+Contributes+to+Lung+Fibrosis+and+Airway+Hyperresponsiveness.&volume=64&issue=3&spage=357&epage=367&date=2021&doi=10.1165%2Frcmb.2020-0086OC&pmid=33296297&sid=OVID:medline
+
+<899>
+Unique Identifier
+ 33246225
+Title
+ Akkermansia muciniphila: A potential novel mechanism of nuciferine to improve hyperlipidemia.
+Source
+ Biomedicine & Pharmacotherapy. 133:111014, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yu Y; Lu J; Sun L; Lyu X; Chang XY; Mi X; Hu MG; Wu C; Chen X
+Authors Full Name
+ Yu, Yue; Lu, Juan; Sun, Le; Lyu, Xinkai; Chang, Xin-Yue; Mi, Xiao; Hu, Mei-Geng; Wu, Chongming; Chen, Xi.
+Institution
+ Yu, Yue. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
+ Lu, Juan. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
+ Sun, Le. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
+ Lyu, Xinkai. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
+ Chang, Xin-Yue. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
+ Mi, Xiao. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
+ Hu, Mei-Geng. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
+ Wu, Chongming. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China. Electronic address: cmwu@implad.ac.cn.
+ Chen, Xi. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China. Electronic address: chenx_implad@163.com.
+MeSH Subject Headings
+ Akkermansia/de [Drug Effects]
+ Akkermansia/ge [Genetics]
+ Akkermansia/gd [Growth & Development]
+ Animals
+ Anti-Bacterial Agents/pd [Pharmacology]
+ *Aporphines/pd [Pharmacology]
+ Bacteroides/de [Drug Effects]
+ Bacteroides/ge [Genetics]
+ Bacteroides/gd [Growth & Development]
+ Biomarkers/bl [Blood]
+ Diet, High-Fat
+ Disease Models, Animal
+ *Gastrointestinal Microbiome/de [Drug Effects]
+ Hyperlipidemias/bl [Blood]
+ *Hyperlipidemias/dt [Drug Therapy]
+ Hyperlipidemias/mi [Microbiology]
+ *Hypolipidemic Agents/pd [Pharmacology]
+ *Intestines/mi [Microbiology]
+ *Lipids/bl [Blood]
+ Male
+ Metagenome
+ Metagenomics
+ Mice, Inbred C57BL
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/mi [Microbiology]
+ Non-alcoholic Fatty Liver Disease/pc [Prevention & Control]
+ Obesity/bl [Blood]
+ Obesity/mi [Microbiology]
+ Obesity/pc [Prevention & Control]
+ RNA-Seq
+ Mice
+Keyword Heading
+ Akkermanisa municiphila
+ Hyperlipidemia
+ Intestinal microbiota
+ Lotus
+ Nuciferine
+ Phytotherapy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Intestinal microbiota is a novel drug target of metabolic diseases, especially for those with poor oral bioavailability. Nuciferine, with poor bioavailability, has an anti-hyperlipidemic effect at low dosages.
+
+ PURPOSE: In the present study, we aimed to explore the role of intestinal microbiota in the anti-hyperlipidemic function of nuciferine and identify the key bacterial targets that might confer the therapeutic actions.
+
+ METHODS: The contribution of gut microbes in the anti-hyperlipidemic effect of nuciferine was evaluated by conventional and antibiotic-established pseudo-sterile mice. Whole-metagenome shotgun sequencing was used to characterize the changes in microbial communities by various agents.
+
+ RESULTS: Nuciferine exhibited potent anti-hyperlipidemic and liver steatosis-alleviating effects at the doses of 7.5-30 mg/kg. The beneficial effects of nuciferine were substantially abolished when combined with antibiotics. Metagenomic analysis showed that nuciferine significantly shifted the microbial structure, and the enrichment of Akkermansia muciniphila was closely related to the therapeutic effect of nuciferine.
+
+ CONCLUSIONS: Our results revealed that gut microbiota played an essential role in the anti-hyperlipidemic effect of nuciferine, and enrichment of Akkermansia muciniphila represented a key mechanism through which nuciferine exerted its therapeutic effects. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Bacterial Agents). 0 (Aporphines). 0 (Biomarkers). 0 (Hypolipidemic Agents). 0 (Lipids). W26UEB90B7 (nuciferine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.biopha.2020.111014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yu&issn=0753-3322&title=Biomedicine+%26+Pharmacotherapy&atitle=Akkermansia+muciniphila%3A+A+potential+novel+mechanism+of+nuciferine+to+improve+hyperlipidemia.&volume=133&issue=&spage=111014&epage=&date=2021&doi=10.1016%2Fj.biopha.2020.111014&pmid=33246225&sid=OVID:medline
+
+<900>
+Unique Identifier
+ 33865923
+Title
+ Dyslipidemia influences the effect of physical exercise on inflammatory markers on obese women in post-menopause: A randomized clinical trial.
+Source
+ Experimental Gerontology. 150:111355, 2021 07 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Biteli P; Barbalho SM; Detregiachi CRP; Dos Santos Haber JF; Chagas EFB
+Authors Full Name
+ Biteli, Piero; Barbalho, Sandra Maria; Detregiachi, Claudia Rucco Penteado; Dos Santos Haber, Jesselina Francisco; Chagas, Eduardo Federighi Baisi.
+Institution
+ Biteli, Piero. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, UNIMAR, Marilia, SP, Brazil.
+ Barbalho, Sandra Maria. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, UNIMAR, Marilia, SP, Brazil; School of Medicine, University of Marilia (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marilia, Sao Paulo, Brazil; School of Food and Technology of Marilia (FATEC), Marilia, SP, Brazil. Electronic address: smbarbalho@gmail.com.
+ Detregiachi, Claudia Rucco Penteado. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, UNIMAR, Marilia, SP, Brazil.
+ Dos Santos Haber, Jesselina Francisco. School of Medicine, University of Marilia (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marilia, Sao Paulo, Brazil.
+ Chagas, Eduardo Federighi Baisi. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, UNIMAR, Marilia, SP, Brazil.
+MeSH Subject Headings
+ Biomarkers
+ Dyslipidemias/th [Therapy]
+ *Dyslipidemias
+ Exercise
+ Female
+ Humans
+ Obesity/th [Therapy]
+ *Postmenopause
+ Tumor Necrosis Factor-alpha
+Keyword Heading
+ Dyslipidemia
+ Exercise
+ Interleukin-6
+ Obese women
+ Post-menopause
+ Tumor Necrosis Factor-alpha
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The hormonal modifications observed in post-menopausal are related to increased adiposity and alteration in the lipid profile besides physical and psychological changes. Physical exercises may attenuate these conditions and have been associated with low-grade inflammatory status, reducing the risk of cardiovascular diseases. This study aimed to evaluate the influence of dyslipidemia on the effect of physical exercise on inflammatory markers IL6, IL10, and TNF-alpha in obese post-menopausal women. A randomized clinical trial was carried out in seventy women divided into four groups: exercise without dyslipidemia (EG/n = 11); exercise with dyslipidemia (EGD = 24); control with dyslipidemia (CGD/n = 22); and control without dyslipidemia (CG/n = 13). The serum values of IL-6, IL-10, and TNF-alpha were measured before and after the intervention period, and the exercise program lasted 20 weeks, in three weekly sessions of 75 min each, with aerobic and strength exercises. The comparison of means was performed using the ANOVA test, repeated measures to analyze the interaction between the group and intervention time. There were a significant reduction in IL-6 values and an increase in IL-10/IL-6 and IL-10/TNF-alpha ratios only in the EG group. For serum TNF-alpha values, the EG and EGD groups showed significant reductions. The groups that practiced exercises did not present significant variation in the levels of IL-10. However, the CGD and GC groups showed a significant reduction in IL-10 after the intervention period. Copyright © 2021. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.exger.2021.111355
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Biteli&issn=0531-5565&title=Experimental+Gerontology&atitle=Dyslipidemia+influences+the+effect+of+physical+exercise+on+inflammatory+markers+on+obese+women+in+post-menopause%3A+A+randomized+clinical+trial.&volume=150&issue=&spage=111355&epage=&date=2021&doi=10.1016%2Fj.exger.2021.111355&pmid=33865923&sid=OVID:medline
+
+<901>
+Unique Identifier
+ 33859244
+Title
+ Obesity-related proteins score as a potential marker of breast cancer risk.
+Source
+ Scientific Reports. 11(1):8230, 2021 04 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Diao S; Wu X; Zhang X; Hao Y; Xu B; Li X; Tian L; Miao Y; Zhao X; Ye F; Li J
+Authors Full Name
+ Diao, Sha; Wu, Xueyao; Zhang, Xiaofan; Hao, Yu; Xu, Bin; Li, Xu; Tian, Lulu; Miao, Yunqi; Zhao, Xunying; Ye, Feng; Li, Jiayuan.
+Institution
+ Diao, Sha. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Diao, Sha. Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Wu, Xueyao. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Zhang, Xiaofan. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Hao, Yu. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Xu, Bin. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Li, Xu. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Li, Xu. Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Tian, Lulu. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Miao, Yunqi. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Zhao, Xunying. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
+ Ye, Feng. Institute of Clinical Pathology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. University.fengye@scu.edu.cn.
+ Li, Jiayuan. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. lijiayuan73@163.com.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/an [Analysis]
+ *Biomarkers/bl [Blood]
+ Breast Neoplasms/bl [Blood]
+ *Breast Neoplasms/di [Diagnosis]
+ Breast Neoplasms/ep [Epidemiology]
+ Breast Neoplasms/et [Etiology]
+ Case-Control Studies
+ China/ep [Epidemiology]
+ Female
+ Humans
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Postmenopause/bl [Blood]
+ Premenopause/bl [Blood]
+ Research Design
+ Risk Factors
+Abstract
+ There is strong evidence to suggest that obesity-related proteins play a key role in pathways that are related to breast cancer. In this study, we aimed to establish a robust obesity-related protein score (ORPS) that could be used to assess breast cancer risk. Based on evidence from high-quality systematic reviews and population studies, we selected nine such proteins that are stable in vitro, and measured their circulating concentrations by ELISA in a case-control study conducted in Chengdu, Sichuan, China, with 279 breast cancer cases and 260 healthy controls. Two obesity-related protein scores (ORPS) were calculated using a three-step method, with linear-weighted summation, and the one with a larger area under the curve was chosen for further evaluation. As a result, ORPS (PS5pre or PS4post) was positively correlated with breast cancer risk (premenopausal: OR<=63 VS >63 3.696, 95% CI 2.025-6.747; postmenopausal: OR<=38 VS >38 7.100, 95% CI 3.134-16.084), and represented a better risk predictor among obese women compared to non-obese in pre- and postmenopausal women. Among different molecular subtypes, ORPS was positively correlated with Luminal breast cancer, with additionally positive association with triple-negative breast cancer in premenopausal women. The ORPS might be a potential marker of breast cancer risk among Chinese women.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-87583-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Diao&issn=2045-2322&title=Scientific+Reports&atitle=Obesity-related+proteins+score+as+a+potential+marker+of+breast+cancer+risk.&volume=11&issue=1&spage=8230&epage=&date=2021&doi=10.1038%2Fs41598-021-87583-3&pmid=33859244&sid=OVID:medline
+
+<902>
+Unique Identifier
+ 33853850
+Title
+ Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort.
+Source
+ Cancer Epidemiology, Biomarkers & Prevention. 30(8):1480-1488, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cirillo PM; La Merrill MA; Krigbaum NY; Cohn BA
+Author NameID
+ La Merrill, Michele A; ORCID: https://orcid.org/0000-0002-5720-5862
+ Krigbaum, Nickilou Y; ORCID: https://orcid.org/0000-0001-5034-7991
+ Cohn, Barbara A; ORCID: https://orcid.org/0000-0002-9912-8447
+Authors Full Name
+ Cirillo, Piera M; La Merrill, Michele A; Krigbaum, Nickilou Y; Cohn, Barbara A.
+Institution
+ Cirillo, Piera M. Child Health and Development Studies of the Public Health Institute, Berkeley, California.
+ La Merrill, Michele A. Department of Environmental Toxicology, University of California, Davis, Davis California.
+ Krigbaum, Nickilou Y. Child Health and Development Studies of the Public Health Institute, Berkeley, California.
+ Cohn, Barbara A. Child Health and Development Studies of the Public Health Institute, Berkeley, California. bcohn@chdstudies.org.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *DDT/bl [Blood]
+ DDT/to [Toxicity]
+ *Environmental Exposure/ae [Adverse Effects]
+ *Environmental Pollutants/bl [Blood]
+ Environmental Pollutants/to [Toxicity]
+ Female
+ Humans
+ Longitudinal Studies
+ *Maternal Exposure/ae [Adverse Effects]
+ *Menarche
+ Middle Aged
+ *Obesity/ci [Chemically Induced]
+ Pregnancy
+ *Prenatal Exposure Delayed Effects/ci [Chemically Induced]
+ Risk Factors
+Abstract
+ BACKGROUND: Serum DDTs during or just after pregnancy were associated with breast cancer in mothers (F0), and with breast cancer, mammographic density, and obesity in adult daughters (F1) in the Child Health and Development Studies multi-generational cohort in prior publications. Here, we investigate F0 perinatal serum DDT associations with granddaughters'(F2) measured obesity at a median age of 26 and self-reported age at menarche.
+
+ METHODS: F2 weight, height and waist circumference were measured by trained examiners. o,p'-DDT, p,p'-DDT and p,p'-DDE were measured in archived F0 perinatal serum. F0 DDT associations with F2 outcomes, accounting for F1 characteristics, were estimated in log-linear models adjusted for F0 and F1 body mass index (BMI), race, and menarche timing (N = 258 triads for obesity; N = 235 triads for early menarche). Interactions between F0 BMI and DDTs were estimated.
+
+ RESULTS: F0 o,p'-DDT was associated with F2 obesity [Odds ratio (OR), 2.6; 95% confidence interval (CI), 1.3-6.7; tertile 3 vs. 1), among normal weight F0 (70%), but not among overweight and obese F0 (P interaction = 0.03), independent of other DDTs. F0 o,p'-DDT was also associated with F2 early menarche (OR, 2.1; 95% CI, 1.1-3.9, tertile 3 vs. 1) and this association was not modified by F0 BMI.
+
+ CONCLUSIONS: Ancestral exposure to environmental chemicals, banned decades ago, may influence the development of earlier menarche and obesity, which are established risk factors for breast cancer and cardiometabolic diseases.
+
+ IMPACT: Discovery of actionable biomarkers of response to ancestral environmental exposures in young women may provide opportunities for breast cancer prevention. See related commentary by Fenton and Boyles, p. 1459. Copyright ©2021 American Association for Cancer Research.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Environmental Pollutants). CIW5S16655 (DDT).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1158%2f1055-9965.EPI-20-1456
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cirillo&issn=1055-9965&title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&atitle=Grandmaternal+Perinatal+Serum+DDT+in+Relation+to+Granddaughter+Early+Menarche+and+Adult+Obesity%3A+Three+Generations+in+the+Child+Health+and+Development+Studies+Cohort.&volume=30&issue=8&spage=1480&epage=1488&date=2021&doi=10.1158%2F1055-9965.EPI-20-1456&pmid=33853850&sid=OVID:medline
+
+<903>
+Unique Identifier
+ 33853349
+Title
+ Vascular Regenerative Capacity and the Obesity Paradox in Coronary Artery Disease.
+Source
+ Arteriosclerosis, Thrombosis & Vascular Biology. 41(6):2097-2108, 2021 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mehta A; Meng Q; Li X; Desai SR; D'Souza MS; Ho AH; Islam SJ; Dhindsa DS; Almuwaqqat Z; Nayak A; Alkhoder AA; Hooda A; Varughese A; Ahmad SF; Mokhtari A; Hesaroieh I; Sperling LS; Ko YA; Waller EK; Quyyumi AA
+Authors Full Name
+ Mehta, Anurag; Meng, Qi; Li, Xiaona; Desai, Shivang R; D'Souza, Melroy S; Ho, Annie H; Islam, Shabatun J; Dhindsa, Devinder S; Almuwaqqat, Zakaria; Nayak, Aditi; Alkhoder, Ayman A; Hooda, Ananya; Varughese, Anil; Ahmad, Syed F; Mokhtari, Ali; Hesaroieh, Iraj; Sperling, Laurence S; Ko, Yi-An; Waller, Edmund K; Quyyumi, Arshed A.
+Institution
+ Mehta, Anurag. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Meng, Qi. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA (Q.M., X.L., Y.-A.K.).
+ Li, Xiaona. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA (Q.M., X.L., Y.-A.K.).
+ Desai, Shivang R. Department of Medicine (S.R.D., M.S.D., A.H.H.), Emory University School of Medicine, Atlanta, GA.
+ D'Souza, Melroy S. Department of Medicine (S.R.D., M.S.D., A.H.H.), Emory University School of Medicine, Atlanta, GA.
+ Ho, Annie H. Department of Medicine (S.R.D., M.S.D., A.H.H.), Emory University School of Medicine, Atlanta, GA.
+ Islam, Shabatun J. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Dhindsa, Devinder S. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Almuwaqqat, Zakaria. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Nayak, Aditi. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Alkhoder, Ayman A. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Hooda, Ananya. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Varughese, Anil. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Ahmad, Syed F. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Mokhtari, Ali. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Hesaroieh, Iraj. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Sperling, Laurence S. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Ko, Yi-An. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+ Ko, Yi-An. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA (Q.M., X.L., Y.-A.K.).
+ Waller, Edmund K. Department of Hematology and Oncology, Winship Cancer Institute (E.K.W.), Emory University School of Medicine, Atlanta, GA.
+ Quyyumi, Arshed A. Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute (A. Mehta, S.J.I., D.S.D., Z.A., A.N., A.A.A., A.H., A.V., S.F.A., A. Mokhtari, I.H., L.S.S., Y.-A.K., A.A.Q.), Emory University School of Medicine, Atlanta, GA.
+MeSH Subject Headings
+ AC133 Antigen/bl [Blood]
+ Adult
+ Antigens, CD34/bl [Blood]
+ Biomarkers/bl [Blood]
+ Cell Count
+ Coronary Artery Disease/bl [Blood]
+ Coronary Artery Disease/mo [Mortality]
+ *Coronary Artery Disease/pa [Pathology]
+ Coronary Artery Disease/pp [Physiopathology]
+ Female
+ Humans
+ Incidence
+ Leukocyte Common Antigens/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/mo [Mortality]
+ *Obesity/pa [Pathology]
+ Obesity/pp [Physiopathology]
+ Phenotype
+ Prognosis
+ Receptors, CXCR4/bl [Blood]
+ *Regeneration
+ Registries
+ Risk Assessment
+ Risk Factors
+ Stem Cells/me [Metabolism]
+ *Stem Cells/pa [Pathology]
+ Time Factors
+ *Vascular Remodeling
+Keyword Heading
+ body mass index
+ cardiovascular diseases
+ inflammation
+ stem cells
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ [Figure: see text].
+Registry Number/Name of Substance
+ 0 (AC133 Antigen). 0 (Antigens, CD34). 0 (Biomarkers). 0 (CXCR4 protein, human). 0 (PROM1 protein, human). 0 (Receptors, CXCR4). EC 3-1-3-48 (Leukocyte Common Antigens). EC 3-1-3-48 (PTPRC protein, human).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1161%2fATVBAHA.120.315703
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mehta&issn=1079-5642&title=Arteriosclerosis%2C+Thrombosis+%26+Vascular+Biology&atitle=Vascular+Regenerative+Capacity+and+the+Obesity+Paradox+in+Coronary+Artery+Disease.&volume=41&issue=6&spage=2097&epage=2108&date=2021&doi=10.1161%2FATVBAHA.120.315703&pmid=33853349&sid=OVID:medline
+
+<904>
+Unique Identifier
+ 33851684
+Title
+ Resistance training exercises for obese and non-obese individuals living in high-altitude regions utilizing biochemical markers-A controlled trial.
+Source
+ Nigerian Journal of Clinical Practice. 24(4):600-607, 2021 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ahmad I; Zaman GS; Silvian SP; Alshaharani MS; Ahmad I; Mansuri N; Fayazuddin S
+Authors Full Name
+ Ahmad, I; Zaman, G S; Silvian, S P; Alshaharani, M S; Ahmad, I; Mansuri, N; Fayazuddin, S.
+Institution
+ Ahmad, I. Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
+ Zaman, G S. Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
+ Silvian, S P. Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
+ Alshaharani, M S. Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
+ Ahmad, I. Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
+ Mansuri, N. Department of Microbiology, Hopkins Medical Laboratory and Research, New Delhi, India.
+ Fayazuddin, S. Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
+MeSH Subject Headings
+ Adult
+ *Altitude
+ Biomarkers
+ Body Mass Index
+ Humans
+ Obesity/ep [Epidemiology]
+ *Resistance Training
+ Saudi Arabia
+Keyword Heading
+ Biomarkers
+ High-altitude
+ obesity
+ resistance training
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: High-altitude disease prevalence varies according to types of exposure and the effects of hypoxic and hypobaric environments, with the result that people at high altitudes present many different physiological responses.
+
+ AIMS: The research aims to analyze the effects of resistance training (RT) exercises at high altitudes on obese subjects and to explain the determinants that make obese people more susceptible to various chronic illnesses such as diabetes mellitus, hypertension, asthma, etc.
+
+ METHODS: This study recruited 225 subjects living in the high-altitude region of Aseer, Saudi Arabia, and divided them into three groups. The first two groups consisted of obese people, out of which one group received RT and one did not. The third group consisted of average-weight individuals, according to their BMI, who received RT. Biochemical parameters were checked for all three groups before commencing with the RT and at the 4th and 8th week to measure the effects of the exercise.
+
+ RESULTS: Mean and standard deviations of the demographic variables: age was 34.2 +/- 8.9 years, weight was 69.3 +/- 8.5 kg, and height was 1.6 +/- 0.06 meters. RT had a significant effect on the total levels of cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, adiponectin, interleukin-6, and testosterone. Post-hoc comparisons using the Fisher's Least Significant Difference test indicated that the mean scores between the groups differed significantly.
+
+ CONCLUSION: Our findings show that RT would be a useful and practical substitute to improve the health status of obese patients. It helps to decrease body fat and to improve lipid profiles and hormonal control.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.4103%2fnjcp.njcp_277_19
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ahmad&issn=1119-3077&title=Nigerian+Journal+of+Clinical+Practice&atitle=Resistance+training+exercises+for+obese+and+non-obese+individuals+living+in+high-altitude+regions+utilizing+biochemical+markers-A+controlled+trial.&volume=24&issue=4&spage=600&epage=607&date=2021&doi=10.4103%2Fnjcp.njcp_277_19&pmid=33851684&sid=OVID:medline
+
+<905>
+Unique Identifier
+ 33844250
+Title
+ Correlation of monocyte/HDL ratio (MHR) with inflammatory parameters in obese patients diagnosed with polycystic ovary syndrome.
+Source
+ Ginekologia Polska. 92(8):537-543, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Herkiloglu D; Gokce S
+Author NameID
+ Herkiloglu, Dilsad; ORCID: https://orcid.org/0000-0001-9915-3469
+Authors Full Name
+ Herkiloglu, Dilsad; Gokce, Sefik.
+Institution
+ Herkiloglu, Dilsad. Istanbul Yeni Yuzyil University Department Of Obstetrics And Gynecology, Istanbul, Turkey. dilsadherkiloglu@hotmail.com.
+ Gokce, Sefik. Istanbul Yeni Yuzyil University Department Of Obstetrics And Gynecology, Istanbul, Turkey.
+MeSH Subject Headings
+ Biomarkers
+ Cholesterol, HDL
+ Female
+ Humans
+ Lymphocytes
+ Monocytes
+ Obesity/co [Complications]
+ Polycystic Ovary Syndrome/co [Complications]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ *Polycystic Ovary Syndrome
+Keyword Heading
+ PCOS
+ monocyte/HDL ratio
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Monocyte/high density lipprotein (HDL) ratio (MHR) has been reported to be associated with obesity and polycystic ovarian syndrome (PCOS). In this study, it was aimed to evaluate whether there is a relationship between PCOS and MHR and inflammatory parameters, to investigate the relationship level of MHR and lymphocyte/monocyte ratio (LMR), which are easily accessible inflammatory and oxidative stress markers, with obese women with PCOS, and to determine the usability of MHR as a predictive marker for PCOS.
+
+ MATERIAL AND METHODS: The study included 64 PCOS-patients who were admitted to Gynecology clinics and 52 healthy women.
+
+ RESULTS: The mean MHR (12.5 +/- 4.6) in the PCOS group was significantly higher than the control group (10.4 +/- 4.0) (p = 0.01). In the examination performed by combining the groups PCOS and obesity status, the mean MHR value in the PCOS-obese group was significantly higher than all the other groups (p = 0.004). In the ROC analysis, the threshold value of 10.1 for MHR was found to have a sensitivity of 84.8% and specificity of 58.5% in determining the association between PCOS and obesity (AUC: 0.721; p < 0.001; LB: 0.628; UB: 0.814; CI 95%). Accordingly, the rate of those with MHR level of 10.1 and above was significantly higher in the PCOS group compared to the control group (67.2% vs 40.4%) (p = 0.001). In the logistic regression analysis, the determination is increased by 3,026 times (odds ratio; 1.401-6.535) in predicting the presence of PCOS in those with MHR value of 10.1 and above, and 7,576 times (Odds ratio; 2.652-21.646) in predicting the presence of PCOS + obesity was found to be. Correlation analysis in PCOS patients revealed that the MHR value was negatively correlated with age (p = 0.001; r = -0.412), LMR (p = 0.003; r = -0.377), and total cholesterol [p = 0.018; correlation coefficient (r) = -0.302].
+
+ CONCLUSIONS: This study findings showed that MHR level is significantly related to PCOS, and especially MHR values above 10.1 may be a significant predictive marker for PCOS. Our study findings also show that an association of PCOS and obesity is a very important trigger on MHR.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.5603%2fGP.a2020.0191
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Herkiloglu&issn=0017-0011&title=Ginekologia+Polska&atitle=Correlation+of+monocyte%2FHDL+ratio+%28MHR%29+with+inflammatory+parameters+in+obese+patients+diagnosed+with+polycystic+ovary+syndrome.&volume=92&issue=8&spage=537&epage=543&date=2021&doi=10.5603%2FGP.a2020.0191&pmid=33844250&sid=OVID:medline
+
+<906>
+Unique Identifier
+ 33838097
+Title
+ Screening for asymptomatic diabetes and metabolic comorbidities in pediatric patients during therapy for acute lymphoblastic leukemia.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 34(5):627-632, 2021 May 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Larouche V; Bellavance C; Tibout P; Bergeron S; Simonyan D; Gagne J
+Author NameID
+ Larouche, Valerie; ORCID: https://orcid.org/0000-0002-9773-0995
+Authors Full Name
+ Larouche, Valerie; Bellavance, Caroline; Tibout, Pauline; Bergeron, Sebastien; Simonyan, David; Gagne, Julie.
+Institution
+ Larouche, Valerie. Department of Pediatric Hematology-Oncology, CHU de Quebec-Universite Laval, Quebec, Canada.
+ Bellavance, Caroline. Faculty of Medicine, Universite Laval, Quebec, Canada.
+ Tibout, Pauline. Department of Pediatric, CHU de Quebec-Universite Laval, Quebec, Canada.
+ Bergeron, Sebastien. Department of Pediatric, CHU de Quebec-Universite Laval, Quebec, Canada.
+ Simonyan, David. Clinical and Evaluative Research Platform, Research Center, CHU de Quebec-Universite Laval, Quebec, Canada.
+ Gagne, Julie. Department of Pediatric, CHU de Quebec-Universite Laval, Quebec, Canada.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Child
+ Child, Preschool
+ Comorbidity
+ *Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/ep [Epidemiology]
+ Diabetes Mellitus/et [Etiology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Hyperglycemia/di [Diagnosis]
+ Hyperglycemia/ep [Epidemiology]
+ Hyperglycemia/et [Etiology]
+ Infant
+ Infant, Newborn
+ Male
+ *Mass Screening/mt [Methods]
+ *Metabolic Diseases/di [Diagnosis]
+ Metabolic Diseases/ep [Epidemiology]
+ Metabolic Diseases/et [Etiology]
+ Obesity/pp [Physiopathology]
+ *Precursor Cell Lymphoblastic Leukemia-Lymphoma/co [Complications]
+ Precursor Cell Lymphoblastic Leukemia-Lymphoma/pa [Pathology]
+ Precursor Cell Lymphoblastic Leukemia-Lymphoma/th [Therapy]
+ Prognosis
+ Prospective Studies
+ Young Adult
+Keyword Heading
+ chemotherapy
+ children
+ hyperglycemia
+ leukemia
+ metabolic complications
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Chronic metabolic disturbances related to cancer treatment are well reported among survivors of pediatric acute lymphoblastic leukemia (ALL). However, few studies have investigated the incidence of these complications during the phase of chemotherapy. We evaluated the incidence of acute metabolic complications occurring during therapy in our cohort of patients diagnosed with ALL.
+
+ METHODS: A prospective study involving 50 ALL pediatric patients diagnosed and treated between 2012 and 2016 in our oncology unit. We collected weight, blood pressure, fasting plasma glucose and hemoglobin A1C (HBA1c) levels during the two years of therapy.
+
+ RESULTS: Obesity and overweight occurred in 43 and 25%, respectively among patients and have been reached at 12 months of chemotherapy. About 26% of the patients developed high blood pressure and 14% experienced hyperglycemias without meeting diabetes criteria. There was a significant decrease of HBA1c levels between the beginning and the end of therapy (p<0.0001).
+
+ CONCLUSIONS: Increase of body mass index in our ALL pediatric patients occurred during the first months of therapy and plateaued after a year of treatment. We should target this population for early obesity prevention. HbA1c levels measured during therapy did not reveal diabetes criteria. Hence, fasting blood glucose levels are sufficient to monitor ALL pediatric patients' glycemia. Copyright © 2021 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1515%2fjpem-2020-0457
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Larouche&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Screening+for+asymptomatic+diabetes+and+metabolic+comorbidities+in+pediatric+patients+during+therapy+for+acute+lymphoblastic+leukemia.&volume=34&issue=5&spage=627&epage=632&date=2021&doi=10.1515%2Fjpem-2020-0457&pmid=33838097&sid=OVID:medline
+
+<907>
+Unique Identifier
+ 33836983
+Title
+ Managing cardiometabolic risk factors across a woman's lifespan: A lipidologist's perspective. [Review]
+Source
+ Journal of Clinical Lipidology. 15(3):423-430, 2021 May-Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gianos E; Karalis DG; Gaballa D; Paparodis R; Mintz GL; Balakrishnan M; Myerson M; Brinton EA; Wild RA
+Authors Full Name
+ Gianos, Eugenia; Karalis, Dean G; Gaballa, Dianna; Paparodis, Rodis; Mintz, Guy L; Balakrishnan, Maya; Myerson, Merle; Brinton, Eliot A; Wild, Robert A.
+Institution
+ Gianos, Eugenia. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY USA; Lenox Hill Hospital, Northwell Health, Division of Cardiology USA. Electronic address: EGianos@northwell.edu.
+ Karalis, Dean G. Thomas Jefferson University Sidney Kimmel Medical College, Department of Cardiology USA.
+ Gaballa, Dianna. Lenox Hill Hospital, Northwell Health, Division of Cardiology USA.
+ Paparodis, Rodis. University of Toledo College of Medicine and Life Sciences, Center for Diabetes and Endocrine Research (CeDER) USA.
+ Mintz, Guy L. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY USA; North Shore University Hospital, Northwell Health, Manhasset, NY USA.
+ Balakrishnan, Maya. Baylor College of Medicine, Section of Gastroenterology and Hepatology USA.
+ Myerson, Merle. Dartmouth-Hitchcock Medical Center, Division of Cardiology USA.
+ Brinton, Eliot A. Utah Lipid Center, Salt Lake City, USA.
+ Wild, Robert A. University of Oklahoma Health Sciences Center, Department of Obstetrics and Gynecology USA.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ *Cardiometabolic Risk Factors
+ *Cardiovascular Diseases/co [Complications]
+ Cardiovascular Diseases/pp [Physiopathology]
+ Female
+ Humans
+ Life Style
+ Menopause
+ Obesity/co [Complications]
+ Risk Reduction Behavior
+Keyword Heading
+ Adverse pregnancy outcomes (APO)
+ Cardiometabolic
+ Lipidology
+ Non-alcoholic fatty liver disease (NALFD)
+ Polycystic ovarian syndrome (PCOS)
+ Women's cardiovascular health
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ A recent rise in atherosclerotic cardiovascular disease (ASCVD) mortality in women warrants a heightened focus on the cardiometabolic risk factors that are closely tied to increasing trends in obesity and suboptimal lifestyle. Polycystic ovarian syndrome (PCOS), adverse pregnancy outcomes (APOs) and nonalcoholic fatty liver disease (NAFLD) are often manifestations of cardiometabolic disease that convey cardiovascular risk requiring recognition foremost, as well as a targeted approach to treatment. Similarly, menopause is a time to reflect on a woman's cardiovascular risk as multiple cardiometabolic changes occur during this time. Contraceptives and menopausal replacement therapy (MRT) should be considered along with a woman's individual thrombotic and cardiovascular risk. Clinicians should be attuned to cardiometabolic risk factors throughout a woman's lifespan and familiar with strategies to reduce cardiovascular risk. Copyright © 2021. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.jacl.2021.03.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gianos&issn=1933-2874&title=Journal+of+Clinical+Lipidology&atitle=Managing+cardiometabolic+risk+factors+across+a+woman%27s+lifespan%3A+A+lipidologist%27s+perspective.&volume=15&issue=3&spage=423&epage=430&date=2021&doi=10.1016%2Fj.jacl.2021.03.005&pmid=33836983&sid=OVID:medline
+
+<908>
+Unique Identifier
+ 33836830
+Title
+ Ethnic Specific body fat percent prediction equation as surrogate marker of obesity in Ethiopian adults.
+Source
+ Journal of Health, Population & Nutrition. 40(1):17, 2021 04 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sinaga M; Sinaga Teshome M; Yemane T; Tegene E; Lindtsrom D; Belachew T
+Authors Full Name
+ Sinaga, Makeda; Sinaga Teshome, Melese; Yemane, Tilhun; Tegene, Elsah; Lindtsrom, David; Belachew, Tefera.
+Institution
+ Sinaga, Makeda. Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. makedasinaga@gmail.com.
+ Sinaga Teshome, Melese. Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia.
+ Yemane, Tilhun. Department of Laboratory and Biomedical Sciences, Faculty of Health Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.
+ Tegene, Elsah. Department of Internal Medicine, Faculty of Medicine, Institute of Health, Jimma University, Jimma, Ethiopia.
+ Lindtsrom, David. Department of Sociology, Brown University, Providence, USA.
+ Belachew, Tefera. Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia.
+MeSH Subject Headings
+ *Adipose Tissue
+ Adult
+ Anthropometry/mt [Methods]
+ Biomarkers/an [Analysis]
+ *Black People/sn [Statistics & Numerical Data]
+ Body Composition
+ *Clinical Decision Rules
+ Cross-Sectional Studies
+ Ethiopia/eh [Ethnology]
+ Female
+ Humans
+ Male
+ *Obesity/di [Diagnosis]
+ *Obesity/eh [Ethnology]
+ White People/sn [Statistics & Numerical Data]
+ Young Adult
+Keyword Heading
+ Adults
+ Body fat percent
+ Equation
+ Ethiopia
+ Prediction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Application of advanced body composition measurement methods is not practical in developing countries context due to cost and unavailability of facilities. This study generated ethnic specific body fat percent prediction equation for Ethiopian adults using appropriate data.
+
+ METHODS: A cross-sectional study was carried ifrom February to April 2015 among 704 randomly selected adult employees of Jimma University. Ethnic specific Ethiopian body fat percent (BF%) prediction equation was developed using a multivariable linear regression model with measured BF% as dependent variable and age, sex, and body mass index as predictor variables. Agreement between fat percent measured using air displacement plethysmography and body fat percent estimated using Caucasian prediction equations was determined using Bland Altman plot.
+
+ RESULTS: Comparison of ADP measured and predicted BF% showed that Caucasian prediction equation underestimated body fat percent among Ethiopian adults by 6.78% (P < 0.0001). This finding is consistent across all age groups and ethnicities in both sexes. Bland Altman plot did not show agreement between ADP and Caucasian prediction equation (mean difference = 6.7825) and some of the points are outside 95% confidence interval. The caucasian prediction equation significantly underestimates body fat percent in Ethiopian adults, which is consistent across all ethnic groups in the sample. The study developed Ethnic specific BF% prediction equations for Ethiopian adults.
+
+ CONCLUSION: The Caucasian prediction equation significantly underestimates body fat percent among Ethiopian adults regardless of ethnicity. Ethiopian ethnic-specific prediction equation can be used as a very simple, cheap, and cost-effective alternative for estimating body fat percent among Ethiopian adults for health care provision in the prevention of obesity and related morbidities and for research purposes.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1186%2fs41043-021-00224-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sinaga&issn=1606-0997&title=Journal+of+Health%2C+Population+%26+Nutrition&atitle=Ethnic+Specific+body+fat+percent+prediction+equation+as+surrogate+marker+of+obesity+in+Ethiopian+adults.&volume=40&issue=1&spage=17&epage=&date=2021&doi=10.1186%2Fs41043-021-00224-3&pmid=33836830&sid=OVID:medline
+
+<909>
+Unique Identifier
+ 33829394
+Title
+ Negative associations of morning serum cortisol levels with obesity: the Henan rural cohort study.
+Source
+ Journal of Endocrinological Investigation. 44(12):2581-2592, 2021 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fan K; Wei D; Liu X; He Y; Tian H; Tu R; Liu P; Nie L; Zhang L; Qiao D; Liu X; Hou J; Li L; Wang C; Huo W; Zhang G; Mao Z
+Author NameID
+ Mao, Z; ORCID: http://orcid.org/0000-0001-5171-1169
+Authors Full Name
+ Fan, K; Wei, D; Liu, X; He, Y; Tian, H; Tu, R; Liu, P; Nie, L; Zhang, L; Qiao, D; Liu, X; Hou, J; Li, L; Wang, C; Huo, W; Zhang, G; Mao, Z.
+Institution
+ Fan, K. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Wei, D. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Liu, X. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ He, Y. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Tian, H. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Tu, R. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Liu, P. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Nie, L. Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Zhang, L. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Qiao, D. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Liu, X. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Hou, J. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Li, L. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Wang, C. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Huo, W. Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
+ Zhang, G. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China. zgy@zzu.edu.cn.
+ Mao, Z. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China. maozhr@gmail.com.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Causality
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Hydrocortisone/an [Analysis]
+ Hydrocortisone/bl [Blood]
+ *Hydrocortisone
+ Intra-Abdominal Fat/me [Metabolism]
+ Intra-Abdominal Fat/pa [Pathology]
+ *Intra-Abdominal Fat
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ ROC Curve
+ Risk Assessment/mt [Methods]
+ Risk Factors
+ Rural Population/sn [Statistics & Numerical Data]
+ Waist Circumference
+Keyword Heading
+ Cortisol
+ Obesity
+ ROC curve
+ Restrictive cubic splines
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: To evaluate the associations of morning serum cortisol levels with obesity defined by different indices in Chinese rural populations.
+
+ MATERIALS AND METHODS: A cross-sectional study was performed including 6198 participants (2566 males and 3632 females). Serum cortisol was collected in morning and quantified by liquid chromatography-tandem mass spectrometry. Obesity was defined by body mass index (BMI), body fat percentage (BFP), waist-to-height ratio (WHtR), waist circumference (WC), visceral fat index (VFI) and waist-to-hip ratio (WHR). Both multivariable liner regression, logistic regression and restrictive cubic splines models were used to estimate the gender-specific relationships between cortisol levels and obesity defined by different indices, respectively.
+
+ RESULTS: After adjusting for potential confounders, serum cortisol was negatively associated with different obesity measures, except obese females defined by BFP (for instance, overall obesity defined by BMI, Quartile 4 vs. Quartile 1, odds ratio (OR) = 0.25, 95% confidence interval (CI):0.15, 0.41 in males, and OR = 0.58, 95% CI: 0.42,0.80 in females, central obesity defined by WC, OR = 0.52, 95% CI:0.39,0.69 in males and OR = 0.63, 95% CI:0.51,0.77 in females). Similarly, restrictive cubic splines showed the nonlinear relationship between high levels of cortisol and different obesity indices. Furthermore, ROC curve analysis indicated that cortisol could improve the discrimination of model with common biomarkers.
+
+ CONCLUSION: Morning serum cortisol were negatively related to obesity defined by different indices in Chinese rural populations. In addition, cortisol could be as a biomarker for prediction of obesity in males. Copyright © 2021. Italian Society of Endocrinology (SIE).
+Registry Number/Name of Substance
+ 0 (Biomarkers). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs40618-021-01558-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fan&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Negative+associations+of+morning+serum+cortisol+levels+with+obesity%3A+the+Henan+rural+cohort+study.&volume=44&issue=12&spage=2581&epage=2592&date=2021&doi=10.1007%2Fs40618-021-01558-9&pmid=33829394&sid=OVID:medline
+
+<910>
+Unique Identifier
+ 33829335
+Title
+ Predictive scoring system for advanced liver fibrosis in Japanese patients with severe obesity.
+Source
+ Surgery Today. 51(9):1513-1520, 2021 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nikai H; Sasaki A; Umemura A; Takahashi N; Nitta H; Akasaka R; Kakisaka K; Kuroda H; Ishida K; Takikawa Y
+Authors Full Name
+ Nikai, Haruka; Sasaki, Akira; Umemura, Akira; Takahashi, Naoto; Nitta, Hiroyuki; Akasaka, Risaburo; Kakisaka, Keisuke; Kuroda, Hidekatsu; Ishida, Kazuyuki; Takikawa, Yasuhiro.
+Institution
+ Nikai, Haruka. Department of Surgery, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
+ Sasaki, Akira. Department of Surgery, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan. sakira@iwate-med.ac.jp.
+ Umemura, Akira. Department of Surgery, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
+ Takahashi, Naoto. Department of Surgery, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
+ Nitta, Hiroyuki. Department of Surgery, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
+ Akasaka, Risaburo. Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
+ Kakisaka, Keisuke. Division of Hepatology, Department of Internal Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
+ Kuroda, Hidekatsu. Division of Hepatology, Department of Internal Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
+ Ishida, Kazuyuki. Department of Pathology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
+ Takikawa, Yasuhiro. Division of Hepatology, Department of Internal Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
+MeSH Subject Headings
+ Asian People
+ Biomarkers/bl [Blood]
+ Biopsy
+ Collagen Type IV/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Forecasting
+ Gastrectomy/mt [Methods]
+ Humans
+ Intraoperative Period
+ Laparoscopy/mt [Methods]
+ Liver/pa [Pathology]
+ Liver Cirrhosis/co [Complications]
+ *Liver Cirrhosis/di [Diagnosis]
+ *Liver Cirrhosis/et [Etiology]
+ Liver Cirrhosis/pa [Pathology]
+ Logistic Models
+ *Obesity/co [Complications]
+ Obesity/su [Surgery]
+ Predictive Value of Tests
+ Prevalence
+ *Research Design
+ Severity of Illness Index
+Keyword Heading
+ Bariatric surgery
+ Laparoscopic sleeve gastrectomy
+ Liver fibrosis
+ Morbid obesity
+ Nonalcoholic steatohepatitis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: The aim of this study was to examine the predictive scoring system of advanced liver fibrosis in severely obese Japanese patients.
+
+ METHODS: Seventy-two patients underwent laparoscopic sleeve gastrectomy and intraoperative liver biopsies. We classified these patients into two groups: Brunt stage >= 2 (advanced fibrosis) and 0/1 (none/mild fibrosis). A logistic regression analysis was performed to identify the predictors of advanced fibrosis.
+
+ RESULTS: Sixteen patients had advanced fibrosis, while 56 had no/mild fibrosis. The prevalence of type 2 diabetes mellitus (T2DM) in advanced fibrosis group was significantly higher than in none/mild fibrosis. An univariate analysis of the factors predicting advanced fibrosis showed significant differences in AST/ALT ratio, serum insulin levels, HOMA-IR, and type IV collagen 7S in the T2DM group. According to a multivariate analysis, type IV collagen 7S was an independent predictor and the cutoff value was 5.6 ng/mL. We created a flow chart; high risk (T2DM and type IV collagen 7S >= 5.6 ng/mL), moderate risk (T2DM and type IV collagen 7S < 5.6 ng/mL), and low risk (non-DM). For those at high risk, the sensitivity, specificity, positive predictive value, and negative predictive value were 56.2%, 94.4%, 75.0%, and 87.9%, respectively.
+
+ CONCLUSION: This classification system has the potential to accurately categorize the risk of liver fibrosis. Copyright © 2021. Springer Nature Singapore Pte Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Collagen Type IV).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs00595-021-02266-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nikai&issn=0941-1291&title=Surgery+Today&atitle=Predictive+scoring+system+for+advanced+liver+fibrosis+in+Japanese+patients+with+severe+obesity.&volume=51&issue=9&spage=1513&epage=1520&date=2021&doi=10.1007%2Fs00595-021-02266-w&pmid=33829335&sid=OVID:medline
+
+<911>
+Unique Identifier
+ 33815359
+Title
+ Adipocyte Fatty Acid-Binding Protein, Cardiovascular Diseases and Mortality. [Review]
+Source
+ Frontiers in Immunology. 12:589206, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee CH; Lui DTW; Lam KSL
+Authors Full Name
+ Lee, Chi-Ho; Lui, David T W; Lam, Karen S L.
+Institution
+ Lee, Chi-Ho. Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
+ Lee, Chi-Ho. State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, Hong Kong.
+ Lui, David T W. Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
+ Lam, Karen S L. Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
+ Lam, Karen S L. State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, Hong Kong.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipokines/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Cardiometabolic Risk Factors
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases/me [Metabolism]
+ Cardiovascular Diseases/mo [Mortality]
+ Disease Management
+ *Disease Susceptibility
+ *Fatty Acid-Binding Proteins/ge [Genetics]
+ *Fatty Acid-Binding Proteins/me [Metabolism]
+ Gene Expression Regulation
+ Humans
+ Insulin Resistance
+ Molecular Targeted Therapy
+ Mortality
+ Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Prognosis
+Keyword Heading
+ adipocyte fatty acid-binding protein
+ adipokine
+ cardiovascular disease
+ inflammation
+ mortality
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ It has been increasingly recognized that inflammation plays an important role in the pathogenesis of cardiovascular disease (CVD). In obesity, adipose tissue inflammation, especially in the visceral fat depots, contributes to systemic inflammation and promotes the development of atherosclerosis. Adipocyte fatty acid-binding protein (AFABP), a lipid chaperone abundantly secreted from the adipocytes and macrophages, is one of the key players mediating this adipose-vascular cross-talk, in part via its interaction with c-Jun NH2-terminal kinase (JNK) and activator protein-1 (AP-1) to form a positive feedback loop, and perpetuate inflammatory responses. In mice, selective JNK inactivation in the adipose tissue significantly reduced the expression of AFABP in their adipose tissue, as well as circulating AFABP levels. Importantly, fat transplant experiments showed that adipose-specific JNK inactivation in the visceral fat was sufficient to protect mice with apoE deficiency from atherosclerosis, with the beneficial effects attenuated by the continuous infusion of recombinant AFABP, supporting the role of AFABP as the link between visceral fat inflammation and atherosclerosis. In humans, raised circulating AFABP levels are associated with incident metabolic syndrome, type 2 diabetes and CVD, as well as non-alcoholic steatohepatitis, diabetic nephropathy and adverse renal outcomes, all being conditions closely related to inflammation and enhanced CV mortality. Collectively, these clinical data have provided support to AFABP as an important adipokine linking obesity, inflammation and CVD. This review will discuss recent findings on the role of AFABP in CVD and mortality, the possible underlying mechanisms, and pharmacological inhibition of AFABP as a potential strategy to combat CVD. Copyright © 2021 Lee, Lui and Lam.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (FABP4 protein, human). 0 (Fatty Acid-Binding Proteins).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3389%2ffimmu.2021.589206
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Adipocyte+Fatty+Acid-Binding+Protein%2C+Cardiovascular+Diseases+and+Mortality.&volume=12&issue=&spage=589206&epage=&date=2021&doi=10.3389%2Ffimmu.2021.589206&pmid=33815359&sid=OVID:medline
+
+<912>
+Unique Identifier
+ 33814235
+Title
+ CA.ME.LI.A. An epidemiological study on the prevalence of CArdiovascular, MEtabolic, LIver and Autoimmune diseases in Northern Italy.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(5):1416-1426, 2021 05 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bignotto M; Dei Cas M; Paroni R; Bianco E; Zermiani P; Gangale MG; Zadro V; Maregatti M; Piagnani A; Russo A; Baldassarre D; Folli F; Battezzati PM; Zuin M
+Authors Full Name
+ Bignotto, Monica; Dei Cas, Michele; Paroni, Rita; Bianco, Elena; Zermiani, Paola; Gangale, Maria G; Zadro, Valentina; Maregatti, Margherita; Piagnani, Alessandra; Russo, Antonio; Baldassarre, Damiano; Folli, Franco; Battezzati, Pier Maria; Zuin, Massimo.
+Institution
+ Bignotto, Monica. Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
+ Dei Cas, Michele. Clinical Biochemistry and Mass Spectrometry, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
+ Paroni, Rita. Clinical Biochemistry and Mass Spectrometry, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
+ Bianco, Elena. Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
+ Zermiani, Paola. Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
+ Gangale, Maria G. ASST Ovest Milanese, via Papa Giovanni Paolo II, Legnano, Milan, Italy.
+ Zadro, Valentina. Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
+ Maregatti, Margherita. Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
+ Piagnani, Alessandra. Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy.
+ Russo, Antonio. Epidemiology Unit, Agency for Health Protection of Milan, Corso Italia 19, 20122, Milan, Italy.
+ Baldassarre, Damiano. Department of Medical Biotechnology and Translational Medicine, Universita degli Studi di Milano, Milan, Italy; Centro Cardiologico Monzino, IRCCS, Milan, Italy.
+ Folli, Franco. Endocrinology and Metabolism, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy; ASST Santi Paolo e Carlo, University Hospital San Paolo, via A. Di Rudini', Milan, Italy. Electronic address: franco.folli@unimi.it.
+ Battezzati, Pier Maria. Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy; ASST Santi Paolo e Carlo, University Hospital San Paolo, via A. Di Rudini', Milan, Italy.
+ Zuin, Massimo. Liver and Gastroenterology Unit, Department of Health Sciences, Universita' degli Studi di Milano, Milan, Italy; ASST Santi Paolo e Carlo, University Hospital San Paolo, via A. Di Rudini', Milan, Italy. Electronic address: massimo.zuin@unimi.it.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Autoimmune Diseases/bl [Blood]
+ Autoimmune Diseases/di [Diagnosis]
+ *Autoimmune Diseases/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ C-Reactive Protein/an [Analysis]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Cross-Sectional Studies
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/ep [Epidemiology]
+ Female
+ Glucose Metabolism Disorders/bl [Blood]
+ Glucose Metabolism Disorders/ep [Epidemiology]
+ Humans
+ Italy/ep [Epidemiology]
+ Lipids/bl [Blood]
+ Liver Diseases/bl [Blood]
+ Liver Diseases/di [Diagnosis]
+ *Liver Diseases/ep [Epidemiology]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ Time Factors
+ Young Adult
+ gamma-Glutamyltransferase/bl [Blood]
+Keyword Heading
+ Cardiovascular risk
+ Diabetes
+ Epidemiology
+ Liver disease
+ Metabolic syndrome
+ Obesity
+ Study population
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: CA.ME.LI.A (CArdiovascular risks, MEtabolic syndrome, LIver and Autoimmune disease) is a cross-sectional, epidemiological study performed between 2009-2011 in Abbiategrasso (Milan, Italy) to estimate the prevalence of cardiovascular risk factors, metabolic syndrome, liver and autoimmune diseases in the general adult population. This report focuses on the description and presentation of baseline characteristics of the population.
+
+ METHODS AND RESULTS: Citizens were randomly selected from the city electoral registers (n = 30903), yielding a sample of 2554 subjects (M = 1257, F = 1297; age, 47 +/- 15 yrs; range 18-77 yrs). Men had higher prevalence of overweight or obesity (60.8% vs 41.6%; p < 0.0001) and greater thickness of visceral adipose tissue (40 +/- 19 vs 27 +/- 17 mm; p < 0.0001); no gender difference was found in subcutaneous adipose tissue thickness. Men also showed higher levels of serum triglycerides, gamma-GT, fasting blood glucose, insulin and Homa-IR Index, while HDL, CRP, and prevalence of elevated (>5.0 mg/L) CRP were lower. Compared to normal weight men, risk-ratio (RR) of CRP elevation was 1.32 (ns) in overweight and 2.68 (p < 0.0001) in obese subjects. The corresponding figures in females were 2.68 (p < 0.0001) and 5.18 (p < 0.0001). Metabolic syndrome was more frequent in men (32.7% vs 14.5%; RR: 2.24, p < 0.0001). Interadventitia common carotid artery diameter was higher in men and increased with age and BMI.
+
+ CONCLUSIONS: The present study reports on the overall characteristics of a large population from Northern Italy. It aims to identify the associations among cardiovascular risk factors to prevent their development and progression, improve healthy lifestyle and identify subjects liable to pharmacological interventions. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). 9007-41-4 (C-Reactive Protein). EC 2-3-2-2 (gamma-Glutamyltransferase). EC 2-3-2-2 (gamma-glutamyltransferase, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.numecd.2021.02.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bignotto&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=CA.ME.LI.A.+An+epidemiological+study+on+the+prevalence+of+CArdiovascular%2C+MEtabolic%2C+LIver+and+Autoimmune+diseases+in+Northern+Italy.&volume=31&issue=5&spage=1416&epage=1426&date=2021&doi=10.1016%2Fj.numecd.2021.02.001&pmid=33814235&sid=OVID:medline
+
+<913>
+Unique Identifier
+ 33808883
+Title
+ Clinical Usefulness of Anthropometric Indices to Predict the Presence of Prediabetes. Data from the ILERVAS Cohort.
+Source
+ Nutrients. 13(3), 2021 Mar 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sanchez M; Sanchez E; Bermudez-Lopez M; Torres G; Farras-Salles C; Pamplona R; Castro-Boque E; Valdivielso JM; Purroy F; Martinez-Alonso M; Godoy P; Mauricio D; Fernandez E; Hernandez M; Rius F; Lecube A; On Behalf Of The Ilervas Project Collaborators
+Author NameID
+ Sanchez, Enric; ORCID: https://orcid.org/0000-0001-7345-1601
+ Pamplona, Reinald; ORCID: https://orcid.org/0000-0003-4337-6107
+ Castro-Boque, Eva; ORCID: https://orcid.org/0000-0002-1013-0007
+ Valdivielso, Jose Manuel; ORCID: https://orcid.org/0000-0003-1343-0184
+ Mauricio, Didac; ORCID: https://orcid.org/0000-0002-2868-0250
+ Hernandez, Marta; ORCID: https://orcid.org/0000-0003-1237-298X
+ Rius, Ferran; ORCID: https://orcid.org/0000-0002-0916-957X
+ Lecube, Albert; ORCID: https://orcid.org/0000-0001-9684-0183
+Authors Full Name
+ Sanchez, Marta; Sanchez, Enric; Bermudez-Lopez, Marcelino; Torres, Gerard; Farras-Salles, Cristina; Pamplona, Reinald; Castro-Boque, Eva; Valdivielso, Jose Manuel; Purroy, Francisco; Martinez-Alonso, Montserrat; Godoy, Pere; Mauricio, Didac; Fernandez, Elvira; Hernandez, Marta; Rius, Ferran; Lecube, Albert; On Behalf Of The Ilervas Project Collaborators.
+Institution
+ Sanchez, Marta. Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Rovira Roure 80, 25198 Lleida, Spain.
+ Sanchez, Enric. Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Rovira Roure 80, 25198 Lleida, Spain.
+ Bermudez-Lopez, Marcelino. Vascular and Renal Translational Research Group, IRBLleida, RedinRen-ISCIII, University of Lleida, 25198 Lleida, Spain.
+ Torres, Gerard. Respiratory Department, University Hospital Arnau de Vilanova-Santa Maria, Translational Research in Respiratory Medicine, IRBLleida, University of Lleida, 25198 Lleida, Spain.
+ Torres, Gerard. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Farras-Salles, Cristina. Applied Epidemiology Research Group, IRBLleida, 25007 Lleida, Spain.
+ Farras-Salles, Cristina. Institut Catala de la Salut, Unitat de Suport a la Recerca Lleida, Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), 25007 Lleida, Spain.
+ Pamplona, Reinald. Experimental Medicine Department, IRBLleida, University of Lleida, 25198 Lleida, Spain.
+ Castro-Boque, Eva. Vascular and Renal Translational Research Group, IRBLleida, RedinRen-ISCIII, University of Lleida, 25198 Lleida, Spain.
+ Valdivielso, Jose Manuel. Vascular and Renal Translational Research Group, IRBLleida, RedinRen-ISCIII, University of Lleida, 25198 Lleida, Spain.
+ Purroy, Francisco. Stroke Unit, University Hospital Arnau de Vilanova, Clinical Neurosciences Group, IRBLleida, University of Lleida, 25198 Lleida, Spain.
+ Martinez-Alonso, Montserrat. Systems Biology and Statistical Methods for Biomedical Research Group, Biostatistics Unit, IRBLleida, Universitat de Lleida, 25198 Lleida, Spain.
+ Godoy, Pere. Applied Epidemiology Research Group, IRBLleida, 25007 Lleida, Spain.
+ Mauricio, Didac. Department of Endocrinology and Nutrition, Hospital de la Sant Creu i Sant Pau, Sant Quinti, 08041 Barcelona, Spain.
+ Mauricio, Didac. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
+ Fernandez, Elvira. Vascular and Renal Translational Research Group, IRBLleida, RedinRen-ISCIII, University of Lleida, 25198 Lleida, Spain.
+ Hernandez, Marta. Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Rovira Roure 80, 25198 Lleida, Spain.
+ Rius, Ferran. Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Rovira Roure 80, 25198 Lleida, Spain.
+ Lecube, Albert. Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Rovira Roure 80, 25198 Lleida, Spain.
+MeSH Subject Headings
+ Adiposity
+ *Anthropometry/mt [Methods]
+ Biomarkers
+ Body Weight
+ Cohort Studies
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2
+ Female
+ Glycated Hemoglobin
+ Humans
+ Male
+ Obesity
+ Obesity, Abdominal
+ Overweight
+ *Prediabetic State/di [Diagnosis]
+ ROC Curve
+Keyword Heading
+ adiposity
+ body composition
+ glycated hemoglobin
+ obesity
+ prediabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Prediabetes is closely related to excess body weight and adipose distribution. For this reason, we aimed to assess and compare the diagnostic usefulness of ten anthropometric adiposity indices to predict prediabetes. Cross-sectional study with 8188 overweight subjects free of type 2 diabetes from the ILERVAS project (NCT03228459). Prediabetes was diagnosed by levels of glycated hemoglobin (HbA1c). Total body adiposity indices [BMI, Clinica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) and Deurenberg's formula] and abdominal adiposity (waist and neck circumferences, conicity index, waist to height ratio, Bonora's equation, A body shape index, and body roundness index) were calculated. The area under the receiver-operating characteristic (ROC) curve, the best cutoff and the prevalence of prediabetes around this value were calculated for every anthropometric index. All anthropometric indices other than the A body adiposity were higher in men and women with prediabetes compared with controls (p < 0.001 for all). In addition, a slightly positive correlation was found between indices and HbA1c in both sexes (r <= 0.182 and p <= 0.026 for all). None of the measures achieved acceptable levels of discrimination in ROC analysis (area under the ROC <= 0.63 for all). Assessing BMI, the prevalence of prediabetes among men increased from 20.4% to 36.2% around the cutoff of 28.2 kg/m2, with similar data among women (from 29.3 to 44.8% with a cutoff of 28.6 kg/m2). No lonely obesity index appears to be the perfect biomarker to use in clinical practice to detect individuals with prediabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fnu13031002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sanchez&issn=2072-6643&title=Nutrients&atitle=Clinical+Usefulness+of+Anthropometric+Indices+to+Predict+the+Presence+of+Prediabetes.+Data+from+the+ILERVAS+Cohort.&volume=13&issue=3&spage=&epage=&date=2021&doi=10.3390%2Fnu13031002&pmid=33808883&sid=OVID:medline
+
+<914>
+Unique Identifier
+ 33807567
+Title
+ Multivariate Statistical Approach for Nephrines in Women with Obesity.
+Source
+ Molecules. 26(5), 2021 Mar 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Robeva R; Nedyalkova M; Kirilov G; Elenkova A; Zacharieva S; Kudlak B; Jatkowska N; Simeonov V
+Author NameID
+ Kudlak, Blazej; ORCID: https://orcid.org/0000-0002-2237-2927
+ Jatkowska, Natalia; ORCID: https://orcid.org/0000-0001-8268-3287
+ Simeonov, Vasil; ORCID: https://orcid.org/0000-0003-1164-9561
+Authors Full Name
+ Robeva, Ralitsa; Nedyalkova, Miroslava; Kirilov, Georgi; Elenkova, Atanaska; Zacharieva, Sabina; Kudlak, Blazej; Jatkowska, Natalia; Simeonov, Vasil.
+Institution
+ Robeva, Ralitsa. Department of Endocrinology, Faculty of Medicine, Medical University-Sofia, USHATE "Acad. Iv. Penchev", 2, Zdrave Str., 1431 Sofia, Bulgaria.
+ Nedyalkova, Miroslava. Department of Inorganic Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia "St. Kl. Ohridski", 1164 Sofia, Bulgaria.
+ Kirilov, Georgi. Department of Endocrinology, Faculty of Medicine, Medical University-Sofia, USHATE "Acad. Iv. Penchev", 2, Zdrave Str., 1431 Sofia, Bulgaria.
+ Elenkova, Atanaska. Department of Endocrinology, Faculty of Medicine, Medical University-Sofia, USHATE "Acad. Iv. Penchev", 2, Zdrave Str., 1431 Sofia, Bulgaria.
+ Zacharieva, Sabina. Department of Endocrinology, Faculty of Medicine, Medical University-Sofia, USHATE "Acad. Iv. Penchev", 2, Zdrave Str., 1431 Sofia, Bulgaria.
+ Kudlak, Blazej. Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza, 80-233 Gdansk, Poland.
+ Jatkowska, Natalia. Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza, 80-233 Gdansk, Poland.
+ Simeonov, Vasil. Department of Analytical Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia "St. Kl. Ohridski", 1164 Sofia, Bulgaria.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/ur [Urine]
+ Cluster Analysis
+ Diabetes Mellitus, Type 2/ur [Urine]
+ Female
+ Humans
+ Metabolic Syndrome/ur [Urine]
+ *Metanephrine/ur [Urine]
+ Middle Aged
+ *Multivariate Analysis
+ *Normetanephrine/ur [Urine]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Obesity/ur [Urine]
+ Waist Circumference
+Keyword Heading
+ cluster analyses
+ diabetes
+ exploratory data analysis
+ hypertension
+ metanephrine
+ normetanephrine
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Catecholamines are physiological regulators of carbohydrate and lipid metabolism during stress, but their chronic influence on metabolic changes in obese patients is still not clarified. The present study aimed to establish the associations between the catecholamine metabolites and metabolic syndrome (MS) components in obese women as well as to reveal the possible hidden subgroups of patients through hierarchical cluster analysis and principal component analysis. The 24-h urine excretion of metanephrine and normetanephrine was investigated in 150 obese women (54 non diabetic without MS, 70 non-diabetic with MS and 26 with type 2 diabetes). The interrelations between carbohydrate disturbances, metabolic syndrome components and stress response hormones were studied. Exploratory data analysis was used to determine different patterns of similarities among the patients. Normetanephrine concentrations were significantly increased in postmenopausal patients and in women with morbid obesity, type 2 diabetes, and hypertension but not with prediabetes. Both metanephrine and normetanephrine levels were positively associated with glucose concentrations one hour after glucose load irrespectively of the insulin levels. The exploratory data analysis showed different risk subgroups among the investigated obese women. The development of predictive tools that include not only traditional metabolic risk factors, but also markers of stress response systems might help for specific risk estimation in obesity patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0J45DE6B88 (Normetanephrine). 5001-33-2 (Metanephrine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fmolecules26051393
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Robeva&issn=1420-3049&title=Molecules&atitle=Multivariate+Statistical+Approach+for+Nephrines+in+Women+with+Obesity.&volume=26&issue=5&spage=&epage=&date=2021&doi=10.3390%2Fmolecules26051393&pmid=33807567&sid=OVID:medline
+
+<915>
+Unique Identifier
+ 33795771
+Title
+ Association of pre- and early-pregnancy factors with the risk for gestational diabetes mellitus in a large Chinese population.
+Source
+ Scientific Reports. 11(1):7335, 2021 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhao M; Yang S; Hung TC; Zheng W; Su X
+Authors Full Name
+ Zhao, Min; Yang, Shuyu; Hung, Tzu Chieh; Zheng, Wenjie; Su, Xiaojie.
+Institution
+ Zhao, Min. Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xiamen University, No. 55, Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China. xmzmdyyy@163.com.
+ Zhao, Min. Computer Management Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China. xmzmdyyy@163.com.
+ Zhao, Min. National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, Fujian, China. xmzmdyyy@163.com.
+ Yang, Shuyu. Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xiamen University, No. 55, Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China.
+ Hung, Tzu Chieh. Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xiamen University, No. 55, Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China.
+ Zheng, Wenjie. Computer Management Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
+ Su, Xiaojie. Computer Management Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
+MeSH Subject Headings
+ Adult
+ Alanine Transaminase/bl [Blood]
+ Albumins/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ *Body Mass Index
+ Calibration
+ China/ep [Epidemiology]
+ Decision Making
+ *Diabetes, Gestational/di [Diagnosis]
+ *Diabetes, Gestational/pp [Physiopathology]
+ Female
+ Fetal Macrosomia/ep [Epidemiology]
+ Folic Acid/pd [Pharmacology]
+ Glucose Tolerance Test
+ Hospitals
+ Humans
+ Obesity/ep [Epidemiology]
+ Odds Ratio
+ Platelet Count
+ Pregnancy
+ Risk
+ Risk Factors
+ Young Adult
+Abstract
+ Gestational diabetes mellitus (GDM) has aroused wide public concern, as it affects approximately 1.8-25.1% of pregnancies worldwide. This study aimed to examine the association of pre-pregnancy demographic parameters and early-pregnancy laboratory biomarkers with later GDM risk, and further to establish a nomogram prediction model. This study is based on the big obstetric data from 10 "AAA" hospitals in Xiamen. GDM was diagnosed according to the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria. Data are analyzed using Stata (v14.1) and R (v3.5.2). Total 187,432 gestational women free of pre-pregnancy diabetes mellitus were eligible for analysis, including 49,611 women with GDM and 137,821 women without GDM. Irrespective of confounding adjustment, eight independent factors were consistently and significantly associated with GDM, including pre-pregnancy body mass index (BMI), pre-pregnancy intake of folic acid, white cell count, platelet count, alanine transaminase, albumin, direct bilirubin, and creatinine (p < 0.001). Notably, per 3 kg/m2 increment in pre-pregnancy BMI was associated with 22% increased risk [adjusted odds ratio (OR) 1.22, 95% confidence interval (CI) 1.21-1.24, p < 0.001], and pre-pregnancy intake of folic acid can reduce GDM risk by 27% (adjusted OR 0.73, 95% CI 0.69-0.79, p < 0.001). The eight significant factors exhibited decent prediction performance as reflected by calibration and discrimination statistics and decision curve analysis. To enhance clinical application, a nomogram model was established by incorporating age and above eight factors, and importantly this model had a prediction accuracy of 87%. Taken together, eight independent pre-/early-pregnancy predictors were identified in significant association with later GDM risk, and importantly a nomogram modeling these predictors has over 85% accuracy in early detecting pregnant women who will progress to GDM later.
+Registry Number/Name of Substance
+ 0 (Albumins). 0 (Biomarkers). 935E97BOY8 (Folic Acid). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-86818-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhao&issn=2045-2322&title=Scientific+Reports&atitle=Association+of+pre-+and+early-pregnancy+factors+with+the+risk+for+gestational+diabetes+mellitus+in+a+large+Chinese+population.&volume=11&issue=1&spage=7335&epage=&date=2021&doi=10.1038%2Fs41598-021-86818-7&pmid=33795771&sid=OVID:medline
+
+<916>
+Unique Identifier
+ 33790142
+Title
+ Effects of Age, Sex, and Obesity on N-Terminal Pro B-Type Natriuretic Peptide Concentrations in the General Population.
+Source
+ Circulation Journal. 85(5):647-654, 2021 04 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Choi HI; Lee MY; Oh BK; Lee SJ; Kang JG; Lee SH; Lee JY; Kim BJ; Kim BS; Kang JH; Sung KC
+Authors Full Name
+ Choi, Hyo-In; Lee, Mi Yeon; Oh, Byeong Kil; Lee, Seung Jae; Kang, Jeong Gyu; Lee, Sung Ho; Lee, Jong-Young; Kim, Byung Jin; Kim, Bum Soo; Kang, Jin Ho; Sung, Ki-Chul.
+Institution
+ Choi, Hyo-In. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Lee, Mi Yeon. Division of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Oh, Byeong Kil. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Lee, Seung Jae. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Kang, Jeong Gyu. Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Lee, Sung Ho. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Lee, Jong-Young. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Kim, Byung Jin. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Kim, Bum Soo. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Kang, Jin Ho. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+ Sung, Ki-Chul. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Female
+ Humans
+ Male
+ Natriuretic Peptide, Brain
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Peptide Fragments
+Keyword Heading
+ Age
+ N-Terminal pro B-type natriuretic peptide (NT-proBNP)
+ Obesity
+ Sex
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Data regarding complex relationships between age, sex, obesity and N-terminal pro B-type natriuretic peptide (NT-proBNP) remain scarce. Thus, we investigated sex-specific associations of obesity and NT-proBNP levels among adults in the general healthy population in Korea. Methods and Results: The associations of age, sex and obesity-associated parameters (waist circumference [WC], body mass index [BMI] and body weight) with NT-proBNP were analyzed in 39,937 healthy adult participants. Multivariable regression models adjusted for factors known to affect NT-proBNP were used to identify associations between NT-proBNP and obesity-related parameters. NT-proBNP levels were higher in females than males. Older age was also associated with higher NT-proBNP levels in the overall population (P<0.001). When accounting for age in multivariable linear regression models, there was a strong inverse association between WC, BMI, and NT-proBNP in females and a weaker inverse association in males, with a significant difference between the sexes (P interaction <0.001). After adjusting for the effects of WC and BMI on each other, abdominal obesity was associated with lower NT-proBNP levels in females but not males (P interaction <0.001).
+
+ CONCLUSIONS: In this large sample of young and healthy Asians, younger age, male sex, and increases in obesity-related parameters were related to lower levels of NT-proBNP. Further comprehensive studies are needed to understand the factors affecting NT-proBNP levels in different populations.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1253%2fcircj.CJ-20-1104
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Choi&issn=1346-9843&title=Circulation+Journal&atitle=Effects+of+Age%2C+Sex%2C+and+Obesity+on+N-Terminal+Pro+B-Type+Natriuretic+Peptide+Concentrations+in+the+General+Population.&volume=85&issue=5&spage=647&epage=654&date=2021&doi=10.1253%2Fcircj.CJ-20-1104&pmid=33790142&sid=OVID:medline
+
+<917>
+Unique Identifier
+ 33788827
+Title
+ Value of simple clinical parameters to predict insulin resistance among newly diagnosed patients with type 2 diabetes in limited resource settings.
+Source
+ PLoS ONE [Electronic Resource]. 16(3):e0248469, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wasana KGP; Attanayake AP; Weerarathna TP; Jayatilaka KAPW
+Author NameID
+ Weerarathna, Thilak Priyantha; ORCID: https://orcid.org/0000-0003-0047-6669
+Authors Full Name
+ Wasana, Keddagoda Gamage Piyumi; Attanayake, Anoja Priyadarshani; Weerarathna, Thilak Priyantha; Jayatilaka, Kamani Ayoma Perera Wijewardana.
+Institution
+ Wasana, Keddagoda Gamage Piyumi. Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
+ Attanayake, Anoja Priyadarshani. Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
+ Weerarathna, Thilak Priyantha. Department of Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
+ Jayatilaka, Kamani Ayoma Perera Wijewardana. Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ *Cholesterol, HDL/bl [Blood]
+ Cohort Studies
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Fasting/bl [Blood]
+ Female
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Sri Lanka/ep [Epidemiology]
+ Suburban Population
+ *Triglycerides/bl [Blood]
+ *Waist Circumference
+Abstract
+ BACKGROUND: Insulin resistance (IR) has been considered as a therapeutic target in the management of type 2 diabetes mellitus (T2DM). Readily available, simple and low cost measures to identify individuals with IR is of utmost importance for clinicians to plan optimal management strategies. Research on the associations between surrogate markers of IR and routine clinical and lipid parameters have not been carried out in Sri Lanka, a developing country with rising burden of T2DM with inadequate resources. Therefore, we aimed to study the utility of readily available clinical parameters such as age, body mass index (BMI), waist circumference (WC) and triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-C) in the fasting lipid profile in predicting IR in a cohort of patients with newly diagnosed T2DM in Sri Lanka.
+
+ METHODS AND FINDINGS: We conducted a community based cross sectional study involving of 147 patients (age 30-60 years) with newly diagnosed T2DM in a suburban locality in Galle district, Sri Lanka. Data on age, BMI, WC, fasting plasma glucose (FPG) concentration, fasting insulin concentration and serum lipid profile were collected from each subject. The indirect IR indices namely homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI) and McAuley index (MCA) were estimated. Both clinical and biochemical parameters across the lowest and the highest fasting insulin quartiles were compared using independent sample t-test. Linear correlation analysis was performed to assess the correlation between selected clinical parameters and indirect IR indices. The area under the receiver operating characteristic (ROC) curve was obtained to calculate optimal cut-off values for the clinical markers to differentiate IR. BMI (p<0.001) and WC (p = 0.01) were significantly increased whereas age (p = 0.06) was decreased and TG/HDL-C (p = 0.28) was increased across the insulin quartiles. BMI and WC were significantly correlated (p<0.05) with HOMA, QUICKI and MCA. Out of the clinical parameters, age showed a borderline significant correlation with QUICKI and TG/HDL-C showed a significant correlation only with MCA. The area under ROC of BMI was 0.728 (95% CI 0.648-0.809; p<0.001) and for WC, it was 0.646 (95% CI 0.559-0.734; p = 0.003). The optimized cut-off value for BMI and WC were 24.91 kg/m2 and 81.5 cm respectively to differentiate the patients with IR or ID. Study limitations include small sample size due to recruitment of patients only from a limited geographical locality of the country and not totally excluding of the possibility of inclusion of some patients with slowly progressive type 1 DM or Latent onset diabetes of adulthood from the study population.
+
+ CONCLUSIONS: The results revealed that there was a significant positive correlation between BMI, WC and HOMA while a significant negative correlation with QUICKI and MCA among the cohort of patients with newly diagnosed T2DM. The cut-off values of BMI and WC as 24.91 kg/m2 and 81.5 cm respectively could be used as simple clinical parameters to identify IR in newly diagnosed patients with T2DM. Our results could be beneficial in rational decision making in the management of newly diagnosed patients with T2DM in limited resource settings.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (Insulin). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1371%2fjournal.pone.0248469
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wasana&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Value+of+simple+clinical+parameters+to+predict+insulin+resistance+among+newly+diagnosed+patients+with+type+2+diabetes+in+limited+resource+settings.&volume=16&issue=3&spage=e0248469&epage=&date=2021&doi=10.1371%2Fjournal.pone.0248469&pmid=33788827&sid=OVID:medline
+
+<918>
+Unique Identifier
+ 33787913
+Title
+ The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults.
+Source
+ JAMA Network Open. 4(3):e212612, 2021 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fritz J; Brozek W; Concin H; Nagel G; Kerschbaum J; Lhotta K; Ulmer H; Zitt E
+Authors Full Name
+ Fritz, Josef; Brozek, Wolfgang; Concin, Hans; Nagel, Gabriele; Kerschbaum, Julia; Lhotta, Karl; Ulmer, Hanno; Zitt, Emanuel.
+Institution
+ Fritz, Josef. Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.
+ Brozek, Wolfgang. Agency for Preventive and Social Medicine, Bregenz, Austria.
+ Concin, Hans. Agency for Preventive and Social Medicine, Bregenz, Austria.
+ Nagel, Gabriele. Agency for Preventive and Social Medicine, Bregenz, Austria.
+ Nagel, Gabriele. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
+ Kerschbaum, Julia. Department of Internal Medicine IV (Nephrology and Hypertension), Innsbruck Medical University, Innsbruck, Austria.
+ Lhotta, Karl. Department of Internal Medicine III (Nephrology and Dialysis), Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
+ Lhotta, Karl. Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
+ Ulmer, Hanno. Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.
+ Ulmer, Hanno. Agency for Preventive and Social Medicine, Bregenz, Austria.
+ Zitt, Emanuel. Agency for Preventive and Social Medicine, Bregenz, Austria.
+ Zitt, Emanuel. Department of Internal Medicine III (Nephrology and Dialysis), Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
+ Zitt, Emanuel. Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
+MeSH Subject Headings
+ Adult
+ Austria/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Disease Progression
+ Female
+ Follow-Up Studies
+ *Forecasting
+ Humans
+ Incidence
+ *Kidney Failure, Chronic/bl [Blood]
+ Kidney Failure, Chronic/ep [Epidemiology]
+ Kidney Failure, Chronic/et [Etiology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Retrospective Studies
+ Risk Factors
+ *Triglycerides/bl [Blood]
+Abstract
+ Importance: It is unknown whether the triglyceride-glucose (TyG) index as a measure of insulin resistance is associated with the risk of developing end-stage kidney disease (ESKD). Because individuals who are overweight or obese often develop insulin resistance, mediation of the association between body mass index (BMI) and ESKD risk through the TyG index seems plausible but has not been investigated.
+
+ Objective: To evaluate whether the TyG index is associated with ESKD risk and, if so, to what extent the TyG index mediates the association between BMI and ESKD.
+
+ Design, Setting, and Participants: A total of 176420 individuals were recruited during routine health examinations to participate in the Austrian Vorarlberg Health Monitoring and Promotion Program (VHM&PP), a prospective, population-based cohort study with participant enrollment between January 1, 1988, and June 30, 2005, and a mean follow-up of 22.7 years. Data analysis was conducted from March 1, 2020, to September 30, 2020.
+
+ Exposures: Body mass index and the logarithmized product of fasting triglyceride and glucose concentrations (TyG index), as determined during the baseline health examination.
+
+ Main Outcomes and Measures: End-stage kidney disease, as indicated by initiation of kidney replacement therapy, either dialysis or kidney transplantation.
+
+ Results: Of the 176420 participants, 94 885 were women (53.8%); mean (SD) age was 42.5 (15.4) years. During a mean (SD) follow-up of 22.7 (6.9) years, 454 (0.3%) participants developed ESKD and 35234 (20.0%) died. In multivariable-adjusted Cox proportional hazards models, the TyG index was significantly associated with the risk of ESKD, both with (hazard ratio [HR] per 1-SD increase, 1.68; 95% CI, 1.56-1.82) and without (HR per 1-SD increase, 1.79; 95% CI, 1.66-1.93) the inclusion of BMI as a covariate. Mediation analysis using a newly proposed 2-stage regression method for survival data showed that a 5-point increase in BMI increased the risk of ESKD by 58% (HR [total association], 1.58; 95% CI, 1.43-1.75), and that 41.7% of the total association (95% CI, 31.6%-51.8%) was mediated through the TyG index (HR [indirect association], 1.21; 95% CI, 1.18-1.25).
+
+ Conclusions and Relevance: This study found that the TyG index appeared to be associated with ESKD risk and mediates nearly half of the total association between BMI and ESKD in the general population. Public health efforts aiming at the reduction of body weight might decrease the kidney sequelae of insulin resistance and the burden of ESKD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article. Multicenter Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1001%2fjamanetworkopen.2021.2612
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fritz&issn=2574-3805&title=JAMA+Network+Open&atitle=The+Triglyceride-Glucose+Index+and+Obesity-Related+Risk+of+End-Stage+Kidney+Disease+in+Austrian+Adults.&volume=4&issue=3&spage=e212612&epage=&date=2021&doi=10.1001%2Fjamanetworkopen.2021.2612&pmid=33787913&sid=OVID:medline
+
+<919>
+Unique Identifier
+ 33779121
+Title
+ Biomarkers in atrial fibrillation: a constant search for simplicity, practicality, and cost-effectiveness.
+Source
+ Kardiologia Polska. 79(3):243-245, 2021 03 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Boriani G; Valenti AC; Vitolo M
+Authors Full Name
+ Boriani, Giuseppe; Valenti, Anna C; Vitolo, Marco.
+Institution
+ Boriani, Giuseppe. Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, italy
+ Valenti, Anna C. Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, italy
+ Vitolo, Marco. Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, italy
+ Vitolo, Marco. Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, italy
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Anticoagulants
+ Atrial Fibrillation/di [Diagnosis]
+ *Atrial Fibrillation
+ Biomarkers
+ Cost-Benefit Analysis
+ Electric Countershock
+ Humans
+ Obesity
+Registry Number/Name of Substance
+ 0 (Anticoagulants). 0 (Biomarkers).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.33963%2fKP.15889
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Boriani&issn=0022-9032&title=Kardiologia+Polska&atitle=Biomarkers+in+atrial+fibrillation%3A+a+constant+search+for+simplicity%2C+practicality%2C+and+cost-effectiveness.&volume=79&issue=3&spage=243&epage=245&date=2021&doi=10.33963%2FKP.15889&pmid=33779121&sid=OVID:medline
+
+<920>
+Unique Identifier
+ 33771687
+Title
+ Associations of TNFA, IL17A, and RORC mRNA expression levels in peripheral blood leukocytes with obesity-related asthma in adolescents.
+Source
+ Clinical Immunology. 229:108715, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leija-Martinez JJ; Del-Rio-Navarro BE; Sanchez-Munoz F; Munoz-Hernandez O; Hong E; Giacoman-Martinez A; Romero-Nava R; Patricio-Roman KL; Hall-Mondragon MS; Espinosa-Velazquez D; Villafana S; Huang F
+Authors Full Name
+ Leija-Martinez, Jose J; Del-Rio-Navarro, Blanca E; Sanchez-Munoz, Fausto; Munoz-Hernandez, Onofre; Hong, Enrique; Giacoman-Martinez, Abraham; Romero-Nava, Rodrigo; Patricio-Roman, Karla L; Hall-Mondragon, Margareth S; Espinosa-Velazquez, Dario; Villafana, Santiago; Huang, Fengyang.
+Institution
+ Leija-Martinez, Jose J. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Hospital Infantil de Mexico Federico Gomez, Research Laboratory of Pharmacology, Mexico City, Mexico.
+ Del-Rio-Navarro, Blanca E. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Hospital Infantil de Mexico Federico Gomez, Department of Paediatric Allergy Clinical Immunology, Mexico City, Mexico.
+ Sanchez-Munoz, Fausto. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Departamento de Inmunologia, Instituto Nacional de Cardiologia "Ignacio Chavez", Mexico City, Mexico.
+ Munoz-Hernandez, Onofre. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico.
+ Hong, Enrique. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Department of Pharmacobiology, Centro de Investigacion de Estudio Avanzados del Instituto Politecnico Nacional, Mexico City, Calz. de Los Tenorios 235, Col. Granjas Coapa, 14330, Mexico.
+ Giacoman-Martinez, Abraham. Hospital Infantil de Mexico Federico Gomez, Research Laboratory of Pharmacology, Mexico City, Mexico.
+ Romero-Nava, Rodrigo. Hospital Infantil de Mexico Federico Gomez, Research Laboratory of Pharmacology, Mexico City, Mexico; Laboratorio de Senalizacion Intracelular, Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico.
+ Patricio-Roman, Karla L. Hospital Infantil de Mexico Federico Gomez, Research Laboratory of Pharmacology, Mexico City, Mexico; Laboratorio de Senalizacion Intracelular, Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico.
+ Hall-Mondragon, Margareth S. Hospital Infantil de Mexico Federico Gomez, Department of Paediatric Allergy Clinical Immunology, Mexico City, Mexico; Centro Medico Nacional "La Raza", Instituto Mexicano del Seguro Social. IMSS, Mexico.
+ Espinosa-Velazquez, Dario. Hospital Infantil de Mexico Federico Gomez, Department of Paediatric Allergy Clinical Immunology, Mexico City, Mexico.
+ Villafana, Santiago. Laboratorio de Senalizacion Intracelular, Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico.
+ Huang, Fengyang. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Hospital Infantil de Mexico Federico Gomez, Research Laboratory of Pharmacology, Mexico City, Mexico. Electronic address: huangfengyang@gmail.com.
+MeSH Subject Headings
+ Adolescent
+ *Asthma/co [Complications]
+ Asthma/ge [Genetics]
+ *Asthma/im [Immunology]
+ Biomarkers/bl [Blood]
+ Child
+ Cross-Sectional Studies
+ Female
+ Gene Expression
+ Humans
+ Interleukin-17/bl [Blood]
+ *Interleukin-17/ge [Genetics]
+ Leukocytes/im [Immunology]
+ Male
+ *Nuclear Receptor Subfamily 1, Group F, Member 3/ge [Genetics]
+ *Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ *Obesity/im [Immunology]
+ Phenotype
+ RNA, Messenger/bl [Blood]
+ *RNA, Messenger/ge [Genetics]
+ Th17 Cells/im [Immunology]
+ Tumor Necrosis Factor-alpha/bl [Blood]
+ *Tumor Necrosis Factor-alpha/ge [Genetics]
+Keyword Heading
+ Asthma
+ IL-17A
+ Non-allergic asthma
+ Obesity
+ RORC
+ Tumour necrosis factor-alpha
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with a unique non-T2 asthma phenotype, characterised by a Th17 immune response. Retinoid-related orphan receptor C (RORC) is the master transcription factor for Th17 polarisation. We investigated the association of TNFA, IL17A, and RORC mRNA expression levels with the non-T2 phenotype. We conducted a cross-sectional study in adolescents, subdivided as follows: healthy (HA), allergic asthma without obesity (AA), obesity without asthma (OB), and non-allergic asthma with obesity (NAO). TNFA, IL17A, and RORC mRNA expression in peripheral blood leukocytes were assessed by RT-PCR. NAO exhibited higher TNFA mRNA expression levels than HA or OB, as well as the highest IL17A and RORC mRNA expression levels among the four groups. The best biomarker for discriminating non-allergic asthma among obese adolescents was RORC mRNA expression levels (area under the curve: 0.95). RORC mRNA expression levels were associated with the non-T2 asthma phenotype, hinting at a therapeutic target in obesity-related asthma. Copyright © 2021 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IL17A protein, human). 0 (Interleukin-17). 0 (Nuclear Receptor Subfamily 1, Group F, Member 3). 0 (RNA, Messenger). 0 (RORC protein, human). 0 (TNF protein, human). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.clim.2021.108715
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leija-Martinez&issn=1521-6616&title=Clinical+Immunology&atitle=Associations+of+TNFA%2C+IL17A%2C+and+RORC+mRNA+expression+levels+in+peripheral+blood+leukocytes+with+obesity-related+asthma+in+adolescents.&volume=229&issue=&spage=108715&epage=&date=2021&doi=10.1016%2Fj.clim.2021.108715&pmid=33771687&sid=OVID:medline
+
+<921>
+Unique Identifier
+ 33771681
+Title
+ Obesity markers in patients with drug allergy and body fat as a predictor.
+Source
+ Annals of Allergy, Asthma, & Immunology. 127(1):100-108, 2021 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dias de Castro E; Pinhao S; Paredes S; Cernadas JR; Ribeiro L
+Authors Full Name
+ Dias de Castro, Eunice; Pinhao, Silvia; Paredes, Silvia; Cernadas, Josefina R; Ribeiro, Laura.
+Institution
+ Dias de Castro, Eunice. Allergy and Clinical Immunology Department, Centro Hospitalar Universitario de S. Joao EPE, Porto, Portugal; MedInUP-Center for Drug Discover and Innovative Medicines, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address: eunicediascastro@gmail.com.
+ Pinhao, Silvia. Nutrition Department, Centro Hospitalar Universitario de S. Joao EPE, Porto, Portugal; Faculty of Food and Nutrition Sciences, University of Porto, Porto, Portugal.
+ Paredes, Silvia. Public Health and Forensic Sciences and Medical Education Department, Faculty of Medicine, University of Porto, Porto, Portugal.
+ Cernadas, Josefina R. Allergy and Clinical Immunology Department, Centro Hospitalar Universitario de S. Joao EPE, Porto, Portugal.
+ Ribeiro, Laura. Public Health and Forensic Sciences and Medical Education Department, Faculty of Medicine, University of Porto, Porto, Portugal; Biomedicine Department, Faculty of Medicine, University of Porto, Porto, Portugal; I3S-Instituto de Investigacao e Inovacao em Saude, University of Porto, Porto, Portugal.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adipose Tissue
+ Adiposity
+ Adult
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Drug Hypersensitivity/bl [Blood]
+ Female
+ Humans
+ Leptin/bl [Blood]
+ Logistic Models
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Overweight/bl [Blood]
+ Prospective Studies
+ Waist-Hip Ratio
+Abstract
+ BACKGROUND: Obesity is a chronic low-grade inflammation state associated with several diseases.
+
+ OBJECTIVE: To investigate a potential link between drug allergy and obesity, exploring whether the association depends on the type (immediate vs nonimmediate) or the severity of the reaction.
+
+ METHODS: Anthropometric measurements, bioimpedance, and biochemical analysis, including serum adipokines, were performed in 90 consecutive adult patients studied for suspected drug allergy. Logistic regression models were developed to identify predictors of drug allergy.
+
+ RESULTS: A total of 84 patients completed the diagnostic workup (78.6% women; mean age 39.58 +/- 13.3 years). Drug allergy was confirmed in 39 patients and excluded in 45 (controls). Regarding body mass index, 42.2% had normal weight and 55.3% were overweight/obese. A total of 58% of women and 41% of men fulfilled the criteria for central obesity. Patients with drug allergy exhibited considerably higher body mass index, waist and hip circumferences, waist-hip ratio, fat mass, body fat percentage (BFP), trunk fat mass, leptin levels, and leptin-adiponectin ratio than controls. Similar results were obtained in the subgroup with immediate reactions, compared with the nonimmediate or unknown reactions. The higher the BFP and the number of reactions, the greater the odds of drug allergy (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.01-1.14 and OR, 2.82; 95% CI, 1.31-6.10, respectively). An immediate reaction was also a predictor of drug allergy (OR, 3.81; 95% CI, 1.30-11.14, P = .02), compared with nonimmediate or unknown reactions. In patients with drug allergy, BFP was a predictor of having an immediate reaction (OR, 1.12; 95% CI, 1.02-1.24, P = .02).
+
+ CONCLUSION: Our study illustrates, for the first time, evidence of a link between obesity and drug allergy, particularly immediate reactions. The BFP emerged as a potential predictor of drug allergy. Copyright © 2021. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.anai.2021.03.014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dias+de+Castro&issn=1081-1206&title=Annals+of+Allergy%2C+Asthma%2C+%26+Immunology&atitle=Obesity+markers+in+patients+with+drug+allergy+and+body+fat+as+a+predictor.&volume=127&issue=1&spage=100&epage=108&date=2021&doi=10.1016%2Fj.anai.2021.03.014&pmid=33771681&sid=OVID:medline
+
+<922>
+Unique Identifier
+ 33766576
+Title
+ Hippocampal neural cell loss in high-fat diet-induced obese rats-exploring the protein networks, ultrastructure, biochemical and bioinformatical markers.
+Source
+ Journal of Chemical Neuroanatomy. 114:101947, 2021 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alkan I; Altunkaynak BZ; Gultekin GI; Baycu C
+Authors Full Name
+ Alkan, Isinsu; Altunkaynak, Berrin Zuhal; Gultekin, Guldal Inal; Baycu, Cengiz.
+Institution
+ Alkan, Isinsu. Dept of Basic Medical Sciences, Dentistry Faculty, Nevsehir Haci Bektas Veli University, Nevsehir Turkey.
+ Altunkaynak, Berrin Zuhal. Depts of Histology and Embryology and Physiology Departments, Medical Faculty, Istanbul Okan University, Istanbul, Turkey. Electronic address: zuhal.altunkaynak@okan.edu.tr.
+ Gultekin, Guldal Inal. Physiology Department, Medical Faculty, Istanbul Okan University, Istanbul, Turkey.
+ Baycu, Cengiz. Histology Department, Medical Faculty, Istanbul Okan University, Istanbul, Turkey.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Brain-Derived Neurotrophic Factor/me [Metabolism]
+ Computational Biology
+ *Diet, High-Fat/ae [Adverse Effects]
+ Female
+ *Hippocampus/pa [Pathology]
+ Hippocampus/pp [Physiopathology]
+ *Obesity/pp [Physiopathology]
+ Oxidative Stress/ph [Physiology]
+ Proto-Oncogene Proteins c-fos/me [Metabolism]
+ *Pyramidal Cells/pa [Pathology]
+ Rats
+ Rats, Sprague-Dawley
+Keyword Heading
+ BDNF
+ C-Fos
+ High fat diet
+ Hippocampus
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Obesity, which has become one of the main health problems, results from irregular and unhealthy nutrition. In particular, an increase in the intake of high-fat foods leads to obesity and associated disorders. It is noteworthy to specify that obese individuals have memory problems. This study aims to examine the effects of high-fat diet on hippocampus, with stereological, histopathological methods and STRING bioinformatic tool.
+
+ METHODS: Female Adult Sprague Dawley rats (n = 20) were equally divided into control (CONT) and high-fat diet (HFD) groups. The control group was given standard rat pellet feed, while the high-fat diet group was fed with a 40 % fat content for 2 months. Following the feeding program, rats were sacrificed. The collected blood samples were analyzed biochemically to determine the level of oxidative stress while performing a stereological and histopathological examination of the brain tissues. Functional protein-protein networks for BDNF, C-Fos, CAT, LPO, SOD and MPO by gene ontology (GO) enrichment analysis were evaluated.
+
+ FINDINGS: The number of neurons decreased in the HFD group compared to the CONT group. Damage to the histological structure of the hippocampus region; such as degenerate neurons, damaged mitochondria and extended cisterns of the endoplasmic reticulum was observed. Although C-Fos level and oxidative stress parameters increased in HFD group, BDNF level decreased. While BDNF and C-Fos were observed in pathways related to neuron death, oxidative stress and memory, BDNF was pronounced in the mitochondria, and C-Fos in the endoplasmic reticulum.
+
+ DISCUSSION: This study shows that changes in both BDNF and C-Fos levels in obesity due to high-fat diet increase oxidative stress and cause neuron damage in the hippocampus. Copyright © 2021 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Bdnf protein, rat). 0 (Biomarkers). 0 (Brain-Derived Neurotrophic Factor). 0 (Proto-Oncogene Proteins c-fos).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.jchemneu.2021.101947
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alkan&issn=0891-0618&title=Journal+of+Chemical+Neuroanatomy&atitle=Hippocampal+neural+cell+loss+in+high-fat+diet-induced+obese+rats-exploring+the+protein+networks%2C+ultrastructure%2C+biochemical+and+bioinformatical+markers.&volume=114&issue=&spage=101947&epage=&date=2021&doi=10.1016%2Fj.jchemneu.2021.101947&pmid=33766576&sid=OVID:medline
+
+<923>
+Unique Identifier
+ 33765028
+Title
+ Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.
+Source
+ PLoS ONE [Electronic Resource]. 16(3):e0249057, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aztatzi-Aguilar OG; Sierra-Vargas MP; Ortega-Romero M; Jimenez-Corona AE
+Author NameID
+ Sierra-Vargas, Martha Patricia; ORCID: https://orcid.org/0000-0002-1894-745X
+Authors Full Name
+ Aztatzi-Aguilar, Octavio Gamaliel; Sierra-Vargas, Martha Patricia; Ortega-Romero, Manolo; Jimenez-Corona, Azucena Eunice.
+Institution
+ Aztatzi-Aguilar, Octavio Gamaliel. Departamento de Investigacion en Toxicologia y Medicina Ambiental, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, CDMX, Mexico.
+ Aztatzi-Aguilar, Octavio Gamaliel. Catedras CONACyT, CDMX, Mexico.
+ Sierra-Vargas, Martha Patricia. Departamento de Investigacion en Toxicologia y Medicina Ambiental, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, CDMX, Mexico.
+ Sierra-Vargas, Martha Patricia. Facultad Mexicana de Medicina, Universidad La Salle, CDMX, Mexico.
+ Ortega-Romero, Manolo. Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional, CDMX, Mexico.
+ Jimenez-Corona, Azucena Eunice. Escuela Superior de Huejutla, Universidad Autonoma del Estado de Hidalgo, Huejutla, Hidalgo, Mexico.
+MeSH Subject Headings
+ Adolescent
+ Aryldialkylphosphatase/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Catalase/me [Metabolism]
+ Female
+ Humans
+ Lipid Peroxidation
+ Male
+ Metabolic Syndrome/di [Diagnosis]
+ *Nutritional Status
+ Obesity/di [Diagnosis]
+ *Osteopontin/bl [Blood]
+ *Oxidative Stress/ge [Genetics]
+ Pilot Projects
+ Triglycerides/bl [Blood]
+ Uric Acid/bl [Blood]
+Abstract
+ Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with those diseases. The present study relates serum OPN levels with nutritional condition and oxidative stress in a group of adolescents. Anthropometric measurements were performed, and fasting blood samples were analyzed to determine OPN concentrations, blood chemistry parameters (glucose, triglycerides, total cholesterol, urea, uric acid, and creatinine) and oxidative stress biomarkers (Paraoxonase-1, Glutathione S-Transferase, Catalase, NAD(P)H Quinone Oxidoreductase, free carbonyl groups and malondialdehyde). Adolescents were categorized according to body mass index (BMI) and metabolic syndrome (MetS) criteria. We found increased OPN serum concentrations in overweight and obese adolescents, as well as in adolescents with MetS. Rises in OPN correlated with arm circumference and biomarkers of lipid peroxidation; with regard to serum glucose there was a trend to positive correlation. Our results suggest that serum OPN is associated to nutritional status and could be considered as an early biomarker of low-grade inflammation and probably the early biomineralization of soft tissues in adolescence.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides). 106441-73-0 (Osteopontin). 268B43MJ25 (Uric Acid). EC 1-11-1-6 (Catalase). EC 3-1-8-1 (Aryldialkylphosphatase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1371%2fjournal.pone.0249057
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aztatzi-Aguilar&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Osteopontin%27s+relationship+with+malnutrition+and+oxidative+stress+in+adolescents.+A+pilot+study.&volume=16&issue=3&spage=e0249057&epage=&date=2021&doi=10.1371%2Fjournal.pone.0249057&pmid=33765028&sid=OVID:medline
+
+<924>
+Unique Identifier
+ 33760825
+Title
+ Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients.
+Source
+ PLoS ONE [Electronic Resource]. 16(3):e0245424, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Frasca D; Reidy L; Cray C; Diaz A; Romero M; Kahl K; Blomberg BB
+Author NameID
+ Frasca, Daniela; ORCID: https://orcid.org/0000-0002-9816-6679
+Authors Full Name
+ Frasca, Daniela; Reidy, Lisa; Cray, Carolyn; Diaz, Alain; Romero, Maria; Kahl, Kristin; Blomberg, Bonnie B.
+Institution
+ Frasca, Daniela. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Frasca, Daniela. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Reidy, Lisa. Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Cray, Carolyn. Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Diaz, Alain. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Romero, Maria. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Kahl, Kristin. Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Blomberg, Bonnie B. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Blomberg, Bonnie B. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+Comments
+ Update of (UOF)
+MeSH Subject Headings
+ Adult
+ Aged
+ Antibodies/bl [Blood]
+ Antibodies/im [Immunology]
+ Antibodies, Viral/bl [Blood]
+ *Antibodies, Viral/im [Immunology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ COVID-19/bl [Blood]
+ COVID-19/ep [Epidemiology]
+ *COVID-19/im [Immunology]
+ Coronavirus Infections/vi [Virology]
+ Female
+ Humans
+ Immunity, Humoral/im [Immunology]
+ Immunoglobulin A/bl [Blood]
+ Immunoglobulin A/im [Immunology]
+ Immunoglobulin G/bl [Blood]
+ Immunoglobulin G/im [Immunology]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Obesity/vi [Virology]
+ SARS-CoV-2/im [Immunology]
+ SARS-CoV-2/py [Pathogenicity]
+Abstract
+ SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions.
+Registry Number/Name of Substance
+ 0 (Antibodies). 0 (Antibodies, Viral). 0 (Biomarkers). 0 (Immunoglobulin A). 0 (Immunoglobulin G).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1371%2fjournal.pone.0245424
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Frasca&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Influence+of+obesity+on+serum+levels+of+SARS-CoV-2-specific+antibodies+in+COVID-19+patients.&volume=16&issue=3&spage=e0245424&epage=&date=2021&doi=10.1371%2Fjournal.pone.0245424&pmid=33760825&sid=OVID:medline
+
+<925>
+Unique Identifier
+ 33754794
+Title
+ Obesity and Serial NT-proBNP Levels in Guided Medical Therapy for Heart Failure With Reduced Ejection Fraction: Insights From the GUIDE-IT Trial.
+Source
+ Journal of the American Heart Association. 10(7):e018689, 2021 04 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Parcha V; Patel N; Kalra R; Suri SS; Arora G; Wang TJ; Arora P
+Authors Full Name
+ Parcha, Vibhu; Patel, Nirav; Kalra, Rajat; Suri, Sarabjeet S; Arora, Garima; Wang, Thomas J; Arora, Pankaj.
+Institution
+ Parcha, Vibhu. Division of Cardiovascular Disease University of Alabama at Birmingham AL.
+ Patel, Nirav. Department of Medicine University of Alabama at Birmingham AL.
+ Kalra, Rajat. Cardiovascular Division University of Minnesota Minneapolis MN.
+ Suri, Sarabjeet S. Division of Cardiovascular Disease University of Alabama at Birmingham AL.
+ Arora, Garima. Division of Cardiovascular Disease University of Alabama at Birmingham AL.
+ Wang, Thomas J. Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.
+ Arora, Pankaj. Division of Cardiovascular Disease University of Alabama at Birmingham AL.
+ Arora, Pankaj. Section of Cardiology Birmingham Veterans Affairs Medical Center Birmingham AL.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Diuretics/ad [Administration & Dosage]
+ Dose-Response Relationship, Drug
+ Female
+ Heart Failure/bl [Blood]
+ Heart Failure/co [Complications]
+ *Heart Failure/dt [Drug Therapy]
+ Hospitalization/td [Trends]
+ Humans
+ Infusions, Intravenous
+ Male
+ Middle Aged
+ *Natriuretic Peptide, Brain/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Peptide Fragments/bl [Blood]
+ Prognosis
+ Protein Precursors
+ *Stroke Volume/ph [Physiology]
+Keyword Heading
+ cardiovascular outcomes
+ heart failure
+ mortality
+ natriuretic peptides
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Obese patients have lower NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. The prognostic implications of achieving NT-proBNP levels <=1000 pg/mL in obese patients with heart failure (HF) receiving biomarker-guided therapy are not completely known. We evaluated the prognostic implications of obesity and having NT-proBNP levels (<=1000 pg/mL) in the GUIDE-IT (Guiding Evidence-Based Therapy Using Biomarker-Intensified Treatment in HF) trial participants. Methods and Results The risk of adverse cardiovascular events (HF hospitalization or cardiovascular mortality) was assessed using multivariable-adjusted Cox proportional hazard models based on having NT-proBNP <=1000 pg/mL (taken as a time-varying covariate), stratified by obesity status. The study outcome was also assessed on the basis of the body mass index at baseline. The predictive ability of NT-proBNP for adverse cardiovascular events was assessed using the likelihood ratio test. Compared with nonobese patients, obese patients were mostly younger, Black race, and more likely to be women. NT-proBNP levels were 59.0% (95% CI, 39.5%-83.5%) lower among obese individuals. The risk of adverse cardiovascular events was lower in obese (hazard ratio [HR], 0.48; 95% CI, 0.29-0.59) and nonobese (HR, 0.32; 95% CI, 0.19-0.57) patients with HF who had NT-proBNP levels <=1000 pg/mL, compared with those who did not. There was no interaction between obesity and having NT-proBNP <=1000 pg/mL on the study outcome (P>0.10). Obese patients had a greater risk of developing adverse cardiovascular events (HR, 1.39; 95% CI, 1.01-1.90) compared with nonobese patients. NT-proBNP was the strongest predictor of adverse cardiovascular event risk in both obese and nonobese patients. Conclusions On-treatment NT-proBNP level <=1000 pg/mL has favorable prognostic implications, irrespective of obesity status. NT-proBNP levels were the strongest predictor of cardiovascular events in both obese and nonobese individuals in this trial. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT01685840.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Diuretics). 0 (Peptide Fragments). 0 (Protein Precursors). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1161%2fJAHA.120.018689
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Parcha&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Obesity+and+Serial+NT-proBNP+Levels+in+Guided+Medical+Therapy+for+Heart+Failure+With+Reduced+Ejection+Fraction%3A+Insights+From+the+GUIDE-IT+Trial.&volume=10&issue=7&spage=e018689&epage=&date=2021&doi=10.1161%2FJAHA.120.018689&pmid=33754794&sid=OVID:medline
+
+<926>
+Unique Identifier
+ 33754165
+Title
+ Fecal microbiota signatures of insulin resistance, inflammation, and metabolic syndrome in youth with obesity: a pilot study.
+Source
+ Acta Diabetologica. 58(8):1009-1022, 2021 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Del Chierico F; Manco M; Gardini S; Guarrasi V; Russo A; Bianchi M; Tortosa V; Quagliariello A; Shashaj B; Fintini D; Putignani L
+Author NameID
+ Manco, Melania; ORCID: http://orcid.org/0000-0002-6581-975X
+Authors Full Name
+ Del Chierico, Federica; Manco, Melania; Gardini, Simone; Guarrasi, Valerio; Russo, Alessandra; Bianchi, Marzia; Tortosa, Valentina; Quagliariello, Andrea; Shashaj, Blegina; Fintini, Danilo; Putignani, Lorenza.
+Institution
+ Del Chierico, Federica. Unit of Human Microbiome, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
+ Manco, Melania. Research Area for Multifactorial Diseases and Complex Phenotypes, Obesity and Diabetes, Bambino Gesu Children's Hospital, IRCCS, Via Ferdinando Baldelli 38, 00146, Rome, Italy. melania.manco@opbg.net.
+ Gardini, Simone. GenomeUp SRL, Rome, Italy.
+ Guarrasi, Valerio. GenomeUp SRL, Rome, Italy.
+ Guarrasi, Valerio. Department of Computer, Control, and Management Engineering Antonio Ruberti, Sapienza University, Rome, Italy.
+ Russo, Alessandra. Unit of Parasitology, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
+ Bianchi, Marzia. Research Area for Multifactorial Diseases and Complex Phenotypes, Obesity and Diabetes, Bambino Gesu Children's Hospital, IRCCS, Via Ferdinando Baldelli 38, 00146, Rome, Italy.
+ Tortosa, Valentina. Unit of Human Microbiome, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
+ Quagliariello, Andrea. Unit of Human Microbiome, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
+ Shashaj, Blegina. Research Area for Multifactorial Diseases and Complex Phenotypes, Obesity and Diabetes, Bambino Gesu Children's Hospital, IRCCS, Via Ferdinando Baldelli 38, 00146, Rome, Italy.
+ Fintini, Danilo. Endocrinology Unit, Bambino Gesu Children's Hospital, IRCCS, Palidoro, Rome, Italy.
+ Putignani, Lorenza. Unit of Parasitology and Unit of Human Microbiome, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
+MeSH Subject Headings
+ Adolescent
+ Bacteria/cl [Classification]
+ Bacteria/ge [Genetics]
+ Biomarkers/bl [Blood]
+ Child
+ *Feces/mi [Microbiology]
+ Female
+ Glucose Intolerance/mi [Microbiology]
+ Humans
+ Hypertension/mi [Microbiology]
+ *Inflammation/mi [Microbiology]
+ *Insulin Resistance/ph [Physiology]
+ Male
+ *Metabolic Syndrome/mi [Microbiology]
+ Metagenomics
+ *Microbiota/ph [Physiology]
+ Obesity/co [Complications]
+ *Obesity
+ Pilot Projects
+ RNA, Ribosomal, 16S/an [Analysis]
+ Risk Factors
+ Triglycerides/bl [Blood]
+Keyword Heading
+ Cardiovascular diseases
+ Gut microbiota
+ Insulin resistance
+ Low-grade inflammation
+ Metabolic syndrome
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: To identify fecal microbiota profiles associated with metabolic abnormalities belonging to the metabolic syndrome (MS), high count of white blood cells (WBCs) and insulin resistance (IR).
+
+ METHODS: Sixty-eight young patients with obesity were stratified for percentile distribution of MS abnormalities. A MS risk score was defined as low, medium, and high MS risk. High WBCs were defined as a count >= 7.0 103/microL; severe obesity as body mass index Z-score >= 2 standard deviations; IR as homeostatic assessment model algorithm of IR (HOMA) >= 3.7. Stool samples were analyzed by 16S rRNA-based metagenomics.
+
+ RESULTS: We found reduced bacterial richness of fecal microbiota in patients with IR and high diastolic blood pressure (BP). Distinct microbial markers were associated to high BP (Clostridium and Clostridiaceae), low high-density lipoprotein cholesterol (Lachnospiraceae, Gemellaceae, Turicibacter), and high MS risk (Coriobacteriaceae), WBCs (Bacteroides caccae, Gemellaceae), severe obesity (Lachnospiraceae), and impaired glucose tolerance (Bacteroides ovatus and Enterobacteriaceae). Conversely, taxa such as Faecalibacterium prausnitzii, Parabacterodes, Bacteroides caccae, Oscillospira, Parabacterodes distasonis, Coprococcus, and Haemophilus parainfluenzae were associated to low MS risk score, triglycerides, fasting glucose and HOMA-IR, respectively. Supervised multilevel analysis grouped clearly "variable" patients based on the MS risk.
+
+ CONCLUSIONS: This was a proof-of-concept study opening the way at the identification of fecal microbiota signatures, precisely associated with cardiometabolic risk factors in young patients with obesity. These evidences led us to infer, while some gut bacteria have a detrimental role in exacerbating metabolic risk factors some others are beneficial ameliorating cardiovascular host health. Copyright © 2021. Springer-Verlag Italia S.r.l., part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Ribosomal, 16S). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs00592-020-01669-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Del+Chierico&issn=0940-5429&title=Acta+Diabetologica&atitle=Fecal+microbiota+signatures+of+insulin+resistance%2C+inflammation%2C+and+metabolic+syndrome+in+youth+with+obesity%3A+a+pilot+study.&volume=58&issue=8&spage=1009&epage=1022&date=2021&doi=10.1007%2Fs00592-020-01669-4&pmid=33754165&sid=OVID:medline
+
+<927>
+Unique Identifier
+ 33752129
+Title
+ Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development.
+Source
+ EBioMedicine. 66:103287, 2021 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lewandowski CT; Khan MW; BenAissa M; Dubrovskyi O; Ackerman-Berrier M; LaDu MJ; Layden BT; Thatcher GRJ
+Authors Full Name
+ Lewandowski, Cutler T; Khan, Md Wasim; BenAissa, Manel; Dubrovskyi, Oleksii; Ackerman-Berrier, Martha; LaDu, Mary Jo; Layden, Brian T; Thatcher, Gregory R J.
+Institution
+ Lewandowski, Cutler T. Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.
+ Khan, Md Wasim. Department of Medicine, University of Illinois at Chicago, 835 S. Wolcott St., Chicago, IL 60612, USA.
+ BenAissa, Manel. Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.
+ Dubrovskyi, Oleksii. Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.
+ Ackerman-Berrier, Martha. Department of Pharmacology and Toxicology, University of Arizona, 1295N. Martin, Tucson, AZ 85721, USA.
+ LaDu, Mary Jo. Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
+ Layden, Brian T. Department of Medicine, University of Illinois at Chicago, 835 S. Wolcott St., Chicago, IL 60612, USA. Electronic address: blayde1@uic.edu.
+ Thatcher, Gregory R J. Department of Pharmacology and Toxicology, University of Arizona, 1295N. Martin, Tucson, AZ 85721, USA. Electronic address: grjthatcher@arizona.edu.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ *ATP Binding Cassette Transporter 1/ag [Agonists]
+ Adiposity/de [Drug Effects]
+ Animals
+ Biomarkers
+ Cytokines/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ Disease Susceptibility
+ Drug Development
+ Glucose Intolerance
+ Inflammation Mediators/me [Metabolism]
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Lipogenesis
+ Liver X Receptors/ag [Agonists]
+ Male
+ *Metabolome
+ Metabolomics/mt [Methods]
+ *Metabolomics
+ Mice
+ Molecular Targeted Therapy
+ Obesity/dt [Drug Therapy]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Peroxisome Proliferator-Activated Receptors/ai [Antagonists & Inhibitors]
+ RNA, Small Interfering/ge [Genetics]
+ Retinoid X Receptors/ai [Antagonists & Inhibitors]
+Keyword Heading
+ ABCA1
+ Anti-inflammatory
+ Drug discovery
+ High-fat diet
+ Metabolomics
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Therapeutic agents with novel mechanisms of action are needed to combat the growing epidemic of type 2 diabetes (T2D) and related metabolic syndromes. Liver X receptor (LXR) agonists possess preclinical efficacy yet produce side effects due to excessive lipogenesis. Anticipating that many beneficial and detrimental effects of LXR agonists are mediated by ABCA1 and SREPB1c expression, respectively, we hypothesized that a phenotypic optimization strategy prioritizing selective ABCA1 induction would identify an efficacious lead compound with an improved side effect profile over existing LXRbeta agonists.
+
+ METHODS: We synthesized and characterized a novel small molecule for selective induction of ABCA1 vs. SREBP1c in vitro. This compound was evaluated in both wild-type mice and a high-fat diet (HFD) mouse model of obesity-driven diabetes through functional, biochemical, and metabolomic analysis.
+
+ FINDINGS: Six weeks of oral administration of our lead compound attenuated weight gain, glucose intolerance, insulin signaling deficits, and adiposity. Global metabolomics revealed suppression of gluconeogenesis, free fatty acids, and pro-inflammatory metabolites. Target identification linked these beneficial effects to selective LXRbeta agonism and PPAR/RXR antagonism.
+
+ INTERPRETATION: Our observations in the HFD model, combined with the absence of lipogenesis and neutropenia in WT mice, support this novel approach to therapeutic development for T2D and related conditions. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ABCA1 protein, mouse). 0 (ATP Binding Cassette Transporter 1). 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators). 0 (Lipids). 0 (Liver X Receptors). 0 (Peroxisome Proliferator-Activated Receptors). 0 (RNA, Small Interfering). 0 (Retinoid X Receptors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.ebiom.2021.103287
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lewandowski&issn=2352-3964&title=EBioMedicine&atitle=Metabolomic+analysis+of+a+selective+ABCA1+inducer+in+obesogenic+challenge+provides+a+rationale+for+therapeutic+development.&volume=66&issue=&spage=103287&epage=&date=2021&doi=10.1016%2Fj.ebiom.2021.103287&pmid=33752129&sid=OVID:medline
+
+<928>
+Unique Identifier
+ 33749466
+Title
+ The paradox of the role of resistin in early-onset obesity hypertension: A comparative study among four Chinese adult subgroups.
+Source
+ Clinical & Experimental Hypertension (New York). 43(5):385-391, 2021 Jul 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu O; Leng JH; Yang FF; Zhang H; Zhang XY; Li JJ; Lu X
+Authors Full Name
+ Wu, Ou; Leng, Jian Hang; Yang, Fen Fang; Zhang, Hu; Zhang, Xing Yu; Li, Jia Jia; Lu, Xi.
+Institution
+ Wu, Ou. Shulan International Medical College, Zhejiang Shuren University, Zhejiang, P.R. China.
+ Wu, Ou. Hangzhou Center for Disease Control and Prevention, Zhejiang, P.R. China.
+ Leng, Jian Hang. Department of Central Laboratory/Medical Examination Center of Hangzhou, The Frist People's Hospital of Hangzhou, Zhejiang, P.R. China.
+ Yang, Fen Fang. Department of Central Laboratory/Medical Examination Center of Hangzhou, The Frist People's Hospital of Hangzhou, Zhejiang, P.R. China.
+ Zhang, Hu. Department of Thoracic Surgery, Sir Run Run Shaw Hospital Affiliated with Medical College of Zhejiang University, Zhejiang, P.R. China.
+ Zhang, Xing Yu. Applied Biostatistics Laboratory, University of Michigan School of Nursing, Ann Arbor, USA.
+ Li, Jia Jia. Department of Central Laboratory, The First Affiliated Hospital of Anhui Medical University, Anhui, P.R. China.
+ Lu, Xi. Hangzhou Vocational and Technical College, Zhejiang, P.R. China.
+MeSH Subject Headings
+ Adult
+ *Asian People
+ Biomarkers/bl [Blood]
+ Blood Pressure
+ Body Mass Index
+ China
+ Female
+ Humans
+ *Hypertension/bl [Blood]
+ Hypertension/co [Complications]
+ Hypertension/pp [Physiopathology]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Resistin/bl [Blood]
+ Waist Circumference
+Keyword Heading
+ Resistin
+ blood pressure
+ body Mass Index
+ hypertension
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: To explore the role of resistin in the onset and development of obesity-related hypertension. Methods: Resistin serum levels were tested by ELISA in 153 adult subjects among four characteristic Chinese adult physical examination groups. Waist circumference (WC), body mass index (BMI), systolic blood pressure (SB), diastolic blood pressure (DB), and other clinical laboratory data were collected. Following, correlations between research index and differences between groups were analyzed using SPSS. Results: Serum resistin levels statistically significantly negatively correlated with SB, DB and BMI, but statistically significantly positively correlated with serum creatinine (SCR) and serum albumin (ALB), even after adjustment for age and/or gender. The serum level of resistin in the normal healthy subject group (NH) was higher than in other groups. Conclusions: Resistin's role in the onset of obesity-related hypertension may be more important than what has been previously assumed. More pathway substances in the early onset of obesity-related hypertension should be tested. Abbreviations: WC, waist circumference; GGT, Gamma-glutamyltransferase; ALB, Albumin; ALT, Alanine aminotransferase; LDL, Low density lipoprotein cholesterol; TG, Triglyceride; HDLC, High density lipoprotein cholesterol; FA Fructosamine; SCR, serum creatinine; IB, Indirect bilirubin; ALP, Alkaline phosphatase; CB, Conjugated bilirubin; UREA, Urea; Ua, Uric acid; FBG, fasting blood glucose; TC, Total cholesterol; TB, Total bilirubin; TP, Total protein; TC/HDLC, TC/HDLC ratio; SB, systolic blood pressure; DB, diastolic blood pressure.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Resistin).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1080%2f10641963.2021.1883049
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=1064-1963&title=Clinical+%26+Experimental+Hypertension+%28New+York%29&atitle=The+paradox+of+the+role+of+resistin+in+early-onset+obesity+hypertension%3A+A+comparative+study+among+four+Chinese+adult+subgroups.&volume=43&issue=5&spage=385&epage=391&date=2021&doi=10.1080%2F10641963.2021.1883049&pmid=33749466&sid=OVID:medline
+
+<929>
+Unique Identifier
+ 33746906
+Title
+ Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes.
+Source
+ Frontiers in Endocrinology. 12:642432, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bayliss J; Ooi GJ; De Nardo W; Shah YJH; Montgomery MK; McLean C; Kemp W; Roberts SK; Brown WA; Burton PR; Watt MJ
+Authors Full Name
+ Bayliss, Jacqueline; Ooi, Geraldine J; De Nardo, William; Shah, Yazmin Johari Halim; Montgomery, Magdalene K; McLean, Catriona; Kemp, William; Roberts, Stuart K; Brown, Wendy A; Burton, Paul R; Watt, Matthew J.
+Institution
+ Bayliss, Jacqueline. Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC, Australia.
+ Ooi, Geraldine J. Department of Surgery, Centre for Obesity Research and Education, Monash University, Melbourne, VIC, Australia.
+ De Nardo, William. Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC, Australia.
+ Shah, Yazmin Johari Halim. Department of Surgery, Centre for Obesity Research and Education, Monash University, Melbourne, VIC, Australia.
+ Montgomery, Magdalene K. Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC, Australia.
+ McLean, Catriona. Department of Anatomical Pathology, Alfred Health, Melbourne, VIC, Australia.
+ Kemp, William. Department of Gastroenterology, The Alfred Hospital and Monash University, Melbourne, VIC, Australia.
+ Roberts, Stuart K. Department of Gastroenterology, The Alfred Hospital and Monash University, Melbourne, VIC, Australia.
+ Brown, Wendy A. Department of Surgery, Centre for Obesity Research and Education, Monash University, Melbourne, VIC, Australia.
+ Burton, Paul R. Department of Surgery, Centre for Obesity Research and Education, Monash University, Melbourne, VIC, Australia.
+ Watt, Matthew J. Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC, Australia.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Biopsy
+ Body Mass Index
+ Cross-Sectional Studies
+ *Cytokines/me [Metabolism]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ *Ectodysplasins/bl [Blood]
+ *Ectodysplasins/me [Metabolism]
+ Female
+ Humans
+ Inflammation
+ *Insulin Resistance
+ Liver/me [Metabolism]
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ RNA, Messenger/me [Metabolism]
+ ROC Curve
+ Sensitivity and Specificity
+Keyword Heading
+ ectodysplasin A
+ hepatokine
+ insulin resistance
+ non-alcoholic fatty liver disease
+ type 2 diabetes (T2DM)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of obese mice and causes skeletal muscle insulin resistance. We assessed if liver and plasma EDA is associated with worsening non-alcoholic fatty liver disease (NAFLD) in obese patients and evaluated plasma EDA as a biomarker for NAFLD. Using a cross-sectional study in a public hospital, patients with a body mass index >30 kg/m2 (n=152) underwent liver biopsy for histopathology assessment and fasting liver EDA mRNA. Fasting plasma EDA levels were also assessed. Non-alcoholic fatty liver (NAFL) was defined as >5% hepatic steatosis and nonalcoholic steatohepatitis (NASH) as NAFLD activity score >=3. Patients were divided into three groups: No NAFLD (n=45); NAFL (n=65); and NASH (n=42). Liver EDA mRNA was increased in patients with NASH compared with No NAFLD (P=0.05), but not NAFL. Plasma EDA levels were increased in NAFL and NASH compared with No NAFLD (P=0.03). Plasma EDA was related to worsening steatosis (P=0.02) and fibrosis (P=0.04), but not inflammation or hepatocellular ballooning. ROC analysis indicates that plasma EDA is not a reliable biomarker for NAFL or NASH. Plasma EDA was not increased in patients with type 2 diabetes and did not correlate with insulin resistance. Together, we show that plasma EDA is increased in NAFL and NASH, is related to worsening steatosis and fibrosis but is not a reliable biomarker for NASH. Circulating EDA is not associated with insulin resistance in human obesity.
+
+ Clinical Trial Registration: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12615000875505, identifier ACTRN12615000875505. Copyright © 2021 Bayliss, Ooi, De Nardo, Shah, Montgomery, McLean, Kemp, Roberts, Brown, Burton and Watt.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Ectodysplasins). 0 (RNA, Messenger).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3389%2ffendo.2021.642432
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bayliss&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Ectodysplasin+A+Is+Increased+in+Non-Alcoholic+Fatty+Liver+Disease%2C+But+Is+Not+Associated+With+Type+2+Diabetes.&volume=12&issue=&spage=642432&epage=&date=2021&doi=10.3389%2Ffendo.2021.642432&pmid=33746906&sid=OVID:medline
+
+<930>
+Unique Identifier
+ 33743282
+Title
+ Impact of gut microbiota on plasma oxylipins profile under healthy and obesogenic conditions.
+Source
+ Clinical Nutrition. 40(4):1475-1486, 2021 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Avila-Roman J; Arreaza-Gil V; Cortes-Espinar AJ; Soliz-Rueda JR; Mulero M; Muguerza B; Arola-Arnal A; Arola L; Torres-Fuentes C
+Authors Full Name
+ Avila-Roman, Javier; Arreaza-Gil, Veronica; Cortes-Espinar, Antonio J; Soliz-Rueda, Jorge R; Mulero, Miquel; Muguerza, Begona; Arola-Arnal, Anna; Arola, Lluis; Torres-Fuentes, Cristina.
+Institution
+ Avila-Roman, Javier. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: franciscojavier.avila@urv.cat.
+ Arreaza-Gil, Veronica. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: veronica.arreaza@urv.cat.
+ Cortes-Espinar, Antonio J. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: antoniojesus.cortes@urv.cat.
+ Soliz-Rueda, Jorge R. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: jorgericardo.soliz@urv.cat.
+ Mulero, Miquel. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: miquel.mulero@urv.cat.
+ Muguerza, Begona. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: begona.muguerza@urv.cat.
+ Arola-Arnal, Anna. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: anna.arola@urv.cat.
+ Arola, Lluis. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: lluis.arola@urv.cat.
+ Torres-Fuentes, Cristina. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 43007, Tarragona, Spain. Electronic address: cristina.torres@urv.cat.
+MeSH Subject Headings
+ Animals
+ Anti-Bacterial Agents/ad [Administration & Dosage]
+ Bacteria/cl [Classification]
+ Biomarkers/bl [Blood]
+ Diet/ae [Adverse Effects]
+ Diet/mt [Methods]
+ Disease Models, Animal
+ Dysbiosis/bl [Blood]
+ Dysbiosis/mi [Microbiology]
+ *Gastrointestinal Microbiome/ph [Physiology]
+ Inflammation
+ Male
+ Metabolomics
+ *Obesity/bl [Blood]
+ *Obesity/mi [Microbiology]
+ *Oxylipins/bl [Blood]
+ Rats
+ Rats, Wistar
+Keyword Heading
+ Cafeteria diet
+ Gut microbiota
+ Inflammation
+ Lipid mediators
+ Obesity
+ Oxylipins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: Oxylipins (OXLs) are bioactive lipid metabolites derived from polyunsaturated fatty acids (PUFAs) which act as signaling molecules and are involved in inflammatory processes such as those that occur in obesity. On the other hand, gut microbiota plays an essential role in regulating inflammatory responses. However, little is known about the potential impact of gut bacteria on OXLs metabolism. Thus, the objective of this study was to investigate the effect of gut microbiota dysbiosis on plasma oxylipins profile in healthy and diet-induced obese animals.
+
+ METHODS: Eight-week-old male Wistar rats were fed with either a standard or cafeteria diet (CAF) for 5 weeks and administered an antibiotic cocktail (ABX) in the drinking water (Ampicillin: 1 g/ml, Vancomycin: 0.5 g/ml, Imipenem: 0.25 g/ml) for the last 2 weeks in order to induce gut microbiota dysbiosis. Metabolomics analysis of OXLs in plasma was performed by HPLC-MS analysis. No antibiotic treated animals were included as controls.
+
+ RESULTS: Plasma OXLs profile was significantly altered due to both CAF feeding and ABX administration. ABX effect was more pronounced under obesogenic conditions. Several significant correlations between different bacteria taxa and these lipid mediators were observed. Among these, the positive correlation of Proteobacteria with LTB4, a proinflammatory OXL involved in obesity-related disorders, was especially remarkable.
+
+ CONCLUSIONS: Gut microbiota plays a key role in regulating these lipid metabolites and, therefore, affecting oxylipins-mediated inflammatory processes. These results are the first evidence to our knowledge of gut microbiota impact on OXLs metabolism. Moreover, this can set the basis for developing new obesity markers based on OXLs and gut microbiota profiles. Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Bacterial Agents). 0 (Biomarkers). 0 (Oxylipins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.clnu.2021.02.035
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Avila-Roman&issn=0261-5614&title=Clinical+Nutrition&atitle=Impact+of+gut+microbiota+on+plasma+oxylipins+profile+under+healthy+and+obesogenic+conditions.&volume=40&issue=4&spage=1475&epage=1486&date=2021&doi=10.1016%2Fj.clnu.2021.02.035&pmid=33743282&sid=OVID:medline
+
+<931>
+Unique Identifier
+ 33742062
+Title
+ Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19.
+Source
+ Scientific Reports. 11(1):6428, 2021 03 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moin ASM; Sathyapalan T; Diboun I; Atkin SL; Butler AE
+Authors Full Name
+ Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Diboun, Ilhame; Atkin, Stephen L; Butler, Alexandra E.
+Institution
+ Moin, Abu Saleh Md. Diabetes Research Center (DRC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar.
+ Sathyapalan, Thozhukat. Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Hull, UK.
+ Diboun, Ilhame. Hamad Bin Khalifa University (HBKU), Doha, Qatar.
+ Atkin, Stephen L. Royal College of Surgeons in Ireland Bahrain, Adliya, Kingdom of Bahrain.
+ Butler, Alexandra E. Diabetes Research Center (DRC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar. aeb91011@gmail.com.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ COVID-19/bl [Blood]
+ *COVID-19/et [Etiology]
+ COVID-19/im [Immunology]
+ Cytokines/bl [Blood]
+ Cytokines/im [Immunology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/im [Immunology]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/co [Complications]
+ Inflammation/im [Immunology]
+ *Macrophage Activation
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/im [Immunology]
+ Pilot Projects
+ Prospective Studies
+ Risk Factors
+Abstract
+ Hyperactivation of the immune system through obesity and diabetes may enhance infection severity complicated by Acute Respiratory Distress Syndrome (ARDS). The objective was to determine the circulatory biomarkers for macrophage activation at baseline and after serum glucose normalization in obese type 2 diabetes (OT2D) subjects. A case-controlled interventional pilot study in OT2D (n = 23) and control subjects (n = 23). OT2D subjects underwent hyperinsulinemic clamp to normalize serum glucose. Plasma macrophage-related proteins were determined using Slow Off-rate Modified Aptamer-scan plasma protein measurement at baseline (control and OT2D subjects) and after 1-h of insulin clamp (OT2D subjects only). Basal M1 macrophage activation was characterized by elevated levels of M1 macrophage-specific surface proteins, CD80 and CD38, and cytokines or chemokines (CXCL1, CXCL5, RANTES) released by activated M1 macrophages. Two potent M1 macrophage activation markers, CXCL9 and CXCL10, were decreased in OT2D. Activated M2 macrophages were characterized by elevated levels of plasma CD163, TFGbeta-1, MMP7 and MMP9 in OT2D. Conventional mediators of both M1 and M2 macrophage activation markers (IFN-gamma, IL-4, IL-13) were not altered. No changes were observed in plasma levels of M1/M2 macrophage activation markers in OT2D in response to acute normalization of glycemia. In the basal state, macrophage activation markers are elevated, and these reflect the expression of circulatory cytokines, chemokines, growth factors and matrix metalloproteinases in obese individuals with type 2 diabetes, that were not changed by glucose normalisation. These differences could potentially predispose diabetic individuals to increased infection severity complicated by ARDS. Clinical trial reg. no: NCT03102801; registration date April 6, 2017.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-85760-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moin&issn=2045-2322&title=Scientific+Reports&atitle=Identification+of+macrophage+activation-related+biomarkers+in+obese+type+2+diabetes+that+may+be+indicative+of+enhanced+respiratory+risk+in+COVID-19.&volume=11&issue=1&spage=6428&epage=&date=2021&doi=10.1038%2Fs41598-021-85760-y&pmid=33742062&sid=OVID:medline
+
+<932>
+Unique Identifier
+ 33740389
+Title
+ The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes: a randomized trial.
+Source
+ Applied Physiology, Nutrition, & Metabolism = Physiologie Appliquee, Nutrition et Metabolisme. 46(9):1133-1142, 2021 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sondergard SD; Cintin I; Kuhlman AB; Morville TH; Bergmann ML; Kjaer LK; Poulsen HE; Giustarini D; Rossi R; Dela F; Helge JW; Larsen S
+Authors Full Name
+ Sondergard, Stine D; Cintin, Ida; Kuhlman, Anja B; Morville, Thomas H; Bergmann, Marie Louise; Kjaer, Laura K; Poulsen, Henrik E; Giustarini, Daniela; Rossi, Ranieri; Dela, Flemming; Helge, Jorn W; Larsen, Steen.
+Institution
+ Sondergard, Stine D. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Cintin, Ida. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Kuhlman, Anja B. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Morville, Thomas H. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Morville, Thomas H. Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
+ Bergmann, Marie Louise. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Kjaer, Laura K. Laboratory of Clinical Pharmacology, Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
+ Poulsen, Henrik E. Laboratory of Clinical Pharmacology, Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
+ Giustarini, Daniela. Department of Biotechnology Chemistry and Pharmacy, University of Siena, Siena, Italy.
+ Rossi, Ranieri. Department of Biotechnology Chemistry and Pharmacy, University of Siena, Siena, Italy.
+ Dela, Flemming. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Dela, Flemming. Department of Geriatrics, Bispebjerg University Hospital, Copenhagen, Denmark.
+ Helge, Jorn W. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Larsen, Steen. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Larsen, Steen. Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
+MeSH Subject Headings
+ Administration, Oral
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Dietary Supplements/ae [Adverse Effects]
+ *Dietary Supplements
+ Glucose Tolerance Test
+ *Glutathione/ad [Administration & Dosage]
+ Glutathione/ae [Adverse Effects]
+ Glutathione/bl [Blood]
+ Glutathione/me [Metabolism]
+ Glutathione Disulfide/me [Metabolism]
+ Humans
+ Hydrogen Peroxide/me [Metabolism]
+ *Insulin Resistance/ph [Physiology]
+ Middle Aged
+ Mitochondria, Muscle/me [Metabolism]
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Oxidative Stress
+ Oxygen Consumption
+Keyword Heading
+ glutathion
+ glutathione
+ insulin sensitivity
+ mitochondria
+ mitochondries
+ oxidative stress
+ sensibilite a l'insuline
+ stress oxydatif
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The effect of oral glutathione (GSH) supplementation was studied in obese subjects with and without type 2 diabetes (T2DM) on measures of glucose homeostasis and markers of oxidative stress. Twenty subjects (10 patients with T2DM and 10 obese subjects) were recruited for the study, and randomized in a double-blinded placebo-controlled manner to consume either 1000 mg GSH per day or placebo for 3 weeks. Before and after the 3 weeks insulin sensitivity was measured with the hyperinsulinemic-euglycemic clamp and a muscle biopsy was obtained to measure GSH and skeletal muscle mitochondrial hydrogen peroxide (H2O2) emission rate. Whole body insulin sensitivity increased significantly in the GSH group. Skeletal muscle GSH was numerically increased (~19%) in the GSH group; no change was seen in GSH to glutathione disulfide ratio. Skeletal muscle mitochondrial H2O2 emission rate did not change in response to the intervention and neither did the urinary excretion of the RNA oxidation product 8-oxo-7,8-dihydroguanosine or the DNA oxidation product 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), although 8-oxodG decreased as a main effect of time. Oral GSH supplementation improves insulin sensitivity in obese subjects with and without T2DM, although it does not alter markers of oxidative stress. The study has been registered in clinicaltrials.gov (NCT02948673). Novelty: Reduced glutathione supplementation increases insulin sensitivity in obese subjects with and without T2DM. H2O2 emission rate from skeletal muscle mitochondria was not affected by GSH supplementation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). BBX060AN9V (Hydrogen Peroxide). GAN16C9B8O (Glutathione). ULW86O013H (Glutathione Disulfide).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1139%2fapnm-2020-1099
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sondergard&issn=1715-5312&title=Applied+Physiology%2C+Nutrition%2C+%26+Metabolism+%3D+Physiologie+Appliquee%2C+Nutrition+et+Metabolisme&atitle=The+effects+of+3+weeks+of+oral+glutathione+supplementation+on+whole+body+insulin+sensitivity+in+obese+males+with+and+without+type+2+diabetes%3A+a+randomized+trial.&volume=46&issue=9&spage=1133&epage=1142&date=2021&doi=10.1139%2Fapnm-2020-1099&pmid=33740389&sid=OVID:medline
+
+<933>
+Unique Identifier
+ 33729834
+Title
+ Liver injury after small bowel resection is prevented in obesity-resistant 129S1/SvImJ mice.
+Source
+ American Journal of Physiology - Gastrointestinal & Liver Physiology. 320(5):G907-G918, 2021 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Onufer EJ; Han YH; Courtney C; Steinberger A; Tecos M; Sutton S; Sescleifer A; Ou J; Sanguinetti Czepielewski R; Randolph GJ; Warner BW
+Author NameID
+ Onufer, Emily J; ORCID: https://orcid.org/0000-0002-8802-5346
+Authors Full Name
+ Onufer, Emily J; Han, Yong-Hyun; Courtney, Cathleen; Steinberger, Allie; Tecos, Maria; Sutton, Stephanie; Sescleifer, Anne; Ou, Jocelyn; Sanguinetti Czepielewski, Rafael; Randolph, Gwendalyn J; Warner, Brad W.
+Institution
+ Onufer, Emily J. Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Han, Yong-Hyun. Laboratory of Pathology and Physiology, College of Pharmacy, Kangwon National University, Chuncheon, South Korea.
+ Han, Yong-Hyun. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
+ Courtney, Cathleen. Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Steinberger, Allie. Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Tecos, Maria. Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Sutton, Stephanie. Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Sescleifer, Anne. Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Ou, Jocelyn. Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+ Sanguinetti Czepielewski, Rafael. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
+ Randolph, Gwendalyn J. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
+ Warner, Brad W. Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
+MeSH Subject Headings
+ Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ Digestive System Surgical Procedures
+ Disease Models, Animal
+ Endotoxins/bl [Blood]
+ Fatty Acids, Nonesterified/me [Metabolism]
+ Intestine, Small/su [Surgery]
+ Lipids/bl [Blood]
+ *Liver/me [Metabolism]
+ Liver Cirrhosis/me [Metabolism]
+ *Liver Diseases/et [Etiology]
+ Liver Diseases/me [Metabolism]
+ Mice
+ Mice, Inbred C57BL
+ Obesity/me [Metabolism]
+ *Short Bowel Syndrome/me [Metabolism]
+ Triglycerides/me [Metabolism]
+Keyword Heading
+ intestinal failure-associated liver disease
+ short bowel syndrome
+ small bowel resection
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Intestinal failure-associated liver disease is a major morbidity associated with short bowel syndrome. We sought to determine if the obesity-resistant mouse strain (129S1/SvImJ) conferred protection from liver injury after small bowel resection (SBR). Using a parenteral nutrition-independent model of resection-associated liver injury, C57BL/6J and 129S1/SvImJ mice underwent a 50% proximal SBR or sham operation. At postoperative week 10, hepatic steatosis, fibrosis, and cholestasis were assessed. Hepatic and systemic inflammatory pathways were evaluated using oxidative markers and abundance of tissue macrophages. Potential mechanisms of endotoxin resistance were also explored. Serum lipid levels were elevated in all mouse lines. Hepatic triglyceride levels were no different between mouse strains, but there was an increased accumulation of free fatty acids in the C57BL/6J mice. Histological and serum markers of hepatic fibrosis, steatosis, and cholestasis were significantly elevated in resected C57BL/6J SBR mice as well as oxidative stress markers and macrophage recruitment in both the liver and visceral white fat in C57BL/6J mice compared with sham controls and the 129S1/SvImJ mouse line. Serum endotoxin levels were significantly elevated in C57BL/6J mice with significant elevation of hepatic TLR4 and reduction in PPARalpha expression levels. Despite high levels of serum lipids, 129S1/SvImJ mice did not develop liver inflammation, fibrosis, or cholestasis after SBR, unlike C57BL/6J mice. These data suggest that the accumulation of hepatic free fatty acids as well as increased endotoxin-driven inflammatory pathways through PPARalpha and TLR4 contribute to the liver injury seen in C57BL/6J mice with short bowel syndrome. NEW & NOTEWORTHY Unlike C57BL/6 mice, the 129S1/SvImJ strain is resistant to liver inflammation and injury after small bowel resection. These disparate outcomes are likely due to the accumulation of hepatic free fatty acids as well as increased endotoxin-driven inflammatory pathways through PPARalpha and TLR4 in C57BL/6 mice with short bowel syndrome.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Endotoxins). 0 (Fatty Acids, Nonesterified). 0 (Lipids). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1152%2fajpgi.00284.2020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Onufer&issn=0193-1857&title=American+Journal+of+Physiology+-+Gastrointestinal+%26+Liver+Physiology&atitle=Liver+injury+after+small+bowel+resection+is+prevented+in+obesity-resistant+129S1%2FSvImJ+mice.&volume=320&issue=5&spage=G907&epage=G918&date=2021&doi=10.1152%2Fajpgi.00284.2020&pmid=33729834&sid=OVID:medline
+
+<934>
+Unique Identifier
+ 33728817
+Title
+ Fasting plasma glucose and risk of type 2 diabetes mellitus in a group of Chinese people with normoglycemia and without obesity.
+Source
+ Journal Of Diabetes. 13(7):601-602, 2021 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang Z; Liu Z; He S
+Author NameID
+ He, Sen; ORCID: https://orcid.org/0000-0002-9777-2650
+Authors Full Name
+ Wang, Ziqiong; Liu, Zheng; He, Sen.
+Institution
+ Wang, Ziqiong. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China.
+ Liu, Zheng. Nursing Department, West China School of Nursing, West China Hospital of Sichuan University, Chengdu, China.
+ He, Sen. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ *Blood Glucose/an [Analysis]
+ China/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ *Fasting
+ Humans
+ *Obesity/pp [Physiopathology]
+ Prediabetic State/bl [Blood]
+ *Prediabetic State/ep [Epidemiology]
+ Prediabetic State/pa [Pathology]
+ Prognosis
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Letter.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2f1753-0407.13180
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1753-0407&title=Journal+Of+Diabetes&atitle=Fasting+plasma+glucose+and+risk+of+type+2+diabetes+mellitus+in+a+group+of+Chinese+people+with+normoglycemia+and+without+obesity.&volume=13&issue=7&spage=601&epage=602&date=2021&doi=10.1111%2F1753-0407.13180&pmid=33728817&sid=OVID:medline
+
+<935>
+Unique Identifier
+ 33727589
+Title
+ Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
+Source
+ Scientific Reports. 11(1):5991, 2021 03 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nunoue T; Yamaguchi S; Teshigawara S; Katayama A; Nakatsuka A; Eguchi J; Niki T; Wada J
+Authors Full Name
+ Nunoue, Tomokazu; Yamaguchi, Satoshi; Teshigawara, Sanae; Katayama, Akihiro; Nakatsuka, Atsuko; Eguchi, Jun; Niki, Toshiro; Wada, Jun.
+Institution
+ Nunoue, Tomokazu. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
+ Yamaguchi, Satoshi. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
+ Teshigawara, Sanae. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
+ Katayama, Akihiro. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
+ Nakatsuka, Atsuko. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
+ Eguchi, Jun. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
+ Niki, Toshiro. Department of Immunology, Kagawa University, Takamatsu, Kagawa, Japan.
+ Wada, Jun. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. junwada@okayama-u.ac.jp.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Animals
+ Biomarkers
+ Body Weight
+ Disease Models, Animal
+ *Disease Susceptibility
+ *Galectins/df [Deficiency]
+ Galectins/me [Metabolism]
+ Glucose/me [Metabolism]
+ Lipid Metabolism
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Mice
+ Mice, Knockout
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Oxidation-Reduction
+ *Peroxiredoxins/me [Metabolism]
+ Protein Binding
+ RNA, Small Interfering/ge [Genetics]
+Abstract
+ The adipose tissue is regarded as an endocrine organ and secretes bioactive adipokines modulating chronic inflammation and oxidative stress in obesity. Gal-9 is secreted out upon cell injuries, interacts with T-cell immunoglobulin-3 (Tim-3) and induces apoptosis in activated Th1 cells. Gal-9 also binds to protein disulfide isomerase (PDI), maintains PDI on surface of T cells, and increases free thiols in the disulfide/thiol cycles. To explore the molecular mechanism of obesity, we investigated Gal-9-/- and Gal-9wt/wt C57BL/6J mice fed with high fat-high sucrose (HFHS) chow. Gal-9-/- mice were resistant to diet-induced obesity associated with reduction of epididymal and mesenteric fat tissues and improved glucose tolerance compared with Gal-9wt/wt mice. However, the number of M1, M2 macrophages, and M1/M2 ratio in epididymal fat were unaltered. Under HFHS chow, Gal-9-/- mice receiving Gal-9-/- or Gal-9wt/wt bone marrow-derived cells (BMCs) demonstrated significantly lower body weight compared with Gal-9wt/wt mice receiving Gal-9-/- BMCs. We identified the binding between Gal-9 and peroxiredoxin-2 (PRDX2) in sugar chain-independent manner by nanoLC-MS/MS, immunoprecipitation, and pull-down assay. In 3T3L1 adipocytes, Gal-9 knockdown shifts PRDX2 monomer (reduced form) dominant from PRDX2 dimer (oxidized form) under oxidative stress with H2O2. The inhibition of Gal-9 in adipocytes may be a new therapeutic approach targeting the oxidative stress and subsequent glucose intolerance in obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Galectins). 0 (LGALS9 protein, mouse). 0 (RNA, Small Interfering). EC 1-11-1-15 (Peroxiredoxins). EC 1-11-1-15 (Prdx2 protein, mouse). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-85080-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nunoue&issn=2045-2322&title=Scientific+Reports&atitle=Lgals9+deficiency+ameliorates+obesity+by+modulating+redox+state+of+PRDX2.&volume=11&issue=1&spage=5991&epage=&date=2021&doi=10.1038%2Fs41598-021-85080-1&pmid=33727589&sid=OVID:medline
+
+<936>
+Unique Identifier
+ 33721297
+Title
+ Evaluation of the Efficacy of Sex Hormone-Binding Globulin in Insulin Resistance Assessment Based on HOMA-IR in Patients with PCOS.
+Source
+ Reproductive Sciences. 28(9):2504-2513, 2021 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen F; Liao Y; Chen M; Yin H; Chen G; Huang Q; Chen L; Yang X; Zhang W; Wang P; Yin G
+Author NameID
+ Yin, Guoshu; ORCID: http://orcid.org/0000-0002-5006-3486
+Authors Full Name
+ Chen, Fu; Liao, Yingyang; Chen, Minjie; Yin, Huihuang; Chen, Guishan; Huang, Qingxia; Chen, Lan; Yang, Xiaoping; Zhang, Weichun; Wang, Ping; Yin, Guoshu.
+Institution
+ Chen, Fu. Department of Clinical Nutrition, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Liao, Yingyang. Department of Nutrition, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China.
+ Chen, Minjie. Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Chen, Minjie. Laboratory of Molecular Cardiology and Laboratory of Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Yin, Huihuang. Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Yin, Huihuang. Laboratory of Molecular Cardiology and Laboratory of Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Chen, Guishan. Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Huang, Qingxia. Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Chen, Lan. Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Yang, Xiaoping. Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Zhang, Weichun. Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Zhang, Weichun. Laboratory of Molecular Cardiology and Laboratory of Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
+ Wang, Ping. Department of Endocrinology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, Hainan Province, China.
+ Yin, Guoshu. Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China. yinguoshu@126.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ Female
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ Polycystic Ovary Syndrome/pp [Physiopathology]
+ Predictive Value of Tests
+ *Sex Hormone-Binding Globulin/an [Analysis]
+Keyword Heading
+ HOMA-IR
+ Insulin resistance (IR)
+ Polycystic ovary syndrome (PCOS)
+ Predictive marker
+ ROC curve
+ Sex hormone-binding globulin (SHBG)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study aimed to evaluate the efficacy of SHBG in predicting insulin resistance (IR) in newly diagnosed, untreated patients with polycystic ovary syndrome (PCOS). Hundred newly diagnosed, untreated patients with PCOS and 61 subjects without PCOS (41 healthy volunteers with normal BMI and 20 subjects with overweight/obese) were included in the study. Receiver-operating characteristic (ROC) analysis was used to assess the effectiveness of SHBG in predicting IR in overweight/obese and non-overweight PCOS patients and the optimal cut-off values of SHBG. The results showed negative correlations between log-SHBG and log-I0 (r = - 0.372, P < 0.001) and log-SHBG and log-Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (r = - 0.393, P < 0.001) after adjusting for blood pressure, serum lipid, age, and body mass index (BMI) in all of the PCOS patients. In patients with IR (defined as HOMA-IR >=2.29), the area under the ROC curves (AUCs) of the SHBG for ROC analysis in the non-overweight group, overweight/obese group, and all PCOS patients were 0.774 (P = 0.0001), 0.922 (P = 0.0001), and 0.885 (P = 0.0001), respectively. The optimal cut-off value of SHBG was 37 nmol/L with a sensitivity of 97.62% and specificity of 80.85% in the overweight group. In patients with IR (HOMA-IR >=2.5), the AUCs of SHBG for ROC analysis in the non-overweight group, overweight/obese group, and all PCOS patients were 0.741 (P = 0.0003), 0.928 (P = 0.0001), and 0.880 (P = 0.0001), respectively. The optimal cut-off value of SHBG was 30.2 nmol/L with a sensitivity of 97.44% and specificity of 82.69% in the overweight/obese group. In conclusion, this study observed a negative correlation between SHBG and HOMA-IR in PCOS patients after adjustment of confounding factors. SHBG was an independent influential factor of HOMA-IR and can be used as a positive predictive marker for IR in PCOS patients, especially in those who are overweight/obese. Copyright © 2021. Society for Reproductive Investigation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (SHBG protein, human). 0 (Sex Hormone-Binding Globulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs43032-021-00535-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1933-7191&title=Reproductive+Sciences&atitle=Evaluation+of+the+Efficacy+of+Sex+Hormone-Binding+Globulin+in+Insulin+Resistance+Assessment+Based+on+HOMA-IR+in+Patients+with+PCOS.&volume=28&issue=9&spage=2504&epage=2513&date=2021&doi=10.1007%2Fs43032-021-00535-0&pmid=33721297&sid=OVID:medline
+
+<937>
+Unique Identifier
+ 33719195
+Title
+ Left ventricular hypertrophy predicts poorer cardiovascular outcome in normotensive normoglycemic patients with rheumatoid arthritis.
+Source
+ International Journal of Rheumatic Diseases. 24(4):510-518, 2021 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cioffi G; Viapiana O; Orsolini G; Ognibeni Sonographer F; Dalbeni A; Gatti D; Adami G; Fassio A; Rossini M; Giollo A
+Author NameID
+ Cioffi, Giovanni; ORCID: https://orcid.org/0000-0002-2805-9982
+Authors Full Name
+ Cioffi, Giovanni; Viapiana, Ombretta; Orsolini, Giovanni; Ognibeni Sonographer, Federica; Dalbeni, Andrea; Gatti, Davide; Adami, Giovanni; Fassio, Angelo; Rossini, Maurizio; Giollo, Alessandro.
+Institution
+ Cioffi, Giovanni. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+ Cioffi, Giovanni. Division of Cardiac Rehabilitation, S. Pancrazio Hospital, Trento, Italy.
+ Viapiana, Ombretta. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+ Orsolini, Giovanni. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+ Ognibeni Sonographer, Federica. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+ Dalbeni, Andrea. Department of Medicine, General Medicine and Hypertension and Liver Unit, University of Verona & Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
+ Gatti, Davide. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+ Adami, Giovanni. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+ Fassio, Angelo. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+ Rossini, Maurizio. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+ Giollo, Alessandro. Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Aged
+ *Arthritis, Rheumatoid/ep [Epidemiology]
+ Arthritis, Rheumatoid/mo [Mortality]
+ Arthritis, Rheumatoid/th [Therapy]
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Disease Progression
+ Female
+ Hospitalization
+ Humans
+ *Hypertrophy, Left Ventricular/ep [Epidemiology]
+ Hypertrophy, Left Ventricular/mo [Mortality]
+ Hypertrophy, Left Ventricular/pp [Physiopathology]
+ Hypertrophy, Left Ventricular/pc [Prevention & Control]
+ Italy/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Primary Prevention
+ Prognosis
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Time Factors
+ *Ventricular Function, Left
+ *Ventricular Remodeling
+Keyword Heading
+ ACPA
+ cardiovascular risk
+ left ventricular hypertrophy
+ prognosis
+ rheumatoid arthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Patients with rheumatoid arthritis (RA) develop early changes in left ventricular (LV) geometry and experience cardiovascular events in excess than in the general population. This study was designed to assess prevalence, predictors and prognostic role of LV hypertrophy (LVH) in a selected group of RA patients with normal blood pressure and glycemia who should be at low risk for LVH.
+
+ METHODS: We prospectively analyzed 241 normotensive normoglycemic RA patients (mean age 53 +/- 12 years, 61% women) involved in a primary prevention program for cardiovascular diseases who were followed-up for 40 (24-56) months. LVH was detected by echocardiography and defined as LV mass >=49.2 g/m2.7 for men and >=46.7 g/m2.7 for women. Primary outcome was a composite of cardiovascular death/hospitalization.
+
+ RESULTS: LVH was detected in 39 patients (16%). Older age (>53 years), greater body mass index (BMI > 25 kg/m2 ), longer duration of RA disease, anti-cyclic citrullinated peptide antibody (ACPA) positivity and concentric LV geometry were the variables associated with LVH. During the follow-up, a cardiovascular event occurred in 12 of 39 (31%) patients with LVH and in 22 of 202 (11%; P < .001) patients without LVH. LVH independently predicted cardiovascular events (hazards ratio 3.28 [95% CI 1.03-9.20], P = .03) at Cox regression analysis together with C-reactive protein and ACPA positivity.
+
+ CONCLUSIONS: Nearly one-sixth of normotensive normoglycemic RA patients analyzed in a primary prevention program for cardiovascular diseases has LVH which is associated with obesity and older age, and strongly predicts cardiovascular event in these subjects. Copyright © 2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2f1756-185X.14082
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cioffi&issn=1756-1841&title=International+Journal+of+Rheumatic+Diseases&atitle=Left+ventricular+hypertrophy+predicts+poorer+cardiovascular+outcome+in+normotensive+normoglycemic+patients+with+rheumatoid+arthritis.&volume=24&issue=4&spage=510&epage=518&date=2021&doi=10.1111%2F1756-185X.14082&pmid=33719195&sid=OVID:medline
+
+<938>
+Unique Identifier
+ 33717095
+Title
+ Clusterin and Its Role in Insulin Resistance and the Cardiometabolic Syndrome. [Review]
+Source
+ Frontiers in Immunology. 12:612496, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wittwer J; Bradley D
+Authors Full Name
+ Wittwer, Jennifer; Bradley, David.
+Institution
+ Wittwer, Jennifer. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center, The Ohio State University, Columbus, OH, United States.
+ Bradley, David. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center, The Ohio State University, Columbus, OH, United States.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ Clusterin/bl [Blood]
+ Clusterin/ge [Genetics]
+ *Clusterin/me [Metabolism]
+ *Disease Susceptibility
+ Gene Expression Regulation
+ Humans
+ Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ Insulin Resistance/ge [Genetics]
+ *Insulin Resistance
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/et [Etiology]
+ *Metabolic Syndrome/me [Metabolism]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+Keyword Heading
+ adipocyte
+ cardiometabolic disease
+ clusterin
+ inflammation
+ type 2 ddiabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The cardiometabolic syndrome involves a clustering of metabolic and cardiovascular factors which increase the risk of patients developing both Type 2 Diabetes Mellitus and cardio/cerebrovascular disease. Although the mechanistic underpinnings of this link remain uncertain, key factors include insulin resistance, excess visceral adiposity, atherogenic dyslipidemia, and endothelial dysfunction. Of these, a state of resistance to insulin action in overweight/obese patients appears to be central to the pathophysiologic process. Given the increasing prevalence of obesity-related Type 2 Diabetes, coupled with the fact that cardiovascular disease is the number one cause of mortality in this patient population, a more thorough understanding of the cardiometabolic syndrome and potential options to mitigate its risk is imperative. Inherent in the pathogenesis of insulin resistance is an underlying state of chronic inflammation, at least partly in response to excess adiposity. Within obese adipose tissue, an immunomodulatory shift occurs, involving a preponderance of pro-inflammatory immune cells and cytokines/adipokines, along with antigen presentation by adipocytes. Therefore, various adipokines differentially expressed by obese adipocytes may have a significant effect on cardiometabolism. Clusterin is a molecular chaperone that is widely produced by many tissues throughout the body, but is also preferentially overexpressed by obese compared lean adipocytes and relates strongly to multiple components of the cardiometabolic syndrome. Herein, we summarize the known and potential roles of circulating and adipocyte-specific clusterin in cardiometabolism and discuss potential further investigations to determine if clusterin is a viable target to attenuate both metabolic and cardiovascular disease. Copyright © 2021 Wittwer and Bradley.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Clusterin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3389%2ffimmu.2021.612496
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wittwer&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Clusterin+and+Its+Role+in+Insulin+Resistance+and+the+Cardiometabolic+Syndrome.&volume=12&issue=&spage=612496&epage=&date=2021&doi=10.3389%2Ffimmu.2021.612496&pmid=33717095&sid=OVID:medline
+
+<939>
+Unique Identifier
+ 33711537
+Title
+ Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents.
+Source
+ Environment International. 151:106469, 2021 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Guil-Oumrait N; Valvi D; Garcia-Esteban R; Guxens M; Sunyer J; Torrent M; Casas M; Vrijheid M
+Authors Full Name
+ Guil-Oumrait, Nuria; Valvi, Damaskini; Garcia-Esteban, Raquel; Guxens, Monica; Sunyer, Jordi; Torrent, Maties; Casas, Maribel; Vrijheid, Martine.
+Institution
+ Guil-Oumrait, Nuria. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain. Electronic address: nuria.guil@isglobal.org.
+ Valvi, Damaskini. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: dania.valvi@mssm.edu.
+ Garcia-Esteban, Raquel. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: raquel.garcia@isglobal.org.
+ Guxens, Monica. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. Electronic address: monica.guxens@isglobal.org.
+ Sunyer, Jordi. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain; IMIM-Parc Salut Mar, Barcelona, Catalonia, Spain. Electronic address: jordi.sunyer@isglobal.org.
+ Torrent, Maties. Ib-salut, Area de Salut de Menorca, Menorca, Spain. Electronic address: maties.torrent@ssib.es.
+ Casas, Maribel. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: maribel.casas@isglobal.org.
+ Vrijheid, Martine. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: martine.vrijheid@isglobal.org.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Child
+ Child, Preschool
+ Cohort Studies
+ Environmental Pollutants/to [Toxicity]
+ *Environmental Pollutants
+ Female
+ Humans
+ Longitudinal Studies
+ Obesity/ep [Epidemiology]
+ Persistent Organic Pollutants
+ Pregnancy
+ Prenatal Exposure Delayed Effects/ep [Epidemiology]
+ *Prenatal Exposure Delayed Effects
+ Spain/ep [Epidemiology]
+Keyword Heading
+ Cardiometabolic syndrome
+ Dichlorodiphenyltrichloroethane (p,p'-DDT)
+ Endocrine disruptors
+ Hexachlorobenzene (HCB)
+ Persistent organic pollutants (POPs)
+ Polychlorinated biphenyls (PCBs)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs) has been linked to cardiometabolic (CM) risk factors in childhood, but there are no studies evaluating the persistence of these associations into adolescence, a period of relevant changes in endocrine-dependent organ systems and rapid increases in lean and fat mass. We examined the associations of prenatal POP exposures with body mass index (BMI) from age 4 to 18 years, and with other CM risk markers in adolescence.
+
+ METHODS: We analysed 379 children from the Spanish INMA-Menorca birth cohort study with measured cord blood POP concentrations. We calculated BMI z-scores at ages 4, 6, 11, 14 and 18 years using the WHO growth reference. Body fat % was measured at 11 and 18 years and waist-to-height ratio (WHtR) and blood pressure (BP) at 11, 14 and 18 years. We measured CM biomarkers in fasting blood collected at age 14 years and calculated a CM-risk score as the sum of the sex-, and age-specific z-scores for waist circumference, mean arterial BP, homeostatic model assessment of insulin resistance, fasting blood triglycerides, and high-density lipoprotein cholesterol (HDL-C) (n = 217). Generalised estimating equations and multivariate linear regression models assessed the associations with repeated and single time-point measures, respectively.
+
+ RESULTS: Hexachlorobenzene (HCB) exposure in the third tertile, compared to the first tertile, was associated with higher BMI (beta = 0.24; 95% CI: 0.01, 0.47) and WHtR z-score (beta = 0.27; 95% CI: 0.04, 0.51). A continuous increase in HCB was associated with an elevated body fat % (beta per 10-fold increase = 4.21; 95% CI: 0.51, 7.92), systolic BP (beta = 0.32; 95% CI: 0.02, 0.64) and diastolic BP z-score (beta = 0.32; 95% CI: 0.02, 0.62) across all ages, and with higher CM-risk score (beta = 1.59; 95% CI: 0.02, 3.18) and lipid biomarkers (total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C)) at 14 years. Dichlorodiphenyltrichloroethane (p,p'-DDT) exposure was non-monotonically associated with BMI and systolic BP. p,p'-DDE and SIGMA-polychlorinated biphenyls (PCBs) (sum of congeners 118, 138, 153, 180) were not associated with adiposity or BP. p,p'-DDT exposure was associated with an increased CM-risk score, and SIGMAPCBs concentrations with LDL-C in all adolescents and with total cholesterol only in girls (p-sex interaction = 0.05).
+
+ CONCLUSION: This first longitudinal study from 4 to 18 years suggests that the previously reported POP associations with child BMI persist later in adolescence and that prenatal POP exposures are associated with major risk factors for adult CM syndrome. Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Environmental Pollutants).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.envint.2021.106469
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Guil-Oumrait&issn=0160-4120&title=Environment+International&atitle=Prenatal+exposure+to+persistent+organic+pollutants+and+markers+of+obesity+and+cardiometabolic+risk+in+Spanish+adolescents.&volume=151&issue=&spage=106469&epage=&date=2021&doi=10.1016%2Fj.envint.2021.106469&pmid=33711537&sid=OVID:medline
+
+<940>
+Unique Identifier
+ 33711221
+Title
+ Investigating the relationship between insulin resistance and adipose tissue in a randomized Tehrani population.
+Source
+ Hormone Molecular Biology & Clinical Investigation. 42(3):235-244, 2021 Mar 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mirzay Razzaz J; Moameri H; Akbarzadeh Z; Ariya M; Hosseini SA; Ghaemi A; Osati S; Ehrampoush E; Homayounfar R
+Authors Full Name
+ Mirzay Razzaz, Jalaledin; Moameri, Hossein; Akbarzadeh, Zahra; Ariya, Mohammad; Hosseini, Seyed Ali; Ghaemi, Alireza; Osati, Saeed; Ehrampoush, Elham; Homayounfar, Reza.
+Institution
+ Mirzay Razzaz, Jalaledin. National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Moameri, Hossein. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Akbarzadeh, Zahra. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Ariya, Mohammad. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
+ Hosseini, Seyed Ali. Students Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
+ Ghaemi, Alireza. Department of Basic Sciences and Nutrition, Health Sciences Research Center, Addiction Institute, Faculty of Public Health, Mazandaran University of Medical Sciences, Sari, Iran.
+ Osati, Saeed. National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Ehrampoush, Elham. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
+ Ehrampoush, Elham. Department of Nutrition, Fasa University of Medical Sciences, Fasa, Iran.
+ Homayounfar, Reza. National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Homayounfar, Reza. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
+ Homayounfar, Reza. Department of Nutrition, Fasa University of Medical Sciences, Fasa, Iran.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Adult
+ Biomarkers
+ Body Composition
+ Body Mass Index
+ Body Weights and Measures
+ Cross-Sectional Studies
+ Diet
+ Female
+ Humans
+ *Insulin Resistance
+ Iran/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Odds Ratio
+ Public Health Surveillance
+ ROC Curve
+ Young Adult
+Keyword Heading
+ HOMA-IR
+ abdominal obesity
+ adipose tissue
+ insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Insulin resistance is the most common metabolic change associated with obesity. The present study aimed to investigate the relationship between insulin resistance and body composition especially adipose tissue in a randomized Tehrani population.
+
+ METHODS: This study used data of 2,160 individuals registered in a cross-sectional study on were randomly selected from among subjects who were referred to nutrition counseling clinic in Tehran, from April 2016 to September 2017. Insulin resistance was calculated by homeostasis model assessment formula. The odds ratio (95% CI) was calculated using logistic regression models.
+
+ RESULTS: The mean age of the men was 39 (+/-10) and women were 41 (+/-11) (the age ranged from 20 to 50 years). The risk of increased HOMA-IR was 1.03 (95% CI: 1.01-1.04) for an increase in one percent of Body fat, and 1.03 (95% CI: 1.00-1.05) for an increase in one percent of Trunk fat. Moreover, the odds ratio of FBS for an increase in one unit of Body fat percent and Trunk fat percent increased by 1.05 (adjusted odds ratio [95% CI: 1.03, 1.06]) and 1.05 (95% CI: 1.02, 1.08). Also, the risk of increased Fasting Insulin was 1.05 (95% CI: 1.03-1.07) for an increase in one unit of Body fat percent, and 1.05 (95% CI: 1.02-1.08) for an increase in one unit of Trunk fat percent.
+
+ CONCLUSIONS: The findings of the present study showed that there was a significant relationship between HOMA-IR, Fasting blood sugar, Fasting Insulin, and 2 h Insulin with percent of Body fat, percent of Trunk fat. Copyright © 2021 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1515%2fhmbci-2020-0084
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mirzay+Razzaz&issn=1868-1883&title=Hormone+Molecular+Biology+%26+Clinical+Investigation&atitle=Investigating+the+relationship+between+insulin+resistance+and+adipose+tissue+in+a+randomized+Tehrani+population.&volume=42&issue=3&spage=235&epage=244&date=2021&doi=10.1515%2Fhmbci-2020-0084&pmid=33711221&sid=OVID:medline
+
+<941>
+Unique Identifier
+ 33708209
+Title
+ Phenotypic and Functional Characterization of Double Negative B Cells in the Blood of Individuals With Obesity.
+Source
+ Frontiers in Immunology. 12:616650, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Frasca D; Diaz A; Romero M; Blomberg BB
+Authors Full Name
+ Frasca, Daniela; Diaz, Alain; Romero, Maria; Blomberg, Bonnie B.
+Institution
+ Frasca, Daniela. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Frasca, Daniela. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Diaz, Alain. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Romero, Maria. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Blomberg, Bonnie B. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Blomberg, Bonnie B. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States.
+MeSH Subject Headings
+ Adult
+ Autoantibodies/bl [Blood]
+ Autoantibodies/im [Immunology]
+ Autoantigens/im [Immunology]
+ Autoimmunity
+ B-Lymphocyte Subsets/im [Immunology]
+ B-Lymphocyte Subsets/me [Metabolism]
+ *B-Lymphocytes/im [Immunology]
+ *B-Lymphocytes/me [Metabolism]
+ *Biomarkers
+ Disease Susceptibility
+ Female
+ Humans
+ Immunoglobulin G/bl [Blood]
+ Immunoglobulin G/im [Immunology]
+ Immunophenotyping
+ Lymphocyte Count
+ Lymphocyte Depletion
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/im [Immunology]
+Keyword Heading
+ B cells
+ aging
+ antibody responses
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We have previously shown that obesity is associated with increased secretion of IgG antibodies with anti-self-reactivity. In this paper, we confirm and extend our previous findings. We show that the plasma of individuals with obesity is enriched in autoimmune antibodies whose levels are positively associated with blood frequencies of the subset of Double Negative (DN) B cells, which is the most pro-inflammatory B cell subset. We also show that DN B cells, significantly increased in the blood of obese versus lean individuals, are characterized by higher expression of immune activation markers and of the transcription factor T-bet, both associated with autoimmunity. The removal of DN B cells from the peripheral B cell pool significantly decreases in vitro secretion of anti-self IgG antibodies. These results altogether confirm the crucial role of DN B cells in the secretion of anti-self IgG antibodies in individuals with obesity. Copyright © 2021 Frasca, Diaz, Romero and Blomberg.
+Registry Number/Name of Substance
+ 0 (Autoantibodies). 0 (Autoantigens). 0 (Biomarkers). 0 (Immunoglobulin G).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3389%2ffimmu.2021.616650
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Frasca&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Phenotypic+and+Functional+Characterization+of+Double+Negative+B+Cells+in+the+Blood+of+Individuals+With+Obesity.&volume=12&issue=&spage=616650&epage=&date=2021&doi=10.3389%2Ffimmu.2021.616650&pmid=33708209&sid=OVID:medline
+
+<942>
+Unique Identifier
+ 33704552
+Title
+ Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data.
+Source
+ Clinical Research in Cardiology. 110(8):1280-1291, 2021 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Marcks N; Aimo A; Januzzi JL Jr; Vergaro G; Clerico A; Latini R; Meessen J; Anand IS; Cohn JN; Gravning J; Ueland T; Bayes-Genis A; Lupon J; de Boer RA; Yoshihisa A; Takeishi Y; Egstrup M; Gustafsson I; Gaggin HK; Eggers KM; Huber K; Tentzeris I; Ripoli A; Passino C; Sanders-van Wijk S; Emdin M; Brunner-La Rocca HP
+Author NameID
+ Brunner-La Rocca, Hans-Peter; ORCID: http://orcid.org/0000-0002-4356-8566
+Authors Full Name
+ Marcks, Nick; Aimo, Alberto; Januzzi, James L Jr; Vergaro, Giuseppe; Clerico, Aldo; Latini, Roberto; Meessen, Jennifer; Anand, Inder S; Cohn, Jay N; Gravning, Jorgen; Ueland, Thor; Bayes-Genis, Antoni; Lupon, Josep; de Boer, Rudolf A; Yoshihisa, Akiomi; Takeishi, Yasuchika; Egstrup, Michael; Gustafsson, Ida; Gaggin, Hanna K; Eggers, Kai M; Huber, Kurt; Tentzeris, Ioannis; Ripoli, Andrea; Passino, Claudio; Sanders-van Wijk, Sandra; Emdin, Michele; Brunner-La Rocca, Hans-Peter.
+Institution
+ Marcks, Nick. Department of Cardiology, Maastricht University Medical Centre, PO Box 5800, 6202AZ, Maastricht, The Netherlands.
+ Aimo, Alberto. Cardiology Division, University Hospital of Pisa, Pisa, Italy.
+ Januzzi, James L Jr. Massachusetts General Hospital and Baim Institute for Clinical Research, Boston, USA.
+ Vergaro, Giuseppe. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
+ Vergaro, Giuseppe. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Clerico, Aldo. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
+ Clerico, Aldo. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Latini, Roberto. Department of Cardiovascular Medicine, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy.
+ Meessen, Jennifer. Department of Cardiovascular Medicine, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy.
+ Anand, Inder S. Division of Cardiovascular Medicine, University of Minnesota, Minneapolis, USA.
+ Anand, Inder S. Department of Cardiology, VA Medical Centre, Minneapolis, USA.
+ Cohn, Jay N. Division of Cardiovascular Medicine, University of Minnesota, Minneapolis, USA.
+ Gravning, Jorgen. Department of Cardiology, Oslo University Hospital, Ulleval, Oslo, Norway.
+ Gravning, Jorgen. Centre for Heart Failure Research, University of Oslo, Oslo, Norway.
+ Ueland, Thor. Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
+ Ueland, Thor. Faculty of Medicine, University of Oslo, Oslo, Norway.
+ Ueland, Thor. K. G. Jebsen Thrombosis Research and Expertise Centre, University of Tromso, Tromso, Norway.
+ Bayes-Genis, Antoni. Hospital Universitari Germans Trias I Pujol, Badalona (Barcelona), Spain.
+ Lupon, Josep. Hospital Universitari Germans Trias I Pujol, Badalona (Barcelona), Spain.
+ de Boer, Rudolf A. University Medical Centre Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
+ Yoshihisa, Akiomi. Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
+ Takeishi, Yasuchika. Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
+ Egstrup, Michael. Department of Cardiology, Bispebjerg University Hospital, Kobenhavn, Denmark.
+ Gustafsson, Ida. Department of Cardiology, Bispebjerg University Hospital, Kobenhavn, Denmark.
+ Gaggin, Hanna K. Massachusetts General Hospital and Baim Institute for Clinical Research, Boston, USA.
+ Eggers, Kai M. Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
+ Huber, Kurt. Faculty of Internal Medicine, Wilhelminenspital and Sigmund Freud University Medical School, Vienna, Austria.
+ Tentzeris, Ioannis. Faculty of Internal Medicine, Wilhelminenspital and Sigmund Freud University Medical School, Vienna, Austria.
+ Ripoli, Andrea. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Passino, Claudio. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
+ Passino, Claudio. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Sanders-van Wijk, Sandra. Department of Cardiology, Maastricht University Medical Centre, PO Box 5800, 6202AZ, Maastricht, The Netherlands.
+ Emdin, Michele. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
+ Emdin, Michele. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Brunner-La Rocca, Hans-Peter. Department of Cardiology, Maastricht University Medical Centre, PO Box 5800, 6202AZ, Maastricht, The Netherlands. hp.brunnerlarocca@mumc.nl.
+MeSH Subject Headings
+ Age Factors
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Comorbidity
+ *Heart Failure
+ Humans
+ Natriuretic Peptide, Brain/bl [Blood]
+ *Obesity/co [Complications]
+ Peptide Fragments/bl [Blood]
+ Prognosis
+ Stroke Volume
+ Troponin/bl [Blood]
+Keyword Heading
+ Biomarkers
+ Body mass index
+ Co-morbidities
+ Disease severity
+ Heart failure
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Higher body mass index (BMI) is associated with better outcome compared with normal weight in patients with HF and other chronic diseases. It remains uncertain whether the apparent protective role of obesity relates to the absence of comorbidities. Therefore, we investigated the effect of BMI on outcome in younger patients without co-morbidities as compared to older patients with co-morbidities in a large heart failure (HF) population.
+
+ METHODS: In an individual patient data analysis from pooled cohorts, 5,819 patients with chronic HF and data available on BMI, co-morbidities and outcome were analysed. Patients were divided into four groups based on BMI (i.e. <= 18.5 kg/m2, 18.5-25.0 kg/m2; 25.0-30.0 kg/m2; 30.0 kg/m2). Primary endpoints included all-cause mortality and HF hospitalization-free survival.
+
+ RESULTS: Mean age was 65 +/- 12 years, with a majority of males (78%), ischaemic HF and HF with reduced ejection fraction. Frequency of all-cause mortality or HF hospitalization was significantly worse in the lowest two BMI groups as compared to the other two groups; however, this effect was only seen in patients older than 75 years or having at least one relevant co-morbidity, and not in younger patients with HF only. After including medications and N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin concentrations into the model, the prognostic impact of BMI was largely absent even in the elderly group with co-morbidity.
+
+ CONCLUSIONS: The present study suggests that obesity is a marker of less advanced disease, but does not have an independent protective effect in patients with chronic HF. Categories of BMI are only predictive of poor outcome in patients aged > 75 years or with at least one co-morbidity (bottom), but not in those aged < 75 years without co-morbidities (top). The prognostic effect largely disappears in multivariable analyses even for the former group. These findings question the protective effect of obesity in chronic heart failure (HF). Copyright © 2021. The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (Troponin). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Meta-Analysis.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs00392-021-01822-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Marcks&issn=1861-0684&title=Clinical+Research+in+Cardiology&atitle=Re-appraisal+of+the+obesity+paradox+in+heart+failure%3A+a+meta-analysis+of+individual+data.&volume=110&issue=8&spage=1280&epage=1291&date=2021&doi=10.1007%2Fs00392-021-01822-1&pmid=33704552&sid=OVID:medline
+
+<943>
+Unique Identifier
+ 33674695
+Title
+ Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome.
+Source
+ Scientific Reports. 11(1):5320, 2021 03 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moin ASM; Sathyapalan T; Diboun I; Elrayess MA; Butler AE; Atkin SL
+Authors Full Name
+ Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Diboun, Ilhame; Elrayess, Mohamed A; Butler, Alexandra E; Atkin, Stephen L.
+Institution
+ Moin, Abu Saleh Md. Diabetes Research Center (DRC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar.
+ Sathyapalan, Thozhukat. Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Hull, UK.
+ Diboun, Ilhame. Hamad Bin Khalifa University (HBKU), Doha, Qatar.
+ Elrayess, Mohamed A. Biomedical Research Center (BRC), Qatar University, Doha, Qatar.
+ Butler, Alexandra E. Diabetes Research Center (DRC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar. aeb91011@gmail.com.
+ Atkin, Stephen L. Royal College of Surgeons in Ireland Bahrain, Adliya, Kingdom of Bahrain.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Female
+ Humans
+ Inflammation/me [Metabolism]
+ Insulin Resistance
+ *Obesity/me [Metabolism]
+ *Polycystic Ovary Syndrome/me [Metabolism]
+ Risk Factors
+ Young Adult
+Abstract
+ Polycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma coagulation pathway protein levels in PCOS (n = 146) and control (n = 97) women recruited to a PCOS biobank. Circulating levels of a panel of 18 clotting pathway proteins were determined by Slow Off-rate Modified Aptamer-scan plasma protein measurement. Cohorts were age matched, though PCOS had elevated body mass index (p < 0.001), insulin (p < 0.001) and C-reactive protein (CRP) (p < 0.0001). Eight pro-coagulation proteins were elevated in PCOS: plasminogen activator inhibitor-1 (p < 0.0001), fibrinogen (p < 0.01), fibrinogen gamma chain (p < 0.0001), fibronectin (p < 0.01), von Willebrand factor (p < 0.05), D-dimer (p < 0.0001), P-selectin (p < 0.05), and plasma kallikrein (p < 0.001). However, two anticoagulant proteins, vitamin K-dependent protein-S (p < 0.0001) and heparin cofactor-II (p < 0.001) were elevated and prothrombin was decreased (p < 0.05). CRP, as a marker of inflammation, and insulin resistance (HOMA-IR) correlated with 11 and 6 of the clotting proteins, respectively (p < 0.05). When matched for BMI < 25 (16 PCOS, 53 controls) HOMA-IR remained elevated (p < 0.05) and heparin cofactor-II was increased (p < 0.05). In a multivariate analysis accounting for inflammation, insulin resistance and BMI, there was no correlation of PCOS with any of the coagulation proteins. The hypercoagulable state in PCOS is not intrinsic to the disease as it can be fully accounted for by BMI, inflammation and insulin resistance.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-84586-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moin&issn=2045-2322&title=Scientific+Reports&atitle=Metabolic+consequences+of+obesity+on+the+hypercoagulable+state+of+polycystic+ovary+syndrome.&volume=11&issue=1&spage=5320&epage=&date=2021&doi=10.1038%2Fs41598-021-84586-y&pmid=33674695&sid=OVID:medline
+
+<944>
+Unique Identifier
+ 33674561
+Title
+ Hyocholic acid species as novel biomarkers for metabolic disorders.
+Source
+ Nature communications . 12(1):1487, 2021 03 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zheng X; Chen T; Zhao A; Ning Z; Kuang J; Wang S; You Y; Bao Y; Ma X; Yu H; Zhou J; Jiang M; Li M; Wang J; Ma X; Zhou S; Li Y; Ge K; Rajani C; Xie G; Hu C; Guo Y; Lu A; Jia W; Jia W
+Author NameID
+ Guo, Yike; ORCID: https://orcid.org/0000-0002-3075-2161
+ Jia, Weiping; ORCID: https://orcid.org/0000-0002-6244-2168
+ Jia, Wei; ORCID: https://orcid.org/0000-0002-3739-8994
+Authors Full Name
+ Zheng, Xiaojiao; Chen, Tianlu; Zhao, Aihua; Ning, Zhangchi; Kuang, Junliang; Wang, Shouli; You, Yijun; Bao, Yuqian; Ma, Xiaojing; Yu, Haoyong; Zhou, Jian; Jiang, Miao; Li, Mengci; Wang, Jieyi; Ma, Xiaohui; Zhou, Shuiping; Li, Yitao; Ge, Kun; Rajani, Cynthia; Xie, Guoxiang; Hu, Cheng; Guo, Yike; Lu, Aiping; Jia, Weiping; Jia, Wei.
+Institution
+ Zheng, Xiaojiao. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Chen, Tianlu. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Zhao, Aihua. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Ning, Zhangchi. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
+ Ning, Zhangchi. Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
+ Kuang, Junliang. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Wang, Shouli. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ You, Yijun. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Bao, Yuqian. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai, China.
+ Ma, Xiaojing. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai, China.
+ Yu, Haoyong. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai, China.
+ Zhou, Jian. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai, China.
+ Jiang, Miao. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
+ Li, Mengci. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Wang, Jieyi. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Ma, Xiaohui. Department of Pharmacology and Toxicology, Tasly Pharmaceutical Co. Ltd, Tianjin, China.
+ Zhou, Shuiping. Department of Pharmacology and Toxicology, Tasly Pharmaceutical Co. Ltd, Tianjin, China.
+ Li, Yitao. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
+ Ge, Kun. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Rajani, Cynthia. University of Hawaii Cancer Center, Honolulu, HI, USA.
+ Xie, Guoxiang. University of Hawaii Cancer Center, Honolulu, HI, USA.
+ Hu, Cheng. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai, China.
+ Guo, Yike. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
+ Lu, Aiping. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. aipinglu@hkbu.edu.hk.
+ Jia, Weiping. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. wpjia@sjtu.edu.cn.
+ Jia, Weiping. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai, China. wpjia@sjtu.edu.cn.
+ Jia, Wei. Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. weijia1@hkbu.edu.hk.
+ Jia, Wei. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. weijia1@hkbu.edu.hk.
+ Jia, Wei. University of Hawaii Cancer Center, Honolulu, HI, USA. weijia1@hkbu.edu.hk.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Cholic Acids/bl [Blood]
+ *Cholic Acids/ur [Urine]
+ Cohort Studies
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Feces/ch [Chemistry]
+ Female
+ Humans
+ Longitudinal Studies
+ Male
+ *Metabolic Diseases/di [Diagnosis]
+ Middle Aged
+ Obesity/me [Metabolism]
+ Overweight/me [Metabolism]
+ Prediabetic State/di [Diagnosis]
+ Prospective Studies
+Abstract
+ Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict the development of metabolic disorders. We find in the first cohort (n = 1107) that both obesity and diabetes are associated with lower serum concentrations of HCA species. A separate cohort study (n = 91) validates this finding and further reveals that individuals with pre-diabetes are associated with lower levels of HCA species in feces. Serum HCA levels increase in the patients after gastric bypass surgery (n = 38) and can predict the remission of diabetes two years after surgery. The results are replicated in two independent, prospective cohorts (n = 132 and n = 207), where serum HCA species are found to be strong predictors for metabolic disorders in 5 and 10 years, respectively. These findings underscore the association of HCA species with diabetes, and demonstrate the feasibility of using HCA profiles to assess the future risk of developing metabolic abnormalities.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholic Acids). 39016-49-4 (muricholic acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41467-021-21744-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zheng&issn=2041-1723&title=Nature+communications+&atitle=Hyocholic+acid+species+as+novel+biomarkers+for+metabolic+disorders.&volume=12&issue=1&spage=1487&epage=&date=2021&doi=10.1038%2Fs41467-021-21744-w&pmid=33674561&sid=OVID:medline
+
+<945>
+Unique Identifier
+ 33669862
+Title
+ Deciphering Biochemical and Molecular Signatures Associated with Obesity in Context of Metabolic Health.
+Source
+ Genes (Basel). 12(2), 2021 02 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Masih D; Tripathi JK; Rakhra G; Vats A; Verma SK; Jha PK; Sharma M; Ashraf MZ; Singh SN
+Author NameID
+ Masih, Daisy; ORCID: https://orcid.org/0000-0003-4242-3610
+ Tripathi, Jitendra Kumar; ORCID: https://orcid.org/0000-0001-9246-8388
+Authors Full Name
+ Masih, Daisy; Tripathi, Jitendra Kumar; Rakhra, Gurseen; Vats, Annu; Verma, Saroj Kumar; Jha, Prabhash Kumar; Sharma, Manish; Ashraf, Mohammad Zahid; Singh, Som Nath.
+Institution
+ Masih, Daisy. Nutrition Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+ Tripathi, Jitendra Kumar. Nutrition Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+ Rakhra, Gurseen. Nutrition Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+ Vats, Annu. Nutrition Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+ Verma, Saroj Kumar. Nutrition Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+ Jha, Prabhash Kumar. Genomics Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+ Sharma, Manish. Proteomics Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+ Ashraf, Mohammad Zahid. Genomics Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+ Singh, Som Nath. Nutrition Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi 110054, India.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ C-Reactive Protein/ge [Genetics]
+ Female
+ Gene Expression Regulation
+ Genetic Association Studies
+ *Genetic Predisposition to Disease
+ *Glucose-6-Phosphatase/ge [Genetics]
+ Humans
+ *Insulin Resistance/ge [Genetics]
+ Interferon-beta/ge [Genetics]
+ Male
+ *Metabolic Syndrome/ge [Genetics]
+ Metabolic Syndrome/pa [Pathology]
+ *Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ Overweight/ge [Genetics]
+ Overweight/pa [Pathology]
+ Phenotype
+ Risk Assessment
+ Risk Factors
+ Signal Transduction/ge [Genetics]
+Keyword Heading
+ metabolic syndrome
+ metabolically healthy obesity
+ metabolically unhealthy normal weight
+ obesity
+ prevalence
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study aims to identify the clinical and genetic markers related to the two uncommon nutritional statuses-metabolically unhealthy normal-weight (MUNW) and metabolically healthy overweight/obese (MHOW) individuals in the physically active individuals. Physically active male volunteers (n = 120) were recruited, and plasma samples were analyzed for the clinical parameters. Triglycerides, HDL-Cholesterol, LDL-cholesterol, total cholesterol, C-reactive protein, and insulin resistance were considered as markers of metabolic syndrome. The subjects were classified as 'healthy' (0 metabolic abnormalities) or 'unhealthy' (>=1 metabolic abnormalities) in their respective BMI group with a cut-off at 24.9 kg/m2. Analysis of biochemical variables was done using enzyme linked immunosorbent assay (ELISA) kits with further confirmation using western blot analysis. The microarray was conducted, followed by quantitative real-time PCR to identify and analyze differentially expressed genes (DEGs). The MHOW group constituted 12.6%, while the MUNW group constituted 32.4% of the total study population. Pro-inflammatory markers like interleukin-6, tumor necrosis factor (TNF)-alpha, and ferritin were increased in metabolically unhealthy groups in comparison to metabolically healthy groups. Gene expression profiling of MUNW and MHOW individuals resulted in differential expression of 7470 and 5864 genes, respectively. The gene ontology (GO) biological pathway analysis showed significant enrichment of the 'JAK/STAT signaling pathway' in MUNW and 'The information-processing pathway at the IFN-beta enhancer' pathway in MHOW. The G6PC3 gene has genetically emerged as a new distinct gene showing its involvement in insulin resistance. Biochemical, as well as genetic analysis, revealed that MUNW and MHOW are the transition state between healthy and obese individuals with simply having fewer metabolic abnormalities. Moreover, it is possible that the state of obesity is a biological adaptation to cope up with the unhealthy parameters.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 77238-31-4 (Interferon-beta). 9007-41-4 (C-Reactive Protein). EC 3-1-3-9 (Glucose-6-Phosphatase). EC 3-1-3-9 (G6PC3 protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fgenes12020290
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Masih&issn=2073-4425&title=Genes+%28Basel%29&atitle=Deciphering+Biochemical+and+Molecular+Signatures+Associated+with+Obesity+in+Context+of+Metabolic+Health.&volume=12&issue=2&spage=&epage=&date=2021&doi=10.3390%2Fgenes12020290&pmid=33669862&sid=OVID:medline
+
+<946>
+Unique Identifier
+ 33669222
+Title
+ Evaluation of Browning Agents on the White Adipogenesis of Bone Marrow Mesenchymal Stromal Cells: A Contribution to Fighting Obesity.
+Source
+ Cells. 10(2), 2021 02 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Di Maio G; Alessio N; Demirsoy IH; Peluso G; Perrotta S; Monda M; Di Bernardo G
+Author NameID
+ Alessio, Nicola; ORCID: https://orcid.org/0000-0002-5019-2130
+ Demirsoy, Ibrahim Halil; ORCID: https://orcid.org/0000-0001-7825-7787
+ Perrotta, Silverio; ORCID: https://orcid.org/0000-0001-6149-6845
+ Monda, Marcellino; ORCID: https://orcid.org/0000-0002-7184-218X
+ Di Bernardo, Giovanni; ORCID: https://orcid.org/0000-0002-4985-4029
+Authors Full Name
+ Di Maio, Girolamo; Alessio, Nicola; Demirsoy, Ibrahim Halil; Peluso, Gianfranco; Perrotta, Silverio; Monda, Marcellino; Di Bernardo, Giovanni.
+Institution
+ Di Maio, Girolamo. Human Physiology and Unit of Dietetic and Sports Medicine Section, Department of Experimental Medicine, School of Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
+ Alessio, Nicola. Department of Experimental Medicine, Biotechnology and Molecular Biology Section, School of Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
+ Demirsoy, Ibrahim Halil. Department of Experimental Medicine, Biotechnology and Molecular Biology Section, School of Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
+ Peluso, Gianfranco. Institute Bioscience and BioResources, CNR, 80131 Naples, Italy.
+ Perrotta, Silverio. Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, School of Medicine, Universita degli Studi della Campania Luigi Vanvitelli, 80131 Naples, Italy.
+ Monda, Marcellino. Human Physiology and Unit of Dietetic and Sports Medicine Section, Department of Experimental Medicine, School of Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
+ Di Bernardo, Giovanni. Department of Experimental Medicine, Biotechnology and Molecular Biology Section, School of Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
+MeSH Subject Headings
+ Adipogenesis/ge [Genetics]
+ *Adipogenesis
+ *Adipose Tissue, White/pa [Pathology]
+ Apoptosis
+ Biomarkers/me [Metabolism]
+ Cell Proliferation
+ Cellular Senescence
+ Gene Expression Regulation
+ Humans
+ Lipid Droplets/me [Metabolism]
+ *Maillard Reaction
+ *Mesenchymal Stem Cells/cy [Cytology]
+ Mitochondria/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Oxygen Consumption
+ Uncoupling Protein 1/me [Metabolism]
+Keyword Heading
+ BAT
+ WAT
+ adipogenesis
+ browning
+ mesenchymal stromal cells
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Brown-like adipocytes can be induced in white fat depots by a different environmental or drug stimuli, known as "browning" or "beiging". These brite adipocytes express thermogenin UCP1 protein and show different metabolic advantages, such as the ability to acquire a thermogenic phenotype corresponding to standard brown adipocytes that counteracts obesity. In this research, we evaluated the effects of several browning agents during white adipocyte differentiation of bone marrow-derived mesenchymal stromal cells (MSCs). Our in vitro findings identified two compounds that may warrant further in vivo investigation as possible anti-obesity drugs. We found that rosiglitazone and sildenafil are the most promising drug candidates for a browning treatment of obesity. These drugs are already available on the market for treating diabetes and erectile dysfunction, respectively. Thus, their off-label use may be contemplated, but it must be emphasized that some severe side effects are associated with use of these drugs.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Uncoupling Protein 1).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fcells10020403
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Di+Maio&issn=2073-4409&title=Cells&atitle=Evaluation+of+Browning+Agents+on+the+White+Adipogenesis+of+Bone+Marrow+Mesenchymal+Stromal+Cells%3A+A+Contribution+to+Fighting+Obesity.&volume=10&issue=2&spage=&epage=&date=2021&doi=10.3390%2Fcells10020403&pmid=33669222&sid=OVID:medline
+
+<947>
+Unique Identifier
+ 33666098
+Title
+ Interaction of Obesity and Hypertension on Cardiac Metabolic Remodeling and Survival Following Myocardial Infarction.
+Source
+ Journal of the American Heart Association. 10(6):e018212, 2021 03 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mouton AJ; Flynn ER; Moak SP; Li X; da Silva AA; Wang Z; do Carmo JM; Hall ME; Hall JE
+Authors Full Name
+ Mouton, Alan J; Flynn, Elizabeth R; Moak, Sydney P; Li, Xuan; da Silva, Alexandre A; Wang, Zhen; do Carmo, Jussara M; Hall, Michael E; Hall, John E.
+Institution
+ Mouton, Alan J. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ Mouton, Alan J. Mississippi Center for Obesity Research University of Mississippi Medical Center Jackson MS.
+ Flynn, Elizabeth R. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ Moak, Sydney P. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ Li, Xuan. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ Li, Xuan. Mississippi Center for Obesity Research University of Mississippi Medical Center Jackson MS.
+ da Silva, Alexandre A. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ da Silva, Alexandre A. Mississippi Center for Obesity Research University of Mississippi Medical Center Jackson MS.
+ Wang, Zhen. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ Wang, Zhen. Mississippi Center for Obesity Research University of Mississippi Medical Center Jackson MS.
+ do Carmo, Jussara M. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ do Carmo, Jussara M. Mississippi Center for Obesity Research University of Mississippi Medical Center Jackson MS.
+ Hall, Michael E. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ Hall, Michael E. Department of Medicine University of Mississippi Medical Center Jackson MS.
+ Hall, Michael E. Mississippi Center for Obesity Research University of Mississippi Medical Center Jackson MS.
+ Hall, John E. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS.
+ Hall, John E. Mississippi Center for Obesity Research University of Mississippi Medical Center Jackson MS.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ *Collagen/me [Metabolism]
+ Disease Models, Animal
+ Echocardiography
+ Female
+ Heart Ventricles/dg [Diagnostic Imaging]
+ Heart Ventricles/me [Metabolism]
+ *Heart Ventricles/pp [Physiopathology]
+ *Hypertension/co [Complications]
+ Hypertension/me [Metabolism]
+ Hypertension/pp [Physiopathology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ *Myocardial Infarction/et [Etiology]
+ Myocardial Infarction/me [Metabolism]
+ Myocardial Infarction/pp [Physiopathology]
+ *Myocardium/me [Metabolism]
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ *Ventricular Remodeling/ph [Physiology]
+Keyword Heading
+ angiotensin II
+ cardiac hypertrophy
+ heart failure
+ metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Obesity and hypertension are risk factors for myocardial infarction (MI); however, their potential interactions on post-MI outcomes are unclear. We examined interactions of obesity and hypertensionon post-MI function, remodeling, metabolic changes, and recovery. Methods and Results Male and female C57BL/6J mice were provided standard chow or high-fat/fructose diet for 8 weeks and then infused with angiotensin II for 2 weeks to induce hypertension. MI was then induced by surgical ligation of the left coronary artery for 7 days. Obesity alone did not cause cardiac injury or exacerbate hypertension-induced cardiac dysfunction. After MI, however, obese-normotensive mice had lower survival rates compared with chow-fed mice (56% versus 89% males; 54% versus 75% females), which were further decreased by hypertension (29% males; and 35% females). Surviving obese-normotensive males displayed less left ventricular dilation and pulmonary congestion compared with chow-fed males after MI; hypertension reversed left ventricular dilation because of high-fat/fructose diet and promoted significant pulmonary congestion compared with chow-fed controls. Obese-normotensive males displayed higher left ventricular alpha-MHC (alpha-myosin heavy chain) protein, phosphorylated Akt (protein kinase B) and AMPK (adenosine-monophosphate activated kinase), PPAR-gamma (peroxisome proliferator activated receptor gamma), and plasma adiponectin levels after MI, indicating favorable contractile and metabolic changes. However, these favorable contractile and metabolic changes were attenuated by hypertension. Obese-hypertensive males also had lower levels of collagen in the infarcted region, indicating decreased ability to promote an adaptive wound healing response to MI. Conclusions Obesity reduces post-MI survival but is associated with improved post-MI cardiac function and metabolism in surviving normotensive mice. When hypertension accompanies obesity, favorable metabolic pathways associated with obesity are attenuated and post-MI cardiac function and remodeling are adversely impacted.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-34-5 (Collagen).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1161%2fJAHA.120.018212
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mouton&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Interaction+of+Obesity+and+Hypertension+on+Cardiac+Metabolic+Remodeling+and+Survival+Following+Myocardial+Infarction.&volume=10&issue=6&spage=e018212&epage=&date=2021&doi=10.1161%2FJAHA.120.018212&pmid=33666098&sid=OVID:medline
+
+<948>
+Unique Identifier
+ 33664877
+Title
+ Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets. [Review]
+Source
+ Theranostics. 11(8):3996-4010, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang C; Li Z; Liu Y; Yuan L
+Authors Full Name
+ Wang, Chen; Li, Zhelong; Liu, Yunnan; Yuan, Lijun.
+Institution
+ Wang, Chen. Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
+ Li, Zhelong. Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
+ Liu, Yunnan. Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
+ Yuan, Lijun. Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
+MeSH Subject Headings
+ *Atherosclerosis/et [Etiology]
+ Atherosclerosis/pp [Physiopathology]
+ Atherosclerosis/th [Therapy]
+ Biomarkers/me [Metabolism]
+ Blood Platelets/ph [Physiology]
+ Diabetes Mellitus/et [Etiology]
+ Drug Carriers
+ Exosomes/ge [Genetics]
+ *Exosomes/ph [Physiology]
+ Humans
+ Lipid Metabolism
+ Macrophages/ph [Physiology]
+ MicroRNAs/ge [Genetics]
+ Models, Cardiovascular
+ Molecular Targeted Therapy
+ Obesity/et [Etiology]
+ Precision Medicine
+ Risk Factors
+Keyword Heading
+ atherosclerosis
+ biomarker
+ exosomes
+ intercellular communication
+ therapy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Exosomes are nanosized lipid vesicles originating from the endosomal system that carry many macromolecules from their parental cells and play important roles in intercellular communication. The functions and underlying mechanisms of exosomes in atherosclerosis have recently been intensively studied. In this review, we briefly introduce exosome biology and then focus on advances in the roles of exosomes in atherosclerosis, specifically exosomal changes associated with atherosclerosis, their cellular origins and potential functional cargos, and their detailed impacts on recipient cells. We also discuss the potential of exosomes as biomarkers and drug carriers for managing atherosclerosis. Copyright © The author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Drug Carriers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.7150%2fthno.56035
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1838-7640&title=Theranostics&atitle=Exosomes+in+atherosclerosis%3A+performers%2C+bystanders%2C+biomarkers%2C+and+therapeutic+targets.&volume=11&issue=8&spage=3996&epage=4010&date=2021&doi=10.7150%2Fthno.56035&pmid=33664877&sid=OVID:medline
+
+<949>
+Unique Identifier
+ 33662430
+Title
+ Sex differences in markers of metabolic syndrome and adipose tissue inflammation in obesity-prone, Osborne-Mendel and obesity-resistant, S5B/Pl rats.
+Source
+ Life Sciences. 273:119290, 2021 May 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Poret JM; Gaudet DA; Braymer HD; Primeaux SD
+Authors Full Name
+ Poret, Jonquil M; Gaudet, Darryl A; Braymer, H Douglas; Primeaux, Stefany D.
+Institution
+ Poret, Jonquil M. Department of Physiology, LSU Health Sciences Center, New Orleans, LA 70112, United States of America.
+ Gaudet, Darryl A. Department of Physiology, LSU Health Sciences Center, New Orleans, LA 70112, United States of America.
+ Braymer, H Douglas. Joint Diabetes, Endocrinology & Metabolism Program, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States of America.
+ Primeaux, Stefany D. Department of Physiology, LSU Health Sciences Center, New Orleans, LA 70112, United States of America; Joint Diabetes, Endocrinology & Metabolism Program, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States of America. Electronic address: sprime@lsuhsc.edu.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pa [Pathology]
+ Animals
+ *Biomarkers/me [Metabolism]
+ Body Weight
+ *Diet, High-Fat/ae [Adverse Effects]
+ Female
+ Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ *Inflammation/pa [Pathology]
+ Leptin/me [Metabolism]
+ Male
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome/pa [Pathology]
+ *Obesity/co [Complications]
+ Rats
+ Sex Factors
+ Weight Gain
+Keyword Heading
+ High fat diet
+ Metabolic syndrome
+ Osborne-Mendel
+ S5B/Pl
+ Sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The current study examined the role of sex differences in the development of risk factors associated with obesity and its comorbidities using models that differ in their susceptibility to develop obesity, obesity-resistant S5B/Pl (S5B) and obesity-prone Osborne-Mendel (OM) rats. Male and female rats were fed a low fat or high fat diet (HFD) and markers of metabolic syndrome (MetSyn) and expression of inflammatory cytokines/chemokines in visceral and subcutaneous adipose depots were measured. We hypothesized that male and female OM and S5B rats would exhibit differential responses to the consumption of HFD and that females, regardless of susceptibility to develop obesity, would display decreased obesity-related risk factors. Results suggested that consumption of HFD increased adiposity and fasting glucose levels in male OM and S5B rats, decreased circulating adiponectin levels in male S5B rats, and increased body weight and triglyceride levels in male OM rats. The consumption of HFD increased body weight and adiposity in female OM rats, not female S5B rats. Overall, female rats did not meet criteria for MetSyn, while male rats consuming HFD met criteria for MetSyn. Visceral and subcutaneous adipose tissue inflammation was higher in male rats. In visceral adipose tissue, HFD consumption differentially altered expression of cytokines in male and female S5B and OM rats. These findings suggest that resistance to obesity in males may be overridden by chronic consumption of HFD and lead to increased risk for development of obesity-related comorbidities, while female rats appear to be protected from the adverse effects of HFD consumption. Copyright © 2021 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.lfs.2021.119290
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Poret&issn=0024-3205&title=Life+Sciences&atitle=Sex+differences+in+markers+of+metabolic+syndrome+and+adipose+tissue+inflammation+in+obesity-prone%2C+Osborne-Mendel+and+obesity-resistant%2C+S5B%2FPl+rats.&volume=273&issue=&spage=119290&epage=&date=2021&doi=10.1016%2Fj.lfs.2021.119290&pmid=33662430&sid=OVID:medline
+
+<950>
+Unique Identifier
+ 33652785
+Title
+ Navy Bean Supplementation in Established High-Fat Diet-Induced Obesity Attenuates the Severity of the Obese Inflammatory Phenotype.
+Source
+ Nutrients. 13(3), 2021 Feb 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Monk JM; Wu W; Lepp D; Pauls KP; Robinson LE; Power KA
+Author NameID
+ Power, Krista A; ORCID: https://orcid.org/0000-0002-7575-3918
+Authors Full Name
+ Monk, Jennifer M; Wu, Wenqing; Lepp, Dion; Pauls, K Peter; Robinson, Lindsay E; Power, Krista A.
+Institution
+ Monk, Jennifer M. Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
+ Wu, Wenqing. Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada.
+ Lepp, Dion. Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada.
+ Pauls, K Peter. Department of Plant Agriculture, University of Guelph, Guelph, ON N1G 2W1, Canada.
+ Robinson, Lindsay E. Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
+ Power, Krista A. Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
+ Power, Krista A. Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada.
+ Power, Krista A. School of Nutrition Sciences, University of Ottawa, Ottawa, ON K1H 8L1, Canada.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat/mt [Methods]
+ *Diet, Reducing/mt [Methods]
+ *Dietary Supplements
+ Feces/mi [Microbiology]
+ Gastrointestinal Microbiome
+ Inflammation
+ Intestinal Mucosa/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ *Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ *Phaseolus
+ Phenotype
+ Powders
+ Severity of Illness Index
+Keyword Heading
+ adipose tissue inflammation
+ caloric restriction
+ epithelial barrier
+ intestinal health
+ navy beans
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cooked common beans (Phaseolus vulgaris) improve intestinal health in lean mice and attenuate intestinal dysbiosis and inflammation when consumed concurrent with obesity development. We determined the effects of a high-fat (HF) bean supplemented diet in mice with established obesity (induced by 12 weeks of HF diet (60% fat as kcal)) compared to obese mice consuming a HF or low-fat (LF) weight loss control diet. Obese C57BL/6 male mice remained consuming HF for eight weeks or were randomly switched from HF to an isocaloric HF with 15.7% cooked navy bean powder diet (HFaHFB) or LF (11% fat as kcal; HFaLF) (n = 12/group). HFaHFB improved the obese phenotype, including (i) fecal microbiome (increased Prevotella, Akkermansia muciniphila, and short-chain fatty acid levels), (ii) intestinal health (increased ZO-1, claudin-2, Muc2, Relmbeta, and Reg3gamma expression), and (iii) reduced adipose tissue (AT) inflammatory proteins (NFkappaBp65, STAT3, IL-6, MCP-1, and MIP-1alpha), versus HF (p < 0.05). Conversely, HFaLF reduced body weight and circulating hormones (leptin, resistin, and PAI-1) versus HF and HFaHFB (p < 0.05); however, AT inflammation and intestinal health markers were not improved to the same degree as HFaHFB (p < 0.05). Despite remaining on a HF obesogenic diet, introducing beans in established obesity improved the obese phenotype (intestinal health and adipose inflammation) more substantially than weight loss alone.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Powders).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fnu13030757
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Monk&issn=2072-6643&title=Nutrients&atitle=Navy+Bean+Supplementation+in+Established+High-Fat+Diet-Induced+Obesity+Attenuates+the+Severity+of+the+Obese+Inflammatory+Phenotype.&volume=13&issue=3&spage=&epage=&date=2021&doi=10.3390%2Fnu13030757&pmid=33652785&sid=OVID:medline
+
+<951>
+Unique Identifier
+ 33648476
+Title
+ Circulating inflammatory markers may mediate the relationship between low carbohydrate diet and circadian rhythm in overweight and obese women.
+Source
+ BMC Women's Health. 21(1):87, 2021 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tavakoli A; Mirzababaei A; Sajadi F; Mirzaei K
+Authors Full Name
+ Tavakoli, Atefeh; Mirzababaei, Atieh; Sajadi, Forough; Mirzaei, Khadijeh.
+Institution
+ Tavakoli, Atefeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box 14155-6117, Tehran, Iran.
+ Mirzababaei, Atieh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box 14155-6117, Tehran, Iran.
+ Sajadi, Forough. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box 14155-6117, Tehran, Iran.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box 14155-6117, Tehran, Iran. mirzaei_kh@tums.ac.ir.
+MeSH Subject Headings
+ Biomarkers
+ *Circadian Rhythm
+ Diet, Carbohydrate-Restricted
+ Female
+ Humans
+ Obesity/co [Complications]
+ *Overweight
+Keyword Heading
+ Circadian rhythm
+ Inflammation
+ Low carbohydrate diet
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Low carbohydrate diet (LCD) can improve inflammation and obesity and also circadian rhythm disorders can lead to increased inflammation in obese individuals. The purpose of this study is to evaluate the association between adherence of LCD and circadian rhythm mediated by inflammatory markers including transforming growth factor-beta (TGF-beta), interleukin-1beta (IL-1beta) and Galectin-3 in overweight and obese women.
+
+ METHODS: 304 women affected by overweight and obesity were enrolled. We evaluated LCD scores by Semi-quantitative food frequency questionnaire (FFQ) of 147 items. The morning-evening questionnaire (MEQ) was applied to evaluate the circadian rhythm. Biochemical parameters such as inflammatory markers and anthropometric components were assessed.
+
+ RESULTS: There was a negative significant correlation between adherence of LCD and circadian rhythm status. In other words, as the LCD scores increased, the odds of circadian rhythm disturbance in intermediate group and morning type persons decreased compared to evening type. It was showed that, IL-1beta and Galectin-3 in intermediate and morning type groups, destroyed the significance of this relationship and may be considered as mediating markers.
+
+ CONCLUSION: Adherence of LCD can improve the circadian rhythm by reducing levels of inflammatory markers and may be considered as a treatment for obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1186%2fs12905-021-01240-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tavakoli&issn=1472-6874&title=BMC+Women%27s+Health&atitle=Circulating+inflammatory+markers+may+mediate+the+relationship+between+low+carbohydrate+diet+and+circadian+rhythm+in+overweight+and+obese+women.&volume=21&issue=1&spage=87&epage=&date=2021&doi=10.1186%2Fs12905-021-01240-5&pmid=33648476&sid=OVID:medline
+
+<952>
+Unique Identifier
+ 33645254
+Title
+ Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women.
+Source
+ American Journal of Physiology - Endocrinology & Metabolism. 320(5):E864-E873, 2021 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mercer KE; Maurer A; Pack LM; Ono-Moore K; Spray BJ; Campbell C; Chandler CJ; Burnett D; Souza E; Casazza G; Keim N; Newman J; Hunter G; Fernadez J; Garvey WT; Harper ME; Hoppel C; Adams SH; Thyfault J
+Authors Full Name
+ Mercer, Kelly E; Maurer, Adrianna; Pack, Lindsay M; Ono-Moore, Kikumi; Spray, Beverly J; Campbell, Caitlin; Chandler, Carol J; Burnett, Dustin; Souza, Elaine; Casazza, Gretchen; Keim, Nancy; Newman, John; Hunter, Gary; Fernadez, Jose; Garvey, W Timothy; Harper, Mary-Ellen; Hoppel, Charles; Adams, Sean H; Thyfault, John.
+Institution
+ Mercer, Kelly E. Arkansas Children's Nutrition Center, Little Rock, Arkansas.
+ Mercer, Kelly E. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
+ Maurer, Adrianna. Departments of Molecular and Integrative Physiology and Internal Medicine, Kansas Medical Center, Kansas City, Kansas.
+ Pack, Lindsay M. Arkansas Children's Nutrition Center, Little Rock, Arkansas.
+ Ono-Moore, Kikumi. Arkansas Children's Nutrition Center, Little Rock, Arkansas.
+ Spray, Beverly J. Arkansas Children's Research Institute, Little Rock, Arkansas.
+ Campbell, Caitlin. United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center, Davis, California.
+ Chandler, Carol J. United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center, Davis, California.
+ Burnett, Dustin. United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center, Davis, California.
+ Souza, Elaine. United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center, Davis, California.
+ Casazza, Gretchen. Sports Medicine Program, University of California, Davis School of Medicine, Sacramento, California.
+ Keim, Nancy. United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center, Davis, California.
+ Newman, John. United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center, Davis, California.
+ Hunter, Gary. Department of Nutrition Sciences, University of Alabama, Birmingham, Alabama.
+ Fernadez, Jose. Department of Nutrition Sciences, University of Alabama, Birmingham, Alabama.
+ Garvey, W Timothy. Department of Nutrition Sciences, University of Alabama, Birmingham, Alabama.
+ Harper, Mary-Ellen. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario, Canada.
+ Hoppel, Charles. Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio.
+ Adams, Sean H. Department of Surgery, University of California, Davis School of Medicine, Sacramento, California.
+ Adams, Sean H. Center for Alimentary and Metabolic Science, University of California, Davis School of Medicine, Sacramento, California.
+ Thyfault, John. Departments of Molecular and Integrative Physiology and Internal Medicine, Kansas Medical Center, Kansas City, Kansas.
+MeSH Subject Headings
+ Adult
+ Bile Acids and Salts/bi [Biosynthesis]
+ Bile Acids and Salts/bl [Blood]
+ *Bile Acids and Salts/me [Metabolism]
+ *Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ Diet, Reducing
+ *Exercise/ph [Physiology]
+ Exercise Therapy
+ Female
+ Humans
+ Insulin Resistance/ph [Physiology]
+ Liver/me [Metabolism]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ Obesity/th [Therapy]
+ Up-Regulation
+ *Weight Loss/ph [Physiology]
+Keyword Heading
+ exercise
+ female
+ liver
+ metabolism
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Regular exercise has profound metabolic influence on the liver, but effects on bile acid (BA) metabolism are less well known. BAs are synthesized exclusively in the liver from cholesterol via the rate-limiting enzyme cholesterol 7 alpha-hydroxylase (CYP7A1). BAs contribute to the solubilization and absorption of lipids and serve as important signaling molecules, capable of systemic endocrine function. Circulating BAs increase with obesity and insulin resistance, but effects following exercise and diet-induced weight loss are unknown. To test if improvements in fitness and weight loss as a result of exercise training enhance BA metabolism, we measured serum concentrations of total BAs (conjugated and unconjugated primary and secondary BAs) in sedentary, obese, insulin-resistant women (N = 11) before (PRE) and after (POST) a ~14-wk exercise and diet-induced weight loss intervention. BAs were measured in serum collected after an overnight fast and during an oral glucose tolerance test (OGTT). Serum fibroblast growth factor 19 (FGF19; a regulator of BA synthesis) and 7-alpha-hydroxy-cholesten-3-one (C4, a marker of CYP7A1 enzymatic activity) also were measured. Using linear mixed-model analyses and the change in VO2peak (mL/min/kg) as a covariate, we observed that exercise and weight loss intervention decreased total fasting serum BA by ~30% (P = 0.001) and increased fasting serum C4 concentrations by 55% (P = 0.004). C4 was significantly correlated with serum total BAs only in the POST condition, whereas serum FGF19 was unchanged. These data indicate that a fitness and weight loss intervention modifies BA metabolism in obese women and suggest that improved metabolic health associates with higher postabsorptive (fasting) BA synthesis. Furthermore, pre- vs. postintervention patterns of serum C4 following an OGTT support the hypothesis that responsiveness of BA synthesis to postprandial inhibition is improved after exercise and weight loss. NEW & NOTEWORTHY Exercise and weight loss in previously sedentary, insulin-resistant women facilitates a significant improvement in insulin sensitivity and fitness that may be linked to changes in bile acid metabolism. Diet-induced weight loss plus exercise-induced increases in fitness promote greater postabsorptive bile acid synthesis while also sensitizing the bile acid metabolic system to feedback inhibition during a glucose challenge when glucose and insulin are elevated.
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Clinical Trial. Journal Article. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1152%2fajpendo.00644.2020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mercer&issn=0193-1849&title=American+Journal+of+Physiology+-+Endocrinology+%26+Metabolism&atitle=Exercise+training+and+diet-induced+weight+loss+increase+markers+of+hepatic+bile+acid+%28BA%29+synthesis+and+reduce+serum+total+BA+concentrations+in+obese+women.&volume=320&issue=5&spage=E864&epage=E873&date=2021&doi=10.1152%2Fajpendo.00644.2020&pmid=33645254&sid=OVID:medline
+
+<953>
+Unique Identifier
+ 33641803
+Title
+ Changes in metabolic and physiological biomarkers in Mangalarga Marchador horses with induced obesity.
+Source
+ Veterinary Journal. 270:105627, 2021 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ribeiro RM; Ribeiro DS; Cota LO; Leme FO; M Carvalho A; Faleiros RR
+Authors Full Name
+ Ribeiro, Rodrigo M; Ribeiro, Debora S; Cota, Leticia O; Leme, Fabiola O; M Carvalho, Armando; Faleiros, Rafael R.
+Institution
+ Ribeiro, Rodrigo M. Centro Universitario de Mineiros - UNIFIMES, Rua 23, esquina com Av. Caiapos - Setor Aeroporto, Mineiros, GO, Brazil.
+ Ribeiro, Debora S. Centro Universitario de Mineiros - UNIFIMES, Rua 23, esquina com Av. Caiapos - Setor Aeroporto, Mineiros, GO, Brazil.
+ Cota, Leticia O. EQUINOVA Research Group, Veterinary School, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos 6627, campus Pampulha, Belo Horizonte, MG 31270-901, Brazil.
+ Leme, Fabiola O. EQUINOVA Research Group, Veterinary School, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos 6627, campus Pampulha, Belo Horizonte, MG 31270-901, Brazil.
+ M Carvalho, Armando. EQUINOVA Research Group, Veterinary School, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos 6627, campus Pampulha, Belo Horizonte, MG 31270-901, Brazil.
+ Faleiros, Rafael R. EQUINOVA Research Group, Veterinary School, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos 6627, campus Pampulha, Belo Horizonte, MG 31270-901, Brazil; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, CNPq, SHIS, Edificio Santos Dumont, Lago Sul, Brasilia, DF 71605-001, Brazil. Electronic address: faleirosufmg@gmail.com.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/bl [Blood]
+ Cholesterol/bl [Blood]
+ *Diet/ve [Veterinary]
+ *Energy Intake
+ Fructosamine/bl [Blood]
+ *Horse Diseases/bl [Blood]
+ Horse Diseases/et [Etiology]
+ Horses
+ Hypercholesterolemia/et [Etiology]
+ Hypercholesterolemia/ve [Veterinary]
+ Insulin/bl [Blood]
+ Lipids/bl [Blood]
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/ve [Veterinary]
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ *Obesity/ve [Veterinary]
+Keyword Heading
+ Equine
+ Equine metabolic syndrome
+ Hypercaloric diet
+ Hypercholesterolemia
+ Metabolic disorders
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study aimed to characterize and correlate physiological and metabolic changes in horses fed a hypercaloric diet (HD). Nine mature horses with a mean initial body condition score of 2.9 +/- 1 (scale, 1-9) were fed a high-calorie diet for 5 months. Fasting blood samples were collected before the study and biweekly for the duration of the project to determine the concentrations of cholesterol (CHOL), very low (VLDL), low (LDL) and high-density (HDL) lipoproteins, triglycerides, non-esterified fatty acids, and fructosamine. A low-dose oral glucose tolerance test (LGTT) was conducted before, 75 and 150 days after HD introduction. Mean arterial blood pressure was measured monthly. Following HD introduction, CHOL, LDL, HDL, and fructosamine blood concentrations increased (P < 0.001). These four variables were also positively and significantly correlated with the blood insulin response to LGTT. These findings confirm the occurrence of hypercholesterolemia concomitantly with insulin dysregulation development in horses exposed to HD. Copyright © 2021. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 0 (Lipids). 4429-04-3 (Fructosamine). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.tvjl.2021.105627
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ribeiro&issn=1090-0233&title=Veterinary+Journal&atitle=Changes+in+metabolic+and+physiological+biomarkers+in+Mangalarga+Marchador+horses+with+induced+obesity.&volume=270&issue=&spage=105627&epage=&date=2021&doi=10.1016%2Fj.tvjl.2021.105627&pmid=33641803&sid=OVID:medline
+
+<954>
+Unique Identifier
+ 33633339
+Title
+ Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity.
+Source
+ Scientific Reports. 11(1):4652, 2021 02 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang SS; Yang XJ; Ma QH; Xu Y; Chen X; Wang P; Pan CW
+Authors Full Name
+ Zhang, Shan-Shan; Yang, Xue-Jiao; Ma, Qing-Hua; Xu, Yong; Chen, Xing; Wang, Pei; Pan, Chen-Wei.
+Institution
+ Zhang, Shan-Shan. School of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou, 215123, China.
+ Yang, Xue-Jiao. School of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou, 215123, China.
+ Ma, Qing-Hua. The 3rd People's Hospital of Xiangcheng District, Suzhou, 215134, China.
+ Xu, Yong. School of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou, 215123, China.
+ Chen, Xing. Department of Children Health Care, Affiliated Suzhou Hospital of Nanjing Medical University, No.26, Dao Qian Road, Suzhou, 215000, China. cx1708@126.com.
+ Wang, Pei. Department of Health Economics, School of Public Health,, Fudan University, 130 Dong An Road, Shanghai, 200032, China. wang_p@fudan.edu.cn.
+ Wang, Pei. Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China (Fudan University), Shanghai, 200032, China. wang_p@fudan.edu.cn.
+ Pan, Chen-Wei. School of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou, 215123, China. pcwonly@gmail.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ China
+ Humans
+ *Leukocytes/cy [Cytology]
+ *Metabolic Syndrome/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity, Metabolically Benign/bl [Blood]
+ *Overweight/bl [Blood]
+ Risk Factors
+Abstract
+ It remains unclear whether leukocyte-related parameters could be used as biomarkers to differentiate metabolically unhealthy overweight/obesity (MUO) from metabolically healthy overweight/obesity (MHO). We aimed to examine the differences in the distribution of leukocyte-related parameters between older adults with MHO and MUO and the correlations of leukocyte-related parameters with individual components of metabolic abnormality. In the Weitang Geriatric Diseases Study on older Chinese adults aged 60 years or above, 404 individuals with MHO and 480 with MUO contributed to the analysis. Overweight/obesity was defined as body mass index (BMI) of 25 kg/m2 or more. MHO and MUO were discriminated based on the Adult Treatment Panel III (ATP III) criteria. Leukocyte-related parameters were assessed using an automated hematology analyzer. All leukocyte-related parameters except monocytes were elevated in MUO group compared with MHO group (all P < 0.05). The prevalence of MUO increased by 24% with each 109/L increase of leukocytes after adjusting for confounders in the multiple-adjusted model (P < 0.01) and each unit elevation of other parameters except lymphocytes and monocytes were significantly associated with the presence of MUO (all P < 0.01). Trend tests revealed a linear trend for the association between MUO and all the leukocyte-related parameters (all P for trend < 0.05). Significant interactions between leukocyte-related parameters and sex on the presence of MUO were observed (all P value for interaction < 0.05). Higher leukocyte-related parameters were found in patients with MUO than those with MHO and were associated with higher prevalence of MUO which seems to be sex-dependent. Further studies are needed to see whether these parameters could be used as biomarkers for the screening or diagnosis for MUO in clinical or public health practice.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-84367-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=2045-2322&title=Scientific+Reports&atitle=Leukocyte+related+parameters+in+older+adults+with+metabolically+healthy+and+unhealthy+overweight+or+obesity.&volume=11&issue=1&spage=4652&epage=&date=2021&doi=10.1038%2Fs41598-021-84367-7&pmid=33633339&sid=OVID:medline
+
+<955>
+Unique Identifier
+ 33627633
+Title
+ Metabolites and diabetes remission after weight loss.
+Source
+ Nutrition & Diabetes. 11(1):10, 2021 02 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kwee LC; Ilkayeva O; Muehlbauer MJ; Bihlmeyer N; Wolfe B; Purnell JQ; Xavier Pi-Sunyer F; Chen H; Bahnson J; Newgard CB; Shah SH; Laferrere B
+Author NameID
+ Kwee, Lydia Coulter; ORCID: https://orcid.org/0000-0002-6997-8571
+ Laferrere, Blandine; ORCID: https://orcid.org/0000-0001-8255-3175
+Authors Full Name
+ Kwee, Lydia Coulter; Ilkayeva, Olga; Muehlbauer, Michael J; Bihlmeyer, Nathan; Wolfe, Bruce; Purnell, Jonathan Q; Xavier Pi-Sunyer, F; Chen, Haiying; Bahnson, Judy; Newgard, Christopher B; Shah, Svati H; Laferrere, Blandine.
+Institution
+ Kwee, Lydia Coulter. Duke Molecular Physiology Institute, Durham, NC, USA.
+ Ilkayeva, Olga. Duke Molecular Physiology Institute, Durham, NC, USA.
+ Ilkayeva, Olga. Sarah W. Stedman Nutrition and Metabolism Center, Durham, NC, USA.
+ Muehlbauer, Michael J. Duke Molecular Physiology Institute, Durham, NC, USA.
+ Muehlbauer, Michael J. Sarah W. Stedman Nutrition and Metabolism Center, Durham, NC, USA.
+ Bihlmeyer, Nathan. Duke Molecular Physiology Institute, Durham, NC, USA.
+ Wolfe, Bruce. Departments of Surgery and Medicine, Oregon Health & Science University,, Portland, OR, USA.
+ Purnell, Jonathan Q. Departments of Surgery and Medicine, Oregon Health & Science University,, Portland, OR, USA.
+ Xavier Pi-Sunyer, F. New York Obesity Research Center, Division of Endocrinology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
+ Chen, Haiying. Department of Biostatistics and Data Science, Wake Forest School of Medicine Medical Center, Winston-Salem, NC, USA.
+ Bahnson, Judy. Department of Biostatistics and Data Science, Wake Forest School of Medicine Medical Center, Winston-Salem, NC, USA.
+ Newgard, Christopher B. Duke Molecular Physiology Institute, Durham, NC, USA.
+ Newgard, Christopher B. Sarah W. Stedman Nutrition and Metabolism Center, Durham, NC, USA.
+ Newgard, Christopher B. Department of Pharmacology & Cancer Biology and Division of Endocrinology, Department of Medicine, Duke University, Durham, DC, USA.
+ Shah, Svati H. Duke Molecular Physiology Institute, Durham, NC, USA.
+ Shah, Svati H. Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, DC, USA.
+ Laferrere, Blandine. New York Obesity Research Center, Division of Endocrinology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. BBL14@columbia.edu.
+MeSH Subject Headings
+ Amino Acids, Branched-Chain/bl [Blood]
+ Bariatric Surgery/mt [Methods]
+ Betaine/bl [Blood]
+ Biomarkers/bl [Blood]
+ Choline/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Female
+ Humans
+ Male
+ Mass Spectrometry/mt [Methods]
+ Methylamines/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/su [Surgery]
+ Obesity, Morbid/bl [Blood]
+ Obesity, Morbid/su [Surgery]
+ Remission Induction
+ Treatment Outcome
+ Tyrosine/bl [Blood]
+ *Weight Loss
+Abstract
+ There is marked heterogeneity in the response to weight loss interventions with regards to weight loss amount and metabolic improvement. We sought to identify biomarkers predictive of type 2 diabetes remission and amount of weight loss in individuals with severe obesity enrolled in the Longitudinal Assessment of Bariatric Surgery (LABS) and the Look AHEAD (Action for Health in Diabetes) studies. Targeted mass spectrometry-based profiling of 135 metabolites was performed in pre-intervention blood samples using a nested design for diabetes remission over five years (n = 93 LABS, n = 80 Look AHEAD; n = 87 remitters), and for extremes of weight loss at five years (n = 151 LABS; n = 75 with high weight loss). Principal components analysis (PCA) was used for dimensionality reduction, with PCA-derived metabolite factors tested for association with both diabetes remission and weight loss. Metabolic markers were tested for incremental improvement to clinical models, including the DiaRem score. Two metabolite factors were associated with diabetes remission: one primarily composed of branched chain amino acids (BCAA) and tyrosine (odds ratio (95% confidence interval) [OR (95% CI)] = 1.4 [1.0-1.9], p = 0.045), and one with betaine and choline (OR [95% CI] = 0.7 [0.5-0.9], p = 0.02). These results were not significant after adjustment for multiple tests. Inclusion of these two factors in clinical models yielded modest improvements in model fit and performance: in a constructed clinical model, the C-statistic improved from 0.87 to 0.90 (p = 0.02), while the net reclassification index showed improvement in prediction compared to the DiaRem score (NRI = 0.26, p = 0.0013). No metabolite factors associated with weight loss at five years. Baseline levels of metabolites in the BCAA and trimethylamine-N-oxide (TMAO)-microbiome-related pathways are independently and incrementally associated with sustained diabetes remission after weight loss interventions in individuals with severe obesity. These metabolites could serve as clinically useful biomarkers to identify individuals who will benefit the most from weight loss interventions.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers). 0 (Methylamines). 3SCV180C9W (Betaine). 42HK56048U (Tyrosine). FLD0K1SJ1A (trimethyloxamine). N91BDP6H0X (Choline).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41387-021-00151-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kwee&issn=2044-4052&title=Nutrition+%26+Diabetes&atitle=Metabolites+and+diabetes+remission+after+weight+loss.&volume=11&issue=1&spage=10&epage=&date=2021&doi=10.1038%2Fs41387-021-00151-6&pmid=33627633&sid=OVID:medline
+
+<956>
+Unique Identifier
+ 33621881
+Title
+ Subgroup analysis of the relationship between polycyclic aromatic hydrocarbons and rheumatoid arthritis: Data from the National Health and Nutrition Examination Survey, 2003-2014.
+Source
+ Science of the Total Environment. 775:145841, 2021 Jun 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li J; Li X; Xia Y; Fan H; Fan D; Xi X; Ye Q; Zhu Y; Xiao C
+Authors Full Name
+ Li, Jiang; Li, Xiaoya; Xia, Ya; Fan, HuiZhen; Fan, Danping; Xi, Xiaoyu; Ye, Qinbin; Zhu, Yiyong; Xiao, Cheng.
+Institution
+ Li, Jiang. Department of Laboratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
+ Li, Xiaoya. The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100193, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.
+ Xia, Ya. Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
+ Fan, HuiZhen. Department of Gastroenterology, People's Hospital of Yichun, Jiangxi Yichun 336000, China.
+ Fan, Danping. Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China.
+ Xi, Xiaoyu. Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
+ Ye, Qinbin. Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
+ Zhu, Yiyong. College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.
+ Xiao, Cheng. Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China; Department of Emergency, China Japan Friendship Hospital, Beijing 100029, China. Electronic address: xc2002812@126.com.
+MeSH Subject Headings
+ Arthritis, Rheumatoid/ep [Epidemiology]
+ *Arthritis, Rheumatoid
+ Biomarkers
+ Female
+ Humans
+ Middle Aged
+ Nutrition Surveys
+ Obesity
+ *Polycyclic Aromatic Hydrocarbons
+ Smoking
+Keyword Heading
+ NHANES
+ Polycyclic aromatic hydrocarbons
+ Rheumatoid arthritis
+ Subgroup analysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The present study examined potential effect modifiers between polycyclic aromatic hydrocarbon (PAH) exposure and the development of rheumatoid arthritis (RA) and elucidated the relationship between PAHs and RA in subgroups using data from the National Health and Nutrition Examination Survey (NHANES) (2003-2014). The relatedness between eight PAH metabolites and RA in the whole population and different subgroups was tested using multivariable logistic regression analyses. This study included 6297 participants, including 400 RA patients and 5897 non-RA control participants, with full data. Compared to the lowest quartiles, risk of RA was increased in population with the highest quartiles of 1-hydroxynaphthalene (1-NAP), 2-NAP, 2-hydroxyfluorene (2-FLU), and 3-FLU in a bias factor corrected model. The associations between urinary PAH metabolites and RA were prominent in female, young and middle-aged, obese, smoking and alcohol-consuming populations in the subgroup analysis. Our results demonstrated that PAH exposure was related to RA, and the relationship between urinary PAH metabolites and RA differed between subgroups and depended on specific PAH metabolites. Copyright © 2021 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Polycyclic Aromatic Hydrocarbons).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.scitotenv.2021.145841
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=0048-9697&title=Science+of+the+Total+Environment&atitle=Subgroup+analysis+of+the+relationship+between+polycyclic+aromatic+hydrocarbons+and+rheumatoid+arthritis%3A+Data+from+the+National+Health+and+Nutrition+Examination+Survey%2C+2003-2014.&volume=775&issue=&spage=145841&epage=&date=2021&doi=10.1016%2Fj.scitotenv.2021.145841&pmid=33621881&sid=OVID:medline
+
+<957>
+Unique Identifier
+ 33618922
+Title
+ Acute and long-term effects of saxagliptin on post-prandial glycemic response in obese patients with impaired glucose tolerance.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(4):1257-1266, 2021 04 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rezki A; Fysekidis M; Chiheb S; Vicaut E; Cosson E; Valensi P
+Authors Full Name
+ Rezki, Amel; Fysekidis, Marinos; Chiheb, Sabrina; Vicaut, Eric; Cosson, Emmanuel; Valensi, Paul.
+Institution
+ Rezki, Amel. Department of Endocrinology, Diabetology, Nutrition, Jean Verdier Hospital, AP-HP, CRNH-IdF, CINFO, Paris Nord University, Sorbonne Paris Cite, Bondy, France; Sorbonne Paris Cite, UMR U1153 Inserm/U1125 Inra/Cnam/Universite Paris 13, Bobigny, France.
+ Fysekidis, Marinos. Department of Endocrinology, Diabetology, Nutrition, Jean Verdier Hospital, AP-HP, CRNH-IdF, CINFO, Paris Nord University, Sorbonne Paris Cite, Bondy, France; Sorbonne Paris Cite, UMR U1153 Inserm/U1125 Inra/Cnam/Universite Paris 13, Bobigny, France.
+ Chiheb, Sabrina. Department of Endocrinology, Diabetology, Nutrition, Jean Verdier Hospital, AP-HP, CRNH-IdF, CINFO, Paris Nord University, Sorbonne Paris Cite, Bondy, France.
+ Vicaut, Eric. Clinical Research Unit, Lariboisiere-St Louis, Fernand Widal Hospital, APHP, Paris, France.
+ Cosson, Emmanuel. Department of Endocrinology, Diabetology, Nutrition, Jean Verdier Hospital, AP-HP, CRNH-IdF, CINFO, Paris Nord University, Sorbonne Paris Cite, Bondy, France; Sorbonne Paris Cite, UMR U1153 Inserm/U1125 Inra/Cnam/Universite Paris 13, Bobigny, France.
+ Valensi, Paul. Department of Endocrinology, Diabetology, Nutrition, Jean Verdier Hospital, AP-HP, CRNH-IdF, CINFO, Paris Nord University, Sorbonne Paris Cite, Bondy, France. Electronic address: paul.valensi@aphp.fr.
+MeSH Subject Headings
+ Adamantane/ae [Adverse Effects]
+ *Adamantane/aa [Analogs & Derivatives]
+ Adamantane/tu [Therapeutic Use]
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ Dipeptides/ae [Adverse Effects]
+ *Dipeptides/tu [Therapeutic Use]
+ Dipeptidyl-Peptidase IV Inhibitors/ae [Adverse Effects]
+ *Dipeptidyl-Peptidase IV Inhibitors/tu [Therapeutic Use]
+ Double-Blind Method
+ Female
+ France
+ Glucose Intolerance/bl [Blood]
+ Glucose Intolerance/di [Diagnosis]
+ *Glucose Intolerance/dt [Drug Therapy]
+ Glucose Intolerance/et [Etiology]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Pilot Projects
+ *Postprandial Period
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ CGMS
+ DPP-4 inhibitors
+ Glucose variability
+ Impaired glucose tolerance
+ OGTT
+ Obesity
+ Saxagliptin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Dipeptidyl-peptidase inhibitors might be useful in type 2 diabetes prevention. ACCES (ACute and Chronic Effects of Saxagliptin) was a randomized, placebo-controlled, double-blind, controlled phase 2, pilot study aiming to examine in obese patients with impaired glucose tolerance (IGT) the acute effects and the effects after 12 weeks of treatment by saxagliptin on glucose levels at fasting and postprandially after a standard breakfast, and on glucose tolerance.
+
+ METHODS AND RESULTS: We included 24 obese patients with IGT. Patients were randomized to receive saxagliptin 5 mg or placebo in the morning. The treatment was taken on Visit 1 before breakfast, then continued for 12 weeks. Biochemical measurements were performed before, one, two and three hours after a standard breakfast including 75 g of carbohydrates, during Visit 1 and Visit 2 (12 weeks). Glucose variability (GV) was evaluated at Visit 1 from 24-h continuous glucose monitoring including the breakfast. A second OGTT was performed at Visit 3 (3-5 days after Visit 2). Compared with placebo-treated patients, saxagliptin-treated patients had lower 1 h and 2 h post-meal plasma glucose levels at Visit 1 and similar changes at Visit 2 (p < 0.01 to p < 0.004), with lower GV indexes after breakfast at Visit 1. At Visit 3, all patients but one in saxagliptin group and only 4 patients in placebo group turned to normal glucose tolerance. Lower glucose response to breakfast at Visit 1 was predictive of recovery of glucose tolerance.
+
+ CONCLUSION: Saxagliptin has metabolically beneficial effects in glucose-intolerant obese patients by significantly lowering postprandial blood glucose levels.
+
+ CLINICAL TRIAL REGISTRATION NUMBER: NCT01521312: https://clinicaltrials.gov/ct2/show/NCT01521312. Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dipeptides). 0 (Dipeptidyl-Peptidase IV Inhibitors). 9GB927LAJW (saxagliptin). PJY633525U (Adamantane).
+Publication Type
+ Clinical Trial, Phase II. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.numecd.2020.12.025
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rezki&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Acute+and+long-term+effects+of+saxagliptin+on+post-prandial+glycemic+response+in+obese+patients+with+impaired+glucose+tolerance.&volume=31&issue=4&spage=1257&epage=1266&date=2021&doi=10.1016%2Fj.numecd.2020.12.025&pmid=33618922&sid=OVID:medline
+
+<958>
+Unique Identifier
+ 33608628
+Title
+ Caloric restriction, physical exercise, and CB1 receptor blockade as an efficient combined strategy for bodyweight control and cardiometabolic status improvement in male rats.
+Source
+ Scientific Reports. 11(1):4286, 2021 02 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lopez Trinidad LM; Martinez R; Kapravelou G; Galisteo M; Aranda P; Porres JM; Lopez-Jurado M
+Authors Full Name
+ Lopez Trinidad, Luisa M; Martinez, Rosario; Kapravelou, Garyfallia; Galisteo, Milagros; Aranda, Pilar; Porres, Jesus M; Lopez-Jurado, Maria.
+Institution
+ Lopez Trinidad, Luisa M. Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Centre for Biomedical Research, Centre for Research in Sport and Health (IMUDS), Universidad de Granada, Avda. del Conocimiento S/N. Armilla (18100), Granada, Spain.
+ Martinez, Rosario. Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Centre for Biomedical Research, Centre for Research in Sport and Health (IMUDS), Universidad de Granada, Avda. del Conocimiento S/N. Armilla (18100), Granada, Spain.
+ Kapravelou, Garyfallia. Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Centre for Biomedical Research, Centre for Research in Sport and Health (IMUDS), Universidad de Granada, Avda. del Conocimiento S/N. Armilla (18100), Granada, Spain.
+ Galisteo, Milagros. Department of Pharmacology, School of Pharmacy, Biohealth Research Institute, Centre for Biomedical Research, Universidad de Granada, Granada, Spain.
+ Aranda, Pilar. Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Centre for Biomedical Research, Centre for Research in Sport and Health (IMUDS), Universidad de Granada, Avda. del Conocimiento S/N. Armilla (18100), Granada, Spain.
+ Porres, Jesus M. Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Centre for Biomedical Research, Centre for Research in Sport and Health (IMUDS), Universidad de Granada, Avda. del Conocimiento S/N. Armilla (18100), Granada, Spain. jmporres@ugr.es.
+ Lopez-Jurado, Maria. Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Centre for Biomedical Research, Centre for Research in Sport and Health (IMUDS), Universidad de Granada, Avda. del Conocimiento S/N. Armilla (18100), Granada, Spain.
+MeSH Subject Headings
+ Animals
+ Antioxidants/me [Metabolism]
+ Biomarkers/bl [Blood]
+ *Body Weight Maintenance/de [Drug Effects]
+ *Caloric Restriction
+ Cardiovascular Diseases/dt [Drug Therapy]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pp [Physiopathology]
+ *Cardiovascular Physiological Phenomena/de [Drug Effects]
+ Glucose/me [Metabolism]
+ Male
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Physical Conditioning, Animal
+ Rats
+ *Receptor, Cannabinoid, CB1/ai [Antagonists & Inhibitors]
+Abstract
+ Obesity is critically associated with the development of insulin resistance and related cardiovascular and kidney diseases. Several strategies for weight loss have been developed but most of them exhibit a post-intervention rebound effect. Here, we aimed to design combined weight-loss strategies of caloric restriction, physical exercise, and administration of a CB1 receptor blocker to inhibit food intake that also accomplish the objectives of lost-weight maintenance and improvement of cardiovascular and renal function. Diet-induced obesity (DIO) was generated in Sprague Dawley rats for 12 weeks to test the effects of single or combined strategies (i.e. caloric restriction, mixed training protocol, and/or administration of appetite suppressant) on caloric intake, body weight, cardiovascular and renal functionality resulting from a weight-loss intervention period of 3 weeks followed by 6 weeks of weight maintenance. Consumption of a high-fat diet (HFD) caused a significant increase in body weight (5th week of the experimental period) and led to the development of insulin resistance, cardiovascular, and renal alterations. The different interventions tested, resulted in a significant body weight loss and improved glucose metabolism, aerobic capacity, electrocardiographic parameters, vascular expression of adhesion molecules and inflammatory mediators, and renal functionality, reaching values similar to the control normocaloric group or even improving them. Successful maintenance of lost weight was achieved along a 6-week maintenance period in addition to adequate health status. In conclusion, the weight-loss and maintenance intervention strategies tested were efficient at reversing the obesity-related alterations in body weight, glucose metabolism, aerobic capacity, cardiovascular and renal functionality. The beneficial action was very consistent for caloric restriction and physical exercise, whereas administration of a CB1 receptor blocker complemented the effects of the prior interventions in some parameters like body weight or aerobic capacity, and showed specific actions in renal status, increasing glomerular filtration rate and diuresis. Overall, the novelty of our study relies on the easy implementation of combined strategies for effective weight management that resulted in significant health benefits.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Receptor, Cannabinoid, CB1). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-83709-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lopez+Trinidad&issn=2045-2322&title=Scientific+Reports&atitle=Caloric+restriction%2C+physical+exercise%2C+and+CB1+receptor+blockade+as+an+efficient+combined+strategy+for+bodyweight+control+and+cardiometabolic+status+improvement+in+male+rats.&volume=11&issue=1&spage=4286&epage=&date=2021&doi=10.1038%2Fs41598-021-83709-9&pmid=33608628&sid=OVID:medline
+
+<959>
+Unique Identifier
+ 33599536
+Title
+ Neopterin in the Evolution from Obesity to Prediabetes and Newly Diagnosed Type 2 Diabetes.
+Source
+ Metabolic Syndrome & Related Disorders. 19(4):249-255, 2021 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nedeva I; Gateva A; Assyov Y; Karamfilova V; Velikova T; Kamenov Z
+Authors Full Name
+ Nedeva, Iveta; Gateva, Antoaneta; Assyov, Yavor; Karamfilova, Vera; Velikova, Tsvetelina; Kamenov, Zdravko.
+Institution
+ Nedeva, Iveta. Clinic of Endocrinology, Department of Internal Medicine, Medical University of Sofia, University Hospital "Alexandrovska," Sofia, Bulgaria.
+ Gateva, Antoaneta. Clinic of Endocrinology, Department of Internal Medicine, Medical University of Sofia, University Hospital "Alexandrovska," Sofia, Bulgaria.
+ Assyov, Yavor. Clinic of Endocrinology, Department of Internal Medicine, Medical University of Sofia, University Hospital "Alexandrovska," Sofia, Bulgaria.
+ Karamfilova, Vera. Clinic of Endocrinology, Department of Internal Medicine, Medical University of Sofia, University Hospital "Alexandrovska," Sofia, Bulgaria.
+ Velikova, Tsvetelina. Laboratory of Clinical Immunology, Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, University Hospital "Lozenetz," Sofia, Bulgaria.
+ Kamenov, Zdravko. Clinic of Endocrinology, Department of Internal Medicine, Medical University of Sofia, University Hospital "Alexandrovska," Sofia, Bulgaria.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Humans
+ Middle Aged
+ Neopterin/bl [Blood]
+ *Neopterin
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Prediabetic State/bl [Blood]
+ Prediabetic State/ep [Epidemiology]
+ *Prediabetic State
+Keyword Heading
+ carbohydrate disturbances
+ diabetes complications
+ metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Neopterin, marker of cellular immunity and oxidative stress, is mainly produced by activated macrophages. It could play a crucial role in the development of insulin resistance (IR) and type 2 diabetes (T2D). The aim of this study was to investigate the circulating levels of neopterin in different stages of glucose dysregulation from obesity through prediabetes to newly diagnosed diabetes. Methods: Neopterin levels were determined using a commercially available human enzyme-linked immunosorbent assay kit. The homeostasis model assessment of IR was used as an index to assess IR. Results: The sample consisted of 163 subjects with mean age 52.5 +/- 11.3 years, divided in three age- and body mass index (BMI)-matched groups-obesity, prediabetes, and diabetes. The control group consisted of 42 healthy individuals. Neopterin levels were significantly higher in patients with obesity and/or prediabetes and newly diagnosed diabetes than those in the control group, respectively (4.14 +/- 2.51; 4.04 +/- 2.80 and 2.17 +/- 1.93 vs. 0.87 +/- 0.84; P < 0.05). Correlation analysis showed that the level of neopterin positively correlated with BMI, waist, waist-to-stature ratio, waist-to-hip ratio, fasting glucose, and triglycerides. Receiver operating characteristic analysis established neopterin suitable for distinguishing subjects with obesity [area under the curve (AUC) = 0.83; P < 0.001] and carbohydrate disturbances (AUC = 0.59; P < 0.05) from those without these conditions. Neopterin >=0.47 ng/mL have an odds ratio (OR) of 2.71 for development of dysglycemia, whereas threshold value of neopterin >=0.56 ng/mL shows an OR of 5.94 for development of obesity. Conclusion: The levels of neopterin were increased in patients with obesity and carbohydrate disturbances. Further studies will elucidate the role of the biomarker in development of T2D and its complications.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 670-65-5 (Neopterin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1089%2fmet.2020.0144
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nedeva&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Neopterin+in+the+Evolution+from+Obesity+to+Prediabetes+and+Newly+Diagnosed+Type+2+Diabetes.&volume=19&issue=4&spage=249&epage=255&date=2021&doi=10.1089%2Fmet.2020.0144&pmid=33599536&sid=OVID:medline
+
+<960>
+Unique Identifier
+ 33597553
+Title
+ Bone loss markers in the earliest Pacific Islanders.
+Source
+ Scientific Reports. 11(1):3981, 2021 02 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Miszkiewicz JJ; Valentin F; Vrahnas C; Sims NA; Vongsvivut J; Tobin MJ; Clark G
+Author NameID
+ Miszkiewicz, Justyna J; ORCID: https://orcid.org/0000-0002-9769-2706
+Authors Full Name
+ Miszkiewicz, Justyna J; Valentin, Frederique; Vrahnas, Christina; Sims, Natalie A; Vongsvivut, Jitraporn; Tobin, Mark J; Clark, Geoffrey.
+Institution
+ Miszkiewicz, Justyna J. School of Archaeology and Anthropology, Australian National University, 44 Linnaeus Way, Canberra, ACT, 2601, Australia. Justyna.Miszkiewicz@anu.edu.au.
+ Valentin, Frederique. CNRS, UMR 7041, ArScAn, Ethnologie prehistorique, Maison Rene-Ginouves, Archeologie et Ethnologie, 21 Allee de l'Universite, 92023, Nanterre Cedex, France.
+ Valentin, Frederique. Archaeology and Natural History, School of Culture History and Language, College of Asia and the Pacific, Australian National University, Canberra, ACT, 2601, Australia.
+ Vrahnas, Christina. Bone Biology and Disease Unit, St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Melbourne, VIC, 3065, Australia.
+ Vrahnas, Christina. Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Melbourne, VIC, 3065, Australia.
+ Vrahnas, Christina. MRC Protein Phosphorylation and Ubiquitylation Unit, James Black Centre, University of Dundee, Dundee, DD1 5EH, UK.
+ Sims, Natalie A. Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Melbourne, VIC, 3065, Australia.
+ Sims, Natalie A. MRC Protein Phosphorylation and Ubiquitylation Unit, James Black Centre, University of Dundee, Dundee, DD1 5EH, UK.
+ Vongsvivut, Jitraporn. Infrared Microspectroscopy Beamline, ANSTO - Australian Synchrotron, 800 Blackburn Road, Clayton, VIC, 3168, Australia.
+ Tobin, Mark J. Infrared Microspectroscopy Beamline, ANSTO - Australian Synchrotron, 800 Blackburn Road, Clayton, VIC, 3168, Australia.
+ Clark, Geoffrey. Archaeology and Natural History, School of Culture History and Language, College of Asia and the Pacific, Australian National University, Canberra, ACT, 2601, Australia.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ *Biomarkers/an [Analysis]
+ *Bone Density/ph [Physiology]
+ Bone Resorption/me [Metabolism]
+ *Carbonates/an [Analysis]
+ Child
+ Child, Preschool
+ Female
+ *Femur/me [Metabolism]
+ History, Ancient
+ Humans
+ Infant
+ Male
+ Microscopy, Confocal
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Osteoporosis/me [Metabolism]
+ *Phosphates/an [Analysis]
+ Polynesia
+ Spectroscopy, Fourier Transform Infrared
+ Surface Properties
+ Synchrotrons
+Abstract
+ Kingdom of Tonga in Polynesia is one of the most obese nations where metabolic conditions, sedentary lifestyles, and poor quality diet are widespread. These factors can lead to poor musculoskeletal health. However, whether metabolic abnormalities such as osteoporosis occurred in archaeological populations of Tonga is unknown. We employed a microscopic investigation of femur samples to establish whether bone loss afflicted humans in this Pacific region approximately 3000 years ago. Histology, laser confocal microscopy, and synchrotron Fourier-transform infrared microspectroscopy were used to measure bone vascular canal densities, bone porosity, and carbonate and phosphate content of bone composition in eight samples extracted from adult Talasiu males and females dated to 2650 BP. Compared to males, samples from females had fewer vascular canals, lower carbonate and phosphate content, and higher bone porosity. Although both sexes showed evidence of trabecularised cortical bone, it was more widespread in females (35.5%) than males (15.8%). Our data suggest experiences of advanced bone resorption, possibly as a result of osteoporosis. This provides first evidence for microscopic bone loss in a sample of archaeological humans from a Pacific population widely afflicted by metabolic conditions today.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Carbonates). 0 (Phosphates).
+Publication Type
+ Historical Article. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-83264-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Miszkiewicz&issn=2045-2322&title=Scientific+Reports&atitle=Bone+loss+markers+in+the+earliest+Pacific+Islanders.&volume=11&issue=1&spage=3981&epage=&date=2021&doi=10.1038%2Fs41598-021-83264-3&pmid=33597553&sid=OVID:medline
+
+<961>
+Unique Identifier
+ 33596527
+Title
+ Exposure to fine particulate matter promotes platelet activation and thrombosis via obesity-related inflammation.
+Source
+ Journal of Hazardous Materials. 413:125341, 2021 07 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hu D; Jia X; Cui L; Liu J; Chen J; Wang Y; Niu W; Xu J; Miller MR; Loh M; Deng F; Guo X
+Authors Full Name
+ Hu, Dayu; Jia, Xu; Cui, Liyan; Liu, Junxiu; Chen, Jiahui; Wang, Yazheng; Niu, Wei; Xu, Junhui; Miller, Mark R; Loh, Miranda; Deng, Furong; Guo, Xinbiao.
+Institution
+ Hu, Dayu. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Jia, Xu. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Cui, Liyan. Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China.
+ Liu, Junxiu. Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing 100191, China.
+ Chen, Jiahui. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Wang, Yazheng. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Niu, Wei. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Xu, Junhui. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Miller, Mark R. University/BHF Centre for Cardiovascular Science, Queens Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
+ Loh, Miranda. Institute of Occupational Medicine, Research Avenue North Riccarton, Edinburgh EH14 4AP, UK.
+ Deng, Furong. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
+ Guo, Xinbiao. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China. Electronic address: guoxb@bjmu.edu.cn.
+MeSH Subject Headings
+ Adult
+ Air Pollutants/an [Analysis]
+ Air Pollutants/to [Toxicity]
+ *Air Pollutants
+ *Air Pollution
+ Biomarkers
+ Environmental Exposure/an [Analysis]
+ Humans
+ Inflammation/ci [Chemically Induced]
+ Obesity
+ Particulate Matter/an [Analysis]
+ Particulate Matter/to [Toxicity]
+ Platelet Activation
+ *Thrombosis
+Keyword Heading
+ Black carbon
+ Obesity
+ PM(2.5)
+ Platelet
+ Prothrombotic state
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Short-term exposure to fine particulate matter (PM2.5) increases thrombotic risk particularly in obese individuals, but the underlying mechanisms remain unclear. This study aims to compare the effects of PM2.5 on inflammation and platelet activation in obese versus normal-weight adults, and investigate potential causal pathways. We conducted a panel study measuring blood markers in 44 obese and 53 normal-weight adults on 3 separate occasions in 2017-2018. Associations between PM2.5/black carbon (BC) and biomarkers were estimated using mixed-effect models. An interaction analysis compared PM2.5/BC-related effects between subgroups. Biomarker combinations and mediation analysis were performed to elucidate the biological pathways. There was a significant "low-high-low" trend of PM2.5 levels across the 3 study periods. Increases in pro-inflammatory cytokines and changes of platelet activation and aggregation markers were associated with PM2.5/BC in obese subgroup only. Among obese subjects, the combination of pro-inflammatory cytokines and that of platelet markers increased 26.8% (95% CI: 16.0%, 37.9%) and 14.7% (95% CI: 1.9%, 27.0%) per IQR increase in PM2.5 over 5-day and 7-day averages. Inflammation mediated 24.5% of the pathways through which PM2.5 promoted platelet activation. This study suggested obese people are susceptible to pro-thrombotic impacts of PM2.5 exposures. PM2.5 may aggravate thrombosis through obesity-related inflammation. Copyright © 2021 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Air Pollutants). 0 (Biomarkers). 0 (Particulate Matter).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.jhazmat.2021.125341
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hu&issn=0304-3894&title=Journal+of+Hazardous+Materials&atitle=Exposure+to+fine+particulate+matter+promotes+platelet+activation+and+thrombosis+via+obesity-related+inflammation.&volume=413&issue=&spage=125341&epage=&date=2021&doi=10.1016%2Fj.jhazmat.2021.125341&pmid=33596527&sid=OVID:medline
+
+<962>
+Unique Identifier
+ 33594985
+Title
+ Reversion from prediabetes to normoglycaemia after weight change in older persons: The KORA F4/FF4 study.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(2):429-438, 2021 02 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kowall B; Rathmann W; Kuss O; Herder C; Roden M; Stang A; Huth C; Thorand B; Meisinger C; Peters A
+Authors Full Name
+ Kowall, Bernd; Rathmann, Wolfgang; Kuss, Oliver; Herder, Christian; Roden, Michael; Stang, Andreas; Huth, Cornelia; Thorand, Barbara; Meisinger, Christa; Peters, Annette.
+Institution
+ Kowall, Bernd. Center of Clinical Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University Duisburg-Essen, Essen, Germany. Electronic address: bernd.kowall@uk-essen.de.
+ Rathmann, Wolfgang. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; German Center for Diabetes Research (DZD), Munchen, Neuherberg, Germany.
+ Kuss, Oliver. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; German Center for Diabetes Research (DZD), Munchen, Neuherberg, Germany.
+ Herder, Christian. German Center for Diabetes Research (DZD), Munchen, Neuherberg, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany.
+ Roden, Michael. German Center for Diabetes Research (DZD), Munchen, Neuherberg, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany.
+ Stang, Andreas. Center of Clinical Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University Duisburg-Essen, Essen, Germany.
+ Huth, Cornelia. German Center for Diabetes Research (DZD), Munchen, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Thorand, Barbara. German Center for Diabetes Research (DZD), Munchen, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Meisinger, Christa. Chair of Epidemiology, Ludwig-Maximilian-Universitat Munchen, UNIKA-T Augsburg, Augsburg, Germany; Independent Research Group Clinical Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Peters, Annette. German Center for Diabetes Research (DZD), Munchen, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Female
+ Germany/ep [Epidemiology]
+ Glycated Hemoglobin/me [Metabolism]
+ Heart Disease Risk Factors
+ Humans
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity/th [Therapy]
+ Prediabetic State/bl [Blood]
+ Prediabetic State/di [Diagnosis]
+ Prediabetic State/ep [Epidemiology]
+ *Prediabetic State/th [Therapy]
+ Prospective Studies
+ Remission Induction
+ Risk Assessment
+ *Risk Reduction Behavior
+ Time Factors
+ Waist Circumference
+ *Weight Loss
+Keyword Heading
+ Body mass index
+ Cardiovascular risk
+ HbA1c
+ Normal glucose tolerance
+ Prediabetes
+ Waist circumference
+ Weight reduction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: In a non-interventional study of older persons, we assessed the impact of changes in BMI and waist circumference (WC) on reversion from glucose- and HbA1c-defined prediabetes to normoglycaemia (in short: reversion) and on persistence of normoglycaemia. Moreover, we studied whether reversion reduced cardiovascular risk.
+
+ METHODS AND RESULTS: From the population-based KORA S4/F4/FF4 cohort study conducted in Southern Germany, we utilized data from the second and third visit to the study center (median follow-up 6.5 years). We used two overlapping data sets, one with 563 persons with HbA1c<6.5% (mean age 69 years, 51.5% men), one with 510 persons with glucose-based prediabetes or normal glucose tolerance. We calculated proportions of reversion, and estimated adjusted relative risks for the association between initial BMI/WC and change of BMI/WC, respectively, and reversion (and persistence of normoglycaemia, respectively). We estimated 10-year cardiovascular risks using the Framingham 2008 score. Overall, 27.3% of persons with HbA1c-defined prediabetes and 9.2% of persons with glucose-based prediabetes returned to normoglycaemia during follow-up. Lower initial BMI/WC and reduction of BMI/WC were associated with larger probabilities of returning to normoglycaemia (e.g., for HbA1c 5.7-6.4%, RR = 1.24 (95% CI: 1.09-1.41) per 1 kg/m2 decline of BMI). Moreover, reduction of BMI/WC increased probabilities of maintaining normoglycaemia (e.g., for glucose-based prediabetes, RR = 1.09 (1.02-1.16) per 1 kg/m2 decline of BMI). 10-year cardiovascular risk was 5.6 (1.7-9.6) percentage points lower after reversion from glucose-based prediabetes to normoglycaemia.
+
+ CONCLUSION: In older adults, even moderate weight reduction contributes to reversion from prediabetes to normoglycaemia and to maintaining normoglycaemia. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.numecd.2020.09.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kowall&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Reversion+from+prediabetes+to+normoglycaemia+after+weight+change+in+older+persons%3A+The+KORA+F4%2FFF4+study.&volume=31&issue=2&spage=429&epage=438&date=2021&doi=10.1016%2Fj.numecd.2020.09.008&pmid=33594985&sid=OVID:medline
+
+<963>
+Unique Identifier
+ 33586363
+Title
+ Epicardial Adipose Tissue Volume As a Marker of Subclinical Coronary Atherosclerosis in Rheumatoid Arthritis.
+Source
+ Arthritis & Rheumatology. 73(8):1412-1420, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karpouzas GA; Rezaeian P; Ormseth SR; Hollan I; Budoff MJ
+Author NameID
+ Karpouzas, George A; ORCID: https://orcid.org/0000-0003-1065-1563
+Authors Full Name
+ Karpouzas, George A; Rezaeian, Panteha; Ormseth, Sarah R; Hollan, Ivana; Budoff, Matthew J.
+Institution
+ Karpouzas, George A. Harbor-UCLA Medical Center and Lundquist Institute for Biomedical Innovation, Torrance, California.
+ Rezaeian, Panteha. Harbor-UCLA Medical Center and Lundquist Institute for Biomedical Innovation, Torrance, California.
+ Ormseth, Sarah R. Harbor-UCLA Medical Center and Lundquist Institute for Biomedical Innovation, Torrance, California.
+ Hollan, Ivana. Beitostolen Healthsport Center, Beitostolen, Norway, and Norwegian University of Science and Technology, Gjovik, Norway.
+ Budoff, Matthew J. Harbor-UCLA Medical Center and Lundquist Institute for Biomedical Innovation, Torrance, California.
+MeSH Subject Headings
+ Adipose Tissue/dg [Diagnostic Imaging]
+ Adipose Tissue/pa [Pathology]
+ Arthritis, Rheumatoid/co [Complications]
+ *Arthritis, Rheumatoid/pa [Pathology]
+ *Atherosclerosis/dg [Diagnostic Imaging]
+ Atherosclerosis/et [Etiology]
+ Biomarkers/an [Analysis]
+ C-Reactive Protein/an [Analysis]
+ Case-Control Studies
+ Computed Tomography Angiography/mt [Methods]
+ *Computed Tomography Angiography
+ Coronary Angiography/mt [Methods]
+ *Coronary Angiography
+ *Coronary Artery Disease/dg [Diagnostic Imaging]
+ Coronary Artery Disease/et [Etiology]
+ Female
+ Heart Disease Risk Factors
+ Humans
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Pericardium/dg [Diagnostic Imaging]
+ Pericardium/pa [Pathology]
+ Plaque, Atherosclerotic/dg [Diagnostic Imaging]
+ Plaque, Atherosclerotic/et [Etiology]
+ Prednisone/tu [Therapeutic Use]
+ Time Factors
+ Tumor Necrosis Factor Inhibitors/tu [Therapeutic Use]
+Abstract
+ OBJECTIVE: To assess epicardial adipose tissue volume (EATV) and its link to coronary atherosclerosis and plaque morphology in patients with rheumatoid arthritis (RA) and in age- and sex-matched controls.
+
+ METHODS: Computed tomography angiography was used to evaluate EATV and coronary plaque in 139 RA patients and 139 non-RA controls. All models assessing the effect of EATV on plaque were adjusted for age, sex, hypertension, diabetes, dyslipidemia, smoking status, family history of coronary artery disease, and obesity (body mass index of >=30 kg/m2 ). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
+
+ RESULTS: Mean +/- SD log-transformed EATV was similar in patients with RA (4.69 +/- 0.36) and controls (4.70 +/- 0.42). EATV was higher in RA patients with atherosclerosis compared to those without atherosclerosis (P = 0.046). In stratified analyses, EATV was associated with the number of segments with plaque in RA patients (rate ratio 1.20 [95% CI 1.01-1.41] per 1-SD increment of log-unit increase in EATV) but not in controls (P for interaction = 0.089). Likewise, EATV (per 1-SD log-unit increase) was related to the presence of multivessel or obstructive disease (OR 1.63 [95% CI 1.04-2.61]), noncalcified plaque (OR 1.78 [95% CI 1.17-2.70]), and vulnerable plaque (OR 1.77 [95% CI 1.03-3.04]) in RA patients but not in controls (P for interaction <= 0.048 for each). Among RA patients, EATV was associated with the number of segments with plaque in those with RA for <10 years who did not develop any cardiovascular risk factors and who were not obese (P for interaction <= 0.017).
+
+ CONCLUSION: Despite similar EATVs in RA patients and controls, EATVs were associated with greater plaque burden and presence of plaques with a noncalcified component and vulnerability features only in RA patients. EAT may be more pathogenic in RA and play a role in early-stage atherosclerosis. Its value as a biomarker of subclinical atherosclerosis and cardiovascular risk in RA warrants further studies. Copyright © 2021, American College of Rheumatology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Tumor Necrosis Factor Inhibitors). 9007-41-4 (C-Reactive Protein). VB0R961HZT (Prednisone).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1002%2fart.41693
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karpouzas&issn=2326-5191&title=Arthritis+%26+Rheumatology&atitle=Epicardial+Adipose+Tissue+Volume+As+a+Marker+of+Subclinical+Coronary+Atherosclerosis+in+Rheumatoid+Arthritis.&volume=73&issue=8&spage=1412&epage=1420&date=2021&doi=10.1002%2Fart.41693&pmid=33586363&sid=OVID:medline
+
+<964>
+Unique Identifier
+ 33571214
+Title
+ Matrix metalloproteinase 9 a potential major player connecting atherosclerosis and osteoporosis in high fat diet fed rats.
+Source
+ PLoS ONE [Electronic Resource]. 16(2):e0244650, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sabry M; Mostafa S; Rashed L; Abdelgwad M; Kamar S; Estaphan S
+Author NameID
+ Kamar, Samaa; ORCID: https://orcid.org/0000-0002-9040-584X
+ Estaphan, Suzanne; ORCID: https://orcid.org/0000-0003-2369-4052
+Authors Full Name
+ Sabry, Maha; Mostafa, Seham; Rashed, Laila; Abdelgwad, Marwa; Kamar, Samaa; Estaphan, Suzanne.
+Institution
+ Sabry, Maha. Physiology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
+ Mostafa, Seham. Physiology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
+ Rashed, Laila. Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
+ Abdelgwad, Marwa. Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
+ Kamar, Samaa. Histology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
+ Estaphan, Suzanne. Physiology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
+ Estaphan, Suzanne. ANU Medical School, Australian National University, Canberra, ACT, Australia.
+MeSH Subject Headings
+ Alendronate/pd [Pharmacology]
+ Alkaline Phosphatase/me [Metabolism]
+ Animals
+ Atherosclerosis/dt [Drug Therapy]
+ *Atherosclerosis/me [Metabolism]
+ Atherosclerosis/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ Bone Density/de [Drug Effects]
+ Bone Remodeling/de [Drug Effects]
+ Bone Remodeling/ph [Physiology]
+ Carvedilol/pd [Pharmacology]
+ Collagen Type I/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Male
+ *Matrix Metalloproteinase 9/me [Metabolism]
+ Matrix Metalloproteinase 9/ph [Physiology]
+ Obesity/pp [Physiopathology]
+ Osteoporosis/dt [Drug Therapy]
+ *Osteoporosis/me [Metabolism]
+ Osteoporosis/pp [Physiopathology]
+ Peptide Fragments/me [Metabolism]
+ Procollagen/bl [Blood]
+ Rats
+Abstract
+ BACKGROUND: Cardiovascular diseases (CVD) represent one of the major sequelae of obesity. On the other hand, the relationship between bone diseases and obesity remains unclear. An increasing number of biological and epidemiological studies suggest the presence of a link between atherosclerosis and osteoporosis, however, the precise molecular pathways underlying this close association remain poorly understood. The present work thus aimed to study Matrix Metalloproteinase 9 (MMP-9), as a proposed link between atherosclerosis and osteoporosis in high fat diet fed rats.
+
+ METHODS AND FINDINGS: 40 rats were randomly divided into 4 groups: control, untreated atherosclerosis group, atherosclerotic rats treated with carvedilol (10mg/kg/d) and atherosclerotic rats treated with alendronate sodium (10mg/kg/d). After 8 weeks, blood samples were collected for estimation of Lipid profile (Total cholesterol, HDL, TGs), inflammatory markers (IL-6, TNF-alpha, CRP and NO) and Bone turnover markers (BTMs) (Alkaline phosphatase, osteocalcin and pyridinoline). Rats were then euthanized and the aortas and tibias were dissected for histological examination and estimation of MMP-9, N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (CTX) and NF-kB expression. Induction of atherosclerosis via high fat diet and chronic stress induced a significant increase in BTMs, inflammatory markers and resulted in a state of dyslipidaemia. MMP-9 has also shown to be significantly increased in the untreated atherosclerosis rats and showed a significant correlation with all measured parameters. Interestingly, Carvedilol and bisphosphonate had almost equal effects restoring the measured parameters back to normal, partially or completely.
+
+ CONCLUSION: MMP-9 is a pivotal molecule that impact the atherogenic environment of the vessel wall. A strong cross talk exists between MMP-9, cytokine production and macrophage function. It also plays an important regulatory role in osteoclastogenesis. So, it may be a key molecule in charge for coupling CVD and bone diseases in high fat diet fed rats. Therefore, we suggest MMP-9 as a worthy molecule to be targeted pharmacologically in order to control both conditions simultaneously. Further studies are needed to support, to invest and to translate this hypothesis into clinical studies and guidelines.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Collagen Type I). 0 (Peptide Fragments). 0 (Procollagen). 0K47UL67F2 (Carvedilol). EC 3-1-3-1 (Alkaline Phosphatase). EC 3-4-24-35 (Matrix Metalloproteinase 9). EC 3-4-24-35 (Mmp9 protein, rat). X1J18R4W8P (Alendronate).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1371%2fjournal.pone.0244650
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sabry&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Matrix+metalloproteinase+9+a+potential+major+player+connecting+atherosclerosis+and+osteoporosis+in+high+fat+diet+fed+rats.&volume=16&issue=2&spage=e0244650&epage=&date=2021&doi=10.1371%2Fjournal.pone.0244650&pmid=33571214&sid=OVID:medline
+
+<965>
+Unique Identifier
+ 33565691
+Title
+ Effects of liraglutide versus sitagliptin on circulating cardiovascular biomarkers, including circulating progenitor cells, in individuals with type 2 diabetes and obesity: Analyses from the LYDIA trial.
+Source
+ Diabetes, Obesity & Metabolism. 23(6):1409-1414, 2021 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ahmad E; Waller HL; Sargeant JA; Webb MA; Htike ZZ; McCann GP; Gulsin G; Khunti K; Yates T; Henson J; Davies MJ; Webb DR
+Author NameID
+ Ahmad, Ehtasham; ORCID: https://orcid.org/0000-0002-1359-9337
+ Sargeant, Jack A; ORCID: https://orcid.org/0000-0003-0395-7329
+ Khunti, Kamlesh; ORCID: https://orcid.org/0000-0003-2343-7099
+ Davies, Melanie J; ORCID: https://orcid.org/0000-0002-9987-9371
+ Webb, David R; ORCID: https://orcid.org/0000-0002-3932-3339
+Authors Full Name
+ Ahmad, Ehtasham; Waller, Helen L; Sargeant, Jack A; Webb, M'Balu A; Htike, Zin Zin; McCann, Gerry P; Gulsin, Gaurav; Khunti, Kamlesh; Yates, Tom; Henson, Joseph; Davies, Melanie J; Webb, David R.
+Institution
+ Ahmad, Ehtasham. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Ahmad, Ehtasham. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ Waller, Helen L. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Waller, Helen L. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ Sargeant, Jack A. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Sargeant, Jack A. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ Webb, M'Balu A. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Webb, M'Balu A. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ Htike, Zin Zin. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Htike, Zin Zin. Nottingham University Hospitals, Nottingham, UK.
+ McCann, Gerry P. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ McCann, Gerry P. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
+ Gulsin, Gaurav. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ Gulsin, Gaurav. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
+ Khunti, Kamlesh. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Khunti, Kamlesh. NIHR Applied Research Collaborations (ARC) East Midlands, Leicester, UK.
+ Yates, Tom. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Yates, Tom. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ Henson, Joseph. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Henson, Joseph. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ Davies, Melanie J. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Davies, Melanie J. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+ Webb, David R. Diabetes Research Centre, University of Leicester, Leicester, UK.
+ Webb, David R. NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, UK.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 2
+ Dipeptidyl-Peptidase IV Inhibitors/tu [Therapeutic Use]
+ *Dipeptidyl-Peptidase IV Inhibitors
+ Glucagon-Like Peptide 1
+ Humans
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Liraglutide/tu [Therapeutic Use]
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/dt [Drug Therapy]
+ Sitagliptin Phosphate/tu [Therapeutic Use]
+ Stem Cells
+ Vascular Endothelial Growth Factor A
+Keyword Heading
+ liraglutide
+ randomized active-comparator trial
+ sitagliptin
+ stromal cell-derived factor-1-alpha
+ type 2 diabetes
+ vascular endothelial growth factor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The mechanisms behind the beneficial cardiovascular effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) compared with dipeptidyl peptidase-4 inhibitors (DPP4is) remain largely unknown, despite both targeting the incretin pathway to improve glycaemic control. In these prespecified secondary analyses of the LYDIA trial, we examined the impact of the GLP-1RA liraglutide (1.8 mg once-daily) and the DPP4i sitagliptin (100 mg once-daily) on circulating cardiovascular biomarkers associated with atherosclerotic risk, including circulating progenitor cells (CPCs). LYDIA was a 26-week, randomized, active-comparator trial in 61 adults with type 2 diabetes and obesity (mean +/- SD: age 43.8 +/- 6.5 years, body mass index 35.3 +/- 6.4 kg/m2 , HbA1c 7.5% +/- 0.83% [58.5 +/- 9.1 mmol/mol]). Vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1-alpha (SDF-1a), both of which are implicated in endothelial function, were higher at 26 weeks with liraglutide therapy compared with sitagliptin (mean between-group difference [95% CI]: 77.03 [18.29, 135.77] pg/mL, p = .010; and 996.25 [818.85, 1173.64] pg/mL, p < .001, respectively). There were no between-group differences in CPCs, nitric oxide, C-reactive protein, interleukin-6, tumour necrosis factor alpha and advanced glycation end-products. These analyses suggest a favourable impact of liraglutide on VEGF and SDF-1a levels compared with sitagliptin. These factors may therefore be implicated in the differential cardiovascular effects observed between these agents in large cardiovascular outcome trials. However, these are secondary analyses from a previous trial and thus hypothesis-generating. Purposive trials are required to examine these findings further. Copyright © 2021 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dipeptidyl-Peptidase IV Inhibitors). 0 (Hypoglycemic Agents). 0 (Vascular Endothelial Growth Factor A). 839I73S42A (Liraglutide). 89750-14-1 (Glucagon-Like Peptide 1). TS63EW8X6F (Sitagliptin Phosphate).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fdom.14343
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ahmad&issn=1462-8902&title=Diabetes%2C+Obesity+%26+Metabolism&atitle=Effects+of+liraglutide+versus+sitagliptin+on+circulating+cardiovascular+biomarkers%2C+including+circulating+progenitor+cells%2C+in+individuals+with+type+2+diabetes+and+obesity%3A+Analyses+from+the+LYDIA+trial.&volume=23&issue=6&spage=1409&epage=1414&date=2021&doi=10.1111%2Fdom.14343&pmid=33565691&sid=OVID:medline
+
+<966>
+Unique Identifier
+ 33549435
+Title
+ High protein diet leads to prediabetes remission and positive changes in incretins and cardiovascular risk factors.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 31(4):1227-1237, 2021 04 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stentz FB; Mikhael A; Kineish O; Christman J; Sands C
+Authors Full Name
+ Stentz, Frankie B; Mikhael, Andrew; Kineish, Omer; Christman, John; Sands, Chris.
+Institution
+ Stentz, Frankie B. Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: fstentz@uthsc.edu.
+ Mikhael, Andrew. Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Kineish, Omer. Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Christman, John. Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA; FiTelligence, Memphis, TN, USA.
+ Sands, Chris. Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+MeSH Subject Headings
+ Adult
+ Appetite Regulation
+ Biomarkers/bl [Blood]
+ *Diet, High-Protein
+ *Dietary Carbohydrates/ad [Administration & Dosage]
+ Female
+ Gastric Inhibitory Polypeptide/bl [Blood]
+ Ghrelin/bl [Blood]
+ Glucagon-Like Peptide 1/bl [Blood]
+ Heart Disease Risk Factors
+ Humans
+ Hunger
+ *Incretins/bl [Blood]
+ Male
+ Middle Aged
+ Natriuretic Peptide, Brain/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Prediabetic State/bl [Blood]
+ Prediabetic State/di [Diagnosis]
+ *Prediabetic State/dh [Diet Therapy]
+ Prospective Studies
+ Remission Induction
+ Tennessee
+ Time Factors
+ Treatment Outcome
+ Weight Loss
+ Young Adult
+Keyword Heading
+ BNP
+ Cardiovascular risk factors
+ GIP
+ GLP-1
+ High protein diet
+ Incretins
+ Prediabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: High Protein diets may be associated with endocrine responses that favor improved metabolic outcomes. We studied the response to High Protein (HP) versus High Carbohydrate (HC) Diets in terms of incretin hormones GLP-1 and GIP, the hunger hormone ghrelin and BNP, which is associated with cardiac function. We hypothesized that HP diets induce more pronounced release of glucose lowering hormones, suppress hunger and improve cardiac function.
+
+ METHODS AND RESULTS: 24 obese women and men with prediabetes were recruited and randomized to either a High Protein (HP) (n = 12) or High Carbohydrate (HC) (n = 12) diet for 6 months with all food provided. OGTT and MTT were performed and GLP-1, GIP, Ghrelin, BNP, insulin and glucose were measured at baseline and 6 months on the respective diets. Our studies showed that subjects on the HP diet had 100% remission of prediabetes compared to only 33% on the HC diet with similar weight loss. HP diet subjects had a greater increase in (1) OGTT GLP-1 AUC(p = 0.001) and MTT GLP-1 AUC(p = 0.001), (2) OGTT GIP AUC(p = 0.005) and MTT GIP AUC(p = 0.005), and a greater decrease in OGTT ghrelin AUC(p = 0.005) and MTT ghrelin AUC(p = 0.001) and BNP(p = 0.001) compared to the HC diet at 6 months.
+
+ CONCLUSIONS: This study demonstrates that the HP diet increases GLP-1 and GIP which may be responsible in part for improved insulin sensitivity and beta cell function compared to the HC diet. HP ghrelin results demonstrate the HP diet can reduce hunger more effectively than the HC diet. BNP and other CVRF, metabolic parameters and oxidative stress are significantly improved compared to the HC diet. CLINICALTRIALS.
+
+ GOV IDENTIFIER: NCT01642849. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Carbohydrates). 0 (GHRL protein, human). 0 (Ghrelin). 0 (Incretins). 114471-18-0 (Natriuretic Peptide, Brain). 59392-49-3 (Gastric Inhibitory Polypeptide). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Comparative Study. Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.numecd.2020.11.027
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stentz&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=High+protein+diet+leads+to+prediabetes+remission+and+positive+changes+in+incretins+and+cardiovascular+risk+factors.&volume=31&issue=4&spage=1227&epage=1237&date=2021&doi=10.1016%2Fj.numecd.2020.11.027&pmid=33549435&sid=OVID:medline
+
+<967>
+Unique Identifier
+ 33540682
+Title
+ The Impact of Diet and Fibre Fractions on Plasma Adipocytokine Levels in Prediabetic Adults.
+Source
+ Nutrients. 13(2), 2021 Feb 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dodevska MS; Sobajic SS; Dragicevic VD; Stankovic I; Ivanovic ND; Djordjevic BI
+Author NameID
+ Dodevska, Margarita S; ORCID: https://orcid.org/0000-0001-6030-459X
+ Dragicevic, Vesna D; ORCID: https://orcid.org/0000-0003-1905-7931
+ Ivanovic, Nevena Dj; ORCID: https://orcid.org/0000-0001-6620-5007
+Authors Full Name
+ Dodevska, Margarita S; Sobajic, Sladjana S; Dragicevic, Vesna D; Stankovic, Ivan; Ivanovic, Nevena Dj; Djordjevic, Brizita I.
+Institution
+ Dodevska, Margarita S. Institute of Public Health of Serbia "Dr Milan Jovanovic Batut", Center for Hygiene and Human Ecology, Dr Subotica 5, 11000 Belgrade, Serbia.
+ Dodevska, Margarita S. Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
+ Sobajic, Sladjana S. Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
+ Dragicevic, Vesna D. Maize Research Institute, Zemun Polje, S. Bajica 1, 11185 Belgrade, Serbia.
+ Stankovic, Ivan. Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
+ Ivanovic, Nevena Dj. Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
+ Djordjevic, Brizita I. Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adiponectin/bl [Blood]
+ Aged
+ Apelin/bl [Blood]
+ Biomarkers/bl [Blood]
+ *Diet
+ *Dietary Fiber/ad [Administration & Dosage]
+ Exercise
+ Humans
+ Inflammation/bl [Blood]
+ Leptin/bl [Blood]
+ Life Style
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/th [Therapy]
+ *Prediabetic State/bl [Blood]
+ Prediabetic State/th [Therapy]
+ Resistant Starch/ad [Administration & Dosage]
+ Resistin/bl [Blood]
+ Weight Loss
+Keyword Heading
+ adipocytokines
+ fibre fractions
+ lifestyle intervention
+ obese
+ prediabetes
+ resistant starch
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)-rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). The groups differ only in the percentage of the recommended level of the RS consumed as a fraction of the same total fibre amount. The applied dietary intervention includes intake of 7531 KJ/daywith a total fibre portion of 25-35 g/dayfor both groups that includes 15 g/day of RS for the RS group only. The levels of leptin, adiponectin, apelin, resistin, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) are measured, and their relationship to anthropometric and biochemical parameters is estimated. Along with significant body weight loss, only leptin is significantly reduced by 13% in the RS group while in the Fibre group, apelin levels are significant (-21%). Polynomial regression shows a negative correlation between RS intake and adiponectin (R2 = 0.145) and resistin level (R2 = 0.461) in the RS group. This study indicates the possibility that fibre fractions differently influence the outcome of lifestyle interventions, as well as their adipocytokine levels, in obese prediabetic adults.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Apelin). 0 (Biomarkers). 0 (Dietary Fiber). 0 (Leptin). 0 (Resistant Starch). 0 (Resistin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fnu13020487
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dodevska&issn=2072-6643&title=Nutrients&atitle=The+Impact+of+Diet+and+Fibre+Fractions+on+Plasma+Adipocytokine+Levels+in+Prediabetic+Adults.&volume=13&issue=2&spage=&epage=&date=2021&doi=10.3390%2Fnu13020487&pmid=33540682&sid=OVID:medline
+
+<968>
+Unique Identifier
+ 33540559
+Title
+ Peripheral Blood miRome Identified miR-155 as Potential Biomarker of MetS and Cardiometabolic Risk in Obese Patients.
+Source
+ International Journal of Molecular Sciences. 22(3), 2021 Feb 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cerda A; Amaral AA; de Oliveira R; Moraes TI; Braga AA; Graciano-Saldarriaga ME; Fajardo CM; Hirata TDC; Bonezi V; Campos-Salazar AB; Dorea EL; Bernik MMS; Hirata MH; Hirata RDC
+Author NameID
+ Cerda, Alvaro; ORCID: https://orcid.org/0000-0003-3428-8332
+ Hirata, Thiago Dominguez Crespo; ORCID: https://orcid.org/0000-0002-3967-8121
+Authors Full Name
+ Cerda, Alvaro; Amaral, Adonai Aralim; de Oliveira, Raquel; Moraes, Tamiris Invencioni; Braga, Aecio Assuncao; Graciano-Saldarriaga, Magda Elizabeth; Fajardo, Cristina Moreno; Hirata, Thiago Dominguez Crespo; Bonezi, Vivian; Campos-Salazar, Antony Brayan; Dorea, Egidio Lima; Bernik, Marcia Martins Silveira; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo.
+Institution
+ Cerda, Alvaro. Center of Excellence in Translational Medicine, CEMT-BIOREN & Department of Basic Sciences, Universidad de La Frontera, Av. Alemania 0458, Temuco 4810296, Chile.
+ Cerda, Alvaro. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Amaral, Adonai Aralim. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ de Oliveira, Raquel. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Moraes, Tamiris Invencioni. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Braga, Aecio Assuncao. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Graciano-Saldarriaga, Magda Elizabeth. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Fajardo, Cristina Moreno. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Hirata, Thiago Dominguez Crespo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Bonezi, Vivian. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Campos-Salazar, Antony Brayan. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Dorea, Egidio Lima. University Hospital, University of Sao Paulo, Av. Prof. Lineu Prestes 2565, Sao Paulo 05508-000, Brazil.
+ Bernik, Marcia Martins Silveira. University Hospital, University of Sao Paulo, Av. Prof. Lineu Prestes 2565, Sao Paulo 05508-000, Brazil.
+ Hirata, Mario Hiroyuki. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+ Hirata, Rosario Dominguez Crespo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ CCAAT-Enhancer-Binding Protein-beta/bl [Blood]
+ CCAAT-Enhancer-Binding Protein-beta/me [Metabolism]
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ Computer Simulation
+ Female
+ Fibrinogen/an [Analysis]
+ Humans
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ MicroRNAs/bl [Blood]
+ *MicroRNAs/me [Metabolism]
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Proto-Oncogene Mas
+ Receptor, Insulin/me [Metabolism]
+ Risk Factors
+ Sequence Analysis, RNA
+ *Signal Transduction
+Keyword Heading
+ CEBPB
+ cardiometabolic risk
+ metabolic syndrome
+ miR-155
+ microRNAs
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study explored circulating miRNAs and target genes associated with metabolic syndrome (MetS) and cardiometabolic risk in obese patients. Small-RNA sequencing was used to assess the peripheral blood miRNome of 12 obese subjects (6 MetS and 6 non-MetS). Differentially expressed miRNAs and target genes were further analyzed by qPCR in a larger sample of obese patients (48 MetS and 32 non-MetS). miRNA:mRNA interactions were studied using in silico tools. miRNome analysis identified 10 downregulated miRNAs in MetS compared to non-Met patients (p < 0.05). In silico studies revealed three miRNAs (miR-155, miR-181a, and let-7a) and their predictive targets (CCAAT/enhancer-binding protein beta-CEBPB, KRAS proto-oncogene, GTPase-KRAS and suppressor of cytokine signaling 1-SOCS1) with a potential role in the insulin receptor signaling pathway. miR-155 expression was reduced and CEBPB mRNA levels were increased in MetS patients (p < 0.05), and these effects were correlated with the number of MetS diagnostic criteria (p < 0.05). Increased HOMA-IR (>7.6) was associated with low miR-155 levels, high CEBPB expression, and serum hsCRP (p < 0.05). miR-155 was negatively correlated with CEBPB, HOMA-IR, and plasma fibrinogen, and positively correlated with serum adiponectin (p < 0.05). Downregulation of circulating miR-155 is associated with insulin resistance, poor glycemic control, and increased MetS-related cardiometabolic risk, and these effects are potentially mediated by interaction with CEBPB.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (CCAAT-Enhancer-Binding Protein-beta). 0 (CEBPB protein, human). 0 (MAS1 protein, human). 0 (MIRN155 microRNA, human). 0 (MicroRNAs). 0 (Proto-Oncogene Mas). 9001-32-5 (Fibrinogen). EC 2-7-10-1 (Receptor, Insulin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fijms22031468
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cerda&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Peripheral+Blood+miRome+Identified+miR-155+as+Potential+Biomarker+of+MetS+and+Cardiometabolic+Risk+in+Obese+Patients.&volume=22&issue=3&spage=&epage=&date=2021&doi=10.3390%2Fijms22031468&pmid=33540559&sid=OVID:medline
+
+<969>
+Unique Identifier
+ 33536239
+Title
+ Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control.
+Source
+ Life Science Alliance. 4(4), 2021 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Buhler L; Maida A; Vogl ES; Georgiadi A; Takacs A; Kluth O; Schurmann A; Feuchtinger A; von Toerne C; Tsokanos FF; Klepac K; Wolff G; Sakurai M; Ekim Ustunel B; Nawroth P; Herzig S
+Author NameID
+ Nawroth, Peter; ORCID: https://orcid.org/0000-0002-6134-7804
+ Herzig, Stephan; ORCID: https://orcid.org/0000-0003-3950-3652
+Authors Full Name
+ Buhler, Lea; Maida, Adriano; Vogl, Elena Sophie; Georgiadi, Anastasia; Takacs, Andrea; Kluth, Oliver; Schurmann, Annette; Feuchtinger, Annette; von Toerne, Christine; Tsokanos, Foivos-Filippos; Klepac, Katarina; Wolff, Gretchen; Sakurai, Minako; Ekim Ustunel, Bilgen; Nawroth, Peter; Herzig, Stephan.
+Institution
+ Buhler, Lea. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Buhler, Lea. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Buhler, Lea. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Maida, Adriano. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Maida, Adriano. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Maida, Adriano. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Vogl, Elena Sophie. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Vogl, Elena Sophie. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Vogl, Elena Sophie. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Georgiadi, Anastasia. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Georgiadi, Anastasia. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Georgiadi, Anastasia. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Takacs, Andrea. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Takacs, Andrea. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Takacs, Andrea. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Kluth, Oliver. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Kluth, Oliver. Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
+ Schurmann, Annette. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Schurmann, Annette. Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
+ Schurmann, Annette. Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
+ Feuchtinger, Annette. Research Unit Analytical Pathology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ von Toerne, Christine. Research Unit Protein Science, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Tsokanos, Foivos-Filippos. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Tsokanos, Foivos-Filippos. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Tsokanos, Foivos-Filippos. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Klepac, Katarina. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Klepac, Katarina. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Klepac, Katarina. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Wolff, Gretchen. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Wolff, Gretchen. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Wolff, Gretchen. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Sakurai, Minako. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Sakurai, Minako. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Sakurai, Minako. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Ekim Ustunel, Bilgen. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
+ Ekim Ustunel, Bilgen. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Ekim Ustunel, Bilgen. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Nawroth, Peter. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Nawroth, Peter. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Herzig, Stephan. Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany stephan.herzig@helmholtz-muenchen.de.
+ Herzig, Stephan. Joint Heidelberg-IDC Transnational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
+ Herzig, Stephan. Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.
+ Herzig, Stephan. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Energy Metabolism
+ Fluorescent Antibody Technique
+ Gene Expression
+ Gene Knockdown Techniques
+ Glucose/me [Metabolism]
+ *Insulin Secretion
+ Islets of Langerhans/cy [Cytology]
+ Islets of Langerhans/me [Metabolism]
+ Lipid Metabolism
+ Lipocalins/bl [Blood]
+ *Lipocalins/ge [Genetics]
+ *Lipocalins/me [Metabolism]
+ Liver/me [Metabolism]
+ Male
+ Mice
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+Abstract
+ Members of the lipocalin protein family serve as biomarkers for kidney disease and acute phase inflammatory reactions, and are under preclinical development for the diagnosis and therapy of allergies. However, none of the lipocalin family members has made the step into clinical development, mostly due to their complex biological activity and the lack of in-depth mechanistic knowledge. Here, we show that the hepatokine lipocalin 13 (LCN13) triggers glucose-dependent insulin secretion and cell proliferation of primary mouse islets. However, inhibition of endogenous LCN13 expression in lean mice did not alter glucose and lipid homeostasis. Enhanced hepatic secretion of LCN13 in either diet-induced or genetic obesity led to no discernible impact on systemic glucose and lipid metabolism, neither in preventive nor therapeutic setting. Of note, loss or forced LCN13 hepatic secretion did not trigger any compensatory regulation of related lipocalin family members. Together, these data are in stark contrast to the suggested gluco-regulatory and therapeutic role of LCN13 in obesity, and imply complex regulatory steps in LCN13 biology at the organismic level mitigating its principal insulinotropic effects. Copyright © 2021 Buhler et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipocalins). 0 (lipocalin-13 protein, mouse). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.26508%2flsa.202000898
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Buhler&issn=2575-1077&title=Life+Science+Alliance&atitle=Lipocalin+13+enhances+insulin+secretion+but+is+dispensable+for+systemic+metabolic+control.&volume=4&issue=4&spage=&epage=&date=2021&doi=10.26508%2Flsa.202000898&pmid=33536239&sid=OVID:medline
+
+<970>
+Unique Identifier
+ 33535822
+Title
+ DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice.
+Source
+ Diabetes & Vascular Disease Research. 18(1):1479164121990533, 2021 Jan-Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sotokawauchi A; Matsui T; Higashimoto Y; Nishino Y; Koga Y; Yagi M; Yamagishi SI
+Author NameID
+ Sotokawauchi, Ami; ORCID: https://orcid.org/0000-0002-4608-9341
+ Matsui, Takanori; ORCID: https://orcid.org/0000-0001-9506-7571
+ Yamagishi, Sho-Ichi; ORCID: https://orcid.org/0000-0003-0102-0823
+Authors Full Name
+ Sotokawauchi, Ami; Matsui, Takanori; Higashimoto, Yuichiro; Nishino, Yuri; Koga, Yoshinori; Yagi, Minoru; Yamagishi, Sho-Ichi.
+Institution
+ Sotokawauchi, Ami. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.
+ Matsui, Takanori. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.
+ Higashimoto, Yuichiro. Department of Chemistry, Kurume University School of Medicine, Kurume, Japan.
+ Nishino, Yuri. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.
+ Koga, Yoshinori. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.
+ Koga, Yoshinori. Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Japan.
+ Yagi, Minoru. Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Japan.
+ Yamagishi, Sho-Ichi. Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo, Japan.
+MeSH Subject Headings
+ Acetylglucosaminidase/ur [Urine]
+ Animals
+ *Aptamers, Nucleotide/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ Blood Glucose/me [Metabolism]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetic Nephropathies/et [Etiology]
+ Diabetic Nephropathies/me [Metabolism]
+ Diabetic Nephropathies/pa [Pathology]
+ *Diabetic Nephropathies/pc [Prevention & Control]
+ Disease Models, Animal
+ *Glycation End Products, Advanced/me [Metabolism]
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ *Kidney Tubules/de [Drug Effects]
+ Kidney Tubules/me [Metabolism]
+ Kidney Tubules/pa [Pathology]
+ Male
+ Mice
+ Obesity/co [Complications]
+ Oxidative Stress/de [Drug Effects]
+ *Receptor for Advanced Glycation End Products/ai [Antagonists & Inhibitors]
+ Receptor for Advanced Glycation End Products/me [Metabolism]
+ Signal Transduction
+Keyword Heading
+ AGEs
+ Aptamer
+ RAGE
+ diabetic nephropathy
+ tubular injury
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Interaction of advanced glycation end products (AGEs) with the receptor RAGE plays a role in diabetic nephropathy. However, effects of RAGE-aptamer on tubular damage remain unknown. We examined whether RAGE-aptamer inhibited tubular damage in KKAy/Ta mice, obese type 2 diabetic mice with insulin resistance.
+
+ MATERIALS AND METHODS: Male 8-week-old KKAy/Ta mice received continuous intraperitoneal infusion of either control-aptamer or RAGE-aptamer for 8 weeks. Blood biochemistry and blood pressure, and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity and albumin excretion levels were monitored. Kidney and adipose tissue samples were obtained for immunohistochemical analyses.
+
+ RESULTS: Although RAGE-aptamer did not affect blood glucose, blood pressure, body weight, or serum creatinine values, it significantly inhibited the increase in urinary NAG activity and HOMA-IR in diabetic mice at 12 and 16 and at 16 weeks old, respectively. Furthermore, compared with control-aptamer-treated mice, renal carboxymethyllysine, RAGE, and NADPH oxidase-driven superoxide generation were significantly decreased in RAGE-aptamer-treated mice at 12 weeks old with subsequent amelioration of histological alterations in glomerular and interstitial area, while adipose tissue adiponectin expression was increased.
+
+ CONCLUSION: Our present results suggest that RAGE-aptamer could inhibit tubular injury in obese type 2 diabetic mice partly by suppressing the AGE-RAGE-oxidative stress axis and improving insulin resistance.
+Registry Number/Name of Substance
+ 0 (Ager protein, mouse). 0 (Aptamers, Nucleotide). 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycation End Products, Advanced). 0 (Insulin). 0 (Receptor for Advanced Glycation End Products). EC 3-2-1-52 (Acetylglucosaminidase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1177%2f1479164121990533
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sotokawauchi&issn=1479-1641&title=Diabetes+%26+Vascular+Disease+Research&atitle=DNA+aptamer+raised+against+receptor+for+advanced+glycation+end+products+suppresses+renal+tubular+damage+and+improves+insulin+resistance+in+diabetic+mice.&volume=18&issue=1&spage=1479164121990533&epage=&date=2021&doi=10.1177%2F1479164121990533&pmid=33535822&sid=OVID:medline
+
+<971>
+Unique Identifier
+ 33530279
+Title
+ The gap between overweight and obesity status in children - (STROBE-compliant article).
+Source
+ Medicine. 100(4):e24520, 2021 Jan 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Marginean CO; Melit LE; Hutanu A; Ghiga DV; Sasaran MO
+Authors Full Name
+ Marginean, Cristina Oana; Melit, Lorena Elena; Hutanu, Adina; Ghiga, Dana Valentina; Sasaran, Maria Oana.
+Institution
+ Marginean, Cristina Oana. Department of Pediatrics I.
+ Melit, Lorena Elena. Department of Pediatrics I.
+ Hutanu, Adina. Research Laboratory, Center for Advanced Medical and Pharmaceutical Research.
+ Ghiga, Dana Valentina. Department of Medical Informatics and Biostatistics.
+ Sasaran, Maria Oana. Department of Pediatric III, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology from Targu Mures, Gheorghe Marinescu Street No 38, Romania.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Child
+ Cross-Sectional Studies
+ *Disease Progression
+ Female
+ Humans
+ Male
+ *Obesity/bl [Blood]
+ Overweight/bl [Blood]
+ Prospective Studies
+ Puberty/bl [Blood]
+Abstract
+ ABSTRACT: Overweight might represent only the early stage of obesity or it might act as a trigger of self-awareness turning into an ideal chance for preventing further obesity development. The aim of this study was to assess the differences between overweight and obese children in terms of anthropometric, low-grade systemic inflammation, liver impairment and atherosclerotic risk. We performed a study on 132 children aged between 5 and 18 years, divided according to the BMI into 2 groups: group 1 to 76 obese children, and group 2 to 56 overweight children, assessing anthropometric, laboratory and elastography parameters. We obtained significantly higher values of anthropometric parameters in obese children versus overweight ones. We found higher levels of leukocytes, lymphocytes, AST, ALT, and E median (P = .0345, P = .0103, P < .0001, P = .0008 and P < .0001) in the obese group as compared to the overweight one. BMI was positively correlated with neutrophils, NLR, ESR, glycemia, anthropometric parameters, and E median (P = .0007/<.0001/.0018/.0044/<.0001/<.0001/<.0001/<.0001/<.0001/.0204); and negatively with lymphocytes and HDL-cholesterol (r = -0.2747/-0.2181, P = .0116/.0120). Our study underlined significant differences between overweight and obese children in terms of inflammatory status and liver impairment suggesting that the risk is directly related to the increase in BMI. Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1097%2fMD.0000000000024520
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Marginean&issn=0025-7974&title=Medicine&atitle=The+gap+between+overweight+and+obesity+status+in+children+-+%28STROBE-compliant+article%29.&volume=100&issue=4&spage=e24520&epage=&date=2021&doi=10.1097%2FMD.0000000000024520&pmid=33530279&sid=OVID:medline
+
+<972>
+Unique Identifier
+ 33527668
+Title
+ Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface-expression of LDLR and CD36 and NLRP3 inflammasome.
+Source
+ Physiological Reports. 9(3):e14721, 2021 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cyr Y; Lamantia V; Bissonnette S; Burnette M; Besse-Patin A; Demers A; Wabitsch M; Chretien M; Mayer G; Estall JL; Saleh M; Faraj M
+Author NameID
+ Lamantia, Valerie; ORCID: https://orcid.org/0000-0002-4643-6462
+ Bissonnette, Simon; ORCID: https://orcid.org/0000-0001-6612-942X
+ Chretien, Michel; ORCID: https://orcid.org/0000-0002-8588-4460
+ Estall, Jennifer L; ORCID: https://orcid.org/0000-0002-9838-1440
+ Faraj, May; ORCID: https://orcid.org/0000-0002-3473-0031
+Authors Full Name
+ Cyr, Yannick; Lamantia, Valerie; Bissonnette, Simon; Burnette, Melanie; Besse-Patin, Aurele; Demers, Annie; Wabitsch, Martin; Chretien, Michel; Mayer, Gaetan; Estall, Jennifer L; Saleh, Maya; Faraj, May.
+Institution
+ Cyr, Yannick. Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada.
+ Cyr, Yannick. Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada.
+ Cyr, Yannick. Montreal Diabetes Research Center (MDRC), Montreal, QC, Canada.
+ Lamantia, Valerie. Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada.
+ Lamantia, Valerie. Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada.
+ Lamantia, Valerie. Montreal Diabetes Research Center (MDRC), Montreal, QC, Canada.
+ Bissonnette, Simon. Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada.
+ Bissonnette, Simon. Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada.
+ Bissonnette, Simon. Montreal Diabetes Research Center (MDRC), Montreal, QC, Canada.
+ Burnette, Melanie. Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada.
+ Burnette, Melanie. Montreal Diabetes Research Center (MDRC), Montreal, QC, Canada.
+ Besse-Patin, Aurele. Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada.
+ Besse-Patin, Aurele. Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada.
+ Besse-Patin, Aurele. Montreal Diabetes Research Center (MDRC), Montreal, QC, Canada.
+ Demers, Annie. Institut de cardiologie de Montreal (ICM), Montreal, QC, Canada.
+ Wabitsch, Martin. Department of Pediatrics and Adolescent Medicine, Ulm University Hospital, Ulm, Germany.
+ Chretien, Michel. Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada.
+ Chretien, Michel. Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada.
+ Chretien, Michel. Ottawa Health Research Institute (OHRI), Ottawa, ON, Canada.
+ Mayer, Gaetan. Department of Pediatrics and Adolescent Medicine, Ulm University Hospital, Ulm, Germany.
+ Mayer, Gaetan. Faculty of Pharmacy, Universite de Montreal, Montreal, QC, Canada.
+ Estall, Jennifer L. Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada.
+ Estall, Jennifer L. Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada.
+ Estall, Jennifer L. Montreal Diabetes Research Center (MDRC), Montreal, QC, Canada.
+ Saleh, Maya. Department of Medicine, McGill University, Montreal, QC, Canada.
+ Saleh, Maya. Department of Life Sciences and Health, The University of Bordeaux, Bordeaux, France.
+ Faraj, May. Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada.
+ Faraj, May. Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada.
+ Faraj, May. Montreal Diabetes Research Center (MDRC), Montreal, QC, Canada.
+MeSH Subject Headings
+ Adipocytes, White/im [Immunology]
+ Adipocytes, White/me [Metabolism]
+ Adipogenesis
+ Adipose Tissue, White/im [Immunology]
+ *Adipose Tissue, White/me [Metabolism]
+ Aged
+ Biomarkers/bl [Blood]
+ *CD36 Antigens/me [Metabolism]
+ Cells, Cultured
+ *Cholesterol/bl [Blood]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Down-Regulation
+ Female
+ Humans
+ *Inflammasomes/me [Metabolism]
+ Interleukin-1beta/me [Metabolism]
+ Male
+ Middle Aged
+ *NLR Family, Pyrin Domain-Containing 3 Protein/me [Metabolism]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/en [Enzymology]
+ Obesity/im [Immunology]
+ *Proprotein Convertase 9/bl [Blood]
+ *Receptors, LDL/me [Metabolism]
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ adipose tissue and systemic inflammation
+ apoB-lipoproteins
+ cardiometabolic risk
+ plasma apoB-to-PCSK9
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: LDL-cholesterol lowering variants that upregulate receptor uptake of LDL, such as in PCSK9 and HMGCR, are associated with diabetes via unclear mechanisms. Activation of the NLRP3 inflammasome/interleukin-1 beta (IL-1beta) pathway promotes white adipose tissue (WAT) dysfunction and type 2 diabetes (T2D) and is regulated by LDL receptors (LDLR and CD36). We hypothesized that: (a) normocholesterolemic subjects with lower plasma PCSK9, identifying those with higher WAT surface-expression of LDLR and CD36, have higher activation of WAT NLRP3 inflammasome and T2D risk factors, and; (b) LDL upregulate adipocyte NLRP3 inflammasome and inhibit adipocyte function.
+
+ METHODOLOGY: Post hoc analysis was conducted in 27 overweight/ obese subjects with normal plasma LDL-C and measures of disposition index (DI during Botnia clamps) and postprandial fat metabolism. WAT was assessed for surface-expression of LDLR and CD36 (immunohistochemistry), protein expression (immunoblot), IL-1beta secretion (AlphaLISA), and function (3 H-triolein storage).
+
+ RESULTS: Compared to subjects with higher than median plasma PCSK9, subjects with lower PCSK9 had higher WAT surface-expression of LDLR (+81%) and CD36 (+36%), WAT IL-1beta secretion (+284%), plasma IL-1 receptor-antagonist (+85%), and postprandial hypertriglyceridemia, and lower WAT pro-IL-1beta protein (-66%), WAT function (-62%), and DI (-28%), without group-differences in body composition, energy intake or expenditure. Adjusting for WAT LDLR or CD36 eliminated group-differences in WAT function, DI, and postprandial hypertriglyceridemia. Native LDL inhibited Simpson-Golabi Behmel-syndrome (SGBS) adipocyte differentiation and function and increased inflammation.
+
+ CONCLUSION: Normocholesterolemic subjects with lower plasma PCSK9 and higher WAT surface-expression of LDLR and CD36 have higher WAT NLRP3 inflammasome activation and T2D risk factors. This may be due to LDL-induced inhibition of adipocyte function. Copyright © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CD36 Antigens). 0 (CD36 protein, human). 0 (IL1B protein, human). 0 (Inflammasomes). 0 (Interleukin-1beta). 0 (LDLR protein, human). 0 (NLR Family, Pyrin Domain-Containing 3 Protein). 0 (NLRP3 protein, human). 0 (Receptors, LDL). 97C5T2UQ7J (Cholesterol). EC 3-4-21 (PCSK9 protein, human). EC 3-4-21 (Proprotein Convertase 9).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.14814%2fphy2.14721
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cyr&issn=2051-817X&title=Physiological+Reports&atitle=Lower+plasma+PCSK9+in+normocholesterolemic+subjects+is+associated+with+upregulated+adipose+tissue+surface-expression+of+LDLR+and+CD36+and+NLRP3+inflammasome.&volume=9&issue=3&spage=e14721&epage=&date=2021&doi=10.14814%2Fphy2.14721&pmid=33527668&sid=OVID:medline
+
+<973>
+Unique Identifier
+ 33524144
+Title
+ Ascending Growth is Associated with Offspring Adiposity in Pregnancies Complicated with Obesity or Gestational Diabetes.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 106(5):e1993-e2004, 2021 04 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huvinen E; Tuomaala AK; Bergman PH; Meinila J; Tammelin T; Kulmala J; Engberg E; Koivusalo SB
+Authors Full Name
+ Huvinen, Emilia; Tuomaala, Anna-Kaisa; Bergman, Paula H; Meinila, Jelena; Tammelin, Tuija; Kulmala, Janne; Engberg, Elina; Koivusalo, Saila B.
+Institution
+ Huvinen, Emilia. Teratology Information Service, Emergency Medicine, Department of Prehospital Emergency Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Tuomaala, Anna-Kaisa. Department of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Bergman, Paula H. Biostatistics Consulting, Department of Public Health, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Meinila, Jelena. Department of Food and Nutrition, University of Helsinki, Helsinki, Finland.
+ Tammelin, Tuija. LIKES Research Centre for Physical Activity and Health, Jyvaskyla, Finland.
+ Kulmala, Janne. LIKES Research Centre for Physical Activity and Health, Jyvaskyla, Finland.
+ Engberg, Elina. Folkhalsan Research Center, Helsinki, Finland.
+ Engberg, Elina. Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
+ Koivusalo, Saila B. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+MeSH Subject Headings
+ *Adipose Tissue/pa [Pathology]
+ *Adiposity
+ Adult
+ Biomarkers/an [Analysis]
+ Child, Preschool
+ Diabetes, Gestational/ep [Epidemiology]
+ *Diabetes, Gestational/pp [Physiopathology]
+ Female
+ Finland/ep [Epidemiology]
+ Follow-Up Studies
+ Humans
+ Infant
+ Infant, Newborn
+ *Life Style
+ Male
+ *Obesity/pp [Physiopathology]
+ Pregnancy
+ Prognosis
+ Prospective Studies
+Keyword Heading
+ body composition
+ childhood obesity
+ early growth
+ fetal programming
+ gestational diabetes
+ lifestyle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Early growth is associated with childhood adiposity, but the influence of lifestyle remains unknown.
+
+ OBJECTIVE: This work aimed to investigate the association of growth profiles from high-risk pregnancies with adiposity at age 5 years, taking into account lifestyle and several antenatal/postnatal exposures.
+
+ METHODS: This prospective cohort study.
+
+ INCLUDED: 609 children born during the Finnish Gestational Diabetes Prevention Study (RADIEL), recruiting women with body mass index (BMI) greater than or equal to 30 and/or prior gestational diabetes mellitus (GDM) (2008-2013). Altogether 332 children attended the 5-year follow-up (2014-2017). Main outcome measures included growth profiles based on ponderal index (PI = weight/height3), investigated using latent class mixed models. Adiposity was assessed with anthropometrics and body composition (InBody720).
+
+ RESULTS: We identified 3 growth profiles: ascending (n = 82), intermediate (n = 351), and descending (n = 149). Children with ascending growth had a higher body fat percentage, ISO-BMI, and waist circumference (P < .05) at age 5 years. Ascending (beta 4.09; CI, 1.60-6.58) and intermediate (beta 2.27; CI, 0.50-4.03) profiles were associated with higher fat percentage, even after adjustment for age, sex, gestational age, diet, physical activity, education, and prepregnancy BMI. Similar associations existed with ISO-BMI. After adjusting for age and education, ascending growth was associated with prepregnancy BMI (odds ratio [OR] 1.06; CI, 1.01-1.12), primiparity (OR 3.07; CI, 1.68-5.62), cesarean delivery (OR 2.23; CI, 1.18-4.21), and lifestyle intervention (OR 2.56; CI, 1.44-4.57). However, meeting the intervention goals and exclusive breastfeeding for 3 months or more were associated with lower odds of ascending growth.
+
+ CONCLUSION: Accelerated early growth was associated with higher adiposity in 5-year-old children from high-risk pregnancies, even when adjusted for lifestyle. Reducing cesarean deliveries and promoting breastfeeding may be beneficial for postnatal growth. Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1210%2fclinem%2fdgaa979
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huvinen&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Ascending+Growth+is+Associated+with+Offspring+Adiposity+in+Pregnancies+Complicated+with+Obesity+or+Gestational+Diabetes.&volume=106&issue=5&spage=e1993&epage=e2004&date=2021&doi=10.1210%2Fclinem%2Fdgaa979&pmid=33524144&sid=OVID:medline
+
+<974>
+Unique Identifier
+ 33524007
+Title
+ White adipose tissue-infiltrated CD11b+ myeloid cells are a source of S100A4, a new potential marker of hepatic damage.
+Source
+ European Journal of Endocrinology. 184(4):533-541, 2021 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Reyes M; Gonzalez L; Ibeas K; Cereijo R; Taxeras SD; Pellitero S; Martinez E; Tarasco J; Moreno P; Malagon P; Higueras C; Soria A; Puig-Domingo M; Villarroya F; Serra D; Herrero L; Sanchez-Infantes D
+Author NameID
+ Sanchez-Infantes, David; ORCID: https://orcid.org/0000-0001-6086-7501
+Authors Full Name
+ Reyes, Marjorie; Gonzalez, Lorena; Ibeas, Kevin; Cereijo, Ruben; Taxeras, Siri D; Pellitero, Silvia; Martinez, Eva; Tarasco, Jordi; Moreno, Pau; Malagon, Paloma; Higueras, Carmen; Soria, Andrea; Puig-Domingo, Manel; Villarroya, Francesc; Serra, Dolors; Herrero, Laura; Sanchez-Infantes, David.
+Institution
+ Reyes, Marjorie. Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute.
+ Gonzalez, Lorena. Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute.
+ Ibeas, Kevin. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Cereijo, Ruben. Department of Biochemistry and Molecular Biology, and Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
+ Cereijo, Ruben. Biomedical Research Center (Red Fisiopatologia de la Obesidad y Nutricion) (CIBEROBN), ISCIII, Madrid, Spain.
+ Cereijo, Ruben. Research Institute and Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
+ Taxeras, Siri D. Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute.
+ Pellitero, Silvia. Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute.
+ Pellitero, Silvia. Biomedical Research Center (Red Fisiopatologia de la Diabetes y enfermedades metabolicas) (CIBERDEM), ISCIII, Madrid, Spain.
+ Martinez, Eva. Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute.
+ Tarasco, Jordi. Department of Surgery, Germans Trias i Pujol Research Institute, Barcelona, Spain.
+ Moreno, Pau. Department of Surgery, Germans Trias i Pujol Research Institute, Barcelona, Spain.
+ Malagon, Paloma. Department of plastic Surgery, Germans Trias i Pujol Research Institute, Barcelona, Spain.
+ Higueras, Carmen. Department of plastic Surgery, Germans Trias i Pujol Research Institute, Barcelona, Spain.
+ Soria, Andrea. Department of Surgery, Germans Trias i Pujol Research Institute, Barcelona, Spain.
+ Puig-Domingo, Manel. Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute.
+ Puig-Domingo, Manel. Biomedical Research Center (Red Fisiopatologia de la Diabetes y enfermedades metabolicas) (CIBERDEM), ISCIII, Madrid, Spain.
+ Villarroya, Francesc. Department of Biochemistry and Molecular Biology, and Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
+ Villarroya, Francesc. Biomedical Research Center (Red Fisiopatologia de la Obesidad y Nutricion) (CIBEROBN), ISCIII, Madrid, Spain.
+ Serra, Dolors. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Serra, Dolors. Biomedical Research Center (Red Fisiopatologia de la Obesidad y Nutricion) (CIBEROBN), ISCIII, Madrid, Spain.
+ Herrero, Laura. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Herrero, Laura. Biomedical Research Center (Red Fisiopatologia de la Obesidad y Nutricion) (CIBEROBN), ISCIII, Madrid, Spain.
+ Sanchez-Infantes, David. Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute.
+ Sanchez-Infantes, David. Biomedical Research Center (Red Fisiopatologia de la Obesidad y Nutricion) (CIBEROBN), ISCIII, Madrid, Spain.
+ Sanchez-Infantes, David. Area de Bioquimica y Biologia Molecular, Departamento de Ciencias Basicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avda. de Atenas s/n. Alcorcon, Madrid, Spain.
+MeSH Subject Headings
+ Adipose Tissue, White/ch [Chemistry]
+ Adipose Tissue, White/me [Metabolism]
+ *Adipose Tissue, White/pa [Pathology]
+ Adult
+ Aged
+ Animals
+ Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ *CD11b Antigen/an [Analysis]
+ *Fatty Liver/bl [Blood]
+ Fatty Liver/et [Etiology]
+ Fatty Liver/pa [Pathology]
+ Female
+ Gene Expression
+ Humans
+ Intra-Abdominal Fat/ch [Chemistry]
+ Intra-Abdominal Fat/pa [Pathology]
+ Macrophages/me [Metabolism]
+ Male
+ Mice
+ Middle Aged
+ *Myeloid Cells/ch [Chemistry]
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ RAW 264.7 Cells
+ *S100 Calcium-Binding Protein A4/an [Analysis]
+ S100 Calcium-Binding Protein A4/bl [Blood]
+ S100 Calcium-Binding Protein A4/ge [Genetics]
+ Subcutaneous Fat/ch [Chemistry]
+ Subcutaneous Fat/pa [Pathology]
+Abstract
+ CONTEXT: The endocrine and immunological properties of subcutaneous vs visceral adipose tissue (sWAT and vWAT, respectively) have turned a milestone in the study of metabolic diseases. The cytokine S100A4 is increased in obesity and has a role in adipose tissue dysfunction. However, the cellular source and its potential role in hepatic damage in obesity has not been elucidated.
+
+ OBJECTIVE: We aim to study the regulation of S100A4 in immune cells present in sWAT and vWAT, as well as its potential role as a circulating marker of hepatic inflammation and steatosis.
+
+ DESIGN: A cohort of 60 patients with obesity and distinct metabolic status was analyzed. CD11b+ myeloid cells and T cells were isolated from sWAT and vWAT by magnetic-activating cell sorting, and RNA was obtained. S100A4 gene expression was measured, and correlation analysis with clinical data was performed. Liver biopsies were obtained from 20 patients, and S100A4 circulating levels were measured to check the link with hepatic inflammation and steatosis.
+
+ RESULTS: S100A4 gene expression was strongly upregulated in sWAT- vs vWAT-infiltrated CD11b+ cells, but this modulation was not observed in T cells. S100A4 mRNA levels from sWAT (and not from vWAT) CD11b+ cells positively correlated with glycemia, triglycerides, TNF-alpha gene expression and proliferation markers. Finally, circulating S100A4 directly correlated with liver steatosis and hepatic inflammatory markers.
+
+ CONCLUSION: Our data suggest that sWAT-infiltrated CD11b+ cells could be a major source of S100A4 in obesity. Moreover, our correlations identify circulating S100A4 as a potential novel biomarker of hepatic damage and steatosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CD11b Antigen). 0 (S100 Calcium-Binding Protein A4). 142662-27-9 (S100A4 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1530%2fEJE-20-1130
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Reyes&issn=0804-4643&title=European+Journal+of+Endocrinology&atitle=White+adipose+tissue-infiltrated+CD11b%2B+myeloid+cells+are+a+source+of+S100A4%2C+a+new+potential+marker+of+hepatic+damage.&volume=184&issue=4&spage=533&epage=541&date=2021&doi=10.1530%2FEJE-20-1130&pmid=33524007&sid=OVID:medline
+
+<975>
+Unique Identifier
+ 33507953
+Title
+ Effects of circuit training or a nutritional intervention on body mass index and other cardiometabolic outcomes in children and adolescents with overweight or obesity.
+Source
+ PLoS ONE [Electronic Resource]. 16(1):e0245875, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Seo YG; Lim H; Kim Y; Ju YS; Choi YJ; Lee HJ; Jang HB; Park SI; Park KH
+Author NameID
+ Seo, Young-Gyun; ORCID: https://orcid.org/0000-0001-8294-1741
+ Choi, Yong-Jun; ORCID: https://orcid.org/0000-0002-1622-3175
+ Park, Kyung Hee; ORCID: https://orcid.org/0000-0001-9806-0076
+Authors Full Name
+ Seo, Young-Gyun; Lim, Hyunjung; Kim, YoonMyung; Ju, Young-Su; Choi, Yong-Jun; Lee, Hye-Ja; Jang, Han Byul; Park, Sang Ick; Park, Kyung Hee.
+Institution
+ Seo, Young-Gyun. Department of Family Medicine, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, Republic of Korea.
+ Lim, Hyunjung. Department of Medical Nutrition, Kyung Hee University, Yongin, Gyeonggi-do, Republic of Korea.
+ Kim, YoonMyung. University College, Yonsei University International Campus, Incheon, Republic of Korea.
+ Ju, Young-Su. Department of Occupational and Environmental Medicine, National Medical Center, Seoul, Republic of Korea.
+ Choi, Yong-Jun. Department of Social and Preventive Medicine & Health Services Research Center, Hallym University College of Medicine, Chucheon, Gangwon-do, Republic of Korea.
+ Lee, Hye-Ja. Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Chungbuk, Republic of Korea.
+ Jang, Han Byul. Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Chungbuk, Republic of Korea.
+ Park, Sang Ick. Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Chungbuk, Republic of Korea.
+ Park, Kyung Hee. Department of Family Medicine, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, Republic of Korea.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adolescent
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Child
+ *Diet, Reducing/mt [Methods]
+ *Exercise Therapy/mt [Methods]
+ Female
+ Humans
+ Male
+ Metabolic Syndrome/dh [Diet Therapy]
+ *Metabolic Syndrome/th [Therapy]
+ Obesity/dh [Diet Therapy]
+ *Obesity/th [Therapy]
+Abstract
+ OBJECTIVE: We aimed to assess the effectiveness of the first 6 months of a 24 month multidisciplinary intervention program including circuit training and a balanced diet in children and adolescents with obesity.
+
+ METHODS: A quasi-experimental intervention trial included 242 participants (age [mean+/-standard deviation]: 11.3+/-2.06 years, 97 girls) of at least 85th percentile of age- and sex-specific body mass index (BMI). Participants were grouped into three to receive usual care (usual care group), exercise intervention with circuit training (exercise group), or intensive nutritional and feedback intervention with a balanced diet (nutritional group). Primary outcome was BMI z-score, while secondary outcomes included body composition, cardiometabolic risk markers, nutrition, and physical fitness.
+
+ RESULTS: Among the participants, 80.6% had a BMI >= the 97th percentile for age and sex. The BMI z-score of the overall completers decreased by about 0.080 after 6 months of intervention (p < 0.001). After the intervention, both exercise and nutritional groups had significantly lower BMI z-scores than the baseline data by about 0.14 and 0.075, respectively (p < 0.05). Significant group by time interaction effects were observed between exercise versus usual care group in BMI z-score (beta, -0.11; 95% confidence interval (CI), -0.20 to -0.023) and adiponectin (beta, 1.31; 95% CI, 1.08 to 1.58); and between nutritional versus usual care group in waist circumference (beta, -3.47; 95% CI, -6.06 to -0.89). No statistically significant differences were observed in any of the other secondary outcomes assessed.
+
+ CONCLUSION: Multidisciplinary intervention including circuit training and a balanced diet for children and adolescents with obesity reduced the BMI z-score and improved cardiometabolic risk markers such as adiponectin and waist circumference.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Clinical Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1371%2fjournal.pone.0245875
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Seo&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Effects+of+circuit+training+or+a+nutritional+intervention+on+body+mass+index+and+other+cardiometabolic+outcomes+in+children+and+adolescents+with+overweight+or+obesity.&volume=16&issue=1&spage=e0245875&epage=&date=2021&doi=10.1371%2Fjournal.pone.0245875&pmid=33507953&sid=OVID:medline
+
+<976>
+Unique Identifier
+ 33504891
+Title
+ Obesity is not a risk factor for either mortality or complications after laparoscopic cholecystectomy for cholecystitis.
+Source
+ Scientific Reports. 11(1):2384, 2021 01 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Enami Y; Aoki T; Tomioka K; Hakozaki T; Hirai T; Shibata H; Saito K; Takano Y; Seki J; Oae S; Shimada S; Nakahara K; Takehara Y; Mukai S; Sawada N; Ishida F; Murakami M; Kudo SE
+Authors Full Name
+ Enami, Yuta; Aoki, Takeshi; Tomioka, Kodai; Hakozaki, Tomoki; Hirai, Takahito; Shibata, Hideki; Saito, Kazuhiko; Takano, Yojiro; Seki, Junichi; Oae, Sonoko; Shimada, Shoji; Nakahara, Kenta; Takehara, Yusuke; Mukai, Shumpei; Sawada, Naruhiko; Ishida, Fumio; Murakami, Masahiko; Kudo, Shin-Ei.
+Institution
+ Enami, Yuta. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan. enami@med.showa-u.ac.jp.
+ Enami, Yuta. Department of Gastrointestinal and General Surgery, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. enami@med.showa-u.ac.jp.
+ Aoki, Takeshi. Department of Gastrointestinal and General Surgery, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
+ Tomioka, Kodai. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Tomioka, Kodai. Department of Gastrointestinal and General Surgery, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
+ Hakozaki, Tomoki. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Hakozaki, Tomoki. Department of Gastrointestinal and General Surgery, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
+ Hirai, Takahito. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Hirai, Takahito. Department of Gastrointestinal and General Surgery, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
+ Shibata, Hideki. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Shibata, Hideki. Department of Gastrointestinal and General Surgery, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
+ Saito, Kazuhiko. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Saito, Kazuhiko. Department of Gastrointestinal and General Surgery, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
+ Takano, Yojiro. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Seki, Junichi. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Oae, Sonoko. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Shimada, Shoji. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Nakahara, Kenta. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Takehara, Yusuke. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Mukai, Shumpei. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Sawada, Naruhiko. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Ishida, Fumio. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+ Murakami, Masahiko. Department of Gastrointestinal and General Surgery, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
+ Kudo, Shin-Ei. Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Body Mass Index
+ *Cholecystectomy, Laparoscopic/ae [Adverse Effects]
+ *Cholecystitis/ep [Epidemiology]
+ Cholecystitis/et [Etiology]
+ Cholecystitis/mo [Mortality]
+ Cholecystitis/su [Surgery]
+ Female
+ Humans
+ Male
+ Middle Aged
+ Mortality
+ *Obesity/co [Complications]
+ Odds Ratio
+ *Postoperative Complications/ep [Epidemiology]
+ *Postoperative Complications/et [Etiology]
+ Risk Assessment
+ Risk Factors
+Abstract
+ Obesity is a positive predictor of surgical morbidity. There are few reports of laparoscopic cholecystectomy (LC) outcomes in obese patients. This study aimed to clarify this relationship. This retrospective study included patients who underwent LC at Showa University Northern Yokohama Hospital between January 2017 and April 2020. A total of 563 cases were examined and divided into two groups: obese (n = 142) (BMI >= 25 kg/m2) and non-obese (n = 241) (BMI < 25 kg/m2). The non-obese group had more female patients (54%), whereas the obese group had more male patients (59.1%). The obese group was younger (56.6 years). Preoperative laboratory data of liver function were within the normal range. The obese group had a significantly higher white blood cell (WBC) count (6420/muL), although this was within normal range. Operative time was significantly longer in the obese group (p = 0.0001). However, blood loss and conversion rate were not significantly different among the groups, neither were surgical outcomes, including postoperative hospital stay and complications. Male sex and previous abdominal surgery were risk factors for conversion, and only advanced age (>= 79 years) was an independent predictor of postoperative complications as observed in the multivariate analysis. Although the operation time was prolonged in obese patients, operative factors and outcomes were not. Therefore, LC could be safely performed in obese patients with similar efficacy as in non-obese patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-81963-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Enami&issn=2045-2322&title=Scientific+Reports&atitle=Obesity+is+not+a+risk+factor+for+either+mortality+or+complications+after+laparoscopic+cholecystectomy+for+cholecystitis.&volume=11&issue=1&spage=2384&epage=&date=2021&doi=10.1038%2Fs41598-021-81963-5&pmid=33504891&sid=OVID:medline
+
+<977>
+Unique Identifier
+ 33500513
+Title
+ Atorvastatin impairs liver mitochondrial function in obese Gottingen Minipigs but heart and skeletal muscle are not affected.
+Source
+ Scientific Reports. 11(1):2167, 2021 01 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Christiansen LB; Dohlmann TL; Ludvigsen TP; Parfieniuk E; Ciborowski M; Szczerbinski L; Kretowski A; Desler C; Tiano L; Orlando P; Martinussen T; Olsen LH; Larsen S
+Authors Full Name
+ Christiansen, Liselotte Bruun; Dohlmann, Tine Lovso; Ludvigsen, Trine Pagh; Parfieniuk, Ewa; Ciborowski, Michal; Szczerbinski, Lukasz; Kretowski, Adam; Desler, Claus; Tiano, Luca; Orlando, Patrick; Martinussen, Torben; Olsen, Lisbeth Hoier; Larsen, Steen.
+Institution
+ Christiansen, Liselotte Bruun. The LIFEPHARM Centre, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1870, Frederiksberg, Denmark. lbc@sund.ku.dk.
+ Dohlmann, Tine Lovso. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.
+ Ludvigsen, Trine Pagh. Global Drug Development, Novo Nordisk A/S, Novo Nordisk Park, 2760, Malov, Denmark.
+ Parfieniuk, Ewa. Clinical Research Centre, Medical University of Bialystok, 15-089, Bialystok, Poland.
+ Ciborowski, Michal. Clinical Research Centre, Medical University of Bialystok, 15-089, Bialystok, Poland.
+ Szczerbinski, Lukasz. Clinical Research Centre, Medical University of Bialystok, 15-089, Bialystok, Poland.
+ Kretowski, Adam. Clinical Research Centre, Medical University of Bialystok, 15-089, Bialystok, Poland.
+ Desler, Claus. Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.
+ Tiano, Luca. Department of Life and Environmental Sciences (DISVA), Polytechnic University of Marche, via Brecce Bianche, Ancona, Italy.
+ Orlando, Patrick. Department of Life and Environmental Sciences (DISVA), Polytechnic University of Marche, via Brecce Bianche, Ancona, Italy.
+ Martinussen, Torben. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Oster Farimagsgade 5, 1014, Copenhagen, Denmark.
+ Olsen, Lisbeth Hoier. The LIFEPHARM Centre, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1870, Frederiksberg, Denmark.
+ Larsen, Steen. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark. stelar@sund.ku.dk.
+ Larsen, Steen. Clinical Research Centre, Medical University of Bialystok, 15-089, Bialystok, Poland. stelar@sund.ku.dk.
+MeSH Subject Headings
+ Animals
+ *Atorvastatin/pd [Pharmacology]
+ Biomarkers/me [Metabolism]
+ Cell Respiration
+ Citrate (si)-Synthase/me [Metabolism]
+ Hydrogen Peroxide/me [Metabolism]
+ Male
+ Metabolome
+ Mitochondria, Heart/de [Drug Effects]
+ *Mitochondria, Heart/me [Metabolism]
+ Mitochondria, Liver/de [Drug Effects]
+ Mitochondria, Liver/me [Metabolism]
+ *Mitochondria, Liver/pa [Pathology]
+ Mitochondria, Muscle/de [Drug Effects]
+ *Mitochondria, Muscle/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Oxidation-Reduction
+ Oxidative Stress/de [Drug Effects]
+ Protein Carbonylation/de [Drug Effects]
+ Swine
+ Swine, Miniature
+ Ubiquinone/aa [Analogs & Derivatives]
+ Ubiquinone/me [Metabolism]
+Abstract
+ Statins lower the risk of cardiovascular events but have been associated with mitochondrial functional changes in a tissue-dependent manner. We investigated tissue-specific modifications of mitochondrial function in liver, heart and skeletal muscle mediated by chronic statin therapy in a Gottingen Minipig model. We hypothesized that statins enhance the mitochondrial function in heart but impair skeletal muscle and liver mitochondria. Mitochondrial respiratory capacities, citrate synthase activity, coenzyme Q10 concentrations and protein carbonyl content (PCC) were analyzed in samples of liver, heart and skeletal muscle from three groups of Gottingen Minipigs: a lean control group (CON, n = 6), an obese group (HFD, n = 7) and an obese group treated with atorvastatin for 28 weeks (HFD + ATO, n = 7). Atorvastatin concentrations were analyzed in each of the three tissues and in plasma from the Gottingen Minipigs. In treated minipigs, atorvastatin was detected in the liver and in plasma. A significant reduction in complex I + II-supported mitochondrial respiratory capacity was seen in liver of HFD + ATO compared to HFD (P = 0.022). Opposite directed but insignificant modifications of mitochondrial respiratory capacity were seen in heart versus skeletal muscle in HFD + ATO compared to the HFD group. In heart muscle, the HFD + ATO had significantly higher PCC compared to the HFD group (P = 0.0323). In the HFD group relative to CON, liver mitochondrial respiration decreased whereas in skeletal muscle, respiration increased but these changes were insignificant when normalizing for mitochondrial content. Oral atorvastatin treatment in Gottingen Minipigs is associated with a reduced mitochondrial respiratory capacity in the liver that may be linked to increased content of atorvastatin in this organ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1339-63-5 (Ubiquinone). A0JWA85V8F (Atorvastatin). BBX060AN9V (Hydrogen Peroxide). EC 2-3-3-1 (Citrate (si)-Synthase). EJ27X76M46 (coenzyme Q10).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41598-021-81846-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Christiansen&issn=2045-2322&title=Scientific+Reports&atitle=Atorvastatin+impairs+liver+mitochondrial+function+in+obese+Gottingen+Minipigs+but+heart+and+skeletal+muscle+are+not+affected.&volume=11&issue=1&spage=2167&epage=&date=2021&doi=10.1038%2Fs41598-021-81846-9&pmid=33500513&sid=OVID:medline
+
+<978>
+Unique Identifier
+ 33478525
+Title
+ Impact of insulin resistance on subclinical left ventricular dysfunction in normal weight and overweight/obese japanese subjects in a general community.
+Source
+ Cardiovascular Diabetology. 20(1):22, 2021 01 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hirose K; Nakanishi K; Daimon M; Sawada N; Yoshida Y; Iwama K; Yamamoto Y; Ishiwata J; Hirokawa M; Koyama K; Nakao T; Morita H; Di Tullio MR; Homma S; Komuro I
+Authors Full Name
+ Hirose, Kazutoshi; Nakanishi, Koki; Daimon, Masao; Sawada, Naoko; Yoshida, Yuriko; Iwama, Kentaro; Yamamoto, Yuko; Ishiwata, Jumpei; Hirokawa, Megumi; Koyama, Katsuhiro; Nakao, Tomoko; Morita, Hiroyuki; Di Tullio, Marco R; Homma, Shunichi; Komuro, Issei.
+Institution
+ Hirose, Kazutoshi. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Nakanishi, Koki. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan. knakanishi82@gmail.com.
+ Daimon, Masao. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Daimon, Masao. Department of Clinical Laboratory, The University of Tokyo, Tokyo, Japan.
+ Sawada, Naoko. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Yoshida, Yuriko. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Iwama, Kentaro. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Yamamoto, Yuko. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Ishiwata, Jumpei. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Hirokawa, Megumi. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Koyama, Katsuhiro. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Nakao, Tomoko. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Morita, Hiroyuki. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+ Di Tullio, Marco R. Department of Medicine, Columbia University, New York, NY, USA.
+ Homma, Shunichi. Department of Medicine, Columbia University, New York, NY, USA.
+ Komuro, Issei. Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
+MeSH Subject Headings
+ Aged
+ Asymptomatic Diseases
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Cross-Sectional Studies
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ *Diabetes Mellitus/ep [Epidemiology]
+ Echocardiography, Doppler
+ Female
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Tokyo/ep [Epidemiology]
+ Ventricular Dysfunction, Left/dg [Diagnostic Imaging]
+ *Ventricular Dysfunction, Left/ep [Epidemiology]
+ Ventricular Dysfunction, Left/pp [Physiopathology]
+ Ventricular Function, Left
+Keyword Heading
+ Insulin resistance
+ Left ventricular global longitudinal strain
+ Speckle-tracking echocardiography
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Insulin resistance carries increased risk of heart failure, although the pathophysiological mechanisms remain unclear. LV global longitudinal strain (LVGLS) assessed by speckle-tracking echocardiography has emerged as an important tool to detect early LV systolic abnormalities. This study aimed to investigate the association between insulin resistance and subclinical left ventricular (LV) dysfunction in a sample of the general population without overt cardiac disease.
+
+ METHODS: We investigated 539 participants who voluntarily underwent extensive cardiovascular health check including laboratory test and speckle-tracking echocardiography. Glycemic profiles were categorized into 3 groups according to homeostatic model assessment of insulin resistance (HOMA-IR): absence of insulin resistance (HOMA-IR < 1.5), presence of insulin resistance (HOMA-IR >= 1.5) and diabetes mellitus (DM). Multivariable logistic regression models were conducted to evaluate the association between abnormal glucose metabolism and impaired LVGLS (> - 16.65%).
+
+ RESULTS: Forty-five (8.3%) participants had DM and 66 (12.2%) had abnormal HOMA-IR. LV mass index and E/e' ratio did not differ between participants with and without abnormal HOMA-IR, whereas abnormal HOMA-IR group had significantly decreased LVGLS (- 17.6 +/- 2.6% vs. - 19.7 +/- 3.1%, p < 0.05). The prevalence of impaired LVGLS was higher in abnormal HOMA-IR group compared with normal HOMA-IR group (42.4% vs. 14.0%) and similar to that of DM (48.9%). In multivariable analyses, glycemic abnormalities were significantly associated with impaired LVGLS, independent of traditional cardiovascular risk factors and pertinent laboratory and echocardiographic parameters [adjusted odds ratio (OR) 2.38, p = 0.007 for abnormal HOMA-IR; adjusted OR 3.02, p = 0.003 for DM]. The independent association persisted even after adjustment for waist circumference as a marker of abdominal adiposity. Sub-group analyses stratified by body mass index showed significant association between abnormal HOMA-IR and impaired LVGLS in normal weight individuals (adjusted OR 4.59, p = 0.001), but not in overweight/obese individuals (adjusted OR 1.62, p = 0.300).
+
+ CONCLUSIONS: In the general population without overt cardiac disease, insulin resistance carries independent risk for subclinical LV dysfunction, especially in normal weight individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1186%2fs12933-020-01201-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hirose&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Impact+of+insulin+resistance+on+subclinical+left+ventricular+dysfunction+in+normal+weight+and+overweight%2Fobese+japanese+subjects+in+a+general+community.&volume=20&issue=1&spage=22&epage=&date=2021&doi=10.1186%2Fs12933-020-01201-6&pmid=33478525&sid=OVID:medline
+
+<979>
+Unique Identifier
+ 33471027
+Title
+ Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women.
+Source
+ JAMA Cardiology. 6(4):437-447, 2021 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dugani SB; Moorthy MV; Li C; Demler OV; Alsheikh-Ali AA; Ridker PM; Glynn RJ; Mora S
+Authors Full Name
+ Dugani, Sagar B; Moorthy, M Vinayaga; Li, Chunying; Demler, Olga V; Alsheikh-Ali, Alawi A; Ridker, Paul M; Glynn, Robert J; Mora, Samia.
+Institution
+ Dugani, Sagar B. Center for Lipid Metabolomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Dugani, Sagar B. Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota.
+ Moorthy, M Vinayaga. Center for Lipid Metabolomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Moorthy, M Vinayaga. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Li, Chunying. Center for Lipid Metabolomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Li, Chunying. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Demler, Olga V. Center for Lipid Metabolomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Demler, Olga V. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Alsheikh-Ali, Alawi A. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
+ Ridker, Paul M. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Ridker, Paul M. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Glynn, Robert J. Center for Lipid Metabolomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Glynn, Robert J. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Mora, Samia. Center for Lipid Metabolomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Mora, Samia. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+ Mora, Samia. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
+MeSH Subject Headings
+ Age Factors
+ Age of Onset
+ Aged
+ Apolipoproteins B/bl [Blood]
+ Biomarkers/bl [Blood]
+ Cholesterol, HDL/bl [Blood]
+ Cholesterol, LDL/bl [Blood]
+ Coronary Disease/bl [Blood]
+ Coronary Disease/ep [Epidemiology]
+ *Coronary Disease/et [Etiology]
+ Female
+ Heart Disease Risk Factors
+ Humans
+ Hypertension/bl [Blood]
+ Hypertension/co [Complications]
+ Incidence
+ *Inflammation/bl [Blood]
+ Insulin Resistance
+ *Lipids/bl [Blood]
+ Metabolic Syndrome/bl [Blood]
+ Middle Aged
+ Obesity/co [Complications]
+ Proportional Hazards Models
+ Prospective Studies
+ Smoking/ae [Adverse Effects]
+ Triglycerides/bl [Blood]
+ United States/ep [Epidemiology]
+Abstract
+ Importance: Risk profiles for premature coronary heart disease (CHD) are unclear.
+
+ Objective: To examine baseline risk profiles for incident CHD in women by age at onset.
+
+ Design, Setting, and Participants: A prospective cohort of US female health professionals participating in the Women's Health Study was conducted; median follow-up was 21.4 years. Participants included 28024 women aged 45 years or older without known cardiovascular disease. Baseline profiles were obtained from April 30, 1993, to January 24, 1996, and analyses were conducted from October 1, 2017, to October 1, 2020.
+
+ Exposures: More than 50 clinical, lipid, inflammatory, and metabolic risk factors and biomarkers.
+
+ Main Outcomes and Measures: Four age groups were examined (<55, 55 to <65, 65 to <75, and >=75 years) for CHD onset, and adjusted hazard ratios (aHRs) were calculated using stratified Cox proportional hazard regression models with age as the time scale and adjusting for clinical factors. Women contributed to different age groups over time.
+
+ Results: Of the clinical factors in the women, diabetes had the highest aHR for CHD onset at any age, ranging from 10.71 (95% CI, 5.57-20.60) at CHD onset in those younger than 55 years to 3.47 (95% CI, 2.47-4.87) at CHD onset in those 75 years or older. Risks that were also noted for CHD onset in participants younger than 55 years included metabolic syndrome (aHR, 6.09; 95% CI, 3.60-10.29), hypertension (aHR, 4.58; 95% CI, 2.76-7.60), obesity (aHR, 4.33; 95% CI, 2.31-8.11), and smoking (aHR, 3.92; 95% CI, 2.32-6.63). Myocardial infarction in a parent before age 60 years was associated with 1.5- to 2-fold risk of CHD in participants up to age 75 years. From approximately 50 biomarkers, lipoprotein insulin resistance had the highest standardized aHR: 6.40 (95% CI, 3.14-13.06) for CHD onset in women younger than 55 years, attenuating with age. In comparison, weaker but significant associations with CHD in women younger than 55 years were noted (per SD increment) for low-density lipoprotein cholesterol (aHR, 1.38; 95% CI, 1.10-1.74), non-high-density lipoprotein cholesterol (aHR, 1.67; 95% CI, 1.36-2.04), apolipoprotein B (aHR, 1.89; 95% CI, 1.52-2.35), triglycerides (aHR, 2.14; 95% CI, 1.72-2.67), and inflammatory biomarkers (1.2- to 1.8-fold)-all attenuating with age. Some biomarkers had similar CHD age associations (eg, physical inactivity, lipoprotein[a], total high-density lipoprotein particles), while a few had no association with CHD onset at any age. Most risk factors and biomarkers had associations that attenuated with increasing age at onset.
+
+ Conclusions and Relevance: In this cohort study, diabetes and insulin resistance, in addition to hypertension, obesity, and smoking, appeared to be the strongest risk factors for premature onset of CHD. Most risk factors had attenuated relative rates at older ages.
+Registry Number/Name of Substance
+ 0 (Apolipoproteins B). 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Lipids). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1001%2fjamacardio.2020.7073
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dugani&issn=2380-6591&title=JAMA+Cardiology&atitle=Association+of+Lipid%2C+Inflammatory%2C+and+Metabolic+Biomarkers+With+Age+at+Onset+for+Incident+Coronary+Heart+Disease+in+Women.&volume=6&issue=4&spage=437&epage=447&date=2021&doi=10.1001%2Fjamacardio.2020.7073&pmid=33471027&sid=OVID:medline
+
+<980>
+Unique Identifier
+ 33467738
+Title
+ The Predictive Value of miR-16, -29a and -134 for Early Identification of Gestational Diabetes: A Nested Analysis of the DALI Cohort.
+Source
+ Cells. 10(1), 2021 01 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sorensen AE; van Poppel MNM; Desoye G; Damm P; Simmons D; Jensen DM; Dalgaard LT
+Author NameID
+ Sorensen, Anja Elaine; ORCID: https://orcid.org/0000-0001-7557-5376
+ van Poppel, Mireille N M; ORCID: https://orcid.org/0000-0001-5694-4324
+ Desoye, Gernot; ORCID: https://orcid.org/0000-0002-5715-3230
+ Damm, Peter; ORCID: https://orcid.org/0000-0002-2067-5246
+ Simmons, David; ORCID: https://orcid.org/0000-0003-0560-0761
+ Dalgaard, Louise Torp; ORCID: https://orcid.org/0000-0002-3598-2775
+Corporate Author
+ The DALI Core Investigator Group
+Authors Full Name
+ Sorensen, Anja Elaine; van Poppel, Mireille N M; Desoye, Gernot; Damm, Peter; Simmons, David; Jensen, Dorte Moller; Dalgaard, Louise Torp.
+Institution
+ Sorensen, Anja Elaine. Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.
+ van Poppel, Mireille N M. Institute of Human Movement Science, Sport and Health, University of Graz, 8010 Graz, Austria.
+ Desoye, Gernot. Department of Obstetrics and Gynecology, Medizinische Universitaet Graz, 8036 Graz, Austria.
+ Desoye, Gernot. Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, Department of Clinical Medicine, University of Copenhagen, 2100 Copenhagen, Denmark.
+ Damm, Peter. Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, Department of Clinical Medicine, University of Copenhagen, 2100 Copenhagen, Denmark.
+ Simmons, David. Macarthur Clinical School, Western Sydney University, Sydney 2560, Australia.
+ Jensen, Dorte Moller. Steno Diabetes Center Odense, Department of Gynecology and Obstetrics, Odense University Hospital, 5000 Odense, Denmark.
+ Jensen, Dorte Moller. Department of Gynecology and Obstetrics, Odense University Hospital, 5000 Odense, Denmark.
+ Jensen, Dorte Moller. Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.
+ Dalgaard, Louise Torp. Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.
+MeSH Subject Headings
+ Adult
+ Anthropometry
+ Area Under Curve
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ *Diabetes, Gestational/di [Diagnosis]
+ Female
+ Humans
+ Life Style
+ *MicroRNAs/bl [Blood]
+ Obesity
+ Predictive Value of Tests
+ Pregnancy
+ RNA, Small Untranslated/bl [Blood]
+ ROC Curve
+ Real-Time Polymerase Chain Reaction
+ Risk Assessment
+ Young Adult
+Keyword Heading
+ Gestational diabetes mellitus
+ circulating microRNA
+ miR-122-5p
+ miR-134-5p
+ miR-16-5p
+ miR-29a-3p
+ microRNAs
+ obesity
+ predictive biomarker
+ pregnancy
+ randomized control trial
+ serum
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Early identification of gestational diabetes mellitus (GDM) aims to reduce the risk of adverse maternal and perinatal outcomes. Currently, no circulating biomarker has proven clinically useful for accurate prediction of GDM. In this study, we tested if a panel of small non-coding circulating RNAs could improve early prediction of GDM. We performed a nested case-control study of participants from the European multicenter 'Vitamin D and lifestyle intervention for GDM prevention (DALI)' trial using serum samples from obese pregnant women (BMI >= 29 kg/m2) entailing 82 GDM cases (early- and late- GDM), and 41 age- and BMI-matched women with normal glucose tolerance (NGT) throughout pregnancy (controls). Anthropometric, clinical and biochemical characteristics were obtained at baseline (<20 weeks of gestation) and throughout gestation. Baseline serum microRNAs (miRNAs) were measured using quantitative real time PCR (qPCR). Elevated miR-16-5p, -29a-3p, and -134-5p levels were observed in women, who were NGT at baseline and later developed GDM, compared with controls who remained NGT. A combination of the three miRNAs could distinguish later GDM from NGT cases (AUC 0.717, p = 0.001, compared with fasting plasma glucose (AUC 0.687, p = 0.004)) as evaluated by area under the curves (AUCs) using Receiver Operator Characteristics (ROC) analysis. Elevated levels of individual miRNAs or a combination hereof were associated with higher odds ratios of GDM. Conclusively, circulating miRNAs early in pregnancy could serve as valuable predictive biomarkers of GDM.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN134 microRNA, human). 0 (MIRN16 microRNA, human). 0 (MIRN29a microRNA, human). 0 (MicroRNAs). 0 (RNA, Small Untranslated).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fcells10010170
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sorensen&issn=2073-4409&title=Cells&atitle=The+Predictive+Value+of+miR-16%2C+-29a+and+-134+for+Early+Identification+of+Gestational+Diabetes%3A+A+Nested+Analysis+of+the+DALI+Cohort.&volume=10&issue=1&spage=&epage=&date=2021&doi=10.3390%2Fcells10010170&pmid=33467738&sid=OVID:medline
+
+<981>
+Unique Identifier
+ 33466578
+Title
+ Inflammatory Markers and Hepcidin are Elevated but Serum Iron is Lower in Obese Women of Reproductive Age.
+Source
+ Nutrients. 13(1), 2021 Jan 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aguree S; Reddy MB
+Author NameID
+ Aguree, Sixtus; ORCID: https://orcid.org/0000-0002-2374-4462
+ Reddy, Manju B; ORCID: https://orcid.org/0000-0002-2294-0701
+Authors Full Name
+ Aguree, Sixtus; Reddy, Manju B.
+Institution
+ Aguree, Sixtus. Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA.
+ Reddy, Manju B. Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Ferritins/bl [Blood]
+ *Hepcidins/bl [Blood]
+ Humans
+ Inflammation
+ *Iron/bl [Blood]
+ *Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ BMI
+ ferritin
+ hepcidin
+ inflammation
+ serum iron
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Limited evidence suggests that serum iron and hepcidin concentrations are dysregulated in obesity and inflammation. The objective of the present study was to compare C-reactive protein, interleukin-6, circulating levels of hepcidin, serum lipids, and iron status in obese vs. normal-weight women of childbearing age. Healthy women aged 18-30 years were recruited for the study (n = 47: 25 obese and 22 normal weight). Fasting blood samples were obtained to measure serum lipids (total cholesterol, HDL, LDL cholesterol, triglycerides, non-HDL cholesterol), complete blood count, serum iron, total iron-binding capacity, transferrin saturation, serum ferritin, hepcidin, C-reactive protein, and interleukin-6. Obese women had significantly higher mean serum C-reactive protein (p < 0.001), interleukin-6 (p < 0.001), hepcidin (p = 0.024), triglycerides (p < 0.001) and total cholesterol/HDL ratio (p < 0.001) but lower HDL (p = 0.001) and serum iron/hepcidin ratio (p = 0.011) compared with normal-weight women. BMI correlated positively with inflammatory markers, triglycerides, LDL and total cholesterol/HDL ratio, and negatively with HDL and serum iron/hepcidin ratio. Serum iron correlated negatively with ferritin in the obese group (p = 0.030) but positively in normal weight women (p = 0.002). BMI and ferritin were the only predictors of serum iron/hepcidin ratio accounting for 23% of the variation among subjects. Studies are needed to examine anti-inflammatory dietary approaches that can improve iron biomarkers in obese women.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hepcidins). 9007-73-2 (Ferritins). E1UOL152H7 (Iron).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fnu13010217
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aguree&issn=2072-6643&title=Nutrients&atitle=Inflammatory+Markers+and+Hepcidin+are+Elevated+but+Serum+Iron+is+Lower+in+Obese+Women+of+Reproductive+Age.&volume=13&issue=1&spage=&epage=&date=2021&doi=10.3390%2Fnu13010217&pmid=33466578&sid=OVID:medline
+
+<982>
+Unique Identifier
+ 33461313
+Title
+ Effect of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Cardiac Remodeling as Assessed by Cardiac Biomarker and Magnetic Resonance Imaging in Nonobese and Obese Adults.
+Source
+ Hypertension. 77(3):980-992, 2021 03 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xu L; Keenan BT; Maislin D; Gislason T; Benediktsdottir B; Gudmundsdottir S; Gardarsdottir M; Staley B; Pack FM; Guo X; Feng Y; Chahwala J; Manaktala P; Hussein A; Reddy-Koppula M; Hashmath Z; Lee J; Townsend RR; Schwab RJ; Pack AI; Kuna ST; Chirinos JA
+Authors Full Name
+ Xu, Liyue; Keenan, Brendan T; Maislin, David; Gislason, Thorarinn; Benediktsdottir, Bryndis; Gudmundsdottir, Sigrun; Gardarsdottir, Marianna; Staley, Bethany; Pack, Frances M; Guo, Xiaofeng; Feng, Yuan; Chahwala, Jugal; Manaktala, Pritika; Hussein, Anila; Reddy-Koppula, Maheshwara; Hashmath, Zeba; Lee, Jonathan; Townsend, Raymond R; Schwab, Richard J; Pack, Allan I; Kuna, Samuel T; Chirinos, Julio A.
+Institution
+ Xu, Liyue. From the Sleep Center, Peking University People's Hospital, Beijing, China (L.X.).
+ Xu, Liyue. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Keenan, Brendan T. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Maislin, David. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Gislason, Thorarinn. Sleep Department, Landspitali (T.G., B.B., S.G.), The National University Hospital of Iceland, Reykjavik.
+ Gislason, Thorarinn. Faculty of Medicine, University of Iceland, Reykjavik, Iceland (T.G., B.B.).
+ Benediktsdottir, Bryndis. Sleep Department, Landspitali (T.G., B.B., S.G.), The National University Hospital of Iceland, Reykjavik.
+ Benediktsdottir, Bryndis. Faculty of Medicine, University of Iceland, Reykjavik, Iceland (T.G., B.B.).
+ Gudmundsdottir, Sigrun. Sleep Department, Landspitali (T.G., B.B., S.G.), The National University Hospital of Iceland, Reykjavik.
+ Gardarsdottir, Marianna. Department of Radiology (M.G.), The National University Hospital of Iceland, Reykjavik.
+ Staley, Bethany. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Pack, Frances M. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Guo, Xiaofeng. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Feng, Yuan. Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.F.).
+ Chahwala, Jugal. Cardiovascular Division, Department of Medicine (J.C., PM., A.H., M.R.-K., Z.H., J.L., J.A.C.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Manaktala, Pritika. Cardiovascular Division, Department of Medicine (J.C., PM., A.H., M.R.-K., Z.H., J.L., J.A.C.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Hussein, Anila. Cardiovascular Division, Department of Medicine (J.C., PM., A.H., M.R.-K., Z.H., J.L., J.A.C.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Reddy-Koppula, Maheshwara. Cardiovascular Division, Department of Medicine (J.C., PM., A.H., M.R.-K., Z.H., J.L., J.A.C.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Hashmath, Zeba. Cardiovascular Division, Department of Medicine (J.C., PM., A.H., M.R.-K., Z.H., J.L., J.A.C.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Lee, Jonathan. Cardiovascular Division, Department of Medicine (J.C., PM., A.H., M.R.-K., Z.H., J.L., J.A.C.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Townsend, Raymond R. Renal-Electrolyte and Hypertension Division (R.R.T.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Schwab, Richard J. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Pack, Allan I. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Kuna, Samuel T. Division of Sleep Medicine, Department of Medicine (L.X., B.T.K., D.M., B.S., F.M.P., X.G., R.J.S., A.I.P., S.T.K.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+ Kuna, Samuel T. Sleep Medicine Section, Crescenz Veterans Affairs Medical Center, Philadelphia (S.T.K.).
+ Chirinos, Julio A. Cardiovascular Division, Department of Medicine (J.C., PM., A.H., M.R.-K., Z.H., J.L., J.A.C.), Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
+MeSH Subject Headings
+ Adult
+ Atrial Remodeling/ph [Physiology]
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ *Continuous Positive Airway Pressure/mt [Methods]
+ Female
+ Heart/dg [Diagnostic Imaging]
+ *Heart/pp [Physiopathology]
+ Humans
+ *Magnetic Resonance Imaging/mt [Methods]
+ Male
+ Middle Aged
+ Natriuretic Peptide, Brain/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Peptide Fragments/bl [Blood]
+ Polysomnography/mt [Methods]
+ Sleep Apnea, Obstructive/di [Diagnosis]
+ Sleep Apnea, Obstructive/pp [Physiopathology]
+ *Sleep Apnea, Obstructive/th [Therapy]
+ Ventricular Remodeling/ph [Physiology]
+Keyword Heading
+ magnetic resonance imaging
+ natriuretic peptide, brain
+ obesity
+ sleep apnea, obstructive
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ It is unknown whether obesity modifies the effect of obstructive sleep apnea (OSA) and positive airway pressure (PAP) therapy on cardiac remodeling and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. We compared NT-proBNP and cardiac magnetic resonance imaging in adults without OSA (n=56) and nonobese (n=73; body mass index <30 kg/m2) and obese (n=136; body mass index >=30 kg/m2) adults with OSA. We also investigated these traits in nonobese (n=45) and obese (n=78) participants with OSA adherent to 4 months of PAP treatment. At baseline, left ventricular mass to end-diastolic volume ratio, a measure of left ventricular concentricity, was greater in both nonobese and obese participants with OSA compared with those without OSA. Participants with OSA and obesity exhibited reduced phasic right atrial function. No significant differences in baseline NT-proBNP were observed across groups. The effect of PAP treatment on NT-proBNP and left atrial volume index was significantly modified by obesity. In nonobese participants, PAP therapy was associated with a decrease in NT-proBNP (P<0.0001) without a change in left atrial volume index, whereas in obese participants, PAP was associated with an increase in left atrial volume index (P=0.006) without a change in NT-proBNP. OSA was associated with left ventricular concentric remodeling independent of obesity and right atrial dysfunction in participants who were obese. PAP treatment was associated with reduced NT-proBNP in nonobese participants with OSA, but left atrial enlargement in obese participants with OSA, suggesting that PAP-induced reduction in BNP release (which is known to occur during obstructive apnea episodes) may lead to volume retention in obese participants with OSA. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01578031.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1161%2fHYPERTENSIONAHA.120.15882
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xu&issn=0194-911X&title=Hypertension&atitle=Effect+of+Obstructive+Sleep+Apnea+and+Positive+Airway+Pressure+Therapy+on+Cardiac+Remodeling+as+Assessed+by+Cardiac+Biomarker+and+Magnetic+Resonance+Imaging+in+Nonobese+and+Obese+Adults.&volume=77&issue=3&spage=980&epage=992&date=2021&doi=10.1161%2FHYPERTENSIONAHA.120.15882&pmid=33461313&sid=OVID:medline
+
+<983>
+Unique Identifier
+ 33460456
+Title
+ Metabolically healthy obesity and lipids may be protective factors for pathological changes of alzheimer's disease in cognitively normal adults.
+Source
+ Journal of Neurochemistry. 157(3):834-845, 2021 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang SJ; Ma YH; Bi YL; Shen XN; Hou XH; Cao XP; Ou YN; Zhao B; Dong Q; Tan L; Yu JT
+Author NameID
+ Yu, Jin-Tai; ORCID: https://orcid.org/0000-0002-7686-0547
+Authors Full Name
+ Huang, Shu-Juan; Ma, Ya-Hui; Bi, Yan-Lin; Shen, Xue-Ning; Hou, Xiao-He; Cao, Xi-Peng; Ou, Ya-Nan; Zhao, Bing; Dong, Qiang; Tan, Lan; Yu, Jin-Tai.
+Institution
+ Huang, Shu-Juan. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Ma, Ya-Hui. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Bi, Yan-Lin. Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Shen, Xue-Ning. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
+ Hou, Xiao-He. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Cao, Xi-Peng. Clinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Ou, Ya-Nan. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Zhao, Bing. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Dong, Qiang. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
+ Tan, Lan. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Yu, Jin-Tai. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
+MeSH Subject Headings
+ Aged
+ *Alzheimer Disease/pc [Prevention & Control]
+ Apolipoprotein E4/ge [Genetics]
+ Biomarkers/cf [Cerebrospinal Fluid]
+ Body Mass Index
+ China
+ Cholesterol/bl [Blood]
+ *Cognition/ph [Physiology]
+ Databases, Factual
+ Female
+ Health Status
+ Humans
+ Life Style
+ *Lipid Metabolism/ph [Physiology]
+ Lipoproteins, LDL/cf [Cerebrospinal Fluid]
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+ *Protective Factors
+ tau Proteins/cf [Cerebrospinal Fluid]
+Keyword Heading
+ Alzheimer's disease
+ cerebrospinal fluid biomarkers
+ metabolically healthy obesity
+ preclinical stage
+ serum lipid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The associations between obesity and Alzheimer's disease (AD) at different ages have been debated. Recent evidence implied the protective effects of metabolically healthy obesity on AD. We hypothesized that obesity and lipids could mitigate the detrimental impacts of AD pathological changes among metabolically healthy individuals in late life. In this study, a total of 604 metabolically healthy participants with normal cognition were included from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) database. Multiple linear regression models were used to test the associations of body mass index (BMI) or lipids with cerebrospinal fluid (CSF) biomarkers after adjustment for age, gender, education, and Apolipoprotein E-e4 (APOE-e4). The results showed the lower CSF levels of total tau protein (t-tau: p = .0048) and phosphorylated tau protein (p-tau: p = .0035) in obese participants than in non-obese participants, even after correcting for covariates. Moreover in late life, higher BMI was associated with decreased CSF t-tau (beta: -0.15, p = .0145) and p-tau (beta: -0.17, p = .0052). As for lipids, higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were associated with decreased CSF t-tau (TC: beta: -0.16, p = .0115; LDL-C: beta: -0.16, p = .0082) and p-tau (TC: beta: -0.15, p = .0177; LDL-C: beta: -0.14, p = .0225) in obese participants. Furthermore, these associations were only significant in participants with late-life obesity and APOE-e4 non-carriers. Overall, in a cognitively normal population, we found metabolically healthy obesity and lipids in late life might be protective factors for neurodegenerative changes. Copyright © 2021 International Society for Neurochemistry.
+Registry Number/Name of Substance
+ 0 (Apolipoprotein E4). 0 (Biomarkers). 0 (Lipoproteins, LDL). 0 (MAPT protein, human). 0 (tau Proteins). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fjnc.15306
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=0022-3042&title=Journal+of+Neurochemistry&atitle=Metabolically+healthy+obesity+and+lipids+may+be+protective+factors+for+pathological+changes+of+alzheimer%27s+disease+in+cognitively+normal+adults.&volume=157&issue=3&spage=834&epage=845&date=2021&doi=10.1111%2Fjnc.15306&pmid=33460456&sid=OVID:medline
+
+<984>
+Unique Identifier
+ 33459647
+Title
+ Obesity and White Matter Neuroinflammation Related Edema in Alzheimer's Disease Dementia Biomarker Negative Cognitively Normal Individuals.
+Source
+ Journal of Alzheimer's Disease. 79(4):1801-1811, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ly M; Raji CA; Yu GZ; Wang Q; Wang Y; Schindler SE; An H; Samara A; Eisenstein SA; Hershey T; Smith G; Klein S; Liu J; Xiong C; Ances BM; Morris JC; Benzinger TLS
+Authors Full Name
+ Ly, Maria; Raji, Cyrus A; Yu, Gary Z; Wang, Qing; Wang, Yong; Schindler, Suzanne E; An, Hongyu; Samara, Amjad; Eisenstein, Sarah A; Hershey, Tamara; Smith, Gordon; Klein, Samuel; Liu, Jingxia; Xiong, Chengjie; Ances, Beau M; Morris, John C; Benzinger, Tammie L S.
+Institution
+ Ly, Maria. University of Pittsburgh Medical Scientist Training Program, Pittsburgh, PA, USA.
+ Raji, Cyrus A. Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University in St. Louis, St. Louis, MO, USA.
+ Raji, Cyrus A. Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
+ Yu, Gary Z. University of Pittsburgh Medical Scientist Training Program, Pittsburgh, PA, USA.
+ Wang, Qing. Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University in St. Louis, St. Louis, MO, USA.
+ Wang, Yong. Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University in St. Louis, St. Louis, MO, USA.
+ Schindler, Suzanne E. Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
+ An, Hongyu. Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University in St. Louis, St. Louis, MO, USA.
+ Samara, Amjad. Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
+ Eisenstein, Sarah A. Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University in St. Louis, St. Louis, MO, USA.
+ Eisenstein, Sarah A. Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
+ Hershey, Tamara. Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University in St. Louis, St. Louis, MO, USA.
+ Hershey, Tamara. Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
+ Hershey, Tamara. Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
+ Hershey, Tamara. Department of Psychological & Brain Sciences, Washington University School of Medicine, St. Louis, MO, USA.
+ Smith, Gordon. Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO, USA.
+ Klein, Samuel. Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO, USA.
+ Liu, Jingxia. Department of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA.
+ Xiong, Chengjie. Department of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA.
+ Ances, Beau M. Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
+ Morris, John C. Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
+ Benzinger, Tammie L S. Mallinckrodt Institute of Radiology, Division of Neuroradiology, Washington University in St. Louis, St. Louis, MO, USA.
+MeSH Subject Headings
+ Aged
+ Alzheimer Disease
+ Biomarkers/cf [Cerebrospinal Fluid]
+ *Brain/pa [Pathology]
+ Brain Edema/et [Etiology]
+ Brain Edema/pa [Pathology]
+ Dementia
+ Female
+ Humans
+ *Inflammation/et [Etiology]
+ *Inflammation/pa [Pathology]
+ Magnetic Resonance Imaging
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Risk Factors
+ *White Matter/pa [Pathology]
+Keyword Heading
+ Alzheimer's disease
+ neuroinflammation imaging
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is related to quantitative neuroimaging abnormalities including reduced gray matter volumes and impaired white matter microstructural integrity, although the underlying mechanisms are not well understood.
+
+ OBJECTIVE: We assessed influence of obesity on neuroinflammation imaging that may mediate brain morphometric changes. Establishing the role of neuroinflammation in obesity will enhance understanding of this modifiable disorder as a risk factor for Alzheimer's disease (AD) dementia.
+
+ METHODS: We analyzed brain MRIs from 104 cognitively normal participants (CDR = 0) and biomarker negativity for CSF amyloid or tau. We classified body mass index (BMI) as normal (BMI <25, N = 62) or overweight and obese (BMI >=25, N = 42). Blood pressure was measured. BMI and blood pressure classifications were related to neuroinflammation imaging (NII) derived edema fraction in 17 white matter tracts. This metric was also correlated to hippocampal volumes and CSF biomarkers of inflammation and neurodegeneration: YKL-40, SNAP25, VILIP, tau, and NFL.
+
+ RESULTS: Participants with BMI <25 had lower NII-derived edema fraction, with protective effects of normal blood pressure. Statistically significant white matter tracts included the internal capsule, external capsule, and corona radiata, FDR correc-ted for multiple comparisons to alpha = 0.05. Higher NII-derived edema fractions in the internal capsule, corpus callosum, gyrus, and superior fronto-occipital fasciculus were related with smaller hippocampal volumes only in individuals with BMI >=25. There were no statistically significant correlations between NII-derived edema fraction and CSF biomarkers.
+
+ CONCLUSION: We demonstrate statistically significant relationships between neuroinflammation, elevated BMI, and hippocampal volume, raising implications for neuroinflammation mechanisms of obesity-related brain dysfunction in cognitively normal elderly.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3233%2fJAD-201242
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ly&issn=1387-2877&title=Journal+of+Alzheimer%27s+Disease&atitle=Obesity+and+White+Matter+Neuroinflammation+Related+Edema+in+Alzheimer%27s+Disease+Dementia+Biomarker+Negative+Cognitively+Normal+Individuals.&volume=79&issue=4&spage=1801&epage=1811&date=2021&doi=10.3233%2FJAD-201242&pmid=33459647&sid=OVID:medline
+
+<985>
+Unique Identifier
+ 33453048
+Title
+ The Interdependence of Blood Pressure and Glucose in Vietnam.
+Source
+ High Blood Pressure & Cardiovascular Prevention. 28(2):141-150, 2021 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nga TTT; Blizzard CL; Khue LN; Le Van Ngoc T; Bao TQ; Otahal P; Nelson MR; Magnussen CG; Van Tan B; Srikanth V; Thuy AB; Son HT; Hai PN; Mai TH; Callisaya M; Gall S
+Authors Full Name
+ Nga, Tran Thi Thu; Blizzard, Christopher Leigh; Khue, Luong Ngoc; Le Van Ngoc, Truong; Bao, Tran Quoc; Otahal, Petr; Nelson, Mark R; Magnussen, Costan G; Van Tan, Bui; Srikanth, Velandai; Thuy, Au Bich; Son, Ha Thai; Hai, Phung Ngoc; Mai, Tran Hoang; Callisaya, Michele; Gall, Seana.
+Institution
+ Nga, Tran Thi Thu. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Blizzard, Christopher Leigh. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia. Leigh.Blizzard@utas.edu.au.
+ Khue, Luong Ngoc. Medical Services Administration, Ministry of Health of the Socialist Republic of Vietnam, Hanoi, Vietnam.
+ Le Van Ngoc, Truong. Medical Services Administration, Ministry of Health of the Socialist Republic of Vietnam, Hanoi, Vietnam.
+ Bao, Tran Quoc. Medical Services Administration, Ministry of Health of the Socialist Republic of Vietnam, Hanoi, Vietnam.
+ Otahal, Petr. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Nelson, Mark R. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Magnussen, Costan G. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Magnussen, Costan G. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
+ Van Tan, Bui. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Srikanth, Velandai. Department of Medicine, Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
+ Thuy, Au Bich. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Son, Ha Thai. Medical Services Administration, Ministry of Health of the Socialist Republic of Vietnam, Hanoi, Vietnam.
+ Hai, Phung Ngoc. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Mai, Tran Hoang. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Callisaya, Michele. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+ Callisaya, Michele. Department of Medicine, Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
+ Gall, Seana. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Blood Pressure
+ Body Mass Index
+ Female
+ *Glucose Metabolism Disorders/bl [Blood]
+ Glucose Metabolism Disorders/di [Diagnosis]
+ Glucose Metabolism Disorders/ep [Epidemiology]
+ Humans
+ Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ *Hypertension/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Vietnam/ep [Epidemiology]
+ Waist Circumference
+Keyword Heading
+ Blood glucose
+ Blood pressure
+ Inter-relationship
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Modelling of associations of systolic blood pressure (BP) and blood glucose (BG) with their explanatory factors in separate regressions treats them as having independent biological mechanisms. This can lead to statistical inferences that are unreliable because the substantial overlap in their etiologic and disease mechanisms is ignored.
+
+ AIM: This study aimed to examine the relationship of systolic blood pressure (BP) and blood glucose (BG) with measures of obesity and central fat distribution and other factors whilst taking account of the inter-dependence between them.
+
+ METHODS: Participants (n = 14706, 53.5 % females) aged 25-64 years were selected by multi-stage stratified cluster sampling from eight provinces each representing one of the eight geographical regions of Vietnam. Measurements were made using the World Health Organization STEPS protocols.
+
+ RESULTS: Structural modelling identified direct effects for BG (men P = 0.000, women P = 0.029), age (men P = 0.000, women P = 0.000) and body mass index (BMI) (men P = 0.000, women P = 0.000) in the estimation of systolic BP, and for systolic BP (men P = 0.036, women P = 0.000) and waist circumference (WC) (men P = 0.032, women P = 0.009) in the estimation of BG. There were indirect effects of age, cholesterol, physical activity and tobacco smoking via their influence on WC and BMI. The errors in estimation of systolic BP and BG were correlated (men P = 0.000, women P = 0.004), the stability indices (men 0.466, women 0.495) showed the non-recursive models were stable, and the proportion of variance explained was mid-range (men 0.553, women 0.579).
+
+ CONCLUSION: This study provided statistical evidence of a feedback loop between systolic BP and BG. BMI and WC were confirmed to be their primary explanatory factors. Saturated fat intake and physical activity were identified as possible targets of intervention for overweight and obesity, and indirectly for reducing systolic BP and BG. Harmful/hazardous alcohol intake was identified as a target of intervention for systolic BP.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs40292-020-00431-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nga&issn=1120-9879&title=High+Blood+Pressure+%26+Cardiovascular+Prevention&atitle=The+Interdependence+of+Blood+Pressure+and+Glucose+in+Vietnam.&volume=28&issue=2&spage=141&epage=150&date=2021&doi=10.1007%2Fs40292-020-00431-9&pmid=33453048&sid=OVID:medline
+
+<986>
+Unique Identifier
+ 33445606
+Title
+ Paternal Methyl Donor Supplementation in Rats Improves Fertility, Physiological Outcomes, Gut Microbial Signatures and Epigenetic Markers Altered by High Fat/High Sucrose Diet.
+Source
+ International Journal of Molecular Sciences. 22(2), 2021 Jan 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chleilat F; Schick A; Deleemans JM; Reimer RA
+Author NameID
+ Chleilat, Faye; ORCID: https://orcid.org/0000-0002-0804-1611
+ Deleemans, Julie M; ORCID: https://orcid.org/0000-0001-8645-0990
+ Reimer, Raylene A; ORCID: https://orcid.org/0000-0001-5088-7947
+Authors Full Name
+ Chleilat, Faye; Schick, Alana; Deleemans, Julie M; Reimer, Raylene A.
+Institution
+ Chleilat, Faye. Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
+ Schick, Alana. International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
+ Deleemans, Julie M. Division of Medical Science, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
+ Deleemans, Julie M. Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
+ Reimer, Raylene A. Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
+ Reimer, Raylene A. Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/me [Metabolism]
+ Body Composition/ge [Genetics]
+ Diet, High-Fat
+ Dietary Supplements
+ *Epigenesis, Genetic/ge [Genetics]
+ Fathers
+ Female
+ Fertility/ge [Genetics]
+ *Gastrointestinal Microbiome/ge [Genetics]
+ Glucagon-Like Peptide 1/ge [Genetics]
+ Male
+ MicroRNAs/ge [Genetics]
+ Obesity/ge [Genetics]
+ Peptide YY/ge [Genetics]
+ Pregnancy
+ Prenatal Exposure Delayed Effects/ge [Genetics]
+ Rats
+ Rats, Sprague-Dawley
+ *Sucrose/me [Metabolism]
+Keyword Heading
+ DNMT
+ gut microbiota
+ insulin resistance
+ microRNA
+ one-carbon metabolism
+ paternal nutritional programming
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Increased consumption of high fat/sucrose (HF/S) diets has contributed to rising rates of obesity and its co-morbidities globally, while also negatively impacting male reproductive health. Our objective was to examine whether adding a methyl donor cocktail to paternal HF/S diet (HF/S+M) improves health status in fathers and offspring. From 3-12 weeks of age, male Sprague Dawley rats consumed a HF/S or HF/S+M diet. Offspring were followed until 16 weeks of age. Body composition, metabolic markers, gut microbiota, DNA methyltransferase (DNMT) and microRNA expression were measured in fathers and offspring. Compared to HF/S, paternal HF/S+M diet reduced fat mass in offspring (p < 0.005). HF/S+M fathers consumed 16% fewer kcal/day, which persisted in HF/S+M female offspring and was explained in part by changes in serum glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY) levels. Compared to HF/S, HF/S+M fathers had a 33% improvement in days until conception and 300% fewer stillbirths. In fathers, adipose tissue DNMT3a and hepatic miR-34a expression were reduced with HF/S+M. Adult male offspring showed upregulated miR-24, -33, -122a and -143 expression while females exhibited downregulated miR-33 expression. Fathers and offspring presented differences in gut microbial signatures. Supplementing a paternal HF/S diet with methyl-donors improved fertility, physiological outcomes, epigenetic and gut microbial signatures intergenerationally.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs). 106388-42-5 (Peptide YY). 57-50-1 (Sucrose). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.3390%2fijms22020689
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chleilat&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Paternal+Methyl+Donor+Supplementation+in+Rats+Improves+Fertility%2C+Physiological+Outcomes%2C+Gut+Microbial+Signatures+and+Epigenetic+Markers+Altered+by+High+Fat%2FHigh+Sucrose+Diet.&volume=22&issue=2&spage=689&epage=&date=2021&doi=10.3390%2Fijms22020689&pmid=33445606&sid=OVID:medline
+
+<987>
+Unique Identifier
+ 33435884
+Title
+ Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromso study.
+Source
+ BMC Cardiovascular Disorders. 21(1):29, 2021 01 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bekkelund SI
+Author NameID
+ Bekkelund, Svein Ivar; ORCID: https://orcid.org/0000-0002-8464-7199
+Authors Full Name
+ Bekkelund, Svein Ivar.
+Institution
+ Bekkelund, Svein Ivar. Department of Clinical Medicine, UiT - The Arctic University of Norway, 9037, Tromso, Norway. svein-ivar.bekkelund@uit.no.
+ Bekkelund, Svein Ivar. Department of Neurology, University Hospital of North Norway, 9038, Tromso, Norway. svein-ivar.bekkelund@uit.no.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Aged
+ Aged, 80 and over
+ *Alanine Transaminase/bl [Blood]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/eh [Ethnology]
+ Cross-Sectional Studies
+ Female
+ Heart Disease Risk Factors
+ Humans
+ Male
+ Middle Aged
+ Norway/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ Obesity/eh [Ethnology]
+ Prognosis
+ Risk Assessment
+ Sex Factors
+ *White People
+Keyword Heading
+ Age
+ Alanine aminotransferase
+ BMI
+ Population study
+ Sex difference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population.
+
+ METHODS: Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromso 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP).
+
+ RESULTS: Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88-1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86-0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found.
+
+ CONCLUSION: This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1186%2fs12872-020-01826-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bekkelund&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Serum+alanine+aminotransferase+activity+and+risk+factors+for+cardiovascular+disease+in+a+Caucasian+population%3A+the+Tromso+study.&volume=21&issue=1&spage=29&epage=&date=2021&doi=10.1186%2Fs12872-020-01826-1&pmid=33435884&sid=OVID:medline
+
+<988>
+Unique Identifier
+ 33432175
+Title
+ Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.
+Source
+ Nature Medicine. 27(2):321-332, 2021 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Asnicar F; Berry SE; Valdes AM; Nguyen LH; Piccinno G; Drew DA; Leeming E; Gibson R; Le Roy C; Khatib HA; Francis L; Mazidi M; Mompeo O; Valles-Colomer M; Tett A; Beghini F; Dubois L; Bazzani D; Thomas AM; Mirzayi C; Khleborodova A; Oh S; Hine R; Bonnett C; Capdevila J; Danzanvilliers S; Giordano F; Geistlinger L; Waldron L; Davies R; Hadjigeorgiou G; Wolf J; Ordovas JM; Gardner C; Franks PW; Chan AT; Huttenhower C; Spector TD; Segata N
+Author NameID
+ Asnicar, Francesco; ORCID: http://orcid.org/0000-0003-3732-1468
+ Valdes, Ana M; ORCID: http://orcid.org/0000-0003-1141-4471
+ Nguyen, Long H; ORCID: http://orcid.org/0000-0002-5436-4219
+ Piccinno, Gianmarco; ORCID: http://orcid.org/0000-0003-1947-1817
+ Drew, David A; ORCID: http://orcid.org/0000-0002-8813-0816
+ Gibson, Rachel; ORCID: http://orcid.org/0000-0002-5823-6468
+ Le Roy, Caroline; ORCID: http://orcid.org/0000-0002-0341-751X
+ Francis, Lucy; ORCID: http://orcid.org/0000-0003-0946-2634
+ Valles-Colomer, Mireia; ORCID: http://orcid.org/0000-0002-1988-6054
+ Beghini, Francesco; ORCID: http://orcid.org/0000-0002-8105-9607
+ Hine, Rachel; ORCID: http://orcid.org/0000-0003-2419-0382
+ Bonnett, Christopher; ORCID: http://orcid.org/0000-0002-0626-351X
+ Capdevila, Joan; ORCID: http://orcid.org/0000-0003-1658-1076
+ Danzanvilliers, Serge; ORCID: http://orcid.org/0000-0003-4647-9654
+ Waldron, Levi; ORCID: http://orcid.org/0000-0003-2725-0694
+ Davies, Richard; ORCID: http://orcid.org/0000-0003-2050-3994
+ Hadjigeorgiou, George; ORCID: http://orcid.org/0000-0001-7647-8471
+ Wolf, Jonathan; ORCID: http://orcid.org/0000-0002-0530-2257
+ Ordovas, Jose M; ORCID: http://orcid.org/0000-0002-7581-5680
+ Gardner, Christopher; ORCID: http://orcid.org/0000-0002-7596-1530
+ Chan, Andrew T; ORCID: http://orcid.org/0000-0001-7284-6767
+ Huttenhower, Curtis; ORCID: http://orcid.org/0000-0002-1110-0096
+ Spector, Tim D; ORCID: http://orcid.org/0000-0002-9795-0365
+ Segata, Nicola; ORCID: http://orcid.org/0000-0002-1583-5794
+Authors Full Name
+ Asnicar, Francesco; Berry, Sarah E; Valdes, Ana M; Nguyen, Long H; Piccinno, Gianmarco; Drew, David A; Leeming, Emily; Gibson, Rachel; Le Roy, Caroline; Khatib, Haya Al; Francis, Lucy; Mazidi, Mohsen; Mompeo, Olatz; Valles-Colomer, Mireia; Tett, Adrian; Beghini, Francesco; Dubois, Leonard; Bazzani, Davide; Thomas, Andrew Maltez; Mirzayi, Chloe; Khleborodova, Asya; Oh, Sehyun; Hine, Rachel; Bonnett, Christopher; Capdevila, Joan; Danzanvilliers, Serge; Giordano, Francesca; Geistlinger, Ludwig; Waldron, Levi; Davies, Richard; Hadjigeorgiou, George; Wolf, Jonathan; Ordovas, Jose M; Gardner, Christopher; Franks, Paul W; Chan, Andrew T; Huttenhower, Curtis; Spector, Tim D; Segata, Nicola.
+Institution
+ Asnicar, Francesco. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
+ Berry, Sarah E. Department of Nutritional Sciences, King's College London, London, UK. sarah.e.berry@kcl.ac.uk.
+ Valdes, Ana M. School of Medicine, University of Nottingham, Nottingham, UK.
+ Valdes, Ana M. Nottingham National Institute for Health Research Biomedical Research Centre, Nottingham, UK.
+ Nguyen, Long H. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
+ Piccinno, Gianmarco. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
+ Drew, David A. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
+ Leeming, Emily. Department of Twin Research, King's College London, London, UK.
+ Gibson, Rachel. Department of Nutritional Sciences, King's College London, London, UK.
+ Le Roy, Caroline. Department of Twin Research, King's College London, London, UK.
+ Khatib, Haya Al. Zoe Global Ltd, London, UK.
+ Francis, Lucy. Zoe Global Ltd, London, UK.
+ Mazidi, Mohsen. Department of Twin Research, King's College London, London, UK.
+ Mompeo, Olatz. Department of Twin Research, King's College London, London, UK.
+ Valles-Colomer, Mireia. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
+ Tett, Adrian. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
+ Beghini, Francesco. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
+ Dubois, Leonard. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
+ Bazzani, Davide. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
+ Thomas, Andrew Maltez. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
+ Mirzayi, Chloe. City University of New York, New York, NY, USA.
+ Khleborodova, Asya. City University of New York, New York, NY, USA.
+ Oh, Sehyun. City University of New York, New York, NY, USA.
+ Hine, Rachel. Zoe Global Ltd, London, UK.
+ Bonnett, Christopher. Zoe Global Ltd, London, UK.
+ Capdevila, Joan. Zoe Global Ltd, London, UK.
+ Danzanvilliers, Serge. Zoe Global Ltd, London, UK.
+ Giordano, Francesca. Zoe Global Ltd, London, UK.
+ Geistlinger, Ludwig. City University of New York, New York, NY, USA.
+ Waldron, Levi. City University of New York, New York, NY, USA.
+ Davies, Richard. Zoe Global Ltd, London, UK.
+ Hadjigeorgiou, George. Zoe Global Ltd, London, UK.
+ Wolf, Jonathan. Zoe Global Ltd, London, UK.
+ Ordovas, Jose M. Jean Mayer-United States Department of Agriculture-Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
+ Ordovas, Jose M. Institutos Madrileno de Estudios Avanzados Food Institute, Campus of International Excellence Universidad Autonoma de Madrid & Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
+ Gardner, Christopher. Stanford University, Stanford, CA, USA.
+ Franks, Paul W. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Franks, Paul W. Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Chan, Andrew T. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
+ Chan, Andrew T. Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Chan, Andrew T. The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
+ Huttenhower, Curtis. Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Huttenhower, Curtis. The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
+ Spector, Tim D. Department of Twin Research, King's College London, London, UK.
+ Segata, Nicola. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy. nicola.segata@unitn.it.
+ Segata, Nicola. European Institute of Oncology Scientific Institute for Research, Hospitalization and Healthcare, Milan, Italy. nicola.segata@unitn.it.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Blastocystis/ge [Genetics]
+ Blood Glucose/me [Metabolism]
+ Child
+ Diet/ae [Adverse Effects]
+ Fasting/me [Metabolism]
+ Feeding Behavior
+ Female
+ Food Microbiology
+ *Gastrointestinal Microbiome/ge [Genetics]
+ Glucose/ge [Genetics]
+ High-Throughput Nucleotide Sequencing
+ Humans
+ Male
+ *Metagenome/ge [Genetics]
+ *Microbiota/ge [Genetics]
+ Middle Aged
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ *Obesity/mi [Microbiology]
+ Postprandial Period/ge [Genetics]
+ Prevotella/ge [Genetics]
+ Prevotella/ip [Isolation & Purification]
+Abstract
+ The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agreement with circulating blood metabolites that are indicators of cardiovascular disease risk. While some microbes, such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, overall microbiome composition was predictive for a large panel of cardiometabolic blood markers including fasting and postprandial glycemic, lipemic and inflammatory indices. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favorable cardiometabolic and postprandial markers, indicating that our large-scale resource can potentially stratify the gut microbiome into generalizable health levels in individuals without clinically manifest disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). IY9XDZ35W2 (Glucose).
+Publication Type
+ Clinical Trial. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41591-020-01183-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Asnicar&issn=1078-8956&title=Nature+Medicine&atitle=Microbiome+connections+with+host+metabolism+and+habitual+diet+from+1%2C098+deeply+phenotyped+individuals.&volume=27&issue=2&spage=321&epage=332&date=2021&doi=10.1038%2Fs41591-020-01183-8&pmid=33432175&sid=OVID:medline
+
+<989>
+Unique Identifier
+ 33431344
+Title
+ Investigating IGF-II and IGF2R serum markers as predictors of body weight loss following an 8-week acute weight loss intervention: PREVIEW sub-study.
+Source
+ Obesity Research & Clinical Practice. 15(1):42-48, 2021 Jan-Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee KL; Silvestre MP; AlSaud NH; Fogelholm M; Raben A; Poppitt SD
+Authors Full Name
+ Lee, Kate L; Silvestre, Marta P; AlSaud, Nour H; Fogelholm, Mikael; Raben, Anne; Poppitt, Sally D.
+Institution
+ Lee, Kate L. Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address: kathryn.lee@auckland.ac.nz.
+ Silvestre, Marta P. Human Nutrition Unit, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; CINTESIS - Centro de Investigacao em Tecnologias e Servicos de Saude
+ NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisboa, Portugal.
+ AlSaud, Nour H. Human Nutrition Unit, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
+ Fogelholm, Mikael. Department of Food and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland.
+ Raben, Anne. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, DK-1958 Copenhagen, Denmark.
+ Poppitt, Sally D. Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Human Nutrition Unit, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Caloric Restriction
+ Humans
+ Insulin-Like Growth Factor II/an [Analysis]
+ *Insulin-Like Growth Factor II
+ New Zealand
+ Obesity/dh [Diet Therapy]
+ Obesity/eh [Ethnology]
+ Overweight/dh [Diet Therapy]
+ Overweight/eh [Ethnology]
+ Prediabetic State/dh [Diet Therapy]
+ Prediabetic State/eh [Ethnology]
+ *Receptor, IGF Type 2/bl [Blood]
+ *Weight Loss
+Keyword Heading
+ Diet
+ IGF
+ Lifestyle intervention
+ Obesity
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Weight reduction is effective in preventing T2D however, weight reduction and maintenance is difficult to achieve on a population scale. Serum insulin-like growth factor II (IGF-II) and IGF-II receptor (IGF2R) have been associated with diabetic status and body weight in prior studies and, in addition, IGF-II has been indicated as predictive of future weight change. We measured these serum markers in participants with obesity/overweight and prediabetes from the New Zealand arm of the PREVIEW lifestyle intervention randomised trial before and after an 8-week low energy diet (LED).
+
+ METHODS: Total IGF-II (n = 223) and soluble IGF2R (n = 151) were measured using commercial ELISA kits on fasted serum samples taken prior to an 8-week LED and also from participants completing the LED.
+
+ RESULTS: IGF-II levels were not correlated with baseline body weight although mean levels did significantly decrease following the LED. Change in IGF-II serum level was correlated to fasting glucose change (p = 0.04) but not to weight change. Baseline serum IGF2R was correlated with BMI (p = 0.007) and was significantly higher in Maori compared to European Caucasian participants independent of body weight (p = 0.0016). Following LED, IGF2R change was positively associated with weight change (p = 0.02) when corrected for ethnicity. Pre-LED levels of these serum markers were not predictive of the magnitude of weight loss over the 8 weeks.
+
+ CONCLUSION: Neither marker was useful in predicting magnitude of short-term weight loss. IGF2R is positively associated with BMI and is higher in Maori compared to European Caucasian individuals. Copyright © 2021 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Receptor, IGF Type 2). 67763-97-7 (Insulin-Like Growth Factor II).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.orcp.2020.12.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=1871-403X&title=Obesity+Research+%26+Clinical+Practice&atitle=Investigating+IGF-II+and+IGF2R+serum+markers+as+predictors+of+body+weight+loss+following+an+8-week+acute+weight+loss+intervention%3A+PREVIEW+sub-study.&volume=15&issue=1&spage=42&epage=48&date=2021&doi=10.1016%2Fj.orcp.2020.12.007&pmid=33431344&sid=OVID:medline
+
+<990>
+Unique Identifier
+ 33426749
+Title
+ Serum spexin concentration, body condition score and markers of obesity in dogs.
+Source
+ Journal of Veterinary Internal Medicine. 35(1):397-404, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kolodziejski PA; Pruszynska-Oszmalek E; Nowak T; Lukomska A; Sassek M; Wlodarek J; Nogowski L; Cieslak A; Nowak KW
+Author NameID
+ Kolodziejski, Pawel Antoni; ORCID: https://orcid.org/0000-0003-0715-0223
+Authors Full Name
+ Kolodziejski, Pawel Antoni; Pruszynska-Oszmalek, Ewa; Nowak, Tomasz; Lukomska, Anna; Sassek, Maciej; Wlodarek, Jan; Nogowski, Leszek; Cieslak, Adam; Nowak, Krzysztof W.
+Institution
+ Kolodziejski, Pawel Antoni. Department of Animal Physiology, Biochemistry and Biostructure Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Poznan, Poland.
+ Pruszynska-Oszmalek, Ewa. Department of Animal Physiology, Biochemistry and Biostructure Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Poznan, Poland.
+ Nowak, Tomasz. Department of Genetics and Animal Breeding, Animal Reproduction Unit, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Poznan, Poland.
+ Lukomska, Anna. Department of Preclinical Sciences and Infectious Diseases, Faculty of Veterinary Medicine and Animal Sciences, Poznan University of Life Sciences, Poznan, Poland.
+ Sassek, Maciej. Department of Animal Physiology, Biochemistry and Biostructure Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Poznan, Poland.
+ Wlodarek, Jan. Department of Preclinical Sciences and Infectious Diseases, Faculty of Veterinary Medicine and Animal Sciences, Poznan University of Life Sciences, Poznan, Poland.
+ Nogowski, Leszek. Department of Animal Physiology, Biochemistry and Biostructure Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Poznan, Poland.
+ Cieslak, Adam. Department of Animal Nutrition, Poznan University of Life Sciences, Poznan, Poland.
+ Nowak, Krzysztof W. Department of Animal Physiology, Biochemistry and Biostructure Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Poznan, Poland.
+MeSH Subject Headings
+ Adipose Tissue
+ Animals
+ Biomarkers
+ *Dog Diseases
+ Dogs
+ Leptin
+ Obesity/ve [Veterinary]
+ *Obesity
+ Prospective Studies
+Keyword Heading
+ BCS
+ hormones
+ insulin
+ metabolism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Spexin (SPX) is a peptide hormone that regulates body weight, adipose tissue metabolism, and food intake.
+
+ HYPOTHESIS: Serum SPX concentration correlates with body condition score (BCS) and markers of obesity in dogs.
+
+ ANIMALS: Fifty-seven dogs of varying body condition assessed using a 5-point BCS.
+
+ METHODS: Prospective, nonblinded, observational cohort study. Serum SPX concentration was measured using commercially available radioimmunoassay (RIA) in dogs with varying BCS. Spexin mRNA and protein expression were detected using real-time quantitative polymerase chain reaction and immunofluorescence staining.
+
+ RESULTS: Serum SPX concentration was lower in dogs with BCS4 (8.56 +/- 2.86) and BCS5 (6.7 +/- 2.12) compared to BCS2 (11.96 +/- 2.23) and BCS3 (10.51 +/- 2.19; BCS2 vs BCS5, P < .001 and BCS2 vs BCS4, P = .005; BCS3 vs BCS5, P = .002). Spexin mRNA was detected in adipose tissue, liver and pancreas. Spexin protein was expressed in adipose tissue and liver but not in pancreas. There were negative correlations between SPX and serum concentration of insulin (P < .05); leptin (P < .01), triglycerides (P < .01), total cholesterol (P < .01), nonesterified fatty acids (P < .01), and fructosamine (P < .01). There was a positive correlation between SPX and serum concentration of adiponectin (P < .01).
+
+ CONCLUSIONS AND CLINICAL IMPORTANCE: Spexin could be involved in pathogenesis of obesity in dogs, and might be considered as a potential marker for obesity. Copyright © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Observational Study, Veterinary.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fjvim.16019
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kolodziejski&issn=0891-6640&title=Journal+of+Veterinary+Internal+Medicine&atitle=Serum+spexin+concentration%2C+body+condition+score+and+markers+of+obesity+in+dogs.&volume=35&issue=1&spage=397&epage=404&date=2021&doi=10.1111%2Fjvim.16019&pmid=33426749&sid=OVID:medline
+
+<991>
+Unique Identifier
+ 33421943
+Title
+ Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity.
+Source
+ EBioMedicine. 63:103198, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Olga L; van Diepen JA; Bobeldijk-Pastorova I; Gross G; Prentice PM; Snowden SG; Furse S; Kooistra T; Hughes IA; Schoemaker MH; van Tol EAF; van Duyvenvoorde W; Wielinga PY; Ong KK; Dunger DB; Kleemann R; Koulman A
+Authors Full Name
+ Olga, L; van Diepen, J A; Bobeldijk-Pastorova, I; Gross, G; Prentice, P M; Snowden, S G; Furse, S; Kooistra, T; Hughes, I A; Schoemaker, M H; van Tol, E A F; van Duyvenvoorde, W; Wielinga, P Y; Ong, K K; Dunger, D B; Kleemann, R; Koulman, A.
+Institution
+ Olga, L. Department of Paediatrics, University of Cambridge, Cambridge, UK.
+ van Diepen, J A. Mead Johnson Pediatric Nutrition Institute, Nijmegen, the Netherlands.
+ Bobeldijk-Pastorova, I. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
+ Gross, G. Mead Johnson Pediatric Nutrition Institute, Nijmegen, the Netherlands.
+ Prentice, P M. Department of Paediatrics, University of Cambridge, Cambridge, UK.
+ Snowden, S G. Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
+ Furse, S. Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
+ Kooistra, T. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
+ Hughes, I A. Department of Paediatrics, University of Cambridge, Cambridge, UK.
+ Schoemaker, M H. Mead Johnson Pediatric Nutrition Institute, Nijmegen, the Netherlands.
+ van Tol, E A F. Mead Johnson Pediatric Nutrition Institute, Nijmegen, the Netherlands; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
+ van Duyvenvoorde, W. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
+ Wielinga, P Y. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
+ Ong, K K. Department of Paediatrics, University of Cambridge, Cambridge, UK; MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK; Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories' or (IMS-MRL), University of Cambridge, Cambridge, UK.
+ Dunger, D B. Department of Paediatrics, University of Cambridge, Cambridge, UK; Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories' or (IMS-MRL), University of Cambridge, Cambridge, UK.
+ Kleemann, R. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.
+ Koulman, A. Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK; MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK; Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories' or (IMS-MRL), University of Cambridge, Cambridge, UK. Electronic address: ak675@medschl.cam.ac.uk.
+MeSH Subject Headings
+ Adiposity/ge [Genetics]
+ *Adiposity
+ Animals
+ *Biomarkers
+ Delta-5 Fatty Acid Desaturase
+ Diet, High-Fat
+ Fatty Acid Desaturases/ge [Genetics]
+ *Fatty Acid Desaturases/me [Metabolism]
+ Humans
+ *Lipid Metabolism
+ Lipidomics/mt [Methods]
+ Male
+ Mice
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Stearoyl-CoA Desaturase/ge [Genetics]
+ *Stearoyl-CoA Desaturase/me [Metabolism]
+Keyword Heading
+ Adiposity
+ Desaturase
+ FADS
+ Infant growth
+ Lipid ratio
+ SCD1
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Altered lipid metabolism in early life has been associated with subsequent weight gain and predicting this could aid in obesity prevention and risk management. Here, a lipidomic approach was used to identify circulating markers for future obesity risk in translational murine models and validate in a human infant cohort.
+
+ METHODS: Lipidomics was performed on the plasma of APOE*3 Leiden, Ldlr-/-.Leiden, and the wild-type C57BL/6J mice to capture candidate biomarkers predicting subsequent obesity parameters after exposure to high-fat diet. The identified candidate biomarkers were mapped onto corresponding lipid metabolism pathways and were investigated in the Cambridge Baby Growth Study. Infants' growth and adiposity were measured at 0-24 months. Capillary dried blood spots were sampled at 3 months for lipid profiling analysis.
+
+ FINDINGS: From the mouse models, cholesteryl esters were correlated with subsequent weight gain and other obesity parameters after HFD period (Spearman's r>=0.5, FDR p values <0.05) among APOE*3 Leiden and Ldlr-/-.Leiden mice, but not among the wild-type C57BL/6J. Pathway analysis showed that those identified cholesteryl esters were educts or products of desaturases activities: stearoyl-CoA desaturase-1 (SCD1) and fatty acid desaturase (FADS) 1 and 2. In the human cohort, lipid ratios affected by SCD1 at 3 months was inversely associated with 3-12 months weight gain (B+/-SE=-0.31+/-0.14, p=0.027), but positively with 12-24 months weight and adiposity gains (0.17+/-0.07, p=0.02 and 0.17+/-0.07, 0.53+/-0.26, p=0.04, respectively). Lipid ratios affected by SCD1 and FADS2 were inversely associated with adiposity gain but positively with height gain between 3-12 months.
+
+ INTERPRETATION: From murine models to human setting, the ratios of circulating lipid species indicating key desaturase activities in lipid metabolism were associated with subsequent body size increase, providing a potential tool to predict early life weight gain. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Delta-5 Fatty Acid Desaturase). EC 1-14-19 (Fatty Acid Desaturases). EC 1-14-19-1 (Scd1 protein, mouse). EC 1-14-19-1 (Stearoyl-CoA Desaturase). EC 1-14-19-3 (FADS1 protein, human). EC 1-14-19-3 (FADS1 protein, mouse). EC 1-14-19-3 (FADS2 protein, mouse).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.ebiom.2020.103198
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Olga&issn=2352-3964&title=EBioMedicine&atitle=Lipid+ratios+representing+SCD1%2C+FADS1%2C+and+FADS2+activities+as+candidate+biomarkers+of+early+growth+and+adiposity.&volume=63&issue=&spage=103198&epage=&date=2021&doi=10.1016%2Fj.ebiom.2020.103198&pmid=33421943&sid=OVID:medline
+
+<992>
+Unique Identifier
+ 33420472
+Title
+ Effect of a nut-enriched low-calorie diet on body weight and selected markers of inflammation in overweight and obese stable coronary artery disease patients: a randomized controlled study.
+Source
+ European Journal of Clinical Nutrition. 75(7):1099-1108, 2021 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ghanavati M; Hosseinabadi SM; Parsa SA; Safi M; Emamat H; Nasrollahzadeh J
+Author NameID
+ Nasrollahzadeh, Javad; ORCID: http://orcid.org/0000-0002-9133-1870
+Authors Full Name
+ Ghanavati, Matin; Hosseinabadi, Susan Mohammadi; Parsa, Saeed Alipour; Safi, Morteza; Emamat, Hadi; Nasrollahzadeh, Javad.
+Institution
+ Ghanavati, Matin. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Hosseinabadi, Susan Mohammadi. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Parsa, Saeed Alipour. Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Safi, Morteza. Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Emamat, Hadi. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Nasrollahzadeh, Javad. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. jnasrollahzadeh@gmail.com.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Body Weight
+ Caloric Restriction
+ *Coronary Artery Disease
+ Female
+ Humans
+ Inflammation
+ Male
+ *Nuts
+ Obesity
+ Overweight
+Abstract
+ BACKGROUND/OBJECTIVES: Weight loss through a low-calorie diet (LCD) could improve low-grade inflammation evident in the obese state. Few studies have evaluated the effect of the mixed nuts consumption in the context of a LCD on inflammatory biomarkers. This study compared the effects of a nut-enriched LCD (NELCD) with a nut-free LCD (NFLCD) on body weight and inflammatory markers in overweight or obese coronary artery disease (CAD) patients.
+
+ SUBJECTS/METHOD: In this randomized controlled parallel trial, patients with stable CAD of both genders were randomly allocated to 8-week NELCD or NFLCD. Body weight, plasma C-reactive protein (CRP), interleukin-6 (IL-6), interleukin 10 (IL-10), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein (MCP-1) were assessed at baseline and 8 weeks.
+
+ RESULTS: Overall, 67 patients (aged 58.8 +/- 7.4 years; BMI 30.9 +/- 3.9 kg/m2) completed the study. Participants in both groups lost weight to a comparable extent. Patients in the NELCD group showed a decrease in ICAM-1 (p = 0.04) and IL-6 (p = 0.02) concentrations compared to NFLCD group. No significant difference in concentrations of MCP-1, IL-10, or CRP was observed between diet groups.
+
+ CONCLUSIONS: Nuts are healthy energy-dense foods that if included in controlled amounts in a weight management program can still result in weight reduction and may improve some plasma concentration of inflammatory factors, such as ICAM-1 and IL-6.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41430-020-00819-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ghanavati&issn=0954-3007&title=European+Journal+of+Clinical+Nutrition&atitle=Effect+of+a+nut-enriched+low-calorie+diet+on+body+weight+and+selected+markers+of+inflammation+in+overweight+and+obese+stable+coronary+artery+disease+patients%3A+a+randomized+controlled+study.&volume=75&issue=7&spage=1099&epage=1108&date=2021&doi=10.1038%2Fs41430-020-00819-9&pmid=33420472&sid=OVID:medline
+
+<993>
+Unique Identifier
+ 33413314
+Title
+ The association between parity and metabolic syndrome and its components in normal-weight postmenopausal women in China.
+Source
+ BMC Endocrine Disorders. 21(1):8, 2021 Jan 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shi M; Zhou X; Zheng C; Pan Y
+Author NameID
+ Pan, Youjin; ORCID: http://orcid.org/0000-0002-6361-2413
+Authors Full Name
+ Shi, Mengte; Zhou, Xinhe; Zheng, Chao; Pan, Youjin.
+Institution
+ Shi, Mengte. Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, 325000, China.
+ Zhou, Xinhe. Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, 325000, China.
+ Zheng, Chao. Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, 325000, China. zhengchao_1010@126.com.
+ Zheng, Chao. The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China. zhengchao_1010@126.com.
+ Pan, Youjin. Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, 325000, China. 526623800@qq.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Parity
+ *Postmenopause
+ Pregnancy
+ Prevalence
+ Prognosis
+ Risk Factors
+ *Waist Circumference
+Keyword Heading
+ Metabolic syndrome
+ Normal weight
+ Parity
+ Postmenopausal
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Studies analyzing the association between parity and normal-weight metabolic syndrome (MetS) in postmenopausal women of normal weight remain limited, this study aimed to explore the association between parity and MetS among Chinese normal-weight postmenopausal women.
+
+ METHODS: In total, 776 normal-weight undiagnosed type 2 diabetes postmenopausal women who visited the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University for a routine health check-up between 1 January 2017 and 31 December 2019 were included in the cross-sectional study. All individuals had fully completed information records encompassing standardized electronic medical records, physical examinations, and biochemical measurements. Metabolic health was defined as fewer than 2 parameters of the MetS were present, in combination with normal weight. Continuous variables which were normally distributed were expressed as means and standard deviation. Comparisons among normally distributed continuous variables were made using one-way ANOVA while that among non-normal distribution parameters were made using Kruskal-Wallis. The association between parity and MetS was analyzed using multivariate logistic regression. All of the analyses were performed with SPSS statistical software (Version 23.0, SPSS, Inc., Chicago, IL, USA) and the statistical software package EmpowerStats ( http://www.empowerstats.com , X&Y Solutions, Inc., Boston, MA).
+
+ RESULTS: After adjusting for potential confounding factors including hip circumference, parity was failed to show a significantly relationship with MetS in normal-weight women(P=0.054). Women with a higher parity (>=3) had an increased OR of abdominal obesity, while the OR (95% CI) of the parity 3 group was 2.06 (1.13, 3.77) and that of the parity >=4 group was 3.08(1.42, 6.66) the P for trend was 0.002 after adjusting for potential confounding factors. No significant differences were detected for other metabolic disorders including high levels of triglycerides (TG), blood pressure, fasting plasma glucose (FPG), and decreased high-density lipoprotein cholesterol (HDL-C) in different parity groups.
+
+ CONCLUSIONS: Higher parity was not associated with a higher risk of MetS in normal weight Chinese postmenopausal women. As for the components of MetS, only waist circumference was associated with multiparity even after controlling for hip circumference.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1186%2fs12902-020-00674-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shi&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=The+association+between+parity+and+metabolic+syndrome+and+its+components+in+normal-weight+postmenopausal+women+in+China.&volume=21&issue=1&spage=8&epage=&date=2021&doi=10.1186%2Fs12902-020-00674-6&pmid=33413314&sid=OVID:medline
+
+<994>
+Unique Identifier
+ 33413091
+Title
+ The prevalence of hypercholesterolemia and associated risk factors in Al-Kharj population, Saudi Arabia: a cross-sectional survey.
+Source
+ BMC Cardiovascular Disorders. 21(1):22, 2021 01 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Zahrani J; Shubair MM; Al-Ghamdi S; Alrasheed AA; Alduraywish AA; Alreshidi FS; Alshahrani SM; Alsalamah M; Al-Khateeb BF; Ashathri AI; El-Metwally A; Aldossari KK
+Author NameID
+ Shubair, Mamdouh M; ORCID: https://orcid.org/0000-0003-4758-072X
+ Al-Ghamdi, Sameer; ORCID: https://orcid.org/0000-0003-0506-0574
+ Alshahrani, Saeed Mastour; ORCID: https://orcid.org/0000-0003-2714-7785
+ Al-Khateeb, Badr F; ORCID: https://orcid.org/0000-0001-9824-7148
+ El-Metwally, Ashraf; ORCID: https://orcid.org/0000-0001-5575-0077
+ Aldossari, Khaled K; ORCID: https://orcid.org/0000-0003-3265-8651
+Authors Full Name
+ Al-Zahrani, Jamaan; Shubair, Mamdouh M; Al-Ghamdi, Sameer; Alrasheed, Abdullah A; Alduraywish, Abdulrahman A; Alreshidi, Fayez Saud; Alshahrani, Saeed Mastour; Alsalamah, Majid; Al-Khateeb, Badr F; Ashathri, Aljawharah Ibraheem; El-Metwally, Ashraf; Aldossari, Khaled K.
+Institution
+ Al-Zahrani, Jamaan. Family and Community Medicine Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia. jamaan.alzahrani@outlook.com.
+ Shubair, Mamdouh M. School of Health Sciences, University of Northern British Columbia (UNBC), 3333 University Way, Prince George, BC, V2N 4Z9, Canada.
+ Al-Ghamdi, Sameer. Family and Community Medicine Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
+ Alrasheed, Abdullah A. Family and Community Medicine Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
+ Alduraywish, Abdulrahman A. Internal Medicine Department, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
+ Alreshidi, Fayez Saud. Family and Community Medicine Department, College of Medicine, University of Hail, Hail, Saudi Arabia.
+ Alshahrani, Saeed Mastour. College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
+ Alsalamah, Majid. Department of Emergency Medicine, King Abdulaziz Medical City, College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
+ Al-Khateeb, Badr F. Department of Family Medicine, King Abdulaziz Medical City, College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
+ Ashathri, Aljawharah Ibraheem. Clinical Nutrition, Community Health Department, Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
+ El-Metwally, Ashraf. College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
+ Aldossari, Khaled K. Family and Community Medicine Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Cholesterol/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ Health Surveys
+ Humans
+ Hypercholesterolemia/bl [Blood]
+ Hypercholesterolemia/di [Diagnosis]
+ *Hypercholesterolemia/ep [Epidemiology]
+ Job Description
+ Male
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Occupations
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Saudi Arabia/ep [Epidemiology]
+ Sex Factors
+ Unemployment
+ Young Adult
+Keyword Heading
+ Al-kharj
+ Cross-sectional
+ Hypercholesterolemia
+ Obesity
+ Saudi arabia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hypercholesterolemia (HC) is an important precursor to many cardiovascular, cerebrovascular, and peripheral vascular diseases. A report conducted by the American Heart Association showed the prevalence of HC to be 11.9%, with around 28.5 million adults age >= 20 years having high cholesterol levels. This study aimed to evaluate the prevalence of HC and its associated risk factors among the general population of Al-Kharj, Saudi Arabia.
+
+ METHOD: A cross-sectional study was conducted on the general population of Al-Kharj, Saudi Arabia in 2016. The representative sample consisted of 1019 individuals, who all participated on a voluntary basis. The statistical analysis was performed using SPSS version 25.
+
+ RESULTS: The results of this study showed the prevalence of HC in the sample to be 12.5%. There was a significant moderate positive association between increasing age and the prevalence of HC (r = 0.240, P < 0.0001). Males had a significantly higher prevalence of HC (56.7%) compared to their female counterparts (43.3%) (X2 = 23.093, P <= 0.0001). BMI was positively and significantly associated with high cholesterol status. Participants in the overweight category had a significantly higher risk of HC (OR = 1.727; 95% CI = 1.58-1.914; P = 0.046). The non-obese (< 25 kg/m2) participants had an inverse significant association with the risk of hypercholesterolemia. (OR = 0.411; 95% CI = 0.216-0.783; P = 0.007).
+
+ CONCLUSION: In this population-based study, the predominant risk factors of HC in Al-Kharj region were being of a Saudi nationality, male, having obesity, being unemployed, and being a civilian worker. There is a clear need for future screening studies of HC, as most previous studies have reported contradictory prevalence data (because they were conducted in different regions of KSA). Furthermore, well-designed prospective cohort studies are needed in the future to assess how the association between lifestyle behavioural factors such as dietary intake patterns and levels of physical activity may affect the relative risk of HC status.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1186%2fs12872-020-01825-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Zahrani&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=The+prevalence+of+hypercholesterolemia+and+associated+risk+factors+in+Al-Kharj+population%2C+Saudi+Arabia%3A+a+cross-sectional+survey.&volume=21&issue=1&spage=22&epage=&date=2021&doi=10.1186%2Fs12872-020-01825-2&pmid=33413091&sid=OVID:medline
+
+<995>
+Unique Identifier
+ 33400176
+Title
+ Waist-to-height ratio and BMI as predictive markers for insulin resistance in women with PCOS in Kolkata, India.
+Source
+ Endocrine. 72(1):86-95, 2021 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bhattacharya K; Sengupta P; Dutta S; Chaudhuri P; Das Mukhopadhyay L; Syamal AK
+Authors Full Name
+ Bhattacharya, Koushik; Sengupta, Pallav; Dutta, Sulagna; Chaudhuri, Prasenjit; Das Mukhopadhyay, Lipika; Syamal, Alak Kumar.
+Institution
+ Bhattacharya, Koushik. Post Graduate Department of Physiology, Hooghly Mohsin College, University of Burdwan, Bardhaman, West Bengal, India.
+ Bhattacharya, Koushik. Department of Physiology, Rungta College of Dental Sciences and Research, Bhilai, Chhattisgarh, India.
+ Sengupta, Pallav. Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor, Malaysia.
+ Dutta, Sulagna. Faculty of Dentistry, MAHSA University, Jenjarom, Selangor, Malaysia.
+ Chaudhuri, Prasenjit. Department of Physiology, Government General Degree College, Paschim Medinipur, West Bengal, India.
+ Das Mukhopadhyay, Lipika. Department of Obstetrics and Gynecology, KPC Medical College, Jadavpur, Kolkata, West Bengal, India. drlipikamukhopadhyay@yahoo.in.
+ Syamal, Alak Kumar. Post Graduate Department of Physiology, Hooghly Mohsin College, University of Burdwan, Bardhaman, West Bengal, India. alaksyamal@gmail.com.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Humans
+ India/ep [Epidemiology]
+ *Insulin Resistance
+ Obesity
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ Polycystic Ovary Syndrome/ep [Epidemiology]
+ *Polycystic Ovary Syndrome
+Keyword Heading
+ BMI
+ Insulin resistance
+ Obesity
+ PCOS
+ WHR
+ WHtR
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Polycystic ovarian syndrome (PCOS) is most commonly presented with insulin resistance (IR). Simple anthropometric indices may serve as surrogate markers of these conditions with population-based cut-off values. The present study suggests the cut-off values of waist-to-height ratio (WHtR) and body mass index (BMI) in early prediction of PCOS and IR in PCOS women based in Kolkata, a major metropolitan city in India.
+
+ METHODS: This cross-sectional study included 66 women (aged 16-30 years) from Kolkata, India, with confirmed PCOS, using Rotterdam criteria. IR was defined following the homeostasis model assessment (HOMA). Anthropometric and biochemical data were obtained using standard protocol and compared among the PCOS subjects grouped as per IR prevalence, BMI, and WHtR values. The receiver operating characteristics (ROC) curve was applied to evaluate and compare the cut-off values of WHtR and BMI in the prediction of PCOS and IR in women with PCOS.
+
+ RESULTS: As per ROC analysis, WHtR showed significantly higher AUC in the detection of PCOS and IR in PCOS subjects respectively, than that of BMI. The cut-off values of WHtR and BMI for PCOS were 0.560 and 28.47 respectively, and for IR in PCOS patients, were 0.620 and 29.14 respectively.
+
+ CONCLUSIONS: The present study suggests a cut-off value of WHtR to be used as an inexpensive and noninvasive screening tool for early prediction of PCOS and IR among PCOS afflicted women based in Kolkata, India and for this prediction, the study also claims WHtR as a better index than BMI.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs12020-020-02555-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bhattacharya&issn=1355-008X&title=Endocrine&atitle=Waist-to-height+ratio+and+BMI+as+predictive+markers+for+insulin+resistance+in+women+with+PCOS+in+Kolkata%2C+India.&volume=72&issue=1&spage=86&epage=95&date=2021&doi=10.1007%2Fs12020-020-02555-3&pmid=33400176&sid=OVID:medline
+
+<996>
+Unique Identifier
+ 33390322
+Title
+ The role of obesity in inflammatory markers in COVID-19 patients.
+Source
+ Obesity Research & Clinical Practice. 15(1):96-99, 2021 Jan-Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ McNeill JN; Lau ES; Paniagua SM; Liu EE; Wang JK; Bassett IV; Selvaggi CA; Lubitz SA; Foulkes AS; Ho JE
+Authors Full Name
+ McNeill, Jenna N; Lau, Emily S; Paniagua, Samantha M; Liu, Elizabeth E; Wang, Jessica K; Bassett, Ingrid V; Selvaggi, Caitlin A; Lubitz, Steven A; Foulkes, Andrea S; Ho, Jennifer E.
+Institution
+ McNeill, Jenna N. The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States; Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, United States.
+ Lau, Emily S. The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States; Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
+ Paniagua, Samantha M. The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States.
+ Liu, Elizabeth E. The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States.
+ Wang, Jessica K. The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States.
+ Bassett, Ingrid V. Division Infectious Disease, Massachusetts General Hospital, Boston, MA, United States; Mongan Institute, Massachusetts General Hospital, Boston, MA, United States.
+ Selvaggi, Caitlin A. The Biostatistics Center, Massachusetts General Hospital, Boston, MA, United States.
+ Lubitz, Steven A. Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
+ Foulkes, Andrea S. The Biostatistics Center, Massachusetts General Hospital, Boston, MA, United States.
+ Ho, Jennifer E. The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States; Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States. Electronic address: jho1@mgh.harvard.edu.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ *Blood Sedimentation
+ Body Mass Index
+ *C-Reactive Protein/me [Metabolism]
+ *COVID-19/bl [Blood]
+ COVID-19/co [Complications]
+ Female
+ *Fibrin Fibrinogen Degradation Products/me [Metabolism]
+ Hospital Mortality
+ Hospitalization
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/et [Etiology]
+ Male
+ Massachusetts/ep [Epidemiology]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Odds Ratio
+ Respiratory Insufficiency/bl [Blood]
+ Respiratory Insufficiency/et [Etiology]
+ Risk Factors
+ SARS-CoV-2
+ *Severity of Illness Index
+Keyword Heading
+ COVID-19
+ CRP
+ D-dimer
+ ESR
+ Inflammation
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity has emerged as a significant risk factor for severe COVID-19 worldwide. Given both COVID-19 infection and obesity have been associated with increased systemic inflammation, we evaluated inflammatory markers in obese and non-obese individuals hospitalized for COVID-19 at Massachusetts General Hospital. We hypothesized that obese patients would have a more exuberant inflammatory response as evidenced by higher initial and peak inflammatory markers along with worse clinical outcomes. Of the 781 patients, 349 were obese (45%). Obese individuals had higher initial and peak levels of CRP and ESR as well as higher peak d-dimer (P < 0.01 for all) in comparison to non-obese individuals, while. IL-6 and ferritin were similar. In addition, obese individuals had a higher odds of requiring vasopressor use (OR 1.54, 95% CI 1.00-2.38, P = 0.05), developing hypoxemic respiratory failure (OR 1.58, 95% CI 1.04-2.40, P = 0.03) and death (OR 2.20, 95% CI 1.31-3.70, P = 0.003) within 28 days of presentation to care. Finally, higher baseline levels of CRP and D-dimer were associated with worse clinical outcomes even after adjustment for BMI. Our findings suggest greater disease severity in obese individuals is characterized by more exuberant inflammation. Copyright © 2020 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fibrin Fibrinogen Degradation Products). 0 (fibrin fragment D). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.orcp.2020.12.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=McNeill&issn=1871-403X&title=Obesity+Research+%26+Clinical+Practice&atitle=The+role+of+obesity+in+inflammatory+markers+in+COVID-19+patients.&volume=15&issue=1&spage=96&epage=99&date=2021&doi=10.1016%2Fj.orcp.2020.12.004&pmid=33390322&sid=OVID:medline
+
+<997>
+Unique Identifier
+ 33388039
+Title
+ Association between insulin resistance and left ventricular hypertrophy in asymptomatic, Black, sub-Saharan African, hypertensive patients: a case-control study.
+Source
+ BMC Cardiovascular Disorders. 21(1):1, 2021 01 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kianu Phanzu B; Nkodila Natuhoyila A; Kintoki Vita E; M'Buyamba Kabangu JR; Longo-Mbenza B
+Author NameID
+ Kianu Phanzu, Bernard; ORCID: https://orcid.org/0000-0001-9836-9532
+Authors Full Name
+ Kianu Phanzu, Bernard; Nkodila Natuhoyila, Aliocha; Kintoki Vita, Eleuthere; M'Buyamba Kabangu, Jean-Rene; Longo-Mbenza, Benjamin.
+Institution
+ Kianu Phanzu, Bernard. Cardiology Unit, University Hospital of Kinshasa, PO Box 1038, Kinshasa, Democratic Republic of Congo. doctorkianu@gmail.com.
+ Kianu Phanzu, Bernard. Centre Medical de Kinshasa (CMK), Kinshasa, Democratic Republic of Congo. doctorkianu@gmail.com.
+ Nkodila Natuhoyila, Aliocha. Department of Biostatistics, Public Health School, Kinshasa, Democratic Republic of Congo.
+ Kintoki Vita, Eleuthere. Cardiology Unit, University Hospital of Kinshasa, PO Box 1038, Kinshasa, Democratic Republic of Congo.
+ M'Buyamba Kabangu, Jean-Rene. Cardiology Unit, University Hospital of Kinshasa, PO Box 1038, Kinshasa, Democratic Republic of Congo.
+ Longo-Mbenza, Benjamin. Cardiology Unit, University Hospital of Kinshasa, PO Box 1038, Kinshasa, Democratic Republic of Congo.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Black People
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Case-Control Studies
+ Democratic Republic of the Congo/eh [Ethnology]
+ Essential Hypertension/di [Diagnosis]
+ *Essential Hypertension/eh [Ethnology]
+ Essential Hypertension/pp [Physiopathology]
+ Female
+ Humans
+ Hypertrophy, Left Ventricular/dg [Diagnostic Imaging]
+ *Hypertrophy, Left Ventricular/eh [Ethnology]
+ Hypertrophy, Left Ventricular/pp [Physiopathology]
+ Insulin/bl [Blood]
+ *Insulin Resistance/eh [Ethnology]
+ Male
+ Middle Aged
+ Obesity/eh [Ethnology]
+ Risk Assessment
+ Risk Factors
+ Ventricular Function, Left
+ Ventricular Remodeling
+Keyword Heading
+ Black
+ Hyperinsulinemia
+ Hypertension
+ Insulin resistance
+ Left ventricular hypertrophy
+ Left ventricular mass
+ Obesity
+ Sedentary time
+ Sub-saharan african
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Conflicting information exists regarding the association between insulin resistance (IR) and left ventricular hypertrophy (LVH). We described the associations between obesity, fasting insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), and LVH in Black patients with essential hypertension.
+
+ METHODS: A case-control study was conducted at the Centre Medical de Kinshasa (CMK), the Democratic Republic of the Congo, between January and December 2019. Cases and controls were hypertensive patients with and without LVH, respectively. The relationships between obesity indices, physical inactivity, glucose metabolism and lipid disorder parameters, and LVH were assessed using linear and logistic regression analyses in simple and univariate exploratory analyses, respectively. When differences were observed between LVH and independent variables, the effects of potential confounders were studied through the use of multiple linear regression and in conditional logistic regression in multivariate analyses. The coefficients of determination (R2), adjusted odds ratios (aORs), and their 95% confidence intervals (95% CIs) were calculated to determine associations between LVH and the independent variables.
+
+ RESULTS: Eighty-eight LVH cases (52 men) were compared against 132 controls (81 men). Variation in left ventricular mass (LVM) could be predicted by the following variables: age (19%), duration of hypertension (31.3%), body mass index (BMI, 44.4%), waist circumference (WC, 42.5%), glycemia (20%), insulinemia (44.8%), and HOMA-IR (43.7%). Hypertension duration, BMI, insulinemia, and HOMA-IR explained 68.3% of LVM variability in the multiple linear regression analysis. In the logistic regression model, obesity increased the risk of LVH by threefold [aOR 2.8; 95% CI (1.06-7.4); p = 0.038], and IR increased the risk of LVH by eightfold [aOR 8.4; 95 (3.7-15.7); p < 0.001].
+
+ CONCLUSION: Obesity and IR appear to be the primary predictors of LVH in Black sub-Saharan African hypertensive patients. The comprehensive management of cardiovascular risk factors should be emphasized, with particular attention paid to obesity and IR. A prospective population-based study of Black sub-Saharan individuals that includes the use of serial imaging remains essential to better understand subclinical LV deterioration over time and to confirm the role played by IR in Black sub-Saharan individuals with hypertension.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1186%2fs12872-020-01829-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kianu+Phanzu&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Association+between+insulin+resistance+and+left+ventricular+hypertrophy+in+asymptomatic%2C+Black%2C+sub-Saharan+African%2C+hypertensive+patients%3A+a+case-control+study.&volume=21&issue=1&spage=1&epage=&date=2021&doi=10.1186%2Fs12872-020-01829-y&pmid=33388039&sid=OVID:medline
+
+<998>
+Unique Identifier
+ 33380172
+Title
+ Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health.
+Source
+ Arteriosclerosis, Thrombosis & Vascular Biology. 41(2):883-897, 2021 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pauls SD; Du Y; Clair L; Winter T; Aukema HM; Taylor CG; Zahradka P
+Authors Full Name
+ Pauls, Samantha D; Du, Youjia; Clair, Luc; Winter, Tanja; Aukema, Harold M; Taylor, Carla G; Zahradka, Peter.
+Institution
+ Pauls, Samantha D. Department of Food and Human Nutritional Sciences (S.D.P., T.W., H.M.A., C.G.T., P.Z.), University of Manitoba, Canada.
+ Pauls, Samantha D. Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, Canada (S.D.P., Y.D., L.C., T.W., H.M.A., C.G.T., P.Z.).
+ Du, Youjia. Department of Physiology and Pathophysiology (Y.D., C.G.T., P.Z.), University of Manitoba, Canada.
+ Du, Youjia. Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, Canada (S.D.P., Y.D., L.C., T.W., H.M.A., C.G.T., P.Z.).
+ Clair, Luc. Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, Canada (S.D.P., Y.D., L.C., T.W., H.M.A., C.G.T., P.Z.).
+ Clair, Luc. Department of Economics, University of Winnipeg, Canada (L.C.).
+ Winter, Tanja. Department of Food and Human Nutritional Sciences (S.D.P., T.W., H.M.A., C.G.T., P.Z.), University of Manitoba, Canada.
+ Winter, Tanja. Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, Canada (S.D.P., Y.D., L.C., T.W., H.M.A., C.G.T., P.Z.).
+ Aukema, Harold M. Department of Food and Human Nutritional Sciences (S.D.P., T.W., H.M.A., C.G.T., P.Z.), University of Manitoba, Canada.
+ Aukema, Harold M. Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, Canada (S.D.P., Y.D., L.C., T.W., H.M.A., C.G.T., P.Z.).
+ Taylor, Carla G. Department of Food and Human Nutritional Sciences (S.D.P., T.W., H.M.A., C.G.T., P.Z.), University of Manitoba, Canada.
+ Taylor, Carla G. Department of Physiology and Pathophysiology (Y.D., C.G.T., P.Z.), University of Manitoba, Canada.
+ Taylor, Carla G. Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, Canada (S.D.P., Y.D., L.C., T.W., H.M.A., C.G.T., P.Z.).
+ Zahradka, Peter. Department of Food and Human Nutritional Sciences (S.D.P., T.W., H.M.A., C.G.T., P.Z.), University of Manitoba, Canada.
+ Zahradka, Peter. Department of Physiology and Pathophysiology (Y.D., C.G.T., P.Z.), University of Manitoba, Canada.
+ Zahradka, Peter. Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, Canada (S.D.P., Y.D., L.C., T.W., H.M.A., C.G.T., P.Z.).
+MeSH Subject Headings
+ 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid/bl [Blood]
+ Adult
+ Age Factors
+ Aged
+ Ankle Brachial Index
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ Docosahexaenoic Acids/bl [Blood]
+ Eicosapentaenoic Acid/aa [Analogs & Derivatives]
+ Eicosapentaenoic Acid/bl [Blood]
+ Female
+ *Health Status Disparities
+ Heart Disease Risk Factors
+ Humans
+ Male
+ *Menopause/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Oxylipins/bl [Blood]
+ Pulse Wave Analysis
+ Risk Assessment
+ Sex Factors
+ Up-Regulation
+ Vascular Stiffness
+ Young Adult
+Keyword Heading
+ cardiovascular disease
+ lipoxygenase
+ menopause
+ obesity
+ oxylipins
+ risk factor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Cardiovascular disease, a major cause of mortality and morbidity, exhibits sexual dimorphism since the onset of cardiovascular disease occurs later in women than in men. The loss of cardioprotection in older women may be due to an increase in arterial stiffness after menopause. Free fatty acid metabolites of polyunsaturated fatty acids, called oxylipins, are known to impact vessel function and may be responsible for the vascular benefits of polyunsaturated fatty acids. The objectives of this study were to compare the plasma oxylipin profiles of young females (20-55 years), older females (55+), and older males (55+) and to identify associations between oxylipins and cardiovascular disease risk factors, such as obesity and arterial stiffness. Approach and Results: We quantified plasma oxylipins by high-performance liquid chromatography-tandem mass spectrometry in archived samples taken from completed clinical trials. We identified 3 major 12-lipoxygenase products, 12-hydroxy-eicosatetraenoic acid, 12-hydroxy-eicosapentaenoic acid, and 14-hydroxy-docosahexaenoic acid, that are present at high levels in young females compared with older females and males. These oxylipins also decreased with obesity and displayed robust negative associations with arterial stiffness as assessed by brachial-ankle pulse wave velocity. According to multiple linear regression modeling, these associations were maintained even after correcting for body mass index category combined with either age, menopausal status, or estradiol levels. Using linear discriminant analysis, the combination of these 3 oxylipins effectively distinguished participants according to both brachial-ankle pulse wave velocity risk group and age.
+
+ CONCLUSIONS: Higher 12-lipoxygenase oxylipin plasma concentrations associated with lower arterial stiffness in premenopausal females may be an important contributing factor to sex differences in cardiovascular disease. Registration: URL: https://www.clinicaltrials.gov; Unique identifiers: NCT01661543, NCT01562171, NCT01890330, NCT02571114 and NCT02317588.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Oxylipins). 25167-62-8 (Docosahexaenoic Acids). 59985-28-3 (12-Hydroxy-5,8,10,14-eicosatetraenoic Acid). 74838-73-6 (12-hydroxy-5,8,10,14,17-eicospentaenoic acid). 86360-66-9 (14-hydroxydocosahexaenoic acid). AAN7QOV9EA (Eicosapentaenoic Acid).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1161%2fATVBAHA.120.315133
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pauls&issn=1079-5642&title=Arteriosclerosis%2C+Thrombosis+%26+Vascular+Biology&atitle=Impact+of+Age%2C+Menopause%2C+and+Obesity+on+Oxylipins+Linked+to+Vascular+Health.&volume=41&issue=2&spage=883&epage=897&date=2021&doi=10.1161%2FATVBAHA.120.315133&pmid=33380172&sid=OVID:medline
+
+<999>
+Unique Identifier
+ 33372524
+Title
+ Relationship of Circulating Endothelial Cells With Obesity and Cardiometabolic Risk Factors in Children and Adolescents.
+Source
+ Journal of the American Heart Association. 10(1):e018092, 2021 01 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Soltero EG; Solovey AN; Hebbel RP; Palzer EF; Ryder JR; Shaibi GQ; Olson M; Fox CK; Rudser KD; Dengel DR; Evanoff NG; Kelly AS
+Authors Full Name
+ Soltero, Erica G; Solovey, Anna N; Hebbel, Robert P; Palzer, Elise F; Ryder, Justin R; Shaibi, Gabriel Q; Olson, Micah; Fox, Claudia K; Rudser, Kyle D; Dengel, Donald R; Evanoff, Nicholas G; Kelly, Aaron S.
+Institution
+ Soltero, Erica G. Department of Pediatrics Children's Nutrition Research CenterBaylor College of Medicine Houston TX.
+ Solovey, Anna N. Vascular Biology Center Division of Hematology Oncology & Transplantation University of Minnesota Medical School Minneapolis MN.
+ Hebbel, Robert P. Vascular Biology Center Division of Hematology Oncology & Transplantation University of Minnesota Medical School Minneapolis MN.
+ Hebbel, Robert P. Department of Medicine University of Minnesota Medical School Minneapolis MN.
+ Palzer, Elise F. Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN.
+ Ryder, Justin R. Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN.
+ Ryder, Justin R. Department of Pediatrics University of Minnesota Medical School Minneapolis MN.
+ Shaibi, Gabriel Q. Center for Health Promotion and Disease Prevention Arizona State University Phoenix AZ.
+ Shaibi, Gabriel Q. Department of Pediatric Endocrinology and Diabetes Phoenix Children's Hospital Phoenix AZ.
+ Olson, Micah. Center for Health Promotion and Disease Prevention Arizona State University Phoenix AZ.
+ Olson, Micah. Department of Pediatric Endocrinology and Diabetes Phoenix Children's Hospital Phoenix AZ.
+ Fox, Claudia K. Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN.
+ Fox, Claudia K. Department of Pediatrics University of Minnesota Medical School Minneapolis MN.
+ Rudser, Kyle D. Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN.
+ Rudser, Kyle D. Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN.
+ Dengel, Donald R. Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN.
+ Dengel, Donald R. Department of Pediatrics University of Minnesota Medical School Minneapolis MN.
+ Dengel, Donald R. School of Kinesiology University of Minnesota Minneapolis MN.
+ Evanoff, Nicholas G. Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN.
+ Evanoff, Nicholas G. School of Kinesiology University of Minnesota Minneapolis MN.
+ Kelly, Aaron S. Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN.
+ Kelly, Aaron S. Department of Pediatrics University of Minnesota Medical School Minneapolis MN.
+MeSH Subject Headings
+ Adiposity/ph [Physiology]
+ Adolescent
+ Age of Onset
+ Atherosclerosis/bl [Blood]
+ Atherosclerosis/di [Diagnosis]
+ Atherosclerosis/pp [Physiopathology]
+ *Atherosclerosis
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cardiometabolic Risk Factors
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/me [Metabolism]
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Cardiovascular Diseases
+ Child
+ Correlation of Data
+ *Endothelial Cells/me [Metabolism]
+ Female
+ Humans
+ Immunohistochemistry
+ Intra-Abdominal Fat/me [Metabolism]
+ Male
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity
+ United States/ep [Epidemiology]
+ *Vascular Cell Adhesion Molecule-1/bl [Blood]
+Keyword Heading
+ adolescents
+ cardiovascular risk
+ children
+ endothelial health
+ novel biomarkers
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Circulating endothelial cells (CECs) reflect early changes in endothelial health; however, the degree to which CEC number and activation is related to adiposity and cardiovascular risk factors in youth is not well described. Methods and Results Youth in this study (N=271; aged 8-20 years) were classified into normal weight (body mass index [BMI] percentage <85th; n=114), obesity (BMI percentage >=95th to <120% of the 95th; n=63), and severe obesity (BMI percentage >=120% of the 95th; n=94) catagories. CEC enumeration was determined using immunohistochemical examination of buffy coat smears and activated CEC (percentage of vascular cell adhesion molecule-1 expression) was assessed using immunofluorescent staining. Cardiovascular risk factors included measures of body composition, blood pressure, glucose, insulin, lipid profile, C-reactive protein, leptin, adiponectin, oxidized low-density lipoprotein cholesterol, carotid artery intima-media thickness, and pulse wave velocity. Linear regression models examined associations between CEC number and activation with BMI and cardiovascular risk factors. CEC number did not differ among BMI classes (P>0.05). Youth with severe obesity had a higher degree of CEC activation compared with normal weight youth (8.3%; 95% CI, 1.1-15.6 [P=0.024]). Higher CEC number was associated with greater body fat percentage (0.02 per percentage; 95% CI, 0.00-0.03 [P=0.020]) and systolic blood pressure percentile (0.01 per percentage; 95% CI, 0.00-0.01 [P=0.035]). Higher degree of CEC activation was associated with greater visceral adipose tissue (5.7% per kg; 95% CI, 0.4-10.9 [P=0.034]) and non-high-density lipoprotein cholesterol (0.11% per mg/dL; 95% CI, 0.01-0.21 [P=0.039]). Conclusions Methods of CEC quantification are associated with adiposity and cardiometabolic risk factors and may potentially reflect accelerated atherosclerosis as early as childhood.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Vascular Cell Adhesion Molecule-1).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1161%2fJAHA.120.018092
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Soltero&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Relationship+of+Circulating+Endothelial+Cells+With+Obesity+and+Cardiometabolic+Risk+Factors+in+Children+and+Adolescents.&volume=10&issue=1&spage=e018092&epage=&date=2021&doi=10.1161%2FJAHA.120.018092&pmid=33372524&sid=OVID:medline
+
+<1000>
+Unique Identifier
+ 33370629
+Title
+ Garcinia linii extracts exert the mediation of anti-diabetic molecular targets on anti-hyperglycemia.
+Source
+ Biomedicine & Pharmacotherapy. 134:111151, 2021 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen TH; Fu YS; Chen SP; Fuh YM; Chang C; Weng CF
+Authors Full Name
+ Chen, Ting-Hsu; Fu, Yaw-Syan; Chen, Sih-Pei; Fuh, Yuh-Ming; Chang, Charves; Weng, Ching-Feng.
+Institution
+ Chen, Ting-Hsu. Institute of Respiratory Disease, Department of Basic Medical Science, Xiamen Medical College, Xiamen, 361023, Fujian, China; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan.
+ Fu, Yaw-Syan. Institute of Respiratory Disease, Department of Basic Medical Science, Xiamen Medical College, Xiamen, 361023, Fujian, China.
+ Chen, Sih-Pei. Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan.
+ Fuh, Yuh-Ming. Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan.
+ Chang, Charves. Institute of Respiratory Disease, Department of Basic Medical Science, Xiamen Medical College, Xiamen, 361023, Fujian, China; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan.
+ Weng, Ching-Feng. Institute of Respiratory Disease, Department of Basic Medical Science, Xiamen Medical College, Xiamen, 361023, Fujian, China. Electronic address: cfweng-cfweng@hotmail.com.
+MeSH Subject Headings
+ 3T3 Cells
+ Adipocytes/de [Drug Effects]
+ Adipocytes/en [Enzymology]
+ Animals
+ Antioxidants/ip [Isolation & Purification]
+ *Antioxidants/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ Diabetes Mellitus/bl [Blood]
+ *Diabetes Mellitus/dt [Drug Therapy]
+ Diabetes Mellitus/en [Enzymology]
+ Diabetes Mellitus/et [Etiology]
+ Diet, High-Fat
+ Disease Models, Animal
+ Garcinia/ch [Chemistry]
+ *Garcinia
+ Glycoside Hydrolase Inhibitors/ip [Isolation & Purification]
+ *Glycoside Hydrolase Inhibitors/pd [Pharmacology]
+ Hepatocytes/de [Drug Effects]
+ Hepatocytes/en [Enzymology]
+ Male
+ Mice
+ Mice, Inbred ICR
+ Molecular Docking Simulation
+ Obesity/et [Etiology]
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ Plant Leaves
+ Plant Stems
+ *alpha-Amylases/ai [Antagonists & Inhibitors]
+ alpha-Amylases/me [Metabolism]
+ alpha-Glucosidases/me [Metabolism]
+Keyword Heading
+ Alpha-amylase
+ Alpha-glucosidase
+ Diabetes
+ Garcinia linii
+ Hypoglycemia
+ Syringaldehyde
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Different portions (stem GIS and leaf GIL) of Garcinia linii were extracted by ethanol/water and crude extracts were employed to investigate the contents of total phenol and flavonoids, antioxidation activities, and inhibitory activities of alpha-amylase and alpha-glucosidase via enzymatic assay and OGTT and OSTT for lowering glucose levels. The data revealed that GlS and GlL contained different levels of flavonoids and total phenol. Furthermore, the results showed the extracts exhibited remarkable antioxidation activities and inhibitory activities of alpha-amylase and alpha-glucosidase. In silico docking studies were done using Gold software and the probable molecules retrieved from PubChem were docked with several anti-diabetic relate targets, the results showed several components of G. linii could potentially inhibit diabetic molecules when compared with clinic drugs. The cell glucose uptake data also confirmed that GlL and GlS could retain the active component in the regulation of insulin, AMPK, PPARgamma, and DPP4. In vivo, the evidence showed G. linii extracts including syringaldehyde suppressed effect of hyperglycemia on OSTT and OGTT assays. These results suggest that G. linii extract has a potential therapeutic value for the treatment of diabetes in humans. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycoside Hydrolase Inhibitors). 0 (Plant Extracts). EC 3-2-1-1 (alpha-Amylases). EC 3-2-1-20 (alpha-Glucosidases).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.biopha.2020.111151
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=0753-3322&title=Biomedicine+%26+Pharmacotherapy&atitle=Garcinia+linii+extracts+exert+the+mediation+of+anti-diabetic+molecular+targets+on+anti-hyperglycemia.&volume=134&issue=&spage=111151&epage=&date=2021&doi=10.1016%2Fj.biopha.2020.111151&pmid=33370629&sid=OVID:medline
+
+<1001>
+Unique Identifier
+ 33361317
+Title
+ Plasma and Urine Metabolite Profiles Impacted by Increased Dietary Navy Bean Intake in Colorectal Cancer Survivors: A Randomized-Controlled Trial.
+Source
+ Cancer Prevention Research. 14(4):497-508, 2021 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zarei I; Baxter BA; Oppel RC; Borresen EC; Brown RJ; Ryan EP
+Author NameID
+ Ryan, Elizabeth P; ORCID: https://orcid.org/0000-0002-1577-0919
+Authors Full Name
+ Zarei, Iman; Baxter, Bridget A; Oppel, Renee C; Borresen, Erica C; Brown, Regina J; Ryan, Elizabeth P.
+Institution
+ Zarei, Iman. Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
+ Baxter, Bridget A. Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
+ Oppel, Renee C. Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
+ Borresen, Erica C. Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
+ Brown, Regina J. University of Colorado School of Medicine, Aurora, Colorado.
+ Ryan, Elizabeth P. Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado. E.P.Ryan@colostate.edu.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ Body Fluids/ch [Chemistry]
+ Body Fluids/me [Metabolism]
+ *Cancer Survivors/sn [Statistics & Numerical Data]
+ Case-Control Studies
+ Colorectal Neoplasms/bl [Blood]
+ Colorectal Neoplasms/dh [Diet Therapy]
+ *Colorectal Neoplasms/pa [Pathology]
+ Colorectal Neoplasms/ur [Urine]
+ *Diet
+ Eating
+ *Fabaceae/ch [Chemistry]
+ Follow-Up Studies
+ *Gastrointestinal Microbiome
+ Humans
+ *Metabolome
+ Obesity/pp [Physiopathology]
+ *Phytochemicals/ad [Administration & Dosage]
+ Prognosis
+ Single-Blind Method
+Abstract
+ Navy beans contain bioactive phytochemicals with colon cancer prevention properties as demonstrated in carcinogen-induced animal models. Human studies support that dietary navy bean intake modulates metabolism by the gut microbiome. This study investigated the effect of navy bean ingestion on plasma and urine metabolite profiles of overweight and obese colorectal cancer survivors. Twenty participants completed a single-blinded, randomized-controlled dietary intervention with precooked navy beans (35 g bean powder/day) or control (0 g/day) for 4 weeks. Plasma and urine were collected at baseline, 2 weeks, and 4 weeks following consumption. Nontargeted metabolomics was applied to study meals and snacks, navy beans, plasma, and urine. Increased navy bean consumption was hypothesized to (i) delineate dietary biomarkers and (ii) promote metabolic shifts relevant for cancer protection in the plasma and urine metabolome. At 4 weeks, 16 plasma and 16 urine metabolites were significantly different in the navy bean intervention group compared with placebo control (P < 0.05). Increased plasma 2,3-dihydroxy-2-methylbutyrate (1.34-fold), S-methylcysteine (1.92-fold), and pipecolate (3.89-fold), and urine S-adenosylhomocysteine (2.09-fold) and cysteine (1.60-fold) represent metabolites with cancer-protective actions following navy bean consumption. Diet-derived metabolites were detected in plasma or urine and confirmed for presence in the navy bean intervention meals and snacks. These included 3-(4-hydroxyphenyl)propionate, betaine, pipecolate, S-methylcysteine, choline, eicosapentaenoate (20:5n3), benzoate, S-adenosylhomocysteine, N-delta-acetylornithine, cysteine, 3-(4-hydroxyphenyl)lactate, gentisate, hippurate, 4-hydroxyhippurate, and salicylate. The navy bean dietary intervention for 4 weeks showed changes to pathways of metabolic importance to colorectal cancer prevention and merit continued attention for dietary modulation in future high-risk cohort investigations. PREVENTION RELEVANCE: This clinical study suggests that increased consumption of navy beans would deliver bioactive metabolites to individuals at high risk for colorectal cancer recurrence and produce metabolic shifts in plasma and urine profiles. Copyright ©2020 American Association for Cancer Research.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phytochemicals).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1158%2f1940-6207.CAPR-20-0270
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zarei&issn=1940-6215&title=Cancer+Prevention+Research&atitle=Plasma+and+Urine+Metabolite+Profiles+Impacted+by+Increased+Dietary+Navy+Bean+Intake+in+Colorectal+Cancer+Survivors%3A+A+Randomized-Controlled+Trial.&volume=14&issue=4&spage=497&epage=508&date=2021&doi=10.1158%2F1940-6207.CAPR-20-0270&pmid=33361317&sid=OVID:medline
+
+<1002>
+Unique Identifier
+ 33349590
+Title
+ Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human.
+Source
+ EBioMedicine. 63:103176, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schellekens H; Torres-Fuentes C; van de Wouw M; Long-Smith CM; Mitchell A; Strain C; Berding K; Bastiaanssen TFS; Rea K; Golubeva AV; Arboleya S; Verpaalen M; Pusceddu MM; Murphy A; Fouhy F; Murphy K; Ross P; Roy BL; Stanton C; Dinan TG; Cryan JF
+Authors Full Name
+ Schellekens, Harriet; Torres-Fuentes, Cristina; van de Wouw, Marcel; Long-Smith, Caitriona M; Mitchell, Avery; Strain, Conall; Berding, Kirsten; Bastiaanssen, Thomaz F S; Rea, Kieran; Golubeva, Anna V; Arboleya, Silvia; Verpaalen, Mathieu; Pusceddu, Matteo M; Murphy, Amy; Fouhy, Fiona; Murphy, Kiera; Ross, Paul; Roy, Bernard L; Stanton, Catherine; Dinan, Timothy G; Cryan, John F.
+Institution
+ Schellekens, Harriet. APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. Electronic address: H.Schellekens@ucc.ie.
+ Torres-Fuentes, Cristina. APC Microbiome Ireland, University College Cork, Cork, Ireland.
+ van de Wouw, Marcel. APC Microbiome Ireland, University College Cork, Cork, Ireland.
+ Long-Smith, Caitriona M. APC Microbiome Ireland, University College Cork, Cork, Ireland.
+ Mitchell, Avery. Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
+ Strain, Conall. Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
+ Berding, Kirsten. APC Microbiome Ireland, University College Cork, Cork, Ireland.
+ Bastiaanssen, Thomaz F S. APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
+ Rea, Kieran. APC Microbiome Ireland, University College Cork, Cork, Ireland.
+ Golubeva, Anna V. APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
+ Arboleya, Silvia. APC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
+ Verpaalen, Mathieu. APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
+ Pusceddu, Matteo M. APC Microbiome Ireland, University College Cork, Cork, Ireland.
+ Murphy, Amy. APC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
+ Fouhy, Fiona. APC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
+ Murphy, Kiera. APC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
+ Ross, Paul. APC Microbiome Ireland, University College Cork, Cork, Ireland; College of Science Engineering & Food Science, University College Cork, Cork, Ireland.
+ Roy, Bernard L. Cremo SA, Villars-sur-Glane, Fribourg, Switzerland.
+ Stanton, Catherine. APC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
+ Dinan, Timothy G. APC Microbiome Ireland, University College Cork, Cork, Ireland; Dept of Psychiatry and Behavioural Neuroscience, University College Cork, Cork, Ireland.
+ Cryan, John F. APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
+MeSH Subject Headings
+ Adiposity
+ Adrenal Cortex Hormones/bl [Blood]
+ Animals
+ *Bifidobacterium longum/ph [Physiology]
+ Biomarkers
+ Body Weight
+ Diet, High-Fat/ae [Adverse Effects]
+ Dietary Supplements
+ Disease Models, Animal
+ *Disease Resistance
+ Energy Metabolism
+ Glucose/me [Metabolism]
+ *Host Microbial Interactions
+ Leptin/bl [Blood]
+ Male
+ Mice
+ Neuropeptides/ge [Genetics]
+ Neuropeptides/me [Metabolism]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Probiotics
+ Rodentia
+ Translational Research, Biomedical
+Keyword Heading
+ Bifidobacterium longum
+ Cortisol
+ Fasting blood glucose
+ Ghrelin
+ Gut microbiota
+ Obesity
+ Probiotic
+ Translational
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes.
+
+ METHODS: B. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention.
+
+ FINDINGS: B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]).
+
+ INTERPRETATION: This study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity.
+
+ FUNDING: This research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adrenal Cortex Hormones). 0 (Biomarkers). 0 (Leptin). 0 (Neuropeptides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.ebiom.2020.103176
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schellekens&issn=2352-3964&title=EBioMedicine&atitle=Bifidobacterium+longum+counters+the+effects+of+obesity%3A+Partial+successful+translation+from+rodent+to+human.&volume=63&issue=&spage=103176&epage=&date=2021&doi=10.1016%2Fj.ebiom.2020.103176&pmid=33349590&sid=OVID:medline
+
+<1003>
+Unique Identifier
+ 33334622
+Title
+ Epidemiology, Pathogenesis, Diagnosis and Emerging Treatment of Nonalcoholic Fatty Liver Disease. [Review]
+Source
+ Archives of Medical Research. 52(1):25-37, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Makri E; Goulas A; Polyzos SA
+Authors Full Name
+ Makri, Evangelia; Goulas, Antonis; Polyzos, Stergios A.
+Institution
+ Makri, Evangelia. First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
+ Goulas, Antonis. First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
+ Polyzos, Stergios A. First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: spolyzos@auth.gr.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ Carcinoma, Hepatocellular/co [Complications]
+ Carcinoma, Hepatocellular/di [Diagnosis]
+ Carcinoma, Hepatocellular/ep [Epidemiology]
+ Carcinoma, Hepatocellular/th [Therapy]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/th [Therapy]
+ Humans
+ Life Style
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/ep [Epidemiology]
+ Liver Cirrhosis/et [Etiology]
+ Liver Cirrhosis/th [Therapy]
+ Liver Neoplasms/co [Complications]
+ Liver Neoplasms/di [Diagnosis]
+ Liver Neoplasms/ep [Epidemiology]
+ Liver Neoplasms/th [Therapy]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/th [Therapy]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/th [Therapy]
+ Prevalence
+ Risk Factors
+ Therapies, Investigational/mt [Methods]
+ Therapies, Investigational/td [Trends]
+Keyword Heading
+ Fibrosis
+ Insulin resistance
+ Nonalcoholic fatty liver disease
+ Nonalcoholic steatohepatitis
+ Steatosis
+ Treatment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with an estimated rising prevalence, in concert with the epidemics of obesity and type 2 diabetes. The pathogenesis of NAFLD is not fully elucidated. Besides weight gain and insulin resistance, many other factors seem to contribute, including adipokines, gut microbiota and genetic predisposition. The disease starts as hepatic steatosis, which may proceed to nonalcoholic steatohepatitis (NASH); if fibrosis is added, the risk of cirrhosis and/or hepatocellular carcinoma is augmented. Liver biopsy is considered the gold standard for the diagnosis and staging of NAFLD; the early use of reliable and easily applied diagnostic tools, such as noninvasive biomarkers, is needed to identify patients at different-preferably early-stages of disease however. Whilst lifestyle modification is the first step to manage NAFLD, there is poor compliance, leading to the need of drug therapy. Accordingly, a variety of medications is under investigation. Given the multifaceted pathophysiology of NAFLD, probably, a combination of approaches in an individualized basis may be a more appropriate management. This review summarizes evidence on the epidemiology, pathogenesis, diagnosis and treatment of NAFLD. Copyright © 2020 IMSS. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.arcmed.2020.11.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Makri&issn=0188-4409&title=Archives+of+Medical+Research&atitle=Epidemiology%2C+Pathogenesis%2C+Diagnosis+and+Emerging+Treatment+of+Nonalcoholic+Fatty+Liver+Disease.&volume=52&issue=1&spage=25&epage=37&date=2021&doi=10.1016%2Fj.arcmed.2020.11.010&pmid=33334622&sid=OVID:medline
+
+<1004>
+Unique Identifier
+ 33323785
+Title
+ Association Between High Body Mass Index and Mortality Following Myocardial Injury After Noncardiac Surgery.
+Source
+ Anesthesia & Analgesia. 132(4):960-968, 2021 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee SH; Yang K; Park J; Lee JH; Min JJ; Kwon JH; Yeo J; Kim J; Hyeon CW; Choi JH; Lee SC; Gwon HC; Kim K; Ahn J; Lee SM
+Authors Full Name
+ Lee, Seung-Hwa; Yang, Kwangmo; Park, Jungchan; Lee, Jong Hwan; Min, Jeong Jin; Kwon, Ji-Hye; Yeo, Junghyun; Kim, Jihoon; Hyeon, Cheol Won; Choi, Jin-Ho; Lee, Sang-Chol; Gwon, Hyeon-Cheol; Kim, Kyunga; Ahn, Joonghyun; Lee, Sangmin Maria.
+Institution
+ Lee, Seung-Hwa. From the Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute.
+ Yang, Kwangmo. Centers for Health Promotion.
+ Park, Jungchan. Department of Anesthesiology and Pain Medicine.
+ Lee, Jong Hwan. Department of Anesthesiology and Pain Medicine.
+ Min, Jeong Jin. Department of Anesthesiology and Pain Medicine.
+ Kwon, Ji-Hye. Centers for Health Promotion.
+ Yeo, Junghyun. Department of Anesthesiology and Pain Medicine.
+ Kim, Jihoon. From the Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute.
+ Hyeon, Cheol Won. From the Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute.
+ Choi, Jin-Ho. From the Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute.
+ Choi, Jin-Ho. Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
+ Lee, Sang-Chol. From the Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute.
+ Gwon, Hyeon-Cheol. From the Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute.
+ Kim, Kyunga. Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea.
+ Kim, Kyunga. Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea.
+ Ahn, Joonghyun. Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
+ Lee, Sangmin Maria. Department of Anesthesiology and Pain Medicine.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Female
+ Heart Diseases/di [Diagnosis]
+ Heart Diseases/et [Etiology]
+ *Heart Diseases/mo [Mortality]
+ Humans
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/mo [Mortality]
+ Protective Factors
+ Registries
+ Risk Assessment
+ Risk Factors
+ Surgical Procedures, Operative/ae [Adverse Effects]
+ *Surgical Procedures, Operative/mo [Mortality]
+ Time Factors
+ Treatment Outcome
+ Troponin I/bl [Blood]
+Abstract
+ BACKGROUND: Despite an association between obesity and increased risks for various diseases, obesity has been paradoxically reported to correlate with improved mortality in patients with established cardiovascular disease. However, its effect has not been evaluated to date in patients with myocardial injury after noncardiac surgery (MINS).
+
+ METHODS: From January 2010 to June 2019, of a total of 35,269 adult patients with postoperative cardiac troponin level data, 5633 (16.0%) patients had MINS as diagnosed by postoperative cardiac troponin I above the 99th-percentile upper reference of 40 ng.L-1 using the TnI-Ultra immunoassay. Patients with MINS were divided into 3 groups according to body mass index (BMI), with 3246 (57.6%) were in the normal (18.5-25 kg.m-2), 425 (7.5%) in the low BMI (<18.5 kg.m-2), and 1962 (34.8%) in the high BMI (>=25 kg.m-2) groups, respectively. The primary outcome was mortality during the first year after surgery, and the mortality during 30 days was also compared.
+
+ RESULTS: Following adjustment for confounding with inverse probability of treatment weighting, mortality within the first year appeared to be significantly lower in the high BMI group compared with the normal (14.8% vs 20.9%; hazard ratio [HR], 0.75; 95% confidence interval [CI], 0.66-0.85; P < .001) and the low BMI (14.8% vs 25.6%; HR: 0.56; 95% CI, 0.48-0.66; P < .001) groups.
+
+ CONCLUSIONS: High BMI may be associated with decreased mortality following MINS. Further investigations are needed to support this finding. Copyright © 2020 International Anesthesia Research Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Troponin I).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1213%2fANE.0000000000005303
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=0003-2999&title=Anesthesia+%26+Analgesia&atitle=Association+Between+High+Body+Mass+Index+and+Mortality+Following+Myocardial+Injury+After+Noncardiac+Surgery.&volume=132&issue=4&spage=960&epage=968&date=2021&doi=10.1213%2FANE.0000000000005303&pmid=33323785&sid=OVID:medline
+
+<1005>
+Unique Identifier
+ 33310034
+Title
+ Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-alpha signaling in obese mice.
+Source
+ Life Sciences. 266:118868, 2021 Feb 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Diniz TA; de Lima Junior EA; Teixeira AA; Biondo LA; da Rocha LAF; Valadao IC; Silveira LS; Cabral-Santos C; de Souza CO; Rosa Neto JC
+Authors Full Name
+ Diniz, Tiego Aparecido; de Lima Junior, Edson Alves; Teixeira, Alexandre Abilio; Biondo, Luana Amorim; da Rocha, Lucas Ariel Fernandes; Valadao, Iuri Cordeiro; Silveira, Loreana Sanches; Cabral-Santos, Carol; de Souza, Camila Oliveira; Rosa Neto, Jose Cesar.
+Institution
+ Diniz, Tiego Aparecido. Immunometabolism Research Group, Department of Cell and Developmental Biology, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, CEP 05508-900 Butanta, Sao Paulo, Brazil.
+ de Lima Junior, Edson Alves. Immunometabolism Research Group, Department of Cell and Developmental Biology, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, CEP 05508-900 Butanta, Sao Paulo, Brazil.
+ Teixeira, Alexandre Abilio. Immunometabolism Research Group, Department of Cell and Developmental Biology, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, CEP 05508-900 Butanta, Sao Paulo, Brazil.
+ Biondo, Luana Amorim. Immunometabolism Research Group, Department of Cell and Developmental Biology, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, CEP 05508-900 Butanta, Sao Paulo, Brazil.
+ da Rocha, Lucas Ariel Fernandes. Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
+ Valadao, Iuri Cordeiro. Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
+ Silveira, Loreana Sanches. Immunometabolism Research Group, Department of Cell and Developmental Biology, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, CEP 05508-900 Butanta, Sao Paulo, Brazil.
+ Cabral-Santos, Carol. Exercise and Immunometabolism Research Group, Department of Physical Education, University of the State of Sao Paulo, Rua Roberto Simonsen, 305, 19060-900 Presidente Prudente, SP, Brazil.
+ de Souza, Camila Oliveira. Immunometabolism Research Group, Department of Cell and Developmental Biology, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, CEP 05508-900 Butanta, Sao Paulo, Brazil.
+ Rosa Neto, Jose Cesar. Immunometabolism Research Group, Department of Cell and Developmental Biology, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, CEP 05508-900 Butanta, Sao Paulo, Brazil. Electronic address: jrosaneto@usp.br.
+MeSH Subject Headings
+ AMP-Activated Protein Kinases/ge [Genetics]
+ *AMP-Activated Protein Kinases/me [Metabolism]
+ Animals
+ Biomarkers/an [Analysis]
+ Cytokines/me [Metabolism]
+ Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ *Inflammation/pc [Prevention & Control]
+ *Insulin Resistance
+ Liver/im [Immunology]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease/th [Therapy]
+ *Obesity/co [Complications]
+ PPAR alpha/ge [Genetics]
+ *PPAR alpha/me [Metabolism]
+ *Physical Conditioning, Animal
+ Signal Transduction
+Keyword Heading
+ AMPK and inflammation
+ Exercise
+ Hepatic steatosis
+ NAFLD
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Liver steatosis is one of the main drivers for the development of whole-body insulin resistance. Conversely, aerobic training (AT) has been suggested as non-pharmacological tool to improve liver steatosis, however, the underlying molecular mechanism remains unclear. Therefore, the aim of this study was to analyze the effect of 8-weeks AT in non-alcoholic liver disease (NAFLD) outcomes in obese mice. Male C57BL/6 J wild type (WT) were fed with standard (SD) or high-fat diet (HFD) for 12-weeks. Another group fed with HFD underwent 8-weeks of AT (60% of maximum velocity), initiated at the 5th week of experimental protocol. We measured metabolic, body composition parameters, protein and gene expression inflammatory and metabolic mediators. We found that AT attenuates the weight gain, but not body fat accumulation. AT improved triacylglycerol and non-esterified fatty acid plasma concentrations, and also whole-body insulin resistance. Regarding NAFLD, AT decreased the progression of macrovesicular steatosis and inflammation through the upregulation of AMPK Thr172 phosphorylation and PPAR-alpha protein expression. Moreover, although no effects of intervention in PPAR-gamma protein concentration were observed, we found increased levels of its target genes Cd36 and Scd1 in exercised group, demonstrating augmented transcriptional activity. AT reduced liver cytokines concentrations, such as TNF-alpha, IL-10, MCP-1 and IL-6, regardless of increased Ser536 NF-kappaB phosphorylation. In fact, none of the interventions regulated NF-kappaB target genes Il1b and Cccl2, demonstrating its low transcriptional activity. Therefore, we conclude that AT attenuates the progression of liver macrovesicular steatosis and inflammation through AMPK-PPAR-alpha signaling and PPAR-gamma activation, respectively, improving insulin resistance in obese mice. Copyright © 2020. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (PPAR alpha). EC 2-7-11-31 (AMP-Activated Protein Kinases).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.lfs.2020.118868
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Diniz&issn=0024-3205&title=Life+Sciences&atitle=Aerobic+training+improves+NAFLD+markers+and+insulin+resistance+through+AMPK-PPAR-alpha+signaling+in+obese+mice.&volume=266&issue=&spage=118868&epage=&date=2021&doi=10.1016%2Fj.lfs.2020.118868&pmid=33310034&sid=OVID:medline
+
+<1006>
+Unique Identifier
+ 33309719
+Title
+ Ileal interposition improves metabolic syndrome parameters in a rat model of metabolic syndrome induced by monosodium glutamate.
+Source
+ Life Sciences. 266:118846, 2021 Feb 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tunc-Ata M; Altintas F; Senol H; Nizamoglu E; Kucukatay V
+Authors Full Name
+ Tunc-Ata, Melek; Altintas, Fatih; Senol, Hande; Nizamoglu, Erol; Kucukatay, Vural.
+Institution
+ Tunc-Ata, Melek. Pamukkale University Medical Faculty Department of Physiology, Denizli 20160, Turkey. Electronic address: melekt@pau.edu.tr.
+ Altintas, Fatih. Pamukkale University Medical Faculty Department of Physiology, Denizli 20160, Turkey. Electronic address: faltintas@pau.edu.tr.
+ Senol, Hande. Pamukkale University Medical Faculty Department of Biostatistics, Denizli 20160, Turkey. Electronic address: hsenol@pau.edu.tr.
+ Nizamoglu, Erol. Akdeniz University Medical Faculty Department of Physiology, Antalya 20160, Turkey. Electronic address: enizam@akdeniz.edu.tr.
+ Kucukatay, Vural. Pamukkale University Medical Faculty Department of Physiology, Denizli 20160, Turkey. Electronic address: vkucukatay@pau.edu.tr.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/an [Analysis]
+ *Flavoring Agents/to [Toxicity]
+ *Ileum/su [Surgery]
+ Male
+ Metabolic Syndrome/ci [Chemically Induced]
+ Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pa [Pathology]
+ *Metabolic Syndrome/th [Therapy]
+ *Obesity/su [Surgery]
+ Rats
+ Rats, Wistar
+ *Sodium Glutamate/to [Toxicity]
+Keyword Heading
+ Glucagon like peptide-1
+ Glucagon like peptide-1 receptor
+ Ileal interposition
+ Metabolic syndrome
+ Monosodium glutamate
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities. Anatomically restructuring of the gastrointestinal system has recently been an important subject of research in the treatment of MetS and closely related diseases. The aim of this study is to ensure the remission of parameters that define MetS by ileal interposition (IT) and to examine the effect of IT on plasma total GLP-1 and pancreatic GLP-1R expression.
+
+ MAIN METHODS: To induce MetS, newborn male Wistar albino rats were given MSG (4 g/mg) on days 0, 2, 4, 6, 8, and 10. The control group was injected with saline. In the 5th month, IT or sham surgery was performed on the MetS rats. The lipid levels, abdominal obesity, insulin level, OGTT, Lee index, HOMA-IR, plasma GLP-1 and pancreas GLP-1R expression were evaluated 2 months after surgery.
+
+ KEY FINDINGS: The results showed that IT significantly improved hyperinsulinemia (p = 0.013) and lipid profile (TG p = 0.0001; TCHOL p = 0.018; HDL p = 0.001). Furthermore, it normalized the Lee index (p = 0.006) and insulin resistance. The IT did not affect the secretion of the GLP-1, but the expression levels of pancreas GLP-1R were increased (p = 0.006).
+
+ SIGNIFICANCE: IT surgery corrected the MetS parameters in this rat model. The healing effects of IT surgery could be caused by mechanisms in the target tissues of insulin. The decrease in pancreatic GLP-1R levels in the MetS groups might be a compensatory response to the harmful effects of hyperinsulinemia in these groups. These results show that IT can be useful in the treatment of MetS. Copyright © 2020. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Flavoring Agents). W81N5U6R6U (Sodium Glutamate).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.lfs.2020.118846
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tunc-Ata&issn=0024-3205&title=Life+Sciences&atitle=Ileal+interposition+improves+metabolic+syndrome+parameters+in+a+rat+model+of+metabolic+syndrome+induced+by+monosodium+glutamate.&volume=266&issue=&spage=118846&epage=&date=2021&doi=10.1016%2Fj.lfs.2020.118846&pmid=33309719&sid=OVID:medline
+
+<1007>
+Unique Identifier
+ 33284184
+Title
+ Role of Noninvasive Tests in Clinical Gastroenterology Practices to Identify Patients With Nonalcoholic Steatohepatitis at High Risk of Adverse Outcomes: Expert Panel Recommendations. [Review]
+Source
+ American Journal of Gastroenterology. 116(2):254-262, 2021 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Younossi ZM; Noureddin M; Bernstein D; Kwo P; Russo M; Shiffman ML; Younes Z; Abdelmalek M
+Authors Full Name
+ Younossi, Zobair M; Noureddin, Mazen; Bernstein, David; Kwo, Paul; Russo, Mark; Shiffman, Mitchell L; Younes, Ziad; Abdelmalek, Manal.
+Institution
+ Younossi, Zobair M. Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia, USA.
+ Noureddin, Mazen. Liver Disease and Transplant Center, Cedars-Sinai, Los Angeles, California, USA.
+ Bernstein, David. Division of Hepatology, Northwell Health, Manhasset, New York, USA.
+ Kwo, Paul. Department of Medicine-Med/Gastroenterology and Hepatology, Stanford University, Palo Alto, California, USA.
+ Russo, Mark. Transplant and Liver Center, Atrium Health, Charlotte, North Carolina, USA.
+ Shiffman, Mitchell L. Department of Hepatology, Liver Institute of Virginia, Bon Secour Mercy Health, Richmond, Virginia, USA.
+ Younes, Ziad. GastroOne, Germantown, Tennessee, USA.
+ Abdelmalek, Manal. Department of Medicine, Duke University, Durham, North Carolina, USA.
+MeSH Subject Headings
+ Age Factors
+ Alanine Transaminase/bl [Blood]
+ Algorithms
+ Aspartate Aminotransferases/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Biopsy
+ Body Mass Index
+ Comorbidity
+ Decision Trees
+ Diabetes Mellitus/ep [Epidemiology]
+ Elasticity Imaging Techniques
+ Gastroenterology
+ Glucose Intolerance/ep [Epidemiology]
+ Humans
+ Hyaluronic Acid/bl [Blood]
+ Liver/pa [Pathology]
+ Liver Cirrhosis/bl [Blood]
+ *Liver Cirrhosis/dg [Diagnostic Imaging]
+ Liver Cirrhosis/ep [Epidemiology]
+ Liver Cirrhosis/pa [Pathology]
+ Magnetic Resonance Imaging
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/ep [Epidemiology]
+ Peptide Fragments/bl [Blood]
+ Platelet Count
+ Practice Guidelines as Topic
+ Procollagen/bl [Blood]
+ Risk Assessment
+ Serum Albumin/me [Metabolism]
+ Tissue Inhibitor of Metalloproteinase-1/bl [Blood]
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) is generally considered a silent and potentially reversible condition. The subtype of NAFLD that can be classified as nonalcoholic steatohepatitis (NASH) can progress to advanced fibrosis and cirrhosis. Because of the metabolic nature of the pathogenic mechanism underlying NAFLD and NASH, it is often accompanied by common comorbidities such as obesity, insulin resistance, and type 2 diabetes mellitus. The increase in the prevalence of these comorbidities has resulted in a parallel increase in the prevalence of NAFLD and NASH, globally, nationally, and even in children. In recent years, it has been identified that the stage of fibrosis is the most important predictor of liver outcomes; therefore, identifying patients with NAFLD and NASH with more advanced stages of fibrosis can be essential for optimal management. Several noninvasive tools for diagnosing and staging NAFLD and NASH are available, but simple and straightforward recommendations on the use of these tools are not. Recognizing these unmet needs, hepatologists who are members of the American College of Gastroenterology and the Chronic Liver Disease Foundation created a practical decision tree/algorithm to risk stratify NAFLD/NASH as a resource in gastroenterology/hepatology clinical practices. This review will provide insight into how this algorithm was developed, describe it in detail, and provide recommendations for its use in clinical practice. Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (Procollagen). 0 (Serum Albumin). 0 (TIMP1 protein, human). 0 (Tissue Inhibitor of Metalloproteinase-1). 0 (procollagen Type III-N-terminal peptide). 9004-61-9 (Hyaluronic Acid). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.14309%2fajg.0000000000001054
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Younossi&issn=0002-9270&title=American+Journal+of+Gastroenterology&atitle=Role+of+Noninvasive+Tests+in+Clinical+Gastroenterology+Practices+to+Identify+Patients+With+Nonalcoholic+Steatohepatitis+at+High+Risk+of+Adverse+Outcomes%3A+Expert+Panel+Recommendations.&volume=116&issue=2&spage=254&epage=262&date=2021&doi=10.14309%2Fajg.0000000000001054&pmid=33284184&sid=OVID:medline
+
+<1008>
+Unique Identifier
+ 33280078
+Title
+ Cardiometabolic Syndrome: An Update on Available Mouse Models. [Review]
+Source
+ Thrombosis & Haemostasis. 121(6):703-715, 2021 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aravani D; Kassi E; Chatzigeorgiou A; Vakrou S
+Authors Full Name
+ Aravani, Dimitra; Kassi, Eva; Chatzigeorgiou, Antonios; Vakrou, Styliani.
+Institution
+ Aravani, Dimitra. Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
+ Kassi, Eva. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
+ Chatzigeorgiou, Antonios. Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
+ Chatzigeorgiou, Antonios. Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.
+ Vakrou, Styliani. Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
+ Vakrou, Styliani. Department of Cardiology, "Laiko" General Hospital, Athens, Greece.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ Hyperlipidemias/bl [Blood]
+ Hyperlipidemias/ge [Genetics]
+ Hyperlipidemias/pp [Physiopathology]
+ Hyperlipidemias/th [Therapy]
+ *Hyperlipidemias
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Lipids/bl [Blood]
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ge [Genetics]
+ Metabolic Syndrome/pp [Physiopathology]
+ Metabolic Syndrome/th [Therapy]
+ *Metabolic Syndrome
+ Mice
+ Mice, Transgenic
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ *Obesity
+Abstract
+ Cardiometabolic syndrome (CMS), a disease entity characterized by abdominal obesity, insulin resistance (IR), hypertension, and hyperlipidemia, is a global epidemic with approximately 25% prevalence in adults globally. CMS is associated with increased risk for cardiovascular disease (CVD) and development of diabetes. Due to its multifactorial etiology, the development of several animal models to simulate CMS has contributed significantly to the elucidation of the disease pathophysiology and the design of therapies. In this review we aimed to present the most common mouse models used in the research of CMS. We found that CMS can be induced either by genetic manipulation, leading to dyslipidemia, lipodystrophy, obesity and IR, or obesity and hypertension, or by administration of specific diets and drugs. In the last decade, the ob/ob and db/db mice were the most common obesity and IR models, whereas Ldlr-/- and Apoe-/- were widely used to induce hyperlipidemia. These mice have been used either as a single transgenic or combined with a different background with or without diet treatment. High-fat diet with modifications is the preferred protocol, generally leading to increased body weight, hyperlipidemia, and IR. A plethora of genetically engineered mouse models, diets, drugs, or synthetic compounds that are available have advanced the understanding of CMS. However, each researcher should carefully select the most appropriate model and validate its consistency. It is important to consider the differences between strains of the same animal species, different animals, and most importantly differences to human when translating results. Copyright Thieme. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Lipids).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1055%2fs-0040-1721388
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aravani&issn=0340-6245&title=Thrombosis+%26+Haemostasis&atitle=Cardiometabolic+Syndrome%3A+An+Update+on+Available+Mouse+Models.&volume=121&issue=6&spage=703&epage=715&date=2021&doi=10.1055%2Fs-0040-1721388&pmid=33280078&sid=OVID:medline
+
+<1009>
+Unique Identifier
+ 33278406
+Title
+ Examining the obesity paradox: A moderating effect of fitness on adipose endocrine function in older adults.
+Source
+ Mechanisms of Ageing & Development. 193:111406, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nicholson E; Allison DJ; Bullock A; Heisz JJ
+Authors Full Name
+ Nicholson, E; Allison, D J; Bullock, A; Heisz, J J.
+Institution
+ Nicholson, E. McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4L8, Canada.
+ Allison, D J. McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4L8, Canada.
+ Bullock, A. University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 2B5, Canada.
+ Heisz, J J. McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4L8, Canada. Electronic address: heiszjj@mcmaster.ca.
+MeSH Subject Headings
+ Adipose Tissue/im [Immunology]
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue
+ Adiposity/ph [Physiology]
+ Aged
+ *Aging/ph [Physiology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Canada/ep [Epidemiology]
+ Cardiometabolic Risk Factors
+ *Cardiorespiratory Fitness/ph [Physiology]
+ Cross-Sectional Studies
+ Effect Modifier, Epidemiologic
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Leptin/bl [Blood]
+ Leptin/me [Metabolism]
+ *Leptin
+ Male
+ Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Obesity/mo [Mortality]
+ Obesity/pp [Physiopathology]
+ *Obesity
+ *Physical Fitness/ph [Physiology]
+ Protective Factors
+Keyword Heading
+ Ageing
+ Leptin
+ Obesity paradox
+ Physical fitness
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Despite evidence linking obesity with increased mortality, older adults with excessive adiposity seem protected, resulting in a so-called obesity paradox. Obesity is characterized by leptin resistance, which contributes to increased risk of all-cause mortality. Therefore, lifestyle factors, such as physical fitness, that lower leptin independent of adiposity may be confounding the obesity paradox. To investigate this, we evaluated whether physical fitness moderated the relationship between leptin and adiposity. We found older adults with higher fitness had lower body mass (r(39) = -0.43, p < 0.01), leptin (r(39) = -0.29, p = 0.03) and inflammation (IL-1beta: (r(39) = -0.69, p < 0.01); TNF-alpha: (r(39) = -0.30, p = 0.03)). Fitness moderated the relationship between leptin and adiposity (F(5, 37) = 3.73, p < 0.01, R2 = 0.33) to reveal the obesity paradox in moderately and high fit individuals (b = 216.24, t(37) = 1.46, p = 0.15; b= -88.10, t(37) = -0.49, p = 0.63) but not in low fit individuals. These results show the link between obesity and mortality may not be dependent on total adiposity, but rather on endocrine function and adipocyte leptin secretion. These results have important implications for older adults struggling to maintain healthy body composition and suggest that fitness may promote overall wellbeing. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.mad.2020.111406
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nicholson&issn=0047-6374&title=Mechanisms+of+Ageing+%26+Development&atitle=Examining+the+obesity+paradox%3A+A+moderating+effect+of+fitness+on+adipose+endocrine+function+in+older+adults.&volume=193&issue=&spage=111406&epage=&date=2021&doi=10.1016%2Fj.mad.2020.111406&pmid=33278406&sid=OVID:medline
+
+<1010>
+Unique Identifier
+ 33276220
+Title
+ Lack of change in serum sCD36 concentration in children with non-alcoholic fatty liver disease - A preliminary study.
+Source
+ Advances in Medical Sciences. 66(1):35-40, 2021 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bobrus-Chociej A; Wasilewska N; Harasim-Symbor E; Flisiak-Jackiewicz M; Wojtkowska M; Chabowski A; Lebensztejn D
+Authors Full Name
+ Bobrus-Chociej, Anna; Wasilewska, Natalia; Harasim-Symbor, Ewa; Flisiak-Jackiewicz, Marta; Wojtkowska, Malgorzata; Chabowski, Adrian; Lebensztejn, Dariusz.
+Institution
+ Bobrus-Chociej, Anna. Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Bialystok, Poland. Electronic address: anna.bobrus-chociej@umb.edu.pl.
+ Wasilewska, Natalia. Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Bialystok, Poland.
+ Harasim-Symbor, Ewa. Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
+ Flisiak-Jackiewicz, Marta. Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Bialystok, Poland.
+ Wojtkowska, Malgorzata. Department of Radiology, University Children's Clinical Hospital of Bialystok, Bialystok, Poland.
+ Chabowski, Adrian. Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
+ Lebensztejn, Dariusz. Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Bialystok, Poland.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ *CD36 Antigens/bl [Blood]
+ Case-Control Studies
+ Child
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+Keyword Heading
+ Children
+ Metabolic syndrome
+ Non-alcoholic fatty liver disease
+ Obesity
+ sCD36
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Non-alcoholic fatty liver disease (NAFLD) is increasingly being recognized in the pediatric population, therefore, the search for non-invasive parameters to predict progression of NAFLD is of great interest. The aim of this study was to assess serum concentration of sCD36 in children with obesity and to determine its diagnostic value in pediatric NAFLD.
+
+ PATIENTS AND METHODS: The study group consisted of 50 children with obesity aged 8-17.5 years, admitted to our Department because of suspected liver pathology. Selected liver diseases were excluded in the examined group. Anthropometry, laboratory tests (including the concentration of sCD36) and liver ultrasound, were performed in all subjects.
+
+ RESULTS: NAFLD was confirmed in 16 out of 50 patients with obesity. There was significantly higher activity of ALT, AST, GGT, and increased waist-hip ratio WHR in individuals with NAFLD in comparison to non-hepatopathic children with obesity. We did not find a significant difference between sCD36 concentration in patients with obesity and NAFLD and non-hepathopathic patients with obesity. We also did not find a significant difference between sCD36 concentration in children with obesity in comparison to the control group and between mild (grade 1) vs. advanced (grade >=2) steatosis. Correlation of sCD36 concentration with anthropometric, biochemical, and bioimpedance parameters in children with obesity was confirmed only with body fat percentage.
+
+ CONCLUSIONS: sCD36 is not a suitable parameter to differentiate children with NAFLD from non-hepatopathic children with obesity and controls without obesity. Further studies on a larger pediatric population are needed to confirm these findings. Copyright © 2020 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CD36 Antigens). 0 (CD36 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.advms.2020.11.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bobrus-Chociej&issn=1896-1126&title=Advances+in+Medical+Sciences&atitle=Lack+of+change+in+serum+sCD36+concentration+in+children+with+non-alcoholic+fatty+liver+disease+-+A+preliminary+study.&volume=66&issue=1&spage=35&epage=40&date=2021&doi=10.1016%2Fj.advms.2020.11.004&pmid=33276220&sid=OVID:medline
+
+<1011>
+Unique Identifier
+ 33270290
+Title
+ The hematologic consequences of obesity. [Review]
+Source
+ European Journal of Haematology. 106(3):306-319, 2021 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Purdy JC; Shatzel JJ
+Author NameID
+ Purdy, Johanna C; ORCID: https://orcid.org/0000-0002-7978-2345
+Authors Full Name
+ Purdy, Johanna C; Shatzel, Joseph J.
+Institution
+ Purdy, Johanna C. Division of General Internal Medicine and Geriatrics, Oregon Health & Science University, Portland, OR, USA.
+ Shatzel, Joseph J. Division of Hematology and Oncology, Oregon Health & Science University, Portland, OR, USA.
+ Shatzel, Joseph J. Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Cytokines/bl [Blood]
+ Cytokines/me [Metabolism]
+ Disease Susceptibility
+ Humans
+ Inflammation/me [Metabolism]
+ Inflammation Mediators/bl [Blood]
+ Inflammation Mediators/me [Metabolism]
+ Leukocyte Count
+ Leukocytosis
+ *Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Sex Factors
+Keyword Heading
+ anemia
+ iron deficiency
+ leukocytosis
+ thrombocytosis
+ venous thromboembolism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic risk. We performed a literature search which largely surfaced observational studies, with a few systematic reviews and meta-analyses of these studies. We took care to review the mechanisms driving an inflammatory state and obesity's effect on white blood cells, red blood cells, platelets, and thrombotic risk. There is an observed relative, and sometimes absolute leukocytosis driven by this inflammatory state. Obesity is also associated with increased platelet counts and an increased risk for venous thromboembolism (VTE). Lastly, the association between obesity, iron deficiency (ID), and red blood cell counts may be present but remains uncertain. Recognizing the above associations may provide clinicians with reassurance regarding otherwise unexplained hematologic abnormalities in obese individuals. We hope this review will prompt future studies to further understand the underlying mechanisms driving these abnormalities and identify modifiable risk factors and potential therapeutic targets to prevent the development of probable obesity-associated conditions with significant morbidity and mortality, such as ID and VTE. Copyright © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fejh.13560
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Purdy&issn=0902-4441&title=European+Journal+of+Haematology&atitle=The+hematologic+consequences+of+obesity.&volume=106&issue=3&spage=306&epage=319&date=2021&doi=10.1111%2Fejh.13560&pmid=33270290&sid=OVID:medline
+
+<1012>
+Unique Identifier
+ 33268179
+Title
+ Polysaccharide fraction from greens of Raphanus sativus alleviates high fat diet-induced obesity.
+Source
+ Food Chemistry. 343:128395, 2021 May 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Do MH; Lee HB; Oh MJ; Jhun H; Choi SY; Park HY
+Authors Full Name
+ Do, Moon Ho; Lee, Hye-Bin; Oh, Mi-Jin; Jhun, Hyunjhung; Choi, Sang Yoon; Park, Ho-Young.
+Institution
+ Do, Moon Ho. Research Group of Functional Food Materials, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea. Electronic address: Do.moon-ho@kfri.re.kr.
+ Lee, Hye-Bin. Research Group of Functional Food Materials, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea; Department of Food Science and Technology, Jeonbuk National University, Jeollabuk-do, 54896, Republic of Korea. Electronic address: 50023@kfri.re.kr.
+ Oh, Mi-Jin. Technical Assistance Center, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea. Electronic address: mjoh@kfri.re.kr.
+ Jhun, Hyunjhung. Technical Assistance Center, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea. Electronic address: vetian@kfri.re.kr.
+ Choi, Sang Yoon. Research Group of Functional Food Materials, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea. Electronic address: sychoi@kfri.re.kr.
+ Park, Ho-Young. Research Group of Functional Food Materials, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea. Electronic address: hypark@kfri.re.kr.
+MeSH Subject Headings
+ Adipose Tissue, White/de [Drug Effects]
+ Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ Colon/de [Drug Effects]
+ Colon/ph [Physiology]
+ Diet, High-Fat
+ Gastrointestinal Microbiome/de [Drug Effects]
+ Lipid Metabolism/de [Drug Effects]
+ Lipid Metabolism/ge [Genetics]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/pa [Pathology]
+ *Obesity/pc [Prevention & Control]
+ Plant Leaves/me [Metabolism]
+ Plant Stems/me [Metabolism]
+ *Polysaccharides/ad [Administration & Dosage]
+ Polysaccharides/me [Metabolism]
+ Polysaccharides/pd [Pharmacology]
+ Principal Component Analysis
+ *Raphanus/me [Metabolism]
+ Tight Junction Proteins/me [Metabolism]
+Keyword Heading
+ Gut microbiota
+ High fat diet
+ Obesity
+ Polysaccharide
+ Raphanus sativus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Radish (Raphanus sativus) greens are commonly used as a vegetable in Korea; however, their anti-obesity effect has not been reported yet. We prepared the polysaccharide fraction of radish greens (PRG) and assessed its anti-obesity activity in high fat diet (HFD)-induced obese C57BL/6J mice. Supplementation with 4 mg/kg PRG reduced weight gain and body fat percentage, and regulated serum biomarkers against HFD-induced obesity. Moreover, PRG treatment improved gut permeability by increasing tight junction protein expression and colon length shortening. HFD intake increased the proportion of Firmicutes and decreased the proportion of Bacteroidetes and Verrucomicrobia; however, PRG supplementation maintained gut microbial composition to normal diet condition. Moreover, PRG reduced HFD-induced increase of lipid metabolism-related protein expression, along with adipocyte size in white adipose tissue. These results indicated that PRG as a potential prebiotic, has anti-obesity properties by improving gut barrier function, modulating gut microbiota and regulating lipid metabolism. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Polysaccharides). 0 (Tight Junction Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.foodchem.2020.128395
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Do&issn=0308-8146&title=Food+Chemistry&atitle=Polysaccharide+fraction+from+greens+of+Raphanus+sativus+alleviates+high+fat+diet-induced+obesity.&volume=343&issue=&spage=128395&epage=&date=2021&doi=10.1016%2Fj.foodchem.2020.128395&pmid=33268179&sid=OVID:medline
+
+<1013>
+Unique Identifier
+ 33263724
+Title
+ Associations of Adiposity, Circulating Protein Biomarkers, and Risk of Major Vascular Diseases.
+Source
+ JAMA Cardiology. 6(3):276-286, 2021 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pang Y; Kartsonaki C; Lv J; Fairhurst-Hunter Z; Millwood IY; Yu C; Guo Y; Chen Y; Bian Z; Yang L; Chen J; Clarke R; Walters RG; Holmes MV; Li L; Chen Z
+Authors Full Name
+ Pang, Yuanjie; Kartsonaki, Christiana; Lv, Jun; Fairhurst-Hunter, Zammy; Millwood, Iona Y; Yu, Canqing; Guo, Yu; Chen, Yiping; Bian, Zheng; Yang, Ling; Chen, Junshi; Clarke, Robert; Walters, Robin G; Holmes, Michael V; Li, Liming; Chen, Zhengming.
+Institution
+ Pang, Yuanjie. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
+ Kartsonaki, Christiana. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Kartsonaki, Christiana. Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Lv, Jun. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
+ Fairhurst-Hunter, Zammy. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Millwood, Iona Y. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Millwood, Iona Y. Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Yu, Canqing. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
+ Guo, Yu. Chinese Academy of Medical Sciences, Beijing, China.
+ Chen, Yiping. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Chen, Yiping. Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Bian, Zheng. Chinese Academy of Medical Sciences, Beijing, China.
+ Yang, Ling. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Yang, Ling. Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Chen, Junshi. National Center for Food Safety Risk Assessment, Beijing, China.
+ Clarke, Robert. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Walters, Robin G. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Walters, Robin G. Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Holmes, Michael V. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Holmes, Michael V. Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Holmes, Michael V. National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, United Kingdom.
+ Li, Liming. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
+ Chen, Zhengming. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+ Chen, Zhengming. Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, United Kingdom.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Chemokine CCL2/bl [Blood]
+ Chemokine CCL7/bl [Blood]
+ China/ep [Epidemiology]
+ Cohort Studies
+ Female
+ Hepatocyte Growth Factor/bl [Blood]
+ Humans
+ Interleukin-18/bl [Blood]
+ Interleukin-6/bl [Blood]
+ Male
+ Mendelian Randomization Analysis
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ TNF-Related Apoptosis-Inducing Ligand/bl [Blood]
+Abstract
+ Importance: Obesity is associated with a higher risk of cardiovascular disease (CVD), but little is known about the role that circulating protein biomarkers play in this association.
+
+ Objective: To examine the observational and genetic associations of adiposity with circulating protein biomarkers and the observational associations of proteins with incident CVD.
+
+ Design, Setting, and Participants: This subcohort study included 628 participants from the prospective China Kadoorie Biobank who did not have a history of cancer at baseline. The Olink platform measured 92 protein markers in baseline plasma samples. Data were collected from June 2004 to January 2016 and analyzed from January 2019 to June 2020.
+
+ Exposures: Measured body mass index (BMI) obtained during the baseline survey and genetically instrumented BMI derived using 571 externally weighted single-nucleotide variants.
+
+ Main Outcomes and Measures: Cross-sectional associations of adiposity with biomarkers were examined using linear regression. Associations of biomarkers with CVD risk were assessed using Cox regression among those without prior cancer or CVD at baseline. Mendelian randomization was conducted to derive genetically estimated associations of BMI with biomarkers.
+
+ Findings: In observational analyses of 628 individuals (mean [SD] age, 52.2 [10.5] years; 385 women [61.3%]), BMI (mean [SD], 23.9 [3.6]) was positively associated with 27 proteins (per 1-SD higher BMI; eg, interleukin-6: 0.21 [95% CI, 0.12-0.29] SD; interleukin-18: 0.13 [95% CI, 0.05-0.21] SD; monocyte chemoattractant protein-1: 0.12 [95% CI, 0.04-0.20] SD; hepatocyte growth factor: 0.31 [95% CI, 0.24-0.39] SD), and inversely with 3 proteins (Fas ligand: -0.11 [95% CI, -0.19 to -0.03] SD; TNF-related weak inducer of apoptosis, -0.14 [95% CI, -0.23 to -0.06] SD; and carbonic anhydrase 9: (-0.14 [95% CI, -0.22 to -0.05] SD), with similar associations identified for other adiposity traits (eg, waist circumference [r = 0.96]). In mendelian randomization, the associations of genetically elevated BMI with specific proteins were directionally consistent with the observational associations. In meta-analyses of genetically elevated BMI with 8 proteins, combining present estimates with previous studies, the most robust associations were shown for interleukin-6 (per 1-SD higher BMI; 0.21 [95% CI, 0.13-0.29] SD), interleukin-18 (0.16 [95% CI, 0.06-0.26] SD), monocyte chemoattractant protein-1 (0.21 [95% CI, 0.11-0.30] SD), monocyte chemotactic protein-3 (0.12 [95% CI, 0.03-0.21] SD), TNF-related apoptosis-inducing ligand (0.23 [95% CI, 0.13-0.32] SD), and hepatocyte growth factor (0.14 [95% CI, 0.06-0.22] SD). Of the 30 BMI-associated biomarkers, 10 (including interleukin-6, interleukin-18, and hepatocyte growth factor) were nominally associated with incident CVD.
+
+ Conclusions and Relevance: Mendelian randomization shows adiposity to be associated with a range of protein biomarkers, with some biomarkers also showing association with CVD risk. Future studies are warranted to validate these findings and assess whether proteins may be mediators between adiposity and CVD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Chemokine CCL2). 0 (Chemokine CCL7). 0 (IL18 protein, human). 0 (IL6 protein, human). 0 (Interleukin-18). 0 (Interleukin-6). 0 (TNF-Related Apoptosis-Inducing Ligand). 67256-21-7 (Hepatocyte Growth Factor).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1001%2fjamacardio.2020.6041
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pang&issn=2380-6591&title=JAMA+Cardiology&atitle=Associations+of+Adiposity%2C+Circulating+Protein+Biomarkers%2C+and+Risk+of+Major+Vascular+Diseases.&volume=6&issue=3&spage=276&epage=286&date=2021&doi=10.1001%2Fjamacardio.2020.6041&pmid=33263724&sid=OVID:medline
+
+<1014>
+Unique Identifier
+ 33259744
+Title
+ Triglyceride Glucose Index and Related Parameters (Triglyceride Glucose-Body Mass Index and Triglyceride Glucose-Waist Circumference) Identify Nonalcoholic Fatty Liver and Liver Fibrosis in Individuals with Overweight/Obesity.
+Source
+ Metabolic Syndrome & Related Disorders. 19(3):167-173, 2021 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khamseh ME; Malek M; Abbasi R; Taheri H; Lahouti M; Alaei-Shahmiri F
+Authors Full Name
+ Khamseh, Mohammad E; Malek, Mojtaba; Abbasi, Rowshanak; Taheri, Hoda; Lahouti, Maryam; Alaei-Shahmiri, Fariba.
+Institution
+ Khamseh, Mohammad E. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
+ Malek, Mojtaba. Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
+ Abbasi, Rowshanak. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
+ Taheri, Hoda. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
+ Lahouti, Maryam. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
+ Alaei-Shahmiri, Fariba. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Cross-Sectional Studies
+ *Glucose/me [Metabolism]
+ Humans
+ Liver Cirrhosis/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Overweight/co [Complications]
+ Triglycerides
+ *Waist Circumference
+Keyword Heading
+ NAFLD
+ TyG
+ TyG-BMI
+ TyG-WC
+ liver fibrosis
+ nonalcoholic fatty liver disease
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: The triglyceride glucose (TyG) index has been proposed as a reliable surrogate marker for nonalcoholic fatty liver disease (NAFLD). Furthermore, NAFLD is strongly related with obesity. This study aimed to compare TyG index and its related parameters (TyG-waist circumference [WC] and TyG-body mass index [BMI]), comprising TyG and obesity markers, in predicting NAFLD and liver fibrosis in overweight/obese individuals without diabetes. Methods: This was a cross-sectional study consisting of 184 overweight/obese people (96 with and 88 without NAFLD), 30-65 years of age. TyG, TyG-BMI, and TyG-WC were computed using the established formula. Liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) were determined by transient elastography (FibroScan). Results: In correlation analyses, CAP and LSM were significantly associated with WC, BMI, TyG, TyG-BMI, and TyG-WC. Regression analyses highlighted TyG-WC as a significant predictor of NAFLD, with the highest standardized odds ratio (2.25, P < 0.001); while liver fibrosis was associated more strongly with TyG-BMI. In receiver operating characteristic (ROC) analysis, TyG-WC showed the largest area under the ROC curve (AUC) for detection of NAFLD (0.693, 95% confidence interval [CI]: 0.617-0.769). However, TyG-BMI was a better discriminator of liver fibrosis (AUC: 0.635, 95% CI: 0.554-0.714). TyG-WC value of 876 (sensitivity: 81.3%, specificity: 52.3%) and TyG-BMI value of 259 (sensitivity: 78.3%, specificity: 51.3%) were the optimal cutoff points to predict NAFLD and liver fibrosis, respectively. Conclusions: The results highlight the significant associations of TyG and its related indices with NAFLD, with TyG-WC being a better indicator. TyG-BMI and TyG-WC could reliably predict liver fibrosis in this population. These indices appear to be simple, practical, and affordable tools for screening NAFLD and liver fibrosis in clinical settings.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1089%2fmet.2020.0109
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khamseh&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Triglyceride+Glucose+Index+and+Related+Parameters+%28Triglyceride+Glucose-Body+Mass+Index+and+Triglyceride+Glucose-Waist+Circumference%29+Identify+Nonalcoholic+Fatty+Liver+and+Liver+Fibrosis+in+Individuals+with+Overweight%2FObesity.&volume=19&issue=3&spage=167&epage=173&date=2021&doi=10.1089%2Fmet.2020.0109&pmid=33259744&sid=OVID:medline
+
+<1015>
+Unique Identifier
+ 33249079
+Title
+ FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity. [Review]
+Source
+ European Journal of Pharmacology. 891:173758, 2021 Jan 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Benchoula K; Arya A; Parhar IS; Hwa WE
+Authors Full Name
+ Benchoula, Khaled; Arya, Aditya; Parhar, Ishwar S; Hwa, Wong Eng.
+Institution
+ Benchoula, Khaled. School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
+ Arya, Aditya. Department of Pharmacology and Therapeutics, School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia; Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), Bukit Gambir, Gelugor, Pulau Pinang, Malaysia.
+ Parhar, Ishwar S. Monash University (Malaysia) BRIMS, Jeffrey Cheah School of Medicine & Health Sciences, Malaysia.
+ Hwa, Wong Eng. School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia. Electronic address: EngHwa.Wong@taylors.edu.my.
+MeSH Subject Headings
+ Animals
+ *Anti-Obesity Agents/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Energy Metabolism/de [Drug Effects]
+ *Forkhead Box Protein O1/me [Metabolism]
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ Insulin Resistance
+ *Lipids/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Signal Transduction
+Keyword Heading
+ FoxO1
+ Glucose homeostasis
+ Obesity
+ Oxidative stress
+ Therapeutics
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Glucose production and the consumption of high levels of carbohydrate increase the chance of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced glucose homeostasis might form a strategy to prevent or cure diabetes and obesity. The activation and inhibition of glucose production is complicated due to the presence of many interfering pathways. These pathways can be viewed at the downstream level because they activate certain transcription factors, which include the Forkhead-O1 (FoxO1). This has been identified as a significant agent in the pancreas, liver, and adipose tissue, which is significant in the regulation of lipids and glucose. The objective of this review is to discuss the intersecting portrayal of FoxO1 and its parallel cross-talk which highlights obesity-induced insulin susceptibility in the discovery of a targeted remedy. The review also analyses current progress and provides a blueprint on therapeutics, small molecules, and extracts/phytochemicals which are explored at the pre-clinical level. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Blood Glucose). 0 (FOXO1 protein, human). 0 (Forkhead Box Protein O1). 0 (Hypoglycemic Agents). 0 (Lipids).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.ejphar.2020.173758
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Benchoula&issn=0014-2999&title=European+Journal+of+Pharmacology&atitle=FoxO1+signaling+as+a+therapeutic+target+for+type+2+diabetes+and+obesity.&volume=891&issue=&spage=173758&epage=&date=2021&doi=10.1016%2Fj.ejphar.2020.173758&pmid=33249079&sid=OVID:medline
+
+<1016>
+Unique Identifier
+ 33248350
+Title
+ Ultrasonographic features of ovarian morphology capture nutritional and metabolic influences on the reproductive axis: implications for biomarker development in ovulatory disorders. [Review]
+Source
+ Current Opinion in Biotechnology. 70:42-47, 2021 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vanden Brink H; Pea J; Lujan ME
+Authors Full Name
+ Vanden Brink, Heidi; Pea, Jeffrey; Lujan, Marla E.
+Institution
+ Vanden Brink, Heidi. Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
+ Pea, Jeffrey. Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
+ Lujan, Marla E. Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA. Electronic address: marla.lujan@cornell.edu.
+MeSH Subject Headings
+ Biomarkers
+ *Energy Metabolism
+ Female
+ Humans
+ Obesity/dg [Diagnostic Imaging]
+ *Obesity
+Abstract
+ Ultrasonographic imaging of ovarian morphology is used widely to inform reproductive health status in women. Metabolic disturbances induced by a negative energy balance (e.g. undernutrition) or positive energy balance (e.g. overnutrition, obesity) are known to drive or exacerbate reproductive dysfunction. Whether the utility of ultrasonographic metrics of ovarian morphology could be extended as biomarkers that detect and monitor the integration of metabolic and reproductive dysfunction is an emerging research area, and recent evidence is discussed. We note that unique variations in ovarian morphology emerge across the adiposity spectrum and highlight the potential for reproductive and metabolic 'tipping points' upon which such morphological variations may be detected on ultrasonography. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.copbio.2020.10.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vanden+Brink&issn=0958-1669&title=Current+Opinion+in+Biotechnology&atitle=Ultrasonographic+features+of+ovarian+morphology+capture+nutritional+and+metabolic+influences+on+the+reproductive+axis%3A+implications+for+biomarker+development+in+ovulatory+disorders.&volume=70&issue=&spage=42&epage=47&date=2021&doi=10.1016%2Fj.copbio.2020.10.008&pmid=33248350&sid=OVID:medline
+
+<1017>
+Unique Identifier
+ 33241460
+Title
+ Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes.
+Source
+ Diabetologia. 64(3):641-655, 2021 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lundqvist MH; Almby K; Wiklund U; Abrahamsson N; Kamble PG; Pereira MJ; Eriksson JW
+Author NameID
+ Lundqvist, Martin H; ORCID: https://orcid.org/0000-0001-9348-4603
+ Almby, Kristina; ORCID: https://orcid.org/0000-0002-7083-8912
+ Wiklund, Urban; ORCID: https://orcid.org/0000-0002-1313-0934
+ Abrahamsson, Niclas; ORCID: https://orcid.org/0000-0002-5428-8025
+ Kamble, Prasad G; ORCID: https://orcid.org/0000-0002-5627-8904
+ Pereira, Maria J; ORCID: https://orcid.org/0000-0001-5498-3899
+ Eriksson, Jan W; ORCID: https://orcid.org/0000-0002-2639-9481
+Authors Full Name
+ Lundqvist, Martin H; Almby, Kristina; Wiklund, Urban; Abrahamsson, Niclas; Kamble, Prasad G; Pereira, Maria J; Eriksson, Jan W.
+Institution
+ Lundqvist, Martin H. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
+ Almby, Kristina. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
+ Wiklund, Urban. Department of Radiation Sciences, Biomedical Engineering, Umea University, Umea, Sweden.
+ Abrahamsson, Niclas. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
+ Kamble, Prasad G. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
+ Pereira, Maria J. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
+ Eriksson, Jan W. Department of Medical Sciences, Uppsala University, Uppsala, Sweden. jan.eriksson@medsci.uu.se.
+MeSH Subject Headings
+ Adrenocorticotropic Hormone/bl [Blood]
+ Adult
+ *Autonomic Nervous System/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Blood Pressure
+ *Cardiovascular System/ir [Innervation]
+ *Central Nervous System/pp [Physiopathology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Female
+ Glucagon/bl [Blood]
+ Glucose Clamp Technique
+ Heart Rate
+ *Hormones/bl [Blood]
+ Humans
+ Hydrocortisone/bl [Blood]
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ ACTH
+ Central nervous system
+ Cortisol
+ Diabetes
+ Glucoregulatory hormones
+ Glucose
+ Insulin resistance
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/HYPOTHESIS: Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine response to various glucose concentrations in overweight and insulin-resistant individuals compared with lean individuals.
+
+ METHODS: Overweight/obese (HI, n = 15, BMI >=27.0 kg/m2) and lean (LO, n = 15, BMI <27.0 kg/m2) individuals without diabetes underwent hyperinsulinaemic euglycaemic-hypoglycaemic clamps and hyperglycaemic clamps on two separate occasions with measurements of hormones, Edinburgh Hypoglycaemic Symptom Scale (ESS) score and heart rate variability (HRV). Statistical methods included groupwise comparisons with Mann-Whitney U tests, multilinear regressions and linear mixed models between neuroendocrine responses and continuous metabolic variables.
+
+ RESULTS: During hypoglycaemic clamps, there was an elevated cortisol response in HI vs LO (median DELTAAUC 12,383 vs 4793 nmol/l x min; p = 0.050) and a significantly elevated adrenocorticotropic hormone (ACTH) response in HI vs LO (median DELTAAUC 437.3 vs 162.0 nmol/l x min; p = 0.021). When adjusting for clamp glucose levels, obesity (p = 0.033) and insulin resistance (p = 0.009) were associated with elevated glucagon levels. By contrast, parasympathetic activity was less suppressed in overweight individuals at the last stage of hypoglycaemia compared with euglycaemia (high-frequency power of HRV, p = 0.024). M value was the strongest predictor for the ACTH and PHF responses, independent of BMI and other variables. There was a BMI-independent association between the cortisol response and ESS score response (p = 0.024). During hyperglycaemic clamps, overweight individuals displayed less suppression of glucagon levels (median DELTAAUC -63.4% vs -73.0%; p = 0.010) and more suppression of sympathetic relative to parasympathetic activity (low-frequency/high-frequency power, p = 0.011).
+
+ CONCLUSIONS/INTERPRETATION: This study supports the hypothesis that altered responses of insulin-antagonistic hormones and the ANS to glucose fluctuations occur in overweight and insulin-resistant individuals, and that these responses are probably partly mediated by the CNS. Their potential role in development of type 2 diabetes needs to be addressed in future research. Graphical abstract.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hormones). 9002-60-2 (Adrenocorticotropic Hormone). 9007-92-5 (Glucagon). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs00125-020-05332-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lundqvist&issn=0012-186X&title=Diabetologia&atitle=Altered+hormonal+and+autonomic+nerve+responses+to+hypo-+and+hyperglycaemia+are+found+in+overweight+and+insulin-resistant+individuals+and+may+contribute+to+the+development+of+type+2+diabetes.&volume=64&issue=3&spage=641&epage=655&date=2021&doi=10.1007%2Fs00125-020-05332-z&pmid=33241460&sid=OVID:medline
+
+<1018>
+Unique Identifier
+ 33237483
+Title
+ Evaluation of the impact of age and adiposity on a multi-biomarker disease activity score before and after adjustment.
+Source
+ Clinical Rheumatology. 40(6):2419-2426, 2021 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baker JF; Curtis JR; Chernoff D; Flake DD 2nd; Sasso E; Long J; Taratuta E; George MD
+Author NameID
+ Baker, Joshua F; ORCID: http://orcid.org/0000-0003-0799-7563
+Authors Full Name
+ Baker, Joshua F; Curtis, Jeffrey R; Chernoff, David; Flake, Darl D 2nd; Sasso, Eric; Long, Jin; Taratuta, Elena; George, Michael D.
+Institution
+ Baker, Joshua F. Philadelphia VA Medical Center, Philadelphia, PA, USA. bakerjo@uphs.upenn.edu.
+ Baker, Joshua F. University of Pennsylvania, Philadelphia, PA, USA. bakerjo@uphs.upenn.edu.
+ Baker, Joshua F. Department of Epidemiology and Biostatistics, University of Pennsylvania, 5th Floor White Building, 3600 Spruce Street, Philadelphia, PA, 19104, USA. bakerjo@uphs.upenn.edu.
+ Curtis, Jeffrey R. Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Chernoff, David. Myriad Genetics and Laboratories, Salt Lake City, UT, USA.
+ Flake, Darl D 2nd. Myriad Genetics and Laboratories, Salt Lake City, UT, USA.
+ Sasso, Eric. Myriad Genetics and Laboratories, Salt Lake City, UT, USA.
+ Long, Jin. Stanford University, Palo Alto, CA, USA.
+ Taratuta, Elena. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
+ George, Michael D. University of Pennsylvania, Philadelphia, PA, USA.
+ George, Michael D. Department of Epidemiology and Biostatistics, University of Pennsylvania, 5th Floor White Building, 3600 Spruce Street, Philadelphia, PA, 19104, USA.
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ Adult
+ Aged
+ *Arthritis, Rheumatoid
+ Biomarkers
+ Body Mass Index
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity
+ Severity of Illness Index
+ Young Adult
+Keyword Heading
+ Biomarkers
+ Disease activity
+ Obesity
+ Rheumatoid arthritis: Adiposity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: We assessed the impact of adjustment of the multi-biomarker disease activity score (MBDA) for age, sex, and leptin, over the range of age and adiposity, and assessed relationships with clinical disease activity.
+
+ METHODS: Patients with RA, ages 18-75 years, were recruited from clinical practices and completed whole-body DXA to quantify fat mass indices (FMI, kg/m2). FMI Z-scores were calculated based on distributions in a reference population. Descriptive statistics described relationships between age, FMI Z-score, and the original MBDA and adjusted MBDA (aMBDA). Swollen joint counts (SJC) and the clinical disease activity index (CDAI) were assessed over MBDA categories.
+
+ RESULTS: There were 104 participants (50% female) with mean (SD) age of 56.1 (12.5) and body mass index (BMI) of 28.8 (6.9). Older age was associated with higher MBDA scores in men. The aMBDA was not associated with age. The original MBDA score was associated with FMI Z-score among women (Rho = 0.42, p = 0.002) but not men. The aMBDA was not associated with FMI Z-score in either women or men. The aMBDA score was lower than the original MBDA in the highest quartile of FMI in women and was higher in the lowest FMI quartiles in women and men. CDAI, SJC, and radiographic scores were similar across activity categories for the original MBDA score and aMBDA.
+
+ CONCLUSIONS: The aMBDA demonstrated reduced associations with adiposity, particularly among women. The aMBDA may be less likely to overestimate disease activity in women with greater adiposity and to underestimate disease activity in men and women with lesser adiposity. Key Points * Leptin adjustment of the MBDA score reduces the influence of adiposity, particularly among women. * Leptin adjustment results in significantly higher estimated disease activity in thin men and women. * The adjusted and unadjusted score correlate similarly with clinical disease activity measures.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs10067-020-05508-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baker&issn=0770-3198&title=Clinical+Rheumatology&atitle=Evaluation+of+the+impact+of+age+and+adiposity+on+a+multi-biomarker+disease+activity+score+before+and+after+adjustment.&volume=40&issue=6&spage=2419&epage=2426&date=2021&doi=10.1007%2Fs10067-020-05508-3&pmid=33237483&sid=OVID:medline
+
+<1019>
+Unique Identifier
+ 33237347
+Title
+ Obesity-related protein biomarkers for predicting breast cancer risk: an overview of systematic reviews. [Review]
+Source
+ Breast Cancer. 28(1):25-39, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu X; Zhang X; Hao Y; Li J
+Author NameID
+ Li, Jiayuan; ORCID: http://orcid.org/0000-0002-2920-1637
+Authors Full Name
+ Wu, Xueyao; Zhang, Xiaofan; Hao, Yu; Li, Jiayuan.
+Institution
+ Wu, Xueyao. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16 Ren Min Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Zhang, Xiaofan. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16 Ren Min Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Hao, Yu. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16 Ren Min Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China.
+ Li, Jiayuan. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16 Ren Min Nan Lu, Chengdu, 610041, Sichuan, People's Republic of China. lijiayuan73@163.com.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ Biomarkers/bl [Blood]
+ *Breast Neoplasms/ep [Epidemiology]
+ C-Reactive Protein/an [Analysis]
+ Female
+ Gonadal Steroid Hormones/bl [Blood]
+ Humans
+ Insulin/bl [Blood]
+ Insulin-Like Growth Factor Binding Protein 3/bl [Blood]
+ Insulin-Like Growth Factor I/an [Analysis]
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Postmenopause/bl [Blood]
+ Premenopause/bl [Blood]
+ Risk Assessment/mt [Methods]
+ Risk Factors
+ Systematic Reviews as Topic
+Keyword Heading
+ Biomarker
+ Breast cancer
+ Obesity
+ Overview of systematic reviews
+ Proteins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Based on the biological mechanisms underlying the obesity-breast cancer connections, potential protein biomarkers involved in breast cancer development have been identified, which may be helpful for the estimation of breast cancer risk. This study aimed to carry out a comprehensive overview of systematic reviews on circulating levels of obesity-related protein biomarkers for female breast cancer risk to provide a solid reference for potential breast cancer predictors.
+
+ METHODS: Comprehensive literature searches were conducted in MEDLINE, EMBASE and Cochrane Database of Systematic Reviews up to Dec 2019. The AMSTAR tool was used for the methodological quality assessment of the included systematic reviews. Evidence was reported narratively.
+
+ RESULTS: A total of 28 relevant systematic reviews which were mostly of moderate quality were included in the overview. Protein biomarkers relating to adipokines, insulin/insulin-like growth factor-1 (IGF-1) axis, inflammatory cytokines and sex hormones were investigated. Higher levels of circulating IGF-1, IGF-binding protein-3, leptin and resistin were found to be associated with an increased risk of premenopausal breast cancer; lower levels of circulating adiponectin and higher levels of circulating c-reactive protein, leptin, and resistin were found to be associated with an increased risk of postmenopausal breast cancer.
+
+ CONCLUSIONS: We found sufficient evidence on the positive associations between certain obesity-related protein biomarkers with pre- and/or postmenopausal breast cancer risk. These biomarkers could be used jointly as predictors, so as to build a comprehensive risk predictive score for female breast cancer.
+
+ PROSPERO REGISTRATION NUMBER: CRD42020175328.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Gonadal Steroid Hormones). 0 (IGF1 protein, human). 0 (IGFBP3 protein, human). 0 (Insulin). 0 (Insulin-Like Growth Factor Binding Protein 3). 67763-96-6 (Insulin-Like Growth Factor I). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs12282-020-01182-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=1340-6868&title=Breast+Cancer&atitle=Obesity-related+protein+biomarkers+for+predicting+breast+cancer+risk%3A+an+overview+of+systematic+reviews.&volume=28&issue=1&spage=25&epage=39&date=2021&doi=10.1007%2Fs12282-020-01182-0&pmid=33237347&sid=OVID:medline
+
+<1020>
+Unique Identifier
+ 33232646
+Title
+ Gut Microbiota and Serum Biomarker Analyses in Obese Patients Diagnosed with Diabetes and Hypothyroid Disorder.
+Source
+ Metabolic Syndrome & Related Disorders. 19(3):144-151, 2021 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tabasi M; Eybpoosh S; Sadeghpour Heravi F; Siadat SD; Mousavian G; Elyasinia F; Soroush A; Bouzari S
+Authors Full Name
+ Tabasi, Mohsen; Eybpoosh, Sana; Sadeghpour Heravi, Fatemah; Siadat, Seyed Davar; Mousavian, Ghazal; Elyasinia, Fezzeh; Soroush, Ahmadreza; Bouzari, Saeid.
+Institution
+ Tabasi, Mohsen. Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.
+ Tabasi, Mohsen. Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
+ Eybpoosh, Sana. Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.
+ Sadeghpour Heravi, Fatemah. Surgical Infection Research Group, Faculty of Medicine and Health Science, Macquarie University, Sydney, Australia.
+ Siadat, Seyed Davar. Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.
+ Mousavian, Ghazal. HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
+ Elyasinia, Fezzeh. Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
+ Soroush, Ahmadreza. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Bouzari, Saeid. Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.
+MeSH Subject Headings
+ Bacteria
+ Biomarkers
+ *Diabetes Mellitus
+ *Gastrointestinal Microbiome
+ Humans
+ Hypothyroidism/co [Complications]
+ Hypothyroidism/di [Diagnosis]
+ *Hypothyroidism
+ Insulin
+ Interleukin-10
+ Interleukin-6
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ RNA, Ribosomal, 16S/ge [Genetics]
+Keyword Heading
+ diabetes
+ gut microbiota
+ hypothyroid
+ obesity
+ serum biomarkers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Variations of serum biomarkers and bacterial diversity of the gastrointestinal tract in obese patients with diabetes or hypothyroid are poorly understood. The aim of this study was to provide recent findings in this regard. Methods: A total of 119 obese patients [17 with diabetes, 23 with hypothyroid, and 79 patients without either diabetes or hypothyroid (control)] were recruited in this study. Serum biomarkers such as biochemical, hormonal (insulin and glucagon), and cytokine levels [interleukin (IL)-6, IL-1beta, tumor necrosis factor-alpha, IL-10, and transforming growth factor beta-1 (TGF-beta1)] were measured under fasting conditions. Bacterial abundance of gut microbiota was also quantitated by real-time polymerase chain reaction using 16S rRNA gene-based specific primers. Results: Average value of blood sugar (P: 0.0184), hemoglobin A1c, insulin, homeostasis model assessment insulin resistance, TGF-beta 1, IL-6, IL-1beta, interferon gamma (Pfor each < 0.001), and phylum Actinobacteria [odds ratio (OR): 1.5, P: 0.032] was significantly higher in diabetic versus control group. In contrast, the levels of IL-10 (P < 0.001), Firmicutes (OR: 0.6, P: 0.058), and Akkermansia muciniphila (OR: 0.4, P: 0.053) were significantly lower in diabetic versus control group. However, there was no statistically significant difference between the values in hypothyroid versus control group either in crude or adjusted models. Conclusion: While there are some relationships between serum biomarkers or bacterial abundance with diabetes prediction in obese patients, this prognostication is less likely in obese patients with hypothyroid. Further investigation is warranted in the application of identified preclinical biomarkers in the diagnosis of diabetes or hypothyroid in obese patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 0 (Interleukin-6). 0 (RNA, Ribosomal, 16S). 130068-27-8 (Interleukin-10).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1089%2fmet.2020.0119
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tabasi&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Gut+Microbiota+and+Serum+Biomarker+Analyses+in+Obese+Patients+Diagnosed+with+Diabetes+and+Hypothyroid+Disorder.&volume=19&issue=3&spage=144&epage=151&date=2021&doi=10.1089%2Fmet.2020.0119&pmid=33232646&sid=OVID:medline
+
+<1021>
+Unique Identifier
+ 33221482
+Title
+ Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota.
+Source
+ Translational Research: The Journal Of Laboratory & Clinical Medicine. 231:113-123, 2021 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bishehsari F; Engen PA; Adnan D; Sarrafi S; Wilber S; Shaikh M; Green SJ; Naqib A; Giron LB; Abdel-Mohsen M; Keshavarzian A
+Authors Full Name
+ Bishehsari, Faraz; Engen, Phillip A; Adnan, Darbaz; Sarrafi, Shahram; Wilber, Sherry; Shaikh, Maliha; Green, Stefan J; Naqib, Ankur; Giron, Leila B; Abdel-Mohsen, Mohamed; Keshavarzian, Ali.
+Institution
+ Bishehsari, Faraz. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois. Electronic address: Faraz_Bishehsari@rush.edu.
+ Engen, Phillip A. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois.
+ Adnan, Darbaz. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois.
+ Sarrafi, Shahram. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois.
+ Wilber, Sherry. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois.
+ Shaikh, Maliha. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois.
+ Green, Stefan J. Genome Research Core, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois.
+ Naqib, Ankur. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois.
+ Giron, Leila B. The Wistar Institute, Philadelphia, Pennsylvania.
+ Abdel-Mohsen, Mohamed. The Wistar Institute, Philadelphia, Pennsylvania.
+ Keshavarzian, Ali. Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois; Department of Physiology, Rush University Medical Center, Chicago, Illinois; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
+MeSH Subject Headings
+ *Animal Husbandry
+ Animals
+ Biomarkers
+ Blood Glucose
+ Cadherins/me [Metabolism]
+ *Circadian Rhythm
+ Colon/me [Metabolism]
+ Food
+ *Gastrointestinal Microbiome
+ Glucose/me [Metabolism]
+ Insulin/bl [Blood]
+ Insulin/me [Metabolism]
+ Leptin/bl [Blood]
+ Leptin/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ *Obesity/me [Metabolism]
+ Random Allocation
+ Time Factors
+ *Weight Gain
+Abstract
+ Obesity has become a common rising health care problem, especially in "modern" societies. Obesity is considered a low-grade systemic inflammation, partly linked to leaky gut. Circadian rhythm disruption, a common habit in modern life, has been reported to cause gut barrier impairment. Abnormal time of eating, defined by eating close to or during rest time, is shown to cause circadian rhythm disruption. Here, using a non-obesogenic diet, we found that abnormal feeding time facilitated weight gain and induced metabolic dysregulation in mice. The effect of abnormal time of eating was associated with increased gut permeability, estimated by sucralose and/or lactulose ratio and disrupted intestinal barrier marker. Analysis of gut microbiota and their metabolites, as important regulators of barrier homeostasis, revealed that abnormal food timing reduced relative abundance of butyrate-producing bacteria, and the colonic butyrate level. Overall, our data supported that dysbiosis was characterized by increased intestinal permeability and decreased beneficial barrier butyrate-producing bacteria and/or metabolite to mechanistically link the time of eating to obesity. This data provides basis for noninvasive microbial-targeted interventions to improve intestinal barrier function as new opportunities for combating circadian rhythm disruption induced metabolic dysfunction. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cadherins). 0 (Insulin). 0 (Leptin). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.trsl.2020.11.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bishehsari&issn=1878-1810&title=Translational+Research%3A+The+Journal+Of+Laboratory+%26+Clinical+Medicine&atitle=Abnormal+food+timing+and+predisposition+to+weight+gain%3A+Role+of+barrier+dysfunction+and+microbiota.&volume=231&issue=&spage=113&epage=123&date=2021&doi=10.1016%2Fj.trsl.2020.11.007&pmid=33221482&sid=OVID:medline
+
+<1022>
+Unique Identifier
+ 33214697
+Title
+ Fibronectin type III domain-containing 5 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target.
+Source
+ Acta Pharmacologica Sinica. 42(9):1390-1400, 2021 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang X; Hu C; Wu HM; Ma ZG; Tang QZ
+Authors Full Name
+ Zhang, Xin; Hu, Can; Wu, Hai-Ming; Ma, Zhen-Guo; Tang, Qi-Zhu.
+Institution
+ Zhang, Xin. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
+ Zhang, Xin. Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.
+ Hu, Can. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
+ Hu, Can. Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.
+ Wu, Hai-Ming. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
+ Wu, Hai-Ming. Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.
+ Ma, Zhen-Guo. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. zhengma@whu.edu.cn.
+ Ma, Zhen-Guo. Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. zhengma@whu.edu.cn.
+ Tang, Qi-Zhu. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. qztang@whu.edu.cn.
+ Tang, Qi-Zhu. Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. qztang@whu.edu.cn.
+MeSH Subject Headings
+ *Biomarkers
+ *Cardiovascular Diseases/pp [Physiopathology]
+ Cardiovascular System/pp [Physiopathology]
+ Diabetes Mellitus
+ *Fibronectin Type III Domain/ph [Physiology]
+ Fibronectins
+ Heart/pp [Physiopathology]
+ Humans
+ *Metabolic Diseases/pp [Physiopathology]
+ Obesity
+Keyword Heading
+ FNDC5
+ biomarker
+ cardiovascular and metabolic diseases
+ therapeutic target
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cardiovascular and metabolic diseases are the leading causes of death and disability worldwide and impose a tremendous socioeconomic burden on individuals as well as the healthcare system. Fibronectin type III domain-containing 5 (FNDC5) is a widely distributed transmembrane glycoprotein that can be proteolytically cleaved and secreted as irisin to regulate glycolipid metabolism and cardiovascular homeostasis. In this review, we present the current knowledge on the predictive and therapeutic role of FNDC5 in a variety of cardiovascular and metabolic diseases, such as hypertension, atherosclerosis, ischemic heart disease, arrhythmia, metabolic cardiomyopathy, cardiac remodeling, heart failure, diabetes mellitus, and obesity. Copyright © 2020. CPS and SIMM.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FNDC5 protein, human). 0 (Fibronectins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1038%2fs41401-020-00557-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1671-4083&title=Acta+Pharmacologica+Sinica&atitle=Fibronectin+type+III+domain-containing+5+in+cardiovascular+and+metabolic+diseases%3A+a+promising+biomarker+and+therapeutic+target.&volume=42&issue=9&spage=1390&epage=1400&date=2021&doi=10.1038%2Fs41401-020-00557-5&pmid=33214697&sid=OVID:medline
+
+<1023>
+Unique Identifier
+ 33207279
+Title
+ Residual platelet reactivity in low-dose aspirin-treated patients with class 1 obesity.
+Source
+ Vascular Pharmacology. 136:106819, 2021 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee S; Eichelberger B; Kopp CW; Panzer S; Gremmel T
+Authors Full Name
+ Lee, Silvia; Eichelberger, Beate; Kopp, Christoph W; Panzer, Simon; Gremmel, Thomas.
+Institution
+ Lee, Silvia. Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
+ Eichelberger, Beate. Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
+ Kopp, Christoph W. Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
+ Panzer, Simon. Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
+ Gremmel, Thomas. Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Department of Internal Medicine I, Landesklinikum Mistelbach-Ganserndorf, Mistelbach, Austria. Electronic address: thomas.gremmel@meduniwien.ac.at.
+MeSH Subject Headings
+ Aged
+ Angioplasty/ae [Adverse Effects]
+ Angioplasty/is [Instrumentation]
+ *Angioplasty
+ *Aspirin/ad [Administration & Dosage]
+ Aspirin/ae [Adverse Effects]
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ *Blood Platelets/de [Drug Effects]
+ Blood Platelets/me [Metabolism]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/co [Complications]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/th [Therapy]
+ Dual Anti-Platelet Therapy
+ Female
+ Flow Cytometry
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ P-Selectin/bl [Blood]
+ *Platelet Aggregation/de [Drug Effects]
+ *Platelet Aggregation Inhibitors/ad [Administration & Dosage]
+ Platelet Aggregation Inhibitors/ae [Adverse Effects]
+ Platelet Function Tests
+ Platelet Glycoprotein GPIIb-IIIa Complex/me [Metabolism]
+ Stents
+ Thromboxane B2/aa [Analogs & Derivatives]
+ Thromboxane B2/bl [Blood]
+ Thromboxane B2/ur [Urine]
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ Body weight
+ Cardiovascular disease
+ Low-dose aspirin
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Recent data suggest a decreased clinical efficacy of low-dose aspirin in patients weighing >=70 kg. We therefore investigated the impact of body weight and class 1 obesity on thromboxane generation and platelet reactivity to arachidonic acid (AA) in 316 patients on dual antiplatelet therapy following angioplasty and stenting.
+
+ METHODS: Platelet surface expression of P-selectin and activated glycoprotein (GP) IIb/IIIa in response to AA were determined by flow cytometry as sensitive markers of platelet activation. Urinary 11-dehydro-thromboxane B2 (11-dehydro-TXB2) and serum TXB2 were measured by commercially-available immunoassays. On-treatment residual AA-inducible platelet aggregation was assessed by light transmission aggregometry (LTA), the VerifyNow aspirin assay and multiple electrode aggregometry (MEA).
+
+ RESULTS: Class 1 obesity was independently associated with increased platelet surface expression of P-selectin and activated GPIIb/IIIa, but not with urinary 11-dehydro-TXB2, serum TXB2, and on-treatment platelet aggregation by all assays. Of all measured parameters, only MEA showed a positive albeit very weak correlation with body weight (r = 0.13, p = 0.02). Furthermore, the results of all tests did not differ significantly between patients without and with a body weight >= 70 kg. After adjustment for age and diabetes by multivariate logistic regression analysis, the frequency of high-on treatment residual TXB2 generation and high on-treatment residual AA-inducible platelet reactivity (HRTG/HRPR) did not differ significantly between obese and non-obese patients.
+
+ CONCLUSION: Class 1 obesity is associated with enhanced platelet activation in response to AA in patients on dual antiplatelet therapy. This seems to be independent of cyclooxygenase-1 inhibition and does not translate into HRTG/HRPR. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (P-Selectin). 0 (Platelet Aggregation Inhibitors). 0 (Platelet Glycoprotein GPIIb-IIIa Complex). 0 (SELP protein, human). 54397-85-2 (Thromboxane B2). 67910-12-7 (11-dehydro-thromboxane B2). R16CO5Y76E (Aspirin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.vph.2020.106819
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=1537-1891&title=Vascular+Pharmacology&atitle=Residual+platelet+reactivity+in+low-dose+aspirin-treated+patients+with+class+1+obesity.&volume=136&issue=&spage=106819&epage=&date=2021&doi=10.1016%2Fj.vph.2020.106819&pmid=33207279&sid=OVID:medline
+
+<1024>
+Unique Identifier
+ 33201375
+Title
+ Comparison of metabolic and obesity biomarkers between adolescent and adult women with polycystic ovary syndrome.
+Source
+ Archives of Gynecology & Obstetrics. 303(3):739-749, 2021 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Medeiros SF; de Medeiros MAS; Barbosa BB; Yamamoto MMW; Maciel GAR
+Author NameID
+ de Medeiros, Sebastiao Freitas; ORCID: http://orcid.org/0000-0003-1292-2515
+Authors Full Name
+ de Medeiros, Sebastiao Freitas; de Medeiros, Matheus Antonio Souto; Barbosa, Bruna Barcelo; Yamamoto, Marcia Marly Winck; Maciel, Gustavo Arantes Rosa.
+Institution
+ de Medeiros, Sebastiao Freitas. Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiaba, MT, 78 043 306, Brazil. de.medeiros@terra.com.br.
+ de Medeiros, Sebastiao Freitas. Tropical Institute of Reproductive Medicine, Cuiaba, MT, Brazil. de.medeiros@terra.com.br.
+ de Medeiros, Matheus Antonio Souto. Tropical Institute of Reproductive Medicine, Cuiaba, MT, Brazil.
+ Barbosa, Bruna Barcelo. Tropical Institute of Reproductive Medicine, Cuiaba, MT, Brazil.
+ Yamamoto, Marcia Marly Winck. Tropical Institute of Reproductive Medicine, Cuiaba, MT, Brazil.
+ Maciel, Gustavo Arantes Rosa. Disciplina de Ginecologia, Departamento de Obstetricia E Ginecologia, Faculdade de Medicina de Sao Paulo, Hospital das Clinicas, Sao Paulo, Brazil.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Cholesterol, LDL/bl [Blood]
+ Female
+ Glucose Intolerance
+ Glucose Tolerance Test
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Metabolic Diseases/bl [Blood]
+ *Metabolic Diseases/co [Complications]
+ Metabolic Diseases/ep [Epidemiology]
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome/et [Etiology]
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Polycystic Ovary Syndrome/bl [Blood]
+ *Polycystic Ovary Syndrome/co [Complications]
+ Polycystic Ovary Syndrome/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ Adolescents
+ Adults
+ Biomarkers
+ Glucose intolerance
+ Metabolic syndrome
+ Polycystic ovary syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Knowledge of adolescent and adult phenotypes of women with polycystic ovary syndrome (PCOS) might drive opportune management. The aim of this study was to compare metabolic and obesity biomarkers between adolescent and adult women with PCOS.
+
+ METHODS: This observational study compared biomarkers of obesity and metabolism derangements between adolescent (n = 62) and adult (n = 248) women with PCOS. Predictors of metabolic syndrome (MS) were investigated using univariate and multivariate binary logistic regression analysis.
+
+ RESULTS: The postmenarcheal age of adolescents was 4.9 +/- 0.03 years. Systolic blood pressure was lower in adolescents than in adults (112.3 mmHg vs 117.0 mmHg, p = 0.001) Diastolic blood pressure was also lower in adolescents (70.7 mmHg vs 75.8 mmHg, p < 0.001). Glucose intolerance (12.0% vs 19.3%) and insulin resistance (18.2% vs 17.7%) were similar in both groups (p > 0.05, for comparisons). Impaired fasting glucose was lower in adolescents (1.8% vs 11.6%, p = 0.015). Total cholesterol and low-density lipoprotein cholesterol were lower in adolescents (p < 0.001). MS in adolescents and adults were found in 10.3% and 27.8%, respectively (p = 0.005). Visceral adiposity index (VAI) was a good predictor of MS in both adolescents (OR = 12.2), and adults (OR = 9.7).
+
+ CONCLUSIONS: Most biomarkers of glucose metabolism abnormalities were similar in adolescents and adults with PCOS. The prevalence of MS was lower in adolescents. VAI was a strong predictor of metabolic syndrome, both in adolescent and adult women with PCOS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, LDL). 0 (Insulin).
+Publication Type
+ Comparative Study. Journal Article. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs00404-020-05867-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Medeiros&issn=0932-0067&title=Archives+of+Gynecology+%26+Obstetrics&atitle=Comparison+of+metabolic+and+obesity+biomarkers+between+adolescent+and+adult+women+with+polycystic+ovary+syndrome.&volume=303&issue=3&spage=739&epage=749&date=2021&doi=10.1007%2Fs00404-020-05867-x&pmid=33201375&sid=OVID:medline
+
+<1025>
+Unique Identifier
+ 33188637
+Title
+ Modulation of the Gut Microbiome and Obesity Biomarkers by Lactobacillus Plantarum KC28 in a Diet-Induced Obesity Murine Model.
+Source
+ Probiotics & Antimicrobial Proteins. 13(3):677-697, 2021 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang E; Kim S; Park H; Park S; Ji Y; Todorov SD; Lim SD; Holzapfel WH
+Authors Full Name
+ Huang, Eunchong; Kim, Seulki; Park, Haryung; Park, Soyoung; Ji, Yosep; Todorov, Svetoslav Dimitrov; Lim, Sang-Dong; Holzapfel, Wilhelm Heinrich.
+Institution
+ Huang, Eunchong. Department of Advanced Green Energy and Environment, Handong Global University, Pohang, Gyeongbuk, 37554, South Korea.
+ Kim, Seulki. Korea Food Research Institute, Wanju, 55365, South Korea.
+ Park, Haryung. Department of Advanced Green Energy and Environment, Handong Global University, Pohang, Gyeongbuk, 37554, South Korea.
+ Park, Haryung. Techno-Business Center, HEM Inc, Pohang, 37673, South Korea.
+ Park, Soyoung. Department of Advanced Green Energy and Environment, Handong Global University, Pohang, Gyeongbuk, 37554, South Korea.
+ Park, Soyoung. Techno-Business Center, HEM Inc, Pohang, 37673, South Korea.
+ Ji, Yosep. Department of Advanced Green Energy and Environment, Handong Global University, Pohang, Gyeongbuk, 37554, South Korea.
+ Ji, Yosep. Techno-Business Center, HEM Inc, Pohang, 37673, South Korea.
+ Todorov, Svetoslav Dimitrov. Department of Advanced Green Energy and Environment, Handong Global University, Pohang, Gyeongbuk, 37554, South Korea.
+ Lim, Sang-Dong. Korea Food Research Institute, Wanju, 55365, South Korea.
+ Holzapfel, Wilhelm Heinrich. Department of Advanced Green Energy and Environment, Handong Global University, Pohang, Gyeongbuk, 37554, South Korea. wilhelm@woodapple.net.
+ Holzapfel, Wilhelm Heinrich. Techno-Business Center, HEM Inc, Pohang, 37673, South Korea. wilhelm@woodapple.net.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Diet, High-Fat
+ Disease Models, Animal
+ *Gastrointestinal Microbiome
+ *Lactobacillus plantarum
+ Mice
+ Mice, Inbred C57BL
+ *Obesity/th [Therapy]
+ Orlistat
+ Peroxisome Proliferator-Activated Receptors
+ *Probiotics
+Keyword Heading
+ Adipose tissue
+ Anti-obesity effect
+ Gut microbiome
+ Lactobacillus plantarum
+ Murine model
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Lactobacillus plantarum KC28 showed a beneficial (anti-obesity) effect in a diet-induced obese (DIO) C57BL/6 murine model receiving an intermediate high-fat diet (IF). This diet was selected for probiotic studies by prior comparisons of different combinations of basic (carbohydrate, protein and fat) components for optimized induction of dietary obesity in a murine model. Prior selection of Lact. plantarum strain KC28 was based on different physiological tests for safety and functionality including cell line adhesion and anti-adipogenic activity. The strain was administered at 5.0 x 109 CFU/mouse/day to the DIO mice (control mice received a normal diet). The anti-obesity effect of KC28 and the well-known probiotic strains Lact. rhamnosus GG (LGG) and Lact. plantarum 299v was assessed over 12 weeks. Xenical served as anti-obesity control. The high-fat diet groups receiving strains KC28 and LGG and the control Xenical group showed significant weight loss and notable changes in some obesity-related biomarkers in the liver (significant up-regulation of PGC1-alpha and CPT1-alpha only by KC28; p < 0.05) and mesenteric adipose tissue (significant down-regulation of ACOX-1, PPAR-gamma, and FAS; KC28 p < 0.001 for PPAR-gamma and FAS), compared with the IF control. Favourable changes in the studied biomarkers suggest a similar beneficial influence of Lact. plantarum KC28 on the alleviation of obesity comparable with that of the two well-studied probiotic strains, LGG and 299v. This probably resulted from a modulation in the cecal microbiota of the IF group by either probiotic strain, yet in a different manner, showing a highly significant increase in the families Desulfovibrionaceae and Lactobacillaceae only in the group receiving Lact. plantarum KC28.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peroxisome Proliferator-Activated Receptors). 95M8R751W8 (Orlistat).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs12602-020-09720-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=1867-1306&title=Probiotics+%26+Antimicrobial+Proteins&atitle=Modulation+of+the+Gut+Microbiome+and+Obesity+Biomarkers+by+Lactobacillus+Plantarum+KC28+in+a+Diet-Induced+Obesity+Murine+Model.&volume=13&issue=3&spage=677&epage=697&date=2021&doi=10.1007%2Fs12602-020-09720-0&pmid=33188637&sid=OVID:medline
+
+<1026>
+Unique Identifier
+ 33187870
+Title
+ Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.
+Source
+ Journal of Diabetes & its Complications. 35(1):107758, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al Dubayee M; Alshahrani A; Almalk M; Hakami A; Homoud B; Alzneidi N; Aldhalaan J; Aljbli G; Nasr A; Farahat AI; Aljada A
+Authors Full Name
+ Al Dubayee, Mohammed; Alshahrani, Awad; Almalk, Malak; Hakami, Alanoud; Homoud, Bareen; Alzneidi, Nowar; Aldhalaan, Jumana; Aljbli, Ghaidaa; Nasr, Amre; Farahat, Ahmed I; Aljada, Ahmad.
+Institution
+ Al Dubayee, Mohammed. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia; Department of Medicine, Ministry of National Guard Health Affairs (MNG-HA), Saudi Arabia. Electronic address: aldubayeemo@NGHA.med.sa.
+ Alshahrani, Awad. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia; Department of Medicine, Ministry of National Guard Health Affairs (MNG-HA), Saudi Arabia. Electronic address: alshahraniaw@ksau-hs.edu.sa.
+ Almalk, Malak. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. Electronic address: almalki130@ksau-hs.edu.sa.
+ Hakami, Alanoud. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. Electronic address: hakami134@ksau-hs.edu.sa.
+ Homoud, Bareen. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. Electronic address: homoud205@ksau-hs.edu.sa.
+ Alzneidi, Nowar. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. Electronic address: alzneidi207@ksau-hs.edu.sa.
+ Aldhalaan, Jumana. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. Electronic address: aldhalaan149@ksau-hs.edu.sa.
+ Aljbli, Ghaidaa. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. Electronic address: aljbli162@ksau-hs.edu.sa.
+ Nasr, Amre. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. Electronic address: nasra@ksau-hs.edu.sa.
+ Farahat, Ahmed I. Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
+ Aljada, Ahmad. Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. Electronic address: aaljadaa@Alfaisal.edu.
+MeSH Subject Headings
+ Biomarkers
+ Cellular Senescence
+ Cyclin-Dependent Kinase Inhibitor p16/ge [Genetics]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Diabetes Mellitus, Type 2
+ Gene Expression
+ Humans
+ Leukocytes, Mononuclear
+ Metformin/pd [Pharmacology]
+ Metformin/tu [Therapeutic Use]
+ Obesity
+ RNA, Messenger
+ Tumor Suppressor Protein p53/ge [Genetics]
+ U937 Cells
+Keyword Heading
+ Inflammation and cellular senescence
+ Insulin resistance
+ LMNA/C transcript variants
+ Mononuclear cells
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although there is increasing evidence showing that cell senescence is increased in circulating PBMC in type 2 diabetes mellitus (T2DM), the data are contradictory. This study examined several senescence biomarkers, including LMNA/C transcript variants, p16INK4a, p53, and p21Cip1/WAF, in PBMC of T2DM patients and the effect of Metformin on these senescence markers.
+
+ METHODS: Blood samples were obtained from 30 lean, 30 obese, 20 newly diagnosed type 2 diabetes mellitus (T2DM), and 30 T2DM on Metformin. PBMC were isolated and mRNA expression of the senescence biomarkers were quantified by RT-qPCR. The effect of ectopic expression of LMNA and LMNC in human monocytic cells lines (THP-1 and U937) on several inflammatory mediators were also examined.
+
+ RESULTS: LMNA expression was significantly higher in PBMC of obese and T2DM patients. LMNC expression was significantly inhibited in T2DM patients. LMNADELTA10 and Progerin mRNA expression was not detected in PBMC of all groups. Expression of p16INK4a, p21Cip1/WAF and p53 were inhibited significantly in T2DM. Metformin treatment reverted LMNA, LMNC, and p53 expression levels to normal levels. Upregulation of LMNA in monocytic THP-1 and U937 cell lines induced CD68, TNFalpha, CCL2, IL-6 and NOS2.
+
+ CONCLUSIONS: These data support the notion that LMNA may mediate senescence in PBMCs of T2DM by upregulating inflammatory pathways. Metformin may exert its anti-inflammatory property by modulation of senescence mediator LMNA. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cyclin-Dependent Kinase Inhibitor p16). 0 (RNA, Messenger). 0 (Tumor Suppressor Protein p53). 9100L32L2N (Metformin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.jdiacomp.2020.107758
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al+Dubayee&issn=1056-8727&title=Journal+of+Diabetes+%26+its+Complications&atitle=Metformin+alters+peripheral+blood+mononuclear+cells+%28PBMC%29+senescence+biomarkers+gene+expression+in+type+2+diabetic+patients.&volume=35&issue=1&spage=107758&epage=&date=2021&doi=10.1016%2Fj.jdiacomp.2020.107758&pmid=33187870&sid=OVID:medline
+
+<1027>
+Unique Identifier
+ 33180041
+Title
+ Longitudinal 15-year follow-up of women with former early puberty: abnormal metabolic profiles not associated with earlier age at onset of puberty, but associated with obesity.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 34(1):71-77, 2021 Jan 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jaruratanasirikul S; Satitpatanapan P; Sriplung H
+Authors Full Name
+ Jaruratanasirikul, Somchit; Satitpatanapan, Pitchaya; Sriplung, Hutcha.
+Institution
+ Jaruratanasirikul, Somchit. Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
+ Satitpatanapan, Pitchaya. Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
+ Sriplung, Hutcha. Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
+MeSH Subject Headings
+ Adult
+ Age of Onset
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Child
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ Longitudinal Studies
+ Menstruation
+ *Metabolome
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ *Puberty
+ Young Adult
+Keyword Heading
+ early puberty
+ menstrual cycle
+ metabolic profiles
+ reproductive function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In 2011, we described 104 girls who were diagnosed as early puberty (EP) during 2003-2005. In 2019-2020, the former EP women had been followed up 14 years after attaining their final height.
+
+ OBJECTIVE: To determine the reproductive function and metabolic profiles of former EP women.
+
+ STUDY DESIGN: Fifty-seven former EP women were evaluated for reproductive function and examined for health status. Blood samples were obtained for metabolic profiles of glucose, lipids and insulin, and testosterone levels.
+
+ RESULTS: In 2020, the average age of the study women was 22.9 +/- 1.7 years. The average height was 156.7 +/- 5.6 cm. The average weight had increased from 52.5 +/- 7.8 kg in 2011 to 58.5 +/- 11.1 kg in 2020 and average body mass index (BMI) from 21.4 +/- 2.9 to 23.8 +/- 4.0 kg/m2. Obesity (BMI>25 kg/m2) was found in 8.8% (five participants) in 2011 and had increased to 22.8% (13 participants) in 2020. Most participants (79%) had regular menstrual cycle. Of the 17 married women, 4 (23.5%) had 1-2 children. Dividing the participants into obese and nonobese groups, the average fasting plasma glucose, lipid profiles, and testosterone levels were similar in both groups. However, the average systolic blood pressure and the serum insulin levels and HOMA-IR assessments were significantly higher in the obese group than in the nonobese group.
+
+ CONCLUSION: The former EP women had normal menstruation and reproductive function. The former EP women with average BMI at the follow-up had normal metabolic profiles while those who later became obese had significantly higher systolic blood pressure, serum insulin, and HOMA-IR assessments. Copyright © 2020 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1515%2fjpem-2020-0353
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jaruratanasirikul&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Longitudinal+15-year+follow-up+of+women+with+former+early+puberty%3A+abnormal+metabolic+profiles+not+associated+with+earlier+age+at+onset+of+puberty%2C+but+associated+with+obesity.&volume=34&issue=1&spage=71&epage=77&date=2021&doi=10.1515%2Fjpem-2020-0353&pmid=33180041&sid=OVID:medline
+
+<1028>
+Unique Identifier
+ 33176332
+Title
+ Factors Influencing Total Serum IgE in Adults: The Role of Obesity and Related Metabolic Disorders.
+Source
+ International Archives of Allergy & Immunology. 182(3):220-228, 2021.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Carballo I; Alonso-Sampedro M; Gonzalez-Conde E; Sanchez-Castro J; Vidal C; Gude F; Gonzalez-Quintela A
+Authors Full Name
+ Carballo, Iago; Alonso-Sampedro, Manuela; Gonzalez-Conde, Elena; Sanchez-Castro, Juan; Vidal, Carmen; Gude, Francisco; Gonzalez-Quintela, Arturo.
+Institution
+ Carballo, Iago. Department of Internal Medicine, Complejo Hospitalario Universitario, Instituto de Investigaciones Sanitarias of Santiago de Compostela, Santiago de Compostela, Spain.
+ Alonso-Sampedro, Manuela. Department of Clinical Epidemiology, Complejo Hospitalario Universitario, Instituto de Investigaciones Sanitarias of Santiago de Compostela, Santiago de Compostela, Spain.
+ Gonzalez-Conde, Elena. Department of Internal Medicine, Complejo Hospitalario Universitario, Instituto de Investigaciones Sanitarias of Santiago de Compostela, Santiago de Compostela, Spain.
+ Sanchez-Castro, Juan. Primary Care Center, A Estrada, Santiago de Compostela, Spain.
+ Vidal, Carmen. Department of Allergy, Complejo Hospitalario Universitario, Instituto de Investigaciones Sanitarias of Santiago de Compostela, Santiago de Compostela, Spain.
+ Gude, Francisco. Department of Clinical Epidemiology, Complejo Hospitalario Universitario, Instituto de Investigaciones Sanitarias of Santiago de Compostela, Santiago de Compostela, Spain.
+ Gonzalez-Quintela, Arturo. Department of Internal Medicine, Complejo Hospitalario Universitario, Instituto de Investigaciones Sanitarias of Santiago de Compostela, Santiago de Compostela, Spain, arturo.gonzalez.quintela@sergas.es.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Age Factors
+ Aged
+ Aged, 80 and over
+ Allergens/im [Immunology]
+ *Biomarkers
+ Disease Susceptibility
+ Female
+ Humans
+ Hypersensitivity, Immediate/bl [Blood]
+ Hypersensitivity, Immediate/di [Diagnosis]
+ Hypersensitivity, Immediate/ep [Epidemiology]
+ Hypersensitivity, Immediate/im [Immunology]
+ *Immunoglobulin E/bl [Blood]
+ Immunoglobulin E/im [Immunology]
+ Male
+ Metabolic Diseases/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ Skin Tests
+ Young Adult
+Keyword Heading
+ Alcohol
+ Atopy
+ Immunoglobulin E
+ Metabolic syndrome
+ Obesity
+ Smoking
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: Few reports have investigated the association between metabolic abnormalities (obesity and related metabolic syndrome) and total serum IgE concentrations.
+
+ METHODS: This cross-sectional study included a random sample of 1,516 adult individuals (44.7% men, aged 18-91 years, median 52 years) from a single municipality in Spain. Serum IgE was measured in the ADVIA Centaur system. Atopy was defined by the presence of positive skin prick tests to a panel of common aeroallergens in the area. Body mass index and data related to the definition of metabolic syndrome were obtained from all participants. Alcohol consumption, smoking, and regular physical exercise were assessed by a questionnaire.
+
+ RESULTS: Atopy (present in 21.9% of 1,514 evaluable individuals) was the strongest factor determining serum IgE concentrations. Male sex and heavy alcohol drinking were independently associated with higher IgE concentrations, particularly in the non-atopic individuals. Body mass index was positively associated with IgE concentrations, independent of potential confounders, although the effect was only evident among non-atopic individuals. In that group, median IgE concentrations in normal-weight and obese individuals were 15 and 24 kU/L, respectively (p < 0.001); likewise, obesity was associated with high (>100 kU/L) IgE concentrations after adjusting for potential confounders (odds ratio: 1.79, 95% confidence interval: 1.26-2.56, p = 0.001). The presence of metabolic syndrome and its components, particularly abdominal obesity and hyperglycaemia, was also positively and independently associated with higher IgE concentrations in non-atopic individuals.
+
+ CONCLUSIONS: Obesity and metabolic syndrome components are associated with high total serum IgE concentrations, particularly in non-atopic individuals. Copyright © 2020 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Allergens). 0 (Biomarkers). 37341-29-0 (Immunoglobulin E).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1159%2f000510789
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Carballo&issn=1018-2438&title=International+Archives+of+Allergy+%26+Immunology&atitle=Factors+Influencing+Total+Serum+IgE+in+Adults%3A+The+Role+of+Obesity+and+Related+Metabolic+Disorders.&volume=182&issue=3&spage=220&epage=228&date=2021&doi=10.1159%2F000510789&pmid=33176332&sid=OVID:medline
+
+<1029>
+Unique Identifier
+ 33168209
+Title
+ Roux-en-Y gastric bypass decreases serum inflammatory markers and cardiovascular risk factors in obese diabetics.
+Source
+ Surgery. 169(3):539-542, 2021 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rossi I; Omotosho P; Poirier J; Spagnoli A; Torquati A
+Authors Full Name
+ Rossi, Isolina; Omotosho, Philip; Poirier, Jennifer; Spagnoli, Anna; Torquati, Alfonso.
+Institution
+ Rossi, Isolina. Department of Surgery, Carolinas Medical Center, Charlotte, NC.
+ Omotosho, Philip. Department of Surgery, Rush University Medical Center, Chicago, IL.
+ Poirier, Jennifer. Department of Surgery, Rush University Medical Center, Chicago, IL.
+ Spagnoli, Anna. Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL.
+ Torquati, Alfonso. Department of Surgery, Rush University Medical Center, Chicago, IL. Electronic address: Alfonso_Torquati@rush.edu.
+MeSH Subject Headings
+ Adult
+ *Biomarkers
+ Cardiovascular Diseases/et [Etiology]
+ Clinical Trials as Topic
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ Female
+ Gastric Bypass/mt [Methods]
+ *Gastric Bypass
+ *Heart Disease Risk Factors
+ Humans
+ *Inflammation Mediators/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/su [Surgery]
+ Prospective Studies
+Abstract
+ BACKGROUND: Obesity and type 2 diabetes mellitus are associated with elevated levels of inflammatory markers. This chronic inflammation is known to contribute to increased risk of cardiovascular disease in these populations. Laparoscopic Roux-en-Y gastric bypass is associated with a high rate of diabetes remission. We hypothesize that laparoscopic Roux-en-Y gastric bypass decreases systemic inflammatory markers and cardiovascular disease risk factors in obese diabetics.
+
+ METHODS: This was a single-institution prospective cohort study of 61 obese patients with type 2 diabetes mellitus. A total of 30 patients underwent laparoscopic Roux-en-Y gastric bypass surgery, and 31 patients underwent standard medical therapy with diabetes support and education. Collected data included preoperative and postoperative inflammatory biomarkers and clinical parameters.
+
+ RESULTS: Twelve months after undergoing laparoscopic Roux-en-Y gastric bypass, controlling for sex and age, there was a significant correlation between a change in interleukin-6 and a change in systolic blood pressure (Spearman r = 0.41, P = .03). Similarly, when sex and age were controlled for in the laparoscopic Roux-en-Y gastric bypass group, a statistically significant relationship remained between percent excess weight loss and change in interleukin-6 (P = .001).
+
+ CONCLUSION: A significant relationship exists between decreased systemic interleukin-6 levels and both excess weight loss and lowered systolic blood pressure after laparoscopic Roux-en-Y gastric bypass in obese patients with diabetes mellitus. These correlations may explain the decreased risk of cardiovascular disease after surgical weight reduction in this patient population. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.surg.2020.09.039
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rossi&issn=0039-6060&title=Surgery&atitle=Roux-en-Y+gastric+bypass+decreases+serum+inflammatory+markers+and+cardiovascular+risk+factors+in+obese+diabetics.&volume=169&issue=3&spage=539&epage=542&date=2021&doi=10.1016%2Fj.surg.2020.09.039&pmid=33168209&sid=OVID:medline
+
+<1030>
+Unique Identifier
+ 33160231
+Title
+ Race, socioeconomic status, and low-grade inflammatory biomarkers across the lifecourse: A pooled analysis of seven studies.
+Source
+ Psychoneuroendocrinology. 123:104917, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lam PH; Chiang JJ; Chen E; Miller GE
+Authors Full Name
+ Lam, Phoebe H; Chiang, Jessica J; Chen, Edith; Miller, Gregory E.
+Institution
+ Lam, Phoebe H. Department of Psychology, Northwestern University, Swift Hall, 2029 Sheridan Road, Evanston, IL, 60208, United States. Electronic address: phoebelam@u.northwestern.edu.
+ Chiang, Jessica J. Department of Psychology, Georgetown University, 306N White-Gravenor Hall, 37(th) and O Streets, NW, Washington DC, 20057, United States.
+ Chen, Edith. Department of Psychology, Northwestern University, Swift Hall, 2029 Sheridan Road, Evanston, IL, 60208, United States; Institute for Policy Research, Northwestern University, 2040 Sheridan Road, Evanston, IL, 60208, United States.
+ Miller, Gregory E. Department of Psychology, Northwestern University, Swift Hall, 2029 Sheridan Road, Evanston, IL, 60208, United States; Institute for Policy Research, Northwestern University, 2040 Sheridan Road, Evanston, IL, 60208, United States.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Child
+ Health Status Disparities
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/eh [Ethnology]
+ *Inflammation
+ Life Change Events
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/eh [Ethnology]
+ Race Factors
+ Racial Groups/sn [Statistics & Numerical Data]
+ *Racial Groups
+ *Social Class
+ Young Adult
+Keyword Heading
+ Adiposity
+ Health disparities
+ Lifecourse
+ Low-grade inflammation
+ Race
+ Socioeconomic status
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cardiovascular diseases are patterned by race and socioeconomic status, and chronic low-grade inflammation is proposed as a key underlying mechanism. Theories for how racial and socioeconomic disadvantages foster inflammation emphasize a lifecourse approach: social disadvantages enable chronic or repeated exposure to stressors, unhealthy behaviors, and environmental risks that accumulate across the lifecourse to increase low-grade inflammation. However, single samples rarely include multiple racial and socioeconomic groups that each span a wide age range, precluding examination of this proposition. To address this issue, the current study combined seven studies that measured C-reactive protein and interleukin-6, producing a pooled sample of 1650 individuals aged 11-60 years. We examined (a) whether race and socioeconomic disparities in inflammatory biomarkers vary across the lifecourse, (b) whether adiposity operates as a pathway leading to these disparities, and (c) whether any indirect pathways through adiposity also vary across the lifecourse. Relative to White individuals, Black individuals exhibited higher, whereas Asian individuals exhibited lower, levels of inflammatory biomarkers, and adiposity accounted for these racial differences. Similarly, lower socioeconomic status was associated with higher inflammatory biomarkers via elevated adiposity. Importantly, both racial and socioeconomic disparities, as well as their pathways via adiposity, widened across the lifecourse. This pattern suggests that the impact of social disadvantages compound with age, leading to progressively larger disparities in low-grade inflammation. More broadly, these findings highlight the importance of considering age when examining health disparities and formulating conceptual models that specify how and why disparities may vary across the lifecourse. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.psyneuen.2020.104917
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lam&issn=0306-4530&title=Psychoneuroendocrinology&atitle=Race%2C+socioeconomic+status%2C+and+low-grade+inflammatory+biomarkers+across+the+lifecourse%3A+A+pooled+analysis+of+seven+studies.&volume=123&issue=&spage=104917&epage=&date=2021&doi=10.1016%2Fj.psyneuen.2020.104917&pmid=33160231&sid=OVID:medline
+
+<1031>
+Unique Identifier
+ 33159639
+Title
+ Lupus anticoagulant and mortality in patients hospitalized for COVID-19.
+Source
+ Journal of Thrombosis & Thrombolysis. 52(1):85-91, 2021 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gazzaruso C; Mariani G; Ravetto C; Malinverni L; Tondelli E; Cerrone M; Sala V; Bevilacqua L; Altavilla T; Coppola A; Gallotti P
+Author NameID
+ Gazzaruso, Carmine; ORCID: http://orcid.org/0000-0001-9974-0735
+Authors Full Name
+ Gazzaruso, Carmine; Mariani, Giuseppe; Ravetto, Carolina; Malinverni, Laura; Tondelli, Elena; Cerrone, Maria; Sala, Vittorio; Bevilacqua, Luigi; Altavilla, Teodoro; Coppola, Adriana; Gallotti, Pietro.
+Institution
+ Gazzaruso, Carmine. Emergency Unit and Endocrinology Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Corso Pavia, 84, 27029, Vigevano, Italy. c.gazzaruso@gmail.com.
+ Gazzaruso, Carmine. Centre for Applied Clinical Research (Ce.R.C.A.), Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Corso Pavia, 84, 27029, Vigevano, Italy. c.gazzaruso@gmail.com.
+ Mariani, Giuseppe. Internal Medicine Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Vigevano, Italy.
+ Ravetto, Carolina. Internal Medicine Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Vigevano, Italy.
+ Malinverni, Laura. Internal Medicine Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Vigevano, Italy.
+ Tondelli, Elena. Internal Medicine Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Vigevano, Italy.
+ Cerrone, Maria. Emergency Unit and Endocrinology Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Corso Pavia, 84, 27029, Vigevano, Italy.
+ Sala, Vittorio. Internal Medicine Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Vigevano, Italy.
+ Bevilacqua, Luigi. Internal Medicine Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Vigevano, Italy.
+ Altavilla, Teodoro. Neurology Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Vigevano, Italy.
+ Coppola, Adriana. Centre for Applied Clinical Research (Ce.R.C.A.), Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Corso Pavia, 84, 27029, Vigevano, Italy.
+ Gallotti, Pietro. Internal Medicine Unit, Istituto Clinico "Beato Matteo" (Hospital Group San Donato), Vigevano, Italy.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ *COVID-19/bl [Blood]
+ COVID-19/di [Diagnosis]
+ *COVID-19/mo [Mortality]
+ COVID-19/th [Therapy]
+ Female
+ *Hospital Mortality
+ *Hospitalization
+ Humans
+ *Lupus Coagulation Inhibitor/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Oxygen/bl [Blood]
+ Respiration, Artificial
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ Troponin/bl [Blood]
+Keyword Heading
+ COVID-19
+ Intensive care
+ death
+ lupus anticoagulant
+ thrombosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Coronavirus disease 2019 (COVID-19) is characterized by a procoagulant state that can lead to fatal thromboembolic events. Several studies have documented a high prevalence of lupus anticoagulant that may at least partially explain the procoagulant profile of COVID-19. However, the association between lupus anticoagulant and thrombotic complications in COVID-19 is controversial and no study has specifically evaluated the impact of lupus anticoagulant on mortality. The aim of our study was to investigate the association between lupus anticoagulant and mortality in a large group of 192 consecutive patients hospitalized for COVID-19. Lupus anticoagulant was found in 95 patients (49.5%). No difference in the percentage of patients with lupus anticoagulant was observed between 130 survivors and 62 non-survivors (47.7 versus 53,2%; p = 0.4745). When the combined outcome of death or need for mechanical ventilation in survivors was taken into account, the difference in the prevalence of patients with lupus anticoagulant between the patients with the combined outcome (n = 76) and survivors who did not require mechanical ventilation (n = 116) was not significant (52.6% versus 47.4%; p = 0.4806). In multivariate analysis predictors of mortality or need for mechanical ventilation in survivors were obesity, low oxygen saturation and elevated troponin levels measured on admission. In conclusion, our study did not show any association of lupus anticoagulant with mortality and with need for mechanical ventilation in survivors. The role of obesity, low SaO2 and elevated troponin levels as predictors of a worse prognosis in patients hospitalized for COVID-19 was confirmed. Copyright © 2020. Springer Science+Business Media, LLC, part of Springer Nature.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lupus Coagulation Inhibitor). 0 (Troponin). S88TT14065 (Oxygen).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs11239-020-02335-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gazzaruso&issn=0929-5305&title=Journal+of+Thrombosis+%26+Thrombolysis&atitle=Lupus+anticoagulant+and+mortality+in+patients+hospitalized+for+COVID-19.&volume=52&issue=1&spage=85&epage=91&date=2021&doi=10.1007%2Fs11239-020-02335-w&pmid=33159639&sid=OVID:medline
+
+<1032>
+Unique Identifier
+ 33151749
+Title
+ The effect of circuit resistance training on plasma levels of amino acids, alpha-hydroxybutyrate, mannose, and urinary levels of glycine conjugated adducts in obese adolescent boys.
+Source
+ Applied Physiology, Nutrition, & Metabolism = Physiologie Appliquee, Nutrition et Metabolisme. 46(6):561-570, 2021 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rasooli SA; Fathi R; Golzar FA; Baghersalimi M
+Authors Full Name
+ Rasooli, Seyed Ali; Fathi, Rozita; Golzar, Farhad Ahmadi-Kani; Baghersalimi, Masoumeh.
+Institution
+ Rasooli, Seyed Ali. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Rasooli, Seyed Ali. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Fathi, Rozita. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Fathi, Rozita. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Golzar, Farhad Ahmadi-Kani. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Golzar, Farhad Ahmadi-Kani. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Baghersalimi, Masoumeh. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Baghersalimi, Masoumeh. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+MeSH Subject Headings
+ Adolescent
+ *Amino Acids/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ Body Composition
+ Body Mass Index
+ *Glycine/ur [Urine]
+ Humans
+ *Hydroxybutyrates/bl [Blood]
+ *Insulin Resistance
+ Male
+ *Mannose/bl [Blood]
+ *Obesity/me [Metabolism]
+ *Resistance Training
+Keyword Heading
+ acides amines a chaine ramifiee
+ adduits conjugues a la glycine
+ branched chain amino acids
+ circuit resistance training
+ entrainement contre resistance en circuit
+ glycine conjugated adducts
+ mannose
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Few studies have examined the improving effects of exercise on the association between metabolites of impaired protein metabolism and insulin resistance in obese children. Therefore, this study aims to investigate the effect of circuit resistance training (CRT) on plasma levels of amino acids, alpha-hydroxybutyrate (alpha-HB), mannose, and urinary levels of glycine conjugated adducts in obese adolescent boys. Forty obese adolescent boys (body mass index above the 95th percentile) with an age range of 14-17 years were randomly divided into the CRT group (n = 20) and control group (n = 20). The CRT program (3 times/week, 70%-80% of 1-repetition maximum) was performed for 8 weeks. The results indicated that the body composition and plasma levels of glucose, insulin resistance, valine, mannose, lysine, and the sum of branched-chain amino acids (BCAA) were decreased because of CRT. The plasma levels of asparagine, glycine, serine, and urinary levels of glycine conjugated adduct also increased in the CRT group. Although alpha-HB level decreased during CRT, it had no significant difference from that of the control group. It can be concluded that the improvement in obesity complications including insulin resistance in obese adolescent boys after CRT may be due to decrease in plasma levels of mannose and BCAA and increase urinary metabolites. Novelty: CRT improves glucose metabolism and insulin resistance in obese adolescent boys. CRT decreases plasma levels of mannose and BCAA and normalizes other amino acids. CRT increases urinary levels of glycine conjugated adducts.
+Registry Number/Name of Substance
+ 0 (Amino Acids). 0 (Biomarkers). 0 (Blood Glucose). 0 (Hydroxybutyrates). O0ADR0I4H5 (2-hydroxybutyric acid). PHA4727WTP (Mannose). TE7660XO1C (Glycine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1139%2fapnm-2020-0171
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rasooli&issn=1715-5312&title=Applied+Physiology%2C+Nutrition%2C+%26+Metabolism+%3D+Physiologie+Appliquee%2C+Nutrition+et+Metabolisme&atitle=The+effect+of+circuit+resistance+training+on+plasma+levels+of+amino+acids%2C+alpha-hydroxybutyrate%2C+mannose%2C+and+urinary+levels+of+glycine+conjugated+adducts+in+obese+adolescent+boys.&volume=46&issue=6&spage=561&epage=570&date=2021&doi=10.1139%2Fapnm-2020-0171&pmid=33151749&sid=OVID:medline
+
+<1033>
+Unique Identifier
+ 33146504
+Title
+ Biomarkers of left atrial overload in obese and nonobese patients with atrial fibrillation qualified for electrical cardioversion.
+Source
+ Kardiologia Polska. 79(3):269-276, 2021 03 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cichon M; Mizia-Szubryt M; Olszanecka-Glinianowicz M; Bozentowicz-Wikarek M; Owczarek AJ; Michalik R; Mizia-Stec K
+Authors Full Name
+ Cichon, Malgorzata; Mizia-Szubryt, Magdalena; Olszanecka-Glinianowicz, Magdalena; Bozentowicz-Wikarek, Maria; Owczarek, Aleksander J; Michalik, Rafal; Mizia-Stec, Katarzyna.
+Institution
+ Cichon, Malgorzata. 1st Department of Cardiology, Medical University of Silesia, Katowice, Poland
+ Mizia-Szubryt, Magdalena. 1st Department of Cardiology, Medical University of Silesia, Katowice, Poland
+ Olszanecka-Glinianowicz, Magdalena. Department of Pathophysiology, Medical University of Silesia, Katowice, Poland
+ Bozentowicz-Wikarek, Maria. Department of Pathophysiology, Medical University of Silesia, Katowice, Poland
+ Owczarek, Aleksander J. Department of Statistics, Department of Instrumental Analysis, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland
+ Michalik, Rafal. Private Practice "Fizjocox," Sosnowiec, Poland
+ Mizia-Stec, Katarzyna. 1st Department of Cardiology, Medical University of Silesia, Katowice, Poland
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Atrial Fibrillation/th [Therapy]
+ *Atrial Fibrillation
+ Atrial Function, Left
+ Biomarkers
+ *Electric Countershock
+ Humans
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Treatment Outcome
+Abstract
+ BACKGROUND: Biomarkers of left atrial (LA) overload are considered factors affecting the efficacy of atrial fibrillation (AF) treatment. Increasing obesity rates contribute to a growing number of obese patients qualified for electrical cardioversion (CVE). Biomarkers of left atrial (LA) overload are considered as factors influencing efficacy of atrial fibrillation (AF) treatment. The increasing rate of obesity contributes to obese patients constituting a significant group of subjects qualified to electrical cardioversion (CVE).
+
+ AIMS: The aim of the study was to evaluate serum concentrations of biomarkers of LA overload and their impact on the efficacy of CVE.
+
+ METHODS: A total of 82 patients with persistent AF who underwent successful CVE were prospectively enrolled in the study. The study population was divided into the obese group (OG) and the nonobese group (NOG). The serum levels of the following biomarkers were measured on the day of admission and at follow-up: high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-B-type natriuretic peptide, copeptin, galectin 3, growth differentiation factor 15 (GDF-15), and renalase.
+
+ RESULTS: Baseline and follow-up hs-CRP levels were increased in the OG compared with the NOG. Four-week CVE efficacy was 38.8% in the OG and 60.6% in the NOG. Time of the observation, allocation to the groups, and CVE outcomes showed no associations with most LA biomarkers during follow-up. Baseline concentrations of 2 biomarkers of LA overload were associated with clinical characteristics of the study group, that is, log10 serum GDF-15 and log10 serum renalase levels correlated positively with the CHA2DS2-VASc score.
+
+ CONCLUSIONS: Although obesity modifies the long-term efficacy of CVE, the OG and NOG did not differ significantly in most biomarkers of LA overload, except hs-CRP. The efficacy of CVE seems to be independent of the levels of biomarkers. A favorable procedure outcome did not affect their blood concentrations.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.33963%2fKP.15673
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cichon&issn=0022-9032&title=Kardiologia+Polska&atitle=Biomarkers+of+left+atrial+overload+in+obese+and+nonobese+patients+with+atrial+fibrillation+qualified+for+electrical+cardioversion.&volume=79&issue=3&spage=269&epage=276&date=2021&doi=10.33963%2FKP.15673&pmid=33146504&sid=OVID:medline
+
+<1034>
+Unique Identifier
+ 33135737
+Title
+ Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 106(2):e966-e981, 2021 01 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hagemann CA; Zhang C; Hansen HH; Jorsal T; Rigbolt KTG; Madsen MR; Bergmann NC; Heimburger SMN; Falkenhahn M; Theis S; Breitschopf K; Holm S; Hedegaard MA; Christensen MB; Vilsboll T; Holst B; Vrang N; Jelsing J; Knop FK
+Authors Full Name
+ Hagemann, Christoffer A; Zhang, Chen; Hansen, Henrik H; Jorsal, Tina; Rigbolt, Kristoffer T G; Madsen, Martin R; Bergmann, Natasha C; Heimburger, Sebastian M N; Falkenhahn, Mechthilde; Theis, Stefan; Breitschopf, Kristin; Holm, Stephanie; Hedegaard, Morten A; Christensen, Mikkel B; Vilsboll, Tina; Holst, Birgitte; Vrang, Niels; Jelsing, Jacob; Knop, Filip K.
+Institution
+ Hagemann, Christoffer A. Gubra Aps, Horsholm, Denmark.
+ Hagemann, Christoffer A. Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
+ Zhang, Chen. Gubra Aps, Horsholm, Denmark.
+ Hansen, Henrik H. Gubra Aps, Horsholm, Denmark.
+ Jorsal, Tina. Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
+ Rigbolt, Kristoffer T G. Gubra Aps, Horsholm, Denmark.
+ Madsen, Martin R. Gubra Aps, Horsholm, Denmark.
+ Bergmann, Natasha C. Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
+ Heimburger, Sebastian M N. Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
+ Heimburger, Sebastian M N. Steno Diabetes Center Copenhagen, Gentofte, Denmark.
+ Falkenhahn, Mechthilde. Sanofi Aventis, Frankfurt, Germany.
+ Theis, Stefan. Sanofi Aventis, Frankfurt, Germany.
+ Breitschopf, Kristin. Sanofi Aventis, Frankfurt, Germany.
+ Holm, Stephanie. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Hedegaard, Morten A. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Christensen, Mikkel B. Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
+ Christensen, Mikkel B. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Christensen, Mikkel B. Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
+ Vilsboll, Tina. Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
+ Vilsboll, Tina. Steno Diabetes Center Copenhagen, Gentofte, Denmark.
+ Vilsboll, Tina. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Holst, Birgitte. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Holst, Birgitte. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Vrang, Niels. Gubra Aps, Horsholm, Denmark.
+ Jelsing, Jacob. Gubra Aps, Horsholm, Denmark.
+ Knop, Filip K. Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
+ Knop, Filip K. Steno Diabetes Center Copenhagen, Gentofte, Denmark.
+ Knop, Filip K. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Knop, Filip K. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Antimicrobial Cationic Peptides/ge [Genetics]
+ *Antimicrobial Cationic Peptides/me [Metabolism]
+ Biomarkers/an [Analysis]
+ Blood Proteins/ge [Genetics]
+ *Blood Proteins/me [Metabolism]
+ Case-Control Studies
+ Cross-Over Studies
+ Double-Blind Method
+ Enteroendocrine Cells/me [Metabolism]
+ Enteroendocrine Cells/pa [Pathology]
+ Female
+ Follow-Up Studies
+ *Gastric Bypass/mt [Methods]
+ *Gastrointestinal Tract/me [Metabolism]
+ Humans
+ *Islets of Langerhans/me [Metabolism]
+ Islets of Langerhans/pa [Pathology]
+ Male
+ Obesity/pa [Pathology]
+ *Obesity/su [Surgery]
+ Peptide Fragments/ge [Genetics]
+ *Peptide Fragments/me [Metabolism]
+ Prognosis
+ Prospective Studies
+ *Transcriptome
+ Young Adult
+Keyword Heading
+ bariatric surgery
+ enteroendocrine cells
+ gut hormone
+ liver-expressed antimicrobial peptide 2
+ obesity
+ peptide fragment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: The mechanisms underlying Roux-en-Y gastric bypass (RYGB) surgery-induced weight loss and the immediate postoperative beneficial metabolic effects associated with the operation remain uncertain. Enteroendocrine cell (EEC) secretory function has been proposed as a key factor in the marked metabolic benefits from RYGB surgery.
+
+ OBJECTIVE: To identify novel gut-derived peptides with therapeutic potential in obesity and/or diabetes by profiling EEC-specific molecular changes in obese patients following RYGB-induced weight loss.
+
+ SUBJECTS AND METHODS: Genome-wide expression analysis was performed in isolated human small intestinal EECs obtained from 20 gut-biopsied obese subjects before and after RYGB. Targets of interest were profiled for preclinical and clinical metabolic effects.
+
+ RESULTS: Roux-en-Y gastric bypass consistently increased expression levels of the inverse ghrelin receptor agonist, liver-expressed antimicrobial peptide 2 (LEAP2). A secreted endogenous LEAP2 fragment (LEAP238-47) demonstrated robust insulinotropic properties, stimulating insulin release in human pancreatic islets comparable to the gut hormone glucagon-like peptide-1. LEAP238-47 showed reciprocal effects on growth hormone secretagogue receptor (GHSR) activity, suggesting that the insulinotropic action of the peptide may be directly linked to attenuation of tonic GHSR activity. The fragment was infused in healthy human individuals (n = 10), but no glucoregulatory effect was observed in the chosen dose as compared to placebo.
+
+ CONCLUSIONS: Small intestinal LEAP2 expression was upregulated after RYGB. The corresponding circulating LEAP238-47 fragment demonstrated strong insulinotropic action in vitro but failed to elicit glucoregulatory effects in healthy human subjects. Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Antimicrobial Cationic Peptides). 0 (Biomarkers). 0 (Blood Proteins). 0 (Peptide Fragments). 0 (liver-expressed antimicrobial peptide 2, human).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1210%2fclinem%2fdgaa803
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hagemann&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Identification+and+Metabolic+Profiling+of+a+Novel+Human+Gut-derived+LEAP2+Fragment.&volume=106&issue=2&spage=e966&epage=e981&date=2021&doi=10.1210%2Fclinem%2Fdgaa803&pmid=33135737&sid=OVID:medline
+
+<1035>
+Unique Identifier
+ 33111214
+Title
+ Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies. [Review]
+Source
+ Journal of Endocrinological Investigation. 44(6):1159-1174, 2021 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Catanzaro G; Filardi T; Sabato C; Vacca A; Migliaccio S; Morano S; Ferretti E
+Author NameID
+ Ferretti, E; ORCID: http://orcid.org/0000-0001-7265-6429
+Authors Full Name
+ Catanzaro, G; Filardi, T; Sabato, C; Vacca, A; Migliaccio, S; Morano, S; Ferretti, E.
+Institution
+ Catanzaro, G. Department of Experimental Medicine, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
+ Filardi, T. Department of Experimental Medicine, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
+ Sabato, C. Department of Experimental Medicine, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
+ Vacca, A. Department of Experimental Medicine, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
+ Migliaccio, S. Department of Movement, Human and Health Sciences, "Foro Italico" University of Rome, Rome, Italy.
+ Morano, S. Department of Experimental Medicine, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
+ Ferretti, E. Department of Experimental Medicine, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. elisabetta.ferretti@uniroma1.it.
+MeSH Subject Headings
+ *Bariatric Surgery/mt [Methods]
+ Biomarkers/bl [Blood]
+ *Circulating MicroRNA/bl [Blood]
+ *Diet Therapy/mt [Methods]
+ Gene Expression Profiling/mt [Methods]
+ Humans
+ Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ Obesity/px [Psychology]
+ Obesity/su [Surgery]
+ *Obesity
+ *Weight Loss/ph [Physiology]
+Keyword Heading
+ Bariatric surgery
+ Diet
+ Obesity
+ Obesity treatment
+ Weight loss
+ microRNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity, characterized by an increased amount of adipose tissue, is a metabolic chronic alteration which has reached pandemic proportion. Lifestyle changes are the first line therapy for obesity and a large variety of dietary approaches have demonstrated efficacy in promoting weight loss and improving obesity-related metabolic alterations. Besides diet and physical activity, bariatric surgery might be an effective therapeutic strategy for morbid obese patients. Response to weight-loss interventions is characterised by high inter-individual variability, which might involve epigenetic factors. microRNAs have critical roles in metabolic processes and their dysregulated expression has been reported in obesity.
+
+ AIM: The aim of this review is to provide a comprehensive overview of current studies evaluating changes in microRNA expression in obese patients undergoing lifestyle interventions or bariatric surgery.
+
+ RESULTS: A considerable number of studies have reported a differential expression of circulating microRNAs before and after various dietary and bariatric surgery approaches, identifying several candidate biomarkers of response to weight loss. Significant changes in microRNA expression have been observed at a tissue level as well, with entirely different patterns between visceral and subcutaneous adipose tissue. Interestingly, relevant differences in microRNA expression have emerged between responders and non-responders to dietary or surgical interventions. A wide variety of dysregulated microRNA target pathways have also been identified, helping to understand the pathophysiological mechanisms underlying obesity and obesity-related metabolic diseases.
+
+ CONCLUSIONS: Although further research is needed to draw firm conclusions, there is increasing evidence about microRNAs as potential biomarkers for weight loss and response to intervention strategies in obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Circulating MicroRNA).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs40618-020-01453-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Catanzaro&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Tissue+and+circulating+microRNAs+as+biomarkers+of+response+to+obesity+treatment+strategies.&volume=44&issue=6&spage=1159&epage=1174&date=2021&doi=10.1007%2Fs40618-020-01453-9&pmid=33111214&sid=OVID:medline
+
+<1036>
+Unique Identifier
+ 33098833
+Title
+ Liraglutide treatment and acylcarnitine profiles in Egyptian obese insulin-resistant females.
+Source
+ European Journal of Pharmacology. 891:173668, 2021 Jan 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hussein NA; Ebied SA; Nour HA; Zaki UK; El-Kotishy SM; Salem TM
+Authors Full Name
+ Hussein, Neveen A; Ebied, Samia A; Nour, Hoda A; Zaki, Usama K; El-Kotishy, Sahar M; Salem, Tarek M.
+Institution
+ Hussein, Neveen A. Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt. Electronic address: neveen.hussien@alexu.edu.eg.
+ Ebied, Samia A. Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
+ Nour, Hoda A. Physiology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
+ Zaki, Usama K. Clinical Genetics Department, Faculty of Medicine, Ain Shams University, Egypt.
+ El-Kotishy, Sahar M. Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
+ Salem, Tarek M. Internal Medicine Department, Endocrinology unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
+MeSH Subject Headings
+ Adult
+ *Anti-Obesity Agents/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Carnitine/aa [Analogs & Derivatives]
+ Carnitine/bl [Blood]
+ Case-Control Studies
+ Egypt
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ *Insulin Resistance
+ *Liraglutide/tu [Therapeutic Use]
+ Metabolomics
+ Middle Aged
+ Mitochondria/de [Drug Effects]
+ Mitochondria/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Time Factors
+ Treatment Outcome
+ *Weight Loss/de [Drug Effects]
+Keyword Heading
+ Acylcarnitines
+ Insulin-resistance
+ Liraglutide
+ Obese females
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Using metabolomics technique to investigate the response to liraglutide treatment produces helpful information regarding the effects of drug on metabolic regulation. This study tested whether loss of weight by liraglutide combined with decreasing acylcarnitines (AcylCNs) represent an effective strategy to improve insulin sensitivity in obese insulin-resistant females. AcylCN profiles by tandem mass spectrometry, plasma glycosylated hemoglobin, lactate, pyruvate, serum fasting glucose, creatinine, and insulin were assessed for obese insulin-resistant females before and after treatment with liraglutide for 3 months and non-obese females. All studied parameters in obese insulin-resistant females before treatment were significantly higher than control subjects except C0 and C3 levels which were significantly low. Liraglutide treatment was effective in weight loss, increased C0 and C3 levels and decreased values of all other studied parameters comparing with before treatment but still higher than control. However, creatinine level was unaffected by treatment. This study can conclude that circulating AcylCN profiles can reflect mitochondrial overload that happen in response to obesity. Also, AcylCNs can be used as markers for diagnosis of metabolic disorders. Liraglutide treatment leads to durable improvements in weight reduction and glycometabolic control and the utilization of intracellular glucose. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (acylcarnitine). 0 (hemoglobin A1c protein, human). 839I73S42A (Liraglutide). S7UI8SM58A (Carnitine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.ejphar.2020.173668
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hussein&issn=0014-2999&title=European+Journal+of+Pharmacology&atitle=Liraglutide+treatment+and+acylcarnitine+profiles+in+Egyptian+obese+insulin-resistant+females.&volume=891&issue=&spage=173668&epage=&date=2021&doi=10.1016%2Fj.ejphar.2020.173668&pmid=33098833&sid=OVID:medline
+
+<1037>
+Unique Identifier
+ 33092901
+Title
+ Endoscopic intragastric injection of botulinum toxin A in obese patients on bariatric surgery waiting lists: A randomised double-blind study (IntraTox study).
+Source
+ Clinical Nutrition. 40(4):1834-1842, 2021 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sanchez Torralvo FJ; Vazquez Pedreno L; Gonzalo Marin M; Tapia MJ; Lima F; Garcia Fuentes E; Garcia P; Moreno Ruiz J; Rodriguez Canete A; Valdes S; Olveira G
+Authors Full Name
+ Sanchez Torralvo, Francisco Jose; Vazquez Pedreno, Luis; Gonzalo Marin, Montserrat; Tapia, Maria Jose; Lima, Fuensanta; Garcia Fuentes, Eduardo; Garcia, Pilar; Moreno Ruiz, Javier; Rodriguez Canete, Alberto; Valdes, Sergio; Olveira, Gabriel.
+Institution
+ Sanchez Torralvo, Francisco Jose. UGC Endocrinologia y Nutricion, Hospital Regional Universitario de Malaga, Plaza del Hospital Civil, S/N, 29009, Malaga, Spain; Universidad de Malaga, Malaga, Spain; Instituto de Investigacion Biomedica de Malaga (IBIMA), Spain. Electronic address: fransancheztorralvo@gmail.com.
+ Vazquez Pedreno, Luis. UGC Aparato Digestivo, Unidad de Endoscopias. Hospital Regional Universitario de Malaga, Malaga, Spain.
+ Gonzalo Marin, Montserrat. UGC Endocrinologia y Nutricion, Hospital Regional Universitario de Malaga, Plaza del Hospital Civil, S/N, 29009, Malaga, Spain; Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigacion Biomedica de Malaga (IBIMA), Spain.
+ Tapia, Maria Jose. UGC Endocrinologia y Nutricion, Hospital Regional Universitario de Malaga, Plaza del Hospital Civil, S/N, 29009, Malaga, Spain; Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigacion Biomedica de Malaga (IBIMA), Spain.
+ Lima, Fuensanta. UGC Endocrinologia y Nutricion, Hospital Regional Universitario de Malaga, Plaza del Hospital Civil, S/N, 29009, Malaga, Spain.
+ Garcia Fuentes, Eduardo. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigacion Biomedica de Malaga (IBIMA), Spain.
+ Garcia, Pilar. UGC Aparato Digestivo, Unidad de Endoscopias. Hospital Regional Universitario de Malaga, Malaga, Spain.
+ Moreno Ruiz, Javier. UGC Cirugia General y Digestiva, Hospital Regional Universitario de Malaga, Malaga, Spain.
+ Rodriguez Canete, Alberto. UGC Cirugia General y Digestiva, Hospital Regional Universitario de Malaga, Malaga, Spain.
+ Valdes, Sergio. UGC Endocrinologia y Nutricion, Hospital Regional Universitario de Malaga, Plaza del Hospital Civil, S/N, 29009, Malaga, Spain; Universidad de Malaga, Malaga, Spain; Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigacion Biomedica de Malaga (IBIMA), Spain.
+ Olveira, Gabriel. UGC Endocrinologia y Nutricion, Hospital Regional Universitario de Malaga, Plaza del Hospital Civil, S/N, 29009, Malaga, Spain; Universidad de Malaga, Malaga, Spain; Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigacion Biomedica de Malaga (IBIMA), Spain.
+MeSH Subject Headings
+ Adult
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ Botulinum Toxins, Type A/ad [Administration & Dosage]
+ *Botulinum Toxins, Type A/tu [Therapeutic Use]
+ Double-Blind Method
+ *Endoscopy, Digestive System/mt [Methods]
+ Female
+ Follow-Up Studies
+ Humans
+ Injections
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Quality of Life
+ Satiation/de [Drug Effects]
+ Treatment Outcome
+ *Waiting Lists
+ Weight Loss/de [Drug Effects]
+Keyword Heading
+ Bariatric surgery
+ Botulinum toxin
+ Endoscopy
+ Obesity
+ Quality of life
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: Several studies have evaluated the effect of intragastric injection of botulinum toxin A to treat obesity, achieving mixed results. Our objective is to determine the effect of intragastric botulinum toxin A on weight loss, satiety, biomarkers, and quality of life of obese patients prior bariatric surgery.
+
+ METHODS: Design: single-centre, randomised, double-blind, placebo-controlled clinical trial in 52 obese patients on bariatric surgery waiting lists. Two-arm parallel: the treatment group was administered intragastric botulinum toxin A by endoscopy, whereas the control group was administered physiological saline solution. Weight loss was evaluated at weeks 2, 4, 8, 16, and 24, as well as changes in body composition, satiety (Visual analogue scale (VAS) and GCSI questionnaire), quality of life (GIQLI questionnaire), and biomarkers of satiety and appetite.
+
+ RESULTS: Weight loss at weeks 2, 4, 8, 16, and 24 after the endoscopy, with respect to the basal visit, was 0.6 +/- 2 kg, 0.4 +/- 2.7 kg, 0.4 +/- 3.1 kg, 0.2 +/- 4.5 kg, and 0.6 +/- 4.3 kg for the control group vs 1.9 +/- 2.1 kg, 2 +/- 2.6 kg, 2.8 +/- 4.1 kg, 3.5 +/- 5.3 kg, and 4.5 +/- 7 kg for the treatment group, respectively, being differences between groups significant at all times (p = 0.016, 0.031, 0.014, 0.021, and 0.023, respectively). Treatment group patients obtained a significantly higher score for GIQLI questionnaire compared with baseline (104.4 +/- 13.9 points vs 97.7 +/- 15.6 points; p = 0.024), showing a significant improvement in the section of subjective physical capacity. No significant differences were found regarding perception of satiety, or biomarkers of satiety and appetite.
+
+ CONCLUSIONS: Intragastric injection of botulinum toxin A is an effective and safe procedure to achieve a moderate weight loss and improve quality of life. Registered under clinicaltrialsregister.eu Identifier EudraCT number 2015-004391-29 https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-004391-29/ES. Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4-24-69 (Botulinum Toxins, Type A).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.clnu.2020.10.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sanchez+Torralvo&issn=0261-5614&title=Clinical+Nutrition&atitle=Endoscopic+intragastric+injection+of+botulinum+toxin+A+in+obese+patients+on+bariatric+surgery+waiting+lists%3A+A+randomised+double-blind+study+%28IntraTox+study%29.&volume=40&issue=4&spage=1834&epage=1842&date=2021&doi=10.1016%2Fj.clnu.2020.10.008&pmid=33092901&sid=OVID:medline
+
+<1038>
+Unique Identifier
+ 33070353
+Title
+ Peripheral leptin signaling persists in innate immune cells during diet-induced obesity.
+Source
+ Journal of Leukocyte Biology. 109(6):1131-1138, 2021 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Souza-Almeida G; Palhinha L; Liechocki S; da Silva Pereira JA; Reis PA; Dib PRB; Hottz ED; Gameiro J; Vallochi AL; de Almeida CJ; Castro-Faria-Neto H; Bozza PT; Maya-Monteiro CM
+Author NameID
+ Hottz, Eugenio D; ORCID: https://orcid.org/0000-0002-2201-1742
+ Bozza, Patricia T; ORCID: https://orcid.org/0000-0001-8349-9529
+ Maya-Monteiro, Clarissa Menezes; ORCID: https://orcid.org/0000-0001-6668-0940
+Authors Full Name
+ Souza-Almeida, Glaucia; Palhinha, Lohanna; Liechocki, Sally; da Silva Pereira, Jessica Aparecida; Reis, Patricia Alves; Dib, Paula Ribeiro Braga; Hottz, Eugenio D; Gameiro, Jacy; Vallochi, Adriana Lima; de Almeida, Cecilia Jacques; Castro-Faria-Neto, Hugo; Bozza, Patricia T; Maya-Monteiro, Clarissa Menezes.
+Institution
+ Souza-Almeida, Glaucia. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ Souza-Almeida, Glaucia. Current address: Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, Sao Paulo, Brazil.
+ Palhinha, Lohanna. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ Liechocki, Sally. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ da Silva Pereira, Jessica Aparecida. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ Reis, Patricia Alves. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ Dib, Paula Ribeiro Braga. Laboratory of Immunothrombosis, Department of Biochemistry, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
+ Dib, Paula Ribeiro Braga. Laboratory of Immunology, Infectious Disease and Obesity, Department of Parasitology, Microbiology and Immunology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
+ Hottz, Eugenio D. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ Hottz, Eugenio D. Laboratory of Immunothrombosis, Department of Biochemistry, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
+ Gameiro, Jacy. Laboratory of Immunology, Infectious Disease and Obesity, Department of Parasitology, Microbiology and Immunology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
+ Vallochi, Adriana Lima. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ de Almeida, Cecilia Jacques. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ Castro-Faria-Neto, Hugo. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ Bozza, Patricia T. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+ Maya-Monteiro, Clarissa Menezes. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cytokines/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ *Immunity, Innate
+ *Leptin/me [Metabolism]
+ Leukocytes/im [Immunology]
+ Leukocytes/me [Metabolism]
+ Mice
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Signal Transduction
+Keyword Heading
+ adipose tissue
+ high-fat diet
+ leptin signaling
+ leukocytes
+ macrophages
+ neutrophils
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Leptin is a pleiotropic adipokine that regulates immunometabolism centrally and peripherally. Obese individuals present increased levels of leptin in the blood and develop hypothalamic resistance to this adipokine. Here we investigated whether leptin effects on the periphery are maintained despite the hypothalamic resistance. We previously reported that leptin injection induces in vivo neutrophil migration and peritoneal macrophage activation in lean mice through TNF-alpha- and CXCL1-dependent mechanisms. However, leptin effects on leukocyte biology during obesity remain unclear. In this study, we investigated the in vivo responsiveness of leukocytes to i.p. injected leptin in mice with diet-induced obesity (DIO). After 14-16 wk, high-sucrose, high-fat diet (HFD)-fed mice showed hyperglycemia, hyperleptinemia, and dyslipidemia compared to normal-sucrose, normal-fat diet (ND). Exogenous leptin did not reduce food intake in DIO mice in contrast to control mice, indicating that DIO mice were centrally resistant to leptin. Regardless of the diet, we found increased levels of TNF-alpha and CXCL1 in the animals injected with leptin, alongside a pronounced neutrophil migration to the peritoneal cavity and enhanced biogenesis of lipid droplets in peritoneal macrophages. Supporting our in vivo results, data from ex vivo leptin stimulation experiments confirmed hypothalamic resistance in DIO mice, whereas bone marrow cells responded to leptin stimulation through mTOR signaling despite obesity. Altogether, our results show that leukocytes responded equally to leptin in ND- or HFD-fed mice. These results support a role for leptin in the innate immune response also in obesity, contributing to the inflammatory status that leads to the development of metabolic disease. Copyright ©2020 Society for Leukocyte Biology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Leptin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1002%2fJLB.3AB0820-092RR
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Souza-Almeida&issn=0741-5400&title=Journal+of+Leukocyte+Biology&atitle=Peripheral+leptin+signaling+persists+in+innate+immune+cells+during+diet-induced+obesity.&volume=109&issue=6&spage=1131&epage=1138&date=2021&doi=10.1002%2FJLB.3AB0820-092RR&pmid=33070353&sid=OVID:medline
+
+<1039>
+Unique Identifier
+ 33067796
+Title
+ Angiopoietin-like 8 (ANGPTL8) as a potential predictor of NAFLD in paediatric patients with Prader-Willi Syndrome.
+Source
+ Journal of Endocrinological Investigation. 44(7):1447-1456, 2021 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mele C; Crino A; Fintini D; Mai S; Convertino A; Bocchini S; Di Paolo P; Grugni G; Aimaretti G; Scacchi M; Marzullo P
+Author NameID
+ Marzullo, P; ORCID: http://orcid.org/0000-0003-3215-5747
+Authors Full Name
+ Mele, C; Crino, A; Fintini, D; Mai, S; Convertino, A; Bocchini, S; Di Paolo, P; Grugni, G; Aimaretti, G; Scacchi, M; Marzullo, P.
+Institution
+ Mele, C. Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
+ Mele, C. Division of General Medicine, Istituto Auxologico Italiano, IRCCS, San Giuseppe Hospital, Piancavallo, Verbania, Italy.
+ Crino, A. Reference Center for Prader-Willi Syndrome, Bambino Gesu Children's Hospital, Research Institute, Palidoro (Rome), Italy.
+ Fintini, D. Reference Center for Prader-Willi Syndrome, Bambino Gesu Children's Hospital, Research Institute, Palidoro (Rome), Italy.
+ Mai, S. Laboratory of Metabolic Research, Istituto Auxologico Italiano, IRCCS, San Giuseppe Hospital, Piancavallo, Verbania, Italy.
+ Convertino, A. Reference Center for Prader-Willi Syndrome, Bambino Gesu Children's Hospital, Research Institute, Palidoro (Rome), Italy.
+ Bocchini, S. Reference Center for Prader-Willi Syndrome, Bambino Gesu Children's Hospital, Research Institute, Palidoro (Rome), Italy.
+ Di Paolo, P. Radiology Unit, Bambino Gesu Children's Hospital, Research Institute, Palidoro (Rome), Italy.
+ Grugni, G. Division of Auxology and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, San Giuseppe Hospital, Piancavallo, Verbania, Italy.
+ Aimaretti, G. Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
+ Scacchi, M. Division of General Medicine, Istituto Auxologico Italiano, IRCCS, San Giuseppe Hospital, Piancavallo, Verbania, Italy.
+ Marzullo, P. Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. paolo.marzullo@med.uniupo.it.
+ Marzullo, P. Division of General Medicine, Istituto Auxologico Italiano, IRCCS, San Giuseppe Hospital, Piancavallo, Verbania, Italy. paolo.marzullo@med.uniupo.it.
+MeSH Subject Headings
+ Adolescent
+ *Angiopoietin-Like Protein 8/bl [Blood]
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Case-Control Studies
+ Child
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Obesity/pp [Physiopathology]
+ *Peptide Hormones/bl [Blood]
+ *Prader-Willi Syndrome/co [Complications]
+ Prognosis
+Keyword Heading
+ ANGPTL8
+ NAFLD
+ Prader-Willi syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Angiopoietin-like 8 (ANGPTL8) is a liver- and adipose tissue-produced protein that predicts non-alcoholic fatty liver disease (NAFLD) and altered metabolic homeostasis in the general population as well as in persons with common and genetic obesity, including the Prader-Willi syndrome (PWS). However, its metabolic correlate in paediatric patients with respect to PWS is unknown.
+
+ METHODS: This cross-sectional study investigated circulating ANGPTL8 and adipocytokines levels in 28 PWS and 28 age-, sex- and BMI-matched children and adolescents (age, 7.0-17.8y) in relation to NAFLD and metabolic homeostasis assessed by OGTT, paediatric metabolic index (PMI) and fatty liver index (FLI), liver ultrasonography (US), as well as dual-energy X-ray absorptiometry (DEXA) for analysis of fat (FM) and fat-free mass (FFM).
+
+ RESULTS: At the set level of significance, PWS children showed lower values of FFM (p < 0.01) but healthier insulin profiles (p < 0.01) and PMI values (p < 0.05) than matched controls. By US, the prevalence of NAFLD was similar between groups but less severe in PWS than controls. Analysis of ANGPTL8 levels showed no difference between groups, yet only in PWS ANGPTL8 levels were associated with ALT levels, FLI values and NAFLD. In stepwise multivariable regression analysis on merged data, ANGPTL8 levels were independently predicted by BMI SDS, leptin levels and NAFLD.
+
+ CONCLUSION: ANGPTL8 levels are similar in PWS and controls and, overall, they are directly associated with the presence and severity of NAFLD in patients with PWS.
+Registry Number/Name of Substance
+ 0 (ANGPTL8 protein, human). 0 (Angiopoietin-Like Protein 8). 0 (Biomarkers). 0 (Peptide Hormones).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs40618-020-01444-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mele&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Angiopoietin-like+8+%28ANGPTL8%29+as+a+potential+predictor+of+NAFLD+in+paediatric+patients+with+Prader-Willi+Syndrome.&volume=44&issue=7&spage=1447&epage=1456&date=2021&doi=10.1007%2Fs40618-020-01444-w&pmid=33067796&sid=OVID:medline
+
+<1040>
+Unique Identifier
+ 33037819
+Title
+ Brain Connectivity, and Hormonal and Behavioral Correlates of Sustained Weight Loss in Obese Patients after Laparoscopic Sleeve Gastrectomy.
+Source
+ Cerebral Cortex. 31(2):1284-1295, 2021 01 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hu Y; Ji G; Li G; Manza P; Zhang W; Wang J; Lv G; He Y; Zhang Z; Yuan K; von Deneen KM; Chen A; Cui G; Wang H; Wiers CE; Volkow ND; Nie Y; Zhang Y; Wang GJ
+Authors Full Name
+ Hu, Yang; Ji, Gang; Li, Guanya; Manza, Peter; Zhang, Wenchao; Wang, Jia; Lv, Ganggang; He, Yang; Zhang, Zhida; Yuan, Kai; von Deneen, Karen M; Chen, Antao; Cui, Guangbin; Wang, Huaning; Wiers, Corinde E; Volkow, Nora D; Nie, Yongzhan; Zhang, Yi; Wang, Gene-Jack.
+Institution
+ Hu, Yang. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ Ji, Gang. State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
+ Li, Guanya. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ Manza, Peter. Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
+ Zhang, Wenchao. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ Wang, Jia. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ Lv, Ganggang. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ He, Yang. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ Zhang, Zhida. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ Yuan, Kai. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ von Deneen, Karen M. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ Chen, Antao. Department of Psychology, Southwest University, Chongqing 400715, China.
+ Cui, Guangbin. Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, China.
+ Wang, Huaning. Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
+ Wiers, Corinde E. Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
+ Volkow, Nora D. Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
+ Nie, Yongzhan. State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
+ Zhang, Yi. Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
+ Wang, Gene-Jack. Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Brain/dg [Diagnostic Imaging]
+ Brain/me [Metabolism]
+ *Craving/ph [Physiology]
+ Female
+ *Gastrectomy/td [Trends]
+ Hormones/bl [Blood]
+ Humans
+ Laparoscopy/td [Trends]
+ Magnetic Resonance Imaging/td [Trends]
+ Male
+ *Nerve Net/dg [Diagnostic Imaging]
+ Nerve Net/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/dg [Diagnostic Imaging]
+ Obesity/su [Surgery]
+ *Weight Loss/ph [Physiology]
+Keyword Heading
+ bariatric surgery
+ cognitive control
+ eating behavior
+ functional/structural connectivity
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The biological mediators that support cognitive-control and long-term weight-loss after laparoscopic sleeve gastrectomy (LSG) remain unclear. We measured peripheral appetitive hormones and brain functional-connectivity (FC) using magnetic-resonance-imaging with food cue-reactivity task in 25 obese participants at pre, 1 month, and 6 month after LSG, and compared with 30 normal weight controls. We also used diffusion-tensor-imaging to explore whether LSG increases brain structural-connectivity (SC) of regions involved in food cue-reactivity. LSG significantly decreased BMI, craving for high-calorie food cues, ghrelin, insulin, and leptin levels, and increased self-reported cognitive-control of eating behavior. LSG increased FC between the right dorsolateral prefrontal cortex (DLPFC) and the pregenual anterior cingulate cortex (pgACC) and increased SC between DLPFC and ACC at 1 month and 6 month after LSG. Reduction in BMI correlated negatively with increased FC of right DLPFC-pgACC at 1 month and with increased SC of DLPFC-ACC at 1 month and 6 month after LSG. Reduction in craving for high-calorie food cues correlated negatively with increased FC of DLPFC-pgACC at 6 month after LSG. Additionally, SC of DLPFC-ACC mediated the relationship between lower ghrelin levels and greater cognitive control. These findings provide evidence that LSG improved functional and structural connectivity in prefrontal regions, which contribute to enhanced cognitive-control and sustained weight-loss following surgery. Copyright © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hormones).
+Publication Type
+ Journal Article. Research Support, N.I.H., Intramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1093%2fcercor%2fbhaa294
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hu&issn=1047-3211&title=Cerebral+Cortex&atitle=Brain+Connectivity%2C+and+Hormonal+and+Behavioral+Correlates+of+Sustained+Weight+Loss+in+Obese+Patients+after+Laparoscopic+Sleeve+Gastrectomy.&volume=31&issue=2&spage=1284&epage=1295&date=2021&doi=10.1093%2Fcercor%2Fbhaa294&pmid=33037819&sid=OVID:medline
+
+<1041>
+Unique Identifier
+ 33036941
+Title
+ Preoperative cardiac screening using NT-proBNP in obese patients 50 years and older undergoing bariatric surgery: a study of 310 consecutive patients.
+Source
+ Surgery for Obesity & Related Diseases. 17(1):64-71, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van Veldhuisen SL; van Woerden G; Hemels MEW; America YGCJ; de Boer RA; Rienstra M; van Veldhuisen DJ; Hazebroek EJ
+Authors Full Name
+ van Veldhuisen, Sophie L; van Woerden, Gijs; Hemels, Martin E W; America, Yves G C J; de Boer, Rudolf A; Rienstra, Michiel; van Veldhuisen, Dirk J; Hazebroek, Eric J.
+Institution
+ van Veldhuisen, Sophie L. Department of Surgery, Vitalys Clinic, Rijnstate Hospital, Arnhem, the Netherlands. Electronic address: svanveldhuisen@rijnstate.nl.
+ van Woerden, Gijs. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
+ Hemels, Martin E W. Department of Cardiology, Rijnstate Hospital, Arnhem, the Netherlands.
+ America, Yves G C J. Department of Cardiology, Rijnstate Hospital, Arnhem, the Netherlands.
+ de Boer, Rudolf A. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
+ Rienstra, Michiel. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
+ van Veldhuisen, Dirk J. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
+ Hazebroek, Eric J. Department of Surgery, Vitalys Clinic, Rijnstate Hospital, Arnhem, the Netherlands; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
+MeSH Subject Headings
+ *Bariatric Surgery
+ Biomarkers
+ *Cardiovascular Diseases/di [Diagnosis]
+ Cohort Studies
+ Female
+ Heart Disease Risk Factors
+ Humans
+ Male
+ Middle Aged
+ Natriuretic Peptide, Brain/bl [Blood]
+ Obesity
+ Peptide Fragments
+ Preoperative Care
+ Stroke Volume
+ *Ventricular Function, Left
+Keyword Heading
+ Bariatric surgery
+ Cardiac complications
+ Cardiovascular disease
+ Heart failure
+ N-terminal-pro hormone BNP
+ Preoperative evaluation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is associated with cardiovascular (CV) risk factors and diseases. Because bariatric surgery is increasingly performed in relatively elderly patients, a risk for pre- and postoperative CV complications exists.
+
+ OBJECTIVES: We aimed to assess the value of plasma N-terminal-probrain natriuretic peptide (NT-proBNP) as a CV screening tool.
+
+ SETTING: High-volume bariatric center.
+
+ METHODS: Between June 2019 and January 2020, all consecutive bariatric patients 50 years and older underwent preoperative NT-proBNP assessment in this cohort study to screen for CV disease. Patients with elevated NT-proBNP (>=125 pg/mL) were referred for further cardiac evaluation, including electrocardiography and echocardiography.
+
+ RESULTS: We included 310 consecutive patients (median age, 56 years; 79% female; body mass index = 43+/-6.5 kg/m2). A history of CV disease was present in 21% of patients, mainly atrial fibrillation (7%) and coronary artery disease (10%). A total of 72 patients (23%) had elevated NT-proBNP levels, and 67 of them underwent further cardiac workup. Of these 67 patients, electrocardiography (ECG) showed atrial fibrillation in 7 patients (10%). On echocardiography, 3 patients had left ventricular ejection fraction (LVEF) <40%, 9 patients had LVEF 40%-49%, and 13 patients had LVEF >=50% with structural and/or functional remodeling. In 2 patients, elevated NT-proBNP prompted workup leading to a diagnosis of coronary artery disease and consequent percutaneous coronary intervention in 1 patient.
+
+ CONCLUSIONS: Elevated NT-proBNP levels are present in 23% of patients 50 years and older undergoing bariatric surgery. In 37% of them, there was echocardiographic evidence for structural and/or functional remodeling. Further studies are needed to assess if these preliminary results warrant routine application of NT-proBNP to identify patients at risk for CV complications after bariatric surgery. Copyright © 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.soard.2020.08.036
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+Veldhuisen&issn=1550-7289&title=Surgery+for+Obesity+%26+Related+Diseases&atitle=Preoperative+cardiac+screening+using+NT-proBNP+in+obese+patients+50+years+and+older+undergoing+bariatric+surgery%3A+a+study+of+310+consecutive+patients.&volume=17&issue=1&spage=64&epage=71&date=2021&doi=10.1016%2Fj.soard.2020.08.036&pmid=33036941&sid=OVID:medline
+
+<1042>
+Unique Identifier
+ 33034707
+Title
+ The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial.
+Source
+ European Journal of Nutrition. 60(4):2111-2120, 2021 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stevens Y; Winkens B; Jonkers D; Masclee A
+Author NameID
+ Stevens, Yala; ORCID: http://orcid.org/0000-0003-4671-7739
+Authors Full Name
+ Stevens, Yala; Winkens, Bjorn; Jonkers, Daisy; Masclee, Adrian.
+Institution
+ Stevens, Yala. Department of Internal Medicine, Division of Gastroenterology-Hepatology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, P. O. Box 616, 6200, Maastricht, The Netherlands. yala.stevens@maastrichtuniversity.nl.
+ Stevens, Yala. BioActor BV, Maastricht, The Netherlands. yala.stevens@maastrichtuniversity.nl.
+ Winkens, Bjorn. Department of Methodology and Statistics, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
+ Jonkers, Daisy. Department of Internal Medicine, Division of Gastroenterology-Hepatology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, P. O. Box 616, 6200, Maastricht, The Netherlands.
+ Masclee, Adrian. Department of Internal Medicine, Division of Gastroenterology-Hepatology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, P. O. Box 616, 6200, Maastricht, The Netherlands.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Dietary Supplements
+ Double-Blind Method
+ Humans
+ Obesity/dt [Drug Therapy]
+ *Olea
+ Overweight/dt [Drug Therapy]
+ Plant Extracts
+Keyword Heading
+ Blood lipid profiles
+ Cardiovascular disease
+ Olive leaf extract
+ Overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Overweight and obesity are associated with many health problems, including cardiovascular disease (CVD). Evidence from previous studies has shown that extracts from olive leaves rich in olive phenolics are able to positively affect CVD risk factors, such as high blood pressure and dyslipidemia. The aim of this study was to investigate the effect of 8-week olive leaf extract (OLE) administration on blood lipid profiles in overweight/obese subjects with mildly elevated cholesterol levels.
+
+ METHODS: In this randomized, double-blind, placebo-controlled study, 77 healthy adult overweight/obese subjects (aged 56 +/- 10 years and BMI 29.0 +/- 2.7 kg/m2) with total cholesterol levels of 5.0-8.0 mmol/L (5.9 +/- 0.7 mmol/L) were randomly assigned to receive 500 mg of OLE (n = 39) or placebo (n = 38) for 8 weeks. In total, 74 subjects completed the entire study protocol. At baseline, after 4 weeks, and after 8 weeks of supplementation, blood lipid profiles, oxidized low-density lipoprotein (oxLDL), blood pressure, glucose, and insulin levels were assessed. In addition, liver function parameters were measured at baseline and after 8 weeks.
+
+ RESULTS: OLE supplementation did not significantly affect blood lipid levels after 4 weeks or after 8 weeks compared to placebo (all p > 0.05). For oxLDL, blood pressure, glucose, and insulin levels and liver function parameters, also no statistically significant differences were found between the two intervention groups (all p > 0.05).
+
+ CONCLUSIONS: Blood lipid profiles were not significantly affected by 8 weeks OLE supplementation in overweight/obese subjects with mildly elevated cholesterol levels.
+
+ TRIAL REGISTERED: The trial has been registered at ClinicalTrials.gov (NCT02990637).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Plant Extracts).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs00394-020-02397-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stevens&issn=1436-6207&title=European+Journal+of+Nutrition&atitle=The+effect+of+olive+leaf+extract+on+cardiovascular+health+markers%3A+a+randomized+placebo-controlled+clinical+trial.&volume=60&issue=4&spage=2111&epage=2120&date=2021&doi=10.1007%2Fs00394-020-02397-9&pmid=33034707&sid=OVID:medline
+
+<1043>
+Unique Identifier
+ 33031557
+Title
+ Effects of Intermittent Fasting or Calorie Restriction on Markers of Lipid Metabolism in Human Skeletal Muscle.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 106(3):e1389-e1399, 2021 03 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu B; Hutchison AT; Thompson CH; Lange K; Wittert GA; Heilbronn LK
+Authors Full Name
+ Liu, Bo; Hutchison, Amy T; Thompson, Campbell H; Lange, Kylie; Wittert, Gary A; Heilbronn, Leonie K.
+Institution
+ Liu, Bo. Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
+ Liu, Bo. Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
+ Hutchison, Amy T. Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
+ Hutchison, Amy T. Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
+ Thompson, Campbell H. Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
+ Lange, Kylie. Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
+ Wittert, Gary A. Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
+ Wittert, Gary A. Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
+ Heilbronn, Leonie K. Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
+ Heilbronn, Leonie K. Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ Caloric Restriction/mt [Methods]
+ *Fasting/ph [Physiology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Lipid Metabolism/ph [Physiology]
+ Middle Aged
+ Mitochondria, Muscle/me [Metabolism]
+ Muscle, Skeletal/ch [Chemistry]
+ *Muscle, Skeletal/me [Metabolism]
+ Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ Overweight/dh [Diet Therapy]
+ Overweight/me [Metabolism]
+ Oxidation-Reduction
+ Weight Loss/ph [Physiology]
+Keyword Heading
+ calorie restriction
+ intermittent fasting
+ lipid metabolism
+ mitochondria
+ muscle
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Impaired lipid metabolism is linked with obesity-associated insulin resistance, which may be reversed by caloric restriction (CR).
+
+ OBJECTIVE: In a secondary analysis of a randomized controlled trial, we compared the effects of intermittent fasting (IF) and CR on markers of lipid metabolism in muscle.
+
+ DESIGN: Seventy-six women (body mass index, 25-40 kg/m2) were randomly assigned to 1 of 3 diets for 8 weeks and provided foods at 70% (CR70 and IF70) or 100% (IF100) of energy requirements. IF groups ate breakfast prior to a 24-hour fast on 3 nonconsecutive days per week. On nonfasting days, IF70 ate at 100% and IF100 ate at 145% of energy requirements to achieve the prescribed target. Weight, body composition, insulin sensitivity by clamp, nonesterified fatty acids (NEFAs), beta-hydroxybutyrate (BHB), and markers of lipid metabolism and oxidative stress in muscle by quantitative polymerase chain reaction were measured at baseline and week 8 following a 12-hour overnight fast (all groups) and 24-hour fast (IF groups).
+
+ RESULTS: IF70 resulted in greater weight and fat loss and reduced NEFAs vs CR70 and IF100 after an overnight fast. IF70 and IF100 induced a greater reduction only in mRNA levels of antioxidant enzymes glutathione peroxidase 1 (GPX1), superoxide dismutase 1, soluble (SOD1), and SOD2 vs CR70. Fasting for 24 hours increased NEFAs and BHB in IF groups, but impaired insulin sensitivity and increased PLIN5 mRNA levels.
+
+ CONCLUSIONS: In comparison to CR, IF did not increase markers of lipid metabolism in muscle, but reduced expression of antioxidant enzymes. However, fasting-induced insulin resistance was detected, alongside increased PLIN5 expression, potentially reflecting transient lipid storage. Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1210%2fclinem%2fdgaa707
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Effects+of+Intermittent+Fasting+or+Calorie+Restriction+on+Markers+of+Lipid+Metabolism+in+Human+Skeletal+Muscle.&volume=106&issue=3&spage=e1389&epage=e1399&date=2021&doi=10.1210%2Fclinem%2Fdgaa707&pmid=33031557&sid=OVID:medline
+
+<1044>
+Unique Identifier
+ 33012244
+Title
+ Effects of descending or ascending stair exercise on body composition, insulin sensitivity, and inflammatory markers in young Chinese women with obesity: A randomized controlled trial.
+Source
+ Journal of Sports Sciences. 39(5):496-502, 2021 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chow BC; Li S; Zhu X; Jiao J; Quach B; Baker JS; Zhang H
+Author NameID
+ Chow, Bik Chu; ORCID: https://orcid.org/0000-0002-0282-3743
+ Zhu, Xiangui; ORCID: https://orcid.org/0000-0002-4483-4862
+ Zhang, Haifeng; ORCID: https://orcid.org/0000-0002-9930-9993
+Authors Full Name
+ Chow, Bik Chu; Li, Shuoqi; Zhu, Xiangui; Jiao, Jiao; Quach, Binh; Baker, Julien S; Zhang, Haifeng.
+Institution
+ Chow, Bik Chu. Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Hong Kong, China.
+ Chow, Bik Chu. Department of Sport and Physical Education, Hong Kong Baptist University, Hong Kong, China.
+ Li, Shuoqi. Physical Education College, Hebei Normal University, Shijiazhuang, China.
+ Li, Shuoqi. School of Health Sciences, University Sains Malaysia, Kota Bahru, Malaysia.
+ Zhu, Xiangui. Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Hong Kong, China.
+ Zhu, Xiangui. Physical Education College, Hebei Normal University, Shijiazhuang, China.
+ Jiao, Jiao. Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Hong Kong, China.
+ Quach, Binh. Department of Sport and Physical Education, Hong Kong Baptist University, Hong Kong, China.
+ Baker, Julien S. Department of Sport and Physical Education, Hong Kong Baptist University, Hong Kong, China.
+ Zhang, Haifeng. Physical Education College, Hebei Normal University, Shijiazhuang, China.
+ Zhang, Haifeng. Hebei Provincial Key Lab of Measurement and Evaluation in Human Movement and Bio-Information, Hebei Normal University, Shijiazhuang, China.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Body Composition/ph [Physiology]
+ China
+ Female
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ *Interleukin-6/bl [Blood]
+ *Obesity/th [Therapy]
+ *Stair Climbing/ph [Physiology]
+ *Tumor Necrosis Factor-alpha/bl [Blood]
+ Young Adult
+Keyword Heading
+ Descending stair exercise
+ ascending stair exercise
+ body composition
+ insulin sensitivity
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We examined the effects of descending (DSE) or ascending (ASE) stair exercise on body composition, insulin sensitivity, and inflammatory markers in young Chinese women with obesity. Thirty-six participants were randomly assigned into three groups DSE, ASE and a control group. The DSE and ASE groups performed three sessions of stair walking per week for 12 weeks with a gradual increase in repetitions. Following the exercise interventions, body composition related variables obtained by Dual-energy X-ray absorptiometry scans significantly decreased. Abdominal fat decreased in the DSE group only. Moreover, Insulin sensitivity improved significantly 3.5-fold in the DSE group compared with ASE group (insulin: -33.2% vs. -9.8%, homoeostasis model assessment for insulin resistance: -35.6% vs. -10.8%). Pro-inflammatory factors showed significant decreases in tumour necrosis factor-alpha (TNF-alpha) (-39.9% vs. -23.2%) for both intervention groups. The reduction in TNF-alpha concentrations in the DSE group was significantly different compared to the other two groups. Interleukin-6 significantly decreased in both exercise protocols. Our results show that 12-weeks induced stair walking improved body composition parameters in Chinese females with obesity. The results also demonstrate the superiority of the DSE protocol for improving insulin sensitivity. These findings may be attributable to the decreases observed in TNF- alpha levels.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1080%2f02640414.2020.1829362
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chow&issn=0264-0414&title=Journal+of+Sports+Sciences&atitle=Effects+of+descending+or+ascending+stair+exercise+on+body+composition%2C+insulin+sensitivity%2C+and+inflammatory+markers+in+young+Chinese+women+with+obesity%3A+A+randomized+controlled+trial.&volume=39&issue=5&spage=496&epage=502&date=2021&doi=10.1080%2F02640414.2020.1829362&pmid=33012244&sid=OVID:medline
+
+<1045>
+Unique Identifier
+ 33009195
+Title
+ Weight Loss for Obese Prostate Cancer Patients on Androgen Deprivation Therapy.
+Source
+ Medicine & Science in Sports & Exercise. 53(3):470-478, 2021 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wilson RL; Newton RU; Taaffe DR; Hart NH; Lyons-Wall P; Galvao DA
+Authors Full Name
+ Wilson, Rebekah L; Newton, Robert U; Taaffe, Dennis R; Hart, Nicolas H; Lyons-Wall, Philippa; Galvao, Daniel A.
+Institution
+ Lyons-Wall, Philippa. School of Medical and Health Sciences, Edith Cowan University, Perth, WA, AUSTRALIA.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Adipose Tissue
+ *Adiposity
+ Aged
+ Aged, 80 and over
+ *Androgen Antagonists/ae [Adverse Effects]
+ Biomarkers/bl [Blood]
+ Cardiorespiratory Fitness/ph [Physiology]
+ Energy Intake
+ *Exercise/ph [Physiology]
+ Humans
+ Leptin/bl [Blood]
+ Male
+ Middle Aged
+ Muscle Strength/ph [Physiology]
+ Obesity/ci [Chemically Induced]
+ Obesity/dh [Diet Therapy]
+ *Obesity/th [Therapy]
+ Oxygen Consumption
+ Prospective Studies
+ *Prostatic Neoplasms/dt [Drug Therapy]
+ Resistance Training/mt [Methods]
+ Testosterone/bl [Blood]
+ Time Factors
+ *Weight Loss
+Abstract
+ PURPOSE: Excess fat mass (FM) contributes to poor prostate cancer (PCa) prognosis and comorbidity. However, FM gain is a common side effect of androgen deprivation therapy (ADT). We examined the efficacy of a 12-wk weight loss intervention to reduce FM and maintain lean mass (LM) in ADT-treated obese PCa patients.
+
+ METHODS: Fourteen ADT-treated obese PCa patients (72 +/- 9 yr, 39.7% +/- 5.4% body fat) were recruited for a self-controlled prospective study, with 11 completing the 6-wk control period, followed by a 12-wk intervention comprising 300 min.wk-1 of exercise including supervised resistance training and home-based aerobic exercise, and dietitian consultations advising a daily energy deficit (2100-4200 kJ) and protein supplementation. Body composition was assessed by dual x-ray absorptiometry. Secondary outcomes included muscle strength (one-repetition maximum), cardiorespiratory fitness (maximal oxygen consumption), and blood biomarkers.
+
+ RESULTS: There were no significant changes during the control period. Patients attended 89% of supervised exercise sessions and 100% of dietitian consultations. No changes in physical activity or energy intake were observed. During the intervention, patients experienced significant reductions in weight (-2.8 +/- 3.2 kg, P = 0.016), FM (-2.8 +/- 2.6 kg, P < 0.001), and trunk FM (-1.8 +/- 1.4 kg, P < 0.001), with LM preserved (-0.05 +/- 1.6 kg, P = 0.805). Muscle strength (4.6%-24.7%, P < 0.010) and maximal oxygen consumption (3.5 +/- 4.7 mL.min-1.kg-1, P = 0.041) significantly improved. Leptin significantly decreased (-2.2 (-2.7 to 0.5) ng.mL-1, P = 0.016) with no other changes in blood biomarkers such as testosterone and lipids (P = 0.051-0.765); however, C-reactive protein (rs = -0.670, P = 0.024) and triglycerides (r = -0.667, P = 0.025) were associated with individual changes in LM.
+
+ CONCLUSIONS: This study shows preliminary efficacy for an exercise and nutrition weight loss intervention to reduce FM, maintain LM, and improve muscle strength and cardiorespiratory fitness in ADT-treated obese PCa patients. The change in body composition may affect blood biomarkers associated with obesity and PCa progression; however, further research is required. Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.
+Registry Number/Name of Substance
+ 0 (Androgen Antagonists). 0 (Biomarkers). 0 (Leptin). 3XMK78S47O (Testosterone).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1249%2fMSS.0000000000002509
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wilson&issn=0195-9131&title=Medicine+%26+Science+in+Sports+%26+Exercise&atitle=Weight+Loss+for+Obese+Prostate+Cancer+Patients+on+Androgen+Deprivation+Therapy.&volume=53&issue=3&spage=470&epage=478&date=2021&doi=10.1249%2FMSS.0000000000002509&pmid=33009195&sid=OVID:medline
+
+<1046>
+Unique Identifier
+ 32990516
+Title
+ Is Neck Circumference As Reliable As Waist Circumference for Determining Metabolic Syndrome?.
+Source
+ Metabolic Syndrome & Related Disorders. 19(1):32-38, 2021 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mendes CG; Barbalho SM; Tofano RJ; Lopes G; Quesada KR; Detregiachi CRP; Guiguer EL; Rubira CJ; Araujo AC
+Authors Full Name
+ Mendes, Claudemir Gregorio; Barbalho, Sandra Maria; Tofano, Ricardo Jose; Lopes, Gabriela; Quesada, Karina Rodrigues; Detregiachi, Claudia Rucco Penteado; Guiguer, Elen Landgraf; Rubira, Claudio Jose; Araujo, Adriano Cressoni.
+Institution
+ Mendes, Claudemir Gregorio. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia, Brazil.
+ Mendes, Claudemir Gregorio. Department of Biochemistry and Pharmacology, School of Medicine, University of Marilia (UNIMAR), Marilia, Brazil.
+ Barbalho, Sandra Maria. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia, Brazil.
+ Barbalho, Sandra Maria. Department of Biochemistry and Pharmacology, School of Medicine, University of Marilia (UNIMAR), Marilia, Brazil.
+ Barbalho, Sandra Maria. Department of Nutrition, School of Food and Technology of Marilia (FATEC), Marilia, Brazil.
+ Tofano, Ricardo Jose. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia, Brazil.
+ Tofano, Ricardo Jose. Department of Biochemistry and Pharmacology, School of Medicine, University of Marilia (UNIMAR), Marilia, Brazil.
+ Lopes, Gabriela. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia, Brazil.
+ Quesada, Karina Rodrigues. Department of Biochemistry and Pharmacology, School of Medicine, University of Marilia (UNIMAR), Marilia, Brazil.
+ Detregiachi, Claudia Rucco Penteado. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia, Brazil.
+ Guiguer, Elen Landgraf. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia, Brazil.
+ Guiguer, Elen Landgraf. Department of Biochemistry and Pharmacology, School of Medicine, University of Marilia (UNIMAR), Marilia, Brazil.
+ Guiguer, Elen Landgraf. Department of Nutrition, School of Food and Technology of Marilia (FATEC), Marilia, Brazil.
+ Rubira, Claudio Jose. Department of Biochemistry and Pharmacology, School of Medicine, University of Marilia (UNIMAR), Marilia, Brazil.
+ Araujo, Adriano Cressoni. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia, Brazil.
+ Araujo, Adriano Cressoni. Department of Biochemistry and Pharmacology, School of Medicine, University of Marilia (UNIMAR), Marilia, Brazil.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ Cross-Sectional Studies
+ Female
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/pa [Pathology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ *Neck/pa [Pathology]
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/pa [Pathology]
+ Obesity/pp [Physiopathology]
+ Predictive Value of Tests
+ Reproducibility of Results
+ *Waist Circumference
+Keyword Heading
+ cardiovascular diseases
+ metabolic syndrome
+ neck circumference
+ obesity
+ waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Metabolic syndrome (MS) comprises a cluster of risk factors for the development of cardiovascular diseases, which are among the leading causes of morbidity and mortality worldwide. Many studies have shown that neck circumference (NC) has validity in the measure of MS since it correlates positively with the traditional components. For these reasons, this study aimed at comparing waist circumference (WC) and NC for identifying MS parameters in patients treated at a cardiology unit. Methods: This study included 309 patients assisted in a Cardiology Unit. Biochemical and anthropometric parameters were evaluated. Correlations between neck and WC with anthropometric, biochemical, and atherogenic indices were evaluated. The diagnostic ability of neck and WC was assessed by using the receiver operating characteristics curve. Results: The patients had a mean age of 57.2 years, and 56% were men. The diagnosis of MS was present in 48% of men and 39% of women. Neck and WC showed a positive correlation with each other, and both showed positive correlations with the criteria for MS. Moreover, NC showed a positive correlation with body mass index (BMI), insulin, homeostatic model assessment (HOMA)-beta, and C-reactive protein. WC showed a positive correlation with BMI, HOMA of insulin resistance (HOMA-IR), and Castelli Index I. Both neck and WC showed the ability to identify the presence of the MS. Conclusion: Both neck and WC showed a significant correlation with several of the metabolic parameters, including some used as criteria for the diagnosis of MS. In addition, both measures demonstrated a good ability to predict MS, making these measures promising for screening patients with this syndrome.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Insulin). 0 (Lipids). 0 (hemoglobin A1c protein, human). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Comparative Study. Journal Article. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1089%2fmet.2020.0083
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mendes&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Is+Neck+Circumference+As+Reliable+As+Waist+Circumference+for+Determining+Metabolic+Syndrome%3F.&volume=19&issue=1&spage=32&epage=38&date=2021&doi=10.1089%2Fmet.2020.0083&pmid=32990516&sid=OVID:medline
+
+<1047>
+Unique Identifier
+ 32940695
+Title
+ Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.
+Source
+ Nutrition Reviews. 79(1):98-113, 2021 01 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dorling JL; van Vliet S; Huffman KM; Kraus WE; Bhapkar M; Pieper CF; Stewart T; Das SK; Racette SB; Roberts SB; Ravussin E; Redman LM; Martin CK
+Corporate Author
+ CALERIE Study Group
+Authors Full Name
+ Dorling, James L; van Vliet, Stephan; Huffman, Kim M; Kraus, William E; Bhapkar, Manjushri; Pieper, Carl F; Stewart, Tiffany; Das, Sai Krupa; Racette, Susan B; Roberts, Susan B; Ravussin, Eric; Redman, Leanne M; Martin, Corby K.
+Institution
+ Dorling, James L. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
+ van Vliet, Stephan. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
+ Huffman, Kim M. Duke University School of Medicine, Durham, North Carolina, USA.
+ Kraus, William E. Duke University School of Medicine, Durham, North Carolina, USA.
+ Bhapkar, Manjushri. Duke University School of Medicine, Durham, North Carolina, USA.
+ Pieper, Carl F. Duke University School of Medicine, Durham, North Carolina, USA.
+ Stewart, Tiffany. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
+ Das, Sai Krupa. US Department of Agriculture, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
+ Racette, Susan B. Washington University School of Medicine, St. Louis, Missouri, USA.
+ Roberts, Susan B. US Department of Agriculture, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
+ Ravussin, Eric. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
+ Redman, Leanne M. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
+ Martin, Corby K. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
+MeSH Subject Headings
+ Adult
+ *Aging
+ *Biomarkers/an [Analysis]
+ *Caloric Restriction
+ *Energy Intake
+ Energy Metabolism
+ Female
+ Humans
+ Inflammation
+ Longevity
+ Male
+ Middle Aged
+ Nutritional Status
+ Obesity
+ Oxidative Stress
+ Young Adult
+Keyword Heading
+ aging
+ longevity
+ metabolism
+ quality of life
+ randomized controlled trial
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trials are part of a research program aiming to test the effects of CR on aging and longevity biomarkers in humans. Building on CALERIE phase 1, CALERIE phase 2 (CALERIE 2) was the largest study to date to assess sustained CR in healthy humans without obesity. In a 24-month randomized controlled trial comprising 218 participants at baseline, CALERIE 2 showed that moderate CR, 11.9% on average, induced improvements in aging-related biomarkers without adversely affecting psychological or behavioral outcomes. The objectives of this report are to summarize and review the highlights of CALERIE 2 and report previously unpublished results on eating disorder symptoms and cognitive function. This article specifically summarizes the physiological, psychological, aging, behavioral, and safety results of the trial. Also provided are research directions beyond CALERIE 2 that highlight important opportunities to investigate the role of CR in aging, longevity, and health span in humans. Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial, Phase II. Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1093%2fnutrit%2fnuaa085
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dorling&issn=0029-6643&title=Nutrition+Reviews&atitle=Effects+of+caloric+restriction+on+human+physiological%2C+psychological%2C+and+behavioral+outcomes%3A+highlights+from+CALERIE+phase+2.&volume=79&issue=1&spage=98&epage=113&date=2021&doi=10.1093%2Fnutrit%2Fnuaa085&pmid=32940695&sid=OVID:medline
+
+<1048>
+Unique Identifier
+ 32935481
+Title
+ Contribution of gestational diabetes mellitus heterogeneity and prepregnancy body mass index to large-for-gestational-age infants-A retrospective case-control study.
+Source
+ Journal Of Diabetes. 13(4):307-317, 2021 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang N; Song L; Sun B; Peng Y; Fei S; Cui J; Mi Y; Cui W
+Author NameID
+ Cui, Wei; ORCID: https://orcid.org/0000-0002-5666-0919
+Authors Full Name
+ Wang, Ning; Song, Lin; Sun, Bo; Peng, Yanqi; Fei, Sijia; Cui, Jiaqi; Mi, Yang; Cui, Wei.
+Institution
+ Wang, Ning. Department of Endocrinology and Second Department of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
+ Song, Lin. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
+ Sun, Bo. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
+ Peng, Yanqi. Department of Endocrinology and Second Department of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
+ Fei, Sijia. Department of Endocrinology and Second Department of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
+ Cui, Jiaqi. Department of Endocrinology and Second Department of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
+ Mi, Yang. The Second Department of Obstetrics, Northwest Women and Children's Hospital, Xi'an, China.
+ Cui, Wei. Department of Endocrinology and Second Department of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Birth Weight
+ *Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ China
+ *Diabetes, Gestational/bl [Blood]
+ Diabetes, Gestational/di [Diagnosis]
+ Female
+ Fetal Macrosomia/di [Diagnosis]
+ *Fetal Macrosomia/et [Etiology]
+ Humans
+ Infant, Newborn
+ *Maternal Health
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Pregnancy
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ gestational diabetes mellitus
+ heterogeneity
+ obesity
+ retrospective study
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To study the associations between heterogeneity of gestational diabetes mellitus (GDM) subtype/prepregnancy body mass index (pre-BMI) and large-for-gestational-age (LGA) infants of Chinese women.
+
+ METHODS: We performed a retrospective case-control study of 299 women with GDM and 204 women with normal glucose tolerance (NGT), using oral glucose tolerance test-based indices performed at 24-25 weeks of gestation. Women with GDM were classified into the following three physiologic subtypes: GDM with a predominant insulin-secretion defect (GDM-dysfunction), GDM with a predominant insulin-sensitivity defect (GDM-resistance), or GDM with both defects (GDM-mixed). We then used a binary logistic regression model to evaluate the potential associations of GDM subtypes and pre-BMI with newborn macrosomia or LGA.
+
+ RESULTS: Women with GDM-resistance had a higher pre-BMI (P < 0.001), whereas women in the GDM-dysfunction and GDM-mixed groups had pre-BMIs comparable to the NGT group. In the logistic regression model, women in the GDM-mixed group exhibited an increased risk of bearing newborns with macrosomia and LGA, and women in the GDM-dysfunction group tended to have newborns with LGA after adjusting for pre-BMI and other potential confounders. Women who were overweight or obese prepregnancy manifested an increased risk of having newborns with macrosomia and LGA relative to normal-weight women, regardless of whether values were unadjusted or adjusted for all potential confounders. There was no significant interaction between GDM subtype and pre-BMI for any of the studied outcomes.
+
+ CONCLUSIONS: Heterogeneity of GDM (GDM-dysfunction and GDM-mixed) and prepregnancy overweight/obesity were independently associated with LGA in Chinese women. There was no significant interaction between GDM subtypes and pre-BMI for LGA. Copyright © 2020 Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.
+Other Abstract
+ Publisher
+ : , (gestational diabetes mellitus, GDM) (pre-pregnancy body mass index, pre-BMI) (large-for-gestational-age, LGA) : , 299 GDM 204 (normal glucose tolerance, NGT) GDM 24-25 , GDM : (GDM-dysfunction, GDM-dys), (GDM-resistance, GDM-res), (GDM-mixed) logistic GDM /pre-BMI LGA : GDM-res pre-BMI (P < 0.001), GDM-dys GDM-mixed NGT pre-BMI logistic , GDM-mixed LGA , pre-BMI , GDM-dys LGA , , / LGA , GDM pre-BMI : GDM , , GDM-dys/GDM-mixed / LGA GDM pre-BMI LGA .
+ Language: Chinese
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2f1753-0407.13113
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1753-0407&title=Journal+Of+Diabetes&atitle=Contribution+of+gestational+diabetes+mellitus+heterogeneity+and+prepregnancy+body+mass+index+to+large-for-gestational-age+infants-A+retrospective+case-control+study.&volume=13&issue=4&spage=307&epage=317&date=2021&doi=10.1111%2F1753-0407.13113&pmid=32935481&sid=OVID:medline
+
+<1049>
+Unique Identifier
+ 32860944
+Title
+ Reply to "Meta-analysis of astaxanthin supplementation on obesity, blood pressure, CRP, glycemic biomarkers, and lipid profile: Reanalysis is needed".
+Source
+ Pharmacological Research. 163:105167, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xia W; Tang N; Kord-Varkaneh H; Low TY; Tan SC; Wu X; Zhu Y
+Authors Full Name
+ Xia, Wei; Tang, Nie; Kord-Varkaneh, Hamed; Low, Teck Yew; Tan, Shing Cheng; Wu, Xin; Zhu, Ying.
+Institution
+ Xia, Wei. Department of Endocrinology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China.
+ Tang, Nie. Department of Endocrinology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China.
+ Kord-Varkaneh, Hamed. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Low, Teck Yew. UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
+ Tan, Shing Cheng. UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
+ Wu, Xin. Heart Failure Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China. Electronic address: wuwucat5455@sina.com.
+ Zhu, Ying. Department of Endocrinology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China. Electronic address: zhuying_2004@163.com.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Biomarkers
+ Blood Pressure
+ Dietary Supplements
+ Humans
+ *Lipids
+ Obesity/dt [Drug Therapy]
+ *Obesity
+ Randomized Controlled Trials as Topic
+ Xanthophylls
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 0 (Xanthophylls). 8XPW32PR7I (astaxanthine).
+Publication Type
+ Letter. Research Support, Non-U.S. Gov't. Comment.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.phrs.2020.105167
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xia&issn=1043-6618&title=Pharmacological+Research&atitle=Reply+to+%22Meta-analysis+of+astaxanthin+supplementation+on+obesity%2C+blood+pressure%2C+CRP%2C+glycemic+biomarkers%2C+and+lipid+profile%3A+Reanalysis+is+needed%22.&volume=163&issue=&spage=105167&epage=&date=2021&doi=10.1016%2Fj.phrs.2020.105167&pmid=32860944&sid=OVID:medline
+
+<1050>
+Unique Identifier
+ 32858120
+Title
+ Meta-analysis of astaxanthin supplementation on obesity, blood pressure, CRP, glycemic biomarkers, and lipid profile: Reanalysis is needed.
+Source
+ Pharmacological Research. 163:105171, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hajhashemy Z; Saneei P
+Authors Full Name
+ Hajhashemy, Zahra; Saneei, Parvane.
+Institution
+ Hajhashemy, Zahra. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Saneei, Parvane. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: saneei@nutr.mui.ac.ir.
+Comments
+ Comment on (CON)
+ Comment in (CIN)
+MeSH Subject Headings
+ Biomarkers
+ Blood Pressure
+ Dietary Supplements
+ Humans
+ *Lipids
+ Obesity/dt [Drug Therapy]
+ *Obesity
+ Randomized Controlled Trials as Topic
+ Xanthophylls
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 0 (Xanthophylls). 8XPW32PR7I (astaxanthine).
+Publication Type
+ Letter. Research Support, Non-U.S. Gov't. Comment.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.phrs.2020.105171
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hajhashemy&issn=1043-6618&title=Pharmacological+Research&atitle=Meta-analysis+of+astaxanthin+supplementation+on+obesity%2C+blood+pressure%2C+CRP%2C+glycemic+biomarkers%2C+and+lipid+profile%3A+Reanalysis+is+needed.&volume=163&issue=&spage=105171&epage=&date=2021&doi=10.1016%2Fj.phrs.2020.105171&pmid=32858120&sid=OVID:medline
+
+<1051>
+Unique Identifier
+ 32852705
+Title
+ Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease.
+Source
+ Journal of Endocrinological Investigation. 44(5):979-988, 2021 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Barchetta I; Ceccarelli V; Cimini FA; Barone E; Sentinelli F; Coluzzi M; Chiappetta C; Bertoccini L; Tramutola A; Labbadia G; Di Cristofano C; Silecchia G; Leonetti F; Cavallo MG
+Author NameID
+ Cavallo, Maria G; ORCID: http://orcid.org/0000-0001-6630-8049
+Authors Full Name
+ Barchetta, Ilaria; Ceccarelli, Valentina; Cimini, Flavia A; Barone, Eugenio; Sentinelli, Federica; Coluzzi, Mariagrazia; Chiappetta, Caterina; Bertoccini, Laura; Tramutola, Antonella; Labbadia, Giancarlo; Di Cristofano, Claudio; Silecchia, Gianfranco; Leonetti, Frida; Cavallo, Maria G.
+Institution
+ Barchetta, Ilaria. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
+ Ceccarelli, Valentina. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
+ Cimini, Flavia A. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
+ Barone, Eugenio. Department of Biochemical Sciences "A. Rossi-Fanelli", Sapienza University of Rome, Rome, Italy.
+ Sentinelli, Federica. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
+ Coluzzi, Mariagrazia. Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Rome, Italy.
+ Chiappetta, Caterina. Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Rome, Italy.
+ Bertoccini, Laura. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
+ Tramutola, Antonella. Department of Biochemical Sciences "A. Rossi-Fanelli", Sapienza University of Rome, Rome, Italy.
+ Labbadia, Giancarlo. Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
+ Di Cristofano, Claudio. Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Rome, Italy.
+ Silecchia, Gianfranco. Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Rome, Italy.
+ Leonetti, Frida. Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Rome, Italy.
+ Cavallo, Maria G. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. gisella.cavallo@uniroma1.it.
+MeSH Subject Headings
+ Bariatric Surgery/mt [Methods]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Biopsy/mt [Methods]
+ Cardiometabolic Risk Factors
+ Cost-Benefit Analysis
+ Dipeptidyl Peptidase 4/bl [Blood]
+ Dipeptidyl Peptidase 4/me [Metabolism]
+ *Dipeptidyl Peptidase 4
+ Disease Progression
+ Female
+ Humans
+ Italy/ep [Epidemiology]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ *Liver
+ Male
+ Middle Aged
+ Monitoring, Physiologic/mt [Methods]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Obesity/su [Surgery]
+ *Obesity
+ Patient Acuity
+ Risk Assessment/mt [Methods]
+Keyword Heading
+ DPP4
+ Fatty liver
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Dipeptidyl peptidase 4 (DPP4) levels are associated to metabolic and cardiovascular diseases in humans; initial evidence reported a relationship between DPP4 and chronic liver diseases. Aim of this study was to investigate hepatic and systemic DPP4 levels/activity in relation to NAFLD/NASH in individuals with and without metabolic disease.
+
+ METHODS: We recruited fifty-two obese individuals undergoing bariatric surgery and intra-operative liver biopsy at Sapienza University, Rome, Italy. The association between DPP4 levels/activity and NAFLD was also evaluated in 126 non-obese individuals recruited in the same setting.
+
+ RESULTS: NAFLD patients had significantly higher circulating DPP4 activity than no-NAFLD in both the obese and non-obese cohorts; plasma DPP4 activity and levels linearly correlated with steatosis grade and inflammation at the liver biopsy. Hepatic DPP4 mRNA was not associated to either its circulating levels/activity or NAFLD. In the multivariate logistic regression analysis on all the study participants (n = 178), higher circulating DPP4 activity was associated with NAFLD independently of potential confounders with OR (95% CI): 3.5 (1.2-10.21), p = 0.022.
+
+ CONCLUSIONS: This study demonstrates the coexistence of increased plasma DPP4 levels and activity in NAFLD. Circulating DPP4 measurement may represent a novel cost-effective strategy for NAFLD/NASH risk stratification and a potential tool for monitoring disease's progression in established NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4-14-5 (Dipeptidyl Peptidase 4).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs40618-020-01392-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Barchetta&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Circulating+dipeptidyl+peptidase-4+is+independently+associated+with+the+presence+and+severity+of+NAFLD%2FNASH+in+individuals+with+and+without+obesity+and+metabolic+disease.&volume=44&issue=5&spage=979&epage=988&date=2021&doi=10.1007%2Fs40618-020-01392-5&pmid=32852705&sid=OVID:medline
+
+<1052>
+Unique Identifier
+ 32845813
+Title
+ The Role of Visceral Adiposity Index as Predictor of Metabolic Syndrome in Obese and Nonobese Women with Polycystic Ovary Syndrome.
+Source
+ Metabolic Syndrome & Related Disorders. 19(1):18-25, 2021 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Medeiros SF; de Medeiros MAS; Barbosa BB; Yamamoto MMW
+Authors Full Name
+ de Medeiros, Sebastiao Freitas; de Medeiros, Matheus Antonio Souto; Barbosa, Bruna Barcelo; Yamamoto, Marcia Marly Winck.
+Institution
+ de Medeiros, Sebastiao Freitas. Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiaba, Brazil.
+ de Medeiros, Sebastiao Freitas. Department of Gynecology and Obstetrics, Tropical Institute of Reproductive Medicine, Cuiaba, Brazil.
+ de Medeiros, Matheus Antonio Souto. Department of Gynecology and Obstetrics, Tropical Institute of Reproductive Medicine, Cuiaba, Brazil.
+ Barbosa, Bruna Barcelo. Department of Gynecology and Obstetrics, Tropical Institute of Reproductive Medicine, Cuiaba, Brazil.
+ Yamamoto, Marcia Marly Winck. Department of Gynecology and Obstetrics, Tropical Institute of Reproductive Medicine, Cuiaba, Brazil.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Brazil/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ *Intra-Abdominal Fat/pp [Physiopathology]
+ Lipids/bl [Blood]
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ *Polycystic Ovary Syndrome/ep [Epidemiology]
+ Polycystic Ovary Syndrome/pp [Physiopathology]
+ Prevalence
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ Young Adult
+Keyword Heading
+ anthropometry
+ hyperandrogenism
+ insulin resistance
+ metabolic syndrome
+ obesity
+ polycystic ovary syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: To evaluate anthropometric-metabolic biomarkers as predictors of metabolic syndrome (MS) in women with polycystic ovary syndrome (PCOS) with and without obesity. Methods: This was an observational cross-sectional study. Patients were classified as nonobese-PCOS (body mass index, BMI <30 kg/m2, n = 385), and obese-PCOS (BMI >=30 kg/m2, n = 261). The anthropometric parameters waist circumference, waist/hip ratio, lean body mass, fat body mass, visceral adiposity index (VAI), lipid accumulating product, and biomarkers of glucose and lipid metabolisms were compared between groups. Binominal logistic regression analyses were performed to identify predictors of MS. Results: Obesity was diagnosed in 40% of all PCOS women (P < 0.001). Blood pressure and anthropometric abnormalities were significantly more frequent in obese-PCOS women (P < 0.001, for all comparisons). Glucose metabolism markers were higher in obese-PCOS compared with nonobese-PCOS (P < 0.001, for all comparisons). High-density lipoprotein cholesterol was lower in obese group than in nonobese group (1.26 mM vs. 1.08 mM, P < 0.001). MS was found in 23 of 385 (6%) nonobese-PCOS and in 116 of 261 (44.4%) obese-PCOS (P < 0.001). VAI was the best predictor of MS in both nonobese-PCOS (OR = 4.1, 95% CI 1.5-11.1) and obese-PCOS (OR = 12.9, 95% CI 5.7-29.0). Conclusions: MS is more prevalent in PCOS women with obesity. VAI was the strongest predictor of MS in both obese and nonobese PCOS women, and can be applied in clinical practice for early detection of risk for MS and precocious intervention in women with PCOS, particularly in obese women.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Lipids).
+Publication Type
+ Comparative Study. Journal Article. Multicenter Study. Observational Study.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1089%2fmet.2020.0045
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Medeiros&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=The+Role+of+Visceral+Adiposity+Index+as+Predictor+of+Metabolic+Syndrome+in+Obese+and+Nonobese+Women+with+Polycystic+Ovary+Syndrome.&volume=19&issue=1&spage=18&epage=25&date=2021&doi=10.1089%2Fmet.2020.0045&pmid=32845813&sid=OVID:medline
+
+<1053>
+Unique Identifier
+ 32835719
+Title
+ Endometrial biomarkers in premenopausal women with obesity: an at-risk cohort.
+Source
+ American Journal of Obstetrics & Gynecology. 224(3):278.e1-278.e14, 2021 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dottino JA; Zhang Q; Loose DS; Fellman B; Melendez BD; Borthwick MS; McKenzie LJ; Yuan Y; Yang RK; Broaddus RR; Lu KH; Soliman PT; Yates MS
+Authors Full Name
+ Dottino, Joseph A; Zhang, Qian; Loose, David S; Fellman, Bryan; Melendez, Brenda D; Borthwick, Mikayla S; McKenzie, Laurie J; Yuan, Ying; Yang, Richard K; Broaddus, Russell R; Lu, Karen H; Soliman, Pamela T; Yates, Melinda S.
+Institution
+ Dottino, Joseph A. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Zhang, Qian. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Loose, David S. Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX.
+ Fellman, Bryan. Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Melendez, Brenda D. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Borthwick, Mikayla S. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
+ McKenzie, Laurie J. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Yuan, Ying. Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Yang, Richard K. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Broaddus, Russell R. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.
+ Lu, Karen H. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Soliman, Pamela T. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
+ Yates, Melinda S. Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: msyates@mdanderson.org.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Cohort Studies
+ Cross-Sectional Studies
+ Endometrial Neoplasms/ep [Epidemiology]
+ Endometrial Neoplasms/et [Etiology]
+ Endometrium/me [Metabolism]
+ Endometrium/pa [Pathology]
+ Estrogens/bi [Biosynthesis]
+ *Estrogens/bl [Blood]
+ Female
+ Humans
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Premenopause/bl [Blood]
+ Risk Factors
+Keyword Heading
+ Lynch syndrome
+ endometrial cancer
+ obesity
+ premenopausal
+ prevention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a well-known risk factor for endometrial cancer, but the mechanisms of obesity-related carcinogenesis are not well defined, particularly for premenopausal women. With the continuing obesity epidemic, increases in the incidence of endometrial cancer and a younger age of diagnosis are often attributed to a hyperestrogenic state created by hormone production in adipose tissue, but significant knowledge gaps remain. The balance of estrogen-responsive signals has not been defined in the endometrium of premenopausal women with obesity, where obesity may not create hyperestrogenism in the context of ovaries being the primary source of estrogen production. Obesity is associated with a state of low-grade, chronic inflammation that can promote tumorigenesis, and it is also known that hormonal changes alter the immune microenvironment of the endometrium. However, limited research has been conducted on endometrial immune-response changes in women who have an increased risk for cancer due to obesity.
+
+ OBJECTIVE: Endometrial estrogen-regulated biomarkers, previously shown to be dysregulated in endometrial cancer, were evaluated in a cohort of premenopausal women to determine if obesity is associated with differences in the biomarker expression levels, which might reflect an altered risk of developing cancer. The expression of a multiplexed panel of immune-related genes was also evaluated for expression differences related to obesity.
+
+ STUDY DESIGN: Premenopausal women with a body mass index of >=30 kg/m2 (n=97) or a body mass index of <=25 kg/m2 (n=33) were prospectively enrolled in this cross-sectional study, which included the assessment of serum metabolic markers and a timed endometrial biopsy for pathologic evaluation, hormone-regulated biomarker analysis, and immune response gene expression analysis. Medical and gynecologic histories were obtained. Endometrial gene expression markers were also compared across the body mass index groups in a previous cohort of premenopausal women with an inherited cancer risk (Lynch syndrome).
+
+ RESULTS: In addition to known systemic metabolic differences, histologically normal endometria from women with obesity showed a decrease in gene expression of progesterone receptor (P=.0027) and the estrogen-induced genes retinaldehyde dehydrogenase 2 (P=.008), insulin-like growth factor 1 (P=.016), and survivin (P=.042) when compared with women without obesity. The endometrial biomarkers insulin-like growth factor 1, survivin, and progesterone receptor remained statistically significant in multivariate linear regression models. In contrast, women with obesity and Lynch syndrome had an increased expression of insulin-like growth factor 1 (P=.017). There were no differences in endometrial proliferation, and limited endometrial immune differences were observed.
+
+ CONCLUSION: When comparing premenopausal women with and without obesity in the absence of endometrial pathology or an inherited cancer risk, the expression of the endometrial biomarkers does not reflect a local hyperestrogenic environment, but it instead reflects a decreased cancer risk profile that may be indicative of a compensated state. In describing premenopausal endometrial cancer risk, it may be insufficient to attribute a high-risk state to obesity alone; further studies are warranted to evaluate individualized biomarker profiles for differences in the hormone-responsive signals or immune response. In patients with Lynch syndrome, the endometrial biomarker profile suggests that obesity further increases the risk of developing cancer. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Estrogens).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.ajog.2020.08.053
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dottino&issn=0002-9378&title=American+Journal+of+Obstetrics+%26+Gynecology&atitle=Endometrial+biomarkers+in+premenopausal+women+with+obesity%3A+an+at-risk+cohort.&volume=224&issue=3&spage=278.e1&epage=278.e14&date=2021&doi=10.1016%2Fj.ajog.2020.08.053&pmid=32835719&sid=OVID:medline
+
+<1054>
+Unique Identifier
+ 32816247
+Title
+ Serum glypican4 and glycosylphosphatidylinositol-specific phospholipase D levels are associated with adipose tissue insulin resistance in obese subjects with different glucose metabolism status.
+Source
+ Journal of Endocrinological Investigation. 44(4):781-790, 2021 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang K; Zhu H; Wang L; Yang H; Pan H; Gong F
+Author NameID
+ Pan, H; ORCID: http://orcid.org/0000-0003-2413-0646
+Authors Full Name
+ Zhang, K; Zhu, H; Wang, L; Yang, H; Pan, H; Gong, F.
+Institution
+ Zhang, K. Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
+ Zhang, K. Department of Endocrinology, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei, People's Republic of China.
+ Zhu, H. Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
+ Wang, L. Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
+ Yang, H. Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
+ Pan, H. Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China. panhui20111111@163.com.
+ Gong, F. Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China. fygong@sina.com.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Blood Glucose/me [Metabolism]
+ *Blood Glucose
+ China/ep [Epidemiology]
+ Cohort Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Female
+ Glucose Intolerance/bl [Blood]
+ Glucose Intolerance/di [Diagnosis]
+ Glucose Tolerance Test/mt [Methods]
+ *Glypicans/bl [Blood]
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ *Obesity
+ *Phospholipase D/bl [Blood]
+Keyword Heading
+ Adiponectin (ADP)
+ Adipose tissue insulin resistance (adipo-IR)
+ Glycosylphosphatidylinositol-specific phospholipase D (GPLD1)
+ Glypican4 (GPC4)
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Glypican4 (GPC4) is a novel adipokine associated with obesity and insulin resistance. GPC4 was cleaved by the glycosylphosphatidylinositol-specific phospholipase D (GPLD1) in an anchored site of the glycosylphosphatidylinositol, and then was released into the extracellular environment. Herein, we investigated the changes of serum GPC4 and GPLD1 levels in obese subjects with different glucose metabolism status and their relationship with adipose tissue insulin resistance index (Adipo-IR) in Chinese north populations.
+
+ METHODS: A total of 221 obese subjects and 37 normal controls (NC) were recruited in this study. Obese subjects were divided into normal insulin (NI) group, hyperinsulinemia (HI) group, impaired glucose tolerance (IGT) group, and type 2 diabetes mellitus (DM) group. Serum GPC4, GPLD1, and adiponectin were determined by commercially available ELISA kits.
+
+ RESULTS: Serum GPC4 levels in the HI, IGT, and DM groups were significantly higher than those in the NC and NI groups (2.27 +/- 0.58 ng/mL, 2.21 +/- 0.60 ng/mL, 2.49 +/- 0.67 ng/mL vs. 1.70 +/- 0.33 ng/mL, 1.93 +/- 0.34 ng/mL, P < 0.05). GPC4 was positively correlated with GPLD1, which was the most important influencing factor of GPC4. Adipo-IR was independently and positively associated with serum GPC4 and GPLD1. For GPC4, after adjustment for confounders, the risk of adipose tissue insulin resistance in subjects with the highest tertile was 2.974-fold that of those with the lowest tertile (OR = 2.974, P = 0.013). For GPLD1, before adjustment for lipids, the increased probability still existed (Model 2, OR = 3.568, P = 0.003).
+
+ CONCLUSION: GPC4 is an adipokine associated with adipose tissue insulin resistance, and its activity may be regulated by GPLD1. GPC4 may be a marker for adipose tissue insulin resistance in Chinese north obese populations.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glypicans). 0 (Insulin). EC 3-1-4-4 (Phospholipase D). EC 3-1-4-50 (glycoprotein phospholipase D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs40618-020-01372-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Serum+glypican4+and+glycosylphosphatidylinositol-specific+phospholipase+D+levels+are+associated+with+adipose+tissue+insulin+resistance+in+obese+subjects+with+different+glucose+metabolism+status.&volume=44&issue=4&spage=781&epage=790&date=2021&doi=10.1007%2Fs40618-020-01372-9&pmid=32816247&sid=OVID:medline
+
+<1055>
+Unique Identifier
+ 32791310
+Title
+ Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
+Source
+ Diabetes & Metabolism. 47(2):101183, 2021 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leon-Mimila P; Villamil-Ramirez H; Li XS; Shih DM; Hui ST; Ocampo-Medina E; Lopez-Contreras B; Moran-Ramos S; Olivares-Arevalo M; Grandini-Rosales P; Macias-Kauffer L; Gonzalez-Gonzalez I; Hernandez-Pando R; Gomez-Perez F; Campos-Perez F; Aguilar-Salinas C; Larrieta-Carrasco E; Villarreal-Molina T; Wang Z; Lusis AJ; Hazen SL; Huertas-Vazquez A; Canizales-Quinteros S
+Authors Full Name
+ Leon-Mimila, P; Villamil-Ramirez, H; Li, X S; Shih, D M; Hui, S T; Ocampo-Medina, E; Lopez-Contreras, B; Moran-Ramos, S; Olivares-Arevalo, M; Grandini-Rosales, P; Macias-Kauffer, L; Gonzalez-Gonzalez, I; Hernandez-Pando, R; Gomez-Perez, F; Campos-Perez, F; Aguilar-Salinas, C; Larrieta-Carrasco, E; Villarreal-Molina, T; Wang, Z; Lusis, A J; Hazen, S L; Huertas-Vazquez, A; Canizales-Quinteros, S.
+Institution
+ Leon-Mimila, P. Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, USA; Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico.
+ Villamil-Ramirez, H. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico.
+ Li, X S. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
+ Shih, D M. Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, USA.
+ Hui, S T. Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, USA.
+ Ocampo-Medina, E. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico.
+ Lopez-Contreras, B. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico.
+ Moran-Ramos, S. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico; Catedras, CONACyT, Mexico City, Mexico.
+ Olivares-Arevalo, M. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico.
+ Grandini-Rosales, P. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico.
+ Macias-Kauffer, L. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico.
+ Gonzalez-Gonzalez, I. Clinica Integral de Cirugia para la Obesidad y Enfermedades Metabolicas, Hospital General Dr. Ruben Lenero, Mexico City, Mexico.
+ Hernandez-Pando, R. Departamento de Patologia Experimental, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Mexico City, Mexico.
+ Gomez-Perez, F. Departamento de Endocrinologia, INCMNSZ, Mexico City, Mexico.
+ Campos-Perez, F. Clinica Integral de Cirugia para la Obesidad y Enfermedades Metabolicas, Hospital General Dr. Ruben Lenero, Mexico City, Mexico.
+ Aguilar-Salinas, C. Departamento de Endocrinologia, INCMNSZ, Mexico City, Mexico; Unidad de Investigacion en Enfermedades Metabolicas, INCMNSZ, Mexico City, Mexico; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Nuevo Leon 64710, Mexico.
+ Larrieta-Carrasco, E. Departamento de Gastroenterologia, INCMNSZ, Mexico City, Mexico.
+ Villarreal-Molina, T. Laboratorio de Genomica de Enfermedades Cardiovasculares, INMEGEN, Mexico City, Mexico.
+ Wang, Z. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
+ Lusis, A J. Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, USA.
+ Hazen, S L. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
+ Huertas-Vazquez, A. Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, USA. Electronic address: adrianahuertasv@gmail.com.
+ Canizales-Quinteros, S. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM/INMEGEN, Mexico City, Mexico. Electronic address: cani@unam.mx.
+MeSH Subject Headings
+ Adult
+ Betaine/bl [Blood]
+ Bile Acids and Salts/bl [Blood]
+ Biomarkers/bl [Blood]
+ Biopsy
+ Choline/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2
+ Female
+ Humans
+ Insulin Resistance
+ Liver/pa [Pathology]
+ Male
+ *Methylamines/bl [Blood]
+ Mexican Americans
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+Keyword Heading
+ Non-alcoholic fatty liver disease
+ TMAO
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance. However, the relationships among these metabolites, insulin resistance and NAFLD have not been thoroughly investigated. Moreover, it has recently been suggested that TMAO could play a role in NAFLD by altering bile acid metabolism. We examined the association between circulating TMAO, choline and betaine levels and NAFLD in obese subjects.
+
+ METHODS: Serum TMAO, choline, betaine and bile acid levels were measured in 357 Mexican obese patients with different grades of NAFLD as determined by liver histology. Associations of NAFLD with TMAO, choline and betaine levels were tested. Moreover, association of TMAO levels with non-alcoholic steatohepatitis (NASH) was tested separately in patients with and without T2D.
+
+ RESULTS: TMAO and choline levels were significantly associated with NAFLD histologic features and NASH risk. While increased serum TMAO levels were significantly associated with NASH in patients with T2D, in non-T2D subjects this association lost significance after adjusting for sex, BMI and HOMA2-IR. Moreover, circulating secondary bile acids were associated both with increased TMAO levels and NASH.
+
+ CONCLUSIONS: In obese patients, circulating TMAO levels were associated with NASH mainly in the presence of T2D. Functional studies are required to evaluate the role of insulin resistance and T2D in this association, both highly prevalent in NASH patients. Copyright © 2020 Elsevier Masson SAS. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers). 0 (Methylamines). 3SCV180C9W (Betaine). FLD0K1SJ1A (trimethyloxamine). N91BDP6H0X (Choline).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1016%2fj.diabet.2020.07.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leon-Mimila&issn=1262-3636&title=Diabetes+%26+Metabolism&atitle=Trimethylamine+N-oxide+levels+are+associated+with+NASH+in+obese+subjects+with+type+2+diabetes.&volume=47&issue=2&spage=101183&epage=&date=2021&doi=10.1016%2Fj.diabet.2020.07.010&pmid=32791310&sid=OVID:medline
+
+<1056>
+Unique Identifier
+ 32767532
+Title
+ Confounded by obesity and modulated by urinary uric acid excretion, sleep-disordered breathing indirectly relates to hyperuricaemia in males: A structural equation model.
+Source
+ Journal of Sleep Research. 30(3):e13108, 2021 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lai CH; Huang RJ; Wong JK; Chang SW; Chung AH; Chi YC; Yu YC; Lee SD; Ting H
+Author NameID
+ Ting, Hua; ORCID: https://orcid.org/0000-0003-3296-2776
+Authors Full Name
+ Lai, Ching-Hsiang; Huang, Ren-Jing; Wong, James Kok-Suh; Chang, Shen-Wen; Chung, Ai-Hui; Chi, Yung-Chun; Yu, Yi-Chen; Lee, Shin-Da; Ting, Hua.
+Institution
+ Lai, Ching-Hsiang. Department of Medical Informatics, Chung Shan Medical University, Taichung, Taiwan.
+ Huang, Ren-Jing. Department of Medical Image and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan.
+ Wong, James Kok-Suh. Department of Cardiology, Asia University Hospital, Taichung, Taiwan.
+ Chang, Shen-Wen. Sleep Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan.
+ Chung, Ai-Hui. Sleep Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan.
+ Chi, Yung-Chun. Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan.
+ Yu, Yi-Chen. Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan.
+ Lee, Shin-Da. Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
+ Lee, Shin-Da. Department of Occupational Therapy, Asia University, Taichung, Taiwan.
+ Lee, Shin-Da. School of Rehabilitation Science, Affiliated Seventh People Hospital, Shanghai University of TCM, Shanghai, China.
+ Ting, Hua. Sleep Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan.
+ Ting, Hua. Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan.
+ Ting, Hua. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Humans
+ Hyperuricemia/co [Complications]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Polysomnography/mt [Methods]
+ *Sleep Apnea Syndromes/pp [Physiopathology]
+ *Uric Acid/bl [Blood]
+Keyword Heading
+ hepatic dysfunction
+ metabolic syndrome
+ obstructive sleep apnea
+ renal dysfunction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Sleep-disordered breathing (SDB) causes hypoxic stress and can trigger uric acid (UA) overproduction. We comprehensively investigated whether SDB, interacting with components of metabolic syndrome, hepatic and renal dysfunctions, low physical fitness, sedentary lifestyle, disrupted sleep, and chronic systemic inflammation (CSI), is directly associated with hyperuricaemia. In 528 community-based males (mean [SD] age 46.2 [7.4] years), we cross-sectionally analysed measures of anthropometry; self-reported lifestyle habits; overnight sleep polysomnography data; cardiopulmonary exercise tests; and biomarkers of cardiometabolic, hepatic, and renal functions; and CSI, using structural equation modelling. Objective disrupted sleep, C-reactive protein, low physical fitness, and sedentary lifestyle were not related to UA levels in univariate analysis and were excluded. The latent variables (with corresponding manifest variables) obesity (body mass index, waist-hip ratio), hypertension (post-sleep systolic, diastolic blood pressure), dyslipidaemia (total cholesterol, triglyceride/high-density lipoprotein cholesterol), hepatic dysfunction (alanine aminotransferase, aspartate transaminase), and renal dysfunction (blood urea nitrogen, serum creatinine) were positively; and hyperglycaemia (fasting glucose, glycated haemoglobin) was negatively associated with hyperuricaemia (serum UA), except for SDB (Apnea-Hypopnea Index, percentage of oxygen saturation <90% period against total sleep time, oxygen desaturation index) in the one-stage influence model. In the two-stage model, SDB, closely interacting with obesity, was positively indirectly associated with hyperuricaemia through directly linked renal dysfunction and obesity-linked hypertension, inverse hyperglycaemia, dyslipidaemia, and hepatic dysfunction. In conclusion, structural equation modelling reveals that SDB closely interacts with obesity and is positively but indirectly related to hyperuricaemia in males. This suggests that urinary UA excretion modulates and obesity confounds the SDB-hyperuricaemia relationship. Copyright © 2020 European Sleep Research Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fjsr.13108
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lai&issn=0962-1105&title=Journal+of+Sleep+Research&atitle=Confounded+by+obesity+and+modulated+by+urinary+uric+acid+excretion%2C+sleep-disordered+breathing+indirectly+relates+to+hyperuricaemia+in+males%3A+A+structural+equation+model.&volume=30&issue=3&spage=e13108&epage=&date=2021&doi=10.1111%2Fjsr.13108&pmid=32767532&sid=OVID:medline
+
+<1057>
+Unique Identifier
+ 32762338
+Title
+ Untargeted Metabolomic Approach Shows No Differences in Subcutaneous Adipose Tissue of Diabetic and Non-Diabetic Subjects Undergoing Bariatric Surgery: An Exploratory Study.
+Source
+ Biological Research for Nursing. 23(1):109-118, 2021 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vizioli C; Jaime-Lara RB; Franks AT; Ortiz R; Joseph PV
+Author NameID
+ Vizioli, Carlotta; ORCID: https://orcid.org/0000-0002-5066-7386
+ Jaime-Lara, Rosario B; ORCID: https://orcid.org/0000-0002-5726-7529
+ Franks, Alexis T; ORCID: https://orcid.org/0000-0002-0550-334X
+ Ortiz, Rodrigo; ORCID: https://orcid.org/0000-0001-6751-3642
+ Joseph, Paule V; ORCID: https://orcid.org/0000-0002-1198-9622
+Authors Full Name
+ Vizioli, Carlotta; Jaime-Lara, Rosario B; Franks, Alexis T; Ortiz, Rodrigo; Joseph, Paule V.
+Institution
+ Vizioli, Carlotta. Sensory Science & Metabolism Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, 2511National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
+ Jaime-Lara, Rosario B. Sensory Science & Metabolism Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, 2511National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
+ Franks, Alexis T. Sensory Science & Metabolism Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, 2511National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
+ Ortiz, Rodrigo. Sensory Science & Metabolism Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, 2511National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
+ Joseph, Paule V. Sensory Science & Metabolism Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, 2511National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
+MeSH Subject Headings
+ Adult
+ *Bariatric Surgery
+ Biomarkers/me [Metabolism]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/su [Surgery]
+ Female
+ Humans
+ Inflammation
+ Insulin Resistance
+ Male
+ Metabolomics
+ Middle Aged
+ Obesity/me [Metabolism]
+ Obesity/su [Surgery]
+ Pilot Projects
+ *Subcutaneous Fat/me [Metabolism]
+ Subcutaneous Fat/su [Surgery]
+Keyword Heading
+ diabetes (T2DM)
+ insulin resistance (IR), bariatric surgery
+ obesity
+ subcutaneous adipose tissue (SAT)
+ untargeted metabolomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity plays a major role in the development of insulin resistance (IR) and diabetes (T2DM). Increased adipose tissue (AT) is particularly of interest because it activates a chronic inflammatory response in adipocytes and other tissues. AT plays key endocrine and metabolic functions, acting in the regulation of insulin sensitivity and energy homeostasis. Additionally, it can be easily collected during bariatric surgery. The purpose of this pilot study was to explore the potential differences in AT metabolism, through comparing the untargeted metabolomic profiles of diabetic and non-diabetic obese patients undergoing bariatric surgery.
+
+ METHODS: For this exploratory study, samples were collected from 17 subjects. Subcutaneous AT (SAT) samples from obese-diabetic (n = 8) and Obese-non-Diabetic (n = 9) subjects were obtained from the Human Metabolic Tissue Bank. Untargeted metabolomic profiling was performed by Metabolon R Inc. Statistical analysis was performed using the MetaboAnalyst 4.0 platform.
+
+ RESULTS: Among the 421 metabolites identified and analyzed there were no significant differences between the Obese-Diabetics and the Obese-non-Diabetics. Small changes were observed by fold change analysis mainly in lipid (n = 12; e.g. NEFAs) and amino acid (n = 8; e.g. BCAAs) metabolic pathways. Dysregulation of these metabolites has been associated with IR and other T2DM-related pathophysiological processes.
+
+ CONCLUSION: Obesity may influence SAT metabolism masking T2DM-dependent dysregulation. Better understanding the metabolic differences within SAT in diabetic populations may help identify potential biomarkers for diagnosis and monitoring of T2DM in patients undergoing bariatric surgery.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1177%2f1099800420942900
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vizioli&issn=1099-8004&title=Biological+Research+for+Nursing&atitle=Untargeted+Metabolomic+Approach+Shows+No+Differences+in+Subcutaneous+Adipose+Tissue+of+Diabetic+and+Non-Diabetic+Subjects+Undergoing+Bariatric+Surgery%3A+An+Exploratory+Study.&volume=23&issue=1&spage=109&epage=118&date=2021&doi=10.1177%2F1099800420942900&pmid=32762338&sid=OVID:medline
+
+<1058>
+Unique Identifier
+ 32748635
+Title
+ IL-6 and Soluble Receptors in Overweight and Obese African American Women With and Without Breast Cancer.
+Source
+ Biological Research for Nursing. 23(2):218-222, 2021 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Griffith KA; Ryan AS
+Author NameID
+ Griffith, K A; ORCID: https://orcid.org/0000-0003-2091-2018
+Authors Full Name
+ Griffith, K A; Ryan, A S.
+Institution
+ Griffith, K A. 8367The George Washington University Schools of Nursing and Medicine and George Washington University Cancer Center, Washington, DC, USA.
+ Griffith, K A. Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
+ Ryan, A S. Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
+ Ryan, A S. Division of Gerontology and Geriatric Medicine, Geriatric Research, Education, and Clinical Center, University of Maryland School of Medicine, Baltimore, MD, USA.
+MeSH Subject Headings
+ Adult
+ *Black or African American/sn [Statistics & Numerical Data]
+ Biomarkers/bl [Blood]
+ *Breast Neoplasms/bl [Blood]
+ Breast Neoplasms/eh [Ethnology]
+ Female
+ Glycoproteins/bl [Blood]
+ Humans
+ *Interleukin-6/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/eh [Ethnology]
+ *Overweight/bl [Blood]
+ Overweight/eh [Ethnology]
+ *Receptors, Interleukin-6/bl [Blood]
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ breast cancer
+ health care disparities
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Interleukin 6 (IL-6) and its receptors are expressed in approximately half of breast cancer (BC) tissues, and high serum IL-6 levels are associated with poor prognosis. African American (AA) patients with BC have higher serum IL-6 levels compared to Caucasians, suggesting additional risk of disease-related complications in AAs. The purpose of this study was to compare IL-6 complex biomarkers in AA women with and without a history of BC. We conducted a secondary analysis of phenotypic data from two studies of weight loss in AA women with and without a history of BC who had similar age and adiposity. Biomarkers analyzed included tumor necrosis factor alpha (TNF-alpha), IL-6, IL-6 soluble receptor (IL6sr), and soluble glycoprotein 130 (GP130); IL6sr and GP130 were newly analyzed for this study. TNF-alpha levels were 1.86 times higher in the BC group (N = 7) compared to those without BC (N = 10; p < 0.001) despite similar age, weight, and body mass index. GP130 levels tended to be higher in women with BC; IL-6 and Il-6 sr were not different between groups. There was a strong correlation between GP130 and TNF-alpha (r = .638; p = .006) in the group overall. High TNF-alpha levels in the BC group and a strong correlation between GP130 and TNF-alpha in the overall group suggest the presence of IL-6 complex initiated TNF-alpha production. Further study is needed to evaluate IL-6 reduction through a variety of approaches, including weight loss and anti-IL-6 therapies, which may ultimately implicate the reduction of IL-6 complex associated BC-specific recurrence and mortality.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycoproteins). 0 (Interleukin-6). 0 (Receptors, Interleukin-6). 0 (Tumor Necrosis Factor-alpha). 0 (glycoprotein 130, human).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1177%2f1099800420945787
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Griffith&issn=1099-8004&title=Biological+Research+for+Nursing&atitle=IL-6+and+Soluble+Receptors+in+Overweight+and+Obese+African+American+Women+With+and+Without+Breast+Cancer.&volume=23&issue=2&spage=218&epage=222&date=2021&doi=10.1177%2F1099800420945787&pmid=32748635&sid=OVID:medline
+
+<1059>
+Unique Identifier
+ 32681271
+Title
+ Leptin level as a biomarker of uncontrolled eating in obesity and overweight.
+Source
+ Irish Journal of Medical Science. 190(1):155-161, 2021 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Benbaibeche H; Bounihi A; Koceir EA
+Author NameID
+ Benbaibeche, Hassiba; ORCID: http://orcid.org/0000-0001-9830-0332
+Authors Full Name
+ Benbaibeche, Hassiba; Bounihi, Abdenour; Koceir, Elhadj Ahmed.
+Institution
+ Benbaibeche, Hassiba. Departement des Sciences de la Nature et de la Vie, Faculte des Sciences, Universite D'Alger, Algiers, Algeria. benbaibecheh@yahoo.fr.
+ Benbaibeche, Hassiba. Bioenergetics and Intermediary Metabolism team, Biology and Organisms Physiology laboratory, Biological Sciences Faculty, University of Sciences and Technology Houari Boumediene (USTHB), El Alia, Bab Ezzouar, 16123, Algiers, Algeria. benbaibecheh@yahoo.fr.
+ Bounihi, Abdenour. Bioenergetics and Intermediary Metabolism team, Biology and Organisms Physiology laboratory, Biological Sciences Faculty, University of Sciences and Technology Houari Boumediene (USTHB), El Alia, Bab Ezzouar, 16123, Algiers, Algeria.
+ Bounihi, Abdenour. Department of Second Cycle, Ecole Superieure des Sciences de l'Aliment et des Industries Agroalimentaires, Algiers, Algeria.
+ Koceir, Elhadj Ahmed. Bioenergetics and Intermediary Metabolism team, Biology and Organisms Physiology laboratory, Biological Sciences Faculty, University of Sciences and Technology Houari Boumediene (USTHB), El Alia, Bab Ezzouar, 16123, Algiers, Algeria.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Feeding Behavior/px [Psychology]
+ Female
+ Humans
+ *Leptin/bl [Blood]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Overweight/bl [Blood]
+ Overweight/di [Diagnosis]
+ Surveys and Questionnaires
+Keyword Heading
+ Insulin resistance
+ Leptin
+ Obesity
+ Overweight
+ Uncontrolled eating
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Uncontrolled eating (UE) showed important relationships with the development of obesity. Homeostatic regulations of feeding and energy balance, as well as hedonic eating, are regulated by leptin.
+
+ AIMS: The aims of this study were (1) to assess eating behaviors of Algerian adults as measured by the 51-item eating inventory; we also evaluate changes in the Three-Factor Eating Questionnaire (TFEQ) scores according to the body mass index (BMI) category; (2) to examine the association between the scores of the three TFEQ factors and the BMI values of the participants; and (3) to examine whether leptin concentrations are associated with eating behavior. Our hypothesis is that participants with obesity and high concentrations of leptin might display uncontrolled eating behavior.
+
+ METHODS: The subjects were 190 participants (60 obese, 60 overweight, and 70 lean subjects). The eating behavior was measured by using the 51-item eating inventory. Serum insulin concentrations were assessed by radioimmunoassay and were used to calculate homeostasis model assessment (HOMA). Serum leptin was quantified by the enzyme-linked immunosorbent assay (ELISA).
+
+ RESULTS: Obese and overweight subjects showed hyperphagic behavior, i.e., uncontrolled eating. The logistic regression analysis showed an effect of leptin, HOMA, uncontrolled eating, and emotional eating on BMI. Leptin levels were associated with the uncontrolled eating and influenced by insulin sensitivity.
+
+ CONCLUSIONS: The uncontrolled eating reflects hyperphagic eating behavior in obese and overweight subjects. Coexistence of uncontrolled eating and high level of leptin demonstrates a state of leptin resistance resulting in an inability to detect satiety. High circulating leptin can be considered a potential biomarker of uncontrolled eating.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1007%2fs11845-020-02316-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Benbaibeche&issn=0021-1265&title=Irish+Journal+of+Medical+Science&atitle=Leptin+level+as+a+biomarker+of+uncontrolled+eating+in+obesity+and+overweight.&volume=190&issue=1&spage=155&epage=161&date=2021&doi=10.1007%2Fs11845-020-02316-1&pmid=32681271&sid=OVID:medline
+
+<1060>
+Unique Identifier
+ 32617979
+Title
+ Enalapril and treadmill running reduce adiposity, but only the latter causes adipose tissue browning in mice.
+Source
+ Journal of Cellular Physiology. 236(2):900-910, 2021 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Giori IG; Magliano DC; Alexandre-Santos B; Fernandes T; Oliveira EM; Vieira CP; Conte-Junior CA; Ceddia RB; Nobrega ACL; Frantz EDC
+Author NameID
+ Magliano, D'Angelo C; ORCID: https://orcid.org/0000-0002-0575-961X
+ Ceddia, Rolando B; ORCID: https://orcid.org/0000-0002-8888-1281
+ Nobrega, Antonio C L; ORCID: https://orcid.org/0000-0002-3830-2886
+ Frantz, Eliete D C; ORCID: https://orcid.org/0000-0002-1747-5614
+Authors Full Name
+ Giori, Isabele G; Magliano, D'Angelo C; Alexandre-Santos, Beatriz; Fernandes, Tiago; Oliveira, Edilamar M; Vieira, Carla P; Conte-Junior, Carlos A; Ceddia, Rolando B; Nobrega, Antonio C L; Frantz, Eliete D C.
+Institution
+ Giori, Isabele G. Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Magliano, D'Angelo C. Laboratory of Morphological and Metabolic Analyses, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Alexandre-Santos, Beatriz. Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Alexandre-Santos, Beatriz. Laboratory of Morphological and Metabolic Analyses, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Fernandes, Tiago. National Institute for Science and Technology, INCT Physical (In)activity and Exercise, CNPq, Niteroi, Rio de Janeiro, Brazil.
+ Fernandes, Tiago. Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, State of Sao Paulo, Brazil.
+ Oliveira, Edilamar M. National Institute for Science and Technology, INCT Physical (In)activity and Exercise, CNPq, Niteroi, Rio de Janeiro, Brazil.
+ Oliveira, Edilamar M. Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, State of Sao Paulo, Brazil.
+ Vieira, Carla P. Department of Food Technology, Faculty of Veterinary, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Conte-Junior, Carlos A. Department of Food Technology, Faculty of Veterinary, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Ceddia, Rolando B. Muscle Health Research Center, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
+ Nobrega, Antonio C L. Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Nobrega, Antonio C L. National Institute for Science and Technology, INCT Physical (In)activity and Exercise, CNPq, Niteroi, Rio de Janeiro, Brazil.
+ Frantz, Eliete D C. Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Frantz, Eliete D C. Laboratory of Morphological and Metabolic Analyses, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
+ Frantz, Eliete D C. National Institute for Science and Technology, INCT Physical (In)activity and Exercise, CNPq, Niteroi, Rio de Janeiro, Brazil.
+MeSH Subject Headings
+ *Adipose Tissue, Brown/de [Drug Effects]
+ Adipose Tissue, Brown/me [Metabolism]
+ *Adipose Tissue, Brown/pp [Physiopathology]
+ Adipose Tissue, White/me [Metabolism]
+ Adipose Tissue, White/pp [Physiopathology]
+ *Adiposity/de [Drug Effects]
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Enalapril/pd [Pharmacology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ *Physical Conditioning, Animal/ph [Physiology]
+ Renin-Angiotensin System/de [Drug Effects]
+ *Running/ph [Physiology]
+ *Subcutaneous Fat/de [Drug Effects]
+ Subcutaneous Fat/me [Metabolism]
+ Subcutaneous Fat/pp [Physiopathology]
+Keyword Heading
+ aerobic exercise training
+ browning
+ renin-angiotensin system
+ white adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study investigated whether regulation of the renin-angiotensin system (RAS) by enalapril and/or aerobic exercise training (AET) causes browning of the subcutaneous white adipose tissue (sWAT). C57BL/6 mice were fed either a standard chow or a high-fat (HF) diet for 16 weeks. At Week 8, HF-fed animals were divided into sedentary (HF), enalapril (HF-E), AET (HF-T), and enalapril plus AET (HF-ET) groups. Subsequently, sWAT was extracted for morphometry, determination of RAS expression, and biomarkers of WAT browning. The HF group displayed adipocyte hypertrophy and induction of the classical RAS axis. Conversely, all interventions reduced adiposity and induced the counterregulatory RAS axis. However, only AET raised plasma irisin, increased peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and uncoupling protein-1 levels, and the expression of PR-domain containing 16 in sWAT. Therefore, we concluded that AET-induced sWAT browning was independent of the counterregulatory axis shifting of RAS in HF diet-induced obesity. Copyright © 2020 Wiley Periodicals LLC.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 69PN84IO1A (Enalapril).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1002%2fjcp.29900
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Giori&issn=0021-9541&title=Journal+of+Cellular+Physiology&atitle=Enalapril+and+treadmill+running+reduce+adiposity%2C+but+only+the+latter+causes+adipose+tissue+browning+in+mice.&volume=236&issue=2&spage=900&epage=910&date=2021&doi=10.1002%2Fjcp.29900&pmid=32617979&sid=OVID:medline
+
+<1061>
+Unique Identifier
+ 32557741
+Title
+ Clinical profile of non-alcoholic fatty liver disease in nonobese patients.
+Source
+ Journal of Gastroenterology & Hepatology. 36(1):257-261, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lum JHM; Cheah MCC; Leow WQ; Wan WK; Lim TKH; Chow WC; Chang JPE; Goh GBB
+Author NameID
+ Lum, Johnathan Huey Ming; ORCID: https://orcid.org/0000-0001-8817-7844
+Authors Full Name
+ Lum, Johnathan Huey Ming; Cheah, Mark Chang Chuen; Leow, Wei Qiang; Wan, Wei Keat; Lim, Tony Kiat Hon; Chow, Wan Cheng; Chang, Jason Pik Eu; Goh, George Boon Bee.
+Institution
+ Lum, Johnathan Huey Ming. Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
+ Cheah, Mark Chang Chuen. Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
+ Leow, Wei Qiang. Department of Anatomical Pathology, Singapore General Hospital, Singapore.
+ Wan, Wei Keat. Department of Anatomical Pathology, Singapore General Hospital, Singapore.
+ Lim, Tony Kiat Hon. Department of Anatomical Pathology, Singapore General Hospital, Singapore.
+ Chow, Wan Cheng. Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
+ Chow, Wan Cheng. Medicine Academic Clinical Program, Duke-NUS Medical School, Singapore.
+ Chang, Jason Pik Eu. Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
+ Chang, Jason Pik Eu. Medicine Academic Clinical Program, Duke-NUS Medical School, Singapore.
+ Goh, George Boon Bee. Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
+ Goh, George Boon Bee. Medicine Academic Clinical Program, Duke-NUS Medical School, Singapore.
+MeSH Subject Headings
+ Adult
+ Aged
+ Asian People
+ Aspartate Aminotransferases/bl [Blood]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cohort Studies
+ Female
+ Humans
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/et [Etiology]
+ Liver Cirrhosis/pa [Pathology]
+ Male
+ Metabolic Syndrome/co [Complications]
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease
+ *Obesity
+ Organ Dysfunction Scores
+ Platelet Count
+ Risk
+Keyword Heading
+ Singapore
+ body mass index
+ non-alcoholic fatty liver disease
+ non-alcoholic steatohepatitis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome. Worryingly, it has been increasingly reported among nonobese patients. This study aims to analyse patient characteristics of biopsy-proven NAFLD in an Asian cohort and explore differences stratified by body mass index (BMI).
+
+ METHODS: Clinical, laboratory, and histological data were collected from 263 adults with biopsy-proven NAFLD. Patients with and without obesity (BMI cut-off 25) were compared. The ability to predict advanced liver fibrosis with three non-invasive scores, the NAFLD Fibrosis score (NFS), Fibrosis-4 (FIB4), and the aspartate aminotransferase to platelet ratio index (APRI), was compared.
+
+ RESULTS: Obese subjects had a lower mean age (49.5 +/- 12.5 vs 54.0 +/- 12.9 years, P = 0.017), a higher prevalence of diabetes (52.4% vs 36.8%, P = 0.037), and a higher waist circumference (113.9 +/- 16.0 cm vs 87.0 +/- 18.4 cm, P = 0.022). The prevalence of dyslipidaemia (68.0% vs 61.4%, P = 0.353) and hypertension (61.7% vs 49.1%, P = 0.190) was comparable between the two groups. The distribution of non-alcoholic steatohepatitis (NASH) (63.1% versus 61.4%, P = 0.710) and advanced fibrosis (31.6% versus 26.3%, P = 0.447) were also similar in both groups. All three non-invasive scores (NFS, FIB4, and APRI) performed poorly in predicting advanced fibrosis in nonobese patients with NAFLD. The FIB4 was the most accurate non-invasive score in predicting advanced fibrosis in the obese group.
+
+ CONCLUSIONS: Obese and nonobese patients are equally at risk of NASH and advanced fibrosis. While the FIB4 is the most accurate non-invasive score in predicting advanced fibrosis among obese individuals, further research is warranted to develop a nonobese specific score to correctly identify nonobese NAFLD patients with advanced fibrosis. Copyright © 2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-1 (Aspartate Aminotransferases).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fjgh.15154
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lum&issn=0815-9319&title=Journal+of+Gastroenterology+%26+Hepatology&atitle=Clinical+profile+of+non-alcoholic+fatty+liver+disease+in+nonobese+patients.&volume=36&issue=1&spage=257&epage=261&date=2021&doi=10.1111%2Fjgh.15154&pmid=32557741&sid=OVID:medline
+
+<1062>
+Unique Identifier
+ 32544011
+Title
+ The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
+Source
+ Gynecological Endocrinology. 37(1):26-30, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B
+Authors Full Name
+ Taghizadeh, Shiva; Izadi, Azimeh; Shirazi, Shabnam; Parizad, Marziyeh; Pourghassem Gargari, Bahram.
+Institution
+ Taghizadeh, Shiva. Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Taghizadeh, Shiva. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Izadi, Azimeh. Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Izadi, Azimeh. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Shirazi, Shabnam. Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Shirazi, Shabnam. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Parizad, Marziyeh. Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Pourghassem Gargari, Bahram. Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Dietary Supplements
+ Double-Blind Method
+ *Endothelium, Vascular/de [Drug Effects]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/co [Complications]
+ *Inflammation/dt [Drug Therapy]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/co [Complications]
+ *Polycystic Ovary Syndrome/dt [Drug Therapy]
+ *Ubiquinone/aa [Analogs & Derivatives]
+ Ubiquinone/pd [Pharmacology]
+ Ubiquinone/tu [Therapeutic Use]
+ Vitamins/pd [Pharmacology]
+ *Vitamins/tu [Therapeutic Use]
+ Young Adult
+Keyword Heading
+ Coenzyme Q10 polycystic ovary syndrome adhesion molecules inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: This study aimed at determining the effects of coenzyme Q10 (CoQ10) supplementation on the inflammatory and endothelial dysfunction indices among overweight and obese women with polycystic ovary syndrome (PCOS).
+
+ METHODS: This randomized double-blind, placebo-controlled clinical trial was performed among overweight and obese women diagnosed with PCOS. Forty three PCOS women were randomly assigned to two groups: one group received 200 mg CoQ10 capsules per day (n = 22) and the other received placebo (n = 21) for 8 weeks. Biomarkers of inflammation and endothelial dysfunction including high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin were measured and compared before and after the intervention.
+
+ RESULTS: At the end of study, compared with pldacebo, CoQ10 supplementation resulted in significant decreases in serum levels of TNF-alpha (p = 0.009), hs-CRP and IL-6 (p = 0.001, p = 0.007, respectively). In addition, supplementation with CoQ10 resulted in a significant reduction in serum VCAM-1 (p = .002) and E-selectin (p = .006) compared with the control group. There were no significant differences for serum ICAM-1.
+
+ CONCLUSIONS: The present study showed that CoQ10 supplementation for 8 weeks had a beneficial effect on inflammatory and endothelial dysfunction markers in overweight and obese patients with PCOS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Vitamins). 1339-63-5 (Ubiquinone). EJ27X76M46 (coenzyme Q10).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1080%2f09513590.2020.1779689
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Taghizadeh&issn=0951-3590&title=Gynecological+Endocrinology&atitle=The+effect+of+coenzyme+Q10+supplementation+on+inflammatory+and+endothelial+dysfunction+markers+in+overweight%2Fobese+polycystic+ovary+syndrome+patients.&volume=37&issue=1&spage=26&epage=30&date=2021&doi=10.1080%2F09513590.2020.1779689&pmid=32544011&sid=OVID:medline
+
+<1063>
+Unique Identifier
+ 32531868
+Title
+ Inverse correlation between serum high-molecular-weight adiponectin and proinsulin level in a Japanese population: The Dynamics of Lifestyle and Neighborhood Community on Health Study.
+Source
+ Journal of Diabetes Investigation. 12(1):63-66, 2021 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nakamura A; Miyoshi H; Ukawa S; Nakamura K; Nakagawa T; Terauchi Y; Tamakoshi A; Atsumi T
+Author NameID
+ Nakamura, Akinobu; ORCID: https://orcid.org/0000-0002-8192-0006
+ Miyoshi, Hideaki; ORCID: https://orcid.org/0000-0002-5909-3243
+Authors Full Name
+ Nakamura, Akinobu; Miyoshi, Hideaki; Ukawa, Shigekazu; Nakamura, Koshi; Nakagawa, Takafumi; Terauchi, Yasuo; Tamakoshi, Akiko; Atsumi, Tatsuya.
+Institution
+ Nakamura, Akinobu. Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
+ Miyoshi, Hideaki. Division of Diabetes and Obesity, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
+ Ukawa, Shigekazu. Department of Public Health, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
+ Ukawa, Shigekazu. Research Unit of Advanced Interdisciplinary Care Science, Osaka City University Graduate School of Human Life Science, Osaka, Japan.
+ Nakamura, Koshi. Department of Public Health, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
+ Nakamura, Koshi. Department of Public Health and Hygiene, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
+ Nakagawa, Takafumi. The Hokkaido Centre for Family Medicine, Sapporo, Japan.
+ Terauchi, Yasuo. Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
+ Tamakoshi, Akiko. Department of Public Health, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
+ Atsumi, Tatsuya. Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Secretion
+ Japan
+ *Life Style
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ *Proinsulin/bl [Blood]
+Keyword Heading
+ Adiponectin
+ Pancreatic beta-cells
+ Proinsulin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Serum high-molecular-weight adiponectin (HMWA) has a positive correlation with insulin secretion in the Japanese population. To validate this correlation, we investigated the correlation between serum HMWA and proinsulin, a marker of beta-cell dysfunction, in this population. A total of 488 participants (53.9% women) aged 35-79 years not taking oral hypoglycemic agents and/or insulin were enrolled. HMWA was significantly and inversely correlated with proinsulin adjusted for age and sex (partial regression coefficient beta = -0.37; 95% confidence interval -0.46 to -0.28). When the participants were divided into two groups by median values of body mass index (23.2 kg/m2 ), serum insulin (4.3 microU/mL) or homeostasis model assessment of insulin resistance (1.0), similar inverse correlations were observed adjusted for age and sex in both groups. Our results showed that the HMWA level was inversely correlated with the proinsulin level in a general Japanese population. Copyright © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 9035-68-1 (Proinsulin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1111%2fjdi.13323
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nakamura&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Inverse+correlation+between+serum+high-molecular-weight+adiponectin+and+proinsulin+level+in+a+Japanese+population%3A+The+Dynamics+of+Lifestyle+and+Neighborhood+Community+on+Health+Study.&volume=12&issue=1&spage=63&epage=66&date=2021&doi=10.1111%2Fjdi.13323&pmid=32531868&sid=OVID:medline
+
+<1064>
+Unique Identifier
+ 32513316
+Title
+ Higher ultra-processed food intake is associated with higher DNA damage in healthy adolescents.
+Source
+ British Journal of Nutrition. 125(5):568-576, 2021 03 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Edalati S; Bagherzadeh F; Asghari Jafarabadi M; Ebrahimi-Mamaghani M
+Author NameID
+ Edalati, Sareh; ORCID: https://orcid.org/0000-0002-4050-4372
+Authors Full Name
+ Edalati, Sareh; Bagherzadeh, Farzaneh; Asghari Jafarabadi, Mohammad; Ebrahimi-Mamaghani, Mehrangiz.
+Institution
+ Edalati, Sareh. Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran1981619573, Iran.
+ Bagherzadeh, Farzaneh. Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz5165665931, Iran.
+ Asghari Jafarabadi, Mohammad. Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz5165665931, Iran.
+ Ebrahimi-Mamaghani, Mehrangiz. Social Determinant of Health Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz5165665931, Iran.
+MeSH Subject Headings
+ 8-Hydroxy-2'-Deoxyguanosine/ur [Urine]
+ Adolescent
+ Biomarkers/ur [Urine]
+ Body Mass Index
+ *DNA Damage
+ *Diet
+ Edible Grain
+ Energy Intake
+ Female
+ *Food Handling/mt [Methods]
+ Humans
+ Iran/ep [Epidemiology]
+ Male
+ Obesity/ep [Epidemiology]
+ Sex Factors
+ Young Adult
+Keyword Heading
+ 8-Hydroxy-2'-deoxyguanosine
+ Adolescents
+ Commercial determinants of health
+ DNA damage
+ Food-processing industry
+ Oxidative stress
+ Ultra-processed food
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Ultra-processed food is one of the main contributors to energy supply and consumption in food systems worldwide, and evidence of their detrimental health outcomes in humans is emerging. This study aimed to assess ultra-processed food intake and its association with urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage, in 139 healthy adolescents in Karaj City in Iran. Usual dietary intake was measured using a 168-item validated FFQ. The daily intake of ultra-processed food consumption was determined through the classification of NOVA, and general linear models were used to compare the urinary levels of 8-OHdG/creatinine (ng/mg creatinine) within tertiles of ultra-processed food intake. Adolescents in the higher tertile of ultra-processed food consumption had a significantly higher mean level of urinary 8-OHdG/creatinine in comparison with the lower tertiles in the crude model (Pfor trend: 0.003) and after adjustment for confounding variables, including total energy intake, sex, age, BMI for age Z-score, obesity and physical activity (Pfor trend: 0.004). This association was still significant after adjusting for dietary intake of whole grains, nuts, legumes, the ratio of MUFA:SFA (g/d) and Mediterranean dietary score (Pfor trend: 0.002). More studies are needed to explore the determinants of ultra-processed food supply, demand, consumption and health effects; such studies should be applied to develop evidence-informed policies and regulatory mechanisms to improve children's and adolescents' food environment policymaking and legislation with special attention to ultra-processed food.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1017%2fS0007114520001981
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Edalati&issn=0007-1145&title=British+Journal+of+Nutrition&atitle=Higher+ultra-processed+food+intake+is+associated+with+higher+DNA+damage+in+healthy+adolescents.&volume=125&issue=5&spage=568&epage=576&date=2021&doi=10.1017%2FS0007114520001981&pmid=32513316&sid=OVID:medline
+
+<1065>
+Unique Identifier
+ 31412378
+Title
+ Circulating CTRP6 Levels are Increased in Overweight or Obese Chinese Individuals and Associated with Insulin Resistance Parameters: A Pilot Study.
+Source
+ Experimental & Clinical Endocrinology & Diabetes. 129(7):535-541, 2021 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liao X; Liu S; Tang X; Yang D; Liu H; Gao L; Yang G
+Authors Full Name
+ Liao, Xin; Liu, Sha; Tang, Xuejiao; Yang, Dan; Liu, Hua; Gao, Lin; Yang, Gangyi.
+Institution
+ Liao, Xin. Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China.
+ Liu, Sha. Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China.
+ Tang, Xuejiao. Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
+ Yang, Dan. Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China.
+ Liu, Hua. Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
+ Gao, Lin. Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China.
+ Yang, Gangyi. Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Guizhou, China.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ China
+ *Collagen/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Overweight/bl [Blood]
+ Overweight/di [Diagnosis]
+ Pilot Projects
+Abstract
+ AIMS: CTRP6, a newly discovered adipokine, has been found to be a regulator for energy homeostasis. However, the association between circulating CTRP6 and obesity in humans is still unclear.
+
+ METHODS: 256 individuals, including 185 overweight/obese (OW/OB) and 71 normal weight adults, were recruited for this study. Circulating concentrations of CTRP6 and adiponectin (Adipoq) were examined by ELISA.
+
+ RESULTS: Serum CTRP6 levels in obese individuals were significantly increased compared with those in healthy individuals (506.1+/-134.9 vs.363.3+/-80.5 ng/mL, P<0.01). Conversely, serum Adipoq concentrations in OW/OB individuals were markedly decreased compared with healthy controls [20.8 (12.1-29.3) vs. 14.1 ( 8.61-17.7) ; P<0.01]. Correlation analysis revealed that there was a positive relationship between circulating CTRP6 and age, BMI, Fat%, LDL-C, TG, WHR, TC, FBG, FIns, HOMA-IR and HbA1c, but there was an inverse correlation with Adipoq and HDL-C. Logistic regression analysis revealed that high serum CTRP6 levels are markedly associated with OW/OB. Finally, ROC curve analysis showed that the cut-off value for serum CTRP6 for prediction of IR is 518 ng/mL.
+
+ CONCLUSIONS: CTRP6 may be a marker related to OW/OB. Copyright Thieme. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (C1qTNF6 protein, human). 9007-34-5 (Collagen).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2021
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med19&DO=10.1055%2fa-0929-6072
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liao&issn=0947-7349&title=Experimental+%26+Clinical+Endocrinology+%26+Diabetes&atitle=Circulating+CTRP6+Levels+are+Increased+in+Overweight+or+Obese+Chinese+Individuals+and+Associated+with+Insulin+Resistance+Parameters%3A+A+Pilot+Study.&volume=129&issue=7&spage=535&epage=541&date=2021&doi=10.1055%2Fa-0929-6072&pmid=31412378&sid=OVID:medline
+
+<1066>
+Unique Identifier
+ 33326480
+Title
+ Clinical outcomes and inflammatory marker levels in patients with Covid-19 and obesity at an inner-city safety net hospital.
+Source
+ PLoS ONE [Electronic Resource]. 15(12):e0243888, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mostaghim A; Sinha P; Bielick C; Knudsen S; Beeram I; White LF; Apovian C; Sagar M; Hochberg NS
+Author NameID
+ Mostaghim, Anahita; ORCID: https://orcid.org/0000-0002-5790-9288
+ Bielick, Catherine; ORCID: https://orcid.org/0000-0003-1871-3909
+ White, Laura F; ORCID: https://orcid.org/0000-0002-0588-8235
+ Hochberg, Natasha S; ORCID: https://orcid.org/0000-0002-5449-9973
+Authors Full Name
+ Mostaghim, Anahita; Sinha, Pranay; Bielick, Catherine; Knudsen, Selby; Beeram, Indeevar; White, Laura F; Apovian, Caroline; Sagar, Manish; Hochberg, Natasha S.
+Institution
+ Mostaghim, Anahita. Department of Internal Medicine, School of Medicine, Boston University, Boston, Massachusetts, United States of America.
+ Sinha, Pranay. Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Boston University, Boston, Massachusetts, United States of America.
+ Bielick, Catherine. Department of Internal Medicine, School of Medicine, Boston University, Boston, Massachusetts, United States of America.
+ Knudsen, Selby. Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Boston University, Boston, Massachusetts, United States of America.
+ Beeram, Indeevar. School of Medicine, Boston University, Boston, Massachusetts, United States of America.
+ White, Laura F. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
+ Apovian, Caroline. Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Internal Medicine, School of Medicine, Boston University, Boston, Massachusetts, United States of America.
+ Sagar, Manish. Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Boston University, Boston, Massachusetts, United States of America.
+ Hochberg, Natasha S. Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Boston University, Boston, Massachusetts, United States of America.
+ Hochberg, Natasha S. Boston Medical Center, Boston, Massachusetts, United States of America.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ *Biomarkers/me [Metabolism]
+ Body Mass Index
+ COVID-19/co [Complications]
+ COVID-19/mo [Mortality]
+ *COVID-19/pa [Pathology]
+ COVID-19/vi [Virology]
+ Female
+ Hospital Mortality
+ Humans
+ Intensive Care Units
+ Logistic Models
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Odds Ratio
+ Retrospective Studies
+ Risk Factors
+ SARS-CoV-2/ip [Isolation & Purification]
+ *Safety-net Providers
+ Treatment Outcome
+Abstract
+ OBJECTIVES: Patients with Covid-19 and obesity have worse clinical outcomes which may be driven by increased inflammation. This study aimed to characterize the association between clinical outcomes in patients with obesity and inflammatory markers.
+
+ METHODS: We analyzed data for patients aged >=18 years admitted with a positive SARS-CoV-2 PCR test. We used multivariate logistic regression to determine the association between BMI and intensive care unit (ICU) transfer and all-cause mortality. Inflammatory markers (C-reactive protein [CRP], lactate dehydrogenase [LDH], ferritin, and D-dimer) were compared between patients with and without obesity (body mass index [BMI] >=30 kg/m2).
+
+ RESULTS: Of 791 patients with Covid-19, 361 (45.6%) had obesity. In multivariate analyses, BMI >=35 was associated with a higher odds of ICU transfer (adjusted odds ratio [aOR] 2.388 (95% confidence interval [CI]: 1.074-5.310) and hospital mortality (aOR = 4.3, 95% CI: 1.69-10.82). Compared to those with BMI<30, patients with obesity had lower ferritin (444 vs 637 ng/mL; p<0.001) and lower D-dimer (293 vs 350 mcg/mL; p = 0.009), non-significant differences in CRP (72.8 vs 84.1 mg/L, p = 0.099), and higher LDH (375 vs 340, p = 0.009) on the first hospital day.
+
+ CONCLUSIONS: Patients with obesity were more likely to have poor outcomes even without increased inflammation.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0243888
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mostaghim&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Clinical+outcomes+and+inflammatory+marker+levels+in+patients+with+Covid-19+and+obesity+at+an+inner-city+safety+net+hospital.&volume=15&issue=12&spage=e0243888&epage=&date=2020&doi=10.1371%2Fjournal.pone.0243888&pmid=33326480&sid=OVID:medline
+
+<1067>
+Unique Identifier
+ 33270666
+Title
+ CTRP3 and serum triglycerides in children aged 7-10 years.
+Source
+ PLoS ONE [Electronic Resource]. 15(12):e0241813, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alamian A; Marrs JA; Clark WA; Thomas KL; Peterson JM
+Author NameID
+ Peterson, Jonathan M; ORCID: https://orcid.org/0000-0002-9873-3880
+Authors Full Name
+ Alamian, Arsham; Marrs, Jo-Ann; Clark, W Andrew; Thomas, Kristy L; Peterson, Jonathan M.
+Institution
+ Alamian, Arsham. School of Nursing and Health Studies, University of Miami, Coral Gables, Florida, United States of America.
+ Marrs, Jo-Ann. College of Nursing, East Tennessee State University, Johnson City, Tennessee, United States of America.
+ Clark, W Andrew. College of Clinical and Rehabilitative Health Sciences, East Tennessee State University, Johnson City, Tennessee, United States of America.
+ Thomas, Kristy L. Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America.
+ Peterson, Jonathan M. Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America.
+ Peterson, Jonathan M. Department of Health Sciences, College of Public Health, East Tennessee State University, Johnson City, Tennessee, United States of America.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Child
+ Female
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance/ge [Genetics]
+ Leptin/bl [Blood]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ *Triglycerides/bl [Blood]
+ *Tumor Necrosis Factors/bl [Blood]
+Abstract
+ INTRODUCTION: The prevalence of obesity-related disorders has been steadily increasing over the past couple of decades. Diseases that were once only detected in adults are now prevalent in children, such as hyperlipidemia. The adipose tissue-derived hormonal factor C1q TNF Related Protein 3 (CTRP3) has been linked to triglyceride regulation especially in animal models. However, the relationship between circulating CTRP3 levels and obesity-related disorders in human subjects is controversial. CTRP3 can circulate in different oligomeric complexes: trimeric (<100 kDa), middle molecular weight (100-300 kDa), and high molecular weight (HMW) oligomeric complexes (>300 kDa). Previous work has identified that it is not the total amount of CTRP3 present in the serum, but the specific circulating oligomeric complexes that appear to be indicative of the relationship between CTRP3 and serum lipids levels. However, this work has not been examined in children. Therefore, the purpose of this study was to compare the levels of different oligomeric complexes of CTRP3 and circulating lipid levels among young children (aged 7-10 years).
+
+ METHODS: Morphometric data and serum samples were collected and analyzed from a cross-sectional population of 62 children of self-identified Hispanic origin from a community health center, between 2015 and 2016. Serum analysis included adiponectin, insulin, leptin, ghrelin, glucagon, C-reactive peptide, triglyceride, cholesterol, IL-6, TNF, and CTRP3. Correlation analyses were conducted to explore the relationships between CTRP3 and other biomarkers.
+
+ RESULTS: Total CTRP3 concentrations were significantly positively correlated with total cholesterol and HDL cholesterol. Whereas, HMW CTRP3 was not significantly associated with any variable measured. Conversely, the middle molecular weight (MMW) CTRP3 was negatively correlated with triglycerides levels, and very low-density lipoprotein (VLDL), insulin, and body mass index (BMI). The negative correlations between MMW CTRP3 and triglycerides and VLDLs were particularly strong (r2 = -0.826 and -0.827, respectively).
+
+ CONCLUSION: Overall, these data indicate that the circulating oligomeric state of CTRP3 and not just total CTRP3 level is important for understanding the association between CTRP3 and metabolic diseases. Further, this work indicates that MMW CTRP3 plays an important role in triglyceride and VLDL regulation which requires further study.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (C1QTNF3 protein, human). 0 (Insulin). 0 (Leptin). 0 (Triglycerides). 0 (Tumor Necrosis Factors).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0241813
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alamian&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=CTRP3+and+serum+triglycerides+in+children+aged+7-10+years.&volume=15&issue=12&spage=e0241813&epage=&date=2020&doi=10.1371%2Fjournal.pone.0241813&pmid=33270666&sid=OVID:medline
+
+<1068>
+Unique Identifier
+ 33057385
+Title
+ Acanthosis nigricans as a composite marker of cardiometabolic risk and its complex association with obesity and insulin resistance in Mexican American children.
+Source
+ PLoS ONE [Electronic Resource]. 15(10):e0240467, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lopez-Alvarenga JC; Chittoor G; Paul SFD; Puppala S; Farook VS; Fowler SP; Resendez RG; Hernandez-Ruiz J; Diaz-Badillo A; Salazar D; Garza DD; Lehman DM; Mummidi S; Arya R; Jenkinson CP; Lynch JL; DeFronzo RA; Blangero J; Hale DE; Duggirala R
+Author NameID
+ Lopez-Alvarenga, Juan C; ORCID: https://orcid.org/0000-0002-0966-8766
+ Fowler, Sharon P; ORCID: https://orcid.org/0000-0003-1117-683X
+Authors Full Name
+ Lopez-Alvarenga, Juan C; Chittoor, Geetha; Paul, Solomon F D; Puppala, Sobha; Farook, Vidya S; Fowler, Sharon P; Resendez, Roy G; Hernandez-Ruiz, Joselin; Diaz-Badillo, Alvaro; Salazar, David; Garza, Doreen D; Lehman, Donna M; Mummidi, Srinivas; Arya, Rector; Jenkinson, Christopher P; Lynch, Jane L; DeFronzo, Ralph A; Blangero, John; Hale, Daniel E; Duggirala, Ravindranath.
+Institution
+ Lopez-Alvarenga, Juan C. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+ Chittoor, Geetha. Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, United States of America.
+ Paul, Solomon F D. Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.
+ Puppala, Sobha. Department of Internal Medicine, Wake Forest University, Winston-Salem, NC, United States of America.
+ Farook, Vidya S. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+ Fowler, Sharon P. Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, United States of America.
+ Resendez, Roy G. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+ Hernandez-Ruiz, Joselin. Department of Pharmacology, Hospital General de Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico.
+ Diaz-Badillo, Alvaro. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+ Salazar, David. Border Health Office, College of Health Professions, University of Texas Rio Grande Valley, Edinburg, TX, United States of America.
+ Garza, Doreen D. Border Health Office, College of Health Professions, University of Texas Rio Grande Valley, Edinburg, TX, United States of America.
+ Lehman, Donna M. Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, United States of America.
+ Mummidi, Srinivas. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+ Arya, Rector. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+ Jenkinson, Christopher P. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+ Lynch, Jane L. Department of Pediatrics, University of Texas Health San Antonio, San Antonio, TX, United States of America.
+ DeFronzo, Ralph A. Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, United States of America.
+ Blangero, John. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+ Hale, Daniel E. Pediatric Endocrinology and Diabetes, Penn State University, Hershey, PA, United States of America.
+ Duggirala, Ravindranath. Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, TX, United States of America.
+MeSH Subject Headings
+ *Acanthosis Nigricans/pp [Physiopathology]
+ Adolescent
+ Biomarkers/me [Metabolism]
+ *Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ Cardiovascular Diseases/pa [Pathology]
+ Child
+ Female
+ Humans
+ Incidence
+ *Insulin Resistance
+ Male
+ *Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pa [Pathology]
+ *Mexican Americans/sn [Statistics & Numerical Data]
+ Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ United States/ep [Epidemiology]
+Abstract
+ AIM: Acanthosis nigricans (AN) is a strong correlate of obesity and is considered a marker of insulin resistance (IR). AN is associated with various other cardiometabolic risk factors (CMRFs). However, the direct causal relationship of IR with AN in obesity has been debated. Therefore, we aimed to examine the complex causal relationships among the troika of AN, obesity, and IR in Mexican Americans (MAs).
+
+ METHODS: We used data from 670 non-diabetic MA children, aged 6-17 years (49% girls). AN (prevalence 33%) severity scores (range 0-5) were used as a quasi-quantitative trait (AN-q) for analysis. We used the program SOLAR for determining phenotypic, genetic, and environmental correlations between AN-q and CMRFs (e.g., BMI, HOMA-IR, lipids, blood pressure, hs-C-reactive protein (CRP), and Harvard physical fitness score (PFS)). The genetic and environmental correlations were subsequently used in mediation analysis (AMOS program). Model comparisons were made using goodness-of-fit indexes.
+
+ RESULTS: Heritability of AN-q was 0.75 (p<0.0001). It was positively/significantly (p<0.05) correlated with traits such as BMI, HOMA-IR, and CRP, and negatively with HDL-C and PFS. Of the models tested, indirect mediation analysis of BMI->HOMA-IR->AN-q yielded lower goodness-of-fit than a partial mediation model where BMI explained the relationship with both HOMA-IR and AN-q simultaneously. Using complex models, BMI was associated with AN-q and IR mediating most of the CMRFs; but no relationship between IR and AN-q.
+
+ CONCLUSION: Our study suggests that obesity explains the association of IR with AN, but no causal relationship between IR and AN in Mexican American children.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, American Recovery and Reinvestment Act. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0240467
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lopez-Alvarenga&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Acanthosis+nigricans+as+a+composite+marker+of+cardiometabolic+risk+and+its+complex+association+with+obesity+and+insulin+resistance+in+Mexican+American+children.&volume=15&issue=10&spage=e0240467&epage=&date=2020&doi=10.1371%2Fjournal.pone.0240467&pmid=33057385&sid=OVID:medline
+
+<1069>
+Unique Identifier
+ 33315915
+Title
+ Reduction of oxidative stress on DNA and RNA in obese patients after Roux-en-Y gastric bypass surgery-An observational cohort study of changes in urinary markers.
+Source
+ PLoS ONE [Electronic Resource]. 15(12):e0243918, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Carlsson ER; Fenger M; Henriksen T; Kjaer LK; Worm D; Hansen DL; Madsbad S; Poulsen HE
+Author NameID
+ Carlsson, Elin Rebecka; ORCID: https://orcid.org/0000-0002-8923-5943
+ Poulsen, Henrik Enghusen; ORCID: https://orcid.org/0000-0003-4242-9924
+Authors Full Name
+ Carlsson, Elin Rebecka; Fenger, Mogens; Henriksen, Trine; Kjaer, Laura Kofoed; Worm, Dorte; Hansen, Dorte Lindqvist; Madsbad, Sten; Poulsen, Henrik Enghusen.
+Institution
+ Carlsson, Elin Rebecka. Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
+ Carlsson, Elin Rebecka. Department of Clinical Biochemistry, Nordsjaellands Hospital, University of Copenhagen, Hilleroed, Denmark.
+ Fenger, Mogens. Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
+ Henriksen, Trine. Department of Clinical Pharmacology, Bispebjerg Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
+ Kjaer, Laura Kofoed. Department of Clinical Pharmacology, Bispebjerg Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
+ Worm, Dorte. Department of Medicine, Amager hospital, Copenhagen, Denmark.
+ Hansen, Dorte Lindqvist. Steno Diabetes Center Copenhagen, Gentofte, Denmark.
+ Madsbad, Sten. Department of Endocrinology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
+ Poulsen, Henrik Enghusen. Department of Clinical Pharmacology, Bispebjerg Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
+MeSH Subject Headings
+ 8-Hydroxy-2'-Deoxyguanosine/ch [Chemistry]
+ Adult
+ *Biomarkers/ur [Urine]
+ DNA/ip [Isolation & Purification]
+ DNA/ur [Urine]
+ Female
+ Gastric Bypass
+ Humans
+ Male
+ Middle Aged
+ Obesity/pa [Pathology]
+ Obesity/su [Surgery]
+ *Obesity/ur [Urine]
+ *Oxidative Stress/ge [Genetics]
+ RNA/ip [Isolation & Purification]
+ RNA/ur [Urine]
+Abstract
+ Increased oxidative stress in obesity and diabetes is associated with morbidity and mortality risks. Levels of oxidative damage to DNA and RNA can be estimated through measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) in urine. Both markers have been associated with type 2 diabetes, where especially 8-oxoGuo is prognostic for mortality risk. We hypothesized that Roux-en-Y gastric bypass (RYGB) surgery that has considerable effects on bodyweight, hyperglycemia and mortality, might be working through mechanisms that reduce oxidative stress, thereby reducing levels of the urinary markers. We used liquid chromatography coupled with tandem mass spectrometry to analyze the content of 8-oxodG and 8-oxoGuo in urinary samples from 356 obese patients treated with the RYGB-procedure. Mean age (SD) was 44.2 (9.6) years, BMI was 42.1 (5.6) kg/m2. Ninety-six (27%) of the patients had type 2 diabetes. Excretion levels of each marker before and after surgery were compared as estimates of the total 24-hour excretion, using a model based on glomerular filtration rate (calculated from cystatin C, age, height and weight), plasma- and urinary creatinine. The excretion of 8-oxodG increased in the first months after RYGB. For 8-oxoGuo, a gradual decrease was seen. Two years after RYGB and a mean weight loss of 35 kg, decreased hyperglycemia and insulin resistance, excretion levels of both markers were reduced by approximately 12% (P < 0.001). For both markers, mean excretion levels were about 30% lower in the female subgroup (P < 0.0001). Also, in this subgroup, excretion of 8-oxodG was significantly lower in patients with than without diabetes. We conclude, that oxidative damage to nucleic acids, reflected in the excretion of 8-oxodG and 8-oxoGuo, had decreased significantly two years after RYGB-indicating that reduced oxidative stress could be contributing to the many long-term benefits of RYGB-surgery in obesity and type 2 diabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 63231-63-0 (RNA). 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine). 9007-49-2 (DNA).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0243918
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Carlsson&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Reduction+of+oxidative+stress+on+DNA+and+RNA+in+obese+patients+after+Roux-en-Y+gastric+bypass+surgery-An+observational+cohort+study+of+changes+in+urinary+markers.&volume=15&issue=12&spage=e0243918&epage=&date=2020&doi=10.1371%2Fjournal.pone.0243918&pmid=33315915&sid=OVID:medline
+
+<1070>
+Unique Identifier
+ 33273564
+Title
+ Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.
+Source
+ Scientific Reports. 10(1):21102, 2020 12 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Choi JH; Kim MK; Yeo SH; Kim S
+Authors Full Name
+ Choi, Jun-Hui; Kim, Myung-Kon; Yeo, Soo-Hwan; Kim, Seung.
+Institution
+ Choi, Jun-Hui. Department of Food Science and Biotechnology, Gwangju University, Gwangju, 503-703, Republic of Korea.
+ Kim, Myung-Kon. Department of Food Science and Technology, Chonbuk National University, Iksan, 570-752, Republic of Korea.
+ Yeo, Soo-Hwan. Fermented Processing Food Science Division, Department of Agrofood Resource, National Academy of Agricultural Science, RDA, Wanju, 55365, Republic of Korea.
+ Kim, Seung. Department of Food Science and Biotechnology, Gwangju University, Gwangju, 503-703, Republic of Korea. seungk@gwangju.ac.kr.
+MeSH Subject Headings
+ *Acetic Acid/ad [Administration & Dosage]
+ Acetic Acid/pd [Pharmacology]
+ *Acetic Acid/tu [Therapeutic Use]
+ Animals
+ Biomarkers/bl [Blood]
+ Cell Line
+ Cell Survival/de [Drug Effects]
+ *Diet, High-Fat
+ Disease Models, Animal
+ Fenofibrate/pd [Pharmacology]
+ *Fruit/ch [Chemistry]
+ Humans
+ Lipid Metabolism/de [Drug Effects]
+ *Lipid Metabolism
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Mice, Obese
+ *Moraceae/ch [Chemistry]
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Organ Size/de [Drug Effects]
+ Oxidative Stress/de [Drug Effects]
+ Phosphorylation/de [Drug Effects]
+ Polyphenols/pd [Pharmacology]
+ Pomegranate/ch [Chemistry]
+ Signal Transduction/de [Drug Effects]
+ Weight Gain/de [Drug Effects]
+Abstract
+ Previous studies have suggested that vinegar intake can help to reduce body fat and hyperglycemia. Therefore, this study aimed to evaluate the anti-obesity efficacy of vinegar fermented using Cudrania tricuspidata fruits (CTFV) and its main phenolic constituents and to analyze its molecular mechanism and changes in obesity-related metabolizing enzymatic activities. We found that HFD significantly caused hepatic steatosis; increases in body fats, feed efficiency, liver mass, lipids, insulin, oxidative parameters, cardiovascular-associated risk indices, lipase and alpha-amylase activities, whereas CTFV efficaciously attenuated HFD-induced oxidant stress, fat accumulation, obesity-related enzymatic activity, and the activation or reduction of obesity-related molecular reactions via improving metabolic parameters including phosphorylated insulin receptor substrate 1, protein tyrosine phosphatase 1B, phosphorylated phosphoinositide 3-kinase/protein kinase B, phosphorylated mitogen-activated protein kinases, sterol regulatory element-binding protein 1c, CCAAT/enhancer-binding protein, and fatty acid synthase; and decreases in adiponectin receptor 1, leptin receptor, adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, and peroxisome proliferator-activated receptor, subsequently ameliorating HFD-induced obesity. Therefore, CTFV might provide a functional food resource or nutraceutical product for reducing body fat accumulation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Polyphenols). Q40Q9N063P (Acetic Acid). U202363UOS (Fenofibrate).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-78166-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Choi&issn=2045-2322&title=Scientific+Reports&atitle=Short-term+Cudrania+tricuspidata+fruit+vinegar+administration+attenuates+obesity+in+high-fat+diet-fed+mice+by+improving+fat+accumulation+and+metabolic+parameters.&volume=10&issue=1&spage=21102&epage=&date=2020&doi=10.1038%2Fs41598-020-78166-9&pmid=33273564&sid=OVID:medline
+
+<1071>
+Unique Identifier
+ 33263630
+Title
+ Prevalence of Sarcopenic Obesity and its Association with Functionality, Lifestyle, Biomarkers and Morbidities in Older Adults: the FIBRA-RJ Study of Frailty in Older Brazilian Adults.
+Source
+ Clinics (Sao Paulo, Brazil). 75:e1814, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Campos GC; Lourenco RA; Lopes CS
+Author NameID
+ de Campos, Glaucia Cristina; ORCID: https://orcid.org/0000-0002-1358-3503
+ Lourenco, Roberto Alves; ORCID: https://orcid.org/0000-0003-0838-1285
+ Lopes, Claudia S; ORCID: https://orcid.org/0000-0002-0401-689X
+Authors Full Name
+ de Campos, Glaucia Cristina; Lourenco, Roberto Alves; Lopes, Claudia S.
+Institution
+ de Campos, Glaucia Cristina. Departamento de Epidemiologia, Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, RJ, BR.
+ Lourenco, Roberto Alves. Departamento de Medicina Interna - Faculdade de Ciencias Medicas, Universidade do Estado do Rio de Janeiro, RJ, BR.
+ Lopes, Claudia S. Departamento de Epidemiologia, Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, RJ, BR.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers
+ Body Composition
+ Brazil/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Frailty/ep [Epidemiology]
+ *Frailty
+ Humans
+ Life Style
+ Male
+ Morbidity
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Sarcopenia/ep [Epidemiology]
+ *Sarcopenia
+Abstract
+ OBJECTIVES: To assess the prevalence of sarcopenic obesity and its association with functionality, lifestyle, biomarkers, and morbidities in older adults.
+
+ METHODS: The study analyzed cross-sectional data from 270 older adults who participated in phase III of the Frailty in Brazilian Older People Study (Fragilidade em Idosos Brasileiros-Rio de Janeiro, FIBRA-RJ study-2013). They took part in a home interview surveying socioeconomic, demographic, lifestyle, morbidities, and functional data. Blood was collected for biochemical marker analysis and participants' body composition was determined by dual-energy X-ray absorptiometry. For women, the diagnosis of sarcopenic obesity was defined at a body fat percentage >=38% and appendicular skeletal muscle mass index (ASMMI) <5.45 kg/m2. For men, a fat percentage >=27% and ASMMI <7.26 kg/m2 was defined as sarcopenic obesity. Multivariate analysis was performed using a multinomial regression model (95% confidence intervals), with sarcopenic obesity as the outcome.
+
+ RESULTS: The prevalence of sarcopenic obesity was 29.3%. In the final fitted model, the variables that displayed statistically significant association with sarcopenic obesity were lower gait speed, self-reported medical diagnosis of arthrosis or arthritis, and high levels of glycemia.
+
+ CONCLUSION: The study showed a high prevalence of sarcopenic obesity in non-institutionalized older adults in Brazil. The finding that this condition was associated with modifiable risk factors may provide insights into measures directed at prevention and reduction of the risk of sarcopenic obesity in this population subgroup.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.6061%2fclinics%2f2020%2fe1814
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Campos&issn=1807-5932&title=Clinics+%28Sao+Paulo%2C+Brazil%29&atitle=Prevalence+of+Sarcopenic+Obesity+and+its+Association+with+Functionality%2C+Lifestyle%2C+Biomarkers+and+Morbidities+in+Older+Adults%3A+the+FIBRA-RJ+Study+of+Frailty+in+Older+Brazilian+Adults.&volume=75&issue=&spage=e1814&epage=&date=2020&doi=10.6061%2Fclinics%2F2020%2Fe1814&pmid=33263630&sid=OVID:medline
+
+<1072>
+Unique Identifier
+ 33152746
+Title
+ Cross-sectional relationship among different anthropometric parameters and cardio-metabolic risk factors in a cohort of patients with overweight or obesity.
+Source
+ PLoS ONE [Electronic Resource]. 15(11):e0241841, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lampignano L; Zupo R; Donghia R; Guerra V; Castellana F; Murro I; Di Noia C; Sardone R; Giannelli G; De Pergola G
+Author NameID
+ Lampignano, Luisa; ORCID: https://orcid.org/0000-0001-9299-3211
+ Zupo, Roberta; ORCID: https://orcid.org/0000-0001-9885-1185
+ Donghia, Rossella; ORCID: https://orcid.org/0000-0002-9140-673X
+Authors Full Name
+ Lampignano, Luisa; Zupo, Roberta; Donghia, Rossella; Guerra, Vito; Castellana, Fabio; Murro, Isanna; Di Noia, Carmen; Sardone, Rodolfo; Giannelli, Gianluigi; De Pergola, Giovanni.
+Institution
+ Lampignano, Luisa. Population Health Unit-"Salus in Apulia Study" National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.
+ Zupo, Roberta. Population Health Unit-"Salus in Apulia Study" National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.
+ Donghia, Rossella. Population Health Unit-"Salus in Apulia Study" National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.
+ Guerra, Vito. Population Health Unit-"Salus in Apulia Study" National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.
+ Castellana, Fabio. Population Health Unit-"Salus in Apulia Study" National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.
+ Murro, Isanna. Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Bari, Italy.
+ Di Noia, Carmen. Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Bari, Italy.
+ Sardone, Rodolfo. Population Health Unit-"Salus in Apulia Study" National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.
+ Giannelli, Gianluigi. Scientific Direction, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.
+ De Pergola, Giovanni. Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Bari, Italy.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ Cigarette Smoking/ae [Adverse Effects]
+ Cigarette Smoking/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Italy
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Overweight/co [Complications]
+ Overweight/me [Metabolism]
+ Risk Factors
+ Snoring/co [Complications]
+ Snoring/ep [Epidemiology]
+ Waist Circumference
+ Waist-Height Ratio
+Abstract
+ BACKGROUND: Body fat distribution influences the risk of cardio-metabolic disease in people with overweight. This study was aimed at identifying the anthropometric parameters more strongly associated with the majority of cardio-metabolic risk factors.
+
+ METHODS: This study included 1214 subjects (840 women), with a body-mass-index (BMI) >= 25 Kg/m2, aged 39.2 +/- 13 years. Fasting blood glucose (FBG), triglycerides (TG), total, HDL- and LDL-cholesterol, uric acid, vitamin D, high-sensitive C-reactive protein (hs-CRP), white blood cells (WBC), platelets, insulin and insulin resistance (HOMA-IR), systolic (SBP) and diastolic blood pressure (DBP), smoking habit and snoring were evaluated as cardio-metabolic risk factors. We also included the Systematic COronary Risk Evaluation (SCORE) to estimate cardiovascular risk in our study population. BMI, waist circumference (WC), waist-to-height-ratio (WHtR) and neck circumference (NC) were evaluated as anthropometric parameters.
+
+ RESULTS: All four anthropometric parameters were positively associated to SBP, DBP, TG, FBG, insulin, HOMA-IR, WBC, and snoring (p<0.001), and negatively associated with HDL-cholesterol (p<0.001). NC showed a positive association with LDL-cholesterol (beta = 0.76; p = 0.01; 95% C.I. 0.19 to 1.32), while vitamin D was negatively associated to WC (beta = -0.16; p<0.001; 95% C.I. -0.24 to -0.09), BMI (beta = 0.42); p<0.001; 95% C.I. -0.56 to -0.28) and WHtR (beta = -24.46; p<0.001; 95% C.I. -37 to -11.9). Hs-CRP was positively correlated with WC (beta = 0.003; p = 0.003; 95% C.I. 0.001 to 0.006), BMI (beta = 0.01; p = 0.02; 95% C.I. 0.001 to 0.012) and WHtR (beta = 0.55; p = 0.01; 95% C.I. 0.14 to 0.96). SCORE was associated to NC (beta = 0.15; 95% CI 0.12 to 0.18; p<0.001), BMI (beta = -0.18; 95% CI -0.22 to 0.14; p<0.001) and WHtR (beta = 7.56; 95% CI 5.30 to 9.82; p<0.001).
+
+ CONCLUSIONS: NC, combined with BMI and WC or WHtR could represent an essential tool for use in clinical practice to define the cardio-metabolic risk in individuals with excess body weight.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0241841
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lampignano&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Cross-sectional+relationship+among+different+anthropometric+parameters+and+cardio-metabolic+risk+factors+in+a+cohort+of+patients+with+overweight+or+obesity.&volume=15&issue=11&spage=e0241841&epage=&date=2020&doi=10.1371%2Fjournal.pone.0241841&pmid=33152746&sid=OVID:medline
+
+<1073>
+Unique Identifier
+ 33135380
+Title
+ Inhibition of endoplasmic reticulum stress prevents high-fat diet mediated atrial fibrosis and fibrillation.
+Source
+ Journal of Cellular & Molecular Medicine. 24(23):13660-13668, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang Y; Yang S; Fu J; Liu A; Liu D; Cao S
+Author NameID
+ Cao, Suyan; ORCID: https://orcid.org/0000-0001-5724-6296
+Authors Full Name
+ Zhang, Yan; Yang, Shuwen; Fu, Jing; Liu, Annan; Liu, Deping; Cao, Suyan.
+Institution
+ Zhang, Yan. Department of General Practice/VIP Medical Service, Beijing Hospital, National Center of Gerontology, Beijing, China.
+ Zhang, Yan. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
+ Yang, Shuwen. Department of General Practice/VIP Medical Service, Beijing Hospital, National Center of Gerontology, Beijing, China.
+ Yang, Shuwen. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
+ Fu, Jing. Department of General Practice/VIP Medical Service, Beijing Hospital, National Center of Gerontology, Beijing, China.
+ Fu, Jing. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
+ Liu, Annan. Department of General Practice/VIP Medical Service, Beijing Hospital, National Center of Gerontology, Beijing, China.
+ Liu, Annan. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
+ Liu, Deping. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
+ Liu, Deping. Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, China.
+ Cao, Suyan. Department of General Practice/VIP Medical Service, Beijing Hospital, National Center of Gerontology, Beijing, China.
+ Cao, Suyan. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
+MeSH Subject Headings
+ Aged
+ Animals
+ Atrial Fibrillation/di [Diagnosis]
+ *Atrial Fibrillation/et [Etiology]
+ *Atrial Fibrillation/me [Metabolism]
+ Atrial Fibrillation/pc [Prevention & Control]
+ Biomarkers
+ Comorbidity
+ *Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Disease Susceptibility
+ Echocardiography
+ Endoplasmic Reticulum Chaperone BiP
+ *Endoplasmic Reticulum Stress/de [Drug Effects]
+ Female
+ Fibrosis
+ Heart Atria/de [Drug Effects]
+ *Heart Atria/pa [Pathology]
+ *Heart Atria/pp [Physiopathology]
+ Humans
+ Immunohistochemistry
+ Incidence
+ Male
+ Mice
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Overweight/co [Complications]
+ Overweight/me [Metabolism]
+Keyword Heading
+ atrial fibrillation
+ atrial fibrosis
+ endoplasmic reticulum stress
+ high-fat diet
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a significant risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia with increased mortality and morbidity. High-fat diet (HFD)-induced obesity is associated with the activation of endoplasmic reticulum stress (ERS). However, the role of ERS in HFD-induced AF remains elusive. Human atrium samples were examined for the ERS activation test. C57BL/6J mice were divided into four groups, including the control group, the HFD group, the 4-phenylbutyric acid (4-PBA) group, and the HFD + 4-PBA group. At the age of 4 weeks, the HFD group and the HFD + 4-PBA group were given HFD to construct the obesity model, while the other two groups were given a normal diet (ND). Transesophageal programmed electrical stimulation was conducted to evaluate the AF inducibility and duration. Atrial fibrosis and ERS activation were also investigated. We found that CHOP and GRP-78 protein were significantly higher in overweight patients than the controls (both P < 0.05). AF inducibility and duration of the HFD group were significantly higher than the other groups (both P < 0.05), while there was no difference between those groups (P > 0.05). The mice of the HFD group had significantly higher collagen volume fraction (CVF%) than the other groups (P < 0.05). ERS marker protein of GRP78, p-PERK, ATF6 and CHOP protein expression level was increased in the HFD group, which were significantly mitigated in the HFD + 4-PBA group. In summary, HFD-induced ERS activation facilitates atrial fibrosis and AF. The inhibition of ERS might alleviate atrial fibrosis and reduce the incidence of AF-associated obesity. Copyright © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Endoplasmic Reticulum Chaperone BiP). 0 (HSPA5 protein, human). 0 (Hspa5 protein, mouse).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fjcmm.15816
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1582-1838&title=Journal+of+Cellular+%26+Molecular+Medicine&atitle=Inhibition+of+endoplasmic+reticulum+stress+prevents+high-fat+diet+mediated+atrial+fibrosis+and+fibrillation.&volume=24&issue=23&spage=13660&epage=13668&date=2020&doi=10.1111%2Fjcmm.15816&pmid=33135380&sid=OVID:medline
+
+<1074>
+Unique Identifier
+ 33081337
+Title
+ Adherence to a Mediterranean Diet and Thyroid Function in Obesity: A Cross-Sectional Apulian Survey.
+Source
+ Nutrients. 12(10), 2020 Oct 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zupo R; Castellana F; Panza F; Lampignano L; Murro I; Di Noia C; Triggiani V; Giannelli G; Sardone R; De Pergola G
+Author NameID
+ Zupo, Roberta; ORCID: https://orcid.org/0000-0001-9885-1185
+ Castellana, Fabio; ORCID: https://orcid.org/0000-0002-6439-8228
+ Panza, Francesco; ORCID: https://orcid.org/0000-0002-7220-0656
+ Lampignano, Luisa; ORCID: https://orcid.org/0000-0001-9299-3211
+ Triggiani, Vincenzo; ORCID: https://orcid.org/0000-0001-6308-0528
+Authors Full Name
+ Zupo, Roberta; Castellana, Fabio; Panza, Francesco; Lampignano, Luisa; Murro, Isanna; Di Noia, Carmen; Triggiani, Vincenzo; Giannelli, Gianluigi; Sardone, Rodolfo; De Pergola, Giovanni.
+Institution
+ Zupo, Roberta. Population Health Unit-"Salus in Apulia Study"-National Institute of Gastroenterology-Research Hospital, IRCCS "S. De Bellis", Castellana Grotte, 70013 Bari, Italy.
+ Castellana, Fabio. Population Health Unit-"Salus in Apulia Study"-National Institute of Gastroenterology-Research Hospital, IRCCS "S. De Bellis", Castellana Grotte, 70013 Bari, Italy.
+ Panza, Francesco. Population Health Unit-"Salus in Apulia Study"-National Institute of Gastroenterology-Research Hospital, IRCCS "S. De Bellis", Castellana Grotte, 70013 Bari, Italy.
+ Panza, Francesco. Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.
+ Lampignano, Luisa. Population Health Unit-"Salus in Apulia Study"-National Institute of Gastroenterology-Research Hospital, IRCCS "S. De Bellis", Castellana Grotte, 70013 Bari, Italy.
+ Murro, Isanna. Department of Biomedical Science and Human Oncology, School of Medicine, Policlinico, University of Bari, 70124 Bari, Italy.
+ Di Noia, Carmen. Department of Biomedical Science and Human Oncology, School of Medicine, Policlinico, University of Bari, 70124 Bari, Italy.
+ Triggiani, Vincenzo. Section of Internal Medicine, Geriatrics, Endocrinology and Rare Disease, Interdisciplinary Department of Medicine, School of Medicine, University of Bari, 70124 Bari, Italy.
+ Giannelli, Gianluigi. Scientific Direction, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, 70013 Bari, Italy.
+ Sardone, Rodolfo. Population Health Unit-"Salus in Apulia Study"-National Institute of Gastroenterology-Research Hospital, IRCCS "S. De Bellis", Castellana Grotte, 70013 Bari, Italy.
+ De Pergola, Giovanni. Population Health Unit-"Salus in Apulia Study"-National Institute of Gastroenterology-Research Hospital, IRCCS "S. De Bellis", Castellana Grotte, 70013 Bari, Italy.
+ De Pergola, Giovanni. Department of Biomedical Science and Human Oncology, School of Medicine, Policlinico, University of Bari, 70124 Bari, Italy.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ *Diet, Mediterranean
+ Female
+ Humans
+ Italy
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Olive Oil
+ *Patient Compliance
+ Surveys and Questionnaires
+ *Thyroid Function Tests
+ *Thyroid Gland/pp [Physiopathology]
+ Thyrotropin/bl [Blood]
+ Thyroxine/bl [Blood]
+ Triiodothyronine/bl [Blood]
+ Vegetables
+ Young Adult
+Keyword Heading
+ Italy
+ mediterranean diet
+ obesity
+ thyroid hormones
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Much research suggests that Mediterranean eating habits and lifestyle contribute to counteract the risk of chronic diseases while promoting longevity, but little information is available on the effects of the Mediterranean diet (Med-Diet) on thyroid function, particularly among overweight/obese subjects. Nevertheless, consistent data reported a slight increase in serum levels of the thyroid-stimulating hormone (TSH) and a higher rate of conversion of thyroxine (T4) to triiodothyronine (T3) in obesity. This cross-sectional study was aimed at investigating the relationship between adherence to the Med-Diet and circulating thyroid hormones in a cohort of overweight/obese subjects from Apulia (Southern Italy). Methods: We studied 324 consecutive outpatient subjects (228 women and 96 men, age range 14-72 years) taking no drug therapy and showing normal levels of thyroid hormones, but complicated by overweight and obesity (body mass index (BMI) >= 25 Kg/m2). The PREDIMED (PREvencion con DIeta MEDiterranea) questionnaire was cross-sectionally administered to assess the adherence to the Med-Diet, and hormonal, metabolic, and routine laboratory parameters were collected. Results: Higher adherence to Med-Diet was found to be inversely related to free T3 (p < 0.01) and T4 (p < 0.01) serum levels. Considering each item in the PREDIMED questionnaire, people consuming at least four spoonfuls of extra-virgin olive oil (EVOO) per day, as well as those consuming at least two servings of vegetables per day, had lower free T3 levels (p 0.033 and p 0.021, respectively). Furthermore, consuming at least four spoonfuls of EVOO per day was found to be associated to lower free T4 serum concentrations (p 0.011). Multinomial logistic regression models, performed on tertiles of thyroid hormones to further investigate the relationship with Med-Diet, corroborated the significance only for free T4. Conclusion: Increased adherence to the Med-Diet was independently associated to a slightly reduced thyroid function, but still within the reference range for free T3 and T4 serum levels. This first finding in this field opens up a research line on any underlying biological interplay.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Olive Oil). 06LU7C9H1V (Triiodothyronine). 9002-71-5 (Thyrotropin). Q51BO43MG4 (Thyroxine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12103173
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zupo&issn=2072-6643&title=Nutrients&atitle=Adherence+to+a+Mediterranean+Diet+and+Thyroid+Function+in+Obesity%3A+A+Cross-Sectional+Apulian+Survey.&volume=12&issue=10&spage=&epage=&date=2020&doi=10.3390%2Fnu12103173&pmid=33081337&sid=OVID:medline
+
+<1075>
+Unique Identifier
+ 33117281
+Title
+ Higher Muscle Mass Implies Increased Free-Thyroxine to Free-Triiodothyronine Ratio in Subjects With Overweight and Obesity.
+Source
+ Frontiers in Endocrinology. 11:565065, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zupo R; Castellana F; Sardone R; Lampignano L; Paradiso S; Giagulli VA; Triggiani V; Di Lorenzo L; Giannelli G; De Pergola G
+Authors Full Name
+ Zupo, Roberta; Castellana, Fabio; Sardone, Rodolfo; Lampignano, Luisa; Paradiso, Silvia; Giagulli, Vito Angelo; Triggiani, Vincenzo; Di Lorenzo, Luigi; Giannelli, Gianluigi; De Pergola, Giovanni.
+Institution
+ Zupo, Roberta. Population Health Unit - "Salus in Apulia Study", National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Bari, Italy.
+ Castellana, Fabio. Population Health Unit - "Salus in Apulia Study", National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Bari, Italy.
+ Sardone, Rodolfo. Population Health Unit - "Salus in Apulia Study", National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Bari, Italy.
+ Lampignano, Luisa. Population Health Unit - "Salus in Apulia Study", National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Bari, Italy.
+ Paradiso, Silvia. Clinical Nutrition Unit, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Bari, Italy.
+ Giagulli, Vito Angelo. Section of Internal Medicine, Geriatrics, Endocrinology and Rare Disease, Interdisciplinary Department of Medicine, School of Medicine, University of Bari, Bari, Italy.
+ Triggiani, Vincenzo. Section of Internal Medicine, Geriatrics, Endocrinology and Rare Disease, Interdisciplinary Department of Medicine, School of Medicine, University of Bari, Bari, Italy.
+ Di Lorenzo, Luigi. Dipartimento di Medicina Interna e Medicina Pubblica, Sezione di Medicina del Lavoro "E.C. Vigliani", University of Bari, Policlinico, Bari, Italy.
+ Giannelli, Gianluigi. Scientific Direction, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Bari, Italy.
+ De Pergola, Giovanni. Population Health Unit - "Salus in Apulia Study", National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Bari, Italy.
+ De Pergola, Giovanni. Clinical Nutrition Unit, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Bari, Italy.
+MeSH Subject Headings
+ Adult
+ Anthropometry/mt [Methods]
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Electric Impedance
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Muscle Strength/ph [Physiology]
+ *Muscle, Skeletal/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Overweight/bl [Blood]
+ Overweight/di [Diagnosis]
+ *Thyroxine/bl [Blood]
+ *Triiodothyronine/bl [Blood]
+Keyword Heading
+ Italy
+ body composition
+ obesity
+ skeletal muscle mass
+ thyroid hormone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Thyroid hormones control both metabolic pathways and body composition, whereas little knowledge is available about the possible influence of skeletal muscle mass (MM) on thyroid hormone metabolism and circulating levels. This was a cross-sectional study conducted at the Population Health Unit of the National Institute of Gastroenterology IRCCS "S. de Bellis" (Italy) and investigating the extent to which skeletal MM affects thyroid function in obesity. Two hundred twenty-seven consecutive healthy volunteers (155 women and 72 men) with overweight and obesity (BMI >= 25 kg/m2) and taking no medication or supplement were assessed for hormone, metabolic and routine laboratory parameters. Body composition parameters were collected by using bioelectrical impedance analysis (BIA). MM was directly related to the body mass index (BMI), waist circumference (WC), insulin, triglycerides, uric acid and free-triiodothyronine (FT3) serum levels, FT3 to the free-thyroxine (FT4) ratio, and insulin-resistance (HOMA-IR), and inversely related to age, total, and HDL-cholesterol serum levels. Multiple regression models confirmed the relationship between MM and the FT3 to FT4 ratio, independently of age, BMI, TSH, triglycerides, and insulin serum levels. The same analyses run by gender showed that this relationship maintained significance only in men. Increased skeletal MM in obesity results in improved thyroid activity mediated by increased T4 conversion to T3, and higher FT3 circulating levels, particularly in men. In conclusion, preserving a greater skeletal MM in obesity helps to enhance thyroid activity.
+
+ Clinical Trial Registration: ClinicalTrials.gov, identifier NCT04327375. Copyright © 2020 Zupo, Castellana, Sardone, Lampignano, Paradiso, Giagulli, Triggiani, Di Lorenzo, Giannelli and De Pergola.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 06LU7C9H1V (Triiodothyronine). Q51BO43MG4 (Thyroxine).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffendo.2020.565065
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zupo&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Higher+Muscle+Mass+Implies+Increased+Free-Thyroxine+to+Free-Triiodothyronine+Ratio+in+Subjects+With+Overweight+and+Obesity.&volume=11&issue=&spage=565065&epage=&date=2020&doi=10.3389%2Ffendo.2020.565065&pmid=33117281&sid=OVID:medline
+
+<1076>
+Unique Identifier
+ 33028190
+Title
+ DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia.
+Source
+ Molecular Medicine. 26(1):93, 2020 10 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Platek T; Polus A; Goralska J; Razny U; Gruca A; Kiec-Wilk B; Zabielski P; Kapusta M; Slowinska-Solnica K; Solnica B; Malczewska-Malec M; Dembinska-Kiec A
+Author NameID
+ Platek, Teresa; ORCID: https://orcid.org/0000-0003-1935-1866
+Authors Full Name
+ Platek, Teresa; Polus, Anna; Goralska, Joanna; Razny, Urszula; Gruca, Anna; Kiec-Wilk, Beata; Zabielski, Piotr; Kapusta, Maria; Slowinska-Solnica, Krystyna; Solnica, Bogdan; Malczewska-Malec, Malgorzata; Dembinska-Kiec, Aldona.
+Institution
+ Platek, Teresa. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland. teresa.staszel@cm-uj.krakow.pl.
+ Polus, Anna. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Goralska, Joanna. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Razny, Urszula. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Gruca, Anna. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Kiec-Wilk, Beata. Department of Metabolic Diseases, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Kiec-Wilk, Beata. Department of Metabolic Diseases, University Hospital in Krakow, Jakubowskiego 2, 30-688, Krakow, Poland.
+ Zabielski, Piotr. Department of Physiology, Medical University of Bialystok, Mickiewicza 2C, 15-222, Bialystok, Poland.
+ Kapusta, Maria. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Slowinska-Solnica, Krystyna. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Solnica, Bogdan. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Malczewska-Malec, Malgorzata. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+ Dembinska-Kiec, Aldona. Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Krakow, Poland.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers
+ Body Weights and Measures
+ CpG Islands
+ *DNA Methylation
+ Disease Susceptibility
+ *Epigenesis, Genetic
+ Epigenomics/mt [Methods]
+ *Epigenomics
+ Female
+ Gene Expression Regulation
+ Gene Regulatory Networks
+ Humans
+ Hypercholesterolemia/bl [Blood]
+ *Hypercholesterolemia/et [Etiology]
+ Hypercholesterolemia/me [Metabolism]
+ *Lipid Metabolism/ge [Genetics]
+ Lipids/bl [Blood]
+ Male
+ Metabolic Networks and Pathways
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+Keyword Heading
+ DNA methylation
+ Hypercholesterolemia
+ Obesity
+ Plasma lipids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Epigenetics can contribute to lipid disorders in obesity. The DNA methylation pattern can be the cause or consequence of high blood lipids. The aim of the study was to investigate the DNA methylation profile in peripheral leukocytes associated with elevated LDL-cholesterol level in overweight and obese individuals.
+
+ METHODS: To identify the differentially methylated genes, genome-wide DNA methylation microarray analysis was performed in leukocytes of obese individuals with high LDL-cholesterol (LDL-CH, >= 3.4 mmol/L) versus control obese individuals with LDL-CH, < 3.4 mmol/L. Biochemical tests such as serum glucose, total cholesterol, HDL cholesterol, triglycerides, insulin, leptin, adiponectin, FGF19, FGF21, GIP and total plasma fatty acids content have been determined. Oral glucose and lipid tolerance tests were also performed. Human DNA Methylation Microarray (from Agilent Technologies) containing 27,627 probes for CpG islands was used for screening of DNA methylation status in 10 selected samples. Unpaired t-test and Mann-Whitney U-test were used for biochemical and anthropometric parameters statistics. For microarrays analysis, fold of change was calculated comparing hypercholesterolemic vs control group. The q-value threshold was calculated using moderated Student's t-test followed by Benjamini-Hochberg multiple test correction FDR.
+
+ RESULTS: In this preliminary study we identified 190 lipid related CpG loci differentially methylated in hypercholesterolemic versus control individuals. Analysis of DNA methylation profiles revealed several loci engaged in plasma lipoprotein formation and metabolism, cholesterol efflux and reverse transport, triglycerides degradation and fatty acids transport and beta-oxidation. Hypermethylation of CpG loci located in promoters of genes regulating cholesterol metabolism: PCSK9, LRP1, ABCG1, ANGPTL4, SREBF1 and NR1H2 in hypercholesterolemic patients has been found. Novel epigenetically regulated CpG sites include ABCG4, ANGPTL4, AP2A2, AP2M1, AP2S1, CLTC, FGF19, FGF1R, HDLBP, LIPA, LMF1, LRP5, LSR, NR1H2 and ZDHHC8 genes.
+
+ CONCLUSIONS: Our results indicate that obese individuals with hypercholesterolemia present specific DNA methylation profile in genes related to lipids transport and metabolism. Detailed knowledge of epigenetic regulation of genes, important for lipid disorders in obesity, underlies the possibility to influence target genes by changing diet and lifestyle, as DNA methylation is reversible and depends on environmental factors. These findings give rise for further studies on factors that targets methylation of revealed genes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs10020-020-00220-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Platek&issn=1076-1551&title=Molecular+Medicine&atitle=DNA+methylation+microarrays+identify+epigenetically+regulated+lipid+related+genes+in+obese+patients+with+hypercholesterolemia.&volume=26&issue=1&spage=93&epage=&date=2020&doi=10.1186%2Fs10020-020-00220-z&pmid=33028190&sid=OVID:medline
+
+<1077>
+Unique Identifier
+ 32751185
+Title
+ Impaired CPT1A Gene Expression Response to Retinoic Acid Treatment in Human PBMC as Predictor of Metabolic Risk.
+Source
+ Nutrients. 12(8), 2020 Jul 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cifre M; Palou A; Oliver P
+Author NameID
+ Palou, Andreu; ORCID: https://orcid.org/0000-0002-0295-4452
+ Oliver, Paula; ORCID: https://orcid.org/0000-0002-7821-8806
+Authors Full Name
+ Cifre, Margalida; Palou, Andreu; Oliver, Paula.
+Institution
+ Cifre, Margalida. Nutrigenomics and Obesity Group, University of the Balearic Islands, 07122 Palma, Spain.
+ Cifre, Margalida. CIBER of Pathophysiology of Obesity and Nutrition (CIBEROBN), 28029 Madrid, Spain.
+ Palou, Andreu. Nutrigenomics and Obesity Group, University of the Balearic Islands, 07122 Palma, Spain.
+ Palou, Andreu. CIBER of Pathophysiology of Obesity and Nutrition (CIBEROBN), 28029 Madrid, Spain.
+ Palou, Andreu. Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain.
+ Oliver, Paula. Nutrigenomics and Obesity Group, University of the Balearic Islands, 07122 Palma, Spain.
+ Oliver, Paula. CIBER of Pathophysiology of Obesity and Nutrition (CIBEROBN), 28029 Madrid, Spain.
+ Oliver, Paula. Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cardiometabolic Risk Factors
+ *Carnitine O-Palmitoyltransferase/de [Drug Effects]
+ Cholesterol, HDL/bl [Blood]
+ *Gene Expression/de [Drug Effects]
+ Healthy Volunteers
+ Humans
+ *Leukocytes, Mononuclear/me [Metabolism]
+ Lipid Metabolism/de [Drug Effects]
+ Male
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/ge [Genetics]
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Overweight/bl [Blood]
+ *Overweight/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+ Real-Time Polymerase Chain Reaction
+ *Tretinoin/pd [Pharmacology]
+Keyword Heading
+ HDL-cholesterol
+ biomarkers
+ blood cells
+ obesity
+ retinoic acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Ex vivo human peripheral blood mononuclear cell (PBMC) systems offer the possibility to test transcriptomic effects of food bioactive compounds with potential health effects. We investigated all-trans retinoic acid (ATRA) effect on mRNA expression of key lipid metabolism and inflammatory genes in PBMCs from normal-weight (NW) and overweight-obese (OW-OB) men with different metabolic syndrome-related features. PBMCs were incubated with 10 microM ATRA and mRNA levels of selected genes were analyzed using real-time RT-qPCR. Human ex vivo PBMCs responded to ATRA treatment, but the response for some genes was dependent on body mass index (BMI), with a lower response in PBMC from OW-OB than from NW donors. Moreover, gene expression response was affected by circulating high-density lipoprotein (HDL)-cholesterol levels. Particularly, the response to ATRA of CPT1A, previously reported as a sensitive metabolic risk predictive biomarker, was dependent on HDL levels and not on BMI, being impaired in those individuals with lower HDL levels, specifically in OW-OB. Thus, PBMCs' insensitivity to ATRA, which can be considered as indicative of impaired metabolism, was observed in individuals with higher metabolic risk (OW-OB with low HDL levels). In conclusion, an ex vivo human PBMC system indicates that ATRA response could be influenced by metabolic syndrome features. Moreover, our study reinforces the role of CPT1A as a marker of metabolic risk and points to plasmatic HDL-cholesterol levels as a parameter to take into consideration when the effects of nutritional factors and/or dietary interventions on humans are under study. Further studies including women are required to detect potential gender differences in the observed effects.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (RNA, Messenger). 5688UTC01R (Tretinoin). EC 2-3-1-21 (CPT1A protein, human). EC 2-3-1-21 (Carnitine O-Palmitoyltransferase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12082269
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cifre&issn=2072-6643&title=Nutrients&atitle=Impaired+CPT1A+Gene+Expression+Response+to+Retinoic+Acid+Treatment+in+Human+PBMC+as+Predictor+of+Metabolic+Risk.&volume=12&issue=8&spage=&epage=&date=2020&doi=10.3390%2Fnu12082269&pmid=32751185&sid=OVID:medline
+
+<1078>
+Unique Identifier
+ 32605552
+Title
+ The study protocol for a pseudo-randomised pre-post designed controlled intervention trial to study the effects of a 7-week cooking program on self-efficacy and biomarkers of health: the ECU lifestyle and biomarkers get connected study (ECULABJMOF) including the Jamie's Ministry of Food WA participant experience.
+Source
+ BMC Public Health. 20(1):1037, 2020 Jun 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rees J; Christophersen CC; Lewis JR; Lo J; Sambell R; Costello L; Walker C; Byrne MF; Boyce MC; Newton RU; Devine A
+Author NameID
+ Rees, Joanna; ORCID: http://orcid.org/0000-0002-9165-5189
+Authors Full Name
+ Rees, Joanna; Christophersen, Claus C; Lewis, Joshua R; Lo, Johnny; Sambell, Ros; Costello, Leesa; Walker, Cailyn; Byrne, Matt F; Boyce, Mary C; Newton, Robert U; Devine, Amanda.
+Institution
+ Rees, Joanna. School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia. j.rees@ecu.edu.au.
+ Christophersen, Claus C. School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
+ Christophersen, Claus C. WA Human Microbiome Collaboration Centre, School of Molecular & Life Sciences, Curtin University, Perth, WA, Australia.
+ Lewis, Joshua R. School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
+ Lewis, Joshua R. Medical School, University of Western Australia, Perth, Australia.
+ Lewis, Joshua R. School of Public Health, University of Sydney, Sydney, Australia.
+ Lo, Johnny. School of Science, Edith Cowan University, Perth, WA, Australia.
+ Sambell, Ros. School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
+ Costello, Leesa. School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
+ Walker, Cailyn. School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
+ Byrne, Matt F. School of Education, Edith Cowan University, Perth, WA, Australia.
+ Boyce, Mary C. School of Science, Edith Cowan University, Perth, WA, Australia.
+ Boyce, Mary C. Centre for Integrated Metabolomics and Computational Biology, Edith Cowan University, Perth, WA, Australia.
+ Newton, Robert U. School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
+ Newton, Robert U. Exercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
+ Newton, Robert U. School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, QLD, Australia.
+ Devine, Amanda. School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
+MeSH Subject Headings
+ Adult
+ Australia
+ Biomarkers
+ Chronic Disease
+ *Cooking
+ Diet/ae [Adverse Effects]
+ Diet/sn [Statistics & Numerical Data]
+ Female
+ *Health Knowledge, Attitudes, Practice
+ *Health Promotion/mt [Methods]
+ Humans
+ Life Style
+ Male
+ Obesity/ep [Epidemiology]
+ Obesity/pc [Prevention & Control]
+ Personal Satisfaction
+ Program Evaluation
+ Research Design
+ *Self Efficacy
+ Surveys and Questionnaires
+ Western Australia/ep [Epidemiology]
+Keyword Heading
+ Cooking program
+ Dietary intake
+ Mental health
+ Microbiota
+ Self-efficacy
+ Study protocol
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Australia, like other nations, has experienced a shift in dietary patterns away from home cooking of nutritious foods, towards a reliance on pre-prepared convenience meals. These are typically energy-dense, nutrient-poor and contribute to the rising prevalence of obesity and chronic disease burden. The aims of this study were to evaluate whether a community-based cooking program instigated a change to participants' skills, attitudes, knowledge, enjoyment and satisfaction of cooking and cooking confidence (self-efficacy).
+
+ METHODS: The pseudo-random, pre-post study design consisted of an intervention and a control group. Participant recruitment and group allocation was based on their program start dates. Intervention participants were surveyed three times (baseline, 7 weeks and 6 months) and the control group were surveyed at baseline and 5 weeks. All participants were registered via an online website and were 18 years or over. Upon consent, participants were offered four levels of commitment, defined by different assessments. The minimum participation level included an online survey and levels 2, 3 and 4 involved attendance at a clinic with increasing functional, anthropometric and biomarker measurements. Primary endpoints were participants' cooking confidence as a proxy for self-efficacy. Secondary endpoints were dietary intake, physical activity levels, body composition, anthropometry, blood, urine and faecal biomarkers of systemic, physical and mental health.
+
+ DISCUSSION: The community cooking program provided participants with information and advice on food sourcing, preparation and nutrition to improve home cooking skills. The study was designed to explore whether food literacy programs are efficacious in improving participant physical health and well-being in order to combat the rise in obesity and diet-related disease. It will support future use of public health cooking program initiatives aimed at improving food literacy, self-efficacy and physical and mental health. The extensive data collected will inform future research into the relationship between diet, the gut-microbiota and human health.
+
+ TRIAL REGISTRATION: Retrospectively registered on 16.08.2019 with the Australian New Zealand Clinical Trials Registry (ANZCTR). ACTRN12619001144101 . Protocol version 4.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12889-020-09124-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rees&issn=1471-2458&title=BMC+Public+Health&atitle=The+study+protocol+for+a+pseudo-randomised+pre-post+designed+controlled+intervention+trial+to+study+the+effects+of+a+7-week+cooking+program+on+self-efficacy+and+biomarkers+of+health%3A+the+ECU+lifestyle+and+biomarkers+get+connected+study+%28ECULABJMOF%29+including+the+Jamie%27s+Ministry+of+Food+WA+participant+experience.&volume=20&issue=1&spage=1037&epage=&date=2020&doi=10.1186%2Fs12889-020-09124-3&pmid=32605552&sid=OVID:medline
+
+<1079>
+Unique Identifier
+ 31148390
+Title
+ What is the best biological parameter to predict erectile dysfunction in men aged >55 years with type 2 diabetes?.
+Source
+ Journal of Diabetes Investigation. 11(1):170-173, 2020 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Raharinavalona SA; Chevalier N; Gruel C; N'toutoum AC; Velayoudom Cephise FL
+Author NameID
+ Velayoudom Cephise, Fritz-Line; ORCID: https://orcid.org/0000-0003-4623-3777
+Authors Full Name
+ Raharinavalona, Sitraka A; Chevalier, Nicolas; Gruel, Claude; N'toutoum, Andre-Christian; Velayoudom Cephise, Fritz-Line.
+Institution
+ Raharinavalona, Sitraka A. Department of Endocrinology and Diabetology, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France.
+ Chevalier, Nicolas. Department of Endocrinology, Diabetology, Reproduction, Hopital de l'Archet, Centre Hospitalier Universitaire de Nice, Universite Cote d'Azur, Inserm UMR U1065/UNS, Nice, France.
+ Gruel, Claude. Department of Endocrinology and Diabetology, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France.
+ N'toutoum, Andre-Christian. Department of Endocrinology and Diabetology, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France.
+ Velayoudom Cephise, Fritz-Line. Department of Endocrinology and Diabetology, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France.
+ Velayoudom Cephise, Fritz-Line. L.A.M.I.A EA-4540, University of Antilles, Guadeloupe, France.
+MeSH Subject Headings
+ *Biomarkers/an [Analysis]
+ *Body Mass Index
+ Case-Control Studies
+ Cross-Sectional Studies
+ Erectile Dysfunction/bl [Blood]
+ *Erectile Dysfunction/di [Diagnosis]
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Surveys and Questionnaires
+ *Testosterone/bl [Blood]
+Keyword Heading
+ Bioavailable testosterone
+ Erectile dysfunction
+ Total testosterone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ To date, there is no evidence regarding the best biological marker to predict erectile dysfunction (ED) in men aged >55 years with type 2 diabetes. This prospective study included data from men aged >55 years with type 2 diabetes. ED was assessed by the International Index of Erectile Function 15-item survey. Total testosterone (TT) levels and bioavailable testosterone were measured; the free testosterone index was calculated. Data from 155 men (aged 64 +/- 7 years) were explored. The prevalence of ED and testosterone deficiency was 78.7% and 34.8%, respectively. After univariate analysis, TT and bioavailable testosterone were associated with ED (P = 0.01). After multivariate analysis, and adjustment for age, body mass index, tobacco, alcohol, duration of diabetes, TT, bioavailable testosterone, vitamin D and high-sensitivity C-reactive protein, we found that only high-sensitivity C-reactive protein was significantly predictive of ED. TT could predict ED, but it lacks specificity. We found a potential role of high-sensitivity C-reactive protein as a predictive marker of ED in this targeted population. Copyright © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3XMK78S47O (Testosterone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fjdi.13089
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Raharinavalona&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=What+is+the+best+biological+parameter+to+predict+erectile+dysfunction+in+men+aged+%3E55+years+with+type+2+diabetes%3F.&volume=11&issue=1&spage=170&epage=173&date=2020&doi=10.1111%2Fjdi.13089&pmid=31148390&sid=OVID:medline
+
+<1080>
+Unique Identifier
+ 31069995
+Title
+ Longitudinal examination of pancreatic beta-cell function in Japanese individuals.
+Source
+ Journal of Diabetes Investigation. 11(1):70-74, 2020 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fujikawa R; Ito C; Kira S; Misumi M
+Author NameID
+ Fujikawa, Rumi; ORCID: https://orcid.org/0000-0003-3275-1303
+ Kira, Sakurako; ORCID: https://orcid.org/0000-0001-5999-8459
+Authors Full Name
+ Fujikawa, Rumi; Ito, Chikako; Kira, Sakurako; Misumi, Munechika.
+Institution
+ Fujikawa, Rumi. Grand Tower Medical Court, Hiroshima, Japan.
+ Ito, Chikako. Grand Tower Medical Court, Hiroshima, Japan.
+ Kira, Sakurako. Grand Tower Medical Court, Hiroshima, Japan.
+ Kira, Sakurako. Health Management Center, Hiroshima Atomic Bomb Causality Council, Hiroshima, Japan.
+ Misumi, Munechika. Faculty of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
+MeSH Subject Headings
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Glucose Tolerance Test
+ *Glycated Hemoglobin/an [Analysis]
+ Humans
+ Incidence
+ *Insulin-Secreting Cells/pa [Pathology]
+ Japan/ep [Epidemiology]
+ Longitudinal Studies
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Retrospective Studies
+Keyword Heading
+ Obesity
+ Oral glucose tolerance test
+ beta-Cell function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: We carried out a retrospective, longitudinal analysis of beta-cell function between a diabetes mellitus group, including those that progressed to diabetes mellitus during the follow-up period, and a diabetic type with glycated hemoglobin (HbA1c) <6.5 group, including those that progressed to a diabetic type during the follow-up period. beta-Cell function was assessed using homeostasis model of assessment of beta-cell function.
+
+ MATERIALS AND METHODS: The relationship between the duration of diabetes mellitus or the diabetic type and pancreatic beta-cell function was compared between the diabetes mellitus group (1,817) and diabetic type with HbA1c <6.5 group (1,843) using results from an oral glucose tolerance test. Linear mixed effects models were used to analyze repeated measurements of oral glucose tolerance tests.
+
+ RESULTS: The slope of the regression line of beta-cell function for the duration of the diabetes mellitus group was -2.2%/year before the diagnosis. The slope differed after the diagnosis, and the difference was 1.3. The slope of the diabetic type group was -1.2%/year, and no significant difference was observed in the slope before and after the diagnosis. beta-Cell function at the onset was 54.3% in the diabetic type group and 40.6% in the diabetes mellitus group, and the slope of the regression line was significantly higher in the diabetes mellitus group. We divided the diabetes mellitus and diabetic type with HbA1c <6.5 groups into obese and non-obese participants. beta-Cell function declined more with obesity.
+
+ CONCLUSIONS: Subsequent declines in beta-cell function were faster in the diabetes mellitus group than that in the diabetic type with HbA1c <6.5 group, and increased with obesity. Copyright © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fjdi.13068
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fujikawa&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Longitudinal+examination+of+pancreatic+beta-cell+function+in+Japanese+individuals.&volume=11&issue=1&spage=70&epage=74&date=2020&doi=10.1111%2Fjdi.13068&pmid=31069995&sid=OVID:medline
+
+<1081>
+Unique Identifier
+ 33058956
+Title
+ Obesity markers for the prediction of incident type 2 diabetes mellitus in resource-poor settings: The CRONICAS Cohort Study.
+Source
+ Diabetes Research & Clinical Practice. 170:108494, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zafra-Tanaka JH; Miranda JJ; Gilman RH; Checkley W; Smeeth L; Bernabe-Ortiz A
+Authors Full Name
+ Zafra-Tanaka, Jessica Hanae; Miranda, J Jaime; Gilman, Robert H; Checkley, William; Smeeth, Liam; Bernabe-Ortiz, Antonio.
+Institution
+ Zafra-Tanaka, Jessica Hanae. CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru. Electronic address: j.zafra.t@gmail.com.
+ Miranda, J Jaime. CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; School of Medicine, Cayetano Heredia University, Lima, Peru.
+ Gilman, Robert H. CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; Program in Global Disease Epidemiology and Control, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.
+ Checkley, William. CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
+ Smeeth, Liam. CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
+ Bernabe-Ortiz, Antonio. CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Cohort Studies
+ *Diabetes Mellitus, Type 2/co [Complications]
+ *Electric Impedance/tu [Therapeutic Use]
+ Female
+ Humans
+ Incidence
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Peru
+ Waist Circumference
+ Waist-Height Ratio
+ Waist-Hip Ratio
+Keyword Heading
+ Adiposity
+ Bioelectrical impedance
+ Diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: To determine the predictive performance of well-known obesity markers: body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), waist-height ratio (WHtR), and total body fat percentage (TBF%), to identify incident cases of type 2 diabetes mellitus T2DM.
+
+ METHODS: Secondary data analysis of the CRONICAS Cohort Study, conducted in 3 regions of Peru. Participants without T2DM at baseline were selected for analyses. The obesity markers were evaluated at the beginning of the study, and the development of T2DM was determined at 30 months of follow-up. The predictive performance of the markers was calculated using areas under the curve (AUC), and sensitivity and specificity of the best cutoff points were estimated.
+
+ RESULTS: A total of 2510 participants with no diabetes at baseline, median age 54.1 years (inter-quartile range: 44.6 to 63.5), were included in the analysis. The cumulative incidence of T2DM at 30 months of follow-up was 4.7%. All the AUC studied for obesity markers and TBF% were poor.
+
+ CONCLUSIONS: We found that obesity markers had a poor predictive performance (AUC) for the incidence of T2DM when used alone. The BMI, WC and WHtR had better performance for the incidence of T2DM relative to the WHR among women, and no differences in performance between obesity markers were found among men. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.diabres.2020.108494
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zafra-Tanaka&issn=0168-8227&title=Diabetes+Research+%26+Clinical+Practice&atitle=Obesity+markers+for+the+prediction+of+incident+type+2+diabetes+mellitus+in+resource-poor+settings%3A+The+CRONICAS+Cohort+Study.&volume=170&issue=&spage=108494&epage=&date=2020&doi=10.1016%2Fj.diabres.2020.108494&pmid=33058956&sid=OVID:medline
+
+<1082>
+Unique Identifier
+ 32581074
+Title
+ Secretion of Recombinant Interleukin-22 by Engineered Lactobacillus reuteri Reduces Fatty Liver Disease in a Mouse Model of Diet-Induced Obesity.
+Source
+ Msphere. 5(3), 2020 06 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Oh JH; Schueler KL; Stapleton DS; Alexander LM; Yen CE; Keller MP; Attie AD; van Pijkeren JP
+Author NameID
+ Oh, Jee-Hwan; ORCID: https://orcid.org/0000-0001-9033-8539
+ van Pijkeren, Jan-Peter; ORCID: https://orcid.org/0000-0003-4649-5726
+Authors Full Name
+ Oh, Jee-Hwan; Schueler, Kathryn L; Stapleton, Donnie S; Alexander, Laura M; Yen, Chi-Liang Eric; Keller, Mark P; Attie, Alan D; van Pijkeren, Jan-Peter.
+Institution
+ Oh, Jee-Hwan. Department of Food Science, University of Wisconsin-Madison, Madison, Wisconsin, USA.
+ Schueler, Kathryn L. Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
+ Stapleton, Donnie S. Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
+ Alexander, Laura M. Department of Food Science, University of Wisconsin-Madison, Madison, Wisconsin, USA.
+ Yen, Chi-Liang Eric. Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
+ Keller, Mark P. Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
+ Attie, Alan D. Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
+ van Pijkeren, Jan-Peter. Department of Food Science, University of Wisconsin-Madison, Madison, Wisconsin, USA vanpijkeren@wisc.edu.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Diet
+ Disease Models, Animal
+ *Fatty Liver/pc [Prevention & Control]
+ *Interleukins/ad [Administration & Dosage]
+ Interleukins/ge [Genetics]
+ *Limosilactobacillus reuteri/ge [Genetics]
+ Male
+ Metabolic Syndrome/th [Therapy]
+ Mice
+ Mice, Inbred C57BL
+ Obesity/et [Etiology]
+ *Obesity/th [Therapy]
+ *Probiotics/tu [Therapeutic Use]
+ Recombinant Proteins/ad [Administration & Dosage]
+ Recombinant Proteins/ge [Genetics]
+ Interleukin-22
+Keyword Heading
+ IL-22
+ Lactobacillus reuteri
+ diet-induced metabolic syndrome
+ engineered probiotic
+ fatty liver disease
+ interleukin-22
+ nonalcoholic fatty liver disease
+ probiotic
+ steatosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The incidence of metabolic syndrome continues to rise globally. In mice, intravenous administration of interleukin-22 (IL-22) ameliorates various disease phenotypes associated with diet-induced metabolic syndrome. In patients, oral treatment is favored over intravenous treatment, but methodologies to deliver IL-22 via the oral route are nonexistent. The goal of this study was to assess to what extent engineered Lactobacillus reuteri secreting IL-22 could ameliorate nonalcoholic fatty liver disease. We used a mouse model of diet-induced obesity and assessed various markers of metabolic syndrome following treatment with L. reuteri and a recombinant derivative. Mice that received an 8-week treatment of wild-type probiotic gained less weight and had a smaller fat pad than the control group, but these phenotypes were not further enhanced by recombinant L. reuteri However, L. reuteri secreting IL-22 significantly reduced liver weight and triglycerides at levels that exceeded those of the probiotic wild-type treatment group. Our findings are interesting in light of the observed phenotypes associated with reduced nonalcoholic liver disease, in humans the most prevalent chronic liver disease, following treatment of a next-generation probiotic that is administered orally. Once biological and environmental containment strategies are in place, therapeutic applications of recombinant Lactobacillus reuteri are on the horizon. IMPORTANCE In humans, nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease due to the increased prevalence of obesity. While treatment of NAFLD is often geared toward lifestyle changes, such as diet and exercise, the use of dietary supplements such as probiotics is underinvestigated. Here, we report that probiotic Lactobacillus reuteri reduces fatty liver in a mouse model of diet-induced obesity. This phenotype was further enhanced upon delivery of recombinant interleukin-22 by engineered Lactobacillus reuteri These observations pave the road to a better understanding of probiotic mechanisms driving the reduction of diet-induced steatosis and to development of next-generation probiotics for use in the clinic. Ultimately, these studies may lead to rational selection of (engineered) probiotics to ameliorate fatty liver disease. Copyright © 2020 Oh et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukins). 0 (Recombinant Proteins).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1128%2fmSphere.00183-20
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Oh&issn=2379-5042&title=Msphere&atitle=Secretion+of+Recombinant+Interleukin-22+by+Engineered+Lactobacillus+reuteri+Reduces+Fatty+Liver+Disease+in+a+Mouse+Model+of+Diet-Induced+Obesity.&volume=5&issue=3&spage=&epage=&date=2020&doi=10.1128%2FmSphere.00183-20&pmid=32581074&sid=OVID:medline
+
+<1083>
+Unique Identifier
+ 32422228
+Title
+ Uncarboxylated matrix Gla-protein: A biomarker of vitamin K status and cardiovascular risk.
+Source
+ Clinical Biochemistry. 83:49-56, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jespersen T; Mollehave LT; Thuesen BH; Skaaby T; Rossing P; Toft U; Jorgensen NR; Corfixen BL; Jakobsen J; Frimodt-Moller M; Linneberg A
+Authors Full Name
+ Jespersen, T; Mollehave, L T; Thuesen, B H; Skaaby, T; Rossing, P; Toft, U; Jorgensen, N R; Corfixen, B L; Jakobsen, J; Frimodt-Moller, M; Linneberg, A.
+Institution
+ Jespersen, T. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Capital Region, Denmark. Electronic address: torkil.jespersen.01@regionh.dk.
+ Mollehave, L T. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Capital Region, Denmark.
+ Thuesen, B H. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Capital Region, Denmark.
+ Skaaby, T. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Capital Region, Denmark.
+ Rossing, P. Steno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
+ Toft, U. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Capital Region, Denmark.
+ Jorgensen, N R. Department of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark; OPEN, Odense Patient Data Explorative Network, Odense University Hospital/Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
+ Corfixen, B L. Department of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark.
+ Jakobsen, J. National Food Institute, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.
+ Frimodt-Moller, M. Steno Diabetes Center Copenhagen, Gentofte, Denmark.
+ Linneberg, A. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Capital Region, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ *Calcium-Binding Proteins/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ Denmark/ep [Epidemiology]
+ *Extracellular Matrix Proteins/bl [Blood]
+ Female
+ Heart Disease Risk Factors
+ Humans
+ Male
+ Middle Aged
+ Obesity
+ Odds Ratio
+ Vascular Calcification/bl [Blood]
+ *Vitamin K Deficiency/bl [Blood]
+ Vitamin K Deficiency/co [Complications]
+ Young Adult
+ Matrix Gla Protein
+Keyword Heading
+ Cardiovascular risk
+ Matrix Gla protein
+ Vitamin K
+ dp-ucMGP
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Dephosphorylated uncarboxylated matrix Gla-protein (dp-ucMGP) is a biomarker of functional vitamin K status. High plasma dp-ucMGP concentrations reflect a low vitamin K status and have been related to vascular calcification. Our aims were to assess plasma levels of dp-ucMGP and their association with cardiovascular risk in a general population.
+
+ METHODS: Plasma dp-ucMGP measurements were performed using the IDS-iSYS InaKtif MGP assay in 491 consecutive participants in a Danish general population study (229 males and 262 females, aged 19-71 years). Multivariable linear and logistic regressions were used to assess the association between dp-ucMGP levels and cardiovascular risk factors.
+
+ RESULTS: Mean +/- standard deviation (SD) for dp-ucMGP was 465 +/- 181 pmol/L, and upper 95th percentile was 690 pmol/L. In logistic regression analyses, an increase in dp-ucMGP category (<300, 300-399, 400-499, >=500 pmol/L) was positively associated with obesity, odds ratio (OR) 2.27 (95% confidence interval (CI) 1.54-3.33), history of cardiovascular disease, OR 1.77 (CI 1.02-3.05), and above-median estimated pulse wave velocity (ePWV), OR 1.54 (CI 1.21-1.96), when adjusted for age, sex, and lifestyle factors. 1 SD increase in diastolic and systolic blood pressure (BP) corresponded to a 5.5% (CI 2.9-8.0%) and 4.7% (CI 2.1-7.4%) increase in dp-ucMGP, respectively, when adjusted for age and sex.
+
+ CONCLUSION: Plasma dp-ucMGP levels were positively associated with obesity, BP, ePWV, and history of cardiovascular disease. These findings support that dp-ucMGP is a biomarker of cardiovascular risk, and that vitamin K status could play a role in vascular calcification. The strong association with obesity deserves further attention. Copyright © 2020 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Calcium-Binding Proteins). 0 (Extracellular Matrix Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.clinbiochem.2020.05.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jespersen&issn=0009-9120&title=Clinical+Biochemistry&atitle=Uncarboxylated+matrix+Gla-protein%3A+A+biomarker+of+vitamin+K+status+and+cardiovascular+risk.&volume=83&issue=&spage=49&epage=56&date=2020&doi=10.1016%2Fj.clinbiochem.2020.05.005&pmid=32422228&sid=OVID:medline
+
+<1084>
+Unique Identifier
+ 31386826
+Title
+ Effects of high-intensity interval training and nutrition advice on cardiometabolic markers and aerobic fitness in adolescent girls with obesity.
+Source
+ Applied Physiology, Nutrition, & Metabolism = Physiologie Appliquee, Nutrition et Metabolisme. 45(3):294-300, 2020 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Plavsic L; Knezevic OM; Sovtic A; Minic P; Vukovic R; Mazibrada I; Stanojlovic O; Hrncic D; Rasic-Markovic A; Macut D
+Authors Full Name
+ Plavsic, Ljiljana; Knezevic, Olivera M; Sovtic, Aleksandar; Minic, Predrag; Vukovic, Rade; Mazibrada, Ilijana; Stanojlovic, Olivera; Hrncic, Dragan; Rasic-Markovic, Aleksandra; Macut, Djuro.
+Institution
+ Plavsic, Ljiljana. Department of Pediatric and Adolescent Gynecology, Mother and Child Health Care Institute of Serbia "Dr Vukan Cupic", Radoja Dakica 6-8, 11070 Belgrade, Serbia.
+ Knezevic, Olivera M. Institute for Medical Research, University of Belgrade, Dr Subotica 4, 11000 Belgrade, Serbia.
+ Sovtic, Aleksandar. Department of Pulmonology, Mother and Child Health Care Institute of Serbia "Dr Vukan Cupic", Radoja Dakica 6-8, 11070 Belgrade, Serbia.
+ Sovtic, Aleksandar. School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
+ Minic, Predrag. Department of Pulmonology, Mother and Child Health Care Institute of Serbia "Dr Vukan Cupic", Radoja Dakica 6-8, 11070 Belgrade, Serbia.
+ Minic, Predrag. School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
+ Vukovic, Rade. School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
+ Vukovic, Rade. Department of Endocrinology, Mother and Child Health Care Institute of Serbia "Dr Vukan Cupic", Radoja Dakica 6-8, 11070 Belgrade, Serbia.
+ Mazibrada, Ilijana. Department of Pediatric and Adolescent Gynecology, Mother and Child Health Care Institute of Serbia "Dr Vukan Cupic", Radoja Dakica 6-8, 11070 Belgrade, Serbia.
+ Stanojlovic, Olivera. Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.
+ Hrncic, Dragan. Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.
+ Rasic-Markovic, Aleksandra. Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.
+ Macut, Djuro. Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, Serbia.
+MeSH Subject Headings
+ Adolescent
+ Adolescent Nutritional Physiological Phenomena
+ Adult
+ Biomarkers/bl [Blood]
+ *Cardiorespiratory Fitness/ph [Physiology]
+ *Cardiovascular Diseases/bl [Blood]
+ Female
+ *High-Intensity Interval Training/mt [Methods]
+ Humans
+ *Metabolic Diseases/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/th [Therapy]
+ *Patient Education as Topic/mt [Methods]
+ *Pediatric Obesity/bl [Blood]
+ *Pediatric Obesity/th [Therapy]
+ Young Adult
+Keyword Heading
+ HIIT
+ adolescents
+ aptitude cardiorespiratoire
+ cardiorespiratory fitness
+ cardiovascular risk
+ hypocaloric diet
+ insulin sensitivity
+ obesity
+ obesite
+ risque cardiovasculaire
+ regime hypocalorique
+ sensibilite a l'insuline
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The aim of the study was to compare the effects of high-intensity interval training (HIIT) and nutrition advice on cardiometabolic biomarkers, hormonal parameters, and cardiorespiratory fitness in adolescent girls with obesity. Adolescent girls with obesity (n = 44, aged 13-19 years) were randomized into a 12-week intervention as follows: (i) dietary advice and HIIT (n = 22), and (ii) dietary advice only (n = 22). The concentration of biomarkers of inflammation, biochemical and hormonal testing, oral glucose tolerance test, cardiorespiratory fitness, physical activity levels, and nutrition were assessed. After a 3-month intervention, the diet+HIIT group significantly increased insulin sensitivity index (-0.34 +/- 1.52 vs. 1.05 +/- 3.21; p = 0.001) and work load (0.6 +/- 11.3 W vs. 14.6 +/- 20.2 W; p = 0.024) and decreased glucose area under the curve (-0.29 +/- 4.69 vs. -0.98 +/- 4.06; p = 0.040), insulin area under the curve (-9.65 +/- 117.9 vs. -98.7 +/- 201.8; p = 0.003), and high-sensitivity C-reactive protein (hs-CRP) (0.12 +/- 1.92 mg/L vs. -1.47 +/- 3.67 mg/L; p = 0.039) in comparison with the diet group. Regarding within-group changes, both groups had significant improvements in body mass index (BMI), BMI-standard deviation score, body fat percentage, and systolic blood pressure. Positive impact on waist circumference, waist circumference/height ratio, diastolic blood pressure, hs-CRP, work load, maximal heart rate, and resting heart rate was observed only after the diet+HIIT intervention. No significant change was noted in peak oxygen uptake, lipid profile, and hormonal parameters between groups after intervention. Novelty HIIT and nutrition advice increased insulin sensitivity and decreased BMI, body fat, systolic blood pressure, and diastolic blood pressure. Nutrition advice decreased BMI, body fat, and systolic blood pressure in adolescent girls with obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1139%2fapnm-2019-0137
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Plavsic&issn=1715-5312&title=Applied+Physiology%2C+Nutrition%2C+%26+Metabolism+%3D+Physiologie+Appliquee%2C+Nutrition+et+Metabolisme&atitle=Effects+of+high-intensity+interval+training+and+nutrition+advice+on+cardiometabolic+markers+and+aerobic+fitness+in+adolescent+girls+with+obesity.&volume=45&issue=3&spage=294&epage=300&date=2020&doi=10.1139%2Fapnm-2019-0137&pmid=31386826&sid=OVID:medline
+
+<1085>
+Unique Identifier
+ 31382793
+Title
+ Multivitamins and Nutritional Adequacy in Middle-Aged to Older Americans by Obesity Status.
+Source
+ Journal of Dietary Supplements. 17(6):684-697, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Frankenfeld CL; Wallace TC
+Author NameID
+ Frankenfeld, Cara L; ORCID: http://orcid.org/0000-0002-2318-0791
+ Wallace, Taylor C; ORCID: http://orcid.org/0000-0002-9403-2745
+Authors Full Name
+ Frankenfeld, Cara L; Wallace, Taylor C.
+Institution
+ Frankenfeld, Cara L. Department of Global and Community Health, George Mason University, Fairfax, VA, USA.
+ Wallace, Taylor C. Department of Nutrition and Food Studies, George Mason University, Fairfax, VA, USA.
+ Wallace, Taylor C. Think Healthy Group, Inc, Washington, DC, USA.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Diet
+ Dietary Supplements
+ Humans
+ *Micronutrients
+ Middle Aged
+ Nutrition Surveys
+ *Nutritional Status
+ *Obesity/ep [Epidemiology]
+ United States
+ *Vitamins
+Keyword Heading
+ dietary supplement
+ multivitamin
+ nutrient
+ nutritional biomarker
+ obesity
+ usual intake
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Multivitamins are the most commonly consumed dietary supplement in the United States and worldwide. Micronutrient insufficiency and clinical deficiency are more common in middle-aged to older adults, and multivitamin use has been shown to improve status in this population. This analysis aimed to assess contributions of sporadic and consistent multivitamin use to total usual micronutrient intakes and associated nutritional biomarkers among middle-aged to older US adults age >=51 years, stratified by obesity status. Self-reported dietary intake and laboratory measures from the National Health and Nutrition Examination Survey were used in these analyses. The National Cancer Institute method was used to assess usual intakes of 18 micronutrients. Compared with food alone, multivitamin use was associated with a lower prevalence of inadequacies and improved nutritional biomarker status for folate, iodine, selenium, and vitamins B6, B12, and D. Consistent use decreased the prevalence of inadequacy for most micronutrients assessed, except for those micronutrients typically not found (or in miniscule amounts) in standard multivitamin products. In addition to a lower prevalence of inadequacy for many micronutrients associated with consistent use of multivitamins, sporadic use decreased the prevalence of inadequacy for a greater number of micronutrients in obese versus nonobese individuals. Multivitamin use (sporadic and consistent) also increased the proportion of individuals who exceeded the tolerable upper intake level for folic acid to 8%-10%. Nutritional biomarker data indicate that obese individuals may be at greater risk of clinical deficiency in vitamins B6 and D. Use of gender- and age-specific multivitamins may serve as a practical means to increase micronutrient status and decrease prevalences of clinical deficiency in the middle-aged to older population, particularly in those who are obese.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Micronutrients). 0 (Vitamins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f19390211.2019.1645785
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Frankenfeld&issn=1939-0211&title=Journal+of+Dietary+Supplements&atitle=Multivitamins+and+Nutritional+Adequacy+in+Middle-Aged+to+Older+Americans+by+Obesity+Status.&volume=17&issue=6&spage=684&epage=697&date=2020&doi=10.1080%2F19390211.2019.1645785&pmid=31382793&sid=OVID:medline
+
+<1086>
+Unique Identifier
+ 31359247
+Title
+ Asthma Phenotypes as a Guide for Current and Future Biologic Therapies. [Review]
+Source
+ Clinical Reviews in Allergy & Immunology. 59(2):160-174, 2020 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hamilton D; Lehman H
+Author NameID
+ Lehman, Heather; ORCID: http://orcid.org/0000-0002-7553-9751
+Authors Full Name
+ Hamilton, Daniel; Lehman, Heather.
+Institution
+ Hamilton, Daniel. SUNY Upstate Medical University College of Medicine, Syracuse, NY, USA.
+ Lehman, Heather. Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1001 Main Street, Buffalo, NY, 14203, USA. hkm@buffalo.edu.
+MeSH Subject Headings
+ Aspergillosis, Allergic Bronchopulmonary/co [Complications]
+ Aspergillosis, Allergic Bronchopulmonary/im [Immunology]
+ Aspergillosis, Allergic Bronchopulmonary/mi [Microbiology]
+ *Asthma/di [Diagnosis]
+ Asthma/et [Etiology]
+ *Asthma/th [Therapy]
+ Biological Products/pd [Pharmacology]
+ Biological Products/tu [Therapeutic Use]
+ Biological Therapy/mt [Methods]
+ *Biological Therapy
+ Biomarkers
+ Disease Management
+ Disease Susceptibility
+ Eosinophilia/im [Immunology]
+ Eosinophilia/me [Metabolism]
+ Eosinophilia/pa [Pathology]
+ Exercise
+ Humans
+ Immunoglobulin E/im [Immunology]
+ Neutrophils/im [Immunology]
+ Neutrophils/me [Metabolism]
+ Neutrophils/pa [Pathology]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Phenotype
+ Practice Guidelines as Topic
+ Th2 Cells/im [Immunology]
+ Th2 Cells/me [Metabolism]
+ Treatment Outcome
+Keyword Heading
+ Asthma
+ Endotypes
+ Eosinophils
+ IL-13
+ IL-4
+ IL-5
+ IgE
+ Thymic stromal lymphopoietin (TSLP)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Asthma has been increasingly recognized as being a heterogeneous disease with multiple distinct mechanisms and pathophysiologies. Evidence continues to build regarding the existence of different cell types, environmental exposures, pathogens, and other factors that produce a similar set of symptoms known collectively as asthma. This has led to a movement from a "one size fits all" symptom-based methodology to a more patient-centered, individualized approach to asthma treatment targeting the underlying disease process. A significant contributor to this shift to more personalized asthma therapy has been the increasing availability of numerous biologic therapies in recent years, providing the opportunity for more targeted treatments. When targeted biologics began to be developed for treatment of asthma, the hope was that distinct biomarkers would become available, allowing the clinician to determine which biologic therapy was best suited for which patients. Presence of certain biomarkers, like eosinophilia or antigen-specific IgE, is important features of specific asthma phenotypes. Currently available biomarkers can help with decision making about biologics, but are generally too broad and non-specific to clearly identify an asthma phenotype or the single biologic best suited to an asthmatic. Identification of further biomarkers is the subject of intense research. Yet, identifying a patient's asthma phenotype can help in predicting disease course, response to treatment, and biologic therapies to consider. In this review, major asthma phenotypes are reviewed, and the evidence for the utility of various biologics, both those currently on the market and those in the development process, in each of these phenotypes is explored.
+Registry Number/Name of Substance
+ 0 (Biological Products). 0 (Biomarkers). 37341-29-0 (Immunoglobulin E).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs12016-019-08760-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hamilton&issn=1080-0549&title=Clinical+Reviews+in+Allergy+%26+Immunology&atitle=Asthma+Phenotypes+as+a+Guide+for+Current+and+Future+Biologic+Therapies.&volume=59&issue=2&spage=160&epage=174&date=2020&doi=10.1007%2Fs12016-019-08760-x&pmid=31359247&sid=OVID:medline
+
+<1087>
+Unique Identifier
+ 31346930
+Title
+ Elevated Levels of Circulating miR-92a Are Associated with Impaired Glucose Homeostasis in Patients with Obesity and Correlate with Metabolic Status After Bariatric Surgery.
+Source
+ Obesity Surgery. 30(1):174-179, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cereijo R; Taxeras SD; Piquer-Garcia I; Pellitero S; Martinez E; Tarasco J; Moreno P; Balibrea J; Puig-Domingo M; Jimenez-Pavon D; Lerin C; Villarroya F; Sanchez-Infantes D
+Author NameID
+ Sanchez-Infantes, David; ORCID: https://orcid.org/0000-0001-6086-7501
+Authors Full Name
+ Cereijo, Ruben; Taxeras, Siri D; Piquer-Garcia, Irene; Pellitero, Silvia; Martinez, Eva; Tarasco, Jordi; Moreno, Pau; Balibrea, Jose; Puig-Domingo, Manel; Jimenez-Pavon, David; Lerin, Carles; Villarroya, Francesc; Sanchez-Infantes, David.
+Institution
+ Cereijo, Ruben. Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona, Barcelona, Catalonia, Spain.
+ Cereijo, Ruben. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Barcelona, Catalonia, Spain.
+ Taxeras, Siri D. Germans Trias i Pujol Research Institute, Campus Can Ruti, Carretera de Can Ruti, Cami de les Escoles s/n, Badalona, 08916, Barcelona, Spain.
+ Piquer-Garcia, Irene. Germans Trias i Pujol Research Institute, Campus Can Ruti, Carretera de Can Ruti, Cami de les Escoles s/n, Badalona, 08916, Barcelona, Spain.
+ Pellitero, Silvia. Germans Trias i Pujol Research Institute, Campus Can Ruti, Carretera de Can Ruti, Cami de les Escoles s/n, Badalona, 08916, Barcelona, Spain.
+ Pellitero, Silvia. Biomedical Research Center (Red Fisiopatologia de la Diabetes y enfermedades metabolicas) (CIBERDEM), ISCIII, Madrid, Spain.
+ Martinez, Eva. Germans Trias i Pujol Research Institute, Campus Can Ruti, Carretera de Can Ruti, Cami de les Escoles s/n, Badalona, 08916, Barcelona, Spain.
+ Tarasco, Jordi. Germans Trias i Pujol Research Institute, Campus Can Ruti, Carretera de Can Ruti, Cami de les Escoles s/n, Badalona, 08916, Barcelona, Spain.
+ Moreno, Pau. Germans Trias i Pujol Research Institute, Campus Can Ruti, Carretera de Can Ruti, Cami de les Escoles s/n, Badalona, 08916, Barcelona, Spain.
+ Balibrea, Jose. Metabolic and Bariatric Surgery Unit, EAC-BS Center of Excellence, Vall d'Hebron University Hospital, Barcelona, Spain.
+ Puig-Domingo, Manel. Germans Trias i Pujol Research Institute, Campus Can Ruti, Carretera de Can Ruti, Cami de les Escoles s/n, Badalona, 08916, Barcelona, Spain.
+ Puig-Domingo, Manel. Biomedical Research Center (Red Fisiopatologia de la Diabetes y enfermedades metabolicas) (CIBERDEM), ISCIII, Madrid, Spain.
+ Jimenez-Pavon, David. MOVE-IT Research group and Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cadiz, Spain.
+ Jimenez-Pavon, David. Institute of Research and Innovation in Biomedical Sciences of the Province of Cadiz (INiBICA), University of Cadiz, Cadiz, Spain.
+ Lerin, Carles. Institut de Recerca Sant Joan de Deu, Barcelona, Catalonia, Spain.
+ Villarroya, Francesc. Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona, Barcelona, Catalonia, Spain. fvillarroya@ub.edu.
+ Villarroya, Francesc. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Barcelona, Catalonia, Spain. fvillarroya@ub.edu.
+ Villarroya, Francesc. Institut de Recerca Sant Joan de Deu, Barcelona, Catalonia, Spain. fvillarroya@ub.edu.
+ Sanchez-Infantes, David. Germans Trias i Pujol Research Institute, Campus Can Ruti, Carretera de Can Ruti, Cami de les Escoles s/n, Badalona, 08916, Barcelona, Spain. dsanchez@igtp.cat.
+MeSH Subject Headings
+ Adult
+ Bariatric Surgery/rh [Rehabilitation]
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Case-Control Studies
+ Cohort Studies
+ Female
+ *Glucose Intolerance/bl [Blood]
+ Glucose Intolerance/ge [Genetics]
+ Homeostasis/ge [Genetics]
+ Humans
+ Male
+ *MicroRNAs/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ *Obesity/su [Surgery]
+ Postoperative Period
+ Treatment Outcome
+ Young Adult
+Keyword Heading
+ Bariatric surgery
+ Brown adipose tissue
+ Obesity
+ miR-92a
+ miR-99b
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: miRNAs are small non-coding RNAs, some of which are expressed in adipose tissues, are present in the circulation, and are regulated in obesity. Bariatric surgery (BS) has been proposed to lead to activation of brown adipose tissue, an effect that may be related to beneficial effects of BS on systemic metabolism. Here, we evaluated circulating levels of miR-92a and miR-99b, two miRNAs proposed as biomarkers of brown fat activity, in a cohort of patients with severe obesity before and after BS, and studied their potential relationship with BS-associated improvements in metabolic parameters.
+
+ METHODS: Circulating levels of miR-92a and miR-99b were quantified in a cohort of 26 patients (age, 48 +/- 10 years; BMI, 45 +/- 7 kg/m2) before and 6 months after BS. Clinical parameters were determined at different time points and correlations among them were studied.
+
+ RESULTS: Basal levels of miR-92a were significantly increased in patients with obesity relative to lean controls. Serum miR-92a levels were strongly reduced at 6 months after BS, reaching levels similar to those in controls. Serum miR-99b levels were unchanged in relation to both the obese condition and BS. Elevated levels of miR-92a were directly correlated with worsened glucose homeostasis parameters and poor BS outcome.
+
+ CONCLUSIONS: Our findings show that miR-92a is elevated in conditions of obesity, and its reduction after BS correlates with metabolic improvement. Further studies would be necessary to establish miR-92a as serum biomarker and potential predictor of the BS success in improving the metabolic status of patients with obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (MIRN92 microRNA, human). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs11695-019-04104-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cereijo&issn=0960-8923&title=Obesity+Surgery&atitle=Elevated+Levels+of+Circulating+miR-92a+Are+Associated+with+Impaired+Glucose+Homeostasis+in+Patients+with+Obesity+and+Correlate+with+Metabolic+Status+After+Bariatric+Surgery.&volume=30&issue=1&spage=174&epage=179&date=2020&doi=10.1007%2Fs11695-019-04104-y&pmid=31346930&sid=OVID:medline
+
+<1088>
+Unique Identifier
+ 31340742
+Title
+ UCP2, SHBG, Leptin, and T3 Levels are Associated with Resting Energy Expenditure in Obese Women.
+Source
+ Endocrine, Metabolic & Immune Disorders Drug Targets. 20(2):234-241, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ahmadi S; Pishva H; Eshraghian MR; Hedayati M
+Authors Full Name
+ Ahmadi, Somaye; Pishva, Hamideh; Eshraghian, Mohammad R; Hedayati, Mehdi.
+Institution
+ Ahmadi, Somaye. Department of Cellular-Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Pishva, Hamideh. Department of Cellular-Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Eshraghian, Mohammad R. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
+ Hedayati, Mehdi. Cellular-Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University, Tehran, Iran.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Energy Metabolism/ph [Physiology]
+ Female
+ Humans
+ *Leptin/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Rest/ph [Physiology]
+ *Sex Hormone-Binding Globulin/me [Metabolism]
+ *Triiodothyronine/bl [Blood]
+ *Uncoupling Protein 2/bl [Blood]
+Keyword Heading
+ Obesity
+ UCP2
+ body mass index
+ leptin
+ resting energy expenditure
+ sex hormone binding globulin.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The aim of this study was to investigate the association of Sex Hormone Binding Globulin (SHBG) with leptin, Triidothyronine (T3), and Uncoupling Protein 2 (UCP2) in obese women with low and normal Resting Energy Expenditure (REE) and to determine the role of these factors in the regulation of REE in obese women.
+
+ METHOD: A total 49 subjects (25-50 years old) were selected. Anthropometric and body composition parameters and resting energy expenditure were measured. Fasting circulating leptin, T3, SHBG and UCP2 levels were measured. Subjects were divided into three groups: Group (BMI>30 and low resting energy expenditure, 16 subjects), group II (BMI>30 and normal resting energy expenditure, 17 subjects), and group (control group, 16 non-obese subjects).
+
+ RESULT: It was found that obese subjects who had higher SHBG and leptin levels were at risk for high levels of UCP2. A significant association was found between T3 and REE. Obese subjects with higher concentrations of UCP2 and SHBG had decreased resting energy expenditure. A significant association was observed between SHBG and leptin in group (r=0.90, p<0.0001) and group (r=0.83, p<0.0001). Moreover, a significant association was found between T3 and SHBG in group (r=-0.69, P=0.003).
+
+ CONCLUSION: Changes of the UCP2, leptin, and thyroid hormone (T3) levels may be related to SHBG levels. Thus, lower leptin and T3 levels may decrease SHBG in obese women. Therefore, lower SHBG, leptin, T3 and UCP2 levels may decrease the REE level in obese women. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (LEP protein, human). 0 (Leptin). 0 (SHBG protein, human). 0 (Sex Hormone-Binding Globulin). 0 (UCP2 protein, human). 0 (Uncoupling Protein 2). 06LU7C9H1V (Triiodothyronine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2174%2f1871530319666190723154147
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ahmadi&issn=1871-5303&title=Endocrine%2C+Metabolic+%26+Immune+Disorders+Drug+Targets&atitle=UCP2%2C+SHBG%2C+Leptin%2C+and+T3+Levels+are+Associated+with+Resting+Energy+Expenditure+in+Obese+Women.&volume=20&issue=2&spage=234&epage=241&date=2020&doi=10.2174%2F1871530319666190723154147&pmid=31340742&sid=OVID:medline
+
+<1089>
+Unique Identifier
+ 31171461
+Title
+ Liraglutide vs. lixisenatide in obese type 2 diabetes mellitus patients: What effect should we expect in routine clinical practice?.
+Source
+ Primary care diabetes. 14(1):68-74, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moreno-Fernandez J; Garcia-Seco JA; Seco Segura AM; Garcia-Seco F; Rozas Moreno PJ; Aguirre Sanchez-Covisa M
+Authors Full Name
+ Moreno-Fernandez, Jesus; Garcia-Seco, Jose Alberto; Seco Segura, Angela Maria; Garcia-Seco, Fernando; Rozas Moreno, Pedro Jesus; Aguirre Sanchez-Covisa, Miguel.
+Institution
+ Moreno-Fernandez, Jesus. Endocrinology and Nutrition Department, Ciudad Real General University Hospital, C/Obispo Rafael Torija, s/n. Ciudad Real, 13005, Spain. Electronic address: jmorenof@sescam.jccm.es.
+ Garcia-Seco, Jose Alberto. Endocrinology and Nutrition Department, Ciudad Real General University Hospital, C/Obispo Rafael Torija, s/n. Ciudad Real, 13005, Spain.
+ Seco Segura, Angela Maria. Endocrinology and Nutrition Department, Ciudad Real General University Hospital, C/Obispo Rafael Torija, s/n. Ciudad Real, 13005, Spain.
+ Garcia-Seco, Fernando. Cordoba University, Avd. Medina Azahara. 5, Cordoba, 14071 Spain.
+ Rozas Moreno, Pedro Jesus. Endocrinology and Nutrition Department, Ciudad Real General University Hospital, C/Obispo Rafael Torija, s/n. Ciudad Real, 13005, Spain.
+ Aguirre Sanchez-Covisa, Miguel. Endocrinology and Nutrition Department, Ciudad Real General University Hospital, C/Obispo Rafael Torija, s/n. Ciudad Real, 13005, Spain.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Female
+ Glucagon-Like Peptide-1 Receptor/ag [Agonists]
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Hypoglycemic Agents/ae [Adverse Effects]
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ Liraglutide/ae [Adverse Effects]
+ *Liraglutide/tu [Therapeutic Use]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Peptides/ae [Adverse Effects]
+ *Peptides/tu [Therapeutic Use]
+ Prospective Studies
+ Spain
+ Time Factors
+ Treatment Outcome
+ *Weight Loss/de [Drug Effects]
+Keyword Heading
+ GLP-1 receptor agonists
+ Liraglutide
+ Lixisenatide
+ Obesity
+ Routine clinical practice
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Liraglutide and lixisenatide improved glycemic control, weight and cardiovascular risk factors (CVRF) in type 2 diabetes mellitus (T2DM) patients. Our objective was to analyze clinical efficacy and safety differences in routine clinical practice.
+
+ METHODS: A 24-week prospective observational study to compare the effect of liraglutide versus lixisenatide in obese T2DM patients in routine clinical practice. The main objective was to analyze between-group glycosylated hemoglobin (HbA1c) differences at the end of the study. Secondary objectives included differences in body weight, other CVRF, changes in medication, side effects, satisfaction and safety.
+
+ RESULTS: A total of 100 patients (50 liraglutide, 50 lixisenatide) were included. Both groups experienced a decrease in HbA1c values (liraglutide, -1.4%, CI 95% -2, -0.8, P<0.001 vs. lixisenatide, -0.8%, 95% CI -1.2, -0.5, P<0.001). No differences were found in final HbA1c values between both groups (liraglutide 7.3+/-0.9% vs. lixisenatide 7.2+/-1.5%, P=0.7). We did not detect between groups differences in anthropometric variables or CVRF at the study end. A lower proportion of patients received treatment with a maximum dose of liraglutide compared with lixisenatide (27% vs. 95%, P<0.001). In contrast, a greater percentage of patients in the lixisenatide group than in liraglutide group (29% vs. 9%, P=0.026) intensified treatment by the addition of sodium-glucose transporter type 2 inhibitors. Adverse events were less frequently reported in liraglutide treated patients compared with lixisentatide (80% vs. 96%, P=0.014). No serious adverse events were detected.
+
+ CONCLUSIONS: These results confirm the efficacy and safety of liraglutide and lixisenatide in routine clinical practice. Moreover, a different therapeutic effect between liraglutide and lixisenatide was detected. Copyright © 2019 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (GLP1R protein, human). 0 (Glucagon-Like Peptide-1 Receptor). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (Peptides). 0 (hemoglobin A1c protein, human). 74O62BB01U (lixisenatide). 839I73S42A (Liraglutide).
+Publication Type
+ Comparative Study. Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.pcd.2019.05.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moreno-Fernandez&issn=1878-0210&title=Primary+care+diabetes&atitle=Liraglutide+vs.+lixisenatide+in+obese+type+2+diabetes+mellitus+patients%3A+What+effect+should+we+expect+in+routine+clinical+practice%3F.&volume=14&issue=1&spage=68&epage=74&date=2020&doi=10.1016%2Fj.pcd.2019.05.006&pmid=31171461&sid=OVID:medline
+
+<1090>
+Unique Identifier
+ 31108554
+Title
+ Circulating FGF21 Levels in Human Health and Metabolic Disease. [Review]
+Source
+ Experimental & Clinical Endocrinology & Diabetes. 128(11):752-770, 2020 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Keuper M; Haring HU; Staiger H
+Authors Full Name
+ Keuper, Michaela; Haring, Hans-Ulrich; Staiger, Harald.
+Institution
+ Keuper, Michaela. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tubingen, Tubingen, Germany.
+ Keuper, Michaela. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Keuper, Michaela. Department of Molecular Bioscience, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
+ Haring, Hans-Ulrich. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tubingen, Tubingen, Germany.
+ Haring, Hans-Ulrich. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Haring, Hans-Ulrich. Interfaculty Centre for Pharmacogenomics and Pharma Research at the Eberhard Karls University Tubingen, Tubingen, Germany.
+ Haring, Hans-Ulrich. Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany.
+ Staiger, Harald. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tubingen, Tubingen, Germany.
+ Staiger, Harald. German Center for Diabetes Research (DZD), Neuherberg, Germany.
+ Staiger, Harald. Interfaculty Centre for Pharmacogenomics and Pharma Research at the Eberhard Karls University Tubingen, Tubingen, Germany.
+ Staiger, Harald. Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University Tubingen, Tubingen, Germany.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Endopeptidases/me [Metabolism]
+ *Fibroblast Growth Factors/bl [Blood]
+ Humans
+ *Membrane Proteins/me [Metabolism]
+ *Metabolic Diseases/bl [Blood]
+ Metabolic Diseases/di [Diagnosis]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+Abstract
+ Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as a hepatokine. This hormone circulates to its target tissues (e. g., brain, adipose tissue), which requires two components, one of the preferred FGF receptor isoforms (FGFR1c and FGFR3c) and the co-factor beta-Klotho (KLB) to trigger downstream signaling pathways. Although targeting FGF21 signaling in humans by analogues and receptor agonists results in beneficial effects, e. g., improvements in plasma lipids and decreased body weight, it failed to recapitulate the improvements in glucose handling shown for many mouse models. FGF21's role and metabolic effects in mice and its therapeutic potential have extensively been reviewed elsewhere. In this review we focus on circulating FGF21 levels in humans and their associations with disease and clinical parameters, focusing primarily on obesity and obesity-associated diseases such as type-2 diabetes. We provide a comprehensive overview on human circulating FGF21 levels under normal physiology and metabolic disease. We discuss the emerging field of inactivating FGF21 in human blood by fibroblast activation protein (FAP) and its potential clinical implications. Copyright Thieme. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FGF21 protein, human). 0 (Membrane Proteins). 62031-54-3 (Fibroblast Growth Factors). EC 3-4 (Endopeptidases). EC 3-4-21 (fibroblast activation protein alpha).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1055%2fa-0879-2968
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Keuper&issn=0947-7349&title=Experimental+%26+Clinical+Endocrinology+%26+Diabetes&atitle=Circulating+FGF21+Levels+in+Human+Health+and+Metabolic+Disease.&volume=128&issue=11&spage=752&epage=770&date=2020&doi=10.1055%2Fa-0879-2968&pmid=31108554&sid=OVID:medline
+
+<1091>
+Unique Identifier
+ 31089722
+Title
+ Increased Oxidized High-Density Lipoprotein/High-Density Lipoprotein-Cholesterol Ratio as a Potential Indicator of Disturbed Metabolic Health in Overweight and Obese Individuals.
+Source
+ Laboratory Medicine. 51(1):24-33, 2020 Jan 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Janac JM; Zeljkovic A; Jelic-Ivanovic ZD; Dimitrijevic-Sreckovic VS; Vekic J; Miljkovic MM; Stefanovic A; Kotur-Stevuljevic JM; Ivanisevic JM; Spasojevic-Kalimanovska VV
+Authors Full Name
+ Janac, Jelena M; Zeljkovic, Aleksandra; Jelic-Ivanovic, Zorana D; Dimitrijevic-Sreckovic, Vesna S; Vekic, Jelena; Miljkovic, Milica M; Stefanovic, Aleksandra; Kotur-Stevuljevic, Jelena M; Ivanisevic, Jasmina M; Spasojevic-Kalimanovska, Vesna V.
+Institution
+ Janac, Jelena M. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+ Zeljkovic, Aleksandra. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+ Jelic-Ivanovic, Zorana D. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+ Dimitrijevic-Sreckovic, Vesna S. Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia; Faculty of Medicine, University of Belgrade, Republic of Serbia.
+ Vekic, Jelena. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+ Miljkovic, Milica M. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+ Stefanovic, Aleksandra. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+ Kotur-Stevuljevic, Jelena M. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+ Ivanisevic, Jasmina M. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+ Spasojevic-Kalimanovska, Vesna V. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Republic of Serbia.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Cholesterol, HDL/bl [Blood]
+ Female
+ Humans
+ *Lipoproteins, LDL/bl [Blood]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+Keyword Heading
+ HDL-cholesterol
+ lipoprotein subfractions
+ metabolically healthy phenotype
+ overweight and obesity
+ oxidized HDL
+ serum amyloid A
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: We evaluated the qualitative characteristics of high-density lipoprotein (HDL) particles in metabolically healthy and unhealthy overweight and obese subjects.
+
+ METHODS: The study involved 115 subject individuals classified as metabolically healthy and unhealthy, as in overweight and obese groups. Commercial enzyme-linked immunosorbent assay (ELISA) kits were used to measure oxidized HDL (OxHDL) and serum amyloid A (SAA) concentrations. Lipoprotein subfractions were separated using nondenaturing gradient gel electrophoresis.
+
+ RESULTS: An independent association was shown between increased OxHDL/HDL-cholesterol ratio and the occurrence of metabolically unhealthy phenotype in the overweight and obese groups. The OxHDL/HDL-cholesterol ratio showed excellent and acceptable diagnostic accuracy in determination of metabolic health phenotypes (overweight group, AUC = 0.881; obese group, AUC = 0.765). Accumulation of smaller HDL particles in metabolically unhealthy subjects was verified by lipoprotein subfraction analysis. SAA concentrations did not differ significantly between phenotypes.
+
+ CONCLUSIONS: Increased OxHDL/HDL-cholesterol ratio may be a potential indicator of disturbed metabolic health in overweight and obese individuals. Copyright © American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Lipoproteins, LDL). 0 (oxidized low density lipoprotein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1093%2flabmed%2flmz017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Janac&issn=0007-5027&title=Laboratory+Medicine&atitle=Increased+Oxidized+High-Density+Lipoprotein%2FHigh-Density+Lipoprotein-Cholesterol+Ratio+as+a+Potential+Indicator+of+Disturbed+Metabolic+Health+in+Overweight+and+Obese+Individuals.&volume=51&issue=1&spage=24&epage=33&date=2020&doi=10.1093%2Flabmed%2Flmz017&pmid=31089722&sid=OVID:medline
+
+<1092>
+Unique Identifier
+ 31062082
+Title
+ Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses.
+Source
+ Clinical Research in Cardiology. 109(1):22-33, 2020 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ferreira JP; Pizard A; Machu JL; Bresso E; Rocca HB; Girerd N; Leroy C; Gonzalez A; Diez J; Heymans S; Devignes MD; Rossignol P; Zannad F
+Author NameID
+ Ferreira, Joao Pedro; ORCID: http://orcid.org/0000-0002-2304-6138
+Corporate Author
+ FIBRO-TARGETS investigators
+Authors Full Name
+ Ferreira, Joao Pedro; Pizard, Anne; Machu, Jean-Loup; Bresso, Emmanuel; Rocca, Hans-Peter Brunner-La; Girerd, Nicolas; Leroy, Celine; Gonzalez, Arantxa; Diez, Javier; Heymans, Stephane; Devignes, Marie-Dominique; Rossignol, Patrick; Zannad, Faiez.
+Institution
+ Ferreira, Joao Pedro. Universite de Lorraine, Centre d'Investigation Clinique- Plurithematique Inserm CIC-P 1433, and Inserm U1116, CHRU Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France. j.ferreira@chru-nancy.fr.
+ Ferreira, Joao Pedro. Department of Physiology, University of Porto, Porto, Portugal. j.ferreira@chru-nancy.fr.
+ Ferreira, Joao Pedro. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands. j.ferreira@chru-nancy.fr.
+ Pizard, Anne. Universite de Lorraine, Centre d'Investigation Clinique- Plurithematique Inserm CIC-P 1433, and Inserm U1116, CHRU Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
+ Pizard, Anne. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Machu, Jean-Loup. Universite de Lorraine, Centre d'Investigation Clinique- Plurithematique Inserm CIC-P 1433, and Inserm U1116, CHRU Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
+ Machu, Jean-Loup. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Bresso, Emmanuel. Universite de Lorraine, CNRS, Inria, LORIA, Nancy, 54500, France.
+ Bresso, Emmanuel. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Rocca, Hans-Peter Brunner-La. Department of Cardiology, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands.
+ Rocca, Hans-Peter Brunner-La. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Girerd, Nicolas. Universite de Lorraine, Centre d'Investigation Clinique- Plurithematique Inserm CIC-P 1433, and Inserm U1116, CHRU Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
+ Girerd, Nicolas. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Leroy, Celine. Universite de Lorraine, Centre d'Investigation Clinique- Plurithematique Inserm CIC-P 1433, and Inserm U1116, CHRU Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
+ Leroy, Celine. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Gonzalez, Arantxa. Program of Cardiovascular Diseases, Centre of Applied Medical Research, University of Navarra, Pamplona, Spain.
+ Gonzalez, Arantxa. CIBERCV, Carlos III Institute of Health, Madrid, Spain.
+ Gonzalez, Arantxa. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Diez, Javier. Program of Cardiovascular Diseases, Centre of Applied Medical Research, University of Navarra, Pamplona, Spain.
+ Diez, Javier. CIBERCV, Carlos III Institute of Health, Madrid, Spain.
+ Diez, Javier. Departments of Cardiology and Cardiac Surgery and Nephrology, Clinic University of Navarra, Pamplona, Spain.
+ Diez, Javier. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Heymans, Stephane. Departments of Cardiology and Cardiac Surgery and Nephrology, Clinic University of Navarra, Pamplona, Spain.
+ Heymans, Stephane. Department of Cardiology, CARIM School for Cardiovascular Diseases Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
+ Heymans, Stephane. Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.
+ Heymans, Stephane. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Devignes, Marie-Dominique. Universite de Lorraine, CNRS, Inria, LORIA, Nancy, 54500, France.
+ Devignes, Marie-Dominique. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Rossignol, Patrick. Universite de Lorraine, Centre d'Investigation Clinique- Plurithematique Inserm CIC-P 1433, and Inserm U1116, CHRU Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
+ Rossignol, Patrick. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+ Zannad, Faiez. Universite de Lorraine, Centre d'Investigation Clinique- Plurithematique Inserm CIC-P 1433, and Inserm U1116, CHRU Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
+ Zannad, Faiez. The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Proteins/me [Metabolism]
+ Case-Control Studies
+ Diabetes Mellitus/bl [Blood]
+ *Diabetes Mellitus/pp [Physiopathology]
+ Female
+ Humans
+ Hypertension/bl [Blood]
+ *Hypertension/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Phenotype
+ Proteomics
+ Risk Factors
+Keyword Heading
+ Cardiovascular diseases
+ Complex networks
+ Decision tree
+ LASSO
+ Phenotypes
+ Proteomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hypertension, obesity and diabetes are major and potentially modifiable "risk factors" for cardiovascular diseases. Identification of biomarkers specific to these risk factors may help understanding the underlying pathophysiological pathways, and developing individual treatment.
+
+ METHODS: The FIBRO-TARGETS (targeting cardiac fibrosis for heart failure treatment) consortium has merged data from 12 patient cohorts in 1 common database of > 12,000 patients. Three mutually exclusive main phenotypic groups were identified ("cases"): (1) "hypertensive"; (2) "obese"; and (3) "diabetic"; age-sex matched in a 1:2 proportion with "healthy controls" without any of these phenotypes. Proteomic associations were studied using a biostatistical method based on LASSO and confronted with machine-learning and complex network approaches.
+
+ RESULTS: The case:control distribution by each cardiovascular phenotype was hypertension (50:100), obesity (50:98), and diabetes (36:72). Of the 86 studied proteins, 4 were found to be independently associated with hypertension: GDF-15, LEP, SORT-1 and FABP-2; 3 with obesity: CEACAM-8, LEP and PRELP; and 4 with diabetes: GDF-15, REN, CXCL-1 and SCF. GDF-15 (hypertension + diabetes) and LEP (hypertension + obesity) are shared by 2 different phenotypes. A machine-learning approach confirmed GDF-15, LEP and SORT-1 as discriminant biomarkers for the hypertension group, and LEP plus PRELP for the obesity group. Complex network analyses provided insight on the mechanisms underlying these disease phenotypes where fibrosis may play a central role.
+
+ CONCLUSION: Patients with "mutually exclusive" phenotypes display distinct bioprofiles that might underpin different biological pathways, potentially leading to fibrosis. Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses. Patients with "mutually exclusive" phenotypes (blue: obesity, hypertension and diabetes) display distinct protein bioprofiles (green: decreased expression; red: increased expression) that might underpin different biological pathways (orange arrow), potentially leading to fibrosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs00392-019-01480-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ferreira&issn=1861-0684&title=Clinical+Research+in+Cardiology&atitle=Plasma+protein+biomarkers+and+their+association+with+mutually+exclusive+cardiovascular+phenotypes%3A+the+FIBRO-TARGETS+case-control+analyses.&volume=109&issue=1&spage=22&epage=33&date=2020&doi=10.1007%2Fs00392-019-01480-4&pmid=31062082&sid=OVID:medline
+
+<1093>
+Unique Identifier
+ 31036413
+Title
+ Comparative and functional analysis of plasma membrane-derived extracellular vesicles from obese vs. nonobese women.
+Source
+ Clinical Nutrition. 39(4):1067-1076, 2020 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Santamaria-Martos F; Benitez ID; Latorre J; Lluch A; Moreno-Navarrete JM; Sabater M; Ricart W; Sanchez de la Torre M; Mora S; Fernandez-Real JM; Ortega FJ
+Authors Full Name
+ Santamaria-Martos, Fernando; Benitez, Ivan D; Latorre, Jessica; Lluch, Aina; Moreno-Navarrete, Jose M; Sabater, Monica; Ricart, Wifredo; Sanchez de la Torre, Manuel; Mora, Silvia; Fernandez-Real, Jose M; Ortega, Francisco J.
+Institution
+ Santamaria-Martos, Fernando. Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain.
+ Benitez, Ivan D. Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain.
+ Latorre, Jessica. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Institut d'Investigacio Biomedica de Girona (IdIBGi), Girona, Spain.
+ Lluch, Aina. Department of Diabetes, Endocrinology, and Nutrition (UDEN), Institut d'Investigacio Biomedica de Girona (IdIBGi), Girona, Spain.
+ Moreno-Navarrete, Jose M. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Institut d'Investigacio Biomedica de Girona (IdIBGi), Girona, Spain.
+ Sabater, Monica. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Institut d'Investigacio Biomedica de Girona (IdIBGi), Girona, Spain.
+ Ricart, Wifredo. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Institut d'Investigacio Biomedica de Girona (IdIBGi), Girona, Spain.
+ Sanchez de la Torre, Manuel. Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Mora, Silvia. Department of Molecular and Cellular Physiology, Institute of Translational Medicine (ITM), University of Liverpool, Liverpool, UK. Electronic address: s.mora@liverpool.ac.uk.
+ Fernandez-Real, Jose M. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Institut d'Investigacio Biomedica de Girona (IdIBGi), Girona, Spain. Electronic address: jmfreal@idibgi.org.
+ Ortega, Francisco J. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Diabetes, Endocrinology, and Nutrition (UDEN), Institut d'Investigacio Biomedica de Girona (IdIBGi), Girona, Spain. Electronic address: fortega@idibgi.org.
+MeSH Subject Headings
+ *Adipocytes/me [Metabolism]
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Cells, Cultured
+ *Extracellular Vesicles/me [Metabolism]
+ Female
+ Humans
+ MicroRNAs/bl [Blood]
+ Middle Aged
+ *Obesity/me [Metabolism]
+Keyword Heading
+ Biomarkers
+ Exosomal vesicles
+ Insulin resistance
+ Obesity
+ Plasma
+ microRNAs
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Membrane-derived extracellular vesicles (EVs) are released to the circulation by cells found in adipose tissue, transferring microRNAs (miRNAs) that may mediate the adaptive response of recipient cells. This study investigated plasma EVs from obese vs. nonobese women and their functional impact in adipocytes.
+
+ METHODS: Plasma EVs were isolated by differential centrifugation. Concentration and size were examined by nanoparticle tracking analysis (NanoSight). RNA was purified from plasma and plasma EVs of 45 women (47 +/- 12 years, 58% of obesity) and profiles of mature miRNAs were assessed. Functional analyses were performed in human adipocytes.
+
+ FINDINGS: Smaller plasma EVs were found in obese when compared to nonobese women. Positive associations were identified between circulating EVs numbers and parameters of impaired glucose tolerance. Almost 40% of plasma cell-free miRNAs were also found in isolated plasma EVs, defined as Ct values < 37 in >=75% of samples. BMI together with parameters of insulin resistance were major contributors to EVs-contained miRNA patterns. Treatments of cultured human adipocytes with EVs from obese women led to a significant reduction of genes involved in lipid biosynthesis, while increasing the expression of IRS1 (12.3%, p = 0.002).
+
+ INTERPRETATION: Size, concentration and the miRNA cargo of plasma EVs are associated with obesity and parameters of insulin resistance. Plasma EVs may mediate intercellular communication relevant to metabolism in adipocytes. Copyright © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.clnu.2019.04.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Santamaria-Martos&issn=0261-5614&title=Clinical+Nutrition&atitle=Comparative+and+functional+analysis+of+plasma+membrane-derived+extracellular+vesicles+from+obese+vs.+nonobese+women.&volume=39&issue=4&spage=1067&epage=1076&date=2020&doi=10.1016%2Fj.clnu.2019.04.008&pmid=31036413&sid=OVID:medline
+
+<1094>
+Unique Identifier
+ 30998429
+Title
+ Lp-PLA2 as a promising predictor of comorbidities in patients with severe psoriasis.
+Source
+ Journal of Dermatological Treatment. 31(5):524-530, 2020 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kiluk P; Baran A; Swiderska M; Maciaszek M; Flisiak I
+Authors Full Name
+ Kiluk, Paulina; Baran, Anna; Swiderska, Magdalena; Maciaszek, Magdalena; Flisiak, Iwona.
+Institution
+ Kiluk, Paulina. Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.
+ Baran, Anna. Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.
+ Swiderska, Magdalena. Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
+ Maciaszek, Magdalena. Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
+ Flisiak, Iwona. Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.
+MeSH Subject Headings
+ *1-Alkyl-2-acetylglycerophosphocholine Esterase/bl [Blood]
+ Acitretin/tu [Therapeutic Use]
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ Female
+ Humans
+ Keratolytic Agents/tu [Therapeutic Use]
+ Male
+ Methotrexate/tu [Therapeutic Use]
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Psoriasis/co [Complications]
+ Psoriasis/dt [Drug Therapy]
+ *Psoriasis/pa [Pathology]
+ Risk Factors
+ Young Adult
+Keyword Heading
+ Psoriasis
+ atherosclerosis
+ cardiovascular disease
+ lipoprotein-associated phospholipase A2
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well- known risk factor of atherosclerotic vascular diseases which are common comorbidities in psoriasis. The aim of this study was to evaluate serum Lp-PLA2 level in psoriatic patients and elucidate possible associations with disease activity, metabolic or inflammatory parameters and systemic treatment. Methods: We enrolled 33 patients with active plaque-type psoriasis and 11 healthy controls. Blood samples were collected before and after 3 months of systemic treatment with acitretin or methotrexate. Serum Lp-PLA2 level were evaluated by enzyme-linked immunosorbent assay. Results: Serum Lp-PLA2 level in patients with psoriasis did not statistically differ comparing to the control group (p = .2). However, in patients with severe psoriasis Lp-PLA2 was significantly higher than in the controls before and after treatment (p = .03, p = .01, respectively). The lipase did not correlate with BMI (p = .22); however, a statistical significance was noted between psoriatics with obesity compared to the controls (p = .03). No significant effect of systemic treatment combined (p = .5) nor separately with acitretin (p = .5) or methotrexate (p = .1) on the Lp-PLA2 level was found, despite clinical improvement. Conclusion: Lp-PLA2 assay might be helpful in assessment of the risk of cardiometabolic comorbidities development especially in patients with severe psoriasis and obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Keratolytic Agents). EC 3-1-1-47 (1-Alkyl-2-acetylglycerophosphocholine Esterase). LCH760E9T7 (Acitretin). YL5FZ2Y5U1 (Methotrexate).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f09546634.2019.1606887
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kiluk&issn=0954-6634&title=Journal+of+Dermatological+Treatment&atitle=Lp-PLA2+as+a+promising+predictor+of+comorbidities+in+patients+with+severe+psoriasis.&volume=31&issue=5&spage=524&epage=530&date=2020&doi=10.1080%2F09546634.2019.1606887&pmid=30998429&sid=OVID:medline
+
+<1095>
+Unique Identifier
+ 30961460
+Title
+ Omega-3 and vitamin E co-supplementation can improve antioxidant markers in obese/overweight women with polycystic ovary syndrome.
+Source
+ International Journal for Vitamin & Nutrition Research. 90(5-6):477-483, 2020 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sadeghi F; Alavi-Naeini A; Mardanian F; Ghazvini MR; Mahaki B
+Authors Full Name
+ Sadeghi, Fatemeh; Alavi-Naeini, Amirmansour; Mardanian, Farahnaz; Ghazvini, Mohammad Reza; Mahaki, Behzad.
+Institution
+ Sadeghi, Fatemeh. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Alavi-Naeini, Amirmansour. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Mardanian, Farahnaz. Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Ghazvini, Mohammad Reza. Isfahan Center of Health Research, National Institute of Health Research, Isfahan, Iran.
+ Mahaki, Behzad. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
+MeSH Subject Headings
+ Antioxidants/ch [Chemistry]
+ Biomarkers
+ Dietary Supplements
+ Double-Blind Method
+ Female
+ Humans
+ Obesity
+ Overweight
+ Oxidative Stress
+ *Polycystic Ovary Syndrome
+ Vitamin D/me [Metabolism]
+ *Vitamin E
+Keyword Heading
+ Antioxidant markers
+ Omega-3
+ PCOS
+ Polycystic ovary syndrome
+ Vitamin E
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Polycystic ovary syndrome is one of the most important factors in female infertility. Oxidative stress is likely to contribute to increased insulin and androgen production in the ovaries, as well as probably impairing follicle production. Aims: This study aims to determine the complementary effects of omega-3 and vitamin E supplements on certain oxidative stress indices in obese and overweight women with polycystic ovary syndrome. Materials and Methods: This double-blind, randomized clinical trial was performed on polycystic ovary syndrome subjects with BMI > 25. Patients were randomly allocated into two groups to receive either 2 g of omega-3 plus 400 IU of vitamin E, or a placebo, for 8 weeks. At the beginning and the end of the study, total antioxidant capacity, glutathione levels, catalase activity, malondialdehyde concentrations, as well as dietary intake and physical activity were evaluated. Statistical analysis was performed using SPSS. Results: 32 patients in the intervention group and 30 patients in the placebo group completed the study. Co-supplementation of omega-3 and vitamin E significantly increased total antioxidant capacity (mg/dl) (1.15 +/- 0.93 vs -0.6 +/- 0.72; P < 0.001), catalase activity (IU/L) (1.19 +/- 1.06 vs 0.12 +/- 0.36; P < 0.001) and glutathione levels (mumol/L) (1.5 +/- 1.06 vs 0.23 +/- 1.43; P = 0.028). Additionally, a significant reduction of malondialdehyde levels (nmol/L) (-0.34 +/- 0.32 vs 0.57 +/- 2.20; P = 0.008) was observed, in comparison with placebo. Conclusion: Co-supplementation with omega-3 and vitamin E had beneficial effect on total antioxidant capacity, malondialdehyde concentrations, glutathione levels and catalase activity.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 1406-16-2 (Vitamin D). 1406-18-4 (Vitamin E).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1024%2f0300-9831%2fa000588
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sadeghi&issn=0300-9831&title=International+Journal+for+Vitamin+%26+Nutrition+Research&atitle=Omega-3+and+vitamin+E+co-supplementation+can+improve+antioxidant+markers+in+obese%2Foverweight+women+with+polycystic+ovary+syndrome.&volume=90&issue=5-6&spage=477&epage=483&date=2020&doi=10.1024%2F0300-9831%2Fa000588&pmid=30961460&sid=OVID:medline
+
+<1096>
+Unique Identifier
+ 30950168
+Title
+ Relationship between normal weight obesity and mild cognitive impairment is reflected in cognitive-related genes in human peripheral blood mononuclear cells.
+Source
+ Psychogeriatrics:The Official Journal of the Japanese Psychogeriatric Society. 20(1):35-43, 2020 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang S; Zhao M; Wang F; Liu J; Zheng H; Lei P
+Author NameID
+ Lei, Ping; ORCID: https://orcid.org/0000-0001-8770-1819
+Authors Full Name
+ Zhang, Shishuang; Zhao, Minghui; Wang, Feng; Liu, Juan; Zheng, Hui; Lei, Ping.
+Institution
+ Zhang, Shishuang. Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Geriatrics Institute, Tianjin, China.
+ Zhao, Minghui. Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Geriatrics Institute, Tianjin, China.
+ Wang, Feng. Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Geriatrics Institute, Tianjin, China.
+ Liu, Juan. Department of Ultrasound, Tianjin People's Hospital, Tianjin, China.
+ Zheng, Hui. Nankai Center for Disease Control and Prevention, Tianjin, China.
+ Lei, Ping. Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Geriatrics Institute, Tianjin, China.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Amnesia/co [Complications]
+ Amyloid beta-Protein Precursor/bl [Blood]
+ Amyloid beta-Protein Precursor/ge [Genetics]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ China/ep [Epidemiology]
+ Cognitive Dysfunction/co [Complications]
+ *Cognitive Dysfunction/ge [Genetics]
+ Cyclic AMP Response Element-Binding Protein/bl [Blood]
+ Cyclic AMP Response Element-Binding Protein/ge [Genetics]
+ Female
+ *Gene Expression
+ Humans
+ Ideal Body Weight
+ LDL-Receptor Related Proteins/bl [Blood]
+ LDL-Receptor Related Proteins/ge [Genetics]
+ *Leukocytes, Mononuclear
+ Male
+ Membrane Transport Proteins/bl [Blood]
+ Membrane Transport Proteins/ge [Genetics]
+ Mental Status and Dementia Tests
+ Metabolic Syndrome/cl [Classification]
+ *Metabolic Syndrome/ge [Genetics]
+ Obesity/cl [Classification]
+ *Obesity/ge [Genetics]
+ *RNA, Messenger
+ Real-Time Polymerase Chain Reaction
+ Reverse Transcriptase Polymerase Chain Reaction
+ Synapsins/bl [Blood]
+ Synapsins/ge [Genetics]
+Keyword Heading
+ cognitive dysfunction
+ cognitive-related gene
+ metabolic syndrome
+ mild cognitive impairment
+ normal weight obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Obesity contributes to the development of mild cognitive impairment, but the potential role of normal weight obesity in this disease has not been explored in humans. The aim of the study was to reveal the relationship between normal weight obesity and mild cognitive impairment in elderly individuals.
+
+ METHODS: This study consisted of 360 patients with amnestic mild cognitive impairment and 360 cognitively normal controls. Normal weight obesity was defined as having metabolic syndrome but a normal weight. Metabolic health meant having no metabolic syndrome. Reverse transcription quantitative real-time polymerase chain reaction was adopted to measure the messenger RNA expression of four cognitive-related genes (amyloid precursor protein, cyclic adenosine monophosphate-responsive element-binding protein 1, sortilin-related receptor 1, and synapsin I) in peripheral blood mononuclear cells.
+
+ RESULTS: Normal weight obesity was related to a higher risk of amnestic mild cognitive impairment (odds ratio = 3.14, 95% confidence interval: 2.13-4.60). In the patients, the expression of each gene in the peripheral blood mononuclear cells was linearly related to Mini-Mental State Examination and Montreal Cognitive Assessment scores (P < 0.05). The expression of these genes in the patients with metabolic health deviated from the normal levels found in the controls (P < 0.05), and the deviations were more significant in the patients with normal weight obesity (P < 0.05).
+
+ CONCLUSION: Normal weight obesity may be a potential risk factor for amnestic mild cognitive impairment in elderly. This relationship was reflected in the abnormal expression of several cognitive-related genes in peripheral blood mononuclear cells. Copyright © 2019 Japanese Psychogeriatric Society.
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Protein Precursor). 0 (Biomarkers). 0 (Cyclic AMP Response Element-Binding Protein). 0 (LDL-Receptor Related Proteins). 0 (Membrane Transport Proteins). 0 (RNA, Messenger). 0 (SORL1 protein, human). 0 (SYN1 protein, human). 0 (Synapsins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fpsyg.12452
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1346-3500&title=Psychogeriatrics%3AThe+Official+Journal+of+the+Japanese+Psychogeriatric+Society&atitle=Relationship+between+normal+weight+obesity+and+mild+cognitive+impairment+is+reflected+in+cognitive-related+genes+in+human+peripheral+blood+mononuclear+cells.&volume=20&issue=1&spage=35&epage=43&date=2020&doi=10.1111%2Fpsyg.12452&pmid=30950168&sid=OVID:medline
+
+<1097>
+Unique Identifier
+ 30945727
+Title
+ The triglyceride-glucose index as a measure of insulin resistance and risk of obesity-related cancers.
+Source
+ International Journal of Epidemiology. 49(1):193-204, 2020 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fritz J; Bjorge T; Nagel G; Manjer J; Engeland A; Haggstrom C; Concin H; Teleka S; Tretli S; Gylling B; Lang A; Stattin P; Stocks T; Ulmer H
+Authors Full Name
+ Fritz, Josef; Bjorge, Tone; Nagel, Gabriele; Manjer, Jonas; Engeland, Anders; Haggstrom, Christel; Concin, Hans; Teleka, Stanley; Tretli, Steinar; Gylling, Bjorn; Lang, Alois; Stattin, Par; Stocks, Tanja; Ulmer, Hanno.
+Institution
+ Fritz, Josef. Department of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Innsbruck, Austria.
+ Bjorge, Tone. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
+ Bjorge, Tone. Cancer Registry of Norway, Oslo, Norway.
+ Nagel, Gabriele. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
+ Nagel, Gabriele. Agency for Preventive and Social Medicine, Bregenz (aks), Austria.
+ Manjer, Jonas. Department of Surgery, Skane University Hospital, Lund University, Malmo, Sweden.
+ Engeland, Anders. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
+ Engeland, Anders. Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway.
+ Haggstrom, Christel. Department of Biobank Research, Umea University, Umea, Sweden.
+ Haggstrom, Christel. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
+ Haggstrom, Christel. Department of Public Health and Clinical Medicine, Nutritional Research, Umea University, Umea, Sweden.
+ Concin, Hans. Agency for Preventive and Social Medicine, Bregenz (aks), Austria.
+ Teleka, Stanley. Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
+ Tretli, Steinar. Cancer Registry of Norway, Oslo, Norway.
+ Gylling, Bjorn. Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden.
+ Lang, Alois. Agency for Preventive and Social Medicine, Bregenz (aks), Austria.
+ Stattin, Par. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
+ Stocks, Tanja. Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
+ Ulmer, Hanno. Department of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Innsbruck, Austria.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Cohort Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ Glucose
+ Humans
+ Insulin Resistance
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Neoplasms/bl [Blood]
+ *Neoplasms/ep [Epidemiology]
+ *Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Risk Factors
+ Triglycerides/bl [Blood]
+Keyword Heading
+ Obesity
+ cancer
+ insulin resistance
+ longitudinal study
+ mediation analysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The role of insulin resistance as a mediator in the association of body mass index (BMI) with site-specific cancer risk has, to our knowledge, never been systematically quantified.
+
+ METHODS: Altogether 510 471 individuals from six European cohorts, with a mean age of 43.1 years, were included. We used the triglyceride glucose product (TyG index) as a surrogate measure for insulin resistance. We fitted Cox models, adjusted for relevant confounders, to investigate associations of TyG index with 10 common obesity-related cancers, and quantified the proportion of the effect of BMI mediated through TyG index on the log-transformed hazard ratio (HR) scale.
+
+ RESULTS: During a median follow-up of 17.2 years, 16 052 individuals developed obesity-related cancers. TyG index was associated with the risk of cancers of the kidney HR per one standard deviation increase 1.13, 95% confidence interval: 1.07 to 1.20], liver (1.13, 1.04 to 1.23), pancreas (1.12, 1.06 to 1.19), colon (1.07, 1.03 to 1.10) and rectum (1.09, 1.04 to 1.14). Substantial proportions of the effect of BMI were mediated by TyG index for cancers of the pancreas (42%), rectum (34%) and colon (20%); smaller proportions for kidney (15%) and liver (11%). Little or no mediation was observed for breast (postmenopausal), endometrial and ovarian cancer. Results were similar for males and females, except for pancreatic cancer where the proportions mediated were 20% and 91%, respectively.
+
+ CONCLUSIONS: The TyG index was associated with increased risk of cancers of the digestive system and substantially mediated the effect of BMI, suggesting that insulin resistance plays a promoting role in the pathogenesis of gastrointestinal cancers. Copyright © The Author(s) 2019; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1093%2fije%2fdyz053
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fritz&issn=0300-5771&title=International+Journal+of+Epidemiology&atitle=The+triglyceride-glucose+index+as+a+measure+of+insulin+resistance+and+risk+of+obesity-related+cancers.&volume=49&issue=1&spage=193&epage=204&date=2020&doi=10.1093%2Fije%2Fdyz053&pmid=30945727&sid=OVID:medline
+
+<1098>
+Unique Identifier
+ 30877567
+Title
+ Clinical follow-up on weight loss, glycemic control, and safety aspects of 24 months of duodenal-jejunal bypass liner implantation.
+Source
+ Surgical Endoscopy. 34(1):209-215, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Betzel B; Cooiman MI; Aarts EO; Janssen IMC; Wahab PJ; Groenen MJM; Drenth JPH; Berends FJ
+Author NameID
+ Betzel, B; ORCID: https://orcid.org/0000-0003-0593-8375
+Authors Full Name
+ Betzel, B; Cooiman, M I; Aarts, E O; Janssen, I M C; Wahab, P J; Groenen, M J M; Drenth, J P H; Berends, F J.
+Institution
+ Betzel, B. Department of Gastroenterology and Hepatology, Radboud University Medical Center, P.O. Box 9101, Code 455, 6500 HB, Nijmegen, The Netherlands. Bark.Betzel@radboudumc.nl.
+ Cooiman, M I. Vitalys Clinic, Velp, The Netherlands.
+ Cooiman, M I. Department of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
+ Aarts, E O. Vitalys Clinic, Velp, The Netherlands.
+ Aarts, E O. Department of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
+ Janssen, I M C. Vitalys Clinic, Velp, The Netherlands.
+ Janssen, I M C. Department of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
+ Wahab, P J. Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, The Netherlands.
+ Groenen, M J M. Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, The Netherlands.
+ Drenth, J P H. Department of Gastroenterology and Hepatology, Radboud University Medical Center, P.O. Box 9101, Code 455, 6500 HB, Nijmegen, The Netherlands.
+ Berends, F J. Vitalys Clinic, Velp, The Netherlands.
+ Berends, F J. Department of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Bariatric Surgery/is [Instrumentation]
+ *Bariatric Surgery/mt [Methods]
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Device Removal
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/su [Surgery]
+ *Duodenum/su [Surgery]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ *Jejunum/su [Surgery]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/su [Surgery]
+ Patient Safety
+ Postoperative Complications/ep [Epidemiology]
+ Postoperative Complications/th [Therapy]
+ Prospective Studies
+ Prostheses and Implants/ae [Adverse Effects]
+ *Prostheses and Implants
+ Time Factors
+ Treatment Outcome
+ Weight Loss
+ Young Adult
+Keyword Heading
+ Adverse events
+ Diabetes mellitus
+ Duodenal-jejunal bypass liner
+ Endobarrier
+ Hepatic abscess
+ Migration
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The duodenal-jejunal bypass liner (DJBL) is an endoscopic device designed to induce weight loss and improve glycemic control. The liner is licensed for a maximum implant duration of 12 months. It might be hypothesized that extension of the dwelling time results in added value. The goals of our study were to determine weight change, change in glycemic control, and safety in patients with an intended 24 months of DJBL dwelling time.
+
+ METHODS: Patients were initially selected for a 12-month implantation period. When no physical complaints or adverse events (AEs) occurred, motivated patients who responded well were selected for extension of dwelling time to 24 months. Patients underwent a control endoscopy 12 months after implantation and visited the out-patient clinic every 3 months up to explantation. Patients agreed to remove the DJBL when complaints or AEs occurred that could not be treated conservatively.
+
+ RESULTS: Implantation was extended in 44 patients, and 24 (55%) patients completed the full 24 months. Twenty patients required early removal due to AEs. During dwelling time, body weight decreased significantly (15.9 kg; TBWL 14.6%). HbA1c decreased non-significantly (4.9 mmol/mol). The number of insulin users and daily dose of insulin both decreased significantly. At 24 months after removal, glycemic control had worsened, while body weight was still significantly lower compared to baseline. In total, 68% of the patients experienced at least one AE. Two patients developed a hepatic abscess.
+
+ CONCLUSIONS: DJBL treatment results in significant weight loss and improves glycemic control during implantation. The largest beneficial effects occur during the first 9-12 months after implantation. Extension of dwelling time to 24 months results only in stabilization of body weight and glycemic control. After explantation, weight improvements are maintained, but glycemic control worsens. As the cumulative risk of AEs increases with time, a maximal dwelling time of 12 months is advisable.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs00464-019-06752-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Betzel&issn=0930-2794&title=Surgical+Endoscopy&atitle=Clinical+follow-up+on+weight+loss%2C+glycemic+control%2C+and+safety+aspects+of+24+months+of+duodenal-jejunal+bypass+liner+implantation.&volume=34&issue=1&spage=209&epage=215&date=2020&doi=10.1007%2Fs00464-019-06752-8&pmid=30877567&sid=OVID:medline
+
+<1099>
+Unique Identifier
+ 30739501
+Title
+ Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats.
+Source
+ Archives of Physiology & Biochemistry. 126(5):453-462, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Uddandrao VVS; Rameshreddy P; Brahmanaidu P; Ponnusamy P; Balakrishnan S; Ramavat RN; Swapna K; Pothani S; Nemani H; Meriga B; Vadivukkarasi S; P R N; Ganapathy S
+Authors Full Name
+ Uddandrao, V V Sathibabu; Rameshreddy, P; Brahmanaidu, P; Ponnusamy, Ponmurugan; Balakrishnan, Santhanaraj; Ramavat, Ravindar Naik; Swapna, K; Pothani, Suresh; Nemani, Harishankar; Meriga, Balaji; Vadivukkarasi, S; P R, Nivedha; Ganapathy, Saravanan.
+Institution
+ Uddandrao, V V Sathibabu. Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, India.
+ Rameshreddy, P. Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, India.
+ Brahmanaidu, P. Animal Physiology and Biochemistry Laboratory, ICMR-National Animal Resource Facility for Biomedical Research, Hyderabad, India.
+ Ponnusamy, Ponmurugan. Department of Botany, Bharathiar University, Coimbatore, India.
+ Balakrishnan, Santhanaraj. College of Applied Medical Sciences, Majmaah University, Al Majmaah, The Kingdom of Saudi Arabia.
+ Balakrishnan, Santhanaraj. Department of Bio-Medical Engineering, Velalar College of Engineering and Technology, Thindal, Tamil Nadu, India.
+ Ramavat, Ravindar Naik. Animal Physiology and Biochemistry Laboratory, ICMR-National Animal Resource Facility for Biomedical Research, Hyderabad, India.
+ Swapna, K. Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, India.
+ Pothani, Suresh. Animal Physiology and Biochemistry Laboratory, ICMR-National Animal Resource Facility for Biomedical Research, Hyderabad, India.
+ Nemani, Harishankar. Animal Physiology and Biochemistry Laboratory, ICMR-National Animal Resource Facility for Biomedical Research, Hyderabad, India.
+ Meriga, Balaji. Department of Biochemistry, Animal Physiology and Biochemistry Laboratory, Sri Venkateswara University, Tirupati, India.
+ Vadivukkarasi, S. Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, India.
+ P R, Nivedha. Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, India.
+ Ganapathy, Saravanan. Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, India.
+MeSH Subject Headings
+ *Adipogenesis
+ Animals
+ *Biomarkers/me [Metabolism]
+ *Diet, High-Fat
+ *Inflammation/dt [Drug Therapy]
+ Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ Lipid Metabolism
+ Male
+ *Obesity/co [Complications]
+ *Pentacyclic Triterpenes/pd [Pharmacology]
+ Rats
+ Rats, Sprague-Dawley
+Keyword Heading
+ High fat diet
+ asiatic acid
+ metabolic disorders
+ obesity; Centella asiatica
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In the current study, we evaluated the effects of Asiatic acid (AA) on lipid metabolic markers in HFD-induced obese Sprague-Dawley rat model. AA (20 mg/kg BW) was administered orally to HFD-fed rats for 42 days. Changes in body composition, glucose, insulin resistance (IR) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its target genes fatty-acid synthase (FAS), adipocyte protein-2 (aP2) and uncoupling protein-2 (UCP-2) and pro-inflammatory factor tumor necrosis factor (TNF)-alpha were observed in experimental rats. Oral administration of AA exerts therapeutic effects similar to orlistat in attenuating body weight gain, glucose, IR, plasma and tissue lipids and mRNA levels of PPAR-gamma, FAS, aP2 and inflammatory factor TNF-alpha and increasing UCP-2 expression in HFD-fed rats. Hence, these findings concluded that AA attenuate HFD-induced obesity by modulating PPAR-gamma and its target genes and regulate lipid metabolism, suggesting their possible antiobesity effects.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Pentacyclic Triterpenes). 9PA5A687X5 (asiatic acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f13813455.2018.1555668
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Uddandrao&issn=1381-3455&title=Archives+of+Physiology+%26+Biochemistry&atitle=Antiobesity+efficacy+of+asiatic+acid%3A+down-regulation+of+adipogenic+and+inflammatory+processes+in+high+fat+diet+induced+obese+rats.&volume=126&issue=5&spage=453&epage=462&date=2020&doi=10.1080%2F13813455.2018.1555668&pmid=30739501&sid=OVID:medline
+
+<1100>
+Unique Identifier
+ 30632794
+Title
+ Higher levels of IL-18 in patients with prediabetes compared to obese normoglycaemic controls.
+Source
+ Archives of Physiology & Biochemistry. 126(5):449-452, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gateva A; Kamenov Z; Karamfilova V; Assyov Y; Velikova T; El-Darawish Y; Okamura H
+Authors Full Name
+ Gateva, Antoaneta; Kamenov, Zdravko; Karamfilova, Vera; Assyov, Yavor; Velikova, Tsvetelina; El-Darawish, Yosif; Okamura, Haruki.
+Institution
+ Gateva, Antoaneta. Department of Internal Medicine, Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.
+ Kamenov, Zdravko. Department of Internal Medicine, Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.
+ Karamfilova, Vera. Department of Internal Medicine, Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.
+ Assyov, Yavor. Department of Internal Medicine, Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.
+ Velikova, Tsvetelina. Department of Clinical Immunology, University Hospital Lozenetz, Sofia, Bulgaria.
+ El-Darawish, Yosif. Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Tokyo, Japan.
+ Okamura, Haruki. Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Tokyo, Japan.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ Glucose Intolerance/bl [Blood]
+ *Glucose Intolerance/pa [Pathology]
+ Humans
+ *Interleukin-18/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/pa [Pathology]
+ Prediabetic State/bl [Blood]
+ *Prediabetic State/pa [Pathology]
+ Prognosis
+Keyword Heading
+ IL-18
+ obesity
+ prediabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Overweight and obesity are linked to low-grade chronic inflammation that can impair normal insulin function and induce insulin resistance. The aim of this study was to compare IL-18 levels between patients with prediabetes and obese normoglycaemic controls. Patients and methods: In this study, we included 131 patients with mean age 54.9 +/- 9.1 years, divided into two groups - group 1 with obesity without glycaemic disturbances (n = 66) and group 2 with prediabetes (n = 65). IL-18 was measured using enzyme-linked immunosorbent assay (ELISA) method. Results: Patients with prediabetes had significantly higher levels of IL-18 compared to obese controls (304.0 +/- 220.4 vs. 233.6 +/- 103.6 pg/l, p=.029). When patients with prediabetes were divided into IFG only, IGT only and IFG + IGT the highest levels of IL-18 were found in IGT only patients. Conclusions: Patients with prediabetes have higher levels of IL18 compared to obese normoglycemic controls.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (IL18 protein, human). 0 (Interleukin-18).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f13813455.2018.1555667
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gateva&issn=1381-3455&title=Archives+of+Physiology+%26+Biochemistry&atitle=Higher+levels+of+IL-18+in+patients+with+prediabetes+compared+to+obese+normoglycaemic+controls.&volume=126&issue=5&spage=449&epage=452&date=2020&doi=10.1080%2F13813455.2018.1555667&pmid=30632794&sid=OVID:medline
+
+<1101>
+Unique Identifier
+ 30572749
+Title
+ Adipokine profiles in preeclampsia.
+Source
+ Journal of Maternal-Fetal & Neonatal Medicine. 33(16):2812-2817, 2020 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chandrasekaran S; Hunt H; Melhorn S; Gammill HS; Schur EA
+Authors Full Name
+ Chandrasekaran, Suchitra; Hunt, Hayley; Melhorn, Susan; Gammill, Hilary S; Schur, Ellen A.
+Institution
+ Chandrasekaran, Suchitra. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Washington, Seattle, WA, USA.
+ Hunt, Hayley. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Washington, Seattle, WA, USA.
+ Melhorn, Susan. Department of Medicine, University of Washington, Seattle, WA, USA.
+ Gammill, Hilary S. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Washington, Seattle, WA, USA.
+ Gammill, Hilary S. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
+ Schur, Ellen A. Department of Medicine, University of Washington, Seattle, WA, USA.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ Female
+ Humans
+ Intra-Abdominal Fat/me [Metabolism]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Pre-Eclampsia/bl [Blood]
+ Pregnancy
+ Risk Factors
+Keyword Heading
+ Obesity
+ preeclampsia
+ visceral fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objectives: Hypertensive disorders of pregnancy (HDP), including preeclampsia (PE), are associated with short- and long-term maternal health complications, and obesity is a leading attributable risk factor for HDP. Yet, most women identified as obese [by body mass index (BMI) >= 30 kg/m2] do not develop HDP, indicating limited predictability of BMI alone. In nonpregnant populations, increased visceral fat mass (VFM) is an obesity-associated phenotype increasing the risk of developing hypertension. We sought to assess whether, in pregnancy, obese women with PE would have higher circulating levels of adipokines preferential to VFM compared to obese women without PE. Study Design: We performed a case-control study of women with and without PE, including obese (n = 65; BMI >= 30 kg/m2) and normal weight (n = 52; BMI 18.4-24.9 kg/m2) women. Plasma concentrations of adipokines preferential to VFM (visfatin, resistin), adipokines reflecting overall adiposity (leptin, adiponectin), and inflammatory cytokines were compared. Results: We found that among obese women, cases had significantly higher levels of VFM-associated adipokines and cytokines compared to controls [visfatin (p < .01, t = -3.8), resistin (p = .002, t = 1.12), IFN gamma (p = .04, t = -2.0), IL-6 (p < .01, t = -2.65), IL1-beta (p < .01, t = -4.1), IL-2 (p < .01, t = -3.9)]. Interestingly, however, obese and normal weight cases had similar VFM-adipokine and cytokine levels [visfatin (p = .34, t = -0.35), resistin (p = .55, t = -0.25)], and inflammatory marker concentrations [IFN gamma (p = .86, t = -0.76), IL-6 (p = .91, t = -0.53), IL-1beta (p = .67, t = 1.18), and IL-2 (p = .45, t = -1.16)]. These data possibly suggest an association between VFM and PE that is present independent of BMI. Conclusion: In summary, we demonstrated that, in normal-weight and obese women, PE was associated with higher concentrations of VFM-preferential adipokines compared to normal-weight and obese controls without PE.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f14767058.2018.1562542
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chandrasekaran&issn=1476-4954&title=Journal+of+Maternal-Fetal+%26+Neonatal+Medicine&atitle=Adipokine+profiles+in+preeclampsia.&volume=33&issue=16&spage=2812&epage=2817&date=2020&doi=10.1080%2F14767058.2018.1562542&pmid=30572749&sid=OVID:medline
+
+<1102>
+Unique Identifier
+ 30450993
+Title
+ Insulin resistance and oxidative marker in women with PCOS.
+Source
+ Archives of Physiology & Biochemistry. 126(2):183-186, 2020 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bannigida DM; Nayak BS; Vijayaraghavan R
+Authors Full Name
+ Bannigida, Doddappa M; Nayak, B Shivananda; Vijayaraghavan, R.
+Institution
+ Bannigida, Doddappa M. Department of Biochemistry, Koppal Institute of Medical Sciences, Koppal, India.
+ Bannigida, Doddappa M. Department of Research, Saveetha University, Thandalam, India.
+ Nayak, B Shivananda. Faculty of Medical Sciences, Department of preclinical Sciences, The University of the West Indies, Trinidad.
+ Nayak, B Shivananda. Department of Biochemistry, Subbaiah Institute of Medical sciences, Shimoga, India.
+ Vijayaraghavan, R. Department of Research, Saveetha University, Thandalam, India.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ *C-Reactive Protein/me [Metabolism]
+ Case-Control Studies
+ Fasting/bl [Blood]
+ Female
+ Humans
+ *Hyperinsulinism/bl [Blood]
+ Hyperinsulinism/di [Diagnosis]
+ Hyperinsulinism/pa [Pathology]
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ *Malondialdehyde/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pa [Pathology]
+ Ovary/me [Metabolism]
+ Ovary/pa [Pathology]
+ Oxidative Stress
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ Polycystic Ovary Syndrome/pa [Pathology]
+ Risk Factors
+Keyword Heading
+ CRP and MDA
+ Polycystic ovarian syndrome
+ hyperinsulinemia
+ insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Polycystic Ovary Syndrome is a multifactorial reproductive problem and a leading cause of female infertility worldwide. Evidences have shown that Oxidative Stress and decreased antioxidant status are often linked with PCOS. Insulin Resistance in PCOS patients ranges from 50% to 70% and may encourage OS by production of reactive oxygen species. Objective: Our study determines serum MDA levels along with plasma glucose, serum insulin, and insulin resistance in obese and nonobese PCOS subjects. Materials and methods: A case control study was conducted on diagnosed 100 PCOS patients and 100 controls. Fasting plasma glucose was measured by enzymatic method. Insulin was estimated by chemiluminescent microparticle immunoassay using Abott Architect i 2000 SR analyser. Insulin resistance was calculated by HOMA-IR. Malonaldehyde is determined as Thiobarbituric acid reactive substances. Results: CRP and serum MDA levels were increased in women with PCOS irrespective of obesity compared to their respective controls with a p value of < .001. However, though fasting glucose, serum insulin, and IR were increased in both obese and nonobese women with PCOS compared to their BMI adjusted controls with p value of < .001, the values were within reference range in nonobese women. Conclusion: Our study suggests that women with PCOS have oxidative stress and elevated CRP irrespective of obesity. However, hyperinsulinemia and Insulin resistance are seen only in obese women with PCOS, indicating that these women are at high risk for developing low grade inflammation and cardiovascular diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 4Y8F71G49Q (Malondialdehyde). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f13813455.2018.1499120
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bannigida&issn=1381-3455&title=Archives+of+Physiology+%26+Biochemistry&atitle=Insulin+resistance+and+oxidative+marker+in+women+with+PCOS.&volume=126&issue=2&spage=183&epage=186&date=2020&doi=10.1080%2F13813455.2018.1499120&pmid=30450993&sid=OVID:medline
+
+<1103>
+Unique Identifier
+ 30318936
+Title
+ Serum visfatin and adiponectin - markers in women with polycystic ovarian syndrome.
+Source
+ Archives of Physiology & Biochemistry. 126(4):283-286, 2020 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bannigida DM; Nayak SB; R V
+Authors Full Name
+ Bannigida, Doddappa Mallappa; Nayak, Shivananda B; R, Vijayaragavan.
+Institution
+ Bannigida, Doddappa Mallappa. Department of Biochemistry, Koppal Institute of Medical Sciences, Koppal, Karnataka, India.
+ Bannigida, Doddappa Mallappa. Department of Research, Saveetha University, Chennai, Tamil Nadu, India.
+ Nayak, Shivananda B. Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Trinidad, Trinidad and Tobago.
+ Nayak, Shivananda B. Department of Biochemistry, Subbaiah Institute of Medical Sciences, Shimoga, Karnataka, India.
+ R, Vijayaragavan. Department of Research, Saveetha University, Chennai, Tamil Nadu, India.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Case-Control Studies
+ Fasting/bl [Blood]
+ Female
+ Humans
+ Middle Aged
+ *Nicotinamide Phosphoribosyltransferase/bl [Blood]
+ Obesity/co [Complications]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/co [Complications]
+Keyword Heading
+ Polycystic ovarian syndrome
+ insulin resistance
+ visfatin and adiponectin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aim: Polycystic ovary syndrome (PCOS) is a leading cause of female infertility. Adipose tissue releases various adipokines, including visfatin and adiponectin, which have influence on insulin resistance (IR). Objective: To determine serum insulin levels, IR, serum visfatin and adiponectin levels in PCOS subjects. Materials and methods: Case-control study on 100 diagnosed PCOS patients (50 obese and 50 non-obese) and 100 control subjects (50 obese and 50 non obese). Investigations included serum measurement of insulin, visfatin and adiponectin using an enzyme-linked immunosorbant assay and Sinbe magnum technique. Results: There were higher levels of serum fasting glucose levels, serum insulin levels, IR and visfatin levels and lower levels of adiponectin in women with PCOS irrespective of body mass index, compared to their respective controls with a p value of < 0.001. Conclusion: The study suggests that serum visfatin levels positively correlate and serum adiponectin levels negatively correlate to insulin and IR in women with PCOS irrespective of obesity. Hence they can serve as markers in women with PCOS.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Blood Glucose). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f13813455.2018.1518987
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bannigida&issn=1381-3455&title=Archives+of+Physiology+%26+Biochemistry&atitle=Serum+visfatin+and+adiponectin+-+markers+in+women+with+polycystic+ovarian+syndrome.&volume=126&issue=4&spage=283&epage=286&date=2020&doi=10.1080%2F13813455.2018.1518987&pmid=30318936&sid=OVID:medline
+
+<1104>
+Unique Identifier
+ 29855190
+Title
+ Rapid Progression of Knee Pain and Osteoarthritis Biomarkers Greatest for Patients with Combined Obesity and Depression: Data from the Osteoarthritis Initiative.
+Source
+ Cartilage. 11(1):38-46, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jacobs CA; Vranceanu AM; Thompson KL; Lattermann C
+Authors Full Name
+ Jacobs, Cale A; Vranceanu, Ana-Maria; Thompson, Katherine L; Lattermann, Christian.
+Institution
+ Jacobs, Cale A. Department of Orthopedic Surgery and Sports Medicine, University of Kentucky, Lexington, KY, USA.
+ Vranceanu, Ana-Maria. Department of Psychology, Harvard Medical School and Integrated Brain Health Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
+ Thompson, Katherine L. Department of Statistics, University of Kentucky, Lexington, KY, USA.
+ Lattermann, Christian. Department of Orthopaedic Surgery, Harvard Medical School and Brigham and Women's Hospital, Chestnut Hill, MA, USA.
+MeSH Subject Headings
+ Arthralgia/co [Complications]
+ *Arthralgia/ur [Urine]
+ Biomarkers/ur [Urine]
+ Body Mass Index
+ *Collagen Type I/ur [Urine]
+ *Collagen Type II/ur [Urine]
+ Comorbidity
+ Depression/co [Complications]
+ Depression/ur [Urine]
+ Disease Progression
+ Female
+ Humans
+ Knee Joint/dg [Diagnostic Imaging]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity/ur [Urine]
+ Osteoarthritis, Knee/co [Complications]
+ Osteoarthritis, Knee/dg [Diagnostic Imaging]
+ *Osteoarthritis, Knee/ur [Urine]
+ Pain Measurement
+ *Peptide Fragments/ur [Urine]
+ *Peptides/ur [Urine]
+ Psychiatric Status Rating Scales
+ Radiography
+Keyword Heading
+ biomarker
+ depression
+ knee
+ obesity
+ osteoarthritis
+ pain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To compare the progression of biochemical biomarkers of osteoarthritis (OA), knee pain, and function between nonobese patients (NON), obese patients without depression (OBESE), and obese patients with comorbid depression (O + D).
+
+ DESIGN: Utilizing the FNIH OA Biomarkers Consortium dataset, we categorized knee OA patients into NON, OBESE, and O + D groups based on body mass index and Center for Epidemiological Studies-Depression (CES-D) scores. Subjective symptoms (Knee injury and Osteoarthritis Outcome Score Quality of Life subscale (KOOS QOL), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Physical Function scores, and the Short Form-12 (SF-12) Physical Component Score [PCS]) and objective measures of cartilage degradation and bone remodeling (urinary CTXII and CTXIalpha) were compared among groups at baseline and 2-year follow-up.
+
+ RESULTS: Of the 600 patients, 282 (47%) were NON, 285 (47.5%) OBESE, and 33 (5.5%) O + D. The O + D group had significantly worse pain and function both at baseline and 2-year follow-up (P < 0.001 for all comparisons) as evidenced by self-reported measures on KOOS QOL, WOMAC Pain, WOMAC Physical Function, and SF-12 PCS. The O + D group also demonstrated significant increases in CTXII (P = 0.01) and CTXIalpha (P = 0.005), whereas the NON and OBESE groups did not.
+
+ CONCLUSIONS: The combination of inferior knee pain, physical function, and significantly greater increases in biomarkers of cartilage degradation and bony remodelling suggest a more rapid progression for obese OA patients with comorbid depression. The link between systemic disease, inflammatory burden, and progressive cartilage degradation is in line with increasing concerns about a degenerative synovial environment in early osteoarthritic knees that progress to treatment failure with biologic restoration procedures.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C-terminal cross-linking telopeptide of type II collagen, human). 0 (Collagen Type I). 0 (Collagen Type II). 0 (Peptide Fragments). 0 (Peptides). 0 (collagen type I trimeric cross-linked peptide).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1177%2f1947603518777577
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jacobs&issn=1947-6035&title=Cartilage&atitle=Rapid+Progression+of+Knee+Pain+and+Osteoarthritis+Biomarkers+Greatest+for+Patients+with+Combined+Obesity+and+Depression%3A+Data+from+the+Osteoarthritis+Initiative.&volume=11&issue=1&spage=38&epage=46&date=2020&doi=10.1177%2F1947603518777577&pmid=29855190&sid=OVID:medline
+
+<1105>
+Unique Identifier
+ 33832885
+Title
+ An alternative approach to treat obesity with leptogenic polyherbal formulation obesecure: A randomized clinical trial study.
+Source
+ Pakistan Journal of Pharmaceutical Sciences. 33(5(Special)):2423-2430, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Riazurrehman M; Iqbal A; Ayaz S; Khurram H; Akhter N; Mahmood A; Akram M; Rashid A; Asif HM
+Authors Full Name
+ Riazurrehman, Muhammad; Iqbal, Asif; Ayaz, Sultan; Khurram, Haris; Akhter, Naheed; Mahmood, Arshad; Akram, Muhammad; Rashid, Abid; Asif, Hafiz Muhammad.
+Institution
+ Riazurrehman, Muhammad. Faculty of Eastern medicine, Hamdard University, Karachi, Pakistan.
+ Iqbal, Asif. Faculty of Eastern medicine, Hamdard University, Karachi, Pakistan.
+ Ayaz, Sultan. Directorate of Medical Sciences, GC University, Faisalabad, Pakistan.
+ Khurram, Haris. Department of Sciences and Humanities, National University of Computer and Emerging Sciences, Faisalabad, Pakistan.
+ Akhter, Naheed. Directorate of Medical Sciences, GC University, Faisalabad, Pakistan.
+ Mahmood, Arshad. Faculty of Science, Barret Hodgson University, Karachi, Pakistan.
+ Akram, Muhammad. Directorate of Medical Sciences, GC University, Faisalabad, Pakistan.
+ Rashid, Abid. Directorate of Medical Sciences, GC University, Faisalabad, Pakistan.
+ Asif, Hafiz Muhammad. College of Conventional Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
+MeSH Subject Headings
+ Adult
+ Anti-Obesity Agents/ae [Adverse Effects]
+ *Anti-Obesity Agents/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Double-Blind Method
+ Drugs, Chinese Herbal/ae [Adverse Effects]
+ *Drugs, Chinese Herbal/tu [Therapeutic Use]
+ Female
+ Humans
+ Leptin/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Pakistan
+ Prospective Studies
+ Time Factors
+ Treatment Outcome
+ *Weight Loss/de [Drug Effects]
+ Young Adult
+Abstract
+ Obesity is a common disease of developing countries, including Pakistan. Obesity is a risk factor for many diseases which can be life threatening or making the person unable to perform daily routine work. In the current study, clinical trials were designed to evaluate the effects of medical intervention by comparing the effects of placebo control drug "Plasicure" with the herbal medicinal formulation "Obesecure". The test drug formulation was designed on the basis of the screening study for Leptogenic drugs. To evaluate the safety of the test drug, the toxicity index and the safety profile of test formulation was assessed on animal models. The drug was found safe for further clinical study. Randomized Controlled Clinical Trials were conducted. The statistical analysis was carried out by the application of Two-Way Repeated Analysis of Variance test. The clinical findings of randomized controlled trial revealed that the test drug was Leptogenic and effective in weight reduction as compared to control drug Plasicure therapy as the p-value deduced was 0.001 in leptin level and 0.000 in case of BMI after the conduction of Two-Way Repeated Analysis of Variance test. Hence it is concluded that obscure therapy is more significant than control drug Plasicure therapy in the management and treatment of obesity.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Drugs, Chinese Herbal). 0 (LEP protein, human). 0 (Leptin).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&AN=33832885
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Riazurrehman&issn=1011-601X&title=Pakistan+Journal+of+Pharmaceutical+Sciences&atitle=An+alternative+approach+to+treat+obesity+with+leptogenic+polyherbal+formulation+obesecure%3A+A+randomized+clinical+trial+study.&volume=33&issue=5&spage=2423&epage=2430&date=2020&doi=&pmid=33832885&sid=OVID:medline
+
+<1106>
+Unique Identifier
+ 33612619
+Title
+ SIRT1 as a Potential Biomarker for Obesity.
+Source
+ Journal of Nutritional Science & Vitaminology. 66(Supplement):S324-S328, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Salim S; Kartawidjajaputra F; Suwanto A
+Authors Full Name
+ Salim, Stephen; Kartawidjajaputra, Felicia; Suwanto, Antonius.
+Institution
+ Salim, Stephen. Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia.
+ Kartawidjajaputra, Felicia. Nutrifood Research Center, PT Nutrifood Indonesia.
+ Suwanto, Antonius. Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Cross-Sectional Studies
+ Humans
+ Intra-Abdominal Fat
+ *Leukocytes, Mononuclear
+ Obesity
+ Sirtuin 1/ge [Genetics]
+ *Sirtuin 1
+Keyword Heading
+ BMI
+ SIRT1
+ fat consumption
+ obesity
+ visceral fat area
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Asian people generally have thin figures; yet, they often suffer from hidden alarming metabolic conditions due to high visceral fat area (VFA). Therefore, it is crucial to have a biomarker to predict visceral obesity to prevent further complications. SIRT1, a NAD-dependent deacetylase gene, is responsible for upregulating lipolysis genes and is downregulated after acute high-fat meal consumption. However, the chronic exposure effect remains unknown. The purpose of this study was to assess the association between SIRT1 mRNA expression, fat intake, and visceral obesity in Indonesian population.
+
+ METHODS: This cross-sectional study involved 38 healthy subjects (20-30 y old, not suffering any chronic diseases or fever, not taking any medication or treatment, not smoking, not drinking alcohol frequently, not being pregnant, and not breastfeeding). Dietary patterns from 24-h food recall, physical activities fom international physical activity questionnaire (IPAQ), medical data from annual medical check-up, and body compositions were measured using InBody720 and compared with SIRT1 expression from peripheral blood mononuclear cells (PBMCs) samples.
+
+ RESULTS: Subjects with excessive percentage of body fat (PBF) had a significantly higher body mass index (BMI) (normal: 20.28+/-2.09, excessive: 23.86+/-3.71, p=0.023) and VFA (normal: 48.00+/-9.38, excessive: 79.17+/-16.14, p=5x1025). The SIRT1 mRNA expression was significantly higher in subjects with excessive PBF (normal: 1+/-0.43, excessive: 3.68+/-2.62, p=0.018) and positively correlated with PBF (rho=0.376, p=0.045).
+
+ CONCLUSION: SIRT1 acted as a potential marker for obesity in the evaluated population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-5-1 (SIRT1 protein, human). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3177%2fjnsv.66.S324
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Salim&issn=0301-4800&title=Journal+of+Nutritional+Science+%26+Vitaminology&atitle=SIRT1+as+a+Potential+Biomarker+for+Obesity.&volume=66&issue=&spage=S324&epage=S328&date=2020&doi=10.3177%2Fjnsv.66.S324&pmid=33612619&sid=OVID:medline
+
+<1107>
+Unique Identifier
+ 33597945
+Title
+ The Important Role of Leptin in Modulating the Risk of Dermatological Diseases. [Review]
+Source
+ Frontiers in Immunology. 11:593564, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Su X; Cheng Y; Chang D
+Authors Full Name
+ Su, Xin; Cheng, Ye; Chang, Dong.
+Institution
+ Su, Xin. Department of Cardiology, The Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, China.
+ Cheng, Ye. Department of Cardiology, The Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, China.
+ Chang, Dong. Department of Cardiology, The Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, China.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Disease Susceptibility
+ Energy Metabolism
+ Gene Expression Regulation
+ Hair/me [Metabolism]
+ Hair Diseases/et [Etiology]
+ Hair Diseases/me [Metabolism]
+ Hair Diseases/pa [Pathology]
+ Humans
+ *Leptin/ge [Genetics]
+ *Leptin/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Organ Specificity
+ Reactive Oxygen Species/me [Metabolism]
+ *Skin Diseases/et [Etiology]
+ *Skin Diseases/me [Metabolism]
+ Skin Diseases/pa [Pathology]
+Keyword Heading
+ dermatological diseases
+ immune system
+ leptin
+ leptin receptor
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ It is an indisputable fact that obesity is associated with a series of health problems. One important hallmark of obesity is excessive accumulation of lipids in the adipocyte, especially triglyceride (TG). Currently, the adipocyte has been considered not only as a huge repository of excess energy in the form of fat but also as an important source of multiple hormones and cytokines called adipokines. In obesity, the adipocyte is dysfunctional with excessive production and secretion of pro-inflammatory adipokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and leptin. On the other hand, accumulating evidence has shown that leptin plays a vital role in stimulating angiogenesis, controlling lipid metabolism, and modulating the production of pro-inflammatory cytokines. Furthermore, the various activities of leptin are related to the wide distribution of leptin receptors. Notably, it has been reported that enhanced leptin levels and dysfunction of the leptin signaling pathway can influence diverse skin diseases. Recently, several studies revealed the roles of leptin in wound healing, the hair cycle, and the pathogenic development of skin diseases, such as psoriasis, lupus erythematosus, and dermatological cancers. However, the exact mechanisms of leptin in modulating the dermatological diseases are still under investigation. Therefore, in the present review, we summarized the regulatory roles of leptin in the pathological progression of diverse diseases of skin and skin appendages. Furthermore, we also provided evidence to elucidate the complicated relationship between leptin and different dermatological diseases, such as systemic lupus erythematosus (SLE), psoriasis, hidradenitis suppurativa, and some skin tumors. Copyright © 2021 Su, Cheng and Chang.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). 0 (Reactive Oxygen Species).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffimmu.2020.593564
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Su&issn=1664-3224&title=Frontiers+in+Immunology&atitle=The+Important+Role+of+Leptin+in+Modulating+the+Risk+of+Dermatological+Diseases.&volume=11&issue=&spage=593564&epage=&date=2020&doi=10.3389%2Ffimmu.2020.593564&pmid=33597945&sid=OVID:medline
+
+<1108>
+Unique Identifier
+ 33581705
+Title
+ Relationship of acanthosis nigricans with metabolic syndrome in obese children.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 33(12):1563-1568, 2020 Dec 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Daye M; Selver Eklioglu B; Atabek ME
+Author NameID
+ Selver Eklioglu, Beray; ORCID: https://orcid.org/0000-0002-6700-5346
+ Atabek, Mehmet Emre; ORCID: https://orcid.org/0000-0002-2242-9401
+Authors Full Name
+ Daye, Munise; Selver Eklioglu, Beray; Atabek, Mehmet Emre.
+Institution
+ Daye, Munise. Department of Dermatology, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
+ Selver Eklioglu, Beray. Necmettin Erbakan University Faculty of Medicine, Division of Pediatric Endocrinology, Konya, Turkey.
+ Atabek, Mehmet Emre. Necmettin Erbakan University Faculty of Medicine, Division of Pediatric Endocrinology, Konya, Turkey.
+MeSH Subject Headings
+ Acanthosis Nigricans/et [Etiology]
+ Acanthosis Nigricans/me [Metabolism]
+ *Acanthosis Nigricans/pa [Pathology]
+ Adolescent
+ *Biomarkers/me [Metabolism]
+ Child
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome/pa [Pathology]
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prognosis
+Keyword Heading
+ acanthosis nigricans
+ children
+ hyperglycemia
+ metabolic syndrome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Acanthosis nigricans is a skin symptom in obesity that helps to identify patients at high risk for dyslipidemia, hypertension, insulin resistance, and diabetes. It is the most important complication of obesity in metabolic syndrome. Studies investigating the relationship between acanthosis nigricans and metabolic syndrome in obese children are insufficient. In our study, the relationship of acanthosis nigricans and metabolic syndrome was evaluated in children.
+
+ METHODS: Obese children aged between 6 and 18 years old, who were examined in the pediatric endocrinology outpatient clinic, were included. The patients' anthropometric measurements and laboratory results were recorded. Modified IDF (International Diabetes Federation) criteria for children were used in metabolic syndrome classification.
+
+ RESULTS: A hundred and forty-eight obese children were evaluated. The mean age of the cases was 11.91 +/- 2.94 years old. Of the cases, 56.1% were female (n=83) 43.9% (n=65) were male. In 39.9% (n=59) of cases, acanthosis nigricans was determined. Acanthosis nigricans was mostly located in the axillary area (27.1%) and the neck (16.9%). In 55.9% of the cases, it was located in more than one area. The relation of regionally detected acanthosis nigricans and metabolic syndrome was not significant (p=0.291). Metabolic syndrome was detected in 14% of 136 patients according to IDF criteria. Acanthosis nigricans and metabolic syndrome combination was present in 27.7%; however, 6.7% of the metabolic syndrome patients did not have acanthosis nigricans. There was a strong relation between metabolic syndrome and the presence of acanthosis nigricans (p=0.003).
+
+ CONCLUSIONS: In our study, a correlation between acanthosis nigricans and metabolic syndrome was detected. Acanthosis nigricans is a skin sign that can be easily detected by clinician. It is an important and easy-to-detect dermatosis that helps determine patients at risk of metabolic syndrome in obese children. Copyright © 2020 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1515%2fjpem-2020-0154
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Daye&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Relationship+of+acanthosis+nigricans+with+metabolic+syndrome+in+obese+children.&volume=33&issue=12&spage=1563&epage=1568&date=2020&doi=10.1515%2Fjpem-2020-0154&pmid=33581705&sid=OVID:medline
+
+<1109>
+Unique Identifier
+ 33581704
+Title
+ Can we use copeptin as a biomarker for masked hypertension or metabolic syndrome in obese children and adolescents?.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 33(12):1551-1561, 2020 Dec 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Deligozoglu D; Kasap-Demir B; Alparslan C; Erbak H; Catli G; Mutlubas F; Alaygut D; Soyaltin E; Arslansoyu-Camlar S; Yavascan O
+Author NameID
+ Kasap-Demir, Belde; ORCID: https://orcid.org/0000-0002-5456-3509
+Authors Full Name
+ Deligozoglu, Duygu; Kasap-Demir, Belde; Alparslan, Caner; Erbak, Huriye; Catli, Gonul; Mutlubas, Fatma; Alaygut, Demet; Soyaltin, Eren; Arslansoyu-Camlar, Secil; Yavascan, Onder.
+Institution
+ Deligozoglu, Duygu. Department of Pediatrics, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Kasap-Demir, Belde. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Kasap-Demir, Belde. Department of Pediatrics, Division of Nephrology, Izmir Katip Celebi University, Izmir, Turkey.
+ Alparslan, Caner. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Erbak, Huriye. Department of Biochemistry, Izmir Katip Celebi University, Izmir, Turkey.
+ Catli, Gonul. Department of Pediatrics, Division of Endocrinology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Catli, Gonul. Department of Pediatrics, Division of Endocrinology, Izmir Katip Celebi University, Izmir, Turkey.
+ Mutlubas, Fatma. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Alaygut, Demet. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Soyaltin, Eren. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Arslansoyu-Camlar, Secil. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Yavascan, Onder. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
+ Yavascan, Onder. Department of Pediatrics, Division of Nephrology, Istanbul Medipol University, Istanbul, Turkey.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ Child
+ Female
+ Follow-Up Studies
+ *Glycopeptides/bl [Blood]
+ Humans
+ Male
+ Masked Hypertension/bl [Blood]
+ *Masked Hypertension/di [Diagnosis]
+ Masked Hypertension/et [Etiology]
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ *Obesity/co [Complications]
+ Prognosis
+ Prospective Studies
+Keyword Heading
+ children
+ copeptin
+ masked hypertension
+ metabolic syndrome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Copeptin, the C-terminal part of arginine-vasopressin, is increased in hypertensive adolescents and closely associated with metabolic syndrome (MS). We aimed to investigate whether serum copeptin can be used to differentiate masked hypertension (MHT) and MS, and the role of sodium intake, natriuretic peptide response and renin-angiotensin-aldosterone system in MHT and MS in obese youth.
+
+ METHODS: Obese children aged 10-18 years with normal office blood pressure measurements were included. Patients with MHT and normotension and those with MS and non-MS were evaluated separately. Biochemical parameters, copeptin, brain natriuretic peptide (BNP), aldosterone, renin, urine sodium, and protein were evaluated. Echocardiography, fundoscopic examination, and ambulatory blood pressure monitoring were performed.
+
+ RESULTS: There were 80 (M/F=39/41) obese patients with a mean age of 13.78 +/- 1.93 years. The cases with MHT, MS, and concomitant MHT and MS were 53,24, and 13%, respectively. Copeptin levels were similar among patients with and without MHT or MS (p>0.05). However, multivariate analysis revealed that copeptin significantly increased the probability of MHT (OR 1.01, 95% CI=1.001-1.018, p=0.033). Copeptin was positively correlated with daytime systolic and diastolic load, aldosterone, BNP, and urine microalbumin/creatinine levels (p<0.05). Linear regression analyses revealed that copeptin was significantly correlated with BNP regardless of having MHT or MS in obese youth. In the MHT group, 24-h sodium excretion was not significantly correlated with BNP.
+
+ CONCLUSION: Copeptin may be a beneficial biomarker to discriminate MHT, but not MS in obese children and adolescents. An insufficient BNP response to sodium intake might be one of the underlying causes of MHT in obese cases. Copyright © 2020 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycopeptides). 0 (copeptins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1515%2fjpem-2020-0240
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Deligozoglu&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Can+we+use+copeptin+as+a+biomarker+for+masked+hypertension+or+metabolic+syndrome+in+obese+children+and+adolescents%3F.&volume=33&issue=12&spage=1551&epage=1561&date=2020&doi=10.1515%2Fjpem-2020-0240&pmid=33581704&sid=OVID:medline
+
+<1110>
+Unique Identifier
+ 33581014
+Title
+ Greater effects of high- compared with moderate-intensity interval training on thyroid hormones in overweight/obese adolescent girls.
+Source
+ Hormone Molecular Biology & Clinical Investigation. 41(4), 2020 Nov 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abassi W; Ouerghi N; Ghouili H; Haouami S; Bouassida A
+Author NameID
+ Ouerghi, Nejmeddine; ORCID: https://orcid.org/0000-0002-8840-1735
+Authors Full Name
+ Abassi, Wissal; Ouerghi, Nejmeddine; Ghouili, Hatem; Haouami, Salma; Bouassida, Anissa.
+Institution
+ Abassi, Wissal. Research Unit, Sportive Performance and Physical Rehabilitation, High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia.
+ Abassi, Wissal. Higher Institute of Sport and Physical Education of Ksar Said, University of "La Manouba", Manouba, Tunisia.
+ Ouerghi, Nejmeddine. Research Unit, Sportive Performance and Physical Rehabilitation, High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia.
+ Ouerghi, Nejmeddine. University of Tunis El Manar, Faculty of Medicine of Tunis, Rabta Hospital, Tunis, Tunisia.
+ Ghouili, Hatem. Research Unit, Sportive Performance and Physical Rehabilitation, High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia.
+ Haouami, Salma. Research Unit, Sportive Performance and Physical Rehabilitation, High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia.
+ Bouassida, Anissa. Research Unit, Sportive Performance and Physical Rehabilitation, High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia.
+MeSH Subject Headings
+ Biomarkers
+ Blood Glucose
+ Body Mass Index
+ Exercise
+ Female
+ *High-Intensity Interval Training
+ Humans
+ *Obesity/bl [Blood]
+ *Overweight/bl [Blood]
+ *Physical Conditioning, Human
+ Sex Factors
+ *Thyroid Hormones/bl [Blood]
+Keyword Heading
+ insulin-resistance
+ intermittent training
+ thyroid stimulating hormone
+ thyroxine
+ training intensity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To investigate the effects of 12-week high-intensity- (HIIT) vs. moderate-intensity-interval training (MIIT) on thyroid stimulating hormone (TSH) and thyroxine (T4) and insulin-resistance in overweight/obese adolescent girls.
+
+ METHODS: Twenty four adolescent girls (age 16.5+/-1.36 yrs) were randomly allocated into three groups: (1) HIIT (2 blocks per session of 6-8 bouts of 30 s runs at 100-110% maximal aerobic speed (MAS), with 30 s active recovery between bouts at 50% MAS; n=8), (2) MIIT (2 blocks per session of 6-8 bouts of 30 s runs at 70-80% MAS, with 30 s active recovery between bouts at 50% MAS; n=8) and (3) control group (no exercise, n=8). Each training groups engaged in three sessions per week during three months. Anthropometric parameters, aerobic capacity, homeostasis model assessment index for insulin resistance (HOMA-IR) as well as plasma TSH and T4 levels were assessed in all subjects before- and after-training.
+
+ RESULTS: Following both training programs, body mass, body mass index Z-score, waist circumference and body fat decreased, while aerobic capacity increased. However, TSH and T4 concentrations decreased only after the HIIT (-30.47%, p<0.05, ES=1.42 and -12.86%, p<0.05, ES=1.18; respectively). The HOMA-IR decreased in both training groups (-26.25%, p<0.05, ES=1.87 for MIIT and -21.72%, p<0.05, ES=2.14 for HIIT).
+
+ CONCLUSION: Twelve weeks of HIIT was effective in reducing circulating TSH and T4 levels, unlike MIIT, in overweight/obese adolescent girls. These findings indicated that the stimulation of pituitary-thyroid function is more sensitive to training intensity than training duration. Further studies are needed to confirm this conclusion. Copyright © 2020 Walter de Gruyter GmbH, Berlin/Boston.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Thyroid Hormones).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1515%2fhmbci-2020-0031
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abassi&issn=1868-1883&title=Hormone+Molecular+Biology+%26+Clinical+Investigation&atitle=Greater+effects+of+high-+compared+with+moderate-intensity+interval+training+on+thyroid+hormones+in+overweight%2Fobese+adolescent+girls.&volume=41&issue=4&spage=&epage=&date=2020&doi=10.1515%2Fhmbci-2020-0031&pmid=33581014&sid=OVID:medline
+
+<1111>
+Unique Identifier
+ 33540406
+Title
+ Anthropometric Evaluation and Assessment of Food Intake of Parents of Pediatric Patients with Chronic Rheumatic Diseases.
+Source
+ Annals of Nutrition & Metabolism. 76(6):387-395, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pereira L; Previdelli AN; Rossi RGT; Rodrigues WD; Fonseca FLA; Len CA; Terreri MT; Saccardo Sarni RO
+Authors Full Name
+ Pereira, Lucila; Previdelli, Agatha Nogueira; Rossi, Rosana Gomes de Torres; Rodrigues, Wellington Douglas; Fonseca, Fernando Luiz Affonso; Len, Claudio Arnaldo; Terreri, Maria Teresa; Saccardo Sarni, Roseli Oselka.
+Institution
+ Pereira, Lucila. Department of Pediatrics, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
+ Previdelli, Agatha Nogueira. Health Sciences, USP School of Public Health, Sao Paulo, Brazil.
+ Previdelli, Agatha Nogueira. Aging Sciences, Sao Judas University, Sao Paulo, Brazil.
+ Rossi, Rosana Gomes de Torres. Nutrition and Metabolism, ABC Foundation School of Medicine, Sao Paulo, Brazil.
+ Rossi, Rosana Gomes de Torres. Sao Judas University, Sao Paulo, Brazil.
+ Rodrigues, Wellington Douglas. Pediatrics Nutrition and Pediatrics Applied Sciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
+ Rodrigues, Wellington Douglas. University of the United Metropolitan Faculties, Sao Paulo, Brazil.
+ Fonseca, Fernando Luiz Affonso. Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
+ Len, Claudio Arnaldo. Department of Pediatrics, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
+ Terreri, Maria Teresa. Department of Pediatrics, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
+ Saccardo Sarni, Roseli Oselka. Department of Pediatrics, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil, rssarni@gmail.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Anthropometry
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Child
+ Chronic Disease
+ Cross-Sectional Studies
+ *Diet/sn [Statistics & Numerical Data]
+ Diet Surveys
+ Dietary Fats/an [Analysis]
+ Dyslipidemias/ep [Epidemiology]
+ Eating
+ Exercise
+ *Feeding Behavior
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ *Parents
+ *Rheumatic Diseases
+Keyword Heading
+ Dermatomyositis
+ Food consumption
+ Juvenile idiopathic arthritis
+ Rheumatic diseases
+ Systemic lupus erythematosus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Parents' eating behavior, lifestyle, and food choices can interfere with their children's eating habits, bringing new perspectives for the development of beneficial interventions in the context of chronic rheumatic diseases.
+
+ OBJECTIVES: The objective is to evaluate BMI, dietary intake, physical activity, and biomarkers of lipid metabolism in parents of children and adolescents with chronic rheumatic diseases and to verify the association with those of their children.
+
+ METHODS: This is a cross-sectional study with 91 parents, and their respective children diagnosed with juvenile idiopathic arthritis (n = 30, 33.0%), juvenile systemic lupus erythematosus (n = 41, 45.0%), and juvenile dermatomyositis (n = 20, 22.0%). Anthropometric and dietary data, physical activity, lipid profile, and apolipoproteins A-I and B were evaluated.
+
+ RESULTS: In total, 67% of parents and 27.5% of children were overweight; 80% of overweight children/adolescents also had parents with the same nutritional diagnosis. We found a moderate association of total fat intake (Cramer's V test = 0.254; p = 0.037), and a weak association of saturated fat intake (Cramer's V test = 0.219; p = 0.050) and cholesterol intake (Cramer's V test = 0.234; p = 0.025) between parents and their children. A high prevalence of dyslipidemia was observed for parents (82.4%) and children (83.5%), however, with no association between both. A weak association was found between parents and children (Cramer's V test = 0.238; p = 0.024) for triglycerides, and no association was found between parents and children concerning physical activity.
+
+ CONCLUSION: The high frequency of overweight and dyslipidemia observed in parents, combined with the association between the fat intake by parents and their children with chronic rheumatic diseases, points to the importance of intervention strategies with the engagement and participation of families. Copyright © 2021 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fats).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1159%2f000512243
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pereira&issn=0250-6807&title=Annals+of+Nutrition+%26+Metabolism&atitle=Anthropometric+Evaluation+and+Assessment+of+Food+Intake+of+Parents+of+Pediatric+Patients+with+Chronic+Rheumatic+Diseases.&volume=76&issue=6&spage=387&epage=395&date=2020&doi=10.1159%2F000512243&pmid=33540406&sid=OVID:medline
+
+<1112>
+Unique Identifier
+ 33408265
+Title
+ The importance of laboratory tests and Body Mass Index in the diagnosis of acute appendicitis.
+Source
+ Polski Przeglad Chirurgiczny. 92(6):7-11, 2020 Aug 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ozkan A; Gokce AH; Gokce FS
+Authors Full Name
+ Ozkan, Atakan; Gokce, Aylin Hande; Gokce, Feridun Suat.
+Institution
+ Ozkan, Atakan. Atlas University Medical Faculty General Surgeon, Istanbul, Turkey.
+ Gokce, Aylin Hande. Atlas University Medical Faculty General Surgeon, Istanbul, Turkey.
+ Gokce, Feridun Suat. Balikli Rum Hospital, General Surgery, Istanbul, Turkey.
+MeSH Subject Headings
+ Adult
+ Appendectomy
+ *Appendicitis/bl [Blood]
+ *Appendicitis/di [Diagnosis]
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Case-Control Studies
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Retrospective Studies
+Keyword Heading
+ acute abdomen
+ acute appendicitis
+ appendectomy
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Acute appendicitis is the most common cause of acute abdomen. Delay in diagnosis increases the mortality and morbidity.
+Aim: In this study, we aimed to investigate whether the body mass index is useful in diagnosis and whether the neutrophil /lymphocyte and platelet/lymphocyte ratios can help in determining the inflammation level of acute appendicitis.
+Meterial and Methods: Cases of appendectomy performed between June 2012 and December 2018 in our clinic were analyzed retrospectively. Based on the pathology results of the cases included in the study, 4 groups were formed, i.e.: Group 1 (initial stage), Group 2 (catarrhal stage), Group 3 (phlegmonous-gangrenous stage) and Group 4 (perforation). The study compared age, body mass index, leukocyte values, red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), platelet /lymphocyte ratio (PLR), and mean platelet volume (MPV) between groups.
+ Results: 828 cases were included in the study. When compared between groups, the values of Group 3 and Group 4 were higher than those of Group 1 and Group 2 for PLR and NLR. There was no difference in RDW and MPV values in the blood. When Body Mass Index (BMI) was compared between groups, it was found to be significantly higher with increasing histopathological stage.
+Conclusion: In acute appendicitis, the blood leukocyte value, elevated PLR and NLR are helpful in diagnosis. We aimed to emphasize that the diagnosis of acute appendicitis is delayed in patients with a BMI above 30 and/or at age of over 40 years, with the perforation rate being determined more frequently.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.5604%2f01.3001.0014.3579
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ozkan&issn=0032-373X&title=Polski+Przeglad+Chirurgiczny&atitle=The+importance+of+laboratory+tests+and+Body+Mass+Index+in+the+diagnosis+of+acute+appendicitis.&volume=92&issue=6&spage=7&epage=11&date=2020&doi=10.5604%2F01.3001.0014.3579&pmid=33408265&sid=OVID:medline
+
+<1113>
+Unique Identifier
+ 33381605
+Title
+ Obesity Potentiates Esophageal Squamous Cell Carcinoma Growth and Invasion by AMPK-YAP Pathway.
+Source
+ Journal of Immunological Research. 2020:6765474, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu JH; Wu QF; Fu JK; Che XM; Li HJ
+Author NameID
+ Liu, Jia-Huang; ORCID: https://orcid.org/0000-0002-9475-9899
+ Wu, Qi-Fei; ORCID: https://orcid.org/0000-0002-7439-2831
+ Fu, Jun-Ke; ORCID: https://orcid.org/0000-0001-9286-1446
+ Che, Xiang-Ming; ORCID: https://orcid.org/0000-0002-3730-7802
+ Li, Hai-Jun; ORCID: https://orcid.org/0000-0002-6040-6956
+Authors Full Name
+ Liu, Jia-Huang; Wu, Qi-Fei; Fu, Jun-Ke; Che, Xiang-Ming; Li, Hai-Jun.
+Institution
+ Liu, Jia-Huang. Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
+ Liu, Jia-Huang. Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
+ Wu, Qi-Fei. Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
+ Fu, Jun-Ke. Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
+ Che, Xiang-Ming. Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
+ Li, Hai-Jun. Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
+MeSH Subject Headings
+ *AMP-Activated Protein Kinases/me [Metabolism]
+ Adipokines/me [Metabolism]
+ Animals
+ Biomarkers
+ *Cell Cycle Proteins/me [Metabolism]
+ Cell Line, Tumor
+ Cell Movement/ge [Genetics]
+ Cell Proliferation
+ Disease Models, Animal
+ Energy Metabolism
+ *Esophageal Squamous Cell Carcinoma/et [Etiology]
+ *Esophageal Squamous Cell Carcinoma/me [Metabolism]
+ Esophageal Squamous Cell Carcinoma/pa [Pathology]
+ Gene Expression
+ Heterografts
+ Humans
+ Male
+ Matrix Metalloproteinase 9/ge [Genetics]
+ Matrix Metalloproteinase 9/me [Metabolism]
+ Mice
+ *Obesity/co [Complications]
+ *Signal Transduction
+ *Transcription Factors/me [Metabolism]
+Abstract
+ Obesity could increase the risk of esophageal squamous cell carcinoma (ESCC) and affect its growth and progression, but the mechanical links are unclear. The objective of the study was to explore the impact of obesity on ESCC growth and progression utilizing in vivo trials and cell experiments in vitro. Diet-induced obese and lean nude mice were inoculated with TE-1 cells, then studied for 4 weeks. Serum glucose, insulin, leptin, and visfatin levels were assayed. Sera of nude mice were obtained and then utilized to culture TE-1. MTT, migration and invasion assays, RT-PCR, and Western blotting were used to analyze endocrine effect of obesity on cell proliferation, migration, invasion, and related genes expression of TE-1. Obese nude mice bore larger tumor xenografts than lean animals, and were hyperglycemic and hyperinsulinemic with an elevated level of leptin and visfatin in sera, and also were accompanied by a fatty liver. As for the subcutaneous tumor xenograft model, tumors were more aggressive in obese nude mice than lean animals. Tumor weight correlated positively with mouse body weight, liver weight of mice, serum glucose, HOMA-IR, leptin, and visfatin. Obesity prompted significant TE-1 cell proliferation, migration, and invasion by endocrine mechanisms and impacted target genes. The expression of AMPK and p-AMPK protein decreased significantly (P < 0.05); MMP9, total YAP, p-YAP, and nonphosphorylated YAP protein increased significantly (P < 0.05) in the cells cultured with conditioned media and xenograft tumor from the obese group; the mRNA expression of AMPK decreased significantly (P < 0.05); YAP and MMP9 mRNA expression increased significantly (P < 0.05) in the cells exposed to conditioned media from the obese group. In conclusion, the altered adipokine milieu and metabolites in the context of obesity may promote ESCC growth in vivo; affect proliferation, migration, and invasion of ESCC cells in vitro; and regulate MMP9 and AMPK-YAP signaling pathway through complex effects including the endocrine effect. Copyright © 2020 Jia-Huang Liu et al.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cell Cycle Proteins). 0 (Transcription Factors). 0 (YY1AP1 protein, human). EC 2-7-11-31 (AMP-Activated Protein Kinases). EC 3-4-24-35 (Matrix Metalloproteinase 9).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1155%2f2020%2f6765474
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=2314-7156&title=Journal+of+Immunological+Research&atitle=Obesity+Potentiates+Esophageal+Squamous+Cell+Carcinoma+Growth+and+Invasion+by+AMPK-YAP+Pathway.&volume=2020&issue=&spage=6765474&epage=&date=2020&doi=10.1155%2F2020%2F6765474&pmid=33381605&sid=OVID:medline
+
+<1114>
+Unique Identifier
+ 33374256
+Title
+ Sandwich ELISA-Based Electrochemical Biosensor for Leptin in Control and Diet-Induced Obesity Mouse Model.
+Source
+ Biosensors. 11(1), 2020 Dec 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sung R; Heo YS
+Authors Full Name
+ Sung, Ryong; Heo, Yun Seok.
+Institution
+ Sung, Ryong. Obesity-Mediated Disease Research (ODR) Center, School of Medicine, Keimyung University, Daegu 42601, Korea.
+ Heo, Yun Seok. Department of Biomedical Engineering, School of Medicine, Keimyung University, Daegu 42601, Korea.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ *Biosensing Techniques
+ Diet
+ Disease Models, Animal
+ Electrochemical Techniques
+ Electrodes
+ *Enzyme-Linked Immunosorbent Assay
+ Gold
+ Humans
+ *Leptin/an [Analysis]
+ Mice
+ *Obesity/bl [Blood]
+Keyword Heading
+ diet-induced obesity
+ electrochemical immunoassay
+ leptin analysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Leptin is a peptide hormone produced primarily in adipose tissues. Leptin is considered a biomarker associated with obesity and obesity-mediated diseases. Biosensor detection of leptin in the blood may play a critical role as an indicator of dynamic pathological changes. In this paper, we introduce an electrochemical biosensor that adopts o-Phenylenediamine (oPD) on screen-printed gold electrodes (SPGEs) for detecting the leptin from a mouse model of diet-induced obesity (DIO). A linear calibration curve for the leptin concentration was obtained in the ranges from 0.1 to 20 ng/mL with a lower detection limit of 0.033 ng/mL. The leptin concentration was quantified with HRP (horseradish peroxidase)-catalyzed oxidation of oPD by two voltammetry methods: cyclic voltammetry (CV) and square-wave voltammetry (SWV). The proposed sandwich enzyme-linked immunosorbent assay (ELISA)-based electrochemical biosensor for the leptin in mouse blood serum showed high stability, sensitivity, selectivity, and effectivity compared to the commercial Leptin ELISA measurement. Thus, we believe that this leptin biosensor can be a sensitive analytical tool to detect low-levels of biomarkers in clinics and point-of-care testing (POCT).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). 7440-57-5 (Gold).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fbios11010007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sung&issn=2079-6374&title=Biosensors&atitle=Sandwich+ELISA-Based+Electrochemical+Biosensor+for+Leptin+in+Control+and+Diet-Induced+Obesity+Mouse+Model.&volume=11&issue=1&spage=&epage=&date=2020&doi=10.3390%2Fbios11010007&pmid=33374256&sid=OVID:medline
+
+<1115>
+Unique Identifier
+ 33371219
+Title
+ Bioactive Lipids in Health and Disease.
+Source
+ Biomolecules. 10(12), 2020 12 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bari M; Bisogno T; Battista N
+Author NameID
+ Bisogno, Tiziana; ORCID: https://orcid.org/0000-0002-5567-2272
+ Battista, Natalia; ORCID: https://orcid.org/0000-0002-1936-6710
+Authors Full Name
+ Bari, Monica; Bisogno, Tiziana; Battista, Natalia.
+Institution
+ Bari, Monica. Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
+ Bisogno, Tiziana. Endocannabinoid Research Group, Institute of Translational Pharmacology, National Research Council, 00133 Rome, Italy.
+ Battista, Natalia. Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.
+MeSH Subject Headings
+ Arthritis/me [Metabolism]
+ *Biomarkers/me [Metabolism]
+ Cardiovascular Diseases/me [Metabolism]
+ Cell Communication
+ Humans
+ *Lipid Metabolism
+ *Lipids/ch [Chemistry]
+ Microbiota
+ Neurodegenerative Diseases/me [Metabolism]
+ Obesity/me [Metabolism]
+ Prognosis
+ *Signal Transduction
+Abstract
+ Although the primordial concept of lipids is associated with the role they play as key components of the cell membrane, growing research in the field of bioactive lipids and lipidomic technologies proves the prominent role of these molecules in other biological functions [...].
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Editorial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fbiom10121698
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bari&issn=2218-273X&title=Biomolecules&atitle=Bioactive+Lipids+in+Health+and+Disease.&volume=10&issue=12&spage=&epage=&date=2020&doi=10.3390%2Fbiom10121698&pmid=33371219&sid=OVID:medline
+
+<1116>
+Unique Identifier
+ 33364774
+Title
+ Obesity and Preoperative Anaemia as Independent Risk Factors for Sternal Wound Infection After Coronary Artery Bypass Graft Surgery with Pedicled (Non-Skeletonized) Internal Mammary Arteries: The Role of Thoracic Wall Ischemia?.
+Source
+ Vascular Health & Risk Management. 16:553-559, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Brunet A; N'Guyen Y; Lefebvre A; Poncet A; Robbins A; Bajolet O; Saade Y; Ruggieri VG; Rubin S
+Authors Full Name
+ Brunet, Aurelie; N'Guyen, Yohan; Lefebvre, Annick; Poncet, Anne; Robbins, Ailsa; Bajolet, Odile; Saade, Yves; Ruggieri, Vito Giovanni; Rubin, Sylvain.
+Institution
+ Brunet, Aurelie. Internal Medicine, Infectious Diseases and Clinical Immunology, Robert Debre University Hospital, Reims, France.
+ N'Guyen, Yohan. Internal Medicine, Infectious Diseases and Clinical Immunology, Robert Debre University Hospital, Reims, France.
+ Lefebvre, Annick. Operational Hygiene Team, Robert Debre University Hospital, Reims, France.
+ Poncet, Anne. Thoracic and Cardiovascular Surgery, Robert Debre University Hospital, Reims, France.
+ Robbins, Ailsa. Internal Medicine, Infectious Diseases and Clinical Immunology, Robert Debre University Hospital, Reims, France.
+ Bajolet, Odile. Operational Hygiene Team, Robert Debre University Hospital, Reims, France.
+ Saade, Yves. Thoracic and Cardiovascular Surgery, Robert Debre University Hospital, Reims, France.
+ Ruggieri, Vito Giovanni. Thoracic and Cardiovascular Surgery, Robert Debre University Hospital, Reims, France.
+ Rubin, Sylvain. Thoracic and Cardiovascular Surgery, Robert Debre University Hospital, Reims, France.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ *Anemia/co [Complications]
+ Anemia/di [Diagnosis]
+ Anemia/mo [Mortality]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Coronary Artery Bypass/ae [Adverse Effects]
+ Coronary Artery Bypass/mo [Mortality]
+ Female
+ Hemoglobins/an [Analysis]
+ Hospital Mortality
+ Humans
+ Length of Stay
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/mo [Mortality]
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ *Sternotomy/ae [Adverse Effects]
+ Surgical Wound Infection/di [Diagnosis]
+ *Surgical Wound Infection/et [Etiology]
+ Surgical Wound Infection/mo [Mortality]
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ coronary artery bypass graft surgery
+ internal mammary arteries
+ obesity
+ preoperative anaemia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Obesity remains statistically associated with coronary artery disease, for which coronary artery bypass graft surgery (CABG) remains the standard of care. However, obesity is also associated with sternal wound infection (SWI) which is a severe complication of CABG despite advances in surgery and in infection prevention and control. Strategies to reduce the incidence of SWI are still being investigated, and we therefore conducted a retrospective study to revisit factors other than obesity associated with SWI after CABG.
+
+ PATIENTS AND METHODS: Data were extracted from the medical records of 182 patients who underwent elective on-pump CABG using one or both pedicled internal mammary artery grafts in Reims University Hospital between May 2015 and May 2016. All preoperative or perioperative variables with a p value<0.10 in univariate analysis were entered into a stepwise logistic regression model.
+
+ RESULTS: Among the 182 patients (145 male (79.6%), median age 68.0 [45.0-87.0] years), 138 (75.8%) underwent CABG using bilateral internal mammary artery grafts. Median BMI was 27.7 [18.7-50.5] kg/m2, and there were 51 (28.0%) and 79 (43.4%) patients with obesity and overweight, respectively. Twenty-three out of the 182 patients (12.6%) developed SWI. In-hospital mortality was not statistically different between patients with and without SWI but the median length of stay was (6.0 [2.0-38.0] versus 5.0[3.0-21.0] days in the intensive care unit, p=0.03, and 26.0 [9.0-134.0] versus 9.0 [7.0-51.0] days in hospital, p<0.0001). Obesity and preoperative anaemia were independently associated with SWI, as was the number of red blood cell (RBC) units transfused (OR 14.61 [2.64-80.75], OR 4.64 [1.61-13.34] and OR 1.27 [1.02-1.58], respectively).
+
+ CONCLUSION: The independent association of SWI with the number of RBC units transfused and the existence of preoperative anaemia and obesity suggests a mechanism of thoracic wall ischemia in SWI after CABG, thus leaving insufficient perfusion of the thoracic wall in patients with obesity. Medical strategies are warranted to try to prevent this costly complication. Copyright © 2020 Brunet et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hemoglobins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2147%2fVHRM.S264415
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Brunet&issn=1176-6344&title=Vascular+Health+%26+Risk+Management&atitle=Obesity+and+Preoperative+Anaemia+as+Independent+Risk+Factors+for+Sternal+Wound+Infection+After+Coronary+Artery+Bypass+Graft+Surgery+with+Pedicled+%28Non-Skeletonized%29+Internal+Mammary+Arteries%3A+The+Role+of+Thoracic+Wall+Ischemia%3F.&volume=16&issue=&spage=553&epage=559&date=2020&doi=10.2147%2FVHRM.S264415&pmid=33364774&sid=OVID:medline
+
+<1117>
+Unique Identifier
+ 33344653
+Title
+ Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population.
+Source
+ Journal of Diabetes Research. 2020:9157430, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xu M; Huang M; Qiang D; Gu J; Li Y; Pan Y; Yao X; Xu W; Tao Y; Zhou Y; Ma H
+Author NameID
+ Xu, Minrui; ORCID: https://orcid.org/0000-0001-9319-4761
+ Zhou, Yihong; ORCID: https://orcid.org/0000-0002-0221-2504
+ Ma, Hongxia; ORCID: https://orcid.org/0000-0002-2462-9693
+Authors Full Name
+ Xu, Minrui; Huang, Mingtao; Qiang, Deren; Gu, Jianxin; Li, Yong; Pan, Yingzi; Yao, Xingjuan; Xu, Wenchao; Tao, Yuan; Zhou, Yihong; Ma, Hongxia.
+Institution
+ Xu, Minrui. Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
+ Huang, Mingtao. Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
+ Huang, Mingtao. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
+ Huang, Mingtao. Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
+ Huang, Mingtao. Department of Prenatal Diagnosis, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, China.
+ Qiang, Deren. Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
+ Gu, Jianxin. Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
+ Li, Yong. Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
+ Pan, Yingzi. Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
+ Yao, Xingjuan. Changzhou Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
+ Xu, Wenchao. Changzhou Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
+ Tao, Yuan. Department of Medical Affairs, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
+ Zhou, Yihong. Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
+ Ma, Hongxia. Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
+ Ma, Hongxia. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
+ Ma, Hongxia. Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ China/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ Humans
+ Hypertriglyceridemia/bl [Blood]
+ *Hypertriglyceridemia/di [Diagnosis]
+ Hypertriglyceridemia/ep [Epidemiology]
+ Incidence
+ *Lipid Accumulation Product
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Predictive Value of Tests
+ Prognosis
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Rural Health
+ *Triglycerides/bl [Blood]
+ *Waist Circumference
+Abstract
+ PURPOSE: To determine whether hypertriglyceridemic waist (HTGW) and high lipid accumulation product (LAP) preceded the incidence of type 2 diabetes mellitus (T2DM), and to investigate the interactions of HTGW and LAP with other components of metabolic syndrome on the risk of T2DM.
+
+ METHODS: A total of 15,717 eligible participants without baseline T2DM and aged 35 and over were included from a Chinese rural cohort. Cox proportional hazards regression models were used to estimate the association of HTGW and LAP with the incidence of T2DM, and the restricted cubic spline model was used to evaluate the dose-response association.
+
+ RESULTS: Overall, 867 new T2DM cases were diagnosed after 7.77 years of follow-up. Participants with HTGW had a higher hazard ratio for T2DM (hazard ratio (HR): 6.249, 95% confidence interval (CI): 5.199-7.511) after adjustment for potential confounders. The risk of incident T2DM was increased with quartiles 3 and 4 versus quartile 1 of LAP, and the adjusted HRs (95% CIs) were 2.903 (2.226-3.784) and 6.298 (4.911-8.077), respectively. There were additive interactions of HTGW (synergy index (SI): 1.678, 95% CI: 1.358-2.072) and high LAP (SI: 1.701, 95% CI: 1.406-2.059) with increased fasting plasma glucose (FPG) on the risk of T2DM. Additionally, a nonlinear (P nonlinear < 0.001) dose-response association was found between LAP and T2DM.
+
+ CONCLUSION: The subjects with HTGW and high LAP were at high risk of developing T2DM, and the association between LAP and the risk of T2DM may be nonlinear. Our study further demonstrates additive interactions of HTGW and high LAP with increased FPG on the risk of T2DM. Copyright © 2020 Minrui Xu et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1155%2f2020%2f9157430
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xu&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=Hypertriglyceridemic+Waist+Phenotype+and+Lipid+Accumulation+Product%3A+Two+Comprehensive+Obese+Indicators+of+Waist+Circumference+and+Triglyceride+to+Predict+Type+2+Diabetes+Mellitus+in+Chinese+Population.&volume=2020&issue=&spage=9157430&epage=&date=2020&doi=10.1155%2F2020%2F9157430&pmid=33344653&sid=OVID:medline
+
+<1118>
+Unique Identifier
+ 33339214
+Title
+ Unripe Rubus coreanus Miquel Extract Containing Ellagic Acid Promotes Lipolysis and Thermogenesis In Vitro and In Vivo.
+Source
+ Molecules. 25(24), 2020 Dec 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim KJ; Jeong ES; Lee KH; Na JR; Park S; Kim JS; Na CS; Kim YR; Kim S
+Author NameID
+ Kim, Sunoh; ORCID: https://orcid.org/0000-0003-0407-6339
+Authors Full Name
+ Kim, Kyeong Jo; Jeong, Eui-Seon; Lee, Ki Hoon; Na, Ju-Ryun; Park, Soyi; Kim, Jin Seok; Na, Chang-Su; Kim, Young Ran; Kim, Sunoh.
+Institution
+ Kim, Kyeong Jo. Central R&D Center, Bioresources and Technology (B&Tech) Co., Ltd., Gwangju 61239, Korea.
+ Kim, Kyeong Jo. College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
+ Jeong, Eui-Seon. Central R&D Center, Bioresources and Technology (B&Tech) Co., Ltd., Gwangju 61239, Korea.
+ Lee, Ki Hoon. Central R&D Center, Bioresources and Technology (B&Tech) Co., Ltd., Gwangju 61239, Korea.
+ Na, Ju-Ryun. Central R&D Center, Bioresources and Technology (B&Tech) Co., Ltd., Gwangju 61239, Korea.
+ Park, Soyi. Central R&D Center, Bioresources and Technology (B&Tech) Co., Ltd., Gwangju 61239, Korea.
+ Kim, Jin Seok. Central R&D Center, Bioresources and Technology (B&Tech) Co., Ltd., Gwangju 61239, Korea.
+ Na, Chang-Su. College of Korean Medicine, Dongshin University, Naju-si, Jeollanam-do 58245, Korea.
+ Kim, Young Ran. College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
+ Kim, Sunoh. Central R&D Center, Bioresources and Technology (B&Tech) Co., Ltd., Gwangju 61239, Korea.
+MeSH Subject Headings
+ Adipogenesis/ge [Genetics]
+ Adipose Tissue, White/de [Drug Effects]
+ Adipose Tissue, White/me [Metabolism]
+ Adipose Tissue, White/pa [Pathology]
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ Diet, High-Fat
+ Down-Regulation/de [Drug Effects]
+ Ellagic Acid/ad [Administration & Dosage]
+ *Ellagic Acid/ch [Chemistry]
+ Ellagic Acid/ip [Isolation & Purification]
+ Ellagic Acid/pd [Pharmacology]
+ Lipogenesis/ge [Genetics]
+ *Lipolysis/de [Drug Effects]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/dt [Drug Therapy]
+ Obesity/ve [Veterinary]
+ PPAR alpha/ge [Genetics]
+ PPAR alpha/me [Metabolism]
+ Plant Extracts/ad [Administration & Dosage]
+ Plant Extracts/ch [Chemistry]
+ *Plant Extracts/pd [Pharmacology]
+ *Rubus/ch [Chemistry]
+ Rubus/me [Metabolism]
+ *Thermogenesis/de [Drug Effects]
+ Uncoupling Protein 1/ge [Genetics]
+ Uncoupling Protein 1/me [Metabolism]
+Keyword Heading
+ ATGL
+ PGC1alpha
+ PPARalpha
+ UCP1
+ antiobesity
+ ellagic acid
+ unripe Rubus coreanus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Previously, we demonstrated that a 5% ethanol extract of unripe Rubus coreanus (5-uRCK) and ellagic acid has hypocholesterolemic and antiobesity activity, at least partially mediated by the downregulation of adipogenic and lipogenic gene expression in high-fat diet (HFD)-fed animals. The present study investigated the thermogenic and lipolytic antiobesity effects of 5-uRCK and ellagic acid in HFD-induced obese C57BL/6 mice and explored its mechanism of action. Mice fed an HFD received 5-uRCK or ellagic acid as a post-treatment or pretreatment. Both post-treated and pretreated mice showed significant reductions in body weight and adipose tissue mass compared to the HFD-fed mice. The protein levels of lipolysis-associated proteins, such as adipose triglyceride lipase (ATGL), phosphorylated hormone-sensitive lipase (p-HSL), and perilipin1 (PLIN1), were significantly increased in both the 5-uRCK- and ellagic acid-treated mouse epididymal white adipose tissue (eWAT). Additionally, thermogenesis-associated proteins, such as peroxisome proliferator-activated receptor alpha (PPARalpha), carnitine palmitoyl transferase-1 (CPT1), uncoupling protein 1 (UCP1), and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC1alpha), in inguinal white adipose tissue (ingWAT) were clearly increased in both the 5-uRCK- and ellagic acid-treated mice compared to HFD-fed mice. These results suggest that 5-uRCK and ellagic acid are effective for suppressing body weight gain and enhancing the lipid profile.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (PPAR alpha). 0 (Plant Extracts). 0 (Ucp1 protein, mouse). 0 (Uncoupling Protein 1). 19YRN3ZS9P (Ellagic Acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fmolecules25245954
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1420-3049&title=Molecules&atitle=Unripe+Rubus+coreanus+Miquel+Extract+Containing+Ellagic+Acid+Promotes+Lipolysis+and+Thermogenesis+In+Vitro+and+In+Vivo.&volume=25&issue=24&spage=5954&epage=&date=2020&doi=10.3390%2Fmolecules25245954&pmid=33339214&sid=OVID:medline
+
+<1119>
+Unique Identifier
+ 33335235
+Title
+ The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis.
+Source
+ Scientific Reports. 10(1):22194, 2020 12 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sohouli MH; Sharifi-Zahabi E; Lari A; Fatahi S; Shidfar F
+Authors Full Name
+ Sohouli, Mohammad Hassan; Sharifi-Zahabi, Elham; Lari, Abolfazl; Fatahi, Somaye; Shidfar, Farzad.
+Institution
+ Sohouli, Mohammad Hassan. Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran.
+ Sohouli, Mohammad Hassan. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Hemmat Superhighway, Tehran, Iran.
+ Sharifi-Zahabi, Elham. Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran.
+ Sharifi-Zahabi, Elham. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Hemmat Superhighway, Tehran, Iran.
+ Lari, Abolfazl. Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran.
+ Lari, Abolfazl. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Hemmat Superhighway, Tehran, Iran.
+ Fatahi, Somaye. Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran.
+ Fatahi, Somaye. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Hemmat Superhighway, Tehran, Iran.
+ Shidfar, Farzad. Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran. shidfar.f@iums.ac.ir.
+ Shidfar, Farzad. Pediatric growth and development research center, Iran University of Medical Sciences, Tehran, Iran. shidfar.f@iums.ac.ir.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Body Weights and Measures
+ *Diet
+ Disease Susceptibility
+ *Glycation End Products, Advanced/ad [Administration & Dosage]
+ *Hormones/me [Metabolism]
+ Humans
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+Abstract
+ Several randomized clinical trials (RCTs) have investigated the effect of dietary advanced glycation end products (AGE) on obesity factors and related hormones in adults; results were conflicting. Therefore, a study was performed to assess the effect of low advanced glycation end products diet on obesity and related hormones. A comprehensive literature search without any limitation on language was conducted using the following bibliographical databases: Web of Science, Scopus, Ovid MEDLINE, Cochrane, and Embase up to October, 2019. From the eligible trials, 13 articles were selected for the systematic review and meta-analysis. Our systematic reviews and meta-analyses have shown a significant decrease in BMI (WMD: - 0.3 kg/m2; 95% CI: - 0.52, - 0.09, p = 0.005; I2 = 55.8%), weight (WMD: - 0.83 kg; 95% CI: - 1.55, - 0.10, p = 0.026; I2 = 67.0%), and leptin (WMD: - 19.85 ng/ml; 95% CI: - 29.88, - 9.82, p < 0.001; I2 = 81.8%) and an increase in adiponectin (WMD: 5.50 microg/ml; 95% CI: 1.33, 9.67, p = 0.010; I2 = 90.6%) levels after consumption of the low AGE diets compared to the high AGE diets. Also, the effect of intake of low AGE compared to high AGE diets was more pronounced in subgroup with duration > 8 weeks for the BMI and weight. Overall, according to our results, although low AGE diets appeared to be statistically significant in reducing the prevalence of obesity and chronic diseases compared to high consumption of dietary AGEs. But, no clinical significance was observed. Therefore, to confirm these results clinically, further prospective studies should be conducted in this regard. The study protocol was registered in the in International prospective register of systematic reviews (PROSPERO) database as CRD42020203734.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycation End Products, Advanced). 0 (Hormones).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-79216-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sohouli&issn=2045-2322&title=Scientific+Reports&atitle=The+impact+of+low+advanced+glycation+end+products+diet+on+obesity+and+related+hormones%3A+a+systematic+review+and+meta-analysis.&volume=10&issue=1&spage=22194&epage=&date=2020&doi=10.1038%2Fs41598-020-79216-y&pmid=33335235&sid=OVID:medline
+
+<1120>
+Unique Identifier
+ 33329392
+Title
+ Complement C1q as a Potential Biomarker for Obesity and Metabolic Syndrome in Chinese Adolescents.
+Source
+ Frontiers in Endocrinology. 11:586440, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang X; Ma Y; Zhao Z; Zhen S; Wen D
+Authors Full Name
+ Yang, Xuelian; Ma, Yanan; Zhao, Zhongyi; Zhen, Shihan; Wen, Deliang.
+Institution
+ Yang, Xuelian. Institute of Health Sciences, China Medical University, Shenyang, China.
+ Ma, Yanan. School of Public Health, China Medical University, Shenyang, China.
+ Zhao, Zhongyi. Department of Health Management, Shengjing Hospital of China Medical University, Shenyang, China.
+ Zhen, Shihan. Institute of Health Sciences, China Medical University, Shenyang, China.
+ Wen, Deliang. Institute of Health Sciences, China Medical University, Shenyang, China.
+MeSH Subject Headings
+ Adolescent
+ Area Under Curve
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ China/ep [Epidemiology]
+ *Complement C1q/an [Analysis]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Hyperglycemia/bl [Blood]
+ Hyperglycemia/ep [Epidemiology]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/ep [Epidemiology]
+ *Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Odds Ratio
+ Prevalence
+ ROC Curve
+ Risk Factors
+ Waist Circumference
+Keyword Heading
+ C1q
+ adolescent
+ biomarker
+ metabolic syndrome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Complement C1q (C1q) has been confirmed to be related to obesity, metabolic syndrome (MetS), and its components. However, human data regarding the associations are relatively scarce. This study aimed to investigate associations of C1q with obesity as well as MetS in Chinese adolescents.
+
+ Methods: A total of 1,191 Chinese adolescents aged 13-18 years were enrolled in this study. The biochemical and anthropometric variables of all the subjects were evaluated using standardized procedures. C1q was measured using the immunoturbidometric assay. The relationship between C1q and obesity or MetS was analyzed using multiple regression analyses.
+
+ Results: Obesity was more prevalent among participants in the highest tertile than in the lowest tertile of C1q levels. The highest tertile of C1q was related to a greater effect on the risk of MetS, and its trend test was statistically significant. Except for hyperglycemia, the prevalence of other components of MetS significantly increased relative to an increase in C1q tertile. Receiver operating characteristic (ROC) curve analysis of C1q for predicting adolescents with MetS illustrated that the area under the curve (AUC) was 0.82 [95% confidence interval (CI): 0.76, 0.88; P<0.001] in the total population after adjusting for confounders.
+
+ Conclusions: This study observed a significantly higher prevalence of obesity and MetS features in adolescents with high C1q. The findings of the current study also reported a significant relationship between C1q levels and MetS components [except for fasting plasma glucose (FPG)] in Chinese adolescents. C1q may represent a biomarker for predicting obesity or MetS in adolescents. Copyright © 2020 Yang, Ma, Zhao, Zhen and Wen.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 80295-33-6 (Complement C1q).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffendo.2020.586440
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Complement+C1q+as+a+Potential+Biomarker+for+Obesity+and+Metabolic+Syndrome+in+Chinese+Adolescents.&volume=11&issue=&spage=586440&epage=&date=2020&doi=10.3389%2Ffendo.2020.586440&pmid=33329392&sid=OVID:medline
+
+<1121>
+Unique Identifier
+ 33327530
+Title
+ Comprehensive Analysis Reveals Novel Interactions between Circulating MicroRNAs and Gut Microbiota Composition in Human Obesity.
+Source
+ International Journal of Molecular Sciences. 21(24), 2020 Dec 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Assmann TS; Cuevas-Sierra A; Riezu-Boj JI; Milagro FI; Martinez JA
+Author NameID
+ Assmann, Tais Silveira; ORCID: https://orcid.org/0000-0001-9114-8243
+ Cuevas-Sierra, Amanda; ORCID: https://orcid.org/0000-0003-2631-2566
+ Riezu-Boj, Jose Ignacio; ORCID: https://orcid.org/0000-0002-1885-8457
+ Milagro, Fermin I; ORCID: https://orcid.org/0000-0002-3228-9916
+ Martinez, J Alfredo; ORCID: https://orcid.org/0000-0001-5218-6941
+Authors Full Name
+ Assmann, Tais Silveira; Cuevas-Sierra, Amanda; Riezu-Boj, Jose Ignacio; Milagro, Fermin I; Martinez, J Alfredo.
+Institution
+ Assmann, Tais Silveira. Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
+ Cuevas-Sierra, Amanda. Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
+ Riezu-Boj, Jose Ignacio. Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
+ Riezu-Boj, Jose Ignacio. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Carlos III Health Institute, 28029 Madrid, Spain.
+ Riezu-Boj, Jose Ignacio. IdiSNA-Navarra Institute for Health Research, 31008 Pamplona, Spain.
+ Milagro, Fermin I. Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
+ Milagro, Fermin I. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Carlos III Health Institute, 28029 Madrid, Spain.
+ Milagro, Fermin I. IdiSNA-Navarra Institute for Health Research, 31008 Pamplona, Spain.
+ Martinez, J Alfredo. Center for Nutrition Research, Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
+ Martinez, J Alfredo. Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Carlos III Health Institute, 28029 Madrid, Spain.
+ Martinez, J Alfredo. IdiSNA-Navarra Institute for Health Research, 31008 Pamplona, Spain.
+MeSH Subject Headings
+ Bacteroides/ph [Physiology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Circulating MicroRNA/bl [Blood]
+ Gastrointestinal Microbiome/ph [Physiology]
+ Humans
+ *MicroRNAs/bl [Blood]
+ *Obesity/bl [Blood]
+ Polymerase Chain Reaction
+Keyword Heading
+ BMI
+ Bacteroides eggerthi
+ gut microbiota
+ miRNA
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The determinants that mediate the interactions between microRNAs and the gut microbiome impacting on obesity are scarcely understood. Thus, the aim of this study was to investigate possible interactions between circulating microRNAs and gut microbiota composition in obesity.
+
+ METHOD: The sample comprised 78 subjects with obesity (cases, body mass index (BMI): 30-40 kg/m2) and 25 eutrophic individuals (controls, BMI <= 25 kg/m2). The expression of 96 microRNAs was investigated in plasma of all individuals using miRCURY LNA miRNA Custom PCR Panels. Bacterial DNA sequencing was performed following the Illumina 16S protocol. The FDR correction was used for multiple comparison analyses.
+
+ RESULTS: A total of 26 circulating microRNAs and 12 bacterial species were found differentially expressed between cases and controls. Interestingly, an interaction among three miRNAs (miR-130b-3p, miR-185-5p and miR-21-5p) with Bacteroides eggerthi and BMI levels was evidenced (r2 = 0.148, p = 0.004). Moreover, these microRNAs regulate genes that participate in metabolism-related pathways, including fatty acid degradation, insulin signaling and glycerolipid metabolism.
+
+ CONCLUSIONS: This study characterized an interaction between the abundance of 4 bacterial species and 14 circulating microRNAs in relation to obesity. Moreover, the current study also suggests that miRNAs may serve as a communication mechanism between the gut microbiome and human hosts.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Circulating MicroRNA). 0 (MicroRNAs).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21249509
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Assmann&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Comprehensive+Analysis+Reveals+Novel+Interactions+between+Circulating+MicroRNAs+and+Gut+Microbiota+Composition+in+Human+Obesity.&volume=21&issue=24&spage=9509&epage=&date=2020&doi=10.3390%2Fijms21249509&pmid=33327530&sid=OVID:medline
+
+<1122>
+Unique Identifier
+ 33322303
+Title
+ Herring Milt and Herring Milt Protein Hydrolysate Are Equally Effective in Improving Insulin Sensitivity and Pancreatic Beta-Cell Function in Diet-Induced Obese- and Insulin-Resistant Mice.
+Source
+ Marine Drugs. 18(12), 2020 Dec 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang Y; Nair S; Gagnon J
+Author NameID
+ Wang, Yanwen; ORCID: https://orcid.org/0000-0003-0267-0377
+ Gagnon, Jacques; ORCID: https://orcid.org/0000-0001-5616-8249
+Authors Full Name
+ Wang, Yanwen; Nair, Sandhya; Gagnon, Jacques.
+Institution
+ Wang, Yanwen. Aquatic and Crop Resource Development Research Center, National Research Council of Canada, Charlottetown, PE C1A 4P3, Canada.
+ Wang, Yanwen. Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.
+ Nair, Sandhya. Aquatic and Crop Resource Development Research Center, National Research Council of Canada, Charlottetown, PE C1A 4P3, Canada.
+ Nair, Sandhya. VALORES Research Institute, Shippagan, NB E8S 1J2, Canada.
+ Gagnon, Jacques. VALORES Research Institute, Shippagan, NB E8S 1J2, Canada.
+ Gagnon, Jacques. Department of Sciences, Shippagan Campus, University of Moncton, Shippagan, NB E8S 1P6, Canada.
+MeSH Subject Headings
+ Animal Feed
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ Energy Intake
+ Fatty Acids, Nonesterified/bl [Blood]
+ *Fish Proteins, Dietary/ad [Administration & Dosage]
+ Fish Proteins, Dietary/me [Metabolism]
+ *Glycemic Control
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ *Insulin-Secreting Cells/me [Metabolism]
+ Leptin/bl [Blood]
+ Male
+ Mice, Inbred C57BL
+ *Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ *Protein Hydrolysates/ad [Administration & Dosage]
+ Protein Hydrolysates/me [Metabolism]
+ Weight Loss
+Keyword Heading
+ HOMA-IR
+ HOMA-beta
+ QUICKI
+ blood glucose
+ herring milt dry powder
+ herring milt protein hydrolysate
+ high-fat diet
+ insulin resistance
+ mice
+ oral glucose tolerance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Although genetic predisposition influences the onset and progression of insulin resistance and diabetes, dietary nutrients are critical. In general, protein is beneficial relative to carbohydrate and fat but dependent on protein source. Our recent study demonstrated that 70% replacement of dietary casein protein with the equivalent quantity of protein derived from herring milt protein hydrolysate (HMPH; herring milt with proteins being enzymatically hydrolyzed) significantly improved insulin resistance and glucose homeostasis in high-fat diet-induced obese mice. As production of protein hydrolysate increases the cost of the product, it is important to determine whether a simply dried and ground herring milt product possesses similar benefits. Therefore, the current study was conducted to investigate the effect of herring milt dry powder (HMDP) on glucose control and the associated metabolic phenotypes and further to compare its efficacy with HMPH. Male C57BL/6J mice on a high-fat diet for 7 weeks were randomized based on body weight and blood glucose into three groups. One group continued on the high-fat diet and was used as the insulin-resistant/diabetic control and the other two groups were given the high-fat diet modified to have 70% of casein protein being replaced with the same amount of protein from HMDP or HMPH. A group of mice on a low-fat diet all the time was used as the normal control. The results demonstrated that mice on the high-fat diet increased weight gain and showed higher blood concentrations of glucose, insulin, and leptin, as well as impaired glucose tolerance and pancreatic beta-cell function relative to those on the normal control diet. In comparison with the high-fat diet, the replacement of 70% dietary casein protein with the same amount of HMDP or HMPH protein decreased weight gain and significantly improved the aforementioned biomarkers, insulin sensitivity or resistance, and beta-cell function. The HMDP and HMPH showed similar effects on every parameter except blood lipids where HMDP decreased total cholesterol and non-HDL-cholesterol levels while the effect of HMPH was not significant. The results demonstrate that substituting 70% of dietary casein protein with the equivalent amount of HMDP or HMPH protein protects against obesity and diabetes, and HMDP is also beneficial to cholesterol homeostasis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Fatty Acids, Nonesterified). 0 (Fish Proteins, Dietary). 0 (Insulin). 0 (Leptin). 0 (Protein Hydrolysates).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fmd18120635
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1660-3397&title=Marine+Drugs&atitle=Herring+Milt+and+Herring+Milt+Protein+Hydrolysate+Are+Equally+Effective+in+Improving+Insulin+Sensitivity+and+Pancreatic+Beta-Cell+Function+in+Diet-Induced+Obese-+and+Insulin-Resistant+Mice.&volume=18&issue=12&spage=&epage=&date=2020&doi=10.3390%2Fmd18120635&pmid=33322303&sid=OVID:medline
+
+<1123>
+Unique Identifier
+ 33322261
+Title
+ The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity.
+Source
+ Nutrients. 12(12), 2020 Dec 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hakim O; Bello O; Ladwa M; Peacock JL; Umpleby AM; Charles-Edwards G; Amiel SA; Goff LM
+Author NameID
+ Hakim, Olah; ORCID: https://orcid.org/0000-0001-7134-4773
+ Ladwa, Meera; ORCID: https://orcid.org/0000-0002-2775-342X
+ Goff, Louise M; ORCID: https://orcid.org/0000-0001-9633-8759
+Authors Full Name
+ Hakim, Olah; Bello, Oluwatoyosi; Ladwa, Meera; Peacock, Janet L; Umpleby, A Margot; Charles-Edwards, Geoffrey; Amiel, Stephanie A; Goff, Louise M.
+Institution
+ Hakim, Olah. Diabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UK.
+ Bello, Oluwatoyosi. Diabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UK.
+ Ladwa, Meera. Diabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UK.
+ Peacock, Janet L. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH 03755-1404, USA.
+ Peacock, Janet L. School of Population Health and Environmental Sciences, King's College London, London SE1 7EH, UK.
+ Umpleby, A Margot. Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
+ Charles-Edwards, Geoffrey. Medical Physics, Guy's & St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
+ Charles-Edwards, Geoffrey. School of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EH, UK.
+ Amiel, Stephanie A. Diabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UK.
+ Goff, Louise M. Diabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UK.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adipose Tissue/dg [Diagnostic Imaging]
+ Adipose Tissue/pp [Physiopathology]
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ *Black People/sn [Statistics & Numerical Data]
+ Body Fat Distribution
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/eh [Ethnology]
+ Humans
+ *Inflammation Mediators/bl [Blood]
+ Magnetic Resonance Imaging
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/eh [Ethnology]
+ *White People/sn [Statistics & Numerical Data]
+ Young Adult
+Keyword Heading
+ African
+ deep subcutaneous adipose tissue
+ ethnicity
+ inflammation
+ superficial subcutaneous adipose tissue
+ type 2 diabetes
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In this study, we aimed to assess ethnic differences in visceral (VAT), deep subcutaneous (dSAT), and superficial subcutaneous (sSAT) adipose tissue and their relationships with inflammatory markers between white European (WE) and black West African (BWA) men with normal glucose tolerance (NGT) and type 2 diabetes (T2D). Forty-two WE (23 NGT/19 T2D) and 43 BWA (23 NGT/20 T2D) men underwent assessment of plasma inflammatory markers using immunoassays alongside Dixon magnetic resonance imaging to quantify L4-5 VAT, dSAT and sSAT. Despite no ethnic differences in sSAT and dSAT, BWA men exhibited lower VAT (p = 0.002) and dSAT:sSAT (p = 0.047) than WE men. Adiponectin was inversely associated with sSAT in WE (p = 0.041) but positively associated in BWA (p = 0.031) men with T2D. Interleukin-6 (IL-6) was associated with VAT in WE but not in BWA men with NGT (WE: p = 0.009, BWA: p = 0.137) and T2D (WE: p = 0.070, BWA: p = 0.175). IL-6 was associated with dSAT in only WE men with NGT (WE: p = 0.030, BWA: p = 0.833). The only significant ethnicity interaction present was for the relationship between adiponectin and sSAT (Pinteraction = 0.003). The favourable adipose tissue distribution and the weaker relationships between adiposity and inflammation in BWA men suggest that adipose tissue inflammation may play a lesser role in T2D in BWA than WE men.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12123796
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hakim&issn=2072-6643&title=Nutrients&atitle=The+Link+between+Obesity+and+Inflammatory+Markers+in+the+Development+of+Type+2+Diabetes+in+Men+of+Black+African+and+White+European+Ethnicity.&volume=12&issue=12&spage=&epage=&date=2020&doi=10.3390%2Fnu12123796&pmid=33322261&sid=OVID:medline
+
+<1124>
+Unique Identifier
+ 33299020
+Title
+ Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia.
+Source
+ Scientific Reports. 10(1):21507, 2020 12 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Morel S; Leveille P; Samoilenko M; Franco A; England J; Malaquin N; Tu V; Cardin GB; Drouin S; Rodier F; Lippe S; Krajinovic M; Laverdiere C; Sinnett D; Lefebvre G; Levy E; Marcil V
+Authors Full Name
+ Morel, Sophia; Leveille, Pauline; Samoilenko, Mariia; Franco, Anita; England, Jade; Malaquin, Nicolas; Tu, Veronique; Cardin, Guillaume B; Drouin, Simon; Rodier, Francis; Lippe, Sarah; Krajinovic, Maja; Laverdiere, Caroline; Sinnett, Daniel; Lefebvre, Genevieve; Levy, Emile; Marcil, Valerie.
+Institution
+ Morel, Sophia. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ Morel, Sophia. Department of Nutrition, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Leveille, Pauline. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ Leveille, Pauline. Department of Psychology, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Samoilenko, Mariia. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ Samoilenko, Mariia. Department of Mathematics, Universite du Quebec a Montreal, Montreal, QC, H3C 3P8, Canada.
+ Franco, Anita. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ England, Jade. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ England, Jade. Department of Pediatrics, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Malaquin, Nicolas. CRCHUM and Institut du Cancer de Montreal, Montreal, QC, H2X 0A9, Canada.
+ Tu, Veronique. CRCHUM and Institut du Cancer de Montreal, Montreal, QC, H2X 0A9, Canada.
+ Cardin, Guillaume B. CRCHUM and Institut du Cancer de Montreal, Montreal, QC, H2X 0A9, Canada.
+ Drouin, Simon. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ Rodier, Francis. CRCHUM and Institut du Cancer de Montreal, Montreal, QC, H2X 0A9, Canada.
+ Rodier, Francis. Department of Radiology, Radio-Oncology, and Nuclear Medicine, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Lippe, Sarah. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ Lippe, Sarah. Department of Psychology, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Krajinovic, Maja. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ Krajinovic, Maja. Department of Pediatrics, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Laverdiere, Caroline. Department of Pediatrics, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Sinnett, Daniel. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ Sinnett, Daniel. Department of Pediatrics, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Lefebvre, Genevieve. Department of Mathematics, Universite du Quebec a Montreal, Montreal, QC, H3C 3P8, Canada.
+ Levy, Emile. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada.
+ Levy, Emile. Department of Nutrition, Universite de Montreal, Montreal, QC, H3T 1C5, Canada.
+ Marcil, Valerie. Research Centre of Sainte-Justine University Health Center, Universite de Montreal, 3175 Cote Ste-Catherine room 4.17.006, Montreal, QC, H3T 1C5, Canada. valerie.marcil@umontreal.ca.
+ Marcil, Valerie. Department of Nutrition, Universite de Montreal, Montreal, QC, H3T 1C5, Canada. valerie.marcil@umontreal.ca.
+MeSH Subject Headings
+ Adiponectin
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Cancer Survivors/sn [Statistics & Numerical Data]
+ *Cardiovascular Diseases/me [Metabolism]
+ Cross-Sectional Studies
+ Dyslipidemias/co [Complications]
+ Female
+ Humans
+ Inflammation/co [Complications]
+ Leptin
+ Male
+ Metabolic Syndrome/me [Metabolism]
+ Obesity/co [Complications]
+ Oxidative Stress/ph [Physiology]
+ *Precursor Cell Lymphoblastic Leukemia-Lymphoma/co [Complications]
+ Precursor Cell Lymphoblastic Leukemia-Lymphoma/me [Metabolism]
+ Quality of Life
+ Risk Factors
+ Young Adult
+Abstract
+ Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We conducted a cross-sectional analysis in 246 cALL survivors (mean age, 22.1 +/- 6.3 years; mean time since diagnosis, 15.5 +/- 5.2 years) and evaluated the associations using a series of logistic regressions. Using structural equation models, we also tested if the relationship between endotoxemia and cardiometabolic complications was mediated by the latent (unobserved) variable inflammation inferred from the observed biomarkers CRP, TNF-alpha and IL-6. High leptin-adiponectin ratio was associated with obesity [adjusted OR = 15.7; 95% CI (6.2-39.7)], insulin resistance [20.6 (5.2-82.1)] and the metabolic syndrome [11.2 (2.6-48.7)]. Higher levels of plasminogen activator inhibitor-1 and tumor necrosis factor-alpha were associated with obesity [3.37 (1.6-7.1) and 2.34 (1.3-4.2), respectively] whereas high C-reactive protein levels were associated with insulin resistance [3.3 (1.6-6.8)], dyslipidemia [2.6 (1.4-4.9)] and MetS [6.5 (2.4-17.9)]. Our analyses provided evidence for a directional relationship between lipopolysaccharide binding protein, related to metabolic endotoxemia, inflammation and cardiometabolic outcomes. Identification of biomarkers and biological mechanisms could open new avenues for prevention strategies to minimize the long-term sequelae, improve follow-up and optimize the quality of life of this high-risk population.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-78493-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Morel&issn=2045-2322&title=Scientific+Reports&atitle=Biomarkers+of+cardiometabolic+complications+in+survivors+of+childhood+acute+lymphoblastic+leukemia.&volume=10&issue=1&spage=21507&epage=&date=2020&doi=10.1038%2Fs41598-020-78493-x&pmid=33299020&sid=OVID:medline
+
+<1125>
+Unique Identifier
+ 33292104
+Title
+ Adipose tissue in health and disease. [Review]
+Source
+ Open Biol. 10(12):200291, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Harvey I; Boudreau A; Stephens JM
+Authors Full Name
+ Harvey, Innocence; Boudreau, Anik; Stephens, Jacqueline M.
+Institution
+ Harvey, Innocence. Adipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
+ Boudreau, Anik. Adipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
+ Stephens, Jacqueline M. Adipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
+ Stephens, Jacqueline M. Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipose Tissue/em [Embryology]
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ *Disease Susceptibility
+ Energy Metabolism
+ Exosomes/me [Metabolism]
+ Extracellular Space/me [Metabolism]
+ *Homeostasis
+ Humans
+ Insulin Resistance
+ Lipolysis
+ Metabolic Diseases/et [Etiology]
+ Metabolic Diseases/me [Metabolism]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Organogenesis
+Keyword Heading
+ adipose tissue
+ endocrine organ
+ insulin resistance
+ metabolic disease
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipose, or fat, tissue (AT) was once considered an inert tissue that primarily existed to store lipids, and was not historically recognized as an important organ in the regulation and maintenance of health. With the rise of obesity and more rigorous research, AT is now recognized as a highly complex metabolic organ involved in a host of important physiological functions, including glucose homeostasis and a multitude of endocrine capabilities. AT dysfunction has been implicated in several disease states, most notably obesity, metabolic syndrome and type 2 diabetes. The study of AT has provided useful insight in developing strategies to combat these highly prevalent metabolic diseases. This review highlights the major functions of adipose tissue and the consequences that can occur when disruption of these functions leads to systemic metabolic dysfunction.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1098%2frsob.200291
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Harvey&issn=2046-2441&title=Open+Biol&atitle=Adipose+tissue+in+health+and+disease.&volume=10&issue=12&spage=200291&epage=&date=2020&doi=10.1098%2Frsob.200291&pmid=33292104&sid=OVID:medline
+
+<1126>
+Unique Identifier
+ 33271781
+Title
+ Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty Liver Disease.
+Source
+ International Journal of Molecular Sciences. 21(23), 2020 Dec 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wilson RB; Zhang R; Chen YJ; Peters KM; Sawyez CG; Sutherland BG; Patel K; Kennelly JP; Leonard KA; Jacobs RL; Wang R; Borradaile NM
+Author NameID
+ Jacobs, Rene L; ORCID: https://orcid.org/0000-0002-5525-1355
+Authors Full Name
+ Wilson, Rachel B; Zhang, Richard; Chen, Yun Jin; Peters, Kia M; Sawyez, Cynthia G; Sutherland, Brian G; Patel, Krisha; Kennelly, John P; Leonard, Kelly-Ann; Jacobs, Rene L; Wang, Rennian; Borradaile, Nica M.
+Institution
+ Wilson, Rachel B. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Zhang, Richard. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Chen, Yun Jin. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Peters, Kia M. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Sawyez, Cynthia G. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Sutherland, Brian G. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Patel, Krisha. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Kennelly, John P. Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.
+ Leonard, Kelly-Ann. Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.
+ Jacobs, Rene L. Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.
+ Wang, Rennian. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Wang, Rennian. Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+ Borradaile, Nica M. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Biopsy
+ Blood Glucose
+ *Body Weight
+ Disease Models, Animal
+ Endoplasmic Reticulum Chaperone BiP
+ *Fasting
+ Gene Expression Profiling
+ Glucose/me [Metabolism]
+ *Hepatitis/et [Etiology]
+ Hepatitis/me [Metabolism]
+ Hepatitis/pa [Pathology]
+ Lipid Metabolism
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Mice
+ *Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+Keyword Heading
+ NAFLD
+ inflammation
+ liver
+ mouse
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Prolonged, isocaloric, time-restricted feeding (TRF) protocols can promote weight loss, improve metabolic dysregulation, and mitigate non-alcoholic fatty liver disease (NAFLD). In addition, 3-day, severe caloric restriction can improve liver metabolism and glucose homeostasis prior to significant weight loss. Thus, we hypothesized that short-term, isocaloric TRF would improve NAFLD and characteristics of metabolic syndrome in diet-induced obese male mice. After 26 weeks of ad libitum access to western diet, mice either continued feeding ad libitum or were provided with access to the same quantity of western diet for 8 h daily, over the course of two weeks. Remarkably, this short-term TRF protocol modestly decreased liver tissue inflammation in the absence of changes in body weight or epidydimal fat mass. There were no changes in hepatic lipid accumulation or other characteristics of NAFLD. We observed no changes in liver lipid metabolism-related gene expression, despite increased plasma free fatty acids and decreased plasma triglycerides in the TRF group. However, liver Grp78 and Txnip expression were decreased with TRF suggesting hepatic endoplasmic reticulum (ER) stress and activation of inflammatory pathways may have been diminished. We conclude that two-week, isocaloric TRF can potentially decrease liver inflammation, without significant weight loss or reductions in hepatic steatosis, in obese mice with NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Endoplasmic Reticulum Chaperone BiP). 0 (Hspa5 protein, mouse). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21239156
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wilson&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Two-Week+Isocaloric+Time-Restricted+Feeding+Decreases+Liver+Inflammation+without+Significant+Weight+Loss+in+Obese+Mice+with+Non-Alcoholic+Fatty+Liver+Disease.&volume=21&issue=23&spage=9156&epage=&date=2020&doi=10.3390%2Fijms21239156&pmid=33271781&sid=OVID:medline
+
+<1127>
+Unique Identifier
+ 33266209
+Title
+ Seminal Plasma Proteomic Biomarkers of Oxidative Stress. [Review]
+Source
+ International Journal of Molecular Sciences. 21(23), 2020 Nov 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cannarella R; Crafa A; Barbagallo F; Mongioi LM; Condorelli RA; Aversa A; Calogero AE; La Vignera S
+Author NameID
+ Cannarella, Rossella; ORCID: https://orcid.org/0000-0003-4599-8487
+ Mongioi, Laura M; ORCID: https://orcid.org/0000-0003-2341-0996
+ Condorelli, Rosita A; ORCID: https://orcid.org/0000-0002-5217-9343
+ Aversa, Antonio; ORCID: https://orcid.org/0000-0002-2989-2618
+ Calogero, Aldo E; ORCID: https://orcid.org/0000-0001-6950-335X
+ La Vignera, Sandro; ORCID: https://orcid.org/0000-0002-7113-2372
+Authors Full Name
+ Cannarella, Rossella; Crafa, Andrea; Barbagallo, Federica; Mongioi, Laura M; Condorelli, Rosita A; Aversa, Antonio; Calogero, Aldo E; La Vignera, Sandro.
+Institution
+ Cannarella, Rossella. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Crafa, Andrea. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Barbagallo, Federica. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Mongioi, Laura M. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Condorelli, Rosita A. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ Aversa, Antonio. Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+ Calogero, Aldo E. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+ La Vignera, Sandro. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/me [Metabolism]
+ Humans
+ Obesity/pa [Pathology]
+ *Oxidative Stress
+ Proteome/me [Metabolism]
+ *Proteomics
+ *Semen/me [Metabolism]
+Keyword Heading
+ male infertility
+ oxidative stress
+ proteome
+ reactive oxygen species
+ seminal plasma
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The prevalence of idiopathic male infertility is high, up to 75% of patients with abnormal sperm parameters. Hence, the research of its causes is mandatory. Oxidative stress (OS) can be responsible for male infertility in 30-80% of cases. In recent years, seminal plasma (SP) proteomics has developed as a useful tool to provide biomarkers of specific diseases. This systematic review aims to collect the available evidence on the changes of SP proteome in patients exposed to OS to provide possible SP biomarkers of sperm OS. To accomplish this, the following keyterms "seminal fluid proteome", "seminal plasma proteome", "oxidative stress", and "sperm oxidative stress" were used and 137 records were found. Among these, 17 were finally included. Nine proteins involved with OS were found overexpressed in patients with OS. Twenty-three proteins were found differentially expressed in patients with clinical conditions associated with OS, such as varicocele, male accessory gland infection/inflammation, cigarette smoke, and obesity. These proteins do not seem to overlap among the clinical conditions taken into account. We speculate that specific SP proteins may mediate OS in different clinical conditions. Altogether, these results suggest that proteomics could help to better understand some of the molecular mechanisms involved in the pathogenesis of infertility. However, further studies are needed to identify potential biomarkers of male infertility with valuable clinical significance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteome).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21239113
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cannarella&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Seminal+Plasma+Proteomic+Biomarkers+of+Oxidative+Stress.&volume=21&issue=23&spage=9113&epage=&date=2020&doi=10.3390%2Fijms21239113&pmid=33266209&sid=OVID:medline
+
+<1128>
+Unique Identifier
+ 33266002
+Title
+ Effects of Cocoa Polyphenols and Dark Chocolate on Obese Adults: A Scoping Review. [Review]
+Source
+ Nutrients. 12(12), 2020 Nov 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Halib H; Ismail A; Mohd Yusof BN; Osakabe N; Mat Daud ZA
+Author NameID
+ Mohd Yusof, Barakatun-Nisak; ORCID: https://orcid.org/0000-0003-0403-5895
+ Mat Daud, Zulfitri Azuan; ORCID: https://orcid.org/0000-0002-4017-107X
+Authors Full Name
+ Halib, Hasmiza; Ismail, Amin; Mohd Yusof, Barakatun-Nisak; Osakabe, Naomi; Mat Daud, Zulfitri Azuan.
+Institution
+ Halib, Hasmiza. Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
+ Halib, Hasmiza. School of Nutrition and Dietetics, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Terengganu 21300, Malaysia.
+ Ismail, Amin. Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
+ Ismail, Amin. Research Center of Excellent (RCoE) Nutrition and Non-communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
+ Mohd Yusof, Barakatun-Nisak. Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
+ Mohd Yusof, Barakatun-Nisak. Research Center of Excellent (RCoE) Nutrition and Non-communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
+ Osakabe, Naomi. Department of Bio-Science and Engineering, Shibaura Institute of Technology, Saitama 337-5780, Japan.
+ Mat Daud, Zulfitri Azuan. Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
+ Mat Daud, Zulfitri Azuan. Research Center of Excellent (RCoE) Nutrition and Non-communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Body Mass Index
+ Body Weight
+ *Cacao/ch [Chemistry]
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Chocolate/an [Analysis]
+ Flavonoids/an [Analysis]
+ Flavonoids/pd [Pharmacology]
+ Humans
+ *Obesity/pc [Prevention & Control]
+ Observational Studies as Topic
+ *Polyphenols/an [Analysis]
+ *Polyphenols/pd [Pharmacology]
+ Randomized Controlled Trials as Topic
+ Waist Circumference
+Keyword Heading
+ cocoa
+ dark chocolate
+ flavanols
+ obese adults
+ obesity
+ polyphenols
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity remains a major public health problem due to its increasing prevalence. Natural products have become common as adjunct therapeutic agents for treating obesity and preventing metabolic diseases. Cocoa and its products are commonly consumed worldwide. Dark chocolate, a rich source of polyphenols, has received attention lately for its beneficial role in the management of obesity; however, conflicting results are still being reported. This scoping review aims to provide a comprehensive understanding of the existing literature on the relationship and effects of cocoa and dark chocolate intake among obese adults. We searched multiple databases for research investigating the consumption of cocoa and/or dark chocolate in managing obesity among adults. This review includes epidemiological and human studies that were published in English over the last 10 years. Our review of the current literature indicates that epidemiological and human trials with obese adults have shown inconsistent results, which may be due to the different populations of subjects, and different types of cocoa products and doses used for intervention. Studies among obese adults are mainly focusing on obese individuals with comorbidities, as such more studies are needed to elucidate the role of cocoa polyphenols in weight control and preventing the risk of chronic diseases among obese individuals without comorbidities as well as healthy individuals. Careful adjustment of confounding factors would be required. The effects of cocoa and dark chocolate intake on obese adults were discussed, and further research is warranted to identify the gaps.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Flavonoids). 0 (Polyphenols).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12123695
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Halib&issn=2072-6643&title=Nutrients&atitle=Effects+of+Cocoa+Polyphenols+and+Dark+Chocolate+on+Obese+Adults%3A+A+Scoping+Review.&volume=12&issue=12&spage=&epage=&date=2020&doi=10.3390%2Fnu12123695&pmid=33266002&sid=OVID:medline
+
+<1129>
+Unique Identifier
+ 33256795
+Title
+ Evaluation of the effect of curcumin and zinc co-supplementation on glycemic measurements, lipid profiles, and inflammatory and antioxidant biomarkers in overweight or obese prediabetic patients: a study protocol for a randomized double-blind placebo-controlled phase 2 clinical trial.
+Source
+ Trials [Electronic Resource]. 21(1):991, 2020 Nov 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karandish M; Mozaffari-Khosravi H; Mohammadi SM; Azhdari M; Cheraghian B
+Author NameID
+ Azhdari, Maryam; ORCID: http://orcid.org/0000-0003-2110-9817
+Authors Full Name
+ Karandish, Majid; Mozaffari-Khosravi, Hassan; Mohammadi, Seyed Mohammad; Azhdari, Maryam; Cheraghian, Bahman.
+Institution
+ Karandish, Majid. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Mozaffari-Khosravi, Hassan. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Mohammadi, Seyed Mohammad. School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Azhdari, Maryam. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. azhdari_mar@yahoo.com.
+ Azhdari, Maryam. Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. azhdari_mar@yahoo.com.
+ Cheraghian, Bahman. Department of Biostatistics and Epidemiology, School of Health Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Antioxidants/ae [Adverse Effects]
+ Biomarkers
+ Blood Glucose
+ Clinical Trials, Phase II as Topic
+ Curcumin/ae [Adverse Effects]
+ *Curcumin
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 2
+ Dietary Supplements
+ Double-Blind Method
+ Female
+ Humans
+ Iran
+ Lipids
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/dt [Drug Therapy]
+ Overweight/di [Diagnosis]
+ Overweight/dt [Drug Therapy]
+ Prediabetic State/di [Diagnosis]
+ Prediabetic State/dt [Drug Therapy]
+ *Prediabetic State
+ Quality of Life
+ Randomized Controlled Trials as Topic
+ Young Adult
+ Zinc
+Keyword Heading
+ Antioxidant biomarkers
+ Curcumin
+ Glycemic measurement
+ Inflammatory biomarkers
+ Lipid profile
+ Prediabetes
+ Randomized controlled trial
+ Zinc
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The prevalence of prediabetes is increasing worldwide. Unfortunately, prediabetes is related to non-communicable diseases. A high risk of developing type 2 diabetes mellitus (T2DM) is reported in people with prediabetes. Curcumin, a polyphenol, might lead to its therapeutic role in obesity and some obesity-related metabolic diseases. Zinc is a trace element that plays a key role in the synthesis and action of insulin, carbohydrate metabolism, and decreasing inflammation. There has been no clinical trial of zinc and curcumin co-supplementation in patients with prediabetes. In previous studies, the single administration of zinc or curcumin has not been conducted on many of the studied markers in prediabetic patients.
+
+ METHODS: The purpose of this randomized double-blind placebo-controlled clinical trial is to investigate the effect of curcumin and zinc co-supplementation on glycemic measurements, lipid profiles, and inflammatory and antioxidant biomarkers among 84 prediabetic patients with body mass index (BMI) between 25 and 35. Also, liver enzyme, serum zinc, urine zinc, blood pressure, anthropometric parameters, quality of life, adherence to co-supplementation, the side effects of co-supplementation, physical activity, and dietary intake will be assessed. Women or men (18-50 years old for men and 18 years to before menopause for women) will be followed for 3 months (90 days). This study will be conducted at Yazd Diabetes Research Clinic, Shahid Sadoughi University of Medical Sciences.
+
+ DISCUSSION: A diet rich in antioxidants, polyphenols, and phytochemicals has been shown to have a beneficial role in prediabetes. According to the beneficial properties of curcumin or zinc and inadequate evidence, RCTs are needed to assess the effect of curcumin and zinc co-supplementation in native prediabetes patients. We hope the results of the present trial, negative or positive, fill this gap in the literature and facilitate the approach for a much larger, multi-center clinical trial. In conclusion, a synergic effect of co-supplementation along with a weight-loss diet may delay the progression to type 2 diabetes mellitus.
+
+ TRIAL REGISTRATION: Iranian Registry of Clinical Trials (IRCT) IRCT20190902044671N1 . Registered on 11 October 2019.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). IT942ZTH98 (Curcumin). J41CSQ7QDS (Zinc).
+Publication Type
+ Clinical Trial Protocol. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs13063-020-04923-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karandish&issn=1745-6215&title=Trials+%5BElectronic+Resource%5D&atitle=Evaluation+of+the+effect+of+curcumin+and+zinc+co-supplementation+on+glycemic+measurements%2C+lipid+profiles%2C+and+inflammatory+and+antioxidant+biomarkers+in+overweight+or+obese+prediabetic+patients%3A+a+study+protocol+for+a+randomized+double-blind+placebo-controlled+phase+2+clinical+trial.&volume=21&issue=1&spage=991&epage=&date=2020&doi=10.1186%2Fs13063-020-04923-w&pmid=33256795&sid=OVID:medline
+
+<1130>
+Unique Identifier
+ 33238736
+Title
+ Role of gender, age and BMI in prognosis of heart failure. [Review]
+Source
+ European Journal of Preventive Cardiology. 27(2_suppl):46-51, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sciomer S; Moscucci F; Salvioni E; Marchese G; Bussotti M; Corra U; Piepoli MF
+Authors Full Name
+ Sciomer, Susanna; Moscucci, Federica; Salvioni, Elisabetta; Marchese, Giovanni; Bussotti, Maurizio; Corra, Ugo; Piepoli, Massimo F.
+Institution
+ Sciomer, Susanna. Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, University of Rome 'Sapienza', Italy.
+ Moscucci, Federica. Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, University of Rome 'Sapienza', Italy.
+ Salvioni, Elisabetta. Centro Cardiologico Monzino, IRCCS, Italy.
+ Marchese, Giovanni. Department of Cardiology, Istituti Clinici Scientifici Maugeri SpA Societa Benefit, Italy.
+ Bussotti, Maurizio. Department of Cardiology, Istituti Clinici Scientifici Maugeri SpA Societa Benefit, Italy.
+ Corra, Ugo. Salvatore Maugeri Foundation, Institute for Clinical Care and Research (IRCCS), Italy.
+ Piepoli, Massimo F. Heart Failure Unit, G da Saliceto Hospital, Italy.
+ Piepoli, Massimo F. Institute of Life Sciences, Sant'Anna School of Advanced Studies, Italy.
+MeSH Subject Headings
+ Age Factors
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Decision Support Techniques
+ Echocardiography
+ Exercise Test
+ Female
+ Health Status Disparities
+ Heart Disease Risk Factors
+ *Heart Failure/di [Diagnosis]
+ Heart Failure/ep [Epidemiology]
+ Heart Failure/pp [Physiopathology]
+ Heart Failure/th [Therapy]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ Predictive Value of Tests
+ Prognosis
+ Reproducibility of Results
+ Risk Assessment
+ Sex Factors
+Keyword Heading
+ BMI
+ Gender
+ age
+ chronic heart failure
+ metabolic exercise cardiac kidney index (MECKI) score
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The prognostic stratification of heart failure remains an urgent need for correct clinical management of the affected patients. In fact, due to the high mortality and morbidity rates, heart failure constantly requires an updated and careful management of all aspects that characterise the disease. In addition to the well-known clinical, laboratory and instrumental characteristics that affect the prognosis of heart failure, gender, age and body mass index have a different impact and deserve specific insights and clarifications. At this scope, the metabolic exercise cardiac kidney index score research group has produced several works in the past, trying to identify the role of these specific factors on the prognosis of heart failure. In particular, the different performances in the cardiopulmonary exercise test of specific categories of heart failure patients, such as women, elderly and obese or overweight individuals, have requested dedicated evaluations of metabolic exercise cardiac kidney index score power.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1177%2f2047487320961980
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sciomer&issn=2047-4873&title=European+Journal+of+Preventive+Cardiology&atitle=Role+of+gender%2C+age+and+BMI+in+prognosis+of+heart+failure.&volume=27&issue=2&spage=46&epage=51&date=2020&doi=10.1177%2F2047487320961980&pmid=33238736&sid=OVID:medline
+
+<1131>
+Unique Identifier
+ 33208757
+Title
+ The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery.
+Source
+ Scientific Reports. 10(1):20128, 2020 11 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schulte F; Asbeutah AA; Benotti PN; Wood GC; Still C; Bistrian BR; Hardt M; Welty FK
+Authors Full Name
+ Schulte, Fabian; Asbeutah, Abdul Aziz; Benotti, Peter N; Wood, G Craig; Still, Christopher; Bistrian, Bruce R; Hardt, Markus; Welty, Francine K.
+Institution
+ Schulte, Fabian. Forsyth Institute, Cambridge, MA, USA.
+ Schulte, Fabian. Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA.
+ Asbeutah, Abdul Aziz. Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, SL 423, Boston, MA, 02215, USA.
+ Asbeutah, Abdul Aziz. Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Benotti, Peter N. Geisinger Obesity Institute, Danville, PA, USA.
+ Wood, G Craig. Geisinger Obesity Institute, Danville, PA, USA.
+ Still, Christopher. Geisinger Obesity Institute, Danville, PA, USA.
+ Bistrian, Bruce R. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
+ Hardt, Markus. Forsyth Institute, Cambridge, MA, USA.
+ Hardt, Markus. Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA.
+ Welty, Francine K. Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, SL 423, Boston, MA, 02215, USA. fwelty@bidmc.harvard.edu.
+MeSH Subject Headings
+ Aged
+ Bariatric Surgery
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Dinoprostone/bl [Blood]
+ Docosahexaenoic Acids/bl [Blood]
+ *Eicosanoids/bl [Blood]
+ Fatty Acids, Unsaturated/bl [Blood]
+ Female
+ Humans
+ Leukocyte Count
+ Lipid Metabolism
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity, Morbid/bl [Blood]
+ *Obesity, Morbid/su [Surgery]
+ Urachal Cyst/bl [Blood]
+ Weight Loss
+Abstract
+ Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)-resolvins (Rv), protectins (PD) and maresins (MaR)-actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinflammatory eicosanoid levels using liquid chromatography-tandem mass spectrometry in 29 morbidly obese subjects (13 with diabetes) and 15 nondiabetic, mildly obese subjects. Compared to the mildly obese, the morbidly obese had higher levels of SPMs-RvD3, RvD4 and PD1-and white blood cells (WBC) and platelets. Post-surgery, SPM and platelet levels decreased in morbidly obese nondiabetic subjects but not in diabetic subjects, suggesting continued inflammation. Despite similar weight reductions 1 year after surgery (44.6% vs. 46.6%), 8 diabetes remitters had significant reductions in WBC and platelet counts whereas five non-remitters did not. Remitters had a 58.2% decrease (p = 0.03) in 14-HDHA, a maresin pathway marker; non-remitters had an 875.7% increase in 14-HDHA but a 36.9% decrease in MaR1 to a median of 0. In conclusion, higher levels of RvD3, PD1 and their pathway marker, 17-HDHA, are markers of leukocyte activation and inflammation in morbid obesity and diabetes and diminish with weight loss in nondiabetic but not diabetic subjects, possibly representing sustained inflammation in the latter. Lack of diabetes remission after surgically-induced weight loss may be associated with reduced ability to produce MaR1 and sustained inflammation.
+Registry Number/Name of Substance
+ 0 (7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid). 0 (Biomarkers). 0 (Eicosanoids). 0 (Fatty Acids, Unsaturated). 0 (protectin D1). 0 (resolvin D3). 0 (resolvin D4). 25167-62-8 (Docosahexaenoic Acids). K7Q1JQR04M (Dinoprostone).
+Rare Disease Supplementary Concept
+ Benign non-infected urachal cyst
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-75353-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schulte&issn=2045-2322&title=Scientific+Reports&atitle=The+relationship+between+specialized+pro-resolving+lipid+mediators%2C+morbid+obesity+and+weight+loss+after+bariatric+surgery.&volume=10&issue=1&spage=20128&epage=&date=2020&doi=10.1038%2Fs41598-020-75353-6&pmid=33208757&sid=OVID:medline
+
+<1132>
+Unique Identifier
+ 33204721
+Title
+ A Nomogram Model Based on Noninvasive Bioindicators to Predict 3-Year Risk of Nonalcoholic Fatty Liver in Nonobese Mainland Chinese: A Prospective Cohort Study.
+Source
+ BioMed Research International. 2020:8852198, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cai X; Aierken X; Ahmat A; Cao Y; Zhu Q; Wu T; Li N
+Author NameID
+ Cai, Xintian; ORCID: https://orcid.org/0000-0003-3172-1540
+ Li, Nanfang; ORCID: https://orcid.org/0000-0003-1505-8566
+Authors Full Name
+ Cai, Xintian; Aierken, Xiayire; Ahmat, Ayguzal; Cao, Yuanyuan; Zhu, Qing; Wu, Ting; Li, Nanfang.
+Institution
+ Cai, Xintian. Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, China.
+ Aierken, Xiayire. Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, China.
+ Ahmat, Ayguzal. Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, China.
+ Cao, Yuanyuan. Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, China.
+ Zhu, Qing. Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, China.
+ Wu, Ting. Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, China.
+ Li, Nanfang. Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, China.
+MeSH Subject Headings
+ Asian People
+ *Biomarkers/bl [Blood]
+ Cost-Benefit Analysis
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Nomograms
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Obesity
+ Precision Medicine/mt [Methods]
+ Proportional Hazards Models
+ Prospective Studies
+ Reproducibility of Results
+ Risk Factors
+Abstract
+ The purpose of this study is to establish and validate an accurate and personalized nonalcoholic fatty liver disease (NAFLD) prediction model based on the nonobese population in China. This study is a secondary analysis of a prospective study. We included 6,155 nonobese adults without NAFLD at baseline, with a median follow-up of 2.3 years. Univariate and multivariate Cox regression analyses were used to determine independent predictors. The least absolute shrinkage and selection operator (LASSO) regression analysis was used to optimize the selection of variables. Based on the results of multivariate analysis, a prediction model was established. Harrell's consistency index (C-index) and area under the curve (AUC) were used to determine the discrimination of the proposed model. The goodness of fit of the calibration model was tested, and the clinical application value of the model was evaluated by decision curve analysis (DCA). The participants were randomly divided into a training cohort (n = 4,605) and a validation cohort (n = 1,550). Finally, seven of the variables (HDL-c, BMI, GGT, ALT, TB, DBIL, and TG) were included in the prediction model. In the training cohort, the C-index and AUC value of this prediction model were 0.832 (95% confidence interval (CI), 0.820-0.844) and 0.861 (95% CI, 0.849-0.873), respectively. In the validation cohort, the C-index and AUC values of this prediction model were 0.829 (95% CI, 0.806-0.852) and 0.859 (95% CI, 0.841-0.877), respectively. The calibration plots demonstrated good agreement between the estimated probability and the actual observation. DCA demonstrated a clinically effective predictive model. Our nomogram can be used as a simple, reasonable, economical, and widely used tool to predict the 3-year risk of NAFLD in nonobese populations in China, which is helpful for timely intervention and reducing the incidence of NAFLD. Copyright © 2020 Xintian Cai et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1155%2f2020%2f8852198
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cai&issn=2314-6141&title=BioMed+Research+International&atitle=A+Nomogram+Model+Based+on+Noninvasive+Bioindicators+to+Predict+3-Year+Risk+of+Nonalcoholic+Fatty+Liver+in+Nonobese+Mainland+Chinese%3A+A+Prospective+Cohort+Study.&volume=2020&issue=&spage=8852198&epage=&date=2020&doi=10.1155%2F2020%2F8852198&pmid=33204721&sid=OVID:medline
+
+<1133>
+Unique Identifier
+ 33202604
+Title
+ Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa.
+Source
+ Nutrients. 12(11), 2020 Nov 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mariani S; Di Giorgio MR; Rossi E; Tozzi R; Contini S; Bauleo L; Cipriani F; Toscano R; Basciani S; Barbaro G; Watanabe M; Valenti A; Cotugno A; Ancona C; Lubrano C; Gnessi L
+Author NameID
+ Mariani, Stefania; ORCID: https://orcid.org/0000-0003-1762-4701
+ Tozzi, Rossella; ORCID: https://orcid.org/0000-0002-3358-4204
+ Bauleo, Lisa; ORCID: https://orcid.org/0000-0002-2738-6180
+ Watanabe, Mikiko; ORCID: https://orcid.org/0000-0003-2225-8814
+ Ancona, Carla; ORCID: https://orcid.org/0000-0003-0081-0655
+Authors Full Name
+ Mariani, Stefania; Di Giorgio, Maria Rosaria; Rossi, Erica; Tozzi, Rossella; Contini, Savina; Bauleo, Lisa; Cipriani, Fiammetta; Toscano, Raffaella; Basciani, Sabrina; Barbaro, Giuseppe; Watanabe, Mikiko; Valenti, Agostino; Cotugno, Armando; Ancona, Carla; Lubrano, Carla; Gnessi, Lucio.
+Institution
+ Mariani, Stefania. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Di Giorgio, Maria Rosaria. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Rossi, Erica. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Tozzi, Rossella. Department of Molecular Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
+ Contini, Savina. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Bauleo, Lisa. Department of Epidemiology, Lazio Regional Health Service, 00147 Rome, Italy.
+ Cipriani, Fiammetta. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Toscano, Raffaella. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Basciani, Sabrina. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Barbaro, Giuseppe. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Watanabe, Mikiko. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Valenti, Agostino. Internal Medicine, Santo Spirito in Sassia Hospital, 00193 Rome, Italy.
+ Cotugno, Armando. Department of Mental Health, UOSD eating behavior disorders, Padiglione I, Comprensorio S. Maria della Pieta, 00135 Rome, Italy.
+ Ancona, Carla. Department of Epidemiology, Lazio Regional Health Service, 00147 Rome, Italy.
+ Lubrano, Carla. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+ Gnessi, Lucio. Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, Rome, Italy.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ *Adiponectin/bl [Blood]
+ Adolescent
+ Adult
+ *Anorexia Nervosa/bl [Blood]
+ Anorexia Nervosa/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Echocardiography, Doppler
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ Humans
+ Intra-Abdominal Fat/me [Metabolism]
+ Intra-Abdominal Fat/pp [Physiopathology]
+ *Leptin/bl [Blood]
+ Linear Models
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ Pericardium/pp [Physiopathology]
+ *Sirtuin 1/bl [Blood]
+ Young Adult
+Keyword Heading
+ adiponectin
+ adipose tissue
+ anorexia nervosa
+ leptin
+ obesity
+ plasma SIRT1
+ sirtuins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Sirtuin 1 (SIRT1) is a sensor of cell energy availability, and with leptin and adiponectin, it regulates metabolic homeostasis. Widely studied in tissues, SIRT1 is under evaluation as a plasmatic marker. We aimed at assessing whether circulating SIRT1 behaves consistently with leptin and adiponectin in conditions of deficiency, excess or normal fat content. Eighty subjects were evaluated: 27 with anorexia nervosa (AN), 26 normal-weight and 27 with obesity. Bloodstream SIRT1, leptin and adiponectin (ELISA), total and trunk fat mass (FM) %, abdominal visceral adipose tissue, liver steatosis and epicardial fat thickness (EFT) were assessed. For each fat store, the coefficient of determination (R2) was used to evaluate the prediction capability of SIRT1, leptin and adiponectin. Plasma SIRT1 and adiponectin coherently decreased with the increase of FM, while the opposite occurred with leptin. Mean levels of each analyte were different between groups (p < 0.005). A significant association between plasma variables and FM depots was observed. SIRT1 showed a good predictive strength for FM, particularly in the obesity group, where the best R2 was recorded for EFT (R2 = 0.7). Blood SIRT1, adiponectin and leptin behave coherently with FM and there is synchrony between them. The association of SIRT1 with FM is substantially superimposable to that of adiponectin and leptin. Given its homeostatic roles, SIRT1 may deserve to be considered as a plasma clinical/biochemical parameter of adiposity and metabolic health.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin). EC 3-5-1 (SIRT1 protein, human). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12113506
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mariani&issn=2072-6643&title=Nutrients&atitle=Blood+SIRT1+Shows+a+Coherent+Association+with+Leptin+and+Adiponectin+in+Relation+to+the+Degree+and+Distribution+of+Adiposity%3A+A+Study+in+Obesity%2C+Normal+Weight+and+Anorexia+Nervosa.&volume=12&issue=11&spage=&epage=&date=2020&doi=10.3390%2Fnu12113506&pmid=33202604&sid=OVID:medline
+
+<1134>
+Unique Identifier
+ 33199639
+Title
+ Lack of adipocyte purinergic P2Y6 receptor greatly improves whole body glucose homeostasis.
+Source
+ Proceedings of the National Academy of Sciences of the United States of America. 117(48):30763-30774, 2020 12 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jain S; Pydi SP; Toti KS; Robaye B; Idzko M; Gavrilova O; Wess J; Jacobson KA
+Author NameID
+ Jain, Shanu; ORCID: https://orcid.org/0000-0003-3110-1990
+ Pydi, Sai P; ORCID: https://orcid.org/0000-0001-7170-6519
+ Toti, Kiran S; ORCID: https://orcid.org/0000-0002-4528-4858
+ Jacobson, Kenneth A; ORCID: https://orcid.org/0000-0001-8104-1493
+Authors Full Name
+ Jain, Shanu; Pydi, Sai P; Toti, Kiran S; Robaye, Bernard; Idzko, Marco; Gavrilova, Oksana; Wess, Jurgen; Jacobson, Kenneth A.
+Institution
+ Jain, Shanu. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
+ Pydi, Sai P. Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
+ Toti, Kiran S. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
+ Robaye, Bernard. Institute of Interdisciplinary Research (IRIBHM), Universite Libre de Bruxelles, 6041 Gosselies, Belgium.
+ Idzko, Marco. Universitatsklinik fur Innere Medizin II, Klinische Abteilung fur Pulmologie, Medizinische Universitat, 1090 Vienna, Austria.
+ Idzko, Marco. Department of Pneumology, University Hospital Freiburg, 79106 Freiburg, Germany.
+ Gavrilova, Oksana. Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
+ Wess, Jurgen. Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
+ Jacobson, Kenneth A. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892; kennethj@niddk.nih.gov.
+MeSH Subject Headings
+ Adipocytes/de [Drug Effects]
+ *Adipocytes/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ Energy Metabolism
+ Gene Expression Regulation/de [Drug Effects]
+ *Glucose/me [Metabolism]
+ *Homeostasis
+ Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ JNK Mitogen-Activated Protein Kinases/me [Metabolism]
+ Mice
+ Mice, Knockout
+ Mitochondria/ge [Genetics]
+ Mitochondria/me [Metabolism]
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Receptors, Purinergic P2/ge [Genetics]
+ *Receptors, Purinergic P2/me [Metabolism]
+Keyword Heading
+ GPCR
+ adipocyte
+ metabolism
+ nucleotides
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Uridine diphosphate (UDP)-activated purinergic receptor P2Y6 (P2Y6R) plays a crucial role in controlling energy balance through central mechanisms. However, P2Y6R's roles in peripheral tissues regulating energy and glucose homeostasis remain unexplored. Here, we report the surprising finding that adipocyte-specific deletion of P2Y6R protects mice from diet-induced obesity, improving glucose tolerance and insulin sensitivity with reduced systemic inflammation. These changes were associated with reduced JNK signaling and enhanced expression and activity of PPARalpha affecting downstream PGC1alpha levels leading to beiging of white fat. In contrast, P2Y6R deletion in skeletal muscle reduced glucose uptake, resulting in impaired glucose homeostasis. Interestingly, whole body P2Y6R knockout mice showed metabolic improvements similar to those observed with mice lacking P2Y6R only in adipocytes. Our findings provide compelling evidence that P2Y6R antagonists may prove useful for the treatment of obesity and type 2 diabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Receptors, Purinergic P2). 0 (purinoceptor P2Y6). EC 2-7-11-24 (JNK Mitogen-Activated Protein Kinases). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1073%2fpnas.2006578117
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jain&issn=0027-8424&title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&atitle=Lack+of+adipocyte+purinergic+P2Y6+receptor+greatly+improves+whole+body+glucose+homeostasis.&volume=117&issue=48&spage=30763&epage=30774&date=2020&doi=10.1073%2Fpnas.2006578117&pmid=33199639&sid=OVID:medline
+
+<1135>
+Unique Identifier
+ 33198735
+Title
+ Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity.
+Source
+ BMC Endocrine Disorders. 20(1):171, 2020 Nov 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Taheri E; Hosseini S; Qorbani M; Mirmiran P
+Authors Full Name
+ Taheri, Ehsaneh; Hosseini, Saeed; Qorbani, Mostafa; Mirmiran, Parvin.
+Institution
+ Taheri, Ehsaneh. Student Research Committee, Shahid Beheshti University of Medical Sciences, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran. ehsaneh_taheri@yahoo.com.
+ Hosseini, Saeed. Department of Clinical Nutrition, School of Nutritional Scientists and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Qorbani, Mostafa. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
+ Mirmiran, Parvin. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. parven.mirmirran@gmail.com.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adult
+ *Biomarkers/an [Analysis]
+ *Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Body Weight
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Iran/ep [Epidemiology]
+ *Leptin/bl [Blood]
+ *Lipids/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Obesity/pa [Pathology]
+ Prognosis
+ Young Adult
+Keyword Heading
+ Adipokines
+ Glycemic profile, lipid profile
+ Normal weight obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.
+
+ METHODS: Forty women with body mass index (BMI) = 18.5-24.9 kg/m2 and fat mass (FM) >= 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured.
+
+ RESULTS: The mean +/- standard deviation (SD) age of participants was 28.76 +/- 4.76 years in the NWO group and 29.23 +/- 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 +/- 4.75 vs. 6.24 +/- 2.51, P = 0.009), leptin (17.31 +/- 8.10 vs. 9.94 +/- 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 +/- 20.71 vs. 23.48 +/- 10.03, P = 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06), positively.
+
+ CONCLUSION: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Leptin). 0 (Lipids). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12902-020-00648-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Taheri&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Association+of+adipocytokines+with+lipid+and+glycemic+profiles+in+women+with+normal+weight+obesity.&volume=20&issue=1&spage=171&epage=&date=2020&doi=10.1186%2Fs12902-020-00648-8&pmid=33198735&sid=OVID:medline
+
+<1136>
+Unique Identifier
+ 33193441
+Title
+ Interaction of Adipocyte Metabolic and Immune Functions Through TBK1. [Review]
+Source
+ Frontiers in Immunology. 11:592949, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhao P; Saltiel AR
+Authors Full Name
+ Zhao, Peng; Saltiel, Alan R.
+Institution
+ Zhao, Peng. Department of Medicine, University of California San Diego, La Jolla, CA, United States.
+ Saltiel, Alan R. Department of Medicine, University of California San Diego, La Jolla, CA, United States.
+ Saltiel, Alan R. Department of Pharmacology, University of California San Diego, La Jolla, CA, United States.
+MeSH Subject Headings
+ *Adipocytes/im [Immunology]
+ *Adipocytes/me [Metabolism]
+ Adipose Tissue/im [Immunology]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Disease Susceptibility
+ *Energy Metabolism
+ Humans
+ *Immunomodulation
+ Metabolic Diseases/et [Etiology]
+ Metabolic Diseases/me [Metabolism]
+ Metabolic Diseases/pa [Pathology]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Protein Serine-Threonine Kinases/ge [Genetics]
+ *Protein Serine-Threonine Kinases/me [Metabolism]
+ Signal Transduction
+Keyword Heading
+ IKK
+ TBK1
+ adipose tissue
+ inflammation
+ metabolism
+ obesity
+ overnutrition
+ undernutrition
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipocytes and adipose tissue play critical roles in the regulation of metabolic homeostasis. In obesity and obesity-associated metabolic diseases, immune cells infiltrate into adipose tissues. Interaction between adipocytes and immune cells re-shapes both metabolic and immune properties of adipose tissue and dramatically changes metabolic set points. Both the expression and activity of the non-canonical IKK family member TBK1 are induced in adipose tissues during diet-induced obesity. TBK1 plays important roles in the regulation of both metabolism and inflammation in adipose tissue and thus affects glucose and energy metabolism. Here we review the regulation and functions of TBK1 and the molecular mechanisms by which TBK1 regulates both metabolism and inflammation in adipose tissue. Finally, we discuss the potential of a TBK1/IKKepsilon inhibitor as a new therapy for metabolic diseases. Copyright © 2020 Zhao and Saltiel.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-7-11-1 (Protein Serine-Threonine Kinases). EC 2-7-11-1 (TBK1 protein, human).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffimmu.2020.592949
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhao&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Interaction+of+Adipocyte+Metabolic+and+Immune+Functions+Through+TBK1.&volume=11&issue=&spage=592949&epage=&date=2020&doi=10.3389%2Ffimmu.2020.592949&pmid=33193441&sid=OVID:medline
+
+<1137>
+Unique Identifier
+ 33182462
+Title
+ An Overview of the Role of Adipokines in Cardiometabolic Diseases. [Review]
+Source
+ Molecules. 25(21), 2020 Nov 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Farkhondeh T; Llorens S; Pourbagher-Shahri AM; Ashrafizadeh M; Talebi M; Shakibaei M; Samarghandian S
+Author NameID
+ Llorens, Silvia; ORCID: https://orcid.org/0000-0002-2104-5414
+ Pourbagher-Shahri, Ali Mohammad; ORCID: https://orcid.org/0000-0003-4462-9890
+ Ashrafizadeh, Milad; ORCID: https://orcid.org/0000-0001-6605-822X
+ Talebi, Marjan; ORCID: https://orcid.org/0000-0001-5513-3204
+ Shakibaei, Mehdi; ORCID: https://orcid.org/0000-0002-6304-7506
+ Samarghandian, Saeed; ORCID: https://orcid.org/0000-0001-5461-9579
+Authors Full Name
+ Farkhondeh, Tahereh; Llorens, Silvia; Pourbagher-Shahri, Ali Mohammad; Ashrafizadeh, Milad; Talebi, Marjan; Shakibaei, Mehdi; Samarghandian, Saeed.
+Institution
+ Farkhondeh, Tahereh. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand 9717853577, Iran.
+ Farkhondeh, Tahereh. Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand 9717853577, Iran.
+ Llorens, Silvia. Department of Medical Sciences, Faculty of Medicine of Albacete, Centro Regional de Investigaciones Biomedicas (CRIB), University of Castilla-La Mancha, 02008 Albacete, Spain.
+ Pourbagher-Shahri, Ali Mohammad. Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand 9717853577, Iran.
+ Ashrafizadeh, Milad. Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Universite Caddesi No. 27, Orhanli, Tuzla, Istanbul 34956, Turkey.
+ Ashrafizadeh, Milad. Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul 34956, Turkey.
+ Talebi, Marjan. Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1996835113, Iran.
+ Shakibaei, Mehdi. Musculoskeletal Research Group and Tumour Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, Germany.
+ Samarghandian, Saeed. Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur 9318614139, Iran.
+MeSH Subject Headings
+ *Adipokines/me [Metabolism]
+ *Adiponectin/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ *Cardiovascular Diseases/me [Metabolism]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Genome
+ Humans
+ Inflammation
+ *Leptin/me [Metabolism]
+ Metabolic Syndrome/me [Metabolism]
+ Obesity/me [Metabolism]
+ *Resistin/me [Metabolism]
+ Risk Factors
+Keyword Heading
+ adipokines
+ cardiovascular disease
+ metabolic diseases
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity as an independent risk factor for cardiovascular diseases (CVDs) leads to an increase in morbidity, mortality, and a shortening of life span. The changes in heart structure and function as well as metabolic profile are caused by obese people, including those free of metabolic disorders. Obesity alters heart function structure and affects lipid and glucose metabolism, blood pressure, and increase inflammatory cytokines. Adipokines, specific cytokines of adipocytes, are involved in the progression of obesity and the associated co-morbidities. In the current study, we review the scientific evidence on the effects of obesity on CVDs, focusing on the changes in adipokines. Several adipokines have anti-inflammatory and cardioprotective effects comprising omentin, apelin, adiponectin, and secreted frizzled-related protein (Sfrp-5). Other adipokines have pro-inflammatory impacts on the cardiovascular system and obesity including leptin, tumor necrosis factor (TNF), retinol-binding protein4 (RBP-4), visfatin, resistin, and osteopontin. We found that obesity is associated with multiple CVDs, but can only occur in unhealthy metabolic patients. However, more studies should be designed to clarify the association between obesity, adipokine changes, and the occurrence of CVDs.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin). 0 (Resistin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fmolecules25215218
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Farkhondeh&issn=1420-3049&title=Molecules&atitle=An+Overview+of+the+Role+of+Adipokines+in+Cardiometabolic+Diseases.&volume=25&issue=21&spage=5218&epage=&date=2020&doi=10.3390%2Fmolecules25215218&pmid=33182462&sid=OVID:medline
+
+<1138>
+Unique Identifier
+ 33172464
+Title
+ Body mass index and cardiovascular outcomes in patients with acute coronary syndrome by diabetes status: the obesity paradox in a Korean national cohort study.
+Source
+ Cardiovascular Diabetology. 19(1):191, 2020 11 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Park SJ; Ha KH; Kim DJ
+Authors Full Name
+ Park, Se-Jun; Ha, Kyoung Hwa; Kim, Dae Jung.
+Institution
+ Park, Se-Jun. Division of Cardiology, Department of Internal Medicine, GangNeung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
+ Park, Se-Jun. Department of Cardiology, Armed Forces Capital Hospital, Seongnam, Korea.
+ Ha, Kyoung Hwa. Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon, 16499, Korea.
+ Ha, Kyoung Hwa. Ajou University School of Medicine, Cardiovascular and Metabolic Disease Etiology Research Center, Suwon, Korea.
+ Kim, Dae Jung. Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon, 16499, Korea. djkim@ajou.ac.kr.
+ Kim, Dae Jung. Ajou University School of Medicine, Cardiovascular and Metabolic Disease Etiology Research Center, Suwon, Korea. djkim@ajou.ac.kr.
+MeSH Subject Headings
+ Acute Coronary Syndrome/di [Diagnosis]
+ *Acute Coronary Syndrome/ep [Epidemiology]
+ Acute Coronary Syndrome/mo [Mortality]
+ Acute Coronary Syndrome/th [Therapy]
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ Comorbidity
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/dt [Drug Therapy]
+ *Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Heart Failure/ep [Epidemiology]
+ Humans
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Life Style
+ Male
+ Middle Aged
+ Myocardial Infarction/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Obesity/mo [Mortality]
+ Prognosis
+ Protective Factors
+ Republic of Korea/ep [Epidemiology]
+ Risk Assessment
+ Risk Factors
+ Stroke/ep [Epidemiology]
+ Time Factors
+Keyword Heading
+ Acute coronary syndrome
+ Diabetes mellitus
+ Obesity
+ Obesity paradox
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The "obesity paradox" has not been elucidated in the long-term outcomes of acute coronary syndrome (ACS). We investigated the association between obesity and cardiovascular (CV) outcomes in ACS patients with and without diabetes.
+
+ METHODS: We identified 6978 patients with ACS aged 40-79 years from the Korean National Health Insurance Service-Health Screening Cohort between 2002 and 2015. Baseline body mass index (BMI) was categorized as underweight (< 18.5 kg/m2), normal weight (18.5-22.9 kg/m2), overweight (23.0-24.9 kg/m2), obese class I (25.0-29.9 kg/m2), and obese class II (>= 30.0 kg/m2). The primary outcome was major adverse CV events (MACE)-CV death, myocardial infarction (MI), and stroke. The secondary outcomes were the individual components of MACE, hospitalization for heart failure (HHF), and all-cause death.
+
+ RESULTS: After adjustment for confounding variables, compared to normal-weight patients without diabetes (reference group), obese class I patients with and without diabetes had a lower risk of MACE, but only significant in patients without diabetes (with diabetes: hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.78-1.14; without diabetes: HR 0.78, 95% CI 0.62-0.97). Obese class II patient with diabetes had a higher risk of MACE with no statistical significance (HR 1.14, 95% CI 0.82-1.59). Underweight patients with and without diabetes had a higher risk of MACE, but only significant in patients with diabetes (with diabetes: HR 1.79, 95% CI 1.24-2.58; without diabetes: HR 1.23, 95% CI 0.77-1.97).
+
+ CONCLUSION: In ACS patients, obesity had a protective effect on CV outcomes, especially in patients without diabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hypoglycemic Agents).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12933-020-01170-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Park&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Body+mass+index+and+cardiovascular+outcomes+in+patients+with+acute+coronary+syndrome+by+diabetes+status%3A+the+obesity+paradox+in+a+Korean+national+cohort+study.&volume=19&issue=1&spage=191&epage=&date=2020&doi=10.1186%2Fs12933-020-01170-w&pmid=33172464&sid=OVID:medline
+
+<1139>
+Unique Identifier
+ 33171599
+Title
+ Dietary Patterns and Their Association with Body Composition and Cardiometabolic Markers in Children and Adolescents: Genobox Cohort.
+Source
+ Nutrients. 12(11), 2020 Nov 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Latorre-Millan M; Ruperez AI; Gonzalez-Gil EM; Santaliestra-Pasias A; Vazquez-Cobela R; Gil-Campos M; Aguilera CM; Gil A; Moreno LA; Leis R; Bueno G
+Author NameID
+ Latorre-Millan, Miriam; ORCID: https://orcid.org/0000-0001-9932-0124
+ Ruperez, Azahara I; ORCID: https://orcid.org/0000-0002-3850-8235
+ Gil-Campos, Mercedes; ORCID: https://orcid.org/0000-0002-9007-0242
+ Aguilera, Concepcion M; ORCID: https://orcid.org/0000-0002-1451-4788
+ Gil, Angel; ORCID: https://orcid.org/0000-0001-7663-0939
+ Moreno, Luis A; ORCID: https://orcid.org/0000-0003-0454-653X
+ Leis, Rosaura; ORCID: https://orcid.org/0000-0002-0540-4210
+Authors Full Name
+ Latorre-Millan, Miriam; Ruperez, Azahara I; Gonzalez-Gil, Esther M; Santaliestra-Pasias, Alba; Vazquez-Cobela, Rocio; Gil-Campos, Mercedes; Aguilera, Concepcion M; Gil, Angel; Moreno, Luis A; Leis, Rosaura; Bueno, Gloria.
+Institution
+ Latorre-Millan, Miriam. GENUD Research group, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Universidad de Zaragoza, 50013 Zaragoza, Spain.
+ Latorre-Millan, Miriam. Unidad de Endocrinologia Pediatrica, Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Spain.
+ Ruperez, Azahara I. GENUD Research group, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Universidad de Zaragoza, 50013 Zaragoza, Spain.
+ Ruperez, Azahara I. Instituto Agroalimentario de Aragon (IA2), Zaragoza, Spain.
+ Gonzalez-Gil, Esther M. GENUD Research group, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Universidad de Zaragoza, 50013 Zaragoza, Spain.
+ Gonzalez-Gil, Esther M. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Gonzalez-Gil, Esther M. Departamento de Bioquimica y Biologia Molecular II, Instituto de Nutricion y Tecnologia de los Alimentos, Centro de Investigacion Biomedica, Universidad de Granada, 18016 Granada, Spain.
+ Santaliestra-Pasias, Alba. GENUD Research group, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Universidad de Zaragoza, 50013 Zaragoza, Spain.
+ Santaliestra-Pasias, Alba. Instituto Agroalimentario de Aragon (IA2), Zaragoza, Spain.
+ Santaliestra-Pasias, Alba. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Vazquez-Cobela, Rocio. Unidad de Gastroenterologia, Hepatologia y Nutricion Pediatrica, Grupo de Investigacion Nutricion Pediatrica, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain.
+ Gil-Campos, Mercedes. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Gil-Campos, Mercedes. Unidad de Metabolismo e Investigacion Pediatrica, Hospital Universitario Reina Sofia, Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), 14071 Cordoba, Spain.
+ Aguilera, Concepcion M. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Aguilera, Concepcion M. Departamento de Bioquimica y Biologia Molecular II, Instituto de Nutricion y Tecnologia de los Alimentos, Centro de Investigacion Biomedica, Universidad de Granada, 18016 Granada, Spain.
+ Aguilera, Concepcion M. Instituto de Investigacion Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain.
+ Gil, Angel. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Gil, Angel. Departamento de Bioquimica y Biologia Molecular II, Instituto de Nutricion y Tecnologia de los Alimentos, Centro de Investigacion Biomedica, Universidad de Granada, 18016 Granada, Spain.
+ Gil, Angel. Instituto de Investigacion Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain.
+ Moreno, Luis A. GENUD Research group, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Universidad de Zaragoza, 50013 Zaragoza, Spain.
+ Moreno, Luis A. Instituto Agroalimentario de Aragon (IA2), Zaragoza, Spain.
+ Moreno, Luis A. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Leis, Rosaura. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+ Leis, Rosaura. Unidad de Gastroenterologia, Hepatologia y Nutricion Pediatrica, Grupo de Investigacion Nutricion Pediatrica, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain.
+ Leis, Rosaura. Unidad de Investigacion en Nutricion, Crecimiento y Desarrollo Humano de Galicia (GALINUT), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
+ Bueno, Gloria. GENUD Research group, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Universidad de Zaragoza, 50013 Zaragoza, Spain.
+ Bueno, Gloria. Unidad de Endocrinologia Pediatrica, Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Spain.
+ Bueno, Gloria. Instituto Agroalimentario de Aragon (IA2), Zaragoza, Spain.
+ Bueno, Gloria. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/me [Metabolism]
+ *Body Composition
+ Body Mass Index
+ Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Child
+ Cohort Studies
+ *Feeding Behavior
+ Female
+ Humans
+ Male
+ Metabolic Syndrome/co [Complications]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Spain/ep [Epidemiology]
+ Surveys and Questionnaires
+Keyword Heading
+ anthropometry
+ cardiovascular disease
+ cluster analysis
+ diet
+ inflammation
+ obesity
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Diet is a key factor for obesity development; however, limited data are available on dietary cluster analysis in children with obesity. We aimed to assess the associations between dietary patterns and obesity and several cardiometabolic markers. Anthropometry, bioelectrical impedance, blood pressure and plasma biomarkers of oxidative stress, inflammation and endothelial damage were determined in 674 Caucasian children, aged 5-16, with normal or excess weight. Using a food frequency questionnaire and cluster analysis, two consistent dietary patterns were shown, labeled as health conscious (HC) and sweet and processed (SP). The HC pattern included a greater proportion of participants with overweight/obesity than the SP cluster (80.1% vs. 63.8%). However, children with obesity within the HC cluster, showed less abdominal fat, through waist to hip (0.93 vs. 0.94) and waist to height (0.61 vs. 0.63) indexes (p < 0.01). Univariate general models showed several additional differences in cardiometabolic risk biomarkers in the global and stratified analyses, with a healthier profile being observed mainly in the HC cluster. However, multivariate models questioned these findings and pointed out the need for further studies in this field. Anyhow, our findings support the benefits of a healthy diet and highlight the importance of dietary patterns in the cardiometabolic risk assessment of children with overweight/obesity, beyond weight control.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12113424
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Latorre-Millan&issn=2072-6643&title=Nutrients&atitle=Dietary+Patterns+and+Their+Association+with+Body+Composition+and+Cardiometabolic+Markers+in+Children+and+Adolescents%3A+Genobox+Cohort.&volume=12&issue=11&spage=&epage=&date=2020&doi=10.3390%2Fnu12113424&pmid=33171599&sid=OVID:medline
+
+<1140>
+Unique Identifier
+ 33169810
+Title
+ A comparative study evaluating C-reactive protein, sputum eosinophils and forced expiratory volume in one second in obese and nonobese asthmatics.
+Source
+ Advances in Respiratory Medicine. 88(5):394-399, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mahender H; Amarnath R; Vadivelu S
+Author NameID
+ Mahender, Harish; ORCID: https://orcid.org/0000-0002-7625-7908
+Authors Full Name
+ Mahender, Harish; Amarnath, Raja; Vadivelu, Sreenivasan.
+Institution
+ Mahender, Harish. Department of Respiratory Medicine, Sree Balaji Medical College and Hospital, Bharath University, Chromepet, Chennai, India. drmharish@gmail.com.
+ Amarnath, Raja. Department of Respiratory Medicine, Sree Balaji Medical College and Hospital, Bharath University, Chromepet, Chennai, India.
+ Vadivelu, Sreenivasan. Department of Respiratory Medicine, Sree Balaji Medical College and Hospital, Bharath University, Chromepet, Chennai, India.
+MeSH Subject Headings
+ Asthma/co [Complications]
+ Asthma/di [Diagnosis]
+ *Asthma
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ *C-Reactive Protein
+ Case-Control Studies
+ *Eosinophils
+ *Forced Expiratory Volume
+ Humans
+ Inflammation
+ Leukocyte Count
+ Obesity/co [Complications]
+ *Obesity
+ Respiratory Function Tests
+ Sputum
+Keyword Heading
+ C-reactive protein
+ FEV1
+ obese asthmatics
+ sputum eosinophils
+ systemic inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ ntroduction: Asthma and obesity are considered inflammatory disorders. Inflammatory markers - sputum eosinophils, C-reactive protein (CRP) and the forced expiratory volume in one second (FEV1) were analysed to find their association in obese asthmatics and compared with their asthma control test (ACT) to understand these parameters in this phenotype.
+
+ MATERIAL AND METHODS: After completing the asthma control test (ACT), the CRP, FEV1 and sputum eosinophils of sixty asthmatics were compared to find the association of them in obese and nonobese asthmatics and contrasted with their ACT. The data were analysed using IBM SPSS V20.0, Mann-Whitney U test (non-parametric test), Pearson's correlation coefficient and Fisher's exact test.
+
+ RESULTS: We found significant differences for CRP (P = 0.001) and sputum eosinophils (P = 0.001) between obese and nonobese asthmatics, both higher in obese asthmatics and with a significant association with body mass index (BMI) (P < 0.05). The FEV1 levels were independent of the BMI levels of asthmatics. There was a significant correlation between the CRP and sputum eosin-ophils (0.52, P = 0.001) for all asthmatics. There was no significant correlation between FEV1 and sputum eosinophils (nonobese P = 0.120, obese P = 0.388) and between FEV1 and CRP (obese P = 0.423, nonobese P = 0.358) in both obese and nonobese asthmatics. Obesity had an association (P = 0.001) with ACT scores (<= 19).
+
+ CONCLUSIONS: Sputum eosinophils and CRP were raised in obese asthmatics and had a positive association with BMI. Obese asthmatics had a poorer subjective asthma control than nonobese asthmatics despite FEV1 being independent of the BMI levels. Measuring the systemic inflammatory markers could help in additional interventions in reducing systemic inflammation and thus possibly facilitating better symptom control.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.5603%2fARM.a2020.0155
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mahender&issn=2451-4934&title=Advances+in+Respiratory+Medicine&atitle=A+comparative+study+evaluating+C-reactive+protein%2C+sputum+eosinophils+and+forced+expiratory+volume+in+one+second+in+obese+and+nonobese+asthmatics.&volume=88&issue=5&spage=394&epage=399&date=2020&doi=10.5603%2FARM.a2020.0155&pmid=33169810&sid=OVID:medline
+
+<1141>
+Unique Identifier
+ 33167521
+Title
+ Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression. [Review]
+Source
+ International Journal of Molecular Sciences. 21(21), 2020 Nov 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chang ML; Yang Z; Yang SS
+Author NameID
+ Chang, Ming-Ling; ORCID: https://orcid.org/0000-0003-4902-4401
+Authors Full Name
+ Chang, Ming-Ling; Yang, Zinger; Yang, Sien-Sing.
+Institution
+ Chang, Ming-Ling. Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan.
+ Chang, Ming-Ling. Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
+ Yang, Zinger. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
+ Yang, Sien-Sing. Liver Center, Cathay General Hospital Medical Center, Taipei 10630, Taiwan.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ *Adipokines/me [Metabolism]
+ *Adipokines/ph [Physiology]
+ Adiponectin/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Digestive System/me [Metabolism]
+ Digestive System/pa [Pathology]
+ *Digestive System Diseases/me [Metabolism]
+ Digestive System Diseases/pp [Physiopathology]
+ Homeostasis
+ Humans
+ Inflammation/me [Metabolism]
+ Leptin/me [Metabolism]
+ Liver/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/me [Metabolism]
+Keyword Heading
+ HBV
+ HCV
+ NAFLD
+ adipokine
+ adiponectin
+ biliary
+ colon
+ esophagus
+ gallbladder
+ leptin
+ pancreas
+ small intestine
+ stomach
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipose tissue is a highly dynamic endocrine tissue and constitutes a central node in the interorgan crosstalk network through adipokines, which cause pleiotropic effects, including the modulation of angiogenesis, metabolism, and inflammation. Specifically, digestive cancers grow anatomically near adipose tissue. During their interaction with cancer cells, adipocytes are reprogrammed into cancer-associated adipocytes and secrete adipokines to affect tumor cells. Moreover, the liver is the central metabolic hub. Adipose tissue and the liver cooperatively regulate whole-body energy homeostasis via adipokines. Obesity, the excessive accumulation of adipose tissue due to hyperplasia and hypertrophy, is currently considered a global epidemic and is related to low-grade systemic inflammation characterized by altered adipokine regulation. Obesity-related digestive diseases, including gastroesophageal reflux disease, Barrett's esophagus, esophageal cancer, colon polyps and cancer, non-alcoholic fatty liver disease, viral hepatitis-related diseases, cholelithiasis, gallbladder cancer, cholangiocarcinoma, pancreatic cancer, and diabetes, might cause specific alterations in adipokine profiles. These patterns and associated bases potentially contribute to the identification of prognostic biomarkers and therapeutic approaches for the associated digestive diseases. This review highlights important findings about altered adipokine profiles relevant to digestive diseases, including hepatic, pancreatic, gastrointestinal, and biliary tract diseases, with a perspective on clinical implications and mechanistic explorations.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21218308
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chang&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Roles+of+Adipokines+in+Digestive+Diseases%3A+Markers+of+Inflammation%2C+Metabolic+Alteration+and+Disease+Progression.&volume=21&issue=21&spage=8308&epage=&date=2020&doi=10.3390%2Fijms21218308&pmid=33167521&sid=OVID:medline
+
+<1142>
+Unique Identifier
+ 33164985
+Title
+ Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity.
+Source
+ Journal of Clinical Investigation. 130(12):6688-6699, 2020 12 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cifarelli V; Beeman SC; Smith GI; Yoshino J; Morozov D; Beals JW; Kayser BD; Watrous JD; Jain M; Patterson BW; Klein S
+Authors Full Name
+ Cifarelli, Vincenza; Beeman, Scott C; Smith, Gordon I; Yoshino, Jun; Morozov, Darya; Beals, Joseph W; Kayser, Brandon D; Watrous, Jeramie D; Jain, Mohit; Patterson, Bruce W; Klein, Samuel.
+Institution
+ Cifarelli, Vincenza. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, and.
+ Beeman, Scott C. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, and.
+ Beeman, Scott C. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
+ Smith, Gordon I. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, and.
+ Yoshino, Jun. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, and.
+ Morozov, Darya. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
+ Beals, Joseph W. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, and.
+ Kayser, Brandon D. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, and.
+ Watrous, Jeramie D. Departments of Medicine and Pharmacology, University of California, San Diego, La Jolla, California, USA.
+ Jain, Mohit. Departments of Medicine and Pharmacology, University of California, San Diego, La Jolla, California, USA.
+ Patterson, Bruce W. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, and.
+ Klein, Samuel. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, and.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Amino Acids, Branched-Chain/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Female
+ Gene Expression Regulation
+ Humans
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ *Insulin Resistance
+ Male
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ *Oxygen/me [Metabolism]
+ *Subcutaneous Fat/me [Metabolism]
+ Subcutaneous Fat/pa [Pathology]
+Keyword Heading
+ Adipose tissue
+ Glucose metabolism
+ Metabolism
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUNDData from studies conducted in rodent models have shown that decreased adipose tissue (AT) oxygenation is involved in the pathogenesis of obesity-induced insulin resistance. Here, we evaluated the potential influence of AT oxygenation on AT biology and insulin sensitivity in people. METHODS We evaluated subcutaneous AT oxygen partial pressure (pO2); liver and whole-body insulin sensitivity; AT expression of genes and pathways involved in inflammation, fibrosis, and branched-chain amino acid (BCAA) catabolism; systemic markers of inflammation; and plasma BCAA concentrations, in 3 groups of participants that were rigorously stratified by adiposity and insulin sensitivity: metabolically healthy lean (MHL; n = 11), metabolically healthy obese (MHO; n = 15), and metabolically unhealthy obese (MUO; n = 20). RESULTS AT pO2 progressively declined from the MHL to the MHO to the MUO group, and was positively associated with hepatic and whole-body insulin sensitivity. AT pO2 was positively associated with the expression of genes involved in BCAA catabolism, in conjunction with an inverse relationship between AT pO2 and plasma BCAA concentrations. AT pO2 was negatively associated with AT gene expression of markers of inflammation and fibrosis. Plasma PAI-1 increased from the MHL to the MHO to the MUO group and was negatively correlated with AT pO2, whereas the plasma concentrations of other cytokines and chemokines were not different among the MHL and MUO groups. CONCLUSION These results support the notion that reduced AT oxygenation in individuals with obesity contributes to insulin resistance by increasing plasma PAI-1 concentrations and decreasing AT BCAA catabolism and thereby increasing plasma BCAA concentrations.TRIAL REGISTRATIONClinicalTrials.gov NCT02706262.FUNDINGThis study was supported by NIH grants K01DK109119, T32HL130357, K01DK116917, R01ES027595, P42ES010337, DK56341 (Nutrition Obesity Research Center), DK20579 (Diabetes Research Center), DK052574 (Digestive Disease Research Center), and UL1TR002345 (Clinical and Translational Science Award); NIH Shared Instrumentation Grants S10RR0227552, S10OD020025, and S10OD026929; and the Foundation for Barnes-Jewish Hospital.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers). S88TT14065 (Oxygen).
+Publication Type
+ Clinical Trial. Journal Article. Multicenter Study. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1172%2fJCI141828
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cifarelli&issn=0021-9738&title=Journal+of+Clinical+Investigation&atitle=Decreased+adipose+tissue+oxygenation+associates+with+insulin+resistance+in+individuals+with+obesity.&volume=130&issue=12&spage=6688&epage=6699&date=2020&doi=10.1172%2FJCI141828&pmid=33164985&sid=OVID:medline
+
+<1143>
+Unique Identifier
+ 33163057
+Title
+ Weight reduction improves immune system and inflammatory cytokines in obese asthmatic patients.
+Source
+ African Health Sciences. 20(2):897-902, 2020 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Sharif FM; Abd El-Kader SM; Neamatallah ZA; AlKhateeb AM
+Authors Full Name
+ Al-Sharif, Fadwah M; Abd El-Kader, Shehab M; Neamatallah, Ziyad A; AlKhateeb, Afnan M.
+Institution
+ Al-Sharif, Fadwah M. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Abd El-Kader, Shehab M. Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Neamatallah, Ziyad A. Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+ AlKhateeb, Afnan M. Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+MeSH Subject Headings
+ Adult
+ Asthma/bl [Blood]
+ Asthma/di [Diagnosis]
+ *Asthma/im [Immunology]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ *Cytokines/bl [Blood]
+ *Diet, Reducing
+ *Exercise
+ Female
+ Flow Cytometry
+ Humans
+ Immune System
+ Inflammation/bl [Blood]
+ Inflammation/co [Complications]
+ Inflammation/im [Immunology]
+ Interleukin-6/me [Metabolism]
+ Interleukin-8/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/im [Immunology]
+ *Obesity/th [Therapy]
+ *Systemic Inflammatory Response Syndrome/im [Immunology]
+ Treatment Outcome
+ *Weight Loss/im [Immunology]
+ Weight Reduction Programs
+Keyword Heading
+ Bronchial asthma
+ cytokines
+ immune system
+ obesity
+ weight reduction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Activation of immunological and systemic inflammation markers are common in obesity and asthma.
+
+ OBJECTIVE: The target of this study was to assess impact of weight reduction on immunological and systemic inflammation markers in obese asthma patients.
+
+ MATERIAL AND METHODS: Eighty asthmatic patients of both sex; their age and body mass index (BMI) mean were 38.72 +/- 7.14 year and 32.65 +/- 3.18 Kg/m2 respectively. Exclusion criteria included smokers, infections, vaccinations, cancer, surgery, immune system disorders and medications that may influence immune system function as anti-inflammatory medications, analgesics and anti-depressant. All subjects were randomly enrolled in weight reduction group (group A) or control group (group B).
+
+ RESULTS: The main findings in the present study indicated that weight reducing program in group (A) was associated with significant reduction in the mean values of IL6, TNF-alpha, and IL8 in addition to significant increase in the mean values of CD4 and CD8 cell count . However, findings of group (B) showed no significant changes. Moreover, Comparison between both groups at the end of the study revealed significant differences.
+
+ CONCLUSION: Weight reduction improved immunological and systemic inflammation markers in obese asthma patients. Copyright © 2020 Al-Sharif FM et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Interleukin-6). 0 (Interleukin-8).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.4314%2fahs.v20i2.44
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Sharif&issn=1680-6905&title=African+Health+Sciences&atitle=Weight+reduction+improves+immune+system+and+inflammatory+cytokines+in+obese+asthmatic+patients.&volume=20&issue=2&spage=897&epage=902&date=2020&doi=10.4314%2Fahs.v20i2.44&pmid=33163057&sid=OVID:medline
+
+<1144>
+Unique Identifier
+ 33149195
+Title
+ Abdominal subcutaneous fat quantification in obese patients from limited field-of-view MRI data.
+Source
+ Scientific Reports. 10(1):19039, 2020 11 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Michel S; Linder N; Eggebrecht T; Schaudinn A; Bluher M; Dietrich A; Denecke T; Busse H
+Authors Full Name
+ Michel, Sophia; Linder, Nicolas; Eggebrecht, Tobias; Schaudinn, Alexander; Bluher, Matthias; Dietrich, Arne; Denecke, Timm; Busse, Harald.
+Institution
+ Michel, Sophia. Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
+ Linder, Nicolas. Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
+ Linder, Nicolas. Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, 04103, Leipzig, Germany.
+ Eggebrecht, Tobias. Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
+ Eggebrecht, Tobias. Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, 04103, Leipzig, Germany.
+ Schaudinn, Alexander. Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, 04103, Leipzig, Germany.
+ Bluher, Matthias. Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
+ Bluher, Matthias. Department of Internal Medicine, Neurology and Dermatology, Division of Endocrinology and Nephrology, Leipzig University Hospital, Leipzig, Germany.
+ Dietrich, Arne. Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
+ Dietrich, Arne. Department of Visceral, Transplantation, Thoracic and Vascular Surgery, Division of Bariatric Surgery, Leipzig University Hospital, Leipzig, Germany.
+ Denecke, Timm. Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, 04103, Leipzig, Germany.
+ Busse, Harald. Department of Diagnostic and Interventional Radiology, Leipzig University Hospital, Liebigstrasse 20, 04103, Leipzig, Germany. harald.busse@medizin.uni-leipzig.de.
+MeSH Subject Headings
+ Biomarkers
+ Body Mass Index
+ Female
+ Humans
+ Image Interpretation, Computer-Assisted
+ Magnetic Resonance Imaging/mt [Methods]
+ Magnetic Resonance Imaging/st [Standards]
+ *Magnetic Resonance Imaging
+ Male
+ *Obesity/dg [Diagnostic Imaging]
+ *Obesity/pa [Pathology]
+ Organ Size
+ Sex Factors
+ *Subcutaneous Fat, Abdominal/dg [Diagnostic Imaging]
+ *Subcutaneous Fat, Abdominal/pa [Pathology]
+ Tomography, X-Ray Computed
+Abstract
+ Different types of adipose tissue can be accurately localized and quantified by tomographic imaging techniques (MRI or CT). One common shortcoming for the abdominal subcutaneous adipose tissue (ASAT) of obese subjects is the technically restricted imaging field of view (FOV). This work derives equations for the conversion between six surrogate measures and fully segmented ASAT volume and discusses the predictive power of these image-based quantities. Clinical (gender, age, anthropometry) and MRI data (1.5 T, two-point Dixon sequence) of 193 overweight and obese patients (116 female, 77 male) from a single research center for obesity were analyzed retrospectively. Six surrogate measures of fully segmented ASAT volume (VASAT) were considered: two simple ASAT lengths, two partial areas (Ap-FH, Ap-ASIS) and two partial volumes (Vp-FH, Vp-ASIS) limited by either the femoral heads (FH) or the anterior superior iliac spine (ASIS). Least-squares regression between each measure and VASAT provided slope and intercept for the computation of estimated ASAT volumes (V~ASAT). Goodness of fit was evaluated by coefficient of determination (R2) and standard deviation of percent differences (sd%) between V~ASAT and VASAT. Best agreement was observed for partial volume Vp-FH (sd% = 14.4% and R2 = 0.78), followed by Vp-ASIS (sd% = 18.1% and R2 = 0.69) and AWFASIS (sd% = 23.9% and R2 = 0.54), with minor gender differences only. Other estimates from simple lengths and partial areas were moderate only (sd% > 23.0% and R2 < 0.50). Gender differences in R2 generally ranged between 0.02 (dven) and 0.29 (Ap-FH). The common FOV restriction for MRI volumetry of ASAT in obese subjects can best be overcome by estimating VASAT from Vp-FH using the equation derived here. The very simple AWFASIS can be used with reservation.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-75985-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Michel&issn=2045-2322&title=Scientific+Reports&atitle=Abdominal+subcutaneous+fat+quantification+in+obese+patients+from+limited+field-of-view+MRI+data.&volume=10&issue=1&spage=19039&epage=&date=2020&doi=10.1038%2Fs41598-020-75985-8&pmid=33149195&sid=OVID:medline
+
+<1145>
+Unique Identifier
+ 33148837
+Title
+ THE DYNAMICS OF NEUROHUMORAL MEDIATORS OF VASOCONSTRICTION AND VASODILATION AND TROPONIN I IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION DEPENDING ON THE DEGREE OF CONCOMITANT OBESITY.
+Source
+ Wiadomosci Lekarskie. 73(9 cz. 2):1940-1943, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ryndina NG; Kravchun PG; Yermak OS; Borovyk KM; Tytova GY; Kozhyn MI
+Authors Full Name
+ Ryndina, Nataliya G; Kravchun, Pavlo G; Yermak, Olexandra S; Borovyk, Kateryna M; Tytova, Ganna Yu; Kozhyn, Mykhailo I.
+Institution
+ Ryndina, Nataliya G. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+ Kravchun, Pavlo G. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+ Yermak, Olexandra S. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+ Borovyk, Kateryna M. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+ Tytova, Ganna Yu. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+ Kozhyn, Mykhailo I. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
+MeSH Subject Headings
+ Biomarkers
+ Glycopeptides
+ Humans
+ Myocardial Infarction/co [Complications]
+ *Myocardial Infarction
+ Obesity/co [Complications]
+ Prospective Studies
+ *Troponin I
+ Vasoconstriction
+ Vasodilation
+Keyword Heading
+ MRproadrenomedulin-
+ acute myocardial infarction-
+ copeptin-
+ obesity-
+ vasoconstrictors-
+ vasodilators-
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The aim: Is to evaluate copetin's, MRproADM's and troponin's I dynamic in patients with acute myocardial infarction depending on the degree of concomitant obesity.
+
+ PATIENTS AND METHODS: Material and methods: The study included 105 patients with AMI. There were formed 2 groups: 1st group of patients with AMI and concomitant obesity (n=75), 2nd group - patients with AMI without obesity (n=30). 37 patients had obesity of the I degree, 38 patients - II degree. The groups were comparable in age and gender. Copeptin, MRproADM, troponin I were determined by enzyme immunoassay method. Data are presented as mean values and the error of the mean (M+/-m). Differences were considered statistically significant at p<0,05.
+
+ RESULTS: Results: It was found an increased copeptin's level by 73,8 % (p<0,001) in obesity I degree and by 205,9 % in obesity II degree compared with group with isolated AMI, MRproADM - by 30,68 % (p<0,001) and 54,5 % (p<0,001) respectively. Concentration of copeptin was higher by 76 % (p<0,001) in patients with AMI and II degree obesity comparing to patients with obesity of I degree, and MRproADM - by 18,3% (p<0,001) respectively. Troponin I value fully corresponded the comparison group both in obesity of I degree and II degree (p>0,05).
+
+ CONCLUSION: Conclusions: The present study provides evidence that a high activity of copeptin and MRproADM in patients with AMI and obesity of I degree with an excessive activity of a marker of vasoconstriction copeptin in conditions of moderate inadequate to the needs MRproADM functioning in patients with obesity of II degree.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycopeptides). 0 (Troponin I).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&AN=33148837
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ryndina&issn=0043-5147&title=Wiadomosci+Lekarskie&atitle=THE+DYNAMICS+OF+NEUROHUMORAL+MEDIATORS+OF+VASOCONSTRICTION+AND+VASODILATION+AND+TROPONIN+I+IN+PATIENTS+WITH+ACUTE+MYOCARDIAL+INFARCTION+DEPENDING+ON+THE+DEGREE+OF+CONCOMITANT+OBESITY.&volume=73&issue=9&spage=1940&epage=1943&date=2020&doi=&pmid=33148837&sid=OVID:medline
+
+<1146>
+Unique Identifier
+ 33148181
+Title
+ Association of hemoglobin glycation index and its interaction with obesity/family history of hypertension on hypertension risk: a community-based cross-sectional survey.
+Source
+ BMC Cardiovascular Disorders. 20(1):477, 2020 11 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mi J; Song J; Zhao Y; Wu X
+Author NameID
+ Wu, Xuesen; ORCID: https://orcid.org/0000-0001-8438-9380
+Authors Full Name
+ Mi, Jing; Song, Jian; Zhao, Yingying; Wu, Xuesen.
+Institution
+ Mi, Jing. School of Public Health, Bengbu Medical College, 2600 Donghai road, Bengbu, 233000, Anhui Province, China.
+ Song, Jian. School of Public Health, Bengbu Medical College, 2600 Donghai road, Bengbu, 233000, Anhui Province, China.
+ Zhao, Yingying. Bengbu Health Board, 568 Nanhu road, Bengbu, 233000, Anhui Province, China.
+ Wu, Xuesen. School of Public Health, Bengbu Medical College, 2600 Donghai road, Bengbu, 233000, Anhui Province, China. xuesenwu@163.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Blood Pressure
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ *Glycated Hemoglobin/an [Analysis]
+ Health Surveys
+ Humans
+ Hypertension/bl [Blood]
+ Hypertension/di [Diagnosis]
+ *Hypertension/ep [Epidemiology]
+ Male
+ Medical History Taking
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ Hemoglobin glycation index
+ Hypertension
+ Interaction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.
+
+ METHODS: The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as "measured HbA1c-predicted HbA1c" and divided into four categories according to quartile. The following indicators were used to assess interactive effects: (1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.
+
+ RESULTS: Specifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (p < 0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87 (95% CI 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI: 1.36, 95% CI 0.11-2.63; AP: 0.43, 95% CI 0.17-0.69; and SI:2.68, 95% CI 1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95% CI 0.24-1.85), AP (0.33, 95% CI 0.11-0.56) and SI (1.96, 95% CI 1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95% CI 0.01-0.54) was observed to be significant.
+
+ CONCLUSION: High HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12872-020-01762-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mi&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Association+of+hemoglobin+glycation+index+and+its+interaction+with+obesity%2Ffamily+history+of+hypertension+on+hypertension+risk%3A+a+community-based+cross-sectional+survey.&volume=20&issue=1&spage=477&epage=&date=2020&doi=10.1186%2Fs12872-020-01762-0&pmid=33148181&sid=OVID:medline
+
+<1147>
+Unique Identifier
+ 33143700
+Title
+ Depression and cardiovascular risk-association among Beck Depression Inventory, PCSK9 levels and insulin resistance.
+Source
+ Cardiovascular Diabetology. 19(1):187, 2020 11 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Macchi C; Favero C; Ceresa A; Vigna L; Conti DM; Pesatori AC; Racagni G; Corsini A; Ferri N; Sirtori CR; Buoli M; Bollati V; Ruscica M
+Author NameID
+ Ruscica, M; ORCID: https://orcid.org/0000-0002-0195-7061
+Authors Full Name
+ Macchi, C; Favero, C; Ceresa, A; Vigna, L; Conti, D M; Pesatori, A C; Racagni, G; Corsini, A; Ferri, N; Sirtori, C R; Buoli, M; Bollati, V; Ruscica, M.
+Institution
+ Macchi, C. Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy.
+ Favero, C. EPIGET Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy.
+ Ceresa, A. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
+ Vigna, L. Occupational Medicine Unit, Fondazione Ca Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
+ Conti, D M. Occupational Medicine Unit, Fondazione Ca Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
+ Pesatori, A C. EPIGET Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy.
+ Racagni, G. Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy.
+ Corsini, A. Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy.
+ Corsini, A. IRCCS, Multimedica, Sesto San Giovanni (Milan), Italy.
+ Ferri, N. Dipartimento di Scienze del Farmaco, Universita degli Studi di Padova, Padua, Italy.
+ Sirtori, C R. Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy.
+ Buoli, M. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
+ Buoli, M. Department of Neurosciences and Mental Health, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy.
+ Bollati, V. EPIGET Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy. valentina.bollati@unimi.it.
+ Ruscica, M. Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy. massimiliano.ruscica@unimi.it.
+MeSH Subject Headings
+ Adult
+ *Affect
+ Biomarkers
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/et [Etiology]
+ Cross-Sectional Studies
+ Depression/bl [Blood]
+ Depression/di [Diagnosis]
+ *Depression/et [Etiology]
+ Depression/px [Psychology]
+ Female
+ Heart Disease Risk Factors
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Proprotein Convertase 9/bl [Blood]
+ Retrospective Studies
+ Risk Assessment
+Keyword Heading
+ Beck Depression Inventory
+ Cardiovascular risk
+ Depression
+ Framingham risk score
+ Obesity
+ Proprotein Converatse Subtilisin/Kexin type 9
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Depression and cardiovascular disease (CVD) are among the most common causes of disability in high-income countries, depression being associated with a 30% increased risk of future CV events. Depression is twice as common in people with diabetes and is associated with a 60% rise in the incidence of type 2 diabetes, an independent CVD risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of low-density lipoprotein cholesterol, has been related to a large number of CV risk factors, including insulin resistance. Aim of this study was to investigate whether the presence of depression could affect PCSK9 levels in a population of obese subjects susceptible to depressive symptoms and how these changes may mediate a pre-diabetic risk.
+
+ RESULTS: In 389 obese individuals, the Beck Depression Inventory (BDI-II) was significantly associated with PCSK9 levels. For every one-unit increment in BDI-II score, PCSK9 rose by 1.85 ng/mL. Depression was associated also with the HOMA-IR (homeostatic model assessment index of insulin resistance), 11% of this effect operating indirectly via PCSK9.
+
+ CONCLUSIONS: This study indicates a possible mechanism linking depression and insulin resistance, a well-known CV risk factor, providing evidence for a significant role of PCSK9.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4-21 (PCSK9 protein, human). EC 3-4-21 (Proprotein Convertase 9).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12933-020-01158-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Macchi&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Depression+and+cardiovascular+risk-association+among+Beck+Depression+Inventory%2C+PCSK9+levels+and+insulin+resistance.&volume=19&issue=1&spage=187&epage=&date=2020&doi=10.1186%2Fs12933-020-01158-6&pmid=33143700&sid=OVID:medline
+
+<1148>
+Unique Identifier
+ 33143306
+Title
+ Improved Nutritional Knowledge in the Obese Adult Population Modifies Eating Habits and Serum and Anthropometric Markers.
+Source
+ Nutrients. 12(11), 2020 Oct 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lopez-Hernandez L; Martinez-Arnau FM; Perez-Ros P; Drehmer E; Pablos A
+Author NameID
+ Lopez-Hernandez, Lourdes; ORCID: https://orcid.org/0000-0002-8827-5484
+ Martinez-Arnau, Francisco Miguel; ORCID: https://orcid.org/0000-0003-1949-3290
+ Perez-Ros, Pilar; ORCID: https://orcid.org/0000-0002-2118-9792
+ Pablos, Ana; ORCID: https://orcid.org/0000-0002-1915-9906
+Authors Full Name
+ Lopez-Hernandez, Lourdes; Martinez-Arnau, Francisco Miguel; Perez-Ros, Pilar; Drehmer, Eraci; Pablos, Ana.
+Institution
+ Lopez-Hernandez, Lourdes. Department of Nursing, Universidad Catolica de Valencia San Vicente Martir, 46007 Valencia, Spain.
+ Lopez-Hernandez, Lourdes. Hospital Universitario y Politecnico La Fe, 46026 Valencia, Spain.
+ Martinez-Arnau, Francisco Miguel. Department of Nursing, Universidad Catolica de Valencia San Vicente Martir, 46007 Valencia, Spain.
+ Martinez-Arnau, Francisco Miguel. Department of Physiotherapy, Universitat de Valencia, 46010 Valencia, Spain.
+ Martinez-Arnau, Francisco Miguel. Frailty and Cognitive Impairment Research Group (FROG), Universitat de Valencia, 46010 Valencia, Spain.
+ Perez-Ros, Pilar. Department of Nursing, Universidad Catolica de Valencia San Vicente Martir, 46007 Valencia, Spain.
+ Perez-Ros, Pilar. Frailty and Cognitive Impairment Research Group (FROG), Universitat de Valencia, 46010 Valencia, Spain.
+ Perez-Ros, Pilar. Department of Nursing, Faculty of Nursing and Podiatry, Universitat de Valencia, 46010 Valencia, Spain.
+ Drehmer, Eraci. Department of Basic Sciences, Universidad Catolica de Valencia San Vicente Martir, 46007 Valencia, Spain.
+ Pablos, Ana. Department of Physical Activity and Sport Sciences, Universidad Catolica de Valencia San Vicente Martir, 46007 Valencia, Spain.
+MeSH Subject Headings
+ Adult
+ Anthropometry
+ *Biomarkers/bl [Blood]
+ Feeding Behavior
+ Female
+ Food
+ *Health Knowledge, Attitudes, Practice
+ Humans
+ Linear Models
+ Male
+ Middle Aged
+ *Nutritional Physiological Phenomena
+ *Obesity/ep [Epidemiology]
+Keyword Heading
+ attitudes
+ diet
+ energy expenditure
+ health knowledge
+ macronutrients
+ micronutrients
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Multicomponent lifestyle interventions achieve good results in the management of obesity among the adult population. However, their implementation in certain populations poses difficulties. A good level of nutritional knowledge enables people to make changes in their diet that improve their health. This study aims to assess the relationship between nutritional knowledge and nutritional parameters such as dietary intake, anthropometric parameters and biomarkers. A before-after, non-randomized interventional study involving a two-monthly nutritional educational intervention was carried out over 8 months. Anthropometric and biomarker data were collected, and nutritional knowledge was evaluated using the Bach questionnaire and food frequency questionnaire (FFQ). The study comprised 66 overweight and obese adults with mean age of 50.23 years. Females predominated (84.8%). At the end of the intervention, nutritional knowledge increased significantly, with a significant reduction in the consumption of sweets, soft drinks, high-fat products, and processed meats, and an increase in the intake of lean meat and poultry. A 3% decrease in body weight was observed. An intervention for the management of obesity in the adult population based on nutritional education achieves weight loss, modifications in eating habits and reduction of fat intake. Increased nutritional knowledge is associated with healthier eating habits and a decreased cardiovascular risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12113355
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lopez-Hernandez&issn=2072-6643&title=Nutrients&atitle=Improved+Nutritional+Knowledge+in+the+Obese+Adult+Population+Modifies+Eating+Habits+and+Serum+and+Anthropometric+Markers.&volume=12&issue=11&spage=&epage=&date=2020&doi=10.3390%2Fnu12113355&pmid=33143306&sid=OVID:medline
+
+<1149>
+Unique Identifier
+ 33141863
+Title
+ Urbanization and health: The effects of the built environment on chronic disease risk factors among women in Tanzania.
+Source
+ PLoS ONE [Electronic Resource]. 15(11):e0241810, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pinchoff J; Mills CW; Balk D
+Author NameID
+ Pinchoff, Jessie; ORCID: https://orcid.org/0000-0003-3155-595X
+Authors Full Name
+ Pinchoff, Jessie; Mills, Carrie W; Balk, Deborah.
+Institution
+ Pinchoff, Jessie. Department of Poverty Gender and Youth, Population Council, New York, NY, United States of America.
+ Mills, Carrie W. CUNY Institute for Demographic Research, City University of New York, New York, NY, United States of America.
+ Balk, Deborah. CUNY Institute for Demographic Research, City University of New York, New York, NY, United States of America.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ Cardiovascular Diseases
+ *Chronic Disease/ep [Epidemiology]
+ Cross-Sectional Studies
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Overweight
+ Risk Factors
+ Rural Population
+ Tanzania/ep [Epidemiology]
+ *Urban Health
+ *Urban Population
+ Young Adult
+Abstract
+ Sub-Saharan Africa is experiencing rapid urban growth. Cities enable greater access to health services and improved water and sanitation infrastructure, leading to some improvements in health. However, urban settings may also be associated with more sedentary, stressful lifestyles and consumption of less nutritious food. C-reactive protein (CRP) is a measure of chronic inflammation predictive of cardiovascular disease, and high body mass index (BMI), a ratio of weight to height, indicates overweight or obesity and is associated with an increased risk of many chronic diseases. To explore the association between urbanicity and these two markers, we overlaid data from the 2010 Tanzania Demographic and Health Survey (DHS) with a satellite-derived measure of built environment. Linear regression models were constructed for the outcomes of BMI and CRP, by 1) administratively defined urban/rural categorization from the DHS, 2) satellite derived built environment, and 3) built environment stratified by urban/rural. A total of 2,212 women were included; 23% had elevated CRP, 21% were overweight or obese. A third (33%) lived in a highly built up area and 29% lived in an area classified as urban. A strong positive association between both CRP and BMI and built environment was detected; log CRP increased 0.43 in the highest built up areas compared to not built up (p<0.05); log BMI increased 0.02 in the most built up areas compared to not built up (p<0.05). However, comparing urban to rural category was only significant in unadjusted models. Models stratified by urban/rural category highlight that the variation in CRP and BMI by built environment is mainly driven by rural areas; within urban areas there is less variation. Our findings highlight the potential negative effects of urbanicity on chronic disease markers, with potentially more change detected for those transitioning from rural to urban lifestyles. Satellite-derived urbanicity measures are reproducible and provide more nuanced understanding of effects of built environment on health.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0241810
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pinchoff&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Urbanization+and+health%3A+The+effects+of+the+built+environment+on+chronic+disease+risk+factors+among+women+in+Tanzania.&volume=15&issue=11&spage=e0241810&epage=&date=2020&doi=10.1371%2Fjournal.pone.0241810&pmid=33141863&sid=OVID:medline
+
+<1150>
+Unique Identifier
+ 33139537
+Title
+ Antibody-mediated activation of the FGFR1/Klothobeta complex corrects metabolic dysfunction and alters food preference in obese humans.
+Source
+ Proceedings of the National Academy of Sciences of the United States of America. 117(46):28992-29000, 2020 11 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baruch A; Wong C; Chinn LW; Vaze A; Sonoda J; Gelzleichter T; Chen S; Lewin-Koh N; Morrow L; Dheerendra S; Boismenu R; Gutierrez J; Wakshull E; Wilson ME; Arora PS
+Author NameID
+ Baruch, Amos; ORCID: https://orcid.org/0000-0003-3831-3806
+ Wong, Chin; ORCID: https://orcid.org/0000-0002-4404-9231
+ Chinn, Leslie W; ORCID: https://orcid.org/0000-0003-3127-6758
+ Vaze, Anjali; ORCID: https://orcid.org/0000-0003-4392-3246
+ Morrow, Linda; ORCID: https://orcid.org/0000-0003-3252-4477
+ Boismenu, Richard; ORCID: https://orcid.org/0000-0002-0570-3720
+ Wilson, Maria E; ORCID: https://orcid.org/0000-0002-9104-5444
+ Arora, Puneet S; ORCID: https://orcid.org/0000-0001-6450-1224
+Authors Full Name
+ Baruch, Amos; Wong, Chin; Chinn, Leslie W; Vaze, Anjali; Sonoda, Junichiro; Gelzleichter, Thomas; Chen, Shan; Lewin-Koh, Nicholas; Morrow, Linda; Dheerendra, Suresh; Boismenu, Richard; Gutierrez, Johnny; Wakshull, Eric; Wilson, Maria E; Arora, Puneet S.
+Institution
+ Baruch, Amos. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Wong, Chin. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Chinn, Leslie W. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Vaze, Anjali. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Sonoda, Junichiro. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Gelzleichter, Thomas. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Chen, Shan. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Lewin-Koh, Nicholas. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Morrow, Linda. ProSciento, Inc., Chula Vista, CA 91911.
+ Dheerendra, Suresh. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Boismenu, Richard. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Gutierrez, Johnny. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Wakshull, Eric. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Wilson, Maria E. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
+ Arora, Puneet S. Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080; puneetarora.md@gmail.com.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adipose Tissue/me [Metabolism]
+ Adolescent
+ Adult
+ Aged
+ Animals
+ Antibodies/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ Body Weight
+ Female
+ Fibroblast Growth Factors
+ *Food Preferences
+ Homeostasis
+ Humans
+ Macaca fascicularis
+ Male
+ Mice
+ Middle Aged
+ *Obesity/dt [Drug Therapy]
+ *Obesity/me [Metabolism]
+ *Receptor, Fibroblast Growth Factor, Type 1/im [Immunology]
+ *Receptor, Fibroblast Growth Factor, Type 1/me [Metabolism]
+ Weight Loss
+ Young Adult
+Keyword Heading
+ FGF21 receptor activation
+ food preference
+ metabolism
+ obesity
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and eating/drinking behavior via FGF receptor 1/Klothobeta (FGFR1/KLB) complexes expressed in adipocytes, pancreatic acinar cells, and the nervous system in mice. Chronic administration of recombinant FGF21 or engineered variants improves metabolic health in rodents, nonhuman primates, and humans; however, the rapid turnover of these molecules limits therapeutic utility. Here we show that the bispecific anti-FGFR1/KLB agonist antibody BFKB8488A induced marked weight loss in obese cynomolgus monkeys while elevating serum adiponectin and the adipose expression of FGFR1 target genes, demonstrating its action as an FGF21 mimetic. In a randomized, placebo-controlled, single ascending-dose study in overweight/obese human participants, subcutaneous BFKB8488A injection caused transient body weight reduction, sustained improvement in cardiometabolic parameters, and a trend toward reduction in preference for sweet taste and carbohydrate intake. These data suggest that specific activation of the FGFR1/KLB complex in humans can be used as therapy for obesity-related metabolic defects. Copyright © 2020 the Author(s). Published by PNAS.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Antibodies). 0 (Biomarkers). 0 (FGF21 protein, human). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors). EC 2-7-10-1 (FGFR1 protein, human). EC 2-7-10-1 (Receptor, Fibroblast Growth Factor, Type 1).
+Publication Type
+ Clinical Trial. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1073%2fpnas.2012073117
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baruch&issn=0027-8424&title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&atitle=Antibody-mediated+activation+of+the+FGFR1%2FKlothobeta+complex+corrects+metabolic+dysfunction+and+alters+food+preference+in+obese+humans.&volume=117&issue=46&spage=28992&epage=29000&date=2020&doi=10.1073%2Fpnas.2012073117&pmid=33139537&sid=OVID:medline
+
+<1151>
+Unique Identifier
+ 33129264
+Title
+ Gut microbiome profiling of a rural and urban South African cohort reveals biomarkers of a population in lifestyle transition.
+Source
+ BMC Microbiology. 20(1):330, 2020 10 31.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Oduaran OH; Tamburini FB; Sahibdeen V; Brewster R; Gomez-Olive FX; Kahn K; Norris SA; Tollman SM; Twine R; Wade AN; Wagner RG; Lombard Z; Bhatt AS; Hazelhurst S
+Author NameID
+ Oduaran, O H; ORCID: https://orcid.org/0000-0002-3033-7873
+Authors Full Name
+ Oduaran, O H; Tamburini, F B; Sahibdeen, V; Brewster, R; Gomez-Olive, F X; Kahn, K; Norris, S A; Tollman, S M; Twine, R; Wade, A N; Wagner, R G; Lombard, Z; Bhatt, A S; Hazelhurst, S.
+Institution
+ Oduaran, O H. Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa. ovokeraye.oduaran@wits.ac.za.
+ Oduaran, O H. Division of Human Genetics, National Health Laboratory Service, and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. ovokeraye.oduaran@wits.ac.za.
+ Tamburini, F B. Department of Genetics, Stanford University, Stanford, CA, USA.
+ Sahibdeen, V. Division of Human Genetics, National Health Laboratory Service, and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Brewster, R. School of Medicine, Stanford University, Stanford, CA, USA.
+ Gomez-Olive, F X. MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Gomez-Olive, F X. INDEPTH Network, East Legon, Accra, Ghana.
+ Kahn, K. MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Kahn, K. INDEPTH Network, East Legon, Accra, Ghana.
+ Norris, S A. SAMRC Developmental Pathways for Health Research Unit, Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.
+ Norris, S A. School of Human Development and Health, University of Southampton, Southampton, UK.
+ Tollman, S M. MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Tollman, S M. INDEPTH Network, East Legon, Accra, Ghana.
+ Twine, R. MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Wade, A N. MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Wagner, R G. MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Wagner, R G. INDEPTH Network, East Legon, Accra, Ghana.
+ Lombard, Z. Division of Human Genetics, National Health Laboratory Service, and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Bhatt, A S. Department of Genetics, Stanford University, Stanford, CA, USA.
+ Bhatt, A S. School of Medicine, Stanford University, Stanford, CA, USA.
+ Bhatt, A S. Department of Medicine (Hematology), Stanford University, Stanford, CA, USA.
+ Hazelhurst, S. Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa. scott.hazelhurst@wits.ac.za.
+ Hazelhurst, S. School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa. scott.hazelhurst@wits.ac.za.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Aged
+ Bacteria/ge [Genetics]
+ Biomarkers
+ Cohort Studies
+ Diet
+ Feces/mi [Microbiology]
+ Female
+ *Gastrointestinal Microbiome/ge [Genetics]
+ Humans
+ *Life Style/eh [Ethnology]
+ *Microbiota/ge [Genetics]
+ Middle Aged
+ Obesity/mi [Microbiology]
+ Pilot Projects
+ RNA, Ribosomal, 16S/ge [Genetics]
+ Rural Population
+ South Africa/eh [Ethnology]
+Keyword Heading
+ 16S
+ African microbiome
+ Epidemiological transition
+ Obesity
+ South African microbiome
+ Transitional microbiome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Comparisons of traditional hunter-gatherers and pre-agricultural communities in Africa with urban and suburban Western North American and European cohorts have clearly shown that diet, lifestyle and environment are associated with gut microbiome composition. Yet, little is known about the gut microbiome composition of most communities in the very diverse African continent. South Africa comprises a richly diverse ethnolinguistic population that is experiencing an ongoing epidemiological transition and concurrent spike in the prevalence of obesity, largely attributed to a shift towards more Westernized diets and increasingly inactive lifestyle practices. To characterize the microbiome of African adults living in more mainstream lifestyle settings and investigate associations between the microbiome and obesity, we conducted a pilot study, designed collaboratively with community leaders, in two South African cohorts representative of urban and transitioning rural populations. As the rate of overweight and obesity is particularly high in women, we collected single time-point stool samples from 170 HIV-negative women (51 at Soweto; 119 at Bushbuckridge), performed 16S rRNA gene sequencing on these samples and compared the data to concurrently collected anthropometric data.
+
+ RESULTS: We found the overall gut microbiome of our cohorts to be reflective of their ongoing epidemiological transition. Specifically, we find that geographical location was more important for sample clustering than lean/obese status and observed a relatively higher abundance of the Melainabacteria, Vampirovibrio, a predatory bacterium, in Bushbuckridge. Also, Prevotella, despite its generally high prevalence in the cohorts, showed an association with obesity. In comparisons with benchmarked datasets representative of non-Western populations, relatively higher abundance values were observed in our dataset for Barnesiella (log2fold change (FC) = 4.5), Alistipes (log2FC = 3.9), Bacteroides (log2FC = 4.2), Parabacteroides (log2FC = 3.1) and Treponema (log2FC = 1.6), with the exception of Prevotella (log2FC = - 4.7).
+
+ CONCLUSIONS: Altogether, this work identifies putative microbial features associated with host health in a historically understudied community undergoing an epidemiological transition. Furthermore, we note the crucial role of community engagement to the success of a study in an African setting, the importance of more population-specific studies to inform targeted interventions as well as present a basic foundation for future research.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Ribosomal, 16S).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12866-020-02017-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Oduaran&issn=1471-2180&title=BMC+Microbiology&atitle=Gut+microbiome+profiling+of+a+rural+and+urban+South+African+cohort+reveals+biomarkers+of+a+population+in+lifestyle+transition.&volume=20&issue=1&spage=330&epage=&date=2020&doi=10.1186%2Fs12866-020-02017-w&pmid=33129264&sid=OVID:medline
+
+<1152>
+Unique Identifier
+ 33126555
+Title
+ Impact of Physical Activity and Weight Loss on Fat Mass, Glucose Metabolism, and Inflammation in Older African Americans with Osteoarthritis.
+Source
+ Nutrients. 12(11), 2020 Oct 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ McLeod A; Schiffer L; Castellanos K; DeMott A; Olender S; Fitzgibbon M; Hughes S; Fantuzzi G; Tussing-Humphreys L
+Authors Full Name
+ McLeod, Andrew; Schiffer, Linda; Castellanos, Karla; DeMott, Andrew; Olender, Sarah; Fitzgibbon, Marian; Hughes, Susan; Fantuzzi, Giamila; Tussing-Humphreys, Lisa.
+Institution
+ McLeod, Andrew. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
+ McLeod, Andrew. Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60608, USA.
+ Schiffer, Linda. Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60608, USA.
+ Castellanos, Karla. Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
+ DeMott, Andrew. Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60608, USA.
+ DeMott, Andrew. Center for Research on Health and Aging, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60608, USA.
+ Olender, Sarah. Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
+ Fitzgibbon, Marian. Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60608, USA.
+ Fitzgibbon, Marian. Department of Pediatrics, University of Illinois at Chicago, Chicago, IL 60612, USA.
+ Fitzgibbon, Marian. University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.
+ Hughes, Susan. Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60608, USA.
+ Hughes, Susan. Center for Research on Health and Aging, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60608, USA.
+ Hughes, Susan. Department of Community Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA.
+ Fantuzzi, Giamila. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
+ Tussing-Humphreys, Lisa. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
+ Tussing-Humphreys, Lisa. Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60608, USA.
+ Tussing-Humphreys, Lisa. University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.
+MeSH Subject Headings
+ Black or African American
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Composition
+ Body Mass Index
+ Chronic Disease/pc [Prevention & Control]
+ Diet, Reducing/mt [Methods]
+ *Exercise/ph [Physiology]
+ Exercise Therapy/mt [Methods]
+ Fasting/bl [Blood]
+ Female
+ Humans
+ Inflammation
+ Inflammation Mediators/bl [Blood]
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Intra-Abdominal Fat/pp [Physiopathology]
+ Life Style
+ Male
+ Neoplasms/et [Etiology]
+ Neoplasms/pc [Prevention & Control]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Osteoarthritis/bl [Blood]
+ Osteoarthritis/co [Complications]
+ *Osteoarthritis/th [Therapy]
+ Overweight/bl [Blood]
+ Overweight/co [Complications]
+ *Overweight/th [Therapy]
+ Risk Factors
+ Treatment Outcome
+ *Weight Loss/ph [Physiology]
+ *Weight Reduction Programs/mt [Methods]
+Keyword Heading
+ African American
+ adiposity
+ cancer prevention
+ dietary intervention
+ insulin resistance
+ physical activity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ (1) Background: There are currently very few interventions performed within a community setting that compare the effects of physical activity (PA) versus PA plus weight loss on cancer and chronic disease risk in older African Americans. Therefore, we investigated the impact of an 8 week (24 session) PA intervention compared to a PA plus weight loss intervention on fat mass, glucose metabolism, and markers of inflammation in older, overweight and obese African Americans. (2) Methods: Subjects were randomized to a PA (n = 83) or PA plus weight loss (n = 72) intervention that met three times weekly for 8 weeks. At baseline and post-intervention, anthropometrics, body composition, systemic inflammation (high-sensitivity C-reactive protein, tumor necrosis factor-alpha, and interleukin 6), fasting glucose, insulin and homeostasis model assessment-insulin resistance (HOMA-IR) were determined. (3) Results: Subjects had a mean age of 67 years (SD = 5.3) and were mostly women (88%). The PA plus weight loss group lost more total and visceral fat than the PA group (-4.0% vs. +0.6% and -4.1% vs. +3.7%, respectively, p < 0.01 for both). Changes in inflammation and glucose metabolism were similar between groups post-intervention. Within the PA plus weight loss group only, serum insulin and HOMA-IR decreased significantly. (4) Conclusions: PA combined with weight loss can decrease total and visceral fat mass and improve insulin sensitivity, confirming that these cancer- and chronic disease-related risk factors are influenced by relatively modest lifestyle changes in the short term.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Inflammation Mediators). 0 (Insulin).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12113299
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=McLeod&issn=2072-6643&title=Nutrients&atitle=Impact+of+Physical+Activity+and+Weight+Loss+on+Fat+Mass%2C+Glucose+Metabolism%2C+and+Inflammation+in+Older+African+Americans+with+Osteoarthritis.&volume=12&issue=11&spage=&epage=&date=2020&doi=10.3390%2Fnu12113299&pmid=33126555&sid=OVID:medline
+
+<1153>
+Unique Identifier
+ 33112256
+Title
+ In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone.
+Source
+ European Journal of Endocrinology. 183(6):669-676, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van der Valk ES; van der Voorn B; Iyer AM; van den Berg SAA; Savas M; de Rijke YB; van den Akker ELT; Melander O; van Rossum EFC
+Authors Full Name
+ van der Valk, Eline S; van der Voorn, Bibian; Iyer, Anand M; van den Berg, Sjoerd A A; Savas, Mesut; de Rijke, Yolanda B; van den Akker, Erica L T; Melander, Olle; van Rossum, Elisabeth F C.
+Institution
+ van der Valk, Eline S. Obesity Centre CGG, Department of Internal Medicine.
+ van der Valk, Eline S. Division of Endocrinology, Department of Internal Medicine.
+ van der Voorn, Bibian. Obesity Centre CGG, Department of Internal Medicine.
+ van der Voorn, Bibian. Division of Endocrinology, Department of Internal Medicine.
+ van der Voorn, Bibian. Division of Pediatric Endocrinology, Department of Pediatrics.
+ Iyer, Anand M. Obesity Centre CGG, Department of Internal Medicine.
+ Iyer, Anand M. Division of Endocrinology, Department of Internal Medicine.
+ van den Berg, Sjoerd A A. Division of Endocrinology, Department of Internal Medicine.
+ van den Berg, Sjoerd A A. Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
+ Savas, Mesut. Obesity Centre CGG, Department of Internal Medicine.
+ Savas, Mesut. Division of Endocrinology, Department of Internal Medicine.
+ de Rijke, Yolanda B. Obesity Centre CGG, Department of Internal Medicine.
+ de Rijke, Yolanda B. Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
+ van den Akker, Erica L T. Obesity Centre CGG, Department of Internal Medicine.
+ van den Akker, Erica L T. Division of Pediatric Endocrinology, Department of Pediatrics.
+ Melander, Olle. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Melander, Olle. Department of Internal Medicine, Skane University Hospital, Malmo, Sweden.
+ van Rossum, Elisabeth F C. Obesity Centre CGG, Department of Internal Medicine.
+ van Rossum, Elisabeth F C. Division of Endocrinology, Department of Internal Medicine.
+MeSH Subject Headings
+ Adult
+ Arginine Vasopressin/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Corticotropin-Releasing Hormone/me [Metabolism]
+ *Cortisone/me [Metabolism]
+ Cross-Sectional Studies
+ *Cushing Syndrome/et [Etiology]
+ Female
+ Glucocorticoids/me [Metabolism]
+ *Glycopeptides/me [Metabolism]
+ Hair/ch [Chemistry]
+ Humans
+ *Hydrocortisone/me [Metabolism]
+ Hypothalamo-Hypophyseal System/me [Metabolism]
+ Male
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Pituitary-Adrenal System/me [Metabolism]
+Abstract
+ CONTEXT: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the hypothalamic-pituitary adrenal axis (HPA axis), we hypothesize that AVP contributes to chronic hypercortisolism in obesity.
+
+ OBJECTIVE: To investigate whether copeptin levels are associated with Higher HairF and HairE levels in obesity.
+
+ DESIGN: A cross-sectional study in 51 adults with obesity (BMI >=30 kg/m2).
+
+ METHODS: Associations and interactions between copeptin, HairF, HairE, and cardiometabolic parameters were cross-sectionally analyzed.
+
+ RESULTS: Copeptin was strongly associated with BMI and waist circumference (WC) (rho = 0.364 and 0.530, P = 0.008 and <0.001, respectively), also after correction for confounders. There were no associations between copeptin and HairF or HairE on a continuous or dichotomized scale, despite correction for confounders.
+
+ CONCLUSION: In patients with obesity, AVP seems not a major contributor to the frequently observed high cortisol levels. Other factors which stimulate the HPA axis or affect cortisol synthesis or breakdown may be more important than the influence of AVP on long-term glucocorticoid levels in obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glucocorticoids). 0 (Glycopeptides). 0 (copeptins). 113-79-1 (Arginine Vasopressin). 9015-71-8 (Corticotropin-Releasing Hormone). V27W9254FZ (Cortisone). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1530%2fEJE-20-0077
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+der+Valk&issn=0804-4643&title=European+Journal+of+Endocrinology&atitle=In+adults+with+obesity%2C+copeptin+is+linked+with+BMI+but+is+not+associated+with+long-term+exposure+to+cortisol+and+cortisone.&volume=183&issue=6&spage=669&epage=676&date=2020&doi=10.1530%2FEJE-20-0077&pmid=33112256&sid=OVID:medline
+
+<1154>
+Unique Identifier
+ 33109143
+Title
+ Association between a novel dietary lipophilic index (LI) with metabolic phenotypes in a community-based study in Tabriz- Iran.
+Source
+ BMC Endocrine Disorders. 20(1):159, 2020 Oct 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Soltani N; Farhangi MA; Nikniaz L; Mahmoudinezhad M
+Authors Full Name
+ Soltani, Nika; Farhangi, Mahdieh Abbasalizad; Nikniaz, Leila; Mahmoudinezhad, Mahsa.
+Institution
+ Soltani, Nika. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Farhangi, Mahdieh Abbasalizad. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. abbasalizad_m@yahoo.com.
+ Nikniaz, Leila. Tabriz Health Services Management Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Mahmoudinezhad, Mahsa. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Community-Based Participatory Research
+ Cross-Sectional Studies
+ *Dietary Fats/ae [Adverse Effects]
+ Dyslipidemias/et [Etiology]
+ Dyslipidemias/me [Metabolism]
+ *Dyslipidemias/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Iran
+ *Lipids/ae [Adverse Effects]
+ Male
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome/pa [Pathology]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ Dyslipidemia
+ Lipophilic index
+ Metabolic parameters
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Dietary fatty acids are important dietary determinants of metabolic disorders in human. However, it is important to develop an index that considers not only the amount of dietary fatty acids but also the structure, fluidity and melting point of them. In the current study we investigated the association between a novel dietary lipophilic index (LI) with metabolic profile and dyslipidemia in a community based study in Tabriz-Iran.
+
+ METHODS: Dietary data were collected using a validated, 79-food item, semi-quantitative food frequency questionnaire, and dietary LI was calculated. Anthropometric variables were measured and metabolic profile including blood sugar, serum lipids and liver enzymes were assessed. Metabolic syndrome was defined according to the adult treatment panel (ATP) III criteria.
+
+ RESULTS: The mean age of the participants was 42.53 +/- 12.03 years and most of the participants were women. Mean of dietary LI was 34.99 +/- 6.91. Higher dietary LI was associated with higher body mass index (BMI) (beta = 0.17, P < 0.04), waist circumference (beta = 0.18, P < 0.01) and systolic blood pressure (beta = 0.27, P < 0.01). Also LI was increased with increasing waist circumference (0.001), low density lipoprotein cholesterol (LDL-C) (0.001), and negatively associated with high density lipoprotein cholesterol (HDL-C) (0.001).
+
+ CONCLUSION: The novel dietary LI was considered as a useful tool in prediction of cardio-metabolic risk factors including general and central obesity, dyslipidemia and metabolic syndrome in a population-based study in Iran. Further researches in other disease and populations could highlight the application of this index in clinical settings.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fats). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12902-020-00638-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Soltani&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Association+between+a+novel+dietary+lipophilic+index+%28LI%29+with+metabolic+phenotypes+in+a+community-based+study+in+Tabriz-+Iran.&volume=20&issue=1&spage=159&epage=&date=2020&doi=10.1186%2Fs12902-020-00638-w&pmid=33109143&sid=OVID:medline
+
+<1155>
+Unique Identifier
+ 33099522
+Title
+ FAT TISSUE AND SYNTHESIZED BY HER ADIPOKINES AS MARKERS INDICATING THE DEVELOPMENT AND PROGRESS OF OSTEOARTHRITIS.
+Source
+ Wiadomosci Lekarskie. 73(9 cz. 1):1818-1823, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jarecki J; Tomczyk-Warunek A; Wicha M; Horecka A; Blicharski R; Dobrzynski M
+Authors Full Name
+ Jarecki, Jaromir; Tomczyk-Warunek, Agnieszka; Wicha, Mateusz; Horecka, Anna; Blicharski, Rudolf; Dobrzynski, Maciej.
+Institution
+ Jarecki, Jaromir. CHAIR AND DEPARTMENT OF REHABILITATION AND ORTHOPAEDICS, MEDICAL UNIVERSITY OF LUBLIN, LUBLIN, POLAND.
+ Tomczyk-Warunek, Agnieszka. CHAIR AND DEPARTMENT OF REHABILITATION AND ORTHOPAEDICS, MEDICAL UNIVERSITY OF LUBLIN, LUBLIN, POLAND.
+ Wicha, Mateusz. CHAIR AND DEPARTMENT OF REHABILITATION AND ORTHOPAEDICS, MEDICAL UNIVERSITY OF LUBLIN, LUBLIN, POLAND.
+ Horecka, Anna. CHAIR AND DEPARTMENT OF MEDICAL CHEMISTRY, MEDICAL UNIVERSITY OF LUBLIN, LUBLIN, POLAND.
+ Blicharski, Rudolf. CHAIR AND DEPARTMENT OF REHABILITATION AND ORTHOPAEDICS, MEDICAL UNIVERSITY OF LUBLIN, LUBLIN, POLAND.
+ Dobrzynski, Maciej. DEPARTMENT OF CONSERVATIVE DENTISTRY AND PEDODONTICS, WROCLAW, POLAND.
+MeSH Subject Headings
+ *Adipokines
+ Adipose Tissue
+ Biomarkers
+ Humans
+ Obesity/co [Complications]
+ *Osteoarthritis
+Keyword Heading
+ biomarkers-
+ adipokines-
+ obesity-
+ osteoarthritis-
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Arthrosis as osteoarthritis is a global problem that affects more and more people and is associated with severe chronic pain, reduced mobility and, consequently, disability. The etiology of degenerative disease is complex and depends on many factors. However, its course was not fully understood. One of the factors affecting the development of arthrosis is obesity. Obesity is a growing problem. Over the past 30 years, the number of overweight people has almost doubled. In people suffering from obesity, whose body mass index is above 30kg/m2, the risk of developing degenerative changes in articular cartilage is six times higher than the risk of developing this disease in people with normal body weight. Osteoarthritis is detected when the symptoms get worse where the changes are already at some stage. Therefore, a lot of research is currently underway to find suitable biomarkers, which would indicate the potential development of degenerative changes in the future and at the same time the possibility of inhibiting their activity. One of them may be adipokines, which are synthesized by adipose tissue and affect cartilage. In obese people, adipokines may contribute to the inflammation of the low charterer, whichaccompanies both obesity and arthrosis. These compounds can be specific biomarkers to assess the degree of progression and severity of osteoarthritis. The aim: To assess the importance of obesity and adipokines produced by adipose tissue as specific markers of arthrosis.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&AN=33099522
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jarecki&issn=0043-5147&title=Wiadomosci+Lekarskie&atitle=FAT+TISSUE+AND+SYNTHESIZED+BY+HER+ADIPOKINES+AS+MARKERS+INDICATING+THE+DEVELOPMENT+AND+PROGRESS+OF+OSTEOARTHRITIS.&volume=73&issue=9&spage=1818&epage=1823&date=2020&doi=&pmid=33099522&sid=OVID:medline
+
+<1156>
+Unique Identifier
+ 33097705
+Title
+ Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content.
+Source
+ Nature communications . 11(1):5355, 2020 10 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhao Y; Pilvar A; Tank A; Peterson H; Jiang J; Aster JC; Dumas JP; Pierce MC; Roblyer D
+Author NameID
+ Dumas, John Paul; ORCID: https://orcid.org/0000-0003-4724-2026
+ Roblyer, Darren; ORCID: https://orcid.org/0000-0002-5301-4364
+Authors Full Name
+ Zhao, Yanyu; Pilvar, Anahita; Tank, Anup; Peterson, Hannah; Jiang, John; Aster, Jon C; Dumas, John Paul; Pierce, Mark C; Roblyer, Darren.
+Institution
+ Zhao, Yanyu. Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA.
+ Zhao, Yanyu. Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
+ Pilvar, Anahita. Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA.
+ Tank, Anup. Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA.
+ Peterson, Hannah. Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA.
+ Jiang, John. Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA.
+ Aster, Jon C. Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
+ Dumas, John Paul. Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, NJ, 08854, USA.
+ Pierce, Mark C. Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, NJ, 08854, USA.
+ Roblyer, Darren. Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA. roblyer@bu.edu.
+MeSH Subject Headings
+ Adipose Tissue, Brown/dg [Diagnostic Imaging]
+ Adipose Tissue, Brown/pa [Pathology]
+ Adult
+ Animals
+ Biomarkers/bl [Blood]
+ Cardiovascular Diseases/dg [Diagnostic Imaging]
+ Edema/dg [Diagnostic Imaging]
+ Edema/pa [Pathology]
+ Female
+ Heterografts
+ Humans
+ Inflammation/dg [Diagnostic Imaging]
+ Inflammation/pa [Pathology]
+ *Infrared Rays
+ *Lipids/bl [Blood]
+ Male
+ Mice
+ Mice, Inbred BALB C
+ Mice, Inbred C57BL
+ Middle Aged
+ Neoplasms/dg [Diagnostic Imaging]
+ Neoplasms/pa [Pathology]
+ Obesity/dg [Diagnostic Imaging]
+ Optical Imaging/is [Instrumentation]
+ *Optical Imaging/mt [Methods]
+ Prostatic Neoplasms/dg [Diagnostic Imaging]
+ Prostatic Neoplasms/pa [Pathology]
+ *Radio Waves
+ Spectroscopy, Near-Infrared/is [Instrumentation]
+ *Spectroscopy, Near-Infrared/mt [Methods]
+ *Water/an [Analysis]
+Abstract
+ Water and lipids are key participants in many biological processes, but there are few non-invasive methods that provide quantification of these components in vivo, and none that can isolate and quantify lipids in the blood. Here we develop a new imaging modality termed shortwave infrared meso-patterned imaging (SWIR-MPI) to provide label-free, non-contact, spatial mapping of water and lipid concentrations in tissue. The method utilizes patterned hyperspectral illumination to target chromophore absorption bands in the 900-1,300 nm wavelength range. We use SWIR-MPI to monitor clinically important physiological processes including edema, inflammation, and tumor lipid heterogeneity in preclinical models. We also show that SWIR-MPI can spatially map blood-lipids in humans, representing an example of non-invasive and contact-free measurements of in vivo blood lipids. Together, these results highlight the potential of SWIR-MPI to enable new capabilities in fundamental studies and clinical monitoring of major conditions including obesity, cancer, and cardiovascular disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 059QF0KO0R (Water).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41467-020-19128-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhao&issn=2041-1723&title=Nature+communications+&atitle=Shortwave-infrared+meso-patterned+imaging+enables+label-free+mapping+of+tissue+water+and+lipid+content.&volume=11&issue=1&spage=5355&epage=&date=2020&doi=10.1038%2Fs41467-020-19128-7&pmid=33097705&sid=OVID:medline
+
+<1157>
+Unique Identifier
+ 33081045
+Title
+ The Cardiotonic Steroid Marinobufagenin Is a Predictor of Increased Left Ventricular Mass in Obesity: The African-PREDICT Study.
+Source
+ Nutrients. 12(10), 2020 Oct 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Strauss-Kruger M; Kruger R; Smith W; Gafane-Matemane LF; Mokwatsi G; Wei W; Fedorova OV; Schutte AE
+Author NameID
+ Strauss-Kruger, Michel; ORCID: https://orcid.org/0000-0003-0619-4654
+ Kruger, Ruan; ORCID: https://orcid.org/0000-0001-7680-2032
+ Smith, Wayne; ORCID: https://orcid.org/0000-0002-7101-7331
+ Gafane-Matemane, Lebo F; ORCID: https://orcid.org/0000-0003-4596-7218
+ Schutte, Aletta E; ORCID: https://orcid.org/0000-0001-9217-4937
+Authors Full Name
+ Strauss-Kruger, Michel; Kruger, Ruan; Smith, Wayne; Gafane-Matemane, Lebo F; Mokwatsi, Gontse; Wei, Wen; Fedorova, Olga V; Schutte, Aletta E.
+Institution
+ Strauss-Kruger, Michel. Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2520, South Africa.
+ Kruger, Ruan. Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2520, South Africa.
+ Kruger, Ruan. MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom 2520, South Africa.
+ Smith, Wayne. Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2520, South Africa.
+ Smith, Wayne. MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom 2520, South Africa.
+ Gafane-Matemane, Lebo F. Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2520, South Africa.
+ Gafane-Matemane, Lebo F. MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom 2520, South Africa.
+ Mokwatsi, Gontse. Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2520, South Africa.
+ Mokwatsi, Gontse. MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom 2520, South Africa.
+ Wei, Wen. National Institute on Aging, NIH, Baltimore, MD 212242, USA.
+ Fedorova, Olga V. National Institute on Aging, NIH, Baltimore, MD 212242, USA.
+ Schutte, Aletta E. Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2520, South Africa.
+ Schutte, Aletta E. MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom 2520, South Africa.
+ Schutte, Aletta E. School of Population Health, University of New South Wales, The George Institute for Global Health, Sydney 2052, Australia.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Biomarkers/ur [Urine]
+ Body Mass Index
+ *Bufanolides/ur [Urine]
+ *Cardiac Glycosides/ur [Urine]
+ *Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pa [Pathology]
+ *Eating/ph [Physiology]
+ Female
+ Heart Ventricles
+ Humans
+ Male
+ Obesity/co [Complications]
+ *Obesity/pa [Pathology]
+ Sodium Chloride, Dietary/ad [Administration & Dosage]
+ Sodium Chloride, Dietary/ae [Adverse Effects]
+ Sodium-Potassium-Exchanging ATPase/me [Metabolism]
+ *Ventricular Remodeling
+ Young Adult
+Keyword Heading
+ body mass index
+ cardiotonic steroids
+ dietary salt intake
+ left ventricular mass
+ marinobufagenin
+ obesity
+ young adults
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in animals. The adverse effects of MBG on cardiac remodeling may be exacerbated with obesity, due to an increased sensitivity of Na+/K+-ATPase to MBG. This study determined whether MBG is related to the change in LVMi over time in adults with a body mass index (BMI) >=30 kg/m2 (obese) and <30 kg/m2 (non-obese). The study followed 275 healthy participants (aged 20-30 years) from the African-Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT) study over 4.5 years. At baseline, we measured 24 h urine MBG excretion. MBG levels were positively associated with salt intake. LVMi was determined by two-dimensional echocardiography at baseline and after >4.5 years. With multivariate adjusted analyses in obese adults (N = 56), we found a positive association of follow-up LVMi (Adjusted (Adj.) R2 = 0.35; Std. beta = 0.311; p = 0.007) and percentage change in LVMi (Adj. R2 = 0.40; Std. beta = 0.336; p = 0.003) with baseline MBG excretion. No association of LVMi (Adj. R2 = 0.37; p = 0.85) or percentage change in LVMi (Adj. R2 = 0.19; p = 0.68) with MBG excretion was evident in normal weight adults (N = 123). These findings suggest that obese adults may be more sensitive to the adverse cardiac effects of MBG and provide new insight into the potential role of dietary salt, by way of MBG, in the pathogenesis of cardiac remodeling in obese individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Bufanolides). 0 (Cardiac Glycosides). 0 (Sodium Chloride, Dietary). 3KBT25GV2B (marinobufagenin). EC 7-2-2-13 (Sodium-Potassium-Exchanging ATPase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12103185
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Strauss-Kruger&issn=2072-6643&title=Nutrients&atitle=The+Cardiotonic+Steroid+Marinobufagenin+Is+a+Predictor+of+Increased+Left+Ventricular+Mass+in+Obesity%3A+The+African-PREDICT+Study.&volume=12&issue=10&spage=&epage=&date=2020&doi=10.3390%2Fnu12103185&pmid=33081045&sid=OVID:medline
+
+<1158>
+Unique Identifier
+ 33081030
+Title
+ Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 17(20), 2020 10 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rowicka G; Dylag H; Chelchowska M; Weker H; Ambroszkiewicz J
+Author NameID
+ Chelchowska, Magdalena; ORCID: https://orcid.org/0000-0002-6174-6813
+ Ambroszkiewicz, Jadwiga; ORCID: https://orcid.org/0000-0001-7320-7561
+Authors Full Name
+ Rowicka, Grazyna; Dylag, Hanna; Chelchowska, Magdalena; Weker, Halina; Ambroszkiewicz, Jadwiga.
+Institution
+ Rowicka, Grazyna. Department of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland.
+ Dylag, Hanna. Department of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland.
+ Chelchowska, Magdalena. Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland.
+ Weker, Halina. Department of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland.
+ Ambroszkiewicz, Jadwiga. Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ *Chemokines/bl [Blood]
+ Chemokines/me [Metabolism]
+ Child
+ Child, Preschool
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ *Intercellular Signaling Peptides and Proteins/bl [Blood]
+ *Leukocyte L1 Antigen Complex/bl [Blood]
+ Leukocyte L1 Antigen Complex/me [Metabolism]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/im [Immunology]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Puberty
+Keyword Heading
+ calprotectin
+ chemerin
+ chronic low-grade inflammation
+ obesity
+ prepubertal children
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In adults, obesity is associated with chronic low-grade inflammation, which may cause long-term adverse health consequences. We evaluated whether obesity in prepubertal children also generates this kind of inflammation and whether calprotectin and chemerin may be useful markers for early detection of such inflammation in this group of children. The study population included 83 children aged 2 to 10 years; 62 with obesity and without components of metabolic syndrome and 21 healthy controls with normal body weight. White blood cell (WBC) count, concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), calprotectin, and chemerin were determined in peripheral blood. Our study showed that in the group with obesity, serum concentrations of calprotectin and chemerin, as well as CRP were significantly higher as compared with the controls. We found a significant positive correlation between serum chemerin concentrations and BMI z-score (r = 0.33, p < 0.01) in children with obesity. Chemerin concentration was also positively correlated with CRP level (r = 0.36, p < 0.01) in the whole group of children. These findings suggest that obesity may generate chronic low-grade inflammation as early as in the prepubertal period which can be indicated by significantly higher serum concentrations of calprotectin and chemerin. Calprotectin and especially chemerin seem to be promising indicators of this type of inflammation in children with obesity, but the correlation between these markers requires further research.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Chemokines). 0 (Intercellular Signaling Peptides and Proteins). 0 (Leukocyte L1 Antigen Complex). 0 (RARRES2 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijerph17207575
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rowicka&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Serum+Calprotectin+and+Chemerin+Concentrations+as+Markers+of+Low-Grade+Inflammation+in+Prepubertal+Children+with+Obesity.&volume=17&issue=20&spage=&epage=&date=2020&doi=10.3390%2Fijerph17207575&pmid=33081030&sid=OVID:medline
+
+<1159>
+Unique Identifier
+ 33077739
+Title
+ Pre-diagnostic biomarkers of type 2 diabetes identified in the UAE's obese national population using targeted metabolomics.
+Source
+ Scientific Reports. 10(1):17616, 2020 10 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fikri AM; Smyth R; Kumar V; Al-Abadla Z; Abusnana S; Munday MR
+Authors Full Name
+ Fikri, Asma M; Smyth, Rosemary; Kumar, Vijay; Al-Abadla, Zainab; Abusnana, Salahedeen; Munday, Michael R.
+Institution
+ Fikri, Asma M. Ministry of Health and Prevention, Dubai, UAE. dr.asma.fikri@gmail.com.
+ Fikri, Asma M. Rahsid Centre for Diabetes and Research, Ajman, UAE. dr.asma.fikri@gmail.com.
+ Smyth, Rosemary. Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, UK.
+ Kumar, Vijay. Rahsid Centre for Diabetes and Research, Ajman, UAE.
+ Al-Abadla, Zainab. Rahsid Centre for Diabetes and Research, Ajman, UAE.
+ Abusnana, Salahedeen. Rahsid Centre for Diabetes and Research, Ajman, UAE.
+ Munday, Michael R. Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, UK. michael.munday@ucl.ac.uk.
+MeSH Subject Headings
+ 3-Hydroxybutyric Acid/bl [Blood]
+ Adult
+ Alanine/bl [Blood]
+ Amino Acids, Branched-Chain/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Chromatography, Liquid
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Female
+ Humans
+ Male
+ Metabolomics
+ Methylamines/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Tandem Mass Spectrometry
+ United Arab Emirates
+ Uric Acid/bl [Blood]
+ Young Adult
+Abstract
+ Currently, type 2 diabetes mellitus (T2DM) and obesity are major global public health issues, and their prevalence in the United Arab Emirates (UAE) are among the highest in the world. In 2019, The UAE diabetes national prevalence was 15.4%. In recent years there has been a considerable investigation of predictive biomarkers associated with these conditions. This study analysed fasting (8 h) blood samples from an obese, normoglycemic cohort and an obese, T2DM cohort of UAE nationals, employing clinical chemistry analysis, 1D 1H NMR and mass spectroscopy (FIA-MS/MS and LC-MS/MS) techniques. The novel findings reported for the first time in a UAE population revealed significant differences in a number of metabolites in the T2DM cohort. Metabolic fingerprints identified by NMR included BCAAs, trimethylamine N-oxide, beta-hydroxybutyrate, trimethyl uric acid, and alanine. A targeted MS approach showed significant differences in lysophosphatidylcholines, phosphatidylcholines, acylcarnitine, amino acids and sphingomyelins; Lyso.PC.a.C18.0, PC.ae.C34.2, C3.DC..C4.OH, glutamine and SM.C16.1, being the most significant metabolites. Pearson's correlation studies showed associations between these metabolites and the clinical chemistry parameters across both cohorts. This report identified differences in metabolites in response to T2DM in agreement with many published population studies. This contributes to the global search for a bank of metabolite biomarkers that can predict the advent of T2DM and give insight to its pathogenic mechanisms.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers). 0 (Methylamines). 268B43MJ25 (Uric Acid). FLD0K1SJ1A (trimethyloxamine). OF5P57N2ZX (Alanine). TZP1275679 (3-Hydroxybutyric Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-73384-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fikri&issn=2045-2322&title=Scientific+Reports&atitle=Pre-diagnostic+biomarkers+of+type+2+diabetes+identified+in+the+UAE%27s+obese+national+population+using+targeted+metabolomics.&volume=10&issue=1&spage=17616&epage=&date=2020&doi=10.1038%2Fs41598-020-73384-7&pmid=33077739&sid=OVID:medline
+
+<1160>
+Unique Identifier
+ 33073494
+Title
+ An in silico approach to identify and prioritize miRNAs target sites polymorphisms in colorectal cancer and obesity.
+Source
+ Cancer Medicine. 9(24):9511-9528, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gholami M; Zoughi M; Larijani B; M Amoli M; Bastami M
+Author NameID
+ Gholami, Morteza; ORCID: https://orcid.org/0000-0003-0952-0654
+ Larijani, Bagher; ORCID: https://orcid.org/0000-0001-5386-7597
+ M Amoli, Mahsa; ORCID: https://orcid.org/0000-0002-9168-9223
+ Bastami, Milad; ORCID: https://orcid.org/0000-0002-7686-4505
+Authors Full Name
+ Gholami, Morteza; Zoughi, Marzieh; Larijani, Bagher; M Amoli, Mahsa; Bastami, Milad.
+Institution
+ Gholami, Morteza. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Gholami, Morteza. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Zoughi, Marzieh. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Larijani, Bagher. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ M Amoli, Mahsa. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Bastami, Milad. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ *Colorectal Neoplasms/ge [Genetics]
+ Colorectal Neoplasms/me [Metabolism]
+ Colorectal Neoplasms/pa [Pathology]
+ *Computational Biology/mt [Methods]
+ Computer Simulation
+ Databases, Genetic
+ Genome-Wide Association Study/mt [Methods]
+ Humans
+ *MicroRNAs/ge [Genetics]
+ *Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Polymorphism, Single Nucleotide
+ Prognosis
+ *RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+Keyword Heading
+ bioinformatics
+ biomarkers
+ colorectal cancer
+ polymorphisms
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Colorectal cancer (CRC) and obesity are linked clinical entities with a series of complex processes being engaged in their development. MicroRNAs (miRNAs) participate in these processes through regulating CRC and obesity-related genes. This study aimed to develop an in silico approach to systematically identify and prioritize miRNAs target sites polymorphisms in obesity and CRC. Data from genome-wide association studies (GWASs) were used to retrieve CRC and obesity-associated variants. The polymorphisms that were resided in experimentally verified or computationally predicted miRNA target sites were retrieved and prioritized using a range of bioinformatics analyses. We found 6284 CRC and 38931 obesity unique variants. For CRC 33 haplotypes variants in 134 interactions were in miRNA targetome, while for obesity we found more than 935 unique interactions. Functionally prioritized SNPs revealed that, SNPs in 153 obesity and 50 CRC unique interactions were have disruptive effects on miRNA:mRNA integration by changing on target RNA secondary structure. Structural accessibility of target sites were decreased in 418 and 103 unique interactions and increased in 516 and 79 interactions, for obesity and CRC, respectively. The miRNA:mRNA hybrid stability was increased in 127 and 17 unique interactions and decreased in 33 and 24 interactions for the effect of obesity and CRC SNPs, respectively. In this study, seven SNPs with 15 interactions and three SNPs with four interactions were prioritized for obesity and CRC, respectively. These SNPs could be used for future studies for finding potential biomarkers for diagnoses, prognosis, or treatment of CRC and obesity. Copyright © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs). 0 (RNA, Messenger).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1002%2fcam4.3546
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gholami&issn=2045-7634&title=Cancer+Medicine&atitle=An+in+silico+approach+to+identify+and+prioritize+miRNAs+target+sites+polymorphisms+in+colorectal+cancer+and+obesity.&volume=9&issue=24&spage=9511&epage=9528&date=2020&doi=10.1002%2Fcam4.3546&pmid=33073494&sid=OVID:medline
+
+<1161>
+Unique Identifier
+ 33071964
+Title
+ Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity.
+Source
+ Frontiers in Endocrinology. 11:654, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tas E; Bai S; Ou X; Mercer K; Lin H; Mansfield K; Buchmann R; Diaz EC; Oden J; Borsheim E; Adams SH; Dranoff J
+Authors Full Name
+ Tas, Emir; Bai, Shasha; Ou, Xiawei; Mercer, Kelly; Lin, Haixia; Mansfield, Kori; Buchmann, Robert; Diaz, Eva C; Oden, Jon; Borsheim, Elisabet; Adams, Sean H; Dranoff, Jonathan.
+Institution
+ Tas, Emir. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Tas, Emir. Endocrinology and Diabetes, Arkansas Children's Hospital, Little Rock, AR, United States.
+ Tas, Emir. Arkansas Children's Research Institute, Little Rock, AR, United States.
+ Tas, Emir. Arkansas Children's Nutrition Center, Little Rock, AR, United States.
+ Bai, Shasha. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Bai, Shasha. Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
+ Ou, Xiawei. Arkansas Children's Nutrition Center, Little Rock, AR, United States.
+ Ou, Xiawei. Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Mercer, Kelly. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Mercer, Kelly. Arkansas Children's Research Institute, Little Rock, AR, United States.
+ Mercer, Kelly. Arkansas Children's Nutrition Center, Little Rock, AR, United States.
+ Lin, Haixia. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Lin, Haixia. Arkansas Children's Nutrition Center, Little Rock, AR, United States.
+ Mansfield, Kori. Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Buchmann, Robert. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Buchmann, Robert. Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Diaz, Eva C. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Diaz, Eva C. Arkansas Children's Research Institute, Little Rock, AR, United States.
+ Diaz, Eva C. Arkansas Children's Nutrition Center, Little Rock, AR, United States.
+ Oden, Jon. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Oden, Jon. Endocrinology and Diabetes, Arkansas Children's Hospital, Little Rock, AR, United States.
+ Oden, Jon. Arkansas Children's Research Institute, Little Rock, AR, United States.
+ Borsheim, Elisabet. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Borsheim, Elisabet. Arkansas Children's Research Institute, Little Rock, AR, United States.
+ Borsheim, Elisabet. Arkansas Children's Nutrition Center, Little Rock, AR, United States.
+ Adams, Sean H. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+ Adams, Sean H. Arkansas Children's Research Institute, Little Rock, AR, United States.
+ Adams, Sean H. Arkansas Children's Nutrition Center, Little Rock, AR, United States.
+ Dranoff, Jonathan. Arkansas Children's Research Institute, Little Rock, AR, United States.
+ Dranoff, Jonathan. Department of Medicine, Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adolescent
+ Biomarkers/bl [Blood]
+ Child
+ Female
+ *Fibroblast Growth Factors/bl [Blood]
+ Humans
+ Liver/dg [Diagnostic Imaging]
+ Magnetic Resonance Imaging
+ Male
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ *Obesity/bl [Blood]
+ Obesity/dg [Diagnostic Imaging]
+ *Triglycerides/bl [Blood]
+Keyword Heading
+ adiponectin
+ childhood obesity
+ fibroblast growth factor-21
+ intrahepatic triglyceride
+ leptin
+ magnetic resonace imaging (MRI)
+ non-alcoholic fatty liver disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: There is a pressing need for effective and non-invasive biomarkers to track intrahepatic triglyceride (IHTG) in children at-risk for non-alcoholic fatty liver disease (NAFLD), as standard-of-care reference tools, liver biopsy and magnetic resonance imaging (MRI), are impractical to monitor the course disease. Objective: We aimed to examine the association between serum fibroblast growth factor (FGF)-21 to adiponectin ratio (FAR) and IHTG as assessed by MRI in children with obesity. Methods: Serum FGF21 and adiponectin levels and IHTG were measured at two time points (baseline, 6 months) in obese children enrolled in a clinical weight loss program. The association between percent change in FAR and IHTG at final visit was examined using a multiple linear regression model. Results: At baseline, FAR was higher in the subjects with NAFLD (n = 23, 35.8 +/- 41.9 pg/ng) than without NAFLD (n = 35, 19.8 +/- 13.7 pg/ng; p = 0.042). Forty-eight subjects completed both visits and were divided into IHTG loss (>=1% reduction than baseline), no change (within +/-1% change), and gain (>=1% increase than baseline) groups. At 6 months, the percent change in FAR was different among the three groups (p = 0.005). Multiple linear regression showed a positive relationship between percent change in FAR and the final liver fat percent in sex and pubertal stage-similar subjects with NAFLD at baseline (slope coefficient 6.18, 95% CI 1.90-10.47, P = 0.007), but not in those without NAFLD. Conclusions: Higher value in percent increase in FAR is positively associated with higher level of IHTG percent value at 6 months in children with baseline NAFLD. FAR could be a potential biomarker to monitor the changes in IHTG in children with NAFLD. Copyright © 2020 Tas, Bai, Ou, Mercer, Lin, Mansfield, Buchmann, Diaz, Oden, Borsheim, Adams and Dranoff.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (FGF21 protein, human). 0 (Triglycerides). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffendo.2020.00654
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tas&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Fibroblast+Growth+Factor-21+to+Adiponectin+Ratio%3A+A+Potential+Biomarker+to+Monitor+Liver+Fat+in+Children+With+Obesity.&volume=11&issue=&spage=654&epage=&date=2020&doi=10.3389%2Ffendo.2020.00654&pmid=33071964&sid=OVID:medline
+
+<1162>
+Unique Identifier
+ 33050482
+Title
+ Early Pro-Inflammatory Remodeling of HDL Proteome in a Model of Diet-Induced Obesity: 2H2O-Metabolic Labeling-Based Kinetic Approach.
+Source
+ International Journal of Molecular Sciences. 21(20), 2020 Oct 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sadana P; Lin L; Aghayev M; Ilchenko S; Kasumov T
+Author NameID
+ Aghayev, Mirjavid; ORCID: https://orcid.org/0000-0003-0588-4450
+Authors Full Name
+ Sadana, Prabodh; Lin, Li; Aghayev, Mirjavid; Ilchenko, Serguei; Kasumov, Takhar.
+Institution
+ Sadana, Prabodh. Department of Pharmacy Practice, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
+ Lin, Li. Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
+ Aghayev, Mirjavid. Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
+ Ilchenko, Serguei. Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
+ Kasumov, Takhar. Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Diet/ae [Adverse Effects]
+ *Diet
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Disease Susceptibility
+ *Lipoproteins, HDL/me [Metabolism]
+ Male
+ Mass Spectrometry
+ Mice
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/di [Diagnosis]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Protein Interaction Mapping
+ Protein Interaction Maps
+ *Proteome
+ Proteomics/mt [Methods]
+ *Proteomics
+Keyword Heading
+ NAFLD
+ acute-phase proteins
+ diet-induced obesity
+ dyslipidemia
+ high-density lipoprotein
+ high-fat diet
+ inflammation
+ insulin resistance
+ proteome dynamics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Mice fed a high-fat diet for 12 weeks or longer develop hyperglycemia, insulin resistance, dyslipidemia, and fatty liver. Additionally, a high-fat diet induces inflammation that remodels and affects the anti-inflammatory and antiatherogenic property of the high-density lipoprotein (HDL). However, the precise time course of metabolic disease progression and HDL remodeling remains unclear. Short-term (four weeks) high-fat feeding (60% fat calories) was performed in wild-type male C57BL/6J mice to gain insights into the early metabolic disease processes in conjunction with a HDL proteome dynamics analysis using a heavy water metabolic labeling approach. The high-fat diet-fed mice developed hyperglycemia, impaired glucose tolerance, hypercholesterolemia without hypertriglyceridemia or hepatic steatosis. A plasma HDL proteome dynamics analysis revealed increased turnover rates (and reduced half-lives) of several acute-phase response proteins involved in innate immunity, including complement C3 (12.77 +/- 0.81 vs. 9.98 +/- 1.20 h, p < 0.005), complement factor B (12.71 +/- 1.01 vs. 10.85 +/- 1.04 h, p < 0.05), complement Factor H (19.60 +/- 1.84 vs. 16.80 +/- 1.58 h, p < 0.05), and complement factor I (25.25 +/- 1.29 vs. 19.88 +/- 1.50 h, p < 0.005). Our findings suggest that an early immune response-induced inflammatory remodeling of the plasma HDL proteome precedes the diet-induced steatosis and dyslipidemia.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipoproteins, HDL). 0 (Proteome).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21207472
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sadana&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Early+Pro-Inflammatory+Remodeling+of+HDL+Proteome+in+a+Model+of+Diet-Induced+Obesity%3A+2H2O-Metabolic+Labeling-Based+Kinetic+Approach.&volume=21&issue=20&spage=7472&epage=&date=2020&doi=10.3390%2Fijms21207472&pmid=33050482&sid=OVID:medline
+
+<1163>
+Unique Identifier
+ 33047256
+Title
+ Microalbuminuria and Serum Cystatin C: Biomarkers for Early Detection of Kidney Injury in Children with Obesity.
+Source
+ Indian Journal of Pediatrics. 87(12):991-992, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mishra OP; Prasad R
+Author NameID
+ Mishra, Om P; ORCID: https://orcid.org/0000-0001-6692-7392
+Authors Full Name
+ Mishra, Om P; Prasad, Rajniti.
+Institution
+ Mishra, Om P. Division of Pediatric Nephrology, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. opmpedia@yahoo.co.uk.
+ Prasad, Rajniti. Division of Pediatric Nephrology, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Biomarkers
+ Child
+ *Cystatin C
+ Humans
+ Kidney
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Renal Insufficiency
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cystatin C).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs12098-020-03526-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mishra&issn=0019-5456&title=Indian+Journal+of+Pediatrics&atitle=Microalbuminuria+and+Serum+Cystatin+C%3A+Biomarkers+for+Early+Detection+of+Kidney+Injury+in+Children+with+Obesity.&volume=87&issue=12&spage=991&epage=992&date=2020&doi=10.1007%2Fs12098-020-03526-2&pmid=33047256&sid=OVID:medline
+
+<1164>
+Unique Identifier
+ 33046375
+Title
+ The proportion of cleaved anti-Mullerian hormone is higher in serum but not follicular fluid of obese women independently of polycystic ovary syndrome.
+Source
+ Reproductive Biomedicine Online. 41(6):1112-1121, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Peigne M; Pigny P; Pankhurst MW; Drumez E; Loyens A; Dewailly D; Catteau-Jonard S; Giacobini P
+Authors Full Name
+ Peigne, Maeliss; Pigny, Pascal; Pankhurst, Michael W; Drumez, Elodie; Loyens, Anne; Dewailly, Didier; Catteau-Jonard, Sophie; Giacobini, Paolo.
+Institution
+ Peigne, Maeliss. Universite de Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille F-59000, France; AP-HP- Universite Sorbonne Paris-Nord, Service de Medecine de la Reproduction et Preservation de la Fertilite, Hopital Jean Verdier, Bondy F-93143, France; CHU Lille, Service de Gynecologie Medicale, Hopital Jeanne de Flandre, Lille F-59000, France. Electronic address: maeliss.peigne@inserm.fr.
+ Pigny, Pascal. Universite de Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille F-59000, France; CHU Lille, Service de Biochimie et Hormonologie, Centre de Biologie Pathologie, Lille F-59000, France.
+ Pankhurst, Michael W. Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
+ Drumez, Elodie. Universite de Lille, CHU Lille, ULR 2694 - METRICS: Evaluation des technologies de sante et des pratiques medicales, Lille F-59000, France; CHU Lille, Department of Biostatistics, F-59000 Lille, France HU Lille, Unite de Methodologie - Biostatistique et Data Management, Lille F-59000, France.
+ Loyens, Anne. Universite de Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille F-59000, France.
+ Dewailly, Didier. Universite de Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille F-59000, France; CHU Lille, Service de Gynecologie Medicale, Hopital Jeanne de Flandre, Lille F-59000, France.
+ Catteau-Jonard, Sophie. Universite de Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille F-59000, France; CHU Lille, Service de Gynecologie Medicale, Hopital Jeanne de Flandre, Lille F-59000, France.
+ Giacobini, Paolo. Universite de Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille F-59000, France. Electronic address: paolo.giacobini@inserm.fr.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Anti-Mullerian Hormone/bl [Blood]
+ Anti-Mullerian Hormone/ch [Chemistry]
+ *Anti-Mullerian Hormone/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ Female
+ Follicular Fluid/ch [Chemistry]
+ *Follicular Fluid/me [Metabolism]
+ France/ep [Epidemiology]
+ Humans
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ *Obesity/me [Metabolism]
+ Polycystic Ovary Syndrome/co [Complications]
+ Polycystic Ovary Syndrome/ep [Epidemiology]
+ *Polycystic Ovary Syndrome/me [Metabolism]
+ Protein Isoforms/an [Analysis]
+ Protein Isoforms/bl [Blood]
+ Protein Isoforms/me [Metabolism]
+ Protein Precursors/bl [Blood]
+ Protein Precursors/me [Metabolism]
+ Young Adult
+Keyword Heading
+ AMH
+ BMI
+ Follicular fluid
+ Molecular forms
+ Obesity
+ PCOS
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ RESEARCH QUESTION: Does the relative distribution of anti-Mullerian hormone (AMH) isoforms differ between patients depending on their body mass index (BMI) and polycystic ovary syndrome (PCOS) status in serum and follicular fluid?
+
+ DESIGN: Obese and normal weight patients (PCOS [n=70]; non-PCOS [n=37]) were selected for this case-control study in the serum. Between 2018 and 2019, obese (n=19) and normal weight (n=20) women with or without PCOS who were receiving IVF treatment were included in the follicular fluid study. The bio-banked serums and follicular fluid were tested for total AMH (proAMH and AMHN,C combined) and proAMH using an automatic analyzer. The AMH prohormone index (API=[proAMH]/[total AMH]x 100) was calculated as an inverse marker of conversion of proAMH to AMHN,C, with only the latter isoform that could bind to the AMH receptor complex.
+
+ RESULTS: The API was not significantly different between controls and women with PCOS, whereas obese women had a lower API compared with their normal weight counterparts. Grouping PCOS and controls, a lower API was found in obese versus normal weight women, suggesting a greater conversion of proAMH to AMHN,C. The API in the serum was significantly correlated with metabolic parameters. In the follicular fluid, API is not different between obese and normal weight women independently of PCOS and is higher than in the concomitant serum.
+
+ CONCLUSIONS: The proportion of inactive form of AMH in the serum is higher in normal weight versus obese women but not in the follicular fluid, independently of PCOS. The conversion of proAMH into the cleaved isoform is likely to occur in extra-ovarian tissues and to exacerbate in obese individuals. Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Protein Isoforms). 0 (Protein Precursors). 80497-65-0 (Anti-Mullerian Hormone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.rbmo.2020.07.020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Peigne&issn=1472-6483&title=Reproductive+Biomedicine+Online&atitle=The+proportion+of+cleaved+anti-Mullerian+hormone+is+higher+in+serum+but+not+follicular+fluid+of+obese+women+independently+of+polycystic+ovary+syndrome.&volume=41&issue=6&spage=1112&epage=1121&date=2020&doi=10.1016%2Fj.rbmo.2020.07.020&pmid=33046375&sid=OVID:medline
+
+<1165>
+Unique Identifier
+ 33040225
+Title
+ Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk. [Review]
+Source
+ Current Cardiology Reports. 22(12):174, 2020 10 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Regan JA; Shah SH
+Authors Full Name
+ Regan, Jessica A; Shah, Svati H.
+Institution
+ Regan, Jessica A. Department of Medicine, Duke University, Durham, NC, USA.
+ Regan, Jessica A. Duke Molecular Physiology Institute, Duke University, 300 N. Duke Street, DUMC, Box 104775, Durham, NC, 27701, USA.
+ Shah, Svati H. Department of Medicine, Duke University, Durham, NC, USA. svati.shah@duke.edu.
+ Shah, Svati H. Duke Molecular Physiology Institute, Duke University, 300 N. Duke Street, DUMC, Box 104775, Durham, NC, 27701, USA. svati.shah@duke.edu.
+MeSH Subject Headings
+ Amino Acids, Branched-Chain
+ Biomarkers
+ Cardiovascular Diseases/ge [Genetics]
+ *Cardiovascular Diseases
+ Genomics
+ Humans
+ Metabolomics
+ Obesity/ge [Genetics]
+ *Obesity
+Keyword Heading
+ Branched-chain amino acids
+ Cardiometabolic
+ Genomics
+ Metabolomics
+ Obesity
+ Polygenic risk score
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE OF REVIEW: Obesity is a significant international public health epidemic with major downstream consequences on morbidity and mortality. While lifestyle factors contribute, there is an evolving understanding of genomic and metabolomic pathways involved with obesity and its relationship with cardiometabolic risk. This review will provide an overview of some of these important findings from both a biologic and clinical perspective.
+
+ RECENT FINDINGS: Recent studies have identified polygenic risk scores and metabolomic biomarkers of obesity and related outcomes, which have also highlighted biological pathways, such as the branched-chain amino acid (BCAA) pathway that is dysregulated in this disease. These biomarkers may help in personalizing obesity interventions and for mitigation of future cardiometabolic risk. A multifaceted approach is necessary to impact the growing epidemic of obesity and related diseases. This will likely include incorporating precision medicine approaches with genomic and metabolomic biomarkers to personalize interventions and improve risk prediction.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs11886-020-01422-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Regan&issn=1523-3782&title=Current+Cardiology+Reports&atitle=Obesity+Genomics+and+Metabolomics%3A+a+Nexus+of+Cardiometabolic+Risk.&volume=22&issue=12&spage=174&epage=&date=2020&doi=10.1007%2Fs11886-020-01422-x&pmid=33040225&sid=OVID:medline
+
+<1166>
+Unique Identifier
+ 33028503
+Title
+ Impact of bariatric surgery-induced weight loss on circulating PCSK9 levels in obese patients.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(12):2372-2378, 2020 11 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zenti MG; Lupo MG; De Martin S; Altomari A; Galvan S; Aventaggiato M; Maneschi C; Sandri D; Paiola E; Battistoni M; Eccher A; Targher G; Bonora E; Ruscica M; Ferri N
+Authors Full Name
+ Zenti, Maria G; Lupo, Maria G; De Martin, Sara; Altomari, Anna; Galvan, Serena; Aventaggiato, Marta; Maneschi, Chiara; Sandri, Damiano; Paiola, Elena; Battistoni, Marco; Eccher, Albino; Targher, Giovanni; Bonora, Enzo; Ruscica, Massimiliano; Ferri, Nicola.
+Institution
+ Zenti, Maria G. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Lupo, Maria G. Dipartimento di Scienze del Farmaco, Universita degli Studi di Padova, Padua, Italy.
+ De Martin, Sara. Dipartimento di Scienze del Farmaco, Universita degli Studi di Padova, Padua, Italy.
+ Altomari, Anna. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Galvan, Serena. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Aventaggiato, Marta. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Maneschi, Chiara. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Sandri, Damiano. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Paiola, Elena. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Battistoni, Marco. Division of Bariatric Surgery, University Hospital of Verona, Verona, Italy.
+ Eccher, Albino. Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
+ Targher, Giovanni. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Bonora, Enzo. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and University Hospital of Verona, Verona, Italy.
+ Ruscica, Massimiliano. Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy.
+ Ferri, Nicola. Dipartimento di Scienze del Farmaco, Universita degli Studi di Padova, Padua, Italy. Electronic address: nicola.ferri@unipd.it.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ Female
+ *Gastrectomy
+ *Gastric Bypass
+ Glucose Tolerance Test
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/su [Surgery]
+ Pilot Projects
+ *Proprotein Convertase 9/bl [Blood]
+ Time Factors
+ Treatment Outcome
+ *Weight Loss
+ Young Adult
+Keyword Heading
+ Adipose tissue
+ Bariatric
+ Glucose
+ OGTT
+ PCSK9
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: To investigate the effect of obesity and bariatric-induced weight loss on circulating levels of proprotein convertase subtilisin/kexin 9 (PCSK9) in severely obese patients.
+
+ METHODS AND RESULTS: In this non-randomized interventional study, we enrolled 36 severely obese patients (BMI 43.7 +/- 5.6 kg/m2), of which 20 underwent bariatric surgery, and 12 nonobese healthy controls. An oral glucose tolerance test (75-g OGTT) was performed in 31 of these obese patients at baseline (T0) and in 14 patients at 6 months after bariatric surgery (T6) to assess plasma glucose, insulin and PCSK9 levels. Plasma PCSK9 levels were also measured in 18 of these obese patients at T0 during a 2-h hyperinsulinemic-euglycemic clamp (HEC). At T0, PCSK9 levels were higher in obese patients than in controls (274.6 +/- 76.7 ng/mL vs. 201.4 +/- 53.3 ng/mL) and dropped after bariatric surgery (T6; 205.5 +/- 51.7 ng/mL) along with BMI (from 44.1 +/- 5.9 kg/m2 to 33.1 +/- 5.6 kg/m2). At T6, there was also a decrease in plasma glucose (T0 vs. T6: 6.0 +/- 1.8 vs. 5.0 +/- 0.5 mmol/L) and insulin (15.7 +/- 8.3 vs. 5.4 +/- 2.1 mU/L) levels. At T0, plasma PCSK9 levels decreased during OGTT in obese patients, reaching a nadir of 262.0 +/- 61.4 ng/mL at 120 min with a hyperinsulinemic peak of 75.1 +/- 40.0 mU/L, at 60 min. Similarly, at T0 insulin infusion during 2-h HEC acutely reduced plasma PCSK9 levels in obese patients. The aforementioned OGTT-induced changes in plasma PCSK9 levels were not observed neither in nonobese healthy controls nor in obese patients after bariatric-surgery weight loss.
+
+ CONCLUSIONS: These results suggest a pivotal role of adipose tissue and insulin resistance on PCSK9 homeostasis in severely obese patients. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). EC 3-4-21 (PCSK9 protein, human). EC 3-4-21 (Proprotein Convertase 9).
+Publication Type
+ Clinical Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.numecd.2020.07.013
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zenti&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Impact+of+bariatric+surgery-induced+weight+loss+on+circulating+PCSK9+levels+in+obese+patients.&volume=30&issue=12&spage=2372&epage=2378&date=2020&doi=10.1016%2Fj.numecd.2020.07.013&pmid=33028503&sid=OVID:medline
+
+<1167>
+Unique Identifier
+ 33020474
+Title
+ Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD.
+Source
+ Nature communications . 11(1):4982, 2020 10 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee G; You HJ; Bajaj JS; Joo SK; Yu J; Park S; Kang H; Park JH; Kim JH; Lee DH; Lee S; Kim W; Ko G
+Author NameID
+ Lee, Giljae; ORCID: http://orcid.org/0000-0002-3971-9712
+ Bajaj, Jasmohan S; ORCID: http://orcid.org/0000-0003-4928-3681
+ Lee, Dong Hyeon; ORCID: http://orcid.org/0000-0003-2044-6854
+ Kim, Won; ORCID: http://orcid.org/0000-0002-2926-1007
+ Ko, GwangPyo; ORCID: http://orcid.org/0000-0002-0524-2194
+Authors Full Name
+ Lee, Giljae; You, Hyun Ju; Bajaj, Jasmohan S; Joo, Sae Kyung; Yu, Junsun; Park, Seoyeon; Kang, Hyena; Park, Jeong Hwan; Kim, Jung Ho; Lee, Dong Hyeon; Lee, Seonhwa; Kim, Won; Ko, GwangPyo.
+Institution
+ Lee, Giljae. Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
+ You, Hyun Ju. Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
+ You, Hyun Ju. Institute of Health and Environment, Seoul National University, Seoul, 08826, Republic of Korea.
+ You, Hyun Ju. Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, Seoul, 08826, Republic of Korea.
+ Bajaj, Jasmohan S. Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, 23249, USA.
+ Joo, Sae Kyung. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061, Republic of Korea.
+ Yu, Junsun. Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
+ Park, Seoyeon. Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
+ Kang, Hyena. Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
+ Park, Jeong Hwan. Department of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061, Republic of Korea.
+ Kim, Jung Ho. Department of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061, Republic of Korea.
+ Lee, Dong Hyeon. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061, Republic of Korea.
+ Lee, Seonhwa. Department of Bio-convergence Engineering, Korea University, Seoul, 02841, Republic of Korea.
+ Kim, Won. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061, Republic of Korea. drwon1@snu.ac.kr.
+ Ko, GwangPyo. Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea. gko@snu.ac.kr.
+ Ko, GwangPyo. Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, Seoul, 08826, Republic of Korea. gko@snu.ac.kr.
+ Ko, GwangPyo. KoBioLabs, Inc., Seoul, 08826, Republic of Korea. gko@snu.ac.kr.
+ Ko, GwangPyo. Bio-MAX/N-Bio, Seoul National University, Seoul, 08826, Republic of Korea. gko@snu.ac.kr.
+MeSH Subject Headings
+ Animals
+ Bacteria/cl [Classification]
+ Bacteria/ge [Genetics]
+ *Bacteria/ip [Isolation & Purification]
+ Bacteria/me [Metabolism]
+ Bile Acids and Salts/an [Analysis]
+ Bile Acids and Salts/me [Metabolism]
+ Biomarkers
+ Feces/ch [Chemistry]
+ Feces/mi [Microbiology]
+ Fibrosis
+ Gastrointestinal Microbiome/ge [Genetics]
+ *Gastrointestinal Microbiome/ph [Physiology]
+ Humans
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/me [Metabolism]
+ Liver Cirrhosis/mi [Microbiology]
+ Liver Cirrhosis/pa [Pathology]
+ Mice
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/mi [Microbiology]
+ *Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/me [Metabolism]
+ Obesity/mi [Microbiology]
+ Obesity/pa [Pathology]
+ Propionates/an [Analysis]
+ Propionates/me [Metabolism]
+ RNA, Ribosomal, 16S/ge [Genetics]
+ Reproducibility of Results
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or fibrosis severity. Significant alterations in microbiome diversity are observed according to fibrosis severity in non-obese, but not obese, subjects. Ruminococcaceae and Veillonellaceae are the main microbiota associated with fibrosis severity in non-obese subjects. Furthermore, stool bile acids and propionate are elevated, especially in non-obese subjects with significant fibrosis. Fibrosis-related Ruminococcaceae and Veillonellaceae species undergo metagenome sequencing, and four representative species are administered in three mouse NAFLD models to evaluate their effects on liver damage. This study provides the evidence for the role of the microbiome in the liver fibrosis pathogenesis, especially in non-obese subjects.
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers). 0 (Propionates). 0 (RNA, Ribosomal, 16S).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41467-020-18754-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=2041-1723&title=Nature+communications+&atitle=Distinct+signatures+of+gut+microbiome+and+metabolites+associated+with+significant+fibrosis+in+non-obese+NAFLD.&volume=11&issue=1&spage=4982&epage=&date=2020&doi=10.1038%2Fs41467-020-18754-5&pmid=33020474&sid=OVID:medline
+
+<1168>
+Unique Identifier
+ 33011149
+Title
+ Physical Fitness but Not Diet Quality Distinguishes Lean and Normal Weight Obese Adults.
+Source
+ Journal of the Academy of Nutrition & Dietetics. 120(12):1963-1973.e2, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bellissimo MP; Bettermann EL; Tran PH; Crain BH; Ferranti EP; Binongo JN; Hartman TJ; Jones DP; Ziegler TR; Alvarez JA
+Authors Full Name
+ Bellissimo, Moriah P; Bettermann, Erika L; Tran, Phong H; Crain, Benjamin H; Ferranti, Erin P; Binongo, Jose N; Hartman, Terryl J; Jones, Dean P; Ziegler, Thomas R; Alvarez, Jessica A.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Adipose Tissue/pp [Physiopathology]
+ Adult
+ Biomarkers/an [Analysis]
+ Body Composition
+ *Body Mass Index
+ *Body Weight/ph [Physiology]
+ Cardiometabolic Risk Factors
+ Cross-Sectional Studies
+ Diet Surveys
+ *Diet, Healthy/sn [Statistics & Numerical Data]
+ Diet, Mediterranean/sn [Statistics & Numerical Data]
+ Dietary Approaches To Stop Hypertension/sn [Statistics & Numerical Data]
+ Eating/ph [Physiology]
+ Exercise Test
+ Female
+ Humans
+ Ideal Body Weight
+ Linear Models
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Overweight/pp [Physiopathology]
+ Oxygen Consumption/ph [Physiology]
+ *Physical Fitness/ph [Physiology]
+Keyword Heading
+ Exercise
+ Fat distribution
+ Nutrition
+ Overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Individuals with normal weight obesity (NWO) have increased cardiometabolic disease and mortality risk, but factors contributing to NWO development are unknown.
+
+ OBJECTIVE: The objective of this study was to determine whether diet quality scores and physical fitness levels differed between adults classified as lean, NWO, and overweight-obese. Secondary objectives of the study were to compare clinical biomarkers and food groups and macronutrient intakes between the three groups, and to test for associations between body composition components with diet quality scores and physical fitness levels.
+
+ DESIGN: This is a secondary data analysis from a cross-sectional study that included metropolitan university and health care system employees. Body composition was measured by dual energy x-ray absorptiometry. Individuals with a body mass index <25 kg/m2 and body fat >23% for men and >30% for women were classified as having NWO. Alternate Healthy Eating Index, Dietary Approaches to Stop Hypertension score, and Mediterranean Diet Score were calculated from Block food frequency questionnaires. Physical fitness was assessed by measuring maximal oxygen uptake (VO2 maximum) during treadmill testing.
+
+ PARTICIPANTS/SETTING: This study included 693 adults (65% women, mean age 48.9 +/- 11.5 years) enrolled between 2007 and 2013 in Atlanta, GA.
+
+ MAIN OUTCOME MEASURES: The main outcome measures were Alternate Healthy Eating Index, Dietary Approaches to Stop Hypertension, and Mediterranean Diet Score diet quality scores and maximal oxygen uptake.
+
+ STATISTICAL ANALYSES: Multiple linear regression analyses with post hoc comparisons were used to investigate group differences in fitness, diet quality, and biomarkers. Regression analyses were also used to examine relationships between diet quality scores and fitness with body composition.
+
+ RESULTS: VO2 maximum was significantly lower in the NWO compared with the lean group (36.2 +/- 0.8 mL/min/kg vs 40.2 +/- 1.0 mL/min/kg; P < 0.05). Individuals with NWO reported similar diet quality to lean individuals and more favorable Alternate Healthy Eating Index and Dietary Approaches to Stop Hypertension scores than individuals with overweight-obesity (P < 0.05). Diet quality scores and physical fitness levels were inversely associated with percent body fat and visceral adipose tissue (P < 0.05), regardless of weight status. Individuals with NWO exhibited higher fasting blood insulin concentrations, insulin resistance, low-density lipoprotein cholesterol, and triglyceride levels, and significantly lower high-density lipoprotein cholesterol levels than lean individuals (P < 0.05).
+
+ CONCLUSIONS: Physical fitness was significantly decreased in individuals with NWO compared with lean individuals. Higher diet quality was associated with decreased total and visceral fat but did not distinguish individuals with NWO from lean individuals. Copyright © 2020 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.jand.2020.07.020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bellissimo&issn=2212-2672&title=Journal+of+the+Academy+of+Nutrition+%26+Dietetics&atitle=Physical+Fitness+but+Not+Diet+Quality+Distinguishes+Lean+and+Normal+Weight+Obese+Adults.&volume=120&issue=12&spage=1963&epage=1973.e2&date=2020&doi=10.1016%2Fj.jand.2020.07.020&pmid=33011149&sid=OVID:medline
+
+<1169>
+Unique Identifier
+ 33004937
+Title
+ Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance.
+Source
+ Scientific Reports. 10(1):16364, 2020 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kochumon S; Al Madhoun A; Al-Rashed F; Thomas R; Sindhu S; Al-Ozairi E; Al-Mulla F; Ahmad R
+Authors Full Name
+ Kochumon, Shihab; Al Madhoun, Ashraf; Al-Rashed, Fatema; Thomas, Reeby; Sindhu, Sardar; Al-Ozairi, Ebaa; Al-Mulla, Fahd; Ahmad, Rasheed.
+Institution
+ Kochumon, Shihab. Immunology and Microbiology Department, Dasman Diabetes Institute, Jasim Mohamad Al Bahar St., P.O. Box 1180, 15462, Kuwait City, Kuwait.
+ Al Madhoun, Ashraf. Animal and Imaging Core Facilities, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al Madhoun, Ashraf. Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al-Rashed, Fatema. Immunology and Microbiology Department, Dasman Diabetes Institute, Jasim Mohamad Al Bahar St., P.O. Box 1180, 15462, Kuwait City, Kuwait.
+ Al-Rashed, Fatema. Immunology Department, Ministry of Health, Kuwait City, Kuwait.
+ Thomas, Reeby. Immunology and Microbiology Department, Dasman Diabetes Institute, Jasim Mohamad Al Bahar St., P.O. Box 1180, 15462, Kuwait City, Kuwait.
+ Sindhu, Sardar. Animal and Imaging Core Facilities, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al-Ozairi, Ebaa. Medical Division, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al-Mulla, Fahd. Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Ahmad, Rasheed. Immunology and Microbiology Department, Dasman Diabetes Institute, Jasim Mohamad Al Bahar St., P.O. Box 1180, 15462, Kuwait City, Kuwait. rasheed.ahmad@dasmaninstitute.org.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Cytokines/me [Metabolism]
+ Humans
+ Inflammation/me [Metabolism]
+ Inflammation Mediators/me [Metabolism]
+ *Insulin Resistance/ph [Physiology]
+ *Interleukin-2/me [Metabolism]
+ Middle Aged
+ *Obesity/me [Metabolism]
+ *Subcutaneous Fat/me [Metabolism]
+Abstract
+ Adipose tissue (AT) associated cytokines are involved in the development of chronic low-grade inflammation in obese individuals. IL-2, a pleiotropic cytokine, contributes to immune alterations during inflammation. However, the interaction between AT-IL-2 and other inflammatory biomolecules in obesity remains elusive. We investigated whether AT-IL-2 expression was associated with markers of inflammation and insulin resistance in overweight/obese individuals. Subcutaneous fat tissues were collected from 56 individuals (lean/overweight/obese) for RNA extraction. IL-2 and inflammatory mediators were quantified by qRT-PCR and immunohistochemistry. CRP was measured by ELISA. AT-IL-2 expression was higher in obese compared with lean individuals (P < 0.021) and correlated with BMI. IL-2 correlated with interleukins IL-8 and IL-12A (r = 0.333-0.481; p = 0.0001-0.029); as well as with chemokines and their receptors including CCL5, CCL19, CCR2 and CCR5 (r = 0.538-0.677; p < 0.0001). Moreover, IL-2 correlated with toll-like receptors (TLR2, TLR8, TLR10), interferon regulatory factor 5 (IRF5) and cluster of differentiation CD11c (r = 0.282-0.357; p < 0.039). Notably, IL-2 was associated positively with fasting blood glucose (FBG), HbA1c, TGL and CRP (r >= 0.423;P <= 0.007). In multiple regression analysis, IL-2 is an independent predictor of IL-8, IL-12A, TLR10, TGL and HbA1c. Overall, our data demonstrate that increased expression of the AT-IL-2, in obesity, may represent a novel biomarker for progression of metabolic inflammation and insulin-resistance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators). 0 (Interleukin-2).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-73347-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kochumon&issn=2045-2322&title=Scientific+Reports&atitle=Elevated+adipose+tissue+associated+IL-2+expression+in+obesity+correlates+with+metabolic+inflammation+and+insulin+resistance.&volume=10&issue=1&spage=16364&epage=&date=2020&doi=10.1038%2Fs41598-020-73347-y&pmid=33004937&sid=OVID:medline
+
+<1170>
+Unique Identifier
+ 33003626
+Title
+ Increased Growth Differentiation Factor 15 in Patients with Hypoleptinemia-Associated Lipodystrophy.
+Source
+ International Journal of Molecular Sciences. 21(19), 2020 Sep 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kralisch S; Hoffmann A; Estrada-Kunz J; Stumvoll M; Fasshauer M; Tonjes A; Miehle K
+Authors Full Name
+ Kralisch, Susan; Hoffmann, Annett; Estrada-Kunz, Juliane; Stumvoll, Michael; Fasshauer, Mathias; Tonjes, Anke; Miehle, Konstanze.
+Institution
+ Kralisch, Susan. Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
+ Kralisch, Susan. IFB AdiposityDiseases, Leipzig University Medical Center, University of Leipzig, 04103 Leipzig, Germany.
+ Hoffmann, Annett. Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
+ Estrada-Kunz, Juliane. Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
+ Stumvoll, Michael. Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
+ Fasshauer, Mathias. Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
+ Fasshauer, Mathias. IFB AdiposityDiseases, Leipzig University Medical Center, University of Leipzig, 04103 Leipzig, Germany.
+ Fasshauer, Mathias. Department of Nutritional Sciences, University of Giessen, 35390 Giebetaen, Germany.
+ Tonjes, Anke. Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
+ Miehle, Konstanze. Medical Department-Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Female
+ Gene Expression Regulation/ge [Genetics]
+ Glycated Hemoglobin/me [Metabolism]
+ *Growth Differentiation Factor 15/bl [Blood]
+ Growth Differentiation Factor 15/ge [Genetics]
+ Humans
+ Insulin Resistance/ge [Genetics]
+ *Leptin/bl [Blood]
+ *Lipodystrophy/bl [Blood]
+ Lipodystrophy/ge [Genetics]
+ Lipodystrophy/pa [Pathology]
+ Male
+ Mice
+ Mice, Transgenic
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ *Sterol Regulatory Element Binding Protein 2/ge [Genetics]
+ Triglycerides/bl [Blood]
+Keyword Heading
+ GDF15
+ adipokine
+ insulin resistance
+ leptin
+ lipodystrophy
+ obesity
+ triglycerides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective. Similar to obesity, lipodystrophy (LD) causes adipose tissue dysfunction and severe metabolic complications. Growth differentiation factor 15 (GDF15) belongs to the transforming growth factor beta superfamily and is dysregulated in metabolic disease including obesity and diabetes mellitus. Circulating levels in LD and the impact of leptin treatment have not been investigated so far. Material and Methods. GDF15 serum levels were quantified in 60 LD patients without human immunodeficiency virus infection and 60 controls matched for age, gender, and body mass index. The impact of metreleptin treatment on circulating GDF15 was assessed in a subgroup of patients. GDF15 mRNA expression was determined in metabolic tissues of leptin-deficient lipodystrophic aP2-nSREBP1c-Tg mice, obese ob/ob mice, and control C57Bl6 mice. Results. Median GDF15 serum concentrations were significantly higher in LD patients (819 ng/L) as compared to the control group (415 ng/L) (p < 0.001). In multiple linear regression analysis, an independent and positive association remained between GDF15 on one hand and age, patient group, hemoglobin A1c, triglycerides, and C-reactive protein on the other hand. Moreover, there was an independent negative association between GFD15 and estimated glomerular filtration rate. Circulating GDF15 was not significantly affected by metreleptin treatment in LD patients. Gdf15 was upregulated in leptin-deficient lipodystrophic mice as compared to controls. Moreover, Gdf15 mRNA expression was downregulated by leptin treatment in lipodystrophic and obese animals. Conclusions. Serum concentrations of GDF15 are elevated in LD patients and independently associated with markers of metabolic dysfunction. Gdf15 expression is higher in lipodystrophic mice and downregulated by leptin treatment.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (GDF15 protein, human). 0 (Glycated Hemoglobin A). 0 (Growth Differentiation Factor 15). 0 (Leptin). 0 (Srebf2 protein, mouse). 0 (Sterol Regulatory Element Binding Protein 2). 0 (Triglycerides). 0 (hemoglobin A1c protein, human). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21197214
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kralisch&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Increased+Growth+Differentiation+Factor+15+in+Patients+with+Hypoleptinemia-Associated+Lipodystrophy.&volume=21&issue=19&spage=7214&epage=&date=2020&doi=10.3390%2Fijms21197214&pmid=33003626&sid=OVID:medline
+
+<1171>
+Unique Identifier
+ 33002457
+Title
+ Diagnostic and prognostic considerations for use of natriuretic peptides in obese patients with heart failure. [Review]
+Source
+ Progress in Cardiovascular Diseases. 63(5):649-655, 2020 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Singh S; Pandey A; Neeland IJ
+Authors Full Name
+ Singh, Shruti; Pandey, Ambarish; Neeland, Ian J.
+Institution
+ Singh, Shruti. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.
+ Pandey, Ambarish. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.
+ Neeland, Ian J. University Hospitals Harrington Heart and Vascular Institute and Case Western Reserve University, Cleveland, OH, United States of America. Electronic address: Ian.Neeland@UHhospitals.org.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Heart Failure/bl [Blood]
+ Heart Failure/di [Diagnosis]
+ Heart Failure/ep [Epidemiology]
+ Heart Failure/pp [Physiopathology]
+ Humans
+ *Natriuretic Peptide, Brain/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ *Peptide Fragments/bl [Blood]
+ Predictive Value of Tests
+ Prognosis
+ Stroke Volume
+ Ventricular Function, Left
+Keyword Heading
+ B-type natriuretic peptide
+ Heart failure
+ Natriuretic peptides
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Natriuretic peptides (NPs, B-type natriuretic peptide /BNP and NT-proBNP) are universally used biomarkers with established cut-points to aid in the diagnosis of heart failure (HF). It has been demonstrated that an inverse relationship exists between obesity, defined by the body mass index (BMI), and NPs, such that the application of NPs to diagnostic algorithms in HF remains challenging in overweight and obese patients. Some have advocated that lowering the cut-offs for NPs or using a correction for high BMI may improve the diagnostic accuracy in obese individuals. The inverse relationship of NPs with high BMI is present in both HF with reduced (HFrEF) and with preserved (HFpEF) ejection fraction, although levels tend to be higher in HFrEF. Nevertheless, data from several studies have shown that the prognostic value of NPs is preserved across BMI classes, and that increasing circulating levels of NPs correlate with adverse outcomes including all-cause mortality and HF hospitalizations. While NPs can still be used in diagnosis of HF in obese individuals, lower thresholds and the clinical context should be utilized in decision making. Additionally, given the validated prognostic value even in obesity, NPs can be employed in risk-stratification of individuals with obesity and HF, although there remains limited evidence about use in those with severe obesity (BMI >40 kg/m2). Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.pcad.2020.09.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Singh&issn=0033-0620&title=Progress+in+Cardiovascular+Diseases&atitle=Diagnostic+and+prognostic+considerations+for+use+of+natriuretic+peptides+in+obese+patients+with+heart+failure.&volume=63&issue=5&spage=649&epage=655&date=2020&doi=10.1016%2Fj.pcad.2020.09.006&pmid=33002457&sid=OVID:medline
+
+<1172>
+Unique Identifier
+ 33000156
+Title
+ Alterations in Sulfur Amino Acids as Biomarkers of Disease. [Review]
+Source
+ Journal of Nutrition. 150(Suppl 1):2532S-2537S, 2020 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stabler SP
+Authors Full Name
+ Stabler, Sally P.
+Institution
+ Stabler, Sally P. Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
+MeSH Subject Headings
+ Alcoholism/bl [Blood]
+ Amino Acids, Sulfur/bl [Blood]
+ *Amino Acids, Sulfur/me [Metabolism]
+ Anemia, Megaloblastic/bl [Blood]
+ Biomarkers/bl [Blood]
+ Cardiovascular Diseases/bl [Blood]
+ *Folic Acid/bl [Blood]
+ Folic Acid Deficiency/bl [Blood]
+ *Folic Acid Deficiency/co [Complications]
+ Humans
+ *Hyperhomocysteinemia/bl [Blood]
+ Hyperhomocysteinemia/co [Complications]
+ Kidney Failure, Chronic/bl [Blood]
+ Liver Diseases/bl [Blood]
+ *Nutritional Status
+ Obesity/bl [Blood]
+ S-Adenosylhomocysteine/bl [Blood]
+ *Vitamin B 12/bl [Blood]
+ Vitamin B 12 Deficiency/bl [Blood]
+ *Vitamin B 12 Deficiency/co [Complications]
+Keyword Heading
+ S-adenosylhomocysteine
+ cobalamin
+ cystathionine
+ cysteine
+ folate
+ homocysteine
+ methionine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Homocysteine (Hcy) is methylated by methionine synthase to form methionine with methyl-cobalamin as a cofactor. The reaction demethylates 5-methyltetrahydrofolate to tetrahydrofolate, which is required for DNA and RNA synthesis. Deficiency of either of the cobalamin (Cbl) and/or folate cofactors results in elevated Hcy and megaloblastic anemia. Elevated Hcy is a sensitive biomarker of Cbl and/or folate status and more specific than serum vitamin assays. Elevated Hcy normalizes when the correct vitamin is given. Elevated Hcy is associated with alcohol use disorder and drugs that target folate or Cbl metabolism, and is a risk factor for thrombotic vascular disease. Elevated methionine and cystathionine are associated with liver disease. Elevated Hcy, cystathionine, and cysteine, but not methionine, are common in patients with chronic renal failure. Higher cysteine predicts obesity and future weight gain. Serum S-adenosylhomocysteine (AdoHcy) is elevated in Cbl deficiency and chronic renal failure. Drugs that require methylation for catabolism may deplete liver S-adenosylmethionine and raise AdoHcy and Hcy. Deficiency of Cbl or folate or perturbations of their metabolism cause major changes in sulfur amino acids. Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Sulfur). 0 (Biomarkers). 935E97BOY8 (Folic Acid). 979-92-0 (S-Adenosylhomocysteine). P6YC3EG204 (Vitamin B 12).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1093%2fjn%2fnxaa118
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stabler&issn=0022-3166&title=Journal+of+Nutrition&atitle=Alterations+in+Sulfur+Amino+Acids+as+Biomarkers+of+Disease.&volume=150&issue=1&spage=2532S&epage=2537S&date=2020&doi=10.1093%2Fjn%2Fnxaa118&pmid=33000156&sid=OVID:medline
+
+<1173>
+Unique Identifier
+ 32998364
+Title
+ Effectiveness of a Very Low Calorie Ketogenic Diet on Testicular Function in Overweight/Obese Men.
+Source
+ Nutrients. 12(10), 2020 Sep 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mongioi LM; Cimino L; Condorelli RA; Magagnini MC; Barbagallo F; Cannarella R; La Vignera S; Calogero AE
+Author NameID
+ Mongioi, Laura M; ORCID: https://orcid.org/0000-0003-2341-0996
+ Cimino, Laura; ORCID: https://orcid.org/0000-0001-6444-7205
+ Condorelli, Rosita A; ORCID: https://orcid.org/0000-0002-5217-9343
+ Cannarella, Rossella; ORCID: https://orcid.org/0000-0003-4599-8487
+ La Vignera, Sandro; ORCID: https://orcid.org/0000-0002-7113-2372
+ Calogero, Aldo E; ORCID: https://orcid.org/0000-0001-6950-335X
+Authors Full Name
+ Mongioi, Laura M; Cimino, Laura; Condorelli, Rosita A; Magagnini, Maria Cristina; Barbagallo, Federica; Cannarella, Rossella; La Vignera, Sandro; Calogero, Aldo E.
+Institution
+ Mongioi, Laura M. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
+ Cimino, Laura. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
+ Condorelli, Rosita A. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
+ Magagnini, Maria Cristina. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
+ Barbagallo, Federica. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
+ Cannarella, Rossella. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
+ La Vignera, Sandro. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
+ Calogero, Aldo E. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Weight
+ *Caloric Restriction/mt [Methods]
+ *Diet, Ketogenic/mt [Methods]
+ Humans
+ *Hypogonadism/dh [Diet Therapy]
+ Hypogonadism/et [Etiology]
+ Lower Urinary Tract Symptoms/dh [Diet Therapy]
+ Lower Urinary Tract Symptoms/et [Etiology]
+ Luteinizing Hormone/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Overweight/co [Complications]
+ *Overweight/dh [Diet Therapy]
+ Overweight/pp [Physiopathology]
+ Prospective Studies
+ Prostate-Specific Antigen/bl [Blood]
+ Prostatic Diseases/et [Etiology]
+ Prostatic Diseases/pc [Prevention & Control]
+ Testicular Diseases/et [Etiology]
+ Testicular Diseases/pc [Prevention & Control]
+ Testis/pp [Physiopathology]
+ Testosterone/bl [Blood]
+ Treatment Outcome
+ Waist Circumference
+Keyword Heading
+ glucose homeostasis
+ lipid profile
+ testosterone
+ very-low-calorie ketogenic diet
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity has become an increasingly worrisome reality. A very-low-calorie ketogenic diet (VLCKD) represents a promising option by which to achieve significant weight loss. This study sought to evaluate the effectiveness of VLCKD on metabolic parameters and hormonal profiles of obese male patients.
+
+ METHODS: We enrolled 40 overweight/obese men who consumed VLCKD for at least eight weeks. Body weight, waist circumference, fasting glucose, insulin, total cholesterol, high-density lipoprotein, triglycerides, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, vitamin D, luteinizing hormone (LH), total testosterone (TT), and prostate-specific antigen (PSA) were calculated before and after VLCKD consumption. We additionally determined the homeostasis model assessment index and low-density lipoprotein (LDL) values.
+
+ RESULTS: After VLCKD (13.5 +/- 0.83 weeks), the mean body weight loss was 21.05 +/- 1.44 kg; the glucose homeostasis and lipid profile were improved significantly; serum vitamin D, LH, and TT levels were increased and the PSA levels were decreased significantly as compared with pretreatment values. These results are of interest since obesity can lead to hypogonadism and in turn, testosterone deficiency is associated with impaired glucose homeostasis, metabolic syndrome, and diabetes mellitus. Moreover, a close relationship between obesity, insulin resistance, and/or hyperinsulinemia and increased prostate volume has been reported, with a consequent greater risk of developing lower urinary tract symptoms.
+
+ CONCLUSIONS: VLCKD is an effective tool against obesity and could be a noninvasive, rapid, and valid means to treat obese patients with metabolic hypogonadism and lower urinary tract symptoms.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3XMK78S47O (Testosterone). 9002-67-9 (Luteinizing Hormone). EC 3-4-21-77 (Prostate-Specific Antigen).
+Publication Type
+ Evaluation Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12102967
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mongioi&issn=2072-6643&title=Nutrients&atitle=Effectiveness+of+a+Very+Low+Calorie+Ketogenic+Diet+on+Testicular+Function+in+Overweight%2FObese+Men.&volume=12&issue=10&spage=&epage=&date=2020&doi=10.3390%2Fnu12102967&pmid=32998364&sid=OVID:medline
+
+<1174>
+Unique Identifier
+ 32993674
+Title
+ Association between obesity-associated markers and semen quality parameters and serum reproductive hormones in Chinese infertile men.
+Source
+ Reproductive Biology & Endocrinology. 18(1):95, 2020 Sep 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ma JX; Wang B; Li HS; Jiang XJ; Yu J; Ding CF; Chen WQ
+Authors Full Name
+ Ma, Jian-Xiong; Wang, Bin; Li, Hai-Song; Jiang, Xue-Juan; Yu, Jia; Ding, Cai-Fei; Chen, Wang-Qiang.
+Institution
+ Ma, Jian-Xiong. The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
+ Ma, Jian-Xiong. Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 East HuanCheng Road, Hangzhou, 310003, China.
+ Ma, Jian-Xiong. Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100007, China.
+ Wang, Bin. Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100007, China.
+ Li, Hai-Song. Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100007, China.
+ Jiang, Xue-Juan. Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 East HuanCheng Road, Hangzhou, 310003, China.
+ Yu, Jia. Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 East HuanCheng Road, Hangzhou, 310003, China.
+ Ding, Cai-Fei. Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 East HuanCheng Road, Hangzhou, 310003, China. dingcaifei@163.com.
+ Chen, Wang-Qiang. Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 East HuanCheng Road, Hangzhou, 310003, China. reproductivedcf@sina.com.
+MeSH Subject Headings
+ Adult
+ Asian People
+ Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ China
+ Cohort Studies
+ *Gonadal Steroid Hormones/bl [Blood]
+ Humans
+ Infertility, Male/bl [Blood]
+ *Infertility, Male/et [Etiology]
+ Infertility, Male/pp [Physiopathology]
+ Leptin/bl [Blood]
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Risk Factors
+ *Semen Analysis
+ Young Adult
+Keyword Heading
+ Body mass index (BMI)
+ Semen parameters
+ Seminal leptin
+ Serum leptin
+ Serum reproductive hormones
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The current evidence on the association between obesity-associated markers and semen quality, serum reproductive hormones and lipids remains inconsistent. In this study, we tested the hypothesis that, in infertile Chinese men, body mass index (BMI) negatively correlates with sperm concentration, serum total testosterone (TT), and high-density lipoprotein cholesterol (HDL-C). The relationship between other obesity-associated markers and semen quality parameters, serum reproductive hormones, lipids and leptin were also investigated.
+
+ METHODS: 181 Chinese infertile men were recruited from September 2018 to September 2019. Their obesity-associated markers, semen parameters, and serum reproductive hormones, lipids and leptin were detected. Statistical analysis was performed to assess the relationship between obesity-associated markers and semen quality, serum reproductive hormones, lipids and leptin.
+
+ RESULT(S): Statistically negative correlation was found between other obesity-associated markers (e.g. waist-to-hip ratio and waist-to-height ratio) and semen parameters (e.g. sperm concentration, ratio of progressive motility and ratio of non-progressive motility), while no significant correlation was found between BMI and semen quality, serum reproductive hormones, lipids and leptin. Ratio of morphologically normal sperm was negatively correlated with serum lipids including total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), leptin and seminal superoxide dismutase. Ratio of progressive sperm, sperm concentration and ratio of morphologically normal sperm exhibited significantly lower values in overweight group than normal group. Estradiol (E2) and E2/TT were significantly higher in obese group than normal group, while TT level was significantly lower in obese group than normal group. Univariate and multivariate analysis indicated that TC was significantly associated with BMI. Serum leptin concentration was positively correlated with seminal leptin concentration in overweight and obese groups.
+
+ CONCLUSION(S): No significant correlation was found between BMI and sperm concentration, serum TT and HDL-C, while other obesity-associated markers were found to negatively correlate with sperm concentration, ratio of progressive motility and ratio of non-progressive motility. Statistically significant correlations between serum reproductive hormones, lipids and leptin also existed in Chinese infertile men.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Gonadal Steroid Hormones). 0 (Leptin). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12958-020-00652-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ma&issn=1477-7827&title=Reproductive+Biology+%26+Endocrinology&atitle=Association+between+obesity-associated+markers+and+semen+quality+parameters+and+serum+reproductive+hormones+in+Chinese+infertile+men.&volume=18&issue=1&spage=95&epage=&date=2020&doi=10.1186%2Fs12958-020-00652-6&pmid=32993674&sid=OVID:medline
+
+<1175>
+Unique Identifier
+ 32991385
+Title
+ A Case Illustrating the Practical Application of the AAOS Clinical Practice Guideline: Diagnosis and Prevention of Periprosthetic Joint Infection.
+Source
+ Journal of the American Academy of Orthopaedic Surgeons. 28(24):e1081-e1085, 2020 Dec 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen AF; Riedel S
+Author NameID
+ Chen, Antonia F; ORCID: https://orcid.org/0000-0003-2040-8188
+ Riedel, Stefan; ORCID: https://orcid.org/0000-0002-0573-4957
+Authors Full Name
+ Chen, Antonia F; Riedel, Stefan.
+Institution
+ Chen, Antonia F. From the Department of Orthopaedic Surgery, Brigham and Women's Hospital (Dr. Chen), Division of Adult Reconstruction and Total Joint Arthroplasty, Department of Orthopaedic Surgery, Harvard Medical School (Dr. Chen), Clinical Microbiology Laboratories, Department of Pathology, Beth Israel Deaconess Medical Center (Dr. Riedel), and Department of Pathology, Harvard Medical School (Dr. Riedel), Boston, MA.
+MeSH Subject Headings
+ Aged
+ Anti-Bacterial Agents/ad [Administration & Dosage]
+ *Arthroplasty, Replacement, Knee/ae [Adverse Effects]
+ Biomarkers/bl [Blood]
+ Ceftazidime/ad [Administration & Dosage]
+ Ciprofloxacin/ad [Administration & Dosage]
+ Clinical Laboratory Techniques
+ Humans
+ Injections, Intra-Articular/ae [Adverse Effects]
+ *Knee Joint
+ Male
+ Obesity
+ Orthopedic Procedures/mt [Methods]
+ Positron Emission Tomography Computed Tomography
+ Postoperative Care
+ *Practice Guidelines as Topic
+ *Prosthesis-Related Infections/di [Diagnosis]
+ Prosthesis-Related Infections/et [Etiology]
+ *Prosthesis-Related Infections/pc [Prevention & Control]
+ Prosthesis-Related Infections/th [Therapy]
+ Risk Factors
+ Treatment Outcome
+Abstract
+ The American Academy of Orthopaedic Surgeons Clinical Practice Guideline "Diagnosis and Prevention of Periprosthetic Joint Infections (PJI)" is a summary of the available literature designed to help guide surgeons and other qualified physicians in the management of PJI. Obesity and intra-articular joint injections are associated with an increased risk of PJI according to this Clinical Practice Guideline. Serum erythrocyte sedimentation rate, C-reactive protein, and/or interleukin-6 should be obtained when diagnosing PJI. Synovial fluid leukocyte count, neutrophil percentage, aerobic and anaerobic bacterial cultures, leukocyte esterase, alpha-defensin, C-reactive protein, and nucleic acid amplification testing may assist with the diagnosis of PJI. Antibiotics should be held for 2 weeks before obtaining samples. Intraoperatively, Gram stains do not help with PJI diagnosis, whereas histopathology samples are helpful. These guidelines may help clinicians with the prevention and diagnosis of PJI.
+Registry Number/Name of Substance
+ 0 (Anti-Bacterial Agents). 0 (Biomarkers). 5E8K9I0O4U (Ciprofloxacin). 9M416Z9QNR (Ceftazidime).
+Publication Type
+ Case Reports. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.5435%2fJAAOS-D-20-00438
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1067-151X&title=Journal+of+the+American+Academy+of+Orthopaedic+Surgeons&atitle=A+Case+Illustrating+the+Practical+Application+of+the+AAOS+Clinical+Practice+Guideline%3A+Diagnosis+and+Prevention+of+Periprosthetic+Joint+Infection.&volume=28&issue=24&spage=e1081&epage=e1085&date=2020&doi=10.5435%2FJAAOS-D-20-00438&pmid=32991385&sid=OVID:medline
+
+<1176>
+Unique Identifier
+ 32989109
+Title
+ Association of midlife vascular risk and AD biomarkers with subsequent cognitive decline.
+Source
+ Neurology. 95(23):e3093-e3103, 2020 12 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pettigrew C; Soldan A; Wang J; Wang MC; Arthur K; Moghekar A; Gottesman RF; Albert M
+Author NameID
+ Pettigrew, Corinne; ORCID: https://orcid.org/0000-0003-4264-275X
+ Soldan, Anja; ORCID: https://orcid.org/0000-0002-6193-0418
+ Moghekar, Abhay; ORCID: https://orcid.org/0000-0001-9464-1551
+Authors Full Name
+ Pettigrew, Corinne; Soldan, Anja; Wang, Jiangxia; Wang, Mei-Cheng; Arthur, Karissa; Moghekar, Abhay; Gottesman, Rebecca F; Albert, Marilyn.
+Institution
+ Pettigrew, Corinne. From the Department of Neurology (C.P., A.S., K.A., A.M., R.F.G., M.A.), The Johns Hopkins University School of Medicine; and Department of Biostatistics (J.W., M.-C.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. cpettigrew@jhmi.edu.
+ Soldan, Anja. From the Department of Neurology (C.P., A.S., K.A., A.M., R.F.G., M.A.), The Johns Hopkins University School of Medicine; and Department of Biostatistics (J.W., M.-C.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
+ Wang, Jiangxia. From the Department of Neurology (C.P., A.S., K.A., A.M., R.F.G., M.A.), The Johns Hopkins University School of Medicine; and Department of Biostatistics (J.W., M.-C.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
+ Wang, Mei-Cheng. From the Department of Neurology (C.P., A.S., K.A., A.M., R.F.G., M.A.), The Johns Hopkins University School of Medicine; and Department of Biostatistics (J.W., M.-C.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
+ Arthur, Karissa. From the Department of Neurology (C.P., A.S., K.A., A.M., R.F.G., M.A.), The Johns Hopkins University School of Medicine; and Department of Biostatistics (J.W., M.-C.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
+ Moghekar, Abhay. From the Department of Neurology (C.P., A.S., K.A., A.M., R.F.G., M.A.), The Johns Hopkins University School of Medicine; and Department of Biostatistics (J.W., M.-C.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
+ Gottesman, Rebecca F. From the Department of Neurology (C.P., A.S., K.A., A.M., R.F.G., M.A.), The Johns Hopkins University School of Medicine; and Department of Biostatistics (J.W., M.-C.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
+ Albert, Marilyn. From the Department of Neurology (C.P., A.S., K.A., A.M., R.F.G., M.A.), The Johns Hopkins University School of Medicine; and Department of Biostatistics (J.W., M.-C.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Alzheimer Disease/cf [Cerebrospinal Fluid]
+ Alzheimer Disease/ep [Epidemiology]
+ Alzheimer Disease/pp [Physiopathology]
+ *Alzheimer Disease
+ *Amyloid beta-Peptides/cf [Cerebrospinal Fluid]
+ Biomarkers/cf [Cerebrospinal Fluid]
+ Cardiovascular Diseases/cf [Cerebrospinal Fluid]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/pp [Physiopathology]
+ *Cardiovascular Diseases
+ Cognitive Dysfunction/cf [Cerebrospinal Fluid]
+ Cognitive Dysfunction/ep [Epidemiology]
+ Cognitive Dysfunction/pp [Physiopathology]
+ *Cognitive Dysfunction
+ Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ Hypercholesterolemia/ep [Epidemiology]
+ Hypertension/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ *Peptide Fragments/cf [Cerebrospinal Fluid]
+ Risk Factors
+ Smoking/ep [Epidemiology]
+ *tau Proteins/cf [Cerebrospinal Fluid]
+Abstract
+ OBJECTIVE: To determine whether vascular risk and Alzheimer disease (AD) biomarkers have independent or synergistic effects on cognitive decline and whether vascular risk is associated with the accumulation of AD pathology as measured by change in biomarkers over time.
+
+ METHODS: At baseline, participants (n = 168) were cognitively normal and primarily middle-aged (mean 56.4 years, SD 10.9 years) and had both vascular risk factor status and proximal CSF biomarkers available. Baseline vascular risk was quantified with a composite vascular risk score reflecting the presence or absence of hypertension, hypercholesterolemia, diabetes, current smoking, and obesity. CSF biomarkers of beta-amyloid (Abeta)1-42, total tau (t-tau), and phosphorylated tau (p-tau) were used to create dichotomous high and low AD biomarker groups (based on Abeta1-42 and tau). Linear mixed-effects models were used to examine change in a cognitive composite score (mean follow-up 13.9 years) and change in CSF biomarkers (mean follow-up 4.2 years).
+
+ RESULTS: There was no evidence of a synergistic relationship between the vascular risk score and CSF AD biomarkers and cognitive decline. Instead, the vascular risk score (estimate -0.022, 95% confidence interval [CI] -0.043 to -0.002, p = 0.03) and AD biomarkers (estimate -0.060, 95% CI -0.096 to -0.024, p = 0.001) were independently and additively associated with cognitive decline. In addition, the vascular risk score was unrelated to levels of or rate of change in CSF Abeta1-42, t-tau, or p-tau.
+
+ CONCLUSIONS: The results of this observational cohort study suggest that vascular risk and biomarkers of AD pathology, when measured in midlife, act along independent pathways and underscore the importance of accounting for multiple risk factors for identifying cognitively normal individuals at the greatest risk of cognitive decline. Copyright © 2020 American Academy of Neurology.
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Peptides). 0 (Biomarkers). 0 (MAPT protein, human). 0 (Peptide Fragments). 0 (amyloid beta-protein (1-42)). 0 (tau Proteins).
+Publication Type
+ Journal Article. Observational Study. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1212%2fWNL.0000000000010946
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pettigrew&issn=0028-3878&title=Neurology&atitle=Association+of+midlife+vascular+risk+and+AD+biomarkers+with+subsequent+cognitive+decline.&volume=95&issue=23&spage=e3093&epage=e3103&date=2020&doi=10.1212%2FWNL.0000000000010946&pmid=32989109&sid=OVID:medline
+
+<1177>
+Unique Identifier
+ 32988370
+Title
+ Association between circulating microRNAs 486, 146b and 15b and serum betatrophin levels in obese; type 2 diabetic and non-diabetic children.
+Source
+ BMC Endocrine Disorders. 20(1):145, 2020 Sep 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mohany KM; Al Rugaie O; Al-Wutayd O; Al-Nafeesah A; Saleem TH
+Authors Full Name
+ Mohany, Khalid M; Al Rugaie, Osamah; Al-Wutayd, Osama; Al-Nafeesah, Abdullah; Saleem, Tahia H.
+Institution
+ Mohany, Khalid M. Department of medical biochemistry, College of Medicine, Assiut University, Assiut, Egypt. khalidmohany9@gmail.com.
+ Mohany, Khalid M. Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia. khalidmohany9@gmail.com.
+ Al Rugaie, Osamah. Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
+ Al-Wutayd, Osama. Department of Family and Community Medicine, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
+ Al-Nafeesah, Abdullah. Department of Pediatrics, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
+ Saleem, Tahia H. Department of medical biochemistry, College of Medicine, Assiut University, Assiut, Egypt.
+MeSH Subject Headings
+ Adolescent
+ Angiopoietin-Like Protein 8
+ *Angiopoietin-like Proteins/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ Child
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Gene Expression Regulation
+ Humans
+ Insulin Resistance
+ Male
+ MicroRNAs/bl [Blood]
+ *MicroRNAs/ge [Genetics]
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ *Obesity/pa [Pathology]
+ *Peptide Hormones/bl [Blood]
+ Prognosis
+Keyword Heading
+ Betatrophin
+ Childhood obesity
+ T2DM
+ microRNA-146b and microRNA-15b
+ microRNA-486
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: This study tested the association between serum levels of microRNA-486, -146b and -15b and betatrophin in normal and obese children with/without type 2 diabetes mellitus (T2DM).
+
+ METHODS: the study included 120 children; divided into three groups: G1 (50 healthy), G2 (35 obese) and G3 (35 obese with T2DM). The levels of microRNA-486, 146b and 15b and serum betatrophin were measured by their corresponding methods.
+
+ RESULTS: serum microRNA-486, -146b, -15b and betatrophin levels were significantly high in G3 followed by G2 then G1 (p = 0.002, > 0.001, > 0.001, and > 0.001, respectively). Especially in G3, these levels correlated positively with the BMI percentile (r = 0.44, 0.58, 0.38, and 0.46, p = 0.007, > 0.001, 0.021, and 0.005, respectively), serum glucose (r = 0.56, 0.49, 0.82, 0.60, and 0.42, p > 0.001, 0.003, > 0.001, and > 0.001, respectively) and HbA1c% (r = 0.56, 0.39, 0.66, and 0.42, p > 0.001, 0.019, > 0.001, and 0.032, respectively) while, showed negative correlations with correlated with serum insulin levels (r = - 0.37, - 0.42, - 0.58, and - 0.41, p = 0.021, 0.012, > 0.001 and 0.013, respectively) and with serum C-peptide levels (r = - 0.76, - 0.50, - 0.35 and - 0.42, p > 0.001, 0.002, 0.036 and 0.011, respectively). Serum betatrophin levels correlated positively with microRNA-486, -146b and -15b levels in G2 (r = 0.35, 0.80, and 0.67, p = 0.036, > 0.001, and,> 0.001, respectively), and in G3 (r = 0.57, 0.36, and 0.38, p > 0.001, 0.029 and, 0.023, respectively).
+
+ CONCLUSIONS: Circulating microRNA-486, 146b and 15b increase significantly in obese children with T2DM and these levels correlate positively with serum betatrophin levels. Further studies are required to test the role of targeting of these microRNAs and betatrophin in the timely management of obesity and/or T2DM in children.
+Registry Number/Name of Substance
+ 0 (ANGPTL8 protein, human). 0 (Angiopoietin-Like Protein 8). 0 (Angiopoietin-like Proteins). 0 (Biomarkers). 0 (Blood Glucose). 0 (MIRN146 microRNA, human). 0 (MIRN15 microRNA, human). 0 (MIRN486 microRNA, human). 0 (MicroRNAs). 0 (Peptide Hormones).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12902-020-00628-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mohany&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Association+between+circulating+microRNAs+486%2C+146b+and+15b+and+serum+betatrophin+levels+in+obese%3B+type+2+diabetic+and+non-diabetic+children.&volume=20&issue=1&spage=145&epage=&date=2020&doi=10.1186%2Fs12902-020-00628-y&pmid=32988370&sid=OVID:medline
+
+<1178>
+Unique Identifier
+ 32987923
+Title
+ Rhubarb Supplementation Prevents Diet-Induced Obesity and Diabetes in Association with Increased Akkermansia muciniphila in Mice.
+Source
+ Nutrients. 12(10), 2020 Sep 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Regnier M; Rastelli M; Morissette A; Suriano F; Le Roy T; Pilon G; Delzenne NM; Marette A; Van Hul M; Cani PD
+Author NameID
+ Regnier, Marion; ORCID: https://orcid.org/0000-0002-5005-0597
+ Rastelli, Marialetizia; ORCID: https://orcid.org/0000-0002-4499-978X
+ Le Roy, Tiphaine; ORCID: https://orcid.org/0000-0002-0874-1490
+ Delzenne, Nathalie M; ORCID: https://orcid.org/0000-0003-2115-6082
+ Cani, Patrice D; ORCID: https://orcid.org/0000-0003-2040-2448
+Authors Full Name
+ Regnier, Marion; Rastelli, Marialetizia; Morissette, Arianne; Suriano, Francesco; Le Roy, Tiphaine; Pilon, Genevieve; Delzenne, Nathalie M; Marette, Andre; Van Hul, Matthias; Cani, Patrice D.
+Institution
+ Regnier, Marion. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Universite catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Bruxelles, Belgium.
+ Rastelli, Marialetizia. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Universite catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Bruxelles, Belgium.
+ Morissette, Arianne. Department of Medicine, Faculty of Medicine, Cardiology Axis of the Quebec Heart and Lung Institute, Quebec, QC G1V 4G5, Canada.
+ Suriano, Francesco. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Universite catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Bruxelles, Belgium.
+ Le Roy, Tiphaine. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Universite catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Bruxelles, Belgium.
+ Pilon, Genevieve. Department of Medicine, Faculty of Medicine, Cardiology Axis of the Quebec Heart and Lung Institute, Quebec, QC G1V 4G5, Canada.
+ Delzenne, Nathalie M. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Universite catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Bruxelles, Belgium.
+ Marette, Andre. Department of Medicine, Faculty of Medicine, Cardiology Axis of the Quebec Heart and Lung Institute, Quebec, QC G1V 4G5, Canada.
+ Van Hul, Matthias. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Universite catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Bruxelles, Belgium.
+ Cani, Patrice D. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Universite catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Bruxelles, Belgium.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Akkermansia/ip [Isolation & Purification]
+ *Akkermansia/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ DNA, Bacterial/ge [Genetics]
+ DNA, Bacterial/ip [Isolation & Purification]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Dietary Supplements
+ Gastrointestinal Microbiome/de [Drug Effects]
+ Glucose Tolerance Test
+ Inflammation/dt [Drug Therapy]
+ Inflammation/et [Etiology]
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ *Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ Plant Extracts/an [Analysis]
+ Plant Extracts/pd [Pharmacology]
+ Plant Roots/ch [Chemistry]
+ *Rheum/ch [Chemistry]
+ Sequence Analysis, DNA
+ Triglycerides/me [Metabolism]
+Keyword Heading
+ Akkermansia muciniphila
+ Reg3gamma
+ Rhubarb
+ diabetes
+ gut microbiota
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and obesity-related disorders, such as type 2 diabetes have been progressively increasing worldwide and treatments have failed to counteract their progression. Growing evidence have demonstrated that gut microbiota is associated with the incidence of these pathologies. Hence, the identification of new nutritional compounds, able to improve health through a modulation of gut microbiota, is gaining interest. In this context, the aim of this study was to investigate the gut-driving effects of rhubarb extract in a context of diet-induced obesity and diabetes. Eight weeks old C57BL6/J male mice were fed a control diet (CTRL), a high fat and high sucrose diet (HFHS) or a HFHS diet supplemented with 0.3% (g/g) of rhubarb extract for eight weeks. Rhubarb supplementation fully prevented HFHS-induced obesity, diabetes, visceral adiposity, adipose tissue inflammation and liver triglyceride accumulation, without any modification in food intake. By combining sequencing and qPCR methods, we found that all these effects were associated with a blooming of Akkermansia muciniphila, which is strongly correlated with increased expression of Reg3gamma in the colon. Our data showed that rhubarb supplementation is sufficient to protect against metabolic disorders induced by a diet rich in lipid and carbohydrates in association with a reciprocal interaction between Akkermansia muciniphila and Reg3gamma.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (DNA, Bacterial). 0 (Plant Extracts). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12102932
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Regnier&issn=2072-6643&title=Nutrients&atitle=Rhubarb+Supplementation+Prevents+Diet-Induced+Obesity+and+Diabetes+in+Association+with+Increased+Akkermansia+muciniphila+in+Mice.&volume=12&issue=10&spage=&epage=&date=2020&doi=10.3390%2Fnu12102932&pmid=32987923&sid=OVID:medline
+
+<1179>
+Unique Identifier
+ 32983154
+Title
+ Obesity Accelerates Age Defects in Mouse and Human B Cells. [Review]
+Source
+ Frontiers in Immunology. 11:2060, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Frasca D; Blomberg BB
+Authors Full Name
+ Frasca, Daniela; Blomberg, Bonnie B.
+Institution
+ Frasca, Daniela. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Frasca, Daniela. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Blomberg, Bonnie B. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
+ Blomberg, Bonnie B. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States.
+MeSH Subject Headings
+ Adipose Tissue/im [Immunology]
+ Adipose Tissue/me [Metabolism]
+ *Aging/im [Immunology]
+ *Aging/me [Metabolism]
+ Animals
+ Antibody Formation/im [Immunology]
+ *B-Lymphocytes/im [Immunology]
+ *B-Lymphocytes/me [Metabolism]
+ Biomarkers
+ Cytokines/me [Metabolism]
+ Disease Susceptibility
+ Humans
+ Inflammation Mediators/me [Metabolism]
+ Mice
+ *Obesity/im [Immunology]
+ *Obesity/me [Metabolism]
+Keyword Heading
+ B cells
+ aging
+ antibody responses
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity, similar to aging, is associated with chronic low-grade systemic inflammation, known as inflammaging, and represents a significantly higher risk for developing chronic diseases typical of old age. Immune cells are recruited to the obese adipose tissue (AT) by chemotactic molecules secreted by non-immune and immune cells in the AT, both contributing to the release of several pro-inflammatory mediators that fuel local and systemic inflammation, to the refractory response of immune cells to further in vivo and in vitro stimulation and to the induction of autoimmune B cells with potentially pathogenic repertoires. In terms of molecular mechanisms involved, leptin, an adipokine secreted primarily by adipocytes, has been proposed to be involved in the reduced generation of protective antibodies, and in the increased generation of autoimmune antibodies, further supporting the concept that obesity accelerates age defects. Leptin has also been shown to induce intrinsic B cell inflammation and B cell immunosenescence. The results presented in this review highlight the importance of weight reduction programs to improve immunity and reduce the risk for developing chronic diseases in obese and older individuals. Copyright © 2020 Frasca and Blomberg.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffimmu.2020.02060
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Frasca&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Obesity+Accelerates+Age+Defects+in+Mouse+and+Human+B+Cells.&volume=11&issue=&spage=2060&epage=&date=2020&doi=10.3389%2Ffimmu.2020.02060&pmid=32983154&sid=OVID:medline
+
+<1180>
+Unique Identifier
+ 32977086
+Title
+ Trend in the clinical profile of type 2 diabetes in India - Study from a diabetes care centre in South India.
+Source
+ Diabetes & Metabolic Syndrome. 14(6):1851-1857, 2020 Nov-Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nair DR; Satheesh K; Raghavan A; Nanditha A; Vinitha R; Susairaj P; Snehalatha C; Ramachandran A
+Authors Full Name
+ Nair, Dhruv Rajesh; Satheesh, Krishnamoorthy; Raghavan, Arun; Nanditha, Arun; Vinitha, Ramachandran; Susairaj, Priscilla; Snehalatha, Chamukuttan; Ramachandran, Ambady.
+Institution
+ Nair, Dhruv Rajesh. India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India.
+ Satheesh, Krishnamoorthy. India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India.
+ Raghavan, Arun. India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India.
+ Nanditha, Arun. India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India.
+ Vinitha, Ramachandran. India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India.
+ Susairaj, Priscilla. India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India.
+ Snehalatha, Chamukuttan. India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India.
+ Ramachandran, Ambady. India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India. Electronic address: dr.ramachandran@ardiabetes.org.
+MeSH Subject Headings
+ Adult
+ Aged
+ Angiotensin Receptor Antagonists/tu [Therapeutic Use]
+ Angiotensin-Converting Enzyme Inhibitors/tu [Therapeutic Use]
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Calcium Channel Blockers/tu [Therapeutic Use]
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Dyslipidemias/dt [Drug Therapy]
+ *Dyslipidemias/ep [Epidemiology]
+ Dyslipidemias/et [Etiology]
+ Dyslipidemias/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Hypertension/dt [Drug Therapy]
+ *Hypertension/ep [Epidemiology]
+ Hypertension/et [Etiology]
+ Hypertension/pa [Pathology]
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ India/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Patient Care/td [Trends]
+ Prevalence
+ Prognosis
+ Retrospective Studies
+ Risk Factors
+Keyword Heading
+ Clinical profile of type 2 diabetes
+ Comorbidities in diabetes
+ Diabetes in India
+ Diabetes management
+ Glycosylated haemoglobin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: Study the changing clinical and therapeutic profiles of type 2 diabetes (T2D) patients during a 10-year period in a diabetes care centre in Southern India.
+
+ METHODS: Retrospective, cross-sectional data of newly registered and review patients at four periods between 2009 and 2018 were analysed (n = 50,322). Clinical findings, anthropometry, blood pressure (BP), glycaemia, lipids, treatment, and co-morbid conditions were analysed. We studied the trends in age and gender distributions, body mass index (BMI), glycaemia, (Glycosylated haemoglobin A1c (HbA1c) levels), BP, cholesterol, triglycerides and therapeutic regimen during this period. Trend analyses were done.
+
+ RESULTS: Approximately 60% of patients were men. Percentages in 30-40 years increased, ~60% were aged 50-69 years and proportion of older patients decreased (p < 0.0001). In 10 years, 85.9% was overweight, obesity increased from 22.1% to 25.0% (p < 0.0001) and <13% maintained normal BMI. HbA1c <7.0% remained approximately at 22%, percentage with moderate glycaemic control (HbA1c 7.0-7.9%) increased significantly, HbA1c of >=9.0% decreased from 35.1% to 29.1% (p < 0.0001). Use of monotherapy decreased. Prevalence of hypertension increased from 16.2% to 21.6% (p < 0.0001); use of Angiotensin Receptor Blockers (ARB) and calcium channel blockers increased, Angiotensin Converting Enzyme Inhibitors and thiazides decreased (p < 0.0001). Increased use of statins paralleled with reduction in total cholesterol and LDLc.
+
+ CONCLUSION: Increasing percentages of younger patients and obesity, use of multiple drugs and reduction in HbA1c were the important observations. Rising prevalence of hypertension, increased use of ARB and statins with better control of dyslipidaemia was observed. Achievement of ideal HbA1c and BP were suboptimal. Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Angiotensin Receptor Antagonists). 0 (Angiotensin-Converting Enzyme Inhibitors). 0 (Biomarkers). 0 (Blood Glucose). 0 (Calcium Channel Blockers). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.dsx.2020.09.018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nair&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Trend+in+the+clinical+profile+of+type+2+diabetes+in+India+-+Study+from+a+diabetes+care+centre+in+South+India.&volume=14&issue=6&spage=1851&epage=1857&date=2020&doi=10.1016%2Fj.dsx.2020.09.018&pmid=32977086&sid=OVID:medline
+
+<1181>
+Unique Identifier
+ 32977024
+Title
+ The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
+Source
+ Pharmacological Research. 161:105208, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wilson RB; Chen YJ; Sutherland BG; Sawyez CG; Zhang R; Woolnough T; Hetherington AM; Peters KM; Patel K; Kennelly JP; Leonard KA; Schuurman M; Jacobs RL; Wang R; Borradaile NM
+Authors Full Name
+ Wilson, Rachel B; Chen, Yun Jin; Sutherland, Brian G; Sawyez, Cynthia G; Zhang, Richard; Woolnough, Taylor; Hetherington, Alexandra M; Peters, Kia M; Patel, Krisha; Kennelly, John P; Leonard, Kelly-Ann; Schuurman, Meg; Jacobs, Rene L; Wang, Rennian; Borradaile, Nica M.
+Institution
+ Wilson, Rachel B. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Chen, Yun Jin. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Sutherland, Brian G. Robarts Research Institute, Western University, London, ON, Canada.
+ Sawyez, Cynthia G. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Zhang, Richard. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Woolnough, Taylor. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Hetherington, Alexandra M. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Peters, Kia M. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Patel, Krisha. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Kennelly, John P. Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutrition Science, University of Alberta, Edmonton, AB, Canada.
+ Leonard, Kelly-Ann. Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutrition Science, University of Alberta, Edmonton, AB, Canada.
+ Schuurman, Meg. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Jacobs, Rene L. Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutrition Science, University of Alberta, Edmonton, AB, Canada.
+ Wang, Rennian. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
+ Borradaile, Nica M. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Electronic address: nica.borradaile@schulich.uwo.ca.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ Cell Proliferation/de [Drug Effects]
+ *Depsipeptides/pd [Pharmacology]
+ *Diet, Western
+ Disease Models, Animal
+ Endoplasmic Reticulum Stress/de [Drug Effects]
+ Energy Metabolism/de [Drug Effects]
+ Hep G2 Cells
+ Hepatic Stellate Cells/de [Drug Effects]
+ Hepatic Stellate Cells/me [Metabolism]
+ Hepatic Stellate Cells/pa [Pathology]
+ Hepatocytes/de [Drug Effects]
+ Hepatocytes/me [Metabolism]
+ Hepatocytes/pa [Pathology]
+ Humans
+ Inflammation Mediators/me [Metabolism]
+ *Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Liver Cirrhosis/et [Etiology]
+ Liver Cirrhosis/me [Metabolism]
+ Liver Cirrhosis/pa [Pathology]
+ *Liver Cirrhosis/pc [Prevention & Control]
+ Macrophages/de [Drug Effects]
+ Macrophages/me [Metabolism]
+ Male
+ Mice, 129 Strain
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease/pc [Prevention & Control]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Peptide Elongation Factor 1/ai [Antagonists & Inhibitors]
+ Peptide Elongation Factor 1/me [Metabolism]
+ *Protein Synthesis Inhibitors/pd [Pharmacology]
+ Signal Transduction
+ THP-1 Cells
+ Triglycerides/bl [Blood]
+Keyword Heading
+ Cell stress
+ EEF1A1
+ Hepatic steatosis
+ Lipotoxicity
+ Liver fibrosis
+ Liver inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Inhibition of eukaryotic elongation factor 1A1 (EEF1A1) with the marine compound didemnin B decreases lipotoxic HepG2 cell death in vitro and improves early stage non-alcoholic fatty liver disease (NAFLD) in young genetically obese mice. However, the effects of didemnin B on NAFLD in a model of long-term diet-induced obesity are not known. We investigated the effects of didemnin B on NAFLD severity and metabolic parameters in western diet-induced obese mice, and on the cell types that contribute to liver inflammation and fibrosis in vitro. Male 129S6 mice were fed either standard chow or western diet for 26 weeks, followed by intervention with didemnin B (50 mug/kg) or vehicle by intraperitoneal (i.p.) injection once every 3 days for 14 days. Didemnin B decreased liver and plasma triglycerides, improved oral glucose tolerance, and decreased NAFLD severity. Moreover, didemnin B moderately increased hepatic expression of genes involved in ER stress response (Perk, Chop), and fatty acid oxidation (Fgf21, Cpt1a). In vitro, didemnin B decreased THP-1 monocyte proliferation, disrupted THP-1 monocyte-macrophage differentiation, decreased THP-1 macrophage IL-1beta secretion, and decreased hepatic stellate cell (HSteC) proliferation and collagen secretion under both basal and lipotoxic (high fatty acid) conditions. Thus, didemnin B improves hepatic steatosis, glucose tolerance, and blood lipids in obesity, in association with moderate, possibly hormetic, upregulation of pathways involved in cell stress response and energy balance in the liver. Furthermore, it decreases the activity of the cell types implicated in liver inflammation and fibrosis in vitro. These findings highlight the therapeutic potential of partial protein synthesis inhibition in the treatment of NAFLD. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Depsipeptides). 0 (EEF1A1 protein, human). 0 (Eef1a1 protein, mouse). 0 (Inflammation Mediators). 0 (Peptide Elongation Factor 1). 0 (Protein Synthesis Inhibitors). 0 (Triglycerides). 4LSZ9C5HOB (didemnins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.phrs.2020.105208
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wilson&issn=1043-6618&title=Pharmacological+Research&atitle=The+marine+compound+and+elongation+factor+1A1+inhibitor%2C+didemnin+B%2C+provides+benefit+in+western+diet-induced+non-alcoholic+fatty+liver+disease.&volume=161&issue=&spage=105208&epage=&date=2020&doi=10.1016%2Fj.phrs.2020.105208&pmid=32977024&sid=OVID:medline
+
+<1182>
+Unique Identifier
+ 32973801
+Title
+ Role for Retinoic Acid-Related Orphan Receptor Alpha (RORalpha) Expressing Macrophages in Diet-Induced Obesity.
+Source
+ Frontiers in Immunology. 11:1966, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hams E; Roberts J; Bermingham R; Hogan AE; O'Shea D; O'Neill L; Fallon PG
+Authors Full Name
+ Hams, Emily; Roberts, Joseph; Bermingham, Rachel; Hogan, Andrew E; O'Shea, Donal; O'Neill, Luke; Fallon, Padraic G.
+Institution
+ Hams, Emily. School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
+ Roberts, Joseph. School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
+ Bermingham, Rachel. School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
+ Hogan, Andrew E. Department of Biology, National University of Ireland, Maynooth, Ireland.
+ O'Shea, Donal. Obesity Immunology Research, St. Vincent's University Hospital and University College Dublin, Dublin, Ireland.
+ O'Neill, Luke. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
+ Fallon, Padraic G. School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ *Diet
+ Diet, High-Fat
+ Disease Models, Animal
+ Energy Metabolism
+ Flow Cytometry
+ *Gene Expression
+ Humans
+ *Macrophages/me [Metabolism]
+ Mice
+ Mice, Transgenic
+ Monocytes/im [Immunology]
+ Monocytes/me [Metabolism]
+ Myeloid Cells/im [Immunology]
+ Myeloid Cells/me [Metabolism]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ *Retinoic Acid Receptor alpha/ge [Genetics]
+ Retinoic Acid Receptor alpha/me [Metabolism]
+ Stress, Physiological
+ Stromal Cells/me [Metabolism]
+Keyword Heading
+ RORalpha
+ inflammation
+ macrophage
+ metabolism
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The transcription factor RORalpha plays an important role in regulating circadian rhythm, inflammation, metabolism, and cellular development. Herein we show a role for RORalpha-expressing macrophages in the adipose tissue in altering the metabolic state of mice on a high-fat diet. The expression of Rora and RORA is elevated in white adipose tissue from obese mice and humans when compared to lean counterparts. When fed a high-fat diet Rora reporter mice revealed increased expression of Rora-YFP in macrophages in white adipose tissue deposits. To further define the potential role for Rora-expressing macrophages in the generation of an aberrant metabolic state Rorafl/flLysMCre/+ mice, which do not express Rora in myeloid cells, were maintained on a high-fat diet, and metabolic parameters assessed. These mice had significantly impaired weight gain and improved metabolic parameters in comparison to Rorafl/fl control mice. Further analysis of the immune cell populations within white adipose tissue deposits demonstrates a decrease in inflammatory adipose tissue macrophages (ATM). In obese reporter mouse there was increased in Rora-YFP expressing ATM in adipose tissue. Analysis of peritoneal macrophage populations demonstrates that within the peritoneal cavity Rora-expression is limited to myeloid-derived macrophages, suggesting a novel role for RORalpha in macrophage development and activation, which can impact on metabolism, and inflammation. Copyright © 2020 Hams, Roberts, Bermingham, Hogan, O'Shea, O'Neill and Fallon.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Retinoic Acid Receptor alpha).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffimmu.2020.01966
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hams&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Role+for+Retinoic+Acid-Related+Orphan+Receptor+Alpha+%28RORalpha%29+Expressing+Macrophages+in+Diet-Induced+Obesity.&volume=11&issue=&spage=1966&epage=&date=2020&doi=10.3389%2Ffimmu.2020.01966&pmid=32973801&sid=OVID:medline
+
+<1183>
+Unique Identifier
+ 32967678
+Title
+ Association between sitting time and non-alcoholic fatty live disease in South Korean population: a cross-sectional study.
+Source
+ Lipids in Health & Disease. 19(1):212, 2020 Sep 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Joo JH; Kim HJ; Park EC; Jang SI
+Authors Full Name
+ Joo, Jae Hong; Kim, Hwi Jun; Park, Eun-Cheol; Jang, Sung-In.
+Institution
+ Joo, Jae Hong. Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea.
+ Joo, Jae Hong. Institute of Health Services Research, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
+ Kim, Hwi Jun. Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea.
+ Kim, Hwi Jun. Institute of Health Services Research, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
+ Kim, Hwi Jun. 27th Infantry Division Medical Dispensary Operation Branch, Hwacheon, Republic of Korea.
+ Park, Eun-Cheol. Institute of Health Services Research, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
+ Park, Eun-Cheol. Department of Preventive Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
+ Jang, Sung-In. Institute of Health Services Research, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. JANGSI@yuhs.ac.
+ Jang, Sung-In. Department of Preventive Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. JANGSI@yuhs.ac.
+MeSH Subject Headings
+ Adult
+ Aged
+ Alanine Transaminase/bl [Blood]
+ Aspartate Aminotransferases/bl [Blood]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ Diabetes Mellitus/pp [Physiopathology]
+ Exercise
+ Female
+ Humans
+ Hypertension/pp [Physiopathology]
+ Logistic Models
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Nutrition Surveys
+ Obesity/pp [Physiopathology]
+ Republic of Korea/ep [Epidemiology]
+ Risk Factors
+ *Sedentary Behavior
+Keyword Heading
+ Hepatic steatosis index
+ Non-alcoholic fatty liver disease
+ Obesity
+ Physical activity
+ Sedentary
+ Sitting time
+ South Korea
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: To examine the association between sitting time and non-alcoholic fatty liver disease among South Koreans aged >=20 years.
+
+ METHODS: Data from the 2016-2018 Korea National Health and Nutrition Examination Survey were used for the analysis. Non-alcoholic fatty liver disease was diagnosed according to a hepatic steatosis index of > 36. Sitting time was categorized into as Q1, Q2, Q3, and Q4 using the age-adjusted quartile with Q4 being the longest sitting hour. Multiple logistic regression analysis was used to examine the association between sitting time and non-alcoholic fatty liver disease in South Korean population.
+
+ RESULTS: A total of 13,518 participants were enrolled. The odds for having NAFLD in Q1, Q2, Q3, and Q4 (sitting hours) were 1.07 (CI: 0.88-1.31), 1.16 (CI: 1.96-1.41), and 1.34 (CI: 1.11-1.61), respectively. The odds ratio increased in magnitude with longer hours of sitting time (test for trend: P-value = 0.0002).
+
+ CONCLUSION: Advising physical exercises and discouraging sedentary activities may help to alleviate NAFLD among the South Korean population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12944-020-01385-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Joo&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Association+between+sitting+time+and+non-alcoholic+fatty+live+disease+in+South+Korean+population%3A+a+cross-sectional+study.&volume=19&issue=1&spage=212&epage=&date=2020&doi=10.1186%2Fs12944-020-01385-6&pmid=32967678&sid=OVID:medline
+
+<1184>
+Unique Identifier
+ 32954829
+Title
+ An obesogenic maternal environment impairs mouse growth patterns, satellite cell activation, and markers of postnatal myogenesis.
+Source
+ American Journal of Physiology - Endocrinology & Metabolism. 319(6):E1008-E1018, 2020 12 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mikovic J; Brightwell C; Lindsay A; Wen Y; Kowalski G; Russell AP; Fry CS; Lamon S
+Author NameID
+ Wen, Yuan; ORCID: https://orcid.org/0000-0002-3210-1629
+ Russell, Aaron P; ORCID: https://orcid.org/0000-0002-7323-9501
+ Fry, Christopher S; ORCID: https://orcid.org/0000-0002-4207-6594
+ Lamon, Severine; ORCID: https://orcid.org/0000-0002-3271-6551
+Authors Full Name
+ Mikovic, Jasmine; Brightwell, Camille; Lindsay, Angus; Wen, Yuan; Kowalski, Greg; Russell, Aaron P; Fry, Christopher S; Lamon, Severine.
+Institution
+ Mikovic, Jasmine. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
+ Brightwell, Camille. Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky.
+ Lindsay, Angus. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
+ Wen, Yuan. Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky.
+ Kowalski, Greg. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
+ Russell, Aaron P. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
+ Fry, Christopher S. Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky.
+ Lamon, Severine. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
+MeSH Subject Headings
+ Animals
+ Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ Female
+ *Growth and Development/ph [Physiology]
+ Male
+ Maternal Nutritional Physiological Phenomena
+ Mice
+ Mice, Inbred C57BL
+ MicroRNAs/ge [Genetics]
+ MicroRNAs/me [Metabolism]
+ *Muscle Development/ph [Physiology]
+ Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ Overnutrition/co [Complications]
+ Overnutrition/pp [Physiopathology]
+ Pregnancy
+ Pregnancy Complications/et [Etiology]
+ Pregnancy Complications/pp [Physiopathology]
+ Prenatal Exposure Delayed Effects/et [Etiology]
+ Prenatal Exposure Delayed Effects/pp [Physiopathology]
+ *Prenatal Exposure Delayed Effects
+ *Satellite Cells, Skeletal Muscle/ph [Physiology]
+Keyword Heading
+ fetal programming
+ microRNA
+ myogenesis
+ regeneration
+ skeletal muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Skeletal muscle is sensitive to environmental cues that are first present in utero. Maternal overnutrition is a model of impaired muscle development leading to structural and metabolic dysfunction in adult life. In this study, we investigated the effect of an obesogenic maternal environment on growth and postnatal myogenesis in the offspring. Male C57BL/6J mice born to chow- or high-fat-diet-fed mothers were allocated to four different groups at the end of weaning. For the following 10 wk, half of the pups were maintained on the same diet as their mother and half of the pups were switched to the other diet (chow or high-fat). At 12 wk of age, muscle injury was induced using an intramuscular injection of barium chloride. Seven days later, mice were humanely killed and muscle tissue was harvested. A high-fat maternal diet impaired offspring growth patterns and downregulated satellite cell activation and markers of postnatal myogenesis 7 days after injury without altering the number of newly synthetized fibers over the whole 7-day period. Importantly, a healthy postnatal diet could not reverse any of these effects. In addition, we demonstrated that postnatal myogenesis was associated with a diet-independent upregulation of three miRNAs, mmu-miR-31-5p, mmu-miR-136-5p, and mmu-miR-296-5p. Furthermore, in vitro analysis confirmed the role of these miRNAs in myocyte proliferation. Our findings are the first to demonstrate that maternal overnutrition impairs markers of postnatal myogenesis in the offspring and are particularly relevant to today's society where the incidence of overweight/obesity in women of childbearing age is increasing.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1152%2fajpendo.00398.2020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mikovic&issn=0193-1849&title=American+Journal+of+Physiology+-+Endocrinology+%26+Metabolism&atitle=An+obesogenic+maternal+environment+impairs+mouse+growth+patterns%2C+satellite+cell+activation%2C+and+markers+of+postnatal+myogenesis.&volume=319&issue=6&spage=E1008&epage=E1018&date=2020&doi=10.1152%2Fajpendo.00398.2020&pmid=32954829&sid=OVID:medline
+
+<1185>
+Unique Identifier
+ 32952453
+Title
+ Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men.
+Source
+ Thescientificworldjournal. 2020:1897027, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rashid FA; Abbas HJ; Naser NA; Addai Ali H
+Author NameID
+ Rashid, Farah A; ORCID: https://orcid.org/0000-0001-7211-6158
+Authors Full Name
+ Rashid, Farah A; Abbas, Hamid Jaddoa; Naser, Naser Ali; Addai Ali, Hana'a.
+Institution
+ Rashid, Farah A. Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.
+ Abbas, Hamid Jaddoa. Alzahraa Medical College, Basrah, Iraq.
+ Naser, Naser Ali. Al-Faiha'a Teaching Hospital, Basrah, Iraq.
+ Addai Ali, Hana'a. Department of Chemistry, College of Science, University of Kufa, Najaf, Iraq.
+MeSH Subject Headings
+ Biomarkers
+ Blood Glucose
+ Body Mass Index
+ Body Weight
+ Case-Control Studies
+ *Energy Metabolism
+ *Exercise
+ Female
+ *Fibronectins/me [Metabolism]
+ Humans
+ Insulin/me [Metabolism]
+ Insulin Resistance
+ Male
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Time Factors
+Abstract
+ BACKGROUND: Irisin is a myokine that has a beneficial effect on obesity and glucose metabolism by increasing energy expenditure. This study aims to investigate the effect of long-term moderate physical exercise on irisin levels and its correlations with body mass index (BMI), waist circumferences (WC), and metabolic parameters in normal weight and obese males. Material and method. A follow-up case-control study of sixty male participants, comprised of thirty normal weight and thirty obese, who had undergone supervised long-term moderate physical exercises for six months. Serum irisin levels, fasting blood glucose, serum insulin, homeostatic model assessment of the insulin resistance index (HOMA-IR), and beta-cell function (HOMA-B2) were assessed.
+
+ RESULTS: Long-term moderate exercise induced elevation of the irisin level significantly (P < 0.0001) with significant reduction of the BMI, WC, fasting blood glucose, insulin, HOMA-IR, and HOMA-B2 levels (P < 0.0001) in comparison between obese and normal weight groups. There are significant differences for each parameter in each obese and normal weight group before and after physical exercise with exception of the BMI and WC in the normal group. Significant negative correlations were shown between irisin and blood glucose and insulin and HOMA-IR levels in the obese group and normal weight group.
+
+ CONCLUSION: Irisin improves glucose homeostasis after long-term moderate physical exercises, suggesting that irisin could have regulatory effect on glucose, insulin resistance, and obesity and it could be used as a potential therapy for obesity and insulin resistance. Copyright © 2020 Farah A. Rashid et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (FNDC5 protein, human). 0 (Fibronectins). 0 (Insulin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1155%2f2020%2f1897027
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rashid&issn=1537-744X&title=Thescientificworldjournal&atitle=Effect+of+Long-Term+Moderate+Physical+Exercise+on+Irisin+between+Normal+Weight+and+Obese+Men.&volume=2020&issue=&spage=1897027&epage=&date=2020&doi=10.1155%2F2020%2F1897027&pmid=32952453&sid=OVID:medline
+
+<1186>
+Unique Identifier
+ 32947866
+Title
+ Gut Microbiota-Mediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer.
+Source
+ International Journal of Molecular Sciences. 21(18), 2020 Sep 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sanchez-Alcoholado L; Ordonez R; Otero A; Plaza-Andrade I; Laborda-Illanes A; Medina JA; Ramos-Molina B; Gomez-Millan J; Queipo-Ortuno MI
+Author NameID
+ Ramos-Molina, Bruno; ORCID: https://orcid.org/0000-0001-6804-5449
+ Queipo-Ortuno, Maria Isabel; ORCID: https://orcid.org/0000-0002-2867-0845
+Authors Full Name
+ Sanchez-Alcoholado, Lidia; Ordonez, Rafael; Otero, Ana; Plaza-Andrade, Isaac; Laborda-Illanes, Aurora; Medina, Jose Antonio; Ramos-Molina, Bruno; Gomez-Millan, Jaime; Queipo-Ortuno, Maria Isabel.
+Institution
+ Sanchez-Alcoholado, Lidia. Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA)-CIMES-UMA, 29010 Malaga, Spain.
+ Sanchez-Alcoholado, Lidia. Facultad de Medicina, Universidad de Malaga, Campus de Teatinos s/n, 29071 Malaga, Spain.
+ Ordonez, Rafael. Unidad de Gestion Clinica de Oncologia Radioterapica, Hospital Universitario Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Otero, Ana. Unidad de Gestion Clinica de Oncologia Radioterapica, Hospital Universitario Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Plaza-Andrade, Isaac. Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA)-CIMES-UMA, 29010 Malaga, Spain.
+ Laborda-Illanes, Aurora. Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA)-CIMES-UMA, 29010 Malaga, Spain.
+ Laborda-Illanes, Aurora. Facultad de Medicina, Universidad de Malaga, Campus de Teatinos s/n, 29071 Malaga, Spain.
+ Medina, Jose Antonio. Unidad de Gestion Clinica de Oncologia Radioterapica, Hospital Universitario Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Ramos-Molina, Bruno. Grupo de Cirugia Digestiva, Endocrina y Transplante de Organos Abdominales, Instituto Murciano de Investigacion Biosanitaria (IMIB-Arrixaca), 30120 Murcia, Spain.
+ Gomez-Millan, Jaime. Unidad de Gestion Clinica de Oncologia Radioterapica, Hospital Universitario Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
+ Queipo-Ortuno, Maria Isabel. Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen de la Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA)-CIMES-UMA, 29010 Malaga, Spain.
+MeSH Subject Headings
+ Aged
+ Bacteria/cl [Classification]
+ Bacteria/ge [Genetics]
+ *Bacteria/ip [Isolation & Purification]
+ Bacteria/me [Metabolism]
+ Biomarkers
+ Body Mass Index
+ Colorectal Neoplasms/et [Etiology]
+ *Colorectal Neoplasms/mi [Microbiology]
+ Colorectal Neoplasms/pa [Pathology]
+ Colorectal Neoplasms/pp [Physiopathology]
+ Dysbiosis/co [Complications]
+ *Dysbiosis/mi [Microbiology]
+ Dysbiosis/pa [Pathology]
+ Dysbiosis/pp [Physiopathology]
+ Feces/mi [Microbiology]
+ Female
+ *Gastrointestinal Microbiome/ph [Physiology]
+ Haptoglobins
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/mi [Microbiology]
+ Inflammation Mediators/bl [Blood]
+ Interleukins/bl [Blood]
+ Male
+ Metagenome
+ Methylamines/ae [Adverse Effects]
+ Methylamines/bl [Blood]
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Obesity/mi [Microbiology]
+ Obesity/pa [Pathology]
+ Obesity/pp [Physiopathology]
+ Permeability
+ Protein Precursors/bl [Blood]
+Keyword Heading
+ TMAO
+ colorectal cancer
+ gut microbiota
+ gut permeability
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is considered an important factor that increases the risk of colorectal cancer (CRC). So far, the association of gut microbiota with both obesity and cancer has been described independently. Nevertheless, a specific obesity-related microbial profile linked to CRC development has not been identified. The aim of this study was to determine the gut microbiota composition in fecal samples from CRC patients with (OB-CRC) and without obesity (L-CRC) compared to the microbiota profile present in non-obese healthy controls (L-HC), in order to unravel the possible relationship between gut microbiota and microbial-derived metabolite trimethylamine N-oxide (TMAO), the inflammatory status, and the intestinal permeability in the context of obesity-associated CRC. The presence of obesity does not induce significant changes in the diversity and richness of intestinal bacteria of CRC patients. Nevertheless, OB-CRC patients display a specific gut microbiota profile characterized by a reduction in butyrate-producing bacteria and an overabundance of opportunistic pathogens, which in turn could be responsible, at least in part, for the higher levels of proinflammatory cytokine IL-1beta, the deleterious bacterial metabolite TMAO, and gut permeability found in these patients. These results suggest a possible role of obesity-related gut microbiota in the development of CRC, which could give new clues for the design of new diagnostic tools for CRC prevention.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Haptoglobins). 0 (Inflammation Mediators). 0 (Interleukins). 0 (Methylamines). 0 (Protein Precursors). 0 (zonulin). FLD0K1SJ1A (trimethyloxamine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21186782
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sanchez-Alcoholado&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Gut+Microbiota-Mediated+Inflammation+and+Gut+Permeability+in+Patients+with+Obesity+and+Colorectal+Cancer.&volume=21&issue=18&spage=6782&epage=&date=2020&doi=10.3390%2Fijms21186782&pmid=32947866&sid=OVID:medline
+
+<1187>
+Unique Identifier
+ 32935815
+Title
+ Comment on "Plasmatic adipocyte biomarkers and foot pain associated with flatfoot in schoolchildren with obesity".
+Source
+ Revista Da Associacao Medica Brasileira. 66(8):1164-1165, 2020 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gabr SA
+Author NameID
+ Gabr, Sami A; ORCID: https://orcid.org/0000-0001-5071-291X
+Authors Full Name
+ Gabr, Sami A.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Adipocytes
+ Biomarkers
+ Child
+ *Flatfoot
+ Humans
+ Obesity/co [Complications]
+ Pain/et [Etiology]
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Comment.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1590%2f1806-9282.66.8.1164
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gabr&issn=0104-4230&title=Revista+Da+Associacao+Medica+Brasileira&atitle=Comment+on+%22Plasmatic+adipocyte+biomarkers+and+foot+pain+associated+with+flatfoot+in+schoolchildren+with+obesity%22.&volume=66&issue=8&spage=1164&epage=1165&date=2020&doi=10.1590%2F1806-9282.66.8.1164&pmid=32935815&sid=OVID:medline
+
+<1188>
+Unique Identifier
+ 32933141
+Title
+ Predicting Nonalcoholic Fatty Liver Disease through a Panel of Plasma Biomarkers and MicroRNAs in Female West Virginia Population.
+Source
+ International Journal of Molecular Sciences. 21(18), 2020 Sep 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pillai SS; Lakhani HV; Zehra M; Wang J; Dilip A; Puri N; O'Hanlon K; Sodhi K
+Author NameID
+ Sodhi, Komal; ORCID: https://orcid.org/0000-0002-1179-2985
+Authors Full Name
+ Pillai, Sneha S; Lakhani, Hari Vishal; Zehra, Mishghan; Wang, Jiayan; Dilip, Anum; Puri, Nitin; O'Hanlon, Kathleen; Sodhi, Komal.
+Institution
+ Pillai, Sneha S. Departments of Surgery and Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
+ Lakhani, Hari Vishal. Departments of Surgery and Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
+ Zehra, Mishghan. Departments of Surgery and Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
+ Wang, Jiayan. Departments of Surgery and Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
+ Dilip, Anum. Departments of Surgery and Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
+ Puri, Nitin. Departments of Biomedical Sciences and Medical Education, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
+ O'Hanlon, Kathleen. Departments of Family Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
+ Sodhi, Komal. Departments of Surgery and Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adult
+ *Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Disease Progression
+ Female
+ Humans
+ Leptin/bl [Blood]
+ Liver/me [Metabolism]
+ *MicroRNAs/bl [Blood]
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/me [Metabolism]
+ *Plasma/me [Metabolism]
+ West Virginia
+Keyword Heading
+ biomarker
+ diabetes
+ miRNA
+ nonalcoholic fatty liver disease
+ nonalcoholic steatohepatitis
+ obese
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ (1) Background: Nonalcoholic fatty liver disease (NAFLD) is primarily characterized by the presence of fatty liver, hepatic inflammation and fibrogenesis eventually leading to nonalcoholic steatohepatitis (NASH) or cirrhosis. Obesity and diabetes are common risk factors associated with the development and progression of NAFLD, with one of the highest prevalence of these diseased conditions in the West Virginia population. Currently, the diagnosis of NAFLD is limited to radiologic studies and biopsies, which are not cost-effective and highly invasive. Hence, this study aimed to develop a panel and assess the progressive levels of circulatory biomarkers and miRNA expression in patients at risk for progression to NASH to allow early intervention strategies. (2) Methods: In total, 62 female patients were enrolled and blood samples were collected after 8-10 h of fasting. Computed tomography was performed on abdomen/pelvis following IV contrast administration. The patients were divided into the following groups: Healthy subjects with normal BMI and normal fasting blood glucose (Control, n = 20), Obese with high BMI and normal fasting blood glucose (Obese, n = 20) and Obese with high fasting blood glucose (Obese + DM, n = 22). Based on findings from CT, another subset was created from Obese + DM group with patients who showed signs of fatty liver infiltration (Obese + DM(FI), n = 10). ELISA was performed for measurement of plasma biomarkers and RT-PCR was performed for circulating miRNA expression. (3) Results: Our results show significantly increased levels of plasma IL-6, Leptin and FABP-1, while significantly decreased level of adiponectin in Obese, Obese + DM and Obese + DM(FI) group, as compared to healthy controls. The level of CK-18 was significantly increased in Obese + DM(FI) group as compared to control. Subsequently, the expression of miR-122, miR-34a, miR-375, miR-16 and miR-21 was significantly increased in Obese + DM and Obese + DM(FI) group as compared to healthy control. Our results also show distinct correlation of IL-6, FABP-1 and adiponectin levels with the expression of miRNAs in relation to the extent of NAFLD progression. (4) Conclusion: Our results support the clinical application of these biomarkers and miRNAs in monitoring the progression of NAFLD, suggesting a more advanced diagnostic potential of this panel than conventional methods. This panel may provide an appropriate method for early prognosis and management of NAFLD and subsequent adverse hepatic pathophysiology, potentially reducing the disease burden on the West Virginia population.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Leptin). 0 (MicroRNAs).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21186698
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pillai&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Predicting+Nonalcoholic+Fatty+Liver+Disease+through+a+Panel+of+Plasma+Biomarkers+and+MicroRNAs+in+Female+West+Virginia+Population.&volume=21&issue=18&spage=6698&epage=&date=2020&doi=10.3390%2Fijms21186698&pmid=32933141&sid=OVID:medline
+
+<1189>
+Unique Identifier
+ 32917958
+Title
+ Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity.
+Source
+ Experimental & Molecular Medicine. 52(9):1574-1586, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yoon Y; Kim G; Noh MG; Park JH; Jang M; Fang S; Park H
+Author NameID
+ Fang, Sungsoon; ORCID: http://orcid.org/0000-0003-0201-5567
+Authors Full Name
+ Yoon, Youngmin; Kim, Gihyeon; Noh, Myung-Giun; Park, Jeong-Hyeon; Jang, Mongjoo; Fang, Sungsoon; Park, Hansoo.
+Institution
+ Yoon, Youngmin. Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
+ Kim, Gihyeon. Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
+ Noh, Myung-Giun. Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
+ Park, Jeong-Hyeon. Genome and Company, Pangyo-ro 255, Bundang-gu, Seoungnam, Korea.
+ Jang, Mongjoo. Genome and Company, Pangyo-ro 255, Bundang-gu, Seoungnam, Korea.
+ Fang, Sungsoon. Severance Biomedical Science Institute, BK21 PLUS Project for Medical Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. sfang@yuhs.ac.
+ Park, Hansoo. Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea. hspark27@gist.ac.kr.
+ Park, Hansoo. Genome and Company, Pangyo-ro 255, Bundang-gu, Seoungnam, Korea. hspark27@gist.ac.kr.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Body Weight
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Susceptibility
+ Gastrointestinal Microbiome
+ Gene Expression Profiling
+ *Limosilactobacillus fermentum/ph [Physiology]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Metabolomics/mt [Methods]
+ Mice
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Oxidative Phosphorylation
+ *Probiotics
+ Signal Transduction
+Abstract
+ The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates diet-induced obesity in humans and mice. However, the mechanisms through which Lactobacillus spp. control host metabolic homeostasis remain unclear. Accordingly, in this study, we evaluated the physiological roles of Lactobacillus fermentum in controlling metabolic homeostasis in diet-induced obesity. Our results demonstrated that L. fermentum-potentiated oxidative phosphorylation in adipose tissue, resulting in increased energy expenditure to protect against diet-induced obesity. Indeed, oral administration of L. fermentum LM1016 markedly ameliorated glucose clearance and fatty liver in high-fat diet-fed mice. Moreover, administration of L. fermentum LM1016 markedly decreased inflammation and increased oxidative phosphorylation in gonadal white adipose tissue, as demonstrated by transcriptome analysis. Finally, metabolome analysis showed that metabolites derived from L. fermentum LM1016-attenuated adipocyte differentiation and inflammation in 3T3-L1 preadipocytes. These pronounced metabolic improvements suggested that the application of L. fermentum LM1016 could have clinical applications for the treatment of metabolic syndromes, such as diet-induced obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs12276-020-00502-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yoon&issn=1226-3613&title=Experimental+%26+Molecular+Medicine&atitle=Lactobacillus+fermentum+promotes+adipose+tissue+oxidative+phosphorylation+to+protect+against+diet-induced+obesity.&volume=52&issue=9&spage=1574&epage=1586&date=2020&doi=10.1038%2Fs12276-020-00502-w&pmid=32917958&sid=OVID:medline
+
+<1190>
+Unique Identifier
+ 32917052
+Title
+ The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity.
+Source
+ Biomolecules. 10(9), 2020 09 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Komosinska-Vassev K; Gala O; Olczyk K; Jura-Poltorak A; Olczyk P
+Author NameID
+ Komosinska-Vassev, Katarzyna; ORCID: https://orcid.org/0000-0003-2307-5884
+ Olczyk, Pawel; ORCID: https://orcid.org/0000-0001-7387-9587
+Authors Full Name
+ Komosinska-Vassev, Katarzyna; Gala, Olga; Olczyk, Krystyna; Jura-Poltorak, Agnieszka; Olczyk, Pawel.
+Institution
+ Komosinska-Vassev, Katarzyna. Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.
+ Gala, Olga. Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.
+ Olczyk, Krystyna. Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.
+ Jura-Poltorak, Agnieszka. Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.
+ Olczyk, Pawel. Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Female
+ *Fibronectins/bl [Blood]
+ Fibronectins/ge [Genetics]
+ Gene Expression Regulation
+ Glycated Hemoglobin/ge [Genetics]
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ Insulin/bl [Blood]
+ Insulin/ge [Genetics]
+ Insulin Resistance
+ *Intercellular Signaling Peptides and Proteins/bl [Blood]
+ Intercellular Signaling Peptides and Proteins/ge [Genetics]
+ Kidney Function Tests
+ Male
+ *Metformin/tu [Therapeutic Use]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/dt [Drug Therapy]
+ Obesity/ge [Genetics]
+ Prognosis
+ *Serpins/bl [Blood]
+ Serpins/ge [Genetics]
+ Signal Transduction
+Keyword Heading
+ adipocytokines
+ adropin
+ irisin
+ metformin therapy
+ obesity
+ type 2 diabetes mellitus
+ vaspin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The quantitative analysis of selected regulatory molecules, i.e., adropin, irisin, and vaspin in the plasma of obese patients with newly diagnosed, untreated type 2 diabetes mellitus, and in the same patients after six months of using metformin, in relation to adropinemia, irisinemia and vaspinemia in obese individuals, was performed. The relationship between plasma concentration of the adipocytokines/regulatory peptides and parameters of renal function (albumin/creatinine ratio-ACR, estimated glomerular filtration rate-eGFR), values of insulin resistance indicators (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR2), Homeostatic Model Assessment of Insulin Sensitivity (HOMA-S), Homeostatic Model Assessment of beta-cell function (HOMA-B), quantitative insulin sensitivity check index (QUICKI), insulin), and parameters of carbohydrate-lipid metabolism (fasting plasma glucose-FPG, glycated hemoglobin-HbA1C, estimated glucose disposal rate-eGDR, fasting lipid profile, TG/HDL ratio) in obese type 2 diabetic patients was also investigated. Circulating irisin and vaspin were found significantly different in subjects with metabolically healthy obesity and in type 2 diabetic patients. Significant increases in blood levels of both analyzed adipokines/regulatory peptides were observed in diabetic patients after six months of metformin treatment, as compared to pre-treatment levels. The change in plasma vaspin level in response to metformin therapy was parallel with the improving of insulin resistance/sensitivity parameters. An attempt was made to identify a set of biochemical tests that would vary greatly in obese non-diabetic subjects and obese patients with type 2 diabetes, as well as a set of parameters that are changing in patients with type 2 diabetes under the influence of six months metformin therapy, and thus differentiating patients' metabolic state before and after treatment. For these data analyses, both statistical measures of strength of the relationships of individual parameters, as well as multidimensional methods, including discriminant analysis and multifactorial analysis derived from machine learning methods, were used. Adropin, irisin, and vaspin were found as promising regulatory molecules, which may turn out to be useful indicators in the early detection of T2DM and differentiating the obesity phenotype with normal metabolic profile from T2DM obese patients. Multifactorial discriminant analysis revealed that irisin and vaspin plasma levels contribute clinically relevant information concerning the effectiveness of metformin treatment in T2D patients. Among the sets of variables differentiating with the highest accuracy the metabolic state of patients before and after six-month metformin treatment, were: (1) vaspin, HbA1c, HDL, LDL, TG, insulin, and HOMA-B (ACC = 88 [%]); (2) vaspin, irisin, QUICKI, and eGDR (ACC = 86 [%]); as well as, (3) vaspin, irisin, LDL, HOMA-S, ACR, and eGFR (ACC = 86 [%]).
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Blood Glucose). 0 (Enho protein, human). 0 (FNDC5 protein, human). 0 (Fibronectins). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (Insulin). 0 (Intercellular Signaling Peptides and Proteins). 0 (SERPINA12 protein, human). 0 (Serpins). 0 (hemoglobin A1c protein, human). 9100L32L2N (Metformin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fbiom10091304
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Komosinska-Vassev&issn=2218-273X&title=Biomolecules&atitle=The+Usefulness+of+Diagnostic+Panels+Based+on+Circulating+Adipocytokines%2FRegulatory+Peptides%2C+Renal+Function+Tests%2C+Insulin+Resistance+Indicators+and+Lipid-Carbohydrate+Metabolism+Parameters+in+Diagnosis+and+Prognosis+of+Type+2+Diabetes+Mellitus+with+Obesity.&volume=10&issue=9&spage=&epage=&date=2020&doi=10.3390%2Fbiom10091304&pmid=32917052&sid=OVID:medline
+
+<1191>
+Unique Identifier
+ 32915209
+Title
+ Maternal high fat diet-induced obesity affects trophoblast differentiation and placental function in mice .
+Source
+ Biology of Reproduction. 103(6):1260-1274, 2020 12 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kretschmer T; Turnwald EM; Janoschek R; Zentis P; Bae-Gartz I; Beers T; Handwerk M; Wohlfarth M; Ghilav M; Bloch W; Hucklenbruch-Rother E; Dotsch J; Appel S
+Authors Full Name
+ Kretschmer, Tobias; Turnwald, Eva-Maria; Janoschek, Ruth; Zentis, Peter; Bae-Gartz, Inga; Beers, Tim; Handwerk, Marion; Wohlfarth, Maria; Ghilav, Mojgan; Bloch, Wilhelm; Hucklenbruch-Rother, Eva; Dotsch, Jorg; Appel, Sarah.
+Institution
+ Kretschmer, Tobias. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Kretschmer, Tobias. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
+ Turnwald, Eva-Maria. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Janoschek, Ruth. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Zentis, Peter. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Core Facility Imaging, University of Cologne, Cologne, Germany.
+ Bae-Gartz, Inga. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Beers, Tim. Department of Anatomy I, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Handwerk, Marion. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Wohlfarth, Maria. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Ghilav, Mojgan. Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.
+ Bloch, Wilhelm. Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.
+ Hucklenbruch-Rother, Eva. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Dotsch, Jorg. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+ Appel, Sarah. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cell Adhesion
+ Cell Differentiation
+ *Diet, High-Fat/ae [Adverse Effects]
+ Female
+ Gene Expression Regulation
+ Mice
+ Mice, Inbred C57BL
+ *Obesity/ci [Chemically Induced]
+ *Placenta/de [Drug Effects]
+ Placenta/ph [Physiology]
+ Placenta/ul [Ultrastructure]
+ Pregnancy
+ Proteomics
+ Random Allocation
+ Transcriptome
+ *Trophoblasts/de [Drug Effects]
+Keyword Heading
+ E-cadherin
+ beta-catenin
+ labyrinth zone ultrastructure
+ linoleic acid
+ materno-fetal transfer capacity
+ placental proteomics profiling
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Evidence suggests that maternal obesity (MO) can aggravate placental function causing severe pathologies during the perinatal window. However, molecular changes and mechanisms of placental dysfunction remain largely unknown. This work aimed to decipher structural and molecular alterations of the placental transfer zone associated with MO. To this end, mice were fed a high fat diet (HFD) to induce obesity before mating, and pregnant dams were sacrificed at E15.5 to receive placentas for molecular, histological, and ultrastructural analysis and to assess unidirectional materno-fetal transfer capacity. Laser-capture microdissection was used to collect specifically placental cells of the labyrinth zone for proteomics profiling. Using BeWo cells, fatty acid-mediated mechanisms of adherens junction stability, cell layer permeability, and lipid accumulation were deciphered. Proteomics profiling revealed downregulation of cell adhesion markers in the labyrinth zone of obese dams, and disturbed syncytial fusion and detachment of the basement membrane (BM) within this zone was observed, next to an increase in materno-fetal transfer in vivo across the placenta. We found that fetuses of obese dams develop a growth restriction and in those placentas, labyrinth zone volume-fraction was significantly reduced. Linoleic acid was shown to mediate beta-catenin level and increase cell layer permeability in vitro. Thus, MO causes fetal growth restriction, molecular and structural changes in the transfer zone leading to impaired trophoblast differentiation, BM disruption, and placental dysfunction despite increased materno-fetal transfer capacity. These adverse effects are probably mediated by fatty acids found in HFD demonstrating the need for obesity treatment to mitigate placental dysfunction and prevent offspring pathologies. Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1093%2fbiolre%2fioaa166
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kretschmer&issn=0006-3363&title=Biology+of+Reproduction&atitle=Maternal+high+fat+diet-induced+obesity+affects+trophoblast+differentiation+and+placental+function+in+mice+.&volume=103&issue=6&spage=1260&epage=1274&date=2020&doi=10.1093%2Fbiolre%2Fioaa166&pmid=32915209&sid=OVID:medline
+
+<1192>
+Unique Identifier
+ 32905941
+Title
+ Evaluation of ABO blood group in subjects with CVD risk factors in a population sample from northeastern Iran.
+Source
+ Diabetes & Metabolic Syndrome. 14(6):1689-1695, 2020 Nov-Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yaghooti-Khorasani M; Ghazizadeh H; Bijari M; Mohammadi-Bajgiran M; Oladi MR; Zare-Feizabadi R; Timar A; Nazarpour S; Khedmatgozar H; Rohban M; Hasanzadeh E; Javandoost A; Banpoor H; Sheikh Andalibi MS; Moazedi S; Mosalman-Zadeh N; Aghasizadeh M; Ferns GA; Esmaily H; Ghayour-Mobarhan M
+Authors Full Name
+ Yaghooti-Khorasani, Mahdiyeh; Ghazizadeh, Hamideh; Bijari, Moniba; Mohammadi-Bajgiran, Maryam; Oladi, Mohammad Reza; Zare-Feizabadi, Reza; Timar, Ameneh; Nazarpour, Shahin; Khedmatgozar, Hamed; Rohban, Mohadeseh; Hasanzadeh, Elahe; Javandoost, Ali; Banpoor, Hamed; Sheikh Andalibi, Mohammad Sobhan; Moazedi, Sara; Mosalman-Zadeh, Negin; Aghasizadeh, Maliheh; Ferns, Gordon A; Esmaily, Habibollah; Ghayour-Mobarhan, Majid.
+Institution
+ Yaghooti-Khorasani, Mahdiyeh. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ghazizadeh, Hamideh. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Bijari, Moniba. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Mohammadi-Bajgiran, Maryam. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Oladi, Mohammad Reza. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Zare-Feizabadi, Reza. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Timar, Ameneh. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Nazarpour, Shahin. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Khedmatgozar, Hamed. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Center for Biotechnology and Genomics, Texas Tech University, Lubbock, TX, USA.
+ Rohban, Mohadeseh. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Hasanzadeh, Elahe. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
+ Javandoost, Ali. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Banpoor, Hamed. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Sheikh Andalibi, Mohammad Sobhan. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Moazedi, Sara. Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
+ Mosalman-Zadeh, Negin. Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
+ Aghasizadeh, Maliheh. Student Research Committee, Department of Molecular Medicine, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
+ Ferns, Gordon A. Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex, UK.
+ Esmaily, Habibollah. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: esmailyh@mums.ac.ir.
+ Ghayour-Mobarhan, Majid. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghayourm@mums.ac.ir.
+MeSH Subject Headings
+ *ABO Blood-Group System/bl [Blood]
+ *Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Cross-Sectional Studies
+ Diabetes Mellitus/pp [Physiopathology]
+ Dyslipidemias/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Heat-Shock Proteins/bl [Blood]
+ Heat-Shock Proteins/im [Immunology]
+ Humans
+ Hypertension/pp [Physiopathology]
+ Iran/ep [Epidemiology]
+ Male
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ Molecular Chaperones/bl [Blood]
+ Molecular Chaperones/im [Immunology]
+ Obesity/pp [Physiopathology]
+ *Oxidants/bl [Blood]
+ Prognosis
+ *Reactive Oxygen Species/bl [Blood]
+ Risk Factors
+Keyword Heading
+ ABO blood group
+ Anti-heat-shock protein 27
+ Cardiovascular disease
+ High sensitivity C-reactive protein
+ Pro-oxidant-antioxidant balance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: The ABO blood group system is a genetic polymorphism which can affect the clearance of von Willebrand factor. We aimed to assess the levels of newer biomarkers of cardiovascular disease (CVD) risk; pro-oxidant-antioxidant balance (PAB), high sensitivity C-reactive protein (hs-CRP) and anti-heat-shock protein27 (anti-Hsp27) antibody titers in subjects with various blood groups (A, B, AB and O) and with or without traditional CVD risk factors.
+
+ METHODS: The cross-sectional study comprised 6910 subjects. Antigen-antibody agglutination was evaluated by the slide test method for identification of ABO blood groups.
+
+ RESULTS: Among three markers, only Serum anti-Hsp27 titers significantly differed between the four blood groups and showed the highest and lowest values in AB and O blood groups (0.26 +/- 0.22 and 0.23 +/- 0.18 OD, respectively; P < 0.05). Serum anti-Hsp27 was higher in individuals with an AB blood group with metabolic syndrome (MetS), dyslipidemia, hypertension (HTN) and obesity and it was lower in subjects with O blood group; though, two other biomarkers, serum PAB and hs-CRP, were not significantly different between the ABO blood groups. However, they were not different among blood groups in participants with or without diabetes mellitus (DM) (P > 0.05).
+
+ CONCLUSION: Individuals with an AB blood group and high levels of anti-Hsp27 antibody titers may be predisposed to CVDs that can be mediated through the traditional CVD risk factors among middle-aged subjects from northeastern Iran. The fact that differences in anti Hsp27 are only found in the subgroup with other risk factors suggest that the difference between ABO blood groups is a consequence rather than a cause. Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ABO Blood-Group System). 0 (Biomarkers). 0 (HSPB1 protein, human). 0 (Heat-Shock Proteins). 0 (Molecular Chaperones). 0 (Oxidants). 0 (Reactive Oxygen Species). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.dsx.2020.08.031
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yaghooti-Khorasani&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Evaluation+of+ABO+blood+group+in+subjects+with+CVD+risk+factors+in+a+population+sample+from+northeastern+Iran.&volume=14&issue=6&spage=1689&epage=1695&date=2020&doi=10.1016%2Fj.dsx.2020.08.031&pmid=32905941&sid=OVID:medline
+
+<1193>
+Unique Identifier
+ 32899471
+Title
+ Transcriptome Analysis of Testis from HFD-Induced Obese Rats (Rattus norvigicus) Indicated Predisposition for Male Infertility.
+Source
+ International Journal of Molecular Sciences. 21(18), 2020 Sep 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ El-Shehawi AM; El-Shazly S; Ahmed M; Alkafafy M; Sayed S; Farouk S; Alotaibi SS; Elseehy MM
+Author NameID
+ El-Shehawi, Ahmed M; ORCID: https://orcid.org/0000-0003-4357-4904
+ El-Shazly, Samir; ORCID: https://orcid.org/0000-0001-6034-4663
+ Alkafafy, Mohamed; ORCID: https://orcid.org/0000-0002-7194-5429
+ Sayed, Samy; ORCID: https://orcid.org/0000-0002-7002-568X
+ Alotaibi, Saqer S; ORCID: https://orcid.org/0000-0002-6162-7953
+Authors Full Name
+ El-Shehawi, Ahmed M; El-Shazly, Samir; Ahmed, Mohamed; Alkafafy, Mohamed; Sayed, Samy; Farouk, Samy; Alotaibi, Saqer S; Elseehy, Mona M.
+Institution
+ El-Shehawi, Ahmed M. Department of Biotechnology, Faculty of Science, Taif University, Taif 21974, Saudi Arabia.
+ El-Shehawi, Ahmed M. Department of Genetics, Faculty of Agriculture, University of Alexandria, Alexandria 21526, Egypt.
+ El-Shazly, Samir. Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr Elsheikh 33511, Egypt.
+ Ahmed, Mohamed. Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32958, Egypt.
+ Alkafafy, Mohamed. Department of Biotechnology, Faculty of Science, Taif University, Taif 21974, Saudi Arabia.
+ Alkafafy, Mohamed. Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32958, Egypt.
+ Sayed, Samy. University College of Ranyah, Taif University, Taif 21974, Saudi Arabia.
+ Sayed, Samy. Faculty of Agriculture, Cairo University, Giza 12613, Egypt.
+ Farouk, Samy. Department of Biotechnology, Faculty of Science, Taif University, Taif 21974, Saudi Arabia.
+ Alotaibi, Saqer S. Department of Biotechnology, Faculty of Science, Taif University, Taif 21974, Saudi Arabia.
+ Elseehy, Mona M. Department of Genetics, Faculty of Agriculture, University of Alexandria, Alexandria 21526, Egypt.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Diet, High-Fat/ae [Adverse Effects]
+ Gene Expression/ge [Genetics]
+ Gene Expression Profiling/mt [Methods]
+ Gene Expression Regulation/ge [Genetics]
+ Gene Ontology
+ Genetic Predisposition to Disease/ge [Genetics]
+ High-Throughput Nucleotide Sequencing/mt [Methods]
+ *Infertility, Male/ge [Genetics]
+ Male
+ Obesity/co [Complications]
+ *Obesity/ge [Genetics]
+ RNA/ge [Genetics]
+ Rats
+ Rats, Wistar
+ Sertoli Cells/me [Metabolism]
+ Spermatozoa/me [Metabolism]
+ *Testis/me [Metabolism]
+ Testis/ph [Physiology]
+ Testosterone/me [Metabolism]
+ Transcriptome/ge [Genetics]
+Keyword Heading
+ gene expression
+ infertility
+ obesity
+ spermatogenesis
+ transcriptome analysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a worldwide life-threatening metabolic disorder, associated with various chronic diseases, including male infertility. Obesity was induced by high fat diet (HFD), and testis RNA was used for the transcriptome analysis using RNAseq via Illumina NovaSeq 6000 System and NovaSeq 6000 Kit. Gene expression level was estimated as FPKM (Fragments Per Kilobase of transcript per Million mapped reads). Differential expressed genes (DEGs) were annotated against gene ontology (GO) and KEGG databases. More than 63.66 million reads per sample were performed with 100 bp cutoff and 6 Gb sequencing depth. Results of this study revealed that 267 GO terms (245 biological processes (BP), 14 cellular components (CC), eight molecular functions (MF)), and 89 KEGG pathways were significantly enriched. Moreover, total numbers of 136 genes were differentially expressed (107 upregulated, 29 downregulated) with
+
+ FC
+
+ >= 2 and bh adjusted <0.05. Interesting DEGs were detected, including obesity and lipid metabolism-related genes, immune response-related genes, cytochrome P450 genes, including aromatase were upregulated, whereas genes related to male fertility and fertilization, cell adhesion, and olfactory receptors were downregulated. The combined expression pattern of the DEGs in obese animals indicated an increase in cholesterol metabolism. Furthermore, high aromatase activity enhances the testosterone turnover into estradiol and lowers the testosterone/estradiol (T/E) ratio, which ultimately reduces fertility. In addition, downregulation of cadherens junction components genes leads to the pre-mature release of sperm from Sertoli cells resulting in the reduction of fertility. Moreover, the downregulation of olfactory receptor genes reduces the chemotaxis capacity of sperms in tracking the oocyte for fertilization, which reduces male fertility. Furthermore, various obesity molecular markers were detected in our transcriptome. The results of this study will enhance our understanding of the molecular network of obesity development, development of obesity novel molecular diagnosis markers, molecular bases of obesity-induced infertility, and the development of anti-obesity drugs.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3XMK78S47O (Testosterone). 63231-63-0 (RNA).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21186493
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=El-Shehawi&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Transcriptome+Analysis+of+Testis+from+HFD-Induced+Obese+Rats+%28Rattus+norvigicus%29+Indicated+Predisposition+for+Male+Infertility.&volume=21&issue=18&spage=6493&epage=&date=2020&doi=10.3390%2Fijms21186493&pmid=32899471&sid=OVID:medline
+
+<1194>
+Unique Identifier
+ 32898995
+Title
+ Validating candidate biomarkers for different stages of non-alcoholic fatty liver disease.
+Source
+ Medicine. 99(36):e21463, 2020 Sep 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Qarni R; Iqbal M; Al-Otaibi M; Al-Saif F; Alfadda AA; Alkhalidi H; Bamehriz F; Hassanain M
+Authors Full Name
+ Al-Qarni, Reem; Iqbal, Muhammad; Al-Otaibi, Maram; Al-Saif, Faisal; Alfadda, Assim A; Alkhalidi, Hisham; Bamehriz, Fahad; Hassanain, Mazen.
+Institution
+ Al-Qarni, Reem. Department of Physiology.
+ Iqbal, Muhammad. Department of Physiology.
+ Al-Otaibi, Maram. Department of Pathology.
+ Al-Saif, Faisal. Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
+ Alfadda, Assim A. Obesity Research Center.
+ Alkhalidi, Hisham. Department of Pathology.
+ Bamehriz, Fahad. Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
+ Hassanain, Mazen. Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
+ Hassanain, Mazen. Department of Oncology, McGill University, Montreal, Quebec, Canada.
+ Hassanain, Mazen. Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/me [Metabolism]
+ Case-Control Studies
+ Disease Progression
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ *Fibrillar Collagens
+ Humans
+ *Lipase
+ Male
+ *Membrane Proteins
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/cl [Classification]
+ *Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ Obesity
+ Real-Time Polymerase Chain Reaction
+ Saudi Arabia
+ Young Adult
+Abstract
+ Non-alcoholic fatty liver disease (NAFLD) is a common chronic condition caused by the accumulation of fat in the liver. NAFLD may range from simple steatosis to advanced cirrhosis, and affects more than 1 billion people around the world. To date, there has been no effective treatment for NAFLD. In this study, we evaluated the expression of 4 candidate NAFLD biomarkers to assess their possible applicability in the classification and treatment of the disease.Twenty-six obese subjects, who underwent bariatric surgery, were recruited and their liver biopsies obtained. Expression of 4 candidate biomarker genes, PNPLA3, COL1A1, PPP1R3B, and KLF6 were evaluated at gene and protein levels by RT-qPCR and enzyme-linked immunosorbent assay (ELISA), respectively.A significant increase in the levels of COL1A1 protein (P = .03) and PNPLA3 protein (P = .03) were observed in patients with fibrosis-stage NAFLD compared to that in patients with steatosis-stage NAFLD. However, no significant differences were found in abundance of PPP1R3B and KLF6 proteins or at the gene level for any of the candidate. This is the first study, to our knowledge, to report on the expression levels of candidate biomarker genes for NAFLD in the Saudi population. Although PNPLA3 and PPP1R3B had been previously suggested as biomarkers for steatosis and KLF6 as a possible marker for the fibrosis stage of NAFLD, our results did not support these findings. However, other studies that had linked PNPLA3 to fibrosis in advanced NAFLD supported our current finding of high PNPLA3 protein in patients with fibrosis. Additionally, our results support COL1A1 protein as a potential biomarker for the fibrosis stage of NAFLD, and indicate its use in the screening of patients with NAFLD. Further studies are required to validate the use of COL1A1 as a biomarker for advanced NAFLD in a larger cohort.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fibrillar Collagens). 0 (Membrane Proteins). 0 (collagen type XXI). EC 3-1-1-3 (Lipase). EC 3-1-1-3 (adiponutrin, human).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1097%2fMD.0000000000021463
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Qarni&issn=0025-7974&title=Medicine&atitle=Validating+candidate+biomarkers+for+different+stages+of+non-alcoholic+fatty+liver+disease.&volume=99&issue=36&spage=e21463&epage=&date=2020&doi=10.1097%2FMD.0000000000021463&pmid=32898995&sid=OVID:medline
+
+<1195>
+Unique Identifier
+ 32893859
+Title
+ Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I-III.
+Source
+ Bioscience Reports. 40(9), 2020 09 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mohamed AA; Shousha WG; Zaki ME; El-Bassyouni HT; El-Hanafi H; Abdo SM
+Authors Full Name
+ Mohamed, Amal Ahmed; Shousha, Wafaa Gh; Zaki, Moushira Erfan; El-Bassyouni, Hala T; El-Hanafi, Hadeel; Abdo, Sara M.
+Institution
+ Mohamed, Amal Ahmed. Biochemistry Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
+ Shousha, Wafaa Gh. Chemistry Department, Division of Biochemistry, Faculty of Science, Helwan University, Cairo, Egypt.
+ Zaki, Moushira Erfan. Biological Anthropology Department, National Research Centre, Cairo, Egypt.
+ El-Bassyouni, Hala T. Clinical Genetics Department, National Research Centre, Cairo, Egypt.
+ El-Hanafi, Hadeel. Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt.
+ Abdo, Sara M. Chemistry Department, Division of Biochemistry, Faculty of Science, Helwan University, Cairo, Egypt.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ C-Reactive Protein/im [Immunology]
+ Disease Progression
+ Egypt
+ Endothelium, Vascular/im [Immunology]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/di [Diagnosis]
+ Inflammation/im [Immunology]
+ Interleukin-12/bl [Blood]
+ Interleukin-12/im [Immunology]
+ Interleukin-6/bl [Blood]
+ Interleukin-6/im [Immunology]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/im [Immunology]
+ Severity of Illness Index
+ Tumor Necrosis Factor-alpha/bl [Blood]
+ Tumor Necrosis Factor-alpha/im [Immunology]
+ Vascular Cell Adhesion Molecule-1/bl [Blood]
+ Vascular Cell Adhesion Molecule-1/im [Immunology]
+ Young Adult
+Keyword Heading
+ IL-12
+ Obesity
+ TNF-alpha
+ body mass index
+ endothelial dysfunction
+ inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is an alarming threat to health in Egypt. More than one in three Egyptians is obese, the highest rate in the world. We aimed to delineate the variability of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes.
+
+ METHODS: Out of 130 females, 70 were categorized into three obesity groups: Class I, body mass index (BMI) 30-34.9 kg/m2; Class II, BMI 35-39.9 kg/m2 and Class III BMI >= 40 kg/m2, besides 60 control subjects. Anthropometric measurements were recorded and serum levels of tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), interleukin (IL) 6 (IL-6), IL-12, soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular adhesion molecule 1 (sVCAM-1) were assessed among participants.
+
+ RESULTS: In all three classes of obesity, significant increase (P <0.05) in BMI, waist-hip ratio, fat mass and body fat mass % were noted. CRP and sVCAM-1 levels were increased among the three obesity groups. TNF-alpha levels were increased in class II and III obesity groups. IL-6 and IL-12 levels were elevated in class I and class III groups. While, ICAM-1 levels were increased in class III obesity group.
+
+ CONCLUSION: Based on individuals' BMI, serum levels of TNF-alpha, CRP, IL-6, IL-12, sVCAM-1 and sICAM-1 are differentially altered with the progression of obesity. We strongly support the hypothesis that, as the obesity rate is still mounting, a subclinical inflammatory reaction has a role in pathogenesis of obesity and emphasize the elevation of endothelial dysfunction in individuals with obesity. Copyright © 2020 The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IL6 protein, human). 0 (Interleukin-6). 0 (TNF protein, human). 0 (Tumor Necrosis Factor-alpha). 0 (Vascular Cell Adhesion Molecule-1). 187348-17-0 (Interleukin-12). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1042%2fBSR20192910
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mohamed&issn=0144-8463&title=Bioscience+Reports&atitle=Inflammatory+and+endothelial+dysfunction+indices+among+Egyptian+females+with+obesity+classes+I-III.&volume=40&issue=9&spage=&epage=&date=2020&doi=10.1042%2FBSR20192910&pmid=32893859&sid=OVID:medline
+
+<1196>
+Unique Identifier
+ 32892690
+Title
+ RAGE signalling in obesity and diabetes: focus on the adipose tissue macrophage. [Review]
+Source
+ Adipocyte. 9(1):563-566, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Feng Z; Zhu L; Wu J
+Authors Full Name
+ Feng, Ziqian; Zhu, Luochen; Wu, Jianbo.
+Institution
+ Feng, Ziqian. Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.
+ Feng, Ziqian. Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
+ Zhu, Luochen. Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.
+ Zhu, Luochen. Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
+ Wu, Jianbo. Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.
+ Wu, Jianbo. Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Diabetes Mellitus/et [Etiology]
+ *Diabetes Mellitus/me [Metabolism]
+ Disease Models, Animal
+ Disease Susceptibility
+ Humans
+ *Macrophages/me [Metabolism]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Receptor for Advanced Glycation End Products/me [Metabolism]
+ *Signal Transduction
+Keyword Heading
+ RAGE
+ diabetes
+ macrophage
+ obesity
+ white adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The advanced glycosylation end product receptor (RAGE) acts as a recognition receptor and interacts with different types of ligands that form and accumulate in the tissues and circulation, such as diabetes, inflammation, insulin resistance, and obesity. In these environments, RAGE is expressed on the surface of various cells associated with tissue disturbance. This review mainly summarizes the characteristics of RAGE-related signalling, with a particular emphasis on the role of RAGE in the development of obesity. We also briefly describe the phenotypes and characteristics of macrophages and focus on the role of adipose tissue macrophages (ATMs) and the regulatory mechanisms in obesity, diabetes, and other related metabolic diseases. Besides, we will also elaborate on the prospect of new strategies for treating diabetes and obesity-related metabolic diseases by inhibiting RAGE signalling and regulating ATMs recruitment and polarization.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Receptor for Advanced Glycation End Products).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f21623945.2020.1817278
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Feng&issn=2162-3945&title=Adipocyte&atitle=RAGE+signalling+in+obesity+and+diabetes%3A+focus+on+the+adipose+tissue+macrophage.&volume=9&issue=1&spage=563&epage=566&date=2020&doi=10.1080%2F21623945.2020.1817278&pmid=32892690&sid=OVID:medline
+
+<1197>
+Unique Identifier
+ 32892365
+Title
+ Circulating lipidomic alterations in obese and non-obese subjects with non-alcoholic fatty liver disease.
+Source
+ Alimentary Pharmacology & Therapeutics. 52(10):1603-1614, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jung Y; Lee MK; Puri P; Koo BK; Joo SK; Jang SY; Lee DH; Jung YJ; Kim BG; Lee KL; Park TS; Kang KT; Ryu DH; Kang SW; Kim D; Oh S; Kim W; Hwang GS
+Author NameID
+ Kim, Donghee; ORCID: https://orcid.org/0000-0003-1919-6800
+ Kim, Won; ORCID: https://orcid.org/0000-0002-2926-1007
+Authors Full Name
+ Jung, Youngae; Lee, Min Kyung; Puri, Puneet; Koo, Bo Kyung; Joo, Sae Kyung; Jang, Seo Young; Lee, Dong Hyeon; Jung, Yong Jin; Kim, Byeong Gwan; Lee, Kook Lae; Park, Tae-Sik; Kang, Ki-Tae; Ryu, Do Hyun; Kang, Sang Won; Kim, Donghee; Oh, Sohee; Kim, Won; Hwang, Geum-Sook.
+Institution
+ Jung, Youngae. Seoul, Republic of Korea.
+ Lee, Min Kyung. Seoul, Republic of Korea.
+ Puri, Puneet. Richmond, VA, USA.
+ Koo, Bo Kyung. Seoul, Republic of Korea.
+ Joo, Sae Kyung. Seoul, Republic of Korea.
+ Jang, Seo Young. Seoul, Republic of Korea.
+ Lee, Dong Hyeon. Seoul, Republic of Korea.
+ Jung, Yong Jin. Seoul, Republic of Korea.
+ Kim, Byeong Gwan. Seoul, Republic of Korea.
+ Lee, Kook Lae. Seoul, Republic of Korea.
+ Park, Tae-Sik. Seongnam, Republic of Korea.
+ Kang, Ki-Tae. Suwon, Republic of Korea.
+ Ryu, Do Hyun. Suwon, Republic of Korea.
+ Kang, Sang Won. Seoul, Republic of Korea.
+ Kim, Donghee. Stanford, CA, USA.
+ Oh, Sohee. Seoul, Republic of Korea.
+ Kim, Won. Seoul, Republic of Korea.
+ Hwang, Geum-Sook. Seoul, Republic of Korea.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ Humans
+ Insulin Resistance/ph [Physiology]
+ Lipidomics
+ Lipids/an [Analysis]
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+Abstract
+ BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects obese and non-obese individuals. However, mechanisms underlying non-obese non-alcoholic steatohepatitis (NASH) remain unclear.
+
+ AIMS: To attempt to identify metabolic perturbations associated with non-obese and obese NAFLD using a lipidomics approach.
+
+ METHODS: A cross-sectional analysis of 361 subjects with biopsy-proven NAFLD (157 NAFL and 138 NASH) and healthy controls (n = 66) was performed. Individuals were categorised as obese or non-obese based on the Asian cut-off for body mass index. Circulating lipidomic profiling of sera was performed based on the histological severity of NAFLD. Circulating lipidomic alterations were validated with an independent validation set (154 NAFLD subjects [93 NAFL and 61 NASH] and 21 healthy controls).
+
+ RESULTS: Saturated sphingomyelin (SM) species were significantly associated with visceral adiposity in non-obese NAFLD (SM d38:0; P < 0.001) but not in obese NAFLD. Additionally, SM levels were significantly associated with systemic and adipose tissue insulin resistance (SM d38:0; P = 0.002 and <0.001, respectively). Five potential lipid metabolites for non-obese subjects and seven potential lipids for obese subjects were selected to predict NAFLD and NASH. These lipid combinations showed good diagnostic performance for non-obese (area under the curve [AUC] for NAFLD/NASH = 0.916/0.813) and obese (AUC for NAFLD/NASH = 0.967/0.812) subjects. Moreover, distinctly altered patterns of diacylglycerol (DAG), triacylglycerol (TAG) and SM levels were confirmed in the validation set depending on the histological severity of NAFLD.
+
+ CONCLUSION: Non-obese and obese NAFLD subjects exhibit unique circulating lipidomic signatures, including DAGs, TAGs and SMs. These lipid combinations may be useful biomarkers for non-obese and obese NAFLD patients. Copyright © 2020 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fapt.16066
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jung&issn=0269-2813&title=Alimentary+Pharmacology+%26+Therapeutics&atitle=Circulating+lipidomic+alterations+in+obese+and+non-obese+subjects+with+non-alcoholic+fatty+liver+disease.&volume=52&issue=10&spage=1603&epage=1614&date=2020&doi=10.1111%2Fapt.16066&pmid=32892365&sid=OVID:medline
+
+<1198>
+Unique Identifier
+ 32888612
+Title
+ Gut microbiota health closely associates with PCB153-derived risk of host diseases.
+Source
+ Ecotoxicology & Environmental Safety. 203:111041, 2020 Oct 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Min L; Chi Y; Dong S
+Authors Full Name
+ Min, Lingli; Chi, Yulang; Dong, Sijun.
+Institution
+ Min, Lingli. School of Resources and Environmental Science, Quanzhou Normal University, Quanzhou, China. Electronic address: llmin@qztc.edu.cn.
+ Chi, Yulang. College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, China. Electronic address: ylchi@qztc.edu.cn.
+ Dong, Sijun. Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China. Electronic address: sjdong@iue.ac.cn.
+MeSH Subject Headings
+ Animals
+ Biomarkers/an [Analysis]
+ Colon/mi [Microbiology]
+ *Dyslipidemias/ci [Chemically Induced]
+ Dyslipidemias/me [Metabolism]
+ Dyslipidemias/mi [Microbiology]
+ *Environmental Monitoring/mt [Methods]
+ *Environmental Pollutants/to [Toxicity]
+ Female
+ Gastrointestinal Contents/mi [Microbiology]
+ *Gastrointestinal Microbiome/de [Drug Effects]
+ Gastrointestinal Microbiome/ge [Genetics]
+ Gene Expression/de [Drug Effects]
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Mice
+ Mice, Inbred C57BL
+ *Obesity/ci [Chemically Induced]
+ Obesity/me [Metabolism]
+ Obesity/mi [Microbiology]
+ *Polychlorinated Biphenyls/to [Toxicity]
+ RNA, Ribosomal, 16S
+Keyword Heading
+ Dyslipidemia
+ Gut microbiota health
+ Host health
+ Lipid accumulation
+ PCB153
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Although the production and use of PCB153 have been banned globally, PCB153 pollution remains because of its persistence and long half-life in the environment. There is ongoing evidence that exposure to PCB153 may influence gut microbiota health and increase the risk of host health. It is needed to illuminate whether there are associations between gut microbiota dysregulation and PCB153-induced host diseases. Importantly, it is urgently needed to find specific strains as biomarkers to monitor PCB153 pollution and associated disorders. The work aims to investigate the change of gut microbiota composition, structure and diversity and various host physiological indexes, to ravel the chain causality of PCB153, gut microbiota health and host health, and to find potential gut microbiota markers for PCB153 pollution. Here, adult female mice were administrated with PCB153. Obtained results indicated that PCB153 led to gut microbiota health deterioration. PCB153 exposure also induced obesity, hepatic lipid accumulation, abdominal adipose tissue depots and dyslipidemia in mice. Furthermore, specific gut microbiota significantly correlated with the host health indexes. This work provides support for the relationship between gut microbiota aberrance derived from PCB153 and risk of host health, and offers some indications of possible indicative functions of gut microbiota on PCB153 pollution. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Environmental Pollutants). 0 (RNA, Ribosomal, 16S). DFC2HB4I0K (Polychlorinated Biphenyls). ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.ecoenv.2020.111041
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Min&issn=0147-6513&title=Ecotoxicology+%26+Environmental+Safety&atitle=Gut+microbiota+health+closely+associates+with+PCB153-derived+risk+of+host+diseases.&volume=203&issue=&spage=111041&epage=&date=2020&doi=10.1016%2Fj.ecoenv.2020.111041&pmid=32888612&sid=OVID:medline
+
+<1199>
+Unique Identifier
+ 32886125
+Title
+ Distinct Effects of Milk-Derived and Fermented Dairy Protein on Gut Microbiota and Cardiometabolic Markers in Diet-Induced Obese Mice.
+Source
+ Journal of Nutrition. 150(10):2673-2686, 2020 10 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Perazza LR; Daniel N; Dubois MJ; Pilon G; Varin TV; Blais M; Martinez Gonzales JL; Bouchard M; Asselin C; Lessard M; Pouliot Y; Roy D; Marette A
+Authors Full Name
+ Perazza, Lais Rossi; Daniel, Noemie; Dubois, Marie-Julie; Pilon, Genevieve; Varin, Thibault Vincent; Blais, Mylene; Martinez Gonzales, Jose Luis; Bouchard, Michael; Asselin, Claude; Lessard, Martin; Pouliot, Yves; Roy, Denis; Marette, Andre.
+Institution
+ Perazza, Lais Rossi. Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
+ Perazza, Lais Rossi. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+ Daniel, Noemie. Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
+ Daniel, Noemie. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+ Dubois, Marie-Julie. Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
+ Dubois, Marie-Julie. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+ Pilon, Genevieve. Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
+ Pilon, Genevieve. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+ Varin, Thibault Vincent. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+ Blais, Mylene. Sherbrooke R & D Center, Agriculture and Agri-Food Canada, Sherbrooke, Quebec, Canada.
+ Martinez Gonzales, Jose Luis. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+ Bouchard, Michael. Sherbrooke R & D Center, Agriculture and Agri-Food Canada, Sherbrooke, Quebec, Canada.
+ Asselin, Claude. Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, Quebec, Canada.
+ Lessard, Martin. Sherbrooke R & D Center, Agriculture and Agri-Food Canada, Sherbrooke, Quebec, Canada.
+ Pouliot, Yves. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+ Roy, Denis. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+ Marette, Andre. Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
+ Marette, Andre. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
+MeSH Subject Headings
+ Animals
+ Apolipoproteins B/ge [Genetics]
+ Apolipoproteins B/me [Metabolism]
+ Bacteria/cl [Classification]
+ Bacteria/de [Drug Effects]
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ *Cultured Milk Products/an [Analysis]
+ Diet
+ Diet, High-Fat
+ Dietary Sucrose/ad [Administration & Dosage]
+ *Gastrointestinal Microbiome/de [Drug Effects]
+ Gene Expression Regulation/de [Drug Effects]
+ Male
+ *Metabolic Diseases/pc [Prevention & Control]
+ Mice
+ Mice, Knockout
+ Milk/ch [Chemistry]
+ Milk Proteins/ch [Chemistry]
+ *Milk Proteins/pd [Pharmacology]
+ *Obesity/ci [Chemically Induced]
+ Receptors, LDL/ge [Genetics]
+ Receptors, LDL/me [Metabolism]
+Keyword Heading
+ bacteria
+ dairy products
+ fermentation
+ gut inflammation
+ peptides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Recent meta-analyses suggest that the consumption of fermented dairy products reduces type 2 diabetes and cardiovascular disease (CVD) risk, although the underlying mechanisms remain unclear.
+
+ OBJECTIVE: We evaluated whether dairy protein products modulated gut microbiota and cardiometabolic features in mouse models of diet-induced obesity and CVD.
+
+ METHODS: Eight-week-old C57BL/6J wild-type (WT) and LDLr-/-ApoB100/100 (LRKO) male mice were fed for 12 and 24 wk, respectively, with a high-fat/high-sucrose diet [66% kcal lipids, 22% kcal carbohydrates (100% sucrose), 12% kcal proteins]. The protein sources of the 4 diets were 100% nondairy protein (NDP), or 50% of the NDP energy replaced by milk (MP), milk fermented by Lactobacillus helveticus (FMP), or Greek-style yogurt (YP) protein. Fecal 16S rRNA gene-based amplicon sequencing, intestinal gene expression, and glucose tolerance test were conducted. Hepatic inflammation and circulating adhesion molecules were measured by multiplex assays.
+
+ RESULTS: Feeding WT mice for 12 wk led to a 74% increase in body weight, whereas after 24 wk the LRKO mice had a 101.5% increase compared with initial body weight. Compared with NDP and MP, the consumption of FMP and YP modulated the gut microbiota composition in a similar clustering pattern, upregulating the Streptococcus genus in both genotypes. In WT mice, feeding YP compared with NDP increased the expression of genes involved in jejunal (Reg3b, 7.3-fold, P = 0.049) and ileal (Ocln, 1.7-fold, P = 0.047; Il1-beta,1.7-fold, P = 0.038; Nos2, 3.8-fold, P = 0.018) immunity and integrity. In LRKO mice, feeding YP compared with MP improved insulin sensitivity by 65% (P = 0.039). In LRKO mice, feeding with FMP versus NDP attenuated hepatic inflammation (monocyte chemoattractant protein 1, 2.1-fold, P < 0.0001; IL1-beta, 5.7-fold, P = 0.0003; INF-gamma, 1.7-fold, P = 0.002) whereas both FMP [vascular adhesion molecule 1 (VCAM1), 1.3-fold, P = 0.0003] and YP (VCAM1, 1.04-fold, P = 0.013; intracellular adhesion molecule 1, 1.4-fold, P = 0.028) decreased circulating adhesion molecules.
+
+ CONCLUSION: Both fermented dairy protein products reduce cardiometabolic risk factors in diet-induced obese mice, possibly by modulating the gut microbiota. Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.
+Registry Number/Name of Substance
+ 0 (Apolipoproteins B). 0 (Biomarkers). 0 (Dietary Sucrose). 0 (Milk Proteins). 0 (Receptors, LDL).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1093%2fjn%2fnxaa217
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Perazza&issn=0022-3166&title=Journal+of+Nutrition&atitle=Distinct+Effects+of+Milk-Derived+and+Fermented+Dairy+Protein+on+Gut+Microbiota+and+Cardiometabolic+Markers+in+Diet-Induced+Obese+Mice.&volume=150&issue=10&spage=2673&epage=2686&date=2020&doi=10.1093%2Fjn%2Fnxaa217&pmid=32886125&sid=OVID:medline
+
+<1200>
+Unique Identifier
+ 32883688
+Title
+ Effect of diabetes on exosomal miRNA profile in patients with obesity.
+Source
+ BMJ Open Diabetes Research & Care. 8(1), 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim H; Bae YU; Lee H; Kim H; Jeon JS; Noh H; Han DC; Byun DW; Kim SH; Park HK; Ryu S; Kwon SH
+Author NameID
+ Kim, Hyoungnae; ORCID: https://orcid.org/0000-0002-5359-0214
+ Kwon, Soon Hyo; ORCID: https://orcid.org/0000-0002-4114-4196
+Authors Full Name
+ Kim, Hyoshik; Bae, Yun-Ui; Lee, Haekyung; Kim, Hyoungnae; Jeon, Jin Seok; Noh, Hyunjin; Han, Dong Cheol; Byun, Dong Won; Kim, Sang Hyun; Park, Hyeong Kyu; Ryu, Seongho; Kwon, Soon Hyo.
+Institution
+ Kim, Hyoshik. Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Bae, Yun-Ui. Department of Clinical Endocrinology and Metabolism, Keimyung University School of Medicine, Daegu, Kyungsang buk do, The Republic of Korea.
+ Lee, Haekyung. Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Kim, Hyoungnae. Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Kim, Hyoungnae. Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Jeon, Jin Seok. Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Jeon, Jin Seok. Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Noh, Hyunjin. Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Noh, Hyunjin. Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Han, Dong Cheol. Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Han, Dong Cheol. Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Byun, Dong Won. Division of Endocrinology and Metabolism, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Kim, Sang Hyun. Department of Surgery, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Park, Hyeong Kyu. Division of Endocrinology and Metabolism, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+ Ryu, Seongho. Soonchunhyang Institute of Med-bio Science (SIMS), Soonchunhyang University, Asan, Chungcheongnam-do, The Republic of Korea ksoonhyo@schmc.ac.kr ryu@sch.ac.kr.
+ Kwon, Soon Hyo. Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea ksoonhyo@schmc.ac.kr ryu@sch.ac.kr.
+ Kwon, Soon Hyo. Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, Seoul, The Republic of Korea.
+MeSH Subject Headings
+ Biomarkers
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Diabetes Mellitus, Type 2
+ Humans
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs
+ Obesity/ge [Genetics]
+ Prospective Studies
+Keyword Heading
+ biomarkers
+ diabetes mellitus
+ genetic
+ obesity
+ transcription
+ type 2
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity is a risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease. T2DM increases the risk of cardiovascular-related death. We investigated changes in circulating exosomal microRNA (miRNA) profiles in patients with DM with obesity compared with patients without DM with obesity.
+
+ RESEARCH DESIGN AND METHODS: This prospective study involved 29 patients with obesity (patients without DM=16, patients with DM=13) and healthy volunteers (HVs) (n=18). We measured circulating levels of exosomal miRNAs by next-generation sequencing and compared miRNA levels across the three groups.
+
+ RESULTS: The expression levels of 25 miRNAs (upregulated=14, downregulated=11) differed between patients with obesity with DM and patients with obesity without DM. Compared with HV, patients with DM with obesity had 53 dysregulated miRNAs. Additionally, moving stepwise from HV to patients with obesity without DM to patients with obesity with DM, there was a consistent increase in expression levels of miR-23a-5p and miR-6087 and a consistent decrease in expressions levels of miR-6751-3p.
+
+ CONCLUSIONS: Our data show that the exosomal miRNAs is altered by dysregulated glucose metabolism in patients with obesity. This circulating exosomal miRNA signature in patients with obesity with or without DM is a potential biomarker and therapeutic target in these patients. Copyright © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1136%2fbmjdrc-2020-001403
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=2052-4897&title=BMJ+Open+Diabetes+Research+%26+Care&atitle=Effect+of+diabetes+on+exosomal+miRNA+profile+in+patients+with+obesity.&volume=8&issue=1&spage=&epage=&date=2020&doi=10.1136%2Fbmjdrc-2020-001403&pmid=32883688&sid=OVID:medline
+
+<1201>
+Unique Identifier
+ 32881912
+Title
+ Feasibility of quantifying change in immune white cells in abdominal adipose tissue in response to an immune modulator in clinical obesity.
+Source
+ PLoS ONE [Electronic Resource]. 15(9):e0237496, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sattler FR; Mert M; Sankaranarayanan I; Mack WJ; Galle-Treger L; Gonzalez E; Baronikian L; Lee K; Jahani PS; Hodis HN; Dieli-Conwright C; Akbari O
+Author NameID
+ Sattler, Fred R; ORCID: https://orcid.org/0000-0002-1986-6803
+Authors Full Name
+ Sattler, Fred R; Mert, Melissa; Sankaranarayanan, Ishwarya; Mack, Wendy J; Galle-Treger, Lauriane; Gonzalez, Evelyn; Baronikian, Lilit; Lee, Kyuwan; Jahani, Pedram Shafiei; Hodis, Howard N; Dieli-Conwright, Christina; Akbari, Omid.
+Institution
+ Sattler, Fred R. Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Mert, Melissa. Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Sankaranarayanan, Ishwarya. Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Mack, Wendy J. Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Galle-Treger, Lauriane. Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Gonzalez, Evelyn. Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Baronikian, Lilit. Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Lee, Kyuwan. Ostrow School of Dentistry, Division of Physical Therapy and Biokinesiology, University of Southern California, Los Angeles, California, United States of America.
+ Lee, Kyuwan. Department of Population Sciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America.
+ Jahani, Pedram Shafiei. Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Hodis, Howard N. Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+ Dieli-Conwright, Christina. Ostrow School of Dentistry, Division of Physical Therapy and Biokinesiology, University of Southern California, Los Angeles, California, United States of America.
+ Akbari, Omid. Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.
+MeSH Subject Headings
+ *Abdominal Fat/pa [Pathology]
+ Adult
+ Biomarkers/bl [Blood]
+ Feasibility Studies
+ Female
+ Flow Cytometry
+ Humans
+ *Immunity, Innate
+ *Leukocytes, Mononuclear/pa [Pathology]
+ Lymphocytes/pa [Pathology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/im [Immunology]
+ Sitagliptin Phosphate/pd [Pharmacology]
+ Treatment Outcome
+Abstract
+ BACKGROUND: Obesity is often associated with inflammation in adipose tissue (AT) with release of mediators of atherogenesis. We postulated that it would be feasible to collect sufficient abdominal AT to quantify changes in a broad array of adaptive and innate mononuclear white cells in obese non-diabetic adults in response to a dipeptidyl protease inhibitor (DPP4i), known to inhibit activation of immune white cells.
+
+ METHODS: Adults 18-55 years-of-age were screened for abdominal obesity and insulin resistance or impaired glucose tolerance but without known inflammatory conditions. Twenty-one eligible participants consented for study and were randomized 3:1 to receive sitagliptin (DPP4i) at 100mg or matching placebo daily for 28 days. Abdominal AT collected by percutaneous biopsy and peripheral blood mononuclear cell fractions were evaluated before and after treatment; plasma was stored for batch testing.
+
+ RESULTS: Highly sensitive C-reactive protein, a global marker of inflammation, was not elevated in the study population. Innate lymphoid cells (ILC) type 3 (ILC-3) in abdominal AT decreased with active treatment compared with placebo (p = 0.04). Other immune white cells in AT and peripheral blood mononuclear cell (PBMC) fractions did not change with treatment compared to placebo (p>0.05); although ILC-2 declined in PBMCs (p = 0.007) in the sitagliptin treatment group. Two circulating biomarkers of atherogenesis, interferon-inducible protein-10 (IP-10) and sCD40L declined in plasma (p = 0.02 and p = 0.07, respectively) in the active treatment group, providing indirect validation of a net reduction in inflammation.
+
+ CONCLUSIONS: In this pilot study, two cell types of the innate lymphoid system, ILC-3 in AT and ILC-2 PBMCs declined during treatment and as did circulating biomarkers of atherogenesis. Changes in other immune cells were not demonstrable. The study showed that sufficient abdominal AT could be obtained to quantify white cells of both innate and adaptive immunity and to demonstrate changes during therapy with an immune inhibitor.
+
+ TRIAL REGISTRATION: ClinicalTrials.gov identifier (NCT number): NCT02576.
+Registry Number/Name of Substance
+ 0 (Biomarkers). TS63EW8X6F (Sitagliptin Phosphate).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0237496
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sattler&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Feasibility+of+quantifying+change+in+immune+white+cells+in+abdominal+adipose+tissue+in+response+to+an+immune+modulator+in+clinical+obesity.&volume=15&issue=9&spage=e0237496&epage=&date=2020&doi=10.1371%2Fjournal.pone.0237496&pmid=32881912&sid=OVID:medline
+
+<1202>
+Unique Identifier
+ 32873589
+Title
+ Dietary Inflammatory and Insulinemic Potential and Risk of Type 2 Diabetes: Results From Three Prospective U.S. Cohort Studies.
+Source
+ Diabetes Care. 43(11):2675-2683, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee DH; Li J; Li Y; Liu G; Wu K; Bhupathiraju S; Rimm EB; Rexrode KM; Manson JE; Willett WC; Hu FB; Tabung FK; Giovannucci EL
+Author NameID
+ Lee, Dong Hoon; ORCID: https://orcid.org/0000-0003-1329-4637
+ Li, Jun; ORCID: https://orcid.org/0000-0003-3519-8638
+ Li, Yanping; ORCID: https://orcid.org/0000-0002-0412-2748
+ Liu, Gang; ORCID: https://orcid.org/0000-0002-1430-3016
+ Bhupathiraju, Shilpa; ORCID: https://orcid.org/0000-0001-9910-6777
+Authors Full Name
+ Lee, Dong Hoon; Li, Jun; Li, Yanping; Liu, Gang; Wu, Kana; Bhupathiraju, Shilpa; Rimm, Eric B; Rexrode, Kathryn M; Manson, JoAnn E; Willett, Walter C; Hu, Frank B; Tabung, Fred K; Giovannucci, Edward L.
+Institution
+ Lee, Dong Hoon. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA dhlee@mail.harvard.edu.
+ Li, Jun. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Li, Jun. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Li, Yanping. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Liu, Gang. Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
+ Wu, Kana. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Bhupathiraju, Shilpa. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Bhupathiraju, Shilpa. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Rimm, Eric B. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Rimm, Eric B. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Rimm, Eric B. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
+ Rexrode, Kathryn M. Division of Women's Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
+ Manson, JoAnn E. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Manson, JoAnn E. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
+ Manson, JoAnn E. Mary Horrigan Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
+ Willett, Walter C. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Willett, Walter C. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Willett, Walter C. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
+ Hu, Frank B. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Hu, Frank B. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Hu, Frank B. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
+ Tabung, Fred K. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Tabung, Fred K. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Tabung, Fred K. Division of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH.
+ Giovannucci, Edward L. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Giovannucci, Edward L. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Giovannucci, Edward L. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ C-Peptide/bl [Blood]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ *Diet/ae [Adverse Effects]
+ Female
+ Follow-Up Studies
+ *Food/ae [Adverse Effects]
+ Humans
+ *Hyperinsulinism/co [Complications]
+ Incidence
+ Inflammation/co [Complications]
+ Male
+ Middle Aged
+ Nurses
+ Obesity/co [Complications]
+ Proportional Hazards Models
+ Prospective Studies
+ Risk
+ Self Report
+ United States/ep [Epidemiology]
+Abstract
+ OBJECTIVE: To examine whether proinflammatory and hyperinsulinemic diets are associated with increased risk of type 2 diabetes.
+
+ RESEARCH DESIGN AND METHODS: We prospectively followed 74,767 women from the Nurses' Health Study (1984-2016), 90,786 women from the Nurses' Health Study II (1989-2017), and 39,442 men from the Health Professionals Follow-up Study (1986-2016). Using repeated measures of food-frequency questionnaires, we calculated empirical dietary inflammatory pattern (EDIP) and empirical dietary index for hyperinsulinemia (EDIH) scores, which are food-based indices that characterize dietary inflammatory or insulinemic potential based on circulating biomarkers of inflammation or C-peptide. Diagnoses of type 2 diabetes were confirmed by validated supplementary questionnaires.
+
+ RESULTS: We documented 19,666 incident type 2 diabetes cases over 4.9 million person-years of follow-up. In the pooled multivariable-adjusted analyses, individuals in the highest EDIP or EDIH quintile had 3.11 times (95% CI 2.96-3.27) and 3.40 times (95% CI 3.23-3.58) higher type 2 diabetes risk, respectively, compared with those in the lowest quintile. Additional adjustment for BMI attenuated the associations (hazard ratio 1.95 [95% CI 1.85-2.05] for EDIP and hazard ratio 1.87 [95% CI 1.78-1.98] for EDIH), suggesting adiposity partly mediates the observed associations. Moreover, individuals in both highest EDIP and EDIH quintiles had 2.34 times higher type 2 diabetes risk (95% CI 2.17-2.52), compared with those in both lowest quintiles, after adjustment for BMI.
+
+ CONCLUSIONS: Higher dietary inflammatory and insulinemic potential were associated with increased type 2 diabetes incidence. Findings suggest that inflammation and hyperinsulinemia are potential mechanisms linking dietary patterns and type 2 diabetes development. Copyright © 2020 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C-Peptide).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2337%2fdc20-0815
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=0149-5992&title=Diabetes+Care&atitle=Dietary+Inflammatory+and+Insulinemic+Potential+and+Risk+of+Type+2+Diabetes%3A+Results+From+Three+Prospective+U.S.+Cohort+Studies.&volume=43&issue=11&spage=2675&epage=2683&date=2020&doi=10.2337%2Fdc20-0815&pmid=32873589&sid=OVID:medline
+
+<1203>
+Unique Identifier
+ 32872122
+Title
+ Significantly Elevated Levels of Plasma Nicotinamide, Pyridoxal, and Pyridoxamine Phosphate Levels in Obese Emirati Population: A Cross-Sectional Study.
+Source
+ Molecules. 25(17), 2020 Aug 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ibrahim GR; Shah I; Gariballa S; Yasin J; Barker J; Salman Ashraf S
+Author NameID
+ Shah, Iltaf; ORCID: https://orcid.org/0000-0002-3739-6083
+ Gariballa, Salah; ORCID: https://orcid.org/0000-0002-0069-6322
+ Barker, James; ORCID: https://orcid.org/0000-0002-5863-9400
+ Salman Ashraf, Syed; ORCID: https://orcid.org/0000-0003-4961-5527
+Authors Full Name
+ Ibrahim, Ghada Rashad; Shah, Iltaf; Gariballa, Salah; Yasin, Javed; Barker, James; Salman Ashraf, Syed.
+Institution
+ Ibrahim, Ghada Rashad. Department of Chemistry, College of Science, UAE University, P.O. Box 15551, Al Ain, UAE.
+ Shah, Iltaf. Department of Chemistry, College of Science, UAE University, P.O. Box 15551, Al Ain, UAE.
+ Gariballa, Salah. Department of Internal Medicine, College of Medicine, UAE University, P.O. Box 15551, Al Ain, UAE.
+ Yasin, Javed. Department of Internal Medicine, College of Medicine, UAE University, P.O. Box 15551, Al Ain, UAE.
+ Barker, James. Department of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK.
+ Salman Ashraf, Syed. Department of Chemistry, College of Arts and Sciences, Khalifa University, P.O. Box 127788, Abu Dhabi, UAE.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers
+ Chromatography, Liquid
+ Cross-Sectional Studies
+ Female
+ Humans
+ Male
+ Mass Spectrometry
+ Middle Aged
+ *Niacinamide/bl [Blood]
+ *Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Public Health Surveillance
+ *Pyridoxal/bl [Blood]
+ *Pyridoxamine/aa [Analogs & Derivatives]
+ Pyridoxamine/bl [Blood]
+ Sensitivity and Specificity
+ Young Adult
+Keyword Heading
+ Emirati population
+ bioanalytical quantification
+ obesity
+ serum
+ vitamins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Water-soluble vitamins like B3 (nicotinamide), B6 (pyridoxine), and B9 (folic acid) are of utmost importance in human health and disease, as they are involved in numerous critical metabolic reactions. Not surprisingly, deficiencies of these vitamins have been linked to various disease states. Unfortunately, not much is known about the physiological levels of B6 vitamers and vitamin B3 in an ethnically isolated group (such as an Emirati population), as well as their relationship with obesity. The aim of the present study was to quantify various B6 vitamers, as well as B3, in the plasma of obese and healthy Emirati populations and to examine their correlation with obesity. A sensitive and robust HPLC-MS/MS-based method was developed for the simultaneous quantitation of five physiologically relevant forms of vitamin B6, namely pyridoxal, pyridoxine, pyridoxamine, pyridoxamine phosphate, and pyridoxal phosphate, as well as nicotinamide, in human plasma. This method was used to quantify the concentrations of these vitamers in the plasma of 57 healthy and 57 obese Emirati volunteers. Our analysis showed that the plasma concentrations of nicotinamide, pyridoxal, and pyridoxamine phosphate in the obese Emirati population were significantly higher than those in healthy volunteers (p < 0.0001, p = 0.0006, and p = 0.002, respectively). No significant differences were observed for the plasma concentrations of pyridoxine and pyridoxal phosphate. Furthermore, the concentrations of some of these vitamers in healthy Emirati volunteers were significantly different than those published in the literature for Western populations, such as American and European volunteers. This initial study underscores the need to quantify micronutrients in distinct ethnic groups, as well as people suffering from chronic metabolic disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 25X51I8RD4 (Niacinamide). 3THM379K8A (Pyridoxal). 6466NM3W93 (Pyridoxamine). QWW7V29814 (pyridoxamine phosphate).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fmolecules25173932
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ibrahim&issn=1420-3049&title=Molecules&atitle=Significantly+Elevated+Levels+of+Plasma+Nicotinamide%2C+Pyridoxal%2C+and+Pyridoxamine+Phosphate+Levels+in+Obese+Emirati+Population%3A+A+Cross-Sectional+Study.&volume=25&issue=17&spage=3932&epage=&date=2020&doi=10.3390%2Fmolecules25173932&pmid=32872122&sid=OVID:medline
+
+<1204>
+Unique Identifier
+ 32863171
+Title
+ Associations of GlycA and high-sensitivity C-reactive protein with measures of lipolysis in adults with obesity.
+Source
+ Journal of Clinical Lipidology. 14(5):667-674, 2020 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Levine JA; Han JM; Wolska A; Wilson SR; Patel TP; Remaley AT; Periwal V; Yanovski JA; Demidowich AP
+Authors Full Name
+ Levine, Jordan A; Han, Jung Min; Wolska, Anna; Wilson, Sierra R; Patel, Tushar P; Remaley, Alan T; Periwal, Vipul; Yanovski, Jack A; Demidowich, Andrew P.
+Institution
+ Levine, Jordan A. Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
+ Han, Jung Min. Computational Medicine Section, Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
+ Wolska, Anna. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
+ Wilson, Sierra R. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
+ Patel, Tushar P. Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
+ Remaley, Alan T. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
+ Periwal, Vipul. Computational Medicine Section, Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
+ Yanovski, Jack A. Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
+ Demidowich, Andrew P. Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA; Johns Hopkins Community Physicians at Howard County General Hospital, Johns Hopkins Medicine, Columbia, MD, USA; Department of Endocrinology, Diabetes and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: ademido1@jh.edu.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ *Blood Glucose/me [Metabolism]
+ *C-Reactive Protein/me [Metabolism]
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ *Glycine Hydroxymethyltransferase/me [Metabolism]
+ *Glycoproteins/me [Metabolism]
+ Humans
+ Inflammation
+ Lipolysis
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/me [Metabolism]
+ Randomized Controlled Trials as Topic
+Keyword Heading
+ Adipose tissue
+ GlycA
+ Inflammation
+ Insulin resistance
+ Lipolysis
+ hsCRP
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity-associated inflammation promotes metabolic dysfunction. However, it is unclear how different inflammatory biomarkers predict dysregulation in specific tissues/organs, particularly adipose tissue.
+
+ OBJECTIVE: The aim of our study was to examine whether GlycA, a nuclear magnetic resonance-measured biomarker of inflammation, is a better predictor of insulin-suppressible lipolysis and other measures of metabolic dysfunction compared with high-sensitivity C-reactive protein (hsCRP) in human obesity.
+
+ METHODS: This was a cross-sectional study of 58 nondiabetic adults with obesity (body mass index: 39.8 +/- 7.0 kg/m2, age 46.5 +/- 12.2 years, 67.2% female) who underwent a frequently sampled intravenous glucose tolerance test in the fasted state. Noninsulin-suppressible (l0), insulin-suppressible (l2), and maximal (l0+l2) lipolysis rates, as well as insulin sensitivity and acute insulin response to glucose, were calculated by minimal model analysis. Nuclear magnetic resonance was used to measure GlycA. Body composition was determined by dual-energy X-ray absorptiometry.
+
+ RESULTS: GlycA was strongly correlated with hsCRP (r = +0.46; P < .001). GlycA and hsCRP were positively associated with l2, l0+l2, and fat mass (Ps < .01). In linear regression models accounting for age, race, sex, and fat mass, GlycA remained significantly associated with l2 and l0+l2 (Ps < .05), whereas hsCRP did not (Ps >= .20). Neither GlycA nor hsCRP was associated with l0, insulin sensitivity, or acute insulin response to glucose.
+
+ CONCLUSIONS: GlycA was associated with elevated lipolysis, independent of adiposity, in adults with obesity. Our findings suggest that GlycA and hsCRP have distinct inflammation-mediated metabolic effects, with GlycA having a greater association with adipose tissue dysfunction. Further studies are warranted to investigate the mechanisms underlying these associations. Copyright Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycoproteins). 9007-41-4 (C-Reactive Protein). EC 2-1-2-1 (Glycine Hydroxymethyltransferase).
+Publication Type
+ Journal Article. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.jacl.2020.07.012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Levine&issn=1933-2874&title=Journal+of+Clinical+Lipidology&atitle=Associations+of+GlycA+and+high-sensitivity+C-reactive+protein+with+measures+of+lipolysis+in+adults+with+obesity.&volume=14&issue=5&spage=667&epage=674&date=2020&doi=10.1016%2Fj.jacl.2020.07.012&pmid=32863171&sid=OVID:medline
+
+<1205>
+Unique Identifier
+ 32861147
+Title
+ Association of 25-hydroxyvitamin D levels and metabolic syndrome in Thai postmenopausal women.
+Source
+ Diabetes & Metabolic Syndrome. 14(6):1585-1590, 2020 Nov-Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jeenduang N; Plyduang T; Horpet D
+Authors Full Name
+ Jeenduang, Nutjaree; Plyduang, Thunyaluk; Horpet, Dararat.
+Institution
+ Jeenduang, Nutjaree. School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand. Electronic address: nutjaree.je@wu.ac.th.
+ Plyduang, Thunyaluk. Center for Scientific and Technological Equipments, Walailak University, Nakhon Si Thammarat, Thailand.
+ Horpet, Dararat. Center for Scientific and Technological Equipments, Walailak University, Nakhon Si Thammarat, Thailand.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Hypertriglyceridemia/pp [Physiopathology]
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/et [Etiology]
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Postmenopause
+ Prevalence
+ Prognosis
+ Risk Factors
+ Thailand/ep [Epidemiology]
+ *Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ *Vitamin D Deficiency/co [Complications]
+Keyword Heading
+ Metabolic syndrome
+ Postmenopause
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been reported to be associated with metabolic syndrome (MetS). In this study, we aimed to investigate the association between serum 25(OH)D levels and MetS in Thai postmenopausal women.
+
+ METHODS: A total of 340 postmenopausal women were enrolled in the study. The concentration of 25(OH)D, lipid profiles, fasting blood glucose (FBG) levels, blood pressure, and demographic and anthropometric parameters were measured. Subjects were divided into the hypovitaminosis D and vitamin D sufficiency groups. The association of serum 25(OH)D levels with MetS in postmenopausal women was analyzed using multivariate regression analysis.
+
+ RESULTS: Waist circumference, total cholesterol levels, and triglyceride levels were significantly higher in hypovitaminosis D than in vitamin D sufficiency (p < 0.05). The prevalence of MetS, central obesity, and hypertriglyceridemia in hypovitaminosis D was significantly higher than in vitamin D sufficiency (p < 0.05). In the multivariable logistic regression model, hypovitaminosis D was associated with MetS (OR 1.85; 95% CI 1.12-3.04, p = 0.015), central obesity (OR 2.41; 95% CI 1.20-4.85, p = 0.014), and hypertriglyceridemia (OR 1.91; 95% CI 1.12-3.26, p = 0.018) compared with vitamin D sufficiency after adjusting for covariates. Serum vitamin D concentrations were significantly lower in the MetS group than in the non-MetS group (p = 0.016) and decreased with an increasing number of MetS components (p for trend = 0.034).
+
+ CONCLUSIONS: Hypovitaminosis D was associated with an increased risk of MetS, central obesity, and hypertriglyceridemia in Thai postmenopausal women. Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1406-16-2 (Vitamin D). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.dsx.2020.08.018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jeenduang&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+of+25-hydroxyvitamin+D+levels+and+metabolic+syndrome+in+Thai+postmenopausal+women.&volume=14&issue=6&spage=1585&epage=1590&date=2020&doi=10.1016%2Fj.dsx.2020.08.018&pmid=32861147&sid=OVID:medline
+
+<1206>
+Unique Identifier
+ 32859990
+Title
+ Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice.
+Source
+ Communications Biology. 3(1):473, 2020 08 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sakayori N; Katakura M; Hamazaki K; Higuchi O; Fujii K; Fukabori R; Iguchi Y; Setogawa S; Takao K; Miyazawa T; Arita M; Kobayashi K
+Author NameID
+ Sakayori, Nobuyuki; ORCID: http://orcid.org/0000-0003-1611-4187
+ Katakura, Masanori; ORCID: http://orcid.org/0000-0002-2237-9651
+ Hamazaki, Kei; ORCID: http://orcid.org/0000-0003-0456-6805
+ Fukabori, Ryoji; ORCID: http://orcid.org/0000-0001-7534-8237
+ Iguchi, Yoshio; ORCID: http://orcid.org/0000-0001-8240-3345
+ Takao, Keizo; ORCID: http://orcid.org/0000-0002-4734-3583
+ Arita, Makoto; ORCID: http://orcid.org/0000-0001-9902-0463
+Authors Full Name
+ Sakayori, Nobuyuki; Katakura, Masanori; Hamazaki, Kei; Higuchi, Oki; Fujii, Kazuki; Fukabori, Ryoji; Iguchi, Yoshio; Setogawa, Susumu; Takao, Keizo; Miyazawa, Teruo; Arita, Makoto; Kobayashi, Kazuto.
+Institution
+ Sakayori, Nobuyuki. Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, 960-1295, Japan. sakayori@hiroshima-u.ac.jp.
+ Sakayori, Nobuyuki. Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, 102-0083, Japan. sakayori@hiroshima-u.ac.jp.
+ Sakayori, Nobuyuki. Department of Physiology and Oral Physiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan. sakayori@hiroshima-u.ac.jp.
+ Katakura, Masanori. Laboratory of Nutritional Physiology, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Sakado, Saitama, 350-0295, Japan.
+ Hamazaki, Kei. Department of Public Health, Faculty of Medicine, University of Toyama, Sugitani, Toyama, 930-0194, Japan.
+ Higuchi, Oki. New Industry Creation Hatchery Center, Tohoku University, Sendai, Miyagi, 980-8579, Japan.
+ Higuchi, Oki. Biodynamic Plant Institute Co., Ltd., Sapporo, Hokkaido, 001-0021, Japan.
+ Fujii, Kazuki. Department of Behavioral Physiology, Graduate School of Innovative Life Science, University of Toyama, Sugitani, Toyama, 930-0194, Japan.
+ Fujii, Kazuki. Life Science Research Center, University of Toyama, Sugitani, Toyama, 930-0194, Japan.
+ Fukabori, Ryoji. Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, 960-1295, Japan.
+ Iguchi, Yoshio. Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, 960-1295, Japan.
+ Setogawa, Susumu. Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, 960-1295, Japan.
+ Setogawa, Susumu. Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, 102-0083, Japan.
+ Setogawa, Susumu. Division for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Dokkyo Medical University, Mibu-machi, Tochigi, 321-0293, Japan.
+ Takao, Keizo. Department of Behavioral Physiology, Graduate School of Innovative Life Science, University of Toyama, Sugitani, Toyama, 930-0194, Japan.
+ Takao, Keizo. Life Science Research Center, University of Toyama, Sugitani, Toyama, 930-0194, Japan.
+ Miyazawa, Teruo. New Industry Creation Hatchery Center, Tohoku University, Sendai, Miyagi, 980-8579, Japan.
+ Arita, Makoto. Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
+ Arita, Makoto. Graduate School of Medical Life Science, Yokohama City University, Yokohama, Kanagawa, 230-0045, Japan.
+ Arita, Makoto. Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Minato-ku, Tokyo, 105-0011, Japan.
+ Kobayashi, Kazuto. Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, 960-1295, Japan.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Brain/me [Metabolism]
+ Brain/pp [Physiopathology]
+ *Diet
+ Disease Models, Animal
+ Disease Susceptibility
+ Dopamine/bi [Biosynthesis]
+ Dopaminergic Neurons/me [Metabolism]
+ *Fatty Acids, Omega-3/ad [Administration & Dosage]
+ *Fatty Acids, Omega-6/ad [Administration & Dosage]
+ *Feeding and Eating Disorders/et [Etiology]
+ Female
+ Fluorescent Antibody Technique
+ Hyperphagia
+ Lipid Metabolism
+ *Maternal Exposure/ae [Adverse Effects]
+ Mice
+ Mice, Knockout
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Pregnancy
+ *Prenatal Exposure Delayed Effects
+Abstract
+ The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and low in omega-3 (n-3) PUFAs (an n-6high/n-3low diet), whose n-6/n-3 ratio is approximately 120, induces hedonic consumption in the offspring by upregulating the midbrain dopaminergic system. We found that exposure to the n-6high/n-3low diet specifically increases the consumption of palatable foods via increased mesolimbic dopamine release. In addition, neurodevelopmental analyses revealed that this induced hedonic consumption is programmed during embryogenesis, as dopaminergic neurogenesis is increased during in utero access to the n-6high/n-3low diet. Our findings reveal that maternal consumption of PUFAs can have long-lasting effects on the offspring's pattern for consuming highly palatable foods.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Omega-3). 0 (Fatty Acids, Omega-6). VTD58H1Z2X (Dopamine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs42003-020-01209-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sakayori&issn=2399-3642&title=Communications+Biology&atitle=Maternal+dietary+imbalance+between+omega-6+and+omega-3+fatty+acids+triggers+the+offspring%27s+overeating+in+mice.&volume=3&issue=1&spage=473&epage=&date=2020&doi=10.1038%2Fs42003-020-01209-4&pmid=32859990&sid=OVID:medline
+
+<1207>
+Unique Identifier
+ 32858131
+Title
+ Interplay between oxidative damage, the redox status, and metabolic biomarkers during long-term fasting.
+Source
+ Food & Chemical Toxicology. 145:111701, 2020 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Grundler F; Mesnage R; Goutzourelas N; Tekos F; Makri S; Brack M; Kouretas D; Wilhelmi de Toledo F
+Authors Full Name
+ Grundler, Franziska; Mesnage, Robin; Goutzourelas, Nikolaos; Tekos, Fotios; Makri, Sotiria; Brack, Michel; Kouretas, Demetrios; Wilhelmi de Toledo, Francoise.
+Institution
+ Grundler, Franziska. Buchinger Wilhelmi Clinic, 88662, Uberlingen, Germany; Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin and Berlin Institute of Health, 10117, Berlin, Germany. Electronic address: franziska.grundler@buchinger-wilhelmi.com.
+ Mesnage, Robin. Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, 8th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK. Electronic address: robin.mesnage@kcl.ac.uk.
+ Goutzourelas, Nikolaos. Department of Biochemistry-Biotechnology, School of Health Sciences, University of Thessaly, Viopolis, 41500, Larissa, Greece. Electronic address: nikgkoutz@gmail.com.
+ Tekos, Fotios. Department of Biochemistry-Biotechnology, School of Health Sciences, University of Thessaly, Viopolis, 41500, Larissa, Greece. Electronic address: fotis.tekos@gmail.com.
+ Makri, Sotiria. Department of Biochemistry-Biotechnology, School of Health Sciences, University of Thessaly, Viopolis, 41500, Larissa, Greece. Electronic address: Sotirina_m@hotmail.com.
+ Brack, Michel. The Oxidative Stress College Paris, 75007, Paris, France. Electronic address: brackmichel@free.fr.
+ Kouretas, Demetrios. Department of Biochemistry-Biotechnology, School of Health Sciences, University of Thessaly, Viopolis, 41500, Larissa, Greece. Electronic address: dkouret@uth.gr.
+ Wilhelmi de Toledo, Francoise. Buchinger Wilhelmi Clinic, 88662, Uberlingen, Germany. Electronic address: francoise.wilhelmi@buchinger-wilhelmi.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ COVID-19
+ Coronavirus Infections/pc [Prevention & Control]
+ *Fasting/me [Metabolism]
+ Female
+ *Free Radical Scavengers/me [Metabolism]
+ Humans
+ Lipid Metabolism/ph [Physiology]
+ Lipid Peroxidation/ph [Physiology]
+ Machine Learning
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ *Oxidative Stress/ph [Physiology]
+ Pandemics/pc [Prevention & Control]
+ Pneumonia, Viral/pc [Prevention & Control]
+ Young Adult
+Keyword Heading
+ Antioxidant capacity
+ Dysmetabolism
+ Oxidative stress
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and its related metabolic disorders, as well as infectious diseases like covid-19, are important health risks nowadays. It was recently documented that long-term fasting improves metabolic health and enhanced the total antioxidant capacity. The present study investigated the influence of a 10-day fasting on markers of the redox status in 109 subjects. Reducing power, 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical cation(ABTS) radical scavenging capacity, and hydroxyl radical scavenging capacity increased significantly, and indicated an increase of circulating antioxidant levels. No differences were detected in superoxide scavenging capacity, protein carbonyls, and superoxide dismutase when measured at baseline and after 10 days of fasting. These findings were concomitant to a decrease in blood glucose, insulin, glycated hemoglobin (HbA1c), total cholesterol, low-density lipoprotein (LDL) and triglycerides as well as an increase in total cholesterol/high-density lipoprotein (HDL) ratio. In addition, the well-being index as well as the subjective energy levels increased, documenting a good tolerability. There was an interplay between redox and metabolic parameters since lipid peroxidation baseline levels (thiobarbituric acid reactive substances [TBARS]) affected the ability of long-term fasting to normalize lipid levels. A machine learning model showed that a combination of antioxidant parameters measured at baseline predicted the efficiency of the fasting regimen to decrease LDL levels. In conclusion, it was demonstrated that long-term fasting enhanced the endogenous production of antioxidant molecules, that act protectively against free radicals, and in parallel improved the metabolic health status. Our results suggest that the outcome of long-term fasting strategies could be depending on the baseline values of the antioxidative and metabolic status of subjects. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Free Radical Scavengers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.fct.2020.111701
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Grundler&issn=0278-6915&title=Food+%26+Chemical+Toxicology&atitle=Interplay+between+oxidative+damage%2C+the+redox+status%2C+and+metabolic+biomarkers+during+long-term+fasting.&volume=145&issue=&spage=111701&epage=&date=2020&doi=10.1016%2Fj.fct.2020.111701&pmid=32858131&sid=OVID:medline
+
+<1208>
+Unique Identifier
+ 32857714
+Title
+ Endocrine approach in the treatment of obesity: Is there any space for the adiponectin action?.
+Source
+ Endocrine Regulations. 54(3):157-159, 2020 Jul 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Michalakis KG
+Authors Full Name
+ Michalakis, Konstantinos G.
+Institution
+ Michalakis, Konstantinos G. Endocrine Practice, Division of Obesity, Athens, Greece.
+MeSH Subject Headings
+ Adiponectin/pd [Pharmacology]
+ *Adiponectin/ph [Physiology]
+ Adiponectin/tu [Therapeutic Use]
+ Anti-Obesity Agents/pd [Pharmacology]
+ *Anti-Obesity Agents/tu [Therapeutic Use]
+ Biomarkers/an [Analysis]
+ Depression/di [Diagnosis]
+ Depression/dt [Drug Therapy]
+ Endocrine System/de [Drug Effects]
+ Endocrine System/ph [Physiology]
+ Fertility Agents/pd [Pharmacology]
+ Fertility Agents/tu [Therapeutic Use]
+ Hormone Antagonists/pd [Pharmacology]
+ Hormone Antagonists/tu [Therapeutic Use]
+ Hormones/pd [Pharmacology]
+ *Hormones/tu [Therapeutic Use]
+ Humans
+ Insulin Resistance
+ Neoplasms/co [Complications]
+ Neoplasms/di [Diagnosis]
+ Neoplasms/th [Therapy]
+ *Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ Signal Transduction/de [Drug Effects]
+Keyword Heading
+ adiponectin
+ non metabolic actions
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adiponectin is a hormone secreted by adipose tissue, exerting many positive effects in the human body. Its action has been widely studied, placing it into the metabolic health beneficial products of the adipose tissue. Nevertheless, adiponectin has been shown to exert some extra beneficial non metabolic actions, as well. Adiponectin levels can be related to reduced incidence of cancer in obese patients. Moreover, adiponectin has been shown to be implicated in the positive fertility outcomes of women. Some new studies have also indicated that adiponectin has a potential effect in the control of appetite, which raises a question, whether adiponectin could be accredited to be useful in the endocrine evaluation of obesity. Could these additional non-metabolic actions prove its helpfulness?
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Fertility Agents). 0 (Hormone Antagonists). 0 (Hormones).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2478%2fenr-2020-0018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Michalakis&issn=1210-0668&title=Endocrine+Regulations&atitle=Endocrine+approach+in+the+treatment+of+obesity%3A+Is+there+any+space+for+the+adiponectin+action%3F.&volume=54&issue=3&spage=157&epage=159&date=2020&doi=10.2478%2Fenr-2020-0018&pmid=32857714&sid=OVID:medline
+
+<1209>
+Unique Identifier
+ 32854366
+Title
+ Changes in Lipoinflammation Markers in People with Obesity after a Concurrent Training Program: A Comparison between Men and Women.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 17(17), 2020 08 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gonzalez-Jurado JA; Suarez-Carmona W; Lopez S; Sanchez-Oliver AJ
+Author NameID
+ Gonzalez-Jurado, Jose Antonio; ORCID: https://orcid.org/0000-0003-2222-6089
+ Lopez, Sergio; ORCID: https://orcid.org/0000-0001-5952-3568
+ Sanchez-Oliver, Antonio Jesus; ORCID: https://orcid.org/0000-0001-9022-6043
+Authors Full Name
+ Gonzalez-Jurado, Jose Antonio; Suarez-Carmona, Walter; Lopez, Sergio; Sanchez-Oliver, Antonio Jesus.
+Institution
+ Gonzalez-Jurado, Jose Antonio. Facultad de Ciencias del Deporte; Universidad Pablo de Olavide de Sevilla, 41013 Sevilla, Spain.
+ Suarez-Carmona, Walter. Investigador Sistema de Informacion Cientifica de Andalucia, Universidad Pablo Olavide de Sevilla, 41013 Sevilla, Spain.
+ Lopez, Sergio. Laboratory of Cellular and Molecular Nutrition, Inst. de la Grasa, CSIC, 41013 Seville, Spain.
+ Lopez, Sergio. Department of Cell Biology, University of Seville, 41012 Seville, Spain.
+ Sanchez-Oliver, Antonio Jesus. Departamento de Motricidad Humana y Rendimiento Deportivo, Universidad de Sevilla, 41013 Sevilla, Spain.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Exercise
+ Exercise Therapy
+ Female
+ Humans
+ *Leptin/bl [Blood]
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/th [Therapy]
+ Reproducibility of Results
+ Sedentary Behavior
+ Sex Factors
+Keyword Heading
+ adiponectin
+ adiponectin-leptin ratio
+ leptin
+ overweight
+ physical exercise
+ sedentary lifestyle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is related to low-grade systemic inflammation. This state of inflammation is characterized by the alteration in adipokine regulation, which may lead to a situation of cardiometabolic risk. The aim of this study was to evaluate the effects of a concurrent training program on markers of lipoinflammation in adult people with obesity, comparing the response to the training between men and women. A quasi-experimental, quantitative, and longitudinal study with a pre-post intervention was conducted. An 8-week concurrent training program was carried out, in which 26 individuals with obesity participated (mean +/- SD; age = 46.38 +/- 4.66) (BMI = 36.05 +/- 4.99) (12 men and 14 women). Before and after the intervention period, blood samples were taken by percutaneous puncture. The blood levels of adiponectin and leptin were evaluated. Significant differences were obtained in the adiponectin-leptin ratio (A/L ratio) of the entire sample (p = 0.009, ES = 0.53), which indicates a decrease in the risk of cardiovascular diseases and lipoinflammation. There were no significant differences in the improvements observed after the training in A/L ratio between women (A/L change = +63.5%) and men (A/L change= +59.2%). It can be concluded that the combination of aerobic exercise and resistance training induced an improvement in markers of lipoinflammation and cardiometabolic risk in the individuals with obesity evaluated in this study.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijerph17176168
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gonzalez-Jurado&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Changes+in+Lipoinflammation+Markers+in+People+with+Obesity+after+a+Concurrent+Training+Program%3A+A+Comparison+between+Men+and+Women.&volume=17&issue=17&spage=&epage=&date=2020&doi=10.3390%2Fijerph17176168&pmid=32854366&sid=OVID:medline
+
+<1210>
+Unique Identifier
+ 32849295
+Title
+ Association Between Metabolic and Hormonal Derangements and Professional Exposure to Urban Pollution in a High Intensity Traffic Area.
+Source
+ Frontiers in Endocrinology. 11:509, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Molfino A; Amabile MI; Muscaritoli M; Germano A; Alfano R; Ramaccini C; Spagnoli A; Cavaliere L; Marseglia G; Nardone A; Muto G; Carbone U; Triassi M; Fiorito S
+Authors Full Name
+ Molfino, Alessio; Amabile, Maria Ida; Muscaritoli, Maurizio; Germano, Annunziata; Alfano, Rossella; Ramaccini, Cesarina; Spagnoli, Alessandra; Cavaliere, Liberato; Marseglia, Gianluca; Nardone, Antonio; Muto, Giuseppina; Carbone, Umberto; Triassi, Maria; Fiorito, Silvana.
+Institution
+ Molfino, Alessio. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
+ Amabile, Maria Ida. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
+ Amabile, Maria Ida. Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
+ Muscaritoli, Maurizio. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
+ Germano, Annunziata. Department of Public Health, University Federico II, Naples, Italy.
+ Alfano, Rossella. Department of Public Health, University Federico II, Naples, Italy.
+ Ramaccini, Cesarina. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
+ Spagnoli, Alessandra. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
+ Cavaliere, Liberato. Department of Public Health, University Federico II, Naples, Italy.
+ Marseglia, Gianluca. Department of Public Health, University Federico II, Naples, Italy.
+ Nardone, Antonio. Department of Public Health, University Federico II, Naples, Italy.
+ Muto, Giuseppina. Department of Public Health, University Federico II, Naples, Italy.
+ Carbone, Umberto. Department of Public Health, University Federico II, Naples, Italy.
+ Triassi, Maria. Department of Public Health, University Federico II, Naples, Italy.
+ Fiorito, Silvana. Institute of Translational Pharmacology, CNR, Rome, Italy.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ *Air Pollution/ae [Adverse Effects]
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ Ghrelin/bl [Blood]
+ Humans
+ *Insulin Resistance
+ Leptin/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/pa [Pathology]
+ Middle Aged
+ *Obesity/co [Complications]
+ *Particulate Matter/ae [Adverse Effects]
+ *Traffic-Related Pollution/ae [Adverse Effects]
+Keyword Heading
+ adiponectin
+ air pollution
+ insulin resistance
+ leptin
+ metabolic syndrome
+ particulate matter
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Rationale: Studies suggest a relation between exposure to air particulate matter (PM)2.5 pollution and greater cardiovascular morbidity, as well as increased risk for obesity and diabetes. We aimed to identify association(s) between nutritional and metabolic status and exposure to environmental pollution in a cohort of policemen exposed to high levels of air pollution. Methods: We considered adult municipal policemen, working in an urban area at high-traffic density with documented high levels of air PM2.5 (exposed group) compared to non-exposed policemen. Clinical characteristics, including the presence/absence of metabolic syndrome, were recorded, and serum biomarkers, including adiponectin, leptin, and ghrelin, were assessed. Results: One hundred ninety-nine participants were enrolled, 100 in the exposed group and 99 in the non-exposed group. Metabolic syndrome was documented in 32% of exposed group and in 52.5% of non-exposed group (P = 0.008). In the exposed group, we found a positive correlation between body mass index and serum leptin as well as in the non-exposed group (P < 0.0001). Within the exposed group, subjects with metabolic syndrome showed lower serum adiponectin (P < 0.0001) and higher leptin (P = 0.002) levels with respect to those without metabolic syndrome, whereas in the non-exposed group, subjects with metabolic syndrome showed only higher leptin levels when compared to those without metabolic syndrome (P = 0.01). Among the participants with metabolic syndrome, we found lower adiponectin levels in those of the exposed group with respect to the non-exposed ones (P = 0.007). When comparing the exposed and non-exposed groups, after stratifying participants for Homeostatic Model Assessment for Insulin Resistance >2.5, we found lower adiponectin levels in those of the exposed group with respect to the non-exposed ones (P = 0.038). Conclusions: Exposure to air PM pollution was associated with lower levels of adiponectin in adult males with metabolic syndrome. Copyright © 2020 Molfino, Amabile, Muscaritoli, Germano, Alfano, Ramaccini, Spagnoli, Cavaliere, Marseglia, Nardone, Muto, Carbone, Triassi and Fiorito.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Ghrelin). 0 (Leptin). 0 (Particulate Matter).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffendo.2020.00509
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Molfino&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Association+Between+Metabolic+and+Hormonal+Derangements+and+Professional+Exposure+to+Urban+Pollution+in+a+High+Intensity+Traffic+Area.&volume=11&issue=&spage=509&epage=&date=2020&doi=10.3389%2Ffendo.2020.00509&pmid=32849295&sid=OVID:medline
+
+<1211>
+Unique Identifier
+ 32845571
+Title
+ Obesity is common in chronic kidney disease and associates with greater antihypertensive usage and proteinuria: evidence from a cross-sectional study in a tertiary nephrology centre.
+Source
+ Clinical Obesity. 10(6):e12402, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Martin WP; Bauer J; Coleman J; Dellatorre-Teixeira L; Reeve JLV; Twomey PJ; Docherty NG; O'Riordan A; Watson AJ; le Roux CW; Holian J
+Author NameID
+ Martin, William P; ORCID: https://orcid.org/0000-0001-7005-3966
+ Docherty, Neil G; ORCID: https://orcid.org/0000-0002-0961-2607
+Authors Full Name
+ Martin, William P; Bauer, Jessica; Coleman, John; Dellatorre-Teixeira, Ludmilla; Reeve, Janice L V; Twomey, Patrick J; Docherty, Neil G; O'Riordan, Aisling; Watson, Alan J; le Roux, Carel W; Holian, John.
+Institution
+ Martin, William P. Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
+ Martin, William P. Department of Nephrology, St. Vincent's University Hospital, Dublin, Ireland.
+ Bauer, Jessica. Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
+ Coleman, John. Department of Nephrology, St. Vincent's University Hospital, Dublin, Ireland.
+ Dellatorre-Teixeira, Ludmilla. Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
+ Reeve, Janice L V. Department of Clinical Chemistry, St. Vincent's University Hospital, Dublin, Ireland.
+ Twomey, Patrick J. Department of Clinical Chemistry, St. Vincent's University Hospital, Dublin, Ireland.
+ Docherty, Neil G. Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
+ Docherty, Neil G. Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ O'Riordan, Aisling. Department of Nephrology, St. Vincent's University Hospital, Dublin, Ireland.
+ Watson, Alan J. Department of Nephrology, St. Vincent's University Hospital, Dublin, Ireland.
+ le Roux, Carel W. Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
+ le Roux, Carel W. Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ le Roux, Carel W. Division of Investigative Science, Imperial College London, London, UK.
+ Holian, John. Department of Nephrology, St. Vincent's University Hospital, Dublin, Ireland.
+MeSH Subject Headings
+ *Antihypertensive Agents/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Female
+ Glomerular Filtration Rate
+ Humans
+ Hypertension/co [Complications]
+ Hypertension/dt [Drug Therapy]
+ *Hypertension/ep [Epidemiology]
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Male
+ Medical Audit
+ Middle Aged
+ Nephrology/sn [Statistics & Numerical Data]
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/ur [Urine]
+ *Proteinuria/ep [Epidemiology]
+ Proteinuria/et [Etiology]
+ Renal Insufficiency, Chronic/bl [Blood]
+ *Renal Insufficiency, Chronic/co [Complications]
+ Renal Insufficiency, Chronic/ur [Urine]
+ Risk Factors
+ Sex Factors
+ Tertiary Care Centers
+Keyword Heading
+ chronic kidney disease
+ diabetes mellitus
+ diabetic kidney disease
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a treatable risk factor for chronic kidney disease progression. We audited the reporting of body-mass index in nephrology outpatient clinics to establish the characteristics of individuals with obesity in nephrology practice. Body-mass index, clinical information and biochemical measures were recorded for patients attending clinics between 3rd August, 2018 and 18th January, 2019. Inferential statistics and Pearson correlations were used to investigate relationships between body-mass index, type 2 diabetes, hypertension and proteinuria. Mean +/- SD BMI was 28.6 +/- 5.8 kg/m2 (n = 374). Overweight and obesity class 1 were more common in males (P = .02). Amongst n = 123 individuals with obesity and chronic kidney disease, mean +/- SD age, n (%) female and median[IQR] eGFR were 64.1 +/- 14.2 years, 52 (42.3%) and 29.0[20.5] mL/min/BSA, respectively. A positive correlation between increasing body-mass index and proteinuria was observed in such patients (r = 0.21, P = .03), which was stronger in males and those with CKD stages 4 and 5. Mean body-mass index was 2.3 kg/m2 higher in those treated with 4-5 versus 0-1 antihypertensives (P = .03). Amongst n = 59 patients with obesity, chronic kidney disease and type 2 diabetes, 2 (3.5%) and 0 (0%) were prescribed a GLP-1 receptor analogue and SGLT2-inhibitor, respectively. Our data provides a strong rationale not only for measuring body-mass index but also for acting on the information in nephrology practice, although prospective studies are required to guide treatment decisions in people with obesity and chronic kidney disease. Copyright © 2020 The Authors. Clinical Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (Antihypertensive Agents). 0 (Biomarkers). 0 (Hypoglycemic Agents).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fcob.12402
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Martin&issn=1758-8103&title=Clinical+Obesity&atitle=Obesity+is+common+in+chronic+kidney+disease+and+associates+with+greater+antihypertensive+usage+and+proteinuria%3A+evidence+from+a+cross-sectional+study+in+a+tertiary+nephrology+centre.&volume=10&issue=6&spage=e12402&epage=&date=2020&doi=10.1111%2Fcob.12402&pmid=32845571&sid=OVID:medline
+
+<1212>
+Unique Identifier
+ 32831638
+Title
+ Midregional Proadrenomedullin (MRproADM) Serum Levels in Critically Ill Patients Are Associated with Short-Term and Overall Mortality during a Two-Year Follow-Up.
+Source
+ Mediators of Inflammation. 2020:7184803, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Buendgens L; Yagmur E; Ginsberg A; Weiskirchen R; Wirtz T; Jhaisha SA; Eisert A; Luedde T; Trautwein C; Tacke F; Koch A
+Author NameID
+ Weiskirchen, Ralf; ORCID: https://orcid.org/0000-0003-3888-0931
+ Luedde, Tom; ORCID: https://orcid.org/0000-0002-6288-8821
+ Tacke, Frank; ORCID: https://orcid.org/0000-0001-6206-0226
+ Koch, Alexander; ORCID: https://orcid.org/0000-0002-4452-4151
+Authors Full Name
+ Buendgens, Lukas; Yagmur, Eray; Ginsberg, Axel; Weiskirchen, Ralf; Wirtz, Theresa; Jhaisha, Samira Abu; Eisert, Albrecht; Luedde, Tom; Trautwein, Christian; Tacke, Frank; Koch, Alexander.
+Institution
+ Buendgens, Lukas. Department of Medicine III, RWTH-University Hospital Aachen, Germany.
+ Yagmur, Eray. Medical Care Center, Dr Stein and Colleagues, Monchengladbach, Germany.
+ Ginsberg, Axel. Department of Medicine III, RWTH-University Hospital Aachen, Germany.
+ Weiskirchen, Ralf. Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH-University Hospital Aachen, Germany.
+ Wirtz, Theresa. Department of Medicine III, RWTH-University Hospital Aachen, Germany.
+ Jhaisha, Samira Abu. Department of Medicine III, RWTH-University Hospital Aachen, Germany.
+ Eisert, Albrecht. Hospital Pharmacy, RWTH-University Hospital Aachen, Germany.
+ Eisert, Albrecht. Institute of Clinical Pharmacology, RWTH-University Hospital Aachen, Germany.
+ Luedde, Tom. Department of Medicine III, RWTH-University Hospital Aachen, Germany.
+ Trautwein, Christian. Department of Medicine III, RWTH-University Hospital Aachen, Germany.
+ Tacke, Frank. Department of Hepatology and Gastroenterology, Charite University Medicine Berlin, Germany.
+ Koch, Alexander. Department of Medicine III, RWTH-University Hospital Aachen, Germany.
+MeSH Subject Headings
+ APACHE
+ Adolescent
+ *Adrenomedullin/bl [Blood]
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Critical Illness
+ Female
+ Humans
+ Intensive Care Units/sn [Statistics & Numerical Data]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Protein Precursors/bl [Blood]
+ Young Adult
+Abstract
+ Adrenomedullin (ADM) is a peptide with pleiotropic effects in systemic inflammation. Its more stable precursor protein midregional proadrenomedullin (MRproADM) can be measured more reliably compared to ADM. Our objective was to investigate the potential role of MRproADM as a diagnostic and prognostic biomarker in critically ill patients at the intensive care unit (ICU). We therefore measured MRproADM in 203 ICU patients and 66 healthy controls. We found that MRproADM levels are significantly increased in critically ill patients as compared to healthy controls. MRproADM levels are significantly increased in patients with sepsis, but its diagnostic value for identifying sepsis is numerically lower than that of established markers (e.g., interleukin-6, C-reactive protein, and procalcitonin). MRproADM levels are closely correlated to endothelial and organ dysfunction, inflammation, and established clinical scores (APACHE II, SOFA, and SAPS2). MRproADM concentrations correlate with vasopressor use but not fluid balance. Increased MRproADM levels (cut - off > 1.4 nmol/L) in critically ill patients are independent predictors of ICU and overall mortality during a follow-up of up to 26 months (OR 3.15 for ICU mortality, 95% CI 1.08-9.20, p = 0.036; OR for overall mortality 2.4, 95% CI 1.12-5.34, p = 0.026). Our study demonstrates the potential of MRproADM serum levels as a prognostic biomarker in critical illness for ICU mortality and long-term survival during follow-up. Copyright © 2020 Lukas Buendgens et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Protein Precursors). 0 (proadrenomedullin). 148498-78-6 (Adrenomedullin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1155%2f2020%2f7184803
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Buendgens&issn=0962-9351&title=Mediators+of+Inflammation&atitle=Midregional+Proadrenomedullin+%28MRproADM%29+Serum+Levels+in+Critically+Ill+Patients+Are+Associated+with+Short-Term+and+Overall+Mortality+during+a+Two-Year+Follow-Up.&volume=2020&issue=&spage=7184803&epage=&date=2020&doi=10.1155%2F2020%2F7184803&pmid=32831638&sid=OVID:medline
+
+<1213>
+Unique Identifier
+ 32827764
+Title
+ Are Cape Peninsula baboons raiding their way to obesity and type II diabetes? - a comparative study.
+Source
+ Comparative Biochemistry & Physiology. Part A, Molecular & Integrative Physiology. 250:110794, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leith DA; Mpofu BS; van Velden JL; Reed CC; van Boom KM; Breed D; Kohn TA
+Authors Full Name
+ Leith, David Alexander; Mpofu, Buhlebethu Sukoluhle; van Velden, Julia Laura; Reed, Cecile Catharine; van Boom, Kathryn Merle; Breed, Dorothy; Kohn, Tertius Abraham.
+Institution
+ Leith, David Alexander. Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, South Africa.
+ Mpofu, Buhlebethu Sukoluhle. Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, South Africa.
+ van Velden, Julia Laura. Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, South Africa; Department of Biological Sciences, University of Cape Town, South Africa.
+ Reed, Cecile Catharine. Department of Biological Sciences, University of Cape Town, South Africa.
+ van Boom, Kathryn Merle. Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, South Africa; Department of Medical Bioscience, Faculty of Natural Sciences, University of the Western Cape, South Africa.
+ Breed, Dorothy. Biodiversity Management Branch, Environmental Management Department, City of Cape Town, 53 Berkley Road, Maitland, 6504, South Africa.
+ Kohn, Tertius Abraham. Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, South Africa; Department of Medical Bioscience, Faculty of Natural Sciences, University of the Western Cape, South Africa. Electronic address: tkohn@uwc.ac.za.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ *Diabetes Mellitus, Experimental/et [Etiology]
+ *Feeding Behavior
+ Insulin Resistance
+ Muscle, Skeletal/me [Metabolism]
+ *Obesity/et [Etiology]
+ *Papio/ph [Physiology]
+ South Africa
+Keyword Heading
+ Cross-sectional area
+ Mitochondria
+ Obesity
+ Primate
+ Wild animal
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Researchers, managers and conservationists in the Cape Peninsula, South Africa, have reported cases of individual baboons (Papio ursinus) appearing overweight, lethargic and having poor teeth. Despite an intensive baboon management programme, there are certain individual baboons and troops that continue to raid human food sources. These food sources often are high in processed carbohydrates and saturated fats. As this diet is highly associated with obesity, insulin resistance and type II diabetes, the present study aimed to establish if these baboons may be at risk of developing insulin resistance. Post mortem muscle samples from 17 Cape Peninsula and 7 control adult male baboons were rapidly frozen in liquid nitrogen and analysed for insulin receptor substrate-1 (IRS-1), glucose transporter 4 (GLUT4), oxidative and glycolytic markers of metabolism (citrate synthase, 3-hydroxyacyl-CoA-dehydrogenase, lactate dehydrogenase and creatine kinase activities), and muscle fibre morphology. The sampled Peninsula baboons were heavier (33 +/- 2 vs. 29 +/- 2 kg, P < 0.05) and had a higher frequency of poor teeth compared to control baboons. Muscle fibre type, fibre size, GLUT4 content, oxidative and glycolytic metabolism were not different between the two groups. However, IRS-1 content, a marker of insulin sensitivity, was significantly lower (by 43%, P < 0.001) in the Peninsula baboons compared to the controls. This study provides the first indirect evidence that some Peninsula baboons with a history of raiding human food sources, may be at risk of developing insulin resistance in the wild, with long term implications for population health. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.cbpa.2020.110794
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leith&issn=1095-6433&title=Comparative+Biochemistry+%26+Physiology.+Part+A%2C+Molecular+%26+Integrative+Physiology&atitle=Are+Cape+Peninsula+baboons+raiding+their+way+to+obesity+and+type+II+diabetes%3F+-+a+comparative+study.&volume=250&issue=&spage=110794&epage=&date=2020&doi=10.1016%2Fj.cbpa.2020.110794&pmid=32827764&sid=OVID:medline
+
+<1214>
+Unique Identifier
+ 32820223
+Title
+ Markers of remodeling in subcutaneous adipose tissue are strongly associated with overweight and insulin sensitivity in healthy non-obese men.
+Source
+ Scientific Reports. 10(1):14055, 2020 08 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Akra S; Aksnes TA; Flaa A; Eggesbo HB; Opstad TB; Njerve IU; Seljeflot I
+Authors Full Name
+ Akra, Sissel; Aksnes, Tonje A; Flaa, Arnljot; Eggesbo, Heidi B; Opstad, Trine Baur; Njerve, Ida U; Seljeflot, Ingebjorg.
+Institution
+ Akra, Sissel. Department of Cardiology, Center for Clinical Heart Research, Oslo University Hospital, Ulleval, Pb 4956 Nydalen, 0424, Oslo, Norway. uxkrsi@ous-hf.no.
+ Aksnes, Tonje A. Section of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway.
+ Aksnes, Tonje A. Section for Interventional Cardiology, Department of Cardiology, Heart-, Lung-, and Vascular-Disease Clinic, Oslo University Hospital, Oslo, Norway.
+ Flaa, Arnljot. Section of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway.
+ Flaa, Arnljot. Department of Cardiology, Oslo University Hospital, Ulleval, Oslo, Norway.
+ Eggesbo, Heidi B. Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
+ Opstad, Trine Baur. Department of Cardiology, Center for Clinical Heart Research, Oslo University Hospital, Ulleval, Pb 4956 Nydalen, 0424, Oslo, Norway.
+ Opstad, Trine Baur. Faculty of Medicine, University of Oslo, Oslo, Norway.
+ Njerve, Ida U. Department of Cardiology, Center for Clinical Heart Research, Oslo University Hospital, Ulleval, Pb 4956 Nydalen, 0424, Oslo, Norway.
+ Seljeflot, Ingebjorg. Department of Cardiology, Center for Clinical Heart Research, Oslo University Hospital, Ulleval, Pb 4956 Nydalen, 0424, Oslo, Norway.
+ Seljeflot, Ingebjorg. Department of Cardiology, Oslo University Hospital, Ulleval, Oslo, Norway.
+ Seljeflot, Ingebjorg. Faculty of Medicine, University of Oslo, Oslo, Norway.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Overweight/me [Metabolism]
+ *Subcutaneous Fat/me [Metabolism]
+Abstract
+ Alteration in extracellular matrix (ECM) in adipose tissues (AT) has been associated with insulin resistance, diabetes and obesity. We investigated whether selected biomarkers of ECM remodeling in AT in healthy subjects associated with the amount and distribution of AT and with glucometabolic variables. Subcutaneous AT and fasting blood samples from 103 middle-aged healthy non-obese men were used. AT gene expression and circulating levels of the biomarkers were quantified. Distribution of AT was assessed by computed tomography, separated into subcutaneous, deep subcutaneous and visceral AT. Insulin sensitivity was measured by glucose clamp technique. Metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-1 and plasminogen activator inhibitor (PAI)-1 expression in AT correlated significantly to the amount of AT in all compartments (rs = 0.41-0.53, all p <= 0.01), and to insulin sensitivity, insulin, C-peptide, waist circumference and body mass index (BMI) (rs = 0.25-0.57, all p <= 0.05). MMP-9 was 5.3 fold higher in subjects with insulin sensitivity below median (p = 0.002) and 3.1 fold higher in subjects with BMI above median level (p = 0.013). In our healthy non-obese middle-aged population AT-expressed genes, central in remodeling of ECM, associated strongly with the amount of abdominal AT, overweight and insulin sensitivity, indicating AT-remodeling to play a role also in non-obese individuals. The remodeling process seems furthermore to associate significantly with glucometabolic disturbances.Trial registration: ClinicalTrials.gov, NCT01412554. Registered 9 August 2011, https://clinicaltrials.gov/ct2/show/NCT01412554?term=NCT01412554 .
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-71109-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Akra&issn=2045-2322&title=Scientific+Reports&atitle=Markers+of+remodeling+in+subcutaneous+adipose+tissue+are+strongly+associated+with+overweight+and+insulin+sensitivity+in+healthy+non-obese+men.&volume=10&issue=1&spage=14055&epage=&date=2020&doi=10.1038%2Fs41598-020-71109-4&pmid=32820223&sid=OVID:medline
+
+<1215>
+Unique Identifier
+ 32814439
+Title
+ High-Mobility Group Box-1 Is Associated With Obesity, Inflammation, and Subclinical Cardiovascular Risk Among Young Adults: A Longitudinal Cohort Study.
+Source
+ Arteriosclerosis, Thrombosis & Vascular Biology. 40(11):2776-2784, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen L; Zhu H; Su S; Harshfield G; Sullivan J; Webb C; Blumenthal JA; Wang X; Huang Y; Treiber FA; Kapuku G; Li W; Dong Y
+Authors Full Name
+ Chen, Li; Zhu, Haidong; Su, Shaoyong; Harshfield, Gregory; Sullivan, Jennifer; Webb, Clinton; Blumenthal, James A; Wang, Xiaoling; Huang, Ying; Treiber, Frank A; Kapuku, Gaston; Li, Wenjun; Dong, Yanbin.
+Institution
+ Chen, Li. Georgia Prevention Institute, Department of Medicine (L.C., H.Z., G.H., X.W., Y.H., G.K., Y.D.), Medical College of Georgia, Augusta University.
+ Zhu, Haidong. Department of Physiology (J.S., C.W.), Medical College of Georgia, Augusta University.
+ Su, Shaoyong. Georgia Prevention Institute, Department of Medicine (L.C., H.Z., G.H., X.W., Y.H., G.K., Y.D.), Medical College of Georgia, Augusta University.
+ Harshfield, Gregory. Georgia Prevention Institute, Department of Medicine (L.C., H.Z., G.H., X.W., Y.H., G.K., Y.D.), Medical College of Georgia, Augusta University.
+ Sullivan, Jennifer. Department of Physiology (J.S., C.W.), Medical College of Georgia, Augusta University.
+ Webb, Clinton. Department of Physiology (J.S., C.W.), Medical College of Georgia, Augusta University.
+ Blumenthal, James A. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC (J.A.B.).
+ Wang, Xiaoling. Georgia Prevention Institute, Department of Medicine (L.C., H.Z., G.H., X.W., Y.H., G.K., Y.D.), Medical College of Georgia, Augusta University.
+ Huang, Ying. Georgia Prevention Institute, Department of Medicine (L.C., H.Z., G.H., X.W., Y.H., G.K., Y.D.), Medical College of Georgia, Augusta University.
+ Treiber, Frank A. College of Nursing (F.A.T.), Medical University of South Carolina, Charleston.
+ Treiber, Frank A. College of Medicine (F.A.T.), Medical University of South Carolina, Charleston.
+ Kapuku, Gaston. Georgia Prevention Institute, Department of Medicine (L.C., H.Z., G.H., X.W., Y.H., G.K., Y.D.), Medical College of Georgia, Augusta University.
+ Li, Wenjun. Department of Medicine, University of Massachusetts Medical School, Worcester (W.L.).
+ Dong, Yanbin. Georgia Prevention Institute, Department of Medicine (L.C., H.Z., G.H., X.W., Y.H., G.K., Y.D.), Medical College of Georgia, Augusta University.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Black or African American
+ Age Factors
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/eh [Ethnology]
+ Female
+ Georgia/ep [Epidemiology]
+ *HMGB1 Protein/bl [Blood]
+ Heart Disease Risk Factors
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/di [Diagnosis]
+ Inflammation/eh [Ethnology]
+ Longitudinal Studies
+ Male
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/eh [Ethnology]
+ Prognosis
+ Race Factors
+ Risk Assessment
+ Sex Factors
+ Time Factors
+ Up-Regulation
+ White People
+ Young Adult
+Keyword Heading
+ C-reactive protein
+ blood pressure
+ inflammation
+ obesity
+ vascular stiffness
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: We aimed to characterize circulating HMGB1 (high-mobility group box-1) levels, one of the better-characterized damage-associated molecular patterns, with respect to age, sex, and race in the general population, and investigate the longitudinal associations of HMGB1 with inflammatory markers, obesity, and preclinical markers of cardiovascular disease. Approach and Results: The analyses included 489 participants (50% Blacks, aged 24.6+/-3.3 years at the first visit) with up to 4 follow-up visits (1149 samples) over a maximum of 8.5 years. Systolic blood pressure, diastolic blood pressure, carotid-femoral pulse wave velocity, and carotid intima-media thickness together with plasma HMGB1, hs-CRP (high-sensitivity C-reactive protein), IFN-gamma (interferon-gamma), IL-6 (interleukin-6), IL-10 (interleukin-10), and TNF-alpha (tumor necrosis factor-alpha) were measured at each visit. At baseline, plasma HMGB1 concentrations were higher in Blacks compared with Whites (3.86 versus 3.20 ng/mL, P<0.001), and in females compared with males (3.75 versus 3.30 ng/mL, P=0.005). HMGB1 concentrations increased with age (P=0.007), and higher levels of obesity measures (P<0.001). Without adjustment for age, sex, race, and body mass index, HMGB1 concentrations were positively associated with hs-CRP, IL-6, TNF-alpha, systolic blood pressure, diastolic blood pressure, and carotid-femoral pulse wave velocity (P<0.05) but not IL-10, IFN-gamma or carotid intima-media thickness. After covariate adjustments, the associations of HMGB1 with hs-CRP, and carotid-femoral pulse wave velocity remained statistically significant (P<0.05).
+
+ CONCLUSIONS: This study demonstrates the age, sex, and race differences in circulating HMGB1. The increasing circulating concentrations of HMGB1 with age suggest a potential role of HMGB1 in the pathogenesis of chronic low-grade inflammation, obesity, and subclinical cardiovascular disease risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (HMGB1 Protein). 0 (HMGB1 protein, human).
+Publication Type
+ Comparative Study. Journal Article. Observational Study. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1161%2fATVBAHA.120.314599
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1079-5642&title=Arteriosclerosis%2C+Thrombosis+%26+Vascular+Biology&atitle=High-Mobility+Group+Box-1+Is+Associated+With+Obesity%2C+Inflammation%2C+and+Subclinical+Cardiovascular+Risk+Among+Young+Adults%3A+A+Longitudinal+Cohort+Study.&volume=40&issue=11&spage=2776&epage=2784&date=2020&doi=10.1161%2FATVBAHA.120.314599&pmid=32814439&sid=OVID:medline
+
+<1216>
+Unique Identifier
+ 32809962
+Title
+ Ambulatory blood pressure profile in office normotensive obese children: prevalence of masked hypertension and impact of parental hypertension.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 33(10):1313-1320, 2020 Aug 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Valent Moric B; Jelakovic B; Vidatic I; Trutin I; Jelakovic A; Stipancic G
+Author NameID
+ Valent Moric, Bernardica; ORCID: https://orcid.org/0000-0001-6516-5955
+Authors Full Name
+ Valent Moric, Bernardica; Jelakovic, Bojan; Vidatic, Ines; Trutin, Ivana; Jelakovic, Ana; Stipancic, Gordana.
+Institution
+ Valent Moric, Bernardica. Department of Pediatrics, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
+ Jelakovic, Bojan. Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia.
+ Vidatic, Ines. Department of Pediatrics, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
+ Trutin, Ivana. Department of Pediatrics, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
+ Jelakovic, Ana. Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia.
+ Stipancic, Gordana. Department of Pediatrics, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/an [Analysis]
+ *Blood Pressure Monitoring, Ambulatory/mt [Methods]
+ Body Mass Index
+ Body Weight
+ Case-Control Studies
+ Child
+ Croatia/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ *Genetic Predisposition to Disease
+ Heart Rate
+ Humans
+ *Hypertension/ep [Epidemiology]
+ Hypertension/pa [Pathology]
+ Male
+ *Obesity/pp [Physiopathology]
+ Parents
+ Prevalence
+ Prognosis
+Keyword Heading
+ ambulatory blood pressure
+ children
+ masked hypertension
+ obesity
+ parental hypertension
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objectives The objectives of this study were to analyze ambulatory blood pressure (ABP) data in office normotensive obese children, to determine the prevalence and characteristics of masked hypertension (MH) and to investigate the impact of parental hypertension (PH) on ABP. Methods Seventy-nine obese and 35 normal weight children were enrolled. Each weight group was further divided in accordance with the presence of PH. ABP was recorded in an outpatient setting. Results Obese children had higher systolic ABP (p<0.05) and heart rate (p<0.001) compared with normal weight children. In obese children with PH, only nighttime systolic ABP (p=0.01) was higher compared with obese without PH, whereas normal weight children with PH had higher 24 h and daytime systolic and diastolic BP (all p<0.05) and nighttime DBP (p<0.001) compared with those without PH. PH but not obesity was associated with nondipping phenomenon. Prevalence of MH in the whole group was 23.6% being significantly higher in obese than in nonobese subjects (31.6 vs. 5.7%; p=0.0026) as well as in obese subjects with PH compared with obese subjects without PH (48.7 vs. 15%; chi2=10.37; p=0.001). MH was diagnosed more frequently in obese with high-normal office BP compared with obese with normal office BP, although it did not reach statistical significance (50 vs. 26.2%; chi2=3.631; p=0.056). In the normal weight group, neither PH nor office BP category had an impact on the prevalence of MH. Conclusions Office normotensive obese children had higher ABP values. MH was associated with obesity, PH and high-normal BP.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1515%2fjpem-2020-0269
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Valent+Moric&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Ambulatory+blood+pressure+profile+in+office+normotensive+obese+children%3A+prevalence+of+masked+hypertension+and+impact+of+parental+hypertension.&volume=33&issue=10&spage=1313&epage=1320&date=2020&doi=10.1515%2Fjpem-2020-0269&pmid=32809962&sid=OVID:medline
+
+<1217>
+Unique Identifier
+ 32809874
+Title
+ Obese-Inflammatory Phenotypes in Heart Failure With Preserved Ejection Fraction.
+Source
+ Circulation: Heart Failure. 13(8):e006414, 2020 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sabbah MS; Fayyaz AU; de Denus S; Felker GM; Borlaug BA; Dasari S; Carter RE; Redfield MM
+Authors Full Name
+ Sabbah, Michael S; Fayyaz, Ahmed U; de Denus, Simon; Felker, G Michael; Borlaug, Barry A; Dasari, Surendra; Carter, Rickey E; Redfield, Margaret M.
+Institution
+ Sabbah, Michael S. Department of Cardiovascular Disease (M.S.S., A.U.F., B.A.B., M.M.R.), Mayo Clinic, Rochester, MN.
+ Sabbah, Michael S. Center for Regenerative Medicine (M.S.S.), Mayo Clinic, Rochester, MN.
+ Fayyaz, Ahmed U. Department of Cardiovascular Disease (M.S.S., A.U.F., B.A.B., M.M.R.), Mayo Clinic, Rochester, MN.
+ de Denus, Simon. Research Centre, Montreal Heart Institute, QC, Canada (S.d.D.).
+ de Denus, Simon. Universite de Montreal Beaulieu-Saucier Pharmacogenomics Center, QC, Canada (S.d.D.).
+ de Denus, Simon. Department of Pharmacy, Universite de Montreal, QC, Canada (S.d.D.).
+ Felker, G Michael. Duke Clinical Research Institute, Duke University, Durham, NC (G.M.F.).
+ Borlaug, Barry A. Department of Cardiovascular Disease (M.S.S., A.U.F., B.A.B., M.M.R.), Mayo Clinic, Rochester, MN.
+ Dasari, Surendra. Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (S.D., R.E.C.).
+ Carter, Rickey E. Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (S.D., R.E.C.).
+ Redfield, Margaret M. Department of Cardiovascular Disease (M.S.S., A.U.F., B.A.B., M.M.R.), Mayo Clinic, Rochester, MN.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Comorbidity
+ Female
+ *Heart Failure/pp [Physiopathology]
+ Humans
+ *Inflammation/co [Complications]
+ Male
+ *Obesity/co [Complications]
+ Phenotype
+ *Stroke Volume/ph [Physiology]
+ Unsupervised Machine Learning
+Keyword Heading
+ cluster analysis
+ fibrosis
+ heart failure
+ inflammation
+ machine learning
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Comorbidity-driven microvascular inflammation is posited as a unifying pathophysiologic mechanism for heart failure with preserved ejection fraction (HFpEF). Obesity is proinflammatory and common in HFpEF. We hypothesized that unique obesity-inflammation HFpEF phenotypes exist and are associated with differences in clinical features, fibrosis biomarkers, and functional performance.
+
+ METHODS: Patients (n=301) from 3 HFpEF clinical trials were studied. Unsupervised machine learning (hierarchical clustering) with obese status and 13 inflammatory biomarkers as input variables was performed. Associations of clusters with HFpEF severity and fibrosis biomarkers (PIIINP [procollagen III N-terminal peptide], CITP [C-telopeptide for type I collagen], IGFBP7 [insulin-like growth factor-binding protein-7], and GAL-3 [galectin-3]) were assessed.
+
+ RESULTS: Hierarchical clustering revealed 3 phenotypes: pan-inflammatory (n=129; 64% obese), noninflammatory (n=83; 55% obese), and obese high CRP (C-reactive protein; n=89; 98% obese). The pan-inflammatory phenotype had more comorbidities and heart failure hospitalizations; higher left atrial volume, NT-proBNP (N-terminal pro-B-type natriuretic peptide), and fibrosis biomarkers; and lower glomerular filtration rate, peak oxygen consumption, 6-minute walk distance, and active hours/day (P<0.05 for all). The noninflammatory phenotype had the most favorable values for all measures. The obese high CRP phenotype resembled the noninflammatory phenotype except for isolated elevation of CRP and lower functional performance. Hierarchical cluster assignment was independent of CRP genotype combinations that alter CRP levels and more biologically plausible than other clustering approaches. Multiple traditional analytic techniques confirmed and extended the hierarchical clustering findings.
+
+ CONCLUSIONS: Unique obesity-inflammation phenotypes exist in HFpEF and are associated with differences in comorbidity burden, HFpEF severity, and fibrosis. These data support comorbidity-driven microvascular inflammation as a pathophysiologic mechanism for many but not all HFpEF patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1161%2fCIRCHEARTFAILURE.119.006414
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sabbah&issn=1941-3289&title=Circulation%3A+Heart+Failure&atitle=Obese-Inflammatory+Phenotypes+in+Heart+Failure+With+Preserved+Ejection+Fraction.&volume=13&issue=8&spage=e006414&epage=&date=2020&doi=10.1161%2FCIRCHEARTFAILURE.119.006414&pmid=32809874&sid=OVID:medline
+
+<1218>
+Unique Identifier
+ 32807639
+Title
+ Energy drink intake and metabolic syndrome: A prospective investigation in young adults.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(10):1679-1684, 2020 09 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Trapp G; Hurworth M; Jacoby P; Christian H; Ambrosini G; Oddy W; Straker L; Mori T; Beilin L; Allen K
+Authors Full Name
+ Trapp, Gina; Hurworth, Miriam; Jacoby, Peter; Christian, Hayley; Ambrosini, Gina; Oddy, Wendy; Straker, Leon; Mori, Trevor; Beilin, Lawrence; Allen, Karina.
+Institution
+ Trapp, Gina. Telethon Kids Institute, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, WA, 6009, Australia; School of Population and Global Health, The University of Western Australia, 35 Stirling Hwy, Crawley, WA, 6009, Australia. Electronic address: gina.trapp@telethonkids.org.au.
+ Hurworth, Miriam. Telethon Kids Institute, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, WA, 6009, Australia.
+ Jacoby, Peter. Telethon Kids Institute, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, WA, 6009, Australia.
+ Christian, Hayley. Telethon Kids Institute, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, WA, 6009, Australia; School of Population and Global Health, The University of Western Australia, 35 Stirling Hwy, Crawley, WA, 6009, Australia.
+ Ambrosini, Gina. School of Population and Global Health, The University of Western Australia, 35 Stirling Hwy, Crawley, WA, 6009, Australia.
+ Oddy, Wendy. Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool St, Hobart, TAS, 7000, Australia.
+ Straker, Leon. School of Physiotherapy and Exercise Science, Curtin University, Bentley, WA, 6102, Australia.
+ Mori, Trevor. Medical School, Royal Perth Hospital Unit, The University of Western Australia, Perth, WA, 6000, Australia.
+ Beilin, Lawrence. Medical School, Royal Perth Hospital Unit, The University of Western Australia, Perth, WA, 6000, Australia.
+ Allen, Karina. School of Psychology, The University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
+MeSH Subject Headings
+ Age Factors
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Body Mass Index
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ *Dyslipidemias/ep [Epidemiology]
+ *Energy Drinks/ae [Adverse Effects]
+ Female
+ Humans
+ Hypertension/di [Diagnosis]
+ *Hypertension/ep [Epidemiology]
+ Hypertension/pp [Physiopathology]
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Time Factors
+ Western Australia/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ BMI
+ Blood pressure
+ Cholesterol
+ EDs
+ Glucose
+ Metabolic syndrome
+ Obesity
+ Young adults
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: There are concerns that energy drinks (EDs) are contributing to upward trends in overweight, obesity, and cardiometabolic conditions in young people. We investigated cross-sectional and prospective associations between frequency of ED-intake in young-adults and (i) body mass index (BMI) and (ii) Metabolic Syndrome (MetS) and its components.
+
+ METHODS AND RESULTS: Participants from the Raine Study at 20-years (n = 1236) and 22 years (n = 1117) self-reported ED-intake, dietary intake, and physical activity, and had blood and anthropometric measures taken. Regression modelling examined associations between ED-intake and BMI, MetS and its components. There was a positive, but not significant, cross-sectional association with BMI and likelihood of MetS with frequent ED use at 20-years (BMI: beta = 0.19; MetS: OR = 1.11) and 22-years (BMI: beta = 0.51; MetS: OR = 1.28). There were no associations in the prospective analysis. After adjustment, significant associations existed between occasional ED-intake and lower HDL-cholesterol (beta = -0.07) and higher fasting triglycerides (beta = 0.16) at 20-years, and lower fasting triglycerides at 22-years (beta = -0.10), but no significant associations in the prospective analyses.
+
+ CONCLUSION: No significant associations existed between frequency of ED-intake, and BMI, MetS or its individual components over two years (ages 20-22 years). Future studies should include volume of EDs consumed and longer follow-up. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.numecd.2020.06.012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Trapp&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Energy+drink+intake+and+metabolic+syndrome%3A+A+prospective+investigation+in+young+adults.&volume=30&issue=10&spage=1679&epage=1684&date=2020&doi=10.1016%2Fj.numecd.2020.06.012&pmid=32807639&sid=OVID:medline
+
+<1219>
+Unique Identifier
+ 32804947
+Title
+ The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15.
+Source
+ PLoS ONE [Electronic Resource]. 15(8):e0231234, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stolina M; Luo X; Dwyer D; Han CY; Chen R; Zhang Y; Xiong Y; Chen Y; Yin J; Shkumatov A; Ason B; Hale C; Veniant MM
+Author NameID
+ Veniant, Murielle M; ORCID: https://orcid.org/0000-0002-1881-8252
+Authors Full Name
+ Stolina, Marina; Luo, Xin; Dwyer, Denise; Han, Chun-Ya; Chen, Rhonda; Zhang, Ying; Xiong, YuMei; Chen, Yinhong; Yin, Jun; Shkumatov, Artem; Ason, Brandon; Hale, Clarence; Veniant, Murielle M.
+Institution
+ Stolina, Marina. Amgen Research, Department of Cardiometabolic, Thousand Oaks, California, United States of America.
+ Luo, Xin. Amgen Research, Genome Analysis Unit, San Francisco, California, United States of America.
+ Dwyer, Denise. Amgen Research, Department of Cardiometabolic, Thousand Oaks, California, United States of America.
+ Han, Chun-Ya. Amgen Research, Department of Cardiometabolic, Thousand Oaks, California, United States of America.
+ Chen, Rhonda. Amgen Research, Department of Cardiometabolic, San Francisco, California, United States of America.
+ Zhang, Ying. Amgen Research, Department of Cardiometabolic, San Francisco, California, United States of America.
+ Xiong, YuMei. Amgen Research, Department of Cardiometabolic, San Francisco, California, United States of America.
+ Chen, Yinhong. Amgen Research, Department of Cardiometabolic, San Francisco, California, United States of America.
+ Yin, Jun. Amgen Research, Genome Analysis Unit, San Francisco, California, United States of America.
+ Shkumatov, Artem. Amgen Research, Department of Translational and Bioanalytical Sciences, San Francisco, California, United States of America.
+ Ason, Brandon. Amgen Research, Department of Cardiometabolic, San Francisco, California, United States of America.
+ Hale, Clarence. Amgen Research, Department of Cardiometabolic, Thousand Oaks, California, United States of America.
+ Veniant, Murielle M. Amgen Research, Department of Cardiometabolic, Thousand Oaks, California, United States of America.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ *Growth Differentiation Factor 15/me [Metabolism]
+ *Growth Differentiation Factor 15/pd [Pharmacology]
+ Heart/ph [Physiology]
+ Heart Failure/pp [Physiopathology]
+ Heart Ventricles/pp [Physiopathology]
+ Kidney/me [Metabolism]
+ Male
+ Metabolic Syndrome/co [Complications]
+ *Metabolic Syndrome/me [Metabolism]
+ Myocardium/me [Metabolism]
+ Obesity/co [Complications]
+ Rats
+ Rats, Inbred Strains
+ Rats, Zucker
+ Stroke Volume/ph [Physiology]
+ Ventricular Function, Left/de [Drug Effects]
+ Ventricular Function, Left/ph [Physiology]
+Abstract
+ Cardiometabolic syndrome has become a global health issue. Heart failure is a common comorbidity of cardiometabolic syndrome. Successful drug development to prevent cardiometabolic syndrome and associated comorbidities requires preclinical models predictive of human conditions. To characterize the heart failure component of cardiometabolic syndrome, cardiometabolic, metabolic, and renal biomarkers were evaluated in lean and obese ZSF1 19- to 32-week-old male rats. Histopathological assessment of kidneys and hearts was performed. Cardiac function, exercise capacity, and left ventricular gene expression were also analyzed. Obese ZSF1 rats exhibited multiple features of human cardiometabolic syndrome by pathological changes in systemic renal, metabolic, and cardiovascular disease circulating biomarkers. Hemodynamic assessment, echocardiography, and decreased exercise capacity confirmed heart failure with preserved ejection fraction. RNA-seq results demonstrated changes in left ventricular gene expression associated with fatty acid and branched chain amino acid metabolism, cardiomyopathy, cardiac hypertrophy, and heart failure. Twelve weeks of growth differentiation factor 15 (GDF15) treatment significantly decreased body weight, food intake, blood glucose, and triglycerides and improved exercise capacity in obese ZSF1 males. Systemic cardiovascular injury markers were significantly lower in GDF15-treated obese ZSF1 rats. Obese ZSF1 male rats represent a preclinical model for human cardiometabolic syndrome with established heart failure with preserved ejection fraction. GDF15 treatment mediated dietary response and demonstrated a cardioprotective effect in obese ZSF1 rats.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Growth Differentiation Factor 15).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0231234
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stolina&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=The+evolving+systemic+biomarker+milieu+in+obese+ZSF1+rat+model+of+human+cardiometabolic+syndrome%3A+Characterization+of+the+model+and+cardioprotective+effect+of+GDF15.&volume=15&issue=8&spage=e0231234&epage=&date=2020&doi=10.1371%2Fjournal.pone.0231234&pmid=32804947&sid=OVID:medline
+
+<1220>
+Unique Identifier
+ 32801129
+Title
+ Improved Detection of Abnormal Glucose Tolerance in Africans: The Value of Combining Hemoglobin A1c With Glycated Albumin.
+Source
+ Diabetes Care. 43(10):2607-2613, 2020 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hobabagabo AF; Osei-Tutu NH; Hormenu T; Shoup EM; DuBose CW; Mabundo LS; Ha J; Sherman A; Chung ST; Sacks DB; Sumner AE
+Author NameID
+ Sumner, Anne E; ORCID: https://orcid.org/0000-0001-9640-8999
+Authors Full Name
+ Hobabagabo, Arsene F; Osei-Tutu, Nana H; Hormenu, Thomas; Shoup, Elyssa M; DuBose, Christopher W; Mabundo, Lilian S; Ha, Joon; Sherman, Arthur; Chung, Stephanie T; Sacks, David B; Sumner, Anne E.
+Institution
+ Hobabagabo, Arsene F. Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ Hobabagabo, Arsene F. National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD.
+ Osei-Tutu, Nana H. Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ Hormenu, Thomas. Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ Shoup, Elyssa M. Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ DuBose, Christopher W. Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ Mabundo, Lilian S. Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ Ha, Joon. Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ Sherman, Arthur. Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ Chung, Stephanie T. Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
+ Sacks, David B. National Institutes of Health Clinical Center, Bethesda, MD.
+ Sumner, Anne E. Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD annes@mail.nih.gov.
+ Sumner, Anne E. National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD.
+MeSH Subject Headings
+ Adult
+ Africa/eh [Ethnology]
+ Aged
+ Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ *Black People/eh [Ethnology]
+ Blood Glucose/an [Analysis]
+ Female
+ Fructosamine/an [Analysis]
+ Fructosamine/bl [Blood]
+ *Glucose Intolerance/di [Diagnosis]
+ Glucose Intolerance/ep [Epidemiology]
+ *Glucose Intolerance/eh [Ethnology]
+ Glucose Tolerance Test/mt [Methods]
+ Glucose Tolerance Test/st [Standards]
+ *Glycated Hemoglobin/an [Analysis]
+ Glycation End Products, Advanced
+ Hemoglobin, Sickle/an [Analysis]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/eh [Ethnology]
+ Predictive Value of Tests
+ Quality Improvement
+ Reproducibility of Results
+ *Serum Albumin/an [Analysis]
+ United States/ep [Epidemiology]
+ Young Adult
+ Glycated Serum Albumin
+Abstract
+ OBJECTIVE: In African-born Blacks living in America, we determined by BMI category 1) prevalence of abnormal glucose tolerance (Abnl-GT) and 2) diagnostic value and reproducibility of hemoglobin A1c (HbA1c), fructosamine, and glycated albumin (GA).
+
+ RESEARCH DESIGN AND METHODS: Participants (n = 416; male, 66%; BMI 27.7 +/- 4.5 kg/m2 [mean +/- SD]) had an oral glucose tolerance test with HbA1c, GA, and fructosamine assayed. These glycemic markers were repeated 11 +/- 7 days later. Abnl-GT diagnosis required 0 h >=5.6 mmol/L (>=100 mg/dL) and/or 2 h >=7.8 mmol/L (>=140 mg/dL). Thresholds for HbA1c, GA, and fructosamine were the values at the 75th percentile for the population (39 mmol/mol [5.7%], 14.2%, and 234 mumol/L, respectively).
+
+ RESULTS: Abnl-GT prevalence in the nonobese was 34% versus 42% in the obese (P = 0.124). Reproducibility was excellent for HbA1c and GA (both kappa >= 0.8), but moderate for fructosamine (kappa = 0.6). Focusing on HbA1c and GA in the nonobese, we found as single tests the sensitivities of HbA1c and GA were 36% versus 37% (P = 0.529). Combining HbA1c and GA, sensitivity increased to 58% because GA identified 37% of Africans with Abnl-GT not detected by HbA1c (P value for both tests vs. HbA1c alone was <0.001). For the obese, sensitivities for HbA1c, GA, and the combined tests were 60%, 27%, and 67%, respectively. Combined test sensitivity did not differ from HbA1c alone (P = 0.25) because GA detected only 10% of obese Africans with Abnl-GT not detected by HbA1c.
+
+ CONCLUSIONS: Adding GA to HbA1c improves detection of Abnl-GT in nonobese Africans. Copyright © 2020 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Glycation End Products, Advanced). 0 (Hemoglobin, Sickle). 0 (Serum Albumin). 4429-04-3 (Fructosamine). 52012-19-8 (hemoglobin AS). 0 (Glycated Serum Albumin).
+Publication Type
+ Clinical Trial. Journal Article. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2337%2fdc20-1119
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hobabagabo&issn=0149-5992&title=Diabetes+Care&atitle=Improved+Detection+of+Abnormal+Glucose+Tolerance+in+Africans%3A+The+Value+of+Combining+Hemoglobin+A1c+With+Glycated+Albumin.&volume=43&issue=10&spage=2607&epage=2613&date=2020&doi=10.2337%2Fdc20-1119&pmid=32801129&sid=OVID:medline
+
+<1221>
+Unique Identifier
+ 32795834
+Title
+ IL-17A and TNF-alpha as potential biomarkers for acute respiratory distress syndrome and mortality in patients with obesity and COVID-19.
+Source
+ Medical Hypotheses. 144:109935, 2020 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leija-Martinez JJ; Huang F; Del-Rio-Navarro BE; Sanchez-Munoz F; Munoz-Hernandez O; Giacoman-Martinez A; Hall-Mondragon MS; Espinosa-Velazquez D
+Authors Full Name
+ Leija-Martinez, Jose J; Huang, Fengyang; Del-Rio-Navarro, Blanca E; Sanchez-Munoz, Fausto; Munoz-Hernandez, Onofre; Giacoman-Martinez, Abraham; Hall-Mondragon, Margareth S; Espinosa-Velazquez, Dario.
+Institution
+ Leija-Martinez, Jose J. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Hospital Infantil de Mexico Federico Gomez, Research Laboratory of Pharmacology, Mexico City, Mexico.
+ Huang, Fengyang. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Hospital Infantil de Mexico Federico Gomez, Research Laboratory of Pharmacology, Mexico City, Mexico. Electronic address: huangfengyang@gmail.com.
+ Del-Rio-Navarro, Blanca E. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Hospital Infantil de Mexico Federico Gomez, Department of Pediatric Allergy Clinical Immunology, Mexico City, Mexico.
+ Sanchez-Munoz, Fausto. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico; Departamento de Inmunologia, Instituto Nacional de Cardiologia "Ignacio Chavez", Mexico City, Mexico.
+ Munoz-Hernandez, Onofre. Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la Salud, Mexico City, Mexico.
+ Giacoman-Martinez, Abraham. Hospital Infantil de Mexico Federico Gomez, Research Laboratory of Pharmacology, Mexico City, Mexico.
+ Hall-Mondragon, Margareth S. Hospital Infantil de Mexico Federico Gomez, Department of Pediatric Allergy Clinical Immunology, Mexico City, Mexico.
+ Espinosa-Velazquez, Dario. Hospital Infantil de Mexico Federico Gomez, Department of Pediatric Allergy Clinical Immunology, Mexico City, Mexico.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *COVID-19/co [Complications]
+ COVID-19/im [Immunology]
+ COVID-19/mo [Mortality]
+ Cytokine Release Syndrome/et [Etiology]
+ Cytokine Release Syndrome/im [Immunology]
+ Cytokine Release Syndrome/mo [Mortality]
+ Humans
+ *Interleukin-17/bl [Blood]
+ Models, Immunological
+ *Obesity/co [Complications]
+ Obesity/im [Immunology]
+ Pandemics
+ *Respiratory Distress Syndrome/et [Etiology]
+ Respiratory Distress Syndrome/im [Immunology]
+ Respiratory Distress Syndrome/mo [Mortality]
+ Respiratory Mucosa/im [Immunology]
+ Respiratory Mucosa/in [Injuries]
+ Risk Factors
+ *Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ Acute respiratory distress syndrome
+ COVID-19
+ IL-17A
+ Mortality
+ Obesity
+ Tumour necrosis factor-alpha
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Coronavirus disease 2019 (COVID-19) was declared a pandemic and international health emergency by the World Health Organization. Patients with obesity with COVID-19 are 7 times more likely to need invasive mechanical ventilation than are patients without obesity (OR 7.36; 95% CI: 1.63-33.14, p = 0.021). Acute respiratory distress syndrome (ARDS) is one of the main causes of death related to COVID-19 and is triggered by a cytokine storm that damages the respiratory epithelium. Interleukins that cause the chronic low-grade inflammatory state of obesity, such as interleukin (IL)-1beta, IL-6, monocyte chemoattractant peptide (MCP)-1, and, in particular, IL-17A and tumour necrosis factor alpha (TNF-alpha), also play very important roles in lung damage in ARDS. Therefore, obesity is associated with an immune state favourable to a cytokine storm. Our hypothesis is that serum concentrations of TNF-alpha and IL-17A are more elevated in patients with obesity and COVID-19, and consequently, they have a greater probability of developing ARDS and death. The immunobiology of IL-17A and TNF-alpha opens a new fascinating field of research for COVID-19. Copyright © 2020. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IL17A protein, human). 0 (Interleukin-17). 0 (TNF protein, human). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.mehy.2020.109935
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leija-Martinez&issn=0306-9877&title=Medical+Hypotheses&atitle=IL-17A+and+TNF-alpha+as+potential+biomarkers+for+acute+respiratory+distress+syndrome+and+mortality+in+patients+with+obesity+and+COVID-19.&volume=144&issue=&spage=109935&epage=&date=2020&doi=10.1016%2Fj.mehy.2020.109935&pmid=32795834&sid=OVID:medline
+
+<1222>
+Unique Identifier
+ 32780629
+Title
+ The Effects of Intermittent Fasting on Glycemic Control and Body Composition in Adults with Obesity and Type 2 Diabetes: A Systematic Review.
+Source
+ Metabolic Syndrome & Related Disorders. 18(10):450-461, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vitale R; Kim Y
+Authors Full Name
+ Vitale, Rosemarie; Kim, Yeonsoo.
+Institution
+ Vitale, Rosemarie. Nutrition and Dietetics, Central Michigan University, Mount Pleasant, Michigan, USA.
+ Kim, Yeonsoo. Nutrition and Dietetics, Central Michigan University, Mount Pleasant, Michigan, USA.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Body Composition
+ *Caloric Restriction
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/dh [Diet Therapy]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ *Fasting
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ *Glycemic Control
+ Humans
+ Male
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Randomized Controlled Trials as Topic
+ Time Factors
+ Treatment Outcome
+ Weight Loss
+Keyword Heading
+ adults
+ glycated hemoglobin a1c
+ intermittent fasting
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The purpose of this study was to evaluate the effects of intermittent fasting on glycemic control and body composition in adults with obesity and type 2 diabetes. Although intermittent fasting has shown some promise in improving glucoregulatory indicators and body composition in adults with obesity, there is currently no systematic review evaluating these effects in adults with obesity and type 2 diabetes. A database search of PubMed, CINHAL, and MEDLINE identified five studies that met inclusion criterion. All studies were randomized controlled trials in adult subjects (n = 46-137) with type 2 diabetes and a body mass index of >=30 kg/m2. Four different intermittent fasting regimens were reviewed. All fasting regimens revealed strong evidence to support intermittent fasting as a feasible diet to improve glycemia and body composition measures within 12-24 weeks. Follow-up 12-18 months after intermittent fasting did not show promising results for continued weight loss and improved glycemic control. The majority of the studies demonstrated insignificant differences between intermittent fasting and continuous energy restriction for measures of glycated hemoglobin a1c and body composition. More data on intermittent fasting in adults with obesity and type 2 diabetes are needed to determine its benefits within this patient population. Future research should include consistent fasting regimens and larger sample sizes to improve the reliability and generalizability of the data. Also, consistent follow-up after a fasting intervention may enhance long-term benefits and should be considered in future research.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1089%2fmet.2020.0048
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vitale&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=The+Effects+of+Intermittent+Fasting+on+Glycemic+Control+and+Body+Composition+in+Adults+with+Obesity+and+Type+2+Diabetes%3A+A+Systematic+Review.&volume=18&issue=10&spage=450&epage=461&date=2020&doi=10.1089%2Fmet.2020.0048&pmid=32780629&sid=OVID:medline
+
+<1223>
+Unique Identifier
+ 32774333
+Title
+ NOD2 Deficiency Promotes Intestinal CD4+ T Lymphocyte Imbalance, Metainflammation, and Aggravates Type 2 Diabetes in Murine Model.
+Source
+ Frontiers in Immunology. 11:1265, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Carlos D; Perez MM; Leite JA; Rocha FA; Martins LMS; Pereira CA; Fraga-Silva TFC; Pucci TA; Ramos SG; Camara NOS; Bonato VLD; Tostes RC; Silva JS
+Authors Full Name
+ Carlos, Daniela; Perez, Malena M; Leite, Jefferson A; Rocha, Fernanda A; Martins, Larissa M S; Pereira, Camila A; Fraga-Silva, Thais F C; Pucci, Tais A; Ramos, Simone G; Camara, Niels O S; Bonato, Vania L D; Tostes, Rita C; Silva, Joao S.
+Institution
+ Carlos, Daniela. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Perez, Malena M. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Leite, Jefferson A. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Rocha, Fernanda A. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Martins, Larissa M S. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Pereira, Camila A. Pharmacology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Fraga-Silva, Thais F C. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Pucci, Tais A. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Ramos, Simone G. Pathology and Legal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Camara, Niels O S. Department of Immunology, Institute of Biomedical Science (ICB), University of Sao Paulo, Ribeirao Preto, Brazil.
+ Bonato, Vania L D. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Tostes, Rita C. Pharmacology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Silva, Joao S. Departments of Biochemistry and Immunology, University of Sao Paulo, Ribeirao Preto, Brazil.
+ Silva, Joao S. Fiocruz-Bi-Institutional Translational Medicine Plataform, Ribeirao Preto, Brazil.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *CD4-Positive T-Lymphocytes/im [Immunology]
+ *CD4-Positive T-Lymphocytes/me [Metabolism]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ Gastrointestinal Microbiome/im [Immunology]
+ Gene Expression Profiling
+ Glucose/me [Metabolism]
+ Immunohistochemistry
+ *Inflammation/et [Etiology]
+ *Inflammation/me [Metabolism]
+ Insulin/bl [Blood]
+ Insulin/me [Metabolism]
+ Intestinal Mucosa/im [Immunology]
+ Intestinal Mucosa/me [Metabolism]
+ Islets of Langerhans/me [Metabolism]
+ Leukocytes/im [Immunology]
+ Leukocytes/me [Metabolism]
+ Lipid Metabolism
+ Mice
+ Mice, Knockout
+ *Nod2 Signaling Adaptor Protein/df [Deficiency]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Permeability
+ Signal Transduction
+Keyword Heading
+ Innate immunity receptor
+ gut microbiota
+ helper T lymphocytes
+ metainflammation
+ obesity and type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Type 2 diabetes (T2D) is a metabolic disease characterized by increased inflammation, NOD-like receptors (NLRs) activation and gut dysbiosis. Our research group has recently reported that intestinal Th17 response limits gut dysbiosis and LPS translocation to visceral adipose tissue (VAT), protecting against metabolic syndrome. However, whether NOD2 receptor contributes intestinal Th17 immunity, modulates dysbiosis-driven metabolic tissue inflammation, and obesity-induced T2D remain poorly understood. In this context, we observed that mice lacking NOD2 fed a high-fat diet (HFD) display severe obesity, exhibit greater adiposity, and more hepatic steatosis compared to HFD-fed wild-type (WT) mice. In addition, they develop increased hyperglycemia, worsening of glucose intolerance, and insulin resistance. Notably, the deficiency of NOD2 causes a deviation from M2 macrophage and regulatory T cells (Treg) to M1 macrophage and mast cells into VAT compared to WT mice fed HFD. An imbalance was also observed in Th17/Th1 cell populations, with reduced IL-17 and IL-22 gene expression in the mesenteric lymph nodes (MLNs) and ileum, respectively, of NOD2-deficient mice fed HFD. 16S rRNA sequencing indicates lower richness, alpha diversity, and a depletion of Allobaculum, Lactobacillus, and enrichment with Bacteroides genera in these mice compared to HFD-fed WT mice. These alterations were associated with disrupted tight-junctions expression, augmented serum LPS, and bacterial translocation into VAT. Overall, NOD2 activation is required for a protective Th17 over Th1 immunity in the gut, which seems to decrease gram-negative bacteria outgrowth in gut microbiota, attenuating the endotoxemia, metainflammation, and protecting against obesity-induced T2D. Copyright © 2020 Carlos, Perez, Leite, Rocha, Martins, Pereira, Fraga-Silva, Pucci, Ramos, Camara, Bonato, Tostes and Silva.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 0 (Nod2 Signaling Adaptor Protein). 0 (Nod2 protein, mouse). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffimmu.2020.01265
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Carlos&issn=1664-3224&title=Frontiers+in+Immunology&atitle=NOD2+Deficiency+Promotes+Intestinal+CD4%2B+T+Lymphocyte+Imbalance%2C+Metainflammation%2C+and+Aggravates+Type+2+Diabetes+in+Murine+Model.&volume=11&issue=&spage=1265&epage=&date=2020&doi=10.3389%2Ffimmu.2020.01265&pmid=32774333&sid=OVID:medline
+
+<1224>
+Unique Identifier
+ 32772182
+Title
+ Plasma leptin level mirrors metabolome alterations in young adults.
+Source
+ Metabolomics. 16(8):87, 2020 08 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kumar AA; Satheesh G; Vijayakumar G; Chandran M; Prabhu PR; Simon L; Kutty VR; Kartha CC; Jaleel A
+Author NameID
+ Jaleel, Abdul; ORCID: https://orcid.org/0000-0003-2536-9093
+Authors Full Name
+ Kumar, A Aneesh; Satheesh, Gopika; Vijayakumar, Gadadharan; Chandran, Mahesh; Prabhu, Priya R; Simon, Leena; Kutty, Vellappillil Raman; Kartha, Chandrasekharan C; Jaleel, Abdul.
+Institution
+ Kumar, A Aneesh. Cardiovascular Diseases & Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695012, India.
+ Kumar, A Aneesh. Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
+ Satheesh, Gopika. Cardiovascular Diseases & Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695012, India.
+ Vijayakumar, Gadadharan. Medical Trust Hospital and Diabetes Care Centre, Kulanada, Pathanamthitta, Kerala, India.
+ Chandran, Mahesh. Mass Spectrometry and Proteomics Core Facility, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695012, India.
+ Prabhu, Priya R. Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695012, India.
+ Simon, Leena. Medical Trust Hospital and Diabetes Care Centre, Kulanada, Pathanamthitta, Kerala, India.
+ Kutty, Vellappillil Raman. Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram, Kerala, 695012, India.
+ Kartha, Chandrasekharan C. Society for Continuing Medical Education & Research, Kerala Institute of Medical Sciences, Thiruvananthapuram, Kerala, 695029, India.
+ Jaleel, Abdul. Cardiovascular Diseases & Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695012, India. jaleel@rgcb.res.in.
+ Jaleel, Abdul. Mass Spectrometry and Proteomics Core Facility, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695012, India. jaleel@rgcb.res.in.
+ Jaleel, Abdul. Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. jaleel@rgcb.res.in.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Chromatography, Liquid/mt [Methods]
+ Diet
+ Energy Metabolism/ph [Physiology]
+ Female
+ Humans
+ *Leptin/bl [Blood]
+ Lipid Metabolism
+ Lipids/bl [Blood]
+ Male
+ Metabolome/ph [Physiology]
+ Metabolomics/mt [Methods]
+ Obesity/bl [Blood]
+ Tandem Mass Spectrometry/mt [Methods]
+Keyword Heading
+ Energy metabolism
+ Hormone metabolism
+ Leptin
+ Untargeted metabolomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Leptin is known to regulate pathways of energy metabolism, reproduction, and control appetite. Whether plasma leptin levels reflect changes in metabolites of these pathways is unknown.
+
+ OBJECTIVES: We aimed to find whether there is an association between leptin levels and levels of metabolites of energy and hormone metabolism.
+
+ METHODS: We performed an untargeted metabolomics analysis of plasma from 110 healthy adults (men: women = 1:1; aged 18-40 years), using liquid chromatography-tandem mass spectrometry. Blood samples were collected from all the study subjects in the fasting state. Clinical features and markers of obesity and Type 2 diabetes mellitus (T2DM) were assessed in all. The association between levels of metabolites and clinical and biochemical parameters was identified using the multivariable-adjusted linear regression model and PLS-DA analysis.
+
+ RESULTS: The leptin level was found to have a significant association with a substantial number of metabolites in women and men. Leptin level was positively associated with glycocholic acid and arachidic acid, metabolites related to energy metabolisms, pregnanediol-3-glucuronide, a metabolite of progesterone metabolism, and quercetin 3'-sulfate, a diet-derived metabolite. Leptin level was negatively associated with ponasteroside A and barringtogenol C levels. Leptin level was positively correlated with adiponectin and negatively with total calorie intake and levels of triglyceride and very-low-density lipoprotein. Leptin levels were associated with lipid and sex hormone metabolism in women, while metabolites involved in amino acid metabolism were correlated to leptin in men.
+
+ CONCLUSION: Our study indicates that leptin level reflects metabolome alterations and hence could be a useful marker to detect early changes in energy and hormone metabolisms.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Leptin). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs11306-020-01708-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kumar&issn=1573-3882&title=Metabolomics&atitle=Plasma+leptin+level+mirrors+metabolome+alterations+in+young+adults.&volume=16&issue=8&spage=87&epage=&date=2020&doi=10.1007%2Fs11306-020-01708-9&pmid=32772182&sid=OVID:medline
+
+<1225>
+Unique Identifier
+ 32770936
+Title
+ The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity.
+Source
+ Molecular Medicine. 26(1):77, 2020 08 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wei BL; Yin RX; Liu CX; Deng GX; Guan YZ; Zheng PF
+Author NameID
+ Yin, Rui-Xing; ORCID: https://orcid.org/0000-0001-7883-4310
+Authors Full Name
+ Wei, Bi-Liu; Yin, Rui-Xing; Liu, Chun-Xiao; Deng, Guo-Xiong; Guan, Yao-Zong; Zheng, Peng-Fei.
+Institution
+ Wei, Bi-Liu. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
+ Yin, Rui-Xing. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China. yinruixing@163.com.
+ Yin, Rui-Xing. Guangxi Key Laboratory Base of Precision Medicine in Cardio-cerebrovascular Disease Control and Prevention, Nanning, Guangxi, 530021, People's Republic of China. yinruixing@163.com.
+ Yin, Rui-Xing. Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, Nanning, Guangxi, 530021, People's Republic of China. yinruixing@163.com.
+ Liu, Chun-Xiao. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
+ Deng, Guo-Xiong. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
+ Guan, Yao-Zong. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
+ Zheng, Peng-Fei. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
+MeSH Subject Headings
+ Alleles
+ Biomarkers
+ Case-Control Studies
+ *Disease Susceptibility
+ Gene Frequency
+ *Gene-Environment Interaction
+ Genetic Predisposition to Disease
+ Genotype
+ *Haplotypes
+ Humans
+ Linkage Disequilibrium
+ Obesity/ep [Epidemiology]
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Polymorphism, Single Nucleotide
+ *Receptor, Melanocortin, Type 4/ge [Genetics]
+ Receptor, Melanocortin, Type 4/me [Metabolism]
+Keyword Heading
+ Environmental factor
+ Melanocortin 4 receptor gene (MC4R)
+ Obesity
+ Single nucleotide polymorphism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Little is known about the correlation between the melanocortin 4 receptor gene (MC4R) single nucleotide polymorphisms (SNPs) and the risk of obesity. This research sought to test the MC4R rs17782313, rs476828 and rs12970134 SNPs, their haplotypes and gene-environment interactions on the risk of obesity in the Maonan ethnic group, an isolated minority in China.
+
+ METHODS: A case-control study comprised of 1836 participants (obesity group, 858; and control group, 978) was conducted. Genotypes of the three SNPs were determined by the next-generation sequencing (NGS) technology.
+
+ RESULTS: The genotypic frequencies of the three SNPs were different between the obesity and control groups (P < 0.05 for all). The minor allelic frequency of the MC4R rs17782313C, rs476828C and rs12970134A was higher in obesity than in control groups (13.8% vs. 8.3%, P < 0.001, 17.1% vs. 10.9%, P < 0.001; and 15.5% vs. 11.5%, P < 0.001; respectively). Additionally, the dominant model of rs17782313 and rs476828 SNPs revealed an increased morbidity function on the risk of obesity (P < 0.05). A correlation between SNP-environment and the risk of obesity was also observed. The rs17782313C-rs476828C-rs12970134A haplotype was associated with high risk of obesity (OR = 1.796, 95% CI = 1.447-2.229), whereas the rs17782313T-rs476828T-rs12970134G and rs17782313T-rs476828T-rs12970134A haplotypes were associated with low risk of obesity (OR = 0.699, 95% CI = 0.586-0.834 and OR = 0.620, 95% CI = 0.416-0.925; respectively). The interactions between haplotype and waist circumference on the risk of obesity were also noted.
+
+ CONCLUSIONS: We discovered that the MC4R rs17782313, rs476828 and rs12970134 SNPs and their haplotypes were associated with the risk of obesity in the Chinese Maonan population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MC4R protein, human). 0 (Receptor, Melanocortin, Type 4).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs10020-020-00202-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wei&issn=1076-1551&title=Molecular+Medicine&atitle=The+MC4R+SNPs%2C+their+haplotypes+and+gene-environment+interactions+on+the+risk+of+obesity.&volume=26&issue=1&spage=77&epage=&date=2020&doi=10.1186%2Fs10020-020-00202-1&pmid=32770936&sid=OVID:medline
+
+<1226>
+Unique Identifier
+ 32763537
+Title
+ Interaction of FTO rs9939609 and the native American-origin ABCA1 p.Arg230Cys with circulating leptin levels in Mexican adolescents diagnosed with eating disorders: Preliminary results.
+Source
+ Psychiatry Research. 291:113270, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Genis-Mendoza AD; Martinez-Magana JJ; Ruiz-Ramos D; Gonzalez-Covarrubias V; Tovilla-Zarate CA; Narvaez MLL; Castro TBG; Juarez-Rojop IE; Nicolini H
+Authors Full Name
+ Genis-Mendoza, Alma Delia; Martinez-Magana, Jose Jaime; Ruiz-Ramos, David; Gonzalez-Covarrubias, Vanessa; Tovilla-Zarate, Carlos Alfonso; Narvaez, Mari Lilia Lopez; Castro, Thelma Beatriz Gonzalez; Juarez-Rojop, Isela Esther; Nicolini, Humberto.
+Institution
+ Genis-Mendoza, Alma Delia. Laboratorio de Genomica de Enfermedades Psiquiatricas y Neurodegenerativas, Instituto Nacional de Medicina Genomica, CDMX, Mexico; Hospital Psiquiatrico Infantil "Juan N. Navarro" Servicios de Administracion Psiquiatrica, CDMX, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico. Electronic address: adgenis@inmegen.gob.mx.
+ Martinez-Magana, Jose Jaime. Laboratorio de Genomica de Enfermedades Psiquiatricas y Neurodegenerativas, Instituto Nacional de Medicina Genomica, CDMX, Mexico; Division Academica Multidisciplinaria de Jalpa de Mendez, Universidad Juarez Autonoma de Tabasco, Jalpa de Mendez, Tabasco, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico.
+ Ruiz-Ramos, David. Laboratorio de Genomica de Enfermedades Psiquiatricas y Neurodegenerativas, Instituto Nacional de Medicina Genomica, CDMX, Mexico; Division Academica Multidisciplinaria de Jalpa de Mendez, Universidad Juarez Autonoma de Tabasco, Jalpa de Mendez, Tabasco, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico.
+ Gonzalez-Covarrubias, Vanessa. Laboratorio de Farmacogenomica, Instituto Nacional de Medicina Genomica, CDMX, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico.
+ Tovilla-Zarate, Carlos Alfonso. Division Academica Multidisciplinaria de Comalcalco, Universidad Juarez Autonoma de Tabasco, Comalcalco, Tabasco, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico.
+ Narvaez, Mari Lilia Lopez. Hospital General de Yajalon Dr. Manuel Velasco Siles. Secretaria de Salud de Chiapas. Yajalon, Chiapas, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico.
+ Castro, Thelma Beatriz Gonzalez. Division Academica Multidisciplinaria de Jalpa de Mendez, Universidad Juarez Autonoma de Tabasco, Jalpa de Mendez, Tabasco, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico.
+ Juarez-Rojop, Isela Esther. Hospital General de Yajalon Dr. Manuel Velasco Siles. Secretaria de Salud de Chiapas. Yajalon, Chiapas, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico.
+ Nicolini, Humberto. Laboratorio de Genomica de Enfermedades Psiquiatricas y Neurodegenerativas, Instituto Nacional de Medicina Genomica, CDMX, Mexico; Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico; Grupo de Estudios Medicos y Familiares Carracci, CDMX, Mexico. Electronic address: hnicolini@inmegen.gob.mx.
+MeSH Subject Headings
+ *ATP Binding Cassette Transporter 1/ge [Genetics]
+ Adolescent
+ *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/ge [Genetics]
+ Biomarkers/bl [Blood]
+ *Epistasis, Genetic/ge [Genetics]
+ Feeding and Eating Disorders/bl [Blood]
+ Feeding and Eating Disorders/di [Diagnosis]
+ *Feeding and Eating Disorders/ge [Genetics]
+ Female
+ Humans
+ Leptin/bl [Blood]
+ *Leptin/ge [Genetics]
+ Male
+ Mexico/ep [Epidemiology]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ge [Genetics]
+ Polymorphism, Single Nucleotide/ge [Genetics]
+ *American Indian or Alaska Native/ge [Genetics]
+Keyword Heading
+ ABCA1
+ FTO
+ Feeding and eating-disorders
+ Leptin
+ Mexican population
+ anxiety
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Eating disorders (ED) are characterized by disruption of eating behaviour and alteration of food intake. Leptin, is one of the main hormones that modulate food intake and are altered in individuals diagnosed with ED. Genetic risk variants for obesity, like those reported inFTO and ABCA1, have also been associated to ED disorders. The present study aimed to analysed leptin circulating levels and the interaction between obesity-risk variants in FTO and ABCA1, in adolescents diagnosed with ED. A total of 99 individuals diagnosed with ED were genotype using Taqman probes for FTO (rs9939609) and ABCA1 (p.Arg230Cys, rs9282541). Commercial enzyme-linked immunosorbent assays were utilized to determined circulating leptin. Differences in leptin concentration were analysed by t-Student or ANOVA test. Gene-gene interaction were analysed using general estimation equations. Circulating leptin levels differed between the three diagnostic groups, lead by individuals diagnosed with binge eating-disorder. In individuals with more than 3 of episodes of binge-eating per week having the highest leptin levels. Also, we found that carriers of both risk alleles had the highest leptin levels. Our observations found an interaction between FTO rs9969609 and the native American-origin ABCA1 p.Arg230Cys to modulate circulating leptin levels in Mexican adolescents diagnosed with eating-disorders. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ABCA1 protein, human). 0 (ATP Binding Cassette Transporter 1). 0 (Biomarkers). 0 (LEP protein, human). 0 (Leptin). EC 1-14-11-33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO). EC 1-14-11-33 (FTO protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.psychres.2020.113270
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Genis-Mendoza&issn=0165-1781&title=Psychiatry+Research&atitle=Interaction+of+FTO+rs9939609+and+the+native+American-origin+ABCA1+p.Arg230Cys+with+circulating+leptin+levels+in+Mexican+adolescents+diagnosed+with+eating+disorders%3A+Preliminary+results.&volume=291&issue=&spage=113270&epage=&date=2020&doi=10.1016%2Fj.psychres.2020.113270&pmid=32763537&sid=OVID:medline
+
+<1227>
+Unique Identifier
+ 32755834
+Title
+ Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study.
+Source
+ Diabetes & Metabolic Syndrome. 14(5):1347-1354, 2020 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Briones-Espinoza MJ; Cortes-Garcia JD; Vega-Cardenas M; Uresti-Rivera EU; Gomez-Otero A; Lopez-Lopez N; Mejia-Torres M; Portales-Perez DP
+Authors Full Name
+ Briones-Espinoza, Margarita J; Cortes-Garcia, Juan D; Vega-Cardenas, Mariela; Uresti-Rivera, Edith U; Gomez-Otero, Arturo; Lopez-Lopez, Nallely; Mejia-Torres, Manuel; Portales-Perez, Diana P.
+Institution
+ Briones-Espinoza, Margarita J. Translational and Molecular Medicine Laboratory, Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosi, Mexico.
+ Cortes-Garcia, Juan D. Translational and Molecular Medicine Laboratory, Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosi, Mexico.
+ Vega-Cardenas, Mariela. Translational and Molecular Medicine Laboratory, Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosi, Mexico.
+ Uresti-Rivera, Edith U. Translational and Molecular Medicine Laboratory, Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosi, Mexico.
+ Gomez-Otero, Arturo. Aesthetic and Corrective Plastic Surgery Clinic, San Luis Potosi, Mexico.
+ Lopez-Lopez, Nallely. Translational and Molecular Medicine Laboratory, Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosi, Mexico.
+ Mejia-Torres, Manuel. Translational and Molecular Medicine Laboratory, Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosi, Mexico.
+ Portales-Perez, Diana P. Translational and Molecular Medicine Laboratory, Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosi, Mexico. Electronic address: dportale@uaslp.mx.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pa [Pathology]
+ Adult
+ Biomarkers/an [Analysis]
+ Female
+ Follow-Up Studies
+ *Gene Expression Regulation
+ Humans
+ Male
+ *MicroRNAs/ge [Genetics]
+ Middle Aged
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Overweight/ge [Genetics]
+ Overweight/me [Metabolism]
+ *Overweight/pa [Pathology]
+ Pilot Projects
+ Prognosis
+ Sirtuin 1/ge [Genetics]
+ *Sirtuin 1/me [Metabolism]
+ Young Adult
+Keyword Heading
+ Metabolic targets
+ Obesity
+ Overweight
+ Sirtuin
+ microRNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Overweight and obesity are important risk factors for chronic disorders. Fat accumulation is one of the central manifestations; it occurs via a complex mechanism where multiple metabolic signals converge. Sirtuins are an enzyme family with deacetylase functions that are implicated in the regulation of several genes. Sirt1 and its upstream regulator (miR-34a) are elements of a converging mechanism that integrates the dynamic metabolic state. In this work, we hypothesized that elevated levels of miR-34a in overweight/obese group inhibits Sirt1 activity. Therefore, we studied the miR-34a/Sirt1 axis in mononuclear cells obtained from adipose tissue.
+
+ METHODS: Adipose tissue samples were collected from 36 subjects, and they were categorized according to body mass index (BMI) as overweight/obesity and normoweight. Subcutaneous adipose tissue samples were enzymatically dissociated, and mononuclear cells from adipose tissue were isolated by Ficoll Hypaque. Sirt1-positive cells and relative Sirt1 expression were determined by flow cytometry and real-time polymerase chain reaction (qPCR), respectively. Finally, Sirt1 activity was measured with a luminescence assay.
+
+ RESULTS: The percentage of Sirt1-positive mononuclear cells from adipose tissue decreased along with Sirt1 enzymatic activity in overweight/obese participants. miR-34a expression increased in the overweight/obese group compared to normoweight individuals. There was a negative association between the relative miR-34a expression and Sirt1-positive cells and a synergistic effect on Sirt1-positive cells mediated by the miR-34a inhibitor and Sirt1 agonist.
+
+ CONCLUSIONS: Our results describe for the first time the presence of miR-34a and Sirt1 in mononuclear cells isolated from subcutaneous adipose tissue. Additionally, these results suggest altered sirtuin function in overweight/obese patients and open the possibility for new therapies that involve these metabolic targets. Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN34 microRNA, human). 0 (MicroRNAs). EC 3-5-1 (SIRT1 protein, human). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.dsx.2020.07.014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Briones-Espinoza&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Decreased+levels+and+activity+of+Sirt1+are+modulated+by+increased+miR-34a+expression+in+adipose+tissue+mononuclear+cells+from+subjects+with+overweight+and+obesity%3A+A+pilot+study.&volume=14&issue=5&spage=1347&epage=1354&date=2020&doi=10.1016%2Fj.dsx.2020.07.014&pmid=32755834&sid=OVID:medline
+
+<1228>
+Unique Identifier
+ 32755613
+Title
+ The effects of astaxanthin supplementation on obesity, blood pressure, CRP, glycemic biomarkers, and lipid profile: A meta-analysis of randomized controlled trials.
+Source
+ Pharmacological Research. 161:105113, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xia W; Tang N; Kord-Varkaneh H; Low TY; Tan SC; Wu X; Zhu Y
+Authors Full Name
+ Xia, Wei; Tang, Nie; Kord-Varkaneh, Hamed; Low, Teck Yew; Tan, Shing Cheng; Wu, Xin; Zhu, Ying.
+Institution
+ Xia, Wei. Department of Endocrinology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China.
+ Tang, Nie. Department of Endocrinology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China.
+ Kord-Varkaneh, Hamed. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Low, Teck Yew. UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
+ Tan, Shing Cheng. UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
+ Wu, Xin. Heart Failure Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China. Electronic address: wuwucat5455@sina.com.
+ Zhu, Ying. Department of Endocrinology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China. Electronic address: zhuying_2004@163.com.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Blood Pressure/de [Drug Effects]
+ Body Mass Index
+ *C-Reactive Protein/me [Metabolism]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Dietary Supplements/ae [Adverse Effects]
+ *Dietary Supplements
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ *Dyslipidemias/dt [Drug Therapy]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Randomized Controlled Trials as Topic
+ Time Factors
+ Treatment Outcome
+ Xanthophylls/ae [Adverse Effects]
+ Xanthophylls/tu [Therapeutic Use]
+ Young Adult
+Keyword Heading
+ Astaxanthin
+ BMI
+ Blood pressure
+ CRP
+ Lipid profile
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: Previous studies lack consistent conclusions as to whether astaxanthin is actually linked to various health benefits as claimed. Here, we attempt to unravel the association of astaxanthin consumption with selected health benefits by performing a systematic review and meta-analysis.
+
+ METHODS: Online literature search databases including Scopus, Web of Science, PubMed/Medline, Embase and Google Scholar were searched to discover relevant articles available up to 17 March 2020. We used mean changes and SD of the outcomes to assess treatment response from baseline and mean difference, and 95 % CI were calculated to combined data and assessment effect sizes in astaxanthin and control groups.
+
+ RESULTS: 14 eligible articles were included in the final quantitative analysis. Current study revealed that astaxanthin consumption was not associated with FBS, HbA1c, TC, LDL-C, TG, BMI, BW, DBP, and SBP. We did observe an overall increase in HDL-C (WMD: 1.473 mg/dl, 95 % CI: 0.319-2.627, p = 0.012). As for the levels of CRP, only when astaxanthin was administered (i) for relatively long periods (>= 12 weeks) (WMD: -0.528 mg/l, 95 % CI: -0.990 to -0.066), and (ii) at high dose (> 12 mg/day) (WMD: -0.389 mg/dl, 95 % CI: -0.596 to -0.183), the levels of CRP would decrease.
+
+ CONCLUSION: In summary, our systematic review and meta-analysis revealed that astaxanthin consumption was associated with increase in HDL-C and decrease in CRP. Significant associations were not observed for other outcomes. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Lipids). 0 (Xanthophylls). 0 (hemoglobin A1c protein, human). 8XPW32PR7I (astaxanthine). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.phrs.2020.105113
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xia&issn=1043-6618&title=Pharmacological+Research&atitle=The+effects+of+astaxanthin+supplementation+on+obesity%2C+blood+pressure%2C+CRP%2C+glycemic+biomarkers%2C+and+lipid+profile%3A+A+meta-analysis+of+randomized+controlled+trials.&volume=161&issue=&spage=105113&epage=&date=2020&doi=10.1016%2Fj.phrs.2020.105113&pmid=32755613&sid=OVID:medline
+
+<1229>
+Unique Identifier
+ 32755126
+Title
+ Sleeve Gastrectomy in a Severe Hemophilia A Patient: One of the Very Rare Cases.
+Source
+ Turkish Journal of Haematology. 37(4):304-306, 2020 Nov 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Davulcu EA; Demirci Z; Firat O; Saydam G; Sahin F
+Author NameID
+ Davulcu, Eren Arslan; ORCID: https://orcid.org/0000-0001-9262-2883
+Authors Full Name
+ Davulcu, Eren Arslan; Demirci, Zuhal; Firat, Ozgur; Saydam, Guray; Sahin, Fahri.
+Institution
+ Davulcu, Eren Arslan. Ege University Medical Faculty, Hematology Department, Ege Adult Hemophilia and Thrombosis Center, Izmir, Turkey
+ Demirci, Zuhal. Ege University Medical Faculty, Hematology Department, Ege Adult Hemophilia and Thrombosis Center, Izmir, Turkey
+ Firat, Ozgur. Ege University Medical Faculty, Department of General Surgery, Izmir, Turkey
+ Saydam, Guray. Ege University Medical Faculty, Hematology Department, Ege Adult Hemophilia and Thrombosis Center, Izmir, Turkey
+ Sahin, Fahri. Ege University Medical Faculty, Hematology Department, Ege Adult Hemophilia and Thrombosis Center, Izmir, Turkey
+MeSH Subject Headings
+ Biomarkers
+ Disease Management
+ Gastrectomy/ae [Adverse Effects]
+ Gastrectomy/mt [Methods]
+ *Gastrectomy
+ *Hemophilia A/co [Complications]
+ Hemophilia A/di [Diagnosis]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity/su [Surgery]
+ Overweight
+ Severity of Illness Index
+ Treatment Outcome
+Keyword Heading
+ Hemophilia A
+ Obesity
+ Bariatric surgery
+Keyword Heading Owner
+ NOTNLM
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Case Reports. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.4274%2ftjh.galenos.2020.2020.0168
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Davulcu&issn=1300-7777&title=Turkish+Journal+of+Haematology&atitle=Sleeve+Gastrectomy+in+a+Severe+Hemophilia+A+Patient%3A+One+of+the+Very+Rare+Cases.&volume=37&issue=4&spage=304&epage=306&date=2020&doi=10.4274%2Ftjh.galenos.2020.2020.0168&pmid=32755126&sid=OVID:medline
+
+<1230>
+Unique Identifier
+ 32752280
+Title
+ Goat's Milk Intake Prevents Obesity, Hepatic Steatosis and Insulin Resistance in Mice Fed A High-Fat Diet by Reducing Inflammatory Markers and Increasing Energy Expenditure and Mitochondrial Content in Skeletal Muscle.
+Source
+ International Journal of Molecular Sciences. 21(15), 2020 Aug 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Delgadillo-Puga C; Noriega LG; Morales-Romero AM; Nieto-Camacho A; Granados-Portillo O; Rodriguez-Lopez LA; Aleman G; Furuzawa-Carballeda J; Tovar AR; Cisneros-Zevallos L; Torre-Villalvazo I
+Author NameID
+ Delgadillo-Puga, Claudia; ORCID: https://orcid.org/0000-0003-3506-754X
+ Noriega, Lilia G; ORCID: https://orcid.org/0000-0003-2156-9872
+ Furuzawa-Carballeda, Janette; ORCID: https://orcid.org/0000-0001-5804-7221
+ Torre-Villalvazo, Ivan; ORCID: https://orcid.org/0000-0001-7412-1153
+Authors Full Name
+ Delgadillo-Puga, Claudia; Noriega, Lilia G; Morales-Romero, Aurora M; Nieto-Camacho, Antonio; Granados-Portillo, Omar; Rodriguez-Lopez, Leonardo A; Aleman, Gabriela; Furuzawa-Carballeda, Janette; Tovar, Armando R; Cisneros-Zevallos, Luis; Torre-Villalvazo, Ivan.
+Institution
+ Delgadillo-Puga, Claudia. Departamento de Nutricion Animal Dr. Fernando Perez-Gil Romo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
+ Noriega, Lilia G. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
+ Morales-Romero, Aurora M. Facultad de Quimica, Universidad Nacional Autonoma de Mexico (UNAM), Ciudad de Mexico 04510, Mexico.
+ Nieto-Camacho, Antonio. Instituto de Quimica, Universidad Nacional Autonoma de Mexico (UNAM), Ciudad de Mexico 04510, Mexico.
+ Granados-Portillo, Omar. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
+ Rodriguez-Lopez, Leonardo A. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
+ Aleman, Gabriela. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
+ Furuzawa-Carballeda, Janette. Departamento de Inmunologia y Reumatologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
+ Tovar, Armando R. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
+ Cisneros-Zevallos, Luis. Department of Horticultural Sciences, Texas A&M University, College Station, TX 77843-2133, USA.
+ Cisneros-Zevallos, Luis. Department of Nutrition and Food Science, Texas A&M University, College Station, TX 77843, USA.
+ Torre-Villalvazo, Ivan. Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
+MeSH Subject Headings
+ Animals
+ Biomarkers/an [Analysis]
+ Diet, High-Fat/ae [Adverse Effects]
+ Dietary Supplements
+ *Energy Metabolism/de [Drug Effects]
+ *Fatty Acids/ad [Administration & Dosage]
+ Fatty Liver/et [Etiology]
+ *Fatty Liver/pc [Prevention & Control]
+ Gene Expression/de [Drug Effects]
+ Goats
+ Insulin Resistance
+ Linoleic Acids, Conjugated/ad [Administration & Dosage]
+ Male
+ Mice, Inbred C57BL
+ *Milk/ch [Chemistry]
+ *Mitochondria, Muscle/de [Drug Effects]
+ Mitochondria, Muscle/me [Metabolism]
+ *Muscle, Skeletal/de [Drug Effects]
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/et [Etiology]
+ *Obesity/pc [Prevention & Control]
+Keyword Heading
+ Acacia farnesiana
+ adipose tissue browning
+ bioactive compounds
+ energy expenditure
+ functional food
+ goat's milk
+ grazing
+ polyphenols
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Goat's milk is a rich source of bioactive compounds (peptides, conjugated linoleic acid, short chain fatty acids, monounsaturated and polyunsaturated fatty acids, polyphenols such as phytoestrogens and minerals among others) that exert important health benefits. However, goat's milk composition depends on the type of food provided to the animal and thus, the abundance of bioactive compounds in milk depends on the dietary sources of the goat feed. The metabolic impact of goat milk rich in bioactive compounds during metabolic challenges such as a high-fat (HF) diet has not been explored. Thus, we evaluated the effect of milk from goats fed a conventional diet, a conventional diet supplemented with 30% Acacia farnesiana (AF) pods or grazing on metabolic alterations in mice fed a HF diet. Interestingly, the incorporation of goat's milk in the diet decreased body weight and body fat mass, improved glucose tolerance, prevented adipose tissue hypertrophy and hepatic steatosis in mice fed a HF diet. These effects were associated with an increase in energy expenditure, augmented oxidative fibers in skeletal muscle, and reduced inflammatory markers. Consequently, goat's milk can be considered a non-pharmacologic strategy to improve the metabolic alterations induced by a HF diet. Using the body surface area normalization method gave a conversion equivalent daily human intake dose of 1.4 to 2.8 glasses (250 mL per glass/day) of fresh goat milk for an adult of 60 kg, which can be used as reference for future clinical studies.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids). 0 (Linoleic Acids, Conjugated).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21155530
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Delgadillo-Puga&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Goat%27s+Milk+Intake+Prevents+Obesity%2C+Hepatic+Steatosis+and+Insulin+Resistance+in+Mice+Fed+A+High-Fat+Diet+by+Reducing+Inflammatory+Markers+and+Increasing+Energy+Expenditure+and+Mitochondrial+Content+in+Skeletal+Muscle.&volume=21&issue=15&spage=5530&epage=&date=2020&doi=10.3390%2Fijms21155530&pmid=32752280&sid=OVID:medline
+
+<1231>
+Unique Identifier
+ 32745698
+Title
+ Screening strategies for nonalcoholic fatty liver disease in type 2 diabetes: Insights from NHANES 2005-2016.
+Source
+ Diabetes Research & Clinical Practice. 167:108358, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ciardullo S; Sala I; Perseghin G
+Authors Full Name
+ Ciardullo, Stefano; Sala, Isabella; Perseghin, Gianluca.
+Institution
+ Ciardullo, Stefano. Department of Medicine and Rehabilitation, Policlinico di Monza, Italy; Department of Medicine and Surgery, University of Milano Bicocca, Italy. Electronic address: s.ciardullo@campus.unimib.it.
+ Sala, Isabella. Department of Statistics and Quantitative Methods, University of Milano Bicocca, Italy. Electronic address: i.sala@campus.unimib.it.
+ Perseghin, Gianluca. Department of Medicine and Rehabilitation, Policlinico di Monza, Italy; Department of Medicine and Surgery, University of Milano Bicocca, Italy. Electronic address: gianluca.perseghin@policlinicodimonza.it.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aspartate Aminotransferases/bl [Blood]
+ Biomarkers/bl [Blood]
+ Biopsy
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ Humans
+ Liver Cirrhosis/di [Diagnosis]
+ *Liver Cirrhosis/ep [Epidemiology]
+ Male
+ Mass Screening
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ *Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Nutrition Surveys
+ Obesity/ep [Epidemiology]
+ Practice Guidelines as Topic
+ Prevalence
+ Referral and Consultation
+ United States
+Keyword Heading
+ Guidelines
+ Liver fibrosis
+ NAFLD
+ Referral
+ T2DM
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Nonalcoholic fatty liver disease (NAFLD) is prevalent in patients with type 2 diabetes mellitus (T2DM), but controversy exists on whether to screen and how to manage these patients in clinical practice. Here, we estimate the number of patients with T2DM and NAFLD in the United States that should be evaluated for advanced liver fibrosis according to proposed screening strategies.
+
+ METHODS: In this cross-sectional analysis of 2940 adult patients with T2DM (projected to 15.3 million) from the 2005-2016 National Health and Nutrition Examination Survey (NHANES) we applied validated noninvasive scores of liver steatosis and fibrosis to estimate the number of referrals to hepatologists. We followed two different approaches: (1) the flow-chart from the European Association for the Study of the Liver (EASL), Diabetes (EASD) and Obesity (EASO) guidelines; (2) a strategy recently proposed in patients with T2DM aimed at excluding advanced liver fibrosis with a negative predictive value of 100%.
+
+ RESULTS: NAFLD (based on fatty liver index) was present in 78% of patients (projected to 11.9 million). According to the EASL-EASD-EASO guidelines 37.2-48.5% of patients (projected to 5.7-7.4 million) should be referred to experts, depending on the specific biomarker of fibrosis used. The second strategy, which is based sequentially on aspartate aminotransferase and Fibrosis-4 was able to exclude advanced fibrosis in 67.0% of patients.
+
+ CONCLUSIONS: Screening strategies based on noninvasive scores are able to exclude advanced liver fibrosis in 50-67% of patients with T2DM. Novel biomarkers or combination of tests may be necessary to reduce the need for liver biopsy and related bleeding episodes in the remaining 33-50%. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-1 (Aspartate Aminotransferases).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.diabres.2020.108358
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ciardullo&issn=0168-8227&title=Diabetes+Research+%26+Clinical+Practice&atitle=Screening+strategies+for+nonalcoholic+fatty+liver+disease+in+type+2+diabetes%3A+Insights+from+NHANES+2005-2016.&volume=167&issue=&spage=108358&epage=&date=2020&doi=10.1016%2Fj.diabres.2020.108358&pmid=32745698&sid=OVID:medline
+
+<1232>
+Unique Identifier
+ 32740758
+Title
+ The Impact of Obesity on Disease Activity and Treatment Response in Rheumatoid Arthritis. [Review]
+Source
+ Current Rheumatology Reports. 22(9):56, 2020 08 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Poudel D; George MD; Baker JF
+Author NameID
+ Poudel, Dilli; ORCID: https://orcid.org/0000-0003-2350-719X
+ George, Michael D; ORCID: https://orcid.org/0000-0002-0398-2308
+ Baker, Joshua F; ORCID: https://orcid.org/0000-0003-0799-7563
+Authors Full Name
+ Poudel, Dilli; George, Michael D; Baker, Joshua F.
+Institution
+ Poudel, Dilli. Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.
+ George, Michael D. Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.
+ George, Michael D. Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
+ Baker, Joshua F. Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA. Joshua.Baker@pennmedicine.upenn.edu.
+ Baker, Joshua F. Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA. Joshua.Baker@pennmedicine.upenn.edu.
+ Baker, Joshua F. Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. Joshua.Baker@pennmedicine.upenn.edu.
+ Baker, Joshua F. Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, 5 White Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA. Joshua.Baker@pennmedicine.upenn.edu.
+MeSH Subject Headings
+ Arthritis, Rheumatoid/co [Complications]
+ Arthritis, Rheumatoid/dt [Drug Therapy]
+ *Arthritis, Rheumatoid
+ Biomarkers
+ Humans
+ Obesity/co [Complications]
+ *Obesity
+ Treatment Outcome
+Keyword Heading
+ Adiposity
+ Body mass index
+ Obesity
+ Rheumatoid arthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE OF THE REVIEW: A growing number of studies have suggested that disease outcomes and response to therapy may be different in patients with rheumatoid arthritis (RA) who are obese. The goal of this review is to examine the most recent literature, with a focus on the impact of obesity on the assessment of disease activity and treatment outcomes in RA.
+
+ RECENT FINDINGS: Obesity is common in patients with RA and can have a substantial impact on patient symptoms and outcomes. Obesity is associated with higher rates of chronic pain and opiate use, elevated inflammatory markers, and less reliable physical exam findings, making assessment of disease activity and treatment response more challenging. Despite seemingly worse clinical disease activity, evidence has accumulated demonstrating that obese patients with RA have less inflammation by imaging and lower rates of radiographic progression over time. Whether obesity influences the effectiveness of specific therapies remains controversial. Obesity is very common and is associated with more severe symptoms and higher rates of disability among RA patients. While clinical disease activity is frequently observed to be higher in obese patients with RA, it remains unclear whether poorer treatment response rates in this setting are related to reduced efficacy of therapies or are an artifact of biases in the accurate assessment of the disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, U.S. Gov't, Non-P.H.S.. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs11926-020-00933-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Poudel&issn=1523-3774&title=Current+Rheumatology+Reports&atitle=The+Impact+of+Obesity+on+Disease+Activity+and+Treatment+Response+in+Rheumatoid+Arthritis.&volume=22&issue=9&spage=56&epage=&date=2020&doi=10.1007%2Fs11926-020-00933-4&pmid=32740758&sid=OVID:medline
+
+<1233>
+Unique Identifier
+ 32739259
+Title
+ Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance.
+Source
+ EBioMedicine. 59:102912, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Arcidiacono B; Chiefari E; Foryst-Ludwig A; Curro G; Navarra G; Brunetti FS; Mirabelli M; Corigliano DM; Kintscher U; Britti D; Mollace V; Foti DP; Goldfine ID; Brunetti A
+Authors Full Name
+ Arcidiacono, Biagio; Chiefari, Eusebio; Foryst-Ludwig, Anna; Curro, Giuseppe; Navarra, Giuseppe; Brunetti, Francesco S; Mirabelli, Maria; Corigliano, Domenica M; Kintscher, Ulrich; Britti, Domenico; Mollace, Vincenzo; Foti, Daniela P; Goldfine, Ira D; Brunetti, Antonio.
+Institution
+ Arcidiacono, Biagio. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Chiefari, Eusebio. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Foryst-Ludwig, Anna. Institute of Pharmacology, Center for Cardiovascular Research, Charite Universitatsmedizin, 10115 Berlin, Germany.
+ Curro, Giuseppe. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Navarra, Giuseppe. Department of Human Pathology of Adult and Evolutive Age, University Hospital of Messina, 98122 Messina, Italy.
+ Brunetti, Francesco S. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Mirabelli, Maria. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Corigliano, Domenica M. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Kintscher, Ulrich. Institute of Pharmacology, Center for Cardiovascular Research, Charite Universitatsmedizin, 10115 Berlin, Germany.
+ Britti, Domenico. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Mollace, Vincenzo. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Foti, Daniela P. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy.
+ Goldfine, Ira D. Department of Medicine, University of California San Francisco, 94143 San Francisco, USA.
+ Brunetti, Antonio. Department of Health Sciences, University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy. Electronic address: brunetti@unicz.it.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Aged
+ Animals
+ Biomarkers
+ Body Mass Index
+ Cell Line
+ Comorbidity
+ Disease Models, Animal
+ Female
+ Gene Expression Regulation
+ Glucose/me [Metabolism]
+ Humans
+ *Hypoxia/ge [Genetics]
+ *Hypoxia/me [Metabolism]
+ *Insulin Resistance/ge [Genetics]
+ Male
+ Mice
+ *MicroRNAs/ge [Genetics]
+ Middle Aged
+ *Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ RNA Interference
+ *Receptor, Insulin/ge [Genetics]
+ Receptor, Insulin/me [Metabolism]
+Keyword Heading
+ Adipose-tissue dysfunction
+ Hypoxia
+ Insulin receptor
+ Insulin resistance
+ Obesity
+ mRNA decay
+ miRNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Insulin resistance in visceral adipose tissue (VAT), skeletal muscle and liver is a prominent feature of most patients with obesity. How this association arises remains poorly understood. The objective of this study was to demonstrate that the decrease in insulin receptor (INSR) expression and insulin signaling in VAT from obese individuals is an early molecular manifestation that might play a crucial role in the cascade of events leading to systemic insulin resistance.
+
+ METHODS: To clarify the role of INSR and insulin signaling in adipose tissue dysfunction in obesity, we first measured INSR expression in VAT samples from normal-weight subjects and patients with different degrees of obesity. We complemented these studies with experiments on high-fat diet (HFD)-induced obese mice, and in human and murine adipocyte cultures, in both normoxic and hypoxic conditions.
+
+ FINDINGS: An inverse correlation was observed between increasing body mass index and decreasing INSR expression in VAT of obese humans. Our results indicate that VAT-specific downregulation of INSR is an early event in obesity-related adipose cell dysfunction, which increases systemic insulin resistance in both obese humans and mice. We also provide evidence that obesity-related hypoxia in VAT plays a determinant role in this scenario by decreasing INSR mRNA stability. This decreased stability is through the activation of a miRNA (miR-128) that downregulates INSR expression in adipocytes.
+
+ INTERPRETATION: We present a novel pathogenic mechanism of reduced INSR expression and insulin signaling in adipocytes. Our data provide a new explanation linking obesity with systemic insulin resistance.
+
+ FUNDING: This work was partly supported by a grant from Nutramed (PON 03PE000_78_1) and by the European Commission (FESR FSE 2014-2020 and Regione Calabria). Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN128 microRNA, human). 0 (MicroRNAs). EC 2-7-10-1 (Receptor, Insulin). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.ebiom.2020.102912
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Arcidiacono&issn=2352-3964&title=EBioMedicine&atitle=Obesity-related+hypoxia+via+miR-128+decreases+insulin-receptor+expression+in+human+and+mouse+adipose+tissue+promoting+systemic+insulin+resistance.&volume=59&issue=&spage=102912&epage=&date=2020&doi=10.1016%2Fj.ebiom.2020.102912&pmid=32739259&sid=OVID:medline
+
+<1234>
+Unique Identifier
+ 32738021
+Title
+ Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes.
+Source
+ Pediatric Diabetes. 21(7):1126-1131, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Semova I; Levenson AE; Krawczyk J; Bullock K; Williams KA; Wadwa RP; Khoury PR; Kimball TR; Urbina EM; de Ferranti SD; Maahs DM; Dolan LM; Shah AS; Clish CB; Biddinger SB
+Author NameID
+ Semova, Ivana; ORCID: https://orcid.org/0000-0002-9754-1940
+ Wadwa, R Paul; ORCID: https://orcid.org/0000-0002-4139-2122
+Authors Full Name
+ Semova, Ivana; Levenson, Amy E; Krawczyk, Joanna; Bullock, Kevin; Williams, Kathryn A; Wadwa, R Paul; Khoury, Philip R; Kimball, Thomas R; Urbina, Elaine M; de Ferranti, Sarah D; Maahs, David M; Dolan, Lawrence M; Shah, Amy S; Clish, Clary B; Biddinger, Sudha B.
+Institution
+ Semova, Ivana. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
+ Levenson, Amy E. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
+ Krawczyk, Joanna. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
+ Bullock, Kevin. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
+ Williams, Kathryn A. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
+ Williams, Kathryn A. Biostatistics and Research Design Center, Boston Children's Hospital, Boston, Massachusetts, USA.
+ Wadwa, R Paul. Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.
+ Khoury, Philip R. Division of Cardiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA.
+ Kimball, Thomas R. Division of Cardiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA.
+ Urbina, Elaine M. Heart Institute, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA.
+ de Ferranti, Sarah D. Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
+ Maahs, David M. Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.
+ Dolan, Lawrence M. Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA.
+ Shah, Amy S. Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA.
+ Clish, Clary B. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
+ Biddinger, Sudha B. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers
+ Body Mass Index
+ Case-Control Studies
+ Cholesterol/aa [Analogs & Derivatives]
+ Cholesterol/bl [Blood]
+ *Cholesterol/me [Metabolism]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Humans
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Phytosterols/bl [Blood]
+ Sitosterols/bl [Blood]
+ Young Adult
+Keyword Heading
+ cardiovascular disease risk
+ cholesterol synthesis
+ type 2 diabetes
+ youth
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Changes in cholesterol absorption and cholesterol synthesis may promote dyslipidemia and cardiovascular disease in individuals with type 2 diabetes mellitus (T2DM).
+
+ OBJECTIVE: To assess cholesterol synthesis and absorption in lean individuals, obese individuals, and individuals with T2DM.
+
+ METHODS: We measured lathosterol and lanosterol (markers of cholesterol synthesis) as well as campesterol and beta-sitosterol (markers of cholesterol absorption) in the serum of 15 to 26 years old individuals with T2DM (n = 95), as well as their lean (n = 98) and obese (n = 92) controls.
+
+ RESULTS: Individuals with T2DM showed a 51% increase in lathosterol and a 65% increase in lanosterol compared to lean controls. Similarly, obese individuals showed a 31% increase in lathosterol compared to lean controls. Lathosterol and lanosterol were positively correlated with body mass index, fasting insulin and glucose, serum triglycerides, and C-reactive protein, and negatively correlated with HDL-cholesterol. In contrast, campesterol and beta-sitosterol were not altered in individuals with T2DM. Moreover, campesterol and beta-sitosterol were negatively correlated with body mass index, fasting insulin, and C-reactive protein and were positively correlated with HDL-cholesterol.
+
+ CONCLUSIONS: Adolescents and young adults with T2DM show evidence of increased cholesterol synthesis compared to non-diabetic lean controls. These findings suggest that T2DM may promote cardiovascular disease by increasing cholesterol synthesis, and provide additional rationale for the use of cholesterol synthesis inhibitors in this group. Copyright © 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phytosterols). 0 (Sitosterols). 5L5O665639 (campesterol). 5LI01C78DD (gamma-sitosterol). 80-99-9 (lathosterol). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fpedi.13097
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Semova&issn=1399-543X&title=Pediatric+Diabetes&atitle=Markers+of+cholesterol+synthesis+are+elevated+in+adolescents+and+young+adults+with+type+2+diabetes.&volume=21&issue=7&spage=1126&epage=1131&date=2020&doi=10.1111%2Fpedi.13097&pmid=32738021&sid=OVID:medline
+
+<1235>
+Unique Identifier
+ 32733386
+Title
+ MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort.
+Source
+ Frontiers in Endocrinology. 11:437, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hammad MM; Abu-Farha M; Hebbar P; Cherian P; Al Khairi I; Melhem M; Alkayal F; Alsmadi O; Thanaraj TA; Al-Mulla F; Abubaker J
+Authors Full Name
+ Hammad, Maha M; Abu-Farha, Mohamed; Hebbar, Prashantha; Cherian, Preethi; Al Khairi, Irina; Melhem, Motasem; Alkayal, Fadi; Alsmadi, Osama; Thanaraj, Thangavel Alphonse; Al-Mulla, Fahd; Abubaker, Jehad.
+Institution
+ Hammad, Maha M. Research Division, Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Abu-Farha, Mohamed. Research Division, Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Hebbar, Prashantha. Research Division, Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Cherian, Preethi. Research Division, Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al Khairi, Irina. Research Division, Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Melhem, Motasem. Research Division, Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Alkayal, Fadi. Research Division, Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Alkayal, Fadi. Department of Human Genetics, McGill University, Montreal, QC, Canada.
+ Alsmadi, Osama. King Hussein Cancer Center, Amman, Jordan.
+ Thanaraj, Thangavel Alphonse. Research Division, Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al-Mulla, Fahd. Research Division, Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Abubaker, Jehad. Research Division, Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Cohort Studies
+ *Cytokines/bl [Blood]
+ Female
+ Genetic Predisposition to Disease
+ *Ghrelin/bl [Blood]
+ *HSP40 Heat-Shock Proteins/bl [Blood]
+ Humans
+ Hypertension/bl [Blood]
+ *Hypertension/ep [Epidemiology]
+ Hypertension/ge [Genetics]
+ Hypertension/pa [Pathology]
+ Kuwait/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Nicotinamide Phosphoribosyltransferase/bl [Blood]
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ *Polymorphism, Single Nucleotide
+ Prognosis
+ *Receptor, Melanocortin, Type 4/ge [Genetics]
+ *rab GTP-Binding Proteins/bl [Blood]
+Keyword Heading
+ DNAJC27
+ MC4R
+ cAMP
+ ghrelin
+ obesity
+ visfatin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Melanocortin 4 receptor (MC4R), a notable component of the melanocortin system, regulates appetite, body weight, and energy homeostasis. Genome-wide association studies have identified several MC4R variants associated with adiposity; of these, rs17782313, which is associated with increased body mass index (BMI) and overeating behavior, is of particular interest. Another gene associated with increased adiposity in global genome-wide association studies is DNAJC27, a heat shock protein known to be elevated in obesity. The detailed mechanisms underlying the role of MC4R variants in the biological pathways underlying metabolic disorders are not well-understood. To address this, we assessed variations of rs17782313 in a cohort of 282 Arab individuals from Kuwait, who are deeply phenotyped for anthropometric and metabolic traits and various biomarkers, including DNAJC27. Association tests showed that the rs17782313_C allele was associated with BMI and DNAJC27 levels. Increased levels of DNAJC27 reduced the MC4R-mediated formation of cAMP in MC4R ACTOne stable cells. In conclusion, this study demonstrated an association between the rs17782313 variant near MC4R and increased BMI and DNAJC27 levels and established a link between increased DNAJC27 levels and lower cAMP levels. We propose that regulation of MC4R activity by DNAJC27 enhances appetite through its effect on cAMP, thereby regulating obesity. Copyright © 2020 Hammad, Abu-Farha, Hebbar, Cherian, Al Khairi, Melhem, Alkayal, Alsmadi, Thanaraj, Al-Mulla and Abubaker.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Ghrelin). 0 (HSP40 Heat-Shock Proteins). 0 (MC4R protein, human). 0 (Receptor, Melanocortin, Type 4). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase). EC 2-4-2-12 (nicotinamide phosphoribosyltransferase, human). EC 3-6-1 (DNAJC27 protein, human). EC 3-6-5-2 (rab GTP-Binding Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffendo.2020.00437
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hammad&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=MC4R+Variant+rs17782313+Associates+With+Increased+Levels+of+DNAJC27%2C+Ghrelin%2C+and+Visfatin+and+Correlates+With+Obesity+and+Hypertension+in+a+Kuwaiti+Cohort.&volume=11&issue=&spage=437&epage=&date=2020&doi=10.3389%2Ffendo.2020.00437&pmid=32733386&sid=OVID:medline
+
+<1236>
+Unique Identifier
+ 32731119
+Title
+ Osteocalcin and osteoprotegerin levels and their relationship with adipokines and proinflammatory cytokines in children with nonalcoholic fatty liver disease.
+Source
+ Cytokine. 135:155215, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ El Amrousy D; El-Afify D
+Authors Full Name
+ El Amrousy, Doaa; El-Afify, Dalia.
+Institution
+ El Amrousy, Doaa. Pediatric Department, Faculty of Medicine, Tanta University, Egypt. Electronic address: doaa.moha@med.tanta.edu.eg.
+ El-Afify, Dalia. Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Egypt.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adiponectin/bl [Blood]
+ Alanine Transaminase/bl [Blood]
+ Aspartate Aminotransferases/bl [Blood]
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ Child
+ *Cytokines/bl [Blood]
+ Humans
+ *Inflammation/bl [Blood]
+ Insulin/bl [Blood]
+ Insulin Resistance/ph [Physiology]
+ Interleukin-6/bl [Blood]
+ Male
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Obesity/bl [Blood]
+ *Osteocalcin/bl [Blood]
+ *Osteoprotegerin/bl [Blood]
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ Adipokines
+ Children
+ Cytokines
+ IL-6
+ Leptin
+ NAFLD
+ Osteocalcin
+ Osteoprotegerin
+ TNF-alpha
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To investigate the relationship between osteocalcin and osteoprotegerin as bone markers and inflammatory biomarkers such as adiponectin, leptin, tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) in children with nonalcoholic fatty liver disease (NAFLD).
+
+ METHODS: This study included 40 obese children with NAFLD as the patient group and 40 healthy obese children of matched age, sex and BMI as the control group. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting blood glucose, fasting insulin, Homeostatic model assessment method of insulin resistance (HOMA-IR), lipid profile, osteocalcin, osteoprotegerin, adiponectin, leptin, TNF-alpha, and IL-6 were measured in all participants.
+
+ RESULTS: Children with NAFLD had a significant decrease in osteocalcin, osteoprotegerin and adiponectin level with a significant increase in TNF-alpha and IL-6 levels. We also found a significant positive correlation between osteocalcin level and adiponectin levels but a significant negative correlation of osteocalcin with each of leptin and TNF-alpha. However, there was a significant negative correlation between osteoprotegerin levels and both TNF-alpha and IL-6 levels. Moreover, adiponectin and TNF-alpha were significant predictors for osteocalcin, and IL-6 was a significant predictor for osteoprotegerin.
+
+ CONCLUSION: Adiponectin, leptin, TNF-alpha, and IL-6 have potential association with the changes of osteocalcin and osteoprotegerin levels in children with NAFLD. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Cytokines). 0 (Insulin). 0 (Interleukin-6). 0 (Osteoprotegerin). 0 (Tumor Necrosis Factor-alpha). 104982-03-8 (Osteocalcin). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.cyto.2020.155215
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=El+Amrousy&issn=1043-4666&title=Cytokine&atitle=Osteocalcin+and+osteoprotegerin+levels+and+their+relationship+with+adipokines+and+proinflammatory+cytokines+in+children+with+nonalcoholic+fatty+liver+disease.&volume=135&issue=&spage=155215&epage=&date=2020&doi=10.1016%2Fj.cyto.2020.155215&pmid=32731119&sid=OVID:medline
+
+<1237>
+Unique Identifier
+ 32726151
+Title
+ Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection : A Retrospective Cohort Study.
+Source
+ Annals of Internal Medicine. 173(10):782-790, 2020 11 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Anderson MR; Geleris J; Anderson DR; Zucker J; Nobel YR; Freedberg D; Small-Saunders J; Rajagopalan KN; Greendyk R; Chae SR; Natarajan K; Roh D; Edwin E; Gallagher D; Podolanczuk A; Barr RG; Ferrante AW; Baldwin MR
+Author NameID
+ Anderson, Michaela R; ORCID: https://orcid.org/0000-0001-9274-7643
+ Anderson, David R; ORCID: https://orcid.org/0000-0002-1128-6206
+ Nobel, Yael R; ORCID: https://orcid.org/0000-0001-5759-3730
+ Freedberg, Daniel; ORCID: https://orcid.org/0000-0003-2023-2899
+ Small-Saunders, Jennifer; ORCID: https://orcid.org/0000-0001-6064-2249
+ Chae, Sae-Rom; ORCID: https://orcid.org/0000-0001-5404-7558
+ Natarajan, Karthik; ORCID: https://orcid.org/0000-0002-9066-9431
+ Gallagher, Dympna; ORCID: https://orcid.org/0000-0003-1769-9754
+ Podolanczuk, Anna; ORCID: https://orcid.org/0000-0002-9559-1485
+Authors Full Name
+ Anderson, Michaela R; Geleris, Joshua; Anderson, David R; Zucker, Jason; Nobel, Yael R; Freedberg, Daniel; Small-Saunders, Jennifer; Rajagopalan, Kartik N; Greendyk, Richard; Chae, Sae-Rom; Natarajan, Karthik; Roh, David; Edwin, Ethan; Gallagher, Dympna; Podolanczuk, Anna; Barr, R Graham; Ferrante, Anthony W; Baldwin, Matthew R.
+Institution
+ Anderson, Michaela R. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Geleris, Joshua. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Anderson, David R. Villanova School of Business, Villanova University, Villanova, Pennsylvania (D.R.A.).
+ Zucker, Jason. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Nobel, Yael R. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Freedberg, Daniel. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Small-Saunders, Jennifer. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Rajagopalan, Kartik N. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Greendyk, Richard. NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York (R.G.).
+ Chae, Sae-Rom. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Natarajan, Karthik. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Roh, David. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Edwin, Ethan. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Gallagher, Dympna. Institute of Human Nutrition, Columbia University Irving Medical Center, New York, New York (D.G.).
+ Podolanczuk, Anna. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Barr, R Graham. Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York (R.G.B.).
+ Ferrante, Anthony W. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+ Baldwin, Matthew R. Columbia University Irving Medical Center, New York, New York (M.R.A., J.G., J.Z., Y.R.N., D.F., J.S., K.N.R., S.C., K.N., D.R., E.E., A.P., A.W.F., M.R.B.).
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Academic Medical Centers
+ Age Factors
+ Aged
+ *Betacoronavirus
+ Biomarkers/bl [Blood]
+ Blood Sedimentation
+ *Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ COVID-19
+ Cohort Studies
+ *Coronavirus Infections/ep [Epidemiology]
+ Female
+ Fibrin Fibrinogen Degradation Products/an [Analysis]
+ Hospitalization
+ Hospitals, Community
+ Humans
+ *Intubation, Intratracheal/sn [Statistics & Numerical Data]
+ Length of Stay/sn [Statistics & Numerical Data]
+ Male
+ Middle Aged
+ New York City/ep [Epidemiology]
+ *Obesity/ep [Epidemiology]
+ Pandemics
+ *Pneumonia, Viral/ep [Epidemiology]
+ Proportional Hazards Models
+ Retrospective Studies
+ SARS-CoV-2
+ Troponin/bl [Blood]
+Abstract
+ BACKGROUND: Obesity is a risk factor for pneumonia and acute respiratory distress syndrome.
+
+ OBJECTIVE: To determine whether obesity is associated with intubation or death, inflammation, cardiac injury, or fibrinolysis in coronavirus disease 2019 (COVID-19).
+
+ DESIGN: Retrospective cohort study.
+
+ SETTING: A quaternary academic medical center and community hospital in New York City.
+
+ PARTICIPANTS: 2466 adults hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection over a 45-day period with at least 47 days of in-hospital observation.
+
+ MEASUREMENTS: Body mass index (BMI), admission biomarkers of inflammation (C-reactive protein [CRP] level and erythrocyte sedimentation rate [ESR]), cardiac injury (troponin level), and fibrinolysis (D-dimer level). The primary end point was a composite of intubation or death in time-to-event analysis.
+
+ RESULTS: Over a median hospital length of stay of 7 days (interquartile range, 3 to 14 days), 533 patients (22%) were intubated, 627 (25%) died, and 59 (2%) remained hospitalized. Compared with overweight patients, patients with obesity had higher risk for intubation or death, with the highest risk among those with class 3 obesity (hazard ratio, 1.6 [95% CI, 1.1 to 2.1]). This association was primarily observed among patients younger than 65 years and not in older patients (P for interaction by age = 0.042). Body mass index was not associated with admission levels of biomarkers of inflammation, cardiac injury, or fibrinolysis.
+
+ LIMITATIONS: Body mass index was missing for 28% of patients. The primary analyses were conducted with multiple imputation for missing BMI. Upper bounding factor analysis suggested that the results are robust to possible selection bias.
+
+ CONCLUSION: Obesity is associated with increased risk for intubation or death from COVID-19 in adults younger than 65 years, but not in adults aged 65 years or older.
+
+ PRIMARY FUNDING SOURCE: National Institutes of Health.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fibrin Fibrinogen Degradation Products). 0 (Troponin). 0 (fibrin fragment D). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.7326%2fM20-3214
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Anderson&issn=0003-4819&title=Annals+of+Internal+Medicine&atitle=Body+Mass+Index+and+Risk+for+Intubation+or+Death+in+SARS-CoV-2+Infection+%3A+A+Retrospective+Cohort+Study.&volume=173&issue=10&spage=782&epage=790&date=2020&doi=10.7326%2FM20-3214&pmid=32726151&sid=OVID:medline
+
+<1238>
+Unique Identifier
+ 32725941
+Title
+ Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure.
+Source
+ Pediatric Pulmonology. 55(10):2730-2736, 2020 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ward SL; Dahmer MK; Weeks HM; Sapru A; Quasney MW; Curley MAQ; Liu KD; Matthay MA; Flori HR
+Author NameID
+ Ward, Shan L; ORCID: https://orcid.org/0000-0002-1375-6240
+ Weeks, Heidi M; ORCID: https://orcid.org/0000-0003-3467-7987
+Authors Full Name
+ Ward, Shan L; Dahmer, Mary K; Weeks, Heidi M; Sapru, Anil; Quasney, Michael W; Curley, Martha A Q; Liu, Kathleen D; Matthay, Michael A; Flori, Heidi R.
+Institution
+ Ward, Shan L. Division of Critical Care, Department of Pediatrics, UCSF Benioff Children's Hospitals, San Francisco and Oakland, California.
+ Dahmer, Mary K. Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
+ Weeks, Heidi M. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan.
+ Sapru, Anil. Division of Critical Care Medicine, Department of Pediatrics, Mattel Children's Hospital at UCLA Medical Center, Los Angeles, California.
+ Quasney, Michael W. Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
+ Curley, Martha A Q. Division of Anesthesia and Critical Care Medicine, Department of Family and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
+ Curley, Martha A Q. Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania.
+ Liu, Kathleen D. Department of Medicine, UCSF Medical Center, San Francisco, California.
+ Matthay, Michael A. Department of Anesthesia, UCSF Medical Center, San Francisco, California.
+ Matthay, Michael A. UCSF Medical Center, Cardiovascular Research Institute, San Francisco, California.
+ Flori, Heidi R. Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Body Weight
+ Child
+ Child, Preschool
+ Female
+ Humans
+ Infant
+ Male
+ *Obesity/bl [Blood]
+ *Pulmonary Surfactant-Associated Protein D/bl [Blood]
+ *Respiratory Insufficiency/bl [Blood]
+Keyword Heading
+ acute respiratory distress syndrome
+ acute respiratory failure
+ alveolar epithelial injury
+ body mass index
+ children
+ mechanical ventilation
+ obesity
+ pediatric
+ surfactant protein D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS AND OBJECTIVES: Alveolar epithelial injury is a key determinant of acute respiratory failure (ARF) severity. Plasma surfactant protein D (SP-D), a biomarker of alveolar epithelial injury, is lower in obese adults with ARF compared to their lean peers. We aimed to determine if children with ARF have similar variance in plasma SP-D associated with their weight status on admission.
+
+ METHODS: Plasma SP-D was measured on days 0, 1, or 2 in children (1-18 years) with ARF enrolled in the genetic variation and biomarkers in children with acute lung injury and RESTORE studies. Weight classification (underweight, normal, overweight, and obese) was based on body mass index or weight-for-height z-scores. Associations between weight group and SP-D on each day were tested.
+
+ RESULTS: Inclusion criteria were met in 212 subjects, 24% were obese. There were no differences among weight groups in SP-D levels on days 0 and 1. However, on day 2, there was a statistically significant linear trend for lower SP-D levels as weight increased in both the univariate analysis (P = .02) and when adjusting for age, ethnicity, and diagnosis of pediatric acute respiratory distress syndrome (P = .05).
+
+ CONCLUSIONS: Obesity was associated with lower plasma SP-D levels on day 2 of ARF. This finding may be explained by altered ARF pathogenesis in obese individuals or a reduced incidence of ventilator-induced lung injury. Copyright © 2020 Wiley Periodicals LLC.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Pulmonary Surfactant-Associated Protein D).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1002%2fppul.24990
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ward&issn=1099-0496&title=Pediatric+Pulmonology&atitle=Association+of+patient+weight+status+with+plasma+surfactant+protein+D%2C+a+biomarker+of+alveolar+epithelial+injury%2C+in+children+with+acute+respiratory+failure.&volume=55&issue=10&spage=2730&epage=2736&date=2020&doi=10.1002%2Fppul.24990&pmid=32725941&sid=OVID:medline
+
+<1239>
+Unique Identifier
+ 32718135
+Title
+ Relationship between ghrelin and obestatin levels and ghrelin/obestatin ratio in patients with asthma.
+Original Title
+ Serum ghrelin, obestatin duzeyleri ve ghrelin/obestatin oraninin astim ile iliskis.
+Source
+ Tuberkuloz ve Toraks. 68(1):9-16, 2020 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kizilirmak D; Bozkurt B; Karamanli H
+Authors Full Name
+ Kizilirmak, Deniz; Bozkurt, Bulent; Karamanli, Harun.
+Institution
+ Kizilirmak, Deniz. Department of Chest Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
+ Bozkurt, Bulent. Clinic of Allergic Diseases, Lokman Hekim Hospital, Ankara, Turkey.
+ Karamanli, Harun. Clinic of Chest Diseases, Ataturk Training and Research Hospital, Ankara, Turkey.
+MeSH Subject Headings
+ Adult
+ *Asthma/bl [Blood]
+ *Asthma/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ Female
+ *Ghrelin/bl [Blood]
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ Risk Factors
+Abstract
+ INTRODUCTION: This study aimed to evaluate serum levels of ghrelin and obestatin as well as the ghrelin/obestatin ratio in non-obese patients with asthma and in healthy non-asthmatic controls and analyzed the relationships to clinical outcomes.
+
+ MATERIALS AND METHODS: 51 patients with stable persistent asthma and 36 healthy controls were included to the study. Pulmonary function tests were conducted in all case. Skin prick test and an asthma control test were conducted in patients with asthma. All patients and controls were compared in terms of ghrelin and obestatin levels, as well as the ghrelin/obestatin ratio. Plasma concentrations of ghrelin and obestatin were detected by enzymelinked immunosorbent assay. Homeostasis model assessment-insulin resistance (HOMA-IR) scores were calculated as an index of insulin resistance.
+
+ RESULT: No differences in ghrelin or obestatin levels or the ghrelin/obestatin ratio were detected between patients with asthma and the control group. Ghrelin levels were significantly lower in obese patients. The HOMA-IR score was significantly higher in patients with asthma than in controls.
+
+ CONCLUSIONS: Ghrelin and obestatin levels, and the ghrelin/obestatin ratio, were similar in controls and patients with stable asthma. Although the groups were similar in terms of body mass index and waist circumference, the HOMA-IR score was significantly higher in patients with asthma.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ghrelin). 0 (obestatin, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.5578%2ftt.68815
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kizilirmak&issn=0494-1373&title=Tuberkuloz+ve+Toraks&atitle=Serum+ghrelin%2C+obestatin+duzeyleri+ve+ghrelin%2Fobestatin+oraninin+astim+ile+iliskis.&volume=68&issue=1&spage=9&epage=16&date=2020&doi=10.5578%2Ftt.68815&pmid=32718135&sid=OVID:medline
+
+<1240>
+Unique Identifier
+ 32710888
+Title
+ Effects of Ramadan intermittent fasting on inflammatory and biochemical biomarkers in males with obesity.
+Source
+ Physiology & Behavior. 225:113090, 2020 10 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zouhal H; Bagheri R; Ashtary-Larky D; Wong A; Triki R; Hackney AC; Laher I; Abderrahman AB
+Authors Full Name
+ Zouhal, Hassane; Bagheri, Reza; Ashtary-Larky, Damoon; Wong, Alexei; Triki, Raoua; Hackney, Anthony C; Laher, Ismail; Abderrahman, Abderraouf Ben.
+Institution
+ Zouhal, Hassane. Univ Rennes, M2S (Laboratoire Mouvement, Sport, Sante) - EA 1274, F-35000 Rennes, France. Electronic address: hassane.zouhal@univ-rennes2.fr.
+ Bagheri, Reza. Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
+ Ashtary-Larky, Damoon. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Wong, Alexei. Department of Health and Human Performance, Marymount University, Arlington, USA.
+ Triki, Raoua. ISSEP Ksar Said, University of Manouba, Tunis, Tunisia.
+ Hackney, Anthony C. Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC, USA.
+ Laher, Ismail. Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, Canada.
+ Abderrahman, Abderraouf Ben. ISSEP Ksar Said, University of Manouba, Tunis, Tunisia.
+MeSH Subject Headings
+ Biomarkers
+ C-Reactive Protein
+ *Fasting
+ Humans
+ *Islam
+ Male
+ Obesity
+Keyword Heading
+ Biochemical biomarkers
+ Fasting
+ Inflammation
+ Obese
+ Overweight
+ Ramadan
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: To determine the effects of Ramadan intermittent fasting (RIF) on inflammatory (C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha)) and biochemical markers of liver-renal function (aspartate aminotransferase (AST), alanine amino transferase (ALT), bilirubin, lactate dehydrogenase (LDH), urea and creatinine) in males with obesity.
+
+ MATERIALS AND METHODS: Twenty-eight males with obesity were randomly allocated to an experimental group (EG, n = 14) or a control group (CG, n = 14). The EG group completed their fasting rituals for the entire month of Ramadan (30 days) whereas the CG group continued with their normal daily habits. Blood samples were collected 24 h before the start of Ramadan (T0), on the 15th day of Ramadan (T1), the day after the end of Ramadan (T2), and 21 days after the end of Ramadan (T3). Resting plasma volume variation between pre and post-RIF (DELTAPV) was calculated.
+
+ RESULTS: Decreases were noted for interleukin-6 (p = 0.02, d = 1.4) and tumor necrosis factor-alpha (p = 0.01, d = 0.7), with no changes for C-reactive protein (p = 0.3; d = 0.1) in the EG compared to CG group. There were no changes (P > 0.05) in DELTAPV recorded after RIF for either EG (-0.035 +/- 0.02%) and CG (0.055 +/- 0.06%).
+
+ CONCLUSION: This study demonstrates that RIF improves systemic inflammation biomarkers in males with obesity. Moreover, RIF did not negatively affect biomarkers of liver and renal function. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.physbeh.2020.113090
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zouhal&issn=0031-9384&title=Physiology+%26+Behavior&atitle=Effects+of+Ramadan+intermittent+fasting+on+inflammatory+and+biochemical+biomarkers+in+males+with+obesity.&volume=225&issue=&spage=113090&epage=&date=2020&doi=10.1016%2Fj.physbeh.2020.113090&pmid=32710888&sid=OVID:medline
+
+<1241>
+Unique Identifier
+ 32709962
+Title
+ Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases.
+Source
+ Scientific Reports. 10(1):12415, 2020 07 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gabuza KB; Sibuyi NRS; Mobo MP; Madiehe AM
+Authors Full Name
+ Gabuza, Kwazikwakhe Bethuel; Sibuyi, Nicole Remaliah Samantha; Mobo, Mmabatho Peggy; Madiehe, Abram Madimabe.
+Institution
+ Gabuza, Kwazikwakhe Bethuel. Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa.
+ Sibuyi, Nicole Remaliah Samantha. Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa.
+ Mobo, Mmabatho Peggy. Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa.
+ Madiehe, Abram Madimabe. Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa. amadiehe@uwc.ac.za.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Blood Proteins/an [Analysis]
+ *Blood Proteins/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Gene Expression Regulation
+ Humans
+ Male
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Protein Interaction Mapping
+ Protein Interaction Maps
+ Proteomics
+ Rats
+ Risk Factors
+Abstract
+ Obesity is a chronic disease that negatively affects life expectancy through its association with life-threatening diseases such as cancer and cardiovascular diseases. Expression proteomics combined with in silico interaction studies are used to uncover potential biomarkers and the pathways that promote obesity-related complications. These biomarkers can either aid in the development of personalized therapies or identify individuals at risk of developing obesity-related diseases. To determine the serum protein changes, Wistar rats were fed standard chow (low fat, LF), or chow formulated high fat (HF) diets (HF1, HF2 and HF3) for 8 and 42 weeks to induce obesity. Serum samples were collected from lean and obese rats at these time points. The serum samples were precipitated using trichloroacetic acid (TCA)/acetone and analyzed by 2-Dimensional SDS-PAGE. Serum protein profiles were examined using mass spectrometry (MS)-based proteomics and validated by western blotting. Protein-protein interactions among the selected proteins were studied in silico using bioinformatics tools. Several proteins showed differences in expression among the three HF diets when compared to the LF diet, and only proteins with >= twofold expression levels were considered differentially expressed. Apolipoprotein-AIV (APOA4), C-reactive protein (CRP), and alpha 2-HS glycoprotein (AHSG) showed differential expression at both 8 and 42 weeks, whereas alpha 1 macroglobulin (AMBP) was differentially expressed only at 8 weeks. Network analysis revealed some interactions among the proteins, an indication that these proteins might interactively play a crucial role in development of obesity-induced diseases. These data show the variation in the expression of serum proteins during acute and chronic exposure to high fat diet. Based on the expression and the in-silico interaction these proteins warrant further investigation for their role in obesity development.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-69198-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gabuza&issn=2045-2322&title=Scientific+Reports&atitle=Differentially+expressed+serum+proteins+from+obese+Wistar+rats+as+a+risk+factor+for+obesity-induced+diseases.&volume=10&issue=1&spage=12415&epage=&date=2020&doi=10.1038%2Fs41598-020-69198-2&pmid=32709962&sid=OVID:medline
+
+<1242>
+Unique Identifier
+ 32708435
+Title
+ Baseline HOMA IR and Circulating FGF21 Levels Predict NAFLD Improvement in Patients Undergoing a Low Carbohydrate Dietary Intervention for Weight Loss: A Prospective Observational Pilot Study.
+Source
+ Nutrients. 12(7), 2020 Jul 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Watanabe M; Risi R; Camajani E; Contini S; Persichetti A; Tuccinardi D; Ernesti I; Mariani S; Lubrano C; Genco A; Spera G; Gnessi L; Basciani S
+Author NameID
+ Mariani, Stefania; ORCID: https://orcid.org/0000-0003-1762-4701
+Authors Full Name
+ Watanabe, Mikiko; Risi, Renata; Camajani, Elisabetta; Contini, Savina; Persichetti, Agnese; Tuccinardi, Dario; Ernesti, Ilaria; Mariani, Stefania; Lubrano, Carla; Genco, Alfredo; Spera, Giovanni; Gnessi, Lucio; Basciani, Sabrina.
+Institution
+ Watanabe, Mikiko. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Risi, Renata. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Camajani, Elisabetta. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Contini, Savina. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Persichetti, Agnese. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Tuccinardi, Dario. Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
+ Ernesti, Ilaria. Department of Surgical Sciences, Surgical Endoscopy Unit, Sapienza University of Rome, 00161 Rome, Italy.
+ Mariani, Stefania. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Lubrano, Carla. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Genco, Alfredo. Department of Surgical Sciences, Surgical Endoscopy Unit, Sapienza University of Rome, 00161 Rome, Italy.
+ Spera, Giovanni. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Gnessi, Lucio. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+ Basciani, Sabrina. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ *Caloric Restriction
+ *Diet, Carbohydrate-Restricted
+ *Diet, Ketogenic
+ *Fatty Acids, Omega-3/ad [Administration & Dosage]
+ Female
+ *Fibroblast Growth Factors/ad [Administration & Dosage]
+ *Fibroblast Growth Factors/bl [Blood]
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ *Non-alcoholic Fatty Liver Disease/dh [Diet Therapy]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Nutritional Physiological Phenomena/ph [Physiology]
+ Obesity/co [Complications]
+ *Obesity/dh [Diet Therapy]
+ *Obesity/me [Metabolism]
+ Observational Studies as Topic
+ Pilot Projects
+ Predictive Value of Tests
+ Prospective Studies
+ *Weight Loss
+ Young Adult
+Keyword Heading
+ fibroblast growth factor 21
+ hepatic steatosis
+ insulin resistance
+ ketogenic diet
+ non-alcoholic fatty liver disease
+ obesity
+ very low carbohydrate diet
+ very low energy diet
+ very low-calorie diet
+ very low-calorie ketogenic diet
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver disease. Very low-calorie ketogenic diets (VLCKD) represent a feasible treatment as they induce profound weight loss and insulin resistance (IR) improvement. Despite the recognized benefits on NAFLD deriving from pharmacological administration of fibroblast growth factor 21 (FGF21), whose endogenous counterpart is a marker of liver injury, little is known about its physiology in humans.
+
+ AIM: To identify predictors of NAFLD improvement as reflected by the reduction of the non-invasive screening tool hepatic steatosis index (HSI) in obese patients undergoing a weight loss program.
+
+ METHODS: Sixty-five obese patients underwent a 90-day dietary program consisting of a VLCKD followed by a hypocaloric low carbohydrate diet (LCD). Anthropometric parameters, body composition, and blood and urine chemistry were assessed.
+
+ RESULTS: Unlike most parameters improving mainly during the VLCKD, the deepest HSI change was observed after the LCD (p = 0.02 and p < 0.0001, respectively). Baseline HOMA-IR and serum FGF21 were found to be positive (R = 0.414, p = 0009) and negative (R = 0.364, p = 0.04) independent predictors of HSI reduction, respectively.
+
+ CONCLUSIONS: We suggest that patients with IR and NAFLD derive greater benefit from a VLCKD, and we propose a possible role of human FGF21 in mediating NAFLD amelioration following nutritional manipulation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Omega-3). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12072141
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Watanabe&issn=2072-6643&title=Nutrients&atitle=Baseline+HOMA+IR+and+Circulating+FGF21+Levels+Predict+NAFLD+Improvement+in+Patients+Undergoing+a+Low+Carbohydrate+Dietary+Intervention+for+Weight+Loss%3A+A+Prospective+Observational+Pilot+Study.&volume=12&issue=7&spage=&epage=&date=2020&doi=10.3390%2Fnu12072141&pmid=32708435&sid=OVID:medline
+
+<1243>
+Unique Identifier
+ 32707422
+Title
+ The up-regulation of markers of adipose tissue fibrosis by visfatin in pre-adipocytes as well as obese children and adolescents.
+Source
+ Cytokine. 134:155193, 2020 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ezzati-Mobaser S; Malekpour-Dehkordi Z; Nourbakhsh M; Tavakoli-Yaraki M; Ahmadpour F; Golpour P; Nourbakhsh M
+Authors Full Name
+ Ezzati-Mobaser, Samira; Malekpour-Dehkordi, Zahra; Nourbakhsh, Mona; Tavakoli-Yaraki, Masoumeh; Ahmadpour, Fatemeh; Golpour, Pegah; Nourbakhsh, Mitra.
+Institution
+ Ezzati-Mobaser, Samira. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
+ Malekpour-Dehkordi, Zahra. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Nourbakhsh, Mona. Hazrat Aliasghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran.
+ Tavakoli-Yaraki, Masoumeh. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
+ Ahmadpour, Fatemeh. Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Golpour, Pegah. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
+ Nourbakhsh, Mitra. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: nourbakhsh.m@iums.ac.ir.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ *Adipocytes
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Adolescent
+ Animals
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Case-Control Studies
+ Child
+ Collagen Type VI/bl [Blood]
+ Collagen Type VI/ge [Genetics]
+ Collagen Type VI/me [Metabolism]
+ Cytokines/bl [Blood]
+ *Cytokines/ph [Physiology]
+ Female
+ Fibrosis
+ Humans
+ Male
+ Matrix Metalloproteinases/bi [Biosynthesis]
+ Matrix Metalloproteinases/ge [Genetics]
+ Mice
+ Nicotinamide Phosphoribosyltransferase/bl [Blood]
+ *Nicotinamide Phosphoribosyltransferase/ph [Physiology]
+ *Obesity/bl [Blood]
+ Osteopontin/ge [Genetics]
+ Osteopontin/me [Metabolism]
+ Peptide Fragments/bl [Blood]
+ Signal Transduction
+ *Stem Cells/me [Metabolism]
+ Up-Regulation
+Keyword Heading
+ Adipose tissue fibrosis
+ Collagen
+ Endotrophin
+ Insulin resistance
+ Metabolic syndrome
+ Obesity
+ Osteopontin
+ Visfatin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipocytes are surrounded by a three-dimensional network of extracellular matrix (ECM) proteins. Aberrant ECM accumulation and remodeling leads to adipose tissue fibrosis. Visfatin is one of the adipocytokines that is increased in obesity and is implicated in insulin resistance. The objective of this study was to investigate the effect of visfatin on major components of ECM remodeling. In this study, plasma levels of both endotrophin and visfatin in obese children and adolescents were significantly higher than those in control subjects and they showed a positive correlation with each other. Treatment of 3T3-L1 pre-adipocytes with visfatin caused significant up-regulation of Osteopontin (Opn), Collagen type VI (Col6), matrix metalloproteinases MMP-2 and MMP-9. By using inhibitors of major signaling pathways it was shown that visfatin exerted its effect on Col6a3 gene expression through PI3K, JNK, and NF-kB pathways, while induced Opn gene expression via PI3K, JNK, MAPK/ERK, and NOTCH1. Our conclusion is that, the relationship between visfatin, endotrophin and insulin resistance parameters in obesity as well as increased expression of ECM proteins by visfatin suggests adipose tissue fibrosis as a mechanism for devastating effects of visfatin in obesity. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (COL6A3 protein, human). 0 (Collagen Type VI). 0 (Cytokines). 0 (Peptide Fragments). 0 (SPP1 protein, human). 0 (endotrophin). 106441-73-0 (Osteopontin). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase). EC 2-4-2-12 (nicotinamide phosphoribosyltransferase, human). EC 3-4-24 (Matrix Metalloproteinases).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.cyto.2020.155193
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ezzati-Mobaser&issn=1043-4666&title=Cytokine&atitle=The+up-regulation+of+markers+of+adipose+tissue+fibrosis+by+visfatin+in+pre-adipocytes+as+well+as+obese+children+and+adolescents.&volume=134&issue=&spage=155193&epage=&date=2020&doi=10.1016%2Fj.cyto.2020.155193&pmid=32707422&sid=OVID:medline
+
+<1244>
+Unique Identifier
+ 32707318
+Title
+ Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?. [Review]
+Source
+ Experimental Gerontology. 139:111022, 2020 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Guo A; Li K; Xiao Q
+Authors Full Name
+ Guo, Ai; Li, Kai; Xiao, Qian.
+Institution
+ Guo, Ai. Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
+ Li, Kai. Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
+ Xiao, Qian. Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address: xiaoqian1956@126.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2
+ Humans
+ Muscle, Skeletal
+ Obesity/di [Diagnosis]
+ Sarcopenia/di [Diagnosis]
+ Sarcopenia/th [Therapy]
+ *Sarcopenia
+Keyword Heading
+ Biomarker
+ Myokines
+ Sarcopenia
+ Sarcopenic obesity
+ Skeletal muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Sarcopenic obesity (SO) is a condition characterized by the occurrence of both sarcopenia and obesity and imposes a heavy burden on the health of the elderly. Controversies and challenges regarding the definition, diagnosis and treatment of SO still remain because of its complex pathogenesis and limitations. Over the past few decades, numerous studies have revealed that myokines secreted from skeletal muscle play significant roles in the regulation of muscle mass and function as well as metabolic homeostasis. Abnormalities in myokines may trigger and promote the pathogenesis underlying age-related and metabolic diseases, including obesity, sarcopenia, type 2 diabetes (T2D), and SO. This review mainly focuses on the role of myokines as potential biomarkers for the early diagnosis and therapeutic targets in SO. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.exger.2020.111022
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Guo&issn=0531-5565&title=Experimental+Gerontology&atitle=Sarcopenic+obesity%3A+Myokines+as+potential+diagnostic+biomarkers+and+therapeutic+targets%3F.&volume=139&issue=&spage=111022&epage=&date=2020&doi=10.1016%2Fj.exger.2020.111022&pmid=32707318&sid=OVID:medline
+
+<1245>
+Unique Identifier
+ 32705985
+Title
+ Adipokines in adolescence; the associations with lung function and atopy - A cross-sectional study.
+Source
+ Respiratory Medicine. 170:106063, 2020 Aug - Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mikalsen IB; Byberg K; Forman MR; Oymar K
+Authors Full Name
+ Mikalsen, Ingvild Bruun; Byberg, Kristine; Forman, Michele R; Oymar, Knut.
+Institution
+ Mikalsen, Ingvild Bruun. Department of Pediatrics, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Science, University of Bergen, Norway. Electronic address: ingvild.bruun.mikalsen@sus.no.
+ Byberg, Kristine. Department of Pediatrics, Stavanger University Hospital, Stavanger, Norway.
+ Forman, Michele R. Department of Nutritional Sciences, Purdue University, West Lafayette, IN, USA.
+ Oymar, Knut. Department of Pediatrics, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Science, University of Bergen, Norway.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ *Adiponectin/bl [Blood]
+ Adolescent
+ Age Factors
+ Asthma/di [Diagnosis]
+ *Asthma/et [Etiology]
+ Asthma/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Child
+ Cross-Sectional Studies
+ Female
+ Forced Expiratory Volume
+ Humans
+ Inflammation Mediators/bl [Blood]
+ *Leptin/bl [Blood]
+ *Lung/pp [Physiopathology]
+ Male
+ Obesity/co [Complications]
+ Risk
+ Vital Capacity
+Keyword Heading
+ Adiponectin
+ Adolescents
+ Asthma
+ Atopy
+ Leptin
+ Lung function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Both inflammatory and mechanical effects have been proposed to explain the increased risk of asthma and reduced lung function observed in obese children and adults. The evidence regarding the potential role of obesity in the aetiology of atopy and allergy is more conflicting. The adipokines leptin and adiponectin are inflammatory markers of fat metabolism which may be involved in explaining the increased risk of asthma and reduced lung function in obese children and adults. In this cross-sectional study, we aimed to study how adiponectin and leptin were associated with lung function and atopic sensitisation in adolescents. The study included 384 children at mean age 12.9 years with measurements of adiponectin, leptin, lung function and atopic sensitisation. Adiponectin and leptin levels were measured in serum, lung function was measured by spirometry and atopic sensitisation was measured by serum specific Immunoglobulin E. In linear regression models, leptin was negatively associated with forced vital capacity (FVC) (Beta: -4.13; 95% Confidence Interval: -5.83, -2.44, P < 0.001) and forced expiratory volume in the first second (FEV1) (-3.74; -5.39, -2.09, P < 0.001) after adjusting for body mass index (BMI) and other covariates. No associations were observed between adiponectin and lung function or between leptin or adiponectin and atopic sensitisation. In this cross-sectional analysis of adolescents in all weight classes, leptin was negatively associated with FEV1 and FVC independent of BMI, but no associations were found between adiponectin and lung function. The results suggest that leptin may have a functional role in the airways of healthy children. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Leptin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.rmed.2020.106063
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mikalsen&issn=0954-6111&title=Respiratory+Medicine&atitle=Adipokines+in+adolescence%3B+the+associations+with+lung+function+and+atopy+-+A+cross-sectional+study.&volume=170&issue=&spage=106063&epage=&date=2020&doi=10.1016%2Fj.rmed.2020.106063&pmid=32705985&sid=OVID:medline
+
+<1246>
+Unique Identifier
+ 32703110
+Title
+ Magnetic resonance assessment of the cerebral alterations associated with obesity development. [Review]
+Source
+ Journal of Cerebral Blood Flow & Metabolism. 40(11):2135-2151, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lizarbe B; Campillo B; Guadilla I; Lopez-Larrubia P; Cerdan S
+Author NameID
+ Lizarbe, Blanca; ORCID: https://orcid.org/0000-0002-5531-4088
+ Cerdan, Sebastian; ORCID: https://orcid.org/0000-0001-9965-0270
+Authors Full Name
+ Lizarbe, Blanca; Campillo, Basilio; Guadilla, Irene; Lopez-Larrubia, Pilar; Cerdan, Sebastian.
+Institution
+ Lizarbe, Blanca. Instituto de Investigaciones Biomedicas "Alberto Sols" CSIC/UAM, Madrid, Spain.
+ Campillo, Basilio. Instituto de Investigaciones Biomedicas "Alberto Sols" CSIC/UAM, Madrid, Spain.
+ Guadilla, Irene. Instituto de Investigaciones Biomedicas "Alberto Sols" CSIC/UAM, Madrid, Spain.
+ Lopez-Larrubia, Pilar. Instituto de Investigaciones Biomedicas "Alberto Sols" CSIC/UAM, Madrid, Spain.
+ Cerdan, Sebastian. Instituto de Investigaciones Biomedicas "Alberto Sols" CSIC/UAM, Madrid, Spain.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Cerebral Cortex/dg [Diagnostic Imaging]
+ Cerebral Cortex/pa [Pathology]
+ *Cerebral Cortex/pp [Physiopathology]
+ Diet
+ Diet, High-Fat
+ Disease Models, Animal
+ *Disease Susceptibility
+ Functional Neuroimaging/mt [Methods]
+ Humans
+ Hypothalamus/dg [Diagnostic Imaging]
+ Hypothalamus/pa [Pathology]
+ Hypothalamus/pp [Physiopathology]
+ Life Style
+ Magnetic Resonance Imaging/mt [Methods]
+ *Magnetic Resonance Imaging
+ Magnetic Resonance Spectroscopy
+ Models, Biological
+ *Obesity/et [Etiology]
+ Organ Size
+Keyword Heading
+ High-fat feeding
+ hypothalamus
+ magnetic resonance imaging
+ magnetic resonance spectroscopy
+ neuro-inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a current threat to health care systems, affecting approximately 13% of the world's adult population, and over 18% children and adolescents. The rise of obesity is fuelled by inadequate life style habits, as consumption of diets rich in fats and sugars which promote, additionally, the development of associated comorbidities. Obesity results from a neuroendocrine imbalance in the cerebral mechanisms controlling food intake and energy expenditure, including the hypothalamus and the reward and motivational centres. Specifically, high-fat diets are known to trigger an early inflammatory response in the hypothalamus that precedes weight gain, is time-dependent, and eventually extends to the remaining appetite regulating regions in the brain. Multiple magnetic resonance imaging (MRI) and spectroscopy (MRS) methods are currently available to characterize different features of cerebral obesity, including diffusion weighted, T2 and volumetric imaging and 1H and 13C spectroscopic evaluations. In particular, consistent evidences have revealed increased water diffusivity and T2 values, decreased grey matter volumes, and altered metabolic profiles and fluxes, in the brain of animal models and in obese humans. This review provides an integrative interpretation of the physio-pathological processes associated with obesity development in the brain, and the MRI and MRS methods implemented to characterize them.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1177%2f0271678X20941263
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lizarbe&issn=0271-678X&title=Journal+of+Cerebral+Blood+Flow+%26+Metabolism&atitle=Magnetic+resonance+assessment+of+the+cerebral+alterations+associated+with+obesity+development.&volume=40&issue=11&spage=2135&epage=2151&date=2020&doi=10.1177%2F0271678X20941263&pmid=32703110&sid=OVID:medline
+
+<1247>
+Unique Identifier
+ 32696178
+Title
+ Effect of weight-loss diet combined with taurine supplementation on body composition and some biochemical markers in obese women: a randomized clinical trial.
+Source
+ Amino Acids. 52(8):1115-1124, 2020 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Haidari F; Asadi M; Mohammadi-Asl J; Ahmadi-Angali K
+Author NameID
+ Asadi, Maryam; ORCID: http://orcid.org/0000-0002-2510-3722
+Authors Full Name
+ Haidari, Fatemeh; Asadi, Maryam; Mohammadi-Asl, Javad; Ahmadi-Angali, Kambiz.
+Institution
+ Haidari, Fatemeh. Department of Nutrition, Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Asadi, Maryam. Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. maryamasadi136@gmail.com.
+ Mohammadi-Asl, Javad. Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Ahmadi-Angali, Kambiz. Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adiponectin/me [Metabolism]
+ Adult
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ *Body Composition/de [Drug Effects]
+ C-Reactive Protein/an [Analysis]
+ C-Reactive Protein/me [Metabolism]
+ Cholesterol, LDL/bl [Blood]
+ Cholesterol, LDL/me [Metabolism]
+ *Diet, Reducing
+ *Dietary Supplements
+ Energy Intake
+ Female
+ Glycemic Index/de [Drug Effects]
+ Humans
+ Leptin/bl [Blood]
+ Middle Aged
+ *Obesity/dh [Diet Therapy]
+ Taurine/ad [Administration & Dosage]
+ *Taurine/pd [Pharmacology]
+ Weight Loss/de [Drug Effects]
+Keyword Heading
+ Adipokines
+ Glycaemic indices
+ Lipid profile
+ Obesity
+ Taurine
+ Weight loss diet
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Taurine (Tau), an endogenous non-protein and sulfuric-amino acid, is involved in various biological pathways including anti-inflammatory, anti-oxidation, insulin resistance inhibition, and lipid profile improvement. According to some experimental and clinical studies, insulin resistance and excess body weight are associated with reduced serum level of Tau. Therefore, this study was aimed to evaluate Tau supplementation and a diet-induced weight-loss intervention on body composition and some biochemical indices of obese women. Participants were divided randomly into the intervention (standard weight-loss group + cap Tau 3 g/day for 8 weeks, n = 20) and control (standard weight-loss group + cap placebo for 8 weeks, n = 18) groups. To achieve weight loss, all participants received an individualized diet that included a 30% reduction in their total energy intake. Chi-square test was applied to compare categorical variables between two groups at baseline. Paired t test and independent-sample t test were also used to analyze the parametric continuous data within and between the two groups, respectively. Analysis of covariance was run for controlling the confounding variables. At the post-intervention, the mean changes of total cholesterol (p = 0.03), low-density lipoprotein cholesterol (p = 0.03), leptin (p = 0. 006), total adiponectin (p = 0.04), and high sensitivity C-reactive protein (p = 0.03) decreased significantly in Tau group compared with the control group. No significant results were found in the mean changes of high-density lipoprotein cholesterol, anthropometric measurements, glycemic indices, and liver enzymes between the two groups (p > 0.05). The findings showed that Tau supplementation along with a weight-loss diet may be more effective in improving the lipid profile and metabolic risk factors compared with a weight-loss diet alone.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Cholesterol, LDL). 0 (Leptin). 1EQV5MLY3D (Taurine). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs00726-020-02876-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Haidari&issn=0939-4451&title=Amino+Acids&atitle=Effect+of+weight-loss+diet+combined+with+taurine+supplementation+on+body+composition+and+some+biochemical+markers+in+obese+women%3A+a+randomized+clinical+trial.&volume=52&issue=8&spage=1115&epage=1124&date=2020&doi=10.1007%2Fs00726-020-02876-7&pmid=32696178&sid=OVID:medline
+
+<1248>
+Unique Identifier
+ 32689809
+Title
+ Unexpected Features of Cardiac Pathology in COVID-19 Infection.
+Source
+ Circulation. 142(11):1123-1125, 2020 09 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fox SE; Li G; Akmatbekov A; Harbert JL; Lameira FS; Brown JQ; Vander Heide RS
+Authors Full Name
+ Fox, Sharon E; Li, Guang; Akmatbekov, Aibek; Harbert, Jack L; Lameira, Fernanda S; Brown, J Quincy; Vander Heide, Richard S.
+Institution
+ Fox, Sharon E. Department of Pathology, LSU Health Sciences Center, New Orleans, LA (S.E.F., A.A., J.L.H., F.S.L., R.S.V.H.). Pathology and Laboratory Medicine Service, Southeast Louisiana Veterans Healthcare System, New Orleans (S.E.F.). Department of Biomedical Engineering, Tulane University, New Orleans, LA (G.I., J.Q.B.).
+ Li, Guang. Department of Pathology, LSU Health Sciences Center, New Orleans, LA (S.E.F., A.A., J.L.H., F.S.L., R.S.V.H.). Pathology and Laboratory Medicine Service, Southeast Louisiana Veterans Healthcare System, New Orleans (S.E.F.). Department of Biomedical Engineering, Tulane University, New Orleans, LA (G.I., J.Q.B.).
+ Akmatbekov, Aibek. Department of Pathology, LSU Health Sciences Center, New Orleans, LA (S.E.F., A.A., J.L.H., F.S.L., R.S.V.H.). Pathology and Laboratory Medicine Service, Southeast Louisiana Veterans Healthcare System, New Orleans (S.E.F.). Department of Biomedical Engineering, Tulane University, New Orleans, LA (G.I., J.Q.B.).
+ Harbert, Jack L. Department of Pathology, LSU Health Sciences Center, New Orleans, LA (S.E.F., A.A., J.L.H., F.S.L., R.S.V.H.). Pathology and Laboratory Medicine Service, Southeast Louisiana Veterans Healthcare System, New Orleans (S.E.F.). Department of Biomedical Engineering, Tulane University, New Orleans, LA (G.I., J.Q.B.).
+ Lameira, Fernanda S. Department of Pathology, LSU Health Sciences Center, New Orleans, LA (S.E.F., A.A., J.L.H., F.S.L., R.S.V.H.). Pathology and Laboratory Medicine Service, Southeast Louisiana Veterans Healthcare System, New Orleans (S.E.F.). Department of Biomedical Engineering, Tulane University, New Orleans, LA (G.I., J.Q.B.).
+ Brown, J Quincy. Department of Pathology, LSU Health Sciences Center, New Orleans, LA (S.E.F., A.A., J.L.H., F.S.L., R.S.V.H.). Pathology and Laboratory Medicine Service, Southeast Louisiana Veterans Healthcare System, New Orleans (S.E.F.). Department of Biomedical Engineering, Tulane University, New Orleans, LA (G.I., J.Q.B.).
+ Vander Heide, Richard S. Department of Pathology, LSU Health Sciences Center, New Orleans, LA (S.E.F., A.A., J.L.H., F.S.L., R.S.V.H.). Pathology and Laboratory Medicine Service, Southeast Louisiana Veterans Healthcare System, New Orleans (S.E.F.). Department of Biomedical Engineering, Tulane University, New Orleans, LA (G.I., J.Q.B.).
+MeSH Subject Headings
+ Adult
+ Aged
+ Autopsy
+ *Betacoronavirus/ip [Isolation & Purification]
+ Biomarkers
+ COVID-19
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cell Death
+ Comorbidity
+ Coronavirus Infections/co [Complications]
+ Coronavirus Infections/ep [Epidemiology]
+ *Coronavirus Infections/pa [Pathology]
+ Coronavirus Infections/vi [Virology]
+ Diabetes Mellitus/ep [Epidemiology]
+ Endothelium/vi [Virology]
+ Female
+ *Heart/vi [Virology]
+ Humans
+ Lymphopenia/et [Etiology]
+ Male
+ Microscopy, Electron
+ Middle Aged
+ Muscle Cells/pa [Pathology]
+ Myocarditis/et [Etiology]
+ *Myocarditis/pa [Pathology]
+ *Myocardium/pa [Pathology]
+ Natriuretic Peptide, Brain/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Pandemics
+ Pneumonia, Viral/co [Complications]
+ Pneumonia, Viral/ep [Epidemiology]
+ *Pneumonia, Viral/pa [Pathology]
+ Pneumonia, Viral/vi [Virology]
+ Renal Insufficiency, Chronic/ep [Epidemiology]
+ SARS-CoV-2
+ Troponin I/bl [Blood]
+Keyword Heading
+ COVID-19
+ SARS virus
+ dilatation
+ heart failure
+ severe acute respiratory syndrome
+Keyword Heading Owner
+ NOTNLM
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Troponin I). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Letter.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1161%2fCIRCULATIONAHA.120.049465
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fox&issn=0009-7322&title=Circulation&atitle=Unexpected+Features+of+Cardiac+Pathology+in+COVID-19+Infection.&volume=142&issue=11&spage=1123&epage=1125&date=2020&doi=10.1161%2FCIRCULATIONAHA.120.049465&pmid=32689809&sid=OVID:medline
+
+<1249>
+Unique Identifier
+ 32688243
+Title
+ Predictive performance of traditional and novel lipid combined anthropometric indices to identify prediabetes.
+Source
+ Diabetes & Metabolic Syndrome. 14(5):1265-1272, 2020 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ramdas Nayak VK; Nayak KR; Vidyasagar S; P R
+Authors Full Name
+ Ramdas Nayak, Vineetha K; Nayak, Kirtana Raghurama; Vidyasagar, Sudha; P, Rekha.
+Institution
+ Ramdas Nayak, Vineetha K. Department of Physiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India; Department of Physiology, K S Hegde Medical Academy, Nitte Deemed to be University, Mangalore, Karnataka, 575018, India. Electronic address: drvinu1986@gmail.com.
+ Nayak, Kirtana Raghurama. Department of Physiology, Kasturba Medical College, Manipal, Manipal, 576104, India; Department of Medical Education, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India. Electronic address: kirtananayak@gmail.com.
+ Vidyasagar, Sudha. Department of Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India. Electronic address: sudha.vs@manipal.edu.
+ P, Rekha. Department of Statistics, K S Hegde Medical Academy, Nitte Deemed to be University, Mangalore, Karnataka, 575018, India. Electronic address: vishaka99r@yahoo.com.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Insulin Resistance
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Prediabetic State/di [Diagnosis]
+ Prediabetic State/me [Metabolism]
+ Prognosis
+ ROC Curve
+ Waist-Hip Ratio
+Keyword Heading
+ Lipid accumulation product
+ Prediabetes
+ Triglyceride glucose index
+ Triglyceride glucose-waist circumference
+ Visceral adiposity index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Diabetes mellitus is one of the critical public health challenges in the Indian healthcare scenario. Novel anthropometric indices are promising surrogate markers to detect prediabetes compared to the traditional anthropometric indices that only reflect gross obesity. Thus, the authors aim to analyse the potential of three novel lipid combined anthropometric indices in predicting prediabetes in the Asian Indian population.
+
+ METHODS: We conducted an age and gender-matched case-control study to identify the predictors of prediabetes. Prediabetes was diagnosed as per the American Diabetes Association (ADA) guidelines 2010. The traditional anthropometric measurements including waist circumference (WC), waist to hip ratio (WHR) and body mass index (BMI) were executed using standardised methods. Fasting lipid profile was obtained and using standardised formulas, the novel lipid combined anthropometric indices such as lipid accumulation product (LAP), visceral adiposity index (VAI) and triglyceride glucose index (TyG index) were derived. TyG related indices such as triglyceride glucose-waist circumference (TyG-WC) and triglyceride glucose-body mass index (TyG-BMI) were also calculated.
+
+ RESULTS: The novel lipid combined anthropometric indices LAP, VAI, TyG index, TyG-WC and TyG-BMI were significantly higher in subjects with prediabetes of both the genders (p < 0.05). During receiver operating characteristic (ROC) curve evaluation, TyG index (AUC = 0.802) was the superior predictive measure in males, while in females, TyG-WC (AUC = 0.767) was the best among all the markers.
+
+ CONCLUSION: TyG index and TyG-WC seem to be a superior indicator of prediabetes in the Asian Indian population in comparison with other anthropometric indices to screen prediabetes. Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.dsx.2020.06.045
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ramdas+Nayak&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Predictive+performance+of+traditional+and+novel+lipid+combined+anthropometric+indices+to+identify+prediabetes.&volume=14&issue=5&spage=1265&epage=1272&date=2020&doi=10.1016%2Fj.dsx.2020.06.045&pmid=32688243&sid=OVID:medline
+
+<1250>
+Unique Identifier
+ 32683228
+Title
+ Effects of selenium supplementation on diet-induced obesity in mice with a disruption of the selenocysteine lyase gene.
+Source
+ Journal of Trace Elements in Medicine & Biology. 62:126596, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Watanabe LM; Hashimoto AC; Torres DJ; Berry MJ; Seale LA
+Authors Full Name
+ Watanabe, Ligia M; Hashimoto, Ann C; Torres, Daniel J; Berry, Marla J; Seale, Lucia A.
+Institution
+ Watanabe, Ligia M. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, 96813, USA; Department of Internal Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo - FMRP/USP, Brazil.
+ Hashimoto, Ann C. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, 96813, USA.
+ Torres, Daniel J. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, 96813, USA.
+ Berry, Marla J. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, 96813, USA.
+ Seale, Lucia A. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, 96813, USA. Electronic address: lseale@hawaii.edu.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Energy Metabolism/de [Drug Effects]
+ Glutathione Peroxidase/me [Metabolism]
+ Lyases/ge [Genetics]
+ *Lyases/me [Metabolism]
+ Male
+ Metabolic Syndrome/ci [Chemically Induced]
+ Metabolic Syndrome/me [Metabolism]
+ Mice
+ Mice, Knockout
+ Obesity/ci [Chemically Induced]
+ *Obesity/me [Metabolism]
+ Oxidative Stress/de [Drug Effects]
+ Selenious Acid/tu [Therapeutic Use]
+ *Selenium/tu [Therapeutic Use]
+Keyword Heading
+ Diet-induced obesity
+ Selenium
+ Selenocysteine lyase
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The amino acid selenocysteine (Sec) is an integral part of selenoproteins, a class of proteins mostly involved in strong redox reactions. The enzyme Sec lyase (SCLY) decomposes Sec into selenide allowing for the recycling of the selenium (Se) atom via the selenoprotein synthesis machinery. We previously demonstrated that disruption of the Scly gene (Scly KO) in mice leads to the development of obesity and metabolic syndrome, with effects on glucose homeostasis, worsened by Se deficiency or a high-fat diet, and exacerbated in male mice. Our objective was to determine whether Se supplementation could ameliorate obesity and restore glucose homeostasis in the Scly KO mice.
+
+ METHODS: Three-weeks old male and female Scly KO mice were fed in separate experiments a diet containing 45 % kcal fat and either sodium selenite or a mixture of sodium selenite and selenomethionine (selenite/SeMet) at moderate (0.25ppm) or high (0.5-1ppm) levels for 9 weeks, and assessed for metabolic parameters, oxidative stress and expression of selenoproteins.
+
+ RESULTS: Se supplementation was unable to prevent obesity and elevated epididymal white adipose tissue weights in male Scly KO mice. Serum glutathione peroxidase activity in Scly KO mice was unchanged regardless of sex or dietary Se intake; however, supplementation with a mixture of selenite/SeMet improved oxidative stress biomarkers in the male Scly KO mice.
+
+ CONCLUSION: These results unveil sex- and selenocompound-specific regulation of energy metabolism after the loss of Scly, pointing to a role of this enzyme in the control of whole-body energy metabolism regardless of Se levels. Copyright © 2020 Elsevier GmbH. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 1-11-1-9 (Glutathione Peroxidase). EC 4 (Lyases). EC 4-4-1-16 (selenocysteine lyase). F6A27P4Q4R (Selenious Acid). H6241UJ22B (Selenium).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.jtemb.2020.126596
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Watanabe&issn=0946-672X&title=Journal+of+Trace+Elements+in+Medicine+%26+Biology&atitle=Effects+of+selenium+supplementation+on+diet-induced+obesity+in+mice+with+a+disruption+of+the+selenocysteine+lyase+gene.&volume=62&issue=&spage=126596&epage=&date=2020&doi=10.1016%2Fj.jtemb.2020.126596&pmid=32683228&sid=OVID:medline
+
+<1251>
+Unique Identifier
+ 32679761
+Title
+ Untargeted Profiling of Bile Acids and Lysophospholipids Identifies the Lipid Signature Associated with Glycemic Outcome in an Obese Non-Diabetic Clinical Cohort.
+Source
+ Biomolecules. 10(7), 2020 07 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Christinat N; Valsesia A; Masoodi M
+Author NameID
+ Masoodi, Mojgan; ORCID: https://orcid.org/0000-0001-9840-1731
+Authors Full Name
+ Christinat, Nicolas; Valsesia, Armand; Masoodi, Mojgan.
+Institution
+ Christinat, Nicolas. Nestle Research, Nestle Institute of Health Sciences, 1015 Lausanne, Switzerland.
+ Valsesia, Armand. Nestle Research, Nestle Institute of Health Sciences, 1015 Lausanne, Switzerland.
+ Masoodi, Mojgan. Nestle Research, Nestle Institute of Health Sciences, 1015 Lausanne, Switzerland.
+ Masoodi, Mojgan. Institute of Clinical Chemistry, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
+MeSH Subject Headings
+ Adult
+ *Bile Acids and Salts/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Body Weight Maintenance
+ *Caloric Restriction/mt [Methods]
+ Chromatography, Liquid
+ Cohort Studies
+ Female
+ Humans
+ Insulin Resistance
+ Lipid Metabolism
+ *Lysophospholipids/bl [Blood]
+ Male
+ Mass Spectrometry
+ Metabolomics
+ Middle Aged
+ *Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ Treatment Outcome
+Keyword Heading
+ bile acids
+ glycemic control
+ lipidomics
+ liquid chromatography
+ lysophospholipids
+ mass spectrometry
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The development of high throughput assays for assessing lipid metabolism in metabolic disorders, especially in diabetes research, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis (NASH), provides a reliable tool for identifying and characterizing potential biomarkers in human plasma for early diagnosis or prognosis of the disease and/or responses to a specific treatment. Predicting the outcome of weight loss or weight management programs is a challenging yet important aspect of such a program's success. The characterization of potential biomarkers of metabolic disorders, such as lysophospholipids and bile acids, in large human clinical cohorts could provide a useful tool for successful predictions. In this study, we validated an LC-MS method combining the targeted and untargeted detection of these lipid species. Its potential for biomarker discovery was demonstrated in a well-characterized overweight/obese cohort subjected to a low-caloric diet intervention, followed by a weight maintenance phase. Relevant markers predicting successful responses to the low-caloric diet intervention for both weight loss and glycemic control improvements were identified. The response to a controlled weight loss intervention could be best predicted using the baseline concentration of three lysophospholipids (PC(22:4/0:0), PE(17:1/0:0), and PC(22:5/0:0)). Insulin resistance on the other hand could be best predicted using clinical parameters and levels of circulating lysophospholipids and bile acids. Our approach provides a robust tool not only for research purposes, but also for clinical practice, as well as designing new clinical interventions or assessing responses to specific treatment. Considering this, it presents a step toward personalized medicine.
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers). 0 (Lysophospholipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fbiom10071049
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Christinat&issn=2218-273X&title=Biomolecules&atitle=Untargeted+Profiling+of+Bile+Acids+and+Lysophospholipids+Identifies+the+Lipid+Signature+Associated+with+Glycemic+Outcome+in+an+Obese+Non-Diabetic+Clinical+Cohort.&volume=10&issue=7&spage=&epage=&date=2020&doi=10.3390%2Fbiom10071049&pmid=32679761&sid=OVID:medline
+
+<1252>
+Unique Identifier
+ 32678995
+Title
+ Hemoglobin A1c and Early Gestational Diabetes.
+Source
+ Journal of Women's Health. 29(12):1559-1563, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Battarbee AN; Grant JH; Vladutiu CJ; Menard MK; Clark M; Manuck TA; Venkatesh KK; Boggess KA
+Authors Full Name
+ Battarbee, Ashley N; Grant, Jacqueline H; Vladutiu, Catherine J; Menard, M Kathryn; Clark, Michael; Manuck, Tracy A; Venkatesh, Kartik K; Boggess, Kim A.
+Institution
+ Battarbee, Ashley N. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+ Grant, Jacqueline H. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+ Vladutiu, Catherine J. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+ Menard, M Kathryn. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+ Clark, Michael. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+ Manuck, Tracy A. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+ Venkatesh, Kartik K. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+ Boggess, Kim A. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ *Blood Glucose/me [Metabolism]
+ Diabetes, Gestational/bl [Blood]
+ *Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/ep [Epidemiology]
+ Female
+ Glucose Tolerance Test
+ *Glycated Hemoglobin/an [Analysis]
+ Humans
+ Obesity/ep [Epidemiology]
+ Predictive Value of Tests
+ Pregnancy
+ ROC Curve
+ Retrospective Studies
+ Sensitivity and Specificity
+Keyword Heading
+ diagnosis
+ early gestational diabetes
+ hemoglobin A1c
+ pregnancy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Screening for diabetes in early pregnancy is recommended for high-risk women, however, the optimal test for the diagnosis of early gestational diabetes mellitus (GDM) is unknown. Thus, the objective of this study was to evaluate hemoglobin A1c (HbA1c) as a diagnostic test for early GDM compared with two-step testing. Materials and Methods: Retrospective cohort of women with prior GDM or obesity who had HbA1c and two-step testing <21 weeks' gestation. Early GDM was diagnosed by 1 hour, 50 g oral glucose challenge test (GCT) >=135 mg/dL and >=2 abnormal values on 3 hour, 100 g oral glucose tolerance test or GCT >200 mg/dL. The area under the receiver operating characteristic curve (AUC) evaluated HbA1c for diagnosis of early GDM. Results: Of 243 women, 14 (5.8%) had early GDM by two-step testing. Median HbA1c levels were higher among women with GDM versus those without GDM (5.8% vs. 5.3%, p < 0.001). The AUC for HbA1c compared with two-step testing was 0.80 (95% CI 0.69-0.91). The optimal HbA1c threshold was 5.6% (64% sensitivity, 84% specificity). Conclusions: HbA1c is moderately predictive of early GDM compared with two-step testing, and a threshold lower than that used for diabetes diagnosis among nonpregnant adults is justified.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1089%2fjwh.2019.8203
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Battarbee&issn=1540-9996&title=Journal+of+Women%27s+Health&atitle=Hemoglobin+A1c+and+Early+Gestational+Diabetes.&volume=29&issue=12&spage=1559&epage=1563&date=2020&doi=10.1089%2Fjwh.2019.8203&pmid=32678995&sid=OVID:medline
+
+<1253>
+Unique Identifier
+ 32666604
+Title
+ Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD.
+Source
+ FASEB Journal. 34(9):11816-11837, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Weber M; Mera P; Casas J; Salvador J; Rodriguez A; Alonso S; Sebastian D; Soler-Vazquez MC; Montironi C; Recalde S; Fucho R; Calderon-Dominguez M; Mir JF; Bartrons R; Escola-Gil JC; Sanchez-Infantes D; Zorzano A; Llorente-Cortes V; Casals N; Valenti V; Fruhbeck G; Herrero L; Serra D
+Authors Full Name
+ Weber, Mineia; Mera, Paula; Casas, Josefina; Salvador, Javier; Rodriguez, Amaia; Alonso, Sergio; Sebastian, David; Soler-Vazquez, M Carmen; Montironi, Carla; Recalde, Sandra; Fucho, Raquel; Calderon-Dominguez, Maria; Mir, Joan Francesc; Bartrons, Ramon; Escola-Gil, Joan Carles; Sanchez-Infantes, David; Zorzano, Antonio; Llorente-Cortes, Vicenta; Casals, Nuria; Valenti, Victor; Fruhbeck, Gema; Herrero, Laura; Serra, Dolors.
+Institution
+ Weber, Mineia. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Mera, Paula. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Mera, Paula. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Casas, Josefina. Research Unit on BioActive Molecules, Department of Biological Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain.
+ Casas, Josefina. Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.
+ Salvador, Javier. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Salvador, Javier. Department of Endocrinology & Nutrition, Clinica Universidad de Navarra, Pamplona, Spain.
+ Rodriguez, Amaia. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Rodriguez, Amaia. Metabolic Research Laboratory, Clinica Universidad de Navarra, IdiSNA, Pamplona, Spain.
+ Alonso, Sergio. Cancer Genetics and Epigenetics Group, Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (IGTP-PMPPC), Campus Can Ruti, Barcelona, Spain.
+ Sebastian, David. Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
+ Sebastian, David. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
+ Soler-Vazquez, M Carmen. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Montironi, Carla. Pathology Department, Hospital Clinic de Barcelona, Barcelona, Spain.
+ Montironi, Carla. Liver Cancer Translational Research Laboratory, Liver Unit, IDIBAPS-Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
+ Recalde, Sandra. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Fucho, Raquel. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Calderon-Dominguez, Maria. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Mir, Joan Francesc. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Bartrons, Ramon. Departament de Ciencies Fisiologiques, Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Spain.
+ Escola-Gil, Joan Carles. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
+ Escola-Gil, Joan Carles. IIB Sant Pau, Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain.
+ Sanchez-Infantes, David. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Sanchez-Infantes, David. Germans Trias i Pujol Research Institute (IGTP-PMPPC), Campus Can Ruti, Barcelona, Spain.
+ Zorzano, Antonio. Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Departament de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
+ Zorzano, Antonio. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
+ Llorente-Cortes, Vicenta. Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
+ Llorente-Cortes, Vicenta. CIBERCV, Institute of Health Carlos III, Madrid, Spain.
+ Llorente-Cortes, Vicenta. Cardiovascular Research Center, CSIC-ICCC, Barcelona, Spain.
+ Casals, Nuria. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Casals, Nuria. Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Valles, Spain.
+ Valenti, Victor. Metabolic Research Laboratory, Clinica Universidad de Navarra, IdiSNA, Pamplona, Spain.
+ Valenti, Victor. Department of Surgery, Clinica Universidad de Navarra, Pamplona, Spain.
+ Fruhbeck, Gema. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Fruhbeck, Gema. Metabolic Research Laboratory, Clinica Universidad de Navarra, IdiSNA, Pamplona, Spain.
+ Herrero, Laura. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Herrero, Laura. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Serra, Dolors. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
+ Serra, Dolors. Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/me [Metabolism]
+ Carnitine O-Palmitoyltransferase/ge [Genetics]
+ *Carnitine O-Palmitoyltransferase/me [Metabolism]
+ Diabetes Mellitus/et [Etiology]
+ Diabetes Mellitus/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ *Fatty Acids/me [Metabolism]
+ *Genetic Therapy/mt [Methods]
+ Humans
+ *Lipid Metabolism
+ *Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Male
+ Mice, Inbred C57BL
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ *Non-alcoholic Fatty Liver Disease/th [Therapy]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Oxidation-Reduction
+ Triglycerides/me [Metabolism]
+Keyword Heading
+ AAV
+ CPT1A
+ fatty-acid oxidation
+ gene therapy
+ hepatic steatosis
+ lipid biomarker
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high-fat diet (HFD)-induced obesity and NAFLD in mice by enhancing liver fatty acid oxidation (FAO). Moreover, we searched for potential new lipid biomarkers for monitoring liver steatosis in humans. We used adeno-associated virus (AAV) to deliver a permanently active mutant form of human carnitine palmitoyltransferase 1A (hCPT1AM), the key enzyme in FAO, in the liver of a mouse model of HFD-induced obesity and NAFLD. Expression of hCPT1AM enhanced hepatic FAO and autophagy, reduced liver steatosis, and improved glucose homeostasis. Lipidomic analysis in mice and humans before and after therapeutic interventions, such as hepatic AAV9-hCPT1AM administration and RYGB surgery, respectively, led to the identification of specific triacylglyceride (TAG) specie (C50:1) as a potential biomarker to monitor NAFFLD disease. To sum up, here we show for the first time that liver hCPT1AM gene therapy in a mouse model of established obesity, diabetes, and NAFLD can reduce HFD-induced derangements. Moreover, our study highlights TAG (C50:1) as a potential noninvasive biomarker that might be useful to monitor NAFLD in mice and humans. Copyright © 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids). 0 (Triglycerides). EC 2-3-1-21 (CPT1A protein, human). EC 2-3-1-21 (Carnitine O-Palmitoyltransferase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1096%2ffj.202000678R
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Weber&issn=0892-6638&title=FASEB+Journal&atitle=Liver+CPT1A+gene+therapy+reduces+diet-induced+hepatic+steatosis+in+mice+and+highlights+potential+lipid+biomarkers+for+human+NAFLD.&volume=34&issue=9&spage=11816&epage=11837&date=2020&doi=10.1096%2Ffj.202000678R&pmid=32666604&sid=OVID:medline
+
+<1254>
+Unique Identifier
+ 32663097
+Title
+ Nutritional and metabolic regulation of the metabolite dimethylguanidino valeric acid: an early marker of cardiometabolic disease.
+Source
+ American Journal of Physiology - Endocrinology & Metabolism. 319(3):E509-E518, 2020 09 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wali JA; Koay YC; Chami J; Wood C; Corcilius L; Payne RJ; Rodionov RN; Birkenfeld AL; Samocha-Bonet D; Simpson SJ; O'Sullivan JF
+Author NameID
+ Wali, Jibran A; ORCID: https://orcid.org/0000-0002-8524-5773
+ Birkenfeld, Andreas L; ORCID: https://orcid.org/0000-0003-1407-9023
+ Samocha-Bonet, Dorit; ORCID: https://orcid.org/0000-0001-9422-7852
+Authors Full Name
+ Wali, Jibran A; Koay, Yen Chin; Chami, Jason; Wood, Courtney; Corcilius, Leo; Payne, Richard J; Rodionov, Roman N; Birkenfeld, Andreas L; Samocha-Bonet, Dorit; Simpson, Stephen J; O'Sullivan, John F.
+Institution
+ Wali, Jibran A. Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
+ Wali, Jibran A. Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
+ Koay, Yen Chin. Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
+ Koay, Yen Chin. Faculty of Medicine and Health, School of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
+ Koay, Yen Chin. Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
+ Chami, Jason. Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
+ Chami, Jason. Faculty of Medicine and Health, School of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
+ Chami, Jason. Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
+ Wood, Courtney. Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
+ Wood, Courtney. Faculty of Medicine and Health, School of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
+ Wood, Courtney. Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
+ Corcilius, Leo. School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia.
+ Corcilius, Leo. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales, Australia.
+ Payne, Richard J. School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia.
+ Payne, Richard J. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, New South Wales, Australia.
+ Rodionov, Roman N. University Center for Vascular Medicine and Department of Medicine III-Section Angiology, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany.
+ Birkenfeld, Andreas L. Department of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tubingen, Tubingen, Germany.
+ Birkenfeld, Andreas L. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tubingen, Tubingen, Germany.
+ Birkenfeld, Andreas L. German Centre for Diabetes Research (DZD), Tubingen, Tubingen, Germany.
+ Samocha-Bonet, Dorit. The Garvan Institute of Medical Research, University of New South Wales, Sydney, New South Wales, Australia.
+ Simpson, Stephen J. Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
+ Simpson, Stephen J. Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
+ O'Sullivan, John F. Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
+ O'Sullivan, John F. Faculty of Medicine and Health, School of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
+ O'Sullivan, John F. Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
+ O'Sullivan, John F. Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
+MeSH Subject Headings
+ Adult
+ Amidohydrolases/me [Metabolism]
+ Animals
+ *Biomarkers/me [Metabolism]
+ Carbonated Beverages
+ Citrulline/me [Metabolism]
+ Diet
+ Dietary Fats/pd [Pharmacology]
+ *Guanidines/me [Metabolism]
+ *Heart Diseases/me [Metabolism]
+ Humans
+ Insulin Resistance
+ Liver/en [Enzymology]
+ Longitudinal Studies
+ Male
+ *Metabolic Diseases/me [Metabolism]
+ Mice
+ Mice, Inbred C57BL
+ Obesity/me [Metabolism]
+ Sucrose/pd [Pharmacology]
+ Transaminases/me [Metabolism]
+ *Valerates/me [Metabolism]
+Keyword Heading
+ DMGV
+ insulin resistance
+ liver
+ metabolism
+ nutrition
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Dimethylguanidino valeric acid (DMGV) is a marker of fatty liver disease, incident coronary artery disease, cardiovascular mortality, and incident diabetes. Recently, it was reported that circulating DMGV levels correlated positively with consumption of sugary beverages and negatively with intake of fruits and vegetables in three Swedish community-based cohorts. Here, we validate these results in the Framingham Heart Study Third Generation Cohort. Furthermore, in mice, diets rich in sucrose or fat significantly increased plasma DMGV concentrations. DMGV is the product of metabolism of asymmetric dimethylarginine (ADMA) by the hepatic enzyme AGXT2. ADMA can also be metabolized to citrulline by the cytoplasmic enzyme DDAH1. We report that a high-sucrose diet induced conversion of ADMA exclusively into DMGV (supporting the relationship with sugary beverage intake in humans), while a high-fat diet promoted conversion of ADMA to both DMGV and citrulline. On the contrary, replacing dietary native starch with high-fiber-resistant starch increased ADMA concentrations and induced its conversion to citrulline, without altering DMGV concentrations. In a cohort of obese nondiabetic adults, circulating DMGV concentrations increased and ADMA levels decreased in those with either liver or muscle insulin resistance. This was similar to changes in DMGV and ADMA concentrations found in mice fed a high-sucrose diet. Sucrose is a disaccharide of glucose and fructose. Compared with glucose, incubation of hepatocytes with fructose significantly increased DMGV production. Overall, we provide a comprehensive picture of the dietary determinants of DMGV levels and association with insulin resistance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fats). 0 (Guanidines). 0 (Valerates). 0 (dimethylguanidino valerate). 29VT07BGDA (Citrulline). 57-50-1 (Sucrose). EC 2-6-1 (Transaminases). EC 2-6-1-44 (Alanine-glyoxylate transaminase). EC 3-5 (Amidohydrolases). EC 3-5-3-18 (dimethylargininase).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1152%2fajpendo.00207.2020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wali&issn=0193-1849&title=American+Journal+of+Physiology+-+Endocrinology+%26+Metabolism&atitle=Nutritional+and+metabolic+regulation+of+the+metabolite+dimethylguanidino+valeric+acid%3A+an+early+marker+of+cardiometabolic+disease.&volume=319&issue=3&spage=E509&epage=E518&date=2020&doi=10.1152%2Fajpendo.00207.2020&pmid=32663097&sid=OVID:medline
+
+<1255>
+Unique Identifier
+ 32650223
+Title
+ Skin carotenoids are inversely associated with adiposity in breast cancer survivors.
+Source
+ Nutrition Research. 79:77-86, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cartmel B; Anderson C; Irwin ML; Harrigan M; Sanft T; Li F; Gellermann W; Ermakov IV; Ferrucci LM
+Authors Full Name
+ Cartmel, Brenda; Anderson, Chelsea; Irwin, Melinda L; Harrigan, Maura; Sanft, Tara; Li, Fangyong; Gellermann, Werner; Ermakov, Igor V; Ferrucci, Leah M.
+Institution
+ Cartmel, Brenda. Yale School of Public Health, 60 College St, New Haven, CT 06511; Yale Cancer Center, PO Box 208028, New Haven, CT 06519. Electronic address: brenda.cartmel@yale.edu.
+ Anderson, Chelsea. Yale School of Public Health, 60 College St, New Haven, CT 06511. Electronic address: chelsea.anderson@cancer.org.
+ Irwin, Melinda L. Yale School of Public Health, 60 College St, New Haven, CT 06511; Yale Cancer Center, PO Box 208028, New Haven, CT 06519. Electronic address: melinda.irwin@yale.edu.
+ Harrigan, Maura. Yale School of Public Health, 60 College St, New Haven, CT 06511. Electronic address: maura.harrigan@yale.edu.
+ Sanft, Tara. Yale Cancer Center, PO Box 208028, New Haven, CT 06519; Yale School of Medicine, 333 Cedar St, New Haven, CT 06511. Electronic address: tara.sanft@yale.edu.
+ Li, Fangyong. Yale School of Public Health, 60 College St, New Haven, CT 06511. Electronic address: fangyong.li@yale.edu.
+ Gellermann, Werner. Longevity Link Corporation, 391 Chipeta Way, Suite E, Salt Lake City, UT 84108. Electronic address: werner@longevitylinkcorporation.com.
+ Ermakov, Igor V. Longevity Link Corporation, 391 Chipeta Way, Suite E, Salt Lake City, UT 84108. Electronic address: igor@longevitylinkcorporation.com.
+ Ferrucci, Leah M. Yale School of Public Health, 60 College St, New Haven, CT 06511; Yale Cancer Center, PO Box 208028, New Haven, CT 06519. Electronic address: leah.ferrucci@yale.edu.
+MeSH Subject Headings
+ *Adiposity
+ Biomarkers/bl [Blood]
+ *Breast Neoplasms
+ C-Reactive Protein/an [Analysis]
+ *Cancer Survivors
+ Carotenoids/ad [Administration & Dosage]
+ *Carotenoids/an [Analysis]
+ Diet
+ Female
+ Humans
+ Leptin/bl [Blood]
+ Middle Aged
+ Obesity/pp [Physiopathology]
+ *Skin/ch [Chemistry]
+ *Weight Reduction Programs
+Keyword Heading
+ Adiposity
+ Breast cancer
+ Cancer survivors
+ Carotenoids
+ Inflammation
+ Skin
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Carotenoids are antioxidants which may mitigate some of the adverse effects of obesity, a condition associated with poor outcomes in breast cancer patients. We hypothesized that baseline skin carotenoids would be inversely associated with adiposity in breast cancer survivors and would increase with weight loss. Skin carotenoid score (SCS) was assessed by resonance Raman spectroscopy in breast cancer survivors (body mass index >=25kg/m2) enrolled in a 6-month randomized controlled weight loss trial (n=47). Measurements included total body fat using dual-energy X-ray absorptiometry, height, weight, waist and hip circumference, dietary intake, and serum biomarkers. Associations between SCS, adiposity measures, and serum biomarkers were assessed at baseline, as was the change in SCS from baseline to 6months, in the intervention and usual care groups. At baseline, SCS was inversely correlated with all adiposity measures (P<=.05). In multivariate analyses, baseline percent body fat had the strongest association with baseline SCS (partial R2=0.20). Baseline SCS was significantly inversely associated with log C-reactive protein levels (regression coefficient beta+/-SE: -0.051+/-0.019; P=.011) and log leptin (beta+/-SE: -0.019+/-0.009; P=.046), but the associations were no longer significant after adjustment for adiposity. Over the 6-month study, the intervention group had a 17.6% increase in SCS compared to a 1.5% decrease in the usual care group (P=.28). In our study of overweight and obese breast cancer survivors, dual-energy X-ray absorptiometry-measured body fat explained a large portion of the variation in skin carotenoids at baseline, suggesting a stronger association than that previously seen in studies using less accurate measures of adiposity. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). 36-88-4 (Carotenoids). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.nutres.2020.05.012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cartmel&issn=0271-5317&title=Nutrition+Research&atitle=Skin+carotenoids+are+inversely+associated+with+adiposity+in+breast+cancer+survivors.&volume=79&issue=&spage=77&epage=86&date=2020&doi=10.1016%2Fj.nutres.2020.05.012&pmid=32650223&sid=OVID:medline
+
+<1256>
+Unique Identifier
+ 32639943
+Title
+ The correct formula to calculate triglyceride-glucose index (TyG).
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 33(7):945-946, 2020 07 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alizargar J; Hsieh NC; Wu SV
+Authors Full Name
+ Alizargar, Javad; Hsieh, Nan-Chen; Wu, Shu-Fang Vivienne.
+Institution
+ Alizargar, Javad. Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.
+ Hsieh, Nan-Chen. Department of Information Management, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.
+ Wu, Shu-Fang Vivienne. College of Nursing, School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ Child
+ Glucose
+ Humans
+ *Insulin Resistance
+ Obesity
+ Overweight
+ Triglycerides
+Keyword Heading
+ biomarkers
+ insulin resistance
+ triglyceride/glucose index
+Keyword Heading Owner
+ NOTNLM
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides). IY9XDZ35W2 (Glucose).
+Publication Type
+ Letter. Comment.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1515%2fjpem-2019-0579
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alizargar&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=The+correct+formula+to+calculate+triglyceride-glucose+index+%28TyG%29.&volume=33&issue=7&spage=945&epage=946&date=2020&doi=10.1515%2Fjpem-2019-0579&pmid=32639943&sid=OVID:medline
+
+<1257>
+Unique Identifier
+ 32639442
+Title
+ Association Between a Physical Activity Vital Sign and Cardiometabolic Disease in High-Risk Patients.
+Source
+ Clinical Journal of Sport Medicine. 30(4):348-352, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nelson VR; Masocol RV; Ewing JA; Johnston S; Hale A; Wiederman M; Asif IM
+Authors Full Name
+ Nelson, Vicki R; Masocol, Robert V; Ewing, Joseph A; Johnston, Sheri; Hale, Allyson; Wiederman, Michael; Asif, Irfan M.
+Institution
+ Nelson, Vicki R. Greenville Health System, University of South Carolina School of Medicine Greenville, Greenville, SC.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Blood Pressure
+ Body Mass Index
+ *Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases/pp [Physiopathology]
+ Cardiovascular Diseases/pc [Prevention & Control]
+ Cholesterol, LDL/bl [Blood]
+ Comorbidity
+ *Exercise/ph [Physiology]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Hypertension/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Risk Factors
+ Sedentary Behavior
+ Self Report
+ Young Adult
+Abstract
+ OBJECTIVE: To determine the association between the physical activity vital sign (PAVS) and markers of cardiometabolic disease.
+
+ DESIGN: Patients were assessed through the PAVS, a validated tool self-reporting the frequency and duration of physical activity. Patients were categorized into 3 groups: inactive (0 minutes per week), underactive (1-149 minutes per week), and active (>150 minutes per week). Associations were tested between the PAVS and the cardiometabolic disease biomarkers of body mass index, hemoglobin A1c (A1c), blood pressure, and low-density lipoprotein (LDL) using one-way analyses of variance.
+
+ SETTING: High-risk family medicine residency clinic.
+
+ PARTICIPANTS: Two thousand three hundred twenty-one adult patients (age >= 18 years).
+
+ RESULTS: Participants reported a mean of 97.87 (SD = 149.35) minutes per week of exercise. Overall, 50.1% reported physical inactivity, 25.7% were underactive, and 24.3% were active. Younger individuals (P < 0.001) and men (P < 0.05) reported more physical activity than older individuals and women. Patients who reported being active were significantly less likely to be overweight (P < 0.05), obese (P < 0.05), or hypertensive (P < 0.05), but there was no association with A1c or LDL levels.
+
+ CONCLUSIONS: This is the first investigation to examine the PAVS in a high-risk population. In these patients, reported levels of physical inactivity are 150% higher than other clinical settings, and the PAVS is only associated with improvements in 2 of 4 major cardiometabolic risk factors. For this group, self-reported levels of physical activity may need to be higher for cardiovascular benefits to be realized in all 4 cardiometabolic domains. The PAVS offers health professionals an opportunity to encourage lifestyle-based interventions to reduce cardiovascular risk, but refinements may be necessary to address this population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1097%2fJSM.0000000000000588
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nelson&issn=1050-642X&title=Clinical+Journal+of+Sport+Medicine&atitle=Association+Between+a+Physical+Activity+Vital+Sign+and+Cardiometabolic+Disease+in+High-Risk+Patients.&volume=30&issue=4&spage=348&epage=352&date=2020&doi=10.1097%2FJSM.0000000000000588&pmid=32639442&sid=OVID:medline
+
+<1258>
+Unique Identifier
+ 32636120
+Title
+ The contribution of physical inactivity and socioeconomic factors to type 2 diabetes in Nepal: A structural equation modelling analysis.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(10):1758-1767, 2020 09 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Paudel S; Tran T; Owen AJ; Smith BJ
+Authors Full Name
+ Paudel, Susan; Tran, Thach; Owen, Alice J; Smith, Ben J.
+Institution
+ Paudel, Susan. School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: susan.paudelsubedi@monash.edu.
+ Tran, Thach. School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
+ Owen, Alice J. School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
+ Smith, Ben J. School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Sydney School of Public Health, The University of Sydney, Sydney, Australia.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cholesterol/bl [Blood]
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/ep [Epidemiology]
+ Educational Status
+ Employment
+ Female
+ Health Surveys
+ Humans
+ Income
+ Male
+ Middle Aged
+ *Models, Theoretical
+ Nepal/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Risk Assessment
+ Risk Factors
+ *Sedentary Behavior
+ Social Class
+ *Social Determinants of Health
+ *Socioeconomic Factors
+ Triglycerides/bl [Blood]
+ Waist Circumference
+Keyword Heading
+ Nepal
+ Physical activity
+ STEPS survey
+ Socioeconomic position
+ Structural equation modelling
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: Type 2 diabetes mellitus (T2DM) is emerging as a significant public health challenge in Nepal. Behavioural, social and economic changes are likely to play a part in the rise of this chronic disease, as they are in many developing countries. A better understanding of the relationship between physical activity (PA), socioeconomic factors and T2DM can inform the design of prevention programs. This study aimed to identify the path relationships between PA, socioeconomic position, anthropometric and metabolic variables and T2DM.
+
+ METHODS AND RESULTS: This study analysed data from 1977 Nepalese adults aged 40-69 years from the cross-sectional WHO STEPS survey undertaken in 2013. The latent variable "PA" was created using the information on domains of PA while the latent variable "socioeconomic position" was created using the variables education, occupation and ethnicity. Participants ' fasting blood glucose was used to determine their diabetes status. Structural equation modelling was conducted, and correlations and adjusted regression coefficients are reported. Individuals with higher education, in paid employment and from advantaged ethnic groups were more likely to have T2DM. Waist circumference, triglycerides and hypertension were found to have a statistically significant positive direct effect on T2DM. PA had indirect effects on T2DM, mediated by waist circumference. The indirect effects of socioeconomic position on T2DM were mediated by body mass index, waist circumference, triglycerides and total cholesterol.
+
+ CONCLUSION: Among Nepalese adults, higher socioeconomic position had a significant direct effect on T2DM, while both PA and higher socioeconomic position had significant indirect effects. Policies and programs to address T2DM in Nepal should address the factors contributing to unhealthy weight status, particularly among those of higher socioeconomic status. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.numecd.2020.06.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Paudel&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=The+contribution+of+physical+inactivity+and+socioeconomic+factors+to+type+2+diabetes+in+Nepal%3A+A+structural+equation+modelling+analysis.&volume=30&issue=10&spage=1758&epage=1767&date=2020&doi=10.1016%2Fj.numecd.2020.06.003&pmid=32636120&sid=OVID:medline
+
+<1259>
+Unique Identifier
+ 32631242
+Title
+ Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study.
+Source
+ BMC Cardiovascular Disorders. 20(1):319, 2020 07 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Goorakani Y; Sedigh Rahimabadi M; Dehghan A; Kazemi M; Chijan MR; Bijani M; Shahraki HR; Davoodi A; Farjam M; Homayounfar R
+Author NameID
+ Sedigh Rahimabadi, Massih; ORCID: https://orcid.org/0000-0002-1919-5691
+ Dehghan, Azizallah; ORCID: https://orcid.org/0000-0002-7345-0796
+ Kazemi, Maryam; ORCID: https://orcid.org/0000-0003-3467-636X
+ Chijan, Mahsa Rostami; ORCID: https://orcid.org/0000-0001-5617-9191
+ Bijani, Mostafa; ORCID: https://orcid.org/0000-0002-8067-6160
+ Shahraki, Hadi Raeisi; ORCID: https://orcid.org/0000-0003-3071-5587
+ Farjam, Mojtaba; ORCID: https://orcid.org/0000-0003-4826-2846
+ Homayounfar, Reza; ORCID: https://orcid.org/0000-0001-5398-9519
+Authors Full Name
+ Goorakani, Yashar; Sedigh Rahimabadi, Massih; Dehghan, Azizallah; Kazemi, Maryam; Chijan, Mahsa Rostami; Bijani, Mostafa; Shahraki, Hadi Raeisi; Davoodi, Ali; Farjam, Mojtaba; Homayounfar, Reza.
+Institution
+ Goorakani, Yashar. Students Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
+ Sedigh Rahimabadi, Massih. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
+ Sedigh Rahimabadi, Massih. NDepartment of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran.
+ Dehghan, Azizallah. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
+ Kazemi, Maryam. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
+ Chijan, Mahsa Rostami. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
+ Chijan, Mahsa Rostami. NDepartment of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran.
+ Bijani, Mostafa. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
+ Shahraki, Hadi Raeisi. Department of Epidemiology and Biostatistics, Faculty of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
+ Davoodi, Ali. Students Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
+ Farjam, Mojtaba. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. Farjam.md@gmail.com.
+ Homayounfar, Reza. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. r_homayounfar@yahoo.com.
+ Homayounfar, Reza. National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. r_homayounfar@yahoo.com.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Aged
+ Aged, 80 and over
+ *Anthropometry
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Heart Rate/de [Drug Effects]
+ *Heart Rate
+ Humans
+ Iran/ep [Epidemiology]
+ *Lipoproteins, LDL/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Retrospective Studies
+ Risk Factors
+ Sex Factors
+Keyword Heading
+ Alpha-blockers
+ BMI
+ Resting heart rate
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: There is a positive association between raised resting heart rate (RHR), and all causes of mortality and shorter life expectancy. Several serum biomarkers and some anthropometric factors can affect the resting heart rate. This study aimed to investigate the determinants of resting heart rate in a large random sample of the Iranian population.
+
+ MATERIAL AND METHODS: It is a standardized, retrospective study and the subjects were chosen from the baseline survey of the Prospective Epidemiological Research Study in IrAN (PERSIAN) Fasa non-communicable disease cohort study. It was conducted from winter 2014 to summer 2019 and after obtaining informed consent from a random sample, all the eligible subjects were enrolled. All anthropometric factors and biologic laboratory factors were collected and analyzed by implement smoothly clipped absolute deviation (SCAD) linear regression and SCAD quantile regression. The comparisons between males and females were done via independent T-test.
+
+ RESULTS & CONCLUSION: A total number of 9975 persons from 35 to 90 years old were included. The overall median resting heart rate was 74 (interquartile range:66-80). Mean age has no important difference between males and females (P = 0.79) but, resting heart rate was significantly higher in females (76.6 versus 71.4, P < 0.001). All anthropometric factors except wrist circumference were higher in females (P < 0.05). Age has an adverse effect on resting heart rate and also, there was a direct association between resting heart rate and systolic blood pressure and blood glucose. Alpha-blockers (coefficient = 5.2) and Beta1-blockers (coefficient = - 2.2) were the most effective drugs with positive and negative effects on resting heart rate respectively. Lower hemoglobin, obesity, and more body mass index, and more low-density lipoprotein were associated with more resting heart rate. Continuing the monitoring of this sample via our cohort study and put to action multinational prospective researches with large sample sizes and long follow-ups can lead to more precise results and better scientific judgments.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipoproteins, LDL).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12872-020-01594-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Goorakani&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Correlation+of+resting+heart+rate+with+anthropometric+factors+and+serum+biomarkers+in+a+population-based+study%3A+Fasa+PERSIAN+cohort+study.&volume=20&issue=1&spage=319&epage=&date=2020&doi=10.1186%2Fs12872-020-01594-y&pmid=32631242&sid=OVID:medline
+
+<1260>
+Unique Identifier
+ 32629899
+Title
+ Interactions among Obstructive Sleep Apnea Syndrome Severity, Sex, and Obesity on Circulatory Inflammatory Biomarkers in Patients with Suspected Obstructive Sleep Apnea Syndrome: A Retrospective, Cross-Sectional Study.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 17(13), 2020 06 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu MF; Chen YH; Chen HC; Huang WC
+Author NameID
+ Huang, Wei-Chang; ORCID: https://orcid.org/0000-0002-9733-5899
+Authors Full Name
+ Wu, Ming-Feng; Chen, Yu-Hsuan; Chen, Hui-Chen; Huang, Wei-Chang.
+Institution
+ Wu, Ming-Feng. Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.
+ Wu, Ming-Feng. Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.
+ Chen, Yu-Hsuan. Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.
+ Chen, Hui-Chen. Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.
+ Huang, Wei-Chang. Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.
+ Huang, Wei-Chang. Department of Life Sciences, National Chung-Hsing University, Taichung 402, Taiwan.
+ Huang, Wei-Chang. Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 350, Taiwan.
+ Huang, Wei-Chang. Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung 407, Taiwan.
+MeSH Subject Headings
+ Age Factors
+ Biomarkers
+ Cardiovascular Diseases/co [Complications]
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Inflammation
+ Male
+ Obesity/co [Complications]
+ *Obesity
+ Retrospective Studies
+ Risk Factors
+ Sex Factors
+ Sleep Apnea, Obstructive/co [Complications]
+ *Sleep Apnea, Obstructive
+Keyword Heading
+ CRP
+ IL-6
+ TNF-alpha
+ cardiovascular risk
+ interaction
+ obesity
+ obstructive sleep apnea syndrome severity
+ sex
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The interaction among obstructive sleep apnea syndrome (OSAS) severity, sex, and obesity on cardiovascular risk as determined by serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) remains unclear. Therefore, this study aimed to analyze individual associations between these three OSAS characteristics and three cardiovascular biomarkers and to determine whether the relationship was affected by other features in patients with suspected OSAS. For all participants (n = 100), OSAS severity and sex had an interaction effect on IL-6 level (p = 0.030). Specifically, the male patients (p = 0.005) with severe OSAS had higher IL-6 levels than those with normal to moderate OSAS, but this relationship was not significant in the female patients (p = 0.438). Moreover, in patients with normal to moderate OSAS (p = 0.004), but not in those with severe OSAS (p = 0.824), the female patients had higher IL-6 levels than the male patients. Both CRP (p = 0.001) and IL-6 (p = 0.000) levels were higher in the obese group than in the non-obese group independently of OSAS severity and sex. The three features had no effects on TNF-alpha level individually and interactively. Our findings suggest that circulatory inflammatory markers should be comprehensively evaluated in this population and that treatment and preventive therapies should be modified accordingly.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijerph17134701
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Interactions+among+Obstructive+Sleep+Apnea+Syndrome+Severity%2C+Sex%2C+and+Obesity+on+Circulatory+Inflammatory+Biomarkers+in+Patients+with+Suspected+Obstructive+Sleep+Apnea+Syndrome%3A+A+Retrospective%2C+Cross-Sectional+Study.&volume=17&issue=13&spage=&epage=&date=2020&doi=10.3390%2Fijerph17134701&pmid=32629899&sid=OVID:medline
+
+<1261>
+Unique Identifier
+ 32629236
+Title
+ Evaluation of cyclooxygenase oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry.
+Source
+ Prostaglandins Leukotrienes & Essential Fatty Acids. 160:102157, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tans R; Bande R; van Rooij A; Molloy BJ; Stienstra R; Tack CJ; Wevers RA; Wessels HJCT; Gloerich J; van Gool AJ
+Authors Full Name
+ Tans, Roel; Bande, Rieke; van Rooij, Arno; Molloy, Billy J; Stienstra, Rinke; Tack, Cees J; Wevers, Ron A; Wessels, Hans J C T; Gloerich, Jolein; van Gool, Alain J.
+Institution
+ Tans, Roel. Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
+ Bande, Rieke. Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
+ van Rooij, Arno. Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
+ Molloy, Billy J. Waters Corporation, Wilmslow, United Kingdom.
+ Stienstra, Rinke. Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
+ Tack, Cees J. Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
+ Wevers, Ron A. Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
+ Wessels, Hans J C T. Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
+ Gloerich, Jolein. Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
+ van Gool, Alain J. Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands. Electronic address: Alain.vanGool@radboudumc.nl.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Biomarkers/bl [Blood]
+ *Chromatography, High Pressure Liquid/mt [Methods]
+ Cyclooxygenase 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Humans
+ *Mass Spectrometry/mt [Methods]
+ *Obesity/me [Metabolism]
+ *Oxylipins/bl [Blood]
+ Oxylipins/ch [Chemistry]
+ Oxylipins/ip [Isolation & Purification]
+ Solid Phase Extraction
+ Workflow
+Keyword Heading
+ Assay developmentl
+ Biomarker validation
+ Mass spectrometry
+ Oxylipins
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity is associated with adipose tissue inflammation which in turn drives insulin resistance and the development of type 2 diabetes. Oxylipins are a collection of lipid metabolites, subdivided in different classes, which are involved in inflammatory cascades. They play important roles in regulating adipose tissue homeostasis and inflammation and are therefore putative biomarkers for obesity-associated adipose tissue inflammation and the subsequent risk of type 2 diabetes onset. The objective for this study is to design an assay for a specific oxylipin class and evaluate these as potential prognostic biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes.
+
+ METHODS: An optimized workflow was developed to extract oxylipins from plasma using solid-phase extraction followed by analysis using ultra-high performance liquid chromatography coupled to a triple quadrupole mass spectrometer in multiple reaction monitoring mode. This workflow was applied to clinical plasma samples obtained from obese-type 2 diabetes patients and from lean and obese control subjects.
+
+ RESULTS: The assay was analytically validated and enabled reproducible analyses of oxylipins extracted from plasma with acceptable sensitivities. Analysis of clinical samples revealed discriminative values for four oxylipins between the type 2 diabetes patients and the lean and obese control subjects, viz. PGF2alpha, PGE2, 15-keto-PGE2 and 13,14-dihydro-15-keto-PGE2. The combination of PGF2alpha and 15-keto-PGE2 had the most predictive value to discriminate type 2 diabetic patients from lean and obese controls.
+
+ CONCLUSIONS: This proof-of-principle study demonstrates the potential value of oxylipins as biomarkers to discriminate obese individuals from obese-type 2 diabetes patients. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Oxylipins). EC 1-14-99-1 (Cyclooxygenase 2).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.plefa.2020.102157
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tans&issn=0952-3278&title=Prostaglandins+Leukotrienes+%26+Essential+Fatty+Acids&atitle=Evaluation+of+cyclooxygenase+oxylipins+as+potential+biomarker+for+obesity-associated+adipose+tissue+inflammation+and+type+2+diabetes+using+targeted+multiple+reaction+monitoring+mass+spectrometry.&volume=160&issue=&spage=102157&epage=&date=2020&doi=10.1016%2Fj.plefa.2020.102157&pmid=32629236&sid=OVID:medline
+
+<1262>
+Unique Identifier
+ 32627926
+Title
+ Associations of a Panel of Adipokines with Fat Deposits and Metabolic Phenotypes in a General Population.
+Source
+ Obesity. 28(8):1550-1559, 2020 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fischer J; Volzke H; Kassubek J; Muller HP; Kuhn JP; Nauck M; Friedrich N; Zylla S
+Author NameID
+ Friedrich, Nele; ORCID: https://orcid.org/0000-0002-1017-7622
+ Zylla, Stephanie; ORCID: https://orcid.org/0000-0001-7417-4407
+Authors Full Name
+ Fischer, Julian; Volzke, Henry; Kassubek, Jan; Muller, Hans-Peter; Kuhn, Jens-Peter; Nauck, Matthias; Friedrich, Nele; Zylla, Stephanie.
+Institution
+ Fischer, Julian. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
+ Volzke, Henry. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
+ Volzke, Henry. German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany.
+ Volzke, Henry. German Center for Diabetes Research, Partner Site Greifswald, Greifswald, Germany.
+ Kassubek, Jan. Department of Neurology, University of Ulm, Ulm, Germany.
+ Muller, Hans-Peter. Department of Neurology, University of Ulm, Ulm, Germany.
+ Kuhn, Jens-Peter. Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
+ Kuhn, Jens-Peter. Institute and Policlinic of Diagnostic and Interventional Radiology, University of Dresden, Dresden, Germany.
+ Nauck, Matthias. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
+ Nauck, Matthias. German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany.
+ Friedrich, Nele. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
+ Friedrich, Nele. German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany.
+ Zylla, Stephanie. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
+ Zylla, Stephanie. German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany.
+MeSH Subject Headings
+ *Adipokines/me [Metabolism]
+ Adult
+ *Biomarkers/me [Metabolism]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Male
+ *Metabolomics/mt [Methods]
+ Middle Aged
+ *Obesity/me [Metabolism]
+ Phenotype
+ Risk Factors
+Abstract
+ OBJECTIVE: This study provides a comprehensive overview of the associations of five adipokines (adiponectin, chemerin, galectin-3, leptin, and resistin) with fat deposits, behavioral risk factors, and metabolic phenotypes.
+
+ METHODS: Using multivariable linear and logistic regression models, cross-sectional data from 4,116 participants of the population-based Study of Health in Pomerania were analyzed.
+
+ RESULTS: Participants with obesity showed higher chemerin, galectin-3, and leptin but showed lower adiponectin concentrations. Independently of other fat compounds, liver fat content, visceral adipose tissue, and subcutaneous adipose tissue (SAT) were inversely associated with adiponectin. Independent positive associations of liver fat content and SAT with chemerin as well as of SAT with galectin-3 and leptin were observed. Physically inactive participants had higher chemerin and leptin concentrations. Smokers had higher chemerin and galectin-3 as well as lower leptin. Alcohol consumption was associated with adiponectin (positive) and resistin (inverse). All adipokines were associated with at least one lipid marker. Associations with glucose metabolism were seen for adiponectin, chemerin, galectin-3, and leptin.
+
+ CONCLUSIONS: High adiponectin concentrations were related to favorable metabolic conditions, whereas high chemerin, galectin-3, and leptin were associated with an unfavorable metabolic profile. High leptin seems to be primarily indicative of obesity, whereas high adiponectin and chemerin are associated with a broader range of metabolic phenotypes. Copyright © 2020 The Authors. Obesity published by Wiley Periodicals LLC., on behalf of The Obesity Society (TOS).
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1002%2foby.22871
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fischer&issn=1930-7381&title=Obesity&atitle=Associations+of+a+Panel+of+Adipokines+with+Fat+Deposits+and+Metabolic+Phenotypes+in+a+General+Population.&volume=28&issue=8&spage=1550&epage=1559&date=2020&doi=10.1002%2Foby.22871&pmid=32627926&sid=OVID:medline
+
+<1263>
+Unique Identifier
+ 32620337
+Title
+ Soy food intake associates with changes in the metabolome and reduced blood pressure in a gut microbiota dependent manner.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(9):1500-1511, 2020 08 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shah RD; Tang ZZ; Chen G; Huang S; Ferguson JF
+Authors Full Name
+ Shah, Rachana D; Tang, Zheng-Zheng; Chen, Guanhua; Huang, Shi; Ferguson, Jane F.
+Institution
+ Shah, Rachana D. Division of Pediatric Endocrinology, Children's Hospital of Philadelphia, PA, USA.
+ Tang, Zheng-Zheng. Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Institute for Discovery, Madison, WI, USA.
+ Chen, Guanhua. Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Institute for Discovery, Madison, WI, USA.
+ Huang, Shi. Department of Biostatistics, Vanderbilt University, Nashville, TN, USA; Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University Medical Center, Nashville, TN, USA.
+ Ferguson, Jane F. Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University Medical Center, Nashville, TN, USA; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: jane.f.ferguson@vumc.org.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Pressure
+ Cross-Sectional Studies
+ *Energy Metabolism
+ Feces/ch [Chemistry]
+ Feces/mi [Microbiology]
+ Female
+ *Gastrointestinal Microbiome
+ Host-Pathogen Interactions
+ Humans
+ *Intestines/mi [Microbiology]
+ Male
+ Metabolomics
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Obesity/mi [Microbiology]
+ Obesity/pp [Physiopathology]
+ Pennsylvania
+ Ribotyping
+ *Soy Foods
+ Time Factors
+ Treatment Outcome
+ United States
+ Young Adult
+Keyword Heading
+ Blood pressure
+ Cardiometabolic health
+ Metabolome
+ Microbiome
+ Nutrition
+ Soy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Consumption of soy foods has been associated with protection against cardiometabolic disease, but the mechanisms are incompletely understood. We hypothesized that habitual soy food consumption associates with gut microbiome composition, metabolite production, and the interaction between diet, microbiota and metabolites.
+
+ METHODS AND RESULTS: We analyzed dietary soy intake, plasma and stool metabolites, and gut microbiome data from two independent cross-sectional samples of healthy US individuals (N = 75 lean or overweight, and N = 29 obese). Habitual soy intake associated with several circulating metabolites. There was a significant interaction between soy intake and gut microbiome composition, as defined by gut enterotype, on metabolites in plasma and stool. Soy consumption associated with reduced systolic blood pressure, but only in a subset of individuals defined by their gut microbiome enterotype, suggesting that responsiveness to soy may be dependent on microbiome composition. Soy intake was associated with differences in specific microbial taxa, including two taxa mapping to genus Dialister and Prevotella which appeared to be suppressed by high soy intake We identified context-dependent effects of these taxa, where presence of Prevotella was associated with higher blood pressure and a worse cardiometabolic profile, but only in the absence of Dialister.
+
+ CONCLUSIONS: The gut microbiome is an important intermediate in the interplay between dietary soy intake and systemic metabolism. Consumption of soy foods may shape the microbiome by suppressing specific taxa, and may protect against hypertension only in individuals with soy-responsive microbiota.
+
+ CLINICAL TRIALS REGISTRY: NCT02010359 at clinicaltrials.gov. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.numecd.2020.05.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shah&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Soy+food+intake+associates+with+changes+in+the+metabolome+and+reduced+blood+pressure+in+a+gut+microbiota+dependent+manner.&volume=30&issue=9&spage=1500&epage=1511&date=2020&doi=10.1016%2Fj.numecd.2020.05.001&pmid=32620337&sid=OVID:medline
+
+<1264>
+Unique Identifier
+ 32616516
+Title
+ Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation.
+Source
+ Diabetes. 69(9):1927-1935, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dedual MA; Wueest S; Challa TD; Lucchini FC; Aeppli TRJ; Borsigova M; Mauracher AA; Vavassori S; Pachlopnik Schmid J; Bluher M; Konrad D
+Author NameID
+ Bluher, Matthias; ORCID: https://orcid.org/0000-0003-0208-2065
+ Konrad, Daniel; ORCID: https://orcid.org/0000-0001-9067-4356
+Authors Full Name
+ Dedual, Mara A; Wueest, Stephan; Challa, Tenagne D; Lucchini, Fabrizio C; Aeppli, Tim R J; Borsigova, Marcela; Mauracher, Andrea A; Vavassori, Stefano; Pachlopnik Schmid, Jana; Bluher, Matthias; Konrad, Daniel.
+Institution
+ Dedual, Mara A. Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland.
+ Dedual, Mara A. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Dedual, Mara A. Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
+ Wueest, Stephan. Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland.
+ Wueest, Stephan. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Challa, Tenagne D. Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland.
+ Challa, Tenagne D. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Lucchini, Fabrizio C. Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland.
+ Lucchini, Fabrizio C. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Aeppli, Tim R J. Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland.
+ Aeppli, Tim R J. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Borsigova, Marcela. Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland.
+ Borsigova, Marcela. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Mauracher, Andrea A. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Mauracher, Andrea A. Division of Pediatric Immunology, University Children's Hospital, Zurich, Switzerland.
+ Vavassori, Stefano. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Vavassori, Stefano. Division of Pediatric Immunology, University Children's Hospital, Zurich, Switzerland.
+ Pachlopnik Schmid, Jana. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Pachlopnik Schmid, Jana. Division of Pediatric Immunology, University Children's Hospital, Zurich, Switzerland.
+ Bluher, Matthias. Department of Medicine, Endocrinology and Diabetes, University of Leipzig, Leipzig, Germany.
+ Konrad, Daniel. Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland daniel.konrad@kispi.uzh.ch.
+ Konrad, Daniel. Children's Research Center, University Children's Hospital, Zurich, Switzerland.
+ Konrad, Daniel. Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Animals
+ Biomarkers/me [Metabolism]
+ Cystatin C/bl [Blood]
+ Cystatin C/ge [Genetics]
+ *Cystatin C/me [Metabolism]
+ Cytokines/me [Metabolism]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/ge [Genetics]
+ *Inflammation/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ *Liver/me [Metabolism]
+ Male
+ Mice
+ Mice, Knockout
+ Middle Aged
+ *Muscle, Skeletal/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ Young Adult
+Abstract
+ We recently demonstrated that removal of one kidney (uninephrectomy [UniNx]) in mice reduced high-fat diet (HFD)-induced adipose tissue inflammation, thereby improving adipose tissue and hepatic insulin sensitivity. Of note, circulating cystatin C (CysC) levels were increased in UniNx compared with sham-operated mice. Importantly, CysC may have anti-inflammatory properties, and circulating CysC levels were reported to positively correlate with obesity in humans and as shown here in HFD-fed mice. However, the causal relationship of such observation remains unclear. HFD feeding of CysC-deficient (CysC knockout [KO]) mice worsened obesity-associated adipose tissue inflammation and dysfunction, as assessed by proinflammatory macrophage accumulation. In addition, mRNA expression of proinflammatory mediators was increased, whereas markers of adipocyte differentiation were decreased. Similar to findings in adipose tissue, expression of proinflammatory cytokines was increased in liver and skeletal muscle of CysC KO mice. In line, HFD-induced hepatic insulin resistance and impairment of glucose tolerance were further aggravated in KO mice. Consistently, chow-fed CysC KO mice were more susceptible to lipopolysaccharide-induced adipose tissue inflammation. In people with obesity, circulating CysC levels correlated negatively with adipose tissue Hif1alpha as well as IL6 mRNA expression. Moreover, healthy (i.e., insulin-sensitive) subjects with obesity had significantly higher mRNA expression of CysC in white adipose tissue. In conclusion, CysC is upregulated under obesity conditions and thereby counteracts inflammation of peripheral insulin-sensitive tissues and, thus, obesity-associated deterioration of glucose metabolism. Copyright © 2020 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cystatin C). 0 (Cytokines).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2337%2fdb19-1206
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dedual&issn=0012-1797&title=Diabetes&atitle=Obesity-Induced+Increase+in+Cystatin+C+Alleviates+Tissue+Inflammation.&volume=69&issue=9&spage=1927&epage=1935&date=2020&doi=10.2337%2Fdb19-1206&pmid=32616516&sid=OVID:medline
+
+<1265>
+Unique Identifier
+ 32612360
+Title
+ Association Metabolic Obesity Phenotypes with Cardiometabolic Index, Atherogenic Index of Plasma and Novel Anthropometric Indices: A Link of FTO-rs9939609 Polymorphism.
+Source
+ Vascular Health & Risk Management. 16:249-256, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abolnezhadian F; Hosseini SA; Alipour M; Zakerkish M; Cheraghian B; Ghandil P; Cheraghpour M
+Author NameID
+ Cheraghpour, Makan; ORCID: https://orcid.org/0000-0003-4459-4528
+Authors Full Name
+ Abolnezhadian, Farhad; Hosseini, Seyed Ahmad; Alipour, Meysam; Zakerkish, Mehrnoosh; Cheraghian, Bahman; Ghandil, Pegah; Cheraghpour, Makan.
+Institution
+ Abolnezhadian, Farhad. Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Hosseini, Seyed Ahmad. Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Hosseini, Seyed Ahmad. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Alipour, Meysam. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Zakerkish, Mehrnoosh. Department of Endocrinology and Metabolism, Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Cheraghian, Bahman. Department of Statistics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Ghandil, Pegah. Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Cheraghpour, Makan. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/ge [Genetics]
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ge [Genetics]
+ Cross-Sectional Studies
+ *Energy Metabolism/ge [Genetics]
+ Female
+ Gene Frequency
+ Genetic Association Studies
+ Genetic Predisposition to Disease
+ Humans
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ge [Genetics]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ge [Genetics]
+ Obesity, Metabolically Benign/bl [Blood]
+ Obesity, Metabolically Benign/di [Diagnosis]
+ *Obesity, Metabolically Benign/ge [Genetics]
+ Phenotype
+ *Polymorphism, Single Nucleotide
+ Risk Assessment
+ Risk Factors
+ Young Adult
+Keyword Heading
+ FTO
+ atherogenic index
+ cardiovascular
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The role of metabolic states in cardiovascular risks among individuals with varying degrees of obesity is unknown. The study aimed to compare cardiometabolic index (CMI), atherogenic index of plasma (AIP), lipid accumulation product (LAP) and novel anthropometric indices in metabolic and non-metabolically obese individual with regard to the role of FTO gene in Iranian adults.
+
+ METHODS: In total, 165 individuals were recruited into this cross-sectional study. Individuals grouped into four groups: metabolic healthy normal-weight (MHNW) individuals, metabolically unhealthy normal-weight (MUNW) individuals, metabolically healthy obese (MHO) individuals and metabolic unhealthy obese (MUO) individuals. The dietary intake was evaluated by food frequency questionnaire (FFQ). The cardiovascular indices (CMI, AIP and LAP) were calculated. A variety of anthropometric indices were calculated, including body adiposity Index (BAI), weight-adjusted-waist index (WWI), A body shape index (ABSI) and waist-height ratio (WHR). The genotypes of FTO-rs9939609 subjects were detected by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
+
+ RESULTS: The individuals with metabolically unhealthy phenotypes (MUO, MUNW) have higher levels of triglyceride and cardiovascular indices (AIP, LAP and CMI) than the individuals with metabolic healthy phenotypes (MHO, MHNW). With a similar degree of obesity, the anthropometric indices (BAI, WWI and WHR) levels were higher in metabolic unhealthy groups than metabolically healthy groups. The highest frequency of obesity-risk allele AA of FTO gene was observed in MUO, MHO, MUNW and MHNW, respectively.
+
+ CONCLUSION: Normal-weight individuals with metabolic unhealthy status are at higher risk for cardiovascular diseases than obese individuals with metabolically healthy status. The genotype frequencies of obesity-risk allele AA of FTO gene were higher in obesity phenotypes than metabolic phenotypes. Copyright © 2020 Abolnezhadian et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). EC 1-14-11-33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO). EC 1-14-11-33 (FTO protein, human).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2147%2fVHRM.S251927
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abolnezhadian&issn=1176-6344&title=Vascular+Health+%26+Risk+Management&atitle=Association+Metabolic+Obesity+Phenotypes+with+Cardiometabolic+Index%2C+Atherogenic+Index+of+Plasma+and+Novel+Anthropometric+Indices%3A+A+Link+of+FTO-rs9939609+Polymorphism.&volume=16&issue=&spage=249&epage=256&date=2020&doi=10.2147%2FVHRM.S251927&pmid=32612360&sid=OVID:medline
+
+<1266>
+Unique Identifier
+ 32612355
+Title
+ Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men.
+Source
+ Clinical Interventions In Aging. 15:953-967, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kemmler W; von Stengel S; Kohl M; Rohleder N; Bertsch T; Sieber CC; Freiberger E; Kob R
+Author NameID
+ Kemmler, Wolfgang; ORCID: https://orcid.org/0000-0003-3515-0669
+ Kohl, Matthias; ORCID: https://orcid.org/0000-0001-9514-8910
+ Rohleder, Nicolas; ORCID: https://orcid.org/0000-0003-2602-517X
+ Kob, Robert; ORCID: https://orcid.org/0000-0002-0406-092X
+Authors Full Name
+ Kemmler, Wolfgang; von Stengel, Simon; Kohl, Matthias; Rohleder, Nicolas; Bertsch, Thomas; Sieber, Cornel C; Freiberger, Ellen; Kob, Robert.
+Institution
+ Kemmler, Wolfgang. Institute of Medical Physics, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany.
+ von Stengel, Simon. Institute of Medical Physics, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany.
+ Kohl, Matthias. Faculty of Medical and Life Science, University of Furtwangen, Schwenningen, Germany.
+ Rohleder, Nicolas. Institute of Psychology, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany.
+ Bertsch, Thomas. Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, General Hospital Nuremberg, Paracelsus Medical University, Nuremberg, Germany.
+ Sieber, Cornel C. Institute for Biomedicine of Aging, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Nuremberg, Germany.
+ Freiberger, Ellen. Institute for Biomedicine of Aging, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Nuremberg, Germany.
+ Kob, Robert. Institute for Biomedicine of Aging, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Nuremberg, Germany.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers
+ *Diet, High-Protein/mt [Methods]
+ Dietary Supplements
+ *Electric Stimulation Therapy/mt [Methods]
+ Humans
+ Male
+ Muscle, Skeletal/pp [Physiopathology]
+ Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Sarcopenia/co [Complications]
+ Sarcopenia/pp [Physiopathology]
+ *Sarcopenia/th [Therapy]
+Keyword Heading
+ CK-MB
+ cystatin C
+ electromyostimulation
+ high protein
+ hsTnT
+ rhabdomyolysis
+ sarcopenic obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Whole-body electromyostimulation (WB-EMS) especially in combination with a high-protein supplementation has been established as an efficient treatment against sarcopenia. However, there are several case reports of rhabdomyolysis after WB-EMS application. Thus, we asked if this training could potentially lead to deteriorations of the cardiac as well as the renal function.
+
+ MATERIALS AND METHODS: One hundred sarcopenic obese men aged 70 years and older were randomly balanced (1-1-1) and allocated to one of the three study arms. During 16 weeks of intervention, these groups either performed WB-EMS and took a protein supplement (WB-EMS&P), solely received the protein supplement (Protein) or served as control group (CG). WB-EMS consisted of 1.5x20 min (85 Hz, 350 mus, 4 s of strain to 4 s of rest) applied with moderate-to-high intensity while moving. We further generated a daily protein intake of 1.7-1.8 g/kg/body mass per day. At baseline and 8-10 days after completion of the intervention, blood was drawn and biomarkers of muscle, cardiac and renal health were assessed.
+
+ RESULTS: Hereby, we found slight but significant elevations of creatine kinase (CK) levels in the WB-EMS group pointing to minor damages of the skeletal muscle (140 U/l [81-210], p < 0.001). This was accompanied by a significant, low-grade increase of creatine kinase-muscle brain (CK-MB, 0.43 ng/mL [-0.29-0.96], p < 0.01) and high-sensitivity troponin T (hsTnT, 0.001 ng/mL. [0.000-0.003], p < 0.001) but without a higher risk of developing heart failure according to N-terminal prohormone of brain natriuretic peptide (NT-proBNP, -5.7 pg/mL [-38.8-24.6], p = 0.17). Estimated glomerular filtration rate (eGFR) was impaired neither by the high-protein supplementation alone nor in combination with WB-EMS (CG 76.0 mL/min/1.73 m2 [71.9-82.2] vs Protein 73.2 mL/min/1.73 m2 [63.0-78.9] vs WB-EMS&P 74.6 mL/min/1.73 m2 [62.8-84.1], p = 0.478).
+
+ CONCLUSION: In conclusion, even in the vulnerable group of sarcopenic obese seniors, the combination of WB-EMS with a high-protein intake revealed no short-term, negative impact on the eGFR, but potential consequences for the cardiovascular system need to be addressed in future studies. Copyright © 2020 Kemmler et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2147%2fCIA.S248868
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kemmler&issn=1176-9092&title=Clinical+Interventions+In+Aging&atitle=Safety+of+a+Combined+WB-EMS+and+High-Protein+Diet+Intervention+in+Sarcopenic+Obese+Elderly+Men.&volume=15&issue=&spage=953&epage=967&date=2020&doi=10.2147%2FCIA.S248868&pmid=32612355&sid=OVID:medline
+
+<1267>
+Unique Identifier
+ 32610503
+Title
+ Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies. [Review]
+Source
+ Nutrients. 12(7), 2020 Jun 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Boachie J; Adaikalakoteswari A; Samavat J; Saravanan P
+Author NameID
+ Boachie, Joseph; ORCID: https://orcid.org/0000-0003-3950-6423
+ Adaikalakoteswari, Antonysunil; ORCID: https://orcid.org/0000-0003-2974-3388
+ Saravanan, Ponnusamy; ORCID: https://orcid.org/0000-0002-9566-2626
+Authors Full Name
+ Boachie, Joseph; Adaikalakoteswari, Antonysunil; Samavat, Jinous; Saravanan, Ponnusamy.
+Institution
+ Boachie, Joseph. Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV2 2 DX, UK.
+ Adaikalakoteswari, Antonysunil. Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV2 2 DX, UK.
+ Adaikalakoteswari, Antonysunil. Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8 NS, UK.
+ Samavat, Jinous. Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV2 2 DX, UK.
+ Saravanan, Ponnusamy. Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV2 2 DX, UK.
+ Saravanan, Ponnusamy. Diabetes Centre, George Eliot Hospital NHS Trust, College Street, Nuneaton, CV10 7 DJ, UK.
+MeSH Subject Headings
+ Adult
+ Animals
+ Biomarkers/me [Metabolism]
+ Cardiometabolic Risk Factors
+ Child
+ DNA Methylation/de [Drug Effects]
+ *Epigenesis, Genetic/de [Drug Effects]
+ Female
+ Histones/de [Drug Effects]
+ Humans
+ *Lipid Metabolism/de [Drug Effects]
+ Male
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/me [Metabolism]
+ MicroRNAs/de [Drug Effects]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Pregnancy
+ *Vitamin B 12/me [Metabolism]
+ Vitamin B 12 Deficiency/et [Etiology]
+ *Vitamin B 12 Deficiency/me [Metabolism]
+Keyword Heading
+ cardiovascular disease (CVD)
+ lipid metabolism
+ metabolic syndrome (MetS)
+ obesity
+ type 2 diabetes mellitus (T2D)
+ vitamin B12 (B12)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a worldwide epidemic responsible for 5% of global mortality. The risks of developing other key metabolic disorders like diabetes, hypertension and cardiovascular diseases (CVDs) are increased by obesity, causing a great public health concern. A series of epidemiological studies and animal models have demonstrated a relationship between the importance of vitamin B12 (B12) and various components of metabolic syndrome. High prevalence of low B12 levels has been shown in European (27%) and South Indian (32%) patients with type 2 diabetes (T2D). A longitudinal prospective study in pregnant women has shown that low B12 status could independently predict the development of T2D five years after delivery. Likewise, children born to mothers with low B12 levels may have excess fat accumulation which in turn can result in higher insulin resistance and risk of T2D and/or CVD in adulthood. However, the independent role of B12 on lipid metabolism, a key risk factor for cardiometabolic disorders, has not been explored to a larger extent. In this review, we provide evidence from pre-clinical and clinical studies on the role of low B12 status on lipid metabolism and insights on the possible epigenetic mechanisms including DNA methylation, micro-RNA and histone modifications. Although, there are only a few association studies of B12 on epigenetic mechanisms, novel approaches to understand the functional changes caused by these epigenetic markers are warranted.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Histones). 0 (MicroRNAs). P6YC3EG204 (Vitamin B 12).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12071925
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Boachie&issn=2072-6643&title=Nutrients&atitle=Low+Vitamin+B12+and+Lipid+Metabolism%3A+Evidence+from+Pre-Clinical+and+Clinical+Studies.&volume=12&issue=7&spage=&epage=&date=2020&doi=10.3390%2Fnu12071925&pmid=32610503&sid=OVID:medline
+
+<1268>
+Unique Identifier
+ 32606431
+Title
+ Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes.
+Source
+ Scientific Reports. 10(1):10635, 2020 06 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khadir A; Kavalakatt S; Madhu D; Devarajan S; Abubaker J; Al-Mulla F; Tiss A
+Author NameID
+ Tiss, Ali; ORCID: http://orcid.org/0000-0002-3024-5370
+Authors Full Name
+ Khadir, Abdelkrim; Kavalakatt, Sina; Madhu, Dhanya; Devarajan, Sriraman; Abubaker, Jehad; Al-Mulla, Fahd; Tiss, Ali.
+Institution
+ Khadir, Abdelkrim. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, P.O. Box1180, 15462, Dasman, Kuwait.
+ Kavalakatt, Sina. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, P.O. Box1180, 15462, Dasman, Kuwait.
+ Madhu, Dhanya. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, P.O. Box1180, 15462, Dasman, Kuwait.
+ Devarajan, Sriraman. Research Division, Dasman Diabetes Institute, Dasman, Kuwait.
+ Abubaker, Jehad. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, P.O. Box1180, 15462, Dasman, Kuwait.
+ Al-Mulla, Fahd. Research Division, Dasman Diabetes Institute, Dasman, Kuwait.
+ Tiss, Ali. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, P.O. Box1180, 15462, Dasman, Kuwait. ali.tiss@dasmaninstitute.org.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/th [Therapy]
+ *Exercise Therapy/mt [Methods]
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/th [Therapy]
+ Oxygen Consumption
+ *Peptide Hormones/bl [Blood]
+Abstract
+ Spexin is a novel neuropeptide playing an emerging role in metabolic diseases such as obesity and diabetes via involvement in energy homeostasis and food intake. The present study investigated the effects of obesity and type 2 diabetes (T2D) on circulating levels of spexin and its modulation by physical exercise. Normal-weight (n = 50) and obese adults with and without T2D (n = 69 and n = 66, respectively) were enrolled in the study. A subgroup of obese participants (n = 47) underwent a supervised 3-month exercise programme. Plasma spexin levels were measured by ELISA and correlated with various markers. Plasma spexin levels decreased in obese participants with or without T2D compared with those of normal-weight participants (0.43 +/- 0.11, 0.44 +/- 0.12 and 0.61 +/- 0.23 ng/ml, respectively; P < 0.001). Spexin levels negatively correlated with adiposity markers and blood pressure in the whole study population (P < 0.05). Multiple regression analysis revealed blood pressure was the greatest predictive determinant of plasma spexin levels, which significantly increased in response to physical exercise in obese participants without and with T2D (P < 0.05). Spexin levels significantly increased only in responders to exercise (those with increased oxygen consumption, VO2 max) with a concomitant improvement in metabolic profile. In conclusion, plasma spexin levels may be an indicator of response to physical exercise.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Hormones). 0 (SPX protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-67624-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khadir&issn=2045-2322&title=Scientific+Reports&atitle=Spexin+as+an+indicator+of+beneficial+effects+of+exercise+in+human+obesity+and+diabetes.&volume=10&issue=1&spage=10635&epage=&date=2020&doi=10.1038%2Fs41598-020-67624-z&pmid=32606431&sid=OVID:medline
+
+<1269>
+Unique Identifier
+ 32605884
+Title
+ Management of metabolic alterations in adult kidney transplant recipients: A joint position statement of the Italian Society of Nephrology (SIN), the Italian Society for Organ Transplantation (SITO) and the Italian Diabetes Society (SID).
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(9):1427-1441, 2020 08 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Conte C; Maggiore U; Cappelli G; Ietto G; Lai Q; Salis P; Marchetti P; Piemonti L; Secchi A; Capocasale E; Caldara R
+Authors Full Name
+ Conte, Caterina; Maggiore, Umberto; Cappelli, Gianni; Ietto, Giuseppe; Lai, Quirino; Salis, Paola; Marchetti, Piero; Piemonti, Lorenzo; Secchi, Antonio; Capocasale, Enzo; Caldara, Rossana.
+Institution
+ Conte, Caterina. Universita Vita-Salute San Raffaele, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy. Electronic address: conte.caterina@hsr.it.
+ Maggiore, Umberto. Dipartimento di Medicina e Chirurgia, University Hospital of Parma, Parma, Italy. Electronic address: umberto.maggiore@unipr.it.
+ Cappelli, Gianni. University of Modena and Reggio Emilia, Azienda Ospedaliero - Universitaria Policlinico, Modena, Italy. Electronic address: gianni.cappelli@unimore.it.
+ Ietto, Giuseppe. Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy. Electronic address: giuseppe.ietto@gmail.com.
+ Lai, Quirino. Hepato-Biliary Surgery and Organ Transplantation Unit, Sapienza University of Rome, Umberto I Polyclinic of Rome, Rome, Italy. Electronic address: quirino.lai@uniroma1.it.
+ Salis, Paola. IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy. Electronic address: psalis@ISMETT.edu.
+ Marchetti, Piero. University of Pisa, Pisa, Italy. Electronic address: piero.marchetti@med.unipi.it.
+ Piemonti, Lorenzo. Universita Vita-Salute San Raffaele, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: piemonti.lorenzo@hsr.it.
+ Secchi, Antonio. Universita Vita-Salute San Raffaele, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy. Electronic address: secchi.antonio@hsr.it.
+ Capocasale, Enzo. Parma University Hospital, Parma, Italy. Electronic address: ecapocasale15@gmail.com.
+ Caldara, Rossana. IRCCS San Raffaele Hospital, Milan, Italy. Electronic address: caldara.rossana@hsr.it.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ Clinical Decision-Making
+ Consensus
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus/th [Therapy]
+ Drug Substitution
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/ep [Epidemiology]
+ *Dyslipidemias/th [Therapy]
+ *Energy Metabolism/de [Drug Effects]
+ Evidence-Based Medicine
+ Humans
+ Hypoglycemic Agents/ae [Adverse Effects]
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ Hypolipidemic Agents/ae [Adverse Effects]
+ *Hypolipidemic Agents/tu [Therapeutic Use]
+ Immunosuppressive Agents/ad [Administration & Dosage]
+ *Immunosuppressive Agents/ae [Adverse Effects]
+ *Kidney Transplantation/ae [Adverse Effects]
+ Lipids/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity/th [Therapy]
+ Patient Selection
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ *Risk Reduction Behavior
+Keyword Heading
+ Dyslipidaemia
+ Kidney transplant
+ Obesity
+ Overweight
+ Post-transplant diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Chronic metabolic alterations such as post-transplant diabetes mellitus (PTDM), dyslipidaemias and overweight/obesity significantly impact on kidney transplant (KT) outcomes. This joint position statement is based on the evidence on the management of metabolic alterations in KT recipients (KTRs) published after the release of the 2009 KDIGO clinical practice guideline for the care of KTRs. Members of the Italian Society of Nephrology (SIN), the Italian Society for Organ Transplantation (SITO) and the Italian Diabetes Society (SID) selected to represent professionals involved in the management of KTRs undertook a systematic review of the published evidence for the management of PTDM, dyslipidaemias and obesity in this setting. The aim of this work is to provide an updated review of the evidence on the prevention, diagnosis and treatment of metabolic alterations in KTRs, in order to support physicians, patients and the Healthcare System in the decision-making process when choosing among the various available options. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hypoglycemic Agents). 0 (Hypolipidemic Agents). 0 (Immunosuppressive Agents). 0 (Lipids).
+Publication Type
+ Journal Article. Practice Guideline. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.numecd.2020.05.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Conte&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Management+of+metabolic+alterations+in+adult+kidney+transplant+recipients%3A+A+joint+position+statement+of+the+Italian+Society+of+Nephrology+%28SIN%29%2C+the+Italian+Society+for+Organ+Transplantation+%28SITO%29+and+the+Italian+Diabetes+Society+%28SID%29.&volume=30&issue=9&spage=1427&epage=1441&date=2020&doi=10.1016%2Fj.numecd.2020.05.004&pmid=32605884&sid=OVID:medline
+
+<1270>
+Unique Identifier
+ 32598787
+Title
+ [Systemic inflammation in patients with chronic obstructive pulmonary disease and obesity]. [Russian]
+Source
+ Terapevticheskii Arkhiv. 92(3):13-18, 2020 Apr 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ovsyannikov ES; Avdeev SN; Budnevsky AV
+Author NameID
+ Ovsyannikov, E S; ORCID: https://orcid.org/0000-0002-8545-6255
+Authors Full Name
+ Ovsyannikov, E S; Avdeev, S N; Budnevsky, A V.
+Institution
+ Ovsyannikov, E S. Burdenko Voronezh State Medical University.
+ Avdeev, S N. Sechenov First Moscow State Medical University (Sechenov University).
+ Budnevsky, A V. Burdenko Voronezh State Medical University.
+MeSH Subject Headings
+ Biomarkers
+ C-Reactive Protein/an [Analysis]
+ Female
+ Humans
+ Inflammation
+ Interleukin-6
+ Male
+ Obesity
+ *Pulmonary Disease, Chronic Obstructive
+ Tumor Necrosis Factor-alpha
+Keyword Heading
+ adipokines
+ chronic obstructive pulmonary disease
+ interleukins
+ obesity
+ systemic inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Chronic obstructive pulmonary disease (COPD) is an important public health problem. According to various studies, the prevalence of obesity in patients with COPD is as high as 50%.
+
+ AIM: To evaluate pro- and anti-inflammatory cytokine profile, lung diseases biomarkers levels and adipokines levels in patients with COPD and obesity.
+
+ MATERIALS AND METHODS: The study included 88 patients with COPD (GOLD 24, group D). Patients were divided into two groups. The first group consisted of 44 patients with COPD and normal body weight: 35 men and 9 women. The second group 44 patients with obesity and COPD: 34 men and 10 women. The levels of pro- and anti-inflammatory cytokines were determined interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor (TNF-), interleukin-4 (IL-4), interleukin-10 (IL-10), as well as the concentration of highly sensitive C-reactive protein (CRP), surfactant protein D, elastase, leptin, adiponectin, 1-antitrypsin, receptors of tumor necrosis factor 1 and 2 (TNF-R1, TNF-R2).
+
+ RESULTS: In patients with COPD and obesity, compared with patients with COPD and normal body weight, the levels of CRP, interferon-, TNF-, TNF-R1, TNF-R2 were significantly higher. At the same time, the levels of IL-4, IL-6, IL-8, IL-10 did not differ significantly. The level of leptin in patients with COPD and obesity was significantly higher than in patients with COPD and normal body weight.
+
+ CONCLUSION: In patients with COPD and obesity, in contrast to patients with COPD with normal body weight, the severity of systemic inflammation is significantly higher. However, further research is needed in this area.
+Other Abstract
+ Publisher
+ XpoH ecka o cTpykT BHa o e3Hb e k x (XOB ) B eTc Ba Ho po eMo 3 paBooxpaHeH . So acHo aHHblM pa3Hblx cc e oBaH , pac pocTpaHeHHocTb o peH y o bHblx XOB ocT aeT 50%. e b. O eH Tb oco eHHocT po- poT BoBoc a Te bHo o Tok HoBo o po , ypoBH oMapkepoB e o Ho aTo o a ok HoB y o bHblx XOB o peH eM. MaTep a bl MeTo bl. B cc e oBaH e Bk eHbl 88 o bHblx XOB (GOLD 24, py a D). a eHTbl pac pe e eHbl B 2 py bl. epBa py a cocTaB a 44 o bHblx XOB c HopMa bHo Macco Te a: 35 My H 9 eH H. BTopa py a 44 o bHblx XOB o peH eM: 34 My Hbl 10 eH H. O pe e ypoBH oka3aTe e po- poT BoBoc a Te bHo o Tok HoBo o po HTep e k Ha ( )-6, -8, akTopa Hekpo3a o yxo e ( HO-), -4, -10, a Tak e koH eHTpa Bblcoko yBcTB Te bHo o S-peakT BHo o e ka, cyp akTaHTHo o e ka D, acTa3bl, e T Ha, a oHekT Ha, 1-aHT Tp c Ha, pe e TopoB HO 1 2 ( HO-R1, HO-R2). Pe3y bTaTbl. Y o bHblx XOB o peH eM o cpaBHeH c o bHblM XOB c HopMa bHo Macco Te a ocToBepHo Bbl e bl ypoBH S-peakT BHo o e ka, HTep epoHa-, HO-, HO-R1, HO-R2. p ToM 3Ha eH -4, -6, -8, -10 y o bHblx B cc e yeMblx py ax ocToBepHo He pa3 a cb. YpoBeHb e T Ha y o bHblx XOB o peH eM o cpaBHeH c o bHblM XOB c HopMa bHo Macco Te a bl ocToBepHo Bbl e. ak eH e. Y o bHblx XOB o peH eM B oT e oT o bHblx XOB c HopMa bHo Macco Te a Bblpa eHHocTb c cTeMHo o Boc a eH ocToBepHo Bbl e. O Hako Tpe y Tc a bHe e cc e oBaH B To o acT .
+ Language: Russian
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.26442%2f00403660.2020.03.000265
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ovsyannikov&issn=0040-3660&title=Terapevticheskii+Arkhiv&atitle=%5BSystemic+inflammation+in+patients+with+chronic+obstructive+pulmonary+disease+and+obesity%5D.&volume=92&issue=3&spage=13&epage=18&date=2020&doi=10.26442%2F00403660.2020.03.000265&pmid=32598787&sid=OVID:medline
+
+<1271>
+Unique Identifier
+ 32598403
+Title
+ Which salivary components can differentiate metabolic obesity?.
+Source
+ PLoS ONE [Electronic Resource]. 15(6):e0235358, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ostrowska L; Gornowicz A; Pietraszewska B; Bielawski K; Bielawska A
+Author NameID
+ Gornowicz, Agnieszka; ORCID: https://orcid.org/0000-0002-0945-7870
+ Pietraszewska, Barbara; ORCID: https://orcid.org/0000-0002-5033-7168
+ Bielawska, Anna; ORCID: https://orcid.org/0000-0001-9164-8440
+Authors Full Name
+ Ostrowska, Lucyna; Gornowicz, Agnieszka; Pietraszewska, Barbara; Bielawski, Krzysztof; Bielawska, Anna.
+Institution
+ Ostrowska, Lucyna. Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Bialystok, Poland.
+ Gornowicz, Agnieszka. Department of Biotechnology, Medical University of Bialystok, Bialystok, Poland.
+ Pietraszewska, Barbara. Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Bialystok, Poland.
+ Bielawski, Krzysztof. Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Bialystok, Poland.
+ Bielawska, Anna. Department of Biotechnology, Medical University of Bialystok, Bialystok, Poland.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/me [Metabolism]
+ *Body Mass Index
+ Case-Control Studies
+ *Cytokines/me [Metabolism]
+ Female
+ Humans
+ Middle Aged
+ *Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Pilot Projects
+ *Saliva/ch [Chemistry]
+ *Salivary Proteins and Peptides/me [Metabolism]
+Abstract
+ BACKGROUND: Obesity is a multifactorial disease and represents a global and relevant health problem. The aim of the study was to assess the concentration of pro-inflammatory cytokines (tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8)) and other selected proteins as well as enzymes (soluble intercellular adhesion molecule 1 (sICAM1), calprotectin, matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2), toll like receptor 2 (TLR2)) detectable in the saliva of women who varied in body composition. It was debated whether there are marker factors in saliva that could indicate metabolic obesity.
+
+ METHODS AND FINDINGS: The pilot study included 10 women with obesity (BMI>30 kg/m2) and 6 women with normal body weight (control group). The levels of TNF-alpha, IL-8, sICAM1, calprotectin, MMP-9, MMP-2, and TLR2 were checked by using the ELISA technique. We proved that women with metabolic obesity had significantly increased concentrations of IL-8, calprotectin, and MMP-2 in comparison with healthy subjects. Significant positive correlations of BMI with TNF-alpha, IL-8, and MMP-2 were observed. Similarly, the content of fat (in kg and %) in the bodies of the women correlated positively with TNF-alpha, IL-8, and MMP-2. Whereas, the visceral adipose tissue (VAT) correlated positively only with TNF-alpha and MMP-2, similarly to VAT/SAT. The WHR (waist hip ratio) was also positively correlated with TNF-alpha and MMP-2. Interestingly, we found that the level of insulin positively correlated with TNF- alpha concentration, which additionally confirmed metabolic obesity.
+
+ CONCLUSIONS: We found that positive correlations of body mass index were observed only with salivary concentrations of TNF-alpha, MMP-2, and IL-8. Thus, it is worth conducting a study among a larger number of people taking into account these three salivary components.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Salivary Proteins and Peptides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0235358
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ostrowska&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Which+salivary+components+can+differentiate+metabolic+obesity%3F.&volume=15&issue=6&spage=e0235358&epage=&date=2020&doi=10.1371%2Fjournal.pone.0235358&pmid=32598403&sid=OVID:medline
+
+<1272>
+Unique Identifier
+ 32594915
+Title
+ Consumption of whole purple and regular wheat modestly improves metabolic markers in adults with elevated high-sensitivity C-reactive protein: a randomised, single-blind parallel-arm study.
+Source
+ British Journal of Nutrition. 124(11):1179-1189, 2020 12 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gamel TH; Abdel-Aal EM; Tucker AJ; Pare SM; Faughnan K; O'Brien CD; Dykun A; Rabalski I; Pickard M; Wright AJ
+Authors Full Name
+ Gamel, Tamer H; Abdel-Aal, El-Sayed M; Tucker, Amy J; Pare, Shannon M; Faughnan, Kate; O'Brien, Charlene D; Dykun, Andrea; Rabalski, Iwona; Pickard, Mark; Wright, Amanda J.
+Institution
+ Gamel, Tamer H. Department of Human Health & Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, OntarioN1G 2W1, Canada.
+ Gamel, Tamer H. Guelph Research & Development Centre, Agriculture and Agri-Food Canada, Guelph, OntarioN1G 5C9, Canada.
+ Abdel-Aal, El-Sayed M. Guelph Research & Development Centre, Agriculture and Agri-Food Canada, Guelph, OntarioN1G 5C9, Canada.
+ Tucker, Amy J. Department of Human Health & Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, OntarioN1G 2W1, Canada.
+ Pare, Shannon M. Department of Human Health & Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, OntarioN1G 2W1, Canada.
+ Faughnan, Kate. Department of Human Health & Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, OntarioN1G 2W1, Canada.
+ O'Brien, Charlene D. Department of Human Health & Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, OntarioN1G 2W1, Canada.
+ Dykun, Andrea. Department of Human Health & Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, OntarioN1G 2W1, Canada.
+ Rabalski, Iwona. Guelph Research & Development Centre, Agriculture and Agri-Food Canada, Guelph, OntarioN1G 5C9, Canada.
+ Pickard, Mark. Infra-Ready Products Ltd, Saskatoon, SaskatchewanS7M 5T2, Canada.
+ Wright, Amanda J. Department of Human Health & Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, OntarioN1G 2W1, Canada.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ *C-Reactive Protein/me [Metabolism]
+ Cardiometabolic Risk Factors
+ Diet/mt [Methods]
+ *Eating/ph [Physiology]
+ Female
+ Humans
+ Inflammation
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Overweight/bl [Blood]
+ Oxidative Stress/ph [Physiology]
+ Single-Blind Method
+ *Triticum
+ *Whole Grains
+ Young Adult
+Keyword Heading
+ Anthocyanins
+ Inflammation
+ Overweight and obesity
+ Oxidative stress
+ Phenolic acids
+ Whole wheat and bran
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Whole-grain wheat, in particular coloured varieties, may have health benefits in adults with chronic metabolic disease risk factors. Twenty-nine overweight and obese adults with chronic inflammation (high-sensitivity C-reactive protein) > 1.0 mg/l) replaced four daily servings of refined grain food products with bran-enriched purple or regular whole-wheat convenience bars (approximately 41-45 g fibre, daily) for 8 weeks in a randomised, single-blind parallel-arm study where body weight was maintained. Anthropometrics, blood markers of inflammation, oxidative stress, and lipaemia and metabolites of anthocyanins and phenolic acids were compared at days 1, 29 and 57 using repeated-measures ANOVA within groups and ANCOVA between groups at day 57, with day 1 as a covariate. A significant reduction in IL-6 and increase in adiponectin were observed within the purple wheat (PW) group. TNF-alpha was lowered in both groups and ferulic acid concentration increased in the regular wheat (RW) group. Comparing between wheats, only plasma TNF-alpha and glucose differed significantly (P < 0.05), that is, TNF-alpha and glucose decreased with RW and PW, respectively. Consumption of PW or RW products showed potential to improve plasma markers of inflammation and oxidative stress in participants with evidence of chronic inflammation, with modest differences observed based on type of wheat.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1017%2fS0007114520002275
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gamel&issn=0007-1145&title=British+Journal+of+Nutrition&atitle=Consumption+of+whole+purple+and+regular+wheat+modestly+improves+metabolic+markers+in+adults+with+elevated+high-sensitivity+C-reactive+protein%3A+a+randomised%2C+single-blind+parallel-arm+study.&volume=124&issue=11&spage=1179&epage=1189&date=2020&doi=10.1017%2FS0007114520002275&pmid=32594915&sid=OVID:medline
+
+<1273>
+Unique Identifier
+ 32594318
+Title
+ Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention. [Review]
+Source
+ Current Obesity Reports. 9(3):219-230, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aleksandrova K; Egea Rodrigues C; Floegel A; Ahrens W
+Authors Full Name
+ Aleksandrova, Krasimira; Egea Rodrigues, Caue; Floegel, Anna; Ahrens, Wolfgang.
+Institution
+ Aleksandrova, Krasimira. Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany. krasimira.aleksandrova@dife.de.
+ Aleksandrova, Krasimira. Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. krasimira.aleksandrova@dife.de.
+ Egea Rodrigues, Caue. Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
+ Egea Rodrigues, Caue. Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
+ Floegel, Anna. Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
+ Ahrens, Wolfgang. Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
+ Ahrens, Wolfgang. Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ *Genomics/mt [Methods]
+ Humans
+ *Metabolomics/mt [Methods]
+ Obesity/et [Etiology]
+ *Obesity/pc [Prevention & Control]
+ *Precision Medicine/mt [Methods]
+ *Preventive Medicine/mt [Methods]
+ Proteomics/mt [Methods]
+ Reproducibility of Results
+Keyword Heading
+ Biomarkers
+ Genomics
+ Metabolomics
+ Obesity
+ Proteomics
+ Transcriptomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE OF REVIEW: Omics-based technologies were suggested to provide an advanced understanding of obesity etiology and its metabolic consequences. This review highlights the recent developments in "omics"-based research aimed to identify obesity-related biomarkers.
+
+ RECENT FINDINGS: Recent advances in obesity and metabolism research increasingly rely on new technologies to identify mechanisms in the development of obesity using various "omics" platforms. Genetic and epigenetic biomarkers that translate into changes in transcriptome, proteome, and metabolome could serve as targets for obesity prevention. Despite a number of promising candidate biomarkers, there is an increased demand for larger prospective cohort studies to validate findings and determine biomarker reproducibility before they can find applications in primary care and public health. "Omics" biomarkers have advanced our knowledge on the etiology of obesity and its links with chronic diseases. They bring substantial promise in identifying effective public health strategies that pave the way towards patient stratification and precision prevention.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs13679-020-00393-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aleksandrova&issn=2162-4968&title=Current+Obesity+Reports&atitle=Omics+Biomarkers+in+Obesity%3A+Novel+Etiological+Insights+and+Targets+for+Precision+Prevention.&volume=9&issue=3&spage=219&epage=230&date=2020&doi=10.1007%2Fs13679-020-00393-y&pmid=32594318&sid=OVID:medline
+
+<1274>
+Unique Identifier
+ 32590977
+Title
+ A structural equation model to assess the pathways of body adiposity and inflammation status on dysmetabolic biomarkers via red cell distribution width and mean corpuscular volume: a cross-sectional study in overweight and obese subjects.
+Source
+ Lipids in Health & Disease. 19(1):154, 2020 Jun 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rondanelli M; Perna S; Alalwan TA; Cazzola R; Gasparri C; Infantino V; Perdoni F; Iannello G; Pepe D; Guido D
+Author NameID
+ Gasparri, Clara; ORCID: http://orcid.org/0000-0002-1088-6648
+Authors Full Name
+ Rondanelli, Mariangela; Perna, Simone; Alalwan, Tariq A; Cazzola, Roberta; Gasparri, Clara; Infantino, Vittoria; Perdoni, Federica; Iannello, Giancarlo; Pepe, Daniele; Guido, Davide.
+Institution
+ Rondanelli, Mariangela. IRCCS Mondino Foundation, 27100, Pavia, Italy.
+ Rondanelli, Mariangela. Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100, Pavia, Italy.
+ Perna, Simone. Department of Biology, College of Science, University of Bahrain, Sakhir Campus, P. O. Box 32038, Zallaq, Kingdom of Bahrain.
+ Alalwan, Tariq A. Department of Biology, College of Science, University of Bahrain, Sakhir Campus, P. O. Box 32038, Zallaq, Kingdom of Bahrain.
+ Cazzola, Roberta. Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, Milan, Italy.
+ Gasparri, Clara. Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100, Pavia, Italy. clara.gasparri01@universitadipavia.it.
+ Infantino, Vittoria. Department of Biomedical Science and Human Oncology, University of Bari, 70121, Bari, Italy.
+ Perdoni, Federica. Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona "Istituto Santa Margherita", University of Pavia, 27100, Pavia, Italy.
+ Iannello, Giancarlo. General Management, Azienda di Servizi alla Persona "Istituto Santa Margherita", 27100, Pavia, Italy.
+ Pepe, Daniele. Hasselt University, I-BioStat, Diepenbeek, Belgium.
+ Guido, Davide. Neurology, Public Health, Disability Unit, Scientific Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
+ Guido, Davide. Epidemiology Unit, Agency for Health Protection of Milan, Milan, Italy.
+MeSH Subject Headings
+ *Adiposity/ph [Physiology]
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ Cross-Sectional Studies
+ *Erythrocyte Indices/ph [Physiology]
+ Female
+ Humans
+ Inflammation
+ Lipids/bl [Blood]
+ *Lipids
+ Male
+ Middle Aged
+ *Models, Biological
+ Obesity/me [Metabolism]
+ *Overweight/me [Metabolism]
+ Overweight/pp [Physiopathology]
+ Oxidative Stress/ph [Physiology]
+ Waist Circumference
+ Young Adult
+Keyword Heading
+ Inflammation
+ Mean corpuscular volume
+ Metabolism
+ Obesity
+ Path analysis
+ Pathway
+ Reactive oxygen species
+ Red cell distribution width
+ Structural equation modelling
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: A study has been performed in overweight and obese subjects to assess the effects of adiposity and inflammation indicators on dysmetabolic biomarkers via red cell distribution width (RDW) and mean corpuscular volume (MCV), taking into account pro-antioxidant balance.
+
+ METHODS: Data from 166 overweight subjects were analyzed by a path analysis model using structural equation modelling (SEM) to evaluate the direct and indirect pathway effects of adiposity, measured by body mass index (BMI) and waist circumference (WC), and inflammation status, measured by pro-antioxidant balance [reactive oxygen species (ROS)], lag-time and slope and C-reactive protein (CRP) values on dysmetabolic biomarkers, via RDW and MCV.
+
+ RESULTS: BMI was strongly linked to CRP and ROS levels. Moreover, there was a significant negative decrease of MCV (1.546 femtoliters) linked to BMI indirectly via high CRP levels. Furthermore, WC affected RDW, indicating a possible mediatory role for RDW in relation to the relationship between WC and homeostatic model assessment (HOMA), insulin and high density lipoprotein (HDL), respectively. This was evident by the elevated HOMA and insulin levels and the decreased levels of HDL. Finally, ROS-related markers did not affect directly RDW and MCV.
+
+ CONCLUSION: The reported outcomes suggest that RDW might play a mediatory role in the relationship between WC and the dysmetabolic outcomes in overweight and obese individuals. CRP seems to modulate the linkage between BMI and MCV. This study provides the backbone structure for future scenarios and lays the foundation for further research on the role of RDW and MCV as suitable biomarkers for the assessment of cardiovascular disease (HDL-cholesterol), inflammatory bowels and insulin resistance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12944-020-01308-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rondanelli&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=A+structural+equation+model+to+assess+the+pathways+of+body+adiposity+and+inflammation+status+on+dysmetabolic+biomarkers+via+red+cell+distribution+width+and+mean+corpuscular+volume%3A+a+cross-sectional+study+in+overweight+and+obese+subjects.&volume=19&issue=1&spage=154&epage=&date=2020&doi=10.1186%2Fs12944-020-01308-5&pmid=32590977&sid=OVID:medline
+
+<1275>
+Unique Identifier
+ 32589682
+Title
+ Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes.
+Source
+ PLoS ONE [Electronic Resource]. 15(6):e0234970, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Concepcion J; Chen K; Saito R; Gangoiti J; Mendez E; Nikita ME; Barshop BA; Natarajan L; Sharma K; Kim JJ
+Author NameID
+ Barshop, Bruce A; ORCID: https://orcid.org/0000-0001-9264-3270
+ Kim, Jane J; ORCID: https://orcid.org/0000-0002-0228-0128
+Authors Full Name
+ Concepcion, Jennifer; Chen, Katherine; Saito, Rintaro; Gangoiti, Jon; Mendez, Eric; Nikita, Maria Eleni; Barshop, Bruce A; Natarajan, Loki; Sharma, Kumar; Kim, Jane J.
+Institution
+ Concepcion, Jennifer. Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America.
+ Concepcion, Jennifer. Rady Children's Hospital, San Diego, CA, United States of America.
+ Chen, Katherine. Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America.
+ Saito, Rintaro. Keio University, Yamagata, Japan.
+ Gangoiti, Jon. Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America.
+ Mendez, Eric. Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America.
+ Nikita, Maria Eleni. Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America.
+ Barshop, Bruce A. Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America.
+ Barshop, Bruce A. Rady Children's Hospital, San Diego, CA, United States of America.
+ Natarajan, Loki. Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, United States of America.
+ Sharma, Kumar. Center for Renal Precision Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, Unied States of America.
+ Kim, Jane J. Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America.
+ Kim, Jane J. Rady Children's Hospital, San Diego, CA, United States of America.
+MeSH Subject Headings
+ Adolescent
+ Amino Acids, Branched-Chain/me [Metabolism]
+ Betaine/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Biomarkers/ur [Urine]
+ Biosynthetic Pathways
+ Chromatography, High Pressure Liquid
+ Computational Biology
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/ur [Urine]
+ Female
+ Humans
+ *Insulin Resistance
+ Male
+ Metabolomics/mt [Methods]
+ Nucleic Acids/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ Obesity/ur [Urine]
+ *Purines/bi [Biosynthesis]
+ Tandem Mass Spectrometry
+ Young Adult
+Abstract
+ The incidence of type 2 diabetes is increasing more rapidly in adolescents than in any other age group. We identified and compared metabolite signatures in obese children with type 2 diabetes (T2D), obese children without diabetes (OB), and healthy, age- and gender-matched normal weight controls (NW) by measuring 273 analytes in fasting plasma and 24-hour urine samples from 90 subjects by targeted LC-MS/MS. Diabetic subjects were within 2 years of diagnosis in an attempt to capture early-stage disease prior to declining renal function. We found 22 urine metabolites that were uniquely associated with T2D when compared to OB and NW groups. The metabolites most significantly elevated in T2D youth included members of the betaine pathway, nucleic acid metabolism, and branched-chain amino acids (BCAAs) and their catabolites. Notably, the metabolite pattern in OB and T2D groups differed between urine and plasma, suggesting that urinary BCAAs and their intermediates behaved as a more specific biomarker for T2D, while plasma BCAAs associated with the obese, insulin resistant state independent of diabetes status. Correlative analysis of metabolites in the T2D signature indicated that betaine metabolites, BCAAs, and aromatic amino acids were associated with hyperglycemia, but BCAA acylglycine derivatives and nucleic acid metabolites were linked to insulin resistance. Of major interest, we found that urine levels of succinylaminoimidazole carboxamide riboside (SAICA-riboside) were increased in diabetic youth, identifying urine SAICA-riboside as a potential biomarker for T2D.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers). 0 (Nucleic Acids). 0 (Purines). 3SCV180C9W (Betaine).
+Publication Type
+ Journal Article. Observational Study. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1371%2fjournal.pone.0234970
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Concepcion&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Identification+of+pathognomonic+purine+synthesis+biomarkers+by+metabolomic+profiling+of+adolescents+with+obesity+and+type+2+diabetes.&volume=15&issue=6&spage=e0234970&epage=&date=2020&doi=10.1371%2Fjournal.pone.0234970&pmid=32589682&sid=OVID:medline
+
+<1276>
+Unique Identifier
+ 32587472
+Title
+ IL-17A in the Psoriatic Patients' Serum and Plaque Scales as Potential Marker of the Diseases Severity and Obesity.
+Source
+ Mediators of Inflammation. 2020:7420823, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Michalak-Stoma A; Bartosinska J; Kowal M; Raczkiewicz D; Krasowska D; Chodorowska G
+Author NameID
+ Michalak-Stoma, Anna; ORCID: https://orcid.org/0000-0002-4599-6249
+ Bartosinska, Joanna; ORCID: https://orcid.org/0000-0003-4106-3051
+ Kowal, Malgorzata; ORCID: https://orcid.org/0000-0003-3333-9660
+ Raczkiewicz, Dorota; ORCID: https://orcid.org/0000-0003-3517-6711
+ Krasowska, Dorota; ORCID: https://orcid.org/0000-0002-3176-9870
+ Chodorowska, Grazyna; ORCID: https://orcid.org/0000-0002-8055-5764
+Authors Full Name
+ Michalak-Stoma, Anna; Bartosinska, Joanna; Kowal, Malgorzata; Raczkiewicz, Dorota; Krasowska, Dorota; Chodorowska, Grazyna.
+Institution
+ Michalak-Stoma, Anna. Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
+ Bartosinska, Joanna. Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
+ Kowal, Malgorzata. Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
+ Raczkiewicz, Dorota. Institute of Statistics and Demography, Warsaw School of Economics, al. Niepodleglosci 162, 02-554 Warsaw, Poland.
+ Krasowska, Dorota. Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
+ Chodorowska, Grazyna. Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/bl [Blood]
+ Humans
+ *Interleukin-17/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ *Psoriasis/bl [Blood]
+ *Psoriasis/pa [Pathology]
+ Quality of Life
+ Severity of Illness Index
+Abstract
+ The aim of the study was to evaluate concentrations of IL-17 in the serum and plaque scales of psoriatic patients. We analyzed their association with the clinical activity of the disease and with body mass index (BMI). Demographic data, medical history, serum, and scale from psoriatic plaques for assessment of IL-17 were collected from all the participants. The disease severity was assessed with PASI (Psoriasis Area and Severity Index), BSA (Body Surface Area), PGA (Physician Global Assessment), NAPSI (Nail Psoriasis Severity Index), and DLQI (Dermatology Quality of Life Index) scores. Obesity was diagnosed by calculating body mass index. Serum and scale concentration of IL-17 was determined with Human IL-17A High Sensitivity ELISA kit and Human IL-17 ELISA kit. In the psoriatic patients, BMI was statistically significantly higher than in the control group. Most of the patients presented BMI higher than normal. Our study confirms that overweight is a problem among psoriatic patients. A significant positive correlation between the IL-17 serum and scale concentrations and psoriasis severity indicates that IL-17 can be used as the marker of disease severity. More data from human studies can be crucial for understanding that relationship between IL-17, psoriasis, and obesity. Copyright © 2020 Anna Michalak-Stoma et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IL17A protein, human). 0 (Interleukin-17).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1155%2f2020%2f7420823
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Michalak-Stoma&issn=0962-9351&title=Mediators+of+Inflammation&atitle=IL-17A+in+the+Psoriatic+Patients%27+Serum+and+Plaque+Scales+as+Potential+Marker+of+the+Diseases+Severity+and+Obesity.&volume=2020&issue=&spage=7420823&epage=&date=2020&doi=10.1155%2F2020%2F7420823&pmid=32587472&sid=OVID:medline
+
+<1277>
+Unique Identifier
+ 32586980
+Title
+ 3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism.
+Source
+ Diabetes. 69(9):1903-1916, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nilsen MS; Jersin RA; Ulvik A; Madsen A; McCann A; Svensson PA; Svensson MK; Nedrebo BG; Gudbrandsen OA; Tell GS; Kahn CR; Ueland PM; Mellgren G; Dankel SN
+Author NameID
+ McCann, Adrian; ORCID: https://orcid.org/0000-0002-5728-5321
+ Kahn, C R; ORCID: https://orcid.org/0000-0002-7583-9228
+ Dankel, Simon N; ORCID: https://orcid.org/0000-0001-6972-1824
+Authors Full Name
+ Nilsen, Mona S; Jersin, Regine A; Ulvik, Arve; Madsen, Andre; McCann, Adrian; Svensson, Per-Arne; Svensson, Maria K; Nedrebo, Bjorn G; Gudbrandsen, Oddrun A; Tell, Grethe S; Kahn, C R; Ueland, Per M; Mellgren, Gunnar; Dankel, Simon N.
+Institution
+ Nilsen, Mona S. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
+ Nilsen, Mona S. Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
+ Jersin, Regine A. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
+ Jersin, Regine A. Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
+ Ulvik, Arve. Bevital AS, Bergen, Norway.
+ Madsen, Andre. Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
+ Madsen, Andre. Department of Clinical Science, University of Bergen, Bergen, Norway.
+ McCann, Adrian. Bevital AS, Bergen, Norway.
+ Svensson, Per-Arne. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Svensson, Per-Arne. Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Svensson, Maria K. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
+ Nedrebo, Bjorn G. Department of Clinical Science, University of Bergen, Bergen, Norway.
+ Nedrebo, Bjorn G. Department of Medicine, Haugesund Hospital, Haugesund, Norway.
+ Gudbrandsen, Oddrun A. Department of Clinical Medicine, University of Bergen, Bergen, Norway.
+ Tell, Grethe S. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
+ Kahn, C R. Joslin Diabetes Center, Harvard Medical School, Boston, MA.
+ Ueland, Per M. Bevital AS, Bergen, Norway.
+ Mellgren, Gunnar. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
+ Mellgren, Gunnar. Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
+ Dankel, Simon N. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway simon.dankel@uib.no.
+ Dankel, Simon N. Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
+MeSH Subject Headings
+ *Adipocytes, Brown/me [Metabolism]
+ *Adipocytes, White/me [Metabolism]
+ Amino Acids, Branched-Chain/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Body Composition/ph [Physiology]
+ Cell Differentiation
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Humans
+ *Hydroxybutyrates/bl [Blood]
+ *Insulin Resistance/ph [Physiology]
+ Male
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+Abstract
+ Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and established type 2 diabetes. In complementary cohorts with measures of insulin resistance, we found positive correlates for circulating 3-HIB concentrations with HOMA2 of insulin resistance, as well as a transient increase in 3-HIB followed by a marked decrease after bariatric surgery and weight loss. During differentiation, both white and brown adipocytes upregulate BCAA utilization and release increasing amounts of 3-HIB. Knockdown of the 3-HIB-forming enzyme 3-hydroxyisobutyryl-CoA hydrolase decreases release of 3-HIB and lipid accumulation in both cell types. Conversely, addition of 3-HIB to white and brown adipocyte cultures increases fatty acid uptake and modulated insulin-stimulated glucose uptake in a time-dependent manner. Finally, 3-HIB treatment decreases mitochondrial oxygen consumption and generation of reactive oxygen species in white adipocytes, while increasing these measures in brown adipocytes. Our data establish 3-HIB as a novel adipocyte-derived regulator of adipocyte subtype-specific functions strongly linked to obesity, insulin resistance, and type 2 diabetes. Copyright © 2020 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers). 0 (Hydroxybutyrates). K75C8JDF5W (3-hydroxyisobutyric acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2337%2fdb19-1174
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nilsen&issn=0012-1797&title=Diabetes&atitle=3-Hydroxyisobutyrate%2C+A+Strong+Marker+of+Insulin+Resistance+in+Type+2+Diabetes+and+Obesity+That+Modulates+White+and+Brown+Adipocyte+Metabolism.&volume=69&issue=9&spage=1903&epage=1916&date=2020&doi=10.2337%2Fdb19-1174&pmid=32586980&sid=OVID:medline
+
+<1278>
+Unique Identifier
+ 32584326
+Title
+ CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF PATIENTS DIAGNOSED WITH COVID-19 IN A TERTIARY CARE CENTER IN MEXICO CITY: A PROSPECTIVE COHORT STUDY.
+Source
+ Revista de Investigacion Clinica. 72(3):165-177, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ortiz-Brizuela E; Villanueva-Reza M; Gonzalez-Lara MF; Tamez-Torres KM; Roman-Montes CM; Diaz-Mejia BA; Perez-Garcia E; Olivas-Martinez A; Rajme-Lopez S; Martinez-Guerra BA; de-Leon-Cividanes NA; Fernandez-Garcia OA; Guerrero-Torres L; Torres-Gonzalez L; Carrera-Patino FA; Corral-Herrera EA; Hernandez-Alemon AN; Tovar-Vargas MLA; Serrano-Pinto YG; Espejo-Ortiz CE; Morales-Ortega ML; Lozano-Cruz OA; Cardenas-Fragoso JL; Vidal-Mayo JJ; Hernandez-Gilsoul T; Rivero-Sigarroa E; Dominguez-Cherit G; Cervantes-Villar LE; Ramos-Cervantes MDP; Ibarra-Gonzalez V; Calva-Mercado JJ; Sierra-Madero JG; Lopez-Iniguez A; Ochoa-Hein E; Crabtree-Ramirez BE; Galindo-Fraga A; Guerrero-Almeida ML; Ruiz-Palacios GM; Gulias-Herrero A; Sifuentes-Osornio J; Kershenobich-Stalnikowitz D; Ponce-de-Leon A
+Authors Full Name
+ Ortiz-Brizuela, Edgar; Villanueva-Reza, Marco; Gonzalez-Lara, Maria F; Tamez-Torres, Karla M; Roman-Montes, Carla M; Diaz-Mejia, Bruno A; Perez-Garcia, Esteban; Olivas-Martinez, Antonio; Rajme-Lopez, Sandra; Martinez-Guerra, Bernardo A; de-Leon-Cividanes, Nereyda A; Fernandez-Garcia, Oscar A; Guerrero-Torres, Lorena; Torres-Gonzalez, Lorena; Carrera-Patino, Fabian A; Corral-Herrera, Ever A; Hernandez-Alemon, Aldo N; Tovar-Vargas, Maria de Los A; Serrano-Pinto, Yamile G; Espejo-Ortiz, Cristian E; Morales-Ortega, Maria de la L; Lozano-Cruz, Oscar A; Cardenas-Fragoso, Jose L; Vidal-Mayo, Jose de J; Hernandez-Gilsoul, Thierry; Rivero-Sigarroa, Eduardo; Dominguez-Cherit, Guillermo; Cervantes-Villar, Luz E; Ramos-Cervantes, Maria Del P; Ibarra-Gonzalez, Violeta; Calva-Mercado, Juan J; Sierra-Madero, Juan G; Lopez-Iniguez, Alvaro; Ochoa-Hein, Eric; Crabtree-Ramirez, Brenda E; Galindo-Fraga, Arturo; Guerrero-Almeida, Maria de L; Ruiz-Palacios, Guillermo M; Gulias-Herrero, Alfonso; Sifuentes-Osornio, Jose; Kershenobich-Stalnikowitz, David; Ponce-de-Leon, Alfredo.
+Institution
+ Ortiz-Brizuela, Edgar. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Villanueva-Reza, Marco. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Gonzalez-Lara, Maria F. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Tamez-Torres, Karla M. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Roman-Montes, Carla M. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Diaz-Mejia, Bruno A. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Perez-Garcia, Esteban. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Olivas-Martinez, Antonio. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Rajme-Lopez, Sandra. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Martinez-Guerra, Bernardo A. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ de-Leon-Cividanes, Nereyda A. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Fernandez-Garcia, Oscar A. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Guerrero-Torres, Lorena. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Torres-Gonzalez, Lorena. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Carrera-Patino, Fabian A. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Corral-Herrera, Ever A. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Hernandez-Alemon, Aldo N. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Tovar-Vargas, Maria de Los A. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Serrano-Pinto, Yamile G. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Espejo-Ortiz, Cristian E. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Morales-Ortega, Maria de la L. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Lozano-Cruz, Oscar A. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Cardenas-Fragoso, Jose L. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Vidal-Mayo, Jose de J. Department of Emergency, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Hernandez-Gilsoul, Thierry. Department of Emergency, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Rivero-Sigarroa, Eduardo. Department of Critical Care Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Dominguez-Cherit, Guillermo. Department of Critical Care Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Cervantes-Villar, Luz E. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Ramos-Cervantes, Maria Del P. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Ibarra-Gonzalez, Violeta. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Calva-Mercado, Juan J. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Sierra-Madero, Juan G. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Lopez-Iniguez, Alvaro. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Ochoa-Hein, Eric. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Crabtree-Ramirez, Brenda E. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Galindo-Fraga, Arturo. Department of Hospital Epidemiology; and Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Guerrero-Almeida, Maria de L. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Ruiz-Palacios, Guillermo M. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Gulias-Herrero, Alfonso. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Sifuentes-Osornio, Jose. Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Kershenobich-Stalnikowitz, David. Department of General Director's Office, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+ Ponce-de-Leon, Alfredo. Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
+Comments
+ Erratum in (EIN)
+ Comment in (CIN)
+MeSH Subject Headings
+ Abdominal Pain/ep [Epidemiology]
+ Adult
+ Aged
+ Ambulatory Care
+ *Betacoronavirus
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ COVID-19
+ Comorbidity
+ Coronavirus Infections/co [Complications]
+ *Coronavirus Infections/ep [Epidemiology]
+ Coronavirus Infections/th [Therapy]
+ Critical Care
+ Dyspnea/et [Etiology]
+ Female
+ Gastrointestinal Diseases/ep [Epidemiology]
+ Humans
+ Inpatients/sn [Statistics & Numerical Data]
+ Male
+ Mexico
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Outpatients/sn [Statistics & Numerical Data]
+ *Pandemics
+ Pneumonia, Viral/co [Complications]
+ *Pneumonia, Viral/ep [Epidemiology]
+ Pneumonia, Viral/th [Therapy]
+ SARS-CoV-2
+ Severity of Illness Index
+ Tertiary Care Centers/sn [Statistics & Numerical Data]
+ Treatment Outcome
+Keyword Heading
+ 2019-novel coronavirus
+ Cohort
+ Coronavirus
+ Coronavirus disease-2019
+ Mexico
+ Severe acute respiratory syndrome coronavirus 2
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding of the pandemic.
+
+ OBJECTIVE: The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC).
+
+ METHODS: We conducted a prospective cohort, including consecutive patients with COVID-19 from February 26, 2020 to April 11, 2020.
+
+ RESULTS: We identified 309 patients (140 inpatients and 169 outpatients). The median age was 43 years (interquartile range, 33-54), 59.2% men, and 18.6% healthcare workers (12.3% from our center). The median body mass index (BMI) was 29.00 kg/m2 and 39.6% had obesity. Compared to outpatients, inpatients were older, had comorbidities, cough, and dyspnea more frequently. Twenty-nine (20.7%) inpatients required treatment in the IC unit (ICU). History of diabetes (type 1 or 2) and abdominal pain were more common in ICU patients compared to non-ICU patients. ICU patients had higher BMIs, higher respiratory rates, and lower room-air capillary oxygen saturations. ICU patients showed a more severe inflammatory response as assessed by white blood cell count, neutrophil and platelet count, C-reactive protein, ferritin, procalcitonin, and albumin levels. By the end of the study period, 65 inpatients had been discharged because of improvement, 70 continued hospitalized, and five had died.
+
+ CONCLUSIONS: Patients with comorbidities, either middle-age obese or elderly complaining of fever, cough, or dyspnea, were more likely to be admitted. At admission, patients with diabetes, high BMI, and clinical or laboratory findings consistent with a severe inflammatory state were more likely to require IC. Copyright: © 2020 Permanyer.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.24875%2fRIC.20000211
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ortiz-Brizuela&issn=0034-8376&title=Revista+de+Investigacion+Clinica&atitle=CLINICAL+AND+EPIDEMIOLOGICAL+CHARACTERISTICS+OF+PATIENTS+DIAGNOSED+WITH+COVID-19+IN+A+TERTIARY+CARE+CENTER+IN+MEXICO+CITY%3A+A+PROSPECTIVE+COHORT+STUDY.&volume=72&issue=3&spage=165&epage=177&date=2020&doi=10.24875%2FRIC.20000211&pmid=32584326&sid=OVID:medline
+
+<1279>
+Unique Identifier
+ 32576204
+Title
+ The value of the atherogenic index of plasma in non-obese people with non-alcoholic fatty liver disease: a secondary analysis based on a cross-sectional study.
+Source
+ Lipids in Health & Disease. 19(1):148, 2020 Jun 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dong BY; Mao YQ; Li ZY; Yu FJ
+Author NameID
+ Yu, Fu-Jun; ORCID: http://orcid.org/0000-0001-5321-7228
+Authors Full Name
+ Dong, Bu-Yuan; Mao, Yu-Qing; Li, Zheng-Yang; Yu, Fu-Jun.
+Institution
+ Dong, Bu-Yuan. Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, PR China.
+ Mao, Yu-Qing. Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
+ Li, Zheng-Yang. Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai, 201508, China. noyes8002@126.com.
+ Yu, Fu-Jun. Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, PR China. tjyufujun@163.com.
+MeSH Subject Headings
+ Adult
+ Asian People
+ *Atherosclerosis/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Incidence
+ Male
+ Middle Aged
+ Multivariate Analysis
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Obesity/bl [Blood]
+Keyword Heading
+ Atherogenic index of plasma
+ Correlation
+ Non-alcoholic fatty liver disease
+ Non-obese patients
+ Odds ratio
+ Receiver operating characteristic curve
+ Risk factor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND OBJECTIVES: The atherogenic index of plasma (AIP) is elevated in fatty liver disease, but its value in non-obese people with non-alcoholic fatty liver disease (NAFLD) is unclear. This study aimed to investigate the relationship between AIP and NAFLD as well as to determine whether AIP might be used as an indicator of NAFLD in non-obese individuals.
+
+ METHODS: The present study involved non-obese Chinese and Japanese participants. Risk factors are evaluated using univariate and multivariate analysis. The performance of risk factors was compared according to the area under the receiver operating characteristic curve.
+
+ RESULTS: In the unadjusted model, the odds ratio (OR) for every 1 standard deviation (SD) increase in AIP was 52.30. In adjusted models I and II, the OR for every 1 SD increase in AIP was 36.57 and 50.84, respectively. The area under the receiver operating characteristic curve for AIP was 0.803 and 0.802 in the development and validation groups, respectively. The best cut-off value of AIP for discrimination between NAFLD and non-NAFLD was 0.005 in the Chinese group and - 0.220 in the Japanese group.
+
+ CONCLUSIONS: AIP and NAFLD are positively correlated in Chinese and Japanese populations. Therefore, AIP can be used as a new screening indicator for non-obese people with NAFLD in different nations.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12944-020-01319-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dong&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=The+value+of+the+atherogenic+index+of+plasma+in+non-obese+people+with+non-alcoholic+fatty+liver+disease%3A+a+secondary+analysis+based+on+a+cross-sectional+study.&volume=19&issue=1&spage=148&epage=&date=2020&doi=10.1186%2Fs12944-020-01319-2&pmid=32576204&sid=OVID:medline
+
+<1280>
+Unique Identifier
+ 32571615
+Title
+ Prevalence of poor lipid control in patients with premature coronary artery disease.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(10):1697-1705, 2020 09 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Froylan D MS; Esteban JG; Carlos PR; Aida X MU; Ma Rocio MA; Horacio OA; Juan G JR
+Authors Full Name
+ Froylan D, Martinez-Sanchez; Esteban, Jorge-Galarza; Carlos, Posadas-Romero; Aida X, Medina-Urrutia; Ma Rocio, Martinez-Alvarado; Horacio, Osorio-Alonso; Juan G, Juarez-Rojas.
+Institution
+ Froylan D, Martinez-Sanchez. Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Seccion XVI, C.P. 14080, Tlalpan, Mexico City, Mexico. Electronic address: froylan.martinez@anahuac.mx.
+ Esteban, Jorge-Galarza. Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Seccion XVI, C.P. 14080, Tlalpan, Mexico City, Mexico. Electronic address: esjoga@yahoo.com.mx.
+ Carlos, Posadas-Romero. Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Seccion XVI, C.P. 14080, Tlalpan, Mexico City, Mexico. Electronic address: cposadasr@yahoo.com.
+ Aida X, Medina-Urrutia. Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Seccion XVI, C.P. 14080, Tlalpan, Mexico City, Mexico. Electronic address: aidaxm@yahoo.com.
+ Ma Rocio, Martinez-Alvarado. Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Seccion XVI, C.P. 14080, Tlalpan, Mexico City, Mexico. Electronic address: orssino@yahoo.com.
+ Horacio, Osorio-Alonso. Department of Cardio-Renal Physiopathology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico. Electronic address: horace_33@yahoo.com.mx.
+ Juan G, Juarez-Rojas. Department of Endocrinology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Seccion XVI, C.P. 14080, Tlalpan, Mexico City, Mexico. Electronic address: gaboyk2@gmail.com.
+MeSH Subject Headings
+ Age of Onset
+ Aged
+ Apolipoprotein B-100/bl [Blood]
+ Biomarkers/bl [Blood]
+ Cholesterol, LDL/bl [Blood]
+ Coronary Artery Disease/di [Diagnosis]
+ Coronary Artery Disease/ep [Epidemiology]
+ *Coronary Artery Disease/pc [Prevention & Control]
+ Cross-Sectional Studies
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ *Dyslipidemias/dt [Drug Therapy]
+ Dyslipidemias/ep [Epidemiology]
+ Female
+ Humans
+ *Hydroxymethylglutaryl-CoA Reductase Inhibitors/tu [Therapeutic Use]
+ *Lipids/bl [Blood]
+ Male
+ Medication Adherence
+ Mexico/ep [Epidemiology]
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Practice Patterns, Physicians'
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Treatment Outcome
+Keyword Heading
+ Apolipoprotein B-100
+ Lipid control
+ Low-density lipoprotein cholesterol
+ Non-high-density lipoprotein cholesterol
+ Premature coronary artery disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Lipid goals have become more stringent in high risk patients. However, no studies have analyzed lipid control defined as the composite achievement of goals in low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (Non-HDL-C) and apolipoproteinB-100 (ApoB-100), in patients with premature coronary artery disease (CAD). We aimed to analyze lipid control rates, and the associated factors with its poor achievement in patients with premature CAD.
+
+ METHODS AND RESULTS: The study included 1196 patients with CAD diagnosed before 55 and 65 years old in men and women, respectively. The American Heart Association/American College of Cardiology (non-strict) and the American Association of Clinical Endocrinologists (strict) criteria were used to analyze lipid control rates. Sociodemographic, dietary-healthy and clinical characteristics of the patients were collected. Participants were 54 +/- 8 years old, 19.7% were women, and median CAD evolution was 2.4 years. Non-strict and strict lipid control was achieved in 23.0% and 8.9% of the patients, respectively. Moreover, 46.5% and 62.8% of the patients did not achieve any lipid goal using both criteria. Sociodemographic data were not different among patients who achieved or not lipid control. Treatment adherence<85%, prescription of low- and moderate-intensity statins, and obesity were consistently associated with poor lipid control.
+
+ CONCLUSIONS: Lipid control is suboptimal in patients with premature CAD. Low lipid-lowering treatment adherence, low prescription of high-intensity statins, and obesity were independently associated with poor lipid control. Novel preventive programs and more aggressive pharmacological intervention should be implemented in order to reduce the burden of premature CAD. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (APOB protein, human). 0 (Apolipoprotein B-100). 0 (Biomarkers). 0 (Cholesterol, LDL). 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors). 0 (Lipids).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.numecd.2020.04.030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Froylan+D&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Prevalence+of+poor+lipid+control+in+patients+with+premature+coronary+artery+disease.&volume=30&issue=10&spage=1697&epage=1705&date=2020&doi=10.1016%2Fj.numecd.2020.04.030&pmid=32571615&sid=OVID:medline
+
+<1281>
+Unique Identifier
+ 32570947
+Title
+ Postprandial Endotoxin Transporters LBP and sCD14 Differ in Obese vs. Overweight and Normal Weight Men during Fat-Rich Meal Digestion.
+Source
+ Nutrients. 12(6), 2020 Jun 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Laugerette F; Vors C; Alligier M; Pineau G; Drai J; Knibbe C; Morio B; Lambert-Porcheron S; Laville M; Vidal H; Michalski MC
+Author NameID
+ Alligier, Maud; ORCID: https://orcid.org/0000-0002-2864-7741
+Authors Full Name
+ Laugerette, Fabienne; Vors, Cecile; Alligier, Maud; Pineau, Gaelle; Drai, Jocelyne; Knibbe, Carole; Morio, Beatrice; Lambert-Porcheron, Stephanie; Laville, Martine; Vidal, Hubert; Michalski, Marie-Caroline.
+Institution
+ Laugerette, Fabienne. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Vors, Cecile. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Alligier, Maud. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Alligier, Maud. Centre de Recherche en Nutrition Humaine Rhone-Alpes, Univ-Lyon, CarMeN Laboratory, Universite Claude Bernard Lyon1, Hospices Civils de Lyon, CENS, FCRIN/FORCE Network, 69310 Pierre-Benite, France.
+ Pineau, Gaelle. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Drai, Jocelyne. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Drai, Jocelyne. Laboratoire de Biochimie, Centre Hospitalier Lyon Sud, 69600 Oullins, France.
+ Knibbe, Carole. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Morio, Beatrice. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Morio, Beatrice. Centre de Recherche en Nutrition Humaine Rhone-Alpes, Univ-Lyon, CarMeN Laboratory, Universite Claude Bernard Lyon1, Hospices Civils de Lyon, CENS, FCRIN/FORCE Network, 69310 Pierre-Benite, France.
+ Lambert-Porcheron, Stephanie. Centre de Recherche en Nutrition Humaine Rhone-Alpes, Univ-Lyon, CarMeN Laboratory, Universite Claude Bernard Lyon1, Hospices Civils de Lyon, CENS, FCRIN/FORCE Network, 69310 Pierre-Benite, France.
+ Lambert-Porcheron, Stephanie. Hospices Civils de Lyon, 69000 Lyon, France.
+ Laville, Martine. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Laville, Martine. Centre de Recherche en Nutrition Humaine Rhone-Alpes, Univ-Lyon, CarMeN Laboratory, Universite Claude Bernard Lyon1, Hospices Civils de Lyon, CENS, FCRIN/FORCE Network, 69310 Pierre-Benite, France.
+ Laville, Martine. Hospices Civils de Lyon, 69000 Lyon, France.
+ Vidal, Hubert. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Vidal, Hubert. Centre de Recherche en Nutrition Humaine Rhone-Alpes, Univ-Lyon, CarMeN Laboratory, Universite Claude Bernard Lyon1, Hospices Civils de Lyon, CENS, FCRIN/FORCE Network, 69310 Pierre-Benite, France.
+ Vidal, Hubert. Hospices Civils de Lyon, 69000 Lyon, France.
+ Michalski, Marie-Caroline. Univ Lyon, CarMeN Laboratory, INRAE, UMR1397, INSERM, UMR1060, Universite Claude Bernard Lyon 1, 69310 Pierre Benite, France.
+ Michalski, Marie-Caroline. Centre de Recherche en Nutrition Humaine Rhone-Alpes, Univ-Lyon, CarMeN Laboratory, Universite Claude Bernard Lyon1, Hospices Civils de Lyon, CENS, FCRIN/FORCE Network, 69310 Pierre-Benite, France.
+MeSH Subject Headings
+ Acute-Phase Proteins/ge [Genetics]
+ Adult
+ Biomarkers/bl [Blood]
+ *Body Weight
+ *Carrier Proteins/bl [Blood]
+ Carrier Proteins/ge [Genetics]
+ Cross-Over Studies
+ *Diet, High-Fat/ae [Adverse Effects]
+ Humans
+ *Lipopolysaccharide Receptors/bl [Blood]
+ Lipopolysaccharide Receptors/ge [Genetics]
+ Male
+ *Membrane Glycoproteins/bl [Blood]
+ Membrane Glycoproteins/ge [Genetics]
+ Obesity/bl [Blood]
+ *Overweight/bl [Blood]
+ *Postprandial Period
+Keyword Heading
+ LBP
+ high-fat diet
+ postprandial kinetics
+ sCD14
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Circulating levels of lipopolysaccharide-binding protein (LBP) and soluble cluster of differentiation 14 (sCD14) are recognized as clinical markers of endotoxemia. In obese men, postprandial endotoxemia is modulated by the amount of fat ingested, being higher compared to normal-weight (NW) subjects. Relative variations of LBP/sCD14 ratio in response to overfeeding are also considered important in the inflammation set-up, as measured through IL-6 concentration. We tested the hypothesis that postprandial LBP and sCD14 circulating concentrations differed in obese vs. overweight and NW men after a fat-rich meal. We thus analyzed the postprandial kinetics of LBP and sCD14 in the context of two clinical trials involving postprandial tests in normal-, over-weight and obese men. In the first clinical trial eight NW and 8 obese men ingested breakfasts containing 10 vs. 40 g of fat. In the second clinical trial, 18 healthy men were overfed during 8 weeks. sCD14, LBP and Il-6 were measured in all subjects during 5 h after test meal. Obese men presented a higher fasting and postprandial LBP concentration in plasma than NW men regardless of fat load, while postprandial sCD14 was similar in both groups. Irrespective of the overfeeding treatment, we observed postprandial increase of sCD14 and decrease of LBP before and after OF. In obese individuals receiving a 10 g fat load, whereas IL-6 increased 5h after meal, LBP and sCD14 did not increase. No direct association between the postprandial kinetics of endotoxemia markers sCD14 and LBP and of inflammation in obese men was observed in this study.
+Registry Number/Name of Substance
+ 0 (Acute-Phase Proteins). 0 (Biomarkers). 0 (CD14 protein, human). 0 (Carrier Proteins). 0 (Lipopolysaccharide Receptors). 0 (Membrane Glycoproteins). 0 (lipopolysaccharide-binding protein).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12061820
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Laugerette&issn=2072-6643&title=Nutrients&atitle=Postprandial+Endotoxin+Transporters+LBP+and+sCD14+Differ+in+Obese+vs.+Overweight+and+Normal+Weight+Men+during+Fat-Rich+Meal+Digestion.&volume=12&issue=6&spage=&epage=&date=2020&doi=10.3390%2Fnu12061820&pmid=32570947&sid=OVID:medline
+
+<1282>
+Unique Identifier
+ 32566274
+Title
+ Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review.
+Source
+ Journal of Obesity. 2020:6134362, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Endalifer ML; Diress G
+Author NameID
+ Endalifer, Melese Linger; ORCID: https://orcid.org/0000-0003-1505-2500
+ Diress, Gedefaw; ORCID: https://orcid.org/0000-0002-8616-0034
+Authors Full Name
+ Endalifer, Melese Linger; Diress, Gedefaw.
+Institution
+ Endalifer, Melese Linger. College of Health Sciences, Woldia University, Woldia, Ethiopia.
+ Diress, Gedefaw. College of Health Sciences, Woldia University, Woldia, Ethiopia.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Humans
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Obesity/et [Etiology]
+ Obesity/pc [Prevention & Control]
+ Risk Factors
+Abstract
+ Background. Globally, obesity is becoming a public health problem in the general population. Various determinants were reported by different scholars even though there are inconsistencies. Different biomarkers of obesity were identified for the prediction of obesity. Even though researchers speculate the factors, biomarkers, consequences, and prevention mechanisms, there is a lack of aggregate and purified data in the area of obesity. Summary. In this review, the epidemiology, predisposing factors, biomarkers, consequences, and prevention approaches of obesity were reviewed. Key Messages. The epidemiology of obesity increased in low-, middle-, and high-income countries. Even if the factors vary across regions and socioeconomic levels, sociodemographic, behavioral, and genetic factors were prominent for the development of obesity. There are a lot of biomarkers for obesity, of which microRNA, adipocytes, oxidative stress, blood cell profile, nutrients, and microbiota were promising biomarkers for determination of occurrence of obesity. Since the consequences of obesity are vast and interrelated, multidimensional prevention strategy is mandatory in all nations. Copyright © 2020 Melese Linger Endalifer and Gedefaw Diress.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1155%2f2020%2f6134362
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Endalifer&issn=2090-0708&title=Journal+of+Obesity&atitle=Epidemiology%2C+Predisposing+Factors%2C+Biomarkers%2C+and+Prevention+Mechanism+of+Obesity%3A+A+Systematic+Review.&volume=2020&issue=&spage=6134362&epage=&date=2020&doi=10.1155%2F2020%2F6134362&pmid=32566274&sid=OVID:medline
+
+<1283>
+Unique Identifier
+ 32564583
+Title
+ Low serum copper and zinc concentrations in North Indian children with overweight and obesity.
+Original Title
+ Niskie stezenie miedzi i cynku w surowicy u dzieci z polnocnej Indii z nadwaga i otyloscia.
+Source
+ Pediatric endocrinology, diabetes, & metabolism. 26(2):79-83, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vivek SM; Dayal D; Khaiwal R; Bharti B; Bhalla A; Singh S; Kaur H; Attri SV
+Authors Full Name
+ Vivek, Singh Malik; Dayal, Devi; Khaiwal, Ravindra; Bharti, Bhavneet; Bhalla, Anil; Singh, Satwinder; Kaur, Harvinder; Attri, Savita Verma.
+Institution
+ Vivek, Singh Malik. Department of Community Medicine and School of Public Health, Chandigarh, India
+ Vivek, Singh Malik. Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
+ Dayal, Devi. Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
+ Khaiwal, Ravindra. Department of Community Medicine and School of Public Health, Chandigarh, India
+ Bharti, Bhavneet. Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
+ Bhalla, Anil. Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
+ Singh, Satwinder. Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
+ Kaur, Harvinder. Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
+ Attri, Savita Verma. Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ Blood Chemical Analysis
+ Child
+ *Copper/bl [Blood]
+ Female
+ Humans
+ Male
+ *Obesity/bl [Blood]
+ *Overweight/bl [Blood]
+ *Zinc/bl [Blood]
+Keyword Heading
+ childhood obesity
+ copper
+ ratio
+ whole blood
+ zinc
+ serum
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: There are limited data on the alterations of serum copper and zinc, which have been proposed to have associations among children with obesity.
+
+ MATERIAL AND METHODS: A total of 173 children were enrolled and grouped into overweight/obese (n = 69) and non-obese (n = 104) according to CDC 2000 growth charts. Serum and whole blood zinc and copper concentrations were measured by validated ICP-MS method, and copper/zinc ratios were calculated and correlated to various anthropometric parameters.
+
+ RESULTS: Mean BMI in obese (24.78 +/-3.93) was significantly higher as compared to non-obese (16.44 +/-2.34; p < 0.0001, 95% CI: 15.9873-16.8998) children. Mean serum copper levels in obese children (1099.80 +/-478.67 microg/l) were significantly lower than for non-obese children (2063.77 +/-1006.81 microg/l; p = 0.0001, 95% CI: 1867.9755-2259.5755). Similarly, the mean serum zinc levels in obese children (851.53 +/-406.33 microg/l) were also significantly lower as compared to non-obese children (1528.72 +/-796.82 microg/l; p = 0.0001, 95% CI: 1373.76-1683.6879). Mean whole blood copper levels were significantly lower in obese (929.56 +/-200.15 microg/l) as compared to non-obese (1393.22 +/-861.92 microg/l; p = 0.0001, 95% CI: 1225.6023-1560.8481) children. Similarly, the mean whole blood zinc levels in obese (4384.11 +/-881.87 microg/l) were also significantly lower as compared to non-obese (5380.14 +/-2236.77 microg/l; p = 0.001, 95% CI: 4945.1491-5815.1416) children.
+
+ CONCLUSIONS: The serum and whole blood concentrations of zinc and copper were found to be significantly lower in children with exogenous obesity as compared to controls. Additional investigations are recommended to see the underlying aspect of these elements in the development of obesity along with their co-morbidities.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 789U1901C5 (Copper). J41CSQ7QDS (Zinc).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.5114%2fpedm.2020.95627
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vivek&issn=2083-8441&title=Pediatric+endocrinology%2C+diabetes%2C+%26+metabolism&atitle=Niskie+stezenie+miedzi+i+cynku+w+surowicy+u+dzieci+z+polnocnej+Indii+z+nadwaga+i+otyloscia.&volume=26&issue=2&spage=79&epage=83&date=2020&doi=10.5114%2Fpedm.2020.95627&pmid=32564583&sid=OVID:medline
+
+<1284>
+Unique Identifier
+ 32564244
+Title
+ GlycA, a novel marker for low grade inflammation, reflects gut microbiome diversity and is more accurate than high sensitive CRP in reflecting metabolomic profile.
+Source
+ Metabolomics. 16(7):76, 2020 06 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mokkala K; Houttu N; Koivuniemi E; Sorensen N; Nielsen HB; Laitinen K
+Author NameID
+ Mokkala, Kati; ORCID: https://orcid.org/0000-0002-0354-5546
+ Houttu, Noora; ORCID: https://orcid.org/0000-0002-1350-2187
+ Koivuniemi, Ella; ORCID: https://orcid.org/0000-0002-5751-3064
+ Nielsen, Henrik Bjorn; ORCID: https://orcid.org/0000-0003-2281-5713
+ Laitinen, Kirsi; ORCID: https://orcid.org/0000-0001-5245-8118
+Authors Full Name
+ Mokkala, Kati; Houttu, Noora; Koivuniemi, Ella; Sorensen, Nikolaj; Nielsen, Henrik Bjorn; Laitinen, Kirsi.
+Institution
+ Mokkala, Kati. Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20014, Turku, Finland. kamamo@utu.fi.
+ Houttu, Noora. Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20014, Turku, Finland.
+ Koivuniemi, Ella. Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20014, Turku, Finland.
+ Sorensen, Nikolaj. Clinical Microbiomics, Copenhagen, Denmark.
+ Nielsen, Henrik Bjorn. Clinical Microbiomics, Copenhagen, Denmark.
+ Laitinen, Kirsi. Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20014, Turku, Finland.
+ Laitinen, Kirsi. Department of Obstetrics and Gynecology, Turku University Hospital, 20521, Turku, Finland.
+MeSH Subject Headings
+ Acetylglucosamine/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/me [Metabolism]
+ Cross-Sectional Studies
+ Feces/ch [Chemistry]
+ Female
+ Fibrinogen/me [Metabolism]
+ *Gastrointestinal Microbiome/ph [Physiology]
+ Glycoproteins/bl [Blood]
+ Haptoglobins/me [Metabolism]
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/me [Metabolism]
+ Metabolomics/mt [Methods]
+ Obesity/bl [Blood]
+ Obesity/me [Metabolism]
+ Pregnancy
+ Serum Amyloid A Protein/me [Metabolism]
+Keyword Heading
+ GlycA
+ Gut microbiome diversity
+ Low grade inflammation
+ Metabolomics
+ hsCRP
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Gut microbiota is, along with adipose tissue, recognized as a source for many metabolic and inflammatory disturbances that may contribute to the individual's state of health.
+
+ OBJECTIVES: We investigated in cross-sectional setting the feasibility of utilizing GlycA, a novel low grade inflammatory marker, and traditional low grade inflammatory marker, high sensitivity CRP (hsCRP), in reflecting serum metabolomics status and gut microbiome diversity.
+
+ METHODS: Fasting serum samples of overweight/obese pregnant women (n = 335, gestational weeks: mean 13.8) were analysed for hsCRP by immunoassay, GlycA and metabolomics status by NMR metabolomics and faecal samples for gut microbiome diversity by metagenomics. The benefits of GlycA as a metabolic marker were investigated against hsCRP.
+
+ RESULTS: The GlycA concentration correlated with more of the metabolomics markers (144 out of 157), than hsCRP (55 out of 157) (FDR < 0.05). The results remained essentially the same when potential confounding factors known to associate with GlycA and hsCRP levels were taken into account (P < 0.05). This was attributable to the detected correlations between GlycA and the constituents and concentrations of several sized VLDL-particles and branched chain amino acids, which were statistically non-significant with regard to hsCRP. GlycA, but not hsCRP, correlated inversely with gut microbiome diversity.
+
+ CONCLUSION: GlycA is a superior marker than hsCRP in assessing the metabolomic profile and gut microbiome diversity. It is proposed that GlycA may act as a novel marker that reflects both the gut microbiome and adipose tissue originated metabolic aberrations; this proposal will need to be verified with regard to clinical outcomes.
+
+ CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT01922791, August 14, 2013.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycoproteins). 0 (HP protein, human). 0 (Haptoglobins). 0 (Serum Amyloid A Protein). 9001-32-5 (Fibrinogen). 9007-41-4 (C-Reactive Protein). V956696549 (Acetylglucosamine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs11306-020-01695-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mokkala&issn=1573-3882&title=Metabolomics&atitle=GlycA%2C+a+novel+marker+for+low+grade+inflammation%2C+reflects+gut+microbiome+diversity+and+is+more+accurate+than+high+sensitive+CRP+in+reflecting+metabolomic+profile.&volume=16&issue=7&spage=76&epage=&date=2020&doi=10.1007%2Fs11306-020-01695-x&pmid=32564244&sid=OVID:medline
+
+<1285>
+Unique Identifier
+ 32563939
+Title
+ Association of Meteorin-Like Hormone with insulin resistance and body composition in healthy Iranian adults.
+Source
+ Diabetes & Metabolic Syndrome. 14(5):881-885, 2020 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alizadeh H; Alizadeh A
+Authors Full Name
+ Alizadeh, Hamid; Alizadeh, Aliakbar.
+Institution
+ Alizadeh, Hamid. Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran. Electronic address: h.alizadeh.aw@gmail.com.
+ Alizadeh, Aliakbar. Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Electronic address: aliakbar.alizadeh1984@gmail.com.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ *Body Composition
+ *Body Mass Index
+ Case-Control Studies
+ Exercise
+ Follow-Up Studies
+ Healthy Volunteers
+ Humans
+ *Insulin Resistance
+ Iran
+ *Life Style
+ Male
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Sedentary Behavior
+ Young Adult
+Keyword Heading
+ Body composition
+ Healthy humans
+ Insulin resistance
+ Metrnl
+ RPA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Sedentary behavior and/or physical inactivity are modifiable risk factors for noncommunicable diseases. Myokines are one of the mediators of physical activity health benefits. Relationship between regular physical activity (RPA) and baseline plasma Meteorin-Like Hormone (Metrnl) has not been explored in human. Hence, we compared baseline plasma Metrnl between sedentary individuals and ones with recreational physical activities, and role of Metrnl as a biological messenger between physical activity and insulin resistance and body composition was also explored.
+
+ METHODS: Forty healthy young men (aged: 21 +/- 2.1 yrs; BMI: 23 +/- 3.44 kg/m2) completed the study. Participants were equally assigned into two groups of control (sedentary) and case (recreational athletes). Baseline plasma Metrnl, glucose, insulin and body composition components and insulin resistance index (HOMA-IR) were assessed under resting conditions.
+
+ RESULTS: Except for baseline blood glucose, baseline plasma Metrnl, insulin, HOMA-IR and body mass index and body fat percentage were similar between two groups (P > 0.05). However, after Metrnl correction for the degree of insulin resistance index (Metrnl/HOMA-IR), recreational athletes showed a significantly greater baseline compared to sedentary subjects (P < 0.05). Baseline blood glucose showed a negative and significant correlation with baseline plasma Metrnl (P < 0.05).
+
+ CONCLUSIONS: Baseline plasma Metrnl is correlated with regular physical activity and insulin sensitivity, but not with body composition parameters. Metrnl may be one possible mediator of the beneficial effects of PA on insulin sensitivity in healthy humans. Hence, increasing awareness of the benefits of physical activity and incorporating physical activity into lifestyle are of great importance for people with non-communicable diseases. Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Blood Glucose). 0 (Metrnl protein, human).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.dsx.2020.05.031
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alizadeh&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+of+Meteorin-Like+Hormone+with+insulin+resistance+and+body+composition+in+healthy+Iranian+adults.&volume=14&issue=5&spage=881&epage=885&date=2020&doi=10.1016%2Fj.dsx.2020.05.031&pmid=32563939&sid=OVID:medline
+
+<1286>
+Unique Identifier
+ 32544463
+Title
+ A single session of physical activity restores the mitochondrial organization disrupted by obesity in skeletal muscle fibers.
+Source
+ Life Sciences. 256:117965, 2020 Sep 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rivera-Alvarez I; Perez-Trevino P; Chapoy-Villanueva H; Vela-Guajardo JE; Nieblas B; Garza-Gonzalez S; Garcia-Rivas G; Garcia N
+Authors Full Name
+ Rivera-Alvarez, Irais; Perez-Trevino, Perla; Chapoy-Villanueva, Hector; Vela-Guajardo, Jorge E; Nieblas, Bianca; Garza-Gonzalez, Salvador; Garcia-Rivas, Gerardo; Garcia, Noemi.
+Institution
+ Rivera-Alvarez, Irais. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, San Pedro Garza Garcia, NL, Mexico.
+ Perez-Trevino, Perla. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, San Pedro Garza Garcia, NL, Mexico.
+ Chapoy-Villanueva, Hector. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, San Pedro Garza Garcia, NL, Mexico.
+ Vela-Guajardo, Jorge E. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, San Pedro Garza Garcia, NL, Mexico.
+ Nieblas, Bianca. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, San Pedro Garza Garcia, NL, Mexico.
+ Garza-Gonzalez, Salvador. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, San Pedro Garza Garcia, NL, Mexico.
+ Garcia-Rivas, Gerardo. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, San Pedro Garza Garcia, NL, Mexico; Centro de Investigacion Biomedica, Hospital Zambrano-Hellion, San Pedro Garza Garcia, NL, Mexico.
+ Garcia, Noemi. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, San Pedro Garza Garcia, NL, Mexico; Centro de Investigacion Biomedica, Hospital Zambrano-Hellion, San Pedro Garza Garcia, NL, Mexico. Electronic address: garcianr@tec.mx.
+MeSH Subject Headings
+ Adenylate Kinase/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Citrate (si)-Synthase/me [Metabolism]
+ DNA, Mitochondrial/me [Metabolism]
+ Gene Expression Regulation
+ Male
+ Membrane Potential, Mitochondrial
+ *Mitochondria/pa [Pathology]
+ Mitochondrial Dynamics
+ Mitochondrial Proteins/ge [Genetics]
+ Mitochondrial Proteins/me [Metabolism]
+ *Muscle Fibers, Skeletal/pa [Pathology]
+ *Obesity/pa [Pathology]
+ Organ Size
+ Oxidative Stress
+ Phosphorylation
+ *Physical Conditioning, Animal
+ Rats, Zucker
+Keyword Heading
+ AMPK
+ Metabolic syndrome
+ Mitochondria quality control
+ Mitochondrial dynamics
+ Oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Several studies have proved that physical activity (PA) regulates energetic metabolism associated with mitochondrial dynamics through AMPK activation in healthy subjects. Obesity, a condition that induces oxidative stress, mitochondrial dysfunction, and low AMPK activity leads to mitochondrial fragmentation. However, few studies describe the effect of PA on mitochondrial dynamics regulation in obesity.
+
+ AIM: The present study aimed to evaluate the effect of a single session of PA on mitochondrial dynamics regulation as well as its effect on mitochondrial function and organization in skeletal muscles of obese rats (Zucker fa/fa).
+
+ MAIN METHODS: Male Zucker lean and Zucker fa/fa rats aged 12 to 13 weeks were divided into sedentary and subjected-to-PA (single session swimming) groups. Gastrocnemius muscle was dissected into isolated fibers, mitochondria, mRNA, and total proteins for their evaluation.
+
+ KEY FINDINGS: The results showed that PA increased the Mfn-2 protein level in the lean and obese groups, whereas Drp1 levels decreased in the obese group. OMA1 protease levels increased in the lean group and decreased in the obese group. Additionally, AMPK analysis parameters (expression, protein level, and activity) did not increase in the obese group. These findings correlated with the partial restoration of mitochondrial function in the obese group, increasing the capacity to maintain the membrane potential after adding calcium as a stressor, and increasing the transversal organization level of the mitochondria analyzed in isolated fibers.
+
+ SIGNIFICANCE: These results support the notion that obese rats subjected to PA maintain mitochondrial function through mitochondrial fusion activation by an AMPK-independent mechanism. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (DNA, Mitochondrial). 0 (Mitochondrial Proteins). EC 2-3-3-1 (Citrate (si)-Synthase). EC 2-7-4-3 (Adenylate Kinase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.lfs.2020.117965
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rivera-Alvarez&issn=0024-3205&title=Life+Sciences&atitle=A+single+session+of+physical+activity+restores+the+mitochondrial+organization+disrupted+by+obesity+in+skeletal+muscle+fibers.&volume=256&issue=&spage=117965&epage=&date=2020&doi=10.1016%2Fj.lfs.2020.117965&pmid=32544463&sid=OVID:medline
+
+<1287>
+Unique Identifier
+ 32540811
+Title
+ [Leptin and adiponectin's evaluations in France: what place in clinical practice?]. [French]
+Original Title
+ Leptine et adiponectine : deux actes RIHN, quelle place en pratique ?
+Source
+ Annales de Biologie Clinique. 78(3):229-230, 2020 06 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bastard JP; Peoc'h K
+Authors Full Name
+ Bastard, Jean-Philippe; Peoc'h, Katell.
+Institution
+ Bastard, Jean-Philippe. Sorbonne Universite, Inserm UMR_S 938, Centre de recherche Saint-Antoine, Institut hospitalo-universitaire de cardio-metabolisme et nutrition (ICAN), Paris, France, Hopital Tenon, AP-HP, Service de biochimie et hormonologie, UF Bio-marqueurs inflammatoires et metaboliques, Paris, France, Hopitaux universitaires Henri Mondor, AP-HP, Departement de biochimie-pharmacologie-biologie moleculaire-genetique medicale, Creteil, France.
+ Peoc'h, Katell. HUPNVS, UF de biochimie clinique, Hopitaux Beaujon et Bichat, AP-HP, France ; Universite Paris, UFR de medecine Xavier Bichat, Centre de recherche sur l'inflammation (CRI), Paris, France.
+MeSH Subject Headings
+ *Adiponectin/an [Analysis]
+ Biomarkers/an [Analysis]
+ Clinical Laboratory Services/st [Standards]
+ Clinical Laboratory Services/sn [Statistics & Numerical Data]
+ *Clinical Laboratory Services
+ France/ep [Epidemiology]
+ Humans
+ *Leptin/an [Analysis]
+ Lipodystrophy/bl [Blood]
+ Lipodystrophy/cl [Classification]
+ Lipodystrophy/di [Diagnosis]
+ Lipodystrophy/th [Therapy]
+ Monitoring, Physiologic/mt [Methods]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/th [Therapy]
+ Phenotype
+ *Practice Patterns, Physicians'/sn [Statistics & Numerical Data]
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Editorial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1684%2fabc.2020.1561
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bastard&issn=0003-3898&title=Annales+de+Biologie+Clinique&atitle=Leptine+et+adiponectine+%3A+deux+actes+RIHN%2C+quelle+place+en+pratique+%3F&volume=78&issue=3&spage=229&epage=230&date=2020&doi=10.1684%2Fabc.2020.1561&pmid=32540811&sid=OVID:medline
+
+<1288>
+Unique Identifier
+ 32530150
+Title
+ [Inflammation in kidney diseases]. [Review] [Italian]
+Source
+ Giornale Italiano di Nefrologia. 37(3), 2020 Jun 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nigro M; Viggiano D; D'Angio P; Guarino E; Capasso G; Gigliotti G
+Authors Full Name
+ Nigro, Michelangelo; Viggiano, Davide; D'Angio, Pierluigi; Guarino, Ermanno; Capasso, Giovambattista; Gigliotti, Giuseppe.
+Institution
+ Nigro, Michelangelo. UOC Nefrologia e dialisi, Ospedale Civile di Eboli "MM.SS. Addolorata", Eboli, Italy.
+ Viggiano, Davide. Dip. Medicina e Scienze della Salute, Univ. Molise, Campobasso, Italy; Dip. Scienze Mediche Traslazionali, Univ. della Campania "L.Vanvitelli", Napoli, Italy; BIOGEM, Ariano Irpino, Italy.
+ D'Angio, Pierluigi. UOC Nefrologia e dialisi, Ospedale Civile di Eboli "MM.SS. Addolorata", Eboli, Italy.
+ Guarino, Ermanno. UOC Nefrologia e dialisi, Ospedale Civile di Eboli "MM.SS. Addolorata", Eboli, Italy.
+ Capasso, Giovambattista. Dip. Scienze Mediche Traslazionali, Univ. della Campania "L.Vanvitelli", Napoli, Italy; BIOGEM, Ariano Irpino, Italy.
+ Gigliotti, Giuseppe. UOC Nefrologia e dialisi, Ospedale Civile di Eboli "MM.SS. Addolorata", Eboli, Italy.
+MeSH Subject Headings
+ Acute Disease
+ Adrenal Cortex Hormones/tu [Therapeutic Use]
+ Atherosclerosis/co [Complications]
+ Biomarkers/bl [Blood]
+ Chronic Disease
+ Diabetes Complications
+ History, 18th Century
+ History, 19th Century
+ History, Ancient
+ Humans
+ Immunosuppressive Agents/tu [Therapeutic Use]
+ Inflammation/bl [Blood]
+ Inflammation/cl [Classification]
+ Inflammation/dt [Drug Therapy]
+ Inflammation/pa [Pathology]
+ *Inflammation
+ Kidney Diseases/bl [Blood]
+ Kidney Diseases/cl [Classification]
+ Kidney Diseases/et [Etiology]
+ Kidney Diseases/pa [Pathology]
+ *Kidney Diseases
+ Obesity/co [Complications]
+ Terminology as Topic
+Keyword Heading
+ acute phase proteins
+ immune suppressors
+ inflammation
+ nephritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The term "inflammation" is certainly one of the oldest medical terms still in use. However, its meaning has changed over the centuries. This work gives a historical and critical review of the concept of inflammation, with special reference to kidney diseases. Over time the definition of inflammation has shifted from a pure collection of symptoms to a histopathological definition, characterized by the tissue "inflammatory infiltrates" and different subcategories according to the cell type involved. The advantages of this classification are the generally good response to corticosteroids (with only a few exceptions) and the availability of specific drugs for each inflammatory infiltrate. Finally, a "molecular" definition of inflammation has arisen, where the inflammatory infiltrates make room to a plethora of plasma mediators. The authors show that the use of plasma biomarkers as a tool to define inflammatory state leads to net inflation of the number of "inflammatory" diseases - an effect that shows clearly in the field of nephrology. Copyright by Societa Italiana di Nefrologia SIN, Rome, Italy.
+Registry Number/Name of Substance
+ 0 (Adrenal Cortex Hormones). 0 (Biomarkers). 0 (Immunosuppressive Agents).
+Publication Type
+ Historical Article. Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&AN=32530150
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nigro&issn=0393-5590&title=Giornale+Italiano+di+Nefrologia&atitle=%5BInflammation+in+kidney+diseases%5D.&volume=37&issue=3&spage=&epage=&date=2020&doi=&pmid=32530150&sid=OVID:medline
+
+<1289>
+Unique Identifier
+ 32529242
+Title
+ Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(8), 2020 08 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van der Heijden CDCC; Ter Horst R; van den Munckhof ICL; Schraa K; de Graaf J; Joosten LAB; Danser AHJ; Netea MG; Deinum J; Rutten J; Riksen NP
+Authors Full Name
+ van der Heijden, Charlotte D C C; Ter Horst, Rob; van den Munckhof, Inge C L; Schraa, Kiki; de Graaf, Jacqueline; Joosten, Leo A B; Danser, A H Jan; Netea, Mihai G; Deinum, Jaap; Rutten, Joost; Riksen, Niels P.
+Institution
+ van der Heijden, Charlotte D C C. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ van der Heijden, Charlotte D C C. Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Ter Horst, Rob. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Ter Horst, Rob. Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ van den Munckhof, Inge C L. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Schraa, Kiki. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ de Graaf, Jacqueline. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Joosten, Leo A B. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Joosten, Leo A B. Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Joosten, Leo A B. Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca Romania.
+ Danser, A H Jan. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, GD, the Netherlands.
+ Netea, Mihai G. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Netea, Mihai G. Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Netea, Mihai G. Department for Genomics & Immunoregulation, Life and Medical Sciences 12 Institute (LIMES), University of Bonn, Bonn, Germany.
+ Deinum, Jaap. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Rutten, Joost. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Riksen, Niels P. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+ Riksen, Niels P. Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, GA, the Netherlands.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ *Aldosterone/bl [Blood]
+ Aldosterone/im [Immunology]
+ Atherosclerosis/bl [Blood]
+ *Atherosclerosis/di [Diagnosis]
+ Atherosclerosis/et [Etiology]
+ Biomarkers/bl [Blood]
+ Carotid Arteries/dg [Diagnostic Imaging]
+ Cross-Sectional Studies
+ Fasting/bl [Blood]
+ Female
+ Humans
+ Hyperaldosteronism/co [Complications]
+ *Hyperaldosteronism/di [Diagnosis]
+ Hyperaldosteronism/im [Immunology]
+ Hyperaldosteronism/me [Metabolism]
+ Inflammation/bl [Blood]
+ *Inflammation/di [Diagnosis]
+ Inflammation/im [Immunology]
+ Inflammation/me [Metabolism]
+ Linoleic Acid/bl [Blood]
+ Linoleic Acid/me [Metabolism]
+ Lipoproteins, VLDL/bl [Blood]
+ Lipoproteins, VLDL/me [Metabolism]
+ Magnetic Resonance Imaging
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/im [Immunology]
+ Metabolic Syndrome/me [Metabolism]
+ Metabolomics
+ Middle Aged
+ Netherlands
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/im [Immunology]
+ Obesity/me [Metabolism]
+ Renin/bl [Blood]
+ Renin/im [Immunology]
+ Triglycerides/bl [Blood]
+ Triglycerides/me [Metabolism]
+Keyword Heading
+ aldosterone
+ atherosclerosis
+ inflammation
+ metabolomics
+ obesity
+ renin-angiotensin-aldosterone system
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Not all obese individuals develop cardiovascular disease (CVD). Hyperaldosteronism is suggested to cause inflammation and metabolic dysregulation, and might contribute to CVD development in obese individuals.
+
+ OBJECTIVE: We aimed to investigate the association of aldosterone concentrations with inflammation, metabolic disturbances, and atherosclerosis in overweight and obese individuals. Additionally, we measured renin concentrations to investigate whether the observed effects reflected general activation of the renin-angiotensin-aldosterone system (RAAS).
+
+ DESIGN: A cross-sectional cohort study (300-OB study) was conducted. Various inflammatory parameters, traits of the metabolic syndrome, lipidome and metabolome parameters, fat distribution, and carotid atherosclerosis were associated with plasma aldosterone and renin levels.
+
+ SETTING: The setting of this study was the Radboudumc (i.o. Radboudumc), the Netherlands.
+
+ PATIENTS: A total of 302 individuals with a body mass index greater than or equal to 27 kg/m2 participated.
+
+ MAIN OUTCOME MEASURES AND RESULTS: Aldosterone was associated with various markers of inflammation and metabolic dysregulation, which partly differed from the associations observed for renin. Although both were associated with inflammatory cell numbers, only renin was associated with classical markers of systemic inflammation. Both were associated with the metabolic syndrome and hepatic steatosis. Of the traits that constitute metabolic syndrome, aldosterone, but not renin, was associated with triglyceride concentrations. Accordingly, aldosterone was associated with large very low-density lipoprotein particles; metabolomics studies further associated aldosterone with urate concentrations and derivatives of the linoleic acid metabolism pathway. Neither aldosterone nor renin was associated with atherosclerotic plaque thickness.
+
+ CONCLUSIONS: Aldosterone is not an important driver of systemic inflammation in the obese, whereas aldosterone concentrations and metabolic dysregulation are strongly intertwined in these individuals. Although prospective studies are necessary to validate these results, the independent effects of aldosterone on carotid atherosclerosis appear modest. Copyright © Endocrine Society 2020.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipoproteins, VLDL). 0 (Triglycerides). 4964P6T9RB (Aldosterone). 9KJL21T0QJ (Linoleic Acid). EC 3-4-23-15 (Renin).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1210%2fclinem%2fdgaa356
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+der+Heijden&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Vasculometabolic+and+Inflammatory+Effects+of+Aldosterone+in+Obesity.&volume=105&issue=8&spage=2719&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgaa356&pmid=32529242&sid=OVID:medline
+
+<1290>
+Unique Identifier
+ 32528467
+Title
+ Obesity and Sex Affect the Immune Responses to Tick-Borne Encephalitis Booster Vaccination.
+Source
+ Frontiers in Immunology. 11:860, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Garner-Spitzer E; Poellabauer EM; Wagner A; Guzek A; Zwazl I; Seidl-Friedrich C; Binder CJ; Stiasny K; Kundi M; Wiedermann U
+Authors Full Name
+ Garner-Spitzer, Erika; Poellabauer, Eva-Maria; Wagner, Angelika; Guzek, Angela; Zwazl, Ines; Seidl-Friedrich, Claudia; Binder, Christoph J; Stiasny, Karin; Kundi, Michael; Wiedermann, Ursula.
+Institution
+ Garner-Spitzer, Erika. Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
+ Poellabauer, Eva-Maria. Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
+ Wagner, Angelika. Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
+ Guzek, Angela. Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
+ Zwazl, Ines. Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
+ Seidl-Friedrich, Claudia. Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
+ Binder, Christoph J. Department for Laboratory Medicine, Medical University Vienna, Vienna, Austria.
+ Stiasny, Karin. Center of Virology, Medical University Vienna, Vienna, Austria.
+ Kundi, Michael. Center for Public Health, Medical University Vienna, Vienna, Austria.
+ Wiedermann, Ursula. Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
+MeSH Subject Headings
+ Adult
+ Animals
+ Antibodies, Viral/bl [Blood]
+ Biomarkers/bl [Blood]
+ *Encephalitis Viruses, Tick-Borne/im [Immunology]
+ Encephalitis, Tick-Borne/im [Immunology]
+ *Encephalitis, Tick-Borne/pc [Prevention & Control]
+ Encephalitis, Tick-Borne/vi [Virology]
+ Female
+ Host-Pathogen Interactions
+ Humans
+ Immunity, Cellular
+ Immunity, Humoral
+ *Immunization, Secondary
+ *Immunogenicity, Vaccine
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/im [Immunology]
+ Sex Factors
+ *Ticks/vi [Virology]
+ Time Factors
+ Treatment Outcome
+ *Viral Vaccines/ad [Administration & Dosage]
+Keyword Heading
+ hormones
+ immune dysfunction
+ metabolism
+ obesity
+ sex
+ tick-borne encephalitis
+ vaccination
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity has dramatically increased over the last 30 years and reaches according to World Health Organization dimensions of a global epidemic. The obesity-associated chronic low-level inflammation contributes to severe comorbidities and directly affects many immune cells leading to immune dysfunction and increased susceptibility to infections. Thus, prophylaxis against vaccine-preventable diseases is crucial, yet the responsiveness to several vaccines is unclear under obesity. In order to assess the responsiveness to tick-borne encephalitis (TBE) vaccine, we revaccinated 37 obese individuals and 36 normal-weight controls with a licensed TBE vaccine. Metabolic, hormonal, and immunologic profiles along with vaccine-specific humoral and cellular immune responses were evaluated in sera and peripheral blood mononuclear cells (PBMCs) before, 1 week, 4 weeks, and 6 months after TBE booster. Obese adults had significantly increased metabolic (triglycerides, cholesterol ratios, leptin, insulin) and proinflammatory (C-reactive protein) parameters. They showed stronger initial increase of TBE-specific Ab titers (d7_d28) followed by a significantly faster decline after 6 months, which correlated with high body mass index and leptin and insulin levels. The fold increase of Ab-titer levels was significantly higher in obese compared to control males and linked to reduced testosterone levels. Obesity also affected cellular responses: PBMCs of the obese vaccinees had elevated interleukin 2 and interferon gamma levels upon antigen stimulation, indicating a leptin-dependent proinflammatory TH1 polarization. The expansion of total and naive B cells in obese might explain the initial increase of Ab titers, whereas the reduced B-memory cell and plasma blast generation could be related to fast Ab decline with a limited maintenance of titers. Among T follicular helper cell (Tfh) cells, the Tfh17 subset was significantly expanded particularly in obese males, where we observed a strong initial Ab increase. Systemic but not local vaccine side effects were more frequent in obese subjects as a possible consequence of their low-grade proinflammatory state. In summary, TBE booster vaccination was effective in obese individuals, yet the faster Ab decline could result in a reduced long-term protection. The sex-based differences in vaccine responses indicate a complex interplay of the endocrine, metabolic, and immune system during obesity. Further studies on the long-term protection after vaccination are ongoing, and also evaluation of primary vaccination against TBE in obese individuals is planned. Clinical Trial Registration: NCT04017052; https://clinicaltrials.gov/ct2/show/NCT04017052. Copyright © 2020 Garner-Spitzer, Poellabauer, Wagner, Guzek, Zwazl, Seidl-Friedrich, Binder, Stiasny, Kundi and Wiedermann.
+Registry Number/Name of Substance
+ 0 (Antibodies, Viral). 0 (Biomarkers). 0 (Viral Vaccines).
+Publication Type
+ Clinical Trial, Phase IV. Comparative Study. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffimmu.2020.00860
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Garner-Spitzer&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Obesity+and+Sex+Affect+the+Immune+Responses+to+Tick-Borne+Encephalitis+Booster+Vaccination.&volume=11&issue=&spage=860&epage=&date=2020&doi=10.3389%2Ffimmu.2020.00860&pmid=32528467&sid=OVID:medline
+
+<1291>
+Unique Identifier
+ 32525843
+Title
+ Platelet factor 4 is a biomarker for lymphatic-promoted disorders.
+Source
+ Jci Insight. 5(13), 2020 07 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ma W; Gil HJ; Escobedo N; Benito-Martin A; Ximenez-Embun P; Munoz J; Peinado H; Rockson SG; Oliver G
+Authors Full Name
+ Ma, Wanshu; Gil, Hyea Jin; Escobedo, Noelia; Benito-Martin, Alberto; Ximenez-Embun, Pilar; Munoz, Javier; Peinado, Hector; Rockson, Stanley G; Oliver, Guillermo.
+Institution
+ Ma, Wanshu. Center for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, Illinois, USA.
+ Gil, Hyea Jin. Center for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, Illinois, USA.
+ Escobedo, Noelia. Center for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, Illinois, USA.
+ Benito-Martin, Alberto. Children's Cancer & Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Weill Cornell Medicine, New York, USA.
+ Ximenez-Embun, Pilar. Proteomics Unit - ProteoRed-ISCIII, Spanish National Cancer Research Centre, Madrid, Spain.
+ Munoz, Javier. Proteomics Unit - ProteoRed-ISCIII, Spanish National Cancer Research Centre, Madrid, Spain.
+ Peinado, Hector. Microenvironment & Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Center, Madrid, Spain.
+ Rockson, Stanley G. Division of Cardiovascular Medicine, Center for Lymphatic and Venous Disorders, Stanford University School of Medicine, Stanford, California, USA.
+ Oliver, Guillermo. Center for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, Illinois, USA.
+MeSH Subject Headings
+ Adipose Tissue/pa [Pathology]
+ Animals
+ *Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ Exosomes/me [Metabolism]
+ Lipedema/di [Diagnosis]
+ *Lipedema/me [Metabolism]
+ Lipedema/pp [Physiopathology]
+ *Lymphedema/me [Metabolism]
+ Lymphedema/pp [Physiopathology]
+ Mice
+ Obesity/pa [Pathology]
+ *Platelet Factor 4/me [Metabolism]
+ Subcutaneous Fat/pa [Pathology]
+Keyword Heading
+ Diagnostics
+ Vascular Biology
+ endothelial cells
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Genetic or acquired defects of the lymphatic vasculature often result in disfiguring, disabling, and, occasionally, life-threatening clinical consequences. Advanced forms of lymphedema are readily diagnosed clinically, but more subtle presentations often require invasive imaging or other technologies for a conclusive diagnosis. On the other hand, lipedema, a chronic lymphatic microvascular disease with pathological accumulation of subcutaneous adipose tissue, is often misdiagnosed as obesity or lymphedema; currently there are no biomarkers or imaging criteria available for a conclusive diagnosis. Recent evidence suggests that otherwise-asymptomatic defective lymphatic vasculature likely contributes to an array of other pathologies, including obesity, inflammatory bowel disease, and neurological disorders. Accordingly, identification of biomarkers of lymphatic malfunction will provide a valuable resource for the diagnosis and clinical differentiation of lymphedema, lipedema, obesity, and other potential lymphatic pathologies. In this paper, we profiled and compared blood plasma exosomes isolated from mouse models and from human subjects with and without symptomatic lymphatic pathologies. We identified platelet factor 4 (PF4/CXCL4) as a biomarker that could be used to diagnose lymphatic vasculature dysfunction. Furthermore, we determined that PF4 levels in circulating blood plasma exosomes were also elevated in patients with lipedema, supporting current claims arguing that at least some of the underlying attributes of this disease are also the consequence of lymphatic defects.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 37270-94-3 (Platelet Factor 4).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1172%2fjci.insight.135109
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ma&issn=2379-3708&title=Jci+Insight&atitle=Platelet+factor+4+is+a+biomarker+for+lymphatic-promoted+disorders.&volume=5&issue=13&spage=&epage=&date=2020&doi=10.1172%2Fjci.insight.135109&pmid=32525843&sid=OVID:medline
+
+<1292>
+Unique Identifier
+ 32523012
+Title
+ Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study.
+Source
+ Scientific Reports. 10(1):9422, 2020 06 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chia AR; de Seymour JV; Wong G; Sulek K; Han TL; McKenzie EJ; Aris IM; Godfrey KM; Yap F; Tan KH; Shek LP; Lee YS; Kramer MS; Karnani N; Chong MF; Baker PN
+Authors Full Name
+ Chia, Ai-Ru; de Seymour, Jamie V; Wong, Gerard; Sulek, Karolina; Han, Ting-Li; McKenzie, Elizabeth J; Aris, Izzuddin M; Godfrey, Keith M; Yap, Fabian; Tan, Kok Hian; Shek, Lynette Pei-Chi; Lee, Yung Seng; Kramer, Michael S; Karnani, Neerja; Chong, Mary Foong-Fong; Baker, Philip N.
+Institution
+ Chia, Ai-Ru. Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. airu-chia@nus.edu.sg.
+ Chia, Ai-Ru. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. airu-chia@nus.edu.sg.
+ de Seymour, Jamie V. School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand.
+ Wong, Gerard. Singapore Institute for Clinical Science, Agency for Science, Technology, and Research, Singapore, Singapore.
+ Sulek, Karolina. Liggins Institute, University of Auckland, Auckland, New Zealand.
+ Sulek, Karolina. Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Han, Ting-Li. Liggins Institute, University of Auckland, Auckland, New Zealand.
+ Han, Ting-Li. First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
+ McKenzie, Elizabeth J. Liggins Institute, University of Auckland, Auckland, New Zealand.
+ Aris, Izzuddin M. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
+ Godfrey, Keith M. Medical Research Council Lifecourse Epidemiology Unit and National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
+ Yap, Fabian. Duke-NUS Medical School, Singapore, Nanyang Technological University, Singapore, Singapore.
+ Yap, Fabian. Department of Pediatrics, KK Women's and Children's Hospital, Singapore, Singapore.
+ Yap, Fabian. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
+ Tan, Kok Hian. Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
+ Shek, Lynette Pei-Chi. Singapore Institute for Clinical Science, Agency for Science, Technology, and Research, Singapore, Singapore.
+ Shek, Lynette Pei-Chi. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
+ Lee, Yung Seng. Singapore Institute for Clinical Science, Agency for Science, Technology, and Research, Singapore, Singapore.
+ Lee, Yung Seng. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
+ Lee, Yung Seng. Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.
+ Kramer, Michael S. Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
+ Kramer, Michael S. Departments of Pediatrics and of Epidemiology, Biostatistics and Occupational Health, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
+ Karnani, Neerja. Singapore Institute for Clinical Science, Agency for Science, Technology, and Research, Singapore, Singapore.
+ Chong, Mary Foong-Fong. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. mary_chong@nus.edu.sg.
+ Chong, Mary Foong-Fong. Singapore Institute for Clinical Science, Agency for Science, Technology, and Research, Singapore, Singapore. mary_chong@nus.edu.sg.
+ Baker, Philip N. Liggins Institute, University of Auckland, Auckland, New Zealand.
+ Baker, Philip N. First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
+ Baker, Philip N. College of Life Sciences, University of Leicester, Leicester, UK.
+MeSH Subject Headings
+ *Adiposity/ph [Physiology]
+ Adult
+ *Biomarkers/bl [Blood]
+ Birth Weight/ph [Physiology]
+ Body Mass Index
+ Diet/mt [Methods]
+ Female
+ Gestational Age
+ Humans
+ Infant, Newborn
+ *Maternal Nutritional Physiological Phenomena/ph [Physiology]
+ Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ Pregnancy
+ Prospective Studies
+ Skinfold Thickness
+Abstract
+ Infant adiposity may be related to later metabolic health. Maternal metabolite profiling reflects both genetic and environmental influences and allows elucidation of metabolic pathways associated with infant adiposity. In this multi-ethnic Asian cohort, we aimed to (i) identify maternal plasma metabolites associated with infant adiposity and other birth outcomes and (ii) investigate the maternal characteristics associated with those metabolites. In 940 mother-offspring pairs, we performed gas chromatography-mass spectrometry and identified 134 metabolites in maternal fasting plasma at 26-28 weeks of gestation. At birth, neonatal triceps and subscapular skinfold thicknesses were measured by trained research personnel, while weight and length measures were abstracted from delivery records. Gestational age was estimated from first-trimester dating ultrasound. Associations were assessed by multivariable linear regression, with p-values corrected using the Benjamini-Hochberg approach. At a false discovery rate of 5%, we observed associations between 28 metabolites and neonatal sum of skinfold thicknesses (13 amino acid-related, 4 non-esterified fatty acids, 6 xenobiotics, and 5 unknown compounds). Few associations were observed with gestational duration, birth weight, or birth length. Maternal ethnicity, pre-pregnancy BMI, and diet quality during pregnancy had the strongest associations with the specific metabolome related to infant adiposity. Further studies are warranted to replicate our findings and to understand the underlying mechanisms.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-66026-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chia&issn=2045-2322&title=Scientific+Reports&atitle=Maternal+plasma+metabolic+markers+of+neonatal+adiposity+and+associated+maternal+characteristics%3A+The+GUSTO+study.&volume=10&issue=1&spage=9422&epage=&date=2020&doi=10.1038%2Fs41598-020-66026-5&pmid=32523012&sid=OVID:medline
+
+<1293>
+Unique Identifier
+ 32521782
+Title
+ Effect of Morning vs. Evening Turmeric Consumption on Urine Oxidative Stress Biomarkers in Obese, Middle-Aged Adults: A Feasibility Study.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 17(11), 2020 06 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Blanton C; Gordon B
+Authors Full Name
+ Blanton, Cynthia; Gordon, Barbara.
+Institution
+ Blanton, Cynthia. Department of Nutrition and Dietetics, Idaho State University, Pocatello, ID 83209, USA.
+ Gordon, Barbara. Department of Nutrition and Dietetics, Idaho State University, Pocatello, ID 83209, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/ur [Urine]
+ Circadian Rhythm
+ *Curcuma
+ Feasibility Studies
+ Humans
+ Middle Aged
+ *Obesity
+ *Oxidative Stress/ph [Physiology]
+Keyword Heading
+ circadian
+ inflammation
+ oxidative stress
+ turmeric
+ urine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The circadian rhythm of biological systems is an important consideration in developing health interventions. The immune and oxidative defense systems exhibit circadian periodicity, with an anticipatory increase in activity coincident with the onset of the active period. Spice consumption is associated with enhanced oxidative defense. The objective of this study was to test the feasibility of a protocol, comparing the effects of morning vs. evening consumption of turmeric on urine markers of oxidative stress in obese, middle-aged adults. Using a within-sample design, participants received each of four clock time x treatment administrations, each separated by one week: morning turmeric; evening turmeric; morning control; evening control. Participants prepared for each lab visit by consuming a low-antioxidant diet for two days and fasting for 12 h. Urine was collected in the lab at baseline and one-hour post-meal and at home for the following five hours. The results showed that the processes were successful in executing the protocol and collecting the measurements and that participants understood and adhered to the instructions. The findings also revealed that the spice treatment did not elicit the expected antioxidant effect and that the six-hour post-treatment urine collection period did not detect differences in urine endpoints across treatments. This feasibility study revealed that modifications to the spice treatment and urine sampling timeline are needed before implementing a larger study.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijerph17114088
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Blanton&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Effect+of+Morning+vs.+Evening+Turmeric+Consumption+on+Urine+Oxidative+Stress+Biomarkers+in+Obese%2C+Middle-Aged+Adults%3A+A+Feasibility+Study.&volume=17&issue=11&spage=&epage=&date=2020&doi=10.3390%2Fijerph17114088&pmid=32521782&sid=OVID:medline
+
+<1294>
+Unique Identifier
+ 32520693
+Title
+ Effects of a Low Carb Diet and Whey Proteins on Anthropometric, Hematochemical, and Cardiovascular Parameters in Subjects with Obesity.
+Source
+ Endocrine, Metabolic & Immune Disorders Drug Targets. 20(10):1719-1725, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ De Pergola G; Zupo R; Lampignano L; Paradiso S; Murro I; Cecere A; Bartolomeo N; Ciccone MM; Giannelli G; Triggiani V
+Authors Full Name
+ De Pergola, Giovanni; Zupo, Roberta; Lampignano, Luisa; Paradiso, Silvia; Murro, Isanna; Cecere, Annagrazia; Bartolomeo, Nicola; Ciccone, Marco M; Giannelli, Gianluigi; Triggiani, Vincenzo.
+Institution
+ De Pergola, Giovanni. Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
+ Zupo, Roberta. National Institute of Gastroenterology "S. de Bellis", Research Hospital, Castellana Grotte, Italy.
+ Lampignano, Luisa. National Institute of Gastroenterology "S. de Bellis", Research Hospital, Castellana Grotte, Italy.
+ Paradiso, Silvia. Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
+ Murro, Isanna. Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
+ Cecere, Annagrazia. Section of Cardiovascular Disease, Department of Organ Transplantation, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
+ Bartolomeo, Nicola. Medical Statistics, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
+ Ciccone, Marco M. Section of Cardiovascular Disease, Department of Organ Transplantation, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
+ Giannelli, Gianluigi. Scientific Direction, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, 70013 Bari, Italy.
+ Triggiani, Vincenzo. Section of Endocrinology and Metabolic Diseases, Department of Emergency and Organ Transplantation University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Blood Pressure
+ Cardiovascular System/dg [Diagnostic Imaging]
+ *Cardiovascular System/pp [Physiopathology]
+ Carotid Intima-Media Thickness
+ *Diet, Carbohydrate-Restricted
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Time Factors
+ Treatment Outcome
+ Vasodilation
+ *Weight Loss
+ *Whey Proteins/ad [Administration & Dosage]
+Keyword Heading
+ Low carbohydrate diet
+ endothelium
+ intima-media thickness
+ obesity
+ overweight
+ whey proteins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The best way to lose body weight, without using drugs and/or suffering hunger and stress, has not yet been defined. The present study tested a low carbohydrate diet, enriched with proteins, in subjects with overweight and obesity.
+
+ METHODS: The study enrolled 22 uncomplicated overweight and obese subjects. Several parameters were examined before and after 6 weeks of a low-carbohydrate diet, enriched with 18 g of whey proteins. Anthropometric (body mass index, waist circumference) variables, fasting hormones (insulin, TSH, FT3, FT4), and metabolic (glucose, prealbumin, and lipid levels) parameters were measured. 25- OH-vitamin D (25 (OH) D), parathyroid hormone (PTH) and osteocalcin, were also quantified. Body composition parameters (fat mass, fat-free mass, body cell mass, total body water) were measured by electrical bioimpedance analysis. As cardiovascular parameters, blood pressure, endothelium flowmediated dilation (FMD), and common carotid artery intima-media thickness were also measured.
+
+ RESULTS: The low-carbohydrate diet integrated with proteins induced a significant decrease in body weight (P < 0.001), waist circumference (P < 0.001), fat mass (P < 0.001), diastolic blood pressure (P < 0.01), triglycerides (P < 0.001), total cholesterol (P < 0.001), pre-albumin (P < 0.001), insulin (P < 0.001), HOMAIR (P < 0.001), FT3 (P < 0.05), and c-IMT (P < 0.001), and a significant increase in FMD (P < 0.001) and 25 (OH) D (P < 0.001) was also observed.
+
+ CONCLUSION: All these results suggest that a short-term non-prescriptive low carbohydrate diet, enriched with whey proteins, may be a good way to start losing fat mass and increase health. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Whey Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2174%2f1871530320666200610143724
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=De+Pergola&issn=1871-5303&title=Endocrine%2C+Metabolic+%26+Immune+Disorders+Drug+Targets&atitle=Effects+of+a+Low+Carb+Diet+and+Whey+Proteins+on+Anthropometric%2C+Hematochemical%2C+and+Cardiovascular+Parameters+in+Subjects+with+Obesity.&volume=20&issue=10&spage=1719&epage=1725&date=2020&doi=10.2174%2F1871530320666200610143724&pmid=32520693&sid=OVID:medline
+
+<1295>
+Unique Identifier
+ 32517059
+Title
+ Sodium Glucose Co-Transporter 2 Inhibitor Ameliorates Autophagic Flux Impairment on Renal Proximal Tubular Cells in Obesity Mice.
+Source
+ International Journal of Molecular Sciences. 21(11), 2020 Jun 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fukushima K; Kitamura S; Tsuji K; Sang Y; Wada J
+Author NameID
+ Kitamura, Shinji; ORCID: https://orcid.org/0000-0003-4535-8092
+Authors Full Name
+ Fukushima, Kazuhiko; Kitamura, Shinji; Tsuji, Kenji; Sang, Yizhen; Wada, Jun.
+Institution
+ Fukushima, Kazuhiko. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho, Okayama-shi, Okayama 700-8558, Japan.
+ Kitamura, Shinji. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho, Okayama-shi, Okayama 700-8558, Japan.
+ Tsuji, Kenji. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho, Okayama-shi, Okayama 700-8558, Japan.
+ Sang, Yizhen. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho, Okayama-shi, Okayama 700-8558, Japan.
+ Wada, Jun. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho, Okayama-shi, Okayama 700-8558, Japan.
+MeSH Subject Headings
+ Animals
+ Autophagosomes/me [Metabolism]
+ *Autophagy/de [Drug Effects]
+ Autophagy/ge [Genetics]
+ Biomarkers
+ *Epithelial Cells/de [Drug Effects]
+ *Epithelial Cells/me [Metabolism]
+ Immunohistochemistry
+ *Kidney Tubules, Proximal/me [Metabolism]
+ Lipid Metabolism/de [Drug Effects]
+ Lysosomes/me [Metabolism]
+ Mice
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Sodium-Glucose Transporter 2/me [Metabolism]
+ *Sodium-Glucose Transporter 2 Inhibitors/pd [Pharmacology]
+ TOR Serine-Threonine Kinases/me [Metabolism]
+Keyword Heading
+ autophagy
+ mammalian target of rapamycin (mTOR)
+ multi lamellar body
+ obesity
+ sodium glucose co-transporter 2 inhibitor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is supposed to cause renal injury via autophagy deficiency. Recently, sodium glucose co-transporter 2 inhibitors (SGLT2i) were reported to protect renal injury. However, the mechanisms of SGLT2i for renal protection are unclear. Here, we investigated the effect of SGLT2i for autophagy in renal proximal tubular cells (PTCs) on obesity mice. We fed C57BL/6J mice with a normal diet (ND) or high-fat and -sugar diet (HFSD) for nine weeks, then administered SGLT2i, empagliflozin, or control compound for one week. Each group contained N = 5. The urinary N-acetyl-beta-d-glucosaminidase level in the HFSD group significantly increased compared to ND group. The tubular damage was suppressed in the SGLT2i-HFSD group. In electron microscopic analysis, multi lamellar bodies that increased in autophagy deficiency were increased in PTCs in the HFSD group but significantly suppressed in the SGLT2i group. The autophagosomes of damaged mitochondria in PTCs in the HFSD group frequently appeared in the SGLT2i group. p62 accumulations in PTCs were significantly increased in HFSD group but significantly suppressed by SGLT2i. In addition, the mammalian target of rapamycin was activated in the HFSD group but significantly suppressed in SGLT2i group. These data suggest that SGLT2i has renal protective effects against obesity via improving autophagy flux impairment in PTCs on a HFSD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Sodium-Glucose Transporter 2). 0 (Sodium-Glucose Transporter 2 Inhibitors). EC 2-7-11-1 (TOR Serine-Threonine Kinases).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijms21114054
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fukushima&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Sodium+Glucose+Co-Transporter+2+Inhibitor+Ameliorates+Autophagic+Flux+Impairment+on+Renal+Proximal+Tubular+Cells+in+Obesity+Mice.&volume=21&issue=11&spage=4054&epage=&date=2020&doi=10.3390%2Fijms21114054&pmid=32517059&sid=OVID:medline
+
+<1296>
+Unique Identifier
+ 32515572
+Title
+ Obesity, vitamin D status and physical activity: 1,25(OH)2D as a potential marker of vitamin D deficiency in obese subjects.
+Source
+ Panminerva Medica. 62(2):83-92, 2020 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Valentini A; Perrone MA; Cianfarani MA; Tarantino U; Massoud R; Merra G; Bernardini S; Morris HA; Bertoli A
+Authors Full Name
+ Valentini, Alessia; Perrone, Marco A; Cianfarani, Maria A; Tarantino, Umberto; Massoud, Renato; Merra, Giuseppe; Bernardini, Sergio; Morris, Howard A; Bertoli, Aldo.
+Institution
+ Valentini, Alessia. Department of Systems Medicine, Tor Vergata University, Rome, Italy.
+ Perrone, Marco A. Division of Cardiology, Tor Vergata University, Rome, Italy - marco.perrone01@gmail.com.
+ Perrone, Marco A. University Sports Center, Tor Vergata University, Rome, Italy.
+ Cianfarani, Maria A. Department of Systems Medicine, Tor Vergata University, Rome, Italy.
+ Tarantino, Umberto. Department of Orthopedics and Traumatology, Tor Vergata University, Rome, Italy.
+ Massoud, Renato. Department of Experimental Medicine, Tor Vergata University, Rome, Italy.
+ Merra, Giuseppe. Department of Experimental Medicine, Tor Vergata University, Rome, Italy.
+ Bernardini, Sergio. University Sports Center, Tor Vergata University, Rome, Italy.
+ Bernardini, Sergio. Department of Experimental Medicine, Tor Vergata University, Rome, Italy.
+ Morris, Howard A. School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
+ Bertoli, Aldo. Department of Systems Medicine, Tor Vergata University, Rome, Italy.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Bone Density
+ *Exercise
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ *Osteoporotic Fractures/bl [Blood]
+ Osteoporotic Fractures/di [Diagnosis]
+ Osteoporotic Fractures/ep [Epidemiology]
+ Osteoporotic Fractures/pp [Physiopathology]
+ Prevalence
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ Rome/ep [Epidemiology]
+ *Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ *Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/di [Diagnosis]
+ Vitamin D Deficiency/ep [Epidemiology]
+ Vitamin D Deficiency/pp [Physiopathology]
+Abstract
+ BACKGROUND: Obesity has been regarded to be protective against fracture in spite of its association with low levels of vitamin D. Vitamin D is the key regulator of bone metabolism and its deficiency contributes to higher level of parathyroid hormone (PTH), leading to the activation of bone turnover.
+
+ METHODS: We studied 161 subjects of which 65 were young healthy subjects and 96 were elderly subjects. We measured creatinine, 25(OH)D, 1,25(OH)2D, PTH, albumin, and calcium plasma levels, we evaluated physical activity, and we calculated BMI. A sub-cohort of elderly subjects also underwent DXA scans.
+
+ RESULTS: Overweight and obese subjects, as well as underweight ones, had lower levels of vitamin D but normal serum concentrations of 1,25(OH)2D and PTH was higher in underweight and obese subjects. Moreover, we found a nonlinear relationship between body mass index (BMI) and PTH with a significant U-shaped exponential regression. Regardless of BMI, 25(OH)D mean levels were higher in subjects who practice physical activity.
+
+ CONCLUSIONS: These findings suggest that physical activity and BMI had a significant effect on the metabolism of bone and vitamin D, but the effect of BMI was different in underweight, normal weight or obese subjects. In obesity the real vitamin D deficiency could be estimate by serum 1,25(OH)2D concentrations whose lower levels contribute to the higher PTH production and consequently to bone loss and to a greater fracture risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1406-16-2 (Vitamin D). 66772-14-3 (1,25-dihydroxyvitamin D).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.23736%2fS0031-0808.20.03770-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Valentini&issn=0031-0808&title=Panminerva+Medica&atitle=Obesity%2C+vitamin+D+status+and+physical+activity%3A+1%2C25%28OH%292D+as+a+potential+marker+of+vitamin+D+deficiency+in+obese+subjects.&volume=62&issue=2&spage=83&epage=92&date=2020&doi=10.23736%2FS0031-0808.20.03770-2&pmid=32515572&sid=OVID:medline
+
+<1297>
+Unique Identifier
+ 32515571
+Title
+ The impact of obesity on disease activity, damage accrual, inflammation markers and cardiovascular risk factors in systemic lupus erythematosus.
+Source
+ Panminerva Medica. 62(2):75-82, 2020 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Correa-Rodriguez M; Pocovi-Gerardino G; Callejas Rubio JL; Rios Fernandez R; Martin Amada M; Cruz Caparros M; Ortego-Centeno N; Rueda-Medina B
+Authors Full Name
+ Correa-Rodriguez, Maria; Pocovi-Gerardino, Gabriela; Callejas Rubio, Jose-Luis; Rios Fernandez, Raquel; Martin Amada, Maria; Cruz Caparros, Maria; Ortego-Centeno, Norberto; Rueda-Medina, Blanca.
+Institution
+ Correa-Rodriguez, Maria. Institute of Biomedical Research (IBS), Granada, Spain.
+ Correa-Rodriguez, Maria. Nursing Department, Faculty of Health Sciences, University of Granada, Granada, Spain.
+ Pocovi-Gerardino, Gabriela. Institute of Biomedical Research (IBS), Granada, Spain - gpocovi@correo.ugr.es.
+ Pocovi-Gerardino, Gabriela. Faculty of Health Sciences, University of Granada, Granada, Spain.
+ Callejas Rubio, Jose-Luis. Institute of Biomedical Research (IBS), Granada, Spain.
+ Callejas Rubio, Jose-Luis. Systemic Autoimmune Diseases Unit, San Cecilio University Hospital, Granada, Spain.
+ Rios Fernandez, Raquel. Institute of Biomedical Research (IBS), Granada, Spain.
+ Rios Fernandez, Raquel. Systemic Autoimmune Diseases Unit, San Cecilio University Hospital, Granada, Spain.
+ Martin Amada, Maria. Systemic Autoimmune Diseases Unit, Hospital of Jaen, Jaen, Spain.
+ Cruz Caparros, Maria. Systemic Autoimmune Diseases Unit, Hospital de Poniente, El Ejido, Spain.
+ Ortego-Centeno, Norberto. Institute of Biomedical Research (IBS), Granada, Spain.
+ Ortego-Centeno, Norberto. Systemic Autoimmune Diseases Unit, San Cecilio University Hospital, Granada, Spain.
+ Rueda-Medina, Blanca. Institute of Biomedical Research (IBS), Granada, Spain.
+ Rueda-Medina, Blanca. Nursing Department, Faculty of Health Sciences, University of Granada, Granada, Spain.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Pressure
+ Body Mass Index
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pp [Physiopathology]
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ Heart Disease Risk Factors
+ Humans
+ *Inflammation Mediators/bl [Blood]
+ Lupus Erythematosus, Systemic/bl [Blood]
+ *Lupus Erythematosus, Systemic/co [Complications]
+ Lupus Erythematosus, Systemic/di [Diagnosis]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ Risk Assessment
+ Severity of Illness Index
+ Spain
+ Vascular Stiffness
+ Waist-Height Ratio
+Abstract
+ BACKGROUND: We aimed to evaluate the relationships between obesity metrics including Body Mass Index (BMI), waist to height ratio (WtHR) and fat mass percentage, and disease activity, damage accrual, inflammation markers and traditional cardiovascular risk factors in SLE patients.
+
+ METHODS: A cross-sectional study was conducted on a sample of 275 patients (90.5% females; mean age 46.37+/-13.85 years). Disease activity was assessed with the SLE disease activity index (SLEDAI-2K), and disease-related organ damage was assessed using the SLICC/ACR damage index (SDI). Biochemical variables of lipids profile, high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), anti-dsDNA titers and complement components C3 and C4 serum levels were measured. Blood pressure and ankle-brachial index (ABI) were also calculated.
+
+ RESULTS: Significant differences were observed between normal-weight, overweight and obese patients in SLEDAI (2.60+/-2.48 vs. 2.71+/-2.65 vs. 3.84+/-3.02; P=0.004), SDI (0.76+/-1.10 vs. 1.09+/-1.24 vs. 1.57+/-1.54; P=0.002), hsCRP (2.15+/-2.93 vs. 3.24+/-3.63 vs. 5.30+/-5.63 mg/dL; P<0.001), complement C3 level (99.92+/-24.45 vs. 111.38+/-27.41 vs. 123.16+/-28.96 mg/dL; P<0.001), triglycerides serum levels (85.99+/-41.68 vs. 102.35+/-50.88 vs. 129.12+/-61.59 mg/dL; P<0.001) and systolic blood pressure (112.28+/-16.35 vs. 124.25+/-17.94 vs. 132.78+/-16.71 mmHg; P=0.001) after adjusting for age and sex.
+
+ CONCLUSIONS: Patients with SLE who are obese have worse disease activity and damage accrual, higher levels of inflammation markers hs-CRP and C3 complement, increased triglycerides serum levels and systolic blood pressure levels in comparison with overweight or normal weight SLE patients, supporting that optimizing weight in SLE patients should be a potential target to improve SLE outcomes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators).
+Publication Type
+ Comparative Study. Journal Article. Multicenter Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.23736%2fS0031-0808.19.03748-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Correa-Rodriguez&issn=0031-0808&title=Panminerva+Medica&atitle=The+impact+of+obesity+on+disease+activity%2C+damage+accrual%2C+inflammation+markers+and+cardiovascular+risk+factors+in+systemic+lupus+erythematosus.&volume=62&issue=2&spage=75&epage=82&date=2020&doi=10.23736%2FS0031-0808.19.03748-0&pmid=32515571&sid=OVID:medline
+
+<1298>
+Unique Identifier
+ 32513042
+Title
+ Association Between Cardiovascular Risk Factors and 25(OH)D Levels in Obese Patients.
+Source
+ Metabolic Syndrome & Related Disorders. 18(7):328-332, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Curvello-Silva KL; Oliveira NA; Silva TSS; Sousa CD; Daltro C
+Authors Full Name
+ Curvello-Silva, Karine L; Oliveira, Nataly A; Silva, Thalane S S; Sousa, Claudia D; Daltro, Carla.
+Institution
+ Curvello-Silva, Karine L. Nutrition School, Federal University of Bahia, Salvador, Brazil.
+ Oliveira, Nataly A. Nutrition School, Federal University of Bahia, Salvador, Brazil.
+ Silva, Thalane S S. Nutrition School, Federal University of Bahia, Salvador, Brazil.
+ Silva, Thalane S S. Nutrition Bachelor's Course, School of Technology and Science, Jequie, Bahia, Brazil.
+ Sousa, Claudia D. Nutrition Department, Nucleo de Tratamento e Cirurgia da Obesidade, Salvador, Brazil.
+ Daltro, Carla. Nutrition School, Federal University of Bahia, Salvador, Brazil.
+ Daltro, Carla. Nutrition Department, Nucleo de Tratamento e Cirurgia da Obesidade, Salvador, Brazil.
+ Daltro, Carla. Medicine School, Federal University of Bahia, Salvador, Brazil.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Cardiometabolic Risk Factors
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/et [Etiology]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/di [Diagnosis]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Prognosis
+ Risk Assessment
+ *Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ *Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/co [Complications]
+ Vitamin D Deficiency/di [Diagnosis]
+Keyword Heading
+ cardiovascular risk factors
+ lipid profile
+ metabolic syndrome
+ obesity
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Obesity is associated with lower levels of 25-hydroxyvitamin D [25(OH)D] and higher cardiovascular risk related to metabolic syndrome (MetS). Our purpose was to investigate if there is an association between levels of 25(OH)D and the components of MetS in an obese sample. Methods: This cross-sectional study enrolled obese patients referred for bariatric surgery in a specialized clinic. Secondary data were gathered as follows: glycemic and lipid profiles, 25(OH)D, anthropometric parameters, and clinical and sociodemographic information. The results were presented as means (standard deviations) or medians and interquartile intervals or absolute and relative frequencies. The patients were divided into three groups based on 25(OH)D terciles for analysis and were compared using ANOVA, Kruskal-Wallis or chi-squared tests. The correlations were calculated by Spearman's or Pearson's correlation tests. Results: We studied 299 patients, with the majority being women (74.9%). The patients' average (SD) age and 25(OH)D level were 36 (9) years and 25.8 (7.5) ng/mL, respectively. There was no association between vitamin D and MetS or its components. A progressive decrease in total cholesterol, low-density lipoprotein cholesterol (LDL-c), and nonhigh-density lipoprotein cholesterol (HDL-c) was observed as the serum vitamin D level increased, although only the latter reached statistical significance (P = 0.033). The correlation analysis showed a negative linear association between 25(OH)D and total cholesterol (r = -0.157; P = 0.047), 25(OH)D and LDL-c (r = -0.164; P = 0.038), and 25(OH)D and non-HDL-c (r = -0.176; P = 0.026). Conclusions: There was a negative correlation between 25(OH)D levels and the atherogenic profile but none with the MetS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 1406-16-2 (Vitamin D). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1089%2fmet.2020.0023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Curvello-Silva&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Association+Between+Cardiovascular+Risk+Factors+and+25%28OH%29D+Levels+in+Obese+Patients.&volume=18&issue=7&spage=328&epage=332&date=2020&doi=10.1089%2Fmet.2020.0023&pmid=32513042&sid=OVID:medline
+
+<1299>
+Unique Identifier
+ 32512872
+Title
+ Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 17(11), 2020 06 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sharma DK; Anderson PH; Morris HA; Clifton PM
+Author NameID
+ Sharma, Deepti K; ORCID: https://orcid.org/0000-0003-3651-3097
+ Clifton, Peter M; ORCID: https://orcid.org/0000-0002-6411-626X
+Authors Full Name
+ Sharma, Deepti K; Anderson, Paul H; Morris, Howard A; Clifton, Peter M.
+Institution
+ Sharma, Deepti K. Clinical and Health Sciences Academic Unit, University of South Australia, Adelaide 5001, Australia.
+ Anderson, Paul H. Clinical and Health Sciences Academic Unit, University of South Australia, Adelaide 5001, Australia.
+ Morris, Howard A. Clinical and Health Sciences Academic Unit, University of South Australia, Adelaide 5001, Australia.
+ Clifton, Peter M. Clinical and Health Sciences Academic Unit, University of South Australia, Adelaide 5001, Australia.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Aged
+ Biomarkers
+ *Bone Density
+ Female
+ Humans
+ *Intra-Abdominal Fat
+ Middle Aged
+ *Obesity
+ *Osteoporosis, Postmenopausal
+ *Postmenopause
+ Vitamin D
+Keyword Heading
+ CTX-1
+ bone turnover
+ obesity
+ parathyroid hormone
+ postmenopausal women
+ visceral fat
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The protective effect of obesity on bone health has been challenged by studies that link visceral adiposity to poor bone microarchitecture in young obese men and women. In postmenopausal women, the role of visceral adipose tissue (VAT) on bone turnover markers (BTMs) has not been investigated. The aim was to investigate the impact of VAT on BTMs, total bone mineral density (BMD), vitamin D metabolites and parathyroid levels (1-84 PTH) levels in postmenopausal women. A total of 76 lean and overweight women (without osteoporosis) underwent VAT measurements by dual-energy X-ray absorptiometry (iDXA). Blood samples were analyzed for serum C-terminal telopeptide of type 1 collagen (CTX-1), osteocalcin, bone-specific alkaline phosphatase (bone ALP), 1-84 PTH and vitamin D (25 hydroxyvitamin D, 25(OH)D) levels. VAT volumes ranged from 91 to 3392 cm3 and body mass index (BMI) ranged from 18.3 to 53.9 kg/m2. Women in the highest VAT quartile had significantly lower CTX-1, 25(OH)D, osteocalcin and the highest BMD (p < 0.05, for all). While VAT positively associated with BMD, after controlling for BMI, VAT was a negative predictor of BMD (beta = 0.368, p < 0.05). VAT was an independent negative predictor of CTX-1 (beta = -0.263, p < 0.05) and osteocalcin levels (beta = -0.277, p < 0.05). Among all measures of adiposity, VAT was the strongest independent determinant of BMD and BTMs. In clinical settings, VAT, and not BMI, may be a sensitive predictor of bone health in obese women.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fijerph17113996
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sharma&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Visceral+Fat+Is+a+Negative+Determinant+of+Bone+Health+in+Obese+Postmenopausal+Women.&volume=17&issue=11&spage=&epage=&date=2020&doi=10.3390%2Fijerph17113996&pmid=32512872&sid=OVID:medline
+
+<1300>
+Unique Identifier
+ 32512158
+Title
+ Association analysis of polymorphisms in LEP (rs7799039 and rs2167270) and LEPR (rs1137101) gene towards the development of type 2 diabetes in North Indian Punjabi population.
+Source
+ Gene. 754:144846, 2020 Sep 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bains V; Kaur H; Badaruddoza B
+Authors Full Name
+ Bains, Veena; Kaur, Harjit; Badaruddoza, Badaruddoza.
+Institution
+ Bains, Veena. Department of Human Genetics, Guru Nanak Dev University (GNDU), Amritsar 143 005, Punjab, India.
+ Kaur, Harjit. Department of Human Genetics, Guru Nanak Dev University (GNDU), Amritsar 143 005, Punjab, India.
+ Badaruddoza, Badaruddoza. Department of Human Genetics, Guru Nanak Dev University (GNDU), Amritsar 143 005, Punjab, India. Electronic address: doza13@yahoo.co.in.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Asian People/ge [Genetics]
+ Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Follow-Up Studies
+ *Genetic Predisposition to Disease
+ Genotype
+ Humans
+ India/ep [Epidemiology]
+ *Leptin/ge [Genetics]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Polymorphism, Single Nucleotide
+ Prognosis
+ *Receptors, Leptin/ge [Genetics]
+Keyword Heading
+ BMI
+ Haplotype
+ LD
+ LEP
+ LEPR
+ Polymorphism
+ T2DM
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Obesity is a major risk factor in aetiology of type 2 diabetes mellitus (T2DM). Leptin (LEP) is an anti-obesity hormone which regulates food intake, energy expenditure and glucose metabolism. The genetic variants in leptin and leptin receptor gene (LEPR) may play major role in the pathogenesis of T2DM and obesity. The current study aimed to investigate the association of polymorphisms in LEP (rs7799039, -2548G/A and rs2167270, 19G/A) and LEPR (rs1137101, 668A/G) gene with type 2 diabetes in North Indian Punjabi population.
+
+ METHODS: A total of 817 subjects were included for the present case-control study, consisting of 417 T2DM patients and 400 healthy controls. The anthropometric, physiometric and biochemical measurements were taken from all the subjects. The genotyping of LEP and LEPR gene variants were carried out by polymerase chain reaction based restriction fragment length polymorphism method (PCR-RFLP), followed by genotyping of 10% of the samples for each polymorphism by Sanger sequencing method for quality control measurement.
+
+ RESULTS: The risk genotype frequencies were found to be significantly higher in T2DM cases than control subjects (rs7799039, p = 0.001; rs2167270, p = 0.019 and rs1137101, p = 0.003). Under recessive genetic model LEPrs7799039 and LEPRrs1137101 polymorphism conferred 3.4 and 2.1 fold risk towards the development of T2DM after adjustment of various covariates (OR = 3.44, 95%CI: 1.768-6.681, p = 0.001 and OR: 2.12, 95%CI: 1.256-3.569, p = 0.005, respectively). In the stratified analysis of LEP variant rs7799039 by age, gender, BMI and alcohol use, a significantly increased risk of T2DM was found in female, BMI >= 23 and never drinking subgroups. However, in the LEPR variant rs1137101, significantly increased risk of T2DM was observed in age <50, male, BMI >= 23 and never drinking subgroup. The A-G haplotype combination of rs7799039A and rs2167270G conferred significant 2 fold risk towards T2DM (OR = 2.35, 95%CI: 1.34-4.12, p = 0.002). In control group, the genetic variants rs7799039 and rs1137101 were significantly associated with levels of random blood sugar and low density lipoprotein cholesterol levels.
+
+ CONCLUSION: The present study revealed the association of LEP rs7799039 and LEPR rs1137101 with type 2 diabetes mellitus, which suggest its predominant role in the estimation of type 2 diabetes mellitus in North Indian Punjabi population. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Leptin). 0 (Receptors, Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.gene.2020.144846
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bains&issn=0378-1119&title=Gene&atitle=Association+analysis+of+polymorphisms+in+LEP+%28rs7799039+and+rs2167270%29+and+LEPR+%28rs1137101%29+gene+towards+the+development+of+type+2+diabetes+in+North+Indian+Punjabi+population.&volume=754&issue=&spage=144846&epage=&date=2020&doi=10.1016%2Fj.gene.2020.144846&pmid=32512158&sid=OVID:medline
+
+<1301>
+Unique Identifier
+ 32506978
+Title
+ How to apply the personalized medicine in obesity-associated asthma?. [Review]
+Source
+ Expert Review of Respiratory Medicine. 14(9):905-915, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tiotiu A; Labor M; Nedeva D; Novakova S; Oguzulgen IK; Mihaicuta S; Braido F
+Author NameID
+ Tiotiu, Angelica; ORCID: https://orcid.org/0000-0002-8038-9559
+ Labor, Marina; ORCID: https://orcid.org/0000-0001-5216-8129
+ Braido, Fulvio; ORCID: https://orcid.org/0000-0003-2460-4709
+Authors Full Name
+ Tiotiu, Angelica; Labor, Marina; Nedeva, Denislava; Novakova, Silviya; Oguzulgen, Ipek Kivilcim; Mihaicuta, Stefan; Braido, Fulvio.
+Institution
+ Tiotiu, Angelica. Department of Pulmonology, University Hospital of Nancy, Nancy, France.
+ Tiotiu, Angelica. EA3450 DevAH - Development, Adaptation and Disadvantage, Cardio-respiratory Regulations and Motor Control, University of Lorraine, Nancy, France.
+ Labor, Marina. Department of Pulmonology, University Hospital Centre Osijek, Osijek, Croatia.
+ Labor, Marina. Medical Faculty Osijek, J.J. Strossmayer University, Osijek, Croatia.
+ Nedeva, Denislava. Medical University of Sofia, Sofia, Bulgaria.
+ Novakova, Silviya. Allergy Unit, Internal Consulting Department, University Hospital "St. George", Plovdiv, Bulgaria.
+ Oguzulgen, Ipek Kivilcim. Department of Chest Diseases, Gazi University School of Medicine, Ankara, Turkey.
+ Mihaicuta, Stefan. Babes University of Medicine and Pharmacie, Timisoara, Romania.
+ Braido, Fulvio. Respiratory and Allergy Department, University of Genoa, Ospedale Policlinico San Martino, Genoa, Italy.
+MeSH Subject Headings
+ *Asthma/et [Etiology]
+ Asthma/im [Immunology]
+ Asthma/pp [Physiopathology]
+ Asthma/th [Therapy]
+ Biomarkers
+ Female
+ Humans
+ Inflammation
+ Lung/pp [Physiopathology]
+ Male
+ *Obesity/co [Complications]
+ Obesity/im [Immunology]
+ Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ *Precision Medicine
+ Respiratory System/pa [Pathology]
+ Weight Loss
+Keyword Heading
+ Obese-asthma phenotypes
+ multidisciplinary team
+ personalized medicine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity-associated asthma (OA) is frequently severe, with an increased rate of hospitalizations, numerous comorbidities and low response to corticosteroids. Despite progress in applying for personalized medicine in asthma, no specific recommendations exist for the management of OA.
+
+ AREAS COVERED: The aim of this review is to summarize recent data about the relationship obesity-asthma, describe clinical characteristics, potential mechanisms involved and possible therapeutic interventions to improve OA outcomes. Extensive research in the PubMed was performed using the following terms: "asthma and obesity" and "obese asthma" in combination with "phenotypes", "airway inflammation", "biomarkers", "lung function", "weight loss", "lifestyle interventions", "therapies" Currently two phenotypes are described. Early-onset atopic asthma is conventional allergic asthma aggravated by the pro-inflammatory properties of adipose tissue in excess, while late-onset non-atopic asthma is due to airway dysfunction as a consequence of the chronic lung compression caused by the obese chest walls. Previous data showed that different therapeutic strategies used in weight loss have a positive impact on OA outcomes.
+
+ EXPERT OPINION: The presence of a multidisciplinary team (chest physician, nutritionist, exercise physiologist, physiotherapist, psychologist, bariatric surgeon) and the collaboration between different specialists are mandatory to optimize the management and to apply the personalized medicine in OA.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f17476348.2020.1780123
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tiotiu&issn=1747-6348&title=Expert+Review+of+Respiratory+Medicine&atitle=How+to+apply+the+personalized+medicine+in+obesity-associated+asthma%3F.&volume=14&issue=9&spage=905&epage=915&date=2020&doi=10.1080%2F17476348.2020.1780123&pmid=32506978&sid=OVID:medline
+
+<1302>
+Unique Identifier
+ 32506681
+Title
+ Evaluation of the efficacy of low-dose liraglutide in weight control among Taiwanese non-diabetes patients.
+Source
+ Journal of Diabetes Investigation. 11(6):1524-1531, 2020 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chou CA; Chuang SF
+Author NameID
+ Chou, Chien-An; ORCID: https://orcid.org/0000-0001-6348-0265
+Authors Full Name
+ Chou, Chien-An; Chuang, Shu-Fen.
+Institution
+ Chou, Chien-An. Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
+ Chou, Chien-An. Weight and Health Management Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
+ Chuang, Shu-Fen. Weight and Health Management Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
+ Chuang, Shu-Fen. Department of Nursing, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Weight
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ *Liraglutide/tu [Therapeutic Use]
+ Male
+ *Metabolic Syndrome/dt [Drug Therapy]
+ Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pa [Pathology]
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Retrospective Studies
+Keyword Heading
+ Low-dose liraglutide
+ Taiwan
+ Weight reduction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: Obesity and metabolic syndrome are well-known to be associated with multiple chronic diseases. Currently, high-dose liraglutide has been used for weight control in non-diabetic patients. Considering incretin-based therapy is more effective in Asian populations, the effect of low-dose liraglutide in weight control among these non-diabetic groups has not been well evaluated. Our study aimed to evaluate the efficacy of low-dose liraglutide in weight control among Taiwan patients.
+
+ MATERIALS AND METHODS: From July 2017 to December 2018, 46 non-diabetic patients with metabolic syndrome were included. They had received low-dose liraglutide at 0.6 or 1.2 mg per day for weight reduction for 12 weeks. After then, changes in bodyweight, waist and metabolic factors were examined. Overt bodyweight reduction was defined as a decrease of >5% within 12 weeks.
+
+ RESULTS: With 12 weeks of medication use, both groups showed statistical weight reduction. Higher doses of liraglutide had better efficacy, and 44.4% of patients in the liraglutide 1.2 mg group reached overt weight reduction, whereas just 32.1% in the 0.6 mg group had achieved this. Young age was found to be a predictor factor for a positive finding (odds ratio 0.941, P = 0.037). Early responders with decreased bodyweight of >4.2% within the first 4 weeks indicated a better chance to achieve measurable weight reduction.
+
+ CONCLUSIONS: Low-dose liraglutide still has high efficacy in weight reduction in Taiwanese people, especially for those of younger age. Copyright © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (hemoglobin A1c protein, human). 839I73S42A (Liraglutide).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fjdi.13314
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chou&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Evaluation+of+the+efficacy+of+low-dose+liraglutide+in+weight+control+among+Taiwanese+non-diabetes+patients.&volume=11&issue=6&spage=1524&epage=1531&date=2020&doi=10.1111%2Fjdi.13314&pmid=32506681&sid=OVID:medline
+
+<1303>
+Unique Identifier
+ 32499757
+Title
+ Aromatase Inhibitors Plus Weight Loss Improves the Hormonal Profile of Obese Hypogonadal Men Without Causing Major Side Effects.
+Source
+ Frontiers in Endocrinology. 11:277, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Colleluori G; Chen R; Turin CG; Vigevano F; Qualls C; Johnson B; Mediwala S; Villareal DT; Armamento-Villareal R
+Authors Full Name
+ Colleluori, Georgia; Chen, Rui; Turin, Christie G; Vigevano, Francesca; Qualls, Clifford; Johnson, Biju; Mediwala, Sanjay; Villareal, Dennis T; Armamento-Villareal, Reina.
+Institution
+ Colleluori, Georgia. Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, United States.
+ Colleluori, Georgia. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
+ Chen, Rui. Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, United States.
+ Chen, Rui. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
+ Turin, Christie G. Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, United States.
+ Turin, Christie G. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
+ Vigevano, Francesca. Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, United States.
+ Vigevano, Francesca. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
+ Qualls, Clifford. Division of Mathematics and Statistics, University of New Mexico School of Medicine, Albuquerque, NM, United States.
+ Johnson, Biju. Research Pharmacy, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
+ Mediwala, Sanjay. Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, United States.
+ Mediwala, Sanjay. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
+ Villareal, Dennis T. Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, United States.
+ Villareal, Dennis T. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
+ Armamento-Villareal, Reina. Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, United States.
+ Armamento-Villareal, Reina. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
+MeSH Subject Headings
+ Adult
+ Aged
+ Androgens/bl [Blood]
+ Aromatase Inhibitors
+ *Biomarkers/bl [Blood]
+ *Body Composition
+ *Bone Density
+ Bone and Bones/de [Drug Effects]
+ *Bone and Bones/ph [Physiology]
+ Double-Blind Method
+ Estradiol/bl [Blood]
+ Follow-Up Studies
+ Hormone Replacement Therapy
+ Humans
+ Hypogonadism/co [Complications]
+ Hypogonadism/me [Metabolism]
+ Hypogonadism/pa [Pathology]
+ *Hypogonadism/th [Therapy]
+ Male
+ Metabolome
+ Middle Aged
+ Muscle Strength
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ *Obesity/th [Therapy]
+ Pilot Projects
+ Prognosis
+ Testosterone/bl [Blood]
+ *Weight Loss
+Keyword Heading
+ aromatase inhibitors
+ body composition
+ bone density
+ bone microarchitecture
+ hypogonadism
+ obesity
+ sex hormones
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: In obese men, the increased expression of the aromatase enzyme in adipose tissue leads to high conversion of androgens to estrogens contributing to hypogonadotropic hypogonadism (HHG). Our objective is to evaluate efficacy and safety of weight loss (WL) plus aromatase inhibitor (AI) therapy in severely obese men with HHG. We hypothesize that AI+WL will be more effective as compared to WL alone in improving the hormonal profile, thus muscle strength and symptoms of HHG (primary outcomes), with no significant adverse effects on lean mass, metabolic profile, and bone mineral density (secondary outcomes). Design: Randomized double-blind placebo-controlled pilot trial. Methods: Twenty-three obese men (BMI>=35 kg/m2), 35-65 years old, were randomized to weight loss (diet and exercise) plus either anastrozole (AI+WL, n = 12) at 1 mg daily or placebo (PBO+WL, n = 11) for 6 months. Inclusion criteria: total testosterone <300 ng/mL (average of 2 measurements), estradiol>=10.9 pg/ml, LH <9 IU/l. Symptoms of hypogonadism by questionnaires; muscle strength by Biodex dynamometer; body composition and bone mineral density by dual-energy X-ray absorptiometry; bone microarchitecture and finite element analysis by high resolution peripheral quantitative-computed tomography. Results: After 6 months of therapy, AI+WL group had higher testosterone (p = 0.003) and lower estradiol (p = 0.001) compared to PBO+WL. Changes in symptoms and muscle strength did not differ between groups. AI+WL resulted in higher fat mass loss than PBO+WL (p = 0.04) without differences in changes in lean mass. Total and LDL cholesterol reduced more in the PBO+WL group compared to AI+WL (p = 0.03 for both), who experienced a minimal increase with unlikely meaningful clinical impact. Tibial trabecular bone area decreased more in PBO+WL than AI+WL group for which it remained stable (p = 0.03). Conclusions: Although AI+WL is effective in reversing the hormonal profile of HHG in severely obese men without causing major side effects, it does not lead to greater improvements in muscle strength and symptoms of hypogonadism compared to WL alone. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT02959853. Copyright © 2020 Colleluori, Chen, Turin, Vigevano, Qualls, Johnson, Mediwala, Villareal and Armamento-Villareal.
+Registry Number/Name of Substance
+ 0 (Androgens). 0 (Aromatase Inhibitors). 0 (Biomarkers). 3XMK78S47O (Testosterone). 4TI98Z838E (Estradiol).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3389%2ffendo.2020.00277
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Colleluori&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Aromatase+Inhibitors+Plus+Weight+Loss+Improves+the+Hormonal+Profile+of+Obese+Hypogonadal+Men+Without+Causing+Major+Side+Effects.&volume=11&issue=&spage=277&epage=&date=2020&doi=10.3389%2Ffendo.2020.00277&pmid=32499757&sid=OVID:medline
+
+<1304>
+Unique Identifier
+ 32498937
+Title
+ Risk factors for insulin resistance in midlife Singaporean women.
+Source
+ Maturitas. 137:50-56, 2020 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sundstrom-Poromaa I; Thu WPP; Kramer MS; Logan S; Cauley JA; Yong EL
+Authors Full Name
+ Sundstrom-Poromaa, Inger; Thu, Win Pa Pa; Kramer, Michael S; Logan, Susan; Cauley, Jane A; Yong, Eu-Leong.
+Institution
+ Sundstrom-Poromaa, Inger. Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, Singapore 119228; Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, Sweden.
+ Thu, Win Pa Pa. Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, Singapore 119228.
+ Kramer, Michael S. Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, Singapore 119228; Departments of Epidemiology, Biostatistics & Occupational Health and of Pediatrics, McGill University Faculty of Medicine, Montreal, QC H3G 1Y6, Canada.
+ Logan, Susan. Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, Singapore 119228.
+ Cauley, Jane A. Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, United States.
+ Yong, Eu-Leong. Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, Singapore 119228. Electronic address: obgyel@nus.edu.sg.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ China/eh [Ethnology]
+ Exercise
+ Female
+ Hand Strength
+ Humans
+ India/eh [Ethnology]
+ Insulin
+ *Insulin Resistance/eh [Ethnology]
+ *Interleukin-6/bl [Blood]
+ *Intra-Abdominal Fat
+ Malaysia/eh [Ethnology]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Physical Functional Performance
+ Risk Factors
+ Singapore
+ *Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ Ethnicity
+ Inflammation
+ Insulin resistance
+ Midlife women
+ SPPB
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To understand the extent to which risk factors for insulin resistance are mediated by body mass index (BMI), visceral adipose tissue (VAT), physical activity and performance, and the inflammatory markers interleukin (IL)-6, tumor necrosis factor (TNF)- alpha, and high-sensitivity C-reactive protein (hs-CRP).
+
+ STUDY DESIGN: A wide range of socio-demographic characteristics of Chinese, Malay and Indian women attending routine gynecologic care in Singapore were prospectively collected. Physical performance was objectively measured by hand grip strength and the Short Physical Performance Battery. Percent VAT was determined by dual-energy X-ray absorptiometry. Fasting serum concentrations of glucose, insulin, IL-6, TNF- alpha, and hs-CRP were measured.
+
+ MAIN OUTCOME MEASURE: was insulin resistance, expressed as the homeostatic model assessment of insulin resistance (HOMA-IR).
+
+ RESULTS: 1159 women were analyzed, mean age 56.3 (range 45-69) years, comprising women of Chinese (84.0%), Indian (10.2%), and Malay (5.7%) ethnic origins. The adjusted mean differences for obesity (0.66, 95% CI 0.32-1.00), VAT area in the highest vs lowest tertile (1.03, 95% CI 0.73-1.34), low physical performance (0.63, 95% CI 0.05-1.24), and highest vs lowest tertile of TNF- alpha (0.35, 95% CI 0.13-0.57) were independently associated with HOMA-IR. Women of Malay and Indian ethnicity had higher crude HOMA-IR than Chinese women. However, after adjustment for obesity, VAT, physical performance, and TNF- alpha, no differences in mean HOMA-IR remained, when comparing Chinese women with those of Malay ethnicity (0.27, 95% CI -0.12 to 0.66) and with those of Indian ethnicity (0.30, 95% CI -0.01 to 0.66).
+
+ CONCLUSIONS: Insulin resistance was independently associated with obesity, high VAT, low physical performance, and high levels of TNF- alpha in midlife Singaporean women. These variables entirely explained the significant differences in insulin resistance between women of Chinese, Malay and Indian ethnicity. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (IL6 protein, human). 0 (Insulin). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.maturitas.2020.04.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sundstrom-Poromaa&issn=0378-5122&title=Maturitas&atitle=Risk+factors+for+insulin+resistance+in+midlife+Singaporean+women.&volume=137&issue=&spage=50&epage=56&date=2020&doi=10.1016%2Fj.maturitas.2020.04.003&pmid=32498937&sid=OVID:medline
+
+<1305>
+Unique Identifier
+ 32497454
+Title
+ The effect of low-volume high-intensity interval training on cardiometabolic health and psychological responses in overweight/obese middle-aged men.
+Source
+ Journal of Sports Sciences. 38(17):1997-2004, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Poon ET; Little JP; Sit CH; Wong SH
+Author NameID
+ Poon, Eric Tsz-Chun; ORCID: https://orcid.org/0000-0002-0842-1323
+ Little, Jonathan Peter; ORCID: https://orcid.org/0000-0002-9796-2008
+ Sit, Cindy Hui-Ping; ORCID: https://orcid.org/0000-0001-9992-7866
+ Wong, Stephen Heung-Sang; ORCID: https://orcid.org/0000-0002-6821-4545
+Authors Full Name
+ Poon, Eric Tsz-Chun; Little, Jonathan Peter; Sit, Cindy Hui-Ping; Wong, Stephen Heung-Sang.
+Institution
+ Poon, Eric Tsz-Chun. Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Shatin, Hong Kong.
+ Little, Jonathan Peter. School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
+ Sit, Cindy Hui-Ping. Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Shatin, Hong Kong.
+ Wong, Stephen Heung-Sang. Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Shatin, Hong Kong.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure/ph [Physiology]
+ Body Fat Distribution
+ Body Mass Index
+ Cardiorespiratory Fitness/ph [Physiology]
+ Cardiorespiratory Fitness/px [Psychology]
+ *Cardiorespiratory Fitness
+ Cholesterol, HDL/bl [Blood]
+ *Exercise Therapy/mt [Methods]
+ Glycated Hemoglobin/me [Metabolism]
+ *High-Intensity Interval Training
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/px [Psychology]
+ *Obesity/th [Therapy]
+ Overweight/bl [Blood]
+ *Overweight/px [Psychology]
+ *Overweight/th [Therapy]
+ Patient Compliance
+ Pleasure
+ Time Factors
+ Waist Circumference
+ Weight Loss
+Keyword Heading
+ High-intensity interval training
+ cardiometabolic health
+ interval exercise
+ psychological responses
+ public health
+ weight management
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ High-intensity interval training (HIIT) has been proposed as a time-efficient exercise protocol to improve metabolic health, but direct comparisons with higher-volume moderate-intensity continuous training (MICT) under unsupervised settings are limited. This study compared low-volume HIIT and higher-volume MICT interventions on cardiometabolic and psychological responses in overweight/obese middle-aged men. Twenty-four participants (age: 48.1+/-5.2yr; BMI: 25.8+/-2.3kg.m-2) were randomly assigned to undertake either HIIT (10 X 1-min bouts of running at 80-90% HRmax separated by 1-min active recovery) or MICT (50-min continuous jogging/brisk walking at 65-70% HRmax) for 3 sessions/week for 8 weeks (2-week supervised + 6-week unsupervised training). Both groups showed similar cardiovascular fitness (VO2max) improvement (HIIT: 32.5+/-5.6 to 36.0+/-6.2; MICT: 34.3+/-6.0 to 38.2+/-5.1mL kg-1 min-1, p < 0.05) and %fat loss (HIIT: 24.5+/-3.4 to 23.2+/-3.5%; MICT: 23.0+/-4.3 to 21.5+/-4.1%, p< 0.05) over the 8-week intervention. Compared to baseline, MICT significantly decreased weight and waist circumference. No significant group differences were observed for blood pressure and cardiometabolic blood markers such as lipid profiles, fasting glucose and glycated haemoglobin. Both groups showed similar enjoyment levels and high unsupervised adherence rates (>90%). Our findings suggest that low-volume HIIT can elicit a similar improvement of cardiovascular fitness as traditional higher-volume MICT in overweight/obese middle-aged men.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1080%2f02640414.2020.1766178
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Poon&issn=0264-0414&title=Journal+of+Sports+Sciences&atitle=The+effect+of+low-volume+high-intensity+interval+training+on+cardiometabolic+health+and+psychological+responses+in+overweight%2Fobese+middle-aged+men.&volume=38&issue=17&spage=1997&epage=2004&date=2020&doi=10.1080%2F02640414.2020.1766178&pmid=32497454&sid=OVID:medline
+
+<1306>
+Unique Identifier
+ 32495930
+Title
+ Circulating vaspin levels and nutritional status and insulin resistance in polycystic ovary syndrome.
+Source
+ Ginekologia Polska. 91(5):251-255, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Franik G; Plinta R; Madej P; Owczarek A; Bozentowicz-Wikarek M; Chudek J; Skrzypulec-Plinta V; Olszanecka-Glinianowicz M
+Author NameID
+ Skrzypulec-Plinta, Violetta; ORCID: https://orcid.org/0000-0001-5632-5590
+Authors Full Name
+ Franik, Grzegorz; Plinta, Ryszard; Madej, Pawel; Owczarek, Aleksander; Bozentowicz-Wikarek, Maria; Chudek, Jerzy; Skrzypulec-Plinta, Violetta; Olszanecka-Glinianowicz, Magdalena.
+Institution
+ Franik, Grzegorz. Department of Gynecological Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Poland.
+ Plinta, Ryszard. Chair of Physiotherapy, School of Health Science in Katowice, Medical University of Silesia, Poland.
+ Madej, Pawel. Department of Gynecological Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Poland.
+ Owczarek, Aleksander. Department of Statistics, Department of Instrumental Analysis, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Poland.
+ Bozentowicz-Wikarek, Maria. Pathophysiology Unit, Department of Pathophysiology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland.
+ Chudek, Jerzy. Pathophysiology Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Poland.
+ Chudek, Jerzy. Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice, Medical University of Silesia, Poland.
+ Skrzypulec-Plinta, Violetta. Women's Health Chair, School of Health Science in Katowice, Medical University of Silesia, Poland.
+ Olszanecka-Glinianowicz, Magdalena. Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Poland. magolsza@gmail.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ Body Composition
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Insulin Resistance
+ *Nutritional Status
+ Obesity
+ Polycystic Ovary Syndrome/bl [Blood]
+ *Polycystic Ovary Syndrome/di [Diagnosis]
+ Predictive Value of Tests
+ *Serpins/bl [Blood]
+ Young Adult
+Keyword Heading
+ PCOS
+ insulin resistance
+ nutritional status
+ vaspin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: The study aimed to assess the associations between circulating vaspin levels and nutritional status (assessed on tha basis of BMI) as well as insulin resistance in PCOS.
+
+ MATERIAL AND METHODS: Eighty-seven PCOS women, 48 obese and 39 normal weight, were enrolled in the cross-sectional study. Seventy-two Non-PCOS women, 41 obese and 31 normal weight, constituted a control group. Body mass, height and waist circumference as well as body composition by bioimpedance were measured. In the morning (16h after the last meal) we determined: serum glucose, insulin, androgens, gonadotropin (LH, FSH) and sex hormone-binding globulin (SHBG) as well as plasma vaspin levels. Standard HOMA-IR formula was used to assess insulin resistance (IR).
+
+ RESULTS: Plasma vaspin levels were significantly lower in PCOS, both normal weight and obese, than in Non-PCOS groups. Vaspin levels were similar in normal weight and obese PCOS subgroups. There was no association between plasma vaspin levels and anthropometric parameters in PCOS group. While in Non-PCOS group a negative correlation between plasma vaspin levels and body mass (r = -0.26; p < 0.05) was found. We did not observe correlations between plasma vaspin levels and serum glucose and insulin concentrations as well as HOMA-IR values, however, in multivariable, stepwise backward regression waist circumference and HOMA-IR values explained 18.0% of plasma vaspin levels variability in the study subjects.
+
+ CONCLUSIONS: PCOS occurrence is associated with decreased vaspin levels. The influence of nutritional status on vaspin level observed in Non-PCOS is abolished in PCOS women, possibly by more severe insulin resistance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (SERPINA12 protein, human). 0 (Serpins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.5603%2fGP.2020.0056
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Franik&issn=0017-0011&title=Ginekologia+Polska&atitle=Circulating+vaspin+levels+and+nutritional+status+and+insulin+resistance+in+polycystic+ovary+syndrome.&volume=91&issue=5&spage=251&epage=255&date=2020&doi=10.5603%2FGP.2020.0056&pmid=32495930&sid=OVID:medline
+
+<1307>
+Unique Identifier
+ 32493188
+Title
+ Adipokines as Potential Biomarkers in the Neurorehabilitation of Obese Stroke Patients.
+Source
+ Current Neurovascular Research. 17(4):437-445, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ciancarelli I; Morone G; Iosa M; Paolucci S; Pignolo L; Tonin P; Cerasa A; Ciancarelli MGT
+Authors Full Name
+ Ciancarelli, Irene; Morone, Giovanni; Iosa, Marco; Paolucci, Stefano; Pignolo, Loris; Tonin, Paolo; Cerasa, Antonio; Ciancarelli, Maria Giuliana Tozzi.
+Institution
+ Ciancarelli, Irene. Department of Life, Health and Environmental Sciences, University of L'Aquila-67100, L'Aquila, Italy.
+ Morone, Giovanni. Santa Lucia Foundation, Scientific Institute for Hospitalization and Health Care, 00179 Rome, Italy.
+ Iosa, Marco. Santa Lucia Foundation, Scientific Institute for Hospitalization and Health Care, 00179 Rome, Italy.
+ Paolucci, Stefano. Santa Lucia Foundation, Scientific Institute for Hospitalization and Health Care, 00179 Rome, Italy.
+ Pignolo, Loris. S. Anna Rehabilitation Institute, Research on Advanced Neurorehabilitation, 88900 Crotone, Italy.
+ Tonin, Paolo. S. Anna Rehabilitation Institute, Research on Advanced Neurorehabilitation, 88900 Crotone, Italy.
+ Cerasa, Antonio. S. Anna Rehabilitation Institute, Research on Advanced Neurorehabilitation, 88900 Crotone, Italy.
+ Ciancarelli, Maria Giuliana Tozzi. Department of Life, Health and Environmental Sciences, University of L'Aquila-67100, L'Aquila, Italy.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ *Brain Ischemia/bl [Blood]
+ Brain Ischemia/di [Diagnosis]
+ Brain Ischemia/rh [Rehabilitation]
+ Cohort Studies
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Neurological Rehabilitation/mt [Methods]
+ Neurological Rehabilitation/td [Trends]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/rh [Rehabilitation]
+ *Stroke/bl [Blood]
+ Stroke/di [Diagnosis]
+ Stroke Rehabilitation/mt [Methods]
+ Stroke Rehabilitation/td [Trends]
+Keyword Heading
+ Leptin
+ adiponectin
+ functional recovery
+ neurorehabilitation
+ obese stroke patients
+ resistin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Limited studies concern the influence of obesity-induced dysregulation of adipokines in functional recovery after stroke neurorehabilitation.
+
+ OBJECTIVE: To investigate the relationship between serum leptin, resistin, and adiponectin and functional recovery before and after neurorehabilitation of obese stroke patients. The adipokine potential significance as prognostic markers of rehabilitation outcomes was also verified.
+
+ METHODS: Twenty obese post-acute stroke patients before and after neurorehabilitation and thirteen obese volunteers without-stroke, as controls, were examined. Adipokines were determined by commercially available enzyme-linked immunosorbent assay (ELISA) kits. Functional deficits were assessed before and after neurorehabilitation with the Barthel Index (BI), modified Rankin Scale (mRS), and Functional Independence Measure (FIM).
+
+ RESULTS: Compared to controls, higher leptin and resistin values and lower adiponectin values were observed in stroke patients before neurorehabilitation and no correlations were found between adipokines and clinical outcome measures. Neurorehabilitation was associated with improved scores of BI, mRS, and FIM. After neurorehabilitation, decreased values of Body Mass Index (BMI) and resistin together increased adiponectin were detected in stroke patients, while leptin decreased but not statistically. Comparing adipokine values assessed before neurorehabilitation with the outcome measures after neurorehabilitation, correlations were observed for leptin with BI-score, mRS-score, and FIM-score. No other adipokine levels nor BMI assessed before neurorehabilitation correlated with the clinical measures after neurorehabilitation. The forward stepwise regression analysis identified leptin as prognostic factor for BI, mRS, and FIM.
+
+ CONCLUSION: Our data show the effectiveness of neurorehabilitation in modulating adipokines levels and suggest that leptin could assume the significance of biomarker of functional recovery. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.2174%2f1567202617666200603150901
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ciancarelli&issn=1567-2026&title=Current+Neurovascular+Research&atitle=Adipokines+as+Potential+Biomarkers+in+the+Neurorehabilitation+of+Obese+Stroke+Patients.&volume=17&issue=4&spage=437&epage=445&date=2020&doi=10.2174%2F1567202617666200603150901&pmid=32493188&sid=OVID:medline
+
+<1308>
+Unique Identifier
+ 32489798
+Title
+ Early Stages of Obesity-related Heart Failure Are Associated with Natriuretic Peptide Deficiency and an Overall Lack of Neurohormonal Activation: The Copenhagen Heart Failure Risk Study.
+Source
+ Global heart. 15(1):25, 2020 03 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gaborit FS; Kistorp C; Kumler T; Hassager C; Tonder N; Iversen K; Kamstrup PR; Faber J; Kober L; Schou M
+Authors Full Name
+ Gaborit, Freja Stoltze; Kistorp, Caroline; Kumler, Thomas; Hassager, Christian; Tonder, Niels; Iversen, Kasper; Kamstrup, Pia R; Faber, Jens; Kober, Lars; Schou, Morten.
+Institution
+ Gaborit, Freja Stoltze. Department of Cardiology, Herlev Gentofte University Hospital, DK.
+ Gaborit, Freja Stoltze. Faculty of Health and Medical Science, University of Copenhagen, DK.
+ Kistorp, Caroline. Department Endocrinology, Rigshospitalet, Copenhagen, DK.
+ Kistorp, Caroline. Department of Clinical Medicine, University of Copenhagen, DK.
+ Kumler, Thomas. Department of Cardiology, Herlev Gentofte University Hospital, DK.
+ Hassager, Christian. Department of Cardiology, Rigshospitalet, Copenhagen, DK.
+ Hassager, Christian. Department of Clinical Medicine, University of Copenhagen, DK.
+ Tonder, Niels. Department of Cardiology, North Zealand University Hospital, DK.
+ Iversen, Kasper. Department of Cardiology, Herlev Gentofte University Hospital, DK.
+ Iversen, Kasper. Department of Clinical Medicine, University of Copenhagen, DK.
+ Kamstrup, Pia R. Department of Clinical Biochemistry, Herlev Gentofte University Hospital, DK.
+ Faber, Jens. Department Endocrinology, Rigshospitalet, Copenhagen, DK.
+ Faber, Jens. Department Endocrinology, Herlev Gentofte University Hospital, DK.
+ Kober, Lars. Department of Cardiology, Rigshospitalet, Copenhagen, DK.
+ Kober, Lars. Department of Clinical Medicine, University of Copenhagen, DK.
+ Schou, Morten. Department of Cardiology, Herlev Gentofte University Hospital, DK.
+ Schou, Morten. Department of Clinical Medicine, University of Copenhagen, DK.
+MeSH Subject Headings
+ *Adrenomedullin/bl [Blood]
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Denmark/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Heart Failure/bl [Blood]
+ Heart Failure/ep [Epidemiology]
+ *Heart Failure/et [Etiology]
+ Humans
+ Male
+ *Natriuretic Peptide, Brain/bl [Blood]
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ *Peptide Fragments/bl [Blood]
+ Prevalence
+ Prospective Studies
+ Protein Precursors
+Keyword Heading
+ heart failure
+ natriuretic peptide
+ neurohormonal activation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: This study evaluated the associations between the natriuretic peptide activity and the neurohormonal response in non-obese and obese outpatients with and without heart failure (HF).
+
+ Background: Obesity-related HF may be a distinct subtype of HF. Obesity is associated with lower plasma concentrations of natriuretic peptides. The associations between obesity and neurohormonal activation estimated by mid-regional pro-adrenomedullin (MR-proADM) and copeptin in patients with HF is not elucidated.
+
+ Methods: This prospective cohort-study included 392 outpatients >=60years, plus >=1 risk-factor(-s) for HF (hypertension, ischemic heart disease, atrial fibrillation, diabetes, chronic kidney disease), and without known HF. Patients were categorized 'non-obese' BMI = 18.5-29.9 kg/m2 (n = 273) and 'obese' BMI >= 30 kg/m2 (n = 119). The diagnosis of HF required signs, symptoms, and abnormal echocardiography. NT-proBNP, MR-proANP, MR-proADM, and copeptin were analyzed.
+
+ Results: Obese patients were younger, had a higher prevalence of diabetes and chronic kidney disease, but a lower prevalence of atrial fibrillation. A total of 39 (14.3%) non-obese and 26 (21.8%) obese patients were diagnosed with HF. In obese patients, HF was not associated with higher plasma concentrations of NT-proBNP (Estimate: 0.063; 95%CI: -0.037-1.300; P = 0.064), MR-proANP (Estimate: 0.207; 95%CI: -0.101-0.515; P = 0.187), MR-proADM (Estimate: 0.112; 95%CI: -0.047-0.271; P = 0.168), or copeptin (Estimate: 0.093; 95%CI: -0.333-0.518; P = 0.669). Additionally, obese patients with HF had lower plasma concentrations of NT-proBNP (Estimate: -0.998; 95%CI: -1.778-0.218; P = 0.012), and MR-proANP (Estimate: -0.488; 95%CI: -0.845-0.132; P = 0.007) compared to non-obese patients with HF, whereas plasma concentrations of MR-proADM (Estimate: 0.066; 95%CI: -0.119-0.250; P = 0.484) and copeptin (Estimate: 0.140; 95%CI: -0.354-0.633; P = 0.578) were comparable.
+
+ Conclusions: Patients with obesity-related HF have natriuretic peptide deficiency and lack of increased plasma concentrations of MR-proADM and copeptin suggesting that patients with obesity-related HF have a blunted overall neurohormonal activity. Copyright: © 2020 The Author(s).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (Protein Precursors). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain). 148498-78-6 (Adrenomedullin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.5334%2fgh.776
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gaborit&issn=2211-8160&title=Global+heart&atitle=Early+Stages+of+Obesity-related+Heart+Failure+Are+Associated+with+Natriuretic+Peptide+Deficiency+and+an+Overall+Lack+of+Neurohormonal+Activation%3A+The+Copenhagen+Heart+Failure+Risk+Study.&volume=15&issue=1&spage=25&epage=&date=2020&doi=10.5334%2Fgh.776&pmid=32489798&sid=OVID:medline
+
+<1309>
+Unique Identifier
+ 32482712
+Title
+ Association between Subcutaneous Adipose Tissue Inflammation, Insulin Resistance, and Calorie Restriction in Obese Females.
+Source
+ Journal of Immunology. 205(1):45-55, 2020 07 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sbierski-Kind J; Mai K; Kath J; Jurisch A; Streitz M; Kuchenbecker L; Babel N; Nienen M; Jurchott K; Spranger L; Jumpertz von Schwartzenberg R; Decker AM; Kruger U; Volk HD; Spranger J
+Author NameID
+ Sbierski-Kind, Julia; ORCID: https://orcid.org/0000-0001-7133-5332
+ Kuchenbecker, Leon; ORCID: https://orcid.org/0000-0002-9479-1872
+ Spranger, Leonard; ORCID: https://orcid.org/0000-0002-4316-2961
+ Decker, Anne-Marie; ORCID: https://orcid.org/0000-0003-2237-0507
+Authors Full Name
+ Sbierski-Kind, Julia; Mai, Knut; Kath, Jonas; Jurisch, Anke; Streitz, Mathias; Kuchenbecker, Leon; Babel, Nina; Nienen, Mikalai; Jurchott, Karsten; Spranger, Leonard; Jumpertz von Schwartzenberg, Reiner; Decker, Anne-Marie; Kruger, Ulrike; Volk, Hans-Dieter; Spranger, Joachim.
+Institution
+ Sbierski-Kind, Julia. Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Department of Endocrinology and Metabolism, Berlin Institute of Health, 10178 Berlin, Germany; julia.sbierski-kind@charite.de.
+ Sbierski-Kind, Julia. Berlin Institute of Health, 10178 Berlin, Germany.
+ Sbierski-Kind, Julia. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Sbierski-Kind, Julia. Institute for Medical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Mai, Knut. Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Department of Endocrinology and Metabolism, Berlin Institute of Health, 10178 Berlin, Germany.
+ Mai, Knut. Berlin Institute of Health, 10178 Berlin, Germany.
+ Mai, Knut. Charite - Center for Cardiovascular Research, 10117 Berlin, Germany.
+ Kath, Jonas. Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Department of Endocrinology and Metabolism, Berlin Institute of Health, 10178 Berlin, Germany.
+ Kath, Jonas. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Jurisch, Anke. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Jurisch, Anke. Institute for Medical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Streitz, Mathias. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Streitz, Mathias. Institute for Medical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Kuchenbecker, Leon. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Kuchenbecker, Leon. Institute for Medical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Babel, Nina. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Babel, Nina. Center for Translational Medicine, Department of Internal Medicine I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, 44625 Bochum, Germany.
+ Nienen, Mikalai. Berlin Institute of Health, 10178 Berlin, Germany.
+ Nienen, Mikalai. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Nienen, Mikalai. Center for Translational Medicine, Department of Internal Medicine I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, 44625 Bochum, Germany.
+ Jurchott, Karsten. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Jurchott, Karsten. Institute for Medical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Spranger, Leonard. Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Department of Endocrinology and Metabolism, Berlin Institute of Health, 10178 Berlin, Germany.
+ Spranger, Leonard. Charite - Center for Cardiovascular Research, 10117 Berlin, Germany.
+ Jumpertz von Schwartzenberg, Reiner. Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Department of Endocrinology and Metabolism, Berlin Institute of Health, 10178 Berlin, Germany.
+ Jumpertz von Schwartzenberg, Reiner. Berlin Institute of Health, 10178 Berlin, Germany.
+ Jumpertz von Schwartzenberg, Reiner. Charite - Center for Cardiovascular Research, 10117 Berlin, Germany.
+ Jumpertz von Schwartzenberg, Reiner. German Center for Cardiovascular Research, partner site Berlin, 13353 Berlin, Germany; and.
+ Decker, Anne-Marie. Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Department of Endocrinology and Metabolism, Berlin Institute of Health, 10178 Berlin, Germany.
+ Decker, Anne-Marie. Berlin Institute of Health, 10178 Berlin, Germany.
+ Kruger, Ulrike. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Kruger, Ulrike. Institute for Medical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Volk, Hans-Dieter. Berlin Institute of Health Center for Regenerative Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Volk, Hans-Dieter. Institute for Medical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Volk, Hans-Dieter. Berlin Center for Advanced Therapies, Charite University Medicine Berlin, 10117 Berlin, Germany.
+ Spranger, Joachim. Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Department of Endocrinology and Metabolism, Berlin Institute of Health, 10178 Berlin, Germany.
+ Spranger, Joachim. Berlin Institute of Health, 10178 Berlin, Germany.
+ Spranger, Joachim. Charite - Center for Cardiovascular Research, 10117 Berlin, Germany.
+ Spranger, Joachim. German Center for Cardiovascular Research, partner site Berlin, 13353 Berlin, Germany; and.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Caloric Restriction
+ Cytokines/bl [Blood]
+ Cytokines/me [Metabolism]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/di [Diagnosis]
+ Inflammation/dh [Diet Therapy]
+ Inflammation/im [Immunology]
+ *Insulin Resistance/im [Immunology]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ *Obesity/im [Immunology]
+ Obesity/me [Metabolism]
+ Pilot Projects
+ Prospective Studies
+ *Subcutaneous Fat/im [Immunology]
+ T-Lymphocyte Subsets/im [Immunology]
+ T-Lymphocyte Subsets/me [Metabolism]
+ T-Lymphocytes/im [Immunology]
+ T-Lymphocytes/me [Metabolism]
+ *Weight Loss/im [Immunology]
+Abstract
+ The worldwide epidemic of overweight and obesity has led to an increase in associated metabolic comorbidities. Obesity induces chronic low-grade inflammation in white adipose tissue (WAT). However, the function and regulation of both innate and adaptive immune cells in human WAT under conditions of obesity and calorie restriction (CR) is not fully understood yet. Using a randomized interventional design, we investigated postmenopausal overweight or obese female subjects who either underwent CR for 3 mo followed by a 4-wk phase of weight maintenance or had to maintain a stable weight over the whole study period. A comprehensive immune phenotyping protocol was conducted using validated multiparameter flow cytometry analysis in blood and s.c. WAT (SAT). The TCR repertoire was analyzed by next-generation sequencing and cytokine levels were determined in SAT. Metabolic parameters were determined by hyperinsulinemic-euglycemic clamp. We found that insulin resistance correlates significantly with a shift toward the memory T cell compartment in SAT. TCR analysis revealed a diverse repertoire in SAT of overweight or obese individuals. Additionally, whereas weight loss improved systemic insulin sensitivity in the intervention group, SAT displayed no significant improvement of inflammatory parameters (cytokine levels and leukocyte subpopulations) compared with the control group. Our data demonstrate the accumulation of effector memory T cells in obese SAT and an association between systemic glucose homeostasis and inflammatory parameters in obese females. The long-standing effect of obesity-induced changes in SAT was demonstrated by preserved immune cell composition after short-term CR-induced weight loss. Copyright © 2020 by The American Association of Immunologists, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.4049%2fjimmunol.2000108
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sbierski-Kind&issn=0022-1767&title=Journal+of+Immunology&atitle=Association+between+Subcutaneous+Adipose+Tissue+Inflammation%2C+Insulin+Resistance%2C+and+Calorie+Restriction+in+Obese+Females.&volume=205&issue=1&spage=45&epage=55&date=2020&doi=10.4049%2Fjimmunol.2000108&pmid=32482712&sid=OVID:medline
+
+<1310>
+Unique Identifier
+ 32479985
+Title
+ Selective CD8 cell reduction by SARS-CoV-2 is associated with a worse prognosis and systemic inflammation in COVID-19 patients.
+Source
+ Clinical Immunology. 217:108486, 2020 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Urra JM; Cabrera CM; Porras L; Rodenas I
+Authors Full Name
+ Urra, J M; Cabrera, C M; Porras, L; Rodenas, I.
+Institution
+ Urra, J M. Immunology, Hospital General Universitario de Ciudad Real, Spain; Immunology, Facultad de Medicina de Ciudad Real, Spain. Electronic address: jmurra@sescam.jccm.es.
+ Cabrera, C M. Immunology, Hospital General Universitario de Ciudad Real, Spain; Immunology, Facultad de Medicina de Ciudad Real, Spain.
+ Porras, L. Internal Medicine, Hospital General Universitario de Ciudad Real, Spain.
+ Rodenas, I. Immunology, Hospital General Universitario de Ciudad Real, Spain.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Betacoronavirus/im [Immunology]
+ *Betacoronavirus/py [Pathogenicity]
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ CD4-Positive T-Lymphocytes/im [Immunology]
+ CD4-Positive T-Lymphocytes/pa [Pathology]
+ CD4-Positive T-Lymphocytes/vi [Virology]
+ CD8-Positive T-Lymphocytes/im [Immunology]
+ *CD8-Positive T-Lymphocytes/pa [Pathology]
+ CD8-Positive T-Lymphocytes/vi [Virology]
+ COVID-19
+ Case-Control Studies
+ Coronavirus Infections/co [Complications]
+ *Coronavirus Infections/im [Immunology]
+ Coronavirus Infections/mo [Mortality]
+ Coronavirus Infections/th [Therapy]
+ Female
+ Humans
+ Intensive Care Units
+ Lymphocyte Count
+ Lymphopenia/co [Complications]
+ *Lymphopenia/im [Immunology]
+ Lymphopenia/mo [Mortality]
+ Lymphopenia/th [Therapy]
+ Male
+ Middle Aged
+ Neutrophils/im [Immunology]
+ *Neutrophils/pa [Pathology]
+ Neutrophils/vi [Virology]
+ Obesity/co [Complications]
+ *Obesity/im [Immunology]
+ Obesity/mo [Mortality]
+ Obesity/th [Therapy]
+ Pandemics
+ Pneumonia, Viral/co [Complications]
+ *Pneumonia, Viral/im [Immunology]
+ Pneumonia, Viral/mo [Mortality]
+ Pneumonia, Viral/th [Therapy]
+ Prognosis
+ Respiration, Artificial
+ Retrospective Studies
+ SARS-CoV-2
+ Severity of Illness Index
+ Survival Analysis
+Abstract
+ The lymphopenia exhibited in patients with COVID-19 has been associated with a worse prognosis in the development of the disease. To understand the factors associated with a worse evolution of COVID-19, we analyzed comorbidities, indicators of inflammation such as CRP and the ratio of neutrophils/lymphocytes, as well as the count of blood cells with T-lymphocyte subtypes in 172 hospitalized patients with COVID-19 pneumonia. Patients were grouped according to their needs for mechanical ventilation (ICU care) or not. Within the comorbidities studied, obesity was the only associated with greater severity and ICU admission. Both the percentage and the absolute number of neutrophils were higher in patients needing ICU care than non-ICU patients, whereas absolute lymphocyte count, and especially the percentage of lymphocytes, presented a deep decline in critical patients. There was no difference between the two groups of patients for CD4 T-lymphocytes, neither in percentage of lymphocyte nor in absolute number, however for CD8 T-cells the differences were significant for both parameters which were in decline in ICU patients. There was a firm correlation between the highest values of inflammation indicators with the decrease in percentage of CD8 T-lymphocytes. This effect was not seen with CD4 cells. Obesity together with lymphopenia, especially whether preferentially affects to CD8 T- lymphocytes, are factors that can predict a poor prognosis in patients with COVID-19. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.clim.2020.108486
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Urra&issn=1521-6616&title=Clinical+Immunology&atitle=Selective+CD8+cell+reduction+by+SARS-CoV-2+is+associated+with+a+worse+prognosis+and+systemic+inflammation+in+COVID-19+patients.&volume=217&issue=&spage=108486&epage=&date=2020&doi=10.1016%2Fj.clim.2020.108486&pmid=32479985&sid=OVID:medline
+
+<1311>
+Unique Identifier
+ 32479111
+Title
+ Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency.
+Source
+ American Journal of Respiratory & Critical Care Medicine. 202(7):973-982, 2020 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Peters MC; Mauger D; Ross KR; Phillips B; Gaston B; Cardet JC; Israel E; Levy BD; Phipatanakul W; Jarjour NN; Castro M; Wenzel SE; Hastie A; Moore W; Bleecker E; Fahy JV; Denlinger LC
+Author NameID
+ Peters, Michael C; ORCID: https://orcid.org/0000-0003-1854-4447
+Authors Full Name
+ Peters, Michael C; Mauger, David; Ross, Kristie R; Phillips, Brenda; Gaston, Benjamin; Cardet, Juan Carlos; Israel, Elliot; Levy, Bruce D; Phipatanakul, Wanda; Jarjour, Nizar N; Castro, Mario; Wenzel, Sally E; Hastie, Annette; Moore, Wendy; Bleecker, Eugene; Fahy, John V; Denlinger, Loren C.
+Institution
+ Peters, Michael C. Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.
+ Mauger, David. Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania.
+ Ross, Kristie R. University Hospitals Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, Ohio.
+ Phillips, Brenda. Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania.
+ Gaston, Benjamin. University Hospitals Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, Ohio.
+ Cardet, Juan Carlos. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida.
+ Israel, Elliot. Division of Allergy and Immunology Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Levy, Bruce D. Division of Allergy and Immunology Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Phipatanakul, Wanda. Division of Allergy and Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
+ Jarjour, Nizar N. Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin.
+ Castro, Mario. Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, Kansas.
+ Wenzel, Sally E. Department of Environmental and Occupational Health, Graduate School of Public Health University of Pittsburgh, Pittsburgh, Pennsylvania.
+ Wenzel, Sally E. Pulmonary, Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
+ Hastie, Annette. Section on Pulmonary, Critical Care, Allergy & Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
+ Moore, Wendy. Section on Pulmonary, Critical Care, Allergy & Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
+ Bleecker, Eugene. Asthma and Airway Disease Research Center and Division of Genetics, Genomics and Precision Medicine, Department of Medicine, The University of Arizona Health Sciences, Tucson, Arizona.
+ Fahy, John V. Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.
+ Fahy, John V. Cardiovascular Research Institute, University of California San Francisco, San Francisco, California.
+ Denlinger, Loren C. Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ *Asthma/bl [Blood]
+ Asthma/ep [Epidemiology]
+ Asthma/pp [Physiopathology]
+ Biomarkers
+ Comorbidity
+ Diabetes Mellitus/ep [Epidemiology]
+ *Eosinophils
+ Female
+ Forced Expiratory Volume
+ Humans
+ Hypertension/ep [Epidemiology]
+ Inflammation/bl [Blood]
+ *Interleukin-6/bl [Blood]
+ Leukocyte Count
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Phenotype
+ Symptom Flare Up
+Keyword Heading
+ IL-6
+ exacerbation-prone asthma
+ metabolic dysfunction
+ obesity
+ type-2 inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Rationale: Cross-sectional studies suggest an exacerbation-prone asthma (EPA) phenotype and the utility of blood eosinophils and plasma IL-6 as predictive biomarkers. Objectives: To prospectively test for EPA phenotype and utility of baseline blood measures of eosinophils and IL-6 as predictive biomarkers. Methods: Three-year asthma exacerbation data were analyzed in 406 adults in the Severe Asthma Research Program-3. Transition models were used to assess uninformed and informed probabilities of exacerbation in year 3. Binomial regression models were used to assess eosinophils and IL-6 as predictive biomarkers. Measurements and Main Results: Eighty-three participants (21%) had >=1 exacerbation in each year (EPA) and 168 participants (41%) had no exacerbation in any year (exacerbation-resistant asthma). The uninformed probability of an exacerbation in Year 3 was 40%, but the informed probability increased to 63% with an exacerbation in Year 2 and 82% with an exacerbation in Years 1 and 2. The probability of a Year 3 exacerbation with no Year 1 or 2 exacerbations was 13%. Compared with exacerbation-resistant asthma, EPA was characterized by lower FEV1 and a higher prevalence of obesity, hypertension, and diabetes. High-plasma IL-6 occurred in EPA, and the incident rate ratio for exacerbation increased 10% for each 1-pg/mul increase in baseline IL-6 level. Although high blood eosinophils did not occur in EPA, the incident rate ratio for exacerbations increased 9% for each 100-cell/mul increase in baseline eosinophil number. Conclusions: Longitudinal analysis confirms an EPA phenotype characterized by features of metabolic dysfunction. Blood measures of IL-6, but not eosinophils, were significantly associated with EPA, and IL-6 and eosinophils predicted exacerbations in the sample as a whole.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IL6 protein, human). 0 (Interleukin-6).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1164%2frccm.201909-1813OC
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Peters&issn=1073-449X&title=American+Journal+of+Respiratory+%26+Critical+Care+Medicine&atitle=Evidence+for+Exacerbation-Prone+Asthma+and+Predictive+Biomarkers+of+Exacerbation+Frequency.&volume=202&issue=7&spage=973&epage=982&date=2020&doi=10.1164%2Frccm.201909-1813OC&pmid=32479111&sid=OVID:medline
+
+<1312>
+Unique Identifier
+ 32472095
+Title
+ Modulation of inter-organ signalling in obese mice by spontaneous physical activity during mammary cancer development.
+Source
+ Scientific Reports. 10(1):8794, 2020 05 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Le Guennec D; Hatte V; Farges MC; Rouge S; Goepp M; Caldefie-Chezet F; Vasson MP; Rossary A
+Authors Full Name
+ Le Guennec, Delphine; Hatte, Victor; Farges, Marie-Chantal; Rouge, Stephanie; Goepp, Marie; Caldefie-Chezet, Florence; Vasson, Marie- Paule; Rossary, Adrien.
+Institution
+ Le Guennec, Delphine. Universite Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France. Delphine.le_guennec@uca.fr.
+ Hatte, Victor. Universite Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France.
+ Farges, Marie-Chantal. Universite Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France.
+ Rouge, Stephanie. Universite Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France.
+ Goepp, Marie. Universite Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France.
+ Goepp, Marie. University of Edinburgh Medical School, Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
+ Caldefie-Chezet, Florence. Universite Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France.
+ Vasson, Marie- Paule. Universite Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France.
+ Rossary, Adrien. Universite Clermont Auvergne, INRAE, UNH, F-63000, Clermont-Ferrand, France.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Animals
+ *Biomarkers/bl [Blood]
+ Breast Neoplasms/me [Metabolism]
+ Breast Neoplasms/pa [Pathology]
+ *Breast Neoplasms/rh [Rehabilitation]
+ Cell Line, Tumor
+ Disease Models, Animal
+ *Exercise Therapy/mt [Methods]
+ Female
+ Hepatocyte Growth Factor/bl [Blood]
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ Neoplasm Transplantation
+ Obesity/ci [Chemically Induced]
+ Obesity/me [Metabolism]
+ *Obesity/rh [Rehabilitation]
+ Ovariectomy
+ Signal Transduction
+ Tumor Microenvironment
+Abstract
+ Accumulative evidence links breast cancer development to excess weight and obesity. During obesity, dysregulations of adipose tissue induce an increase in pro-inflammatory adipokine secretions, such as leptin and oestrogen secretions. Furthermore, a raise in oxidative stress, along with a decrease in antioxidant capacity, induces and maintains chronic inflammation, which creates a permissive environment for cancer development. Physical activity is recommended as a non-pharmacological therapy in both obese and cancer situations. Physical activity is associated with a moderation of acute inflammation, higher antioxidant defences and adipokine regulation, linked to a decrease of tumour-cell proliferation. However, the biological mechanisms underlying the relationship between oxidative stress, low-grade inflammation, carcinogenesis, obesity and physical activity are poorly understood. Our study is based on old, ovariectomised mice (C57BL/6J mice, 33 weeks old), fed with a high fat diet which increases adipose tissue favouring overweight and obesity, and housed in either an enriched environment, promoting physical activity and social interactions, or a standard environment constituting close to sedentary conditions. Our model of mammary carcinogenesis allowed for the exploration of tissue secretions and signalling pathway activation as well as the oxidative status in tumours to clarify the mechanisms involved in a multiple factorial analysis of the data set. The multiple factorial analysis demonstrated that the most important variables linked to moderate, spontaneous physical activity were the increase in growth factor (epithelial growth factor (EGF), hepatocyte growth factor (HGF)) and the activation of the signalling pathways (STAT3, c-jun n-terminal kinases (JNK), EKR1/2, nuclear factor-kappa B (NF-kappaB)) in the gastrocnemius (G). In inguinal adipose tissue, the NF-kappaB inflammation pathway was activated, increasing the IL-6 content. The adiponectin plasma (P) level increased and presented an inverse correlation with tumour oxidative status. Altogether, these results demonstrated that spontaneous physical activity in obesity conditions could slow down tumour growth through crosstalk between muscle, adipose tissue and tumour. A spontaneous moderate physical activity was able to modify the inter-organ exchange in a paracrine manner. The different tissues changed their signalling pathways and adipokine/cytokine secretions, such as adiponectin and leptin, resulting in a decrease in anti-oxidative response and inflammation in the tumour environment. This model showed that moderate, spontaneous physical activity suppresses tumour growth via a dialogue between the organs close to the tumour.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (HGF protein, mouse). 67256-21-7 (Hepatocyte Growth Factor).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-65131-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Le+Guennec&issn=2045-2322&title=Scientific+Reports&atitle=Modulation+of+inter-organ+signalling+in+obese+mice+by+spontaneous+physical+activity+during+mammary+cancer+development.&volume=10&issue=1&spage=8794&epage=&date=2020&doi=10.1038%2Fs41598-020-65131-9&pmid=32472095&sid=OVID:medline
+
+<1313>
+Unique Identifier
+ 32469237
+Title
+ Cell-free DNA as an obesity biomarker.
+Source
+ Physiological Research. 69(3):515-520, 2020 07 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Camuzi Zovico PV; Gasparini Neto VH; Venancio FA; Soares Miguel GP; Graca Pedrosa R; Kenji Haraguchi F; Barauna VG
+Authors Full Name
+ Camuzi Zovico, P V; Gasparini Neto, V H; Venancio, F A; Soares Miguel, G P; Graca Pedrosa, R; Kenji Haraguchi, F; Barauna, V G.
+Institution
+ Camuzi Zovico, P V. Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Brazil. valerio.barauna@ufes.com.br.
+MeSH Subject Headings
+ Adult
+ Anthropometry/mt [Methods]
+ *Bariatric Surgery/mt [Methods]
+ Biomarkers/bl [Blood]
+ *C-Reactive Protein/an [Analysis]
+ *Cell-Free Nucleic Acids/bl [Blood]
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ge [Genetics]
+ Obesity/su [Surgery]
+Abstract
+ Obesity is a disease that affects about 13 % of the world population (2016) (Who 2018). This condition generates a process of systemic inflammation that may contribute to the release of cell-free DNA (cfDNA) into the bloodstream. cfDNA has been considered a potential biomarker to monitor several physiological and pathological conditions, such as tumors, exercise intensity and obesity. Therefore, the objective of this study was to evaluate the association of cfDNA levels with the amount of weight and fat mass lost six months after bariatric surgery. Thirty-eight subjects classified as obese (BMI, 43.5+/-6.2; BFP, 46.6+/-4.8) were evaluated anthropometrically and underwent bariatric surgery. Weight, BMI, body fat percentage (BFP), waist circumference, C-Reactive Protein (CRP) and cfDNA levels were evaluated before and six months after surgery; furthermore, a correlation was performed between cfDNA levels and BFP and CRP. Decrease in total body weight and CRP were observed after bariatric surgery; however, the cfDNA levels remained unchanged. There was a weak correlation between cfDNA levels and BFP before the bariatric surgery, and a moderate correlation between cfDNA and CRP. Obese subjects who underwent bariatric surgery, the decrease in body fat percentage did not result in changes in cfDNA levels six months after surgery.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cell-Free Nucleic Acids). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.33549%2fphysiolres.934242
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Camuzi+Zovico&issn=0862-8408&title=Physiological+Research&atitle=Cell-free+DNA+as+an+obesity+biomarker.&volume=69&issue=3&spage=515&epage=520&date=2020&doi=10.33549%2Fphysiolres.934242&pmid=32469237&sid=OVID:medline
+
+<1314>
+Unique Identifier
+ 32464183
+Title
+ Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents.
+Source
+ Free Radical Biology & Medicine. 155:81-86, 2020 08 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jors A; Lund MAV; Jespersen T; Hansen T; Poulsen HE; Holm JC
+Authors Full Name
+ Jors, Anna; Lund, Morten A V; Jespersen, Thomas; Hansen, Torben; Poulsen, Henrik E; Holm, Jens-Christian.
+Institution
+ Jors, Anna. The Children's Obesity Clinic, European Centre of Management (EASO), Department of Pediatrics, Copenhagen University Hospital Holbaek, Holbaek, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Lund, Morten A V. The Children's Obesity Clinic, European Centre of Management (EASO), Department of Pediatrics, Copenhagen University Hospital Holbaek, Holbaek, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: mtlu@regionsjaelland.dk.
+ Jespersen, Thomas. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Hansen, Torben. The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
+ Poulsen, Henrik E. Department of Clinical Pharmacology, Bispebjerg Frederiksberg Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Holm, Jens-Christian. The Children's Obesity Clinic, European Centre of Management (EASO), Department of Pediatrics, Copenhagen University Hospital Holbaek, Holbaek, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers
+ Child
+ Denmark
+ Deoxyguanosine
+ *Diabetes Mellitus, Type 2
+ Female
+ Humans
+ *Insulin Resistance
+ *Nucleic Acids
+ Obesity/ep [Epidemiology]
+ Oxidative Stress
+Keyword Heading
+ 8-oxoGuo
+ 8-oxodG
+ Cardiometabolic risk factors
+ Childhood obesity
+ Insulin resistance
+ Oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Oxidative stress may play an important role in childhood obesity and increased cardiometabolic risk. 8-oxo-7,8-dihydroguanosine (8-oxoGuo) from oxidation of RNA and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) from oxidation of DNA are excreted into urine and function as biomarkers for oxidative stress reflecting the modification rate of nucleic acids by oxidation. This study investigates the associations between urinary markers of nucleic acid oxidation and Body Mass Index (BMI), age, sex and cardiometabolic risk factors in children and adolescents with and without obesity.
+
+ METHODS: We studied 543 children and adolescents from an obesity clinic cohort (n = 418) and a population-based cohort (n = 125), all aged 6-18 years. Anthropometrics, urine and blood samples were collected. A validated liquid chromatography-tandem mass spectrometry method was used to measure the nucleic acid oxidation markers.
+
+ RESULTS: Compared with the population-based cohort, children and adolescents in the obesity clinic cohort had higher calculated 24-h excretion of 8-oxoGuo (p = 0.045) and 8-oxodG (p = 0.014) adjusted for basal metabolic rate. Both oxidation markers were positively associated with age and female sex (all p < 0.002). In the obesity clinic cohort the RNA oxidation marker 8-oxoGuo correlated with serum insulin (rho = 0.18, p = <.001) and insulin resistance (rho = 0.19, p = <.001).
+
+ CONCLUSIONS: Childhood obesity associate with higher urinary excretion of nucleic acid oxidation biomarkers, and increase with age throughout childhood, mirroring the obesity- and age-related increase shown in adults. Finally, children with obesity and insulin resistance had higher RNA oxidation markers than children with obesity and no insulin resistance, supporting a possible link between oxidative stress and the pathogenesis of cardiometabolic risk including type 2 diabetes. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Nucleic Acids). G9481N71RO (Deoxyguanosine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.freeradbiomed.2020.05.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jors&issn=0891-5849&title=Free+Radical+Biology+%26+Medicine&atitle=Urinary+markers+of+nucleic+acid+oxidation+increase+with+age%2C+obesity+and+insulin+resistance+in+Danish+children+and+adolescents.&volume=155&issue=&spage=81&epage=86&date=2020&doi=10.1016%2Fj.freeradbiomed.2020.05.009&pmid=32464183&sid=OVID:medline
+
+<1315>
+Unique Identifier
+ 32460579
+Title
+ Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity.
+Source
+ Arteriosclerosis, Thrombosis & Vascular Biology. 40(7):1787-1800, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ter Horst R; van den Munckhof ICL; Schraa K; Aguirre-Gamboa R; Jaeger M; Smeekens SP; Brand T; Lemmers H; Dijkstra H; Galesloot TE; de Graaf J; Xavier RJ; Li Y; Joosten LAB; Rutten JHW; Netea MG; Riksen NP
+Authors Full Name
+ Ter Horst, Rob; van den Munckhof, Inge C L; Schraa, Kiki; Aguirre-Gamboa, Raul; Jaeger, Martin; Smeekens, Sanne P; Brand, Tessa; Lemmers, Heidi; Dijkstra, Helga; Galesloot, Tessel E; de Graaf, Jacqueline; Xavier, Ramnik J; Li, Yang; Joosten, Leo A B; Rutten, Joost H W; Netea, Mihai G; Riksen, Niels P.
+Institution
+ Ter Horst, Rob. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ van den Munckhof, Inge C L. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Schraa, Kiki. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Aguirre-Gamboa, Raul. Department of Genetics, University of Groningen, University Medical Center Groningen, the Netherlands (R.A.-G.).
+ Jaeger, Martin. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Smeekens, Sanne P. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Brand, Tessa. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Lemmers, Heidi. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Dijkstra, Helga. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Galesloot, Tessel E. Department for Health Evidence, Radboud Institute for Health Sciences (T.E.G.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ de Graaf, Jacqueline. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Xavier, Ramnik J. Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston (R.J.X.).
+ Li, Yang. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands (Y.L.).
+ Li, Yang. Department of Computational Biology for Individualized Infection Medicine, Centre for Individualized Infection Medicine (CiiM) & TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Germany (Y.L.).
+ Joosten, Leo A B. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Joosten, Leo A B. Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania (L.A.B.J.).
+ Rutten, Joost H W. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Netea, Mihai G. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+ Netea, Mihai G. Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Germany (M.G.N.).
+ Riksen, Niels P. From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cells, Cultured
+ Female
+ *Health Status Disparities
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/di [Diagnosis]
+ *Inflammation/et [Etiology]
+ *Inflammation Mediators/bl [Blood]
+ Interleukin-6/bl [Blood]
+ Leptin/bl [Blood]
+ Leukocytes, Mononuclear/me [Metabolism]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/et [Etiology]
+ Metabolomics
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Risk Factors
+ Sex Factors
+Keyword Heading
+ cardiovascular disease
+ cytokines
+ inflammation
+ lipidomics
+ metabolic syndrome
+ obesity
+ sex
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Metabolic dysregulation and inflammation are important consequences of obesity and impact susceptibility to cardiovascular disease. Anti-inflammatory therapy in cardiovascular disease is being developed under the assumption that inflammatory pathways are identical in women and men, but it is not known if this is indeed the case. In this study, we assessed the sex-specific relation between inflammation and metabolic dysregulation in obesity. Approach and Results: Three hundred two individuals were included, half with a BMI 27 to 30 kg/m2 and half with a BMI>30 kg/m2, 45% were women. The presence of metabolic syndrome was assessed according to the National Cholesterol Education Program-ATPIII criteria, and inflammation was studied using circulating markers of inflammation, cell counts, and ex vivo cytokine production capacity of isolated immune cells. Additionally, lipidomic and metabolomic data were gathered, and subcutaneous fat biopsies were histologically assessed. Metabolic syndrome is associated with an increased inflammatory profile that profoundly differs between women and men: women with metabolic syndrome show a lower concentration of the anti-inflammatory adiponectin, whereas men show increased levels of several pro-inflammatory markers such as IL (interleukin)-6 and leptin. Adipose tissue inflammation showed similar sex-specific associations with these markers. Peripheral blood mononuclear cells isolated from men, but not women, with metabolic syndrome display enhanced cytokine production capacity.
+
+ CONCLUSIONS: We identified sex-specific pathways that influence inflammation in obesity. Excessive production of proinflammatory cytokines was observed in men with metabolic syndrome. In contrast, women typically showed reduced levels of the anti-inflammatory adipokine adiponectin. These different mechanisms of inflammatory dysregulation between women and men with obesity argue for sex-specific therapeutic strategies.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (IL6 protein, human). 0 (Inflammation Mediators). 0 (Interleukin-6). 0 (LEP protein, human). 0 (Leptin).
+Publication Type
+ Comparative Study. Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1161%2fATVBAHA.120.314508
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ter+Horst&issn=1079-5642&title=Arteriosclerosis%2C+Thrombosis+%26+Vascular+Biology&atitle=Sex-Specific+Regulation+of+Inflammation+and+Metabolic+Syndrome+in+Obesity.&volume=40&issue=7&spage=1787&epage=1800&date=2020&doi=10.1161%2FATVBAHA.120.314508&pmid=32460579&sid=OVID:medline
+
+<1316>
+Unique Identifier
+ 32458441
+Title
+ The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives. [Review]
+Source
+ Journal of Cellular & Molecular Medicine. 24(14):7706-7716, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Quoc Lam B; Shrivastava SK; Shrivastava A; Shankar S; Srivastava RK
+Author NameID
+ Shankar, Sharmila; ORCID: https://orcid.org/0000-0002-2854-3678
+ Srivastava, Rakesh K; ORCID: https://orcid.org/0000-0003-3112-4252
+Authors Full Name
+ Quoc Lam, Bao; Shrivastava, Sushant K; Shrivastava, Anju; Shankar, Sharmila; Srivastava, Rakesh K.
+Institution
+ Quoc Lam, Bao. Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
+ Shrivastava, Sushant K. Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi, UP, India.
+ Shrivastava, Anju. Department of Oncology, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
+ Shankar, Sharmila. Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
+ Shankar, Sharmila. Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
+ Shankar, Sharmila. Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA.
+ Srivastava, Rakesh K. Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
+ Srivastava, Rakesh K. Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Cellular Microenvironment/im [Immunology]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Disease Management
+ *Disease Susceptibility
+ Humans
+ Hypoglycemic Agents/pd [Pharmacology]
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Mutation
+ *Obesity/co [Complications]
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ *Pancreatic Neoplasms/et [Etiology]
+ Pancreatic Neoplasms/me [Metabolism]
+ Pancreatic Neoplasms/pa [Pathology]
+ Pancreatic Neoplasms/pc [Prevention & Control]
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ alcoholism
+ diabetes mellitus
+ obesity
+ pancreatic cancers
+ prevention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause of cancer-related death in the United States. The relationship among obesity, T2DM and PC is complex. Due to increase in obesity, diabetes, alcohol consumption and sedentary lifestyle, the mortality due to PC is expected to rise significantly by year 2040. The underlying mechanisms by which diabetes and obesity contribute to pancreatic tumorigenesis are not well understood. Furthermore, metabolism and microenvironment within the pancreas can also modulate pancreatic carcinogenesis. The risk of PC on a population level may be reduced by modifiable lifestyle risk factors. In this review, the interactions of diabetes and obesity to PC development were summarized, and novel strategies for the prevention and treatment of diabetes and PC were discussed. Copyright © 2020 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hypoglycemic Agents).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fjcmm.15413
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Quoc+Lam&issn=1582-1838&title=Journal+of+Cellular+%26+Molecular+Medicine&atitle=The+Impact+of+obesity+and+diabetes+mellitus+on+pancreatic+cancer%3A+Molecular+mechanisms+and+clinical+perspectives.&volume=24&issue=14&spage=7706&epage=7716&date=2020&doi=10.1111%2Fjcmm.15413&pmid=32458441&sid=OVID:medline
+
+<1317>
+Unique Identifier
+ 32456038
+Title
+ Diet and Nutrition Status of Mongolian Adults.
+Source
+ Nutrients. 12(5), 2020 May 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bromage S; Daria T; Lander RL; Tsolmon S; Houghton LA; Tserennadmid E; Gombo N; Gibson RS; Ganmaa D
+Authors Full Name
+ Bromage, Sabri; Daria, Tselmen; Lander, Rebecca L; Tsolmon, Soninkhishig; Houghton, Lisa A; Tserennadmid, Enkhjargal; Gombo, Nyamjargal; Gibson, Rosalind S; Ganmaa, Davaasambuu.
+Institution
+ Bromage, Sabri. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
+ Daria, Tselmen. Department of Neurology, Ulm University, 89081 Ulm, Germany, and Central Scientific Laboratory, Institute of Medical Sciences, Ulaanbaatar 16081, Mongolia.
+ Lander, Rebecca L. Department of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO 80045, USA.
+ Tsolmon, Soninkhishig. School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, Mongolia.
+ Houghton, Lisa A. Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand.
+ Tserennadmid, Enkhjargal. Nutrition Laboratory, National Center for Public Health, Ulaanbaatar 13381, Mongolia.
+ Gombo, Nyamjargal. Food and Agriculture Organization of the United Nations Country Office, Ulaanbaatar 14201, Mongolia.
+ Gibson, Rosalind S. Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand.
+ Ganmaa, Davaasambuu. Department of Nutrition, Harvard T.H. Chan School of Public Health and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Diet
+ Diet Records
+ *Diet Surveys
+ Dietary Fats
+ Dietary Fiber
+ Energy Intake
+ Female
+ Folic Acid
+ Food Supply
+ Food, Fortified
+ Fruit
+ Humans
+ Male
+ Micronutrients
+ Middle Aged
+ Mongolia
+ *Nutritional Status
+ Obesity
+ Vegetables
+ Vitamin B 12
+ Vitamins
+ Young Adult
+Keyword Heading
+ Mongolia
+ central Asia
+ diet survey
+ dietary pattern analysis
+ nutrient inadequacy
+ nutrition assessment
+ nutrition transition
+ nutritional epidemiology
+ overweight and obesity
+ pastoral nomadism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ (1) Background: Aspects of the Mongolian food supply, including high availability of animal-source foods and few plant foods, are plausibly associated with disease in the population. Data on Mongolian diets are lacking, and these risks are poorly quantified. The purpose of this study was to provide a multifaceted nutritional analysis of the modern Mongolian diet. (2) Methods: The study population consisted of 167 male and 167 female healthy non-pregnant urban and nomadic adults (22-55 years) randomly selected from lists of residents in 8 regions. From 2011-2016, 3-day weighed diet records and serum were collected twice from each participant in summer and winter; anthropometry was collected once from each participant. Serum was analyzed for biomarkers, and nutrient intake computed using purpose-built food composition data and adjusted for within-person variation. Exploratory dietary patterns were derived and analyzed for associations with diet and nutrition measurements. (3) Results: We collected 1838 of an expected 1986 diet records (92.5%), 610/658 serum samples (92.7%), and 315/334 height and weight measurements (94.3%). Sixty-one percent of men and 51% of women were overweight or obese. Consumption of red meat, refined grains, and whole-fat dairy was high, while that of fruits, non-tuberous vegetables, eggs, nuts and seeds, fish and poultry, and whole grains was low. Dairy and red meat were more consumed in summer and winter, respectively. Dietary inadequacy of 10 of 21 assessed nutrients, including fiber, folate, and vitamin D were >50% prevalent, while protein, zinc, and vitamin B12 inadequacy were low. Biochemical evidence of iron and vitamin A deficiency was also low. Three dietary patterns (Urban, Transitional, Nomadic) explained 41% of variation in food consumption. The Urban pattern was positively associated with BMI in multivariate analysis. (4) Conclusions: Results indicate a high prevalence of key dietary inadequacies and overweight among Mongolian adults. Prior studies by our group have suggested that expanded supplementation and food fortification would be effective in addressing micronutrient inadequacies; these strategies should be coupled with measures to mitigate the growing burden of chronic disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fats). 0 (Dietary Fiber). 0 (Micronutrients). 0 (Vitamins). 935E97BOY8 (Folic Acid). P6YC3EG204 (Vitamin B 12).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12051514
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bromage&issn=2072-6643&title=Nutrients&atitle=Diet+and+Nutrition+Status+of+Mongolian+Adults.&volume=12&issue=5&spage=&epage=&date=2020&doi=10.3390%2Fnu12051514&pmid=32456038&sid=OVID:medline
+
+<1318>
+Unique Identifier
+ 32455947
+Title
+ Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss.
+Source
+ Nutrients. 12(5), 2020 May 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Spurny M; Jiang Y; Sowah SA; Schubel R; Nonnenmacher T; Bertheau R; Kirsten R; Johnson T; Hillengass J; Schlett CL; von Stackelberg O; Ulrich CM; Kaaks R; Kauczor HU; Kuhn T; Nattenmuller J
+Author NameID
+ Hillengass, Jens; ORCID: https://orcid.org/0000-0002-1778-0010
+ Schlett, Christopher L; ORCID: https://orcid.org/0000-0002-1576-1481
+Authors Full Name
+ Spurny, Manuela; Jiang, Yixin; Sowah, Solomon A; Schubel, Ruth; Nonnenmacher, Tobias; Bertheau, Robert; Kirsten, Romy; Johnson, Theron; Hillengass, Jens; Schlett, Christopher L; von Stackelberg, Oyunbileg; Ulrich, Cornelia M; Kaaks, Rudolf; Kauczor, Hans-Ulrich; Kuhn, Tilman; Nattenmuller, Johanna.
+Institution
+ Spurny, Manuela. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
+ Jiang, Yixin. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
+ Sowah, Solomon A. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
+ Schubel, Ruth. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
+ Schubel, Ruth. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
+ Nonnenmacher, Tobias. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
+ Bertheau, Robert. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
+ Kirsten, Romy. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
+ Johnson, Theron. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
+ Hillengass, Jens. Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, New York 14263, USA.
+ Schlett, Christopher L. Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Strase 55, D-79106 Freiburg, Germany.
+ von Stackelberg, Oyunbileg. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
+ Ulrich, Cornelia M. Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112-5550, USA.
+ Kaaks, Rudolf. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
+ Kauczor, Hans-Ulrich. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
+ Kuhn, Tilman. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
+ Nattenmuller, Johanna. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adult
+ Aged
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Body Weight
+ *Bone Marrow/ch [Chemistry]
+ Bone Marrow/dg [Diagnostic Imaging]
+ *Diet, Reducing/ae [Adverse Effects]
+ *Fats/an [Analysis]
+ Female
+ Glycated Hemoglobin
+ Humans
+ Magnetic Resonance Imaging
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+ Overweight/co [Complications]
+ *Weight Loss
+Keyword Heading
+ bone marrow fat content
+ diet induced weight loss
+ magnetic resonance imaging
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Bone marrow fat is implicated in metabolism, bone health and haematological diseases. Thus, this study aims to analyse the impact of moderate weight loss on bone marrow fat content (BMFC) in obese, healthy individuals.
+
+ METHODS: Data of the HELENA-Trial (Healthy nutrition and energy restriction as cancer prevention strategies: a randomized controlled intervention trial), a randomized controlled trial (RCT) among 137 non-smoking, overweight or obese participants, were analysed to quantify the Magnetic Resonance Imaging (MRI)-derived BMFC at baseline, after a 12-week dietary intervention phase, and after a 50-week follow-up. The study cohort was classified into quartiles based on changes in body weight between baseline and week 12. Changes in BMFC in respect of weight loss were analysed by linear mixed models. Spearman's coefficients were used to assess correlations between anthropometric parameters, blood biochemical markers, blood cells and BMFC.
+
+ RESULTS: Relative changes in BMFC from baseline to week 12 were 0.0 +/- 0.2%, -3.2 +/- 0.1%, -6.1 +/- 0.2% and -11.5 +/- 0.6% for Q1 to Q4. Across all four quartiles and for the two-group comparison, Q1 versus Q4, there was a significant difference (p < 0.05) for changes in BMFC. BMFC was not associated with blood cell counts and showed only weaker correlations (<0.3) with metabolic biomarkers.
+
+ CONCLUSION: Weight loss is associated with a decrease of BMFC. However, BMFC showed no stronger associations with inflammatory and metabolic biomarkers.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fats). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12051509
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Spurny&issn=2072-6643&title=Nutrients&atitle=Changes+in+Bone+Marrow+Fat+upon+Dietary-Induced+Weight+Loss.&volume=12&issue=5&spage=&epage=&date=2020&doi=10.3390%2Fnu12051509&pmid=32455947&sid=OVID:medline
+
+<1319>
+Unique Identifier
+ 32449283
+Title
+ Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population-based study.
+Source
+ Journal of Diabetes Investigation. 11(6):1583-1593, 2020 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee YB; Kim DH; Kim SM; Kim NH; Choi KM; Baik SH; Park YG; Han K; Yoo HJ
+Author NameID
+ Yoo, Hye Jin; ORCID: https://orcid.org/0000-0003-0600-0266
+Authors Full Name
+ Lee, You-Bin; Kim, Da Hye; Kim, Seon Mee; Kim, Nan Hee; Choi, Kyung Mook; Baik, Sei Hyun; Park, Yong Gyu; Han, Kyungdo; Yoo, Hye Jin.
+Institution
+ Lee, You-Bin. Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
+ Kim, Da Hye. Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
+ Kim, Seon Mee. Department of Family Medicine, Korea University College of Medicine, Seoul, Korea.
+ Kim, Nan Hee. Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
+ Choi, Kyung Mook. Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
+ Baik, Sei Hyun. Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
+ Park, Yong Gyu. Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
+ Han, Kyungdo. Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
+ Yoo, Hye Jin. Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ Longitudinal Studies
+ Male
+ *Metabolic Syndrome/co [Complications]
+ Middle Aged
+ *Obesity/co [Complications]
+ Prognosis
+ Republic of Korea/ep [Epidemiology]
+ Retrospective Studies
+ Risk Factors
+Keyword Heading
+ Metabolic syndrome
+ Obesity
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: We investigated the risk of incident type 2 diabetes according to the cumulative exposure to obesity or metabolic syndrome (MetS) during annual or biennial health examinations.
+
+ MATERIALS AND METHODS: The Korean National Health Insurance Service datasets from 2002 to 2017 were used for this retrospective longitudinal study. The risk for type 2 diabetes was analyzed according to the cumulative exposure to obesity and MetS among individuals who underwent four health examinations from 2009 to 2012 or 2013 (n = 2,851,745).
+
+ RESULTS: During examinations, 28.56 and 17.86% of the total participants showed fluctuations in metabolic health state and obesity, respectively. During a mean 5.01 years of follow up, 98,950 new type 2 diabetes cases developed. The risk for type 2 diabetes increased with the increase in exposure to MetS (hazard ratio [HR] 2.92, 95% confidence interval [CI] 2.86-2.99; HR 4.96, 95% CI 4.85-5.08; HR 7.46, 95% CI 7.30-7.63; HR 12.24, 95% CI 12.00-12.49 in groups with number of exposures one to four, respectively) and obesity (HR 1.60, 95% CI 1.56-1.65; HR 1.87, 95% CI 1.81-1.92; HR 2.25, 95% CI 2.19-2.31; HR 3.46, 95% CI 3.41-3.51 in groups with number of exposures one to four, respectively), showing a more detrimental effect of cumulative exposure to MetS, when compared with the exposure to obesity.
+
+ CONCLUSIONS: Metabolic health and obesity fluctuated within a relatively short period of 4-5 years. Although the impact was much greater for MetS than for obesity, the cumulative duration of both obesity and MetS was associated with an increased risk of type 2 diabetes in a dose-response manner. Therefore, continuously maintaining metabolic health and normal weight is crucial to prevent incident type 2 diabetes. Copyright © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fjdi.13304
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Risk+of+type+2+diabetes+according+to+the+cumulative+exposure+to+metabolic+syndrome+or+obesity%3A+A+nationwide+population-based+study.&volume=11&issue=6&spage=1583&epage=1593&date=2020&doi=10.1111%2Fjdi.13304&pmid=32449283&sid=OVID:medline
+
+<1320>
+Unique Identifier
+ 32449055
+Title
+ Decreased Serum Adiponectin Reflects Low Vitamin D, High Interleukin 6, and Poor Physical Performance in Knee Osteoarthritis.
+Source
+ Archivum Immunologiae et Therapiae Experimentalis. 68(3):16, 2020 May 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Udomsinprasert W; Manoy P; Yuktanandana P; Tanavalee A; Anomasiri W; Honsawek S
+Author NameID
+ Honsawek, Sittisak; ORCID: http://orcid.org/0000-0003-3852-9092
+Authors Full Name
+ Udomsinprasert, Wanvisa; Manoy, Pacharee; Yuktanandana, Pongsak; Tanavalee, Aree; Anomasiri, Wilai; Honsawek, Sittisak.
+Institution
+ Udomsinprasert, Wanvisa. Department of Biochemistry, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudthaya Road, Rajathevi, Bangkok, 10400, Thailand.
+ Manoy, Pacharee. School of Allied Health Sciences, University of Phayao, 19 Phahonyothin Road, Mae Ka Subdistrict, Mueang Phayao District, Phayao, 56000, Thailand.
+ Yuktanandana, Pongsak. Department of Orthopaedics, Vinai Parkpian Orthopaedic Research Center, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, 1873 Rama IV Road, Patumwan, Bangkok, 10330, Thailand.
+ Tanavalee, Aree. Department of Orthopaedics, Vinai Parkpian Orthopaedic Research Center, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, 1873 Rama IV Road, Patumwan, Bangkok, 10330, Thailand.
+ Anomasiri, Wilai. Osteoarthritis and Musculoskeleton Research Unit, Department of Biochemistry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, 1873 Rama IV Road, Patumwan, Bangkok, 10330, Thailand.
+ Honsawek, Sittisak. Department of Orthopaedics, Vinai Parkpian Orthopaedic Research Center, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, 1873 Rama IV Road, Patumwan, Bangkok, 10330, Thailand. sittisak.h@chula.ac.th.
+ Honsawek, Sittisak. Osteoarthritis and Musculoskeleton Research Unit, Department of Biochemistry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, 1873 Rama IV Road, Patumwan, Bangkok, 10330, Thailand. sittisak.h@chula.ac.th.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Aged
+ Biomarkers/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Diagnosis, Differential
+ Female
+ Humans
+ *Interleukin-6/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/me [Metabolism]
+ Osteoarthritis, Knee/di [Diagnosis]
+ *Osteoarthritis, Knee/me [Metabolism]
+ Physical Functional Performance
+ Sarcopenia/di [Diagnosis]
+ *Sarcopenia/me [Metabolism]
+ *Vitamin D/me [Metabolism]
+Keyword Heading
+ Adiponectin
+ IL-6
+ Knee osteoarthritis
+ Poor physical performance
+ Sarcopenic obesity
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a major contributor to deterioration of physical function toward sarcopenia in knee osteoarthritis (OA) due to its effect mediated through adipokines-derived molecules that have pro-/anti-inflammatory properties. This study aimed to investigate relationships of serum adiponectin, 25-hydroxyvitamin D (25(OH)D), interleukin (IL)-6, and physical performance in knee OA patients. A total of 175 knee OA patients and 52 healthy controls were recruited. Serum adiponectin, 25(OH)D, IL-6, biochemical markers, knee pain and functional scores, muscle strength, physical performance, metabolic parameters, and body composition were evaluated. Serum adiponectin levels were significantly higher in knee OA patients than that in controls, while its serum levels were significantly decreased in obese patients, especially those with sarcopenia. Furthermore, there were independent relationships of serum adiponectin with body composition parameters, knee pain scores, physical function tests, and metabolic parameters in knee OA patients. Besides, serum adiponectin levels were positively associated with 25(OH)D levels, and negatively correlated with C-reactive protein and IL-6 levels in knee OA. Additionally, low serum adiponectin could be used to distinguish knee OA patients with sarcopenic obesity from those without sarcopenic obesity. Circulating adiponectin levels may serve as a possible surrogate biomarker for exacerbated physical function in knee OA patients-particularly sarcopenic obesity.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Interleukin-6). 1406-16-2 (Vitamin D). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs00005-020-00580-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Udomsinprasert&issn=0004-069X&title=Archivum+Immunologiae+et+Therapiae+Experimentalis&atitle=Decreased+Serum+Adiponectin+Reflects+Low+Vitamin+D%2C+High+Interleukin+6%2C+and+Poor+Physical+Performance+in+Knee+Osteoarthritis.&volume=68&issue=3&spage=16&epage=&date=2020&doi=10.1007%2Fs00005-020-00580-8&pmid=32449055&sid=OVID:medline
+
+<1321>
+Unique Identifier
+ 32446928
+Title
+ Effects of stem bark aqueous extract of Fagara tessmannii Engl (Rutaceae) on cardiovascular risks related to monosodium glutamate-induced obesity in rat: In vivo and in vitro assessments.
+Source
+ Journal of Ethnopharmacology. 260:112972, 2020 Oct 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fouda YB; Ngo Lemba Tom E; Atsamo AD; Bonabe C; Dimo T
+Authors Full Name
+ Fouda, Yannick Bekono; Ngo Lemba Tom, Esther; Atsamo, Albert Donatien; Bonabe, Christian; Dimo, Theophile.
+Institution
+ Fouda, Yannick Bekono. Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. Electronic address: yannickfouda81@yahoo.com.
+ Ngo Lemba Tom, Esther. Department of Biological Sciences, Higher Teachers' Training College, University of Yaounde I, P.O. Box 47, Yaounde, Cameroon. Electronic address: esther_ngotom@yahoo.com.
+ Atsamo, Albert Donatien. Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. Electronic address: atsamoalbert@yahoo.fr.
+ Bonabe, Christian. Department of Biological Sciences, Faculty of Sciences, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon. Electronic address: bonabe_2000c@yahoo.fr.
+ Dimo, Theophile. Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. Electronic address: dimo59@yahoo.com.
+MeSH Subject Headings
+ Adiposity/de [Drug Effects]
+ Animals
+ Animals, Newborn
+ Anti-Obesity Agents/ip [Isolation & Purification]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Arterial Pressure/de [Drug Effects]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Disease Models, Animal
+ Female
+ *Hemodynamics/de [Drug Effects]
+ Hypertension/et [Etiology]
+ Hypertension/pp [Physiopathology]
+ *Hypertension/pc [Prevention & Control]
+ Insulin Resistance
+ Male
+ Obesity/bl [Blood]
+ Obesity/ci [Chemically Induced]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Plant Bark/ch [Chemistry]
+ *Plant Bark
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ Plant Stems/ch [Chemistry]
+ *Plant Stems
+ Rats, Wistar
+ Risk Assessment
+ Risk Factors
+ Sodium Glutamate
+ Vasoconstriction/de [Drug Effects]
+ Weight Loss/de [Drug Effects]
+ Zanthoxylum/ch [Chemistry]
+ *Zanthoxylum
+Keyword Heading
+ Cardiovascular diseases
+ F. tessmannii
+ Insulin resistance
+ Monosodium glutamate
+ Obesity
+ Vascular dysfunction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ ETHNOPHARMACOLOGICAL RELEVANCE: Fagara tessmannii is a shrub of the African rainforests in South-West, Centre, South and East provinces in Cameroon. It is used in traditional medicine for the treatment of tumors, swellings, inflammation, gonorrhoea, schistosomiasis, antifungal, heart diseases and as anti-hypertensive.
+
+ AIM OF THE STUDY: We investigated the potential effects of F. tessmannii on cardiovascular risk related to monosodium glutamate-induced obesity.
+
+ MATERIALS AND METHODS: Monosodium glutamate (MSG, 4 mg/g/day) was injected subcutaneously to newborn Wistar rats for the four consecutive first days of their life and on the 6th, 8th and 10th day after birth. After 21 weeks, obese rats were treated orally with F. tessmannii (100 or 200 mg/kg/day), orlistat (10 mg/kg/day) or telmisartan (10 mg/kg/day) for 6 weeks. Body weight, obesity, body mass index (BMI), Lee index, insulin sensitivity and glucose tolerance, blood pressure, lipid profile as a Coronary Risk Index (CRI), and reactivity of isolated thoracic aorta were evaluated.
+
+ RESULTS: In addition to significantly decrease body weight (17.60% and 20.34%), BMI, Lee's index, retroperitoneal fat, total adiposity, and coronary risk indicators, F. tessmannii has significantly decreased insulin resistance and hyperglycemia and high blood pressure observed in MSG-obese rats. The high contractility to phenylephrine as well as the hypersensitivity to sodium nitroprusside (a nitric oxide-donor), observed in MSG aortic rings were significantly reduced by the F. tessmannii extract. Enhanced serum Na+ and Cl- levels and decreased K+ observed in obese rats were also significantly reversed after F. tessmannii treatment.
+
+ CONCLUSIONS: F. tessmannii fights against obesity and associated cardiovascular risks by modulating production and vascular responsiveness to vasoactive factors, monitoring premature aging. F. tessmannii promotes the loss of ectopic fat and other fatty tissues, the sensitivity of the peripherical tissues to insulin, the energy expenditure and the renovascular decompression and regulates ions movement which prevents hypertension. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Plant Extracts). W81N5U6R6U (Sodium Glutamate).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.jep.2020.112972
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fouda&issn=0378-8741&title=Journal+of+Ethnopharmacology&atitle=Effects+of+stem+bark+aqueous+extract+of+Fagara+tessmannii+Engl+%28Rutaceae%29+on+cardiovascular+risks+related+to+monosodium+glutamate-induced+obesity+in+rat%3A+In+vivo+and+in+vitro+assessments.&volume=260&issue=&spage=112972&epage=&date=2020&doi=10.1016%2Fj.jep.2020.112972&pmid=32446928&sid=OVID:medline
+
+<1322>
+Unique Identifier
+ 32444692
+Title
+ Cardiac natriuretic peptides. [Review]
+Source
+ Nature Reviews Cardiology. 17(11):698-717, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Goetze JP; Bruneau BG; Ramos HR; Ogawa T; de Bold MK; de Bold AJ
+Author NameID
+ Bruneau, Benoit G; ORCID: http://orcid.org/0000-0002-0804-7597
+ Ramos, Hugo R; ORCID: http://orcid.org/0000-0001-6772-903X
+ de Bold, Mercedes Kuroski; ORCID: http://orcid.org/0000-0003-1529-0285
+ de Bold, Adolfo J; ORCID: http://orcid.org/0000-0001-8655-4976
+Authors Full Name
+ Goetze, Jens P; Bruneau, Benoit G; Ramos, Hugo R; Ogawa, Tsuneo; de Bold, Mercedes Kuroski; de Bold, Adolfo J.
+Institution
+ Goetze, Jens P. Department of Clinical Biochemistry, Rigshospitalet University Hospital, Copenhagen, Denmark.
+ Bruneau, Benoit G. Gladstone Institutes, San Francisco, CA, USA.
+ Bruneau, Benoit G. Department of Pediatrics and Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
+ Ramos, Hugo R. Division of Cardiology, Instituto Modelo de Cardiologia, Cordoba, Argentina.
+ Ramos, Hugo R. Department of Internal Medicine, Faculty of Medicine, National University of Cordoba, Cordoba, Argentina.
+ Ogawa, Tsuneo. Department of Nutrition Management, Minami Kyushu University, Miyazaki, Japan.
+ de Bold, Mercedes Kuroski. Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
+ de Bold, Mercedes Kuroski. University of Ottawa Heart Institute, Ottawa, ON, Canada.
+ de Bold, Adolfo J. Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. adebold@bell.net.
+ de Bold, Adolfo J. University of Ottawa Heart Institute, Ottawa, ON, Canada. adebold@bell.net.
+MeSH Subject Headings
+ Animals
+ Atrial Appendage/cy [Cytology]
+ Atrial Fibrillation/me [Metabolism]
+ Atrial Natriuretic Factor/ge [Genetics]
+ *Atrial Natriuretic Factor/me [Metabolism]
+ Atrial Natriuretic Factor/ph [Physiology]
+ Atrial Remodeling
+ Biomarkers/me [Metabolism]
+ Cyclic GMP/me [Metabolism]
+ Diabetes Mellitus/me [Metabolism]
+ Fibrosis
+ Gene Expression Regulation, Developmental
+ Heart Atria/cy [Cytology]
+ *Heart Failure/me [Metabolism]
+ Humans
+ Hypertension/me [Metabolism]
+ Lipid Metabolism/ph [Physiology]
+ Metabolic Syndrome/me [Metabolism]
+ Mice
+ Myocardium/me [Metabolism]
+ Myocardium/pa [Pathology]
+ *Myocytes, Cardiac/me [Metabolism]
+ Natriuretic Peptide, Brain/ge [Genetics]
+ *Natriuretic Peptide, Brain/me [Metabolism]
+ Natriuretic Peptide, Brain/ph [Physiology]
+ Obesity/me [Metabolism]
+ Peptide Fragments/me [Metabolism]
+ Prognosis
+ Protein Processing, Post-Translational
+ Pulmonary Arterial Hypertension/me [Metabolism]
+ *Receptors, Guanylate Cyclase-Coupled/me [Metabolism]
+ Secretory Vesicles/me [Metabolism]
+ Ventricular Remodeling
+ Water-Electrolyte Balance/ph [Physiology]
+Abstract
+ Investigations into the mixed muscle-secretory phenotype of cardiomyocytes from the atrial appendages of the heart led to the discovery that these cells produce, in a regulated manner, two polypeptide hormones - the natriuretic peptides - referred to as atrial natriuretic factor or atrial natriuretic peptide (ANP) and brain or B-type natriuretic peptide (BNP), thereby demonstrating an endocrine function for the heart. Studies on the gene encoding ANP (NPPA) initiated the field of modern research into gene regulation in the cardiovascular system. Additionally, ANP and BNP were found to be the natural ligands for cell membrane-bound guanylyl cyclase receptors that mediate the effects of natriuretic peptides through the generation of intracellular cGMP, which interacts with specific enzymes and ion channels. Natriuretic peptides have many physiological actions and participate in numerous pathophysiological processes. Important clinical entities associated with natriuretic peptide research include heart failure, obesity and systemic hypertension. Plasma levels of natriuretic peptides have proven to be powerful diagnostic and prognostic biomarkers of heart disease. Development of pharmacological agents that are based on natriuretic peptides is an area of active research, with vast potential benefits for the treatment of cardiovascular disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (midregional pro-atrial natriuretic peptide, human). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain). 85637-73-6 (Atrial Natriuretic Factor). EC 4-6-1-2 (Receptors, Guanylate Cyclase-Coupled). H2D2X058MU (Cyclic GMP).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41569-020-0381-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Goetze&issn=1759-5002&title=Nature+Reviews+Cardiology&atitle=Cardiac+natriuretic+peptides.&volume=17&issue=11&spage=698&epage=717&date=2020&doi=10.1038%2Fs41569-020-0381-0&pmid=32444692&sid=OVID:medline
+
+<1323>
+Unique Identifier
+ 32442661
+Title
+ Nuclear-mitochondrial communication involving miR-181c plays an important role in cardiac dysfunction during obesity.
+Source
+ Journal of Molecular & Cellular Cardiology. 144:87-96, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Roman B; Kaur P; Ashok D; Kohr M; Biswas R; O'Rourke B; Steenbergen C; Das S
+Authors Full Name
+ Roman, Barbara; Kaur, Pawandeep; Ashok, Deepthi; Kohr, Mark; Biswas, Roopa; O'Rourke, Brian; Steenbergen, Charles; Das, Samarjit.
+Institution
+ Roman, Barbara. Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
+ Kaur, Pawandeep. Department of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
+ Ashok, Deepthi. Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
+ Kohr, Mark. Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
+ Biswas, Roopa. Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
+ O'Rourke, Brian. Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
+ Steenbergen, Charles. Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America. Electronic address: csteenb1@jhmi.edu.
+ Das, Samarjit. Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America; Department of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States of America. Electronic address: sdas11@jhmi.edu.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Calcium/me [Metabolism]
+ Calcium-Binding Proteins/ge [Genetics]
+ Calcium-Binding Proteins/me [Metabolism]
+ Cardiomegaly/et [Etiology]
+ Cardiomegaly/me [Metabolism]
+ Cardiomegaly/pp [Physiopathology]
+ *Cell Nucleus/me [Metabolism]
+ Diet, High-Fat
+ Disease Models, Animal
+ Disease Susceptibility
+ Gene Expression Regulation
+ Heart Failure/et [Etiology]
+ Heart Failure/me [Metabolism]
+ Heart Failure/pp [Physiopathology]
+ Mice
+ Mice, Knockout
+ *MicroRNAs/ge [Genetics]
+ *Mitochondria, Heart/me [Metabolism]
+ Mitochondrial Membrane Transport Proteins/ge [Genetics]
+ Mitochondrial Membrane Transport Proteins/me [Metabolism]
+ Myocytes, Cardiac/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ Oxidation-Reduction
+ Reactive Oxygen Species/me [Metabolism]
+ Sp1 Transcription Factor/me [Metabolism]
+ *Ventricular Dysfunction/et [Etiology]
+ *Ventricular Dysfunction/me [Metabolism]
+ Ventricular Dysfunction/pp [Physiopathology]
+Keyword Heading
+ MICU1
+ Mitochondria
+ Mitochondrial calcium
+ Obesity
+ miR-181c
+ microRNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: In cardiomyocytes, there is microRNA (miR) in the mitochondria that originates from the nuclear genome and matures in the cytoplasm before translocating into the mitochondria. Overexpression of one such miR, miR-181c, can lead to heart failure by stimulating reactive oxygen species (ROS) production and increasing mitochondrial calcium level ([Ca2+]m). Mitochondrial calcium uptake 1 protein (MICU1), a regulatory protein in the mitochondrial calcium uniporter complex, plays an important role in regulating [Ca2+]m. Obesity results in miR-181c overexpression and a decrease in MICU1. We hypothesize that lowering miR-181c would protect against obesity-induced cardiac dysfunction.
+
+ METHODS AND RESULTS: We used an in vivo mouse model of high-fat diet (HFD) for 18 weeks and induced high lipid load in H9c2 cells with oleate-conjugated bovine serum albumin in vitro. We tested the cardioprotective role of lowering miR-181c by using miR-181c/d-/- mice (in vivo) and AntagomiR against miR-181c (in vitro). HFD significantly upregulated heart levels of miR-181c and led to cardiac hypertrophy in wild-type mice, but not in miR-181c/d-/- mice. HFD also increased ROS production and pyruvate dehydrogenase activity (a surrogate for [Ca2+]m), but the increases were alleviated in miR-181c/d-/- mice. Moreover, miR-181c/d-/- mice fed a HFD had higher levels of MICU1 than did wild-type mice fed a HFD, attenuating the rise in [Ca2+]m. Overexpression of miR-181c in neonatal ventricular cardiomyocytes (NMVM) caused increased ROS production, which oxidized transcription factor Sp1 and led to a loss of Sp1, thereby slowing MICU1 transcription. Hence, miR-181c increases [Ca2+]m through Sp1 oxidation and downregulation of MICU1, suggesting that the cardioprotective effect of miR-181c/d-/- results from inhibition of Sp1 oxidation.
+
+ CONCLUSION: This study has identified a unique nuclear-mitochondrial communication mechanism in the heart orchestrated by miR-181c. Obesity-induced overexpression of miR-181c increases [Ca2+]m via downregulation of MICU1 and leads to cardiac injury. A strategy to inhibit miR-181c in cardiomyocytes can preserve cardiac function during obesity by improving mitochondrial function. Altering miR-181c expression may provide a pharmacologic approach to improve cardiomyopathy in individuals with obesity/type 2 diabetes. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Calcium-Binding Proteins). 0 (MICU1 protein, mouse). 0 (MicroRNAs). 0 (Mitochondrial Membrane Transport Proteins). 0 (Reactive Oxygen Species). 0 (Sp1 Transcription Factor). 0 (mirn181 microRNA, mouse). SY7Q814VUP (Calcium).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.yjmcc.2020.05.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Roman&issn=0022-2828&title=Journal+of+Molecular+%26+Cellular+Cardiology&atitle=Nuclear-mitochondrial+communication+involving+miR-181c+plays+an+important+role+in+cardiac+dysfunction+during+obesity.&volume=144&issue=&spage=87&epage=96&date=2020&doi=10.1016%2Fj.yjmcc.2020.05.009&pmid=32442661&sid=OVID:medline
+
+<1324>
+Unique Identifier
+ 32439261
+Title
+ Pancreastatin inhibitor PSTi8 protects the obesity associated skeletal muscle insulin resistance in diet induced streptozotocin-treated diabetic mice.
+Source
+ European Journal of Pharmacology. 881:173204, 2020 Aug 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gupta AP; Garg R; Singh P; Goand UK; Syed AA; Valicherla GR; Riyazuddin M; Mugale MN; Gayen JR
+Authors Full Name
+ Gupta, Anand P; Garg, Richa; Singh, Pragati; Goand, Umesh K; Syed, Anees A; Valicherla, Guru R; Riyazuddin, Mohammed; Mugale, Madhav N; Gayen, Jiaur R.
+Institution
+ Gupta, Anand P. Pharmaceutics & Pharmacokinetics Division, Lucknow, 226031, India.
+ Garg, Richa. Pharmaceutics & Pharmacokinetics Division, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
+ Singh, Pragati. Pharmaceutics & Pharmacokinetics Division, Lucknow, 226031, India.
+ Goand, Umesh K. Pharmaceutics & Pharmacokinetics Division, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
+ Syed, Anees A. Pharmaceutics & Pharmacokinetics Division, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
+ Valicherla, Guru R. Pharmaceutics & Pharmacokinetics Division, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
+ Riyazuddin, Mohammed. Pharmaceutics & Pharmacokinetics Division, Lucknow, 226031, India.
+ Mugale, Madhav N. Toxicology & Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
+ Gayen, Jiaur R. Pharmaceutics & Pharmacokinetics Division, Lucknow, 226031, India; Pharmacology Division, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. Electronic address: jr.gayen@cdri.res.in.
+MeSH Subject Headings
+ Adipose Tissue, White/de [Drug Effects]
+ Adipose Tissue, White/me [Metabolism]
+ Adipose Tissue, White/pp [Physiopathology]
+ Adiposity/de [Drug Effects]
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Chromogranin A/ai [Antagonists & Inhibitors]
+ Chromogranin A/me [Metabolism]
+ Diabetes Mellitus, Experimental/ci [Chemically Induced]
+ *Diabetes Mellitus, Experimental/dt [Drug Therapy]
+ Diabetes Mellitus, Experimental/me [Metabolism]
+ Diabetes Mellitus, Experimental/pp [Physiopathology]
+ Diabetes Mellitus, Type 2/ci [Chemically Induced]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Diet, High-Fat
+ Energy Metabolism/de [Drug Effects]
+ GTPase-Activating Proteins/me [Metabolism]
+ Glucose Transporter Type 4/me [Metabolism]
+ Humans
+ *Hypoglycemic Agents/pd [Pharmacology]
+ Inflammation Mediators/me [Metabolism]
+ *Insulin Resistance
+ Macrophages/de [Drug Effects]
+ Macrophages/me [Metabolism]
+ Male
+ Mice, Inbred C57BL
+ *Muscle, Skeletal/de [Drug Effects]
+ Muscle, Skeletal/me [Metabolism]
+ Muscle, Skeletal/pp [Physiopathology]
+ Obesity/co [Complications]
+ *Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Proto-Oncogene Proteins c-akt/me [Metabolism]
+ Streptozocin
+ THP-1 Cells
+Keyword Heading
+ Diabetes
+ Inflammation
+ Insulin resistance
+ Obesity
+ PSTi8
+ Pancreastatin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pancreastatin (PST), a chromogranin A (CHGA) derived peptide connects obesity with insulin resistance by inducing inflammation. Previously, we have evaluated potential activity of PST inhibitor (PSTi8) in liver and adipose tissue in type 2 diabetic mice model. In this study we further explore the therapeutic effect of PSTi8 on glucose metabolism in skeletal muscle cells/tissue and its effect on energy homeostasis in diet induced diabetic mice model. In in-vitro studies, we found that PSTi8 increases glucose uptake via enhanced GLUT4 translocation in L6 cells. This positive effect of PSTi8 led us to proceed with in-vivo studies in diabetic mice. C57BL/6 mice were fed HFD or HFrD diet for 12 weeks along with single STZ induction at 4th week followed by PSTi8 treatment. We found that HFD and HFrD model showed increased fat mass, caused glucose intolerance and insulin resistance, with accompanying proinflammatory effect on epididymal white adipose tissue (eWAT) together leading to skeletal muscle insulin resistance. Administration of PSTi8 protects from diet induced inflammatory response and enhances glucose tolerance and insulin sensitivity. PSTi8 improves circulating adipokine and lipid parameters, along with switch in macrophage polarisation from M1 to M2 in stromal vascular fraction of adipose tissue. In addition, treatment of PSTi8 also improves energy homeostasis, decreases circulatory non-esterified fatty acids level and inhibits ceramide deposition in muscle tissue. Overall this increased muscle insulin sensitivity is mediated via AKT/AS160/GLUT4 pathway activation. Our results reveal that PSTi8 inhibits the obesity mediated inflammation which enhances glucose disposal in skeletal muscle. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Chromogranin A). 0 (GTPase-Activating Proteins). 0 (Glucose Transporter Type 4). 0 (Hypoglycemic Agents). 0 (Inflammation Mediators). 0 (Slc2a4 protein, mouse). 0 (Tbc1d4 protein, mouse). 106477-83-2 (pancreastatin). 5W494URQ81 (Streptozocin). EC 2-7-11-1 (Proto-Oncogene Proteins c-akt).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.ejphar.2020.173204
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gupta&issn=0014-2999&title=European+Journal+of+Pharmacology&atitle=Pancreastatin+inhibitor+PSTi8+protects+the+obesity+associated+skeletal+muscle+insulin+resistance+in+diet+induced+streptozotocin-treated+diabetic+mice.&volume=881&issue=&spage=173204&epage=&date=2020&doi=10.1016%2Fj.ejphar.2020.173204&pmid=32439261&sid=OVID:medline
+
+<1325>
+Unique Identifier
+ 32438689
+Title
+ The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?. [Review]
+Source
+ Nutrients. 12(5), 2020 May 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Magne F; Gotteland M; Gauthier L; Zazueta A; Pesoa S; Navarrete P; Balamurugan R
+Author NameID
+ Magne, Fabien; ORCID: https://orcid.org/0000-0002-8210-4561
+ Navarrete, Paola; ORCID: https://orcid.org/0000-0003-0692-2324
+ Balamurugan, Ramadass; ORCID: https://orcid.org/0000-0002-8158-230X
+Authors Full Name
+ Magne, Fabien; Gotteland, Martin; Gauthier, Lea; Zazueta, Alejandra; Pesoa, Susana; Navarrete, Paola; Balamurugan, Ramadass.
+Institution
+ Magne, Fabien. Microbiology and Mycology Program, ICBM, Faculty of Medicine, University of Chile, Santiago 8320000, Chile.
+ Gotteland, Martin. Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8320000, Chile.
+ Gotteland, Martin. Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7830490, Chile.
+ Gotteland, Martin. Millennium Nucleus in the Biology of Intestinal Microbiota, Santiago 7830490, Chile.
+ Gauthier, Lea. Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8320000, Chile.
+ Zazueta, Alejandra. Microbiology and Mycology Program, ICBM, Faculty of Medicine, University of Chile, Santiago 8320000, Chile.
+ Pesoa, Susana. Department of Molecular Diagnosis, LACE Laboratories, Cordoba X5000, Argentina.
+ Navarrete, Paola. Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7830490, Chile.
+ Navarrete, Paola. Millennium Nucleus in the Biology of Intestinal Microbiota, Santiago 7830490, Chile.
+ Balamurugan, Ramadass. Department of Biochemistry, AIIMS, Bhubaneswar 751019, India.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Bacteroidetes/ip [Isolation & Purification]
+ Biomarkers/an [Analysis]
+ Colony Count, Microbial
+ *Dysbiosis/di [Diagnosis]
+ Dysbiosis/mi [Microbiology]
+ Female
+ *Firmicutes/ip [Isolation & Purification]
+ *Gastrointestinal Microbiome/ge [Genetics]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/mi [Microbiology]
+ Reproducibility of Results
+ Sequence Analysis, DNA
+Keyword Heading
+ Bacteroidetes
+ Firmicutes
+ Microbiota
+ dysbiosis
+ gut
+ marker
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The gut microbiota is emerging as a promising target for the management or prevention of inflammatory and metabolic disorders in humans. Many of the current research efforts are focused on the identification of specific microbial signatures, more particularly for those associated with obesity, type 2 diabetes, and cardiovascular diseases. Some studies have described that the gut microbiota of obese animals and humans exhibits a higher Firmicutes/Bacteroidetes ratio compared with normal-weight individuals, proposing this ratio as an eventual biomarker. Accordingly, the Firmicutes/Bacteroidetes ratio is frequently cited in the scientific literature as a hallmark of obesity. The aim of the present review was to discuss the validity of this potential marker, based on the great amount of contradictory results reported in the literature. Such discrepancies might be explained by the existence of interpretative bias generated by methodological differences in sample processing and DNA sequence analysis, or by the generally poor characterization of the recruited subjects and, more particularly, the lack of consideration of lifestyle-associated factors known to affect microbiota composition and/or diversity. For these reasons, it is currently difficult to associate the Firmicutes/Bacteroidetes ratio with a determined health status and more specifically to consider it as a hallmark of obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12051474
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Magne&issn=2072-6643&title=Nutrients&atitle=The+Firmicutes%2FBacteroidetes+Ratio%3A+A+Relevant+Marker+of+Gut+Dysbiosis+in+Obese+Patients%3F.&volume=12&issue=5&spage=&epage=&date=2020&doi=10.3390%2Fnu12051474&pmid=32438689&sid=OVID:medline
+
+<1326>
+Unique Identifier
+ 32433484
+Title
+ Neck circumference is associated with adipose tissue content in thigh skeletal muscle in overweight and obese premenopausal women.
+Source
+ Scientific Reports. 10(1):8324, 2020 05 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Arias Tellez MJ; Silva AM; Ruiz JR; Martins SS; Palmeira AL; Branco TL; Minderico CS; Rocha PM; Themudo-Barata J; Teixeira PJ; Sardinha LB
+Author NameID
+ Arias Tellez, Maria Jose; ORCID: http://orcid.org/0000-0001-6738-6196
+ Ruiz, Jonatan R; ORCID: http://orcid.org/0000-0002-7548-7138
+Authors Full Name
+ Arias Tellez, Maria Jose; Silva, Analiza M; Ruiz, Jonatan R; Martins, Sandra S; Palmeira, Antonio L; Branco, Teresa L; Minderico, Claudia S; Rocha, Paulo M; Themudo-Barata, Jose; Teixeira, Pedro J; Sardinha, Luis B.
+Institution
+ Arias Tellez, Maria Jose. Department of Nutrition, Faculty of Medicine, University of Chile, Independence, 1027, Santiago, Chile. mariajosearias@uchile.cl.
+ Arias Tellez, Maria Jose. PROFITH "PROmoting FITness and Health through physical activity" research group. Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Ctra de Alfacar s/n C.P., 18071, Granada, Spain. mariajosearias@uchile.cl.
+ Silva, Analiza M. Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1495-688, Cruz Quebrada, Portugal.
+ Ruiz, Jonatan R. PROFITH "PROmoting FITness and Health through physical activity" research group. Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Ctra de Alfacar s/n C.P., 18071, Granada, Spain.
+ Martins, Sandra S. Universidade Europeia, Lisbon, Portugal.
+ Martins, Sandra S. Instituto de Saude Ambiental (ISAMB), Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
+ Palmeira, Antonio L. Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1495-688, Cruz Quebrada, Portugal.
+ Branco, Teresa L. Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1495-688, Cruz Quebrada, Portugal.
+ Minderico, Claudia S. Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1495-688, Cruz Quebrada, Portugal.
+ Rocha, Paulo M. Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1495-688, Cruz Quebrada, Portugal.
+ Themudo-Barata, Jose. Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1495-688, Cruz Quebrada, Portugal.
+ Teixeira, Pedro J. Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1495-688, Cruz Quebrada, Portugal.
+ Sardinha, Luis B. Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1495-688, Cruz Quebrada, Portugal. lsardinha@fmh.utl.pt.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Composition
+ Body Weights and Measures
+ Cross-Sectional Studies
+ Female
+ Humans
+ Intra-Abdominal Fat
+ *Muscle, Skeletal/pa [Pathology]
+ *Neck/pa [Pathology]
+ *Obesity/pa [Pathology]
+ Premenopause
+ Thigh
+ Tomography, X-Ray Computed
+Abstract
+ Neck circumference (NC) has been proposed as a simple and practical tool, independently associated with cardiometabolic risk factors. However, the association of NC with inter-muscular adipose tissue (IMAT) is still to be determined. We aimed to examine the association of NC with thigh IMAT, and visceral adipose tissue (VAT) measured with computed tomography (CT) in overweight/obese women. 142 premenopausal overweight and obese Caucasian women participated in this cross-sectional study. NC was measured with an inextensible metallic tape above the thyroid cartilage according to International Society for Advancement of Kinanthropometry protocol. Thigh IMAT and VAT volumes were measured with a single cross-sectional CT. Regarding the covariates, fat mass (FM) was assessed with dual-energy x-ray absorptiometry and physical activity was objectively measured with accelerometry. NC was positively associated with thigh IMAT and VAT volumes (standardized beta coefficient: beta = 0.45, P-value = <=0.001, beta = 0.60, P = <= 0.001; respectively), which persisted after adjusting for age, height, overall FM or moderate-to-vigorous physical activity. Our findings show that NC is associated with thigh IMAT volume in overweight and obese premenopausal Caucasian women, regardless of the amount of lower-body fatness. These results suggest underscoring the relevance of NC as a marker of adipose tissue content in thigh skeletal muscle.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-65204-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Arias+Tellez&issn=2045-2322&title=Scientific+Reports&atitle=Neck+circumference+is+associated+with+adipose+tissue+content+in+thigh+skeletal+muscle+in+overweight+and+obese+premenopausal+women.&volume=10&issue=1&spage=8324&epage=&date=2020&doi=10.1038%2Fs41598-020-65204-9&pmid=32433484&sid=OVID:medline
+
+<1327>
+Unique Identifier
+ 32423881
+Title
+ Effect of Phoenix dactylifera seeds (dates) extract in triton WR-1339 and high fat diet induced hyperlipidaemia in rats: A comparison with simvastatin.
+Source
+ Journal of Ethnopharmacology. 259:112961, 2020 Sep 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bouhlali EDT; Hmidani A; Bourkhis B; Khouya T; Harnafi H; Filali-Zegzouti Y; Alem C
+Authors Full Name
+ Bouhlali, Eimad Dine Tariq; Hmidani, Abdelbasset; Bourkhis, Bouchra; Khouya, Tarik; Harnafi, Hicham; Filali-Zegzouti, Younes; Alem, Chakib.
+Institution
+ Bouhlali, Eimad Dine Tariq. National Institute of Agronomic Research, Regional Center of Errachidia, 52000, Morocco; Biochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, 52000, Morocco. Electronic address: bouhlali.eimad@gmail.com.
+ Hmidani, Abdelbasset. Biochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, 52000, Morocco.
+ Bourkhis, Bouchra. Faculty of Medicine and Pharmacy, Fes, 30070, Morocco.
+ Khouya, Tarik. Biochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, 52000, Morocco.
+ Harnafi, Hicham. Laboratory of Biochemistry and Biotechnologies, Faculty of Sciences, Oujda, 60000, Morocco.
+ Filali-Zegzouti, Younes. Biology, Environment and Health Team, Faculty of Sciences and Techniques Errachidia, 50000, Morocco.
+ Alem, Chakib. Biochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, 52000, Morocco.
+MeSH Subject Headings
+ Animals
+ Antioxidants/ip [Isolation & Purification]
+ Antioxidants/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Diet, High-Fat
+ Disease Models, Animal
+ *Hydroxymethylglutaryl-CoA Reductase Inhibitors/pd [Pharmacology]
+ Hyperlipidemias/bl [Blood]
+ Hyperlipidemias/ci [Chemically Induced]
+ *Hyperlipidemias/pc [Prevention & Control]
+ Hypolipidemic Agents/ip [Isolation & Purification]
+ *Hypolipidemic Agents/pd [Pharmacology]
+ Lipid Peroxidation
+ *Lipids/bl [Blood]
+ Male
+ Obesity/et [Etiology]
+ Obesity/pc [Prevention & Control]
+ Phoeniceae/ch [Chemistry]
+ *Phoeniceae
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ Polyethylene Glycols/ch [Chemistry]
+ Polyphenols/ip [Isolation & Purification]
+ *Polyphenols/pd [Pharmacology]
+ Rats, Wistar
+ Seeds/ch [Chemistry]
+ *Seeds
+ *Simvastatin/pd [Pharmacology]
+ Solvents/ch [Chemistry]
+ Weight Gain/de [Drug Effects]
+Keyword Heading
+ Atherosclerosis
+ Date seeds
+ Dyslipidaemia
+ Fat diet
+ Obesity
+ Triton
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ ETHNOPHARMACOLOGICAL RELEVANCE: Date seeds are widely used in Moroccan traditional medicine for treating obesity and related diseases.
+
+ AIM OF THE STUDY: Two date seed varieties (Jihel and Majhoul) were assessed for their phenolic profile and lipid-lowering activity.
+
+ MATERIALS AND METHODS: The polyphenolic profile was determined using HPLC-DAD. Triton-WR-1339 and high-fat diet (HFD)-induced hyperlipidaemic rats were used to evaluate the hypolipidaemic effect of date seeds extracts. Serum lipid profile was measured using automatic biochemical analyser.
+
+ RESULTS: Rutin, quercetin, p-coumaric and caffeic acids were the most prevalent chemical among the analysed phenolic compounds. Serum lipids: Total cholesterol, triglycerides, low-density lipoprotein-cholesterol were lowered and high-density lipoprotein-cholesterol were increased by date seed methanolic extract (at 200 mg/kg) in triton WR1339 -induced hyperlipidaemia in experimental rats. Chronic feeding of these extracts (at 200 mg/kg), to animals concurrently fed with high fat diet (HFD) for three weeks, caused a significant (p < 0.05) decrease in serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol levels and atherogenic index, while it increased serum HDL-C. Furthermore, the supplementation of date seed extract was effective in preventing body weight gain.
+
+ CONCLUSIONS: These findings are suggestive of hypolipidaemic and atherosclerosis prevention roles of Jihel and Majhoul date seeds. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors). 0 (Hypolipidemic Agents). 0 (Lipids). 0 (Plant Extracts). 0 (Polyphenols). 0 (Solvents). 3WJQ0SDW1A (Polyethylene Glycols). AGG2FN16EV (Simvastatin). Y27PUL9H56 (tyloxapol).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.jep.2020.112961
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bouhlali&issn=0378-8741&title=Journal+of+Ethnopharmacology&atitle=Effect+of+Phoenix+dactylifera+seeds+%28dates%29+extract+in+triton+WR-1339+and+high+fat+diet+induced+hyperlipidaemia+in+rats%3A+A+comparison+with+simvastatin.&volume=259&issue=&spage=112961&epage=&date=2020&doi=10.1016%2Fj.jep.2020.112961&pmid=32423881&sid=OVID:medline
+
+<1328>
+Unique Identifier
+ 32420886
+Title
+ [The adiponectin to leptin ratio, a still unrecognized biomarker of insulin resistance and cardiometabolic risk]. [Review] [French]
+Original Title
+ Le rapport adiponectine sur leptine, un biomarqueur d'insulino-resistance et de risque cardiometabolique encore meconnu.
+Source
+ Annales de Biologie Clinique. 78(3):265-268, 2020 06 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vatier C; Antuna-Puente B; Fellahi S; Vigouroux C; Capeau J; Bastard JP
+Corporate Author
+ groupe de travail RIHN Adipokines
+Authors Full Name
+ Vatier, Camille; Antuna-Puente, Barbara; Fellahi, Soraya; Vigouroux, Corinne; Capeau, Jacqueline; Bastard, Jean-Philippe.
+Institution
+ Vatier, Camille. Sorbonne Universite, Inserm UMR_S 938, Centre de recherche Saint-Antoine, Institut hospitalo-universitaire de cardio-metabolisme et nutrition (ICAN), Paris, France, Hopital Saint-Antoine, AP-HP, Centre national de reference des pathologies rares de l'insulino-secretion et de l'insulino-sensibilite (PRISIS), Service d'endocrinologie, diabetologie et endocrinologie de la reproduction, Paris, France.
+ Antuna-Puente, Barbara. Infection Disease Division, Department of Medicine, Queen's University, Kingston, ON, Canada.
+ Fellahi, Soraya. Sorbonne Universite, Inserm UMR_S 938, Centre de recherche Saint-Antoine, Institut hospitalo-universitaire de cardio-metabolisme et nutrition (ICAN), Paris, France, Hopital Tenon, AP-HP, Service de biochimie et hormonologie, UF Bio-marqueurs inflammatoires et metaboliques, Paris, France.
+ Vigouroux, Corinne. Sorbonne Universite, Inserm UMR_S 938, Centre de recherche Saint-Antoine, Institut hospitalo-universitaire de cardio-metabolisme et nutrition (ICAN), Paris, France, Hopital Saint-Antoine, AP-HP, Centre national de reference des pathologies rares de l'insulino-secretion et de l'insulino-sensibilite (PRISIS), Service d'endocrinologie, diabetologie et endocrinologie de la reproduction, Paris, France, Hopital Saint-Antoine, AP-HP, Laboratoire commun de biologie et genetique moleculaires, Paris, France.
+ Capeau, Jacqueline. Sorbonne Universite, Inserm UMR_S 938, Centre de recherche Saint-Antoine, Institut hospitalo-universitaire de cardio-metabolisme et nutrition (ICAN), Paris, France.
+ Bastard, Jean-Philippe. Sorbonne Universite, Inserm UMR_S 938, Centre de recherche Saint-Antoine, Institut hospitalo-universitaire de cardio-metabolisme et nutrition (ICAN), Paris, France, Hopital Tenon, AP-HP, Service de biochimie et hormonologie, UF Bio-marqueurs inflammatoires et metaboliques, Paris, France, Hopitaux universitaires Henri Mondor, AP-HP, Departement de biochimie-pharmacologie-biologie moleculaire-genetique medicale, Creteil, France.
+MeSH Subject Headings
+ Adiponectin/an [Analysis]
+ *Adiponectin/bl [Blood]
+ Biomarkers/an [Analysis]
+ *Biomarkers/bl [Blood]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/et [Etiology]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diagnostic Techniques, Endocrine
+ Humans
+ *Insulin Resistance
+ Leptin/an [Analysis]
+ *Leptin/bl [Blood]
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ adiponectin
+ adiponectin/leptin ratio
+ insulin resistance
+ leptin
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Leptin and adiponectin are two adipokines. Their circulating concentrations, high for leptin and low for adiponectin, are predictive of insulin resistance and of an unfavorable cardiometabolic evolution in patients with obesity, metabolic syndrome or type 2 diabetes. In addition, recently, the adiponectin/leptin ratio has been proposed as an index of adipose tissue dysfunction together with threshold values for cardiometabolic risk for this index. The relevance and potential applications of the adiponectin/leptin and leptin/adiponectin ratios are discussed in the light of recent literature in this brief update.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1684%2fabc.2020.1559
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vatier&issn=0003-3898&title=Annales+de+Biologie+Clinique&atitle=Le+rapport+adiponectine+sur+leptine%2C+un+biomarqueur+d%27insulino-resistance+et+de+risque+cardiometabolique+encore+meconnu.&volume=78&issue=3&spage=265&epage=268&date=2020&doi=10.1684%2Fabc.2020.1559&pmid=32420886&sid=OVID:medline
+
+<1329>
+Unique Identifier
+ 32416637
+Title
+ Biochemical investigation of rs1801282 variations in PPAR-gamma gene and its correlation with risk factors of diabetes mellitus in coronary artery disease.
+Source
+ Clinical & Experimental Pharmacology & Physiology. 47(9):1517-1529, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rehman K; Jabeen K; Awan FR; Hussain M; Saddique MA; Akash MSH
+Author NameID
+ Rehman, Kanwal; ORCID: https://orcid.org/0000-0001-7873-6681
+ Akash, Muhammad Sajid Hamid; ORCID: https://orcid.org/0000-0002-9446-5233
+Authors Full Name
+ Rehman, Kanwal; Jabeen, Komal; Awan, Fazli Rabbi; Hussain, Misbah; Saddique, Muhammad Asim; Akash, Muhammad Sajid Hamid.
+Institution
+ Rehman, Kanwal. Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan.
+ Rehman, Kanwal. Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
+ Jabeen, Komal. Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
+ Awan, Fazli Rabbi. Laboratory of Human Molecular Genetics and Metabolic Disorders, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan.
+ Hussain, Misbah. Laboratory of Human Molecular Genetics and Metabolic Disorders, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan.
+ Saddique, Muhammad Asim. Department of Cardiology, District Head Quarter Teaching Hospital, Sargodha, Pakistan.
+ Akash, Muhammad Sajid Hamid. Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ Coronary Artery Disease/di [Diagnosis]
+ Coronary Artery Disease/ep [Epidemiology]
+ *Coronary Artery Disease/ge [Genetics]
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus/ge [Genetics]
+ Female
+ Genetic Association Studies
+ Genetic Predisposition to Disease
+ Humans
+ Hypertension/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ *PPAR gamma/ge [Genetics]
+ Pakistan/ep [Epidemiology]
+ Phenotype
+ *Polymorphism, Single Nucleotide
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Smoking/ae [Adverse Effects]
+ Smoking/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ ARMS-PCR
+ PPAR-gamma
+ cardiovascular diseases
+ diabetes mellitus
+ genotypes
+ rs1801282
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We aimed to investigate the association of single nucleotide polymorphism of Pro/Ala (rs1801282) in peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene with risk factors of diabetes mellitus (DM) in cardiovascular disease (CVD) patients. We recruited 244 participants from Faisalabad Institute of Cardiology and Department of Cardiology, Sargodha District Head Quarter Teaching Hospital, Pakistan. Out of 244 participants, 144 cases were CVD patients and 100 were healthy controls. CVD patients were further divided into 111 coronary artery disease (CAD) and 33 cardiomyopathy (CMP) patients. Assessment of variant specific polymorphism/mutation of Pro/Pro and Pro/Ala genotypes was done through amplification refractory mutation system polymerase chain reaction (ARMS-PCR). Further, serum biomarkers were measured to investigate the association among risk factors of DM and Pro/Ala polymorphism in PPAR-gamma gene. About 31.5% Pro/Ala genotype was found in CVD patients out of which 22.5% were CAD patients and 9% were CMP patients. As a result, obesity, hypertension and smoking (35%, 23%, 21%, respectively) were observed to be the most critical risk factors accompanying Pro/Ala mutation in PPAR-gamma particularly in CAD patients as compared to that in CMP patients. A similar pattern of association was observed among the elevated levels of glucose, cholesterol, triglyceride and ALT with Pro/Ala mutation in CAD patients. Further, CAD patients using ACE inhibitors (18%) and beta-blockers (13%) were found to be the carriers of Pro/Ala genotype and also showed significant increase in glucose level. This study suggests that hyperglycaemia in CAD patients particularly obese, smokers and hypertensives having Pro/Ala polymorphism in PPAR-gamma gene are at high risk of developing DM as clearly observed by hyperglycaemia in CAD patients. Copyright © 2020 John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (PPAR gamma). 0 (PPARG protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2f1440-1681.13339
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rehman&issn=0305-1870&title=Clinical+%26+Experimental+Pharmacology+%26+Physiology&atitle=Biochemical+investigation+of+rs1801282+variations+in+PPAR-gamma+gene+and+its+correlation+with+risk+factors+of+diabetes+mellitus+in+coronary+artery+disease.&volume=47&issue=9&spage=1517&epage=1529&date=2020&doi=10.1111%2F1440-1681.13339&pmid=32416637&sid=OVID:medline
+
+<1330>
+Unique Identifier
+ 32415755
+Title
+ Estimates of beta cell function adjusted by anthropometric markers in patients with T2DM.
+Source
+ Clinical & Experimental Pharmacology & Physiology. 47(9):1509-1516, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang M; Su Y; Quan L; Jiang S; Yao H
+Author NameID
+ Zhang, Mingchen; ORCID: https://orcid.org/0000-0002-1002-3009
+Authors Full Name
+ Zhang, Mingchen; Su, Yinxia; Quan, Li; Jiang, Sheng; Yao, Hua.
+Institution
+ Zhang, Mingchen. Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
+ Zhang, Mingchen. Postdoctoral Research Station of Public Health, School of Public Health, Xinjiang Medical University, Urumqi, China.
+ Su, Yinxia. Health Management Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
+ Quan, Li. Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
+ Jiang, Sheng. Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
+ Yao, Hua. Postdoctoral Research Station of Public Health, School of Public Health, Xinjiang Medical University, Urumqi, China.
+ Yao, Hua. The Key Laboratory of Xinjiang Metabolic Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Anthropometry
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *C-Peptide/bl [Blood]
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ *Insulin-Secreting Cells/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Pancreatic Function Tests
+ Predictive Value of Tests
+Keyword Heading
+ B cell function
+ anthropometric marker
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We sought to determine whether adjusting the indices used to assess beta cell function by anthropometric markers of obesity improves their clinical value in a diabetic population. We conducted a cross-sectional survey of 3732 diabetic patients who underwent a 100 g carbohydrate meal test. Insulin secretion was estimated using HOMA-B of steady state as well as C0-30 /G0-30 , AUCc30-120 /AUCG30-120 and CPIn for dynamic state. Body weight index, waist circumference, waist-hip ratio and body surface area were recorded. The final analysis included 2873 T2DM patients. Correlation analyses showed that there was a poor correlation between diabetic duration and CPI30 (r = -.040, P < .05), and there were no remarkable changes in the correlation coefficient after CPI30 was divided by BMI, WC, WHR, or body surface area, respectively. The same was found for the correlation between HbA1c and CPI120 with these measures. The main determinants of diabetic duration were age (beta = 0.388, P < .001), log HOMA-IR (beta = -0.328, P < .001), CPI30 (beta = -0.045, P = .011). There were no remarkable changes in beta weights between diabetic duration and CPI30 when it was corrected with anthropometric markers in the multiple stepwise linear regression analyses. The same was found between HbA1c and CPI120 . CPI30 and CPI120 are more practical indexes. Correcting the indices used to estimate the beta cell function by anthropometric markers of obesity may not improve their correlations with diabetic duration or HbA1c in a diabetic population. Copyright © 2020 John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (C-Peptide). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2f1440-1681.13337
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=0305-1870&title=Clinical+%26+Experimental+Pharmacology+%26+Physiology&atitle=Estimates+of+beta+cell+function+adjusted+by+anthropometric+markers+in+patients+with+T2DM.&volume=47&issue=9&spage=1509&epage=1516&date=2020&doi=10.1111%2F1440-1681.13337&pmid=32415755&sid=OVID:medline
+
+<1331>
+Unique Identifier
+ 32415247
+Title
+ Obesity and Diabetes in an Arab population: Role of Adenovirus 36 Infection.
+Source
+ Scientific Reports. 10(1):8107, 2020 05 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lessan N; Saradalekshmi KR; Alkaf B; Majeed M; Barakat MT; Lee ZPL; Atkinson RL
+Authors Full Name
+ Lessan, Nader; Saradalekshmi, Koramannil R; Alkaf, Budour; Majeed, Maria; Barakat, Maha T; Lee, Zendra P L; Atkinson, Richard L.
+Institution
+ Lessan, Nader. Imperial College London Diabetes Centre, Abu Dhabi, UAE. nlessan@icldc.ae.
+ Saradalekshmi, Koramannil R. Imperial College London Diabetes Centre, Abu Dhabi, UAE.
+ Alkaf, Budour. Imperial College London Diabetes Centre, Abu Dhabi, UAE.
+ Majeed, Maria. Imperial College London Diabetes Centre, Abu Dhabi, UAE.
+ Barakat, Maha T. Imperial College London Diabetes Centre, Abu Dhabi, UAE.
+ Lee, Zendra P L. Obetech Obesity Research Center, Richmond, VA, USA.
+ Atkinson, Richard L. Virginia Commonwealth University, Richmond, VA, USA.
+ Atkinson, Richard L. Obetech Obesity Research Center, Richmond, VA, USA.
+MeSH Subject Headings
+ *Adenovirus Infections, Human/co [Complications]
+ Adenovirus Infections, Human/vi [Virology]
+ *Adenoviruses, Human/ip [Isolation & Purification]
+ *Adiposity
+ Adult
+ *Arabs/sn [Statistics & Numerical Data]
+ Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Body Weight
+ Case-Control Studies
+ *Diabetes Mellitus/ep [Epidemiology]
+ Diabetes Mellitus/vi [Virology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ Obesity/vi [Virology]
+ Prognosis
+ Risk Factors
+ United Arab Emirates/ep [Epidemiology]
+Abstract
+ Prior infection with adenovirus 36 (Adv36) has been associated with increased adiposity, improved insulin sensitivity, and a lower prevalence of diabetes. This study investigated the prevalence of Adv36 seropositivity and its association with obesity and diabetes among adults attending a diabetes centre in the UAE. Participants (N = 973) with different weight and glucose tolerance categories were recruited. Adv36 seropositivity (Adv36 + ) was assessed using ELISA. Differences among groups were analyzed using statistical tests as appropriate to the data. Prevalence of Adv36+ in the study population was 47%, with no significant difference in obese and non-obese subgroups (42.5% vs 49.6% respectively; p=non-significant). Females were more likely to be Adv36+ compared to males (odds ratio 1.78; 95% CI 1.36-2.32, p < 0.001). We found no significant association between Adv36 seropositivity and different BMI categories, or glucose tolerance status. In our population, the effect of Adv36 infection on lipid profile varied between healthy individuals and individuals with obesity. Adv36 infection is more prevalent in the UAE than in other countries but has no association with obesity. Our study found that females were more likely to be Adv36 positive regardless of weight or diabetes status.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-65008-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lessan&issn=2045-2322&title=Scientific+Reports&atitle=Obesity+and+Diabetes+in+an+Arab+population%3A+Role+of+Adenovirus+36+Infection.&volume=10&issue=1&spage=8107&epage=&date=2020&doi=10.1038%2Fs41598-020-65008-x&pmid=32415247&sid=OVID:medline
+
+<1332>
+Unique Identifier
+ 32407981
+Title
+ Adipose Tissue Hypertrophy, An Aberrant Biochemical Profile and Distinct Gene Expression in Lipedema.
+Source
+ Journal of Surgical Research. 253:294-303, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Felmerer G; Stylianaki A; Hagerling R; Wang A; Strobel P; Hollmen M; Lindenblatt N; Gousopoulos E
+Authors Full Name
+ Felmerer, Gunther; Stylianaki, Aikaterini; Hagerling, Rene; Wang, Anna; Strobel, Philipp; Hollmen, Maija; Lindenblatt, Nicole; Gousopoulos, Epameinondas.
+Institution
+ Felmerer, Gunther. Division of Plastic Surgery, Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Gottingen, Georg-August-University, Gottingen, Germany.
+ Stylianaki, Aikaterini. Division of Plastic Surgery, Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Gottingen, Georg-August-University, Gottingen, Germany.
+ Hagerling, Rene. Molecular and Clinical Sciences Institute, St. George's University of London, London, United Kingdom; Institute of Medical and Human Genetics, Charite Universitatsmedizin Berlin, Berlin, Germany.
+ Wang, Anna. Clinic of Plastic and Hand Surgery, University Hospital Zurich, Zurich, Switzerland.
+ Strobel, Philipp. Institute of Pathology, University Medical Center Gottingen, Georg-August-University, Gottingen, Germany.
+ Hollmen, Maija. MediCity Research Laboratory and Institute of Biomedicine, University of Turku, Turku, Finland.
+ Lindenblatt, Nicole. Clinic of Plastic and Hand Surgery, University Hospital Zurich, Zurich, Switzerland.
+ Gousopoulos, Epameinondas. Division of Plastic Surgery, Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Gottingen, Georg-August-University, Gottingen, Germany; Clinic of Plastic and Hand Surgery, University Hospital Zurich, Zurich, Switzerland. Electronic address: epameinondas.gousopoulos@usz.ch.
+MeSH Subject Headings
+ *Adipogenesis/ge [Genetics]
+ Adipokines/bl [Blood]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Biopsy
+ Case-Control Studies
+ Cytokines/an [Analysis]
+ Diagnosis, Differential
+ Female
+ Fibrosis
+ Gene Expression Profiling
+ Healthy Volunteers
+ Humans
+ Hypertrophy/bl [Blood]
+ Hypertrophy/di [Diagnosis]
+ Hypertrophy/ge [Genetics]
+ Hypertrophy/pa [Pathology]
+ Lipedema/bl [Blood]
+ *Lipedema/di [Diagnosis]
+ Lipedema/me [Metabolism]
+ Lipedema/pa [Pathology]
+ Lipid Metabolism/ge [Genetics]
+ Lipids/an [Analysis]
+ Lymphedema/bl [Blood]
+ Lymphedema/di [Diagnosis]
+ Lymphedema/me [Metabolism]
+ Lymphedema/pa [Pathology]
+ Macrophages/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Skin/pa [Pathology]
+ *Subcutaneous Fat/pa [Pathology]
+Keyword Heading
+ Adipocyte
+ Adipokine
+ Lipedema
+ Macrophage
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Lipedema is a common adipose tissue disorder affecting women, characterized by a symmetric subcutaneous adipose tissue deposition, particularly of the lower extremities. Lipedema is usually underdiagnosed, thus remaining an undertreated disease. Importantly, no histopathologic or molecular hallmarks exist to clearly diagnose the disease, which is often misinterpreted as obesity or lymphedema.
+
+ MATERIALS AND METHODS: The aim of the present study is to characterize in detail morphologic and molecular alterations in the adipose tissue composition of lipedema patients compared with healthy controls. Detailed histopathologic and molecular characterization was performed using lipid and cytokine quantification as well as gene expression arrays. The analysis was conducted on anatomically matched skin and fat tissue biopsies as well as fasting serum probes obtained from 10 lipedema and 11 gender and body mass index-matched control patients.
+
+ RESULTS: Histologic evaluation of the adipose tissue showed increased intercellular fibrosis and adipocyte hypertrophy. Serum analysis showed an aberrant lipid metabolism without changes in the circulating adipokines. In an adipogenesis gene array, a distinct gene expression profile associated with macrophages was observed. Histologic assessment of the immune cell infiltrate confirmed the increased presence of macrophages, without changes in the T-cell compartment.
+
+ CONCLUSIONS: Lipedema presents a distinguishable disease with typical tissue architecture and aberrant lipid metabolism, different to obesity or lymphedema. The differentially expressed genes and immune cell infiltration profile in lipedema patients further support these findings. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cytokines). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.jss.2020.03.055
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Felmerer&issn=0022-4804&title=Journal+of+Surgical+Research&atitle=Adipose+Tissue+Hypertrophy%2C+An+Aberrant+Biochemical+Profile+and+Distinct+Gene+Expression+in+Lipedema.&volume=253&issue=&spage=294&epage=303&date=2020&doi=10.1016%2Fj.jss.2020.03.055&pmid=32407981&sid=OVID:medline
+
+<1333>
+Unique Identifier
+ 32404980
+Title
+ Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention.
+Source
+ Scientific Reports. 10(1):7913, 2020 05 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Figarska SM; Rigdon J; Ganna A; Elmstahl S; Lind L; Gardner CD; Ingelsson E
+Authors Full Name
+ Figarska, Sylwia M; Rigdon, Joseph; Ganna, Andrea; Elmstahl, Solve; Lind, Lars; Gardner, Christopher D; Ingelsson, Erik.
+Institution
+ Figarska, Sylwia M. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
+ Figarska, Sylwia M. Stanford Cardiovascular Institute, Stanford, CA, 94305, USA.
+ Figarska, Sylwia M. Stanford Diabetes Research Center, Stanford, CA, 94305, USA.
+ Rigdon, Joseph. Quantitative Sciences Unit, Stanford University School of Medicine, Palo Alto, CA, 94304, USA.
+ Ganna, Andrea. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
+ Ganna, Andrea. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
+ Ganna, Andrea. Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
+ Elmstahl, Solve. Department of Clinical Sciences, Division of Geriatric Medicine, Lund University, Malmo University Hospital, Malmo, Sweden.
+ Lind, Lars. Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
+ Gardner, Christopher D. Stanford Diabetes Research Center, Stanford, CA, 94305, USA. cgardner@stanford.edu.
+ Gardner, Christopher D. Stanford Prevention Research Center, Department of Medicine, Stanford University Medical School, Stanford, CA, USA. cgardner@stanford.edu.
+ Ingelsson, Erik. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
+ Ingelsson, Erik. Stanford Cardiovascular Institute, Stanford, CA, 94305, USA.
+ Ingelsson, Erik. Stanford Diabetes Research Center, Stanford, CA, 94305, USA.
+ Ingelsson, Erik. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Body Mass Index
+ Cross-Sectional Studies
+ *Diet, Reducing
+ Early Medical Intervention
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Obesity/pc [Prevention & Control]
+ *Proteome
+ Proteomics/mt [Methods]
+ *Proteomics
+ *Weight Loss
+Abstract
+ Inflammatory and cardiovascular biomarkers have been associated with obesity, but little is known about how they change upon dietary intervention and concomitant weight loss. Further, protein biomarkers might be useful for predicting weight loss in overweight and obese individuals. We performed secondary analyses in the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) randomized intervention trial that included healthy 609 adults (18-50 years old) with BMI 28-40 kg/m2, to evaluate associations between circulating protein biomarkers and BMI at baseline, during a weight loss diet intervention, and to assess predictive potential of baseline blood proteins on weight loss. We analyzed 263 plasma proteins at baseline and 6 months into the intervention using the Olink Proteomics CVD II, CVD III and Inflammation arrays. BMI was assessed at baseline, after 3 and 6 months of dietary intervention. At baseline, 102 of the examined inflammatory and cardiovascular biomarkers were associated with BMI (>90% with successful replication in 1,584 overweight/obese individuals from a community-based cohort study) and 130 tracked with weight loss shedding light into the pathophysiology of obesity. However, out of 263 proteins analyzed at baseline, only fibroblast growth factor 21 (FGF-21) predicted weight loss, and none helped individualize dietary assignment.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteome).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs41598-020-64636-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Figarska&issn=2045-2322&title=Scientific+Reports&atitle=Proteomic+profiles+before+and+during+weight+loss%3A+Results+from+randomized+trial+of+dietary+intervention.&volume=10&issue=1&spage=7913&epage=&date=2020&doi=10.1038%2Fs41598-020-64636-7&pmid=32404980&sid=OVID:medline
+
+<1334>
+Unique Identifier
+ 32403230
+Title
+ Increasing the Duration of Light Physical Activity Ameliorates Insulin Resistance Syndrome in Metabolically Healthy Obese Adults.
+Source
+ Cells. 9(5), 2020 05 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Rashed F; Alghaith A; Azim R; AlMekhled D; Thomas R; Sindhu S; Ahmad R
+Author NameID
+ Al-Rashed, Fatema; ORCID: https://orcid.org/0000-0002-5825-7701
+ Sindhu, Sardar; ORCID: https://orcid.org/0000-0001-9936-1575
+ Ahmad, Rasheed; ORCID: https://orcid.org/0000-0001-5746-0743
+Authors Full Name
+ Al-Rashed, Fatema; Alghaith, Abdulwahab; Azim, Rafaat; AlMekhled, Dawood; Thomas, Reeby; Sindhu, Sardar; Ahmad, Rasheed.
+Institution
+ Al-Rashed, Fatema. Immunology & Microbiology Department, Dasman Diabetes Institute, Kuwait 15462, Kuwait.
+ Al-Rashed, Fatema. Kuwait Ministry of Health, Mubarak Al-Kabeer Hospital, Immunology Department, Kuwait 13001, Kuwait.
+ Alghaith, Abdulwahab. Royal College of Surgeons in Ireland (RCSI), D02 YN77 Dublin, Ireland.
+ Azim, Rafaat. Immunology & Microbiology Department, Dasman Diabetes Institute, Kuwait 15462, Kuwait.
+ AlMekhled, Dawood. Immunology & Microbiology Department, Dasman Diabetes Institute, Kuwait 15462, Kuwait.
+ Thomas, Reeby. Immunology & Microbiology Department, Dasman Diabetes Institute, Kuwait 15462, Kuwait.
+ Sindhu, Sardar. Animal and Imaging Core Facility, Dasman Diabetes Institute, Kuwait 15462, Kuwait.
+ Ahmad, Rasheed. Immunology & Microbiology Department, Dasman Diabetes Institute, Kuwait 15462, Kuwait.
+MeSH Subject Headings
+ Adult
+ Antigens, CD/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Cytokines/bl [Blood]
+ *Exercise
+ Female
+ Humans
+ *Insulin Resistance
+ Male
+ Monocytes/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Regression Analysis
+ Syndrome
+Keyword Heading
+ IRS
+ MHO
+ obesity
+ physical activity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a well-known risk factor for insulin resistance syndrome (IRS). Nevertheless, limited data are available regarding the effects of physical activity (PA) intensity on the ability to modulate IRS. The study aim was to investigate the beneficial effects of the longer duration of light PA vs. a single bout of the acute moderate or vigorous PA for improvement in IRS indicators. Sixty metabolically healthy obese (MHO) participants, 30 males and 30 females, with body mass index (BMI) of >=30 were enrolled in this study. PA levels were measured using an accelerometer, and the expression of monocytic surface markers was analyzed using flow cytometry. Plasma cytokines' secretion was determined by enzyme-linked immunosorbent assay (ELISA). Univariate regression analysis evaluated the actigraphy-assessed PA measures, inflammatory cytokines, and insulin resistance. The longer duration of PA was found to be associated with the homeostatic model assessment of insulin resistance (HOMA-IR), a lower lipid profile, and the expression of inflammatory cytokines by monocytes. Even though, higher intensities of PA were found to be associated with lower body fat percentage, only the light intensity PA was found to be beneficial as it associated with the improved insulin sensitivity and lower expression of inflammatory markers. In conclusion, maintaining the longer duration of low-intensity PA throughout the day could be more beneficial for reducing inflammation and improving insulin resistance. This study supports a more feasible approach model to gain beneficial lifestyle changes for the prevention of IRS in metabolically healthy adults with obesity.
+Registry Number/Name of Substance
+ 0 (Antigens, CD). 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fcells9051189
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Rashed&issn=2073-4409&title=Cells&atitle=Increasing+the+Duration+of+Light+Physical+Activity+Ameliorates+Insulin+Resistance+Syndrome+in+Metabolically+Healthy+Obese+Adults.&volume=9&issue=5&spage=&epage=&date=2020&doi=10.3390%2Fcells9051189&pmid=32403230&sid=OVID:medline
+
+<1335>
+Unique Identifier
+ 32398007
+Title
+ Elevated glycosylated hemoglobin levels and their interactive effects on hypertension risk in nondiabetic Chinese population: a cross-sectional survey.
+Source
+ BMC Cardiovascular Disorders. 20(1):218, 2020 05 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Song J; Wei N; Zhao Y; Jiang Y; Wu X; Gao H
+Author NameID
+ Gao, Huaiquan; ORCID: https://orcid.org/0000-0002-2461-0706
+Authors Full Name
+ Song, Jian; Wei, Nana; Zhao, Yingying; Jiang, Yuhong; Wu, Xuesen; Gao, Huaiquan.
+Institution
+ Song, Jian. School of public health, Bengbu medical college, Bengbu, 233000, Anhui Province, China.
+ Wei, Nana. Department of general medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, Anhui Province, China.
+ Zhao, Yingying. Bengbu health board, 568 Nanhu road, Bengbu, 233000, Anhui Province, China.
+ Jiang, Yuhong. School of public health, Bengbu medical college, Bengbu, 233000, Anhui Province, China.
+ Wu, Xuesen. School of public health, Bengbu medical college, Bengbu, 233000, Anhui Province, China.
+ Gao, Huaiquan. School of public health, Bengbu medical college, Bengbu, 233000, Anhui Province, China. ghqbbmc@sina.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Blood Pressure
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ *Glucose Metabolism Disorders/bl [Blood]
+ Glucose Metabolism Disorders/di [Diagnosis]
+ Glucose Metabolism Disorders/ep [Epidemiology]
+ *Glycated Hemoglobin/me [Metabolism]
+ Health Surveys
+ Humans
+ Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ *Hypertension/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Up-Regulation
+Keyword Heading
+ HbA1c
+ Hypertension
+ Interaction
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Abnormal glucose metabolism has been suggested to be involved in the development of hypertension. This study investigated the effect of the association and potential interaction of glycosylated hemoglobin (HbA1c) and other factors on the risk of hypertension among Chinese nondiabetic adults.
+
+ METHODS: As a cross-sectional survey, the current work deployed a questionnaire survey, anthropometric tests, and biochemical measures for each of the eligible participants. The HbA1c levels were quantified and grouped by quartiles. Correlations between HbA1c and hypertension, isolated systolic hypertension (ISH), and isolated diastolic hypertension (IDH) risk were investigated by logistic analyses. For evaluating the interactive effects, the parameters of relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI) were calculated, respectively.
+
+ RESULTS: In the current study, 1462 nondiabetic subjects were enrolled. In total, the prevalence rates of hypertension, ISH and IDH were 22.4, 9.6 and 4.5%, respectively. When HbA1c levels were grouped by quartile, it was revealed that the prevalence rates of hypertension and ISH were substantially elevated across groups (Pfor trend < 0.001). In the multivariable logistic regression analyses, in comparison with the first quartile of HbA1c, the normalized OR for hypertension risk was 1.90 (95% CI: 1.28-2.80) for the highest quartile. Also, the risk of ISH was significantly increased with HbA1c level in the highest quartile relative to in the bottom quartile (OR: 2.23,95% CI:1.47-3.71). However, no significant relationship between the HbA1c level and IDH risk was observed (OR: 1.78, 95% CI: 0.82-3.84). Eventually, it was demonstrated from the interactive effect analysis that HbA1c significantly interacted with abdominal obesity (RERI: 1.48, 95% CI: 0.38-2.58; AP: 0.37, 95% CI: 0.14-0.60 and SI: 1.96, 95% CI: 1.06-3.62) and family history of hypertension (AP: 0.37, 95% CI: 0.05-0.70) in influencing the risk of hypertension in nondiabetic participants.
+
+ CONCLUSION: Higher HbA1c levels significantly enhanced the risk of hypertension and ISH, but not IDH among Chinese nondiabetic adults. Moreover, the risk of hypertension was also aggravated by the upregulated HbA1c in a synergistic manner alongside abdominal obesity and family history of hypertension.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1186%2fs12872-020-01501-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Song&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Elevated+glycosylated+hemoglobin+levels+and+their+interactive+effects+on+hypertension+risk+in+nondiabetic+Chinese+population%3A+a+cross-sectional+survey.&volume=20&issue=1&spage=218&epage=&date=2020&doi=10.1186%2Fs12872-020-01501-5&pmid=32398007&sid=OVID:medline
+
+<1336>
+Unique Identifier
+ 32396288
+Title
+ Comparison of the effects of different weekly frequencies of resistance training on metabolic health markers and body fat in older women.
+Source
+ Journal of Sports Medicine & Physical Fitness. 60(4):618-624, 2020 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pina FL; Nunes JP; Ribeiro AS; Nascimento MA; Cyrino LT; Carneiro NH; Venturini D; Barbosa DS; Mayhew JL; Cyrino ES
+Authors Full Name
+ Pina, Fabio L; Nunes, Joao P; Ribeiro, Alex S; Nascimento, Matheus A; Cyrino, Leticia T; Carneiro, Nelson H; Venturini, Danielle; Barbosa, Decio S; Mayhew, Jerry L; Cyrino, Edilson S.
+Institution
+ Pina, Fabio L. Center for Research in Health Sciences, University of Northern Parana, Londrina, Brazil.
+ Pina, Fabio L. Laboratory of Metabolism, Nutrition, and Exercise, Physical Education and Sport Center, Londrina State University, Londrina, Brazil.
+ Nunes, Joao P. Laboratory of Metabolism, Nutrition, and Exercise, Physical Education and Sport Center, Londrina State University, Londrina, Brazil - joaonunes.jpn@hotmail.com.
+ Ribeiro, Alex S. Center for Research in Health Sciences, University of Northern Parana, Londrina, Brazil.
+ Ribeiro, Alex S. Laboratory of Metabolism, Nutrition, and Exercise, Physical Education and Sport Center, Londrina State University, Londrina, Brazil.
+ Nascimento, Matheus A. Laboratory of Metabolism, Nutrition, and Exercise, Physical Education and Sport Center, Londrina State University, Londrina, Brazil.
+ Nascimento, Matheus A. Parana State University, Paranavai Campus, Paranavai, Brazil.
+ Cyrino, Leticia T. Laboratory of Metabolism, Nutrition, and Exercise, Physical Education and Sport Center, Londrina State University, Londrina, Brazil.
+ Carneiro, Nelson H. Laboratory of Metabolism, Nutrition, and Exercise, Physical Education and Sport Center, Londrina State University, Londrina, Brazil.
+ Venturini, Danielle. Clinical Analyses Laboratory, Londrina State University, Londrina, Brazil.
+ Barbosa, Decio S. Clinical Analyses Laboratory, Londrina State University, Londrina, Brazil.
+ Mayhew, Jerry L. Truman State University, Kirksville, MO, USA.
+ Cyrino, Edilson S. Laboratory of Metabolism, Nutrition, and Exercise, Physical Education and Sport Center, Londrina State University, Londrina, Brazil.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Aged
+ Biomarkers/bl [Blood]
+ Body Composition
+ Exercise Therapy
+ *Fats/me [Metabolism]
+ Female
+ Humans
+ Longitudinal Studies
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/th [Therapy]
+ *Resistance Training
+ Triglycerides/bl [Blood]
+Abstract
+ BACKGROUND: The purpose of this study was to compare the effects of a 24-week resistance-training (RT) program performed 2 vs. 3 times per week on body fat and metabolic health markers in older women.
+
+ METHODS: Thirty-nine women (>=60 years old) were randomly assigned to two groups according to RT frequency (G2x=two sessions per week, N.=19; and G3x=three sessions per week, N.=20) and were submitted to two 12-week stages of whole-body RT. In the first stage, participants performed 1 set of 10 to 15 repetitions in each of eight exercises, whereas in the second stage, they performed 2 sets of 10 to 15 repetitions. Body fat was estimated by DXA, while biochemical analyses were performed on venous blood samples collected in the morning hours after a 12 hours' fasting and after a minimum of 48 hours since the last physical exercise session.
+
+ RESULTS: After the 24 weeks of RT, only G3x significantly reduced body fat mass (G2x=0.0%; G3x=-5.1%), whereas both G2x and G3x reduced blood glucose and C-reactive protein levels. Both groups improved HDL-C after the first 12-week stage compared to baseline, although the changes from pre- to post-training were not significantly different between groups. No significant difference was observed compared to baseline for total cholesterol, VLDL-C, LDL-C, and triglycerides for either group.
+
+ CONCLUSIONS: These results suggest that RT-induced changes in health markers may occur regardless of RT frequency, whereas performing RT three times per week may be needed for reducing total body fat mass in older women.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fats). 0 (Triglycerides).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.23736%2fS0022-4707.20.10315-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pina&issn=0022-4707&title=Journal+of+Sports+Medicine+%26+Physical+Fitness&atitle=Comparison+of+the+effects+of+different+weekly+frequencies+of+resistance+training+on+metabolic+health+markers+and+body+fat+in+older+women.&volume=60&issue=4&spage=618&epage=624&date=2020&doi=10.23736%2FS0022-4707.20.10315-3&pmid=32396288&sid=OVID:medline
+
+<1337>
+Unique Identifier
+ 32394219
+Title
+ The Effects of Acceptance and Commitment Therapy (ACT) Intervention on Inflammation and Stress Biomarkers: a Randomized Controlled Trial.
+Source
+ International Journal of Behavioral Medicine. 27(5):539-555, 2020 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jarvela-Reijonen E; Puttonen S; Karhunen L; Sairanen E; Laitinen J; Kolehmainen M; Pihlajamaki J; Kujala UM; Korpela R; Ermes M; Lappalainen R; Kolehmainen M
+Author NameID
+ Jarvela-Reijonen, Elina; ORCID: https://orcid.org/0000-0002-9346-3340
+Authors Full Name
+ Jarvela-Reijonen, Elina; Puttonen, Sampsa; Karhunen, Leila; Sairanen, Essi; Laitinen, Jaana; Kolehmainen, Mikko; Pihlajamaki, Jussi; Kujala, Urho M; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kolehmainen, Marjukka.
+Institution
+ Jarvela-Reijonen, Elina. Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland. elina.jarvela-reijonen@uef.fi.
+ Puttonen, Sampsa. Finnish Institute of Occupational Health, P.O. Box 40, FI-00251, Helsinki, Finland.
+ Karhunen, Leila. Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
+ Karhunen, Leila. Institute of Clinical Medicine and Clinical Nutrition, Kuopio University Hospital, P.O. Box 100, FI-70029 KYS, Kuopio, Finland.
+ Sairanen, Essi. Department of Psychology, University of Jyvaskyla, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
+ Sairanen, Essi. Department of Social and Psychological Studies, Karlstad University, SE-651 88, Karlstad, Sweden.
+ Laitinen, Jaana. Finnish Institute of Occupational Health, P.O. Box 40, FI-00251, Helsinki, Finland.
+ Kolehmainen, Mikko. Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
+ Pihlajamaki, Jussi. Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
+ Pihlajamaki, Jussi. Institute of Clinical Medicine and Clinical Nutrition, Kuopio University Hospital, P.O. Box 100, FI-70029 KYS, Kuopio, Finland.
+ Kujala, Urho M. Faculty of Sport and Health Sciences, University of Jyvaskyla, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
+ Korpela, Riitta. Medical Faculty, Pharmacology, Medical Nutrition Physiology and Human Microbe Research Program, University of Helsinki, P.O. Box 63, FI-00014, Helsinki, Finland.
+ Ermes, Miikka. Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
+ Ermes, Miikka. VTT Technical Research Centre of Finland, P.O. Box 1300, FI-33101, Tampere, Finland.
+ Lappalainen, Raimo. Department of Psychology, University of Jyvaskyla, P.O. Box 35, FI-40014, Jyvaskyla, Finland.
+ Kolehmainen, Marjukka. Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
+ Kolehmainen, Marjukka. Institute of Clinical Medicine and Clinical Nutrition, Kuopio University Hospital, P.O. Box 100, FI-70029 KYS, Kuopio, Finland.
+MeSH Subject Headings
+ *Acceptance and Commitment Therapy
+ Adult
+ Biomarkers
+ Humans
+ Inflammation
+ Obesity/th [Therapy]
+ Overweight
+Keyword Heading
+ ACT
+ Low-grade inflammation
+ Mindfulness
+ Obesity
+ Psychological flexibility
+ Stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Psychological processes can be manifested in physiological health. We investigated whether acceptance and commitment therapy (ACT), targeted on psychological flexibility (PF), influences inflammation and stress biomarkers among working-age adults with psychological distress and overweight/obesity.
+
+ METHOD: Participants were randomized into three parallel groups: (1) ACT-based face-to-face (n = 65; six group sessions led by a psychologist), (2) ACT-based mobile (n = 73; one group session and mobile app), and (3) control (n = 66; only the measurements). Systemic inflammation and stress markers were analyzed at baseline, at 10 weeks after the baseline (post-intervention), and at 36 weeks after the baseline (follow-up). General PF and weight-related PF were measured with questionnaires (Acceptance and Action Questionnaire, Acceptance and Action Questionnaire for Weight-Related Difficulties).
+
+ RESULTS: A group x time interaction (p = .012) was detected in the high-sensitivity C-reactive protein (hsCRP) level but not in other inflammation and stress biomarkers. hsCRP decreased significantly in the face-to-face group from week 0 to week 36, and at week 36, hsCRP was lower among the participants in the face-to-face group than in the mobile group (p = .035, post hoc test). Age and sex were stronger predictors of biomarker levels at follow-up than the post-intervention PF.
+
+ CONCLUSION: The results suggest that ACT delivered in group sessions may exert beneficial effects on low-grade systemic inflammation. More research is needed on how to best apply psychological interventions for the health of both mind and body among people with overweight/obesity and psychological distress.
+
+ TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01738256, Registered 17 August, 2012.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs12529-020-09891-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jarvela-Reijonen&issn=1070-5503&title=International+Journal+of+Behavioral+Medicine&atitle=The+Effects+of+Acceptance+and+Commitment+Therapy+%28ACT%29+Intervention+on+Inflammation+and+Stress+Biomarkers%3A+a+Randomized+Controlled+Trial.&volume=27&issue=5&spage=539&epage=555&date=2020&doi=10.1007%2Fs12529-020-09891-8&pmid=32394219&sid=OVID:medline
+
+<1338>
+Unique Identifier
+ 32388329
+Title
+ Prevalence of metabolic syndrome in patients with chronic obstructive pulmonary disease: An observational study in South Indians.
+Source
+ Diabetes & Metabolic Syndrome. 14(4):503-507, 2020 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Priyadharshini N; Renusha RC; Reshma S; Sindhuri Sai M; Koushik Muthu RM; Rajanandh MG
+Authors Full Name
+ Priyadharshini, N; Renusha, R C; Reshma, S; Sindhuri Sai, Marella; Koushik Muthu, Raja M; Rajanandh, M G.
+Institution
+ Priyadharshini, N. Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Deemed to be University (DU), Porur, Chennai, 600 116, Tamil Nadu, India.
+ Renusha, R C. Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Deemed to be University (DU), Porur, Chennai, 600 116, Tamil Nadu, India.
+ Reshma, S. Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Deemed to be University (DU), Porur, Chennai, 600 116, Tamil Nadu, India.
+ Sindhuri Sai, Marella. Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Deemed to be University (DU), Porur, Chennai, 600 116, Tamil Nadu, India.
+ Koushik Muthu, Raja M. Department of Respiratory Medicine, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Deemed to be University (DU), Porur, Chennai, 600 116, Tamil Nadu, India.
+ Rajanandh, M G. Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Deemed to be University (DU), Porur, Chennai, 600 116, Tamil Nadu, India. Electronic address: rajanandh.mg@sriramachandra.edu.in.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Follow-Up Studies
+ Humans
+ India/ep [Epidemiology]
+ Male
+ *Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/pa [Pathology]
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prevalence
+ Prognosis
+ *Pulmonary Disease, Chronic Obstructive/co [Complications]
+ *Quality of Life
+ Risk Factors
+Keyword Heading
+ Blood pressure
+ Central obesity
+ Fasting blood glucose
+ Lipid abnormalities
+ Waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Metabolic syndrome (MetS) has a significant association with airflow obstruction and physical inactivity, which are the relevant extra-pulmonary markers of chronic obstructive respiratory disease (COPD). This study aimed to estimate the prevalence of MetS and its correlation with comorbidities and health related quality of life (HRQoL) in South Indian patients with COPD.
+
+ METHODS: A cross-sectional study was conducted among the 76 COPD patients. Pulmonary function test (PFT) and parameters for MetS such as waist circumference, blood pressure, fasting blood glucose, triglycerides (TGs) and high density lipoprotein cholesterol (HDL-C) levels of COPD patients were measured. HRQoL was calculated using Saint George Respiratory Questionnaire (SGRQ).
+
+ RESULTS: 54% of COPD patients were presented with MetS especially in stage II and III. TGs and HDL-C were significantly associated with the severity of COPD (p < 0.05), while waist circumference, TGs and HDL-C were significantly (p < 0.05) correlated with PFT. Symptom, activity, impact and total scores of SGRQ was increased statistically (p < 0.05) in COPD patients with MetS than without MetS.
+
+ CONCLUSION: According to our findings, screening the grade II and III COPD patients for the presence of MetS is a reasonable option. The results of this study should be confirmed with a larger sample of population. Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.dsx.2020.04.042
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Priyadharshini&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Prevalence+of+metabolic+syndrome+in+patients+with+chronic+obstructive+pulmonary+disease%3A+An+observational+study+in+South+Indians.&volume=14&issue=4&spage=503&epage=507&date=2020&doi=10.1016%2Fj.dsx.2020.04.042&pmid=32388329&sid=OVID:medline
+
+<1339>
+Unique Identifier
+ 32387306
+Title
+ Biocompatible modified water as a non-pharmaceutical approach to prevent metabolic syndrome features in obesogenic diet-fed mice.
+Source
+ Food & Chemical Toxicology. 141:111403, 2020 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lambert K; Gondeau C; Briolotti P; Scheuermann V; Daujat-Chavanieu M; Aimond F
+Authors Full Name
+ Lambert, Karen; Gondeau, Claire; Briolotti, Philippe; Scheuermann, Valerie; Daujat-Chavanieu, Martine; Aimond, Franck.
+Institution
+ Lambert, Karen. PhyMedExp, Universite Montpellier, INSERM, CNRS, France.
+ Gondeau, Claire. IRMB, Universite Montpellier, INSERM, CHU Montpellier, Montpellier, France.
+ Briolotti, Philippe. IRMB, Universite Montpellier, INSERM, Montpellier, France.
+ Scheuermann, Valerie. PhyMedExp, Universite Montpellier, INSERM, CNRS, France.
+ Daujat-Chavanieu, Martine. IRMB, Universite Montpellier, INSERM, CHU Montpellier, Montpellier, France.
+ Aimond, Franck. PhyMedExp, Universite Montpellier, INSERM, CNRS, France. Electronic address: franck.aimond@inserm.fr.
+MeSH Subject Headings
+ Animals
+ Basal Metabolism
+ *Biocompatible Materials
+ Biomarkers/me [Metabolism]
+ *Diet, High-Fat
+ *Drinking Water
+ Insulin Resistance
+ Lipogenesis
+ Liver Glycogen/me [Metabolism]
+ Male
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome/pc [Prevention & Control]
+ Mice
+ Mice, Inbred C57BL
+ Obesity/co [Complications]
+ *Obesity/et [Etiology]
+Keyword Heading
+ Biocompatible modified water
+ Hepatic steatosis
+ High fat high sucrose diet
+ Insulin resistance
+ Metabolic syndrome
+ Tap water
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The prevalence of metabolic syndrome (MetS), elevating cardiovascular risks, is increasing worldwide, with no available global therapeutic options. The intake of plain, mineral or biocompatible modified waters was shown to prevent some MetS features. This study was designed to analyze, in mice fed a high fat and sucrose diet (HFSD), the effects on MetS features of the daily intake of a reverse osmosed, weakly remineralized, water (OW) and of an OW dynamized by a physical processing (ODW), compared to tap water (TW). The HFSD was effective at inducing major features of MetS such as obesity, hepatic steatosis and inflammation, blood dyslipidemia, systemic glucose intolerance and muscle insulin resistance. Compared to TW, OW intake decreased hepatic fibrosis and inflammation, and mitigated hepatic steatosis and dyslipidemia. ODW intake further improved skeletal muscle insulin sensitivity and systemic glucose tolerance. This study highlights the deleterious metabolic impacts of the daily intake of TW, in combination with a high energy diet, and its possible involvement in MetS prevalence increase. In addition, it demonstrates that biocompatible modified water may be promising non-pharmaceutical, cost-effective tools for nutritional approaches in the treatment of MetS. Copyright © 2020 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biocompatible Materials). 0 (Biomarkers). 0 (Drinking Water). 0 (Liver Glycogen).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.fct.2020.111403
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lambert&issn=0278-6915&title=Food+%26+Chemical+Toxicology&atitle=Biocompatible+modified+water+as+a+non-pharmaceutical+approach+to+prevent+metabolic+syndrome+features+in+obesogenic+diet-fed+mice.&volume=141&issue=&spage=111403&epage=&date=2020&doi=10.1016%2Fj.fct.2020.111403&pmid=32387306&sid=OVID:medline
+
+<1340>
+Unique Identifier
+ 32385781
+Title
+ Microalbuminuria and Serum Cystatin C in Prediction of Early-Renal Insufficiency in Children with Obesity.
+Source
+ Indian Journal of Pediatrics. 87(12):1009-1013, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Oz-Sig O; Kara O; Erdogan H
+Author NameID
+ Oz-Sig, Ozlem; ORCID: https://orcid.org/0000-0001-9363-1263
+ Kara, Ozlem; ORCID: https://orcid.org/0000-0003-0915-5546
+ Erdogan, Hakan; ORCID: https://orcid.org/0000-0002-5212-9282
+Authors Full Name
+ Oz-Sig, Ozlem; Kara, Ozlem; Erdogan, Hakan.
+Institution
+ Oz-Sig, Ozlem. Department of Pediatrics, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
+ Kara, Ozlem. Department of Pediatric Endocrinology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. dr.ozlemkara@hotmail.com.
+ Erdogan, Hakan. Department of Pediatric Nephrology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adolescent
+ Albuminuria
+ Biomarkers
+ Child
+ Child, Preschool
+ Creatinine
+ Cystatin C
+ Diabetes Mellitus, Type 2/co [Complications]
+ Glomerular Filtration Rate
+ Humans
+ Obesity/co [Complications]
+ *Obesity
+ Renal Insufficiency/di [Diagnosis]
+ Renal Insufficiency/et [Etiology]
+ *Renal Insufficiency
+Keyword Heading
+ Diabetes mellitus
+ Early-renal insufficiency
+ Microalbuminuria
+ Obesity
+ Serum cystatin-C
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Serum cystatin-C (SCysC) and microalbuminuria are well-recognized early markers of renal damage. This study aims to assess whether these early markers are elevated in children with obesity and normal serum creatinine (SCr).
+
+ METHODS: Pediatric patients diagnosed with obesity were included (n = 105, ages 4-18 y) in this study. The patients were divided into three groups as follows: solely obese, metabolic syndrome and type 2 diabetes. Serum cystatin-C, 24-h microalbuminuria, SCr and glomerular filtration rate (GFR) were evaluated in all patients. All patients were examined with history, physical examination, laboratory analysis and ultrasonography evaluation.
+
+ RESULTS: The findings showed that renal function, GFR and SCr levels were normal in all patients. There was microalbuminuria in six patients and SCysC was elevated in eight patients. There were also both elevated SCysC and microalbuminuria in eight patients. Significant elevations of both microalbuminuria and SCysC were detected in cases with type 2 diabetes (p < 0.05).
+
+ CONCLUSIONS: The findings suggest that SCysC may have a diagnostic value in early-renal insufficiency. Although there was not any statistically significant difference between groups in GFR, significant elevations for both microalbuminuria and SCysC in patients with type 2 diabetes were detected. This suggests that the risk factors of diabetes may have a direct relation with renal damage. Regarding renal function in type 2 diabetic and obese pediatric patients, microalbuminuria and SCysC may be screened to observe early-renal damage, even in cases with normal GFR and SCr levels.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cystatin C). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1007%2fs12098-020-03294-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Oz-Sig&issn=0019-5456&title=Indian+Journal+of+Pediatrics&atitle=Microalbuminuria+and+Serum+Cystatin+C+in+Prediction+of+Early-Renal+Insufficiency+in+Children+with+Obesity.&volume=87&issue=12&spage=1009&epage=1013&date=2020&doi=10.1007%2Fs12098-020-03294-z&pmid=32385781&sid=OVID:medline
+
+<1341>
+Unique Identifier
+ 32382066
+Title
+ Neural regulation of energy and bone homeostasis by the synaptic adhesion molecule Calsyntenin-3.
+Source
+ Experimental & Molecular Medicine. 52(5):793-803, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim SJ; Jeong YT; Jeong SR; Park M; Go HS; Kim MY; Seong JK; Kim KW; Seo JT; Kim CH; Lee JH; Moon SJ
+Author NameID
+ Park, Munsu; ORCID: http://orcid.org/0000-0001-9653-9235
+ Kim, Ki Woo; ORCID: http://orcid.org/0000-0002-7790-1515
+ Moon, Seok Jun; ORCID: http://orcid.org/0000-0001-7282-2888
+Authors Full Name
+ Kim, Sung-Jin; Jeong, Yong Taek; Jeong, Se Rok; Park, Munsu; Go, Hye Sun; Kim, Mi Young; Seong, Je Kyung; Kim, Ki Woo; Seo, Jeong Taeg; Kim, Chul Hoon; Lee, Ji Hyun; Moon, Seok Jun.
+Institution
+ Kim, Sung-Jin. Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
+ Jeong, Yong Taek. Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
+ Jeong, Yong Taek. Department of Pharmacology, Korea University College of Medicine, Seoul, 02841, Korea.
+ Jeong, Se Rok. Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
+ Park, Munsu. Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul, Korea.
+ Go, Hye Sun. Korea Mouse Phenotyping Center (KMPC), Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
+ Kim, Mi Young. Korea Mouse Phenotyping Center (KMPC), Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
+ Seong, Je Kyung. Korea Mouse Phenotyping Center (KMPC), Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
+ Kim, Ki Woo. Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
+ Seo, Jeong Taeg. Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
+ Kim, Chul Hoon. Department of Pharmacology, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
+ Lee, Ji Hyun. Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul, Korea.
+ Moon, Seok Jun. Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea. sjmoon@yuhs.ac.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Bone Density
+ Bone and Bones/dg [Diagnostic Imaging]
+ *Bone and Bones/me [Metabolism]
+ Bone and Bones/pa [Pathology]
+ *Calcium-Binding Proteins/ge [Genetics]
+ Calcium-Binding Proteins/me [Metabolism]
+ Cells, Cultured
+ Diet
+ *Energy Metabolism
+ Gene Expression
+ Glucose/me [Metabolism]
+ *Homeostasis
+ Hypothalamus/me [Metabolism]
+ Leptin/me [Metabolism]
+ *Membrane Proteins/ge [Genetics]
+ Membrane Proteins/me [Metabolism]
+ Mice
+ Mice, Knockout
+ *Neurons/me [Metabolism]
+ Obesity
+ Organ Size
+ *Synapses/me [Metabolism]
+Abstract
+ Neuronal regulation of energy and bone metabolism is important for body homeostasis. Many studies have emphasized the importance of synaptic adhesion molecules in the formation of synapses, but their roles in physiology still await further characterization. Here, we found that the synaptic adhesion molecule Calsyntenin-3 (CLSTN3) regulates energy and bone homeostasis. Clstn3 global knockout mice show reduced body mass with improved leptin sensitivity and increased energy expenditure compared to their wild-type littermates. In addition, Clstn3 knockout mice show reduced marrow volume and cortical bone mass without alteration of trabecular bone microarchitecture. This reduced bone mass is not bone cell-autonomous because neither osteoblast- nor osteoclast-specific Clstn3 knockout mice show bone defects; similarly, in vitro cultures of both Clstn3 knockout osteoblasts and osteoclasts do not show any defects. These reduced body and bone mass phenotypes can be attributed instead to neuronal CLSTN3 because they are recapitulated by pan-neuronal but not sympathetic neuron-specific deletion of Clstn3. This study reveals novel physiological functions of neuronal Clstn3 as a key regulator of energy and bone homeostasis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Calcium-Binding Proteins). 0 (Clstn3 protein, mouse). 0 (Leptin). 0 (Membrane Proteins). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1038%2fs12276-020-0419-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1226-3613&title=Experimental+%26+Molecular+Medicine&atitle=Neural+regulation+of+energy+and+bone+homeostasis+by+the+synaptic+adhesion+molecule+Calsyntenin-3.&volume=52&issue=5&spage=793&epage=803&date=2020&doi=10.1038%2Fs12276-020-0419-8&pmid=32382066&sid=OVID:medline
+
+<1342>
+Unique Identifier
+ 32380746
+Title
+ Consumption of Goat Cheese Naturally Rich in Omega-3 and Conjugated Linoleic Acid Improves the Cardiovascular and Inflammatory Biomarkers of Overweight and Obese Subjects: A Randomized Controlled Trial.
+Source
+ Nutrients. 12(5), 2020 May 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Santurino C; Lopez-Plaza B; Fontecha J; Calvo MV; Bermejo LM; Gomez-Andres D; Gomez-Candela C
+Author NameID
+ Lopez-Plaza, Bricia; ORCID: https://orcid.org/0000-0001-9310-1545
+ Fontecha, Javier; ORCID: https://orcid.org/0000-0001-5719-2304
+ Calvo, Maria V; ORCID: https://orcid.org/0000-0002-6785-7661
+ Bermejo, Laura M; ORCID: https://orcid.org/0000-0001-6826-0181
+Authors Full Name
+ Santurino, Cristina; Lopez-Plaza, Bricia; Fontecha, Javier; Calvo, Maria V; Bermejo, Laura M; Gomez-Andres, David; Gomez-Candela, Carmen.
+Institution
+ Santurino, Cristina. Nutrition Research Group, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain.
+ Lopez-Plaza, Bricia. Nutrition Research Group, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain.
+ Fontecha, Javier. Food Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL, CSIC), Campus of Autonomous University of Madrid, 28049 Madrid, Spain.
+ Calvo, Maria V. Food Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL, CSIC), Campus of Autonomous University of Madrid, 28049 Madrid, Spain.
+ Bermejo, Laura M. Nutrition Research Group, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain.
+ Gomez-Andres, David. Department of Anatomy, Histology and Neuroscience, School of Medicine, Autonomous University of Madrid, 28049 Madrid, Spain.
+ Gomez-Andres, David. Pediatric Neurology Unit, Hospital Universitari Vall d'Hebron, VHIR, 08035 Barcelona, Spain.
+ Gomez-Candela, Carmen. Nutrition Research Group, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain.
+ Gomez-Candela, Carmen. Dietetic and Clinical Nutrition Department, La Paz, University Hospital, 28046 Madrid, Spain.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Animals
+ Apolipoproteins B/bl [Blood]
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ *Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pc [Prevention & Control]
+ Cheese/an [Analysis]
+ *Cheese
+ *Cholesterol, HDL/bl [Blood]
+ *Dietary Supplements
+ Double-Blind Method
+ *Fatty Acids, Omega-3/ad [Administration & Dosage]
+ *Fatty Acids, Omega-3/an [Analysis]
+ Female
+ *Goats
+ Heart Disease Risk Factors
+ Humans
+ Inflammation/di [Diagnosis]
+ Inflammation/et [Etiology]
+ Inflammation/pc [Prevention & Control]
+ *Linoleic Acid/ad [Administration & Dosage]
+ *Linoleic Acid/an [Analysis]
+ Male
+ Middle Aged
+ *Nutritional Physiological Phenomena/ph [Physiology]
+ *Obesity/co [Complications]
+ *Obesity/dt [Drug Therapy]
+ *Overweight/co [Complications]
+ *Overweight/dt [Drug Therapy]
+ Peptide Fragments/bl [Blood]
+ Risk Factors
+ Young Adult
+Keyword Heading
+ CLA
+ blood lipids
+ cheese
+ dairy fat
+ n-3 PUFA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study examines the value of a goat cheese naturally enriched in polyunsaturated fatty acids (PUFA) (n-3 PUFA and conjugated linolenic acid (CLA)) as means of improving cardiovascular and inflammatory health. Sixty-eight overweight and obese subjects (BMI >= 27 and <40 kg/m2), with at least two risk factors for cardiovascular disease (CVD) in a lipid panel blood tests, participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed for 12 weeks: (1) 60 g/d control goat cheese and (2) 60 g/d goat cheese naturally enriched in n-3 PUFA and CLA. Diet and physical activity were assessed. Anthropometric and dual-energy X-ray absorptiometry (DXA) tests were performed. Blood samples were collected at the beginning and at the end of the study period. Changes in health status, lifestyle and dietary habits, and daily compliance were recorded. The consumption of a PUFA-enriched goat cheese significantly increased plasma high-density lipoprotein (HDL)-cholesterol, as well as in apolipoprotein B, and it significantly decreased high-sensitivity C-reactive protein concentrations compared to the control goat cheese (p < 0.05). The significant improvement of the plasma lipid profile and inflammatory status of people with risk for CVD due to the consumption of PUFA-enriched cheese suggests a potential role of this dairy product as an alternative to develop high nutritional value food in a balanced diet comprising regular exercise.
+Registry Number/Name of Substance
+ 0 (Apolipoproteins B). 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Fatty Acids, Omega-3). 0 (Peptide Fragments). 0 (apolipoprotein B (3304-3317)). 9007-41-4 (C-Reactive Protein). 9KJL21T0QJ (Linoleic Acid).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.3390%2fnu12051315
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Santurino&issn=2072-6643&title=Nutrients&atitle=Consumption+of+Goat+Cheese+Naturally+Rich+in+Omega-3+and+Conjugated+Linoleic+Acid+Improves+the+Cardiovascular+and+Inflammatory+Biomarkers+of+Overweight+and+Obese+Subjects%3A+A+Randomized+Controlled+Trial.&volume=12&issue=5&spage=&epage=&date=2020&doi=10.3390%2Fnu12051315&pmid=32380746&sid=OVID:medline
+
+<1343>
+Unique Identifier
+ 32372543
+Title
+ Joint impact of muscle mass and waist circumference on type 2 diabetes in Japanese middle-aged adults: The Circulatory Risk in Communities Study (CIRCS).
+Source
+ Journal Of Diabetes. 12(9):677-685, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yasuoka M; Muraki I; Imano H; Jinnouchi H; Kubota Y; Hayama-Terada M; Umesawa M; Yamagishi K; Ohira T; Kitamura A; Okada T; Kiyama M; Iso H
+Author NameID
+ Iso, Hiroyasu; ORCID: https://orcid.org/0000-0002-9241-7289
+Corporate Author
+ CIRCS Investigators
+Authors Full Name
+ Yasuoka, Mikako; Muraki, Isao; Imano, Hironori; Jinnouchi, Hiroshige; Kubota, Yasuhiko; Hayama-Terada, Mina; Umesawa, Mitsumasa; Yamagishi, Kazumasa; Ohira, Tetsuya; Kitamura, Akihiko; Okada, Takeo; Kiyama, Masahiko; Iso, Hiroyasu.
+Institution
+ Yasuoka, Mikako. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
+ Muraki, Isao. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
+ Imano, Hironori. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
+ Jinnouchi, Hiroshige. Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan.
+ Kubota, Yasuhiko. Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
+ Hayama-Terada, Mina. Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
+ Hayama-Terada, Mina. Public Health Center of Yao City, Yao, Japan.
+ Umesawa, Mitsumasa. School of Medicine, Dokkyo University, Mibu, Japan.
+ Umesawa, Mitsumasa. Department of Public Health Medicine, Faculty of Medicine, and Health Service Research and Development Center, University of Tsukuba, Tsukuba, Japan.
+ Yamagishi, Kazumasa. Department of Public Health Medicine, Faculty of Medicine, and Health Service Research and Development Center, University of Tsukuba, Tsukuba, Japan.
+ Ohira, Tetsuya. Department of Epidemiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
+ Kitamura, Akihiko. Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
+ Okada, Takeo. Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
+ Kiyama, Masahiko. Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
+ Iso, Hiroyasu. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
+ Iso, Hiroyasu. Department of Public Health Medicine, Faculty of Medicine, and Health Service Research and Development Center, University of Tsukuba, Tsukuba, Japan.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ *Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pa [Pathology]
+ China/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Male
+ Middle Aged
+ *Muscle, Skeletal/pp [Physiopathology]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Risk Factors
+ *Sarcopenia/pp [Physiopathology]
+ *Waist Circumference
+Keyword Heading
+ 2
+ skeletal muscles mass
+ type 2 diabetes mellitus
+ waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although evidence about skeletal muscle mass loss and type 2 diabetes risk has accumulated, little information is available on the combined effect of skeletal muscle mass and abdominal obesity on type 2 diabetes. We examined whether skeletal muscle mass and abdominal obesity were synergistically associated with the prevalence of type 2 diabetes.
+
+ METHODS: Skeletal muscle mass and waist circumference (WC) were measured in 1515 Japanese aged 40 to 69 years. Relative muscle mass was calculated as percentage of total skeletal muscle mass in body weight (SMM%). Type 2 diabetes was identified as fasting serum glucose >=7.0 mmol/L (126 mg/dL), nonfasting serum glucose >=11.1 mmol/L (200 mg/dL), glycosylated hemoglobin >= 6.5%, and/or diabetes medication use.
+
+ RESULTS: The multivariable-adjusted odds ratio (OR) of prevalent diabetes from the lowest to the third quartile of SMM% compared to the highest quartile gradually increased in both sexes. The association between a high WC and prevalent diabetes was similar. The multivariable-adjusted OR (95% confidence intervals) for the prevalence of type 2 diabetes in the low skeletal muscle mass/high WC group was 3.19 (1.78-5.71) for men and 4.46 (2.09-9.51) for women compared with the high skeletal muscle mass/low WC group. The relative excess risk due to interaction was 2.2 (0.5-3.9) in men and 2.8 (0.2-5.3) in women for an excess burden of type 2 diabetes for low skeletal muscle mass and high WC.
+
+ CONCLUSIONS: Low skeletal muscle mass and abdominal obesity were synergistically associated with presence of type 2 diabetes. Copyright © 2020 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
+Other Abstract
+ Publisher
+ : 2 , 2 2 : 1515 40-69 (SMM%) 2 >=7.0 mmol/L(126 mg/dL), >=11.1mmol/L(200mg/dL), >=6 5%, : , (OR) / , / 2 OR 3.19(1.78~5.71), 4.46(2.09~9.51) , 2.2(0.5-3.9), 2.8(0.2-5.3) : 2 .
+ Language: Chinese
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2f1753-0407.13049
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yasuoka&issn=1753-0407&title=Journal+Of+Diabetes&atitle=Joint+impact+of+muscle+mass+and+waist+circumference+on+type+2+diabetes+in+Japanese+middle-aged+adults%3A+The+Circulatory+Risk+in+Communities+Study+%28CIRCS%29.&volume=12&issue=9&spage=677&epage=685&date=2020&doi=10.1111%2F1753-0407.13049&pmid=32372543&sid=OVID:medline
+
+<1344>
+Unique Identifier
+ 32360426
+Title
+ AhR activation defends gut barrier integrity against damage occurring in obesity.
+Source
+ Molecular Metabolism. 39:101007, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Postal BG; Ghezzal S; Aguanno D; Andre S; Garbin K; Genser L; Brot-Laroche E; Poitou C; Soula H; Leturque A; Clement K; Carriere V
+Authors Full Name
+ Postal, Barbara G; Ghezzal, Sara; Aguanno, Doriane; Andre, Sebastien; Garbin, Kevin; Genser, Laurent; Brot-Laroche, Edith; Poitou, Christine; Soula, Hedi; Leturque, Armelle; Clement, Karine; Carriere, Veronique.
+Institution
+ Postal, Barbara G. Cordeliers Research Center, Sorbonne University, Paris Dauphine University 05, INSERM, CNRS, F-75006, Paris, France; Saint-Antoine Research Center, Sorbonne University, INSERM, F-75012, Paris, France.
+ Ghezzal, Sara. Cordeliers Research Center, Sorbonne University, Paris Dauphine University 05, INSERM, CNRS, F-75006, Paris, France.
+ Aguanno, Doriane. Cordeliers Research Center, Sorbonne University, Paris Dauphine University 05, INSERM, CNRS, F-75006, Paris, France; Saint-Antoine Research Center, Sorbonne University, INSERM, F-75012, Paris, France; EPHE, PSL Research University, F-75006, Paris, France.
+ Andre, Sebastien. Sorbonne University, INSERM, NutriOmics Research Unit Paris, F-75013, France.
+ Garbin, Kevin. CHIC Platform of Cordeliers Research Center, Sorbonne University, UPD Univ Paris 05, INSERM, F-75006, Paris, France.
+ Genser, Laurent. Sorbonne University, INSERM, NutriOmics Research Unit Paris, F-75013, France.
+ Brot-Laroche, Edith. Cordeliers Research Center, Sorbonne University, Paris Dauphine University 05, INSERM, CNRS, F-75006, Paris, France.
+ Poitou, Christine. Sorbonne University, INSERM, NutriOmics Research Unit Paris, F-75013, France; Assistance Publique-Hopitaux de Paris, Pitie-Salpetriere Hospital, Nutrition Department, CRNH Ile de France, F-75013, Paris, France.
+ Soula, Hedi. Sorbonne University, INSERM, NutriOmics Research Unit Paris, F-75013, France.
+ Leturque, Armelle. Cordeliers Research Center, Sorbonne University, Paris Dauphine University 05, INSERM, CNRS, F-75006, Paris, France; Sorbonne University, INSERM, NutriOmics Research Unit Paris, F-75013, France.
+ Clement, Karine. Sorbonne University, INSERM, NutriOmics Research Unit Paris, F-75013, France; Assistance Publique-Hopitaux de Paris, Pitie-Salpetriere Hospital, Nutrition Department, CRNH Ile de France, F-75013, Paris, France.
+ Carriere, Veronique. Cordeliers Research Center, Sorbonne University, Paris Dauphine University 05, INSERM, CNRS, F-75006, Paris, France; Saint-Antoine Research Center, Sorbonne University, INSERM, F-75012, Paris, France. Electronic address: veronique.carriere@sorbonne-universite.fr.
+MeSH Subject Headings
+ Adiposity/ge [Genetics]
+ Adult
+ Aged
+ Aged, 80 and over
+ Animals
+ Basic Helix-Loop-Helix Transcription Factors/ge [Genetics]
+ *Basic Helix-Loop-Helix Transcription Factors/me [Metabolism]
+ Biomarkers
+ Cell Line
+ Comorbidity
+ Cytokines/me [Metabolism]
+ Epithelial Cells/me [Metabolism]
+ Female
+ Humans
+ Intestinal Mucosa/im [Immunology]
+ *Intestinal Mucosa/me [Metabolism]
+ Intestinal Mucosa/pa [Pathology]
+ Jejunum/me [Metabolism]
+ Lipid Metabolism
+ MAP Kinase Signaling System
+ Male
+ Mice
+ Middle Aged
+ Models, Biological
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Permeability
+ Receptors, Aryl Hydrocarbon/ge [Genetics]
+ *Receptors, Aryl Hydrocarbon/me [Metabolism]
+ Signal Transduction
+ T-Lymphocyte Subsets/im [Immunology]
+ T-Lymphocyte Subsets/me [Metabolism]
+ Tight Junctions/de [Drug Effects]
+ Tight Junctions/me [Metabolism]
+Keyword Heading
+ Aryl hydrocarbon receptor
+ Cell junction
+ Intestine
+ Permeability
+ Signaling
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Obesity is characterized by systemic and low-grade tissue inflammation. In the intestine, alteration of the intestinal barrier and accumulation of inflammatory cells in the epithelium are important contributors of gut inflammation. Recent studies demonstrated the role of the aryl hydrocarbon receptor (AhR) in the maintenance of immune cells at mucosal barrier sites. A wide range of ligands of external and local origin can activate this receptor. We studied the causal relationship between AhR activation and gut inflammation in obesity.
+
+ METHODS: Jejunum samples from subjects with normal weight and severe obesity were phenotyped according to T lymphocyte infiltration in the epithelium from lamina propria and assayed for the mRNA level of AhR target genes. The effect of an AhR agonist was studied in mice and Caco-2/TC7 cells. AhR target gene expression, permeability to small molecules and ions, and location of cell-cell junction proteins were recorded under conditions of altered intestinal permeability.
+
+ RESULTS: We showed that a low AhR tone correlated with a high inflammatory score in the intestinal epithelium in severe human obesity. Moreover, AhR activation protected junctional complexes in the intestinal epithelium in mice challenged by an oral lipid load. AhR ligands prevented chemically induced damage to barrier integrity and cytokine expression in Caco-2/TC7 cells. The PKC and p38MAPK signaling pathways were involved in this AhR action.
+
+ CONCLUSIONS: The results of these series of human, mouse, and cell culture experiments demonstrate the protective effect of AhR activation in the intestine targeting particularly tight junctions and cytokine expression. We propose that AhR constitutes a valuable target to protect intestinal functions in metabolic diseases, which can be achieved in the future via food or drug ligands. Copyright © 2020 The Author(s). Published by Elsevier GmbH.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (AHR protein, human). 0 (Basic Helix-Loop-Helix Transcription Factors). 0 (Biomarkers). 0 (Cytokines). 0 (Receptors, Aryl Hydrocarbon).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1016%2fj.molmet.2020.101007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Postal&issn=2212-8778&title=Molecular+Metabolism&atitle=AhR+activation+defends+gut+barrier+integrity+against+damage+occurring+in+obesity.&volume=39&issue=&spage=101007&epage=&date=2020&doi=10.1016%2Fj.molmet.2020.101007&pmid=32360426&sid=OVID:medline
+
+<1345>
+Unique Identifier
+ 32358339
+Title
+ The effects of green cardamom supplementation on blood pressure and endothelium function in type 2 diabetic patients: A study protocol for a randomized controlled clinical trial.
+Source
+ Medicine. 99(18):e11005, 2020 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ghazi Zahedi S; Koohdani F; Qorbani M; Siassi F; Keshavarz A; Nasli-Esfahani E; Aghasi M; Khoshamal H; Sotoudeh G
+Authors Full Name
+ Ghazi Zahedi, Shohreh; Koohdani, Fariba; Qorbani, Mostafa; Siassi, Fereydoun; Keshavarz, Ali; Nasli-Esfahani, Ensieh; Aghasi, Mohadeseh; Khoshamal, Hoorieh; Sotoudeh, Gity.
+Institution
+ Ghazi Zahedi, Shohreh. Department of Community Nutrition.
+ Koohdani, Fariba. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran.
+ Qorbani, Mostafa. Noncommunicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, School of Medicine, Alborz University of Medical Sciences, Baghestan Boulevard, Karaj.
+ Siassi, Fereydoun. Department of Community Nutrition.
+ Keshavarz, Ali. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics.
+ Nasli-Esfahani, Ensieh. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Aghasi, Mohadeseh. Department of Community Nutrition.
+ Khoshamal, Hoorieh. Department of Community Nutrition.
+ Sotoudeh, Gity. Department of Community Nutrition.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Pressure/de [Drug Effects]
+ Blood Pressure Determination
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ *Diabetes Mellitus, Type 2/th [Therapy]
+ *Dietary Supplements
+ Double-Blind Method
+ *Elettaria
+ *Endothelium/de [Drug Effects]
+ Female
+ Humans
+ Iran
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+ Randomized Controlled Trials as Topic
+ Treatment Outcome
+Abstract
+ INTRODUCTION: Cardamom possesses antioxidant, anti-inflammation, and blood pressure lowering properties, which might improve endothelial function in type 2 diabetic patients. However, no study has examined the effect of cardamom on diabetic patients. The present study aimed to examine the effects of 10-week green cardamom intake on blood pressure, concentrations of inflammatory and endothelial function biomarkers in type 2 diabetes mellitus patients, and its potential mechanisms.
+
+ METHODS AND ANALYSIS DESIGN: Eighty overweight or obese patients with type 2 diabetes mellitus (aged 30-60 years) will be recruited into the trial and will assign to receive either cardamom (3 g/day, 6 capsules) or placebo (rusk powder, 6 capsules) for a period of 10 weeks. Systolic blood pressure and diastolic blood pressure, asymmetric dimethylarginine, and nitric oxide will be measured. Serum inflammatory markers namely interleukin 6, tumor necrosis factor-alpha, high-sensitivity C-reactive protein, and factors related to endothelial function including intercellular adhesion molecule-1, vascular cell adhesion molecule 1, CD62 antigen-like family member E, and cluster of differentiation 163 will be measured at baseline and at the end of the trial. Sociodemographic, International Physical Activity Questionnaire, and three 24-hour dietary recall questionnaires will be collected for each participant.
+
+ ETHICS AND DISSEMINATION: The study has been approved by The Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.REC.1395.2700). Each participant will sign a written informed consent at the beginning of the study. At the end of the study, results will be published timely manner.
+
+ TRIAL REGISTRATION NUMBER: (http://www.irct.ir, identifier: IRCT-2016042717254N5) Date of registration: 2016-11-23.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial Protocol. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1097%2fMD.0000000000011005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ghazi+Zahedi&issn=0025-7974&title=Medicine&atitle=The+effects+of+green+cardamom+supplementation+on+blood+pressure+and+endothelium+function+in+type+2+diabetic+patients%3A+A+study+protocol+for+a+randomized+controlled+clinical+trial.&volume=99&issue=18&spage=e11005&epage=&date=2020&doi=10.1097%2FMD.0000000000011005&pmid=32358339&sid=OVID:medline
+
+<1346>
+Unique Identifier
+ 32351012
+Title
+ Low urine pH predicts new onset of diabetes mellitus during a 10-year period in men: BOREAS-DM1 study.
+Source
+ Journal of Diabetes Investigation. 11(6):1490-1497, 2020 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Higashiura Y; Tanaka M; Furuhashi M; Koyama M; Ohnishi H; Numata K; Hisasue T; Hanawa N; Moniwa N; Miura T
+Author NameID
+ Furuhashi, Masato; ORCID: https://orcid.org/0000-0002-0145-3541
+Authors Full Name
+ Higashiura, Yukimura; Tanaka, Marenao; Furuhashi, Masato; Koyama, Masayuki; Ohnishi, Hirofumi; Numata, Keita; Hisasue, Takashi; Hanawa, Nagisa; Moniwa, Norihito; Miura, Tetsuji.
+Institution
+ Higashiura, Yukimura. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Tanaka, Marenao. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Tanaka, Marenao. Tanaka Medical Clinic, Sapporo, Japan.
+ Furuhashi, Masato. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Furuhashi, Masato. Department of General Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Koyama, Masayuki. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Koyama, Masayuki. Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Ohnishi, Hirofumi. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Ohnishi, Hirofumi. Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Numata, Keita. Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan.
+ Hisasue, Takashi. Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan.
+ Hanawa, Nagisa. Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo, Japan.
+ Moniwa, Norihito. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Miura, Tetsuji. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+MeSH Subject Headings
+ *Alcohol Drinking/pp [Physiopathology]
+ *Biomarkers/ur [Urine]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/ur [Urine]
+ Follow-Up Studies
+ Humans
+ Hydrogen-Ion Concentration
+ *Hypertension/pp [Physiopathology]
+ Incidence
+ Japan/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Retrospective Studies
+ Risk Factors
+ *Smoking/pp [Physiopathology]
+ Time Factors
+Keyword Heading
+ Bicarbonate ions
+ Nonvolatile acid
+ Urine pH
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: A low level of urine pH (U-pH) has been reported to be associated with metabolic disorders. However, the relationship between the incidence of diabetes mellitus and U-pH has not yet been fully addressed.
+
+ MATERIALS AND METHODS: We investigated the relationship between U-pH and the development of diabetes mellitus during a 10-year period in a general population of individuals who received annual health examinations in 2006 (n = 28,990). After exclusion of individuals with missing data, and those with diabetes mellitus and/or chronic kidney disease at baseline, a total of 12,476 individuals (men/women: 8,027/4,449) who received health examinations at least once during the period from 2007 to 2016 were recruited. The recruited individuals were divided into four groups according to their U-pH levels: groups of U-pH <=5.0, 5.5, 6.0 and >=6.5.
+
+ RESULTS: During a 10-year period, 521 men (6.5%) and 132 women (3.0%) had new onset of diabetes mellitus. The cumulative incidence of diabetes mellitus was 7.5% (men/women: 9.3%/4.4%) per 100 person-years. The hazard ratios (HRs) in the U-pH <=5.0 (HR 1.93) and U-pH 5.5 groups (HR 1.46) were significantly higher than that in the U-pH >=6.5 group as a reference for men, but not for women. After adjustment of age, obesity, fasting glucose, smoking and alcohol drinking habits, family history of diabetes mellitus, and use of drugs for hypertension and dyslipidemia, HR in the U-pH <=5.0 group (HR 1.39) was significantly higher than that in the U-pH >=6.5 group for men, but not for women.
+
+ CONCLUSIONS: Low U-pH predicts new onset of diabetes mellitus in a general population of men. Copyright © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med18&DO=10.1111%2fjdi.13284
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Higashiura&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Low+urine+pH+predicts+new+onset+of+diabetes+mellitus+during+a+10-year+period+in+men%3A+BOREAS-DM1+study.&volume=11&issue=6&spage=1490&epage=1497&date=2020&doi=10.1111%2Fjdi.13284&pmid=32351012&sid=OVID:medline
+
+<1347>
+Unique Identifier
+ 32150549
+Title
+ Fecal microbiota transplantation for the improvement of metabolism in obesity: The FMT-TRIM double-blind placebo-controlled pilot trial.
+Source
+ PLoS Medicine / Public Library of Science. 17(3):e1003051, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yu EW; Gao L; Stastka P; Cheney MC; Mahabamunuge J; Torres Soto M; Ford CB; Bryant JA; Henn MR; Hohmann EL
+Author NameID
+ Gao, Liu; ORCID: https://orcid.org/0000-0002-9263-5614
+ Cheney, Michael C; ORCID: https://orcid.org/0000-0002-5145-6521
+ Torres Soto, Mariam; ORCID: https://orcid.org/0000-0003-3606-2935
+ Ford, Christopher B; ORCID: https://orcid.org/0000-0002-4079-8673
+ Bryant, Jessica A; ORCID: https://orcid.org/0000-0001-8958-4345
+ Henn, Matthew R; ORCID: https://orcid.org/0000-0001-8734-5797
+Authors Full Name
+ Yu, Elaine W; Gao, Liu; Stastka, Petr; Cheney, Michael C; Mahabamunuge, Jasmin; Torres Soto, Mariam; Ford, Christopher B; Bryant, Jessica A; Henn, Matthew R; Hohmann, Elizabeth L.
+Institution
+ Yu, Elaine W. Endocrine Unit, Division of Endocrinology and Metabolism, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
+ Yu, Elaine W. Harvard Medical School, Boston, Massachusetts, United States of America.
+ Gao, Liu. Endocrine Unit, Division of Endocrinology and Metabolism, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
+ Stastka, Petr. Endocrine Unit, Division of Endocrinology and Metabolism, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
+ Cheney, Michael C. Endocrine Unit, Division of Endocrinology and Metabolism, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
+ Mahabamunuge, Jasmin. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
+ Torres Soto, Mariam. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
+ Ford, Christopher B. Seres Therapeutics, Cambridge, Massachusetts, United States of America.
+ Bryant, Jessica A. Seres Therapeutics, Cambridge, Massachusetts, United States of America.
+ Henn, Matthew R. Seres Therapeutics, Cambridge, Massachusetts, United States of America.
+ Hohmann, Elizabeth L. Harvard Medical School, Boston, Massachusetts, United States of America.
+ Hohmann, Elizabeth L. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Boston
+ Double-Blind Method
+ *Energy Metabolism
+ Fecal Microbiota Transplantation/ae [Adverse Effects]
+ *Fecal Microbiota Transplantation
+ Female
+ *Gastrointestinal Microbiome
+ Humans
+ *Insulin Resistance
+ *Intestines/mi [Microbiology]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Obesity/mi [Microbiology]
+ *Obesity/th [Therapy]
+ Pilot Projects
+ Time Factors
+ Treatment Outcome
+Abstract
+ BACKGROUND: There is intense interest about whether modulating gut microbiota can impact systemic metabolism. We investigated the safety of weekly oral fecal microbiota transplantation (FMT) capsules from healthy lean donors and their ability to alter gut microbiota and improve metabolic outcomes in patients with obesity.
+
+ METHODS AND FINDINGS: FMT-TRIM was a 12-week double-blind randomized placebo-controlled pilot trial of oral FMT capsules performed at a single US academic medical center. Between August 2016 and April 2018, we randomized 24 adults with obesity and mild-moderate insulin resistance (homeostatic model assessment of insulin resistance [HOMA-IR] between 2.0 and 8.0) to weekly healthy lean donor FMT versus placebo capsules for 6 weeks. The primary outcome, assessed by intention to treat, was change in insulin sensitivity between 0 and 6 weeks as measured by hyperinsulinemic euglycemic clamps. Additional metabolic parameters were evaluated at 0, 6, and 12 weeks, including HbA1c, body weight, body composition by dual-energy X-ray absorptiometry, and resting energy expenditure by indirect calorimetry. Fecal samples were serially collected and evaluated via 16S V4 rRNA sequencing. Our study population was 71% female, with an average baseline BMI of 38.8 +/- 6.7 kg/m2 and 41.3 +/- 5.1 kg/m2 in the FMT and placebo groups, respectively. There were no statistically significant improvements in insulin sensitivity in the FMT group compared to the placebo group (+5% +/- 12% in FMT group versus -3% +/- 32% in placebo group, mean difference 9%, 95% CI -5% to 28%, p = 0.16). There were no statistically significant differences between groups for most of the other secondary metabolic outcomes, including HOMA-IR (mean difference 0.2, 95% CI -0.9 to 0.9, p = 0.96) and body composition (lean mass mean difference -0.1 kg, 95% CI -1.9 to 1.6 kg, p = 0.87; fat mass mean difference 1.2 kg, 95% CI -0.6 to 3.0 kg, p = 0.18), over the 12-week study. We observed variable engraftment of donor bacterial groups among FMT recipients, which persisted throughout the 12-week study. There were no significant differences in adverse events (AEs) (10 versus 5, p = 0.09), and no serious AEs related to FMT. Limitations of this pilot study are the small sample size, inclusion of participants with relatively mild insulin resistance, and lack of concurrent dietary intervention.
+
+ CONCLUSIONS: Weekly administration of FMT capsules in adults with obesity results in gut microbiota engraftment in most recipients for at least 12 weeks. Despite engraftment, we did not observe clinically significant metabolic effects during the study.
+
+ TRIAL REGISTRATION: ClinicalTrials.gov NCT02530385.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1371%2fjournal.pmed.1003051
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yu&issn=1549-1277&title=PLoS+Medicine+%2F+Public+Library+of+Science&atitle=Fecal+microbiota+transplantation+for+the+improvement+of+metabolism+in+obesity%3A+The+FMT-TRIM+double-blind+placebo-controlled+pilot+trial.&volume=17&issue=3&spage=e1003051&epage=&date=2020&doi=10.1371%2Fjournal.pmed.1003051&pmid=32150549&sid=OVID:medline
+
+<1348>
+Unique Identifier
+ 32201580
+Title
+ Effects of spirulina on weight loss and blood lipids: a review. [Review]
+Source
+ Open Heart. 7(1):e001003, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ DiNicolantonio JJ; Bhat AG; OKeefe J
+Author NameID
+ DiNicolantonio, James J; ORCID: https://orcid.org/0000-0002-7888-1528
+ OKeefe, James; ORCID: https://orcid.org/0000-0002-3376-5822
+Authors Full Name
+ DiNicolantonio, James J; Bhat, Anusha G; OKeefe, James.
+Institution
+ DiNicolantonio, James J. Mid America Heart Institute, Kansas, Kansas, USA.
+ Bhat, Anusha G. Department of Internal Medicine, Baystate Medical Center, Springfield, Massachusetts, USA.
+ Bhat, Anusha G. Department of Public Heath Practice, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States.
+ OKeefe, James. Saint Lukes Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, Missouri, USA.
+MeSH Subject Headings
+ Animals
+ Humans
+ Anti-Obesity Agents/ae [Adverse Effects]
+ Anti-Obesity Agents/tu [Therapeutic Use]
+ *Anti-Obesity Agents
+ Biomarkers/bl [Blood]
+ Dietary Supplements/ae [Adverse Effects]
+ *Dietary Supplements
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/dt [Drug Therapy]
+ *Dyslipidemias
+ Hypolipidemic Agents/ae [Adverse Effects]
+ Hypolipidemic Agents/tu [Therapeutic Use]
+ *Hypolipidemic Agents
+ Lipids/bl [Blood]
+ *Lipids
+ Obesity/di [Diagnosis]
+ Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ *Obesity
+ *Spirulina
+ Treatment Outcome
+ Weight Loss/de [Drug Effects]
+ *Weight Loss
+Keyword Heading
+ lipids
+ spirulina
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Spirulina, a cyanobacteria commonly referred to as a blue-green algae, is one of the oldest lifeforms on Earth. Spirulina grows in both fresh and saltwater sources and is known for its high protein and micronutrient content. This review paper will cover the effects of spirulina on weight loss and blood lipids. The currently literature supports the benefits of spirulina for reducing body fat, waist circumference, body mass index and appetite and shows that spirulina has significant benefits for improving blood lipids. Copyright © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Hypolipidemic Agents). 0 (Lipids).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1136%2fopenhrt-2018-001003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=DiNicolantonio&issn=2053-3624&title=Open+Heart&atitle=Effects+of+spirulina+on+weight+loss+and+blood+lipids%3A+a+review.&volume=7&issue=1&spage=e001003&epage=&date=2020&doi=10.1136%2Fopenhrt-2018-001003&pmid=32201580&sid=OVID:medline
+
+<1349>
+Unique Identifier
+ 31926863
+Title
+ Cardiorespiratory Fitness, Body Mass Index, and Markers of Insulin Resistance in Apparently Healthy Women and Men.
+Source
+ American Journal of Medicine. 133(7):825-830.e2, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Clarke SL; Reaven GM; Leonard D; Barlow CE; Haskell WL; Willis BL; DeFina L; Knowles JW; Maron DJ
+Authors Full Name
+ Clarke, Shoa L; Reaven, Gerald M; Leonard, David; Barlow, Carolyn E; Haskell, William L; Willis, Benjamin L; DeFina, Laura; Knowles, Joshua W; Maron, David J.
+Institution
+ Clarke, Shoa L. Division of Cardiovascular Medicine, Stanford University School of Medicine, Calif. Electronic address: shoa@stanford.edu.
+ Reaven, Gerald M. Division of Cardiovascular Medicine, Stanford University School of Medicine, Calif.
+ Leonard, David. The Cooper Institute, Dallas, Tex.
+ Barlow, Carolyn E. The Cooper Institute, Dallas, Tex.
+ Haskell, William L. Stanford Prevention Research Center, Stanford University School of Medicine, Calif.
+ Willis, Benjamin L. The Cooper Institute, Dallas, Tex.
+ DeFina, Laura. The Cooper Institute, Dallas, Tex.
+ Knowles, Joshua W. Division of Cardiovascular Medicine, Stanford University School of Medicine, Calif; Stanford Cardiovascular Institute, Stanford University School of Medicine, Calif; Diabetes Research Center, Stanford University School of Medicine, Calif.
+ Maron, David J. Division of Cardiovascular Medicine, Stanford University School of Medicine, Calif; Stanford Prevention Research Center, Stanford University School of Medicine, Calif; Stanford Cardiovascular Institute, Stanford University School of Medicine, Calif.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ *Cardiorespiratory Fitness/ph [Physiology]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pp [Physiopathology]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Cross-Sectional Studies
+ *Exercise/ph [Physiology]
+ Female
+ Healthy Volunteers
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/rh [Rehabilitation]
+ Retrospective Studies
+ Risk Factors
+ Triglycerides/bl [Blood]
+Keyword Heading
+ Fitness
+ Insulin resistance
+ Lipids
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Insulin resistance may be present in healthy adults and is associated with poor health outcomes. Obesity is a risk factor for insulin resistance, but most obese adults do not have insulin resistance. Fitness may be protective, but the association between fitness, weight, and insulin resistance has not been studied in a large population of healthy adults.
+
+ METHODS: A cross-sectional analysis of cardiorespiratory fitness, body mass index, and markers of insulin resistance was performed. Study participants were enrolled at the Cooper Clinic in Dallas, Texas. The analysis included 19,263 women and 48,433 men with no history of diabetes or cardiovascular disease. Cardiorespiratory fitness was measured using exercise treadmill testing. Impaired fasting glucose (100-125 mg/dL) and elevated fasting triglycerides (>=150 mg/dL) were used as a markers of insulin resistance.
+
+ RESULTS: Among individuals with normal weight, poor fitness was associated with 2.2-fold higher odds of insulin resistance in women (1.4-3.6; P = .001) and 2.8-fold higher odds in men (2.1-3.6; P <.001). The impact of fitness remained significant for overweight and obese individuals, with the highest risk group being the unfit obese. Among obese women, the odds ratio for insulin resistance was 11.0 for fit women (8.7-13.9; P <.001) and 20.3 for unfit women (15.5-26.5; P <.001). Among obese men, the odds ratio for insulin resistance was 7.4 for fit men (6.7-8.2; P < .001) and 12.9 for unfit men (11.4-14.6; P < .001).
+
+ CONCLUSIONS: Independent of weight, poor fitness is associated with risk of insulin resistance. Obese individuals, particularly women, may benefit from the greatest absolute risk reduction by achieving moderate fitness. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.amjmed.2019.11.031
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Clarke&issn=0002-9343&title=American+Journal+of+Medicine&atitle=Cardiorespiratory+Fitness%2C+Body+Mass+Index%2C+and+Markers+of+Insulin+Resistance+in+Apparently+Healthy+Women+and+Men.&volume=133&issue=7&spage=825&epage=830.e2&date=2020&doi=10.1016%2Fj.amjmed.2019.11.031&pmid=31926863&sid=OVID:medline
+
+<1350>
+Unique Identifier
+ 32022993
+Title
+ Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study.
+Source
+ Journal of Diabetes Investigation. 11(5):1163-1169, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kaneko K; Yatsuya H; Li Y; Uemura M; Chiang C; Hirakawa Y; Ota A; Tamakoshi K; Aoyama A
+Author NameID
+ Kaneko, Kayo; ORCID: https://orcid.org/0000-0002-1580-9748
+ Yatsuya, Hiroshi; ORCID: https://orcid.org/0000-0002-6220-9251
+ Li, Yuanying; ORCID: https://orcid.org/0000-0002-4059-6406
+ Hirakawa, Yoshihisa; ORCID: https://orcid.org/0000-0001-8483-5053
+ Ota, Atsuhiko; ORCID: https://orcid.org/0000-0001-6452-1823
+ Aoyama, Atsuko; ORCID: https://orcid.org/0000-0003-2717-4919
+Authors Full Name
+ Kaneko, Kayo; Yatsuya, Hiroshi; Li, Yuanying; Uemura, Mayu; Chiang, Chifa; Hirakawa, Yoshihisa; Ota, Atsuhiko; Tamakoshi, Koji; Aoyama, Atsuko.
+Institution
+ Kaneko, Kayo. Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan.
+ Yatsuya, Hiroshi. Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan.
+ Yatsuya, Hiroshi. Department of Public Health, Fujita Health University School of Medicine, Toyoake, Japan.
+ Li, Yuanying. Department of Public Health, Fujita Health University School of Medicine, Toyoake, Japan.
+ Uemura, Mayu. Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan.
+ Chiang, Chifa. Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan.
+ Hirakawa, Yoshihisa. Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan.
+ Ota, Atsuhiko. Department of Public Health, Fujita Health University School of Medicine, Toyoake, Japan.
+ Tamakoshi, Koji. Department of Nursing, Nagoya University School of Health Sciences, Nagoya, Japan.
+ Aoyama, Atsuko. Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan.
+ Aoyama, Atsuko. Nagoya University of Arts and Sciences, Nissin, Japan.
+MeSH Subject Headings
+ Adult
+ Biomarkers/an [Analysis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ *Fasting
+ Female
+ Follow-Up Studies
+ *Glucose Intolerance/co [Complications]
+ Humans
+ Incidence
+ Japan/ep [Epidemiology]
+ Male
+ *Metabolic Syndrome/co [Complications]
+ Middle Aged
+ *Obesity/co [Complications]
+ Prognosis
+ Prospective Studies
+ Risk Factors
+Keyword Heading
+ Impaired fasting glucose
+ Metabolic syndrome
+ Population attributable fraction and type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: The Japanese government started a nationwide screening program for metabolic syndrome (MetS) to prevent cardiovascular diseases and diabetes in 2008. Although impaired fasting glucose (IFG) is a strong predictor for type 2 diabetes mellitus, the program does not follow up IFG in non-MetS individuals. This study aimed to examine the risk and the population attributable fraction (PAF) of MetS and IFG for incidence of type 2 diabetes mellitus.
+
+ MATERIALS AND METHODS: Japanese workers (3,417 men and 714 women) aged 40-64 years without a history of diabetes were prospectively followed. MetS was defined as either abdominal obesity plus two or more metabolic risk factors, or being overweight in the case of normal waist circumference plus three or more metabolic risk factors. IFG was defined as fasting blood glucose 100-125 mg/dL.
+
+ RESULTS: During a mean 6.3 years, 240 type 2 diabetes mellitus cases were identified. Compared with those without MetS and IFG, the multivariable-adjusted hazard ratios (95% confidence interval) of non-MetS individuals with IFG, MetS individuals without IFG and MetS individuals with IFG for type 2 diabetes mellitus were 4.9 (3.4-7.1), 2.4 (1.6-3.5) and 8.3 (5.9-11.5), respectively. The corresponding PAFs for type 2 diabetes mellitus incidence were 15.6, 9.1 and 29.7%, respectively.
+
+ CONCLUSIONS: IFG represented a higher risk and PAF than MetS for type 2 diabetes mellitus incidence in middle-aged Japanese individuals. The coexistence of MetS and IFG showed the highest risk and PAF for type 2 diabetes mellitus incidence. The current Japanese MetS screening program should be reconsidered to follow up non-MetS individuals with IFG. Copyright © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2fjdi.13230
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kaneko&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Risk+and+population+attributable+fraction+of+metabolic+syndrome+and+impaired+fasting+glucose+for+the+incidence+of+type+2+diabetes+mellitus+among+middle-aged+Japanese+individuals%3A+Aichi+Worker%27s+Cohort+Study.&volume=11&issue=5&spage=1163&epage=1169&date=2020&doi=10.1111%2Fjdi.13230&pmid=32022993&sid=OVID:medline
+
+<1351>
+Unique Identifier
+ 31916414
+Title
+ Differential regulation of hypoxanthine and xanthine by obesity in a general population.
+Source
+ Journal of Diabetes Investigation. 11(4):878-887, 2020 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Furuhashi M; Koyama M; Higashiura Y; Murase T; Nakamura T; Matsumoto M; Sakai A; Ohnishi H; Tanaka M; Saitoh S; Moniwa N; Shimamoto K; Miura T
+Author NameID
+ Furuhashi, Masato; ORCID: https://orcid.org/0000-0002-0145-3541
+Authors Full Name
+ Furuhashi, Masato; Koyama, Masayuki; Higashiura, Yukimura; Murase, Takayo; Nakamura, Takashi; Matsumoto, Megumi; Sakai, Akiko; Ohnishi, Hirofumi; Tanaka, Marenao; Saitoh, Shigeyuki; Moniwa, Norihito; Shimamoto, Kazuaki; Miura, Tetsuji.
+Institution
+ Furuhashi, Masato. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Furuhashi, Masato. Department of General Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Koyama, Masayuki. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Koyama, Masayuki. Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Higashiura, Yukimura. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Murase, Takayo. Sanwa Kagaku Kenkyusho Co., Ltd, Mie, Japan.
+ Nakamura, Takashi. Sanwa Kagaku Kenkyusho Co., Ltd, Mie, Japan.
+ Matsumoto, Megumi. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Sakai, Akiko. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Ohnishi, Hirofumi. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Ohnishi, Hirofumi. Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Tanaka, Marenao. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Saitoh, Shigeyuki. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Saitoh, Shigeyuki. Division of Medical and Behavioral Subjects, Department of Nursing, Sapporo Medical University School of Health Sciences, Sapporo, Japan.
+ Moniwa, Norihito. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Shimamoto, Kazuaki. Japan Health Care College, Sapporo, Japan.
+ Miura, Tetsuji. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Aged
+ Alanine Transaminase/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Enzyme Inhibitors/pd [Pharmacology]
+ Female
+ Humans
+ Hyperuricemia/me [Metabolism]
+ *Hypoxanthine/me [Metabolism]
+ Japan
+ Liver/me [Metabolism]
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+ Regression Analysis
+ Signal Transduction/ph [Physiology]
+ Triglycerides/me [Metabolism]
+ *Xanthine/me [Metabolism]
+ *Xanthine Dehydrogenase/bl [Blood]
+Keyword Heading
+ Purine metabolism
+ Salvage pathway
+ Xanthine oxidoreductase
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species. Plasma XOR activity is a metabolic biomarker associated with obesity, hyperuricemia, liver dysfunction and insulin resistance. However, it has recently been reported that XOR activity in fat tissue is low in humans, unlike in rodents, and that hypoxanthine is secreted from human fat tissue.
+
+ MATERIALS AND METHODS: The associations of obesity with hypoxanthine, xanthine and plasma XOR activity were investigated in 484 participants (men/women: 224/260) of the Tanno-Sobetsu Study.
+
+ RESULTS: Levels of hypoxanthine, xanthine and plasma XOR activity were significantly higher in men than in women. In 59 participants with hyperuricemia, 11 (men/women: 11/0) participants were being treated with an XOR inhibitor and had a significantly higher level of xanthine, but not hypoxanthine, than that in participants without treatment. In all of the participants, hypoxanthine concentration in smokers was significantly higher than that in non-smokers. Stepwise and multivariate regression analyses showed that body mass index, smoking habit and xanthine were independent predictors of hypoxanthine after adjustment of age, sex and use of antihyperuricemic drugs. Whereas, alanine transaminase, hypoxanthine and plasma XOR activity were independent predictors for xanthine, and alanine transaminase, triglycerides and xanthine were independent predictors for plasma XOR activity.
+
+ CONCLUSIONS: The concentration of hypoxanthine, but not that of xanthine, is independently associated with obesity and smoking habit, indicating differential regulation of hypoxanthine and xanthine in a general population. Copyright © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Enzyme Inhibitors). 0 (Triglycerides). 1AVZ07U9S7 (Xanthine). 2TN51YD919 (Hypoxanthine). EC 1-17-1-4 (Xanthine Dehydrogenase). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2fjdi.13207
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Furuhashi&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Differential+regulation+of+hypoxanthine+and+xanthine+by+obesity+in+a+general+population.&volume=11&issue=4&spage=878&epage=887&date=2020&doi=10.1111%2Fjdi.13207&pmid=31916414&sid=OVID:medline
+
+<1352>
+Unique Identifier
+ 32337295
+Title
+ Elevated Serum Level of Cytokeratin 18 M65ED Is an Independent Indicator of Cardiometabolic Disorders.
+Source
+ Journal of Diabetes Research. 2020:5198359, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Qian L; Zhang L; Wu L; Zhang J; Fang Q; Hou X; Gao Q; Li H; Jia W
+Author NameID
+ Fang, Qichen; ORCID: https://orcid.org/0000-0002-3805-4050
+ Li, Huating; ORCID: https://orcid.org/0000-0003-0526-5545
+ Jia, Weiping; ORCID: https://orcid.org/0000-0002-6244-2168
+Authors Full Name
+ Qian, Lingling; Zhang, Lei; Wu, Liang; Zhang, Jing; Fang, Qichen; Hou, Xuhong; Gao, Qiongmei; Li, Huating; Jia, Weiping.
+Institution
+ Qian, Lingling. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+ Qian, Lingling. Department of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
+ Zhang, Lei. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+ Wu, Liang. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+ Zhang, Jing. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+ Fang, Qichen. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+ Hou, Xuhong. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+ Gao, Qiongmei. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+ Li, Huating. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+ Jia, Weiping. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai 200233, China.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Cell Death/ph [Physiology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Dyslipidemias/bl [Blood]
+ *Dyslipidemias/di [Diagnosis]
+ Female
+ Humans
+ Hypertension/bl [Blood]
+ *Hypertension/di [Diagnosis]
+ *Keratin-18/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+Abstract
+ BACKGROUND: Recent studies have suggested that cell death might be involved in the pathophysiology of metabolic disorders. The cytokeratin 18 (CK18) fragment, as a cell death marker, plays an important role in nonalcoholic fatty liver disease (NAFLD). However, only a limited number of studies have found elevated serum levels of CK18 in patients with type 2 diabetes. Moreover, no studies have been conducted yet to investigate the role of CK18 in hypertension or dyslipidemia. In particular, CK18 M65ED is a more sensitive marker of cell death, and its role in cardiometabolic disorders has not been revealed yet.
+
+ METHODS: A total of 588 subjects were enrolled from the local communities of Shanghai. Serum CK18 M65ED were determined using the enzyme-linked immunosorbent assay. A cardiometabolic disorder was identified by the presence of at least one of the components including overweight or central obesity, diabetes, dyslipidemia, and hypertension.
+
+ RESULTS: Subjects with cardiometabolic disorders exhibited significantly higher serum levels of CK18 M65ED than those without cardiometabolic disorders (197.36 (121.13-354.50) U/L versus 83.85 (52.80-153.75) U/L, respectively, P < 0.001). Increased serum CK18 M65ED quartiles were associated with the increased prevalence of cardiometabolic disorders and its components (P < 0.001 for all components). Multiple stepwise regression analysis also revealed that diastolic blood pressure, glycated hemoglobin A1c, alanine transaminase, and high-density lipoprotein cholesterol were independently correlated with serum CK18 M65ED levels (all P < 0.01). In addition, logistic regression analysis showed that the serum CK18 M65ED levels were positively correlated with cardiometabolic disorders and in an independent manner. Further, CK18 M65ED was revealed to be an indicator of cardiometabolic disorders in a NAFLD-independent manner.
+
+ CONCLUSIONS: Elevated levels of CK18 M65ED, a sensitive cell death marker, were independently and positively correlated with cardiometabolic disorders, even after the adjustment for the presence of NAFLD and other cardiovascular risk factors. Copyright © 2020 Lingling Qian et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Keratin-18).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1155%2f2020%2f5198359
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Qian&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=Elevated+Serum+Level+of+Cytokeratin+18+M65ED+Is+an+Independent+Indicator+of+Cardiometabolic+Disorders.&volume=2020&issue=&spage=5198359&epage=&date=2020&doi=10.1155%2F2020%2F5198359&pmid=32337295&sid=OVID:medline
+
+<1353>
+Unique Identifier
+ 32218297
+Title
+ Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model.
+Source
+ Molecules. 25(7), 2020 Mar 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gutierrez G; Giraldo-Davila D; Combariza MY; Holzgrabe U; Tabares-Guevara JH; Ramirez-Pineda JR; Acin S; Munoz DL; Montoya G; Balcazar N
+Authors Full Name
+ Gutierrez, Gustavo; Giraldo-Davila, Deisy; Combariza, Marianny Y; Holzgrabe, Ulrike; Tabares-Guevara, Jorge Humberto; Ramirez-Pineda, Jose Robinson; Acin, Sergio; Munoz, Diana Lorena; Montoya, Guillermo; Balcazar, Norman.
+Institution
+ Gutierrez, Gustavo. Natural Sciences School, Pharmaceutical Sciences Department, Universidad Icesi, Cali 760031, Colombia.
+ Giraldo-Davila, Deisy. School of Chemistry, Industrial University of Santander, Bucaramanga 680003, Santander, Colombia.
+ Combariza, Marianny Y. School of Chemistry, Industrial University of Santander, Bucaramanga 680003, Santander, Colombia.
+ Holzgrabe, Ulrike. University of Wurzburg, Institute for Pharmacy and Food Chemistry, 97074 Wurzburg, Germany.
+ Tabares-Guevara, Jorge Humberto. Grupo Inmunomodulacion, School of Medicine, Universidad de Antioquia, Medellin 050010, Antioquia, Colombia.
+ Ramirez-Pineda, Jose Robinson. Grupo Inmunomodulacion, School of Medicine, Universidad de Antioquia, Medellin 050010, Antioquia, Colombia.
+ Ramirez-Pineda, Jose Robinson. Department of Physiology and Biochemistry, School of Medicine, Universidad de Antioquia, Carrera 51D N 62-29, Medellin 050010, Colombia.
+ Acin, Sergio. Department of Physiology and Biochemistry, School of Medicine, Universidad de Antioquia, Carrera 51D N 62-29, Medellin 050010, Colombia.
+ Acin, Sergio. GENMOL Group. Sede de Investigacion Universitaria, Universidad de Antioquia, Calle 62 # 52-59, Medellin 050010, Colombia.
+ Munoz, Diana Lorena. GENMOL Group. Sede de Investigacion Universitaria, Universidad de Antioquia, Calle 62 # 52-59, Medellin 050010, Colombia.
+ Montoya, Guillermo. Natural Sciences School, Pharmaceutical Sciences Department, Universidad Icesi, Cali 760031, Colombia.
+ Balcazar, Norman. Department of Physiology and Biochemistry, School of Medicine, Universidad de Antioquia, Carrera 51D N 62-29, Medellin 050010, Colombia.
+ Balcazar, Norman. GENMOL Group. Sede de Investigacion Universitaria, Universidad de Antioquia, Calle 62 # 52-59, Medellin 050010, Colombia.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ *Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ Carbohydrate Metabolism/de [Drug Effects]
+ Diet, High-Fat
+ Disease Models, Animal
+ Gene Expression Regulation/de [Drug Effects]
+ Insulin Secretion/de [Drug Effects]
+ Liver/de [Drug Effects]
+ Liver/pa [Pathology]
+ Mice
+ Obesity/bl [Blood]
+ Obesity/dt [Drug Therapy]
+ *Obesity/im [Immunology]
+ *Obesity/me [Metabolism]
+ Organ Size/de [Drug Effects]
+ Triterpenes/ch [Chemistry]
+ Triterpenes/ip [Isolation & Purification]
+ Triterpenes/pd [Pharmacology]
+ *Triterpenes/tu [Therapeutic Use]
+Keyword Heading
+ Cecropia telenitida
+ serjanic acid
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triterpenes). 0 (serjanic acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fmolecules25071486
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gutierrez&issn=1420-3049&title=Molecules&atitle=Serjanic+Acid+Improves+Immunometabolic+Markers+in+a+Diet-Induced+Obesity+Mouse+Model.&volume=25&issue=7&spage=1486&epage=&date=2020&doi=10.3390%2Fmolecules25071486&pmid=32218297&sid=OVID:medline
+
+<1354>
+Unique Identifier
+ 32119801
+Title
+ High-Risk Atherosclerosis and Metabolic Phenotype: The Roles of Ectopic Adiposity, Atherogenic Dyslipidemia, and Inflammation. [Review]
+Source
+ Metabolic Syndrome & Related Disorders. 18(4):176-185, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lechner K; McKenzie AL; Krankel N; Von Schacky C; Worm N; Nixdorff U; Lechner B; Scherr J; Weingartner O; Krauss RM
+Authors Full Name
+ Lechner, Katharina; McKenzie, Amy L; Krankel, Nicolle; Von Schacky, Clemens; Worm, Nicolai; Nixdorff, Uwe; Lechner, Benjamin; Scherr, Johannes; Weingartner, Oliver; Krauss, Ronald M.
+Institution
+ Lechner, Katharina. Department of Prevention, Rehabilitation and Sports Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
+ Lechner, Katharina. DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
+ McKenzie, Amy L. Virta Health, San Francisco, California, USA.
+ Krankel, Nicolle. Klinik Fur Kardiologie, Campus Benjamin Steglitz, Charite-Universitatsmedizin Berlin, Berlin, Germany.
+ Krankel, Nicolle. DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
+ Von Schacky, Clemens. Preventive Cardiology, Ludwig-Maximilians University, Munich, Germany.
+ Von Schacky, Clemens. Omegametrix, Martinsried, Germany.
+ Worm, Nicolai. German University for Prevention and Health Care Management, Saarbrucken, Germany.
+ Nixdorff, Uwe. European Prevention Center, Dusseldorf, Germany.
+ Lechner, Benjamin. Department of Internal Medicine IV, Ludwig-Maximilians University, Munich, Germany.
+ Scherr, Johannes. Department of Prevention, Rehabilitation and Sports Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
+ Scherr, Johannes. University Center for Prevention and Sports Medicine, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
+ Weingartner, Oliver. Klinik Fur Innere Medizin I, Universitatsklinikum Jena, Jena, Germany.
+ Krauss, Ronald M. University of California, San Francisco, San Francisco, California, USA.
+MeSH Subject Headings
+ *Adiposity/ph [Physiology]
+ Atherosclerosis/di [Diagnosis]
+ Atherosclerosis/ep [Epidemiology]
+ *Atherosclerosis/et [Etiology]
+ Atherosclerosis/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Cardiometabolic Risk Factors
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ Choristoma/co [Complications]
+ Choristoma/ep [Epidemiology]
+ Choristoma/pa [Pathology]
+ *Dyslipidemias/co [Complications]
+ Dyslipidemias/ep [Epidemiology]
+ Dyslipidemias/me [Metabolism]
+ Dyslipidemias/pa [Pathology]
+ Humans
+ *Inflammation/co [Complications]
+ Inflammation/ep [Epidemiology]
+ Inflammation/me [Metabolism]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Phenotype
+ Risk Factors
+Keyword Heading
+ atherosclerosis
+ dyslipidemia
+ ectopic adipose tissue
+ inflammation
+ lifestyle
+ metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Current algorithms for assessing risk of atherosclerotic cardiovascular disease (ASCVD) and, in particular, the reliance on low-density lipoprotein (LDL) cholesterol in conditions where this measurement is discordant with apoB and LDL-particle concentrations fail to identify a sizeable part of the population at high risk for adverse cardiovascular events. This results in missed opportunities for ASCVD prevention, most notably in those with metabolic syndrome, prediabetes, and diabetes. There is substantial evidence that accumulation of ectopic fat and associated metabolic traits are markers for and pathogenic components of high-risk atherosclerosis. Conceptually, the subset of advanced lesions in high-risk atherosclerosis that triggers vascular complications is closely related to a set of coordinated high-risk traits clustering around a distinct metabolic phenotype. A key feature of this phenotype is accumulation of ectopic fat, which, coupled with age-related muscle loss, creates a milieu conducive for the development of ASCVD: atherogenic dyslipidemia, nonresolving inflammation, endothelial dysfunction, hyperinsulinemia, and impaired fibrinolysis. Sustained vascular inflammation, a hallmark of high-risk atherosclerosis, impairs plaque stabilization in this phenotype. This review describes how metabolic and inflammatory processes that are promoted in large measure by ectopic adiposity, as opposed to subcutaneous adipose tissue, relate to the pathogenesis of high-risk atherosclerosis. Clinical biomarkers indicative of these processes provide incremental information to standard risk factor algorithms and advanced lipid testing identifies atherogenic lipoprotein patterns that are below the discrimination level of standard lipid testing. This has the potential to enable improved identification of high-risk patients who are candidates for therapeutic interventions aimed at prevention of ASCVD.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1089%2fmet.2019.0115
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lechner&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=High-Risk+Atherosclerosis+and+Metabolic+Phenotype%3A+The+Roles+of+Ectopic+Adiposity%2C+Atherogenic+Dyslipidemia%2C+and+Inflammation.&volume=18&issue=4&spage=176&epage=185&date=2020&doi=10.1089%2Fmet.2019.0115&pmid=32119801&sid=OVID:medline
+
+<1355>
+Unique Identifier
+ 32070285
+Title
+ Whole grain food diet slightly reduces cardiovascular risks in obese/overweight adults: a systematic review and meta-analysis.
+Source
+ BMC Cardiovascular Disorders. 20(1):82, 2020 02 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang W; Li J; Chen X; Yu M; Pan Q; Guo L
+Author NameID
+ Guo, Lixin; ORCID: https://orcid.org/0000-0002-5896-2793
+Authors Full Name
+ Wang, Weihao; Li, Jianan; Chen, Xiaoxi; Yu, Miao; Pan, Qi; Guo, Lixin.
+Institution
+ Wang, Weihao. Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
+ Li, Jianan. Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
+ Chen, Xiaoxi. Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
+ Yu, Miao. Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
+ Pan, Qi. Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. panqi621@126.com.
+ Guo, Lixin. Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. glxwork2016@163.com.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/pp [Physiopathology]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ *Diet, Healthy
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Nutritive Value
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Protective Factors
+ Risk Assessment
+ Risk Factors
+ *Risk Reduction Behavior
+ Treatment Outcome
+ *Weight Loss
+ *Whole Grains
+Keyword Heading
+ Body weight
+ Cardiovascular risk factors
+ Overweight adults
+ Systematic review
+ Whole grain food
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The effects of whole grain diet on cardiovascular risks in obese and overweight adults is not well established. Our goal was to conduct a systematic review and meta-analysis on the effect of whole grain diet on cardiovascular risks in obese/overweight adults.
+
+ METHODS: PubMed, Embase and Cochrane were systematically scanned for randomized controlled trials (RCTs), and studies were selected based on certain inclusion and exclusion criteria. The primary outcome was the effectiveness of whole grain food consumption in reducing body weight. The secondary outcomes were the effect of whole grain food consumption on cardiovascular disease (CVD) risk factors including plasma low-density lipoprotein cholesterol (LDL-C), insulin resistance index, blood pressure, body mass index (BMI), C-reactive protein (CRP), and waist circumference in obese/overweight adults.
+
+ RESULTS: Our results showed that whole grain consumption was associated with lower body weight (mean difference (MD) = - 0.5, 95% confidence intervals (CI) [- 0.74, 0.25], I2 = 35%, P < 0.0001) and lower CRP (MD = -0.36, 95% CI [- 0.54, - 0.18], I2 = 69%, P < 0.0001), compared with the control group. However, there were no significant differences in LDL-C (MD = -0.08, 95% CI [- 0.16, 0.00], I2 = 27%, P = 0.05), waist circumference (MD = -0.12, 95% CI [- 0.92, 0.68], I2 = 44%, P = 0.76), systolic blood pressure (MD = -0.11, 95% CI [- 1.55, 1.33], I2 = 3%, P = 0.88), diastolic blood pressure (MD = -0.44, 95% CI [- 1.44, 0.57], I2 = 15%, P = 0.39), and fasting glucose (MD = -0.05, 95% CI [- 0.12, 0.01], I2 = 31%, P = 0.11) between the two groups.
+
+ CONCLUSION: This study suggests that whole grain food consumption can slightly reduce body weight and CRP in obese/overweight population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12872-020-01337-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Whole+grain+food+diet+slightly+reduces+cardiovascular+risks+in+obese%2Foverweight+adults%3A+a+systematic+review+and+meta-analysis.&volume=20&issue=1&spage=82&epage=&date=2020&doi=10.1186%2Fs12872-020-01337-z&pmid=32070285&sid=OVID:medline
+
+<1356>
+Unique Identifier
+ 32019489
+Title
+ Dietary quality indices modifies the effects of melanocortin-4 receptor (MC4R) rs17782313 polymorphism on cardio-metabolic risk factors and hypothalamic hormones in obese adults.
+Source
+ BMC Cardiovascular Disorders. 20(1):57, 2020 02 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khodarahmi M; Kahroba H; Jafarabadi MA; Mesgari-Abbasi M; Farhangi MA
+Author NameID
+ Farhangi, Mahdieh Abbasalizad; ORCID: https://orcid.org/0000-0002-7036-6900
+Authors Full Name
+ Khodarahmi, Mahdieh; Kahroba, Houman; Jafarabadi, Mohammad Asghari; Mesgari-Abbasi, Mehran; Farhangi, Mahdieh Abbasalizad.
+Institution
+ Khodarahmi, Mahdieh. Student Research Committee, Department of Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Kahroba, Houman. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Jafarabadi, Mohammad Asghari. Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Jafarabadi, Mohammad Asghari. Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Mesgari-Abbasi, Mehran. Nutrition Research Center, Tabriz University of Medical Sciences, Attar-neishabouri Ave, Golgasht St, Tabriz, 5165665931, Iran.
+ Farhangi, Mahdieh Abbasalizad. Nutrition Research Center, Tabriz University of Medical Sciences, Attar-neishabouri Ave, Golgasht St, Tabriz, 5165665931, Iran. Abbasalizad_m@yahoo.com.
+MeSH Subject Headings
+ Adult
+ *Agouti-Related Protein/bl [Blood]
+ Appetite Regulation
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Cholesterol, LDL/bl [Blood]
+ Cross-Sectional Studies
+ *Diet, Healthy
+ Feeding Behavior
+ Female
+ Gene-Environment Interaction
+ Humans
+ Iran
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ge [Genetics]
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ *Nutritive Value
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ Patient Compliance
+ *Polymorphism, Single Nucleotide
+ *Receptor, Melanocortin, Type 4/ge [Genetics]
+ Risk Assessment
+ Risk Factors
+ Young Adult
+ *alpha-MSH/bl [Blood]
+Keyword Heading
+ Cardio-metabolic risk
+ Diet quality
+ Gene-diet interaction
+ MC4R
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although the Melanocortin-4 Receptor (MC4R) gene rs17782313 C/T has been consistently related to obesity risk, the interaction between MC4R polymorphism and diet quality indices on cardio-metabolic risk factors has not yet investigated. Therefore we aimed to test this hypothesis.
+
+ METHODS: This cross-sectional study recruited 188 (96 males and 92 females) healthy obese adults aged 20-50 years. Diet quality indices including Healthy Eating Index-2015 (HEI-2015) and Diet Quality Index-International (DQI-I) were constructed using data from a validated food frequency questionnaire. MC4R s17782313 were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The interaction between MC4R polymorphism and diet quality indices was tested by Analysis of covariance (ANCOVA) multivariate interaction model.
+
+ RESULTS: There were significant gene-diet interactions between rs17782313 and HEI-2015 (P Interaction < 0.05) in modulating low-density lipoprotein cholesterol (LDL-C) levels among female group; rare allele heterozygotes of rs17782313 had highest mean of LDL-C concentration when placed in second tertile of HEI (P < 0.05). Moreover, rs17782313 and both indices (HEI and DQI-I) had significant interaction on serum glucose concentrations, systolic and diastolic blood pressure (SBP, DBP) in males (P Interaction < 0.05); when adherence to these indices was low, the obesity risk allele was associated with serum glucose concentrations, SBP and DBP. These gene-diet interactions remained significant even after adjustment for potential confounders.
+
+ CONCLUSION: Our study showed that MC4R rs17782313 interacts with adherence to the dietary quality indices (HEI and DQI-I) to influence several cardio-metabolic risk factors in obese male and females. Further large prospective studies are warranted to confirm our findings.
+Registry Number/Name of Substance
+ 0 (AGRP protein, human). 0 (Agouti-Related Protein). 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, LDL). 0 (MC4R protein, human). 0 (Receptor, Melanocortin, Type 4). 581-05-5 (alpha-MSH).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12872-020-01366-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khodarahmi&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Dietary+quality+indices+modifies+the+effects+of+melanocortin-4+receptor+%28MC4R%29+rs17782313+polymorphism+on+cardio-metabolic+risk+factors+and+hypothalamic+hormones+in+obese+adults.&volume=20&issue=1&spage=57&epage=&date=2020&doi=10.1186%2Fs12872-020-01366-8&pmid=32019489&sid=OVID:medline
+
+<1357>
+Unique Identifier
+ 31618136
+Title
+ Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases. [Review]
+Source
+ Metabolic Syndrome & Related Disorders. 18(1):10-30, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Parsanathan R; Jain SK
+Authors Full Name
+ Parsanathan, Rajesh; Jain, Sushil K.
+Institution
+ Parsanathan, Rajesh. Department of Pediatrics and Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana.
+ Jain, Sushil K. Department of Pediatrics and Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana.
+MeSH Subject Headings
+ *Biomarkers/an [Analysis]
+ *Cardiovascular Diseases/ge [Genetics]
+ Humans
+ *Obesity/ge [Genetics]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ cardiac troponins
+ cardiac-specific biomarkers
+ cardiovascular diseases
+ childhood obesity
+ heart rate variability
+ natriuretic peptides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Cardiovascular disease (CVD) is the leading cause of fatality and disability worldwide regardless of gender. Obesity has reached epidemic proportions in population across different regions. According to epidemiological studies, CVD risk markers in childhood obesity are one of the significant risk factors for adulthood CVD, but have received disproportionally little attention. This review has examined the evidence for the presence of traditional cardiac biomarkers (nonspecific; lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, myoglobulin, glycogen phosphorylase isoenzyme BB, myosin light chains, ST2, and ischemia-modified albumin) and novel emerging cardiac-specific biomarkers (cardiac troponins, natriuretic peptides, heart-type fatty acid-binding protein, and miRNAs). Besides, noninvasive anatomical and electrophysiological markers (carotid intima-media thickness, coronary artery calcification, and heart rate variability) in CVDs and obesity are also discussed. Modifiable and nonmodifiable risk factors associated with metabolic syndrome in the progression of CVD, such as obesity, diabetes, hypertension, dyslipidemia, oxidative stress, inflammation, and adipocytokines are also outlined. These underlying prognostic risk factors predict the onset of future microvascular and macrovascular complications. The understanding of invasive and noninvasive cardiac-specific biomarkers and the risk factors may yield valuable insights into the pathophysiology and prevention of CVD in a high-risk obese population at an early stage.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1089%2fmet.2019.0073
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Parsanathan&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Novel+Invasive+and+Noninvasive+Cardiac-Specific+Biomarkers+in+Obesity+and+Cardiovascular+Diseases.&volume=18&issue=1&spage=10&epage=30&date=2020&doi=10.1089%2Fmet.2019.0073&pmid=31618136&sid=OVID:medline
+
+<1358>
+Unique Identifier
+ 32152169
+Title
+ Actions of annatto-extracted tocotrienol supplementation on obese postmenopausal women: study protocol for a double-blinded, placebo-controlled, randomised trial.
+Source
+ BMJ Open. 10(3):e034338, 2020 03 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aryaie A; Tinsley G; Lee J; Watkins BA; Moore L; Alhaj-Saleh A; Shankar K; Wood SR; Wang R; Shen CL
+Author NameID
+ Shen, Chwan-Li; ORCID: https://orcid.org/0000-0001-9595-6598
+Authors Full Name
+ Aryaie, Amir; Tinsley, Grant; Lee, Jaehoon; Watkins, Bruce A; Moore, Lane; Alhaj-Saleh, Adel; Shankar, Kartik; Wood, Sarah R; Wang, Rui; Shen, Chwan-Li.
+Institution
+ Aryaie, Amir. Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
+ Tinsley, Grant. Kinesiology and Sport Management, Texas Tech University, Lubbock, Texas, USA.
+ Lee, Jaehoon. Educational Psychology and Leadership, Texas Tech University, Lubbock, Texas, USA.
+ Watkins, Bruce A. Nutrition, University of California Davis, Davis, California, USA.
+ Moore, Lane. Kinesiology and Sport Management, Texas Tech University, Lubbock, Texas, USA.
+ Alhaj-Saleh, Adel. Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
+ Shankar, Kartik. Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.
+ Wood, Sarah R. Clinical Research Institutes, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
+ Wang, Rui. Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
+ Shen, Chwan-Li. Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA leslie.shen@ttuhsc.edu.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Bixaceae
+ Body Weights and Measures
+ C-Reactive Protein/an [Analysis]
+ Carnitine O-Palmitoyltransferase/an [Analysis]
+ Carotenoids
+ Double-Blind Method
+ Endocannabinoids/an [Analysis]
+ Fatty Acid Synthases/bl [Blood]
+ Female
+ Humans
+ Leptin/bl [Blood]
+ Lipids/bl [Blood]
+ Middle Aged
+ *Obesity/dt [Drug Therapy]
+ Oxylipins/an [Analysis]
+ Plant Extracts/ad [Administration & Dosage]
+ *Plant Extracts/tu [Therapeutic Use]
+ *Postmenopause
+ Tocotrienols
+ Randomized Controlled Trials as Topic
+Keyword Heading
+ inflammation
+ lipid
+ microbiome
+ tocotrienols
+ women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity is a major health concern in postmenopausal women, and chronic low-grade inflammation contributes to the development of obesity. Cellular studies and high-fat-diet-induced obese mouse model mimicking obesity show the antiobesity effect of annatto-extracted tocotrienols (TT) with antioxidant capability. We aim to assess the safety and efficacy of TT consumption for lipid-related parameters in obese postmenopausal women.
+
+ METHODS AND ANALYSIS: Eligible obese postmenopausal women will be randomly assigned to placebo group (430 mg olive oil) and TT group (DeltaGold Tocotrienol 70%) for 24 weeks. In the present study, the primary outcome is total/regional fat mass and visceral adipose tissue. The secondary outcomes include lipid profile in serum, mRNA expression of fatty acid synthase and carnitine palmitoyltransferase 1A in fat tissue, oxylipins and endocannabinoids in plasma and adipose tissue, abundance and composition of intestinal microbiome in faeces, high-sensitivity C-reactive protein (hs-CRP) in serum and leptin in serum. Every participant will be evaluated at 0 (prior to starting intervention) and 24 weeks of intervention, except for serum lipid profile and hs-CRP at 0, 12 and 24 weeks. 'Intent-to-treat' principle is employed for data analysis. Hierarchical linear modelling is used to estimate the effects of dietary TT supplementation while properly accounting for dependency of data and identified covariates. To our knowledge, this is the first randomised, placebo-controlled, double-blinded study to determine dietary TT supplementation on an obese population. If successful, this study will guide the future efficacy TT interventions and TT can be implemented as an alternative for obese population in antiobesity management.
+
+ ETHICS AND DISSEMINATION: This study has been approved by the Bioethics Committee of the Texas Tech University Health Sciences Center, Lubbock. An informed consent form will be signed by a participant before enrolling in the study. The results from this trial will be actively disseminated through academic conference presentation and peer-reviewed journals.
+
+ TRIAL REGISTRATION NUMBER: NCT03705845. Copyright © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Endocannabinoids). 0 (Leptin). 0 (Lipids). 0 (Oxylipins). 0 (Plant Extracts). 0 (Tocotrienols). 36-88-4 (Carotenoids). 6PQP1V1B6O (annatto). 9007-41-4 (C-Reactive Protein). EC 2-3-1-21 (Carnitine O-Palmitoyltransferase). EC 2-3-1-85 (Fatty Acid Synthases).
+Publication Type
+ Clinical Trial Protocol. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1136%2fbmjopen-2019-034338
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aryaie&issn=2044-6055&title=BMJ+Open&atitle=Actions+of+annatto-extracted+tocotrienol+supplementation+on+obese+postmenopausal+women%3A+study+protocol+for+a+double-blinded%2C+placebo-controlled%2C+randomised+trial.&volume=10&issue=3&spage=e034338&epage=&date=2020&doi=10.1136%2Fbmjopen-2019-034338&pmid=32152169&sid=OVID:medline
+
+<1359>
+Unique Identifier
+ 31729246
+Title
+ Reproducibility of endothelial microparticles in children and adolescents.
+Source
+ Biomarkers in Medicine. 14(1):43-51, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Northrop EF; Milbauer LC; Rudser KD; Fox CK; Solovey AN; Kaizer AM; Hebbel RP; Kelly AS; Ryder JR
+Authors Full Name
+ Northrop, Elise F; Milbauer, Liming C; Rudser, Kyle D; Fox, Claudia K; Solovey, Anna N; Kaizer, Alexander M; Hebbel, Robert P; Kelly, Aaron S; Ryder, Justin R.
+Institution
+ Northrop, Elise F. Division of Biostatistics, School of Public Health, Minneapolis, MN 55455, USA.
+ Milbauer, Liming C. Department of Biochemistry, University of Minnesota, St Paul, MN 55418, USA.
+ Rudser, Kyle D. Division of Biostatistics, School of Public Health, Minneapolis, MN 55455, USA.
+ Rudser, Kyle D. Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Fox, Claudia K. Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Fox, Claudia K. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Solovey, Anna N. Vascular Biology Center, Division of Hematology, Oncology & Transplantation, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Solovey, Anna N. Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Kaizer, Alexander M. Department of Biostatistics & Informatics, Colorado School of Public Health, University of Colorado, Aurora, CO 80045, USA.
+ Hebbel, Robert P. Vascular Biology Center, Division of Hematology, Oncology & Transplantation, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Hebbel, Robert P. Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Kelly, Aaron S. Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Kelly, Aaron S. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Ryder, Justin R. Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+ Ryder, Justin R. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/me [Metabolism]
+ *Blood Platelets/cy [Cytology]
+ Blood Platelets/me [Metabolism]
+ *Cell-Derived Microparticles/ch [Chemistry]
+ Cell-Derived Microparticles/me [Metabolism]
+ Child
+ Cross-Sectional Studies
+ *Endothelium, Vascular/cy [Cytology]
+ Endothelium, Vascular/me [Metabolism]
+ Female
+ Humans
+ Male
+ *Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Reproducibility of Results
+Keyword Heading
+ biomarkers
+ endothelial
+ microparticles
+ obesity
+ reproducibility
+ youth
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aim: We assessed reproducibility of endothelial microparticles (EMPs) enumeration among youth. Methods & results: Four microparticle (MP) indices - total MP per microliter platelet free plasma (PFP), total EMPs per microliter PFP, percent activated EMPs and percent lactadherin positive (LACT[+]) of total EMPs - were measured at two visits (baseline and 7 +/- 3 days follow-up) to determine reproducibility overall and by obesity status. We examined CD31+ or CD144+ with CD41-EMP events of size 0.3-1.0 mum. No statistically significant differences were observed between visits for any of the four MP indices. The within-participant and between-participant coefficient of variation was acceptable (range: 1.13-2.37) with good intraclass-correlation coefficient for all indices except total MP per microliter (range: 0.10-1.00). Conclusion: Total EMPs per microliter PFP, percent-activated EMPs and percent LACT(+) of total EMPs are reproducible among youth.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.2217%2fbmm-2019-0229
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Northrop&issn=1752-0363&title=Biomarkers+in+Medicine&atitle=Reproducibility+of+endothelial+microparticles+in+children+and+adolescents.&volume=14&issue=1&spage=43&epage=51&date=2020&doi=10.2217%2Fbmm-2019-0229&pmid=31729246&sid=OVID:medline
+
+<1360>
+Unique Identifier
+ 32093712
+Title
+ Aberrant expression of miR-214 is associated with obesity-induced insulin resistance as a biomarker and therapeutic.
+Source
+ Diagnostic Pathology. 15(1):18, 2020 Feb 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cheng F; Yuan G; He J; Shao Y; Zhang J; Guo X
+Authors Full Name
+ Cheng, Fangxiao; Yuan, Geheng; He, Jiao; Shao, Yimin; Zhang, Junqing; Guo, Xiaohui.
+Institution
+ Cheng, Fangxiao. Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
+ Yuan, Geheng. Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China. jingjia7149065@163.com.
+ He, Jiao. Department of Endocrinology, Baoding First Central Hispital, Baoding, 071000, Hebei Province, China.
+ Shao, Yimin. Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
+ Zhang, Junqing. Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
+ Guo, Xiaohui. Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China. kuiwei072397654@163.com.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ Female
+ Humans
+ *Insulin Resistance/ge [Genetics]
+ Male
+ Mice
+ *MicroRNAs/ge [Genetics]
+ Obesity/ge [Genetics]
+ Rats, Sprague-Dawley
+Keyword Heading
+ Adipocyte
+ DDP4
+ Insulin resistance
+ MicroRNA-214
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Insulin resistance (IR) in obesity is associated with the occurrence of metabolic and cardiovascular diseases. Dipepidyl peptidase 4 (DPP4) plays a pivotal role during the development of IR, and was found to be a target gene of microRNA-214 (miR-214) in our study. This study sought to assess the expression and clinical value of miR-214 in obese patients with IR, and investigate its therapeutic potential in obese rats and adipocytes with IR.
+
+ METHODS: Serum expression of miR-214 in obese patients with or without IR was estimated by quantitative real-time-PCR. A receiver operating characteristic curve was plotted to evaluate the diagnostic value of miR-214 in the patients. Obesity-induced IR animal and cell models were constructed, and the therapeutic ability of miR-214 was explored.
+
+ RESULTS: Serum expression of miR-214 was decreased in obese patients compared with the healthy controls, and the lowest expression was observed in the cases with IR. Downregulation of miR-214 was significantly correlated with the serum DPP4 levels and HOMA-IR of the patients upon IR conditions, and was demonstrated to perform diagnostic accuracy for distinguishing obese patients with IR from those without IR. In obesity-associated IR animal and cell models, the downregulation of miR-214 was also been detected. According to the measurement of glucose and insulin tolerance and glucose uptake abilities, we found that the overexpression of miR-214 could be used to alleviate IR in the IR models, especially when collaboratively used with DPP4 inhibitor vildagliptin.
+
+ CONCLUSION: All data revealed that miR-214, as a regulator of DPP4, is decreased in obese patients with IR and may serve as a diagnostic biomarker. The upregulation of miR-214 could improve IR in obese rats and adipocytes, indicating that miR-214 has the therapeutic potential for obesity and IR.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN214 microRNA, human). 0 (MicroRNAs). 0 (Mirn214 microRNA, mouse). 0 (Mirn214 microRNA, rat).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs13000-019-0914-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cheng&issn=1746-1596&title=Diagnostic+Pathology&atitle=Aberrant+expression+of+miR-214+is+associated+with+obesity-induced+insulin+resistance+as+a+biomarker+and+therapeutic.&volume=15&issue=1&spage=18&epage=&date=2020&doi=10.1186%2Fs13000-019-0914-1&pmid=32093712&sid=OVID:medline
+
+<1361>
+Unique Identifier
+ 32326626
+Title
+ Dietary Intake of Free Sugars is Associated with Disease Activity and Dyslipidemia in Systemic Lupus Erythematosus Patients.
+Source
+ Nutrients. 12(4), 2020 Apr 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Correa-Rodriguez M; Pocovi-Gerardino G; Callejas-Rubio JL; Rios Fernandez R; Martin-Amada M; Cruz-Caparros MG; Medina-Martinez I; Ortego-Centeno N; Rueda-Medina B
+Author NameID
+ Correa-Rodriguez, Maria; ORCID: https://orcid.org/0000-0001-9165-4349
+ Pocovi-Gerardino, Gabriela; ORCID: https://orcid.org/0000-0002-2720-7461
+ Medina-Martinez, Irene; ORCID: https://orcid.org/0000-0003-1088-0032
+ Rueda-Medina, Blanca; ORCID: https://orcid.org/0000-0002-0263-7000
+Authors Full Name
+ Correa-Rodriguez, Maria; Pocovi-Gerardino, Gabriela; Callejas-Rubio, Jose-Luis; Rios Fernandez, Raquel; Martin-Amada, Maria; Cruz-Caparros, Maria-Gracia; Medina-Martinez, Irene; Ortego-Centeno, Norberto; Rueda-Medina, Blanca.
+Institution
+ Correa-Rodriguez, Maria. Department of Nursing, Health Sciences Faculty, University of Granada (UGR), Avenida de la Ilustracion s/n, 18100 Granada, Spain.
+ Correa-Rodriguez, Maria. Instituto de Investigacion Biosanitaria, IBS, Avda, de Madrid, 15, Pabellon de consultas externas 2, 2 planta, 18012 Granada, Spain.
+ Pocovi-Gerardino, Gabriela. Department of Nursing, Health Sciences Faculty, University of Granada (UGR), Avenida de la Ilustracion s/n, 18100 Granada, Spain.
+ Pocovi-Gerardino, Gabriela. Instituto de Investigacion Biosanitaria, IBS, Avda, de Madrid, 15, Pabellon de consultas externas 2, 2 planta, 18012 Granada, Spain.
+ Callejas-Rubio, Jose-Luis. Unidad de Enfermedades Autoinmunes Sistemicas, Servicio de Medicina Interna, Hospital Universitario San Cecilio, Av, de la Investigacion, s/n, 18016 Granada, Spain.
+ Rios Fernandez, Raquel. Unidad de Enfermedades Autoinmunes Sistemicas, Servicio de Medicina Interna, Hospital Universitario San Cecilio, Av, de la Investigacion, s/n, 18016 Granada, Spain.
+ Martin-Amada, Maria. Unidad de Enfermedades Autoinmunes Sistemicas, Servicio de Medicina Interna, Complejo Hospitalario de Jaen, Av. del Ejercito Espanol, 10, 23007 Jaen, Spain.
+ Cruz-Caparros, Maria-Gracia. Unidad de Enfermedades Autoinmunes Sistemicas, Servicio de Medicina Interna, Hospital de Poniente, Carretera de Almerimar, 31, 04700 El Ejido, Almeria, Spain.
+ Medina-Martinez, Irene. Department of Nursing, Health Sciences Faculty, University of Granada (UGR), Avenida de la Ilustracion s/n, 18100 Granada, Spain.
+ Ortego-Centeno, Norberto. Instituto de Investigacion Biosanitaria, IBS, Avda, de Madrid, 15, Pabellon de consultas externas 2, 2 planta, 18012 Granada, Spain.
+ Ortego-Centeno, Norberto. Unidad de Enfermedades Autoinmunes Sistemicas, Servicio de Medicina Interna, Hospital Universitario San Cecilio, Av, de la Investigacion, s/n, 18016 Granada, Spain.
+ Rueda-Medina, Blanca. Department of Nursing, Health Sciences Faculty, University of Granada (UGR), Avenida de la Ilustracion s/n, 18100 Granada, Spain.
+ Rueda-Medina, Blanca. Instituto de Investigacion Biosanitaria, IBS, Avda, de Madrid, 15, Pabellon de consultas externas 2, 2 planta, 18012 Granada, Spain.
+MeSH Subject Headings
+ Adult
+ Antibodies, Antinuclear/bl [Blood]
+ Biomarkers/bl [Blood]
+ C-Reactive Protein
+ Cardiovascular Diseases/et [Etiology]
+ Complement C3
+ Cross-Sectional Studies
+ DNA/im [Immunology]
+ Diabetes Mellitus
+ *Dietary Sugars/ae [Adverse Effects]
+ Disease Progression
+ *Dyslipidemias/et [Etiology]
+ Female
+ Homocysteine/bl [Blood]
+ Humans
+ Hypertension
+ Lupus Erythematosus, Systemic/di [Diagnosis]
+ *Lupus Erythematosus, Systemic/et [Etiology]
+ Male
+ Middle Aged
+ Obesity
+ Risk Factors
+ Severity of Illness Index
+Keyword Heading
+ autoimmune disease
+ cardiovascular factors
+ free sugars intake
+ inflammation
+ lupus
+ sugar intake
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Diet has been closely associated with inflammatory autoimmune diseases, including systemic lupus erythematosus (SLE). Importantly, the consumption of dietary sugars has been positively linked to elevated levels of some inflammation markers, but the potential role of their consumption on the prognosis of autoimmune diseases has not yet been examined. The aim of this study was to evaluate the association between the dietary intake of free sugars and clinical parameters and cardiovascular (CVD) risk markers in patients with SLE. A cross-sectional study including a total of 193 patients with SLE (aged 48.25 +/- 12.54 years) was conducted. The SLE Disease Activity Index (SLEDAI-2K) and the SDI Damage Index were used to asses disease activity and disease-related damage, respectively. Levels of C-reactive protein (CRP; mg/dL), homocysteine (Hcy; micromol/L), anti-double stranded DNA antibodies (anti-dsDNA) (IU/mL), complement C3 (mg/dL), and complement C4 (mg/dL), among other biochemical markers, were measured. The main factors we considered as risk factors for CVD were obesity, diabetes mellitus, hypertension, and blood lipids. The dietary-intrinsic sugar and added-sugar content participants consumed were obtained via a 24-h patient diary. Significant differences were observed in dietary sugar intake between patients with active and inactive SLE (in grams: 28.31 +/- 24.43 vs. 38.71 +/- 28.87; p = 0.035) and free sugar intake (as a percentage: 6.36 +/- 4.82 vs. 8.60 +/- 5.51; p = 0.020). Linear regression analysis revealed a significant association between free sugars intake (by gram or percentage) and the number of complications (beta (95% CI) = 0.009 (0.001, 0.0018), p = 0.033)); (beta (95% CI) = 0.046 (0.008, 0.084), p = 0.018)), and SLEDAI (beta (95% CI) = 0.017 (0.001, 0.034), p = 0.043)); (beta (95% CI) = 0.086 (0.011, 0.161), p = 0.024)) after adjusting for covariates. Free sugars (g and %) were also associated with the presence of dyslipidaemia (beta (95% CI) = -0.003 (-0.005, 0.000), p = 0.024)) and (beta (95% CI) = -0.015 (-0.028, -0.002), p = 0.021)). Our findings suggest that a higher consumption of free sugars might negatively impact the activity and complications of SLE. However, future longitudinal research on SLE patients, including dietary intervention trials, are necessary to corroborate these preliminary data.
+Registry Number/Name of Substance
+ 0 (Antibodies, Antinuclear). 0 (Biomarkers). 0 (C3 protein, human). 0 (Complement C3). 0 (Dietary Sugars). 0LVT1QZ0BA (Homocysteine). 9007-41-4 (C-Reactive Protein). 9007-49-2 (DNA).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12041094
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Correa-Rodriguez&issn=2072-6643&title=Nutrients&atitle=Dietary+Intake+of+Free+Sugars+is+Associated+with+Disease+Activity+and+Dyslipidemia+in+Systemic+Lupus+Erythematosus+Patients.&volume=12&issue=4&spage=&epage=&date=2020&doi=10.3390%2Fnu12041094&pmid=32326626&sid=OVID:medline
+
+<1362>
+Unique Identifier
+ 32326613
+Title
+ Neurocognitive Inhibitory Control Ability Performance and Correlations with Biochemical Markers in Obese Women.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 17(8), 2020 04 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wen HJ; Tsai CL
+Author NameID
+ Wen, Huei-Jhen; ORCID: https://orcid.org/0000-0003-2213-6841
+ Tsai, Chia-Liang; ORCID: https://orcid.org/0000-0001-6173-2879
+Authors Full Name
+ Wen, Huei-Jhen; Tsai, Chia-Liang.
+Institution
+ Wen, Huei-Jhen. Center of Physical Education, College of Education and Communication, Tzu Chi University, Hualien 970301, Taiwan.
+ Wen, Huei-Jhen. Sports Medicine Center, Tzu Chi Hospital, Hualien 970410, Taiwan.
+ Tsai, Chia-Liang. Institution of Physical Education, Health and Leisure Studies, National Cheng Kung University, Tainan 701401, Taiwan.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ *Electroencephalography
+ *Evoked Potentials
+ Female
+ Humans
+ Obesity/me [Metabolism]
+ Obesity/px [Psychology]
+ *Obesity
+ Reaction Time
+ Stroop Test
+Keyword Heading
+ adiponectin/leptin ratio
+ event-related potential
+ inflammatory cytokine
+ inhibitory control
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Inhibitory control, the ability to suppress prepotent responses and resist irrelevant stimuli, is thought to play a critical role in the maintenance of obesity. However, electrophysiological performance related to different inhibitory control processes and their relationship with motor response inhibition and cognitive interference and potential biochemical mechanisms in middle-aged, obese women are as yet unclear. This work thus compared different neurocognitive Go/Nogo and Stroop task performance in healthy sedentary normal-weight and obese women, as well as their correlation with biochemical markers. Twenty-six healthy, sedentary obese women (obese group) and 26 age-matched (21-45 years old) normal-weight women (control group) were the participants, categorized by body mass index and percentage fat, as measured with dual-energy X-ray absorptiometry. They provided a fasting blood sample and performed two cognitive tasks (i.e., Go/Nogo and Stroop tasks) with concomitant electrophysiological recording. The N2 and P3 waveforms of event-related potential (ERP) were recorded. Although the between-group behavioral performance was comparable, the obese group relative to the control group showed significantly longer N2 latency and smaller P3 amplitude in the Stroop task and smaller N2 and P3 amplitudes in the Go/Nogo task. Significant inflammation response indices (e.g., CRP, leptin, adiponectin/leptin ratio) were observed in the obese group. The Nogo P3 amplitude was significantly correlated with the adiponectin/leptin ratio. These findings indicate that healthy obese women still exhibit deviant neurophysiological performance when performing Go/Nogo and Stroop tasks, where the adiponectin/leptin ratio could be one of the influencing factors for the deficit in neural processes of motor response inhibition.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijerph17082726
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wen&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Neurocognitive+Inhibitory+Control+Ability+Performance+and+Correlations+with+Biochemical+Markers+in+Obese+Women.&volume=17&issue=8&spage=&epage=&date=2020&doi=10.3390%2Fijerph17082726&pmid=32326613&sid=OVID:medline
+
+<1363>
+Unique Identifier
+ 32322021
+Title
+ Telomere shortening associates with elevated insulin and nuchal fat accumulation.
+Source
+ Scientific Reports. 10(1):6863, 2020 04 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mangge H; Herrmann M; Almer G; Zelzer S; Moeller R; Horejsi R; Renner W
+Authors Full Name
+ Mangge, Harald; Herrmann, Markus; Almer, Gunter; Zelzer, Sieglinde; Moeller, Reinhard; Horejsi, Renate; Renner, Wilfried.
+Institution
+ Mangge, Harald. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. harald.mangge@medunigraz.at.
+ Herrmann, Markus. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
+ Almer, Gunter. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
+ Zelzer, Sieglinde. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
+ Moeller, Reinhard. Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation), Medical University of Graz, Graz, Austria.
+ Horejsi, Renate. Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation), Medical University of Graz, Graz, Austria.
+ Renner, Wilfried. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Carotid Intima-Media Thickness
+ Child
+ Female
+ Humans
+ *Insulin/bl [Blood]
+ *Lipogenesis
+ Male
+ Middle Aged
+ *Nuchal Translucency Measurement
+ Obesity/bl [Blood]
+ Obesity/dg [Diagnostic Imaging]
+ *Obesity
+ *Telomere Shortening
+Abstract
+ Obesity and relative leucocyte telomere length (RTL) are both linked to accelerated aging and premature mortality. We examined if nuchal subcutaneous adipose tissue (SAT) thickness, a surrogate marker of central trunk-weighted obesity, is an independent predictor of RTL that provides information beyond BMI, metabolic and inflammatory markers. RTL and nuchal SAT thickness were determined in 362 participants of the STYJOBS/EDECTA study (STYrian Juvenile Obesity Study, Early DEteCTion of atherosclerosis), which included overweight individuals and matched eutrophic controls. Fasting plasma samples were used for the measurement of leptin, resistin, adiponectin, glucose, insulin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), liver enzymes, creatinine, cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, oxidized LDL, triglycerides, homocysteine and uric acid. Furthermore, all participants underwent carotid artery ultrasound. Obese individuals had markedly higher body mass index (BMI), nuchal SAT thickness, hip and waist circumferences and carotid intima media thickness (IMT) than eutrophic controls. In addition, they showed typical biochemical abnormalities related to energy metabolism, systemic inflammation and liver function. RTL was inversely correlated with nuchal SAT thickness, IMT, hs-CRP, alkaline phosphatase, insulin, resistin, and leptin. Positive correlations were seen with homocysteine and creatinine. Stepwise linear regression analyses identified nuchal SAT thickness and insulin as the only significant predictors of RTL. In conclusion, nuchal SAT thickness is a robust predictor of RTL that provides information beyond traditional obesity-related metabolic and inflammatory biomarkers. This suggests an important role of fat depots at the neck for accelerated telomere shortening.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin).
+Publication Type
+ Clinical Trial. Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1038%2fs41598-020-63916-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mangge&issn=2045-2322&title=Scientific+Reports&atitle=Telomere+shortening+associates+with+elevated+insulin+and+nuchal+fat+accumulation.&volume=10&issue=1&spage=6863&epage=&date=2020&doi=10.1038%2Fs41598-020-63916-6&pmid=32322021&sid=OVID:medline
+
+<1364>
+Unique Identifier
+ 32320071
+Title
+ Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti-tumor immunity. [Review]
+Source
+ Immunological Reviews. 295(1):220-239, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sipe LM; Chaib M; Pingili AK; Pierre JF; Makowski L
+Author NameID
+ Pierre, Joseph F; ORCID: https://orcid.org/0000-0002-4248-1290
+ Makowski, Liza; ORCID: https://orcid.org/0000-0002-5337-8037
+Authors Full Name
+ Sipe, Laura M; Chaib, Mehdi; Pingili, Ajeeth K; Pierre, Joseph F; Makowski, Liza.
+Institution
+ Sipe, Laura M. Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Chaib, Mehdi. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Pingili, Ajeeth K. Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Pierre, Joseph F. Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Makowski, Liza. Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Makowski, Liza. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.
+ Makowski, Liza. Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.
+MeSH Subject Headings
+ Animals
+ Bariatric Surgery
+ *Bile Acids and Salts/me [Metabolism]
+ Biomarkers
+ Disease Susceptibility
+ Energy Metabolism/de [Drug Effects]
+ Gastrointestinal Microbiome/im [Immunology]
+ Humans
+ Immune Checkpoint Inhibitors/pd [Pharmacology]
+ Immune Checkpoint Inhibitors/tu [Therapeutic Use]
+ Immune Checkpoint Proteins/me [Metabolism]
+ Immunomodulation/de [Drug Effects]
+ Microbiota/im [Immunology]
+ *Microbiota
+ Neoplasms/co [Complications]
+ Neoplasms/et [Etiology]
+ Neoplasms/me [Metabolism]
+ Neoplasms/pa [Pathology]
+ Obesity/co [Complications]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/su [Surgery]
+ Prognosis
+ Signal Transduction/de [Drug Effects]
+ Treatment Outcome
+Keyword Heading
+ bariatric surgery
+ immunometabolism
+ microbiome
+ mitochondria
+ obesity
+ tumor microenvironment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Bile acids (BAs) are known facilitators of nutrient absorption but recent paradigm shifts now recognize BAs as signaling molecules regulating both innate and adaptive immunity. Bile acids are synthesized from cholesterol in the liver with subsequent microbial modification and fermentation adding complexity to pool composition. Bile acids act on several receptors such as Farnesoid X Receptor and the G protein-coupled BA receptor 1 (TGR5). Interestingly, BA receptors (BARs) are expressed on immune cells and activation either by BAs or BAR agonists modulates innate and adaptive immune cell populations skewing their polarization toward a more tolerogenic anti-inflammatory phenotype. Intriguingly, recent evidence also suggests that BAs promote anti-tumor immune response through activation and recruitment of tumoricidal immune cells such as natural killer T cells. These exciting findings have redefined BA signaling in health and disease wherein they may suppress inflammation on the one hand, yet promote anti-tumor immunity on the other hand. In this review, we provide our readers with the most recent understanding of the interaction of BAs with the host microbiome, their effect on innate and adaptive immunity in health and disease with a special focus on obesity, bariatric surgery-induced weight loss, and immune checkpoint blockade in cancer. Copyright © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers). 0 (Immune Checkpoint Inhibitors). 0 (Immune Checkpoint Proteins).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2fimr.12856
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sipe&issn=0105-2896&title=Immunological+Reviews&atitle=Microbiome%2C+bile+acids%2C+and+obesity%3A+How+microbially+modified+metabolites+shape+anti-tumor+immunity.&volume=295&issue=1&spage=220&epage=239&date=2020&doi=10.1111%2Fimr.12856&pmid=32320071&sid=OVID:medline
+
+<1365>
+Unique Identifier
+ 32315583
+Title
+ Kidney function and glucose metabolism in overweight and obese cats.
+Source
+ Veterinary Quarterly. 40(1):132-139, 2020 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Perez-Lopez L; Boronat M; Melian C; Brito-Casillas Y; Wagner AM
+Authors Full Name
+ Perez-Lopez, L; Boronat, M; Melian, C; Brito-Casillas, Y; Wagner, A M.
+Institution
+ Perez-Lopez, L. Institute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC), Las Palmas, Spain.
+ Boronat, M. Institute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC), Las Palmas, Spain.
+ Boronat, M. Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Spain.
+ Melian, C. Institute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC), Las Palmas, Spain.
+ Melian, C. Veterinary Faculty, Department of Animal Pathology, University of Las Palmas de Gran Canaria, Arucas, Las Palmas, Spain.
+ Brito-Casillas, Y. Institute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC), Las Palmas, Spain.
+ Wagner, A M. Institute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC), Las Palmas, Spain.
+ Wagner, A M. Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Spain.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ Blood Glucose
+ *Cat Diseases/bl [Blood]
+ *Cat Diseases/et [Etiology]
+ Cat Diseases/ur [Urine]
+ Cats
+ Creatinine/ur [Urine]
+ Cross-Sectional Studies
+ Female
+ *Fructosamine/bl [Blood]
+ Kidney Function Tests
+ Male
+ Obesity/co [Complications]
+ *Obesity/ve [Veterinary]
+ Overweight
+ Renal Insufficiency, Chronic/bl [Blood]
+ Renal Insufficiency, Chronic/co [Complications]
+ *Renal Insufficiency, Chronic/ve [Veterinary]
+ Risk Factors
+ Spain
+Keyword Heading
+ Cat
+ active transforming growth factor-beta1
+ diabetes mellitus
+ feline
+ fructosamine
+ metabolic syndrome
+ nephropathy
+ obesity
+ retinol biding protein
+ symmetric dimethyl arginine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: In people, obesity and prediabetes mellitus might predispose to chronic kidney disease (CKD). Aims: To assess the association of overweight [Body condition score (BCS) >5] and glucose metabolism alterations, with established or potential markers of CKD. In addition, fructosamine and fasted blood glucose were compared as predictors of early abnormal glucose metabolism. Methods: 54 clinically healthy cats were included in a cross-sectional study comprising 25 neutered males and 29 (28 neutered) females aged 7.2 (5.5-9.4) years. Two potential markers of CKD, namely urinary free active transforming growth factor-beta1-creatinine ratio and urinary retinol binding protein-creatinine ratio were measured along with other parameters to assess CKD. A receiver operating curve was used to identify the best sensitivity and specificity of fructosamine to identify cats with fasting glucose >6.5 mmol/L. Results: No association was found between BCS and markers of CKD. Fructosamine was greater in cats with fasting glucose >6.5 mmol/L compared to those with fasting glucose <=6.5 mmol/L. A fructosamine concentration >=250 micromol/L was able to detect cats with hyperglycemia with a sensitivity of 77% and a specificity of 65%. Furthermore, fructosamine was more strongly correlated with fasting glucose than albumin-corrected fructosamine (r = 0.43, p = 0.002 vs r = 0.32, p = 0.026). Cats with higher fructosamine had lower serum symmetric dimethylarginine concentrations. Conclusion: The present study does not suggest an effect of obesity on renal function in domestic cats. Clinical relevance: Fructosamine might be of value for the diagnosis of prediabetes mellitus in cats.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 4429-04-3 (Fructosamine). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1080%2f01652176.2020.1759844
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Perez-Lopez&issn=0165-2176&title=Veterinary+Quarterly&atitle=Kidney+function+and+glucose+metabolism+in+overweight+and+obese+cats.&volume=40&issue=1&spage=132&epage=139&date=2020&doi=10.1080%2F01652176.2020.1759844&pmid=32315583&sid=OVID:medline
+
+<1366>
+Unique Identifier
+ 32315336
+Title
+ Weight-gain induced changes in renal perfusion assessed by contrast-enhanced ultrasound precede increases in urinary protein excretion suggestive of glomerular and tubular injury and normalize after weight-loss in dogs.
+Source
+ PLoS ONE [Electronic Resource]. 15(4):e0231662, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu DJX; Stock E; Broeckx BJG; Daminet S; Meyer E; Delanghe JR; Croubels S; Devreese M; Nguyen P; Bogaerts E; Hesta M; Vanderperren K
+Author NameID
+ Liu, Daisy J X; ORCID: https://orcid.org/0000-0002-2970-4357
+ Devreese, Mathias; ORCID: https://orcid.org/0000-0003-2512-4176
+Authors Full Name
+ Liu, Daisy J X; Stock, Emmelie; Broeckx, Bart J G; Daminet, Sylvie; Meyer, Evelyne; Delanghe, Joris R; Croubels, Siska; Devreese, Mathias; Nguyen, Patrick; Bogaerts, Evelien; Hesta, Myriam; Vanderperren, Katrien.
+Institution
+ Liu, Daisy J X. Department of Medical Imaging of Domestic Animals and Orthopedics of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Stock, Emmelie. Department of Medical Imaging of Domestic Animals and Orthopedics of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Broeckx, Bart J G. Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Daminet, Sylvie. Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Meyer, Evelyne. Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Delanghe, Joris R. Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Health Medicine and Life Sciences, Ghent University, Ghent, Belgium.
+ Croubels, Siska. Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Devreese, Mathias. Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Nguyen, Patrick. Oniris, National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.
+ Bogaerts, Evelien. Department of Medical Imaging of Domestic Animals and Orthopedics of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Hesta, Myriam. Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+ Vanderperren, Katrien. Department of Medical Imaging of Domestic Animals and Orthopedics of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
+MeSH Subject Headings
+ Animals
+ Biomarkers/ur [Urine]
+ Blood Urea Nitrogen
+ Contrast Media/pd [Pharmacology]
+ Creatinine/bl [Blood]
+ Disease Models, Animal
+ Dogs
+ Glomerular Filtration Rate
+ Glomerulonephritis/et [Etiology]
+ *Glomerulonephritis/me [Metabolism]
+ Glomerulonephritis/pa [Pathology]
+ Glomerulonephritis/ur [Urine]
+ Humans
+ Kidney Glomerulus/dg [Diagnostic Imaging]
+ Kidney Glomerulus/in [Injuries]
+ *Kidney Glomerulus/me [Metabolism]
+ Kidney Glomerulus/pa [Pathology]
+ Kidney Tubules/dg [Diagnostic Imaging]
+ Kidney Tubules/in [Injuries]
+ *Kidney Tubules/me [Metabolism]
+ Kidney Tubules/pa [Pathology]
+ Obesity/co [Complications]
+ Obesity/dg [Diagnostic Imaging]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Ultrasonography
+ Urinary Tract/me [Metabolism]
+ Urinary Tract/pa [Pathology]
+ *Weight Gain/ge [Genetics]
+ Weight Gain/ph [Physiology]
+ Weight Loss/ge [Genetics]
+ Weight Loss/ph [Physiology]
+Abstract
+ Early detection of obesity-related glomerulopathy in humans is challenging as it might not be detected by routine biomarkers of kidney function. This study's aim was to use novel kidney biomarkers and contrast-enhanced ultrasound (CEUS) to evaluate the effect of obesity development and weight-loss on kidney function, perfusion, and injury in dogs. Sixteen healthy lean adult beagles were assigned randomly but age-matched to a control group (CG) (n = 8) fed to maintain a lean body weight (BW) for 83 weeks; or to a weight-change group (WCG) (n = 8) fed the same diet to induce obesity (week 0-47), to maintain stable obese weight (week 47-56) and to lose BW (week 56-83). At 8 time points, values of systolic blood pressure (sBP); serum creatinine (sCr); blood urea nitrogen (BUN); serum cystatin C (sCysC); urine protein-to-creatinine ratio (UPC); and urinary biomarkers of glomerular and tubular injury were measured. Glomerular filtration rate (GFR) and renal perfusion using CEUS were assayed (except for week 68). For CEUS, intensity- and time-related parameters representing blood volume and velocity were derived from imaging data, respectively. At 12-22% weight-gain, cortical time-to-peak, representing blood velocity, was shorter in the WCG vs. the CG. After 37% weight-gain, sCysC, UPC, glomerular and tubular biomarkers of injury, urinary immunoglobulin G and urinary neutrophil gelatinase-associated lipocalin, respectively, were higher in the WCG. sBP, sCr, BUN and GFR were not significantly different. After 23% weight-loss, all alterations were attenuated. Early weight-gain in dogs induced renal perfusion changes measured with CEUS, without hyperfiltration, preceding increased urinary protein excretion with potential glomerular and tubular injury. The combined use of routine biomarkers of kidney function, CEUS and site-specific urinary biomarkers might be valuable in assessing kidney health of individuals at risk for obesity-related glomerulopathy in a non-invasive manner.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Contrast Media). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1371%2fjournal.pone.0231662
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Weight-gain+induced+changes+in+renal+perfusion+assessed+by+contrast-enhanced+ultrasound+precede+increases+in+urinary+protein+excretion+suggestive+of+glomerular+and+tubular+injury+and+normalize+after+weight-loss+in+dogs.&volume=15&issue=4&spage=e0231662&epage=&date=2020&doi=10.1371%2Fjournal.pone.0231662&pmid=32315336&sid=OVID:medline
+
+<1367>
+Unique Identifier
+ 32308111
+Title
+ Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring. [Review]
+Source
+ Journal of the American Heart Association. 9(8):e011541, 2020 04 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Helle E; Priest JR
+Authors Full Name
+ Helle, Emmi; Priest, James R.
+Institution
+ Helle, Emmi. Stem Cells and Metabolism Research Program Faculty of Medicine University of Helsinki Helsinki Finland.
+ Helle, Emmi. Pediatric Cardiology Children's Hospital, and Pediatric Research Center Helsinki University Hospital University of Helsinki Helsinki Finland.
+ Priest, James R. Department of Pediatrics (Cardiology) Stanford University School of Medicine Stanford CA.
+ Priest, James R. Chan-Zuckerberg Biohub San Francisco CA.
+MeSH Subject Headings
+ Adiposity
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Cardiometabolic Risk Factors
+ Diabetes, Gestational/bl [Blood]
+ *Diabetes, Gestational/ep [Epidemiology]
+ Diabetes, Gestational/th [Therapy]
+ Female
+ Fetal Development
+ Gestational Weight Gain
+ Heart Defects, Congenital/bl [Blood]
+ *Heart Defects, Congenital/ep [Epidemiology]
+ Heart Defects, Congenital/pc [Prevention & Control]
+ Humans
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ Pregnancy
+ Pregnancy in Diabetics/bl [Blood]
+ *Pregnancy in Diabetics/ep [Epidemiology]
+ Pregnancy in Diabetics/th [Therapy]
+ Protective Factors
+ Risk Assessment
+Keyword Heading
+ cardiometabolic
+ congenital heart disease
+ maternal diabetes mellitus
+ maternal obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Congenital heart disease (CHD) is the most common anatomical malformation occurring live-born infants and an increasing cause of morbidity and mortality across the lifespan and throughout the world. Population-based observations have long described associations between maternal cardiometabolic disorders and the risk of CHD in the offspring. Here we review the epidemiological evidence and clinical observations relating maternal obesity and diabetes mellitus to the risk of CHD offspring with particular attention to mechanistic models of maternal-fetal risk transmission and first trimester disturbances of fetal cardiac development. A deeper understanding of maternal risk factors holds the potential to improve both prenatal detection of CHD by identifying at-risk pregnancies, along with primary prevention of disease by improving preconception and prenatal treatment of at-risk mothers.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1161%2fJAHA.119.011541
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Helle&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Maternal+Obesity+and+Diabetes+Mellitus+as+Risk+Factors+for+Congenital+Heart+Disease+in+the+Offspring.&volume=9&issue=8&spage=e011541&epage=&date=2020&doi=10.1161%2FJAHA.119.011541&pmid=32308111&sid=OVID:medline
+
+<1368>
+Unique Identifier
+ 32307670
+Title
+ Effect of Weight Loss Surgery on Biomarkers of Angiogenesis in Obese Patients.
+Source
+ Obesity Surgery. 30(9):3417-3425, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wiewiora M; Mertas A; Gluck M; Nowowiejska-Wiewiora A; Czuba Z; Piecuch J
+Authors Full Name
+ Wiewiora, Maciej; Mertas, Anna; Gluck, Marek; Nowowiejska-Wiewiora, Alicja; Czuba, Zenon; Piecuch, Jerzy.
+Institution
+ Wiewiora, Maciej. Department of General and Bariatric Surgery and Emergency Medicine, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland. m-wiewiora@tlen.pl.
+ Wiewiora, Maciej. Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Zabrze, Poland. m-wiewiora@tlen.pl.
+ Mertas, Anna. Department of Microbiology and Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Gluck, Marek. Department of General and Bariatric Surgery and Emergency Medicine, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Nowowiejska-Wiewiora, Alicja. Third Department of Cardiology, Silesian Centre for Heart Disease, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Czuba, Zenon. Department of Microbiology and Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Piecuch, Jerzy. Department of General and Bariatric Surgery and Emergency Medicine, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+MeSH Subject Headings
+ *Bariatric Surgery
+ Biomarkers
+ Follow-Up Studies
+ Gastrectomy
+ Humans
+ *Laparoscopy
+ Obesity/su [Surgery]
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+ Retrospective Studies
+ Treatment Outcome
+ Vascular Endothelial Growth Factor A
+Keyword Heading
+ Angiogenesis
+ Bariatric surgery
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The present study aims to clarify the effects of weight loss on biomarkers associated with angiogenesis in patients who underwent laparoscopic sleeve gastrectomy (SG) or adjustable gastric banding (LAGB) in the 12-month follow-up study.
+
+ MATERIALS AND METHODS: We studied 24 obese patients who underwent laparoscopic weight loss surgery, 13 of whom underwent SG and 11 of whom underwent LAGB. We evaluated the circulating level of angiogenesis biomarkers preoperatively and 12 months after surgery.
+
+ RESULTS: Before surgery, the following angiogenic circulating factors were significantly higher than those of healthy subjects: angiopoietin 2 (ANG-2) (p < .05), granulocyte colony-stimulating factor (G-CSF) (p < .05), hepatocyte growth factor (HGF) (p < .01), platelet endothelial cell adhesion molecule (PECAM-1) (p < .01), and vascular endothelial growth factor (VEGF) (p < .05). The following angiogenesis biomarkers decreased significantly after weight loss compared with their baseline values: ANG-2 (p < .05), follistatin (p < .05), HGF (p < .01), PECAM-1 (p < .01), and VEGF (p < .05). There were no significant differences in the circulating levels of angiogenesis biomarkers between individuals who underwent SG and those who underwent LAGB; however, HGF, PECAM-1, and VEGF tended to be lower after SG. %BMI correlated negatively with HGF, PECAM-1, and VEGF. A similar significant negative correlation was found for %WL and %EWL. WHR correlated with PDGF-B and VEGF.
+
+ CONCLUSIONS: We concluded that weight loss surgery induces the changes of circulating levels of angiogenesis biomarkers in obese patients. The changes in angiogenesis status in obese patients who lost weight after bariatric surgery depended on the amount of weight loss.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Vascular Endothelial Growth Factor A).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs11695-020-04580-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wiewiora&issn=0960-8923&title=Obesity+Surgery&atitle=Effect+of+Weight+Loss+Surgery+on+Biomarkers+of+Angiogenesis+in+Obese+Patients.&volume=30&issue=9&spage=3417&epage=3425&date=2020&doi=10.1007%2Fs11695-020-04580-7&pmid=32307670&sid=OVID:medline
+
+<1369>
+Unique Identifier
+ 32302714
+Title
+ Molokhia leaf extract prevents gut inflammation and obesity.
+Source
+ Journal of Ethnopharmacology. 257:112866, 2020 Jul 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee HB; Oh MJ; Do MH; Kim YS; Park HY
+Authors Full Name
+ Lee, Hye-Bin; Oh, Mi-Jin; Do, Moon Ho; Kim, Young-Soo; Park, Ho-Young.
+Institution
+ Lee, Hye-Bin. Division of Functional Food Research, Korea Food Research Institute, Jeollabuk-do, 55365, Republic of Korea; Department of Food Science and Technology, Chonbuk National University, Jeollabuk-do, 54896, Republic of Korea. Electronic address: 50023@kfri.re.kr.
+ Oh, Mi-Jin. Division of Functional Food Research, Korea Food Research Institute, Jeollabuk-do, 55365, Republic of Korea. Electronic address: mjoh@kfri.re.kr.
+ Do, Moon Ho. Division of Functional Food Research, Korea Food Research Institute, Jeollabuk-do, 55365, Republic of Korea. Electronic address: Do.Moon-ho@kfri.re.kr.
+ Kim, Young-Soo. Department of Food Science and Technology, Chonbuk National University, Jeollabuk-do, 54896, Republic of Korea. Electronic address: ykim@jbnu.ac.kr.
+ Park, Ho-Young. Division of Functional Food Research, Korea Food Research Institute, Jeollabuk-do, 55365, Republic of Korea. Electronic address: hypark@kfri.re.kr.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ Adipocytes/de [Drug Effects]
+ Adipocytes/me [Metabolism]
+ Animals
+ Anti-Inflammatory Agents/ip [Isolation & Purification]
+ *Anti-Inflammatory Agents/pd [Pharmacology]
+ Anti-Obesity Agents/ip [Isolation & Purification]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ *Bacteria/de [Drug Effects]
+ Bacteria/en [Enzymology]
+ Bacteria/gd [Growth & Development]
+ Biomarkers/bl [Blood]
+ Colitis/me [Metabolism]
+ Colitis/mi [Microbiology]
+ *Colitis/pc [Prevention & Control]
+ *Colon/mi [Microbiology]
+ Corchorus/ch [Chemistry]
+ *Corchorus
+ Diet, High-Fat
+ Disease Models, Animal
+ Dysbiosis
+ Gastrointestinal Agents/ip [Isolation & Purification]
+ *Gastrointestinal Agents/pd [Pharmacology]
+ *Gastrointestinal Microbiome/de [Drug Effects]
+ Lipid Metabolism/de [Drug Effects]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/me [Metabolism]
+ Obesity/mi [Microbiology]
+ *Obesity/pc [Prevention & Control]
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ Plant Leaves/ch [Chemistry]
+ *Plant Leaves
+Keyword Heading
+ Corchorus olitorius L.
+ Inflammation
+ Microbiota
+ Molokhia
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ ETHNOPHARMACOLOGICAL RELEVANCE: Molokhia is highly consumed in Egypt as edible and medicinal plants, and its leaves are used for the treatment of pain, fever, and inflammation.
+
+ AIM OF THE STUDY: High-fat diet (HFD) induces gut dysbiosis, which is closely linked to metabolic diseases including obesity and leaky gut. The effects of molokhia (Corchorus olitorius L.) on anti-obesity and gut health were investigated in this study.
+
+ MATERIALS AND METHODS: The effects of a water-soluble extract from molokhia leaves (WM) on lipid accumulation in 3T3-L1 adipocytes and on body weight, gut permeability, hormone levels, fecal enzyme activity of the intestinal microflora, and gut microbiota in HFD-induced C57BL/6J mice were examined.
+
+ RESULTS: WM treatment significantly inhibited lipid accumulation in 3T3-L1 adipocytes. Mice treated with 100 mg/kg WM had 13.1, 52.4, and 17.4% significantly lower body weights, gut permeability, and hepatic lipid accumulation than those in the HFD group, respectively. In addition, WM influenced gut health by inhibiting metabolic endotoxemia and colonic inflammation. It also altered the composition of the gut microbiota; in particular, it increased the abundance of Lactobacillus and decreased that of Desulfovibrio.
+
+ CONCLUSION: Our results extend our understanding of the beneficial effects of WM consumption, including the prevention of gut dysbiosis and obesity. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Inflammatory Agents). 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Gastrointestinal Agents). 0 (Plant Extracts).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.jep.2020.112866
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=0378-8741&title=Journal+of+Ethnopharmacology&atitle=Molokhia+leaf+extract+prevents+gut+inflammation+and+obesity.&volume=257&issue=&spage=112866&epage=&date=2020&doi=10.1016%2Fj.jep.2020.112866&pmid=32302714&sid=OVID:medline
+
+<1370>
+Unique Identifier
+ 32299059
+Title
+ Angiogenic factor abnormalities and risk of peripartum complications and prematurity among urban predominantly obese parturients with chronic hypertension.
+Source
+ Pregnancy Hypertension. 20:124-130, 2020 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Heimberger S; Mueller A; Ratnaparkhi R; Perdigao JL; Rana S
+Authors Full Name
+ Heimberger, Sarah; Mueller, Ariel; Ratnaparkhi, Rubina; Perdigao, Joana Lopes; Rana, Sarosh.
+Institution
+ Heimberger, Sarah. University of Chicago Pritzker School of Medicine, Chicago, IL, United States.
+ Mueller, Ariel. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Chicago, IL, United States; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
+ Ratnaparkhi, Rubina. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Chicago, IL, United States.
+ Perdigao, Joana Lopes. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Pennsylvania, PA, United States.
+ Rana, Sarosh. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Chicago, IL, United States. Electronic address: srana@bsd.uchicago.edu.
+MeSH Subject Headings
+ Adult
+ Black or African American
+ Biomarkers/bl [Blood]
+ Birth Weight
+ Blood Pressure
+ Chicago/ep [Epidemiology]
+ Chronic Disease
+ Female
+ Gestational Age
+ Humans
+ *Hypertension, Pregnancy-Induced/bl [Blood]
+ Hypertension, Pregnancy-Induced/di [Diagnosis]
+ Hypertension, Pregnancy-Induced/eh [Ethnology]
+ Hypertension, Pregnancy-Induced/pp [Physiopathology]
+ Infant, Low Birth Weight
+ Infant, Premature
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/eh [Ethnology]
+ Obesity/pp [Physiopathology]
+ Peripartum Period/bl [Blood]
+ *Placenta Growth Factor/bl [Blood]
+ Pregnancy
+ *Premature Birth/bl [Blood]
+ Premature Birth/di [Diagnosis]
+ Premature Birth/eh [Ethnology]
+ Prevalence
+ Retrospective Studies
+ Risk Factors
+ Urban Health
+ *Vascular Endothelial Growth Factor Receptor-1/bl [Blood]
+Keyword Heading
+ Angiogenic biomarkers
+ Chronic hypertension pregnancy
+ Preeclampsia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To compare characteristics and outcomes of women with chronic hypertension (cHTN) between those with normal and abnormal plasma angiogenic profiles.
+
+ STUDY DESIGN: This secondary analysis explored associations between angiogenic markers soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) drawn prior to delivery among women with history of cHTN who were enrolled between 22 and 41weeks. Patients were divided into two groups based on sFlt1/PlGF ratio, namely low sFlt1/PlGF (<85) and high sFlt1/PlGF (>=85) ratio.
+
+ RESULTS: Of the 115 patients, 76% were African American. Compared to women with low sFlt1/PlGF (n=78), patients with high sFlt1/PlGF (n=37) had higher median antenatal blood pressures (systolic mmHg 179 vs 155; diastolic 106 vs 91), lower gestational age at delivery (34.7 vs 38.2weeks), lower birthweight (1940 vs 3103g), and a higher prevalence of preterm delivery<34 (40.5% vs 7.7%) and<37weeks (64.9% vs 20.5%), all p<0.001. Importantly, more women with high sFlt1/PlGF had a diagnosis of superimposed preeclampsia (62.2% vs 26.9%, p=0.003), preeclampsia with severe features (59.5% vs 20.5%, p<0.0001), maternal adverse outcomes (24.3% vs 3.9%, p=0.002), neonatal intensive care unit admissions (71.9% vs 40.8%; p=0.003), severe postpartum hypertension (67.6% vs 38.5%, p=0.01) and longer hospital stays (median 6.0 vs 4.5days, p=0.003).
+
+ DISCUSSION: In contrast to patients with a low ratio, high sFlt1/PlGF is characterized by an increased risk of maternal adverse outcomes and prematurity. Incorporation of angiogenic biomarkers while managing cHTN may improve accuracy of early identification of adverse outcomes to improve outcomes. Copyright © 2020 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (PGF protein, human). 144589-93-5 (Placenta Growth Factor). EC 2-7-10-1 (FLT1 protein, human). EC 2-7-10-1 (Vascular Endothelial Growth Factor Receptor-1).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.preghy.2020.04.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Heimberger&issn=2210-7789&title=Pregnancy+Hypertension&atitle=Angiogenic+factor+abnormalities+and+risk+of+peripartum+complications+and+prematurity+among+urban+predominantly+obese+parturients+with+chronic+hypertension.&volume=20&issue=&spage=124&epage=130&date=2020&doi=10.1016%2Fj.preghy.2020.04.004&pmid=32299059&sid=OVID:medline
+
+<1371>
+Unique Identifier
+ 32296838
+Title
+ Characterization of Gut Microbiota Composition in Hemodialysis Patients With Normal Weight Obesity.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(6), 2020 06 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lin TY; Wu PH; Lin YT; Hung SC
+Authors Full Name
+ Lin, Ting-Yun; Wu, Ping-Hsun; Lin, Yi-Ting; Hung, Szu-Chun.
+Institution
+ Lin, Ting-Yun. Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and School of Medicine, Tzu Chi University, Hualien, Taiwan.
+ Wu, Ping-Hsun. Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
+ Lin, Yi-Ting. Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
+ Hung, Szu-Chun. Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and School of Medicine, Tzu Chi University, Hualien, Taiwan.
+MeSH Subject Headings
+ Aged
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ *Gastrointestinal Microbiome
+ Humans
+ Male
+ *Metagenome
+ Obesity/ge [Genetics]
+ *Obesity/mi [Microbiology]
+ Overweight/ge [Genetics]
+ *Overweight/mi [Microbiology]
+ Prognosis
+ RNA, Ribosomal, 16S/an [Analysis]
+ RNA, Ribosomal, 16S/ge [Genetics]
+ *Renal Dialysis/mt [Methods]
+Keyword Heading
+ Faecalibacterium
+ body composition
+ dysbiosis
+ gut microbiota
+ hemodialysis
+ normal weight obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Normal weight obesity (NWO), defined by a normal body mass index (BMI) but increased body fat percentage (BF%), is associated with an increased risk of cardiovascular disease and mortality. NWO is characterized by inflammation and muscle wasting in chronic kidney disease (CKD), but the underlying mechanisms remain largely unknown. Gut microbiota has been implicated in the regulation of host metabolism and may play important roles in the development of NWO in CKD.
+
+ METHODS: In this case-control study, we examined the gut microbial diversity and taxonomy in 96 hemodialysis patients with normal weight (BMI < 25 kg/m2 and BF% <= 25% for men or <= 35% for women; n = 32), NWO (BMI < 25 kg/m2 and BF% > 25% for men or > 35% for women; n = 32), and overweight/obesity (BMI >= 25 kg/m2; n = 32), matched for age, gender, and diabetes. BF% was measured using bioimpedance spectroscopy device. Gut microbiota was determined by 16S rRNA sequencing.
+
+ RESULTS: We found that alpha-diversity was significantly different among the 3 adiposity phenotypes, with NWO being the least diverse. alpha-diversity was positively correlated with BMI, subjective global assessment score, and physical activity, but negatively correlated with interleukin-6 and tumor necrosis factor-alpha. Patients with or without NWO were distinguished with respect to principal coordinate analysis of beta-diversity. Notably, the relative abundance of butyrate-producing bacteria, such as Faecalibacterium prausnitzii and Coprococcus, was markedly reduced in patients with NWO.
+
+ CONCLUSION: Our findings support associations between gut dysbiosis and a proinflammatory and catabolic state in hemodialysis patients with NWO. Copyright © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Ribosomal, 16S).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1210%2fclinem%2fdgaa166
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lin&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Characterization+of+Gut+Microbiota+Composition+in+Hemodialysis+Patients+With+Normal+Weight+Obesity.&volume=105&issue=6&spage=2006&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgaa166&pmid=32296838&sid=OVID:medline
+
+<1372>
+Unique Identifier
+ 32296105
+Title
+ Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice.
+Source
+ Scientific Reports. 10(1):6479, 2020 04 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sanada S; Suzuki T; Nagata A; Hashidume T; Yoshikawa Y; Miyoshi N
+Authors Full Name
+ Sanada, Shunsuke; Suzuki, Takuji; Nagata, Akika; Hashidume, Tsutomu; Yoshikawa, Yuko; Miyoshi, Noriyuki.
+Institution
+ Sanada, Shunsuke. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
+ Suzuki, Takuji. Food Environmental Design Course, Faculty of Education, Art and Science, Yamagata University, Yamagata, Japan.
+ Nagata, Akika. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
+ Hashidume, Tsutomu. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
+ Yoshikawa, Yuko. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
+ Yoshikawa, Yuko. School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan.
+ Miyoshi, Noriyuki. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan. miyoshin@u-shizuoka-ken.ac.jp.
+MeSH Subject Headings
+ Animals
+ *Bile Pigments/bl [Blood]
+ Bile Pigments/im [Immunology]
+ Bile Pigments/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Disease Models, Animal
+ *Gastrointestinal Microbiome/im [Immunology]
+ *Host Microbial Interactions/im [Immunology]
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/di [Diagnosis]
+ *Inflammation/im [Immunology]
+ Inflammation/mi [Microbiology]
+ Intestinal Mucosa/im [Immunology]
+ Intestinal Mucosa/me [Metabolism]
+ Intestinal Mucosa/mi [Microbiology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ *Obesity/im [Immunology]
+ Obesity/mi [Microbiology]
+ RAW 264.7 Cells
+Abstract
+ It is crucial that the host and intestinal microflora interact and influence each other to maintain homeostasis and trigger pathological processes. Recent studies have shown that transplantation of the murine intestinal content to recipient germ-free mice enables transmission of the donor's phenotypes, such as low level chronic inflammation associated with lifestyle-related diseases. These findings indicate that intestinal bacteria produce some molecules to trigger pathological signals. However, fecal microbial metabolites that induce obesity and the type II diabetic phenotype have not been fully clarified. Here, we showed that the intestinal bacterial metabolite stercobilin, a pigment of feces, induced proinflammatory activities including TNF-alpha and IL-1beta induction in mouse macrophage RAW264 cells. Proinflammatory stercobilin levels were significantly higher in ob/ob mice feces than in the feces of control C57BL/6 J mice. Moreover, in this study, we detected stercobilin in mice plasma for the first time, and the levels were higher in ob/ob mice than that of C57BL/6 J mice. Therefore, stercobilin is potentially reabsorbed, circulated through the blood system, and contributes to low level chronic inflammation in ob/ob mice. Since, stercobilin is a bioactive metabolite, it could be a potentially promising biomarker for diagnosis. Further analyses to elucidate the metabolic rate and the reabsorption mechanism of stercobilin may provide possible therapeutic and preventive targets.
+Registry Number/Name of Substance
+ 0 (Bile Pigments). 0 (Biomarkers). 17G380DO11 (stercobilin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1038%2fs41598-020-63627-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sanada&issn=2045-2322&title=Scientific+Reports&atitle=Intestinal+microbial+metabolite+stercobilin+involvement+in+the+chronic+inflammation+of+ob%2Fob+mice.&volume=10&issue=1&spage=6479&epage=&date=2020&doi=10.1038%2Fs41598-020-63627-y&pmid=32296105&sid=OVID:medline
+
+<1373>
+Unique Identifier
+ 32290296
+Title
+ The Role of Selenium in Health and Disease: Emerging and Recurring Trends.
+Source
+ Nutrients. 12(4), 2020 Apr 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Meplan C; Hughes DJ
+Author NameID
+ Hughes, David J; ORCID: https://orcid.org/0000-0003-1668-8770
+Authors Full Name
+ Meplan, Catherine; Hughes, David J.
+Institution
+ Meplan, Catherine. School of Biomedical, Nutritional and Sport Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
+ Hughes, David J. Cancer Biology and Therapeutics Group, UCD Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ Humans
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Neoplasms/di [Diagnosis]
+ *Neoplasms/et [Etiology]
+ Neoplasms/me [Metabolism]
+ Nutritional Physiological Phenomena
+ Obesity/di [Diagnosis]
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Selenium/df [Deficiency]
+ Selenium/me [Metabolism]
+ *Selenium/ph [Physiology]
+ Selenium-Binding Proteins/me [Metabolism]
+ Selenoprotein P/me [Metabolism]
+ Selenoproteins/me [Metabolism]
+Abstract
+ In this Special Issue of Nutrients, "The Role of Selenium in Health and Disease" covers diverse diseases in the 8 original research articles and 2 reviews, such as cardiovascular disorders (CVD), metabolic syndrome, obesity, cancer, and viral infection, and highlights novel potential biomarkers of disease risk and prognosis [...].
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (SELENBP1 protein, human). 0 (SELENOP protein, human). 0 (Selenium-Binding Proteins). 0 (Selenoprotein P). 0 (Selenoproteins). H6241UJ22B (Selenium).
+Publication Type
+ Editorial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12041049
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Meplan&issn=2072-6643&title=Nutrients&atitle=The+Role+of+Selenium+in+Health+and+Disease%3A+Emerging+and+Recurring+Trends.&volume=12&issue=4&spage=&epage=&date=2020&doi=10.3390%2Fnu12041049&pmid=32290296&sid=OVID:medline
+
+<1374>
+Unique Identifier
+ 32290082
+Title
+ Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities. [Review]
+Source
+ International Journal of Molecular Sciences. 21(7), 2020 Apr 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Opazo-Rios L; Mas S; Marin-Royo G; Mezzano S; Gomez-Guerrero C; Moreno JA; Egido J
+Author NameID
+ Opazo-Rios, Lucas; ORCID: https://orcid.org/0000-0003-3586-3319
+ Mas, Sebastian; ORCID: https://orcid.org/0000-0001-6604-3327
+ Gomez-Guerrero, Carmen; ORCID: https://orcid.org/0000-0001-9001-5414
+ Moreno, Juan Antonio; ORCID: https://orcid.org/0000-0002-7468-2871
+Authors Full Name
+ Opazo-Rios, Lucas; Mas, Sebastian; Marin-Royo, Gema; Mezzano, Sergio; Gomez-Guerrero, Carmen; Moreno, Juan Antonio; Egido, Jesus.
+Institution
+ Opazo-Rios, Lucas. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Mas, Sebastian. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Marin-Royo, Gema. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Mezzano, Sergio. Laboratorio de Nefrologia, Facultad de Medicina, Universidad Austral de Chile, 5090000 Valdivia, Chile.
+ Gomez-Guerrero, Carmen. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+ Moreno, Juan Antonio. Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain.
+ Moreno, Juan Antonio. Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain.
+ Moreno, Juan Antonio. Hospital Universitario Reina Sofia, 14004 Cordoba, Spain.
+ Egido, Jesus. Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Clinical Decision-Making
+ Diabetic Nephropathies/di [Diagnosis]
+ *Diabetic Nephropathies/et [Etiology]
+ *Diabetic Nephropathies/me [Metabolism]
+ Diabetic Nephropathies/th [Therapy]
+ Disease Management
+ *Disease Susceptibility
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/co [Complications]
+ Fatty Acids, Nonesterified/bl [Blood]
+ Fatty Acids, Nonesterified/me [Metabolism]
+ Glycogen/me [Metabolism]
+ Humans
+ Kidney/me [Metabolism]
+ Kidney/pa [Pathology]
+ *Lipid Metabolism
+ Mitochondria/me [Metabolism]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Prognosis
+ Signal Transduction
+Keyword Heading
+ chronic kidney disease
+ diabetic nephropathy
+ fatty kidney
+ lipotoxicity
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas, skeletal muscle, liver, and kidney. Serum lipid abnormalities and renal ectopic lipid accumulation have been associated with the development of kidney diseases, in particular diabetic nephropathy. Chronic hyperinsulinemia, often seen in type 2 diabetes, plays a crucial role in blood and liver lipid metabolism abnormalities, thus resulting in increased non-esterified fatty acids (NEFA). Excessive lipid accumulation alters cellular homeostasis and activates lipogenic and glycogenic cell-signaling pathways. Recent evidences indicate that both quantity and quality of lipids are involved in renal damage associated to lipotoxicity by activating inflammation, oxidative stress, mitochondrial dysfunction, and cell-death. The pathological effects of lipotoxicity have been observed in renal cells, thus promoting podocyte injury, tubular damage, mesangial proliferation, endothelial activation, and formation of macrophage-derived foam cells. Therefore, this review examines the recent preclinical and clinical research about the potentially harmful effects of lipids in the kidney, metabolic markers associated with these mechanisms, major signaling pathways affected, the causes of excessive lipid accumulation, and the types of lipids involved, as well as offers a comprehensive update of therapeutic strategies targeting lipotoxicity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Nonesterified). 9005-79-2 (Glycogen).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijms21072632
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Opazo-Rios&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Lipotoxicity+and+Diabetic+Nephropathy%3A+Novel+Mechanistic+Insights+and+Therapeutic+Opportunities.&volume=21&issue=7&spage=2632&epage=&date=2020&doi=10.3390%2Fijms21072632&pmid=32290082&sid=OVID:medline
+
+<1375>
+Unique Identifier
+ 32289859
+Title
+ Effects of Obesity Surgery on Blood Coagulation and Fibrinolysis: A Literature Review. [Review]
+Source
+ Thrombosis & Haemostasis. 120(4):579-591, 2020 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bladbjerg EM; Stolberg CR; Juhl CB
+Authors Full Name
+ Bladbjerg, Else Marie; Stolberg, Charlotte Ron; Juhl, Claus Bogh.
+Institution
+ Bladbjerg, Else Marie. Department of Clinical Biochemistry, Unit for Thrombosis Research, University Hospital of Southern Denmark, Esbjerg, Denmark.
+ Bladbjerg, Else Marie. Institute of Regional Health Research, University of Southern Denmark, Denmark.
+ Stolberg, Charlotte Ron. Institute of Regional Health Research, University of Southern Denmark, Denmark.
+ Stolberg, Charlotte Ron. Department of Medicine, Section of Endocrinology, University Hospital of Southern Denmark, Esbjerg, Denmark.
+ Juhl, Claus Bogh. Institute of Regional Health Research, University of Southern Denmark, Denmark.
+ Juhl, Claus Bogh. Department of Medicine, Section of Endocrinology, University Hospital of Southern Denmark, Esbjerg, Denmark.
+MeSH Subject Headings
+ Animals
+ *Bariatric Surgery
+ Biomarkers/me [Metabolism]
+ Blood Coagulation
+ Fibrinolysis
+ Hemostasis
+ Humans
+ Obesity/co [Complications]
+ *Obesity/su [Surgery]
+ Thrombosis/et [Etiology]
+ *Thrombosis/pc [Prevention & Control]
+ Treatment Outcome
+Abstract
+ OBJECTIVE: Obesity is characterized by a disturbed hemostatic balance with increased coagulation and impaired fibrinolysis. This increases the risk of thrombosis, and the risk is lowered after obesity surgery. Over the past 25 years, several studies have contributed to understand the mechanisms behind the antithrombotic effect of obesity surgery, and this literature review summarizes the results of these studies.
+
+ METHODS: A detailed literature search on the effects of obesity surgery on the hemostatic balance was conducted.
+
+ RESULTS: The 25 relevant studies reviewed demonstrated that obesity surgery has favorable effects on many biomarkers of coagulation and fibrinolysis. The evidence is substantial for fibrinogen and plasminogen activator inhibitor type 1 with average reductions from 1 to 24 months after obesity surgery of 17 and 48%, respectively. For most other biomarkers, the evidence is moderate or weak with average effect sizes varying from 2% for fiber mass length ratio to 70% for prothrombin fragment 1 + 2 and with a large variation between studies. Many studies are small and of short duration, and the surgical techniques differ. Also, studies are confounded by changes in medication, comorbidity, diet, and exercise. It is unknown whether the hemostatic changes are mediated by weight loss alone or by the accompanying metabolic improvements.
+
+ CONCLUSION: Despite issues of confounding, this review suggests that obesity surgery shifts the hemostatic balance in the antithrombotic direction, thereby reducing the thrombotic potential of people with obesity, but more studies are needed for most of the biomarkers. Copyright Georg Thieme Verlag KG Stuttgart . New York.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1055%2fs-0040-1702224
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bladbjerg&issn=0340-6245&title=Thrombosis+%26+Haemostasis&atitle=Effects+of+Obesity+Surgery+on+Blood+Coagulation+and+Fibrinolysis%3A+A+Literature+Review.&volume=120&issue=4&spage=579&epage=591&date=2020&doi=10.1055%2Fs-0040-1702224&pmid=32289859&sid=OVID:medline
+
+<1376>
+Unique Identifier
+ 32286392
+Title
+ Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents.
+Source
+ Scientific Reports. 10(1):6330, 2020 04 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hammad MM; Abu-Farha M; Al-Taiar A; Alam-Eldin N; Al-Sabah R; Shaban L; Al-Mulla F; Abubaker J; Rahman A
+Author NameID
+ Hammad, Maha M; ORCID: http://orcid.org/0000-0002-8974-8255
+ Abu-Farha, Mohamed; ORCID: http://orcid.org/0000-0001-8357-1252
+ Al-Taiar, Abdullah; ORCID: http://orcid.org/0000-0001-7421-3381
+ Alam-Eldin, Nada; ORCID: http://orcid.org/0000-0002-4766-8839
+ Al-Mulla, Fahd; ORCID: http://orcid.org/0000-0001-5409-3829
+ Rahman, Abdur; ORCID: http://orcid.org/0000-0002-5115-3053
+Authors Full Name
+ Hammad, Maha M; Abu-Farha, Mohamed; Al-Taiar, Abdullah; Alam-Eldin, Nada; Al-Sabah, Reem; Shaban, Lemia; Al-Mulla, Fahd; Abubaker, Jehad; Rahman, Abdur.
+Institution
+ Hammad, Maha M. Biochemistry and Molecular Biology Department, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Abu-Farha, Mohamed. Biochemistry and Molecular Biology Department, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al-Taiar, Abdullah. School of Community & Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, VA, USA.
+ Alam-Eldin, Nada. Biochemistry and Molecular Biology Department, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al-Sabah, Reem. Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
+ Shaban, Lemia. Department of Food Science and Nutrition, College of Life Sciences, Kuwait University, Kuwait City, Kuwait.
+ Al-Mulla, Fahd. Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Abubaker, Jehad. Biochemistry and Molecular Biology Department, Dasman Diabetes Institute, Kuwait City, Kuwait. jehad.abubakr@dasmaninstitute.org.
+ Rahman, Abdur. Department of Food Science and Nutrition, College of Life Sciences, Kuwait University, Kuwait City, Kuwait. abdurrahman.ahmad@ku.edu.kw.
+MeSH Subject Headings
+ Adolescent
+ *Angiopoietin-like Proteins/bl [Blood]
+ Angiopoietin-like Proteins/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ C-Reactive Protein/an [Analysis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Child
+ Cross-Sectional Studies
+ Female
+ Humans
+ Kuwait/ep [Epidemiology]
+ Lipoproteins, LDL/bl [Blood]
+ Lipoproteins, LDL/me [Metabolism]
+ Male
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Overweight/bl [Blood]
+ Overweight/co [Complications]
+ *Overweight/ep [Epidemiology]
+ Overweight/me [Metabolism]
+ Prevalence
+ Risk Factors
+Abstract
+ Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not well-studied. In this study, we tested the hypothesis of a positive association between plasma ANGPTL5, and obesity, high sensitivity C-reactive protein (HsCRP) and oxidized low-density lipoprotein (Ox-LDL) in adolescents. Adolescents (N = 431; age 11-14 years) were randomly selected from middle schools in Kuwait. Obesity was classified by the BMI-for-age based on the WHO growth charts. Plasma ANGPTL5, HsCRP, and Ox-LDL were measured using ELISA. The prevalence of overweight and obesity was 20.65% and 33.18%, respectively. Mean (SD) plasma ANGPTL5 levels were significantly higher in obese, compared with overweight and normal-weight adolescents (23.05 (8.79) vs 18.39 (7.08) ng/mL, and 18.26 (6.95) ng/ml, respectively). ANGPTL5 was positively associated with both HsCRP (rho=0.27, p < 0.001) and Ox-LDL (rho = 0.24, p < 0.001). In Conclusion, ANGPTL5 levels are elevated in obese adolescents and are associated with cardiovascular disease risk factors, HsCRP and Ox-LDL. The use of ANGPTL5 as a powerful diagnostic and prognostic tool in obesity and metabolic diseases needs to be further evaluated.
+Registry Number/Name of Substance
+ 0 (ANGPTL5 protein, human). 0 (Angiopoietin-like Proteins). 0 (Biomarkers). 0 (Lipoproteins, LDL). 0 (oxidized low density lipoprotein). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1038%2fs41598-020-63076-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hammad&issn=2045-2322&title=Scientific+Reports&atitle=Correlation+of+circulating+ANGPTL5+levels+with+obesity%2C+high+sensitivity+C-reactive+protein+and+oxidized+low-density+lipoprotein+in+adolescents.&volume=10&issue=1&spage=6330&epage=&date=2020&doi=10.1038%2Fs41598-020-63076-7&pmid=32286392&sid=OVID:medline
+
+<1377>
+Unique Identifier
+ 32278608
+Title
+ Carbohydrate quality, glycemic index, glycemic load and cardiometabolic risks in the US, Europe and Asia: A dose-response meta-analysis.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(6):853-871, 2020 06 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hardy DS; Garvin JT; Xu H
+Authors Full Name
+ Hardy, Dale S; Garvin, Jane T; Xu, Hongyan.
+Institution
+ Hardy, Dale S. Department of Medicine, Morehouse School of Medicine, Atlanta GA 30331, USA. Electronic address: dhardy@msm.edu.
+ Garvin, Jane T. School of Nursing, University of Saint Augustine for Health Sciences, Saint Augustine, FL 32086, USA.
+ Xu, Hongyan. Department of Population Health Sciences, Augusta University, Augusta GA 30912, USA.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Asia/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Coronary Disease/di [Diagnosis]
+ *Coronary Disease/ep [Epidemiology]
+ Coronary Disease/mo [Mortality]
+ Coronary Disease/pc [Prevention & Control]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/mo [Mortality]
+ Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ *Dietary Carbohydrates/ad [Administration & Dosage]
+ Dietary Carbohydrates/ae [Adverse Effects]
+ Dietary Carbohydrates/bl [Blood]
+ Europe/ep [Epidemiology]
+ Female
+ *Glycemic Index
+ *Glycemic Load
+ Humans
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Observational Studies as Topic
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ Stroke/di [Diagnosis]
+ *Stroke/ep [Epidemiology]
+ Stroke/mo [Mortality]
+ Stroke/pc [Prevention & Control]
+ United States/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ Cardiometabolic risks
+ Cereal fiber
+ Dose-response
+ Geographic regions
+ Glycemic index and glycemic load
+ Total dietary fiber
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Despite the proven evidence of high glycemic index (GI) and glycemic load (GL) diets to increase cardiometabolic risks, knowledge about the meta-evidence for carbohydrate quality within world geographic regions is limited. We conducted a meta-analysis to synthesize the evidence of GI/GL studies and carbohydrate quality, gathering additional exposures for carbohydrate, high glycemic carbohydrate, total dietary fiber, and cereal fiber and risks for type 2 diabetes (T2DM), coronary heart disease (CHD), stroke, and mortality, grouped into the US, Europe, and Asia. Secondary aims examined cardiometabolic risks in overweight/obese individuals, by sex, and dose-response dietary variable trends.
+
+ METHODS AND RESULTS: 40-prospective observational studies from 4-Medline bibliographical databases (Ovid, PubMed, EBSCOhost, CINAHL) were search up to November 2019. Random-effects hazard ratios (HR) and 95% confidence intervals (CI) for highest vs. lowest categories and continuous form combined were reported. Heterogeneity (I2>50%) was frequent in US GI/GL studies due to differing study characteristics. Increased risks ((HRGI,T2DM,US=1.14;CI:1.06,1.21), HRGL,T2DM,US=1.02 (1.01, 1.03)), HRGI,T2DM,Asia=1.25;1.02,1.53), and HRGL,T2DM,Asia=1.37 (1.17, 1.60)) were associated with cardiometabolic diseases. GI/GL in overweight/obese females had the strongest magnitude of risks in US-and Asian studies. Total dietary fiber (HRT2DM,US = 0.92;0.88,0.96) and cereal fiber (HRT2DM,US = 0.83;0.77,0.90) decreased risk of developing T2DM. Among females, we found protective dose-response risks for total dietary fiber (HR5g-total-dietary-fiber,T2DM,US = 0.94;0.92,0.97), but cereal fiber showed better ability to lower T2DM risk (HR5g-cereal-fiber,T2DM,US = 0.67;0.60,0.74). Total dietary-and cereal fibers' dose-response effects were nullified by GL, but not so for cereal fiber with GI.
+
+ CONCLUSIONS: Overweight/obese females could shift their carbohydrate intake for higher cereal fiber to decrease T2DM risk, but higher GL may cancel-out this effect. Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Carbohydrates).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, N.I.H., Extramural. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.numecd.2019.12.050
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hardy&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Carbohydrate+quality%2C+glycemic+index%2C+glycemic+load+and+cardiometabolic+risks+in+the+US%2C+Europe+and+Asia%3A+A+dose-response+meta-analysis.&volume=30&issue=6&spage=853&epage=871&date=2020&doi=10.1016%2Fj.numecd.2019.12.050&pmid=32278608&sid=OVID:medline
+
+<1378>
+Unique Identifier
+ 32277104
+Title
+ Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes.
+Source
+ Scientific Reports. 10(1):6170, 2020 04 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Qaddoumi MG; Alanbaei M; Hammad MM; Al Khairi I; Cherian P; Channanath A; Thanaraj TA; Al-Mulla F; Abu-Farha M; Abubaker J
+Authors Full Name
+ Qaddoumi, Mohammad G; Alanbaei, Muath; Hammad, Maha M; Al Khairi, Irina; Cherian, Preethi; Channanath, Arshad; Thanaraj, Thangavel Alphonse; Al-Mulla, Fahd; Abu-Farha, Mohamed; Abubaker, Jehad.
+Institution
+ Qaddoumi, Mohammad G. Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Qaddoumi, Mohammad G. Pharmacology and Therapeutics Department, Faculty of Pharmacy, Kuwait University, Kuwait City, Kuwait.
+ Alanbaei, Muath. Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
+ Hammad, Maha M. Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Al Khairi, Irina. Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Cherian, Preethi. Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
+ Channanath, Arshad. Functional Genomic Unit, Dasman Diabetes Institute, 15462, Kuwait City, Kuwait.
+ Thanaraj, Thangavel Alphonse. Functional Genomic Unit, Dasman Diabetes Institute, 15462, Kuwait City, Kuwait.
+ Al-Mulla, Fahd. Functional Genomic Unit, Dasman Diabetes Institute, 15462, Kuwait City, Kuwait.
+ Abu-Farha, Mohamed. Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait. mohamed.abufarha@dasmaninstitute.org.
+ Abubaker, Jehad. Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait. jehad.abubakr@dasmaninstitute.org.
+MeSH Subject Headings
+ Adult
+ Angiopoietin-Like Protein 6
+ *Angiopoietin-like Proteins/bl [Blood]
+ Angiopoietin-like Proteins/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ *Peroxidase/bl [Blood]
+ Peroxidase/me [Metabolism]
+Abstract
+ Myeloperoxidase (MPO) is positively associated with obesity and diet-induced insulin resistance. Angiopoietin-like protein 6 (ANGPTL6) regulates metabolic processes and counteract obesity through increased energy expenditure. This study aims to evaluate the plasma MPO and ANGPTL6 levels in obese and diabetic individuals as well as MPO association with biochemical markers of obesity. A total of 238 participants were enrolled, including 137 control and 101 type 2 diabetes (T2D) patients. ANGPTL6 and MPO levels and other biomarkers were measured via ELISA. ANGPTL6 levels were significantly higher in the diabetic population and obese individuals. When the group was stratified based on T2D, ANGPTL6 levels were significantly higher in obese-diabetic participants compared with non-obese-diabetics, but obese-non-diabetic individuals had similar ANGPTL6 levels to their controls. MPO levels were higher in obese compared with non-obese participants but did not differ between T2D and control participants. MPO levels were upregulated in obese compared with non-obese in both diabetics and non-diabetics. MPO was positively associated with ANGPTL6, triglyceride, BMI, TNF-alpha, high-sensitivity C-reactive protein, interleukin-6, and plasminogen activator inhibitor-1. Taken together, our findings suggest that both MPO and ANGPTL6 may regulate obesity, although MPO exerts this effect independent of diabetes while ANGPTL6 may have a modulatory role in diabetes.
+Registry Number/Name of Substance
+ 0 (ANGPTL6 protein, human). 0 (Angiopoietin-Like Protein 6). 0 (Angiopoietin-like Proteins). 0 (Biomarkers). EC 1-11-1-7 (MPO protein, human). EC 1-11-1-7 (Peroxidase).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1038%2fs41598-020-63149-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Qaddoumi&issn=2045-2322&title=Scientific+Reports&atitle=Investigating+the+Role+of+Myeloperoxidase+and+Angiopoietin-like+Protein+6+in+Obesity+and+Diabetes.&volume=10&issue=1&spage=6170&epage=&date=2020&doi=10.1038%2Fs41598-020-63149-7&pmid=32277104&sid=OVID:medline
+
+<1379>
+Unique Identifier
+ 32277008
+Title
+ Effects of Weight Loss and Weight Regain on Circulating Biomarkers in Overweight/Obese Breast Cancer Survivors Enrolled in a Weight Loss Trial in the Rural Midwest.
+Source
+ Cancer Epidemiology, Biomarkers & Prevention. 29(7):1321-1328, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Befort CA; Kimler BF; Bantis LE; Phillips TA; Fabian CJ
+Author NameID
+ Befort, Christie A; ORCID: https://orcid.org/0000-0003-4290-9979
+ Kimler, Bruce F; ORCID: https://orcid.org/0000-0001-7021-6964
+Authors Full Name
+ Befort, Christie A; Kimler, Bruce F; Bantis, Leonidas E; Phillips, Teresa A; Fabian, Carol J.
+Institution
+ Befort, Christie A. University of Kansas Medical Center, University of Kansas Cancer Center, Kansas City, Kansas. cbefort@kumc.edu.
+ Kimler, Bruce F. University of Kansas Medical Center, University of Kansas Cancer Center, Kansas City, Kansas.
+ Bantis, Leonidas E. University of Kansas Medical Center, University of Kansas Cancer Center, Kansas City, Kansas.
+ Phillips, Teresa A. University of Kansas Medical Center, University of Kansas Cancer Center, Kansas City, Kansas.
+ Fabian, Carol J. University of Kansas Medical Center, University of Kansas Cancer Center, Kansas City, Kansas.
+MeSH Subject Headings
+ Aged
+ *Biomarkers/me [Metabolism]
+ *Breast Neoplasms/co [Complications]
+ Breast Neoplasms/mo [Mortality]
+ Cancer Survivors
+ Female
+ Humans
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Rural Population
+ Survival Analysis
+ *Weight Gain/ph [Physiology]
+ *Weight Loss/ph [Physiology]
+Abstract
+ BACKGROUND: Obesity is associated with worse breast cancer prognosis, however little is known about the level of weight loss required to improve pathway biomarkers. The effects of weight regain on biomarkers are also largely unknown.
+
+ METHODS: Overweight/obese breast cancer survivors enrolled in an 18-month behavioral weight loss trial provided weight and serum biomarkers [leptin, adiponectin, insulin, plasminogen activator inhibitor-1 (PAI-1), IL-6, TNFalpha, and hepatocyte growth factor HGF] at baseline, 6, and 18 months (n = 138). Change in biomarkers over time and by weight loss thresholds were examined.
+
+ RESULTS: Mean weight loss at 6 months was 13.3 +/- 5.0 kg; from 6 to 18 months, mean regain was 4.0 +/- 5.2 kg. Favorable biomarker modulations were observed at 6 months for leptin, adiponectin, insulin, PAI-1, IL-6, and HGF (P < 0.006 to P < 0.0001). These changes remained significant overall at 18 months despite attenuation in some. Women who lost <10% of baseline weight showed significantly smaller modulation effects for leptin (P < 0.0001), adiponectin:leptin (A/L) ratio (P < 0.0001), PAI-1 (P < 0.001), and insulin (P = 0.003) compared with women who lost >10%. Women who lost >10% observed a significant increase in adiponectin (P < 0.0001), and these women continued to show improved adiponectin from 6 to 18 months despite weight regain. Physical activity contributed additional effects on biomarker change for leptin, A/L ratio, and PAI-1.
+
+ CONCLUSIONS: These findings are consistent with a clinical target of 10% weight.
+
+ IMPACT: Sustained increases in adiponectin likely confer benefits for breast cancer prognosis even with weight regain. Copyright ©2020 American Association for Cancer Research.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1158%2f1055-9965.EPI-19-1572
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Befort&issn=1055-9965&title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&atitle=Effects+of+Weight+Loss+and+Weight+Regain+on+Circulating+Biomarkers+in+Overweight%2FObese+Breast+Cancer+Survivors+Enrolled+in+a+Weight+Loss+Trial+in+the+Rural+Midwest.&volume=29&issue=7&spage=1321&epage=1328&date=2020&doi=10.1158%2F1055-9965.EPI-19-1572&pmid=32277008&sid=OVID:medline
+
+<1380>
+Unique Identifier
+ 32271991
+Title
+ Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter.
+Source
+ Molecular Nutrition & Food Research. 64(10):e1900818, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Beekman M; Schutte BAM; Akker EBVD; Noordam R; Dibbets-Schneider P; de Geus-Oei LF; Deelen J; Rest OV; Heemst DV; Feskens EJM; Slagboom PE
+Author NameID
+ Beekman, Marian; ORCID: https://orcid.org/0000-0003-0585-6206
+Authors Full Name
+ Beekman, Marian; Schutte, Bianca A M; Akker, Erik B van den; Noordam, Raymond; Dibbets-Schneider, Petra; de Geus-Oei, Lioe-Fee; Deelen, Joris; Rest, Ondine van de; Heemst, Diana van; Feskens, Edith J M; Slagboom, P Eline.
+Institution
+ Beekman, Marian. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.
+ Schutte, Bianca A M. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.
+ Akker, Erik B van den. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.
+ Akker, Erik B van den. The Delft Bioinformatics Lab, Delft University of Technology, Delft, 2628CD, The Netherlands.
+ Noordam, Raymond. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.
+ Dibbets-Schneider, Petra. Department of Radiology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.
+ de Geus-Oei, Lioe-Fee. Department of Radiology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.
+ Deelen, Joris. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.
+ Deelen, Joris. Max Planck Institute for Biology of Ageing, Cologne, D-50931, Germany.
+ Rest, Ondine van de. Divison of Human Nutrition and Health, Wageningen University & Research, Wageningen, 6700EV, The Netherlands.
+ Heemst, Diana van. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.
+ Feskens, Edith J M. Divison of Human Nutrition and Health, Wageningen University & Research, Wageningen, 6700EV, The Netherlands.
+ Slagboom, P Eline. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.
+MeSH Subject Headings
+ *Abdominal Fat
+ Aged
+ Biomarkers/bl [Blood]
+ Body Composition
+ Caloric Restriction
+ Female
+ *Glycerol/bl [Blood]
+ Humans
+ *Life Style
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Obesity/th [Therapy]
+Keyword Heading
+ abdominal fat
+ biomarkers
+ lifestyle interventions
+ metabolomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ SCOPE: Abdominal obesity is one of the main modifiable risk factors of age-related cardiometabolic disease. Cardiometabolic disease risk and its associated high abdominal fat mass, cholesterol, and glucose concentrations can be reduced by a healthier lifestyle. Hence, the aim is to understand the relation between lifestyle-induced changes in body composition, and specifically abdominal fat, and accompanying changes in circulating metabolic biomarkers.
+
+ METHODS AND RESULTS: Data from the Growing Old Together (GOTO) study was used, which is a single arm lifestyle intervention in which 164 older adults (mean age 63 years, BMI 23-35 kg/m2 ) changed their lifestyle during 13 weeks by 12.5% caloric restriction plus 12.5% increase in energy expenditure. It is shown here that levels of circulating metabolic biomarkers, even after adjustment for body mass index, specifically associate with abdominal fat mass. The applied lifestyle intervention mainly reduces abdominal fat mass (-2.6%, SD = 3.0) and this reduction, when adjusted for general weight loss, is highly associated with decreased circulating glycerol concentrations and increased HDL diameter.
+
+ CONCLUSION: The lifestyle-induced reduction of abdominal fat mass is particularly associated, independent of body mass index or general weight loss, with decreased circulating glycerol concentrations and increased HDL diameter. Copyright © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
+Registry Number/Name of Substance
+ 0 (Biomarkers). PDC6A3C0OX (Glycerol).
+Publication Type
+ Clinical Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1002%2fmnfr.201900818
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Beekman&issn=1613-4125&title=Molecular+Nutrition+%26+Food+Research&atitle=Lifestyle-Intervention-Induced+Reduction+of+Abdominal+Fat+Is+Reflected+by+a+Decreased+Circulating+Glycerol+Level+and+an+Increased+HDL+Diameter.&volume=64&issue=10&spage=e1900818&epage=&date=2020&doi=10.1002%2Fmnfr.201900818&pmid=32271991&sid=OVID:medline
+
+<1381>
+Unique Identifier
+ 32271180
+Title
+ Plasma Lactate as a Marker for Metabolic Health. [Review]
+Source
+ Exercise & Sport Sciences Reviews. 48(3):119-124, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Broskey NT; Zou K; Dohm GL; Houmard JA
+Authors Full Name
+ Broskey, Nicholas T; Zou, Kai; Dohm, G Lynis; Houmard, Joseph A.
+Institution
+ Zou, Kai. Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, MA.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Citric Acid Cycle
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Fasting
+ Humans
+ *Lactic Acid/bl [Blood]
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Mitochondria, Muscle/me [Metabolism]
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/bl [Blood]
+ Risk Factors
+Abstract
+ Blood lactate concentrations traditionally have been used as an index of exercise intensity or clinical hyperlactatemia. However, more recent data suggest that fasting plasma lactate can also be indicative of the risk for subsequent metabolic disease. The hypothesis presented is that fasting blood lactate accumulation reflects impaired mitochondrial substrate use, which in turn influences metabolic disease risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 33X04XA5AT (Lactic Acid).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1249%2fJES.0000000000000220
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Broskey&issn=0091-6331&title=Exercise+%26+Sport+Sciences+Reviews&atitle=Plasma+Lactate+as+a+Marker+for+Metabolic+Health.&volume=48&issue=3&spage=119&epage=124&date=2020&doi=10.1249%2FJES.0000000000000220&pmid=32271180&sid=OVID:medline
+
+<1382>
+Unique Identifier
+ 32268592
+Title
+ Effects of Regular Taekwondo Intervention on Oxidative Stress Biomarkers and Myokines in Overweight and Obese Adolescents.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 17(7), 2020 04 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Roh HT; Cho SY; So WY
+Authors Full Name
+ Roh, Hee-Tae; Cho, Su-Youn; So, Wi-Young.
+Institution
+ Roh, Hee-Tae. Department of Physical Education, College of Arts and Physical Education, Dong-A University, Busan 49315, Korea.
+ Cho, Su-Youn. Department of Taekwondo, Youngsan University, Yangsan-si 50510, Korea.
+ So, Wi-Young. Sports and Health Care Major, College of Humanities and Arts, Korea National University of Transportation, Chungju-si 27469, Korea.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ *Body Composition
+ Female
+ Humans
+ Male
+ Martial Arts/ph [Physiology]
+ *Martial Arts
+ Obesity/me [Metabolism]
+ Obesity/th [Therapy]
+ *Obesity
+ Overweight/me [Metabolism]
+ Overweight/th [Therapy]
+ *Overweight
+ Oxidative Stress
+Keyword Heading
+ adolescents
+ exercise training
+ myokine
+ obesity
+ oxidative stress
+ physical fitness
+ taekwondo
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Purpose: Regular exercise can alleviate oxidative stress related to obesity and can induce secretion of myokines that are involved in the regulation of metabolic homeostasis. There are no studies examining changes in these variables as a result of Taekwondo training intervention. We aimed to investigate the effect of Taekwondo training on oxidative stress and myokine levels in overweight and obese adolescents. Methods: We randomly assigned 20 overweight and obese adolescents to control (control group; CG, n = 10) and experimental (experimental group; EG, n = 10) groups. The EG performed Taekwondo training five times a week for 16 weeks. Physical parameters (height, weight, body mass index (BMI)), physical fitness (maximal oxygen uptake (VO2max) (cardiorespiratory endurance), grip and leg strength (muscular strength), sit-and-reach (flexibility), Sargent jump (power), and stork stand test (balance)) were measured before and after intervention. We measured levels of serum oxidative stress markers (plasma malondialdehyde (MDA) and superoxide dismutase (SOD)) and myokines (serum interleukin-15 (IL-15), brain-derived neurotrophic factor (BDNF), irisin, and myostatin). Results: The weight and BMI in the EG after intervention were significantly lower and leg strength (muscular strength), sit-and-reach (flexibility), and Sargent jump (power) were significantly improved compared to those of the CG (p < 0.05). There were no significant interaction effects in terms of height, VO2 max, grip strength, or stork stand test (p > 0.05). The SOD and BDNF level after intervention were significantly higher in the EG after the intervention, whereas MDA and irisin levels were significantly lower than those of the CG (p < 0.05). There were no significant interaction effects in terms of serum IL-15 and myostatin levels (p > 0.05). Conclusions: Taekwondo training can reduce obesity and increase physical fitness with respect to muscular strength, flexibility, and power as well as alleviate oxidative stress and modulate myokine secretion in adolescents.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijerph17072505
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Roh&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Effects+of+Regular+Taekwondo+Intervention+on+Oxidative+Stress+Biomarkers+and+Myokines+in+Overweight+and+Obese+Adolescents.&volume=17&issue=7&spage=&epage=&date=2020&doi=10.3390%2Fijerph17072505&pmid=32268592&sid=OVID:medline
+
+<1383>
+Unique Identifier
+ 32255270
+Title
+ Resistin in metabolism, inflammation, and disease. [Review]
+Source
+ FEBS Journal. 287(15):3141-3149, 2020 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tripathi D; Kant S; Pandey S; Ehtesham NZ
+Author NameID
+ Pandey, Saurabh; ORCID: https://orcid.org/0000-0002-5339-095X
+Authors Full Name
+ Tripathi, Deeksha; Kant, Sashi; Pandey, Saurabh; Ehtesham, Nasreen Z.
+Institution
+ Tripathi, Deeksha. Department of Microbiology, Central University of Rajasthan, Ajmer, Rajasthan, India.
+ Kant, Sashi. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
+ Pandey, Saurabh. Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
+ Ehtesham, Nasreen Z. Inflammation Biology and Cell Signaling Laboratory, National Institute of Pathology, New Delhi, India.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/me [Metabolism]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2/pa [Pathology]
+ Humans
+ Inflammation/me [Metabolism]
+ *Inflammation/pa [Pathology]
+ Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ *Resistin/me [Metabolism]
+Keyword Heading
+ biomarker
+ diabetes
+ inflammation
+ resistin
+ unfolded protein response
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Resistin is a small secretory protein that has a pleiotropic role in rodents and humans. Both rodent resistin and human resistin have an extremely stable and high-order multimeric structure. Moreover, there is significant variation in the source of secretion and the diversity of functions of resistin. Mouse resistin resists insulin action and contributes to type 2 diabetes mellitus, while human resistin plays a role in inflammation and also functions as a small accessory chaperone. Currently, active research in the area identified a significant role for resistin in stress biology and as a biomarker in diagnostics to evaluate disease status and treatment outcome. This review summarizes recent developments within resistin biology including their association with obesity, inflammation, stress response mechanisms, and its role in clinical diagnostics. Copyright © 2020 Federation of European Biochemical Societies.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Resistin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2ffebs.15322
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tripathi&issn=1742-464X&title=FEBS+Journal&atitle=Resistin+in+metabolism%2C+inflammation%2C+and+disease.&volume=287&issue=15&spage=3141&epage=3149&date=2020&doi=10.1111%2Ffebs.15322&pmid=32255270&sid=OVID:medline
+
+<1384>
+Unique Identifier
+ 32252654
+Title
+ Association between the ratio of serum n-3 to n-6 polyunsaturated fatty acids and acute coronary syndrome in non-obese patients with coronary risk factor: a multicenter cross-sectional study.
+Source
+ BMC Cardiovascular Disorders. 20(1):160, 2020 04 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nishizaki Y; Shimada K; Tani S; Ogawa T; Ando J; Takahashi M; Yamamoto M; Shinozaki T; Miyazaki T; Miyauchi K; Nagao K; Hirayama A; Yoshimura M; Komuro I; Nagai R; Daida H
+Authors Full Name
+ Nishizaki, Yuji; Shimada, Kazunori; Tani, Shigemasa; Ogawa, Takayuki; Ando, Jiro; Takahashi, Masao; Yamamoto, Masato; Shinozaki, Tomohiro; Miyazaki, Tetsuro; Miyauchi, Katsumi; Nagao, Ken; Hirayama, Atsushi; Yoshimura, Michihiro; Komuro, Issei; Nagai, Ryozo; Daida, Hiroyuki.
+Institution
+ Nishizaki, Yuji. Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan. ynishiza@juntendo.ac.jp.
+ Nishizaki, Yuji. Medical Technology Innovation Center, Juntendo University, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan. ynishiza@juntendo.ac.jp.
+ Shimada, Kazunori. Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
+ Tani, Shigemasa. Department of Cardiology, Nihon University Hospital, 1-6 Kanda surugadai, Chiyoda-ku, Tokyo, 101-8309, Japan.
+ Ogawa, Takayuki. Divison of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi Minato-ku, Tokyo, 105-8461, Japan.
+ Ando, Jiro. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 113-8655, Japan.
+ Takahashi, Masao. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji Shimotsuke-shi, Tochigi-ken, 329-0498, Japan.
+ Yamamoto, Masato. Department of Internal Medicine, Tokyo Takanawa Hospital, 3-10-11, Takanawa Minato-ku, Tokyo, 108-8606, Japan.
+ Shinozaki, Tomohiro. Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, Japan.
+ Miyazaki, Tetsuro. Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
+ Miyauchi, Katsumi. Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
+ Nagao, Ken. Department of Cardiology, Nihon University Hospital, 1-6 Kanda surugadai, Chiyoda-ku, Tokyo, 101-8309, Japan.
+ Hirayama, Atsushi. Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi Kamichou Itabashi-ku, Tokyo, 173-8610, Japan.
+ Yoshimura, Michihiro. Divison of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi Minato-ku, Tokyo, 105-8461, Japan.
+ Komuro, Issei. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 113-8655, Japan.
+ Nagai, Ryozo. Jichi Medical University, 3311-1 Yakushiji Shimotsuke-shi, Tochigi-ken, 329-0498, Japan.
+ Daida, Hiroyuki. Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
+ Daida, Hiroyuki. Faculty of Health Science, Juntendo University, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
+MeSH Subject Headings
+ *Acute Coronary Syndrome/bl [Blood]
+ Acute Coronary Syndrome/di [Diagnosis]
+ Acute Coronary Syndrome/ep [Epidemiology]
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ *Fatty Acids, Omega-3/bl [Blood]
+ *Fatty Acids, Omega-6/bl [Blood]
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Predictive Value of Tests
+ Prevalence
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Tokyo/ep [Epidemiology]
+Keyword Heading
+ Acute coronary syndrome
+ Arachidonic acid
+ Body mass index
+ Docosahexaenoic acid
+ Docosahexaenoic acid/arachidonic acid ratio
+ Eicosapentaenoic acid
+ Eicosapentaenoic acid/arachidonic acid ratio
+ Polyunsaturated fatty acids (PUFAs)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Previous studies have reported that being overweight, obese, or underweight is a risk factor for ischemic cardiovascular disease (CVD); however, CVD also occurs in subjects with ideal body mass index (BMI). Recently, the balance of n-3/n-6 polyunsaturated fatty acids (PUFAs) has received attention as a risk marker for CVD but, so far, no study has been conducted that investigates the association between BMI and the balance of n-3/n-6 PUFAs for CVD risk.
+
+ METHODS: We evaluated the association between n-3/n-6 PUFA ratio and acute coronary syndrome (ACS) in three BMI-based groups (< 25: low BMI, 25-27.5: moderate BMI, and >= 27.5: high BMI) that included 1666 patients who visited the cardiovascular medicine departments of five hospitals located in urban areas in Japan.
+
+ RESULTS: The prevalence of ACS events was 9.2, 7.3, and 10.3% in the low, moderate, and high BMI groups, respectively. We analyzed the relationship between ACS events and several factors, including docosahexaenoic acid/arachidonic acid (DHA/AA) ratio by multivariate logistic analyses. In the low BMI group, a history of smoking (odds ratio [OR]: 2.47, 95% confidence interval [CI]: 1.40-4.35) and low DHA/AA ratio (OR: 0.30, 95% CI: 0.12-0.74) strongly predicted ACS. These associations were also present in the moderate BMI group but the magnitude of the association was much weaker (ORs are 1.47 [95% CI: 0.54-4.01] for smoking and 0.63 [95% CI: 0.13-3.10] for DHA/AA). In the high BMI group, the association of DHA/AA (OR: 1.98, 95% CI: 0.48-8.24) was reversed and only high HbA1c (OR: 1.46, 95% CI: 1.03-2.08) strongly predicted ACS. The interaction test for OR estimates (two degrees of freedom) showed moderate evidence for reverse DHA/AA ratio-ACS associations among the BMI groups (P = 0.091).
+
+ CONCLUSIONS: DHA/AA ratio may be a useful marker for risk stratification of ACS, especially in non-obese patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Omega-3). 0 (Fatty Acids, Omega-6).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12872-020-01445-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nishizaki&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Association+between+the+ratio+of+serum+n-3+to+n-6+polyunsaturated+fatty+acids+and+acute+coronary+syndrome+in+non-obese+patients+with+coronary+risk+factor%3A+a+multicenter+cross-sectional+study.&volume=20&issue=1&spage=160&epage=&date=2020&doi=10.1186%2Fs12872-020-01445-w&pmid=32252654&sid=OVID:medline
+
+<1385>
+Unique Identifier
+ 32248760
+Title
+ The impact of a randomized dietary and physical activity intervention on chronic inflammation among obese African-American women.
+Source
+ Women & Health. 60(7):792-805, 2020 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Babatunde OA; Arp Adams S; Truman S; Sercy E MSPH; Murphy AE; Khan S MSW; Hurley TG MS; Wirth MD; Choi SK; Johnson H BA; Hebert JR ScD
+Author NameID
+ Hebert, James R ScD; ORCID: https://orcid.org/0000-0002-0677-2672
+Authors Full Name
+ Babatunde, Oluwole Adeyemi; Arp Adams, Swann; Truman, Samantha; Sercy, Erica MSPH; Murphy, Angela E; Khan, Samira MSW; Hurley, Thomas G MS; Wirth, Michael D; Choi, Seul Ki; Johnson, Hiluv BA; Hebert, James R ScD.
+Institution
+ Babatunde, Oluwole Adeyemi. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Babatunde, Oluwole Adeyemi. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
+ Babatunde, Oluwole Adeyemi. Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
+ Arp Adams, Swann. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Arp Adams, Swann. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
+ Arp Adams, Swann. College of Nursing, University of South Carolina, Columbia, South Carolina, USA.
+ Truman, Samantha. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
+ Sercy, Erica MSPH. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Murphy, Angela E. Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA.
+ Khan, Samira MSW. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Hurley, Thomas G MS. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Wirth, Michael D. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Wirth, Michael D. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
+ Wirth, Michael D. College of Nursing, University of South Carolina, Columbia, South Carolina, USA.
+ Wirth, Michael D. Connecting Health Innovations LLC, Columbia, South Carolina, USA.
+ Choi, Seul Ki. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Choi, Seul Ki. Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
+ Johnson, Hiluv BA. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Hebert, James R ScD. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
+ Hebert, James R ScD. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
+ Hebert, James R ScD. College of Nursing, University of South Carolina, Columbia, South Carolina, USA.
+ Hebert, James R ScD. Connecting Health Innovations LLC, Columbia, South Carolina, USA.
+MeSH Subject Headings
+ Adult
+ *Black or African American/sn [Statistics & Numerical Data]
+ Aged
+ Biomarkers/bl [Blood]
+ *C-Reactive Protein/an [Analysis]
+ *C-Reactive Protein/me [Metabolism]
+ Community-Based Participatory Research
+ *Diet
+ *Exercise
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/dh [Diet Therapy]
+ *Inflammation/et [Etiology]
+ *Interleukin-6/bl [Blood]
+ Life Style
+ Middle Aged
+ Obesity/dh [Diet Therapy]
+ Obesity/th [Therapy]
+ Socioeconomic Factors
+ South Carolina
+ Treatment Outcome
+Keyword Heading
+ African Americans
+ breast cancer
+ c-reactive protein
+ dietary Inflammatory Index
+ inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Lifestyle interventions may reduce inflammation and lower breast cancer (BrCa) risk. This randomized trial assessed the impact of the Sistas Inspiring Sistas Through Activity and Support (SISTAS) study on plasma C-reactive protein (CRP), interleukin-6 (IL-6) and Dietary Inflammatory Index (DII). This unblinded, dietary and physical activity trial was implemented in 337 obese (body mass index [BMI] >=30 kg/m2) African American (AA) women recruited between 2011 and 2015 in South Carolina through a community-based participatory approach with measurements at baseline, 3 months, and 12 months. Participants were randomized into either intervention (n = 176) or wait-list control group (n = 161). Linear mixed-effect models were used for analyses of CRP and IL-6. Baseline CRP was significantly higher in those with greater obesity, body fat percentage, and waist circumference (all p <.01). No difference was observed between groups for CRP or IL-6 at 3 or 12 months; however, improvements in diet were observed in the intervention group compared to the control group (p = .02) at 3 months but were not sustained at 12 months. Although the intervention was not successful at reducing levels of CRP or IL-6, a significant decrease was observed in DII score for the intervention group, indicating short-term positive dietary change.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1080%2f03630242.2020.1746950
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Babatunde&issn=0363-0242&title=Women+%26+Health&atitle=The+impact+of+a+randomized+dietary+and+physical+activity+intervention+on+chronic+inflammation+among+obese+African-American+women.&volume=60&issue=7&spage=792&epage=805&date=2020&doi=10.1080%2F03630242.2020.1746950&pmid=32248760&sid=OVID:medline
+
+<1386>
+Unique Identifier
+ 32246795
+Title
+ In vivo analysis of gammaH2AX+ cells in skeletal muscle from aged and obese humans.
+Source
+ FASEB Journal. 34(5):7018-7035, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dungan CM; Peck BD; Walton RG; Huang Z; Bamman MM; Kern PA; Peterson CA
+Authors Full Name
+ Dungan, Cory M; Peck, Bailey D; Walton, R Grace; Huang, Zhengyan; Bamman, Marcas M; Kern, Philip A; Peterson, Charlotte A.
+Institution
+ Dungan, Cory M. Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
+ Dungan, Cory M. Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.
+ Peck, Bailey D. Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
+ Peck, Bailey D. Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.
+ Walton, R Grace. Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
+ Walton, R Grace. Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.
+ Huang, Zhengyan. Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA.
+ Bamman, Marcas M. Department of Cell, Developmental, and Integrative Biology, School of Medicine, University of Alabama, Birmingham, AL, USA.
+ Bamman, Marcas M. Geriatric Research, Education, and Clinical Center, Birmingham VA Medical Center, Birmingham, AL, USA.
+ Kern, Philip A. Department of Internal Medicine/Endocrinology, College of Medicine, University of Kentucky, Lexington, KY, USA.
+ Peterson, Charlotte A. Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
+ Peterson, Charlotte A. Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ *Aging/me [Metabolism]
+ Aging/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ Cell Differentiation
+ Cellular Senescence
+ DNA Damage
+ DNA Repair/ge [Genetics]
+ Female
+ *Histones/me [Metabolism]
+ Humans
+ Immunohistochemistry
+ Male
+ Muscle Fibers, Skeletal/cy [Cytology]
+ Muscle Fibers, Skeletal/me [Metabolism]
+ *Muscle, Skeletal/me [Metabolism]
+ Myoblasts, Skeletal/cy [Cytology]
+ Myoblasts, Skeletal/me [Metabolism]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Satellite Cells, Skeletal Muscle/cy [Cytology]
+ Satellite Cells, Skeletal Muscle/me [Metabolism]
+ Young Adult
+Keyword Heading
+ DNA damage
+ postmitotic
+ satellite cells
+ senescence
+ gammaH2AX
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Over the past 20 years, various identifiers of cellular senescence have been used to quantify the abundance of these cells in different tissues. These include classic markers such as p16, senescence-associated beta-gal, and gammaH2AX, in addition to more recent markers (Sudan Black B and HMGB1). In vivo data on the usefulness of these markers in skeletal muscle are very limited and inconsistent. In the present study, we attempted to identify senescent cells in frozen human skeletal muscle biopsies using these markers to determine the effects of age and obesity on senescent cell burden; however, we were only able to assess the abundance of DNA-damaged nuclei using gammaH2AX immunohistochemistry. The abundance of gammaH2AX+ cells, including satellite cells, was not higher in muscle from old compared to young individuals; however, gammaH2AX+ cells were higher with obesity. Additionally, terminally differentiated, postmitotic myofiber nuclei from obese individuals had elevated gammaH2AX abundance compared to muscle from lean individuals. Analyses of gene expression support the conclusion that the elevated DNA damage and the senescence-associated secretory phenotype are preferentially associated with obesity in skeletal muscle. These data implicate obesity as a larger contributor to DNA damage in skeletal muscle than aging; however, more sensitive senescence markers for human skeletal muscle are needed to determine if these cells are in fact senescent. Copyright © 2020 Federation of American Societies for Experimental Biology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (H2AX protein, human). 0 (Histones).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1096%2ffj.202000111RR
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dungan&issn=0892-6638&title=FASEB+Journal&atitle=In+vivo+analysis+of+gammaH2AX%2B+cells+in+skeletal+muscle+from+aged+and+obese+humans.&volume=34&issue=5&spage=7018&epage=7035&date=2020&doi=10.1096%2Ffj.202000111RR&pmid=32246795&sid=OVID:medline
+
+<1387>
+Unique Identifier
+ 32244932
+Title
+ Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues.
+Source
+ Nutrients. 12(3), 2020 Mar 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dubois-Deruy E; Remy G; Alard J; Kervoaze G; Chwastyniak M; Baron M; Beury D; Siegwald L; Caboche S; Hot D; Gosset P; Grangette C; Pinet F; Wolowczuk I; Pichavant M
+Author NameID
+ Caboche, Segolene; ORCID: https://orcid.org/0000-0002-3658-3477
+ Hot, David; ORCID: https://orcid.org/0000-0002-2361-0616
+ Gosset, Philippe; ORCID: https://orcid.org/0000-0002-4043-6429
+ Pinet, Florence; ORCID: https://orcid.org/0000-0002-5471-1487
+Authors Full Name
+ Dubois-Deruy, Emilie; Remy, Gaelle; Alard, Jeanne; Kervoaze, Gwenola; Chwastyniak, Maggy; Baron, Morgane; Beury, Delphine; Siegwald, Lea; Caboche, Segolene; Hot, David; Gosset, Philippe; Grangette, Corinne; Pinet, Florence; Wolowczuk, Isabelle; Pichavant, Muriel.
+Institution
+ Dubois-Deruy, Emilie. University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et determinants moleculaires des maladies liees au vieillissement, F-59000 Lille, France.
+ Remy, Gaelle. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Alard, Jeanne. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Kervoaze, Gwenola. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Chwastyniak, Maggy. University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et determinants moleculaires des maladies liees au vieillissement, F-59000 Lille, France.
+ Baron, Morgane. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Beury, Delphine. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Siegwald, Lea. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Caboche, Segolene. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Hot, David. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Gosset, Philippe. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Grangette, Corinne. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Pinet, Florence. University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et determinants moleculaires des maladies liees au vieillissement, F-59000 Lille, France.
+ Wolowczuk, Isabelle. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+ Pichavant, Muriel. University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Cardiomegaly/et [Etiology]
+ Cardiomegaly/me [Metabolism]
+ Cardiomegaly/pa [Pathology]
+ Cytokines/me [Metabolism]
+ Disease Models, Animal
+ Disease Susceptibility
+ Energy Metabolism
+ *Environmental Exposure
+ Glucose/me [Metabolism]
+ Homeostasis
+ Humans
+ Insulin/me [Metabolism]
+ *Life Style
+ Lung/pp [Physiopathology]
+ Male
+ Mice
+ Microbiota
+ Obesity/co [Complications]
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Organ Specificity
+ *Smoking/ae [Adverse Effects]
+Keyword Heading
+ cigarette
+ gut
+ heart
+ lung
+ metabolism
+ microbiota
+ obesity
+ unhealthy lifestyle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Unhealthy lifestyle choices, such as bad eating behaviors and cigarette smoking, have major detrimental impacts on health. However, the inter-relations between obesity and smoking are still not fully understood. We thus developed an experimental model of high-fat diet-fed obese C57BL/6 male mice chronically exposed to cigarette smoke. Our study evaluated for the first time the resulting effects of the combined exposure to unhealthy diet and cigarette smoke on several metabolic, pulmonary, intestinal, and cardiac parameters. We showed that the chronic exposure to cigarette smoke modified the pattern of body fat distribution in favor of the visceral depots in obese mice, impaired the respiratory function, triggered pulmonary inflammation and emphysema, and was associated with gut microbiota dysbiosis, cardiac hypertrophy and myocardial fibrosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Insulin). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12030827
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dubois-Deruy&issn=2072-6643&title=Nutrients&atitle=Modelling+the+Impact+of+Chronic+Cigarette+Smoke+Exposure+in+Obese+Mice%3A+Metabolic%2C+Pulmonary%2C+Intestinal%2C+and+Cardiac+Issues.&volume=12&issue=3&spage=&epage=&date=2020&doi=10.3390%2Fnu12030827&pmid=32244932&sid=OVID:medline
+
+<1388>
+Unique Identifier
+ 32244777
+Title
+ EMS-effect of Exercises with Music on Fatness and Biomarkers of Obese Elderly Women.
+Source
+ Medicina (Kaunas, Lithuania). 56(4), 2020 Apr 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim J; Jee Y
+Authors Full Name
+ Kim, Jiyoun; Jee, Yongseok.
+Institution
+ Kim, Jiyoun. Department of Exercise Rehabilitation and Welfare, Gachon University, Hombakmoero, Yeonsu-gu, Incheon 406-799, Korea.
+ Jee, Yongseok. Department of Leisure and Marine Sports, Hanseo University, Hanseo 1-Ro, Haemi-myeon, Seosan 31962, Korea.
+MeSH Subject Headings
+ Aged
+ Biomarkers/an [Analysis]
+ Biomarkers/bl [Blood]
+ Body Composition/ph [Physiology]
+ Exercise Therapy/mt [Methods]
+ *Exercise Therapy/st [Standards]
+ Exercise Therapy/sn [Statistics & Numerical Data]
+ Female
+ Humans
+ Magnetic Field Therapy/mt [Methods]
+ *Magnetic Field Therapy/st [Standards]
+ Magnetic Field Therapy/sn [Statistics & Numerical Data]
+ *Music Therapy/is [Instrumentation]
+ Music Therapy/mt [Methods]
+ Music Therapy/st [Standards]
+ Obesity/px [Psychology]
+ *Obesity/th [Therapy]
+ Prospective Studies
+Keyword Heading
+ cytokine
+ electromyostimulation
+ exercises with music
+ percent fat
+ tumor necrosis factor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background and objectives: Electromyostimulation (EMS) has been shown to improve body composition, but what biomarkers it affects has not been investigated. The purpose of this study was to compare the EMS-effect of exercises with music on fatness and biomarker levels in obese elderly. Materials and Methods: Twenty-five women were randomly classified into a control group (CON) and EMS group (EMSG). EMS suits used in this study enabled the simultaneous activation of eight pairs with selectable intensities. Program sessions of EMS were combined with exercises of listening to music three times a week for eight weeks. Although both groups received the same program, CON did not receive electrical stimuli. Results: Compared with CON, a significant effect of the EMS intervention concerning decreased fatness, as well as an increased skeletal muscle mass and basal metabolic rate, were evident. Tumor necrosis factor-a, C-reactive protein, resistin, and carcinoembryonic antigen of biomarkers were significantly different in the groups by time interaction. Similarly, the positive changes caused by EMS were represented in lipoprotein-cholesterols. Conclusions: The results indicate that a significant effect due to the EMS intervention was found concerning body composition and biomarkers in obese elderly women.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fmedicina56040158
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1010-660X&title=Medicina+%28Kaunas%2C+Lithuania%29&atitle=EMS-effect+of+Exercises+with+Music+on+Fatness+and+Biomarkers+of+Obese+Elderly+Women.&volume=56&issue=4&spage=158&epage=&date=2020&doi=10.3390%2Fmedicina56040158&pmid=32244777&sid=OVID:medline
+
+<1389>
+Unique Identifier
+ 32244146
+Title
+ Investigation of the effects of dietary modification in experimental obesity: low dose of virgin coconut oil has a potent therapeutic value.
+Source
+ Biomedicine & Pharmacotherapy. 126:110110, 2020 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adeyemi WJ; Olayaki LA; Abdussalam TA; Toriola AP; Olowu AB; Yakub AJ; Raji AO
+Authors Full Name
+ Adeyemi, Wale Johnson; Olayaki, Luqman Aribidesi; Abdussalam, Tahir Ahmad; Toriola, Abosede Pelumi; Olowu, Akeem Babatunde; Yakub, Adebayo Jamiu; Raji, Aliu Olayinka.
+Institution
+ Adeyemi, Wale Johnson. Physiology Department, Redeemer's University, Ede, Nigeria. Electronic address: adeyemiwalej@gmail.com.
+ Olayaki, Luqman Aribidesi. Physiology Department, University of Ilorin, Ilorin, Nigeria.
+ Abdussalam, Tahir Ahmad. Anatomy and Physiology Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
+ Toriola, Abosede Pelumi. Physiology Department, University of Ilorin, Ilorin, Nigeria.
+ Olowu, Akeem Babatunde. Physiology Department, University of Ilorin, Ilorin, Nigeria.
+ Yakub, Adebayo Jamiu. Physiology Department, University of Ilorin, Ilorin, Nigeria.
+ Raji, Aliu Olayinka. Physiology Department, University of Ilorin, Ilorin, Nigeria.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Coconut Oil/ad [Administration & Dosage]
+ Coconut Oil/ch [Chemistry]
+ *Diet Therapy
+ Disease Models, Animal
+ Immunohistochemistry
+ Lipid Metabolism/de [Drug Effects]
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ *Obesity/dh [Diet Therapy]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Oxidation-Reduction/de [Drug Effects]
+ Oxidative Stress/de [Drug Effects]
+ Rats
+Keyword Heading
+ Antioxidants
+ High fat diet
+ Inflammation
+ Lipid profile
+ Liver
+ Virgin coconut oil
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ There is no report in literature on possible physiological changes that accompany dietary modification in obese condition. Moreover, there is no conclusive evidence on the optimal amount of virgin coconut oil (VCO) that could be of health benefit, although it is known to enhance lipid metabolism. Therefore, we investigated the antiobesitogenic action of graded doses of VCO (200, 400 and 600 mg/kg) in obese rats fed with normo/hyper-lipidaemic diet. Sixty rats (n = 10) were divided into 6 groups and treated as follows: the control and high fat diet (HFD) groups were administered normal saline (0.1 mL/day, p.o.) during the last four weeks of the study, and were fed with normal and HFD respectively throughout the twenty weeks duration of the experiment. Groups 3-6 were fed with HFD for 16 weeks, then normal diet during the next 4 weeks. While group - 3 received saline (0.1 mL/day, p.o.) during the last four weeks, groups 4-6 received graded doses of VCO. The results showed that HFD-induced obesity caused impaired glucose homeostasis, distorted hepatic histoarchitecture, selected deviations in hepatic function indices, pro-inflammatory, pro-oxidant, and dsylipidaemic effects. There were evidence of escalated and reversed pathological actions following the replacement of HFD with normal diet. VCO showed no effect on glucose, insulin, insulin resistance, total protein, uric acid and TAC; but equitable effects on CAT, IL-6, CRP, ALT, AST & GGT, irrespective of the dose. Compared to the effects of VCO at 400 and 600 mg/kg, at 200 mg/kg, VCO had more significant therapeutic effects on LDH, MDA, SOD, GPX, TC, TG, LDL-C, total bilirubin, atherogenic and lee indices and hepatic histoarchitecture. Conclusively, VCO, preferably at a low dose could be used to reverse hepatic structural alteration and some biochemical deviations following dietary modifications in obese condition. Copyright © 2020. Published by Elsevier Masson SAS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). Q9L0O73W7L (Coconut Oil).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.biopha.2020.110110
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adeyemi&issn=0753-3322&title=Biomedicine+%26+Pharmacotherapy&atitle=Investigation+of+the+effects+of+dietary+modification+in+experimental+obesity%3A+low+dose+of+virgin+coconut+oil+has+a+potent+therapeutic+value.&volume=126&issue=&spage=110110&epage=&date=2020&doi=10.1016%2Fj.biopha.2020.110110&pmid=32244146&sid=OVID:medline
+
+<1390>
+Unique Identifier
+ 32240196
+Title
+ Metabolic phenotyping by treatment modality in obese women with gestational diabetes suggests diverse pathophysiology: An exploratory study.
+Source
+ PLoS ONE [Electronic Resource]. 15(4):e0230658, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ White SL; Begum S; Vieira MC; Seed P; Lawlor DL; Sattar N; Nelson SM; Welsh P; Pasupathy D; Poston L
+Author NameID
+ White, Sara L; ORCID: https://orcid.org/0000-0001-7979-0508
+Corporate Author
+ UPBEAT Consortium
+Authors Full Name
+ White, Sara L; Begum, Shahina; Vieira, Matias C; Seed, Paul; Lawlor, Deborah L; Sattar, Naveed; Nelson, Scott M; Welsh, Paul; Pasupathy, Dharmintra; Poston, Lucilla.
+Institution
+ White, Sara L. Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom.
+ Begum, Shahina. Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom.
+ Vieira, Matias C. Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom.
+ Seed, Paul. Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom.
+ Lawlor, Deborah L. MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.
+ Lawlor, Deborah L. Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
+ Lawlor, Deborah L. NIHR Bristol Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, United Kingdom.
+ Sattar, Naveed. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
+ Nelson, Scott M. School of Medicine, University of Glasgow, Glasgow, United Kingdom.
+ Welsh, Paul. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
+ Pasupathy, Dharmintra. Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom.
+ Poston, Lucilla. Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Blood Glucose/an [Analysis]
+ Diabetes, Gestational/dt [Drug Therapy]
+ Diabetes, Gestational/me [Metabolism]
+ *Diabetes, Gestational/pp [Physiopathology]
+ *Diet/mt [Methods]
+ Female
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ Insulin/tu [Therapeutic Use]
+ Insulin Resistance
+ Metformin/tu [Therapeutic Use]
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Pregnancy
+ *Triglycerides/bl [Blood]
+Abstract
+ BACKGROUND AND PURPOSE: Excess insulin resistance is considered the predominant pathophysiological mechanism in obese women who develop gestational diabetes (GDM). We hypothesised that obese women requiring differing treatment modalities for GDM may have diverse underlying metabolic pathways.
+
+ METHODS: In this secondary analysis of the UK pregnancies Better Eating and Activity Trial (UPBEAT) we studied women from the control arm with complete biochemical data at three gestational time points; at 15-18+6 and 27-28+6 weeks (before treatment), and 34-36+0 weeks (after treatment). A total of 89 analytes were measured (plasma/serum) using a targeted nuclear magnetic resonance (NMR) platform and conventional assays. We used linear regression with appropriate adjustment to model metabolite concentration, stratified by treatment group.
+
+ MAIN FINDINGS: 300 women (median BMI 35kg/m2; inter quartile range 32.8-38.2) were studied. 71 developed GDM; 28 received dietary treatment only, 20 metformin, and 23 received insulin. Prior to the initiation of treatment, multiple metabolites differed (p<0.05) between the diet and insulin-treated groups, especially very large density lipoprotein (VLDL) and high density lipoprotein (HDL) subclasses and constituents, with some differences maintained at 34-36 weeks' gestation despite treatment. Gestational lipid profiles of the diet treatment group were indicative of a lower insulin resistance profile, when compared to both insulin-treated women and those without GDM. At 28 weeks' the diet treatment group had lower plasma fasting glucose and insulin than women treated with insulin, yet similar to those without GDM, consistent with a glycaemic mechanism independent of insulin resistance.
+
+ CONCLUSIONS/INTERPRETATION: This exploratory study suggests that GDM pathophysiological processes may differ amongst obese women who require different treatment modalities to achieve glucose control and can be revealed using metabolic profiling.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hypoglycemic Agents). 0 (Insulin). 0 (Triglycerides). 9100L32L2N (Metformin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1371%2fjournal.pone.0230658
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=White&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Metabolic+phenotyping+by+treatment+modality+in+obese+women+with+gestational+diabetes+suggests+diverse+pathophysiology%3A+An+exploratory+study.&volume=15&issue=4&spage=e0230658&epage=&date=2020&doi=10.1371%2Fjournal.pone.0230658&pmid=32240196&sid=OVID:medline
+
+<1391>
+Unique Identifier
+ 32231228
+Title
+ Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-Ay mice.
+Source
+ Scientific Reports. 10(1):5681, 2020 03 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Uchikawa M; Kato M; Nagata A; Sanada S; Yoshikawa Y; Tsunematsu Y; Sato M; Suzuki T; Hashidume T; Watanabe K; Yoshikawa Y; Miyoshi N
+Authors Full Name
+ Uchikawa, Misaki; Kato, Mai; Nagata, Akika; Sanada, Shunsuke; Yoshikawa, Yuto; Tsunematsu, Yuta; Sato, Michio; Suzuki, Takuji; Hashidume, Tsutomu; Watanabe, Kenji; Yoshikawa, Yuko; Miyoshi, Noriyuki.
+Institution
+ Uchikawa, Misaki. School of Food Nutritional Sciences, Shizuoka, Japan.
+ Kato, Mai. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, Shizuoka, Japan.
+ Nagata, Akika. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, Shizuoka, Japan.
+ Sanada, Shunsuke. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, Shizuoka, Japan.
+ Yoshikawa, Yuto. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, Shizuoka, Japan.
+ Tsunematsu, Yuta. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, Shizuoka, Japan.
+ Tsunematsu, Yuta. School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
+ Sato, Michio. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, Shizuoka, Japan.
+ Sato, Michio. School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
+ Suzuki, Takuji. Food Environmental Design Course, Faculty of Education, Art and Science, Yamagata University, Yamagata, Japan.
+ Hashidume, Tsutomu. School of Food Nutritional Sciences, Shizuoka, Japan.
+ Hashidume, Tsutomu. School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
+ Watanabe, Kenji. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, Shizuoka, Japan.
+ Watanabe, Kenji. School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
+ Yoshikawa, Yuko. School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
+ Yoshikawa, Yuko. School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan.
+ Miyoshi, Noriyuki. School of Food Nutritional Sciences, Shizuoka, Japan. miyoshin@u-shizuoka-ken.ac.jp.
+ Miyoshi, Noriyuki. School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan. miyoshin@u-shizuoka-ken.ac.jp.
+MeSH Subject Headings
+ Animals
+ Biomarkers/an [Analysis]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Feces/ch [Chemistry]
+ Gastrointestinal Microbiome/ge [Genetics]
+ Inflammation
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ *Obesity/me [Metabolism]
+ RAW 264.7 Cells
+ RNA, Ribosomal, 16S/ge [Genetics]
+ *Volatile Organic Compounds/an [Analysis]
+Abstract
+ When the microfloral composition deteriorates, it triggers low-level chronic inflammation associated with several lifestyle-related diseases including obesity and diabetic mellitus. Fecal volatile organic compounds (VOCs) have been found to differ in gastrointestinal diseases as well as intestinal infection. In this study, to evaluate a potential association between the pathogenesis of lifestyle-related diseases and VOCs in the intestinal tract, fecal VOCs from obese/diabetic KK-Ay mice (KK) or controls (C57BL/6J mice; BL) fed a normal or high fat diet (NFD or HFD) were investigated using headspace sampler-GC-EI-MS. Principal component analysis (PCA) of fecal VOC profiles clearly separated the experimental groups depending on the mouse lineage (KK vs BL) and the diet type (NFD vs HFD). 16 s rRNA sequencing revealed that the PCA distribution of VOCs was in parallel with the microfloral composition. We identified that some volatile metabolites including n-alkanals (nonanal and octanal), acetone and phenol were significantly increased in the HFD and/or KK groups. Additionally, these volatile metabolites induced proinflammatory activity in the RAW264 murine macrophage cell line indicating these bioactive metabolites might trigger low-level chronic inflammation. These results suggest that proinflammatory VOCs detected in HFD-fed and/or diabetic model mice might be novel noninvasive diagnosis biomarkers for diabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Ribosomal, 16S). 0 (Volatile Organic Compounds).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1038%2fs41598-020-62541-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Uchikawa&issn=2045-2322&title=Scientific+Reports&atitle=Elevated+levels+of+proinflammatory+volatile+metabolites+in+feces+of+high+fat+diet+fed+KK-Ay+mice.&volume=10&issue=1&spage=5681&epage=&date=2020&doi=10.1038%2Fs41598-020-62541-7&pmid=32231228&sid=OVID:medline
+
+<1392>
+Unique Identifier
+ 32229247
+Title
+ Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes.
+Source
+ Molecular Metabolism. 39:100983, 2020 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Russo L; Muir L; Geletka L; Delproposto J; Baker N; Flesher C; O'Rourke R; Lumeng CN
+Authors Full Name
+ Russo, Lucia; Muir, Lindsey; Geletka, Lynn; Delproposto, Jennifer; Baker, Nicki; Flesher, Carmen; O'Rourke, Robert; Lumeng, Carey N.
+Institution
+ Russo, Lucia. Department of Pediatrics, Division of Pulmonary Medicine, University of Michigan Medical School, Ann Arbor, MI, United States.
+ Muir, Lindsey. Department of Pediatrics, Division of Pulmonary Medicine, University of Michigan Medical School, Ann Arbor, MI, United States.
+ Geletka, Lynn. Department of Pediatrics, Division of Pulmonary Medicine, University of Michigan Medical School, Ann Arbor, MI, United States.
+ Delproposto, Jennifer. Department of Pediatrics, Division of Pulmonary Medicine, University of Michigan Medical School, Ann Arbor, MI, United States.
+ Baker, Nicki. Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, United States.
+ Flesher, Carmen. Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, United States.
+ O'Rourke, Robert. Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, United States.
+ Lumeng, Carey N. Department of Pediatrics, Division of Pulmonary Medicine, University of Michigan Medical School, Ann Arbor, MI, United States; Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address: clumeng@umich.edu.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ *Adipose Tissue/me [Metabolism]
+ Adult
+ Animals
+ Biomarkers
+ Cytokines/me [Metabolism]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Disease Models, Animal
+ Disease Susceptibility
+ Female
+ Gene Expression Profiling
+ Gene Expression Regulation
+ Humans
+ Insulin Resistance/ge [Genetics]
+ Macrophages/im [Immunology]
+ Macrophages/me [Metabolism]
+ Male
+ Metabolome
+ Mice
+ Mice, Knockout
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity/me [Metabolism]
+ *Panniculitis/et [Etiology]
+ Panniculitis/me [Metabolism]
+ Panniculitis/pa [Pathology]
+ Sequence Analysis, RNA
+ Signal Transduction
+ Steroid Hydroxylases/ge [Genetics]
+ *Steroid Hydroxylases/me [Metabolism]
+Keyword Heading
+ Adipose tissue
+ CH25H
+ Diabetes
+ Macrophage
+ Obesity
+ Oxysterol
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Expansion of visceral adipose tissue (VAT) and metabolic inflammation are consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically activated adipose tissue macrophages (ATMs) undergo qualitative and quantitative changes that influence their inflammatory responses. How these cells contribute to insulin resistance (IR) in humans is not well understood. Cholesterol 25-Hydroxylase (CH25H) converts cholesterol into 25-Hydroxycholesterol (25-HC), an oxysterol that modulates immune responses. Using human and murine models, we investigated the role of CH25H in metabolic inflammation.
+
+ METHODS: We performed transcriptomic (RNASeq) analysis on the human whole AT biopsies and sorted ATMs from obese non-diabetic (NDM) and obese diabetic (DM) subjects to inquire if CH25H was increased in DM. We challenged mice lacking Ch25h with a high-fat diet (HFD) to characterize their metabolic and immunologic profiling. Ch25h KO mice and human adipose tissue biopsies from NDM and DM subjects were analyzed. LC-MS was conducted to measure 25-HC level in AT. In vitro analysis permitted us to investigate the effect of 25-HC on cytokine expression.
+
+ RESULTS: In our RNASeq analysis of human visceral and subcutaneous biopsies, gene pathways related to inflammation were increased in obese DM vs. non-DM subjects that included CH25H. CH25H was enriched in the stromal vascular fraction of human adipose tissue and highly expressed in CD206+ human ATMs by flow cytometry analysis. We measured the levels of the oxysterols, 25-HC and 7alpha25diHC, in human visceral adipose tissue samples and showed a correlation between BMI and 25-HC. Using mouse models of diet-induced obesity (DIO), we found that HFD-induced Ch25h expression in eWAT and increased levels of 25-HC in AT. On HFD, Ch25h KO mice became obese but exhibited reduced plasma insulin levels, improved insulin action, and decreased ectopic lipid deposit. Improved insulin sensitivity in Ch25h KO mice was due to attenuation of CD11c+ adipose tissue macrophage infiltration in eWAT. Finally, by testing AT explants, bone marrow-derived macrophages (BMDMs) and SVF cells from Ch25h deficient mice, we observed that 25-HC is required for the expression of pro-inflammatory genes. 25-HC was also able to induce inflammatory genes in preadipocytes.
+
+ CONCLUSIONS: Our data suggest a critical role for CH25H/25-HC in the progression of meta-inflammation and insulin resistance in obese humans and mouse models of obesity. In response to obesogenic stimuli, CH25H/25-HC could exert a pro-inflammatory role. Copyright © 2020 The Authors. Published by Elsevier GmbH.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). EC 1-14 (Steroid Hydroxylases). EC 1-14-99-38 (cholesterol 25-hydroxylase).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.molmet.2020.100983
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Russo&issn=2212-8778&title=Molecular+Metabolism&atitle=Cholesterol+25-hydroxylase+%28CH25H%29+as+a+promoter+of+adipose+tissue+inflammation+in+obesity+and+diabetes.&volume=39&issue=&spage=100983&epage=&date=2020&doi=10.1016%2Fj.molmet.2020.100983&pmid=32229247&sid=OVID:medline
+
+<1393>
+Unique Identifier
+ 32228379
+Title
+ Acute Exenatide Therapy Attenuates Postprandial Vasodilation in Humans with Prediabetes: A Randomized Controlled Trial.
+Source
+ Metabolic Syndrome & Related Disorders. 18(5):225-233, 2020 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hamidi V; Riggs K; Zhu L; Bermudez Saint Andre K; Westby C; Coverdale S; Dursteler A; Wang H; Miller Iii C; Taegtmeyer H; Gutierrez AD
+Authors Full Name
+ Hamidi, Vala; Riggs, Kayla; Zhu, Liang; Bermudez Saint Andre, Karla; Westby, Christian; Coverdale, Sara; Dursteler, Amy; Wang, Hongyu; Miller Iii, Charles; Taegtmeyer, Heinrich; Gutierrez, Absalon D.
+Institution
+ Hamidi, Vala. Department of Medicine, Division of Endocrinology, University of California, San Diego, California, USA.
+ Riggs, Kayla. Department of Internal Medicine, University of Texas Southwestern, Dallas, Texas, USA.
+ Zhu, Liang. Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, Texas, USA.
+ Bermudez Saint Andre, Karla. Department of Medicine, Division of Endocrinology, Houston Methodist, Houston, Texas, USA.
+ Westby, Christian. NASA Johnson Space Center, Houston, Texas, USA.
+ Coverdale, Sara. Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, Texas, USA.
+ Dursteler, Amy. Department of Internal Medicine, University of California Los Angeles-Olive View, Los Angeles, California, USA.
+ Wang, Hongyu. Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, Texas, USA.
+ Miller Iii, Charles. Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, Texas, USA.
+ Taegtmeyer, Heinrich. Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, Texas, USA.
+ Gutierrez, Absalon D. Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, Texas, USA.
+MeSH Subject Headings
+ *Adamantane/aa [Analogs & Derivatives]
+ Adamantane/tu [Therapeutic Use]
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ Cross-Over Studies
+ Dietary Fats/ad [Administration & Dosage]
+ *Dipeptides/tu [Therapeutic Use]
+ Double-Blind Method
+ *Exenatide/tu [Therapeutic Use]
+ Female
+ *Forearm/bs [Blood Supply]
+ Humans
+ *Incretins/tu [Therapeutic Use]
+ Insulin/bl [Blood]
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Postprandial Period
+ Prediabetic State/bl [Blood]
+ Prediabetic State/di [Diagnosis]
+ *Prediabetic State/dt [Drug Therapy]
+ Prediabetic State/pp [Physiopathology]
+ Texas
+ Time Factors
+ Treatment Outcome
+ *Vasodilation/de [Drug Effects]
+Keyword Heading
+ endothelium
+ exenatide
+ postprandial
+ prediabetes
+ vasodilation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: The state of prediabetes comprises atherosclerotic changes leading to decreased vascular function in humans. This study examined the effects on incretin mimetics on vascular physiology in the prediabetic postprandial state. Methods: Fifteen obese adults with prediabetes participated in a randomized, crossover, double-blinded trial comparing the postprandial effects of exenatide, saxagliptin, and placebo on peripheral vasodilation. All studies utilized a standardized high-fat meal. Resting and peak forearm blood flow (FBF) were measured via strain gauge venous occlusion plethysmography, and makers of vascular dysfunction were measured in plasma. Results: Exenatide attenuated resting FBF at 3 hr (P = 0.003) and 6 hr (P = 0.056) postmeal, compared to placebo. Nonsignificant reductions in resting FBF were observed between saxagliptin and placebo at the same time points. No group differences were observed for peak FBF, plasma nitrotyrosine, and plasma 8-iso-prostaglandin F2alpha. A transient increase in plasma triglyceride was abated in the exenatide group, when compared to saxagliptin and placebo groups. Only exenatide group showed no significant upsurge in plasma insulin. Plasma-free fatty acids significantly declined in all three groups, although less markedly for exenatide. Postmeal glucose increased at 2 hr with placebo and saxagliptin, but simultaneously decreased with exenatide. Conclusions: Acute treatment with exenatide blunted the postprandial vasodilatory effect of a high-fat meal in prediabetes. Exenatide's acute effects derived primarily from multiple endothelium-independent processes. Trial Registration Number: NCT02104739.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Fats). 0 (Dipeptides). 0 (Incretins). 0 (Insulin). 0 (Lipids). 9GB927LAJW (saxagliptin). 9P1872D4OL (Exenatide). PJY633525U (Adamantane).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1089%2fmet.2019.0102
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hamidi&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Acute+Exenatide+Therapy+Attenuates+Postprandial+Vasodilation+in+Humans+with+Prediabetes%3A+A+Randomized+Controlled+Trial.&volume=18&issue=5&spage=225&epage=233&date=2020&doi=10.1089%2Fmet.2019.0102&pmid=32228379&sid=OVID:medline
+
+<1394>
+Unique Identifier
+ 32224637
+Title
+ Interventions for Obesity and Nutritional Status in Arthroplasty Patients. [Review]
+Source
+ JBJS Reviews. 8(3):e0161, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rahman TM; Fleifel D; Padela MT; Anoushiravani A; Rizvi SA; El-Othmani MM; Sayeed Z
+Authors Full Name
+ Rahman, Tahsin M; Fleifel, Dominik; Padela, Muhammad T; Anoushiravani, Afshin; Rizvi, Syed Ahmad; El-Othmani, Mouhanad M; Sayeed, Zain.
+Institution
+ Rahman, Tahsin M. Wayne State University School of Medicine, Detroit, Michigan.
+ Fleifel, Dominik. Wayne State University School of Medicine, Detroit, Michigan.
+ Padela, Muhammad T. Department of Orthopaedic Surgery, Detroit Medical Center, Detroit, Michigan.
+ Anoushiravani, Afshin. Department of Orthopaedic Surgery, Albany Medical Center, Albany, New York.
+ Rizvi, Syed Ahmad. Wayne State University School of Medicine, Detroit, Michigan.
+ El-Othmani, Mouhanad M. Department of Orthopaedic Surgery, Detroit Medical Center, Detroit, Michigan.
+ Sayeed, Zain. Department of Orthopaedic Surgery, Detroit Medical Center, Detroit, Michigan.
+MeSH Subject Headings
+ *Arthroplasty, Replacement
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Humans
+ Malnutrition/co [Complications]
+ Nutritional Status
+ Obesity/co [Complications]
+ *Obesity/th [Therapy]
+ Postoperative Complications/et [Etiology]
+ *Postoperative Complications/pc [Prevention & Control]
+ Weight Reduction Programs
+Abstract
+ Nutritional risk in patients undergoing total joint arthroplasty has been well-studied with regard to diagnostic criteria; however, therapeutic management of abnormal body mass index (BMI) values and serum markers remains to be studied in patients undergoing joint replacement surgery. Patients with a BMI value of >40 kg/m2 are at increased risk for postoperative complications; weight loss programs and bariatric surgery are therapeutic modalities that can be used in the prehabilitation and long-term rehabilitation of patients undergoing total joint arthroplasty. Management of patients with abnormal nutritional status should be multidisciplinary and allow for the incorporation of dietitians and nutritionists in therapeutic planning. Hypoalbuminemia correction can be completed intravenously or orally; however, arthroplasty studies remain lacking with regard to the preferred modalities of correction.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.2106%2fJBJS.RVW.19.00161
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rahman&issn=2329-9185&title=JBJS+Reviews&atitle=Interventions+for+Obesity+and+Nutritional+Status+in+Arthroplasty+Patients.&volume=8&issue=3&spage=e0161&epage=&date=2020&doi=10.2106%2FJBJS.RVW.19.00161&pmid=32224637&sid=OVID:medline
+
+<1395>
+Unique Identifier
+ 32224233
+Title
+ Increased fractalkine and vascular dysfunction in obesity and in type 2 diabetes. Effects of oral antidiabetic treatment.
+Source
+ Vascular Pharmacology. 128-129:106676, 2020 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schinzari F; Tesauro M; Campia U; Cardillo C
+Authors Full Name
+ Schinzari, Francesca; Tesauro, Manfredi; Campia, Umberto; Cardillo, Carmine.
+Institution
+ Schinzari, Francesca. Policlinico A. Gemelli IRCCS, Roma, Italy.
+ Tesauro, Manfredi. Department of Internal Medicine, Universita Tor Vergata, Roma, Italy.
+ Campia, Umberto. Vascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Cardillo, Carmine. Policlinico A. Gemelli IRCCS, Roma, Italy; Department of Internal Medicine, Universita Cattolica del Sacro Cuore, Roma, Italy. Electronic address: carmine.cardillo@unicatt.it.
+MeSH Subject Headings
+ Administration, Oral
+ Adult
+ Biomarkers/bl [Blood]
+ *Brachial Artery/de [Drug Effects]
+ Brachial Artery/pp [Physiopathology]
+ Case-Control Studies
+ *Chemokine CX3CL1/bl [Blood]
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Double-Blind Method
+ Female
+ Glyburide/ad [Administration & Dosage]
+ Humans
+ *Hypoglycemic Agents/ad [Administration & Dosage]
+ Male
+ Metformin/ad [Administration & Dosage]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Pilot Projects
+ Pioglitazone/ad [Administration & Dosage]
+ Time Factors
+ Treatment Outcome
+ *Vasodilation/de [Drug Effects]
+Keyword Heading
+ Chemokines
+ Diabetes
+ Endothelium
+ Fractalkine
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Activation of fractalkine and other chemokines plays an important role in atherogenesis and, in conjunction with endothelial dysfunction, promotes premature vascular damage in obesity and diabetes. We hypothesized that increased circulating fractalkine coexists with impaired vasomotor function in metabolically healthy or unhealthy obesity, and that treatment with antidiabetic drugs may impact these abnormalities in type 2 diabetes. Compared to lean subjects, in both obese groups the vasodilator responses to acetylcholine and sodium nitroprusside were impaired (both P < .001); ETA-receptor blockade resulted in greater vasodilation (both P < .001); and plasma levels of fractalkine, E-selectin and monocyte chemoattractant protein (MCP)-1 were increased (all P < .05). In diabetic patients, oral antidiabetic drugs (glyburide, metformin or pioglitazone) reduced circulating levels fractalkine and E-selectin (both P < .05), without affecting vascular responses (all P > .05). Our findings indicate that insulin resistant states are associated with elevated atherogenic chemokines and impaired vascular reactivity. Antidiabetic treatment results in lower circulating fractalkine, which may provide cardiovascular benefits. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CX3CL1 protein, human). 0 (Chemokine CX3CL1). 0 (Hypoglycemic Agents). 9100L32L2N (Metformin). SX6K58TVWC (Glyburide). X4OV71U42S (Pioglitazone).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.vph.2020.106676
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schinzari&issn=1537-1891&title=Vascular+Pharmacology&atitle=Increased+fractalkine+and+vascular+dysfunction+in+obesity+and+in+type+2+diabetes.+Effects+of+oral+antidiabetic+treatment.&volume=128-129&issue=&spage=106676&epage=&date=2020&doi=10.1016%2Fj.vph.2020.106676&pmid=32224233&sid=OVID:medline
+
+<1396>
+Unique Identifier
+ 32222153
+Title
+ The association between serum growth differentiation factor 15 levels and lower extremity atherosclerotic disease is independent of body mass index in type 2 diabetes.
+Source
+ Cardiovascular Diabetology. 19(1):40, 2020 03 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ He X; Su J; Ma X; Lu W; Zhu W; Wang Y; Bao Y; Zhou J
+Author NameID
+ Zhou, Jian; ORCID: https://orcid.org/0000-0002-1534-2279
+Authors Full Name
+ He, Xingxing; Su, Jiaorong; Ma, Xiaojing; Lu, Wei; Zhu, Wei; Wang, Yufei; Bao, Yuqian; Zhou, Jian.
+Institution
+ He, Xingxing. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.
+ Su, Jiaorong. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.
+ Ma, Xiaojing. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China. maxiaojing@sjtu.edu.cn.
+ Lu, Wei. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.
+ Zhu, Wei. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.
+ Wang, Yufei. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.
+ Bao, Yuqian. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.
+ Zhou, Jian. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China. zhoujian@sjtu.edu.cn.
+MeSH Subject Headings
+ Adult
+ *Atherosclerosis/bl [Blood]
+ Atherosclerosis/dg [Diagnostic Imaging]
+ Atherosclerosis/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Carotid Intima-Media Thickness
+ China/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ *Growth Differentiation Factor 15/bl [Blood]
+ Humans
+ *Lower Extremity/bs [Blood Supply]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Prognosis
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ Up-Regulation
+Keyword Heading
+ Body mass index
+ Femoral intima-media thickness
+ Growth differentiation factor 15
+ Lower extremity atherosclerotic disease
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Clinical and basic investigations have indicated a significant association between circulating growth differentiation factor 15 (GDF15) and cardiovascular disease; however, the relationship between GDF15 and lower extremity atherosclerotic disease (LEAD) has been less studied. The present study aimed to explore the association between GDF15 and LEAD in Chinese patients with type 2 diabetes mellitus (T2DM). Considering that obesity is an important factor associated with circulating GDF15 levels, whether the relationship between serum GDF15 levels and LEAD is affected by body mass index (BMI) was also analysed.
+
+ METHODS: A total of 376 hospitalized T2DM patients were enrolled (161 with LEAD and 215 without LEAD). A sandwich enzyme-linked immunosorbent assay was used to detect the serum GDF15 levels. The femoral intima-media thickness (F-IMT) and LEAD were assessed by ultrasonography.
+
+ RESULTS: Patients with LEAD had significantly higher serum GDF15 levels than those without LEAD, regardless of whether their BMI was < 25 kg/m2 or >= 25 kg/m2 (both P < 0.05). Serum GDF15 levels were independently positively related to the F-IMT (standardized beta = 0.162, P = 0.002). After adjusting for confounding factors, per 1-standard deviation (SD) increase in the serum GDF15 levels was significantly related to an approximately 1.4-fold increased risk of LEAD in the total population (P < 0.05). Regardless of whether the BMI was < 25 kg/m2 or >= 25 kg/m2, this association remained significant, with approximately 1.6- and 1.4-fold increased risks of LEAD, respectively (both P < 0.05).
+
+ CONCLUSIONS: High serum GDF15 levels were significantly correlated with an increased risk of LEAD in T2DM patients, and this relationship was independent of BMI.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (GDF15 protein, human). 0 (Growth Differentiation Factor 15).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12933-020-01020-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=He&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=The+association+between+serum+growth+differentiation+factor+15+levels+and+lower+extremity+atherosclerotic+disease+is+independent+of+body+mass+index+in+type+2+diabetes.&volume=19&issue=1&spage=40&epage=&date=2020&doi=10.1186%2Fs12933-020-01020-9&pmid=32222153&sid=OVID:medline
+
+<1397>
+Unique Identifier
+ 32220005
+Title
+ Can adipokine visfatin be a novel marker of pregnancy-related disorders in women with obesity?. [Review]
+Source
+ Obesity Reviews. 21(7):e13022, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wnuk A; Stangret A; Watroba M; Platek AE; Skoda M; Cendrowski K; Sawicki W; Szukiewicz D
+Author NameID
+ Stangret, Aleksandra; ORCID: https://orcid.org/0000-0001-9601-990X
+Authors Full Name
+ Wnuk, Anna; Stangret, Aleksandra; Watroba, Mateusz; Platek, Anna E; Skoda, Marta; Cendrowski, Krzysztof; Sawicki, Wlodzimierz; Szukiewicz, Dariusz.
+Institution
+ Wnuk, Anna. Chair and Department of Obstetrics, Gynecology and Oncology, Medical University of Warsaw, Warsaw, Poland.
+ Stangret, Aleksandra. Chair and Department of General and Experimental Pathology with Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland.
+ Watroba, Mateusz. Chair and Department of General and Experimental Pathology with Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland.
+ Platek, Anna E. Chair and Department of General and Experimental Pathology with Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland.
+ Platek, Anna E. 1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
+ Skoda, Marta. Department of Regenerative Medicine, Medical University of Warsaw, Warsaw, Poland.
+ Cendrowski, Krzysztof. Chair and Department of Obstetrics, Gynecology and Oncology, Medical University of Warsaw, Warsaw, Poland.
+ Sawicki, Wlodzimierz. Chair and Department of Obstetrics, Gynecology and Oncology, Medical University of Warsaw, Warsaw, Poland.
+ Szukiewicz, Dariusz. Chair and Department of General and Experimental Pathology with Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Female
+ Humans
+ *Nicotinamide Phosphoribosyltransferase/bl [Blood]
+ *Obesity/bl [Blood]
+ Pregnancy
+ Pregnancy Complications/bl [Blood]
+ *Pregnancy Complications/di [Diagnosis]
+Keyword Heading
+ obesity
+ pregnancy
+ visfatin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Overweight and obesity have become a dangerous disease requiring multiple interventions, treatment and preventions. In women of reproductive age, obesity is one of the most common medical conditions. Among others, obese state is characterized by low-grade systemic inflammation and enhanced oxidative stress. Increased maternal body mass index might amplify inflammation and reactive oxygen species production, which is associated with unfavourable clinical outcomes that affect both mother and child. Intrauterine growth retardation, preeclampsia, or gestational diabetes mellitus are examples of the hampered maternal and foetoplacental unit interactions. Visfatin is the obesity-related adipokine produced mainly by the visceral adipose tissue. Visfatin affects glucose homeostasis, as well as the regulation of genes related to oxidative stress and inflammatory response. Here, we review visfatin interactions in pregnancy-related disorders linked to obesity. We highlight the possible predictive and prognostic value of visfatin in diagnostic strategies on gravidas with obesity. Copyright © 2020 World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2fobr.13022
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wnuk&issn=1467-7881&title=Obesity+Reviews&atitle=Can+adipokine+visfatin+be+a+novel+marker+of+pregnancy-related+disorders+in+women+with+obesity%3F.&volume=21&issue=7&spage=e13022&epage=&date=2020&doi=10.1111%2Fobr.13022&pmid=32220005&sid=OVID:medline
+
+<1398>
+Unique Identifier
+ 32219132
+Title
+ Inflammatory Markers in Women with Polycystic Ovary Syndrome.
+Source
+ BioMed Research International. 2020:4092470, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rudnicka E; Kunicki M; Suchta K; Machura P; Grymowicz M; Smolarczyk R
+Author NameID
+ Rudnicka, E; ORCID: https://orcid.org/0000-0002-3936-5598
+ Kunicki, M; ORCID: https://orcid.org/0000-0002-0222-7909
+ Machura, P; ORCID: https://orcid.org/0000-0002-3008-1425
+ Grymowicz, M; ORCID: https://orcid.org/0000-0002-3161-0886
+Authors Full Name
+ Rudnicka, E; Kunicki, M; Suchta, K; Machura, P; Grymowicz, M; Smolarczyk, R.
+Institution
+ Rudnicka, E. Medical University of Warsaw Poland, Clinic for Gynecological Endocrinology, Poland.
+ Kunicki, M. Medical University of Warsaw Poland, Clinic for Gynecological Endocrinology, Poland.
+ Kunicki, M. Invicta Infertility Center, Warsaw, Poland.
+ Suchta, K. Department of Gynecological Endocrinology, Karowa Hospital, Warsaw, Poland.
+ Machura, P. Department of Gynecological Endocrinology, Karowa Hospital, Warsaw, Poland.
+ Grymowicz, M. Medical University of Warsaw Poland, Clinic for Gynecological Endocrinology, Poland.
+ Smolarczyk, R. Medical University of Warsaw Poland, Clinic for Gynecological Endocrinology, Poland.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Androgens
+ Androstenedione
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ Female
+ Glucose Tolerance Test
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Leukocytes
+ Obesity/co [Complications]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/co [Complications]
+ Testosterone/bl [Blood]
+ Young Adult
+Abstract
+ Several studies have reported the association between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation to be of uncertain cause: obesity, insulin resistance, or PCOS itself. The aim of the study was to investigate the WBC (white blood cell) count and CRP (C-reactive protein) concentration in women with PCOS and to determine the factors that affect their concentration. The study included 200 women aged 18-40 with PCOS and 105 healthy women as the control group, recruited in the Department of Gynaecological Endocrinology of Medical University in Warsaw from 2016 to 2018. Each patient underwent clinical, biochemical, and ultrasonographic assessments. WBC and CRP were significantly higher in the PCOS group (Z = -2,353, p = 0,019 and Z = -2,453, p = 0,014). WBC positively correlated with serum insulin at 0, 60, and 120 min during the oral glucose tolerance test (INS0: r = 0,221, p = 0,001; INS1: r = 0,194, p = 0,003; INS2: r = 0,022, p = 0,001), testosterone (r = 0,130, p = 0,046), androstenedione (r = 0,212, p = 0,001), and DHEAS (r = 0,178, p = 0,006) and negatively correlated with progesterone (r = -0,204, p = 0,002), estradiol (r = -0,140, p = 0,032), and SHBG (r = -0,308, p < 0,001). CRP positively correlated with insulin concentration in 0, 60, and 120 min during the oral glucose tolerance test (INS0: r = 0,343, p < 0,001; INS1: r = 0,276, p = 0,001; INS2: r = 0,320, p < 001) and negatively correlated with progesterone (r = -0,194, p = 0,030) and SHBG (-0,244, p = 0,005). We also estimated positive correlation between BMI and serum CRP and WBC concentration. Multiple linear regression analysis showed that CRP values are positively associated with BMI (beta = 0,374, p < 0,001) and insulin level (INS1) (beta = 0,282, p = 0,004); and WBC results are negatively associated with SHGB (beta = -0,284, p < 0,001) but positively associated with testosterone (beta = 0,163, p = 0,024) and BMI (beta = 0,157, p = 0,047). PCOS is associated with increased WBC and CRP concentrations. The main predicting factors of increased CRP are BMI and insulin resistance, but there is also a relationship between WBC count in PCOS and androgen concentration itself so that inflammation may be mediated not only through adiposity but also through increased androgen concentration. Copyright © 2020 E. Rudnicka et al.
+Registry Number/Name of Substance
+ 0 (Androgens). 0 (Biomarkers). 0 (Insulin). 3XMK78S47O (Testosterone). 409J2J96VR (Androstenedione). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1155%2f2020%2f4092470
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rudnicka&issn=2314-6141&title=BioMed+Research+International&atitle=Inflammatory+Markers+in+Women+with+Polycystic+Ovary+Syndrome.&volume=2020&issue=&spage=4092470&epage=&date=2020&doi=10.1155%2F2020%2F4092470&pmid=32219132&sid=OVID:medline
+
+<1399>
+Unique Identifier
+ 32218248
+Title
+ Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. [Review]
+Source
+ Nutrients. 12(4), 2020 Mar 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Uusitupa HM; Rasinkangas P; Lehtinen MJ; Makela SM; Airaksinen K; Anglenius H; Ouwehand AC; Maukonen J
+Authors Full Name
+ Uusitupa, Henna-Maria; Rasinkangas, Pia; Lehtinen, Markus J; Makela, Sanna M; Airaksinen, Kaisa; Anglenius, Heli; Ouwehand, Arthur C; Maukonen, Johanna.
+Institution
+ Uusitupa, Henna-Maria. DuPont Nutrition & Biosciences, Global Health and Nutrition Science, Sokeritehtaantie 20, 02460 Kantvik, Finland.
+ Rasinkangas, Pia. DuPont Nutrition & Biosciences, Global Health and Nutrition Science, Sokeritehtaantie 20, 02460 Kantvik, Finland.
+ Lehtinen, Markus J. DuPont Nutrition & Biosciences, Global Health and Nutrition Science, Sokeritehtaantie 20, 02460 Kantvik, Finland.
+ Makela, Sanna M. DuPont Nutrition & Biosciences, Global Health and Nutrition Science, Sokeritehtaantie 20, 02460 Kantvik, Finland.
+ Airaksinen, Kaisa. DuPont Nutrition & Biosciences, Global Health and Nutrition Science, Sokeritehtaantie 20, 02460 Kantvik, Finland.
+ Anglenius, Heli. DuPont Nutrition & Biosciences, Global Health and Nutrition Science, Sokeritehtaantie 20, 02460 Kantvik, Finland.
+ Ouwehand, Arthur C. DuPont Nutrition & Biosciences, Global Health and Nutrition Science, Sokeritehtaantie 20, 02460 Kantvik, Finland.
+ Maukonen, Johanna. DuPont Nutrition & Biosciences, Global Health and Nutrition Science, Sokeritehtaantie 20, 02460 Kantvik, Finland.
+MeSH Subject Headings
+ *Bifidobacterium animalis
+ Biomarkers
+ Dysbiosis
+ *Energy Metabolism
+ *Gastrointestinal Microbiome
+ Health Status
+ Heart Disease Risk Factors
+ Humans
+ Immunomodulation
+ Insulin Resistance
+ Obesity/ep [Epidemiology]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Probiotics
+ Signal Transduction
+Keyword Heading
+ B420
+ Bifidobacterium lactis
+ gut microbiota
+ metabolic health
+ metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The growing worldwide epidemic of obesity and associated metabolic health comorbidities has resulted in an urgent need for safe and efficient nutritional solutions. The research linking obesity with gut microbiota dysbiosis has led to a hypothesis that certain bacterial strains could serve as probiotics helping in weight management and metabolic health. In the search for such strains, the effect of Bifidobacterium animalis subsp. lactis 420 (B420) on gut microbiota and metabolic health, and the mechanisms of actions, has been investigated in a variety of in vitro, pre-clinical, and clinical studies. In this review, we aim to highlight the research on B420 related to obesity, metabolic health, and the microbiota. Current research supports the hypothesis that gut dysbiosis leads to an imbalance in the inflammatory processes and loss of epithelial integrity. Bacterial components, like endotoxins, that leak out of the gut can invoke low-grade, chronic, and systemic inflammation. This imbalanced state is often referred to as metabolic endotoxemia. Scientific evidence indicates that B420 can slow down many of these detrimental processes via multiple signaling pathways, as supported by mechanistic in vitro and in vivo studies. We discuss the connection of these mechanisms to clinical evidence on the effect of B420 in controlling weight gain in overweight and obese subjects. The research further indicates that B420 may improve the epithelial integrity by rebalancing a dysbiotic state induced by an obesogenic diet, for example by increasing the prevalence of lean phenotype microbes such as Akkermansia muciniphila. We further discuss, in the context of delivering the health benefits of B420: the safety and technological aspects of the strain including genomic characterization, antibiotic resistance profiling, stability in the product, and survival of the live probiotic in the intestine. In summary, we conclude that the clinical and preclinical studies on metabolic health suggest that B420 may be a potential candidate in combating obesity; however, further clinical studies are needed.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12040892
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Uusitupa&issn=2072-6643&title=Nutrients&atitle=Bifidobacterium+animalis+subsp.+lactis+420+for+Metabolic+Health%3A+Review+of+the+Research.&volume=12&issue=4&spage=&epage=&date=2020&doi=10.3390%2Fnu12040892&pmid=32218248&sid=OVID:medline
+
+<1400>
+Unique Identifier
+ 32214001
+Title
+ Relationships between Obesity, Nutrient Supply and Primary Open Angle Glaucoma in Koreans.
+Source
+ Nutrients. 12(3), 2020 Mar 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee JY; Kim JM; Lee KY; Kim B; Lee MY; Park KH
+Author NameID
+ Kim, Joon Mo; ORCID: https://orcid.org/0000-0002-4543-043X
+ Lee, Mi Yeon; ORCID: https://orcid.org/0000-0003-2119-9226
+Authors Full Name
+ Lee, Jae Yeun; Kim, Joon Mo; Lee, Kyoung Yong; Kim, Bokyung; Lee, Mi Yeon; Park, Ki Ho.
+Institution
+ Lee, Jae Yeun. Department of Ophthalmology, Sahmyook Medical Center, Seoul 02500, Korea.
+ Kim, Joon Mo. Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
+ Lee, Kyoung Yong. Department of Ophthalmology, Sahmyook Medical Center, Seoul 02500, Korea.
+ Kim, Bokyung. Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
+ Lee, Mi Yeon. Division of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
+ Park, Ki Ho. Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Mass Index
+ Comorbidity
+ Cross-Sectional Studies
+ Female
+ Glaucoma, Open-Angle/di [Diagnosis]
+ *Glaucoma, Open-Angle/ep [Epidemiology]
+ *Glaucoma, Open-Angle/et [Etiology]
+ Humans
+ Intraocular Pressure
+ Male
+ Middle Aged
+ *Nutrients
+ Nutritional Status
+ *Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ Public Health Surveillance
+ Republic of Korea/ep [Epidemiology]
+Keyword Heading
+ body mass index
+ diet
+ glaucoma
+ nutrition
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ To investigate the association between nutrient intake and primary open angle glaucoma (POAG) in Koreans, a population-based, cross-sectional survey, the Korean National Health and Nutrition Examination Survey, was analyzed. Glaucoma diagnosis was based on criteria established by the International Society of Geographic and Epidemiologic Ophthalmology. Multivariate regression analysis was used to assess the correlation between dietary intake and the prevalence of POAG in all enrolled subjects. In the low Body mass index(BMI) group (BMI <18.5), females with POAG had significantly lower intakes of energy, protein, fat, carbohydrate, ash, calcium, phosphorus, sodium, potassium, vitamin A, B-carotene, thiamin, riboflavin, and vitamin C than their non-glaucoma counterparts, based on a multivariate logistic regression analysis (all p < 0.05). In females with a medium BMI (18.5 <= BMI < 23), POAG showed a significant association with lower food intake, energy, protein, calcium, phosphorus, potassium, thiamin and niacin. (all p < 0.05). Lower protein thiamine intake in medium BMI males was related to POAG. Low dietary intake of several nutrients showed an association with glaucoma in low BMI female subjects. An insufficient intake of certain nutrients may be associated with an increased risk of glaucoma in Koreans. Further large-scale cohort studies are needed to determine how specific nutrients alter the risk of glaucoma.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12030878
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=2072-6643&title=Nutrients&atitle=Relationships+between+Obesity%2C+Nutrient+Supply+and+Primary+Open+Angle+Glaucoma+in+Koreans.&volume=12&issue=3&spage=&epage=&date=2020&doi=10.3390%2Fnu12030878&pmid=32214001&sid=OVID:medline
+
+<1401>
+Unique Identifier
+ 32210144
+Title
+ Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice.
+Source
+ International Journal of Molecular Sciences. 21(6), 2020 Mar 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kato J; Shirakami Y; Mizutani T; Kubota M; Sakai H; Ibuka T; Shimizu M
+Authors Full Name
+ Kato, Junichi; Shirakami, Yohei; Mizutani, Taku; Kubota, Masaya; Sakai, Hiroyasu; Ibuka, Takashi; Shimizu, Masahito.
+Institution
+ Kato, Junichi. Departments of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
+ Shirakami, Yohei. Departments of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
+ Shirakami, Yohei. Informative Clinical Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
+ Mizutani, Taku. Departments of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
+ Kubota, Masaya. Departments of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
+ Sakai, Hiroyasu. Departments of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
+ Ibuka, Takashi. Departments of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
+ Shimizu, Masahito. Departments of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
+MeSH Subject Headings
+ Animals
+ Antioxidants/ch [Chemistry]
+ Antioxidants/pd [Pharmacology]
+ Azoxymethane/ae [Adverse Effects]
+ Biomarkers
+ Biopsy
+ Cell Proliferation/de [Drug Effects]
+ Colonic Neoplasms/dt [Drug Therapy]
+ *Colonic Neoplasms/et [Etiology]
+ *Colonic Neoplasms/pa [Pathology]
+ Cytokines/me [Metabolism]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Disease Models, Animal
+ *Glycoside Hydrolase Inhibitors/ch [Chemistry]
+ *Glycoside Hydrolase Inhibitors/pd [Pharmacology]
+ Humans
+ Inflammation Mediators
+ *Inositol/aa [Analogs & Derivatives]
+ Inositol/ch [Chemistry]
+ Inositol/pd [Pharmacology]
+ Intestinal Mucosa/de [Drug Effects]
+ Intestinal Mucosa/me [Metabolism]
+ Intestinal Mucosa/pa [Pathology]
+ Mice
+ NF-kappa B/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Oxidative Stress/de [Drug Effects]
+ Precancerous Conditions
+Keyword Heading
+ alpha-glucosidase inhibitor
+ colorectal cancer
+ diabetes mellitus
+ obesity
+ voglibose
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Type 2 diabetes mellitus and its related insulin resistance are known to increase the risk of cancer. Anti-diabetic agents can improve insulin resistance and may lead to the suppression of carcinogenesis. This study aimed to investigate the preventive effects of the alpha-glucosidase inhibitor voglibose on the development of azoxymethane-induced colorectal pre-neoplastic lesions in obese and diabetic C57BL/KsJ-db/db mice. The direct effects of voglibose on the proliferation of colorectal cancer cells were also evaluated. Mice were injected with azoxymethane to induce colorectal pre-malignancy and were then administered drinking water with or without voglibose. At the end of the study, the administration of voglibose significantly suppressed the development of colorectal neoplastic lesions. In voglibose-treated mice, serum glucose levels, oxidative stress, as well as mRNA expression of the insulin-like growth factor-1 in the colon mucosa, were reduced. The proliferation of human colorectal cancer cells was not altered by voglibose. These results suggested that voglibose suppressed colorectal carcinogenesis in a diabetes- and obesity-related colorectal cancer model, presumably by improving inflammation via the reduction of oxidative stress and suppressing of the insulin-like growth factor/insulin-like growth factor-1 receptor axis in the colonic mucosa.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Cytokines). 0 (Glycoside Hydrolase Inhibitors). 0 (Inflammation Mediators). 0 (NF-kappa B). 4L6452S749 (Inositol). MO0N1J0SEN (Azoxymethane). S77P977AG8 (voglibose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijms21062226
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kato&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Alpha-Glucosidase+Inhibitor+Voglibose+Suppresses+Azoxymethane-Induced+Colonic+Preneoplastic+Lesions+in+Diabetic+and+Obese+Mice.&volume=21&issue=6&spage=2226&epage=&date=2020&doi=10.3390%2Fijms21062226&pmid=32210144&sid=OVID:medline
+
+<1402>
+Unique Identifier
+ 32207310
+Title
+ Assessment of renal function in obese and overweight children with NGAL and KIM-1 biomarkers.
+Original Title
+ Valoracion de la funcion renal en ninos con sobrepeso y obesidad con las moleculas NGAL y KIM-1.
+Source
+ Nutricion Hospitalaria. 34(3):436-442, 2020 Jul 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gul A; Yilmaz R; Ozmen ZC; Gumuser R; Demir O; Unsal V
+Authors Full Name
+ Gul, Ali; Yilmaz, Resul; Ozmen, Zeliha Cansel; Gumuser, Ruveyda; Demir, Osman; Unsal, Velid.
+Institution
+ Gul, Ali. Department of Pediatrics. Gaziosmanpasa University School of Medicine.
+ Yilmaz, Resul. Department of Pediatrics. Selcuklu University School of Medicine.
+ Ozmen, Zeliha Cansel. Department of Biochemistry. Gaziosmanpasa University School of Medicine.
+ Gumuser, Ruveyda. Department of Biostatistics. Gaziosmanpasa University School of Medicine.
+ Demir, Osman. Department of Biostatistics. Gaziosmanpasa University School of Medicine.
+ Unsal, Velid. Department of Nutrition and Dietetics. Mardin Artuklu University School of Health.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/ur [Urine]
+ Child
+ Cholesterol, LDL/bl [Blood]
+ Dyslipidemias/ur [Urine]
+ Female
+ *Hepatitis A Virus Cellular Receptor 1/an [Analysis]
+ Humans
+ Insulin Resistance
+ Kidney Diseases/et [Etiology]
+ *Kidney Diseases/ur [Urine]
+ *Kidney Function Tests
+ *Lipocalin-2/ur [Urine]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ur [Urine]
+ Obesity/co [Complications]
+ *Obesity/pp [Physiopathology]
+ Overweight/co [Complications]
+ *Overweight/pp [Physiopathology]
+Keyword Heading
+ Obesidad infantil. Sindrome metabolico. NGLA. KIM-1. Dano renal.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Aim and background: the incidence of obesity has increased among children, and obesity has been considered an independent risk factor for chronic kidney disease. We aimed to determine the degree of kidney function impairment by evaluating urine neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels. Materials and methods: in total, 15 obese, 26 overweight, and 26 control adolescents aged 10 to 16 years were enrolled into the study. Urine samples were evaluated for NGAL and KIM-1 levels using enzyme-linked immunosorbent assay kits. We investigated the association between obesity and related comorbidities with urinary NGAL and KIM-1 excretion. Results: no significant differences were noted between the obese, overweight, and control groups in urinary NGAL and KIM-1 excretion (p = 0.327 and p = 0.917, respectively). In the obese and overweight groups urinary NGAL levels were 50.39 [30.88-74.22] in females and 26.67 [23.24-45.59] in males (p = 0.013). Also, urinary NGAL levels were increased in obese and overweight adolescents with LDL dyslipidemia at 64.12 [30.98-114.32] as compared to those without LDL dyslipidemia: 39.51 [25.59.56.37] (p = 0.024). Furthermore, a correlation was observed between insulin and homeostasis model assessment of insulin resistance levels with the NGAL/creatinine ratio in the overweight group (r = 0.515; p = 0.008, and r = 0.483; p = 0.014, respectively). Such correlation was not found in the obese group. Conclusion : the effect of obesity on renal function could not be determined in children. A longer exposure may be required for obesity-induced disruption of renal function in children. Renal function may be disrupted by dyslipidemia in obese adolescents. Furthermore, obesity impaired renal function in female adolescents. The normalization of these urinary markers as related to urine creatinine should be discussed.
+Other Abstract
+ Publisher
+ INTRODUCCION: Introduccion: la incidencia de la obesidad en la edad infantil ha aumentado. Se considera la obesidad como un factor de riesgo independiente para el desarrollo de la enfermedad renal cronica. El objetivo de este estudio fue valorar el grado de alteracion de la funcion renal evaluando los niveles urinarios de NGAL y KIM-1. Material y metodos: el estudio incluyo a 15 adolescentes con obesidad, 26 con sobrepeso y 26 controles sanos.Edades de los participantes entre los 10 y los 16 anos. Los niveles de NGAL y KIM-1 en orina se determinaron mediante kit ELISA. Se investigo asociacion entre obesidad y su comorbilidad con excrecion urinaria de NGAL y KIM-1. Resultados: no se encontraron diferencias significativas en la excrecion urinaria de NGAL y KIM-1 entre los sujetos con obesidad, los sujetos con sobrepeso y los controles sanos (p = 0,327 y 0,917, respectivamente). En el grupo con sobrepeso y obesidad, los niveles de NGAL en las ninas fueron de 50,39 (30,88-74,22), mientras que en los ninos fueron de 26,67 (23,24-45,59) (p = 0,013). Para los sujetos con dislipemia de LDL, el nivel de NGAL fue de 64,12 (30,98-114,32) frente a 39,5 (25,59-56,37) entre los que no la tenian (p = 0,024). Se encontro correlacion entre los nivles de insulina, el HOMA-IR y la ratio NGAL/creatinina en el grupo con sobrepeso (r = 0,515; p = 0,008, y r = 0,483; p = 0,014, respectivamente). En el grupo con obesidad no se encontro dicha correlacion. Conclusiones: se precisa una duracion mas prolongada para encontrar alterada la funcion renal en los ninos con exceso de peso. La funcion renal puede alterarse por la dislipemia en el caso de los adolescentes con obesidad. La funcion renal se afecta mas en las adolescentes femeninas.
+ Language: Spanish
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL). 0 (HAVCR1 protein, human). 0 (Hepatitis A Virus Cellular Receptor 1). 0 (LCN2 protein, human). 0 (Lipocalin-2).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.20960%2fnh.02651
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gul&issn=0212-1611&title=Nutricion+Hospitalaria&atitle=Valoracion+de+la+funcion+renal+en+ninos+con+sobrepeso+y+obesidad+con+las+moleculas+NGAL+y+KIM-1.&volume=34&issue=3&spage=436&epage=442&date=2020&doi=10.20960%2Fnh.02651&pmid=32207310&sid=OVID:medline
+
+<1403>
+Unique Identifier
+ 32200256
+Title
+ Thyme oxymel by improving of inflammation, oxidative stress, dyslipidemia and homeostasis of some trace elements ameliorates obesity induced by high-fructose/fat diet in male rat.
+Source
+ Biomedicine & Pharmacotherapy. 126:110079, 2020 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nimrouzi M; Abolghasemi J; Sharifi MH; Nasiri K; Akbari A
+Authors Full Name
+ Nimrouzi, Majid; Abolghasemi, Jafar; Sharifi, Mohammad Hossein; Nasiri, Khadijeh; Akbari, Abolfazl.
+Institution
+ Nimrouzi, Majid. Department of Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
+ Abolghasemi, Jafar. Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
+ Sharifi, Mohammad Hossein. Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
+ Nasiri, Khadijeh. Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran.
+ Akbari, Abolfazl. Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. Electronic address: A.akbari@shirazu.ac.ir.
+MeSH Subject Headings
+ Animals
+ Anti-Inflammatory Agents/ch [Chemistry]
+ *Anti-Inflammatory Agents/pd [Pharmacology]
+ Antioxidants/ch [Chemistry]
+ *Antioxidants/pd [Pharmacology]
+ Biomarkers
+ Blood Glucose/de [Drug Effects]
+ Chromatography, High Pressure Liquid
+ Diet, High-Fat
+ Disease Models, Animal
+ Fructose/ad [Administration & Dosage]
+ Fructose/me [Metabolism]
+ Gas Chromatography-Mass Spectrometry
+ Gene Expression
+ *Homeostasis/de [Drug Effects]
+ Hypolipidemic Agents/ch [Chemistry]
+ *Hypolipidemic Agents/pd [Pharmacology]
+ Immunohistochemistry
+ Inflammation Mediators/me [Metabolism]
+ Lipid Metabolism/de [Drug Effects]
+ Male
+ *Medicine, Traditional
+ Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Oxidative Stress/de [Drug Effects]
+ Rats
+ *Trace Elements/me [Metabolism]
+Keyword Heading
+ Inflammation
+ Lipid metabolism
+ Obesity
+ Oxidative stress
+ Thyme oxymel
+ Traces elements
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Thyme oxymel is a mixture of vinegar, sugar and thyme which is traditionally used in many folk medicines as syrup to treat metabolic disorders. The molecular mechanisms of anti-hyperlipidemic and anti-inflammatory and antioxidant effects of thyme oxymel or oxymel and its role on homeostasis of trace elements are not fully understood. The aim of this study was to evaluate the anti-inflammatory, antioxidant and anti- hyperlipidemic effects of different doses of thyme oxymel and oxymel on obesity induced by high-fat/-fructose diet (HFFD) in male rat.
+
+ METHODS: Eighty adult male Sprague-Dawley rats were randomly divided into eleven groups and treated daily for 24 weeks. At the end of the study, serum levels of liver enzymes, lipid profiles, blood glucose, insulin, antioxidant enzymes and lipid peroxidation and TNF-alpha were measured. The hepatic oxidative biomarkers and the genes expression of SREBP-1c, CPT-1, Nrf-2 and NF-kappaB were also studied to determine the molecular mechanism involved in this disease.
+
+ RESULTS: The results showed that HFFD could significantly change the level of oxidative biomarkers, lipid profiles, TNF-alpha, liver enzymes, leptin, insulin and the levels of some trace elements in obese rats compared to control group (p < 0.05), while pretreatment and treatment with thyme oxymel and oxymel in obese rats could significantly ameliorate them and bring some of them back to normal (p < 0.05). The molecular results also showed that HFFD significantly up-regulated the expression of SREBP-1c and NF-kappaB and down-regulated CPT-1 and Nrf-2 expression(p < 0.05). While, pretreatment and treatment with thyme oxymel or oxymel in obese rats could significantly ameliorate them (p < 0.05).
+
+ CONCLUSIONS: It can be concluded that thyme oxymel or oxymel can alleviate HFFD-induced obesity through improving oxidative stress, inflammation, lipid metabolism, homeostasis of some trace elements, and weight-regulating hormones. Copyright © 2020. Published by Elsevier Masson SAS.
+Registry Number/Name of Substance
+ 0 (Anti-Inflammatory Agents). 0 (Antioxidants). 0 (Biomarkers). 0 (Blood Glucose). 0 (Hypolipidemic Agents). 0 (Inflammation Mediators). 0 (Trace Elements). 30237-26-4 (Fructose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.biopha.2020.110079
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nimrouzi&issn=0753-3322&title=Biomedicine+%26+Pharmacotherapy&atitle=Thyme+oxymel+by+improving+of+inflammation%2C+oxidative+stress%2C+dyslipidemia+and+homeostasis+of+some+trace+elements+ameliorates+obesity+induced+by+high-fructose%2Ffat+diet+in+male+rat.&volume=126&issue=&spage=110079&epage=&date=2020&doi=10.1016%2Fj.biopha.2020.110079&pmid=32200256&sid=OVID:medline
+
+<1404>
+Unique Identifier
+ 32200253
+Title
+ Angiogenesis in obesity. [Review]
+Source
+ Biomedicine & Pharmacotherapy. 126:110103, 2020 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nijhawans P; Behl T; Bhardwaj S
+Authors Full Name
+ Nijhawans, Priya; Behl, Tapan; Bhardwaj, Shaveta.
+Institution
+ Nijhawans, Priya. Chitkara College of Pharmacy, Chitkara University, Punjab, India.
+ Behl, Tapan. Chitkara College of Pharmacy, Chitkara University, Punjab, India. Electronic address: tapan.behl@chitkara.edu.in.
+ Bhardwaj, Shaveta. GHG Khalsa College of Pharmacy, Punjab, India.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pa [Pathology]
+ Animals
+ Biomarkers
+ Humans
+ *Neovascularization, Pathologic
+ *Neovascularization, Physiologic
+ *Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ Obesity/th [Therapy]
+ Receptors, Notch/me [Metabolism]
+ Vascular Endothelial Growth Factor A/ge [Genetics]
+ Vascular Endothelial Growth Factor A/me [Metabolism]
+Keyword Heading
+ Adipose tissue
+ Angiogenesis
+ Endothelial cells
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Angiogenesis is considered as a major progenitor in the progression of obesity. The current manuscript enumerates the extrinsic role of angiogenesis in obesity.
+
+ RESULT: High caloric diet and lack of physical exercise are the most common causes of obesity and related metabolic conditions. A grossly elevated levels of fat in adipose tissue escalate certain complications which further worsen the state of obesity. Enlargement of white adipose tissue (WAT), deposition of fat mass, proliferation of endothelial cells, production of inflammatory cytokines induces the formation of denovo capillaries from parent microvasculature. Also, several intracellular signaling pathways precipitate obesity. Though, angiostatic molecules (endostatin, angiostatin and TNP-470) have been designed to combat obesity and associated complications.
+
+ CONCLUSION: Adipose tissue trigger growth of blood capillaries, and in turn adipose tissue endothelial cells promote pre-adipocyte proliferation. Modulation of angiogenesis and treatment with angiostatic substances may have the potential to impair the progression of obesity. Copyright © 2020. Published by Elsevier Masson SAS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Receptors, Notch). 0 (Vascular Endothelial Growth Factor A).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.biopha.2020.110103
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nijhawans&issn=0753-3322&title=Biomedicine+%26+Pharmacotherapy&atitle=Angiogenesis+in+obesity.&volume=126&issue=&spage=110103&epage=&date=2020&doi=10.1016%2Fj.biopha.2020.110103&pmid=32200253&sid=OVID:medline
+
+<1405>
+Unique Identifier
+ 32198598
+Title
+ Cardioprotective properties of leptin in patients with excessive body mass.
+Source
+ Irish Journal of Medical Science. 189(4):1259-1265, 2020 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Paduszynska A; Sakowicz A; Banach M; Maciejewski M; Dabrowa M; Bielecka-Dabrowa A
+Authors Full Name
+ Paduszynska, Aleksandra; Sakowicz, Agata; Banach, Maciej; Maciejewski, Marek; Dabrowa, Marek; Bielecka-Dabrowa, Agata.
+Institution
+ Paduszynska, Aleksandra. Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.
+ Sakowicz, Agata. Department of Medical Biotechnology, Medical University of Lodz, Lodz, Poland.
+ Banach, Maciej. Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.
+ Banach, Maciej. Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
+ Maciejewski, Marek. Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
+ Dabrowa, Marek. Department of Biopharmacy, Chair of Biopharmacy, Medical University of Lodz, Lodz, Poland.
+ Bielecka-Dabrowa, Agata. Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland. agatbiel7@poczta.onet.pl.
+ Bielecka-Dabrowa, Agata. Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. agatbiel7@poczta.onet.pl.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ *Adipokines/ae [Adverse Effects]
+ *Adipose Tissue/pp [Physiopathology]
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Cardiotonic Agents/bl [Blood]
+ *Cardiovascular Diseases/pp [Physiopathology]
+ Female
+ Humans
+ *Leptin/ch [Chemistry]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+Keyword Heading
+ Adipokines
+ Hypertrophy
+ Left ventricular remodeling
+ Leptin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Adipose tissue is producing adipokines that play different roles in the pathophysiology of cardiovascular disease.
+
+ AIMS: The study aimed to assess the role of selected biomarkers in hypertensive patients with overweight and obesity compared with those with normal body-mass index (BMI).
+
+ METHODS: A total of 62 patients with BMI < 25 kg/m2 (median age 54 (46-58) yrs., 57% males) and 51 with BMI >= 25 kg/m2 (median age 53 (48-59) yrs., 37% males) were enrolled. Biochemical parameters, leptin, adiponectin, and resistin; asymmetric dimethylarginine; interleukin 6; and N-terminal propeptide of type III procollagen, were assessed in plasma. The evaluation of hemodynamic parameters was performed using SphygmoCor 9.0 tonometer. Echocardiography was performed using AlokaAlpha 10 Premier device.
+
+ RESULTS: Overweight and obese patients had significantly higher concentration of leptin (34 vs 18 ng/ml; p = 0.03), ADMA (0.43 vs 0.38 mumol/l, p = 0.04), and lower concentration of adiponectin (5.3 vs 7 mug/ml, p = 0.01). The only significant difference in tonometry analysis was higher aortic pulse pressure (mmHg) in patients with BMI >= 25 kg/m2 group (34 vs 30; p = 0.03). These patients had also significantly lower peak systolic velocity and early diastolic velocity in tissue Doppler imaging of the right ventricle free wall at the level of the tricuspid annulus compared with controls (p = 0.02 and p = 0.001, respectively). The level of leptin is correlated negatively with the left ventricular mass index (LVMI) (R Spearman = - 0.5; p = 0.002) and PWV (R = - 0.4; p = 0.01) and ADMA with total and LDL cholesterol (R = - 0.42; p = 0.008), and adiponectin is correlated positively with HDL cholesterol (R = 0.67; p = 0.0001).
+
+ CONCLUSIONS: Leptin concentrations were inversely proportional to LVMI and PWV in patients with BMI < 25 kg/m2.
+
+ TRIAL REGISTRATION: Clinicaltrials.gov study ID: NCT04175080.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cardiotonic Agents). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs11845-020-02211-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Paduszynska&issn=0021-1265&title=Irish+Journal+of+Medical+Science&atitle=Cardioprotective+properties+of+leptin+in+patients+with+excessive+body+mass.&volume=189&issue=4&spage=1259&epage=1265&date=2020&doi=10.1007%2Fs11845-020-02211-9&pmid=32198598&sid=OVID:medline
+
+<1406>
+Unique Identifier
+ 32192153
+Title
+ Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity.
+Source
+ International Journal of Molecular Sciences. 21(6), 2020 Mar 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khadir A; Kavalakatt S; Madhu D; Cherian P; Al-Mulla F; Abubaker J; Tiss A
+Author NameID
+ Al-Mulla, Fahd; ORCID: https://orcid.org/0000-0001-5409-3829
+Authors Full Name
+ Khadir, Abdelkrim; Kavalakatt, Sina; Madhu, Dhanya; Cherian, Preethi; Al-Mulla, Fahd; Abubaker, Jehad; Tiss, Ali.
+Institution
+ Khadir, Abdelkrim. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Kavalakatt, Sina. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Madhu, Dhanya. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Cherian, Preethi. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Al-Mulla, Fahd. Research Division, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Abubaker, Jehad. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+ Tiss, Ali. Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, Kuwait City 15462, Kuwait.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Weights and Measures
+ Endoplasmic Reticulum Chaperone BiP
+ *Epoxide Hydrolases/ge [Genetics]
+ Epoxide Hydrolases/me [Metabolism]
+ *Exercise
+ Female
+ *Gene Expression Regulation
+ Humans
+ Leukocytes, Mononuclear/me [Metabolism]
+ Male
+ Middle Aged
+ *Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+ Subcutaneous Fat/me [Metabolism]
+Keyword Heading
+ EPHX2
+ diabetes
+ exercise
+ obesity
+ sEH
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Epoxide hydrolase 2 (EPHX2) is an emerging therapeutic target in several immunometabolic disorders. EPHX2 metabolizes anti-inflammatory epoxyeicosatrienoic acids into pro-inflammatory diols. The contribution of EPHX2 activity to human obesity remains unexplored. We compared the expression of EPHX2 between lean and obese humans (n = 20 each) in subcutaneous adipose tissue (SAT) and peripheral blood mononuclear cells (PBMCs) using RT-PCR, Western Blot analysis, immunohistochemistry, and confocal microscopy before and after a 3-month physical activity regimen. We also assessed EPHX2 levels during preadipocyte differentiation in humans and mice. EPHX2 mRNA and protein expression were significantly elevated in obese subjects, with concomitant elevated endoplasmic reticulum (ER) stress components (the 78-kDa glucose-regulated protein; GRP78, and the Activating transcription factor 6; ATF6) and inflammatory markers (Tumor necrosis factor-alpha; TNFalpha, and Interleukin 6; IL6) as compared to controls (p < 0.05). EPHX2 mRNA levels strongly correlated with adiposity markers. In obese individuals, physical activity attenuated EPHX2 expression levels in both the SAT and PBMCs, with a parallel decrease in ER stress and inflammation markers. EPHX2 expression was also elevated during differentiation of both human primary and 3T3-L1 mouse preadipocytes. Mediators of cellular stress (palmitate, homocysteine, and macrophage culture medium) also increased EPHX2 expression in 3T3-L1 preadipocytes. Our findings suggest that EPHX2 upregulation is linked to ER stress in adiposity and that physical activity may attenuate metabolic stress by reducing EPHX2 expression.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Endoplasmic Reticulum Chaperone BiP). 0 (HSPA5 protein, human). 0 (Hspa5 protein, mouse). 0 (RNA, Messenger). EC 3-3-2 (Epoxide Hydrolases). EC 3-3-2-10 (EPHX2 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijms21062056
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khadir&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Soluble+Epoxide+Hydrolase+2+Expression+Is+Elevated+in+Obese+Humans+and+Decreased+by+Physical+Activity.&volume=21&issue=6&spage=2056&epage=&date=2020&doi=10.3390%2Fijms21062056&pmid=32192153&sid=OVID:medline
+
+<1407>
+Unique Identifier
+ 32188105
+Title
+ Enhanced Adipose Expression of Interferon Regulatory Factor (IRF)-5 Associates with the Signatures of Metabolic Inflammation in Diabetic Obese Patients.
+Source
+ Cells. 9(3), 2020 03 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sindhu S; Kochumon S; Thomas R; Bennakhi A; Al-Mulla F; Ahmad R
+Authors Full Name
+ Sindhu, Sardar; Kochumon, Shihab; Thomas, Reeby; Bennakhi, Abdullah; Al-Mulla, Fahd; Ahmad, Rasheed.
+Institution
+ Sindhu, Sardar. Animal & Imaging Core Facility, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Kochumon, Shihab. Immunology & Microbiology, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Thomas, Reeby. Immunology & Microbiology, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Bennakhi, Abdullah. Medical division, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Al-Mulla, Fahd. Genetics & Bioinformatics, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Ahmad, Rasheed. Immunology & Microbiology, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Adult
+ Biomarkers/me [Metabolism]
+ Diabetes Complications
+ *Diabetes Mellitus/me [Metabolism]
+ Female
+ Gene Expression Regulation/ph [Physiology]
+ Humans
+ Inflammation/co [Complications]
+ *Inflammation/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ Interferon Regulatory Factors/ge [Genetics]
+ *Interferon Regulatory Factors/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+Keyword Heading
+ Interferon regulatory factor-5
+ adipose tissue
+ metabolic inflammation
+ obesity
+ type-2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ : Interferon regulatory factors (IRFs) are emerging as the metabolic transcriptional regulators in obesity/type-2 diabetes (T2D). IRF5 is implicated with macrophage polarization toward the inflammatory M1-phenotype, nonetheless, changes in the adipose expression of IRF5 in T2D and relationship of these changes with other markers of adipose inflammation remain unclear. Therefore, we determined the IRF5 gene expression in subcutaneous adipose tissue samples from 46 T2D patients including 35 obese (Body Mass Index/BMI 33.83 +/- 0.42kg/m2) and 11 lean/overweight individuals (BMI 27.55 +/- 0.46kg/m2) using real-time qRT-PCR. IRF5 protein expression was assessed using immunohistochemistry and confocal microscopy. Fasting plasma glucose, insulin, HbA1c, C-reactive protein, cholesterol, low- and high-density lipoproteins (LDL/HDL), and triglycerides were measured using commercial kits. IRF5 gene expression was compared with that of signature inflammatory markers and several clinico-metabolic indicators. The data (mean +/- SEM) show the enhanced adipose IRF5 gene (p = 0.03) and protein (p = 0.05) expression in obese compared to lean/overweight diabetic patients. Adipose IRF5 transcripts in diabetic obese individuals associated positively with those of TNF-alpha, IL-18, IL-23A, CXCL8, CCL2, CCL7, CCR1/5, CD11c, CD68, CD86, TLR4/7/10, Dectin-1, FGL-2, MyD88, NF-kappaB, IRF3, and AML1 (p < 0.05). In diabetic lean/overweight subjects, IRF5 expression associated with BMI, body fat %age, glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR, C-reactive protein (CRP), IL-5, and IL-1RL1 expression; while in all T2D patients, IRF5 expression correlated with that of IRF4, TLR2/8, and CD163. In conclusion, upregulated adipose tissue IRF5 expression in diabetic obese patients concurs with the inflammatory signatures and it may represent a potential marker for metabolic inflammation in obesity/T2D.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IRF5 protein, human). 0 (Interferon Regulatory Factors).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fcells9030730
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sindhu&issn=2073-4409&title=Cells&atitle=Enhanced+Adipose+Expression+of+Interferon+Regulatory+Factor+%28IRF%29-5+Associates+with+the+Signatures+of+Metabolic+Inflammation+in+Diabetic+Obese+Patients.&volume=9&issue=3&spage=&epage=&date=2020&doi=10.3390%2Fcells9030730&pmid=32188105&sid=OVID:medline
+
+<1408>
+Unique Identifier
+ 32188008
+Title
+ Adiponectin and Cognitive Decline. [Review]
+Source
+ International Journal of Molecular Sciences. 21(6), 2020 Mar 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rizzo MR; Fasano R; Paolisso G
+Authors Full Name
+ Rizzo, Maria Rosaria; Fasano, Renata; Paolisso, Giuseppe.
+Institution
+ Rizzo, Maria Rosaria. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy.
+ Fasano, Renata. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy.
+ Paolisso, Giuseppe. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy.
+MeSH Subject Headings
+ AMP-Activated Protein Kinases/me [Metabolism]
+ Adiponectin/bl [Blood]
+ *Adiponectin/me [Metabolism]
+ *Adiponectin/pd [Pharmacology]
+ Adipose Tissue/me [Metabolism]
+ Biomarkers
+ Brain/de [Drug Effects]
+ *Central Nervous System/de [Drug Effects]
+ *Cognitive Dysfunction/me [Metabolism]
+ *Dementia/me [Metabolism]
+ Estrogens/ae [Adverse Effects]
+ Female
+ Humans
+ Inflammation
+ Insulin
+ Insulin Resistance/ph [Physiology]
+ Male
+ Memory/de [Drug Effects]
+ Menopause/ph [Physiology]
+ Obesity
+ PPAR alpha
+ Receptors, Adiponectin/me [Metabolism]
+ Risk Factors
+ Signal Transduction
+ Speech Disorders
+Keyword Heading
+ MCI
+ adiponectin
+ cognitive function
+ dementia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adiponectin (ADPN) is a plasma protein secreted by adipose tissue showing pleiotropic effects with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Initially, it was thought that the main role was only the metabolism control. Later, ADPN receptors were also found in the central nervous system (CNS). In fact, the receptors AdipoR1 and AdipoR2 are expressed in various areas of the brain, including the hypothalamus, hippocampus, and cortex. While AdipoR1 regulates insulin sensitivity through the activation of the AMP-activated protein kinase (AMPK) pathway, AdipoR2 stimulates the neural plasticity through the activation of the peroxisome proliferator-activated receptor alpha (PPARalpha) pathway that inhibits inflammation and oxidative stress. Overall, based on its central and peripheral actions, ADPN appears to have neuroprotective effects by reducing inflammatory markers, such as C-reactive protein (PCR), interleukin 6 (IL6), and Tumor Necrosis Factor a (TNFa). Conversely, high levels of inflammatory cascade factors appear to inhibit the production of ADPN, suggesting bidirectional modulation. In addition, ADPN appears to have insulin-sensitizing action. It is known that a reduction in insulin signaling is associated with cognitive impairment. Based on this, it is of great interest to investigate the mechanism of restoration of the insulin signal in the brain as an action of ADPN, because it is useful for testing a possible pharmacological treatment for the improvement of cognitive decline. Anyway, if ADPN regulates neuronal functioning and cognitive performances by the glycemic metabolic system remains poorly explored. Moreover, although the mechanism is still unclear, women compared to men have a doubled risk of developing cognitive decline. Several studies have also supported that during the menopausal transition, the estrogen reduction can adversely affect the brain, in particular, verbal memory and verbal fluency. During the postmenopausal period, in obese and insulin-resistant individuals, ADPN serum levels are significantly reduced. Our recent study has evaluated the relationship between plasma ADPN levels and cognitive performances in menopausal women. Thus, the aim of this review is to summarize both the mechanisms and the effects of ADPN in the central nervous system and the relationship between plasma ADPN levels and cognitive performances, also in menopausal women.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (ADIPOR1 protein, human). 0 (ADIPOR2 protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Estrogens). 0 (Insulin). 0 (PPAR alpha). 0 (Receptors, Adiponectin). EC 2-7-11-31 (AMP-Activated Protein Kinases).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijms21062010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rizzo&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Adiponectin+and+Cognitive+Decline.&volume=21&issue=6&spage=2010&epage=&date=2020&doi=10.3390%2Fijms21062010&pmid=32188008&sid=OVID:medline
+
+<1409>
+Unique Identifier
+ 32184757
+Title
+ Characteristics of Serum Thyroid Hormones in Different Metabolic Phenotypes of Obesity.
+Source
+ Frontiers in Endocrinology. 11:68, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nie X; Ma X; Xu Y; Shen Y; Wang Y; Bao Y
+Authors Full Name
+ Nie, Xiaomin; Ma, Xiaojing; Xu, Yiting; Shen, Yun; Wang, Yufei; Bao, Yuqian.
+Institution
+ Nie, Xiaomin. Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Ma, Xiaojing. Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Xu, Yiting. Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Shen, Yun. Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Wang, Yufei. Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Bao, Yuqian. Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ China/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/cl [Classification]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Phenotype
+ Prognosis
+ Risk Factors
+ *Thyroid Hormones/bl [Blood]
+Keyword Heading
+ fat percentage
+ free thyroxine
+ free triiodothyronine
+ metabolically healthy obese
+ metabolically unhealthy obese
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aim: Metabolically healthy obese (MHO) individuals have attracted broad attention. We aimed to investigate the characteristics of serum thyroid hormones in different metabolic phenotypes of obesity. Methods: The study included 1,023 community-based euthyroid subjects (age range: 27-81 years), of whom 586 were women. Fat% was detected by a bioelectrical impedance analyzer. Two definitions of obesity were applied as follows: (1) fat% >= 25% for men and >= 30% for women; (2) body mass index (BMI) >= 25 kg/m2. According to the diagnostic criteria for metabolic syndrome by the Chinese Diabetes Society, metabolically unhealthy was defined as two or more components of metabolic syndrome, excluding waist circumference. Serum-free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) levels were measured by electrochemiluminescence immunoassay. Results: The proportions of obesity defined by fat% and BMI were 41.3 and 27.1%, respectively. The proportion of metabolically unhealthy was 41.6%. After adjusting for age and gender, regardless of the definitions based on fat% or BMI, FT3 was positively related to both the MHO and the metabolically unhealthy obese (MUO) phenotypes [MHO: odds ratio (OR)s = 1.676 based on fat% and 2.055 based on BMI; MUO: ORs = 1.818 based on fat% and 1.526 based on BMI; all P < 0.05]; FT4 was negatively related to the MUO phenotype (ORs = 0.870 based on fat% and 0.849 based on BMI, all P < 0.05); FT3/FT4 was also positively related to both the MHO and the MUO phenotypes (MHO: ORs = 1.678 based on fat% and 2.825 based on BMI; MUO: ORs = 2.866 based on fat% and 2.883 based on BMI; all P < 0.05); and TSH was positively related to the metabolically unhealthy non-obese phenotype (ORs = 1.329 based on fat% and 1.321 based on BMI, all P < 0.01). Conclusions: In euthyroid population, both the MHO and the MUO phenotypes were characterized by increased FT3 and FT3/FT4 levels. Copyright © 2020 Nie, Ma, Xu, Shen, Wang and Bao.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Thyroid Hormones).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3389%2ffendo.2020.00068
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nie&issn=1664-2392&title=Frontiers+in+Endocrinology&atitle=Characteristics+of+Serum+Thyroid+Hormones+in+Different+Metabolic+Phenotypes+of+Obesity.&volume=11&issue=&spage=68&epage=&date=2020&doi=10.3389%2Ffendo.2020.00068&pmid=32184757&sid=OVID:medline
+
+<1410>
+Unique Identifier
+ 32182790
+Title
+ circRNAs Signature as Potential Diagnostic and Prognostic Biomarker for Diabetes Mellitus and Related Cardiovascular Complications. [Review]
+Source
+ Cells. 9(3), 2020 03 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zaiou M
+Author NameID
+ Zaiou, Mohamed; ORCID: https://orcid.org/0000-0002-4113-4350
+Authors Full Name
+ Zaiou, Mohamed.
+Institution
+ Zaiou, Mohamed. School of Pharmacy, Institut Jean-Lamour, The University of Lorraine, 7 Avenue de la Foret de Haye, CEDEX BP 90170, 54500 Vandoeuvre les Nancy, France.
+MeSH Subject Headings
+ *Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ Cardiovascular Diseases/co [Complications]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ge [Genetics]
+ Diabetes Mellitus/ge [Genetics]
+ Humans
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/ge [Genetics]
+ *RNA, Circular/me [Metabolism]
+ *RNA, Untranslated/me [Metabolism]
+Keyword Heading
+ biomarker
+ cardiovascular diseases (CVD)
+ circular RNAs (circRNAs)
+ diabetes mellitus
+ epigenetics
+ microRNAs (miRNAs)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts mostly generated from precursor-mRNA by a non-canonical event called back-splicing. They are highly stable, evolutionarily conserved, and widely distributed in eukaryotes. Some circRNAs are believed to fulfill a variety of functions inside the cell mainly by acting as microRNAs (miRNAs) or RNA-binding proteins (RBPs) sponges. Furthermore, mounting evidence suggests that the misregulation of circRNAs is among the first alterations in various metabolic disorders including obesity, hypertension, and cardiovascular diseases. More recent research has revealed that circRNAs also play a substantial role in the pathogenesis of diabetes mellitus (DM) and related vascular complications. These findings have added a new layer of complexity to our understanding of DM and underscored the need to reexamine the molecular pathways that lead to this disorder in the context of epigenetics and circRNA regulatory mechanisms. Here, I review current knowledge about circRNAs dysregulation in diabetes and describe their potential role as innovative biomarkers to predict diabetes-related cardiovascular (CV) events. Finally, I discuss some of the actual limitations to the promise of these RNA transcripts as emerging therapeutics and provide recommendations for future research on circRNA-based medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Circular). 0 (RNA, Untranslated).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fcells9030659
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zaiou&issn=2073-4409&title=Cells&atitle=circRNAs+Signature+as+Potential+Diagnostic+and+Prognostic+Biomarker+for+Diabetes+Mellitus+and+Related+Cardiovascular+Complications.&volume=9&issue=3&spage=&epage=&date=2020&doi=10.3390%2Fcells9030659&pmid=32182790&sid=OVID:medline
+
+<1411>
+Unique Identifier
+ 32180061
+Title
+ Environmental factors, serum biomarkers and risk of atrial fibrillation: an exposure-wide umbrella review of meta-analyses.
+Source
+ European Journal of Epidemiology. 35(3):223-239, 2020 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Belbasis L; Mavrogiannis MC; Emfietzoglou M; Evangelou E
+Authors Full Name
+ Belbasis, Lazaros; Mavrogiannis, Michail C; Emfietzoglou, Maria; Evangelou, Evangelos.
+Institution
+ Belbasis, Lazaros. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
+ Mavrogiannis, Michail C. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
+ Emfietzoglou, Maria. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
+ Evangelou, Evangelos. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. vangelis@uoi.gr.
+ Evangelou, Evangelos. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. vangelis@uoi.gr.
+MeSH Subject Headings
+ Alcohol Drinking/ae [Adverse Effects]
+ Atrial Fibrillation/bl [Blood]
+ *Atrial Fibrillation/ep [Epidemiology]
+ *Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Environmental Exposure
+ Female
+ Humans
+ Male
+ Meta-Analysis as Topic
+ Obesity/co [Complications]
+ Observational Studies as Topic
+ Risk Factors
+ Smoking/ae [Adverse Effects]
+Keyword Heading
+ Atrial fibrillation
+ Bias
+ Epidemiological credibility
+ Meta-analysis
+ Risk factors
+ Umbrella review
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Atrial fibrillation (AF) is the most common cardiac arrhythmia. We designed an umbrella review to systematically assess the epidemiological credibility of the associations of non-genetic factors with risk of AF. We searched PubMed and EMBASE from inception to December 31, 2018 to identify systematic reviews and meta-analyses of observational studies for the association of non-genetic factors with risk of AF. For each meta-analysis, we used the random-effects model, and we estimated the 95% confidence and prediction intervals. We also assessed between-study heterogeneity, small-study effects and excess significance bias. We identified 34 eligible papers that examined 51 associations of 42 unique non-genetic factors with risk of AF. Eighteen associations remained statistically significant at P value < 1 x 10-6. Thirty-one associations presented large or very large between-study heterogeneity. Eight associations presented evidence for small-study effects and 13 associations had evidence for excess significance bias. Ten associations, i.e. corrected QT interval, alcohol consumption (highest vs. lowest category, per 1 drink/day increase), body mass index (> 30 units vs. < 30 units, per 5 units increase), waist circumference, body weight, type 2 diabetes mellitus, and smoking (ever vs. never, per 10 cigarettes/day increase) were supported by convincing or highly suggestive evidence in meta-analyses of prospective cohort studies. Type 2 diabetes mellitus, markers of adiposity, alcohol consumption, smoking, and corrected QT interval constitute credible risk factors of AF. Our proposed grading may guide the design of future studies, including Mendelian randomization studies, to assess whether these associations are causal.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs10654-020-00618-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Belbasis&issn=0393-2990&title=European+Journal+of+Epidemiology&atitle=Environmental+factors%2C+serum+biomarkers+and+risk+of+atrial+fibrillation%3A+an+exposure-wide+umbrella+review+of+meta-analyses.&volume=35&issue=3&spage=223&epage=239&date=2020&doi=10.1007%2Fs10654-020-00618-3&pmid=32180061&sid=OVID:medline
+
+<1412>
+Unique Identifier
+ 32179559
+Title
+ Has working-age morbidity been declining? Changes over time in survey measures of general health, chronic diseases, symptoms and biomarkers in England 1994-2014.
+Source
+ BMJ Open. 10(3):e032378, 2020 03 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Geiger BB
+Author NameID
+ Geiger, Ben Baumberg; ORCID: https://orcid.org/0000-0003-0341-3532
+Authors Full Name
+ Geiger, Ben Baumberg.
+Institution
+ Geiger, Ben Baumberg. School of Social Policy, Sociology and Social Research (SSPSSR), University of Kent, Canterbury, UK b.b.geiger@kent.ac.uk.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Chronic Disease/ep [Epidemiology]
+ Cross-Sectional Studies
+ Diabetes Mellitus/ep [Epidemiology]
+ England/ep [Epidemiology]
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Morbidity/td [Trends]
+ Obesity/ep [Epidemiology]
+ Population Health
+Keyword Heading
+ England
+ biomarkers
+ cross-sectional studies
+ morbidity
+ population health
+ trends
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: As life expectancy has increased in high-income countries, there has been a global debate about whether additional years of life are free from ill-health/disability. However, little attention has been given to changes over time in morbidity in the working-age population, particularly outside the USA, despite its importance for health monitoring and social policy. This study therefore asks: what are the changes over time in working-age morbidity in England over two decades?
+
+ DESIGN, SETTING AND PARTICIPANTS: We use a high-quality annual cross-sectional survey, the Health Survey for England (HSE) 1994-2014. HSE uses a random sample of the English household population, with a combined sample size of over 140 000 people. We produce a newly harmonised version of HSE that maximises comparability over time, including new non-response weights. While HSE is used for monitoring population health, it has hitherto not used for investigating morbidity as a whole.
+
+ OUTCOME MEASURES: We analyse all 39 measures that are fully comparable over time-including chronic disease diagnoses, symptomatology and a number of biomarkers-adjusting for gender and age.
+
+ RESULTS: We find a mixed picture: we see improving cardiovascular and respiratory health, but deteriorations in obesity, diabetes, some biomarkers and feelings of extreme anxiety/depression, alongside stability in moderate mental ill-health and musculoskeletal-related health. In several domains we also see stable or rising chronic disease diagnoses even where symptomatology has declined. While data limitations make it challenging to combine these measures into a single morbidity index, there is little systematic trend for declining morbidity to be seen in the measures that predict self-reported health most strongly.
+
+ CONCLUSIONS: Despite considerable falls in working-age mortality-and the assumptions of many policy-makers that morbidity will follow mortality - there is no systematic improvement in overall working-age morbidity in England from 1994 to 2014. Copyright © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1136%2fbmjopen-2019-032378
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Geiger&issn=2044-6055&title=BMJ+Open&atitle=Has+working-age+morbidity+been+declining%3F+Changes+over+time+in+survey+measures+of+general+health%2C+chronic+diseases%2C+symptoms+and+biomarkers+in+England+1994-2014.&volume=10&issue=3&spage=e032378&epage=&date=2020&doi=10.1136%2Fbmjopen-2019-032378&pmid=32179559&sid=OVID:medline
+
+<1413>
+Unique Identifier
+ 32160926
+Title
+ Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study.
+Source
+ Journal of Translational Medicine. 18(1):122, 2020 03 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Olsen T; Ovrebo B; Haj-Yasein N; Lee S; Svendsen K; Hjorth M; Bastani NE; Norheim F; Drevon CA; Refsum H; Vinknes KJ
+Authors Full Name
+ Olsen, Thomas; Ovrebo, Bente; Haj-Yasein, Nadia; Lee, Sindre; Svendsen, Karianne; Hjorth, Marit; Bastani, Nasser E; Norheim, Frode; Drevon, Christian A; Refsum, Helga; Vinknes, Kathrine J.
+Institution
+ Olsen, Thomas. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway. thomas.olsen@medisin.uio.no.
+ Ovrebo, Bente. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Haj-Yasein, Nadia. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Lee, Sindre. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Svendsen, Karianne. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Svendsen, Karianne. The Lipid Clinic, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, OUS HF Aker Sykehus, Postboks 4959, Nydalen, 0424, Oslo, Norway.
+ Hjorth, Marit. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Bastani, Nasser E. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Norheim, Frode. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Drevon, Christian A. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Refsum, Helga. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+ Vinknes, Kathrine J. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046, Blindern, 0317, Oslo, Norway.
+MeSH Subject Headings
+ Adipose Tissue
+ Biomarkers
+ *Cysteine
+ Diet
+ Fibroblast Growth Factors
+ Gene Expression
+ Humans
+ *Methionine
+ Obesity/ge [Genetics]
+ Overweight/ge [Genetics]
+ Pilot Projects
+Keyword Heading
+ Adipose tissue
+ Dietary intervention
+ Methionine restriction
+ Plasma biomarkers
+ Translational research
+ mRNA expression
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential in humans, we evaluated the effects of dietary methionine and cysteine restriction on cardiometabolic risk factors, plasma and urinary amino acid profile, serum fibroblast growth factor 21 (FGF21), and subcutaneous adipose tissue gene expression in women with overweight and obesity in a double-blind randomized controlled pilot study.
+
+ METHODS: Twenty women with overweight or obesity were allocated to a diet low (Met/Cys-low, n = 7), medium (Met/Cys-medium, n = 7) or high (Met/Cys-high, n = 6) in methionine and cysteine for 7 days. The diets differed only by methionine and cysteine content. Blood and urine were collected at day 0, 1, 3 and 7 and subcutaneous adipose tissue biopsies were taken at day 0 and 7.
+
+ RESULTS: Plasma methionine and cystathionine and urinary total cysteine decreased, whereas FGF21 increased in the Met/Cys-low vs. Met/Cys-high group. The Met/Cys-low group had increased mRNA expression of lipogenic genes in adipose tissue including DGAT1. When we excluded one participant with high fasting insulin at baseline, the Met/Cys-low group showed increased expression of ACAC, DGAT1, and tendencies for increased expression of FASN and SCD1 compared to the Met/Cys-high group. The participants reported satisfactory compliance and that the diets were moderately easy to follow.
+
+ CONCLUSIONS: Our data suggest that dietary methionine and cysteine restriction may have beneficial effects on circulating biomarkers, including FGF21, and influence subcutaneous adipose tissue gene expression. These results will aid in the design and implementation of future large-scale dietary interventions with methionine and cysteine restriction. Trial registration ClinicalTrials.gov Identifier: NCT03629392, registration date: 14/08/2018 https://clinicaltrials.gov/ct2/show/NCT03629392.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors). AE28F7PNPL (Methionine). K848JZ4886 (Cysteine).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12967-020-02288-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Olsen&issn=1479-5876&title=Journal+of+Translational+Medicine&atitle=Effects+of+dietary+methionine+and+cysteine+restriction+on+plasma+biomarkers%2C+serum+fibroblast+growth+factor+21%2C+and+adipose+tissue+gene+expression+in+women+with+overweight+or+obesity%3A+a+double-blind+randomized+controlled+pilot+study.&volume=18&issue=1&spage=122&epage=&date=2020&doi=10.1186%2Fs12967-020-02288-x&pmid=32160926&sid=OVID:medline
+
+<1414>
+Unique Identifier
+ 32159582
+Title
+ Impact of metabolic and inflammatory changes on glomerular function beyond conventional risk factors in an urban South Africa community with prevalent obesity.
+Source
+ Cardiovascular Journal of Africa. 31(4):91-102, 2020 Mar/Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Norman G; Woodiwiss AJ; Peterson V; Gomes M; Sareli P; Norton GR
+Authors Full Name
+ Norman, Glenda; Woodiwiss, Angela J; Peterson, Vernice; Gomes, Monica; Sareli, Pinhas; Norton, Gavin R.
+Institution
+ Norman, Glenda. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Woodiwiss, Angela J. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Email: angela.woodiwiss@wits.ac.za.
+ Peterson, Vernice. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Gomes, Monica. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Sareli, Pinhas. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+ Norton, Gavin R. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Cross-Sectional Studies
+ Female
+ *Glomerular Filtration Rate
+ Humans
+ Inflammation/di [Diagnosis]
+ *Inflammation/ep [Epidemiology]
+ Inflammation/pp [Physiopathology]
+ Inflammation Mediators/bl [Blood]
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ *Kidney Glomerulus/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Prevalence
+ Prognosis
+ Renal Insufficiency, Chronic/di [Diagnosis]
+ *Renal Insufficiency, Chronic/ep [Epidemiology]
+ Renal Insufficiency, Chronic/pp [Physiopathology]
+ Resistin/bl [Blood]
+ Risk Assessment
+ Risk Factors
+ South Africa/ep [Epidemiology]
+Keyword Heading
+ chronic kidney disease
+ insulin resistance
+ resistin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To determine the extent to which metabolic and inflammatory changes are associated with renal damage beyond conventional risk factors in a community sample with a high prevalence of obesity in urban South Africa.
+
+ METHODS: This was a cross-sectional, community-based study in 1 010 (n = 872 without diabetes mellitus, DM) randomly selected participants over 16 years of age in an urban, developing community (Soweto, Johannesburg) with a high prevalence of obesity (41.8%). We assessed estimated glomerular filtration rate (eGFR), conventional risk factors including adiposity indices, and metabolic changes and plasma resistin concentrations (ELISA) and the homeostasis model of insulin resistance (HOMA-IR). Relationships independent of haemodynamic loads were confirmed using ambulatory blood pressure and central arterial haemodynamics.
+
+ RESULTS: In multivariate regression models conducted in those without DM, HOMA-IR (standardised beta-coefficient = -0.13 +/- 0.03, p < 0.0001) and plasma resistin concentrations (beta-coefficient = -0.10 +/- 0.02, p < 0.0001) were second only to age, and at least as strong as systolic blood pressure (beta -coefficient = -0.04 +/- 0.03, p = 0.19) in the impact on eGFR, while alternative conventional risk factors including adiposity indices and the metabolic syndrome features contributed little to eGFR. Similar results were obtained in relationships with chronic kidney disease (CKD) and in the whole group including those with DM. Adjustments for ambulatory blood pressure or central arterial loads did not influence these relationships.
+
+ CONCLUSIONS: The impact on glomerular function of insulin resistance and inflammatory changes is well beyond modifiable conventional risk factors, including the metabolic syndrome. Targeting conventional risk factors alone is likely to result in a marked residual risk of renal damage produced by insulin resistance and inflammation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Inflammation Mediators). 0 (Insulin). 0 (RETN protein, human). 0 (Resistin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.5830%2fCVJA-2019-057
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Norman&issn=1015-9657&title=Cardiovascular+Journal+of+Africa&atitle=Impact+of+metabolic+and+inflammatory+changes+on+glomerular+function+beyond+conventional+risk+factors+in+an+urban+South+Africa+community+with+prevalent+obesity.&volume=31&issue=4&spage=91&epage=102&date=2020&doi=10.5830%2FCVJA-2019-057&pmid=32159582&sid=OVID:medline
+
+<1415>
+Unique Identifier
+ 32159445
+Title
+ The rs822396 Polymorphism of the ADIPOQ Gene Is Associated with Anthropometric, Clinical, and Biochemical Alterations Related to the Metabolic Syndrome in the Mexican Population.
+Source
+ Metabolic Syndrome & Related Disorders. 18(5):243-250, 2020 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rubio-Chavez LA; Rosales-Gomez RC; Rubio-Chavez KL; Ramos-Nunez JL; Garcia-Cobian TA; Camargo-Hernandez G; Sanchez-Corona J; Gutierrez-Rubio SA
+Authors Full Name
+ Rubio-Chavez, Lidia Ariadna; Rosales-Gomez, Roberto Carlos; Rubio-Chavez, Keren-Hapuc Lilian; Ramos-Nunez, Julia Leonila; Garcia-Cobian, Teresa Arcelia; Camargo-Hernandez, Gabriela; Sanchez-Corona, Jose; Gutierrez-Rubio, Susan Andrea.
+Institution
+ Rubio-Chavez, Lidia Ariadna. Laboratorio del Instituto de Terapeutica Experimental y Clinica, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
+ Rosales-Gomez, Roberto Carlos. Departamento de Ciencias Biomedicas, Centro Universitario de Tonala, Universidad de Guadalajara, Tonala, Mexico.
+ Rubio-Chavez, Keren-Hapuc Lilian. Laboratorio del Instituto de Terapeutica Experimental y Clinica, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
+ Ramos-Nunez, Julia Leonila. Laboratorio del Instituto de Terapeutica Experimental y Clinica, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
+ Garcia-Cobian, Teresa Arcelia. Laboratorio del Instituto de Terapeutica Experimental y Clinica, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
+ Camargo-Hernandez, Gabriela. Departamento de Ciencias de la Salud, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlan, Mexico.
+ Sanchez-Corona, Jose. Division de Medicina Molecular, Centro de Investigacion Biomedica del Occidente, IMSS Instituto Mexicano del Seguro Social, Guadalajara, Mexico.
+ Gutierrez-Rubio, Susan Andrea. Laboratorio del Instituto de Terapeutica Experimental y Clinica, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
+MeSH Subject Headings
+ *Adiponectin/ge [Genetics]
+ Adiposity
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ Blood Pressure
+ Cross-Sectional Studies
+ Female
+ Gene Frequency
+ Genetic Predisposition to Disease
+ Humans
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome/ge [Genetics]
+ Metabolic Syndrome/pp [Physiopathology]
+ Mexico/ep [Epidemiology]
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ Phenotype
+ *Polymorphism, Single Nucleotide
+ Risk Assessment
+ Risk Factors
+ Young Adult
+Keyword Heading
+ ADIPOQ
+ adiponectin
+ metabolic syndrome
+ polymorphism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Adiponectin, encoded by the ADIPOQ gene, is produced mainly by adipose tissue, and meaning as a metabolic and immunological regulator. The polymorphism rs822396 in ADIPOQ gene was previously associated with diabetes mellitus type 2, hypertension, and metabolic syndrome components in Caucasian and Asiatic populations. The aim was to evaluate the association of the rs822396 polymorphism of the ADIPOQ gene with anthropometric, clinical, and biochemical alterations related to the metabolic syndrome in the Mexican population. Materials and Methods: Measurements, as well as peripheral blood for DNA extraction, were obtained from 434 participants from Mexico. The rs822396 polymorphism genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Statistical analysis was made with IBM-SPSSv20. Results: The rs822396G allele frequency was 22.1% in the Mexican population analyzed. In this study were detected differences according to G allele or GG genotype with the highest means, including body mass index (BMI), waist circumference (WC), body fat percentage, visceral fat, systolic arterial tension, glucose levels, triglyceride levels, total cholesterol (TC) levels, very low-density lipoprotein, alanine aminotransferase, and aspartate aminotransferase and with triglycerides/glucose index. Significant differences were found with increased risk in the dominant model (AG/GG) of anthropometric, clinical, and biochemical alterations with regard to metabolic syndrome as the BMI [odds ratio (OR) = 2.19], WC (OR = 2.00), waist/hip index (OR = 1.65), body fat percentage (OR = 2.76), visceral fat (OR = 1.84), glucose levels (OR = 1.95), triglyceride levels (OR = 2.75), TC levels (OR = 1.63), high-density lipoprotein (OR = 1.86), and insulin resistance surrogated by the Triglyceride/glucose index (OR = 2.64). Conclusion: The rs822396 polymorphism of the ADIPOQ gene seems to be a risk factor for obesity and metabolic alterations with regard to the metabolic syndrome in the Mexican population.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1089%2fmet.2019.0045
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rubio-Chavez&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=The+rs822396+Polymorphism+of+the+ADIPOQ+Gene+Is+Associated+with+Anthropometric%2C+Clinical%2C+and+Biochemical+Alterations+Related+to+the+Metabolic+Syndrome+in+the+Mexican+Population.&volume=18&issue=5&spage=243&epage=250&date=2020&doi=10.1089%2Fmet.2019.0045&pmid=32159445&sid=OVID:medline
+
+<1416>
+Unique Identifier
+ 32157924
+Title
+ Galectin-3 is a potential biomarker to insulin resistance and obesity in women with polycystic ovary syndrome.
+Source
+ Gynecological Endocrinology. 36(9):760-763, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alves MT; de Souza IDP; Ferreira CN; Candido AL; Bizzi MF; Oliveira FR; Reis FM; Gomes KB
+Author NameID
+ Gomes, Karina B; ORCID: http://orcid.org/0000-0002-6870-2063
+Authors Full Name
+ Alves, Michelle T; de Souza, Isabella D P; Ferreira, Claudia N; Candido, Ana Lucia; Bizzi, Mariana F; Oliveira, Flavia R; Reis, Fernando M; Gomes, Karina B.
+Institution
+ Alves, Michelle T. Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ de Souza, Isabella D P. Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Ferreira, Claudia N. Colegio Tecnico, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Candido, Ana Lucia. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Bizzi, Mariana F. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Oliveira, Flavia R. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Oliveira, Flavia R. Maternidade Odete Valadares - Fundacao Hospitalar do Estado de Minas Gerais, Belo Horizonte, Brazil.
+ Reis, Fernando M. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+ Gomes, Karina B. Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Proteins
+ Body Mass Index
+ Case-Control Studies
+ Female
+ *Galectins/bl [Blood]
+ Glucose Tolerance Test
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/co [Complications]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+Keyword Heading
+ Polycystic ovary syndrome
+ galectin-3
+ glucose
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder that affects women in reproductive age. This study aimed to evaluate Gal-3 levels and its role on metabolic parameters in women with PCOS. Gal-3 was measured in 44 PCOS and 25 women recruited as control group for the case-control study. Gal-3 levels were similar between PCOS and control groups (p > 0.05), but showed a positive correlation with glucose levels in the oral glucose tolerance test (OGTT) (r = 0.403, p = 0.037), body mass index (BMI) (r = 0.469, p = 0.027), insulin levels (r = 0.453, p = 0.030) and HOMA-IR (r = 0.738, p = 0.037) in PCOS group. The data suggest that Gal-3 plays a role in the pathophysiology of the insulin resistance and obesity in PCOS group.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Proteins). 0 (Galectins). 0 (LGALS3 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1080%2f09513590.2020.1739267
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alves&issn=0951-3590&title=Gynecological+Endocrinology&atitle=Galectin-3+is+a+potential+biomarker+to+insulin+resistance+and+obesity+in+women+with+polycystic+ovary+syndrome.&volume=36&issue=9&spage=760&epage=763&date=2020&doi=10.1080%2F09513590.2020.1739267&pmid=32157924&sid=OVID:medline
+
+<1417>
+Unique Identifier
+ 32151028
+Title
+ Physalis peruviana L. Pulp Prevents Liver Inflammation and Insulin Resistance in Skeletal Muscles of Diet-Induced Obese Mice.
+Source
+ Nutrients. 12(3), 2020 Mar 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fuente FP; Nocetti D; Sacristan C; Ruiz P; Guerrero J; Jorquera G; Uribe E; Bucarey JL; Espinosa A; Puente L
+Author NameID
+ Jorquera, Gonzalo; ORCID: https://orcid.org/0000-0001-7890-7321
+Authors Full Name
+ Fuente, Francisco Pino-de la; Nocetti, Diego; Sacristan, Camila; Ruiz, Paulina; Guerrero, Julia; Jorquera, Gonzalo; Uribe, Ernesto; Bucarey, Jose Luis; Espinosa, Alejandra; Puente, Luis.
+Institution
+ Fuente, Francisco Pino-de la. Departamento de Tecnologia Medica, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
+ Nocetti, Diego. Programa de Doctorado en Ciencias Medicas, Universidad de La Frontera, Temuco 4811230, Chile.
+ Nocetti, Diego. Departamento de Tecnologia Medica, Universidad de Tarapaca, Arica 1010069, Chile.
+ Sacristan, Camila. Departamento de Tecnologia Medica, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
+ Ruiz, Paulina. Departamento de Tecnologia Medica, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
+ Guerrero, Julia. Programa de Fisiologia, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
+ Guerrero, Julia. Departamento de Medicina Interna, Hospital Clinico-Universidad de Chile, Santiago 8380456, Chile.
+ Jorquera, Gonzalo. Centro de Neurobiologia y Fisiopatologia Integrativa, Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2391415, Chile.
+ Uribe, Ernesto. Departamento de Tecnologia Medica, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
+ Bucarey, Jose Luis. Escuela de Medicina, Campus San Felipe, Universidad de Valparaiso, San Felipe 2340000, Chile.
+ Espinosa, Alejandra. Departamento de Tecnologia Medica, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
+ Espinosa, Alejandra. Escuela de Medicina, Campus San Felipe, Universidad de Valparaiso, San Felipe 2340000, Chile.
+ Puente, Luis. Departamento de Ciencias de los Alimentos, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago 8380494, Chile.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Body Weight
+ Diet, High-Fat
+ Disease Models, Animal
+ Fruit/ch [Chemistry]
+ Glucose Tolerance Test
+ *Hepatitis, Animal/et [Etiology]
+ *Hepatitis, Animal/me [Metabolism]
+ Hepatitis, Animal/pa [Pathology]
+ Hepatitis, Animal/pc [Prevention & Control]
+ Inflammation Mediators/me [Metabolism]
+ Insulin/me [Metabolism]
+ *Insulin Resistance
+ Lipid Peroxidation/de [Drug Effects]
+ Male
+ Mice
+ *Muscle, Skeletal/de [Drug Effects]
+ *Muscle, Skeletal/me [Metabolism]
+ *Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Physalis/ch [Chemistry]
+ Plant Extracts/ch [Chemistry]
+ *Plant Extracts/pd [Pharmacology]
+ Protective Agents/ch [Chemistry]
+ Protective Agents/pd [Pharmacology]
+Keyword Heading
+ Cape gooseberry
+ insulin resistance
+ lipid droplets
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ A chronic high-fat diet (HFD) produces obesity, leading to pathological consequences in the liver and skeletal muscle. The fat in the liver leads to accumulation of a large number of intrahepatic lipid droplets (LD), which are susceptible to oxidation. Obesity also affects skeletal muscle, increasing LD and producing insulin signaling impairment. Physalis peruviana L. (PP) (Solanaceae) is rich in peruvioses and has high antioxidant activity. We assessed the ability of PP to enhance insulin-dependent glucose uptake in skeletal muscle and the capacity to prevent both inflammation and lipoperoxidation in the liver of diet-induced obese mice. Male C57BL/6J mice were divided into groups and fed for eight weeks: control diet (C; 10% fat, 20% protein, 70% carbohydrates); C + PP (300 mg/kg/day); HFD (60% fat, 20% protein, 20% carbohydrates); and HFD + PP. Results suggest that PP reduces the intracellular lipoperoxidation level and the size of LD in both isolated hepatocytes and skeletal muscle fibers. PP also promotes insulin-dependent skeletal muscle glucose uptake. In conclusion, daily consumption of 300 mg/kg of fresh pulp of PP could be a novel strategy to prevent the hepatic lipoperoxidation and insulin resistance induced by obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Insulin). 0 (Plant Extracts). 0 (Protective Agents).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12030700
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fuente&issn=2072-6643&title=Nutrients&atitle=Physalis+peruviana+L.+Pulp+Prevents+Liver+Inflammation+and+Insulin+Resistance+in+Skeletal+Muscles+of+Diet-Induced+Obese+Mice.&volume=12&issue=3&spage=&epage=&date=2020&doi=10.3390%2Fnu12030700&pmid=32151028&sid=OVID:medline
+
+<1418>
+Unique Identifier
+ 32142970
+Title
+ Daily watermelon consumption decreases plasma sVCAM-1 levels in overweight and obese postmenopausal women.
+Source
+ Nutrition Research. 76:9-19, 2020 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shanely RA; Zwetsloot JJ; Jurrissen TJ; Hannan LC; Zwetsloot KA; Needle AR; Bishop AE; Wu G; Perkins-Veazie P
+Authors Full Name
+ Shanely, R Andrew; Zwetsloot, Jennifer J; Jurrissen, Thomas J; Hannan, Lauren C; Zwetsloot, Kevin A; Needle, Alan R; Bishop, Anna E; Wu, Guoyao; Perkins-Veazie, Penelope.
+Institution
+ Shanely, R Andrew. Appalachian State University, Department of Health and Exercise Science, 1179 State Farm Rd, Boone, NC 28608. Electronic address: shanelyra@appstate.edu.
+ Zwetsloot, Jennifer J. Appalachian State University, Department of Health and Exercise Science, 1179 State Farm Rd, Boone, NC 28608. Electronic address: zwetslootjj@appstate.edu.
+ Jurrissen, Thomas J. Appalachian State University, Department of Health and Exercise Science, 1179 State Farm Rd, Boone, NC 28608. Electronic address: tjjmy9@mail.missouri.edu.
+ Hannan, Lauren C. Appalachian State University, Department of Health and Exercise Science, 1179 State Farm Rd, Boone, NC 28608. Electronic address: lauren.hannan@performance-therapy.com.
+ Zwetsloot, Kevin A. Appalachian State University, Department of Health and Exercise Science, 1179 State Farm Rd, Boone, NC 28608. Electronic address: zwetslootka@appstate.edu.
+ Needle, Alan R. Appalachian State University, Department of Health and Exercise Science, 1179 State Farm Rd, Boone, NC 28608. Electronic address: needlear@appstate.edu.
+ Bishop, Anna E. Appalachian State University, Department of Health and Exercise Science, 1179 State Farm Rd, Boone, NC 28608. Electronic address: abishop@highpoint.edu.
+ Wu, Guoyao. Texas A&M University, Department of Animal Science, 2471 TAMU, College Station, TX, 77843. Electronic address: g-wu@exchange.tamu.edu.
+ Perkins-Veazie, Penelope. North Carolina State University, Department of Horticultural Science, Plants for Human Health Institute, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC 28081. Electronic address: penelope_perkins@ncsu.edu.
+MeSH Subject Headings
+ Arginine/bl [Blood]
+ Arginine/tu [Therapeutic Use]
+ *Atherosclerosis/bl [Blood]
+ Atherosclerosis/dh [Diet Therapy]
+ Atherosclerosis/pc [Prevention & Control]
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Composition
+ Citrulline/tu [Therapeutic Use]
+ *Citrullus/ch [Chemistry]
+ *Diet
+ Female
+ *Fruit/ch [Chemistry]
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Lycopene/bl [Blood]
+ Lycopene/tu [Therapeutic Use]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Overweight/bl [Blood]
+ Plant Extracts/bl [Blood]
+ Plant Extracts/tu [Therapeutic Use]
+ *Postmenopause
+ *Vascular Cell Adhesion Molecule-1/bl [Blood]
+Keyword Heading
+ Cardiovascular risk
+ HOMA-IR
+ Insulin
+ Randomized, parallel assignment design
+ l-Arginine
+ l-Citrulline
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Postmenopausal status is associated with an increase in total and abdominal body fat as well as increased incidence of insulin resistance and cardiovascular disease. The purpose of this study was to determine if watermelon supplementation affects select systemic markers of atherosclerosis and measures of insulin resistance in overweight and obese postmenopausal women. We hypothesized that overweight and obese postmenopausal women consuming 100% watermelon puree daily for 6 weeks would have improved levels of select systemic markers connected with cardiovascular disease without changing markers of insulin resistance. To test this hypothesis, overweight and obese postmenopausal women were recruited to participate in this study. Participants were randomly assigned to either the control group (no intervention) or the watermelon puree group (WM) for 6 weeks. Plasma concentration of markers connected with atherosclerosis and glycemic control were measured pre- and poststudy. A significant 6% decrease in soluble vascular cell adhesion molecule-1 occurred pre- to poststudy in WM, P=.003. The pattern of change in fasting blood glucose (P=.633), insulin (P=.158), and homeostatic model assessment-estimated insulin resistance (P=.174) did not differ between groups. Pre- to poststudy increases were measured in the fasting plasma concentration of l-arginine (8%, P=.005), cis-lycopene (32%, P=.003), and trans-lycopene (42%, P=.003) in WM. We conclude that 6 weeks of watermelon supplementation improved soluble vascular cell adhesion molecule-1 levels, a marker connected to atherogenesis, independent of changes in body composition or glycemic control. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Plant Extracts). 0 (Vascular Cell Adhesion Molecule-1). 29VT07BGDA (Citrulline). 94ZLA3W45F (Arginine). SB0N2N0WV6 (Lycopene).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.nutres.2020.02.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shanely&issn=0271-5317&title=Nutrition+Research&atitle=Daily+watermelon+consumption+decreases+plasma+sVCAM-1+levels+in+overweight+and+obese+postmenopausal+women.&volume=76&issue=&spage=9&epage=19&date=2020&doi=10.1016%2Fj.nutres.2020.02.005&pmid=32142970&sid=OVID:medline
+
+<1419>
+Unique Identifier
+ 32138805
+Title
+ Biomarkers of appetite: is there a potential role for metabolomics?. [Review]
+Source
+ Nutrition Research Reviews. 33(2):271-286, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Horner K; Hopkins M; Finlayson G; Gibbons C; Brennan L
+Author NameID
+ Brennan, Lorraine; ORCID: https://orcid.org/0000-0002-7711-7499
+Authors Full Name
+ Horner, Katy; Hopkins, Mark; Finlayson, Graham; Gibbons, Catherine; Brennan, Lorraine.
+Institution
+ Horner, Katy. UCD School of Public Health, Physiotherapy and Sport Science, Institute of Food and Health and Institute of Sport and Health, UCD, Belfield, Dublin 4, Republic of Ireland.
+ Hopkins, Mark. School of Food Science and Nutrition, Faculty of Environment, University of Leeds, Leeds, UK.
+ Finlayson, Graham. School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
+ Gibbons, Catherine. School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
+ Brennan, Lorraine. UCD School of Agriculture and Food Science, Institute of Food and Health, UCD, Belfield, Dublin 4, Republic of Ireland.
+ Brennan, Lorraine. UCD Conway Institute of Biomolecular and Biomedical Research, UCD, Belfield, Dublin 4, Republic of Ireland.
+MeSH Subject Headings
+ Appetite
+ *Appetite Regulation
+ Biomarkers/me [Metabolism]
+ *Eating
+ *Energy Intake
+ *Feeding Behavior
+ Humans
+ *Metabolomics/mt [Methods]
+ *Nutrients/me [Metabolism]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Obesity
+Keyword Heading
+ Amino acids
+ Appetite
+ Glucose
+ Lipids
+ Metabolites
+ Satiety
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Knowing the biological signals associated with appetite control is crucial for understanding the regulation of food intake. Biomarkers of appetite have been defined as physiological measures that relate to subjective appetite ratings, measured food intake, or both. Several metabolites including amino acids, lipids and glucose were proposed as key molecules associated with appetite control over 60 years ago, and along with bile acids are all among possible appetite biomarker candidates. Additional metabolites that have been associated with appetite include endocannabinoids, lactate, cortisol and beta-hydroxybutyrate. However, although appetite is a complex integrative process, studies often investigated a limited number of markers in isolation. Metabolomics involves the study of small molecules or metabolites present in biological samples such as urine or blood, and may present a powerful approach to further the understanding of appetite control. Using multiple analytical techniques allows the characterisation of molecules, such as carbohydrates, lipids, amino acids, bile acids and fatty acids. Metabolomics has proven successful in identifying markers of consumption of certain foods and biomarkers implicated in several diseases. However, it has been underexploited in appetite control or obesity. The aim of the present narrative review is to: (1) provide an overview of existing metabolites that have been identified in human biofluids and associated with appetite control; and (2) discuss the potential of metabolomics to deepen understanding of appetite control in humans.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1017%2fS0954422420000062
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Horner&issn=0954-4224&title=Nutrition+Research+Reviews&atitle=Biomarkers+of+appetite%3A+is+there+a+potential+role+for+metabolomics%3F.&volume=33&issue=2&spage=271&epage=286&date=2020&doi=10.1017%2FS0954422420000062&pmid=32138805&sid=OVID:medline
+
+<1420>
+Unique Identifier
+ 32134014
+Title
+ Comparison of plasma adipocytokines & C-reactive protein levels in healthy schoolgoing adolescents from private & government-funded schools of Delhi, India.
+Source
+ Indian Journal of Medical Research. 151(1):47-58, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chakraborty S; Prasad G; Marwaha RK; Basu A; Tandon N; Bharadwaj D
+Authors Full Name
+ Chakraborty, Shraddha; Prasad, Gauri; Marwaha, Raman Kumar; Basu, Analabha; Tandon, Nikhil; Bharadwaj, Dwaipayan.
+Institution
+ Chakraborty, Shraddha. Genomics & Molecular Medicine Unit, CSIR-Institute of Genomics & Integrative Biology; Academy of Scientific & Innovative Research, CSIR-Institute of Genomics & Integrative Biology South Campus, New Delhi, India.
+ Prasad, Gauri. Genomics & Molecular Medicine Unit, CSIR-Institute of Genomics & Integrative Biology; Academy of Scientific & Innovative Research, CSIR-Institute of Genomics & Integrative Biology South Campus, New Delhi, India.
+ Marwaha, Raman Kumar. Department of Endocrinology, International Life Sciences Institute, New Delhi, India.
+ Basu, Analabha. Statistical & Computational Genomics, National Institute of Biomedical Genomics, Kalyani, West Bengal, India.
+ Tandon, Nikhil. Department of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
+ Bharadwaj, Dwaipayan. Academy of Scientific & Innovative Research, CSIR-Institute of Genomics & Integrative Biology South Campus; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adolescent
+ *Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Child
+ Feeding Behavior
+ Female
+ Humans
+ India/ep [Epidemiology]
+ *Inflammation/bl [Blood]
+ Leptin/bl [Blood]
+ Life Style
+ Male
+ *Obesity/bl [Blood]
+ *Pediatric Obesity/bl [Blood]
+ Pediatric Obesity/ep [Epidemiology]
+ Pediatric Obesity/pa [Pathology]
+ Resistin/bl [Blood]
+ Risk Factors
+Keyword Heading
+ Adipocytokines
+ CRP
+ Indian adolescents
+ inflammatory markers
+ juvenile health
+ lifestyle changes
+ obesity
+ socio-economic status
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background & objectives: Obesity-mediated chronic inflammatory state is primarily governed by lifestyle and food habits in adolescents and marked by alterations in the level of various inflammatory markers. This cross-sectional study was aimed to compare the inflammatory status of healthy Indian adolescents vis-a-vis their obesity profile. The inflammatory state of urban adolescents attending private and government-funded schools, and the relationship between inflammatory marker levels and anthropometric indices in the study participants from both groups were examined.
+
+ Methods: A total of 4438 study participants (10-17 yr) were chosen from various schools of Delhi, India, and their anthropometric parameters were measured. Plasma adipocytokines (adiponectin, leptin and resistin) of the study participants were measured by enzyme-linked immunosorbent assay, and plasma C-reactive protein (CRP) levels were assayed by a biochemical analyzer. Metabolic syndrome-related risk factors such as waist circumference, hip circumference (HC), fasting glucose, fasting insulin, Homeostatic Model Assessment of Insulin Resistance, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and triglycerides of normal-weight adolescents were also evaluated.
+
+ Results: The level of leptin and CRP increased with increasing adiposity, whereas adiponectin levels were found to be negatively related to obesity. All plasma cytokine levels (adiponectin, leptin and resistin) were significantly elevated in female than male adolescents. Age-based classification revealed a distinct trend of variability in the levels of all the inflammatory markers among adolescents of varying age groups. Significant differences were observed between private and government schoolgoing adolescents in terms of anthropometric and inflammatory parameters, with higher adiposity indices in the former group. The relationship of plasma adipokine and CRP levels with various adiposity indices was found to be distinctly different between private and government schoolgoing students.
+
+ Interpretation & conclusions: Inflammatory markers were significantly elevated in overweight/obese adolescents. The socio-economic condition of urban Indian schoolgoing adolescents reflecting lifestyle transition has profound effects on their adiposity indices and inflammatory states. Longitudinal studies in different regions of the country need to be done to further confirm the findings.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin). 0 (Resistin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.4103%2fijmr.IJMR_1631_18
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chakraborty&issn=0971-5916&title=Indian+Journal+of+Medical+Research&atitle=Comparison+of+plasma+adipocytokines+%26+C-reactive+protein+levels+in+healthy+schoolgoing+adolescents+from+private+%26+government-funded+schools+of+Delhi%2C+India.&volume=151&issue=1&spage=47&epage=58&date=2020&doi=10.4103%2Fijmr.IJMR_1631_18&pmid=32134014&sid=OVID:medline
+
+<1421>
+Unique Identifier
+ 32134010
+Title
+ Obesity subtypes, related biomarkers & heterogeneity. [Review]
+Source
+ Indian Journal of Medical Research. 151(1):11-21, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mayoral LP; Andrade GM; Mayoral EP; Huerta TH; Canseco SP; Rodal Canales FJ; Cabrera-Fuentes HA; Cruz MM; Perez Santiago AD; Alpuche JJ; Zenteno E; Ruiz HM; Cruz RM; Jeronimo JH; Perez-Campos E
+Authors Full Name
+ Mayoral, Laura Perez-Campos; Andrade, Gabriel Mayoral; Mayoral, Eduardo Perez-Campos; Huerta, Teresa Hernandez; Canseco, Socorro Pina; Rodal Canales, Francisco J; Cabrera-Fuentes, Hector Alejandro; Cruz, Margarito Martinez; Perez Santiago, Alma Dolores; Alpuche, Juan Jose; Zenteno, Edgar; Ruiz, Hector Martinez; Cruz, Ruth Martinez; Jeronimo, Julia Hernandez; Perez-Campos, Eduardo.
+Institution
+ Mayoral, Laura Perez-Campos. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Andrade, Gabriel Mayoral. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Mayoral, Eduardo Perez-Campos. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Huerta, Teresa Hernandez. CONACyT-Faculty of Medicine, Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Canseco, Socorro Pina. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Rodal Canales, Francisco J. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Cabrera-Fuentes, Hector Alejandro. Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore; Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany.
+ Cruz, Margarito Martinez. National Technological Institute of Mexico, ITOaxaca, Oaxaca, Mexico.
+ Perez Santiago, Alma Dolores. National Technological Institute of Mexico, ITOaxaca, Oaxaca, Mexico.
+ Alpuche, Juan Jose. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Zenteno, Edgar. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Ruiz, Hector Martinez. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Cruz, Ruth Martinez. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Jeronimo, Julia Hernandez. Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juarez Autonomous University of Oaxaca, Oaxaca, Mexico.
+ Perez-Campos, Eduardo. National Technological Institute of Mexico, ITOaxaca; Clinical Pathology Laboratory 'Dr. Eduardo Perez Ortega' Oaxaca, Mexico.
+MeSH Subject Headings
+ Adult
+ *Biomarkers
+ Genotype
+ Humans
+ Obesity/cl [Classification]
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ Phenotype
+ *Proteins/ge [Genetics]
+Keyword Heading
+ Adipose tissue
+ HOMA
+ biomarkers
+ body fat
+ genome-wide association studies
+ heterogeneity
+ obesity
+ subtypes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a serious medical condition worldwide, which needs new approaches and recognized international consensus in treating diseases leading to morbidity. The aim of this review was to examine heterogeneous links among the various phenotypes of obesity in adults. Proteins and associated genes in each group were analysed to differentiate between biomarkers. A variety of terms for classification and characterization within this pathology are currently in use; however, there is no clear consensus in terminology. The most significant groups reviewed include metabolically healthy obese, metabolically abnormal obese, metabolically abnormal, normal weight and sarcopenic obese. These phenotypes do not define particular genotypes or epigenetic gene regulation, or proteins related to inflammation. There are many other genes linked to obesity, though the value of screening all of those for diagnosis has low predictive results, as there are no significant biomarkers. It is important to establish a consensus in the terminology used and the characteristics attributed to obesity subtypes. The identification of specific molecular biomarkers is also required for better diagnosis in subtypes of obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteins).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.4103%2fijmr.IJMR_1768_17
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mayoral&issn=0971-5916&title=Indian+Journal+of+Medical+Research&atitle=Obesity+subtypes%2C+related+biomarkers+%26+heterogeneity.&volume=151&issue=1&spage=11&epage=21&date=2020&doi=10.4103%2Fijmr.IJMR_1768_17&pmid=32134010&sid=OVID:medline
+
+<1422>
+Unique Identifier
+ 32131811
+Title
+ Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study.
+Source
+ BMC Endocrine Disorders. 20(1):31, 2020 Mar 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bidulescu A; Dinh PC Jr; Sarwary S; Forsyth E; Luetke MC; King DB; Liu J; Davis SK; Correa A
+Author NameID
+ Bidulescu, Aurelian; ORCID: http://orcid.org/0000-0001-8211-8309
+Authors Full Name
+ Bidulescu, Aurelian; Dinh, Paul C Jr; Sarwary, Shabir; Forsyth, Emily; Luetke, Maya C; King, David B; Liu, Jiankang; Davis, Sharon K; Correa, Adolfo.
+Institution
+ Bidulescu, Aurelian. Department of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA. abidules@indiana.edu.
+ Dinh, Paul C Jr. Department of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
+ Sarwary, Shabir. Department of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
+ Forsyth, Emily. Department of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
+ Luetke, Maya C. Department of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
+ King, David B. Henry M Jackson Foundation for the advancement of Military Medicine, Bethesda, MD, USA.
+ Liu, Jiankang. Brigham and Women's Hospital, Boston, MA, USA.
+ Davis, Sharon K. National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, Bethesda, MD, USA.
+ Correa, Adolfo. Jackson Heart Study at University of Mississippi Medical Center, Jackson, MS, USA.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adult
+ *Black or African American/sn [Statistics & Numerical Data]
+ Aged
+ Aged, 80 and over
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ *Insulin Resistance
+ *Leptin/bl [Blood]
+ Longitudinal Studies
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Risk Factors
+ United States/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ Adiponectin
+ African Americans
+ Gender
+ Insulin resistance
+ Leptin
+ Mediation
+ Obesity
+ Observational cohort
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Growing evidence suggests that leptin is critical for glycemic control. Impaired leptin signaling may also contribute to low adiponectin expression in obese individuals. We assessed the association of leptin and adiponectin with incident type 2 diabetes (T2D), their interactions with sex and obesity status, and mediation by insulin resistance.
+
+ METHODS: We included study participants from the Jackson Heart Study, a prospective cohort of adult African Americans in Jackson, Mississippi, that were free of T2D at the baseline Exam 1. Incident T2D was defined as new cases at Exam 2 or Exam 3. We created separate Cox regression models (hazard ratios per log-transformed ng/mL of leptin and adiponectin) with and without insulin resistance, HOMA-IR. Mediation by insulin resistance was analyzed. Several interactions were assessed, including by sex, HbA1c, and obesity.
+
+ RESULTS: Among our 3363 participants (mean age 53 years, 63% women), 584 developed incident T2D. Leptin was directly associated with incident T2D when modeled without HOMA-IR (HR = 1.29, 95% CI = 1.05-1.58). This direct association between leptin and T2D was significant among men (HR = 1.33, 95% CI = 1.05-1.69), but nonsignificant among women (HR = 1.24, 95% CI = 0.94-1.64); statistical interaction with sex was nonsignificant (p = 0.65). The associations in all participants and in men were nullified by HOMA-IR (HR = 0.99, 95% CI = 0.80-1.22; HR = 1.00, 95% CI = 0.78-1.28, respectively), indicating mediation through insulin resistance (proportion mediated: 1.04), and were not observed in abdominally obese participants. Adiponectin was inversely associated with T2D even after adjustment for HOMA-IR in women (HR = 0.68, 95% CI = 0.55-0.84), but not in men (HR = 0.80, 95% CI = 0.62-1.04). The inverse association was present only among abdominally obese participants, and persisted after adjustment for HOMA-IR.
+
+ CONCLUSIONS: Among African Americans in the Jackson Heart Study the association of leptin with incident type 2 diabetes was mediated by insulin resistance. This association was present only among abdominally non-obese participants. Differences by sex appeared: men showed a significant association mediated by insulin resistance. Among abdominally obese participants, adiponectin was inversely associated with incident T2D even after adjustment for HOMA-IR. Our results should inform future clinical trials that aim to reduce the burden of type 2 diabetes through the modification of serum levels of leptin and adiponectin.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Leptin).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12902-020-0511-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bidulescu&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Associations+of+leptin+and+adiponectin+with+incident+type+2+diabetes+and+interactions+among+African+Americans%3A+the+Jackson+heart+study.&volume=20&issue=1&spage=31&epage=&date=2020&doi=10.1186%2Fs12902-020-0511-z&pmid=32131811&sid=OVID:medline
+
+<1423>
+Unique Identifier
+ 32127335
+Title
+ Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(4):625-633, 2020 04 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kuszewski JC; Wong RHX; Wood LG; Howe PRC
+Authors Full Name
+ Kuszewski, Julia C; Wong, Rachel H X; Wood, Lisa G; Howe, Peter R C.
+Institution
+ Kuszewski, Julia C. Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia.
+ Wong, Rachel H X. Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia; Institute for Resilient Regions, University of Southern Queensland, Springfield Central, Australia.
+ Wood, Lisa G. Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, NSW, Australia.
+ Howe, Peter R C. Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia; Institute for Resilient Regions, University of Southern Queensland, Springfield Central, Australia. Electronic address: peter.howe@newcastle.edu.au.
+MeSH Subject Headings
+ Age Factors
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Blood Pressure/de [Drug Effects]
+ C-Reactive Protein/me [Metabolism]
+ *Cardiovascular System/de [Drug Effects]
+ Cardiovascular System/pp [Physiopathology]
+ *Cerebrovascular Circulation/de [Drug Effects]
+ *Curcumin/ad [Administration & Dosage]
+ Curcumin/ae [Adverse Effects]
+ Dietary Supplements/ae [Adverse Effects]
+ *Dietary Supplements
+ Docosahexaenoic Acids/ad [Administration & Dosage]
+ Double-Blind Method
+ Eicosapentaenoic Acid/ad [Administration & Dosage]
+ Female
+ *Fish Oils/ad [Administration & Dosage]
+ Fish Oils/ae [Adverse Effects]
+ Health Status
+ *Heart Rate/de [Drug Effects]
+ Humans
+ Inflammation Mediators/bl [Blood]
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ New South Wales
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Time Factors
+ Treatment Outcome
+ *Vascular Stiffness/de [Drug Effects]
+Keyword Heading
+ Cerebrovascular function
+ Curcumin
+ Endothelial function
+ Fish oil
+ Inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Chronic conditions such as obesity, which contribute to endothelial dysfunction in older adults, can cause impairments in cerebrovascular perfusion, which is associated with accelerated cognitive decline. Supplementing the diet with bioactive nutrients that can enhance endothelial function, such as fish oil or curcumin, may help to counteract cerebrovascular dysfunction.
+
+ METHODS AND RESULTS: A 16-week double-blind, randomized placebo-controlled trial was undertaken in 152 older sedentary overweight/obese adults (50-80 years, body mass index: 25-40 kg/m2) to investigate effects of fish oil (2000 mg docosahexaenoic acid + 400 mg eicosapentaenoic acid/day), curcumin (160 mg/day) or a combination of both on cerebrovascular function (measured by Transcranial Doppler ultrasound), systemic vascular function (blood pressure, heart rate and arterial compliance) and cardiometabolic (fasting glucose and blood lipids) and inflammatory (C-reactive protein) biomarkers. The primary outcome, cerebrovascular responsiveness to hypercapnia, was not affected by the interventions. However, cerebral artery stiffness was significantly reduced in males following fish oil supplementation (P = 0.007). Furthermore, fish oil reduced heart rate (P = 0.038) and serum triglycerides (P = 0.006) and increased HDL cholesterol (P = 0.002). Curcumin did not significantly affect these outcomes either alone or in combination with fish oil.
+
+ CONCLUSION: Regular supplementation with fish oil but not curcumin improved biomarkers of cardiovascular and cerebrovascular function. The combined supplementation did not result in additional benefits. Further studies are warranted to identify an efficacious curcumin dose and to characterize (in terms of sex, BMI, cardiovascular and metabolic risk factors) populations whose cerebrovascular and cognitive functions might benefit from either intervention.
+
+ CLINICAL TRIAL REGISTRATION: ACTRN12616000732482p. Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Fish Oils). 0 (Inflammation Mediators). 0 (Lipids). 25167-62-8 (Docosahexaenoic Acids). 9007-41-4 (C-Reactive Protein). AAN7QOV9EA (Eicosapentaenoic Acid). IT942ZTH98 (Curcumin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.numecd.2019.12.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kuszewski&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Effects+of+fish+oil+and+curcumin+supplementation+on+cerebrovascular+function+in+older+adults%3A+A+randomized+controlled+trial.&volume=30&issue=4&spage=625&epage=633&date=2020&doi=10.1016%2Fj.numecd.2019.12.010&pmid=32127335&sid=OVID:medline
+
+<1424>
+Unique Identifier
+ 32126014
+Title
+ Comparison of leptin levels in neonates born to mothers with high or low gestational weight gain.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 33(4):517-523, 2020 Apr 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vargas-Aguirre P; Tene CE; Del Toro-Equihua M; Bayardo-Tortolero R; Sanchez-Meza K
+Authors Full Name
+ Vargas-Aguirre, Paulina; Tene, Carlos E; Del Toro-Equihua, Mario; Bayardo-Tortolero, Rosalinda; Sanchez-Meza, Karmina.
+Institution
+ Vargas-Aguirre, Paulina. Universidad de Colima, Faculty of Medicine, Colima, Col., Mexico.
+ Tene, Carlos E. Universidad de Colima, Faculty of Medicine, Colima, Col., Mexico.
+ Del Toro-Equihua, Mario. Universidad de Colima, Faculty of Medicine, Colima, Col., Mexico.
+ Bayardo-Tortolero, Rosalinda. Secretaria de Salud y Bienestar Social, Hospital Regional Universitario, Colima, Col., Mexico.
+ Sanchez-Meza, Karmina. Universidad de Colima, Faculty of Medicine, Colima, Col., Mexico.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Birth Weight
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ *Gestational Weight Gain
+ Humans
+ Infant, Newborn
+ *Leptin/bl [Blood]
+ Male
+ Mexico/ep [Epidemiology]
+ Mothers/sn [Statistics & Numerical Data]
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Pregnancy
+ Pregnancy Complications/bl [Blood]
+ *Pregnancy Complications/ep [Epidemiology]
+ Prenatal Exposure Delayed Effects/bl [Blood]
+ *Prenatal Exposure Delayed Effects/ep [Epidemiology]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ gestational weight gain
+ leptin
+ neonate
+ umbilical cord
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Gestational weight gain (GWG) influences both fetal and maternal health. Leptin is a biomarker that may predict the early development of obesity and greater weight gain in childhood. Newborns with higher neonatal weight have been found to have higher leptin levels in umbilical cord blood (UCB). There are few studies that evaluate leptin levels in UCB according to GWG in women with a normal body mass index (BMI). The aim of the present study was to determine whether the levels of leptin in UCB in neonates born to mothers with a high GWG were higher, compared with levels in newborns whose mothers had a low GWG. Methods A cross-sectional analytic study was conducted on 65 primigravidas. They were under 30 years of age, had normal pregestational BMIs, no associated diseases and were classified as having high (n = 22) or low (n = 43) GWG. The neonatal UCB leptin levels were measured and both neonatal and maternal anthropometric evaluations were carried out. The quantitative variables were compared through the Mann-Whitney U test and Student's t test, as appropriate. Results UCB leptin levels were higher in the neonates whose mothers were in the high GWG group, compared with those born to mothers in the low GWG group (7.0 [1.9-11.4] vs. 2.9 [1.2-6.7] ng/mL, p = 0.020). When stratified by sex, that difference was maintained only in male neonates. Conclusions UCB leptin levels were higher in neonates born to mothers with a high GWG, compared with those in newborns whose mothers had a low GWG.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1515%2fjpem-2019-0356
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vargas-Aguirre&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Comparison+of+leptin+levels+in+neonates+born+to+mothers+with+high+or+low+gestational+weight+gain.&volume=33&issue=4&spage=517&epage=523&date=2020&doi=10.1515%2Fjpem-2019-0356&pmid=32126014&sid=OVID:medline
+
+<1425>
+Unique Identifier
+ 32122201
+Title
+ Association between insulin resistance and risk of atrial fibrillation in non-diabetics.
+Source
+ European Journal of Preventive Cardiology. 27(18):1934-1941, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee Y; Cha SJ; Park JH; Shin JH; Lim YH; Park HC; Shin J; Kim CK; Park JK
+Authors Full Name
+ Lee, Yonggu; Cha, Sung Joo; Park, Jung-Hwan; Shin, Jeong-Hun; Lim, Young-Hyo; Park, Hwan-Cheol; Shin, Jinho; Kim, Chun Ki; Park, Jin-Kyu.
+Institution
+ Lee, Yonggu. Division of Cardiology, Hanyang University Guri Hospital, Republic of Korea.
+ Cha, Sung Joo. Division of Cardiology, Hanyang University Medical Center, Republic of Korea.
+ Park, Jung-Hwan. Division of Endocrinology and Metabolism, Hanyang University Medical Center, Republic of Korea.
+ Shin, Jeong-Hun. Division of Cardiology, Hanyang University Guri Hospital, Republic of Korea.
+ Lim, Young-Hyo. Division of Cardiology, Hanyang University Medical Center, Republic of Korea.
+ Park, Hwan-Cheol. Division of Cardiology, Hanyang University Guri Hospital, Republic of Korea.
+ Shin, Jinho. Division of Cardiology, Hanyang University Medical Center, Republic of Korea.
+ Kim, Chun Ki. Department of Medicine, Hanyang University College of Medicine, Republic of Korea.
+ Park, Jin-Kyu. Division of Cardiology, Hanyang University Medical Center, Republic of Korea.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Aged
+ Atrial Fibrillation/bl [Blood]
+ Atrial Fibrillation/ep [Epidemiology]
+ *Atrial Fibrillation/et [Etiology]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Diabetes Mellitus
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ *Insulin/bl [Blood]
+ Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Republic of Korea/ep [Epidemiology]
+ Retrospective Studies
+ *Risk Assessment/mt [Methods]
+ Risk Factors
+Keyword Heading
+ Insulin resistance
+ atrial fibrillation
+ epidemiology
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population.
+
+ METHODS: Between 2001-2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation.
+
+ RESULTS: Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14-2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1-2.5, and then plateaued afterwards (p = 0.031).
+
+ CONCLUSION: There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1177%2f2047487320908706
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=2047-4873&title=European+Journal+of+Preventive+Cardiology&atitle=Association+between+insulin+resistance+and+risk+of+atrial+fibrillation+in+non-diabetics.&volume=27&issue=18&spage=1934&epage=1941&date=2020&doi=10.1177%2F2047487320908706&pmid=32122201&sid=OVID:medline
+
+<1426>
+Unique Identifier
+ 32120804
+Title
+ Alliin, an Allium sativum Nutraceutical, ReducesMetaflammation Markers in DIO Mice.
+Source
+ Nutrients. 12(3), 2020 Feb 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sanchez-Sanchez MA; Zepeda-Morales ASM; Carrera-Quintanar L; Viveros-Paredes JM; Franco-Arroyo NN; Godinez-Rubi M; Ortuno-Sahagun D; Lopez-Roa RI
+Authors Full Name
+ Sanchez-Sanchez, Marina A; Zepeda-Morales, Adelaida Sara Minia; Carrera-Quintanar, Lucrecia; Viveros-Paredes, Juan Manuel; Franco-Arroyo, Noel Noe; Godinez-Rubi, Marisol; Ortuno-Sahagun, Daniel; Lopez-Roa, Rocio Ivette.
+Institution
+ Sanchez-Sanchez, Marina A. Laboratorio de Neuroinmunobiologia Molecular, Instituto de Investigacion en Ciencias Biomedicas (IICB)CUCS, Universidad de Guadalajara, Guadalajara Jalisco 44340, Mexico.
+ Sanchez-Sanchez, Marina A. Laboratorio de Investigacion y Desarrollo Farmaceutico, CUCEI, Universidad de Guadalajara, GuadalajaraJalisco 44430, Mexico.
+ Zepeda-Morales, Adelaida Sara Minia. Laboratorio de Investigacion y Desarrollo Farmaceutico, CUCEI, Universidad de Guadalajara, GuadalajaraJalisco 44430, Mexico.
+ Carrera-Quintanar, Lucrecia. Laboratorio de Ciencias de los Alimentos, Departamento de Reproduccion Humana, Crecimiento yDesarrollo Infantil, CUCS, Universidad de Guadalajara, Guadalajara Jalisco 44340, Mexico.
+ Viveros-Paredes, Juan Manuel. Laboratorio de Investigacion y Desarrollo Farmaceutico, CUCEI, Universidad de Guadalajara, GuadalajaraJalisco 44430, Mexico.
+ Franco-Arroyo, Noel Noe. Laboratorio de Investigacion y Desarrollo Farmaceutico, CUCEI, Universidad de Guadalajara, GuadalajaraJalisco 44430, Mexico.
+ Godinez-Rubi, Marisol. Laboratorio de Investigacion en Patologia, Departamento de Microbiologia y Patologia, CUCS,Universidad de Guadalajara, Guadalajara Jalisco 44340, Mexico.
+ Ortuno-Sahagun, Daniel. Laboratorio de Neuroinmunobiologia Molecular, Instituto de Investigacion en Ciencias Biomedicas (IICB)CUCS, Universidad de Guadalajara, Guadalajara Jalisco 44340, Mexico.
+ Lopez-Roa, Rocio Ivette. Laboratorio de Investigacion y Desarrollo Farmaceutico, CUCEI, Universidad de Guadalajara, GuadalajaraJalisco 44430, Mexico.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Cysteine/aa [Analogs & Derivatives]
+ Cysteine/ch [Chemistry]
+ Cysteine/pd [Pharmacology]
+ *Dietary Supplements
+ *Garlic/ch [Chemistry]
+ Gene Expression Regulation/de [Drug Effects]
+ Inflammation/bl [Blood]
+ Inflammation/ci [Chemically Induced]
+ Inflammation/dt [Drug Therapy]
+ Male
+ Mice
+ Obesity/bl [Blood]
+ Obesity/ci [Chemically Induced]
+ Obesity/dt [Drug Therapy]
+ *Obesity
+Keyword Heading
+ adipocytokines
+ adipose tissue
+ cytokines
+ inflammation
+ obesity
+ s-allyl cysteine sulfoxide
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity generates a chronic low-grade inflammatory state which promotes oxidativestress and triggers comorbidities. Alliin is the main organosulfur compound in garlic and has beenshown to induce a decrease in the expression of proinflammatory cytokines; its systemic effect onmetabolic parameters and adipose tissue is not yet known, however. After nine weeks of HFD andwith obesity established in C57BL/6 mice, we observed that a daily treatment with alliin for 3.5weeks (15 mg/kg) did not affect body weight, but significantly improved insulin sensitivity andglucose tolerance, both evaluated through a blood glucose monitoring system. Once alliin treatmentwas completed, serum, adipose tissue, and organs of interest related to metabolism were removedfor further analysis. We observed that alliin significantly decreased the size of adipocytes fromepididymal adipose tissue, evaluated via microscopy. A decrease in gene expression and serumprotein levels of the adipocytokines leptin and resistin, as well as decreased serum IL-6concentration, were detected by qRT-PCR and ELISA, respectively. It did not, however, affectmRNA expression of antioxidant enzymes in the liver. Taken altogether, these results indicate thattreatment with alliin reduces metaflammation markers in DIO mice and improves some metabolicparameters without affecting others.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Blood Glucose). 0 (aliin). K848JZ4886 (Cysteine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12030624
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sanchez-Sanchez&issn=2072-6643&title=Nutrients&atitle=Alliin%2C+an+Allium+sativum+Nutraceutical%2C+ReducesMetaflammation+Markers+in+DIO+Mice.&volume=12&issue=3&spage=&epage=&date=2020&doi=10.3390%2Fnu12030624&pmid=32120804&sid=OVID:medline
+
+<1427>
+Unique Identifier
+ 32114327
+Title
+ The effect of type 2 diabetes diagnosis in the elderly.
+Source
+ Economics & Human Biology. 37:100830, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gaggero A
+Authors Full Name
+ Gaggero, Alessio.
+Institution
+ Gaggero, Alessio. University of Granada, Department of Applied Economics, Cartuja Campus, 18011, Granada, Spain. Electronic address: alessiogaggero@go.ugr.es.
+MeSH Subject Headings
+ Activities of Daily Living
+ Age Factors
+ Aged
+ Biomarkers
+ Body Mass Index
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/pp [Physiopathology]
+ *Diabetes Mellitus, Type 2/px [Psychology]
+ Female
+ Health Behavior
+ Humans
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Models, Econometric
+ Obesity/ep [Epidemiology]
+ Physical Functional Performance
+ Sex Factors
+ Waist Circumference
+Keyword Heading
+ Biomarkers
+ RDD
+ Type 2 diabetes diagnosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In this paper, I use a novel approach based on biomarkers data to examine the effect of type 2 diabetes (T2D) diagnosis on both physical and mental health for a sample of individuals aged 50 and above. In order to retrieve reliable estimates, I exploit the fact that medical guidelines cause a discontinuity in the probability that General Practitioners (GP) diagnose their patients with T2D as a function of exact blood test cut-off in a regression discontinuity design (RDD) approach. Using data from the English Longitudinal Study of Ageing (ELSA), I find compelling evidence that health information, in the form of T2D diagnosis, influences the protection of health into old age. Specifically, after receiving T2D diagnosis, over time, individuals reported a 2.1 lower body mass index (BMI) as well as 5.5 cm lower waist circumference, relative to their counterparts. With respect to self-reported physical health, the results imply that those diagnosed with T2D reported a 0.19 and 0.70 higher score in increased activities of daily living (ADL) and body mobility indexes, respectively. Finally, while I find evidence that T2D-diagnosed patients reported a significant, 0.5 higher, score in the word listening test, I find no evidence that T2D diagnosis impacted self-reported depression levels. I provide a wide variety of evidence on the validity of the results. Copyright © 2020 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.ehb.2019.100830
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gaggero&issn=1570-677X&title=Economics+%26+Human+Biology&atitle=The+effect+of+type+2+diabetes+diagnosis+in+the+elderly.&volume=37&issue=&spage=100830&epage=&date=2020&doi=10.1016%2Fj.ehb.2019.100830&pmid=32114327&sid=OVID:medline
+
+<1428>
+Unique Identifier
+ 32111165
+Title
+ Peripheral arterial disease and its correlates in patients with type 2 diabetes mellitus in a teaching hospital in northern Nigeria: a cross-sectional study.
+Source
+ BMC Cardiovascular Disorders. 20(1):102, 2020 02 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Agboghoroma OF; Akemokwe FM; Puepet FH
+Author NameID
+ Agboghoroma, Orighomisan Freda; ORCID: https://orcid.org/0000-0001-8130-2200
+Authors Full Name
+ Agboghoroma, Orighomisan Freda; Akemokwe, Fatai Momodu; Puepet, Fabian H.
+Institution
+ Agboghoroma, Orighomisan Freda. Jos University Teaching Hospital, Jos, Plateau State, Nigeria. misan.aroma@gmail.com.
+ Agboghoroma, Orighomisan Freda. Present address: Medical Research Council at the London School of Hygiene and Tropical Medicine, Fajara, Gambia. misan.aroma@gmail.com.
+ Akemokwe, Fatai Momodu. Present address: Medical Research Council at the London School of Hygiene and Tropical Medicine, Fajara, Gambia.
+ Puepet, Fabian H. Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Ankle Brachial Index
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cholesterol, HDL/bl [Blood]
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/ep [Epidemiology]
+ Female
+ *Hospitals, Teaching
+ Humans
+ Male
+ Middle Aged
+ Nigeria/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Peripheral Arterial Disease/di [Diagnosis]
+ *Peripheral Arterial Disease/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ Correlates
+ Diabetes mellitus
+ Nigeria
+ Peripheral arterial disease
+ Type 2
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Peripheral arterial disease (PAD) is a risk factor for diabetic foot ulcer, limb amputation as well as coronary heart disease. It is more common in patients with diabetes mellitus (DM) and co-exists with peripheral neuropathy. Prevalence of PAD in type 2 DM patients in northern Nigeria is largely unknown. We investigated the occurrence and factors associated with PAD among patients with type 2 DM in a tertiary hospital in northern Nigeria.
+
+ METHODS: This was a cross- sectional analytic study. We recruited 200 patients with type 2 DM consecutively from the diabetes clinic of the Jos University Teaching Hospital. Ankle brachial index was assessed for each participant. Clinical information, anthropometric indices and blood samples were collected for assay. Data was analysed using CDC Epi-Info and logistic regression analysis was used to determine independent correlates of PAD.
+
+ RESULTS: PAD was present in 38.5%(n = 77) of subjects and it was associated with the female sex, age >= 50 years, Body mass index (BMI) >= 25 kg/m2 and low HDL cholesterol levels. However, on multiple logistic regression, a BMI >= 25 kg/m2 and a low HDL cholesterol level were independent correlates of PAD(adjusted OR = 2.13,95% CI = 1.04-4.36 and adjusted OR = 2.31, 95% CI = 1.04-5.15, respectively).
+
+ CONCLUSION: PAD is present in more than a third of patients with type 2 DM in a tertiary hospital in northern Nigeria. A BMI of >=25 kg/m2 and low HDL cholesterol levels were independent correlates of PAD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12872-020-01395-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Agboghoroma&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Peripheral+arterial+disease+and+its+correlates+in+patients+with+type+2+diabetes+mellitus+in+a+teaching+hospital+in+northern+Nigeria%3A+a+cross-sectional+study.&volume=20&issue=1&spage=102&epage=&date=2020&doi=10.1186%2Fs12872-020-01395-3&pmid=32111165&sid=OVID:medline
+
+<1429>
+Unique Identifier
+ 32106801
+Title
+ Relation of Steatosis to Neurocognitive Function in People Living with HIV.
+Source
+ Current HIV Research. 18(3):172-180, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Maric D; Brkic S; Ignjatovic VB; Nikolasevic Z; Ilic D; Vujanovic M; Drvendzija Z; Galic BS
+Authors Full Name
+ Maric, Daniela; Brkic, Snezana; Ignjatovic, Vojislava Bugarski; Nikolasevic, Zeljka; Ilic, Dalibor; Vujanovic, Milos; Drvendzija, Zorka; Galic, Biljana Srdic.
+Institution
+ Maric, Daniela. Deparment of Infectious Diseases, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
+ Brkic, Snezana. Deparment of Infectious Diseases, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
+ Ignjatovic, Vojislava Bugarski. Department of Psychology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
+ Nikolasevic, Zeljka. Department of Psychology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
+ Ilic, Dalibor. Clinic for Radiology, Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia.
+ Vujanovic, Milos. Deparment of Infectious Diseases, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
+ Drvendzija, Zorka. Department of Anathomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
+ Galic, Biljana Srdic. Department of Anathomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
+MeSH Subject Headings
+ Adult
+ Aged
+ Anti-HIV Agents/tu [Therapeutic Use]
+ Antiretroviral Therapy, Highly Active
+ Biomarkers/bl [Blood]
+ CD4 Lymphocyte Count
+ CD4-Positive T-Lymphocytes/me [Metabolism]
+ CD4-Positive T-Lymphocytes/vi [Virology]
+ Carotid Intima-Media Thickness
+ Cognitive Dysfunction/bl [Blood]
+ *Cognitive Dysfunction/co [Complications]
+ Cognitive Dysfunction/pp [Physiopathology]
+ Cognitive Dysfunction/vi [Virology]
+ Cross-Sectional Studies
+ Fatty Liver/bl [Blood]
+ *Fatty Liver/co [Complications]
+ Fatty Liver/pp [Physiopathology]
+ Fatty Liver/vi [Virology]
+ HIV/gd [Growth & Development]
+ HIV/py [Pathogenicity]
+ HIV Infections/bl [Blood]
+ *HIV Infections/co [Complications]
+ HIV Infections/pp [Physiopathology]
+ HIV Infections/vi [Virology]
+ Humans
+ Interleukin-6/bl [Blood]
+ Intra-Abdominal Fat/pa [Pathology]
+ Male
+ Memory, Short-Term/ph [Physiology]
+ Mental Recall/ph [Physiology]
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/pp [Physiopathology]
+ Metabolic Syndrome/vi [Virology]
+ Middle Aged
+ Neuropsychological Tests
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Obesity/vi [Virology]
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ PLWH
+ central obesity
+ metabolic syndrome
+ neurocognition
+ steatosis.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In HIV negative population metabolic syndrome and steatosis are related to poorer neurocognitive (NC) performance. We investigated if similar relation exists in people living with HIV (PLWH).
+
+ METHODS: We included male PLWH aged 20-65, with undetectable viral load for at least 6 months. Data on levels of education, anthropometric measurements, CD4 levels, ART, markers of metabolic syndrome, smoking and concurrent treatment were collected from database. Concentrations of TNF-alpha and IL-6 were measured. An ultrasound was used to establish the presence of steatosis, visceral fat thickness and carotid intima media thickness. An extensive NC assessment was done by an experienced neuropsychologist. Cognitive domains were defined as executive functions, divergent reasoning, visuo-constructional abilities, delayed recall and working memory and learning and were measured using a battery of 12 tests.
+
+ RESULTS: 88 PLWH were included (mean age 39,9 years), 51% on PIs, 46% on NNRTI; 20,4% had metabolic syndrome, 42% patients had steatosis. Weak but statistically significant negative correlations were found between the presence of metabolic syndrome, steatosis and VFT and cognitive domains (divergent reasoning, delayed recall and working memory). Poorer perfomrance in the domains of divergent reasoning and in the working memory were found in participants with steatosis (p=0,048 and 0,033 respectively).
+
+ CONCLUSION: Although the sample size was relatively small, our results show consistent correlations between the observed neurocognitive variables and metabolic parameters. As central obesity is one of the contributors to NCI, it would be one of the modifiable factors to prevent further neurocognitive decline. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Anti-HIV Agents). 0 (Biomarkers). 0 (IL6 protein, human). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.2174%2f1570162X18666200227114310
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Maric&issn=1570-162X&title=Current+HIV+Research&atitle=Relation+of+Steatosis+to+Neurocognitive+Function+in+People+Living+with+HIV.&volume=18&issue=3&spage=172&epage=180&date=2020&doi=10.2174%2F1570162X18666200227114310&pmid=32106801&sid=OVID:medline
+
+<1430>
+Unique Identifier
+ 32104715
+Title
+ Obesity Enhances Antioxidant Capacity and Reduces Cytokine Levels of the Spleen in Mice to Resist Splenic Injury Challenged by Escherichia coli.
+Source
+ Journal of Immunological Research. 2020:5948256, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gu X; Ma Z; Fang J; Cai D; Zuo Z; Liang S; Cui H; Deng J; Ma X; Ren Z; Geng Y; Zhang M; Ye G; Xie Y; Gou L; Hu Y
+Author NameID
+ Gu, Xuchu; ORCID: https://orcid.org/0000-0001-5719-1045
+ Fang, Jing; ORCID: https://orcid.org/0000-0001-8593-378X
+ Zuo, Zhicai; ORCID: https://orcid.org/0000-0002-5547-4436
+ Cui, Hengmin; ORCID: https://orcid.org/0000-0003-2963-531X
+ Deng, Junliang; ORCID: https://orcid.org/0000-0002-7159-1923
+ Geng, Yi; ORCID: https://orcid.org/0000-0001-7833-6303
+ Zhang, Ming; ORCID: https://orcid.org/0000-0003-2728-128X
+Authors Full Name
+ Gu, Xuchu; Ma, Zhiyu; Fang, Jing; Cai, Dongjie; Zuo, Zhicai; Liang, Shuang; Cui, Hengmin; Deng, Junliang; Ma, Xiaoping; Ren, Zhihua; Geng, Yi; Zhang, Ming; Ye, Gang; Xie, Yue; Gou, Liping; Hu, Yanchun.
+Institution
+ Gu, Xuchu. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Ma, Zhiyu. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Fang, Jing. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Cai, Dongjie. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Zuo, Zhicai. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Liang, Shuang. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Cui, Hengmin. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Deng, Junliang. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Ma, Xiaoping. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Ren, Zhihua. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Geng, Yi. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Zhang, Ming. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Ye, Gang. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Xie, Yue. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Gou, Liping. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+ Hu, Yanchun. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu Sichuan Province 611130, China.
+MeSH Subject Headings
+ Animals
+ *Antioxidants/me [Metabolism]
+ Biomarkers
+ Biopsy
+ *Cytokines/me [Metabolism]
+ Disease Models, Animal
+ *Escherichia coli
+ Escherichia coli Infections/di [Diagnosis]
+ *Escherichia coli Infections/me [Metabolism]
+ *Escherichia coli Infections/mi [Microbiology]
+ Fibrosis
+ Mice
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Oxidative Stress
+ *Spleen/me [Metabolism]
+ *Spleen/mi [Microbiology]
+ Spleen/pa [Pathology]
+ Symptom Assessment
+Abstract
+ Obese mice exhibited more lymphocytes in the bronchoalveolar lavage fluid and milder lung injury after Escherichia coli (E. coli) infection. However, it remained unclear whether the spleen contributed to the effect of obese mice with infection. The study was purposed to reveal the histopathological changes of the spleen caused by oxidative stress and inflammation in diet-induced obesity (DIO) mice challenged by Escherichia coli. After infection, the spleen tissues were obtained in normal and DIO mice at 0 h (uninfected), 12 h, 24 h, and 72 h postinfection. Results revealed that DIO mice have higher contents of resistin, TNF-alpha, IL-6, and IL-1beta in the spleen than normal mice and lower concentrations of GSH-Px, SOD, and CAT and higher MDA than normal mice. After an intranasal drip of E. coli, the activities of GSH-Px, SOD, and CAT in the DIO mice were elevated and the content of MDA declined. The activities of SOD and CAT in the normal mice declined, and the content of MDA was elevated. Moreover, the contents of TNF-alpha, IL-6, and IL-1beta in the spleen declined in DIO mice at 24 and 72 h, although the contents of leptin, resistin, TNF-alpha, IL-6, and IL-1beta were elevated at 12 h. The contents of resistin, TNF-alpha, IL-6, and IL-1beta were elevated in normal mice at 12 and 24 h. Those results indicated that obesity elevated splenic oxidation and inflammatory levels, but it enhanced antioxidant capacity and reduced cytokine levels of the spleen in mice to resist splenic injury after an intranasal drip of E. coli. Copyright © 2020 Xuchu Gu et al.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1155%2f2020%2f5948256
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gu&issn=2314-7156&title=Journal+of+Immunological+Research&atitle=Obesity+Enhances+Antioxidant+Capacity+and+Reduces+Cytokine+Levels+of+the+Spleen+in+Mice+to+Resist+Splenic+Injury+Challenged+by+Escherichia+coli.&volume=2020&issue=&spage=5948256&epage=&date=2020&doi=10.1155%2F2020%2F5948256&pmid=32104715&sid=OVID:medline
+
+<1431>
+Unique Identifier
+ 32100190
+Title
+ Endogenous estradiol and inflammation biomarkers: potential interacting mechanisms of obesity-related disease.
+Source
+ Cancer Causes & Control. 31(4):309-320, 2020 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Eldridge RC; Wentzensen N; Pfeiffer RM; Brinton LA; Hartge P; Guillemette C; Kemp TJ; Pinto LA; Trabert B
+Author NameID
+ Eldridge, Ronald C; ORCID: http://orcid.org/0000-0003-0221-7775
+Authors Full Name
+ Eldridge, Ronald C; Wentzensen, Nicolas; Pfeiffer, Ruth M; Brinton, Louise A; Hartge, Patricia; Guillemette, Chantal; Kemp, Troy J; Pinto, Ligia A; Trabert, Britton.
+Institution
+ Eldridge, Ronald C. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. ronald.eldridge@emory.edu.
+ Eldridge, Ronald C. Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA. ronald.eldridge@emory.edu.
+ Wentzensen, Nicolas. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
+ Pfeiffer, Ruth M. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
+ Brinton, Louise A. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
+ Hartge, Patricia. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
+ Guillemette, Chantal. Pharmacogenetics Laboratory, Faculty of Pharmacy, Centre Hospitalier Universitaire (CHU) de Quebec Research Center, Laval University, Quebec City, QC, Canada.
+ Kemp, Troy J. HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, USA.
+ Pinto, Ligia A. HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, USA.
+ Trabert, Britton. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ Aged
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Cytokines/bl [Blood]
+ *Estradiol/bl [Blood]
+ Female
+ Humans
+ *Inflammation/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Odds Ratio
+Keyword Heading
+ Cytokines
+ Endogenous estradiol
+ Inflammation
+ Obesity
+ Serum biomarkers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Disentangling the effects of endogenous estrogens and inflammation on obesity-related diseases requires a clearer understanding of how the two biological mechanisms relate to each other.
+
+ METHODS: We studied 155 healthy postmenopausal women not taking menopausal hormone therapy enrolled in the Prostate Lung Colorectal and Ovarian (PLCO) screening cancer trial. From a baseline blood draw, we measured endogenous estradiol and 69 inflammation biomarkers: cytokines, chemokines, adipokines, angiogenic factors, growth factors, acute phase proteins, and soluble receptors. We evaluated the estradiol-inflammation relationship by assessing associations across different models (linear, ordinal logistic, and binary logistic) using a variety of estradiol classifications. We additionally investigated the estradiol-inflammation relationship stratified by baseline obesity status (BMI < 30 stratum and BMI > 30 stratum).
+
+ RESULTS: Associations of estradiol with 7 inflammation biomarkers met p < 0.05 statistical significance in linear and ordinal models: C-reactive protein (CRP), adiponectin, chemokine (C-X-C motif) ligand-6, thymus activation-regulated chemokine, eosinophil chemotactic protein, plasminogen activator inhibitor-1, and serum amyloid A. The positive association between estradiol and CRP was robust to model changes. Each standard deviation increase in endogenous estradiol doubled a woman's odds of having CRP levels higher than the study median (odds ratio 2.29; 95% confidence interval 1.28, 4.09). Estradiol was consistently inversely associated with adiponectin. Other estradiol-inflammation biomarker associations were not robust to model changes.
+
+ CONCLUSIONS: Endogenous estradiol appears to be associated with CRP and adiponectin; the evidence is limited for other inflammation biomarkers.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cytokines). 4TI98Z838E (Estradiol). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs10552-020-01280-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Eldridge&issn=0957-5243&title=Cancer+Causes+%26+Control&atitle=Endogenous+estradiol+and+inflammation+biomarkers%3A+potential+interacting+mechanisms+of+obesity-related+disease.&volume=31&issue=4&spage=309&epage=320&date=2020&doi=10.1007%2Fs10552-020-01280-6&pmid=32100190&sid=OVID:medline
+
+<1432>
+Unique Identifier
+ 32099721
+Title
+ Impact of age on host responses to diet-induced obesity: Development of joint damage and metabolic set points.
+Source
+ Journal of Sport & Health Science. 9(2):132-139, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Collins KH; MacDonald GZ; Hart DA; Seerattan RA; Rios JL; Reimer RA; Herzog W
+Authors Full Name
+ Collins, Kelsey H; MacDonald, Graham Z; Hart, David A; Seerattan, Ruth A; Rios, Jaqueline L; Reimer, Raylene A; Herzog, Walter.
+Institution
+ Collins, Kelsey H. Human Performance Laboratory, University of Calgary, Calgary, AB T2N 1N4, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, AB T2N 1N4, Canada; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63108, USA.
+ MacDonald, Graham Z. Human Performance Laboratory, University of Calgary, Calgary, AB T2N 1N4, Canada.
+ Hart, David A. Human Performance Laboratory, University of Calgary, Calgary, AB T2N 1N4, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, AB T2N 1N4, Canada; Bone & Joint Health Strategic Clinical Network, Alberta Health Services, Edmonton, AB T5E 4E3, Canada.
+ Seerattan, Ruth A. Human Performance Laboratory, University of Calgary, Calgary, AB T2N 1N4, Canada.
+ Rios, Jaqueline L. Human Performance Laboratory, University of Calgary, Calgary, AB T2N 1N4, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, AB T2N 1N4, Canada.
+ Reimer, Raylene A. Human Performance Laboratory, University of Calgary, Calgary, AB T2N 1N4, Canada; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, AB T2N 1N4, Canada.
+ Herzog, Walter. Human Performance Laboratory, University of Calgary, Calgary, AB T2N 1N4, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, AB T2N 1N4, Canada. Electronic address: wherzog@ucalgary.ca.
+MeSH Subject Headings
+ Age Factors
+ Animals
+ Biomarkers/bl [Blood]
+ Body Fat Distribution
+ Body Mass Index
+ Cytokines/bl [Blood]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Humans
+ Inflammation Mediators/bl [Blood]
+ Male
+ *Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Osteoarthritis, Knee/et [Etiology]
+ Osteoarthritis, Knee/pa [Pathology]
+ Rats, Sprague-Dawley
+Keyword Heading
+ Adult exposure
+ High-fat, high-sucrose diet
+ Rat obesity model
+ Serum biomarkers
+ Weanling exposure
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Osteoarthritis is one of the leading causes of pain and disability worldwide, and a large percentage of patients with osteoarthritis are individuals who are also obese. In recent years, a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage (both with and without the superimposition of trauma), which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory mediators. Of note, there is a disparity between whether the dietary challenges commence at weaning, representing a weanling onset, or at skeletal maturity, representing an adult onset of obesity. We wished to evaluate the effect of the dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose (HFS) diet to determine whether these factors may result in disparate outcomes, as there is evidence suggesting that these factors result in differential metabolic disturbances. Based on dietary exposure time, we hypothesized that rats fed an HFS diet for 14 weeks from weaning (HFS Weanling) would demonstrate an increase in knee joint damage scores, whereas rats exposed to the HFS diet for 4 weeks, starting at 12 weeks of age (HFS Adult) and rats exposed to a standard chow diet (Chow) would not display an increase in knee joint damage scores.
+
+ Methods: Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning (HFS Weanling) or an HFS diet for 4 weeks, starting at 12 weeks of age (HFS Adult). At sacrifice, joints were scored using the modified Mankin Criteria, and serum was analyzed for a defined subset of inflammatory markers (Interleukin-6, leptin, monocyte chemoattractant protein-1, and tumor necrosis factor alpha).
+
+ Results: When the HFS Weanling and HFS Adult groups were compared, both groups had a similar percent of body fat, although the HFS Weanling group had a significantly greater body mass than the HFS Adult group. The HFS Weanling and HFS Adult animals had a significant increase in body mass and percentage of body fat when compared to the Chow group. Although knee joint damage scores were low in all 3 groups, we found, contrary to our hypothesis, that the HFS Adult group had statistically significant greater knee joint damage scores than the Chow and HFS Weanling groups. Furthermore, we observed that the HFS Weanling group did not have significant differences in knee joint damage scores relative to the Chow group.
+
+ Conclusion: These findings indicate that the HFS Weanling animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group. Interestingly, when assessing various serum proinflammatory markers, no significant differences were detected between the HFS Adult and HFS Weanling groups. Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated, these findings indicate that dietary exposure time maybe less important than the age at which an HFS diet is introduced. Moreover, increases in serum proinflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may be partially responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet. Copyright © 2019 Published by Elsevier B.V. on behalf of Shanghai University of Sport.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.jshs.2019.06.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Collins&issn=2213-2961&title=Journal+of+Sport+%26+Health+Science&atitle=Impact+of+age+on+host+responses+to+diet-induced+obesity%3A+Development+of+joint+damage+and+metabolic+set+points.&volume=9&issue=2&spage=132&epage=139&date=2020&doi=10.1016%2Fj.jshs.2019.06.004&pmid=32099721&sid=OVID:medline
+
+<1433>
+Unique Identifier
+ 32093387
+Title
+ Evaluation of Transcriptomic Regulations behind Metabolic Syndrome in Obese and Lean Subjects.
+Source
+ International Journal of Molecular Sciences. 21(4), 2020 Feb 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Paczkowska-Abdulsalam M; Niemira M; Bielska A; Szalkowska A; Raczkowska BA; Junttila S; Gyenesei A; Adamska-Patruno E; Maliszewska K; Citko A; Szczerbinski L; Kretowski A
+Author NameID
+ Paczkowska-Abdulsalam, Magdalena; ORCID: https://orcid.org/0000-0001-7158-6983
+ Niemira, Magdalena; ORCID: https://orcid.org/0000-0002-0701-4961
+ Adamska-Patruno, Edyta; ORCID: https://orcid.org/0000-0002-8805-0744
+ Maliszewska, Katarzyna; ORCID: https://orcid.org/0000-0001-5721-2571
+ Szczerbinski, Lukasz; ORCID: https://orcid.org/0000-0002-6201-0605
+ Kretowski, Adam; ORCID: https://orcid.org/0000-0002-4522-4978
+Authors Full Name
+ Paczkowska-Abdulsalam, Magdalena; Niemira, Magdalena; Bielska, Agnieszka; Szalkowska, Anna; Raczkowska, Beata Anna; Junttila, Sini; Gyenesei, Attila; Adamska-Patruno, Edyta; Maliszewska, Katarzyna; Citko, Anna; Szczerbinski, Lukasz; Kretowski, Adam.
+Institution
+ Paczkowska-Abdulsalam, Magdalena. Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Niemira, Magdalena. Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Bielska, Agnieszka. Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Szalkowska, Anna. Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Raczkowska, Beata Anna. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Junttila, Sini. Vienna Biocenter Core Facilities, Dr.-Bohr-Gasse 3, 1030 Vienna, Austria.
+ Gyenesei, Attila. Vienna Biocenter Core Facilities, Dr.-Bohr-Gasse 3, 1030 Vienna, Austria.
+ Adamska-Patruno, Edyta. Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Maliszewska, Katarzyna. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Citko, Anna. Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Szczerbinski, Lukasz. Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Kretowski, Adam. Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+ Kretowski, Adam. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Female
+ *Gene Expression Profiling
+ *Gene Expression Regulation
+ Humans
+ Male
+ Metabolic Syndrome/ge [Genetics]
+ *Metabolic Syndrome/me [Metabolism]
+ Middle Aged
+ Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ *Transcriptome
+Keyword Heading
+ cardiovascular disease
+ metabolic syndrome
+ obesity
+ obesity phenotypes
+ transcriptomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Multiple mechanisms have been suggested to confer to the pathophysiology of metabolic syndrome (MetS), however despite great interest from the scientific community, the exact contribution of each of MetS risk factors still remains unclear. The present study aimed to investigate molecular signatures in peripheral blood of individuals affected by MetS and different degrees of obesity. Metabolic health of 1204 individuals from 1000PLUS cohort was assessed, and 32 subjects were recruited to four study groups: MetS lean, MetS obese, "healthy obese", and healthy lean. Whole-blood transcriptome next generation sequencing with functional data analysis were carried out. MetS obese and MetS lean study participants showed the upregulation of genes involved in inflammation and coagulation processes: granulocyte adhesion and diapedesis (p < 0.0001, p = 0.0063), prothrombin activation pathway (p = 0.0032, p = 0.0091), coagulation system (p = 0.0010, p = 0.0155). The results for "healthy obese" indicate enrichment in molecules associated with protein synthesis (p < 0.0001), mitochondrial dysfunction (p < 0.0001), and oxidative phosphorylation (p < 0.0001). Our results suggest that MetS is related to the state of inflammation and vascular system changes independent of excess body weight. Furthermore, "healthy obese", despite not fulfilling the criteria for MetS diagnosis, seems to display an intermediate state with a lower degree of metabolic abnormalities, before they proceed to a full blown MetS.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijms21041455
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Paczkowska-Abdulsalam&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Evaluation+of+Transcriptomic+Regulations+behind+Metabolic+Syndrome+in+Obese+and+Lean+Subjects.&volume=21&issue=4&spage=1455&epage=&date=2020&doi=10.3390%2Fijms21041455&pmid=32093387&sid=OVID:medline
+
+<1434>
+Unique Identifier
+ 32092502
+Title
+ Osteosarcopenic obesity markers following elastic band resistance training: A randomized controlled trial.
+Source
+ Experimental Gerontology. 135:110884, 2020 07 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Banitalebi E; Faramarzi M; Ghahfarokhi MM; SavariNikoo F; Soltani N; Bahramzadeh A
+Authors Full Name
+ Banitalebi, Ebrahim; Faramarzi, Mohammad; Ghahfarokhi, Majid Mardaniyan; SavariNikoo, Farideh; Soltani, Neda; Bahramzadeh, Azita.
+Institution
+ Banitalebi, Ebrahim. Department of Sport Sciences, Shahrekord University, Shahrekord, Iran. Electronic address: banitalebi@sku.ac.ir.
+ Faramarzi, Mohammad. Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
+ Ghahfarokhi, Majid Mardaniyan. Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
+ SavariNikoo, Farideh. Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
+ Soltani, Neda. Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
+ Bahramzadeh, Azita. Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Aged
+ Aged, 80 and over
+ Biomarkers
+ Female
+ Hand Strength
+ Humans
+ Obesity/th [Therapy]
+ *Resistance Training
+Keyword Heading
+ Osteosarcopenic obesity markers
+ Randomized controlled trial
+ Resistance training
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The main purpose of present study was to investigate the effects of elastic band resistance training (EBRT) on muscle quality (MQ), serum osteosarcopenic obesity (OSO) biomarkers, bone density and functional profile in women living with OSO syndrome. The eligible participants, aged 65 to 80 years, were selected by a physician. Accordingly, a total number of 63 women with OSO syndrome were recruited and assessed using a dual energy X-ray absorptiometry (DXA) instrument, body mass index (BMI) > 30 kg/m2, -2.5 <= T-score <= -1.0 of L1-L4, and/or total femur or femoral neck, and gait speed (10-meter walk test (10MWT)) <= 1 (m/s2). The 12-week supervised EBRT was designed to train all major muscle groups for 3 times per week. In the first two sessions, the participants became familiar with targeted number of repetitions (TNRs) and OMNI-resistance exercise scale (OMNI-RES) to control exercise intensity. Following an adaptation phase of 4 weeks (1 set of 12 rep) using low resistance (yellow Thera-Band), exercise intensity progressively increased by adapting the resistance of the elastic band (based on the Thera-Band R force-elongation table) from yellow to red and further to black. The participants in the control group also received telephone contacts or face-to-face interviews on a weekly basis to maintain their typical diet and activity habits. A two-way repeated measures ANOVA was employed to determine the main changes (2 timesx2 groups) after 12 weeks of training. Partial eta-squared (etap2) was additionally used to determine ES in ANOVA tests. At all the stages of data analysis in this RCT, intention-to-treat (ITT) analysis was performed. The results of two-way ANOVA showed significant elevations in E2 (F = 7.881, p = 0.006, ES = 0.079), MQ (F = 4.225, p = 0.043, ES = 0.044), OSO Z-score (F = 7.091, p = 0.030, ES = 0.069), 30-s chair stand test (F = 4.599, p = 0.036, ES = 0.063) and hand grip strength (F = 6.411, p = 0.013, ES = 0.065) in the experimental group compared with those in the controls. Besides, there were no significant differences in CAF (F = 0.456, p = 0.501, ES = 0.005), CTX-I (F = 3.427, p = 0.067, ES = 0.036), adiponectin (F = 2.733, p = 0.102, ES = 0.029), sTnT (F = 3.245, p = 0.075, ES = 0.034), sclerostin (F = 2.927, p = 0.091, ES = 0.034), gait speed (10MWT) (F = 1.524, p = 0.220, ES = 0.016), 6MWT (F = 1.169, p = 0.284, ES = 0.017) and TUG (F = 1.502, p = 0.225, ES = 0.022), BMI (F = 0.354, p = 0.553, ES = 0.004), BFP (F = 2.888, p = 0.093, ES = 0.030), body mass content (BMC) (F = 0.030, p = 0.862, ES = 0.001) and BMD (F = 0.335, p = 0.564, ES = 0.004) between study groups. Taken together, the results of this study illustrated significant differences only in some OSO markers between groups after 48 h of chronic EBRT in women affected with OSO syndrome. Further research is thus recommended to design machine-based and elastic band-based training regimes at different intensities and volumes. Copyright © 2020. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.exger.2020.110884
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Banitalebi&issn=0531-5565&title=Experimental+Gerontology&atitle=Osteosarcopenic+obesity+markers+following+elastic+band+resistance+training%3A+A+randomized+controlled+trial.&volume=135&issue=&spage=110884&epage=&date=2020&doi=10.1016%2Fj.exger.2020.110884&pmid=32092502&sid=OVID:medline
+
+<1435>
+Unique Identifier
+ 32089876
+Title
+ Elevated Serum TNF-alpha Is Related to Obesity in Type 2 Diabetes Mellitus and Is Associated with Glycemic Control and Insulin Resistance.
+Source
+ Journal of Obesity. 2020:5076858, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alzamil H
+Author NameID
+ Alzamil, Hana; ORCID: https://orcid.org/0000-0002-9166-8297
+Authors Full Name
+ Alzamil, Hana.
+Institution
+ Alzamil, Hana. Physiology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2
+ Female
+ Glycemic Control
+ Humans
+ Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity
+ *Tumor Necrosis Factor-alpha/bl [Blood]
+Abstract
+ Background: Diabetes and obesity are very common associated metabolic disorders that are linked to chronic inflammation. Leptin is one of the important adipokines released from adipocytes, and its level increases with increasing body mass index (BMI). Tumor necrosis factor alpha (TNF-alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF-alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF-Methodology. This is a cross-sectional study involving 63 healthy volunteers and 65 patients with T2DM. Body composition was measured, and fasting venous blood samples were analyzed for blood glucose, glycosylated hemoglobin (HbA1c), basal insulin, leptin, and TNF-alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF-alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF.
+
+ Results: Our study showed a significantly higher level of TNF-alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF-p=0.008). In obese diabetic patients, the serum level of TNF-alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF-p=0.008). In obese diabetic patients, the serum level of TNF-p=0.008). In obese diabetic patients, the serum level of TNF-alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF-r = 0.361, p=0.008). In obese diabetic patients, the serum level of TNF-r = 0.361, p=0.008). In obese diabetic patients, the serum level of TNF.
+
+ Conclusion: TNF-alpha is associated with concurrent obesity and T2DM and correlates with HbA1c. This suggests that TNF-alpha needs further investigation to explore if it has a role in monitoring the effectiveness of management in individuals with obesity and T2DM. alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF-alpha) is a cytokine that is released by adipocytes and inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. The current study aims to investigate the involvement of leptin and TNF. Copyright © 2020 Hana Alzamil.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1155%2f2020%2f5076858
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alzamil&issn=2090-0708&title=Journal+of+Obesity&atitle=Elevated+Serum+TNF-alpha+Is+Related+to+Obesity+in+Type+2+Diabetes+Mellitus+and+Is+Associated+with+Glycemic+Control+and+Insulin+Resistance.&volume=2020&issue=&spage=5076858&epage=&date=2020&doi=10.1155%2F2020%2F5076858&pmid=32089876&sid=OVID:medline
+
+<1436>
+Unique Identifier
+ 32085704
+Title
+ The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents.
+Source
+ BMC Pediatrics. 20(1):81, 2020 02 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Varda NM; Medved M; Ojstersek L
+Author NameID
+ Varda, Natasa Marcun; ORCID: https://orcid.org/0000-0003-0634-3576
+Authors Full Name
+ Varda, Natasa Marcun; Medved, Martina; Ojstersek, Laura.
+Institution
+ Varda, Natasa Marcun. Department of Pediatrics, University Medical Center Maribor, Ljubljanska 5, 2000, Maribor, Slovenia. natasa.marcunvarda@amis.net.
+ Medved, Martina. University Medical Center Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia.
+ Ojstersek, Laura. University Medical Center Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ Body Mass Index
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases
+ Child
+ Heart Disease Risk Factors
+ Humans
+ Leptin
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Risk Factors
+ Slovenia/ep [Epidemiology]
+Keyword Heading
+ Adiponectin
+ Body mass index
+ Ghrelin
+ Hyperlipidemia
+ Hypertension
+ Leptin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: The occurrence of cardiovascular diseases and metabolic disorders steadily increases with the body mass index (BMI). Since the latter is not the best and earliest indicator of obesity and cardiovascular risk, the aim of the study was to evaluate some potential biological markers that would allow us to detect children and adolescents at higher risk at an early stage.
+
+ METHODS: A sample of 330 children and adolescents were included in the study and divided into four groups: obese patients with hypertension, normal-weight patients with hypertension, patients with mildly elevated lipids and a control group of healthy children and adolescents. Some clinical parameters (age, body weight, body height, BMI, waist circumference, hip circumference, blood pressure), biochemical parameters (glucose, total cholesterol, triglycerides, HDL, LDL, apolipoprotein A1, homocysteine) and biological markers of obesity (ghrelin, adiponectin, leptin) were evaluated.
+
+ RESULTS: Ghrelin and adiponectin were found to have a strong negative statistically significant correlation with BMI in all three observed groups (p < 0.001), but not in the control group (p = 0.053 and p = 0.316, respectively). In addition, leptin had a strong positive statistically significant correlation with BMI in all four groups (p < 0.001 for the research groups, p = 0.009 for the controls). In the group of obese patients with hypertension, statistically significant differences in all three markers of obesity were found in comparison to the control group (p < 0.001 for all markers). In the group of patients with mildly elevated lipids, ghrelin and leptin were significantly different (p = 0.002 and p < 0.001, respectively). In the group of normal-weight hypertensive patients, only values of ghrelin were different compared to the control group (p = 0.001).
+
+ CONCLUSION: In the research groups, significant differences were found in clinical, biochemical and biological parameters compared to the control group. The observed biological markers of obesity are useful early markers for identifying groups of patients that are at cardiovascular risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12887-020-1978-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Varda&issn=1471-2431&title=BMC+Pediatrics&atitle=The+associations+between+some+biological+markers%2C+obesity%2C+and+cardiovascular+risk+in+Slovenian+children+and+adolescents.&volume=20&issue=1&spage=81&epage=&date=2020&doi=10.1186%2Fs12887-020-1978-5&pmid=32085704&sid=OVID:medline
+
+<1437>
+Unique Identifier
+ 32076603
+Title
+ Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS.
+Source
+ BioMed Research International. 2020:1253164, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ He Y; Hu W; Yang G; Guo H; Liu H; Li L
+Author NameID
+ Li, Ling; ORCID: https://orcid.org/0000-0002-0087-3034
+Authors Full Name
+ He, Yirui; Hu, Wenjin; Yang, Gangyi; Guo, Huilin; Liu, Hua; Li, Ling.
+Institution
+ He, Yirui. Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
+ He, Yirui. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
+ Hu, Wenjin. Chongqing Prevention and Treatment Hospital for Occupational Diseases, Chongqing 400000, China.
+ Yang, Gangyi. Chongqing Prevention and Treatment Hospital for Occupational Diseases, Chongqing 400000, China.
+ Guo, Huilin. Chongqing Prevention and Treatment Hospital for Occupational Diseases, Chongqing 400000, China.
+ Liu, Hua. Department of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA.
+ Li, Ling. Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adiposity
+ Adolescent
+ Adult
+ Angiopoietin-Like Protein 8
+ Angiopoietin-like Proteins/bl [Blood]
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ Body Mass Index
+ Child
+ Child, Preschool
+ Cross-Sectional Studies
+ Fasting
+ Female
+ Glucose Clamp Technique
+ Humans
+ Infant
+ Infant, Newborn
+ Insulin
+ *Insulin Resistance
+ *Obesity/co [Complications]
+ Peptide Hormones/bl [Blood]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ *Polycystic Ovary Syndrome/et [Etiology]
+ Young Adult
+Abstract
+ The role of IR and metabolic disorders has become a crucial topic of study in the pathogenesis of PCOS. Adipose tissue is an important target organ of insulin, and adipose IR plays an important role in the occurrence and development of PCOS. This study seeks to investigate the role of adipose IR in the development of PCOS and to examine its relationship with circulating betatrophin levels in women with PCOS. A cross-sectional analysis of a cohort of women with PCOS and healthy women was performed in this study. Serum betatrophin concentrations were measured by ELISA. Adipose IR was calculated using the product of fasting insulin and FFA concentrations, and the relationship between adipose IR, circulating betatrophin, and other parameters was analyzed. Adipose IR in women with PCOS was significantly higher than that in controls. We found that women with PCOS who have adipose IR (adipose IR >= 55) have a higher BMI and higher blood glucose, insulin, PRL, FFA, TG, HOMA-IR, AUCglucose, AUCinsulin, VAIfemale, and BAI levels than PCOS-afflicted women without adipose IR, while M-values, and SHBG and LH levels were lower. In women with PCOS, serum betatrophin levels were significantly increased compared with controls. Adipose IR negatively correlated with M values and positively with circulating betatrophin levels in the study population. After metformin treatment, circulating betatrophin levels and adipose IR in women with PCOS were significantly decreased compared with pretreatment. Adipose IR is associated with betatrophin levels in women with PCOS. The combination of adipose IR and circulating betatrophin measurements may be significant for screening patients with PCOS. Copyright © 2020 Yirui He et al.
+Registry Number/Name of Substance
+ 0 (ANGPTL8 protein, human). 0 (Angiopoietin-Like Protein 8). 0 (Angiopoietin-like Proteins). 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Peptide Hormones).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1155%2f2020%2f1253164
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=He&issn=2314-6141&title=BioMed+Research+International&atitle=Adipose+Insulin+Resistance+and+Circulating+Betatrophin+Levels+in+Women+with+PCOS.&volume=2020&issue=&spage=1253164&epage=&date=2020&doi=10.1155%2F2020%2F1253164&pmid=32076603&sid=OVID:medline
+
+<1438>
+Unique Identifier
+ 32070346
+Title
+ Empagliflozin improved systolic blood pressure, endothelial dysfunction and heart remodeling in the metabolic syndrome ZSF1 rat.
+Source
+ Cardiovascular Diabetology. 19(1):19, 2020 02 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Park SH; Farooq MA; Gaertner S; Bruckert C; Qureshi AW; Lee HH; Benrahla D; Pollet B; Stephan D; Ohlmann P; Lessinger JM; Mayoux E; Auger C; Morel O; Schini-Kerth VB
+Authors Full Name
+ Park, Sin-Hee; Farooq, Muhammad Akmal; Gaertner, Sebastien; Bruckert, Christophe; Qureshi, Abdul Wahid; Lee, Hyun-Ho; Benrahla, Djamel; Pollet, Brigitte; Stephan, Dominique; Ohlmann, Patrick; Lessinger, Jean-Marc; Mayoux, Eric; Auger, Cyril; Morel, Olivier; Schini-Kerth, Valerie B.
+Institution
+ Park, Sin-Hee. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Farooq, Muhammad Akmal. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Gaertner, Sebastien. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Gaertner, Sebastien. Hopitaux Universitaires de Strasbourg, Service des Maladies Vasculaires - Hypertension Arterielle, Strasbourg, France.
+ Bruckert, Christophe. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Qureshi, Abdul Wahid. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Lee, Hyun-Ho. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Benrahla, Djamel. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Pollet, Brigitte. UMR CNRS 7021 Laboratoire de Bioimagerie et Pathologies, Strasbourg, France.
+ Stephan, Dominique. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Stephan, Dominique. Hopitaux Universitaires de Strasbourg, Service des Maladies Vasculaires - Hypertension Arterielle, Strasbourg, France.
+ Ohlmann, Patrick. Hopitaux Universitaires de Strasbourg, Service de Cardiologie, Strasbourg, France.
+ Lessinger, Jean-Marc. Laboratory of Biochemistry and Molecular Biology, Hopitaux Universitaires de Strasbourg, Strasbourg, France.
+ Mayoux, Eric. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
+ Auger, Cyril. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Morel, Olivier. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
+ Morel, Olivier. Hopitaux Universitaires de Strasbourg, Service de Cardiologie, Strasbourg, France.
+ Schini-Kerth, Valerie B. INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France. valerie.schini-kerth@unistra.fr.
+MeSH Subject Headings
+ Animals
+ *Benzhydryl Compounds/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Blood Pressure/de [Drug Effects]
+ Cellular Senescence/de [Drug Effects]
+ Disease Models, Animal
+ *Endothelium, Vascular/de [Drug Effects]
+ Endothelium, Vascular/me [Metabolism]
+ Endothelium, Vascular/pp [Physiopathology]
+ *Glucosides/pd [Pharmacology]
+ *Metabolic Syndrome/dt [Drug Therapy]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/co [Complications]
+ Rats, Zucker
+ *Sodium-Glucose Transporter 2 Inhibitors/pd [Pharmacology]
+ Systole
+ *Ventricular Function, Left/de [Drug Effects]
+ *Ventricular Remodeling/de [Drug Effects]
+Keyword Heading
+ Empagliflozin
+ Endothelial function
+ Heart function
+ Heart structure
+ Metabolic syndrome
+ SGLT2
+ Senescence
+ ZSF1
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Empagliflozin (empa), a selective sodium-glucose cotransporter (SGLT)2 inhibitor, reduced cardiovascular mortality and hospitalization for heart failure in patients with type 2 diabetes at high cardiovascular risk independent of glycemic control. The cardiovascular protective effect of empa was evaluated in an experimental model of metabolic syndrome, the obese ZSF1 rat, and its' lean control.
+
+ METHODS: Lean and obese ZSF1 rats were either non-treated or treated with empa (30 mg/kg/day) for 6 weeks. Vascular reactivity was assessed using mesenteric artery rings, systolic blood pressure by tail-cuff sphygmomanometry, heart function and structural changes by echocardiography, and protein expression levels by Western blot analysis.
+
+ RESULTS: Empa treatment reduced blood glucose levels from 275 to 196 mg/dl in obese ZSF1 rats whereas normoglycemia (134 mg/dl) was present in control lean ZSF1 rats and was unaffected by empa. Obese ZSF1 rats showed increased systolic blood pressure, and blunted endothelium-dependent relaxations associated with the appearance of endothelium-dependent contractile responses (EDCFs) compared to control lean rats. These effects were prevented by the empa treatment. Obese ZSF1 rats showed increased weight of the heart and of the left ventricle volume without the presence of diastolic or systolic dysfunction, which were improved by the empa treatment. An increased expression level of senescence markers (p53, p21, p16), tissue factor, VCAM-1, SGLT1 and SGLT2 and a down-regulation of eNOS were observed in the aortic inner curvature compared to the outer one in the control lean rats, which were prevented by the empa treatment. In the obese ZSF1 rats, no such effects were observed. The empa treatment reduced the increased body weight and weight of lungs, spleen, liver and perirenal fat, hyperglycemia and the increased levels of total cholesterol and triglycerides in obese ZSF1 rats, and increased blood ketone levels and urinary glucose excretion in control lean and obese ZSF1 rats.
+
+ CONCLUSION: Empa reduced glucose levels by 28% and improved both endothelial function and cardiac remodeling in the obese ZSF1 rat. Empa also reduced the increased expression level of senescence, and atherothrombotic markers at arterial sites at risk in the control lean, but not obese, ZSF1 rat.
+Registry Number/Name of Substance
+ 0 (Benzhydryl Compounds). 0 (Biomarkers). 0 (Blood Glucose). 0 (Glucosides). 0 (Sodium-Glucose Transporter 2 Inhibitors). HDC1R2M35U (empagliflozin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12933-020-00997-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Park&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Empagliflozin+improved+systolic+blood+pressure%2C+endothelial+dysfunction+and+heart+remodeling+in+the+metabolic+syndrome+ZSF1+rat.&volume=19&issue=1&spage=19&epage=&date=2020&doi=10.1186%2Fs12933-020-00997-7&pmid=32070346&sid=OVID:medline
+
+<1439>
+Unique Identifier
+ 32069846
+Title
+ Enhanced GIP Secretion in Obesity Is Associated with Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis.
+Source
+ Nutrients. 12(2), 2020 Feb 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Goralska J; Razny U; Polus A; Dziewonska A; Gruca A; Zdzienicka A; Dembinska-Kiec A; Solnica B; Micek A; Kapusta M; Slowinska-Solnica K; Malczewska-Malec M
+Author NameID
+ Goralska, Joanna; ORCID: https://orcid.org/0000-0002-9557-8440
+ Micek, Agnieszka; ORCID: https://orcid.org/0000-0001-8557-1774
+Authors Full Name
+ Goralska, Joanna; Razny, Urszula; Polus, Anna; Dziewonska, Agnieszka; Gruca, Anna; Zdzienicka, Anna; Dembinska-Kiec, Aldona; Solnica, Bogdan; Micek, Agnieszka; Kapusta, Maria; Slowinska-Solnica, Krystyna; Malczewska-Malec, Malgorzata.
+Institution
+ Goralska, Joanna. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Razny, Urszula. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Polus, Anna. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Dziewonska, Agnieszka. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Gruca, Anna. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Zdzienicka, Anna. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Dembinska-Kiec, Aldona. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Solnica, Bogdan. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Micek, Agnieszka. Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, Kopernika Str. 25, 31-501 Krakow, Poland.
+ Kapusta, Maria. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Slowinska-Solnica, Krystyna. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+ Malczewska-Malec, Malgorzata. Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika Str. 15A, 31-501 Krakow, Poland.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Epigenesis, Genetic
+ Fasting/bl [Blood]
+ Fatty Acids/bl [Blood]
+ *Fatty Liver/bl [Blood]
+ Fatty Liver/et [Etiology]
+ Fatty Liver/ge [Genetics]
+ Female
+ Fibroblast Growth Factors/bl [Blood]
+ *Gastric Inhibitory Polypeptide/bl [Blood]
+ Humans
+ Insulin/bl [Blood]
+ Liver/pa [Pathology]
+ Male
+ *MicroRNAs/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Odds Ratio
+ Postprandial Period
+ Signal Transduction/ge [Genetics]
+Keyword Heading
+ FGF-19
+ FGF-21
+ GIP
+ cytokeratin-18
+ gut-liver cross-talk
+ liver steatosis
+ miRNA
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Nutrient excess enhances glucose-dependent insulinotropic polypeptide (GIP) secretion, which may in turn contribute to the development of liver steatosis. We hypothesized that elevated GIP levels in obesity may affect markers of liver injury through microRNAs. The study involved 128 subjects (body mass index (BMI) 25-40). Fasting and postprandial GIP, glucose, insulin, and lipids, as well as fasting alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), cytokeratin-18, fibroblast growth factor (FGF)-19, and FGF-21 were determined. TaqMan low density array was used for quantitative analysis of blood microRNAs. Fasting GIP was associated with ALT [beta = 0.16 (confidence interval (CI): 0.01-0.32)], triglycerides [beta = 0.21 (95% CI: 0.06-0.36], and FGF-21 [beta = 0.20 (95%CI: 0.03-0.37)]; and postprandial GIP with GGT [beta = 0.17 (95%CI: 0.03-0.32)]. The odds ratio for elevated fatty liver index (>73%) was 2.42 (95%CI: 1.02-5.72) for high GIP versus low GIP patients. The miRNAs profile related to a high GIP plasma level included upregulated miR-136-5p, miR-320a, miR-483-5p, miR-520d-5p, miR-520b, miR-30e-3p, and miR-571. Analysis of the interactions of these microRNAs with gene expression pathways suggests their potential contribution to the regulation of the activity of genes associated with insulin resistance, fatty acids metabolism, and adipocytokines signaling. Exaggerated fasting and postprandial secretion of GIP in obesity are associated with elevated liver damage markers as well as FGF-21 plasma levels. Differentially expressed microRNAs suggest additional, epigenetic factors contributing to the gut-liver cross-talk.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Fatty Acids). 0 (Insulin). 0 (MicroRNAs). 0 (fibroblast growth factor 21). 59392-49-3 (Gastric Inhibitory Polypeptide). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12020476
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Goralska&issn=2072-6643&title=Nutrients&atitle=Enhanced+GIP+Secretion+in+Obesity+Is+Associated+with+Biochemical+Alteration+and+miRNA+Contribution+to+the+Development+of+Liver+Steatosis.&volume=12&issue=2&spage=&epage=&date=2020&doi=10.3390%2Fnu12020476&pmid=32069846&sid=OVID:medline
+
+<1440>
+Unique Identifier
+ 32069304
+Title
+ Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging.
+Source
+ PLoS ONE [Electronic Resource]. 15(2):e0229152, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Campolo J; Corradi E; Rizzardi A; Parolini M; Dellanoce C; Di Guglielmo ML; Tarlarini P; Cattaneo M; Trivella MG; De Maria R
+Author NameID
+ Campolo, Jonica; ORCID: https://orcid.org/0000-0002-1711-6216
+Authors Full Name
+ Campolo, Jonica; Corradi, Ettore; Rizzardi, Alice; Parolini, Marina; Dellanoce, Cinzia; Di Guglielmo, Maria Luisa; Tarlarini, Patrizia; Cattaneo, Marina; Trivella, Maria Giovanna; De Maria, Renata.
+Institution
+ Campolo, Jonica. CardioThoracic and Vascular Department, CNR Institute of Clinical Physiology, Milan, Italy.
+ Corradi, Ettore. Clinical Nutritional Unit, Medical Department, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
+ Rizzardi, Alice. CardioThoracic and Vascular Department, CNR Institute of Clinical Physiology, Milan, Italy.
+ Parolini, Marina. CardioThoracic and Vascular Department, CNR Institute of Clinical Physiology, Milan, Italy.
+ Dellanoce, Cinzia. CardioThoracic and Vascular Department, CNR Institute of Clinical Physiology, Milan, Italy.
+ Di Guglielmo, Maria Luisa. CardioThoracic and Vascular Department, CNR Institute of Clinical Physiology, Milan, Italy.
+ Tarlarini, Patrizia. Clinical Nutritional Unit, Medical Department, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
+ Cattaneo, Marina. Clinical Nutritional Unit, Medical Department, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
+ Trivella, Maria Giovanna. CardioThoracic and Vascular Department, CNR Institute of Clinical Physiology, Milan, Italy.
+ De Maria, Renata. CardioThoracic and Vascular Department, CNR Institute of Clinical Physiology, Milan, Italy.
+MeSH Subject Headings
+ Aged
+ Aging/bl [Blood]
+ *Aging/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Exercise
+ Female
+ *Fibronectins/me [Metabolism]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Sex Characteristics
+ *White People
+Abstract
+ Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic Caucasian subjects with stage I-II obesity in the early aging range (50 to 70 years), the relationship between irisin, body composition and markers of metabolic derangement by gender. In 60 (31 women, 29 men) non-diabetics with a body mass index >=30 - <=40 kg/m2, we measured anthropometrics and body composition (Air Displacement Plethysmography). We assayed lipid and glucose profile by routine methods, plasma irisin by ELISA and measured insulin resistance by the HOMA index. Irisin levels were higher in women than in men (161 [105-198]) vs 83 [33-115] ng/ml, P<0.001), and correlated directly with HOMA index in both (rho 0.735, P<0.001 M, rho 0.452, P = 0.011 F). Sex differences were maintained across insulin resistance severity stages. In men, irisin concentrations correlated directly with body mass index (rho 0.755, P<0.001), waist circumference (rho 0.623, P<0.001), fat mass index (rho 0.762, P<0.001), glucose (rho 0.408, P = 0.028), the fatty liver index (rho 0.705, P<0.001) and FINDRISC score (rho 0.536, P = 0.003). Among non-diabetic Caucasian subjects with obesity in the early stages of aging, irisin levels reflect the amount of body fat and insulin resistance severity, independently of between-gender differences in the adipomyokine concentrations and are associated with markers of visceral adiposity in men but not in women.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FNDC5 protein, human). 0 (Fibronectins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1371%2fjournal.pone.0229152
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Campolo&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Irisin+and+markers+of+metabolic+derangement+in+non-diabetic+Caucasian+subjects+with+stage+I-II+obesity+during+early+aging.&volume=15&issue=2&spage=e0229152&epage=&date=2020&doi=10.1371%2Fjournal.pone.0229152&pmid=32069304&sid=OVID:medline
+
+<1441>
+Unique Identifier
+ 32063406
+Title
+ Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome.
+Source
+ Clinical Nutrition. 39(10):3092-3098, 2020 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fuentes GC; Castaner O; Warnberg J; Subirana I; Buil-Cosiales P; Salas-Salvado J; Corella D; Serra-Majem L; Romaguera D; Estruch R; Martinez JA; Pinto X; Vazquez C; Vidal J; Tur JA; Aros F; Bullo M; Fito M; Schroder H
+Authors Full Name
+ Fuentes, Gabriela Cardenas; Castaner, Olga; Warnberg, Julia; Subirana, Isaac; Buil-Cosiales, Pilar; Salas-Salvado, Jordi; Corella, Dolores; Serra-Majem, Lluis; Romaguera, Dora; Estruch, Ramon; Martinez, J Alfredo; Pinto, Xavier; Vazquez, Clotilde; Vidal, Josep; Tur, Josep A; Aros, Fernando; Bullo, Monica; Fito, Montserrat; Schroder, Helmut.
+Institution
+ Fuentes, Gabriela Cardenas. Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; Biomedicine Program, Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain.
+ Castaner, Olga. Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Warnberg, Julia. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Nursing, School of Health Sciences. University of Malaga, Malaga, Spain.
+ Subirana, Isaac. Cardiovascular Epidemiology and Genetics Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
+ Buil-Cosiales, Pilar. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Navarra-Navarra Institute for Health Research, Pamplona, Spain; Primary Health Care Services-Osasunbidea, Pamplona, Navarra, Spain.
+ Salas-Salvado, Jordi. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Human Nutrition Unit, University Hospital of Sant Joan de Reus Department of Biochemistry and Biotechnology, Pere Virgili Institute for Health Research, Rovira i Virgili University, Reus, Spain.
+ Corella, Dolores. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine, University of Valencia, Valencia, Spain.
+ Serra-Majem, Lluis. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
+ Romaguera, Dora. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigacion Sanitaria Illes Balears (IdISBa), University Hospital of Son Espases, Palma de Mallorca, Spain.
+ Estruch, Ramon. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Internal Medicine, Hospital Clinic, IDIBAPS August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spain.
+ Martinez, J Alfredo. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain, Madrid Institute for Advanced Studies (IMDEA) Food Institute, Madrid, Spain.
+ Pinto, Xavier. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Lipid Unit, Department of Internal Medicine, Bellvitge Biomedical Research Institute (IDIBELL)-Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Vazquez, Clotilde. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology and Nutrition, University Hospital Fundacion Jimenez Diaz, Madrid, Spain.
+ Vidal, Josep. Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
+ Tur, Josep A. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, Palma de Mallorca, Spain.
+ Aros, Fernando. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; OSI ARABA. University Hospital Araba, Department of Cardiology University of the Basque Country UPV/EHU Vitoria-Gasteiz, Spain.
+ Bullo, Monica. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Biochemistry and Biotechnology, Human Nutrition Unit, Hospital Universitari Sant Joan de Reus, Reus, Spain.
+ Fito, Montserrat. Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: MFito@imim.es.
+ Schroder, Helmut. Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: hschroeder@imim.es.
+MeSH Subject Headings
+ Age Factors
+ Aged
+ Biomarkers/bl [Blood]
+ *Cytokines/bl [Blood]
+ Diet, Healthy
+ Diet, Mediterranean
+ *Exercise
+ Female
+ Health Knowledge, Attitudes, Practice
+ Humans
+ *Inflammation Mediators/bl [Blood]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/th [Therapy]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/th [Therapy]
+ Patient Education as Topic
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Spain/ep [Epidemiology]
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ Inflammation
+ Inflammatory score
+ Light physical activity
+ Moderate-to-vigorous physical activity
+ Prospective study
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are overweight or obese.
+
+ METHODS: This prospective study included 489 men and women, aged 55-75 years, from the PREDIMED-Plus trial. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES) were obtained from fasting blood samples and a composite inflammatory score based on these biomarkers was calculated. Physical activity was measured by a validated questionnaire. All measures were taken at baseline and one-year follow-up.
+
+ RESULTS: Multiple linear regression models showed an association between an increase in total PA and a decrease in the inflammatory score (p = 0.012), which was particularly driven by a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006).
+
+ CONCLUSIONS: Increases in total PA, moderate and moderate-to-vigorous PA were associated with a decrease in the inflammatory profile of obese or overweight older individuals. This finding is relevant for PA recommendations and public health strategies.
+
+ CLINICAL TRIAL REGISTRY: Clinical trial identifier: International Standard Randomized Controlled Trial 89898870. Copyright © 2020. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.clnu.2020.01.015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fuentes&issn=0261-5614&title=Clinical+Nutrition&atitle=Prospective+association+of+physical+activity+and+inflammatory+biomarkers+in+older+adults+from+the+PREDIMED-Plus+study+with+overweight+or+obesity+and+metabolic+syndrome.&volume=39&issue=10&spage=3092&epage=3098&date=2020&doi=10.1016%2Fj.clnu.2020.01.015&pmid=32063406&sid=OVID:medline
+
+<1442>
+Unique Identifier
+ 32063113
+Title
+ Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers.
+Source
+ Journal of the American Heart Association. 9(4):e013403, 2020 02 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chang YJ; Bellettiere J; Godbole S; Keshavarz S; Maestas JP; Unkart JT; Ervin D; Allison MA; Rock CL; Patterson RE; Jankowska MM; Kerr J; Natarajan L; Sears DD
+Authors Full Name
+ Chang, Ya-Ju; Bellettiere, John; Godbole, Suneeta; Keshavarz, Samaneh; Maestas, Joseph P; Unkart, Jonathan T; Ervin, Daniel; Allison, Matthew A; Rock, Cheryl L; Patterson, Ruth E; Jankowska, Marta M; Kerr, Jacqueline; Natarajan, Loki; Sears, Dorothy D.
+Institution
+ Chang, Ya-Ju. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Chang, Ya-Ju. Department of Medicine UC San Diego La Jolla CA.
+ Bellettiere, John. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Bellettiere, John. Center for Behavioral Epidemiology and Community Health San Diego State University San Diego CA.
+ Godbole, Suneeta. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Keshavarz, Samaneh. School of Medicine and Health Sciences The George Washington University Washington DC.
+ Maestas, Joseph P. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Unkart, Jonathan T. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Ervin, Daniel. Department of Research The East-West Center Honolulu HI.
+ Allison, Matthew A. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Rock, Cheryl L. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Rock, Cheryl L. Moores Cancer Center UC San Diego La Jolla CA.
+ Patterson, Ruth E. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Patterson, Ruth E. Moores Cancer Center UC San Diego La Jolla CA.
+ Jankowska, Marta M. Calit2/Qualcomm Institute UC San Diego La Jolla CA.
+ Kerr, Jacqueline. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Kerr, Jacqueline. Moores Cancer Center UC San Diego La Jolla CA.
+ Natarajan, Loki. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Natarajan, Loki. Moores Cancer Center UC San Diego La Jolla CA.
+ Sears, Dorothy D. Department of Family Medicine and Public Health UC San Diego La Jolla CA.
+ Sears, Dorothy D. Moores Cancer Center UC San Diego La Jolla CA.
+ Sears, Dorothy D. Department of Medicine UC San Diego La Jolla CA.
+ Sears, Dorothy D. College of Health Solutions Arizona State University Phoenix AZ.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ California/ep [Epidemiology]
+ Cardiometabolic Risk Factors
+ Cross-Sectional Studies
+ Female
+ *Hispanic or Latino
+ Humans
+ Insulin/bl [Blood]
+ Lipids/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/eh [Ethnology]
+ Postmenopause/bl [Blood]
+ *Postmenopause/eh [Ethnology]
+ Race Factors
+ Randomized Controlled Trials as Topic
+ Risk Assessment
+ *Sedentary Behavior/eh [Ethnology]
+ Sex Factors
+ *Sitting Position
+ Time Factors
+ Waist Circumference/eh [Ethnology]
+Keyword Heading
+ ActiGraph
+ Latina
+ cardiovascular risk
+ glucoregulatory
+ machine learning
+ type 2 diabetes
+ women's health
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Sedentary behavior is pervasive, especially in older adults, and is associated with cardiometabolic disease and mortality. Relationships between cardiometabolic biomarkers and sitting time are unexplored in older women, as are possible ethnic differences. Methods and Results Ethnic differences in sitting behavior and associations with cardiometabolic risk were explored in overweight/obese postmenopausal women (n=518; mean+/-SD age 63+/-6 years; mean body mass index 31.4+/-4.8 kg/m2). Accelerometer data were processed using validated machine-learned algorithms to measure total daily sitting time and mean sitting bout duration (an indicator of sitting behavior pattern). Multivariable linear regression was used to compare sitting among Hispanic women (n=102) and non-Hispanic women (n=416) and tested associations with cardiometabolic risk biomarkers. Hispanic women sat, on average, 50.3 minutes less/day than non-Hispanic women (P<0.001) and had shorter (3.6 minutes less, P=0.02) mean sitting bout duration. Among all women, longer total sitting time was deleteriously associated with fasting insulin and triglyceride concentrations, insulin resistance, body mass index and waist circumference; longer mean sitting bout duration was deleteriously associated with fasting glucose and insulin concentrations, insulin resistance, body mass index and waist circumference. Exploratory interaction analysis showed that the association between mean sitting bout duration and fasting glucose concentration was significantly stronger among Hispanic women than non-Hispanic women (P-interaction=0.03). Conclusions Ethnic differences in 2 objectively measured parameters of sitting behavior, as well as detrimental associations between parameters and cardiometabolic biomarkers were observed in overweight/obese older women. The detrimental association between mean sitting bout duration and fasting glucose may be greater in Hispanic women than in non-Hispanic women. Corroboration in larger studies is warranted.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Lipids).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1161%2fJAHA.119.013403
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chang&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Total+Sitting+Time+and+Sitting+Pattern+in+Postmenopausal+Women+Differ+by+Hispanic+Ethnicity+and+are+Associated+With+Cardiometabolic+Risk+Biomarkers.&volume=9&issue=4&spage=e013403&epage=&date=2020&doi=10.1161%2FJAHA.119.013403&pmid=32063113&sid=OVID:medline
+
+<1443>
+Unique Identifier
+ 32054279
+Title
+ A systematic review of cross-sectional studies on the association of sedentary behavior with cardiometabolic diseases and related biomarkers in South American adults.
+Original Title
+ Revision sistematica de estudios transversales sobre la asociacion de la conducta sedentaria con las enfermedades cardiometabolicas y sus biomarcadores relacionados en adultos sudamericanos.
+Source
+ Nutricion Hospitalaria. 37(2):359-373, 2020 Apr 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Marin KA; Hermsdorf HHM; Canaan Rezende FA; Peluzio MDCG; Natali AJ
+Authors Full Name
+ Marin, Kliver Antonio; Hermsdorf, Helen Hermana Miranda; Canaan Rezende, Fabiane Aparecida; Peluzio, Maria do Carmo Gouveia; Natali, Antonio Jose.
+Institution
+ Marin, Kliver Antonio. Universidade Federal do Tocantins.
+ Hermsdorf, Helen Hermana Miranda. Universidade Federal de Vicosa.
+ Canaan Rezende, Fabiane Aparecida. Universidade Federal do Tocantins.
+ Peluzio, Maria do Carmo Gouveia. Universidade Federal de Vicosa.
+ Natali, Antonio Jose. Universidade Federal de Vicosa.
+MeSH Subject Headings
+ Adult
+ *Biomarkers
+ *Cardiovascular Diseases
+ Cross-Sectional Studies
+ Diabetes Mellitus
+ Female
+ Humans
+ Hypertension
+ Male
+ Metabolic Syndrome
+ Obesity
+ *Sedentary Behavior
+ South America
+Keyword Heading
+ Obesidad. Diabetes mellitus. Hipertension. Indice de masa corporal. Sindrome metabolico.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Introduction: sedentary behavior (SB) has been independently associated with detrimental health outcomes in different regions worldwide. The aim of this systematic review was to examine whether domain-specific SB is associated with cardiometabolic diseases (CMD) and related biomarkers in South American adults. Methods: nine electronic databases were searched to identify all studies that analyzed the association between SB and CMD-e.g. obesity, diabetes, hypertension, metabolic syndrome (MetS) and clustering of chronic diseases (CCD)-and related biomarkers in South American adults. Two independent reviewers performed the necessary abstract/full-text screening, data abstraction, and quality assessments. The review protocol was registered in the PROSPERO database (CRD42018099319). Results: from the 1,262 articles identified in the search 262 were reviewed in full and 20 were used in the analysis in accordance to the inclusion criteria. High SB (mainly sitting and TV time) was associated with an increased likelihood of obesity (n = 8), diabetes (n = 6), and CCD (n = 3), as well as high values of BMI (n = 8), WC (n = 7), % BF (n = 4), plasma lipids (n = 4), and glycemia (n = 5). Eleven out of 20 studies were of higher quality. Conclusion : long time spent in SB, mainly sitting and TV time, was positively associated with the occurrence of CMD and related biomarkers in South American adults.
+Other Abstract
+ Publisher
+ INTRODUCCION: Introduccion: el comportamiento sedentario (CS) se ha asociado de forma independiente con resultados perjudiciales para la salud en diferentes regiones del mundo. El objetivo de esta revision sistematica fue examinar si el CS especifico de cada dominio se asocia o no a enfermedades cardiometabolicas (ECM) y sus biomarcadores relacionados en adultos sudamericanos. Metodos: se realizaron busquedas en nueve bases de datos electronicas para identificar todos los estudios que habian analizado la asociacion entre CS y ECM -por ejemplo, obesidad, diabetes, hipertension, sindrome metabolico y agrupacion de enfermedades cronicas (AEC)- y sus biomarcadores relacionados en adultos sudamericanos. Dos revisores independientes realizaron evaluaciones de los resumenes/textos completos, el resumen de los datos y evaluaciones de calidad. El protocolo de revision esta registrado en la base de datos PROSPERO (CRD42018099319). Resultados: de los 1262 articulos identificados en la busqueda, 262 se revisaron en su totalidad y 20 se utilizaron en el analisis de acuerdo con los criterios de inclusion. El gran CS (principalmente, tiempo sentado y de television) se asocio a una mayor probabilidad de obesidad (n = 8), diabetes (n = 6) y AEC (n = 3), asi como a valores altos de IMC (n = 8), WC (n = 7), % BF (n = 4), lipidos plasmaticos (n = 4) y glucemia (n = 5). Once de los 20 estudios fueron de alta calidad. Conclusion: la gran cantidad de tiempo invertido en el CS, principalmente el tiempo sentado y de television, se asocio positivamente con la aparicion de ECM y sus biomarcadores relacionados en adultos de America del Sur.
+ Language: Spanish
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.20960%2fnh.02740
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Marin&issn=0212-1611&title=Nutricion+Hospitalaria&atitle=Revision+sistematica+de+estudios+transversales+sobre+la+asociacion+de+la+conducta+sedentaria+con+las+enfermedades+cardiometabolicas+y+sus+biomarcadores+relacionados+en+adultos+sudamericanos.&volume=37&issue=2&spage=359&epage=373&date=2020&doi=10.20960%2Fnh.02740&pmid=32054279&sid=OVID:medline
+
+<1444>
+Unique Identifier
+ 32046640
+Title
+ Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study.
+Source
+ BMC Cardiovascular Disorders. 20(1):77, 2020 02 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pettersson-Pablo P; Cao Y; Backstrom T; Nilsson TK; Hurtig-Wennlof A
+Author NameID
+ Pettersson-Pablo, Paul; ORCID: https://orcid.org/0000-0001-8458-6448
+Authors Full Name
+ Pettersson-Pablo, Paul; Cao, Yang; Backstrom, Torbjorn; Nilsson, Torbjorn K; Hurtig-Wennlof, Anita.
+Institution
+ Pettersson-Pablo, Paul. Department of Laboratory Medicine, Faculty of Medicine and Health, Orebro University Hospital, Orebro, Sweden. paul.pettersson-pablo@regionorebrolan.se.
+ Pettersson-Pablo, Paul. School of Medicine, Faculty of Medicine and Health, Orebro University, Orebro, Sweden. paul.pettersson-pablo@regionorebrolan.se.
+ Pettersson-Pablo, Paul. Department of Medical Biosciences/Clinical Chemistry, Umea University, Umea, Sweden. paul.pettersson-pablo@regionorebrolan.se.
+ Cao, Yang. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Orebro University, Orebro, Sweden.
+ Backstrom, Torbjorn. Department of Clinical Science, Obstetrics and Gynecology, Umea University, Umea, Sweden.
+ Nilsson, Torbjorn K. Department of Medical Biosciences/Clinical Chemistry, Umea University, Umea, Sweden.
+ Hurtig-Wennlof, Anita. School of Health, Faculty of Medicine and Health, Orebro University, Orebro, Sweden.
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ Adult
+ Age Factors
+ Atherosclerosis/bl [Blood]
+ Atherosclerosis/di [Diagnosis]
+ *Atherosclerosis/et [Etiology]
+ Atherosclerosis/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ *C-Reactive Protein/an [Analysis]
+ Carotid Intima-Media Thickness
+ Cluster Analysis
+ Female
+ Health Status
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/co [Complications]
+ Inflammation/di [Diagnosis]
+ *Inflammation Mediators/bl [Blood]
+ Male
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ Pulse Wave Analysis
+ Risk Assessment
+ Risk Factors
+ Young Adult
+Keyword Heading
+ Atherosclerosis
+ Body fat percentage
+ CRP
+ Cardiovascular risk
+ Cluster analysis
+ Endothelial dysfunction
+ Obesity
+ Young adults
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Identification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy adults.
+
+ METHODS: Pulse-wave velocity (PWV), carotid-intima media thickness (cIMT) and augmentation index (AIX) were measured in 834 healthy non-smokers (ages 18.0-25.9). Emphasis was put on discriminating between individuals having a vascular structure and function associated with a higher or lower risk, and cluster analysis algorithms were employed to assign the subjects into groups based on these vascular measurements. In addition, a vascular status score (VSS) was calculated by summarizing the results according to quintiles of the vascular measurements. The associations between VSS and cardiovascular biomarkers were examined by regression analyses.
+
+ RESULTS: The cluster analyses did not yield sufficiently distinct clustering (groups of individuals that could be categorized unequivocally as having either a vascular structure and function associated with a higher or lower CVD risk). VSS proved a better classificatory variable. The associations between VSS and biomarkers of cardiovascular risk were analyzed by univariable and multivariable regressions. Only body fat percentage and C-reactive protein (CRP) were independently associated with VSS.
+
+ CONCLUSIONS: A VSS calculation, which integrates PWV, cIMT, and AIX measurements is better suited for cardiovascular risk evaluation in young adults than cluster analyses. The independent associations of VSS with body fat percentage and CRP highlight the decisive role of adiposity and systemic inflammation in early atherosclerotic progression and suggests a subordinate role of insulin and lipid metabolism in this age span.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12872-020-01376-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pettersson-Pablo&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Body+fat+percentage+and+CRP+correlates+with+a+composite+score+of+vascular+risk+markers+in+healthy%2C+young+adults+-+The+Lifestyle%2C+Biomarkers%2C+and+Atherosclerosis+%28LBA%29+study.&volume=20&issue=1&spage=77&epage=&date=2020&doi=10.1186%2Fs12872-020-01376-6&pmid=32046640&sid=OVID:medline
+
+<1445>
+Unique Identifier
+ 32044999
+Title
+ Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(4), 2020 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ghanim H; Abuaysheh S; Hejna J; Green K; Batra M; Makdissi A; Chaudhuri A; Dandona P
+Authors Full Name
+ Ghanim, Husam; Abuaysheh, Sanaa; Hejna, Jeanne; Green, Kelly; Batra, Manav; Makdissi, Antione; Chaudhuri, Ajay; Dandona, Paresh.
+Institution
+ Ghanim, Husam. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York.
+ Abuaysheh, Sanaa. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York.
+ Hejna, Jeanne. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York.
+ Green, Kelly. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York.
+ Batra, Manav. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York.
+ Makdissi, Antione. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York.
+ Chaudhuri, Ajay. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York.
+ Dandona, Paresh. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York.
+MeSH Subject Headings
+ Anti-Infective Agents/ch [Chemistry]
+ Anti-Infective Agents/tu [Therapeutic Use]
+ *Benzhydryl Compounds/tu [Therapeutic Use]
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Double-Blind Method
+ *Erythropoiesis/de [Drug Effects]
+ Female
+ Follow-Up Studies
+ *Glucosides/tu [Therapeutic Use]
+ Glycated Hemoglobin/an [Analysis]
+ Hepcidins/ai [Antagonists & Inhibitors]
+ *Hepcidins/tu [Therapeutic Use]
+ Humans
+ Hypoxia-Inducible Factor 1, alpha Subunit/me [Metabolism]
+ Hypoxia-Inducible Factor-Proline Dioxygenases/me [Metabolism]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Sodium-Glucose Transporter 2 Inhibitors/tu [Therapeutic Use]
+Keyword Heading
+ dapagliflozin
+ erythropoiesis
+ hepcidin
+ iron
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Dapagliflozin and other SGLT2 inhibitors are known to increase hematocrit, possibly due to its diuretic effects and hemoconcentration.
+
+ OBJECTIVE: Since type 2 diabetes is a proinflammatory state and since hepcidin, a known suppressor of erythropoiesis, is increased in proinflammatory states, we investigated the possibility that dapagliflozin suppresses hepcidin concentrations and thus increases erythropoiesis.
+
+ DESIGN: Prospective, randomized, and placebo-controlled study.
+
+ SETTING: Single endocrinology center.
+
+ PATIENTS: Fifty-two obese type 2 diabetes patients.
+
+ INTERVENTION: Patients were randomized (1:1) to either dapagliflozin (10 mg daily) or placebo for 12 weeks. Blood samples were collected before and after treatments and serum, plasma, and mononuclear cells (MNC) were prepared.
+
+ MAIN OUTCOME MEASURE: Hepcidin and other hematopoietic factors.
+
+ RESULTS: Following dapagliflozin treatment, there was a significant fall in HbA1c and a significant increase in hemoglobin concentration and hematocrit. Dapagliflozin treatment significantly reduced circulating hepcidin and ferritin concentrations while causing a significant increase in levels of the hepcidin inhibitor, erythroferrone, and a transient increase in erythropoietin. Additionally, dapagliflozin increased plasma transferrin levels and expression of transferrin receptors 1 and 2 in MNC, while there was no change in the expression of the iron cellular transporter, ferroportin. Dapagliflozin treatment also caused a decrease in hypoxia-induced factor-1alpha expression in MNC while it increased the expression of its inhibitor, prolyl hydroxylase-2. There were no significant changes in any of these indices in the placebo group.
+
+ CONCLUSIONS: We conclude that dapagliflozin increases erythropoiesis and hematocrit through mechanisms that involve the suppression of hepcidin and the modulation of other iron regulatory proteins. Copyright © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Anti-Infective Agents). 0 (Benzhydryl Compounds). 0 (Biomarkers). 0 (Blood Glucose). 0 (Glucosides). 0 (Glycated Hemoglobin A). 0 (HIF1A protein, human). 0 (Hepcidins). 0 (Hypoxia-Inducible Factor 1, alpha Subunit). 0 (Sodium-Glucose Transporter 2 Inhibitors). 0 (hemoglobin A1c protein, human). 1ULL0QJ8UC (dapagliflozin). EC 1-14-11-2 (EGLN1 protein, human). EC 1-14-11-29 (Hypoxia-Inducible Factor-Proline Dioxygenases).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1210%2fclinem%2fdgaa057
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ghanim&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Dapagliflozin+Suppresses+Hepcidin+And+Increases+Erythropoiesis.&volume=105&issue=4&spage=e1056&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgaa057&pmid=32044999&sid=OVID:medline
+
+<1446>
+Unique Identifier
+ 32041925
+Title
+ Characteristics of salivary inflammation in obesity.
+Source
+ Polish Archives Of Internal Medicine. 130(4):297-303, 2020 04 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lehmann AP; Nijakowski K; Swora-Cwynar E; Luczak J; Czepulis N; Surdacka A
+Authors Full Name
+ Lehmann, Anna P; Nijakowski, Kacper; Swora-Cwynar, Ewelina; Luczak, Joanna; Czepulis, Natasza; Surdacka, Anna.
+Institution
+ Lehmann, Anna P. Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Poznan, Poland. annalehmann@ump.edu.pl
+ Nijakowski, Kacper. Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Poznan, Poland
+ Swora-Cwynar, Ewelina. Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland
+ Luczak, Joanna. Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
+ Czepulis, Natasza. Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
+ Surdacka, Anna. Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Poznan, Poland
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers
+ Body Mass Index
+ Female
+ Humans
+ *Inflammation
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity
+ Saliva
+ Young Adult
+Abstract
+ INTRODUCTION: The discovery of the secretory function of adipose tissue has led to a new direction in research on obesity- related health problems. Adipokines are present not only in blood but also in saliva. Numerous studies have indicated that obesity affects salivary concentrations of adipokines.
+
+ OBJECTIVES: The aim of this study was to evaluate the levels of selected inflammatory markers in saliva and to determine their discriminatory value in obese individuals.
+
+ PATIENTS AND METHODS: The study included 125 patients (82 women and 43 men), aged from 20 to 65 years. There were 59 patients with obesity (body mass index [BMI] >30 kg/m2) and 66 controls with normal body weight (BMI <25 kg/m2). Mixed saliva samples were collected from all participants to determine the concentrations of the following inflammatory markers: tumor necrosis factor- alpha receptors 1 and 2, pentraxin 3, interleukin 15, monocyte chemoattractant protein 1, soluble intercellular adhesion molecule 1, and soluble CD40 ligand (sCD40L).
+
+ RESULTS: Compared with controls, individuals with obesity had significantly higher levels of all inflammatory markers except sCD40L levels, which were lower. The salivary marker sCD40L seems to have the best discriminatory value in obesity regardless of sex, with the optimal cutoff point of 3.28 pg/ml and the area under the curve of 0.8.
+
+ CONCLUSIONS: Obesity may be associated with altered levels of selected inflammatory markers in saliva. The discriminatory values determined in this study may facilitate the diagnosis of metabolic diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.20452%2fpamw.15186
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lehmann&issn=0032-3772&title=Polish+Archives+Of+Internal+Medicine&atitle=Characteristics+of+salivary+inflammation+in+obesity.&volume=130&issue=4&spage=297&epage=303&date=2020&doi=10.20452%2Fpamw.15186&pmid=32041925&sid=OVID:medline
+
+<1447>
+Unique Identifier
+ 32027700
+Title
+ Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk.
+Source
+ PLoS ONE [Electronic Resource]. 15(2):e0228633, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elisia I; Lam V; Cho B; Hay M; Li MY; Kapeluto J; Elliott T; Harris D; Bu L; Jia W; Leung H; Mohn W; Krystal G
+Author NameID
+ Krystal, Gerald; ORCID: https://orcid.org/0000-0002-1961-6281
+Authors Full Name
+ Elisia, Ingrid; Lam, Vivian; Cho, Brandon; Hay, Mariah; Li, Michael Yu; Kapeluto, Jordanna; Elliott, Tom; Harris, David; Bu, Luke; Jia, William; Leung, Hilary; Mohn, William; Krystal, Gerald.
+Institution
+ Elisia, Ingrid. The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
+ Lam, Vivian. The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
+ Cho, Brandon. The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
+ Hay, Mariah. The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
+ Li, Michael Yu. The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
+ Kapeluto, Jordanna. Department of Medicine, Division of Endocrinology, University of British Columbia, Vancouver, British Columbia, Canada.
+ Elliott, Tom. B.C Diabetes, Vancouver, British Columbia, Canada.
+ Harris, David. Richmond General Hospital Metabolic and Bariatric Surgery, Richmond, British Columbia, Canada.
+ Bu, Luke. Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
+ Jia, William. Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
+ Leung, Hilary. Microbiome Insights, Vancouver, British Columbia, Canada.
+ Mohn, William. Department of Microbiology & Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
+ Krystal, Gerald. The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Cells
+ Case-Control Studies
+ Cohort Studies
+ Female
+ Humans
+ Immunity
+ Inflammation
+ Male
+ Neoplasms/bl [Blood]
+ *Neoplasms/et [Etiology]
+ *Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Risk Assessment
+Abstract
+ Obesity has reached epidemic proportions and is often accompanied by elevated levels of pro-inflammatory cytokines that promote many chronic diseases, including cancer. However, not all obese people develop these diseases and it would be very helpful to identify those at high risk early on so that preventative measures can be instituted. We performed an extensive evaluation of the effects of obesity on inflammatory markers, on innate and adaptive immune responses, and on blood cell composition to identify markers that might be useful in distinguishing those at elevated risk of cancer. Plasma samples from 42 volunteers with a BMI>35 had significantly higher CRP, PGE2, IL-1RA, IL-6 and IL-17 levels than 34 volunteers with normal BMIs. Of the cytokines and chemokines tested, only IL-17 was significantly higher in men with a BMI>35 than women with a BMI>35. As well, only IL-17 was significantly higher in those with a BMI>35 that had type 2 diabetes versus those without type 2 diabetes. Whole blood samples from participants with a BMI>35, when challenged with E. coli, produced significantly higher levels of IL-1RA while HSV-1 challenge resulted in significantly elevated IL-1RA and VEGF, and a non-significant increase in G-CSF and IL-8 levels. T cell activation of PBMCs, via anti-CD3 plus anti-CD28, resulted in significantly higher IFNgamma production from volunteers with a BMI>35. In terms of blood cells, red blood cell distribution width (RDW), monocytes, granulocytes, CD4+T cells and Tregs were all significantly higher while, natural killer (NK) and CD8+ T cells were all significantly lower in the BMI>35 cohort, suggesting that obesity may reduce the ability to kill nascent tumor cells. Importantly, however, there was considerable person-to-person variation amongst participants with a BMI>35, with some volunteers showing markedly different values from controls and others showing normal levels of many parameters measured. These person-to-person variations may prove useful in identifying those at high risk of developing cancer.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1371%2fjournal.pone.0228633
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elisia&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Exploratory+examination+of+inflammation+state%2C+immune+response+and+blood+cell+composition+in+a+human+obese+cohort+to+identify+potential+markers+predicting+cancer+risk.&volume=15&issue=2&spage=e0228633&epage=&date=2020&doi=10.1371%2Fjournal.pone.0228633&pmid=32027700&sid=OVID:medline
+
+<1448>
+Unique Identifier
+ 32020371
+Title
+ Non-alcoholic Fatty Liver Disease and Its Links with Inflammation and Atherosclerosis. [Review]
+Source
+ Current Atherosclerosis Reports. 22(1):7, 2020 02 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abdallah LR; de Matos RC; E Souza YPDM; Vieira-Soares D; Muller-Machado G; Pollo-Flores P
+Authors Full Name
+ Abdallah, Luan Rodrigues; de Matos, Ricardo Cardoso; E Souza, Yves Pacheco Dias March; Vieira-Soares, Debora; Muller-Machado, Gabriela; Pollo-Flores, Priscila.
+Institution
+ Abdallah, Luan Rodrigues. Antonio-Pedro Universitary Hospital, 303 Marques de Parana, Center, Niteroi, Rio de Janeiro, Brazil.
+ de Matos, Ricardo Cardoso. Antonio-Pedro Universitary Hospital, 303 Marques de Parana, Center, Niteroi, Rio de Janeiro, Brazil.
+ E Souza, Yves Pacheco Dias March. Antonio-Pedro Universitary Hospital, 303 Marques de Parana, Center, Niteroi, Rio de Janeiro, Brazil.
+ Vieira-Soares, Debora. Antonio-Pedro Universitary Hospital, 303 Marques de Parana, Center, Niteroi, Rio de Janeiro, Brazil.
+ Muller-Machado, Gabriela. Antonio-Pedro Universitary Hospital, 303 Marques de Parana, Center, Niteroi, Rio de Janeiro, Brazil.
+ Pollo-Flores, Priscila. Antonio-Pedro Universitary Hospital, 303 Marques de Parana, Center, Niteroi, Rio de Janeiro, Brazil. priscilapolloflores@id.uff.br.
+MeSH Subject Headings
+ *Atherosclerosis/ep [Epidemiology]
+ Biomarkers
+ Comorbidity
+ *Coronary Artery Disease/ep [Epidemiology]
+ Humans
+ Inflammation/ep [Epidemiology]
+ *Metabolic Syndrome/ep [Epidemiology]
+ *Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Factors
+ *Vascular Calcification/ep [Epidemiology]
+ Vascular Stiffness
+Keyword Heading
+ Aortic stiffness
+ Atherosclerosis
+ Cardiovascular risks
+ Carotid media thickness
+ Coronary artery calcification
+ Inflammation
+ Non-alcoholic fatty liver disease
+ Steatohepatitis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE OF REVIEW: We summarize best data of the association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD).
+
+ RECENT FINDINGS: NAFLD has been linked with insulin resistance, obesity, and metabolic syndrome, conditions known to be associated with CVD and subclinical atherosclerosis. The rising evidence of the association between NAFLD and subclinical CVD may suggest that NAFLD is not only a marker but also may be actively involved in pathogenesis of CVD. It is an overview of previous studies assessing relationships between NAFLD and markers of cardiovascular disease, as the presence of coronary artery calcification, increased arterial stiffness, and elevated carotid media thickness, in order to better understand the interplay between these conditions.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs11883-020-0820-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abdallah&issn=1523-3804&title=Current+Atherosclerosis+Reports&atitle=Non-alcoholic+Fatty+Liver+Disease+and+Its+Links+with+Inflammation+and+Atherosclerosis.&volume=22&issue=1&spage=7&epage=&date=2020&doi=10.1007%2Fs11883-020-0820-8&pmid=32020371&sid=OVID:medline
+
+<1449>
+Unique Identifier
+ 32017477
+Title
+ Non-standard AGE4 epitopes that predict polyneuropathy independently of obesity can be detected by slot dot-blot immunoassay.
+Source
+ Advances in Clinical & Experimental Medicine. 29(1):91-100, 2020 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bronowicka-Szydelko A; Krzystek-Korpacka M; Kuzan A; Gostomska-Pampuch K; Gacka M; Jakobsche-Policht U; Adamiec R; Gamian A
+Authors Full Name
+ Bronowicka-Szydelko, Agnieszka; Krzystek-Korpacka, Malgorzata; Kuzan, Aleksandra; Gostomska-Pampuch, Kinga; Gacka, Malgorzata; Jakobsche-Policht, Urszula; Adamiec, Rajmund; Gamian, Andrzej.
+Institution
+ Bronowicka-Szydelko, Agnieszka. Department of Medical Biochemistry, Wroclaw Medical University, Poland.
+ Krzystek-Korpacka, Malgorzata. Department of Medical Biochemistry, Wroclaw Medical University, Poland.
+ Kuzan, Aleksandra. Department of Medical Biochemistry, Wroclaw Medical University, Poland.
+ Gostomska-Pampuch, Kinga. Department of Medical Biochemistry, Wroclaw Medical University, Poland.
+ Gostomska-Pampuch, Kinga. Laboratory of Medical Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
+ Gacka, Malgorzata. Department of Angiology, Diabetes and Hypertension, Wroclaw Medical University, Poland.
+ Jakobsche-Policht, Urszula. Department of Angiology, Diabetes and Hypertension, Wroclaw Medical University, Poland.
+ Adamiec, Rajmund. Department of Angiology, Diabetes and Hypertension, Wroclaw Medical University, Poland.
+ Gamian, Andrzej. Department of Medical Biochemistry, Wroclaw Medical University, Poland.
+ Gamian, Andrzej. Laboratory of Medical Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Enzyme-Linked Immunosorbent Assay
+ *Epitopes
+ Glycation End Products, Advanced/bl [Blood]
+ Glycation End Products, Advanced/ge [Genetics]
+ *Glycation End Products, Advanced
+ Humans
+ Immunoassay
+ Obesity/ge [Genetics]
+ *Obesity
+ Polyneuropathies/ge [Genetics]
+ *Polyneuropathies
+Keyword Heading
+ ELISA
+ advanced glycation end-products (AGEs)
+ diabetes
+ methylglyoxal
+ slot dot-blot
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Advanced glycation end-products (AGEs) are formed during cascade reactions between reducing sugars or reactive aldehydes and proteins, lipids or DNA molecules. They constitute a group of various stable compounds. Advanced glycation end-products are considered potential biomarkers of metabolic disorders. However, so far only a few methods to determine the level of individual AGEs have been developed.
+
+ OBJECTIVES: The aim of the study was to compare the efficiency of the slot-dot blot method and direct enzyme-linked immunosorbent assay (ELISA) in detecting non-standard epitopes of methylglyoxal (MGO)-modified proteins (AGE4) found in diabetes serum in trace amounts, and to assess AGE4 in diabetes and associated metabolic abnormalities.
+
+ MATERIAL AND METHODS: The presence of AGE4 was detected using 2 methods: direct ELISA and the slot-dot blot method - a newly developed immunoassay based on monoclonal, commercially available antibody detection of non-standard AGE epitopes. AGE4 quantification, expressed as median AGE4 in arbitrary units (AU) and AGE4 positivity (the percent of samples with detectable AGE4) was related to diabetes-associated metabolic abnormalities, complications and treatment.
+
+ RESULTS: Slot-dot blot was significantly more efficient than ELISA in detecting non-standard AGE4 epitopes. AGE4 positivity was less frequent in patients with microangiopathy and in those with polyneuropathy. In patients with abnormal glucose metabolism, metformin treatment was associated with higher AGE4. AGE4 positivity was significantly lower in gliptin-treated patients. Multivariate analysis showed that polyneuropathy and obesity were independently associated with AGE4 positivity, with odds ratios (ORs) of 0.21 and 3.02, respectively. Moreover, logistic regression showed that AGE4 positivity and HbA1c are independent predictors of polyneuropathy. Considering both indicators allows correct classification of 70.4% of cases with a general accuracy of 76%.
+
+ CONCLUSIONS: The slot dot-blot method detects compounds found in serum in trace amounts. Accumulation of AGE4 was associated with glucose metabolism abnormalities. A tendency toward AGE4 positivity was less frequent in patients with microangiopathy and in non-treated and gliptin-treated diabetes patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Epitopes). 0 (Glycation End Products, Advanced).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.17219%2facem%2f112612
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bronowicka-Szydelko&issn=1899-5276&title=Advances+in+Clinical+%26+Experimental+Medicine&atitle=Non-standard+AGE4+epitopes+that+predict+polyneuropathy+independently+of+obesity+can+be+detected+by+slot+dot-blot+immunoassay.&volume=29&issue=1&spage=91&epage=100&date=2020&doi=10.17219%2Facem%2F112612&pmid=32017477&sid=OVID:medline
+
+<1450>
+Unique Identifier
+ 32017362
+Title
+ Different beta-cell secretory phenotype in non-obese compared to obese early type 2 diabetes.
+Source
+ Diabetes/Metabolism Research Reviews. 36(5):e3295, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gudipaty L; Rosenfeld NK; Fuller CS; Cuchel M; Rickels MR
+Author NameID
+ Rickels, Michael R; ORCID: https://orcid.org/0000-0002-9253-838X
+Authors Full Name
+ Gudipaty, Lalitha; Rosenfeld, Nora K; Fuller, Carissa S; Cuchel, Marina; Rickels, Michael R.
+Institution
+ Gudipaty, Lalitha. Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
+ Rosenfeld, Nora K. Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
+ Fuller, Carissa S. Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
+ Cuchel, Marina. Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
+ Rickels, Michael R. Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
+MeSH Subject Headings
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Secretion
+ Insulin-Secreting Cells/me [Metabolism]
+ *Insulin-Secreting Cells/pa [Pathology]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Phenotype
+ Prognosis
+Keyword Heading
+ insulin secretion
+ insulin sensitivity
+ type 2 diabetes
+ beta-cell function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Type 2 diabetes (T2D) is characterized by impaired tissue sensitivity to insulin action (ie, insulin resistance) and impaired beta-cell insulin secretion. Because obesity contributes importantly to the development of insulin resistance, we sought to determine whether insulin secretory defects would predominate in non-obese compared to obese T2D.
+
+ METHODS: We measured beta-cell function and secretory capacity using the glucose-potentiated arginine test in T2D subjects early in the disease course classified as non-obese (BMI <30; n = 12) or obese (BMI >=30 kg/m2 ; n = 28) and additionally compared responses from non-obese T2D with a non-diabetic control group (n = 12).
+
+ RESULTS: The acute insulin response to glucose potentiation of arginine-induced insulin release was less in non-obese T2D than in controls and associated with impaired beta-cell sensitivity to glucose (PG50 ). Proinsulin secretory ratios were increased in non-obese T2D when compared to obese T2D. Obese T2D subjects had reduced insulin sensitivity (M/I) while non-obese T2D subjects had insulin sensitivity that was comparable to controls.
+
+ CONCLUSIONS: In non-obese T2D, insulin secretory defects predominate with impaired beta-cell sensitivity to glucose and proinsulin processing in the absence of insulin resistance. Future studies should consider whether different beta-cell secretory phenotypes and tissue sensitivity to insulin explain the varying responsiveness to T2D interventions. Copyright © 2020 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1002%2fdmrr.3295
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gudipaty&issn=1520-7552&title=Diabetes%2FMetabolism+Research+Reviews&atitle=Different+beta-cell+secretory+phenotype+in+non-obese+compared+to+obese+early+type+2+diabetes.&volume=36&issue=5&spage=e3295&epage=&date=2020&doi=10.1002%2Fdmrr.3295&pmid=32017362&sid=OVID:medline
+
+<1451>
+Unique Identifier
+ 32016415
+Title
+ Oxyntomodulin and Glicentin May Predict the Effect of Bariatric Surgery on Food Preferences and Weight Loss.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(4), 2020 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nielsen MS; Ritz C; Wewer Albrechtsen NJ; Holst JJ; le Roux CW; Sjodin A
+Authors Full Name
+ Nielsen, Mette S; Ritz, Christian; Wewer Albrechtsen, Nicolai J; Holst, Jens Juul; le Roux, Carel W; Sjodin, Anders.
+Institution
+ Nielsen, Mette S. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
+ Nielsen, Mette S. The Danish Diabetes Academy, Odense, Denmark.
+ Ritz, Christian. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
+ Wewer Albrechtsen, Nicolai J. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Wewer Albrechtsen, Nicolai J. Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
+ Holst, Jens Juul. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Holst, Jens Juul. NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ le Roux, Carel W. Investigative Science, Imperial College London, London, UK.
+ le Roux, Carel W. Diabetes Complications Research Centre, Conway Institute, University College Dublin, Dublin, Ireland.
+ Sjodin, Anders. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ *Bariatric Surgery/mt [Methods]
+ Biomarkers/an [Analysis]
+ Case-Control Studies
+ Energy Intake
+ Female
+ Follow-Up Studies
+ *Food Preferences
+ *Gastrectomy/mt [Methods]
+ *Gastric Bypass/mt [Methods]
+ *Glicentin/bl [Blood]
+ Humans
+ Male
+ Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ *Obesity/su [Surgery]
+ *Oxyntomodulin/bl [Blood]
+ Peptide YY/bl [Blood]
+ Prognosis
+ *Weight Loss
+Keyword Heading
+ bariatric surgery
+ gut hormones
+ predictors
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Alterations in several gastrointestinal hormones are implicated in the postoperative suppression of food intake leading to weight loss after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). The aim was to evaluate changes in responses of gastrointestinal hormones after RYGB and SG and the associations of these changes with weight loss, energy intake, and food preferences.
+
+ METHODS: Forty-two subjects with severe obesity were included (32 RYGB; 10 SG). Postprandial responses of glicentin, oxyntomodulin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and ghrelin were measured before and 6 months after surgery. Energy intake and energy density were assessed before and 6 months after surgery using a buffet meal test and weight loss was assessed 18 months after surgery.
+
+ RESULTS: Postprandial concentrations of glicentin, oxyntomodulin, GLP-1, and ghrelin differed between RYGB and SG (all P <= .02). Enhanced responses of glicentin and oxyntomodulin predicted a greater weight loss (both P < .01) and were associated with a larger decrease in energy density (P <= .04). No associations were found for GLP-1, PYY, and ghrelin, and changes were not associated with changes in energy intake. When combing all hormones, 60%, 19%, and 33% of the variations in weight loss, energy intake, and energy density, respectively, could be explained.
+
+ CONCLUSION: Postprandial responses of gastrointestinal hormones differed between RYGB and SG. Enhanced responses of glicentin and oxyntomodulin predicted a better weight loss and were associated with a decreased preference for energy-dense foods. Replication of these results could imply an opportunity to identify patients in need of additional support after surgical treatments of obesity. Copyright © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Oxyntomodulin). 106388-42-5 (Peptide YY). 71567-77-6 (Glicentin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1210%2fclinem%2fdgaa061
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nielsen&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Oxyntomodulin+and+Glicentin+May+Predict+the+Effect+of+Bariatric+Surgery+on+Food+Preferences+and+Weight+Loss.&volume=105&issue=4&spage=e1064&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgaa061&pmid=32016415&sid=OVID:medline
+
+<1452>
+Unique Identifier
+ 32016362
+Title
+ Mapping the Associations of the Plasma Lipidome With Insulin Resistance and Response to an Oral Glucose Tolerance Test.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(3), 2020 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Beyene HB; Hamley S; Giles C; Huynh K; Smith A; Cinel M; Mellet NA; Morales-Scholz MG; Kloosterman D; Howlett KF; Kowalski GM; Shaw CS; Magliano DJ; Bruce CR; Meikle PJ
+Authors Full Name
+ Beyene, Habtamu B; Hamley, Steven; Giles, Corey; Huynh, Kevin; Smith, Alexander; Cinel, Michelle; Mellet, Natalie A; Morales-Scholz, Maria G; Kloosterman, Danielle; Howlett, Kirsten F; Kowalski, Greg M; Shaw, Christopher S; Magliano, Dianna J; Bruce, Clinton R; Meikle, Peter J.
+Institution
+ Beyene, Habtamu B. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
+ Beyene, Habtamu B. Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
+ Hamley, Steven. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia.
+ Giles, Corey. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
+ Huynh, Kevin. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
+ Smith, Alexander. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
+ Cinel, Michelle. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
+ Mellet, Natalie A. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
+ Morales-Scholz, Maria G. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia.
+ Kloosterman, Danielle. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia.
+ Howlett, Kirsten F. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia.
+ Kowalski, Greg M. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia.
+ Shaw, Christopher S. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia.
+ Magliano, Dianna J. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
+ Magliano, Dianna J. Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
+ Bruce, Clinton R. Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
+ Meikle, Peter J. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
+ Meikle, Peter J. Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Australia/ep [Epidemiology]
+ *Biomarkers/bl [Blood]
+ Cohort Studies
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Glucose Intolerance/bl [Blood]
+ *Glucose Intolerance/ep [Epidemiology]
+ *Glucose Tolerance Test/mt [Methods]
+ Humans
+ *Insulin Resistance
+ *Lipidomics/mt [Methods]
+ *Lipids/bl [Blood]
+ Male
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Young Adult
+Keyword Heading
+ OGTT
+ high-throughput lipidomics
+ insulin resistance
+ lipid metabolism
+ young adults
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Insulin resistance (IR) remains a global health challenge. Lipidomics offers an opportunity to identify biomarkers and better understand mechanisms of IR associated with abnormal lipid metabolism.
+
+ OBJECTIVE: The objective of this article is to determine plasma lipid species associated with indices of IR and evaluate the lipidome response to an oral glucose tolerance test (OGTT).
+
+ DESIGN AND SETTING: This study was community based and cross-sectional.
+
+ PARTICIPANTS AND SAMPLE: Plasma samples (collected at 0 and 120 min during an OGTT) from nonobese, young adults age 18 to 34 years (n = 246) were analyzed using liquid chromatography-tandem mass spectrometry.
+
+ MAIN OUTCOME MEASURES: The associations between indices of IR and lipid classes and species (with a sex interaction term), or changes in lipid levels during an OGTT, were tested using linear models (adjusted for age, sex, body mass index, total cholesterol, high-density lipoprotein cholesterol, and triglycerides).
+
+ RESULTS: Some (213) and (199) lipid species were associated with the homeostatic model assessment of insulin resistance and insulin area under curve (AUC), respectively. Alkylphosphatidylcholine (10), alkenylphosphatidylcholine (23), and alkylphosphatidylethanolamine (6) species were associated with insulin AUC in men only. Species of phosphatidylcholine (7) and sphingomyelin (5) were associated in women only. In response to an OGTT, a perturbation in the plasma lipidome, particularly in acylcarnitine species, was observed; and the changes in many lipid species were associated with insulin AUC.
+
+ CONCLUSIONS: The plasma lipidome and changes in lipid levels during an OGTT were associated with indices of IR. These findings underlie the involvement of molecular lipid species in the pathogenesis of IR and possibly crosstalk between IR and sex-specific regulation of lipid metabolism. Copyright © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1210%2fclinem%2fdgaa054
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Beyene&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Mapping+the+Associations+of+the+Plasma+Lipidome+With+Insulin+Resistance+and+Response+to+an+Oral+Glucose+Tolerance+Test.&volume=105&issue=3&spage=e1041&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgaa054&pmid=32016362&sid=OVID:medline
+
+<1453>
+Unique Identifier
+ 32013008
+Title
+ Editorial of Special Issue "Adipokines 2.0".
+Source
+ International Journal of Molecular Sciences. 21(3), 2020 Jan 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Buechler C
+Author NameID
+ Buechler, Christa; ORCID: https://orcid.org/0000-0002-5635-3994
+Authors Full Name
+ Buechler, Christa.
+Institution
+ Buechler, Christa. Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ *Adipokines/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Healthy Lifestyle
+ Humans
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+Abstract
+ This editorial aims to summarize the 19 scientific papers that contributed to the Special Issue "Adipokines 2" [...].
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers).
+Publication Type
+ Editorial. Introductory Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijms21030849
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Buechler&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Editorial+of+Special+Issue+%22Adipokines+2.0%22.&volume=21&issue=3&spage=849&epage=&date=2020&doi=10.3390%2Fijms21030849&pmid=32013008&sid=OVID:medline
+
+<1454>
+Unique Identifier
+ 32001554
+Title
+ Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker.
+Source
+ Gut. 69(10):1855-1866, 2020 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baselli GA; Dongiovanni P; Rametta R; Meroni M; Pelusi S; Maggioni M; Badiali S; Pingitore P; Maurotti S; Montalcini T; Taliento AE; Prati D; Rossi G; Fracanzani AL; Mancina RM; Romeo S; Valenti L
+Author NameID
+ Dongiovanni, Paola; ORCID: https://orcid.org/0000-0003-4343-7213
+ Romeo, Stefano; ORCID: https://orcid.org/0000-0001-9168-4898
+ Valenti, Luca; ORCID: https://orcid.org/0000-0001-8909-0345
+Authors Full Name
+ Baselli, Guido Alessandro; Dongiovanni, Paola; Rametta, Raffaela; Meroni, Marica; Pelusi, Serena; Maggioni, Marco; Badiali, Sara; Pingitore, Piero; Maurotti, Samantha; Montalcini, Tiziana; Taliento, Alice Emma; Prati, Daniele; Rossi, Giorgio; Fracanzani, Anna Ludovica; Mancina, Rosellina Margherita; Romeo, Stefano; Valenti, Luca.
+Institution
+ Baselli, Guido Alessandro. Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milano, Lombardia, Italy.
+ Baselli, Guido Alessandro. Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Dongiovanni, Paola. General Medicine and Metabolic Diseases, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Rametta, Raffaela. General Medicine and Metabolic Diseases, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Meroni, Marica. General Medicine and Metabolic Diseases, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Pelusi, Serena. Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milano, Lombardia, Italy.
+ Pelusi, Serena. Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Maggioni, Marco. Pathology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Badiali, Sara. Surgery, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Pingitore, Piero. Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Calabria, Italy.
+ Maurotti, Samantha. Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Calabria, Italy.
+ Montalcini, Tiziana. Department of Clinical and Experimental Medicine, Nutrition Unit, Magna Graecia University of Catanzaro, Catanzaro, Calabria, Italy.
+ Taliento, Alice Emma. Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Prati, Daniele. Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Rossi, Giorgio. Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milano, Lombardia, Italy.
+ Rossi, Giorgio. Liver Transplantation Center, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy.
+ Fracanzani, Anna Ludovica. Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milano, Lombardia, Italy.
+ Fracanzani, Anna Ludovica. General Medicine and Metabolic Diseases, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+ Mancina, Rosellina Margherita. Department of Molecular and Clinical Medicine, Goteborgs Universitet, Goteborg, Sweden.
+ Romeo, Stefano. Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Calabria, Italy luca.valenti@unimi.it stefano.romeo@wlab.gu.se.
+ Romeo, Stefano. Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Cardiology Department, University of Gothenburg, Goteborg, Sweden.
+ Valenti, Luca. Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milano, Lombardia, Italy luca.valenti@unimi.it stefano.romeo@wlab.gu.se.
+ Valenti, Luca. Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Disease Progression
+ Drug Discovery
+ Female
+ *Gene Expression Profiling/mt [Methods]
+ Genetic Predisposition to Disease
+ Humans
+ *Interleukins/me [Metabolism]
+ *Lipase/ge [Genetics]
+ *Liver/me [Metabolism]
+ Male
+ *Membrane Proteins/ge [Genetics]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease
+ Obesity/me [Metabolism]
+ Polymorphism, Single Nucleotide
+ Severity of Illness Index
+ Up-Regulation
+Keyword Heading
+ cytokines
+ genetics
+ nonalcoholic steatohepatitis
+ rna expression
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Efforts to manage non-alcoholic fatty liver disease (NAFLD) are limited by the incomplete understanding of the pathogenic mechanisms and the absence of accurate non-invasive biomarkers. The aim of this study was to identify novel NAFLD therapeutic targets andbiomarkers by conducting liver transcriptomic analysis in patients stratified by the presence of the PNPLA3 I148M genetic risk variant.
+
+ DESIGN: We sequenced the hepatic transcriptome of 125 obese individuals. 'Severe NAFLD' was defined as the presence of steatohepatitis, NAFLD activity score >=4 or fibrosis stage >=2. The circulating levels of the most upregulated transcript, interleukin-32 (IL32), were measured by ELISA.
+
+ RESULTS: Carriage of the PNPLA3 I148M variant correlated with the two major components of hepatic transcriptome variability and broadly influenced gene expression. In patients with severe NAFLD, there was an upregulation of inflammatory and lipid metabolism pathways. IL32 was the most robustly upregulated gene in the severe NAFLD group (adjusted p=1x10-6), and its expression correlated with steatosis severity, both in I148M variant carriers and non-carriers. In 77 severely obese, and in a replication cohort of 160 individuals evaluated at the hepatology service, circulating IL32 levels were associated with both NAFLD and severe NAFLD independently of aminotransferases (p<0.01 for both). A linear combination of IL32-ALT-AST showed a better performance than ALT-AST alone in NAFLD diagnosis (area under the curve=0.92 vs 0.81, p=5x10-5).
+
+ CONCLUSION: Hepatic IL32 is overexpressed in NAFLD, correlates with hepatic fat and liver damage, and is detectable in the circulation, where it is independently associated with the presence and severity of NAFLD. Copyright © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IL32 protein, human). 0 (Interleukins). 0 (Membrane Proteins). EC 3-1-1-3 (Lipase). EC 3-1-1-3 (adiponutrin, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1136%2fgutjnl-2019-319226
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baselli&issn=0017-5749&title=Gut&atitle=Liver+transcriptomics+highlights+interleukin-32+as+novel+NAFLD-related+cytokine+and+candidate+biomarker.&volume=69&issue=10&spage=1855&epage=1866&date=2020&doi=10.1136%2Fgutjnl-2019-319226&pmid=32001554&sid=OVID:medline
+
+<1455>
+Unique Identifier
+ 31997284
+Title
+ Physiological Significance of Discrimination on Stress Markers, Obesity, and LDL Oxidation among a European American and African American Cohort of Females.
+Source
+ International Journal of Behavioral Medicine. 27(2):213-224, 2020 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cedillo YE; Lomax RO; Fernandez JR; Moellering DR
+Author NameID
+ Cedillo, Yenni E; ORCID: http://orcid.org/0000-0001-6177-1077
+Authors Full Name
+ Cedillo, Yenni E; Lomax, Rachel O; Fernandez, Jose R; Moellering, Douglas R.
+Institution
+ Cedillo, Yenni E. Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Webb Building 552, 1675 University Blvd, Birmingham, AL, 35294-3360, USA. yennicj@uab.edu.
+ Lomax, Rachel O. Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Webb Building 552, 1675 University Blvd, Birmingham, AL, 35294-3360, USA.
+ Fernandez, Jose R. Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Webb Building 552, 1675 University Blvd, Birmingham, AL, 35294-3360, USA.
+ Moellering, Douglas R. Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Webb Building 552, 1675 University Blvd, Birmingham, AL, 35294-3360, USA.
+ Moellering, Douglas R. UAB Bioanalytical Redox Biology Core, Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Webb Building 552, 1675 University Blvd, Birmingham, AL, USA.
+MeSH Subject Headings
+ Adult
+ *Black or African American/sn [Statistics & Numerical Data]
+ Biomarkers/me [Metabolism]
+ Blood Pressure
+ Body Mass Index
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cholesterol, LDL/bl [Blood]
+ Cohort Studies
+ Cross-Sectional Studies
+ Female
+ Humans
+ Hydrocortisone/an [Analysis]
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ United States
+ Waist Circumference
+ *White People/sn [Statistics & Numerical Data]
+ Young Adult
+Keyword Heading
+ Cortisol
+ Discrimination
+ Health disparities
+ Inflammation
+ Oxidative stress
+ Stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Factors underlying physiological reactions from perceived discrimination and its relation to adverse health outcomes are not completely understood. The main purpose of this study was to test the hypothesis that experiences of discrimination (recent and lifetime) correlate with biomarkers of stress, oxidative stress, and obesity among adult females.
+
+ METHOD: Data on 62 females who self-identify as African American (AA; n = 31) or European American (EA; n = 31) aged 21-45 years were included. Discrimination experiences (recent and lifetime) were evaluated based on a validated instrument. Stress was assessed based on hair cortisol (HC) and salivary cortisol (SC), hsC-reactive protein (hsCRP), cardiovascular markers, and LDL-cholesterol oxidation. Obesity was measured based on BMI, waist circumference, and body fat percent. Multiple linear regression analyses were performed to evaluate the influence of experiences of discrimination.
+
+ RESULTS: Significant differences in experiences of discrimination were observed by race (p < 0.05) and were higher in AA females. Results for the multiple regression models assessing the contribution of discrimination indicate that hsCRP and pulse were significantly associated with recent experiences of discrimination, and SC, HC, hsCRP, diastolic blood pressure (DBP), and pulse were significantly associated with lifetime experiences of discrimination when adjusted for BMI and race (p < 0.05). Finally, oxidation of LDL-cholesterol was significantly associated with salivary cortisol (p = 0.0420) when adjusted by lifetime experiences of discrimination (p = 0.0366) but not for BMI (p = 0.6252).
+
+ CONCLUSION: In this cross-sectional study, AA females experienced more discrimination compared to EA females. Levels of recent and lifetime experiences of discrimination were associated with some stress biomarkers. Salivary cortisol was associated with oxidation of LDL-cholesterol with shorter lag times and increased risk for cardiovascular disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs12529-020-09850-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cedillo&issn=1070-5503&title=International+Journal+of+Behavioral+Medicine&atitle=Physiological+Significance+of+Discrimination+on+Stress+Markers%2C+Obesity%2C+and+LDL+Oxidation+among+a+European+American+and+African+American+Cohort+of+Females.&volume=27&issue=2&spage=213&epage=224&date=2020&doi=10.1007%2Fs12529-020-09850-3&pmid=31997284&sid=OVID:medline
+
+<1456>
+Unique Identifier
+ 31996062
+Title
+ A novel biochemical marker -OKL38- with its apoptotic and antioxidant properties for the development of PCOS and its related clinical implications.
+Source
+ Gynecological Endocrinology. 36(8):673-677, 2020 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yetkin Yildirim G; Tola EN; Dag I
+Authors Full Name
+ Yetkin Yildirim, Gonca; Tola, Esra Nur; Dag, Ismail.
+Institution
+ Yetkin Yildirim, Gonca. Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
+ Tola, Esra Nur. Department of Obstetrics and Gynecology, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.
+ Dag, Ismail. Department of Biochemistry, Eyup State Hospital, Istanbul, Turkey.
+MeSH Subject Headings
+ Adult
+ Antioxidants/me [Metabolism]
+ Antioxidants/ph [Physiology]
+ Apoptosis Regulatory Proteins/bl [Blood]
+ *Apoptosis Regulatory Proteins/ph [Physiology]
+ *Biomarkers/bl [Blood]
+ Cardiometabolic Risk Factors
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ Case-Control Studies
+ Female
+ Hirsutism/bl [Blood]
+ Hirsutism/di [Diagnosis]
+ Hirsutism/et [Etiology]
+ Humans
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/et [Etiology]
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ *Polycystic Ovary Syndrome/et [Etiology]
+ Prognosis
+ Risk Factors
+ Young Adult
+Keyword Heading
+ OKL38
+ PCOS
+ cardiovascular disease risk
+ metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aim: To investigate the role of serum OKL38 levels in the development of polycystic ovary syndrome (PCOS) and clinical implications related to PCOS. Method: PCOS (n = 33) and ovulatory controls (n = 48) were recruited for the study. Anthropometric measurements were recorded, and blood samples for hormonal and biochemical parameters including serum OKL38 levels were obtained. The potential role of OKL38 on the development of PCOS, metabolic syndrome and cardiovascular disease (CVD) were investigated. Framingham risk score (FRS) was used for the determination of CVD risk. Results: Mean Ferriman-Gallway (FG) score, insulin, low-density lipoprotein (LDL), total cholesterol (TC) levels, and the homeostasis model assessment of insulin resistance index (HOMA-IR) were significantly increased (p < .05) in women with PCOS compared to controls. PCOS group had lower mean OKL38 level compared to controls (p < .0001) and OKL38 was negatively predictive for the diagnosis of PCOS after adjustment of variables that were significantly different between two groups. A negative association between OKL38 and metabolic syndrome in PCOS women was evident after adjustment for age, obesity, and abdominal obesity. OKL38 level was also negatively correlated with body mass index, waist-to-hip-ratio, fat composition, serum TC, LDL, free testosterone levels, FRS, and FG scores. Conclusion: OKL38 may have a partial role in the etiopathogenesis of PCOS and may protect development of metabolic syndrome and CVD in women with PCOS.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Apoptosis Regulatory Proteins). 0 (Biomarkers). 0 (OSGIN1 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1080%2f09513590.2020.1718641
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yetkin+Yildirim&issn=0951-3590&title=Gynecological+Endocrinology&atitle=A+novel+biochemical+marker+-OKL38-+with+its+apoptotic+and+antioxidant+properties+for+the+development+of+PCOS+and+its+related+clinical+implications.&volume=36&issue=8&spage=673&epage=677&date=2020&doi=10.1080%2F09513590.2020.1718641&pmid=31996062&sid=OVID:medline
+
+<1457>
+Unique Identifier
+ 31991894
+Title
+ Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice.
+Source
+ Nutrients. 12(2), 2020 Jan 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Claro-Cala CM; Quintela JC; Perez-Montero M; Minano J; de Sotomayor MA; Herrera MD; Rodriguez-Rodriguez AR
+Author NameID
+ Perez-Montero, Marta; ORCID: https://orcid.org/0000-0001-9573-5330
+ de Sotomayor, Maria Alvarez; ORCID: https://orcid.org/0000-0001-8466-1698
+Authors Full Name
+ Claro-Cala, Carmen Maria; Quintela, Jose Carlos; Perez-Montero, Marta; Minano, Javier; de Sotomayor, Maria Alvarez; Herrera, Maria Dolores; Rodriguez-Rodriguez, And Rosalia.
+Institution
+ Claro-Cala, Carmen Maria. Department of Pharmacology, Pediatric and Radiology, Faculty of Medicine, University of Sevilla, E-41009 Sevilla, Spain.
+ Quintela, Jose Carlos. Natac Biotech S.L., Electronica 7, 28923 Alcorcon, Madrid, Spain.
+ Perez-Montero, Marta. Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Valles, Spain.
+ Minano, Javier. Department of Pharmacology, Pediatric and Radiology, Faculty of Medicine, University of Sevilla, E-41009 Sevilla, Spain.
+ de Sotomayor, Maria Alvarez. Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla, Spain.
+ Herrera, Maria Dolores. Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla, Spain.
+ Rodriguez-Rodriguez, And Rosalia. Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Valles, Spain.
+MeSH Subject Headings
+ Adiposity
+ Animals
+ *Aorta, Thoracic/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Diet, High-Fat
+ *Diet, Mediterranean
+ Disease Models, Animal
+ Disease Progression
+ Insulin Resistance
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ *Obesity/pc [Prevention & Control]
+ *Oleanolic Acid/ad [Administration & Dosage]
+ Oleanolic Acid/an [Analysis]
+ *Olive Oil/ad [Administration & Dosage]
+ Olive Oil/ch [Chemistry]
+ *Triterpenes/ad [Administration & Dosage]
+ Triterpenes/an [Analysis]
+ *Vasoconstriction
+ *Vasodilation
+ Weight Gain
+Keyword Heading
+ Mediterranean diet
+ maslinic acid
+ obesity
+ oleanolic acid
+ pomace olive oil
+ vascular function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Olive Oil). 0 (Triterpenes). 6SMK8R7TGJ (Oleanolic Acid). E233J88OHQ (maslinic acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12020323
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Claro-Cala&issn=2072-6643&title=Nutrients&atitle=Pomace+Olive+Oil+Concentrated+in+Triterpenic+Acids+Restores+Vascular+Function%2C+Glucose+Tolerance+and+Obesity+Progression+in+Mice.&volume=12&issue=2&spage=&epage=&date=2020&doi=10.3390%2Fnu12020323&pmid=31991894&sid=OVID:medline
+
+<1458>
+Unique Identifier
+ 31987123
+Title
+ The association between metabolic syndrome components, low-grade systemic inflammation and insulin resistance in non-diabetic Indonesian adolescent male.
+Source
+ Clinical Nutrition ESPEN. 35:69-74, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mansyur MA; Bakri S; Patellongi IJ; Rahman IA
+Authors Full Name
+ Mansyur, Makbul Aman; Bakri, Syakib; Patellongi, Ilham Jaya; Rahman, Ilham Akbar.
+Institution
+ Mansyur, Makbul Aman. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Faculty of Medicine of Hasanuddin University, Makassar, Indonesia. Electronic address: makbul_aman@yahoo.com.
+ Bakri, Syakib. Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine of Hasanuddin University, Makassar, Indonesia.
+ Patellongi, Ilham Jaya. Department of Physiology, Faculty of Medicine of Hasanuddin University, Makassar, Indonesia.
+ Rahman, Ilham Akbar. Faculty of Medicine of Hasanuddin University, Makassar, Indonesia.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Cholesterol, HDL/bl [Blood]
+ Cholesterol, LDL/bl [Blood]
+ Cross-Sectional Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Fasting
+ Humans
+ Indonesia/ep [Epidemiology]
+ *Inflammation/bl [Blood]
+ *Inflammation/ep [Epidemiology]
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Obesity/bl [Blood]
+ Risk Factors
+ Triglycerides/bl [Blood]
+ Young Adult
+Keyword Heading
+ Adolescence
+ C-reactive protein
+ Childhood
+ Indonesia
+ Insulin resistance
+ Obesity
+ Risk factors
+ Triacylglycerol
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Millions of people in Indonesia have diabetes. The cluster of metabolic abnormalities has long been identified as the risk factors for type 2 diabetes and is now commonly described as metabolic syndrome/MetS. Insulin resistance takes a key role in the process of the MetS and has even been hypothesized as its underlying cause. Clinical and epidemiologic studies also indicate that inflammatory factors might be correlated with IR. Prospective studies have proved that metabolic syndrome grows during childhood/adolescence and progresses to adulthood T2DM. The purpose of this study was to investigate relationships between metabolic syndrome components and low-grade systemic inflammation with insulin resistance in non-diabetic Indonesian adolescent male.
+
+ METHODS: This was a cross-sectional analysis of non-diabetic adolescent male in Indonesian population (n = 128) aged between 18 and 22 years old. MetS components are based on NCEP ATP III (2004) modification for Asia Pacific population. Marker for low-grade systemic inflammation is hsCRP and insulin resistance was determined by HOMA-IR formula. Relevant measures were anthropometry, blood pressure, fasting insulin, serum glucose, lipid profiles and hsCRP.
+
+ RESULTS: Of the 128 adolescent male, we found that 16 subjects (12.5%) have central obesity; 3 subjects (2.3%) have hyperglycemia; 26 subjects (20.3%) have low HDL-c; 19 subjects (14.8%) have high triacylglycerol; 45 subjects (35.2%) have hsCRP >=1.0 mg/dL; 4 subjects (3.1%) have high blood pressure and 39 subjects (30.5%) have insulin resistance. The association of MetS components with the risk of insulin resistance is central obesity and high triacylglycerol with OR of 24.4 (95%CI: 5.19-114.42) and 9.4 (95%CI: 3.09-28.68) consecutively. We also found that low-grade systemic inflammation (hsCRP >=1.0 mg/dL) was strongly associated with incident of insulin resistance with OR 5.2 (95%CI: 2.31-11.64). Meanwhile, we found that high triacylglycerol level is the solely one of five MetS components which has contribution to the incident of systemic low-grade inflammation with OR 3.9 (95%CI: 1.43-10.92).
+
+ CONCLUSION: Central obesity and high triacylglycerol level are the important MetS components associated with IR. Systemic low-grade inflammation has been associated with insulin resistance. Identification of obesity, high triacylglycerol and high hsCRP should be focused for prevention of type 2 diabetes in non-diabetic Indonesian adolescent male. Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Insulin). 0 (Triglycerides). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.clnesp.2019.12.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mansyur&issn=2405-4577&title=Clinical+Nutrition+ESPEN&atitle=The+association+between+metabolic+syndrome+components%2C+low-grade+systemic+inflammation+and+insulin+resistance+in+non-diabetic+Indonesian+adolescent+male.&volume=35&issue=&spage=69&epage=74&date=2020&doi=10.1016%2Fj.clnesp.2019.12.001&pmid=31987123&sid=OVID:medline
+
+<1459>
+Unique Identifier
+ 31986486
+Title
+ Late-life obesity is a protective factor for prodromal Alzheimer's disease: a longitudinal study.
+Source
+ Aging. 12(2):2005-2017, 2020 01 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sun Z; Wang ZT; Sun FR; Shen XN; Xu W; Ma YH; Dong Q; Tan L; Yu JT
+Corporate Author
+ Alzheimer's Disease Neuroimaging Initiative
+Authors Full Name
+ Sun, Zhen; Wang, Zuo-Teng; Sun, Fu-Rong; Shen, Xue-Ning; Xu, Wei; Ma, Ya-Hui; Dong, Qiang; Tan, Lan; Yu, Jin-Tai.
+Institution
+ Sun, Zhen. Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China.
+ Wang, Zuo-Teng. College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China.
+ Sun, Fu-Rong. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Shen, Xue-Ning. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
+ Xu, Wei. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Ma, Ya-Hui. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Dong, Qiang. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
+ Tan, Lan. Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China.
+ Tan, Lan. College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China.
+ Tan, Lan. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
+ Yu, Jin-Tai. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
+ Alzheimer's Disease Neuroimaging Initiative. Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.
+MeSH Subject Headings
+ Age of Onset
+ Aged
+ Aged, 80 and over
+ *Alzheimer Disease/co [Complications]
+ Alzheimer Disease/di [Diagnosis]
+ *Alzheimer Disease/ep [Epidemiology]
+ Amyloid beta-Peptides/me [Metabolism]
+ Biomarkers
+ Body Mass Index
+ Comorbidity
+ Disease Susceptibility
+ Female
+ Humans
+ Kaplan-Meier Estimate
+ Longitudinal Studies
+ Magnetic Resonance Imaging
+ Male
+ Neuroimaging
+ Neuropsychological Tests
+ *Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ Public Health Surveillance
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ Alzheimer's disease
+ biomarker
+ body mass index
+ brain volume
+ cognition
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Higher body mass index (BMI) in late-life has recently been considered as a possible protective factor for Alzheimer's disease (AD), which yet remains conflicting. To test this hypothesis, we have evaluated the cross-sectional and longitudinal associations of BMI categories with CSF biomarkers, brain beta-amyloid (Abeta) load, brain structure, and cognition and have assessed the effect of late-life BMI on AD risk in a large sample (n = 1,212) of non-demented elderly from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. At baseline, higher late-life BMI categories were associated with higher levels of CSF Abeta42 (p=0.037), lower levels of CSF total-tau (t-tau, p=0.026) and CSF t-tau/Abeta42 (p=0.008), lower load of Abeta in the right hippocampus (p=0.030), as well as larger volumes of hippocampus (p<0.0001), entorhinal cortex (p=0.009) and middle temporal lobe (p=0.040). But no association was found with CSF phosphorylated-tau (p-tau) or CSF p-tau/Abeta42. Longitudinal studies showed that higher BMI individuals experienced a slower decline in cognitive function. In addition, Kaplan-Meier survival analysis revealed that higher late-life BMI had a reduced risk of progression to AD over time (p = 0.009). Higher BMI in late-life decreased the risk of AD, and this process may be driven by AD-related biomarkers.
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Peptides). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.18632%2faging.102738
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sun&issn=1945-4589&title=Aging&atitle=Late-life+obesity+is+a+protective+factor+for+prodromal+Alzheimer%27s+disease%3A+a+longitudinal+study.&volume=12&issue=2&spage=2005&epage=2017&date=2020&doi=10.18632%2Faging.102738&pmid=31986486&sid=OVID:medline
+
+<1460>
+Unique Identifier
+ 31983693
+Title
+ Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity.
+Source
+ Aging. 12(2):1725-1746, 2020 01 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Varghese M; Griffin C; McKernan K; Eter L; Abrishami S; Singer K
+Authors Full Name
+ Varghese, Mita; Griffin, Cameron; McKernan, Kaitlin; Eter, Leila; Abrishami, Simin; Singer, Kanakadurga.
+Institution
+ Varghese, Mita. Department of Pediatrics, Division of Endocrinology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
+ Griffin, Cameron. Department of Pediatrics, Division of Endocrinology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
+ McKernan, Kaitlin. Department of Pediatrics, Division of Endocrinology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
+ Eter, Leila. Department of Pediatrics, Division of Endocrinology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
+ Abrishami, Simin. Department of Pediatrics, Division of Endocrinology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
+ Singer, Kanakadurga. Department of Pediatrics, Division of Endocrinology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
+MeSH Subject Headings
+ *Adaptation, Physiological
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Adiposity
+ Age Factors
+ *Aging/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Cellular Senescence
+ Diet, High-Fat
+ *Energy Metabolism
+ Extracellular Matrix/me [Metabolism]
+ Female
+ Fibrosis
+ Immunohistochemistry
+ Intra-Abdominal Fat/me [Metabolism]
+ Lipid Metabolism
+ Lipolysis
+ Liver/im [Immunology]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Macrophages/im [Immunology]
+ Macrophages/me [Metabolism]
+ Male
+ Mice
+ *Obesity/me [Metabolism]
+ Sex Factors
+Keyword Heading
+ adipose tissue macrophages
+ aging
+ extracellular matrix remodeling
+ senescence
+ sex differences
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aging, like obesity, is associated with metabolic and inflammatory alterations within adipose tissue in older individuals. Younger females are protected from adipose inflammation, but older post-menopausal females exhibit exaggerated visceral adiposity correlated with increased disease risk. Obesity accelerates the onset and progression of age-associated diseases, but it is unclear if aging and obesity drive adipose tissue dysfunction in a sexually dimorphic fashion. We investigated adipose tissue metabolism and inflammation in a diet-induced obesity model in young and old mice. We identified age related sex differences in adipose tissue macrophages (ATMs), fibrosis and lipid metabolism in male and female visceral fat depot (GWAT). Although aging normalized body weights between the sexes, females remained protected from proinflammatory ATMs and stimulated lipolysis failed to adversely affect the inflammatory state even with obesity. Older obese males had augmented CD11c+ ATMs and higher insulin levels, while females showed increased visceral adiposity and exaggerated Ppargamma, and Pgc1alpha expression. Obesity in aging demonstrated similar expression of GWAT p53, p16, p21, Timp1 and Tgfbeta1 in both sexes. Our studies suggest that even with aging, female GWAT shows an attenuated inflammatory response compared to males due to an efficient oxidative metabolism combined with an active tissue remodeling state.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.18632%2faging.102709
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Varghese&issn=1945-4589&title=Aging&atitle=Female+adipose+tissue+has+improved+adaptability+and+metabolic+health+compared+to+males+in+aged+obesity.&volume=12&issue=2&spage=1725&epage=1746&date=2020&doi=10.18632%2Faging.102709&pmid=31983693&sid=OVID:medline
+
+<1461>
+Unique Identifier
+ 31981682
+Title
+ The effect of age and obesity on platelet amyloid precursor protein processing and plasma markers of oxidative stress and inflammation.
+Source
+ Experimental Gerontology. 132:110838, 2020 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elsworthy RJ; Aldred S
+Authors Full Name
+ Elsworthy, Richard J; Aldred, Sarah.
+Institution
+ Elsworthy, Richard J. School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, UK.
+ Aldred, Sarah. School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, UK. Electronic address: s.aldred.1@bham.ac.uk.
+MeSH Subject Headings
+ ADAM10 Protein/me [Metabolism]
+ Adult
+ Aged
+ Aging
+ Alzheimer Disease/me [Metabolism]
+ Amyloid Precursor Protein Secretases/me [Metabolism]
+ *Amyloid beta-Protein Precursor/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ *Blood Platelets/me [Metabolism]
+ Body Mass Index
+ Dinoprost/aa [Analogs & Derivatives]
+ Female
+ Humans
+ *Inflammation/me [Metabolism]
+ Male
+ *Obesity/me [Metabolism]
+ Oxidative Stress
+ *Plasma/me [Metabolism]
+ Young Adult
+Keyword Heading
+ ADAM10
+ Ageing
+ Amyloid precursor protein
+ Inflammation
+ Obesity
+ Oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Advancing age is a major risk factor for a range of diseases such as, cardiovascular disease, diabetes, cancer and neurodegenerative diseases. In addition, over a third of the population are overweight and obesity is becoming more prevalent in younger people. Ageing and obesity are both linked to a chronic proinflammatory state and elevated oxidative stress, which have both been implicated in cardiovascular and neurodegenerative diseases. Platelets contain all the necessary machinery to process the Amyloid precursor protein AbetaPP, a pathway thought to be perturbed in Alzheimer's Disease (AD). The ratio of AbetaPP isoforms present in platelets, and the amount of alpha secretase ADAM10, that works to process AbetaPP, appear to be associated with cognitive decline and a diagnosis of Alzheimer's disease. The aim of this study was to assess changes in AbetaPP ratio, ADAM10 and markers of inflammation and oxidative stress with ageing and obesity.
+
+ MATERIALS AND METHODS: Ninety participants were recruited to this study to provide one blood sample. Platelet-rich plasma and platelet lysates were collected and the expression of AbetaPPr, proADAM10 and mADAM10 was assessed by Western blotting. In addition, markers of inflammation (IL-6) and oxidative stress (8-Isoprostane) were assessed in plasma.
+
+ RESULTS: Participants were placed into one of four groups based on their age and body mass index (Young/Lean, Young/obese, Old/Lean and Old/Obese). IL-6 was able to significantly distinguish obese from lean participants (AUC of 0.80, SE = 0.05, P < 0.001). Plasma isoprostanes were able to distinguish between both young/old (AUC of 0.73, SE = 0.05, P < 0.01), and obese/non-obese participants (AUC of 0.66, SE = 0.01, P < 0.01). Plasma protein carbonyls could distinguish young and old participants (AUC of 0.69, SE = 0.07 P < 0.02). Old Lean participants had significantly lower mADAM10 expression than both Young Lean and Young Obese participants (p < 0.05). Old obese participants had significantly lower proADAM10 expression compared to both Young Lean and Young Obese (p < 0.05). Both mADAM10 and proADAM10 were significantly decreased with advancing age (p < 0.05).
+
+ CONCLUSIONS: The findings presented in this study provide evidence that blood-based biomarkers related to the pathology of AD are altered with age and obesity in otherwise healthy adults. Ageing was more strongly associated with elevated markers of oxidative stress whereas obesity was associated with elevated inflammatory IL-6. Copyright © 2020 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Amyloid beta-Protein Precursor). 0 (Biomarkers). 27415-26-5 (8-epi-prostaglandin F2alpha). B7IN85G1HY (Dinoprost). EC 3-4 (Amyloid Precursor Protein Secretases). EC 3-4-24-81 (ADAM10 Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.exger.2020.110838
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elsworthy&issn=0531-5565&title=Experimental+Gerontology&atitle=The+effect+of+age+and+obesity+on+platelet+amyloid+precursor+protein+processing+and+plasma+markers+of+oxidative+stress+and+inflammation.&volume=132&issue=&spage=110838&epage=&date=2020&doi=10.1016%2Fj.exger.2020.110838&pmid=31981682&sid=OVID:medline
+
+<1462>
+Unique Identifier
+ 31971865
+Title
+ Weight Loss and Diabetes Control Following Laparoscopic Sleeve Gastrectomy.
+Source
+ Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. 30(4):383-388, 2020 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abdelbaki TN; El-Sayes I; Talha A; Sharaan MA
+Authors Full Name
+ Abdelbaki, Tamer N; El-Sayes, Islam; Talha, Ahmed; Sharaan, Mohamed Abdallah.
+Institution
+ Abdelbaki, Tamer N. General Surgery Department, Alexandria University Faculty of Medicine, Alexandria, Egypt.
+ El-Sayes, Islam. General Surgery Department, Alexandria University Faculty of Medicine, Alexandria, Egypt.
+ Talha, Ahmed. General Surgery Department, Medical Research Institute, Alexandria, Egypt.
+ Sharaan, Mohamed Abdallah. General Surgery Department, Alexandria University Faculty of Medicine, Alexandria, Egypt.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ Databases, Factual
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/su [Surgery]
+ Female
+ Follow-Up Studies
+ *Gastrectomy/mt [Methods]
+ Humans
+ *Laparoscopy
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/su [Surgery]
+ Postoperative Period
+ Remission Induction
+ Treatment Outcome
+ *Weight Loss
+Keyword Heading
+ bariatric surgery
+ diabetes
+ laparoscopic sleeve gastrectomy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Data following laparoscopic sleeve gastrectomy (LSG) for type 2 diabetes mellitus obese patients are extremely variable and we herein present our results. Methods: The data of 320 (90 diabetic) obese patients who had LSG were retrieved from prospectively collected database. Postoperative weight loss and glycemic control were evaluated during 24 months follow-up. Results: Diabetic patients had a significantly higher percentage excess weight loss (%EWL) (60.21 +/- 11 and 72.9 +/- 13) than nondiabetics (53.4 +/- 12 and 62.5 +/- 29) at 12 and 24 months post LSG, respectively. Diabetic patients with body mass index (BMI) >40 kg/m2 had significantly higher %EWL (64.17 +/- 13 and 75.2 +/- 16) than patients with BMI <=40 at 12 and 24 months, respectively. The mean glycated hemoglobin and fasting blood glucose were 6.6% +/- 1.4%, 6.1% +/- 1.1%, 5.9% +/- 1.2%, 5.8% +/- 0.5%, and 110 +/- 1.6 mg/dL, 106.7 +/- 1.8 mg/dL, 99.2 +/- 1.9 mg/dL, and 98.1 +/- 1.2 mg/dL at 1, 6, 12, and 24 months, respectively. All patients had complete diabetes remission at 12 months, and this was maintained at 24 months. Conclusion: Diabetic obese patients with BMI >40 kg/m2, had a better %EWL compared with nondiabetics and to diabetics with lower BMI. Diabetes remission started early at 1 month. At 12 months, all diabetics had complete diabetes remission and this was maintained at 24 months. Our results need to be validated in a larger study, which evaluates impact of gastrointestinal motility on diabetes control.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1089%2flap.2019.0680
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abdelbaki&issn=1092-6429&title=Journal+of+Laparoendoscopic+%26+Advanced+Surgical+Techniques.+Part+A&atitle=Weight+Loss+and+Diabetes+Control+Following+Laparoscopic+Sleeve+Gastrectomy.&volume=30&issue=4&spage=383&epage=388&date=2020&doi=10.1089%2Flap.2019.0680&pmid=31971865&sid=OVID:medline
+
+<1463>
+Unique Identifier
+ 31968607
+Title
+ Seabuckthorn (Hippophae rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice.
+Source
+ Nutrients. 12(1), 2020 Jan 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Guo C; Han L; Li M; Yu L
+Author NameID
+ Guo, Caixia; ORCID: https://orcid.org/0000-0002-9951-7661
+Authors Full Name
+ Guo, Caixia; Han, Li; Li, Meiping; Yu, Ligang.
+Institution
+ Guo, Caixia. School of Life Science, Shanxi University, Taiyuan 030006, China.
+ Han, Li. School of Life Science, Shanxi University, Taiyuan 030006, China.
+ Li, Meiping. School of Life Science, Shanxi University, Taiyuan 030006, China.
+ Yu, Ligang. School of Life Science, Shanxi University, Taiyuan 030006, China.
+MeSH Subject Headings
+ Adiposity/de [Drug Effects]
+ Animals
+ Anti-Obesity Agents/ip [Isolation & Purification]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Disease Models, Animal
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/ge [Genetics]
+ Dyslipidemias/mi [Microbiology]
+ *Dyslipidemias/pc [Prevention & Control]
+ Freeze Drying
+ *Gastrointestinal Microbiome/de [Drug Effects]
+ Gene Expression Regulation
+ Hippophae/ch [Chemistry]
+ *Hippophae
+ Hypolipidemic Agents/ip [Isolation & Purification]
+ *Hypolipidemic Agents/pd [Pharmacology]
+ *Lipids/bl [Blood]
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Obesity/mi [Microbiology]
+ *Obesity/pc [Prevention & Control]
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ Powders
+ *Weight Gain/de [Drug Effects]
+Keyword Heading
+ gut microbiota
+ lipid metabolism disorders
+ obesity
+ seabuckthorn freeze-dried powder
+ short-chain fatty acids (SCFAs)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study aimed to investigate the beneficial effects of seabuckthorn freeze-dried powder on high-fat diet-induced obesity and related lipid metabolism disorders, and further explored if this improvement is associated with gut microbiota. Results showed that seabuckthorn freeze-dried powder administration decreased body weight, Lee's index, adipose tissue weight, liver weight, and serum lipid levels. Moreover, treatment with seabuckthorn freeze-dried powder effectively reduced fat accumulation by modulating the relative expression of genes involved in lipid metabolism through down-regulation of encoding lipogenic and store genes, including SREBP-1c, PPAR-gamma, ACC, and SCD1, and up-regulation of regulating genes of fatty acid oxidation, including HSL, CPT-1, and ACOX. Especially, seabuckthorn freeze-dried powder regulated the composition of gut microbiota, such as increasing the ratio of Firmicutes/Bacteroidetes, decreasing relative abundance of harmful bacteria (Desulfovibrio), and increasing relative abundance of beneficial bacteria (Akkermansia and Bacteroides). The changes of beneficial bacteria had a positive correlation with genes encoding lipolysis and a negative correlation with genes encoding lipid lipogenesis and store. The harmful bacteria were just the opposite. Besides, changes in gut microbiota had an obvious effect in the secretion of main metabolites-short-chain fatty acids (SCFAs), especially propionic acid. Thus, our results indicated that the seabuckthorn freeze-dried powder could ameliorate high-fat diet-induced obesity and obesity-associated lipid metabolism disorders by changing the composition and structure of gut microbiota.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Hypolipidemic Agents). 0 (Lipids). 0 (Plant Extracts). 0 (Powders).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12010265
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Guo&issn=2072-6643&title=Nutrients&atitle=Seabuckthorn+%28Hippophae+rhamnoides%29+Freeze-Dried+Powder+Protects+against+High-Fat+Diet-Induced+Obesity%2C+Lipid+Metabolism+Disorders+by+Modulating+the+Gut+Microbiota+of+Mice.&volume=12&issue=1&spage=&epage=&date=2020&doi=10.3390%2Fnu12010265&pmid=31968607&sid=OVID:medline
+
+<1464>
+Unique Identifier
+ 31965068
+Title
+ Depot-specific UCP1 expression in human white adipose tissue and its association with obesity-related markers.
+Source
+ International Journal of Obesity. 44(3):697-706, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lim J; Park HS; Kim J; Jang YJ; Kim JH; Lee Y; Heo Y
+Authors Full Name
+ Lim, Jisun; Park, Hye Soon; Kim, Jimin; Jang, Yeon Jin; Kim, Jong-Hyeok; Lee, YeonJi; Heo, Yoonseok.
+Institution
+ Lim, Jisun. Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
+ Park, Hye Soon. Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. hyesoon@amc.seoul.kr.
+ Kim, Jimin. Department of Physiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
+ Jang, Yeon Jin. Department of Physiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. yjjang@amc.seoul.kr.
+ Kim, Jong-Hyeok. Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
+ Lee, YeonJi. Department of Family Medicine, College of Medicine, Inha University, Incheon, Republic of Korea.
+ Heo, Yoonseok. Department of General Surgery, College of Medicine, Inha University, Incheon, Republic of Korea.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ *Adipose Tissue, White/me [Metabolism]
+ Adult
+ Biomarkers/me [Metabolism]
+ Cells, Cultured
+ Endoplasmic Reticulum Stress/ph [Physiology]
+ Female
+ Humans
+ Inflammation/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ Middle Aged
+ *Obesity/me [Metabolism]
+ RNA, Messenger/me [Metabolism]
+ Uncoupling Protein 1/an [Analysis]
+ Uncoupling Protein 1/ge [Genetics]
+ Uncoupling Protein 1/me [Metabolism]
+ *Uncoupling Protein 1
+Abstract
+ BACKGROUND: This study investigated depot-specific mRNA expression of uncoupling protein 1 (UCP1) in human white adipose tissue (WAT) and its association with obesity-related markers.
+
+ METHODS: We recruited 39 normal-weight, 41 nondiabetic obese, and 22 diabetic obese women. We measured UCP1 mRNA expression in abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and investigated the associations between UCP1 mRNA expression in VAT and SAT, and obesity-related markers including mRNA expression of leptin, adiponectin, CCAAT-enhancer-binding protein homologous protein (CHOP), and positive regulatory domain-containing protein 16 (PRDM16). We also evaluated UCP1 mRNA expression in differentiated human white adipocytes after treatment with various stressors and metabolic improvement agents in vitro.
+
+ RESULTS: UCP1 mRNA in VAT was significantly higher than in SAT in all groups. UCP1 mRNA in SAT was negatively correlated with BMI, total abdominal fat area, visceral fat area, blood pressure, fasting glucose, insulin, HOMA-IR score, triglyceride, hsCRP, fasting leptin levels, and adipocyte size. UCP1 mRNA in SAT was positively correlated with fasting adiponectin levels. UCP1 mRNA in VAT was negatively correlated with visceral-to-subcutaneous fat ratio (VSR), fasting glucose, and triglyceride levels. In SAT, UCP1 mRNA was negatively correlated with mRNA expression of leptin and CHOP, and positively correlated with mRNA expression of adiponectin. The expression of PRDM16 was positively correlated with UCP1 mRNA in both VAT and SAT. UCP1 mRNA expression in differentiated human white adipocytes was significantly reduced after incubation with thapsigargin, tunicamycin, homocysteine, TNF-alpha, or IL-beta, and significantly increased after incubation with exendin 4, dapagliflozin, and telmisartan.
+
+ CONCLUSIONS: This study demonstrated depot-specific mRNA expression of UCP1 and its association with obesity-related markers in human WAT. UCP1 mRNA in human white adipocytes was suppressed by inflammatory agents and enhanced by metabolic improvement agents. UCP1 in human WAT might participate in the pathogenesis of obesity-related metabolic diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Messenger). 0 (UCP1 protein, human). 0 (Uncoupling Protein 1).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1038%2fs41366-020-0528-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lim&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Depot-specific+UCP1+expression+in+human+white+adipose+tissue+and+its+association+with+obesity-related+markers.&volume=44&issue=3&spage=697&epage=706&date=2020&doi=10.1038%2Fs41366-020-0528-4&pmid=31965068&sid=OVID:medline
+
+<1465>
+Unique Identifier
+ 31963819
+Title
+ Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer's Like Pathology in Mice Brain.
+Source
+ Cells. 9(1), 2020 01 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hahm JR; Jo MH; Ullah R; Kim MW; Kim MO
+Authors Full Name
+ Hahm, Jong Ryeal; Jo, Myeung Hoon; Ullah, Rahat; Kim, Min Woo; Kim, Myeong Ok.
+Institution
+ Hahm, Jong Ryeal. Division of Endocrinology and Metabolism, Department of Internal Medicine, Gyeongsang National University Hospital and Institute of Health Sciences and Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju 52828, Korea.
+ Jo, Myeung Hoon. Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
+ Ullah, Rahat. Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
+ Kim, Min Woo. Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
+ Kim, Myeong Ok. Division of Life Sciences and Applied Life Science (BK 21plus), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea.
+MeSH Subject Headings
+ Adenylate Kinase/me [Metabolism]
+ Alzheimer Disease/co [Complications]
+ *Alzheimer Disease/me [Metabolism]
+ *Alzheimer Disease/pa [Pathology]
+ Amyloid/me [Metabolism]
+ Animals
+ *Antioxidants/me [Metabolism]
+ Astrocytes/me [Metabolism]
+ Astrocytes/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ *Brain/pa [Pathology]
+ Cognitive Dysfunction/co [Complications]
+ Diet, High-Fat
+ Inflammation/co [Complications]
+ Inflammation/pa [Pathology]
+ Insulin Resistance
+ Male
+ Memory Disorders/co [Complications]
+ Memory Disorders/pa [Pathology]
+ Mice, Inbred C57BL
+ Microglia/me [Metabolism]
+ Microglia/pa [Pathology]
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Oxidative Stress
+ Phosphorylation
+ *Receptors, Adiponectin/me [Metabolism]
+ Signal Transduction
+ *Stress, Physiological
+ Synapses/pa [Pathology]
+Keyword Heading
+ amyloid-beta
+ insulin resistance
+ neurodegeneration
+ neuroinflammation
+ obesity
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Oxidative stress and insulin resistance play major roles in numerous neurodegenerative diseases, including Alzheimer's disease (AD). A high-fat diet induces obesity-associated oxidative stress, neuronal insulin resistance, microglial activation, and neuroinflammation, which are considered important risk factors for neurodegeneration. Obesity-related metabolic dysfunction is a risk factor for cognitive decline. The present study aimed to elucidate whether chronic consumption of a high-fat diet (HFD; 24 weeks) can induce insulin resistance, neuroinflammation, and amyloid beta (Abeta) deposition in mouse brains. Male C57BL/6N mice were used for a high-fat diet (HFD)-induced pre-clinical model of obesity. The protein expression levels were examined via Western blot, immunofluorescence, and the behavior analysis was performed using the Morris water maze test. To obtain metabolic parameters, insulin sensitivity and glucose tolerance tests were performed. We found that metabolic perturbations from the chronic consumption of HFD elevated neuronal oxidative stress and insulin resistance through adiponectin receptor (AdipoR1) suppression in HFD-fed mice. Similarly, our in vitro results also indicated that knockdown of AdipoR1 in the embryonic mouse hippocampal cell line mHippoE-14 leads to increased oxidative stress in neurons. In addition, HFD markedly increased neuroinflammatory markers' glial activation in the cortex and hippocampus regions of HFD mouse brains. More importantly, we observed that AdipoR1 suppression increased the amyloidogenic pathway both in vivo and in vitro. Furthermore, deregulated synaptic proteins and behavioral deficits were observed in the HFD mouse brains. Taken together, our findings suggest that excessive consumption of an HFD has a profound impact on brain function, which involves the acceleration of cognitive impairment due to increased obesity-associated oxidative stress, insulin resistance, and neuroinflammation, which ultimately may cause early onset of Alzheimer's pathology via the suppression of AdipoR1 signaling in the brain.
+Registry Number/Name of Substance
+ 0 (Amyloid). 0 (Antioxidants). 0 (Biomarkers). 0 (Receptors, Adiponectin). EC 2-7-4-3 (Adenylate Kinase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fcells9010249
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hahm&issn=2073-4409&title=Cells&atitle=Metabolic+Stress+Alters+Antioxidant+Systems%2C+Suppresses+the+Adiponectin+Receptor+1+and+Induces+Alzheimer%27s+Like+Pathology+in+Mice+Brain.&volume=9&issue=1&spage=&epage=&date=2020&doi=10.3390%2Fcells9010249&pmid=31963819&sid=OVID:medline
+
+<1466>
+Unique Identifier
+ 31963377
+Title
+ Lack of Differences in Inflammation and T Cell-Mediated Function between Young and Older Women with Obesity.
+Source
+ Nutrients. 12(1), 2020 Jan 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dao MC; Saltzman E; Page M; Reece J; Mojtahed T; Wu D; Meydani SN
+Authors Full Name
+ Dao, Maria Carlota; Saltzman, Edward; Page, Melissa; Reece, Jillian; Mojtahed, Tara; Wu, Dayong; Meydani, Simin Nikbin.
+Institution
+ Dao, Maria Carlota. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
+ Saltzman, Edward. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
+ Page, Melissa. Weight and Wellness Center, Tufts Medical Center, Boston, MA 02111, USA.
+ Reece, Jillian. Weight and Wellness Center, Tufts Medical Center, Boston, MA 02111, USA.
+ Mojtahed, Tara. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
+ Wu, Dayong. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
+ Meydani, Simin Nikbin. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Aged
+ Aged, 80 and over
+ Aging/bl [Blood]
+ *Aging/im [Immunology]
+ Biomarkers/bl [Blood]
+ Cell Proliferation
+ Cells, Cultured
+ Cross-Sectional Studies
+ Cytokines/bl [Blood]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/im [Immunology]
+ Lymphocyte Activation
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/im [Immunology]
+ Pilot Projects
+ Sex Factors
+ *T-Lymphocytes/im [Immunology]
+ Young Adult
+Keyword Heading
+ T cell-mediated function
+ aging
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Both obesity and aging are associated with dysregulated immune and inflammatory responses. There is limited knowledge, however, on differences in the immune system between young and older adults with obesity. The goal of this study was to compare circulating inflammatory cytokines and T cell-mediated immune response between young and older women with obesity. Twenty-three young (23-43 years) and 21 older (60-83 years) women with obesity were recruited at the Weight and Wellness Center at Tufts Medical Center. Circulating inflammatory cytokines (CRP, IL-6, and IL-1beta) and ex vivo indicators of T cell-mediated immune function were compared between the groups. Older women with obesity had significantly fewer circulating CD3+, CD8+, CD19+, and natural killer T (NKT) cells compared to young women with obesity (p = 0.016, p < 0.0001, p = 0.0003, and p < 0.0001, respectively). However, with few exceptions, there was no significant difference in inflammation markers or stimulated lymphocyte proliferation and cytokine production by peripheral blood mononuclear cells between young and older participants. These findings are in contrast to those previously reported in young and old subjects with healthy weight and call for further investigation into the impact of obesity on premature aging of the immune system.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fnu12010237
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dao&issn=2072-6643&title=Nutrients&atitle=Lack+of+Differences+in+Inflammation+and+T+Cell-Mediated+Function+between+Young+and+Older+Women+with+Obesity.&volume=12&issue=1&spage=&epage=&date=2020&doi=10.3390%2Fnu12010237&pmid=31963377&sid=OVID:medline
+
+<1467>
+Unique Identifier
+ 31955604
+Title
+ The immune remodel: Weight loss-mediated inflammatory changes to obesity. [Review]
+Source
+ Experimental Biology & Medicine. 245(2):109-121, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Phillips CL; Grayson BE
+Author NameID
+ Grayson, Bernadette E; ORCID: https://orcid.org/0000-0002-1281-1682
+Authors Full Name
+ Phillips, Charles L; Grayson, Bernadette E.
+Institution
+ Phillips, Charles L. Program in Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
+ Grayson, Bernadette E. Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, USA.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Humans
+ *Inflammation/im [Immunology]
+ Inflammation/pa [Pathology]
+ Life Style
+ *Obesity/im [Immunology]
+ Up-Regulation
+ *Weight Loss/im [Immunology]
+Keyword Heading
+ Immune system
+ bariatric surgery
+ cytokine
+ inflammation
+ obesity
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, Non-P.H.S.. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1177%2f1535370219900185
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Phillips&issn=1535-3699&title=Experimental+Biology+%26+Medicine&atitle=The+immune+remodel%3A+Weight+loss-mediated+inflammatory+changes+to+obesity.&volume=245&issue=2&spage=109&epage=121&date=2020&doi=10.1177%2F1535370219900185&pmid=31955604&sid=OVID:medline
+
+<1468>
+Unique Identifier
+ 31954275
+Title
+ Salivary uric acid is a predictive marker of body fat percentage in adolescents.
+Source
+ Nutrition Research. 74:62-70, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Araujo DS; Scudine KGO; Pedroni-Pereira A; Gaviao MBD; Pereira EC; Fonseca FLA; Castelo PM
+Authors Full Name
+ Araujo, Darlle Santos; Scudine, Kelly Guedes de Oliveira; Pedroni-Pereira, Aline; Gaviao, Maria Beatriz Duarte; Pereira, Edimar Cristiano; Fonseca, Fernando Luiz Affonso; Castelo, Paula Midori.
+Institution
+ Araujo, Darlle Santos. Department of Pediatric Dentistry, Universidade Estadual de Campinas (UNICAMP), Av Limeira, 901, Piracicaba 13414-903, SP, Brazil.
+ Scudine, Kelly Guedes de Oliveira. Department of Pediatric Dentistry, Universidade Estadual de Campinas (UNICAMP), Av Limeira, 901, Piracicaba 13414-903, SP, Brazil.
+ Pedroni-Pereira, Aline. Department of Pediatric Dentistry, Universidade Estadual de Campinas (UNICAMP), Av Limeira, 901, Piracicaba 13414-903, SP, Brazil.
+ Gaviao, Maria Beatriz Duarte. Department of Pediatric Dentistry, Universidade Estadual de Campinas (UNICAMP), Av Limeira, 901, Piracicaba 13414-903, SP, Brazil.
+ Pereira, Edimar Cristiano. Department of Pharmaceutical Sciences, Universidade Federal de Sao Paulo (UNIFESP), R Sao Nicolau, 210, Diadema 09913-030, SP, Brazil.
+ Fonseca, Fernando Luiz Affonso. Department of Pharmaceutical Sciences, Universidade Federal de Sao Paulo (UNIFESP), R Sao Nicolau, 210, Diadema 09913-030, SP, Brazil.
+ Castelo, Paula Midori. Department of Pharmaceutical Sciences, Universidade Federal de Sao Paulo (UNIFESP), R Sao Nicolau, 210, Diadema 09913-030, SP, Brazil. Electronic address: paula.castelo@unifesp.br.
+MeSH Subject Headings
+ Adipose Tissue/pp [Physiopathology]
+ Adiposity
+ Adolescent
+ *Biomarkers/an [Analysis]
+ *Body Composition
+ Brazil
+ Cross-Sectional Studies
+ Female
+ Humans
+ Male
+ Obesity/pp [Physiopathology]
+ Overweight/pp [Physiopathology]
+ *Saliva/ch [Chemistry]
+ Sex Factors
+ *Uric Acid/an [Analysis]
+Keyword Heading
+ Adolescent
+ Lipids
+ Obesity
+ Saliva
+ Uric acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ As saliva showed to be a noninvasive source of markers useful to monitor clinical status, the hypothesis tested was that saliva may provide reliable markers able to predict the body fat accumulation in young subjects. The salivary characteristics of 248 adolescent scholars (119 girls; 14-17years) of flow rate, pH, phosphorus, urea, and calcium concentrations were assessed in stimulated saliva (colorimetric automated technique). The concentrations of cholesterol, 7-ketocholesterol, 25-hydroxyvitamin D2 and D3, and uric acid (UA) were measured with high-performance liquid chromatography in saliva collected at home (12-hour fast). Physical examination included height, weight, and body fat percentage (%BF) measured using bioelectric impedance to classify groups in below/above the %BF cutoff. Data were evaluated using 2-way analysis of variance and multiple linear regression. No significant difference was found in the levels of 25-hydroxyvitamin D2 and D3, cholesterol, 7-ketocholesterol, phosphorus, calcium, and urea between groups above and below %BF cutoff, and the variation in salivary flow was small. Significant sex and group effects were observed for salivary UA, which was increased in adolecents with higher %BF and in males (compared to females), without sex group interaction (power=99.8%). Sex showed a significant effect on salivary urea, with lower levels in females. A predictive model was obtained, with salivary UA and sex explaining the variation of %BF (P<.001; power=84%). Salivary UA showed to be an important marker of body fat accumulation in adolescents, demonstrating the clinical relevance of saliva to detect early changes and to monitor the nutritional status using a noninvasive and accurate method. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.nutres.2019.11.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Araujo&issn=0271-5317&title=Nutrition+Research&atitle=Salivary+uric+acid+is+a+predictive+marker+of+body+fat+percentage+in+adolescents.&volume=74&issue=&spage=62&epage=70&date=2020&doi=10.1016%2Fj.nutres.2019.11.007&pmid=31954275&sid=OVID:medline
+
+<1469>
+Unique Identifier
+ 31953742
+Title
+ Impact of Weight Loss on Inflammation State and Endothelial Markers Among Individuals with Extreme Obesity After Gastric Bypass Surgery: a 2-Year Follow-up Study.
+Source
+ Obesity Surgery. 30(5):1881-1890, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Farias G; Netto BDM; Boritza K; Bettini SC; Vilela RM; Damaso AR
+Author NameID
+ Farias, Gisele; ORCID: https://orcid.org/0000-0001-9145-7740
+Authors Full Name
+ Farias, Gisele; Netto, Barbara Dal Molin; Boritza, Katia; Bettini, Solange Cravo; Vilela, Regina Maria; Damaso, Ana Raimunda.
+Institution
+ Farias, Gisele. Gastrointestinal Surgery Service of Hospital de Clinicas, Federal University of Parana, UFPR, Rua General Carneiro, 81 - Centro, Curitiba, PR, 80060-900, Brazil. gisele.nutri.farias@gmail.com.
+ Netto, Barbara Dal Molin. Department of Nutrition, Federal University of Parana, UFPR, Curitiba, PR, Brazil.
+ Boritza, Katia. Biochemistry Section, Hospital de Clinicas - Universidade Federal do Parana, UFPR, Curitiba, PR, Brazil.
+ Bettini, Solange Cravo. Gastrointestinal Surgery Service of Hospital de Clinicas, Federal University of Parana, UFPR, Rua General Carneiro, 81 - Centro, Curitiba, PR, 80060-900, Brazil.
+ Vilela, Regina Maria. Department of Nutrition, Federal University of Parana, UFPR, Curitiba, PR, Brazil.
+ Damaso, Ana Raimunda. Nutrition Post Graduate Program, Universidade Federal de Sao Paulo - Escola Paulista de Medicina - UNIFESP-EPM. Nutrition Post Graduate Program, Sao Paulo, SP, Brazil.
+MeSH Subject Headings
+ Adiponectin
+ Adult
+ Biomarkers
+ Female
+ Follow-Up Studies
+ *Gastric Bypass
+ Humans
+ Inflammation
+ Leptin
+ Male
+ Obesity
+ Obesity, Morbid/su [Surgery]
+ *Obesity, Morbid
+ Weight Loss
+Keyword Heading
+ Bariatric surgery
+ Endothelial dysfunction
+ Inflammation
+ Obesity
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The medium-term impact of gastric bypass (GB) surgery on the inflammatory state and endothelial function of patients has yet to be confirmed.
+
+ OBJECTIVE: This study aims to elucidate the inflammatory profile and endothelial dysfunction response of adults with obesity 6 and 24 months after undergoing GB surgery.
+
+ METHODS: The anthropometric and biochemical markers of 32 adults with obesity (two men and 30 females) were collected preoperatively, and 6 and 24 months postoperatively.
+
+ RESULTS: Body mass index (BMI) and excess weight had decreased by 15.79 +/- 1.21 kg/m2 (p < 0.01) and 83.80 +/- 24.50% respectively at 24 months. Leptin, C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1) levels, and the leptin/adiponectin ratio decreased significantly at both postoperative follow-up points compared with preoperative values (p < 0.01). IL-6 and ICAM-1 levels decreased between 6 and 24 months post-GB (p < 0.01). IL-6 and ICAM-1 levels decreased between 6- and 24-months post-GB (p < 0.01). Resistin levels were significantly decreased (p < 0.01) at 6-month follow-up. The levels of the anti-inflammatory biomarkers IL-10, adiponectin, and the adiponectin/leptin ratio significantly increased postoperatively. There was an improvement in metabolic disorders after surgery.
+
+ CONCLUSION: Our results demonstrated that after GB there was an improvement in the inflammatory profile, identified by a reduction in pro-inflammatory markers (CRP, IL-6, leptin) and an increase in anti-inflammatory markers (adiponectin, IL-10). The decrease in PAI-1 and ICAM-1 levels may suggest improvement in endothelial function. These findings provide clear evidence of the medium-term impact of GB on inflammation state and a number of endothelial markers, and a consequent reduction in the risk of cardiovascular diseases.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs11695-020-04411-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Farias&issn=0960-8923&title=Obesity+Surgery&atitle=Impact+of+Weight+Loss+on+Inflammation+State+and+Endothelial+Markers+Among+Individuals+with+Extreme+Obesity+After+Gastric+Bypass+Surgery%3A+a+2-Year+Follow-up+Study.&volume=30&issue=5&spage=1881&epage=1890&date=2020&doi=10.1007%2Fs11695-020-04411-9&pmid=31953742&sid=OVID:medline
+
+<1470>
+Unique Identifier
+ 31950846
+Title
+ Abrogation of Toll-Like Receptor 4 Mitigates Obesity-Induced Oxidative Stress, Proinflammation, and Insulin Resistance Through Metabolic Reprogramming of Mitochondria in Adipose Tissue.
+Source
+ Antioxidants & Redox Signaling. 33(2):66-86, 2020 07 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lin HY; Weng SW; Shen FC; Chang YH; Lian WS; Hsieh CH; Chuang JH; Lin TK; Liou CW; Chang CS; Lin CY; Su YJ; Wang PW
+Authors Full Name
+ Lin, Hung-Yu; Weng, Shao-Wen; Shen, Feng-Chih; Chang, Yen-Hsiang; Lian, Wei-Shiung; Hsieh, Ching-Hua; Chuang, Jiin-Haur; Lin, Tsu-Kung; Liou, Chia-Wei; Chang, Chia-Shiang; Lin, Ching-Yi; Su, Yu-Jih; Wang, Pei-Wen.
+Institution
+ Lin, Hung-Yu. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Lin, Hung-Yu. Center for Mitochondrial Research and Medicine; Departments of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Weng, Shao-Wen. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Shen, Feng-Chih. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Chang, Yen-Hsiang. Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Lian, Wei-Shiung. Medical Research and Core Laboratory for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Lian, Wei-Shiung. Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Hsieh, Ching-Hua. Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Chuang, Jiin-Haur. Center for Mitochondrial Research and Medicine; Departments of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Chuang, Jiin-Haur. Pediatric Surgery, and Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Lin, Tsu-Kung. Center for Mitochondrial Research and Medicine; Departments of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Lin, Tsu-Kung. Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Liou, Chia-Wei. Center for Mitochondrial Research and Medicine; Departments of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Liou, Chia-Wei. Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Chang, Chia-Shiang. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Chang, Chia-Shiang. Center for Mitochondrial Research and Medicine; Departments of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Lin, Ching-Yi. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Lin, Ching-Yi. Center for Mitochondrial Research and Medicine; Departments of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Su, Yu-Jih. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Wang, Pei-Wen. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+ Wang, Pei-Wen. Center for Mitochondrial Research and Medicine; Departments of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Animals
+ Biomarkers
+ Disease Susceptibility
+ Immunity, Innate
+ Inflammation Mediators
+ *Insulin Resistance
+ Mice
+ *Mitochondria/me [Metabolism]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ *Oxidative Stress
+ *Toll-Like Receptor 4/ge [Genetics]
+ *Toll-Like Receptor 4/me [Metabolism]
+Keyword Heading
+ innate immunity
+ insulin resistance
+ mitochondrial ROS
+ oxidative stress
+ toll-like receptor 4
+ visceral fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aims: Obesity-induced excessive visceral fat (VF) accumulation is associated with insulin resistance (IR), systemic oxidative stress, and chronic inflammation. As toll-like receptor 4 (TLR4) plays an important role in innate immunity, we herein investigate the effect of TLR4 knockout (T4KO) in a high-fat high-sucrose diet (HFD)-induced obesity mouse model. Results: C57BL6 wild-type (WT) and T4KO mice were fed with either control diet (CD) or HFD for 12 months, rendering four experimental groups: WT+CD, WT+HFD, T4KO+CD, and T4KO+HFD. Compared with WT+CD, WT+HFD demonstrated significant increase in VF accumulation, oxidative damage, M1/M2 macrophage ratio, chronic inflammation, and development of IR. Compared with WT+HFD, T4KO+HFD presented increased BW and body fat with higher subcutaneous fat (SF)/VF ratio, but lower body temperature, as well as decreased oxidative damage, M1/M2 macrophage ratio, chronic inflammation, and IR. Unlike WT+HFD, T4KO+HFD exhibited an increase in mitochondrial electron transport chain activity but a decrease of uncoupling protein 2 (UCP2) level. While T4KO hindered HFD-induced increasing mitochondrial oxygen consumption rate, a shift toward a higher extracellular acidification rate in VF was observed. Notably, T4KO inhibits HFD-induced mitochondrial translocation of nuclear factor of activated T cells 2 (NFATC2), which contributed to mitochondrial metabolic reprogramming. Both fat distribution shifting from VF to SF and mitochondrial metabolic reprogramming may alleviate systemic oxidative stress and chronic inflammation. Innovation and Conclusion: Abrogation of TLR4 contributes to reduction of oxidative stress through metabolic reprogramming of mitochondria in VF, mitigating obesity-induced IR. The study provides critical insight into associating innate immunity-mitochondria interplay with prevention of diabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Toll-Like Receptor 4).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1089%2fars.2019.7737
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lin&issn=1523-0864&title=Antioxidants+%26+Redox+Signaling&atitle=Abrogation+of+Toll-Like+Receptor+4+Mitigates+Obesity-Induced+Oxidative+Stress%2C+Proinflammation%2C+and+Insulin+Resistance+Through+Metabolic+Reprogramming+of+Mitochondria+in+Adipose+Tissue.&volume=33&issue=2&spage=66&epage=86&date=2020&doi=10.1089%2Fars.2019.7737&pmid=31950846&sid=OVID:medline
+
+<1471>
+Unique Identifier
+ 31947687
+Title
+ Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences. [Review]
+Source
+ International Journal of Molecular Sciences. 21(2), 2020 Jan 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Barabas K; Szabo-Meleg E; Abraham IM
+Authors Full Name
+ Barabas, Klaudia; Szabo-Meleg, Edina; Abraham, Istvan M.
+Institution
+ Barabas, Klaudia. Molecular Neuroendocrinology Research Group, Institute of Physiology, Medical School, Centre for Neuroscience, Szentagothai Research Institute, University of Pecs, H-7624 Pecs, Hungary.
+ Szabo-Meleg, Edina. Departement of Biophysics, Medical School, University of Pecs; H-7624 Pecs, Hungary.
+ Abraham, Istvan M. Molecular Neuroendocrinology Research Group, Institute of Physiology, Medical School, Centre for Neuroscience, Szentagothai Research Institute, University of Pecs, H-7624 Pecs, Hungary.
+MeSH Subject Headings
+ Aging/ge [Genetics]
+ Aging/im [Immunology]
+ Aging/me [Metabolism]
+ Animals
+ Astrocytes/me [Metabolism]
+ Biomarkers
+ Blood-Brain Barrier/me [Metabolism]
+ *Cytokines/me [Metabolism]
+ Estradiol/me [Metabolism]
+ Feedback, Physiological
+ Female
+ Fertility/ge [Genetics]
+ *Gonadotropin-Releasing Hormone/bi [Biosynthesis]
+ Gonadotropin-Releasing Hormone/ge [Genetics]
+ Humans
+ Inflammation/et [Etiology]
+ *Inflammation/me [Metabolism]
+ Kisspeptins/ge [Genetics]
+ Kisspeptins/me [Metabolism]
+ Lipopolysaccharides/im [Immunology]
+ Microglia/me [Metabolism]
+ *Neurons/me [Metabolism]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Reproduction/ge [Genetics]
+ Reproduction/im [Immunology]
+ *Signal Transduction
+Keyword Heading
+ GnRH neuron
+ cytokines
+ estradiol
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ : Inflammation has a well-known suppressive effect on fertility. The function of gonadotropin-releasing hormone (GnRH) neurons, the central regulator of fertility is substantially altered during inflammation in females. In our review we discuss the latest results on how the function of GnRH neurons is modified by inflammation in females. We first address the various effects of inflammation on GnRH neurons and their functional consequences. Second, we survey the possible mechanisms underlying the inflammation-induced actions on GnRH neurons. The role of several factors will be discerned in transmitting inflammatory signals to the GnRH neurons: cytokines, kisspeptin, RFamide-related peptides, estradiol and the anti-inflammatory cholinergic pathway. Since aging and obesity are both characterized by reproductive decline our review also focuses on the mechanisms and pathophysiological consequences of the impact of inflammation on GnRH neurons in aging and obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Kisspeptins). 0 (Lipopolysaccharides). 33515-09-2 (Gonadotropin-Releasing Hormone). 4TI98Z838E (Estradiol).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.3390%2fijms21020529
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Barabas&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Effect+of+Inflammation+on+Female+Gonadotropin-Releasing+Hormone+%28GnRH%29+Neurons%3A+Mechanisms+and+Consequences.&volume=21&issue=2&spage=529&epage=&date=2020&doi=10.3390%2Fijms21020529&pmid=31947687&sid=OVID:medline
+
+<1472>
+Unique Identifier
+ 31944871
+Title
+ Low Serum Interleukin-6 Is a Differential Marker of Obesity-Related Metabolic Dysfunction in Women and Men.
+Source
+ Journal of Interferon & Cytokine Research. 40(3):131-138, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mendez-Garcia LA; Cid-Soto M; Aguayo-Guerrero JA; Carrero-Aguirre M; Trejo-Millan F; Islas-Andrade S; Fragoso JM; Olivos-Garcia A; Escobedo G
+Authors Full Name
+ Mendez-Garcia, Lucia A; Cid-Soto, Miguel; Aguayo-Guerrero, Jose A; Carrero-Aguirre, Miguel; Trejo-Millan, Fernanda; Islas-Andrade, Sergio; Fragoso, Jose M; Olivos-Garcia, Alfonso; Escobedo, Galileo.
+Institution
+ Mendez-Garcia, Lucia A. Laboratory for Proteomics and Metabolomics, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga," Mexico City, Mexico.
+ Cid-Soto, Miguel. Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genomica, SS, Mexico City, Mexico.
+ Aguayo-Guerrero, Jose A. Laboratory for Proteomics and Metabolomics, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga," Mexico City, Mexico.
+ Carrero-Aguirre, Miguel. Laboratory for Proteomics and Metabolomics, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga," Mexico City, Mexico.
+ Trejo-Millan, Fernanda. Laboratory for Proteomics and Metabolomics, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga," Mexico City, Mexico.
+ Islas-Andrade, Sergio. Laboratory for Proteomics and Metabolomics, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga," Mexico City, Mexico.
+ Fragoso, Jose M. Department of Molecular Biology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico.
+ Olivos-Garcia, Alfonso. Unit of Experimental Medicine, School of Medicine, Universidad Nacional Autonoma de Mexico, General Hospital of Mexico "Dr. Eduardo Liceaga," Mexico City, Mexico.
+ Escobedo, Galileo. Laboratory for Proteomics and Metabolomics, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga," Mexico City, Mexico.
+MeSH Subject Headings
+ Adult
+ *Biomarkers
+ Blood Glucose
+ Body Weights and Measures
+ Cytokines/bl [Blood]
+ Female
+ Humans
+ Insulin/me [Metabolism]
+ Insulin Resistance
+ *Interleukin-6/bl [Blood]
+ Male
+ Metabolic Diseases/di [Diagnosis]
+ *Metabolic Diseases/et [Etiology]
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Young Adult
+Keyword Heading
+ TNF-alpha
+ glucose
+ interleukin-10
+ interleukin-6
+ triglycerides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ There is scant information regarding the role of interleukin (IL)-6 in obesity-related metabolic dysfunction in humans. Thus, we studied the serum levels of IL-6 in normal weight, overweight, and obese subjects, and examined associations of IL-6 with hyperglycemia, insulin resistance, dyslipidemia, and systemic inflammation. One hundred three women and men were included in the study. Anthropometric parameters, blood glucose, insulin, total cholesterol, and triglycerides were measured. Serum levels of tumor necrosis factor-alpha (TNF-alpha), IL-10, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). One-way analysis of variance (ANOVA) showed a 2.5-fold significant decrease in serum IL-6 in overweight and obese individuals when compared with normal weight controls. Serum IL-6 exhibited significant inverse correlations with body mass index (r = -0.39/P < 0.0001), waist circumference (r = -0.42/P < 0.001), blood glucose (r = -0.40/P < 0.0001), triglycerides (r = -0.34/P < 0.0001), and TNF-alpha (r = -0.48/P < 0.0001), whereas a strongly positive correlation was found with IL-10 (r = 0.77/P < 0.0001). Multiple linear regression analysis revealed that behavior of IL-6 was mainly influenced by IL-10 (beta = 0.28/P = 1.95 x 10-6), TNF-alpha (beta = -0.67/P = 0.0017), and body fat percentage (beta = -5.95/P = 7.67 x 10-5) in women. In contrast, IL-10 (beta = 0.37/P = 1.34 x 10-9), TNF-alpha (beta = -0.85/P = 0.0005), and triglycerides (beta = 1.07/P = 0.0007) were major influencing factors of IL-6 in men. This study demonstrates that IL-6 is a marker of metabolic dysfunction that is differentially regulated in obese women and men. [Figure: see text].
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cytokines). 0 (Insulin). 0 (Interleukin-6).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1089%2fjir.2019.0149
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mendez-Garcia&issn=1079-9907&title=Journal+of+Interferon+%26+Cytokine+Research&atitle=Low+Serum+Interleukin-6+Is+a+Differential+Marker+of+Obesity-Related+Metabolic+Dysfunction+in+Women+and+Men.&volume=40&issue=3&spage=131&epage=138&date=2020&doi=10.1089%2Fjir.2019.0149&pmid=31944871&sid=OVID:medline
+
+<1473>
+Unique Identifier
+ 31928513
+Title
+ Logistic LASSO and Elastic Net to Characterize Vitamin D Deficiency in a Hypertensive Obese Population.
+Source
+ Metabolic Syndrome & Related Disorders. 18(2):79-85, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Garcia-Carretero R; Vigil-Medina L; Barquero-Perez O; Mora-Jimenez I; Soguero-Ruiz C; Goya-Esteban R; Ramos-Lopez J
+Authors Full Name
+ Garcia-Carretero, Rafael; Vigil-Medina, Luis; Barquero-Perez, Oscar; Mora-Jimenez, Inmaculada; Soguero-Ruiz, Cristina; Goya-Esteban, Rebeca; Ramos-Lopez, Javier.
+Institution
+ Garcia-Carretero, Rafael. Department of Internal Medicine, Mostoles University Hospital, Rey Juan Carlos University, Mostoles, Spain.
+ Vigil-Medina, Luis. Department of Internal Medicine, Mostoles University Hospital, Rey Juan Carlos University, Mostoles, Spain.
+ Barquero-Perez, Oscar. Department of Signal Theory and Communications and Telematics Systems and Computing, Rey Juan Carlos University, Fuenlabrada, Spain.
+ Mora-Jimenez, Inmaculada. Department of Signal Theory and Communications and Telematics Systems and Computing, Rey Juan Carlos University, Fuenlabrada, Spain.
+ Soguero-Ruiz, Cristina. Department of Signal Theory and Communications and Telematics Systems and Computing, Rey Juan Carlos University, Fuenlabrada, Spain.
+ Goya-Esteban, Rebeca. Department of Signal Theory and Communications and Telematics Systems and Computing, Rey Juan Carlos University, Fuenlabrada, Spain.
+ Ramos-Lopez, Javier. Department of Signal Theory and Communications and Telematics Systems and Computing, Rey Juan Carlos University, Fuenlabrada, Spain.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ *Data Mining
+ Electronic Health Records
+ Female
+ Humans
+ Hypertension/bl [Blood]
+ *Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ Logistic Models
+ Machine Learning
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ Spain/ep [Epidemiology]
+ Vitamin D Deficiency/bl [Blood]
+ *Vitamin D Deficiency/di [Diagnosis]
+ Vitamin D Deficiency/ep [Epidemiology]
+Keyword Heading
+ metabolic syndrome
+ obesity
+ penalized regression
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Aim: The primary objective of our research was to compare the performance of data analysis to predict vitamin D deficiency using three different regression approaches and to evaluate the usefulness of incorporating machine learning algorithms into the data analysis in a clinical setting. Methods: We included 221 patients from our hypertension unit, whose data were collected from electronic records dated between 2006 and 2017. We used classical stepwise logistic regression, and two machine learning methods [least absolute shrinkage and selection operator (LASSO) and elastic net]. We assessed the performance of these three algorithms in terms of sensitivity, specificity, misclassification error, and area under the curve (AUC). Results: LASSO and elastic net regression performed better than logistic regression in terms of AUC, which was significantly better in both penalized methods, with AUC = 0.76 and AUC = 0.74 for elastic net and LASSO, respectively, than in logistic regression, with AUC = 0.64. In terms of misclassification rate, elastic net (18%) outperformed LASSO (22%) and logistic regression (25%). Conclusion: Compared with a classical logistic regression approach, penalized methods were found to have better performance in predicting vitamin D deficiency. The use of machine learning algorithms such as LASSO and elastic net may significantly improve the prediction of vitamin D deficiency in a hypertensive obese population.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1089%2fmet.2019.0104
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Garcia-Carretero&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Logistic+LASSO+and+Elastic+Net+to+Characterize+Vitamin+D+Deficiency+in+a+Hypertensive+Obese+Population.&volume=18&issue=2&spage=79&epage=85&date=2020&doi=10.1089%2Fmet.2019.0104&pmid=31928513&sid=OVID:medline
+
+<1474>
+Unique Identifier
+ 31926078
+Title
+ Machine learning as new promising technique for selection of significant features in obese women with type 2 diabetes.
+Source
+ Hormone Molecular Biology & Clinical Investigation. 41(1), 2020 Jan 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lotfi H; Pirmoradi S; Mahmoudi R; Teshnehlab M; Sheervalilou R; Fekri Aval S; Zarghami N
+Author NameID
+ Zarghami, Nosratollah; ORCID: https://orcid.org/0000-0002-4236-4537
+Authors Full Name
+ Lotfi, Hajie; Pirmoradi, Saeed; Mahmoudi, Rasoul; Teshnehlab, Mohammad; Sheervalilou, Roghayeh; Fekri Aval, Sedigheh; Zarghami, Nosratollah.
+Institution
+ Lotfi, Hajie. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Lotfi, Hajie. Infectious and Tropical Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Pirmoradi, Saeed. Department of Computer Engineering, Science and Research Branch Islamic Azad University, Tehran, Iran.
+ Mahmoudi, Rasoul. Infectious and Tropical Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Teshnehlab, Mohammad. Department of Control Engineering, K.N.Toosi University of Technology, Tahran, Iran.
+ Sheervalilou, Roghayeh. Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
+ Fekri Aval, Sedigheh. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Zarghami, Nosratollah. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Zarghami, Nosratollah. Department of Clinical Biochemistry and Laboratory Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Phone: +989143043710, Fax: +984133355788.
+MeSH Subject Headings
+ Adiponectin/an [Analysis]
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Female
+ Hemoglobins/an [Analysis]
+ Humans
+ Insulin/an [Analysis]
+ *Machine Learning
+ Nicotinamide Phosphoribosyltransferase/an [Analysis]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+Keyword Heading
+ adipocytokines
+ artificial neural network
+ diabetic women
+ machine learning
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background The global trend of obesity and diabetes is considerable. Recently, the early diagnosis and accurate prediction of type 2 diabetes mellitus (T2DM) patients have been planned to be estimated according to precise and reliable methods, artificial networks and machine learning (ML). Materials and methods In this study, an experimental data set of relevant features (adipocytokines and anthropometric levels) obtained from obese women (diabetic and non-diabetic) was analyzed. Machine learning was used to select significant features [by the separability-correlation measure (SCM) algorithm] for classification of women with the best accuracy and the results were evaluated using an artificial neural network (ANN). Results According to the experimental data analysis, a significant difference (p < 0.05) was found between fasting blood sugar (FBS), hemoglobin A1c (HbA1c) and visfatin level in two groups. Moreover, significant correlations were determined between HbA1c and FBS, homeostatic model assessment (HOMA) and insulin, total cholesterol (TC) level and body mass index (BMI) in non-diabetic women and insulin and HOMA, FBS and HbA1c, insulin and HOMA, systolic blood pressure (SBP) and diastolic blood pressure (DBP), BMI and TC and HbA1c and TC in the diabetic group. Furthermore, there were significant positive correlations between adipocytokines except for the resistin and leptin levels for both groups. The excellent (FBS and HbA1c), good (HOMA) and fair (visfatin, adiponectin and insulin) discriminators of diabetic women were determined based on specificities and sensitivities level. The more selected features in the ML method were FBS, apelin, visfatin, TC, HbA1c and adiponectin. Conclusions Thus, the subset of features involving FBS, apelin, visfatin and HbA1c are significant features and make the best discrimination between groups. In this study, based on statistical and ML results, the useful biomarkers for discrimination of diabetic women were FBS, HbA1c, HOMA, insulin, visfatin, adiponectin and apelin. Eventually, we designed useful software for identification of T2DM and the healthy population to be utilized in clinical diagnosis.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Hemoglobins). 0 (Insulin). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1515%2fhmbci-2019-0019
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lotfi&issn=1868-1883&title=Hormone+Molecular+Biology+%26+Clinical+Investigation&atitle=Machine+learning+as+new+promising+technique+for+selection+of+significant+features+in+obese+women+with+type+2+diabetes.&volume=41&issue=1&spage=&epage=&date=2020&doi=10.1515%2Fhmbci-2019-0019&pmid=31926078&sid=OVID:medline
+
+<1475>
+Unique Identifier
+ 31917095
+Title
+ Microvesicles and exosomes in metabolic diseases and inflammation. [Review]
+Source
+ Cytokine & Growth Factor Reviews. 51:27-39, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dini L; Tacconi S; Carata E; Tata AM; Vergallo C; Panzarini E
+Authors Full Name
+ Dini, L; Tacconi, S; Carata, E; Tata, A M; Vergallo, C; Panzarini, E.
+Institution
+ Dini, L. Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Rome, Italy; CNR-Nanotec, Lecce, Italy. Electronic address: luciana.dini@uniroma1.it.
+ Tacconi, S. Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy.
+ Carata, E. Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy.
+ Tata, A M. Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Rome, Italy; Research Center in Neurobiology "Daniel Bovet, Sapienza University of Rome, Rome, Italy.
+ Vergallo, C. Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy.
+ Panzarini, E. Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy. Electronic address: elisa.panzarini@unisalento.it.
+MeSH Subject Headings
+ Adipocytes/ph [Physiology]
+ Animals
+ Biomarkers
+ *Cell Communication
+ *Exosomes/ph [Physiology]
+ *Extracellular Vesicles/ph [Physiology]
+ Humans
+ *Inflammation/pp [Physiopathology]
+ Macrophages
+ *Metabolic Syndrome/pp [Physiopathology]
+ Mice
+ Obesity/pp [Physiopathology]
+Keyword Heading
+ Extracellular vesicles
+ Inflammation
+ M1 macrophages
+ M2 macrophages
+ Metabolic disorders
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Metabolic diseases are based on a dysregulated crosstalk between various cells such as adipocytes, hepatocytes and immune cells. Generally, hormones and metabolites mediate this crosstalk that becomes alterated in metabolic syndrome including obesity and diabetes. Recently, Extracellular Vesicles (EVs) are emerging as a novel way of cell-to-cell communication and represent an attractive strategy to transfer fundamental informations between the cells through the transport of proteins and nucleic acids. EVs, released in the extracellular space, circulate via the various body fluids and modulate the cellular responses following their interaction with the near and far target cells. Clinical and experimental data support their role as biomarkers and bioeffectors in several diseases includimg also the metabolic syndrome. Despite numerous studies on the role of macrophages in the development of metabolic diseases, to date, there are little informations about the influence of metabolic stress on the EVs produced by macrophages and about the role of the released vesicles in the organism. Here, we review current understanding about the role of EVs in metabolic diseases, mainly in inflammation status burst. This knowledge may play a relevant role in health monitoring, medical diagnosis and personalized medicine. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.cytogfr.2019.12.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dini&issn=1359-6101&title=Cytokine+%26+Growth+Factor+Reviews&atitle=Microvesicles+and+exosomes+in+metabolic+diseases+and+inflammation.&volume=51&issue=&spage=27&epage=39&date=2020&doi=10.1016%2Fj.cytogfr.2019.12.008&pmid=31917095&sid=OVID:medline
+
+<1476>
+Unique Identifier
+ 31915893
+Title
+ Cord blood metabolic markers are strong mediators of the effect of maternal adiposity on fetal growth in pregnancies across the glucose tolerance spectrum: the PANDORA study.
+Source
+ Diabetologia. 63(3):497-507, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee IL; Barr ELM; Longmore D; Barzi F; Brown ADH; Connors C; Boyle JA; Kirkwood M; Hampton V; Lynch M; Lu ZX; O'Dea K; Oats J; McIntyre HD; Zimmet P; Shaw JE; Maple-Brown LJ
+Corporate Author
+ PANDORA study team
+Authors Full Name
+ Lee, I-Lynn; Barr, Elizabeth L M; Longmore, Danielle; Barzi, Federica; Brown, Alex D H; Connors, Christine; Boyle, Jacqueline A; Kirkwood, Marie; Hampton, Vanya; Lynch, Michael; Lu, Zhong X; O'Dea, Kerin; Oats, Jeremy; McIntyre, H David; Zimmet, Paul; Shaw, Jonathan E; Maple-Brown, Louise J.
+Institution
+ Lee, I-Lynn. Wellbeing and Preventable Chronic Disease Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT, 0811, Australia.
+ Barr, Elizabeth L M. Wellbeing and Preventable Chronic Disease Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT, 0811, Australia.
+ Barr, Elizabeth L M. Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
+ Longmore, Danielle. Wellbeing and Preventable Chronic Disease Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT, 0811, Australia.
+ Barzi, Federica. Wellbeing and Preventable Chronic Disease Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT, 0811, Australia.
+ Brown, Alex D H. South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
+ Brown, Alex D H. Faculty of Health and Medical Sciences, the University of Adelaide, Adelaide, SA, Australia.
+ Connors, Christine. Northern Territory Department of Health, Darwin, NT, Australia.
+ Boyle, Jacqueline A. Monash Centre for Health Research and Implementation, School of Public Health and Preventative Medicine, Monash University, Clayton, VIC, Australia.
+ Kirkwood, Marie. Wellbeing and Preventable Chronic Disease Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT, 0811, Australia.
+ Hampton, Vanya. Wellbeing and Preventable Chronic Disease Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT, 0811, Australia.
+ Lynch, Michael. Pathology Network, Top End Health and Hospital Services, Darwin, NT, Australia.
+ Lu, Zhong X. Monash Pathology, Monash Health, Melbourne, VIC, Australia.
+ Lu, Zhong X. Department of Medicine, Monash University, Melbourne, VIC, Australia.
+ O'Dea, Kerin. School of Health Sciences, University of South Australia, Adelaide, SA, Australia.
+ Oats, Jeremy. Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
+ McIntyre, H David. Mater Medical Research Institute, University of Queensland, Brisbane, QLD, Australia.
+ Zimmet, Paul. Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.
+ Shaw, Jonathan E. Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
+ Maple-Brown, Louise J. Wellbeing and Preventable Chronic Disease Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT, 0811, Australia. Louise.Maple-Brown@menzies.edu.au.
+ Maple-Brown, Louise J. Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia. Louise.Maple-Brown@menzies.edu.au.
+MeSH Subject Headings
+ *Adiposity/ph [Physiology]
+ Adult
+ Australia/ep [Epidemiology]
+ Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ Birth Weight/ph [Physiology]
+ Body Mass Index
+ Cohort Studies
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/ep [Epidemiology]
+ Diabetes, Gestational/me [Metabolism]
+ Female
+ *Fetal Blood/me [Metabolism]
+ *Fetal Development/ph [Physiology]
+ *Glucose/me [Metabolism]
+ Glucose Intolerance/di [Diagnosis]
+ Glucose Intolerance/ep [Epidemiology]
+ Glucose Intolerance/me [Metabolism]
+ Humans
+ Hyperglycemia/di [Diagnosis]
+ Hyperglycemia/ep [Epidemiology]
+ Hyperglycemia/me [Metabolism]
+ Infant, Newborn
+ Male
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Pregnancy
+ Pregnancy Complications/di [Diagnosis]
+ Pregnancy Complications/ep [Epidemiology]
+ *Pregnancy Complications/me [Metabolism]
+ Pregnancy Outcome/ep [Epidemiology]
+ Pregnancy in Diabetics/di [Diagnosis]
+ Pregnancy in Diabetics/ep [Epidemiology]
+ Pregnancy in Diabetics/me [Metabolism]
+ Prognosis
+ Young Adult
+Keyword Heading
+ Cord blood
+ Diabetes in pregnancy
+ Fetal hyperinsulinaemia
+ Gestational diabetes
+ Neonatal adiposity
+ Neonatal fat mass
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/HYPOTHESIS: We aimed to assess associations between cord blood metabolic markers and fetal overgrowth, and whether cord markers mediated the impact of maternal adiposity on neonatal anthropometric outcomes among children born to Indigenous and Non-Indigenous Australian women with normal glucose tolerance (NGT), gestational diabetes mellitus (GDM) and pregestational type 2 diabetes mellitus.
+
+ METHODS: From the Pregnancy and Neonatal Outcomes in Remote Australia (PANDORA) study, an observational cohort of 1135 mother-baby pairs, venous cord blood was available for 645 singleton babies (49% Indigenous Australian) of women with NGT (n = 129), GDM (n = 419) and type 2 diabetes (n = 97). Cord glucose, triacylglycerol, HDL-cholesterol, C-reactive protein (CRP) and C-peptide were measured. Multivariable logistic and linear regression were used to assess the associations between cord blood metabolic markers and the outcomes of birthweight z score, sum of skinfold thickness (SSF), being large for gestational age (LGA) and percentage of body fat. Pathway analysis assessed whether cord markers mediated the associations between maternal and neonatal adiposity.
+
+ RESULTS: Elevated cord C-peptide was significantly associated with increasing birthweight z score (beta 0.57 [95% CI 0.42, 0.71]), SSF (beta 0.83 [95% CI 0.41, 1.25]), percentage of body fat (beta 1.20 [95% CI 0.69, 1.71]) and risk for LGA [OR 3.14 [95% CI 2.11, 4.68]), after adjusting for age, ethnicity and diabetes type. Cord triacylglycerol was negatively associated with birthweight z score for Indigenous Australian women only. No associations between cord glucose, HDL-cholesterol and CRP >0.3 mg/l (2.9 nmol/l) with neonatal outcomes were observed. C-peptide mediated 18% (95% CI 13, 36) of the association of maternal BMI with LGA and 11% (95% CI 8, 17) of the association with per cent neonatal fat.
+
+ CONCLUSIONS/INTERPRETATION: Cord blood C-peptide is an important mediator of the association between maternal and infant adiposity, across the spectrum of maternal glucose tolerance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs00125-019-05079-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=0012-186X&title=Diabetologia&atitle=Cord+blood+metabolic+markers+are+strong+mediators+of+the+effect+of+maternal+adiposity+on+fetal+growth+in+pregnancies+across+the+glucose+tolerance+spectrum%3A+the+PANDORA+study.&volume=63&issue=3&spage=497&epage=507&date=2020&doi=10.1007%2Fs00125-019-05079-2&pmid=31915893&sid=OVID:medline
+
+<1477>
+Unique Identifier
+ 31909493
+Title
+ GQ-130, a novel analogue of thiazolidinedione, improves obesity-induced metabolic alterations in rats: Evidence for the involvement of PPARbeta/delta pathway.
+Source
+ Clinical & Experimental Pharmacology & Physiology. 47(5):798-808, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Silva OA; Ribeiro-Filho HV; Avelino TM; Tittanegro TH; Figueira ACM; Rabelo LA; Pitta IDR; Lahlou S; Duarte GP
+Author NameID
+ Lahlou, Saad; ORCID: https://orcid.org/0000-0002-9070-5009
+ Duarte, Gloria Pinto; ORCID: https://orcid.org/0000-0003-3971-7976
+Authors Full Name
+ Silva, Odair Alves; Ribeiro-Filho, Helder Veras; Avelino, Thayna Mendonca; Tittanegro, Thais Helena; Figueira, Ana Carolina Migliorini; Rabelo, Luiza Antas; Pitta, Ivan da Rocha; Lahlou, Saad; Duarte, Gloria Pinto.
+Institution
+ Silva, Odair Alves. Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
+ Ribeiro-Filho, Helder Veras. National Institute of Biosciences, Brazilian Association for Synchrotron Light Technology, Campinas, Sao Paulo, Brazil.
+ Avelino, Thayna Mendonca. National Institute of Biosciences, Brazilian Association for Synchrotron Light Technology, Campinas, Sao Paulo, Brazil.
+ Tittanegro, Thais Helena. National Institute of Biosciences, Brazilian Association for Synchrotron Light Technology, Campinas, Sao Paulo, Brazil.
+ Figueira, Ana Carolina Migliorini. National Institute of Biosciences, Brazilian Association for Synchrotron Light Technology, Campinas, Sao Paulo, Brazil.
+ Rabelo, Luiza Antas. Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio, Brazil.
+ Pitta, Ivan da Rocha. Core of Therapeutic Innovation, Federal University of Pernambuco, Recife, Brazil.
+ Lahlou, Saad. Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Fortaleza, Brazil.
+ Duarte, Gloria Pinto. Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Pressure/de [Drug Effects]
+ Disease Models, Animal
+ *Energy Metabolism/de [Drug Effects]
+ HEK293 Cells
+ Humans
+ Insulin Resistance
+ Male
+ *Metabolic Syndrome/dt [Drug Therapy]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/co [Complications]
+ *Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ *PPAR delta/ag [Agonists]
+ PPAR delta/ge [Genetics]
+ PPAR delta/me [Metabolism]
+ *PPAR-beta/ag [Agonists]
+ PPAR-beta/ge [Genetics]
+ PPAR-beta/me [Metabolism]
+ Rats, Wistar
+ Signal Transduction
+ *Thiazolidinediones/pd [Pharmacology]
+ Time Factors
+Keyword Heading
+ GQ-130
+ PPARbeta/delta
+ high-fat diet
+ metabolic syndrome
+ thiazolidinediones
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The present investigation aimed to characterize the effect of a short-time treatment with a new thiazolidinedione (TZD) derivative, GQ-130, on metabolic alterations in rats fed a high-fat diet (HFD). We investigated whether metabolic alterations induced by GQ-130 were mediated though a mechanism that involves PPARbeta/delta transactivation. Potential binding and transactivation of PPARalpha, PPARbeta/delta or PPARgamma by GQ-130 were examined through cell transactivation, 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence quenching assays and thermal shift assay. For in vivo experiments, male 8-week-old Wistar rats were divided into three groups fed for 6 weeks with: (a) a standard rat chow (14% fat) (control group), (b) a HFD (57.8% fat) alone (HFD group), or (c) a HFD associated with an oral treatment with GQ-130 (10 mg/kg/d) during the last week (HFD-GQ group). In 293T cells, unlike rosiglitazone, GQ-130 did not cause significant transactivation of PPARgamma but was able to activate PPARbeta/delta by 153.9 folds in comparison with control values (DMSO). Surprisingly, ANS fluorescence quenching assay reveals that GQ-130 does not bind directly to PPARbeta/delta binding site, a finding that was further corroborated by thermal shift assay which evaluates the thermal stability of PPARbeta/delta in the presence of GQ-130. Compared to the control group, rats of the HFD group showed obesity, increased systolic blood pressure (SBP), insulin resistance, impaired glucose intolerance, hyperglycaemia, and dyslipidaemia. GQ-130 treatment abolished the increased SBP and improved all metabolic dysfunctions observed in the HFD group. Oral treatment with GQ-130 was effective in improving HFD-induced metabolic alterations probably through a mechanism that involves PPARbeta/delta activation. Copyright © 2020 John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (PPAR delta). 0 (PPAR-beta). 0 (Thiazolidinediones).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2f1440-1681.13252
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Silva&issn=0305-1870&title=Clinical+%26+Experimental+Pharmacology+%26+Physiology&atitle=GQ-130%2C+a+novel+analogue+of+thiazolidinedione%2C+improves+obesity-induced+metabolic+alterations+in+rats%3A+Evidence+for+the+involvement+of+PPARbeta%2Fdelta+pathway.&volume=47&issue=5&spage=798&epage=808&date=2020&doi=10.1111%2F1440-1681.13252&pmid=31909493&sid=OVID:medline
+
+<1478>
+Unique Identifier
+ 31906923
+Title
+ Understanding the impact of five major determinants of health (genetics, biology, behavior, psychology, society/environment) on type 2 diabetes in U.S. Hispanic/Latino families: Mil Familias - a cohort study.
+Source
+ BMC Endocrine Disorders. 20(1):4, 2020 Jan 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Morales J; Glantz N; Larez A; Bevier W; Conneely M; Fan L; Reed B; Alatorre C; Paczkowski R; Ahmed T; Mackenzie A; Duncan I; Kerr D
+Authors Full Name
+ Morales, Jessikah; Glantz, Namino; Larez, Arianna; Bevier, Wendy; Conneely, Mary; Fan, Ludi; Reed, Beverly; Alatorre, Carlos; Paczkowski, Rosirene; Ahmed, Tamim; Mackenzie, Andrew; Duncan, Ian; Kerr, David.
+Institution
+ Morales, Jessikah. Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA, 93105, USA. jmorales@sansum.org.
+ Glantz, Namino. Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA, 93105, USA.
+ Larez, Arianna. Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA, 93105, USA.
+ Bevier, Wendy. Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA, 93105, USA.
+ Conneely, Mary. Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA, 93105, USA.
+ Fan, Ludi. Eli Lilly and Company, Indianapolis, IN, USA.
+ Reed, Beverly. Eli Lilly and Company, Indianapolis, IN, USA.
+ Alatorre, Carlos. Eli Lilly and Company, Indianapolis, IN, USA.
+ Paczkowski, Rosirene. Eli Lilly and Company, Indianapolis, IN, USA.
+ Ahmed, Tamim. Santa Barbara Actuaries, Santa Barbara, CA, USA.
+ Mackenzie, Andrew. Santa Barbara Actuaries, Santa Barbara, CA, USA.
+ Duncan, Ian. Santa Barbara Actuaries, Santa Barbara, CA, USA.
+ Kerr, David. Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA, 93105, USA.
+MeSH Subject Headings
+ Adolescent
+ *Behavioral Risk Factor Surveillance System
+ *Biomarkers/an [Analysis]
+ Child
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/px [Psychology]
+ Family
+ Female
+ Follow-Up Studies
+ *Genetic Predisposition to Disease
+ *Health Status Indicators
+ *Hispanic or Latino/sn [Statistics & Numerical Data]
+ Humans
+ Longitudinal Studies
+ Male
+ Obesity/pp [Physiopathology]
+ Prevalence
+ Prognosis
+ Risk Factors
+ Socioeconomic Factors
+ Surveys and Questionnaires
+ United States/ep [Epidemiology]
+ *White People/sn [Statistics & Numerical Data]
+Keyword Heading
+ Hispanic Americans
+ Latino
+ Social determinants of health
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In the United States (U.S.), the prevalence of both diagnosed and undiagnosed type 2 diabetes (T2D) is nearly twice as high among Mexican-origin Hispanic/Latino adults compared to non-Hispanic Whites. Rates of diabetes-related complications, e.g., acute stroke and end-stage renal disease, are also higher among Hispanic/Latino adults compared to their non-Hispanic/Latino White counterparts. Beyond genetic and biological factors, it is now recognized that sociocultural influences are also important factors in determining risk for T2D and the associated complications. These influences include ethnicity, acculturation, residence, education, and economic status. The primary objective of this study is to determine the influence of the 5 major determinants of human health (genetics, biology, behavior, psychology, society/environment) on the burden of T2D for Latino families. To achieve this objective, Mil Familias (www.milfamilias.sansum.org/) is establishing an observational cohort of 1000 Latino families, with at least one family member living with T2D.
+
+ METHODS: Specially trained, bilingual Latino/a community health workers (Especialistas) recruit participant families and conduct research activities. Each individual family member will contribute data annually on over 100 different variables relating to their genetics, biology, psychology, behavior, and society/environment, creating a Latino-focused biobank ("Living Information Bank"). This observational cohort study is cross-sectional and longitudinal. Participants are divided into 4 groups: adults age >= 18 years with and without T2D, and children age >= 7 and < 18 years with and without T2D. Study activities take place through encounters between families and their Especialista. Encounters include screening/enrollment, informed consent, health promotion assessment, laboratory tests, questionnaires, physical activity monitoring, and reflection.
+
+ DISCUSSION: By creating and providing the framework for the Cohort Establishment study, we intend to inform new approaches regarding equity and excellence in diabetes research and care. We will examine the complex set of factors that contribute to the burden of diabetes in Latino families and assess if cardio-metabolic disease risks go beyond the traditional biological and genetic factors. Breaking the code on the interplay of cardio-metabolic risk factors may help not only this fast growing segment of the U.S. population, but also other high-risk populations.
+
+ TRIAL REGISTRATION: Study retrospectively registered at ClinicalTrials.gov (NCT03830840), 2/5/2019 (enrollment began 2/1/2019).
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1186%2fs12902-019-0483-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Morales&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Understanding+the+impact+of+five+major+determinants+of+health+%28genetics%2C+biology%2C+behavior%2C+psychology%2C+society%2Fenvironment%29+on+type+2+diabetes+in+U.S.+Hispanic%2FLatino+families%3A+Mil+Familias+-+a+cohort+study.&volume=20&issue=1&spage=4&epage=&date=2020&doi=10.1186%2Fs12902-019-0483-z&pmid=31906923&sid=OVID:medline
+
+<1479>
+Unique Identifier
+ 31905026
+Title
+ Addition of trans fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis.
+Source
+ American Journal of Physiology - Gastrointestinal & Liver Physiology. 318(3):G410-G418, 2020 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Daniels SJ; Leeming DJ; Detlefsen S; Bruun MF; Hjuler ST; Henriksen K; Hein P; Krag A; Karsdal MA; Nielsen MJ; Brockbank S; Cruwys S
+Authors Full Name
+ Daniels, Samuel J; Leeming, Diana J; Detlefsen, Sonke; Bruun, Maria F; Hjuler, Sara T; Henriksen, Kim; Hein, Peter; Krag, Aleksander; Karsdal, Morten A; Nielsen, Mette Juul; Brockbank, Sarah; Cruwys, Simon.
+Institution
+ Daniels, Samuel J. Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
+ Daniels, Samuel J. Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
+ Leeming, Diana J. Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
+ Detlefsen, Sonke. Department of Pathology, Odense University Hospital, Odense, Denmark.
+ Bruun, Maria F. Department of Pathology, Odense University Hospital, Odense, Denmark.
+ Hjuler, Sara T. Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
+ Henriksen, Kim. Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
+ Hein, Peter. Innovative Medicines Unit, Grunenthal, Aachen, Germany.
+ Krag, Aleksander. Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
+ Karsdal, Morten A. Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
+ Nielsen, Mette Juul. Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
+ Brockbank, Sarah. Innovative Medicines Unit, Grunenthal, Aachen, Germany.
+ Cruwys, Simon. Innovative Medicines Unit, Grunenthal, Aachen, Germany.
+MeSH Subject Headings
+ Alanine Transaminase/bl [Blood]
+ Animals
+ Aspartate Aminotransferases/bl [Blood]
+ *Binge Drinking/co [Complications]
+ Biomarkers/bl [Blood]
+ *Diet, Atherogenic
+ Disease Models, Animal
+ Dyslipidemias/et [Etiology]
+ Dyslipidemias/me [Metabolism]
+ Dyslipidemias/pa [Pathology]
+ *Fatty Liver, Alcoholic/et [Etiology]
+ Fatty Liver, Alcoholic/me [Metabolism]
+ Fatty Liver, Alcoholic/pa [Pathology]
+ Hepatomegaly/et [Etiology]
+ Hepatomegaly/me [Metabolism]
+ Hepatomegaly/pa [Pathology]
+ Lipid Metabolism
+ Liver/me [Metabolism]
+ *Liver/pa [Pathology]
+ Liver Cirrhosis, Alcoholic/et [Etiology]
+ Liver Cirrhosis, Alcoholic/me [Metabolism]
+ Liver Cirrhosis, Alcoholic/pa [Pathology]
+ Male
+ *Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Oxidative Stress
+ Peptide Fragments/me [Metabolism]
+ Procollagen/me [Metabolism]
+ Rats, Sprague-Dawley
+ *Trans Fatty Acids
+Keyword Heading
+ alcoholic
+ metabolic
+ nonalcoholic
+ rodent models
+ steatohepatitis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are common causes of chronic liver disease. The overlap between ALD and NAFLD suggests the existence of metabolic steatohepatitis. Development of in vivo models that reflect various aspects of human steatohepatitis is essential for drug discovery. We aimed to characterize several models of steatohepatitis (SH) and to investigate whether the pathology could be modulated. Sprague-Dawley rats were fed a high-fat diet (HFD) for 9 wk, followed by either a high-fat, high-cholesterol and cholate diet (HFC) or a HFC diet containing 13% trans fat (HFC-TF). A subset received 15% ethanol-water twice a week for 12 wk. Serum triglycerides, cholesterol, LDL, HDL, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and rodent NH2-terminal propeptide of type III collagen (rPRO-C3) were assessed. The liver was weighed and evaluated using modified Nonalcoholic Steatohepatitis Clinical Research Network histological score system criteria. All diets induced hepatomegaly, but only HFC-TF increased the size of visceral adipose tissue. Trans fat augmented HFC-induced dyslipidemia, and cholesterol was higher and HDL was lower in the HFC-TF groups. Alcohol lowered triglycerides in both dietary groups. HFC elevated ALT and AST, which were lowered by trans fat. All diets induced histological SH, addition of trans fat induced more steatosis but less inflammation. Inclusion of alcohol augmented the HFC-induced inflammation. All diets induced mild fibrosis. Inclusion of trans fat and alcohol significantly increased rPRO-C3. The addition of trans fat reduced the HFC-induced inflammation but augmented steatosis and dyslipidemia. Inclusion of alcohol induced a more inflammatory and fibrogenic phenotype. NEW & NOTEWORTHY Alcoholic liver disease and nonalcoholic liver disease share significant overlap, which suggests the existence of metabolic steatohepatitis. Trans fat has been implicated in steatohepatitis development. Here, we show that the addition of trans fat to an atherogenic diet results in a more steatotic but less inflammatory phenotype, whereas the addition of alcohol to an atherogenic diet augments the inflammatory and fibrogenic properties of the diet.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (Procollagen). 0 (Trans Fatty Acids). 0 (procollagen Type III-N-terminal peptide). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1152%2fajpgi.00066.2019
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Daniels&issn=0193-1857&title=American+Journal+of+Physiology+-+Gastrointestinal+%26+Liver+Physiology&atitle=Addition+of+trans+fat+and+alcohol+has+divergent+effects+on+atherogenic+diet-induced+liver+injury+in+rodent+models+of+steatohepatitis.&volume=318&issue=3&spage=G410&epage=G418&date=2020&doi=10.1152%2Fajpgi.00066.2019&pmid=31905026&sid=OVID:medline
+
+<1480>
+Unique Identifier
+ 31891229
+Title
+ Prospective Study of Long-Term Interrelationships Among Adiposity-Associated Biomarkers in Women.
+Source
+ Obesity. 28(2):452-459, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baden MY; Hu FB; Huang T
+Author NameID
+ Baden, Megu Y; ORCID: https://orcid.org/0000-0002-7678-0969
+Authors Full Name
+ Baden, Megu Y; Hu, Frank B; Huang, Tianyi.
+Institution
+ Baden, Megu Y. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
+ Hu, Frank B. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
+ Hu, Frank B. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
+ Hu, Frank B. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
+ Huang, Tianyi. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
+ Huang, Tianyi. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ *Adiposity/ph [Physiology]
+ Adult
+ *Aging/bl [Blood]
+ Biomarkers/an [Analysis]
+ *Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Insulin/bl [Blood]
+ Interleukin-6/bl [Blood]
+ Leptin/bl [Blood]
+ Longitudinal Studies
+ Middle Aged
+ Obesity/bl [Blood]
+ Prospective Studies
+ Receptors, Leptin/bl [Blood]
+ Sex Factors
+ Time Factors
+Abstract
+ OBJECTIVE: This study aimed to investigate the prospective interrelationships among biomarkers that may provide mechanistic insights into obesity-related diseases.
+
+ METHODS: A total of 850 women in the Nurses' Health Study II with two fasting blood measurements (1996-1999 and 2010-2011) of adiponectin, leptin, soluble leptin receptor, insulin, retinol-binding protein 4, high-sensitivity C-reactive protein (hsCRP), and interleukin-6 were included. Biomarker interrelationships were examined in the following three ways: (1) cross-sectional associations at baseline and follow-up, (2) longitudinal associations of concurrent biomarker changes, and (3) prospective associations of each baseline biomarker with other biomarker changes.
+
+ RESULTS: In cross-sectional analyses, most biomarkers were correlated after multivariable adjustment including BMI, with the strongest correlations observed between leptin and insulin and between hsCRP and interleukin-6. In longitudinal analyses, similar results were observed after multivariable adjustment including weight change. However, in prospective analyses, only three associations observed in cross-sectional and longitudinal analyses were consistently significant (P < 0.05). Every doubling in baseline adiponectin was associated with -9.0% insulin change. The corresponding estimate was 9.3% for baseline leptin and hsCRP change and 3.1% for baseline hsCRP and leptin change.
+
+ CONCLUSIONS: Baseline adiponectin concentrations were inversely associated with subsequent insulin change, whereas baseline leptin concentrations were positively associated with hsCRP change and vice versa. Copyright © 2019 The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Insulin). 0 (Interleukin-6). 0 (LEPR protein, human). 0 (Leptin). 0 (Receptors, Leptin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1002%2foby.22706
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baden&issn=1930-7381&title=Obesity&atitle=Prospective+Study+of+Long-Term+Interrelationships+Among+Adiposity-Associated+Biomarkers+in+Women.&volume=28&issue=2&spage=452&epage=459&date=2020&doi=10.1002%2Foby.22706&pmid=31891229&sid=OVID:medline
+
+<1481>
+Unique Identifier
+ 31878858
+Title
+ A New Perspective on the Relation Between Obesity and Knee Osteoarthritis: Omentin.
+Source
+ Current Rheumatology Reviews. 16(4):324-331, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gundogdu G; Gundogdu K; Miloglu FD; Tasci SY
+Authors Full Name
+ Gundogdu, Gulsah; Gundogdu, Koksal; Miloglu, Fatma Demirkaya; Tasci, Seymanur Yilmaz.
+Institution
+ Gundogdu, Gulsah. Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
+ Gundogdu, Koksal. Department of Orthopedics and Traumatology, Denizli State Hospital, Denizli, Turkey.
+ Miloglu, Fatma Demirkaya. Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey.
+ Tasci, Seymanur Yilmaz. Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Cytokines/bl [Blood]
+ Female
+ GPI-Linked Proteins/bl [Blood]
+ Humans
+ *Lectins/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ *Osteoarthritis, Knee/bl [Blood]
+ Osteoarthritis, Knee/di [Diagnosis]
+ *Osteoarthritis, Knee/ep [Epidemiology]
+Keyword Heading
+ Knee osteoarthritis
+ NO-KOA
+ O-KOA
+ chronic disease
+ degenerative
+ obesity
+ omentin
+ serum
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Knee osteoarthritis (KOA) is defined as a chronic degenerative joint disease. Obesity is a significant risk factor for KOA. Omentin is an adipose tissue-induced adipokine. The aim of the present study was to investigate the correlation between obesity and serum omentin levels in patients with KOA.
+
+ METHODS: This study included 60 patients with KOA, 34 obese individuals (O-KOA) and 26 nonobese individuals (NO-KOA) and 40 controls, 17 obese individuals (OC) and 23 nonobese individuals (NOC) matched in terms of age, sex, and body mass index (BMI) who were recruited from the same polyclinic. Blood samples and knee radiographs were obtained from all the subjects, and clinical features, BMI, and laboratory parameters were recorded. The Kellgren-Lawrence (KL) grade and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index were used to classify the radiographic and clinical findings, respectively. Serum omentin levels were determined using an ELISA.
+
+ RESULTS: Serum omentin levels in patients were significantly lower than those in the controls (p < 0.05). When the BMI values and KL scores were considered, serum omentin levels significantly decreased in severe O-KOA versus in mild-to-moderate O-KOA. There was no statistically significant decrease in severe NO-KOA versus mild-to-moderate NO-KOA. There was a significant negative correlation between the serum omentin level and BMI and WOMAC index. All findings were supported by a receiver operating characteristic curve analysis.
+
+ CONCLUSION: Serum omentin levels were inversely related to obesity and the severity of KOA. The data indicate that omentin may be a new biomarker of KOA to our knowledge and may aid the diagnosis of early-stage O-KOA, if our findings are supported by further studies involving much more samples. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (GPI-Linked Proteins). 0 (ITLN1 protein, human). 0 (Lectins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.2174%2f1573397116666191226122801
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gundogdu&issn=1573-3971&title=Current+Rheumatology+Reviews&atitle=A+New+Perspective+on+the+Relation+Between+Obesity+and+Knee+Osteoarthritis%3A+Omentin.&volume=16&issue=4&spage=324&epage=331&date=2020&doi=10.2174%2F1573397116666191226122801&pmid=31878858&sid=OVID:medline
+
+<1482>
+Unique Identifier
+ 31863321
+Title
+ Metabolite profiling paradoxically reveals favorable levels of lipids, markers of oxidative stress and unsaturated fatty acids in a diabetes susceptible group of Middle Eastern immigrants.
+Source
+ Acta Diabetologica. 57(5):597-603, 2020 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Majdoub M; Spegel P; Bennet L
+Author NameID
+ Bennet, Louise; ORCID: http://orcid.org/0000-0001-7101-1290
+Authors Full Name
+ Al-Majdoub, Mahmoud; Spegel, Peter; Bennet, Louise.
+Institution
+ Al-Majdoub, Mahmoud. Unit of Molecular Metabolism, Department of Clinical Sciences in Malmo, Lund University Diabetes Centre, Lund University, Malmo, Sweden.
+ Spegel, Peter. Centre for Analysis and Synthesis, Department of Chemistry, Lund University Diabetes Centre, Lund University, Lund, Sweden.
+ Bennet, Louise. Department of Clinical Sciences, Family Medicine, Lund University, Skane University Hospital, Building 28, Floor 11, Jan Waldenstroms gata 35, 205 02, Malmo, Sweden. Louise.Bennet@med.lu.se.
+ Bennet, Louise. Center for Primary Health Care Research, Region Skane, Lund University, Malmo, Sweden. Louise.Bennet@med.lu.se.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/eh [Ethnology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Disease Susceptibility
+ Emigrants and Immigrants/sn [Statistics & Numerical Data]
+ *Fatty Acids, Unsaturated/bl [Blood]
+ Female
+ Humans
+ *Hypertension/bl [Blood]
+ Hypertension/ep [Epidemiology]
+ Hypertension/eh [Ethnology]
+ Hypertension/me [Metabolism]
+ Insulin Resistance
+ Iraq/eh [Ethnology]
+ *Lipid Metabolism
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/eh [Ethnology]
+ Obesity/me [Metabolism]
+ *Oxidative Stress
+ Prevalence
+ Sweden/ep [Epidemiology]
+ Sweden/eh [Ethnology]
+Keyword Heading
+ Acylcarnitines
+ Fatty acids
+ Hypertension
+ Ketone bodies
+ Metabolomics
+ Middle East
+ Migration
+ Obesity
+ Type 2 diabetes
+ Uremic solutes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: The population of immigrants from the Middle East in Sweden show a higher prevalence of type 2 diabetes (T2D) compared to native Swedes. The exact reason for this is unknown. Here, we have performed metabolite profiling to investigate these differences.
+
+ METHODS: Metabolite profiling was conducted in Iraqi immigrants (n = 93) and native Swedes (n = 77) using two complementary mass spectrometry-based platforms. Differences in metabolite levels were compared after adjustment for confounding anthropometric, diet and clinical variables.
+
+ RESULTS: The Iraqi immigrant population were more obese (44.1 vs 24.7%, p < 0.05), but had a lower prevalence of hypertension (32.3 vs 54.8%, p < 0.01) than the native Swedish population. We detected 140 metabolites, 26 of which showed different levels between populations (q < 0.05,) after adjustment for age, sex, BMI, T2D and use of metformin. Twenty-two metabolites remained significant after further adjustment for HOMA-IR, HOMA-beta or insulin sensitivity index. Levels of polyunsaturated acylcarnitines (14:2 and 18:2) and fatty acid (18:2) were higher, whereas those of saturated and monounsaturated acylcarnitines (14:0, 18:1, and 8:1), fatty acids (12:0, 14:0, 16:0, and 18:1), uremic solutes (urate and quinate) and ketone bodies (beta-hydroxybutyrate) were lower in Iraqi immigrants. Further, levels of phospholipids were generally lower in the Iraqi immigrant population.
+
+ CONCLUSIONS: Our result suggests an overall beneficial lipid profile in Iraqi immigrants, despite a higher risk to develop T2D. Higher levels of polyunsaturated fatty acids may suggest differences in dietary pattern, which in turn may reduce the risk of hypertension.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Unsaturated).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs00592-019-01464-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Majdoub&issn=0940-5429&title=Acta+Diabetologica&atitle=Metabolite+profiling+paradoxically+reveals+favorable+levels+of+lipids%2C+markers+of+oxidative+stress+and+unsaturated+fatty+acids+in+a+diabetes+susceptible+group+of+Middle+Eastern+immigrants.&volume=57&issue=5&spage=597&epage=603&date=2020&doi=10.1007%2Fs00592-019-01464-w&pmid=31863321&sid=OVID:medline
+
+<1483>
+Unique Identifier
+ 31862687
+Title
+ MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients.
+Source
+ Medical Hypotheses. 136:109524, 2020 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang CY; Zhang CP; Li BJ; Jiang SS; He WH; Long SY; Tian Y
+Authors Full Name
+ Wang, Chu-Yao; Zhang, Cai-Ping; Li, Bo-Jie; Jiang, Su-Su; He, Wei-He; Long, Shi-Yin; Tian, Ying.
+Institution
+ Wang, Chu-Yao. Department of Biochemistry & Molecular Biology, Medical College, University of South China, Hengyang 421001, Hunan, China.
+ Zhang, Cai-Ping. Department of Biochemistry & Molecular Biology, Medical College, University of South China, Hengyang 421001, Hunan, China.
+ Li, Bo-Jie. Department of Biochemistry & Molecular Biology, Medical College, University of South China, Hengyang 421001, Hunan, China.
+ Jiang, Su-Su. Department of Biochemistry & Molecular Biology, Medical College, University of South China, Hengyang 421001, Hunan, China.
+ He, Wei-He. Department of Pharmacology, College of Pharmacy, Hunan University of Chinese Medicine, 300# Xueshi Rd, Hanpu Science & Education District, Changsha 410208, Hunan, China.
+ Long, Shi-Yin. Department of Biochemistry & Molecular Biology, Medical College, University of South China, Hengyang 421001, Hunan, China. Electronic address: shiyinlong@usc.edu.cn.
+ Tian, Ying. Affiliated Nanhua Hospital, University of South China, 336# S Dongfeng Rd., Hengyang 421001, Hunan, China. Electronic address: uscty@usc.edu.cn.
+MeSH Subject Headings
+ Animals
+ Apoptosis
+ Biomarkers/me [Metabolism]
+ Brain Ischemia/co [Complications]
+ *Brain Ischemia/di [Diagnosis]
+ Humans
+ Incidence
+ Inflammation
+ Ischemic Stroke/co [Complications]
+ *Ischemic Stroke/di [Diagnosis]
+ Longevity
+ *Matrix Metalloproteinase 12/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity/pp [Physiopathology]
+ Thrombin/me [Metabolism]
+Keyword Heading
+ Body mass index
+ Ischemic stroke
+ Matrix metalloproteinase-12
+ Obesity
+ Obesity paradox
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Human health is threatened by obesity which causes the increasing incidence of various diseases, especially stroke. Ischemic stroke (IS) is mostly caused by the rupture of arterial plaque, whose instability is positively associated with matrix metalloproteinases (MMPs) that degrades extracellular matrix components. Studies have shown that matrix metalloproteinase-12 (MMP-12) may be involved in the pathogenesis of IS. Because of the higher incidence of stroke in obese patients than that in normal weight people, it is urgent for obesity to forecast stroke early. Considering high levels MMP-12 in obesity, we put forward that MMP-12 may be a potential biomarker for IS in obese patients. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4-21-5 (Thrombin). EC 3-4-24-65 (MMP12 protein, human). EC 3-4-24-65 (Matrix Metalloproteinase 12).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.mehy.2019.109524
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0306-9877&title=Medical+Hypotheses&atitle=MMP-12+as+a+potential+biomarker+to+forecast+ischemic+stroke+in+obese+patients.&volume=136&issue=&spage=109524&epage=&date=2020&doi=10.1016%2Fj.mehy.2019.109524&pmid=31862687&sid=OVID:medline
+
+<1484>
+Unique Identifier
+ 31841602
+Title
+ The Melanocortin 4 Receptor p.Ile269Asn Mutation Is Associated with Childhood and Adult Obesity in Mexicans.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(4), 2020 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vazquez-Moreno M; Zeng H; Locia-Morales D; Peralta-Romero J; Asif H; Maharaj A; Tam V; Romero-Figueroa MDS; Sosa-Bustamante GP; Mendez-Martinez S; Mejia-Benitez A; Valladares-Salgado A; Wacher-Rodarte N; Cruz M; Meyre D
+Corporate Author
+ National Obesity Network Mexico
+Authors Full Name
+ Vazquez-Moreno, Miguel; Zeng, Helen; Locia-Morales, Daniel; Peralta-Romero, Jesus; Asif, Hamza; Maharaj, Arjuna; Tam, Vivian; Romero-Figueroa, Maria D S; Sosa-Bustamante, Gloria P; Mendez-Martinez, Socorro; Mejia-Benitez, Aurora; Valladares-Salgado, Adan; Wacher-Rodarte, Niels; Cruz, Miguel; Meyre, David.
+Institution
+ Vazquez-Moreno, Miguel. Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
+ Vazquez-Moreno, Miguel. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
+ Zeng, Helen. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
+ Locia-Morales, Daniel. Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
+ Peralta-Romero, Jesus. Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
+ Asif, Hamza. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
+ Maharaj, Arjuna. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
+ Tam, Vivian. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
+ Romero-Figueroa, Maria D S. Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anahuac, Campus Norte, Huixquilucan, Mexico.
+ Sosa-Bustamante, Gloria P. Hospital de Gineco-Pediatria, Instituto Mexicano del Seguro Social Leon, Guanajuato, Mexico.
+ Mendez-Martinez, Socorro. Coordinacion de Investigacion en Salud, Instituto Mexicano del Seguro Social Puebla, Puebla, Mexico.
+ Mejia-Benitez, Aurora. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
+ Valladares-Salgado, Adan. Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
+ Wacher-Rodarte, Niels. Unidad de Investigacion en Epidemiologia Clinica, Hospital de Especialidades Bernardo Sepulveda, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
+ Cruz, Miguel. Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
+ Meyre, David. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
+ Meyre, David. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ Child
+ Female
+ Follow-Up Studies
+ *Genetic Predisposition to Disease
+ Genotype
+ Humans
+ Male
+ Mexico/ep [Epidemiology]
+ Middle Aged
+ *Mutation
+ *Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ Pedigree
+ Phenotype
+ Prognosis
+ *Receptor, Melanocortin, Type 4/ge [Genetics]
+Keyword Heading
+ Mexican population
+ adults
+ children
+ melanocortin
+ mutation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Rare partial/complete loss-of-function mutations in the melanocortin-4 receptor (MC4R) gene are the most common cause of Mendelian obesity in European populations, but their contribution to obesity in the Mexican population is unclear.
+
+ OBJECTIVE AND DESIGN: We investigated whether deleterious mutations in MC4R contribute to obesity in Mexican children and adults.
+
+ RESULTS: We provide evidence that the MC4R p.Ile269Asn (rs79783591) mutation may have arisen in modern human populations from a founder event in native Mexicans. The MC4R Isoleucine 269 is perfectly conserved across 184 species, which suggests a critical role for the amino acid in MC4R activity. Four in silico tools (SIFT, PolyPhen-2, CADD, MutPred2) predicted a deleterious impact of the p.Ile269Asn substitution on MC4R function. The MC4R p.Ile269Asn mutation was associated with childhood (Ncontrols = 952, Ncases = 661, odds ratio (OR) = 3.06, 95% confidence interval (95%CI) [1.94-4.85]) and adult obesity (Ncontrols = 1445, Ncases = 2,487, OR = 2.58, 95%CI [1.52-4.39]). The frequency of the MC4R p.Ile269Asn mutation ranged from 0.52 to 0.59% and 1.53 to 1.59% in children and adults with normal weight and obesity, respectively. The MC4R p.Ile269Asn mutation co-segregated perfectly with obesity in 5 multigenerational Mexican pedigrees. While adults with obesity carrying the p.Ile269Asn mutation had higher BMI values than noncarriers, this trend was not observed in children. The MC4R p.Ile269Asn mutation accounted for a population attributable risk of 1.28% and 0.68% for childhood and adult obesity, respectively, in the Mexican population.
+
+ CONCLUSION: The MC4R p.Ile269Asn mutation may have emerged as a founder mutation in native Mexicans and is associated with childhood and adult obesity in the modern Mexican population. Copyright © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MC4R protein, human). 0 (Receptor, Melanocortin, Type 4).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1210%2fclinem%2fdgz276
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vazquez-Moreno&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=The+Melanocortin+4+Receptor+p.Ile269Asn+Mutation+Is+Associated+with+Childhood+and+Adult+Obesity+in+Mexicans.&volume=105&issue=4&spage=e1468&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgz276&pmid=31841602&sid=OVID:medline
+
+<1485>
+Unique Identifier
+ 31830529
+Title
+ Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges.
+Source
+ Bone. 132:115124, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Geserick M; Vogel M; Eckelt F; Schlingmann M; Hiemisch A; Baber R; Thiery J; Korner A; Kiess W; Kratzsch J
+Authors Full Name
+ Geserick, M; Vogel, M; Eckelt, F; Schlingmann, M; Hiemisch, A; Baber, R; Thiery, J; Korner, A; Kiess, W; Kratzsch, J.
+Institution
+ Geserick, M. LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany.
+ Vogel, M. LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany.
+ Eckelt, F. Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM) Leipzig University, Paul-List-Strasse 13-15, 04103 Leipzig, Germany.
+ Schlingmann, M. LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany; Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Liebigstrasse 20a, 04103 Leipzig, Germany.
+ Hiemisch, A. LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany; Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Liebigstrasse 20a, 04103 Leipzig, Germany.
+ Baber, R. LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany; Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM) Leipzig University, Paul-List-Strasse 13-15, 04103 Leipzig, Germany.
+ Thiery, J. LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany; Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM) Leipzig University, Paul-List-Strasse 13-15, 04103 Leipzig, Germany.
+ Korner, A. LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany; Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Liebigstrasse 20a, 04103 Leipzig, Germany; Integrated Research and Treatment Center (IFB) AdiposityDiseases, University of Leipzig, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany.
+ Kiess, W. LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany; Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Liebigstrasse 20a, 04103 Leipzig, Germany.
+ Kratzsch, J. Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM) Leipzig University, Paul-List-Strasse 13-15, 04103 Leipzig, Germany. Electronic address: juergen.kratzsch@medizin.uni-leipzig.de.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers
+ *Bone Remodeling
+ Child
+ Collagen Type I
+ Female
+ Humans
+ Infant
+ Male
+ Obesity
+ *Parathyroid Hormone
+ Peptide Fragments
+ Procollagen
+ Reference Values
+ Vitamin D/aa [Analogs & Derivatives]
+Keyword Heading
+ 25-Hydroxy-vitamin d
+ Adolescents
+ BMI
+ Bone marker
+ CTX-I
+ Children
+ Osteocalcin
+ P1NP
+ PTH
+ Reference range
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: We aimed to establish age- and gender-specific reference ranges for concentrations of the bone markers osteocalcin (OC), procollagen type 1 N-propeptides (PINP) and carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX-I) as well as for the calciotropic hormones 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) in healthy infants, children and adolescents. In addition, the effect of age, gender, puberty and body mass index (BMI) on bone markers was investigated.
+
+ METHODS: 2416 healthy subjects (5714 blood withdrawals), aged 3 months to 17 years, were included to estimate the age- and gender-dependence of reference ranges. Subsequently, measured values of the biomarkers were transformed to standard deviation scores (SDS) and their associations with age, gender and puberty were analyzed. Bone marker-SDS values of the reference cohort were compared with an obese cohort (n = 317 and 489 blood withdrawals) to analyze the effect of BMI.
+
+ RESULTS: OC, PINP and CTX-I showed a distinct age- and gender-dependence with peak levels at 10 to 11 years (girls, Tanner 3) and 13 years (boys, Tanner 3-4). Children with obesity had significantly lower SDS levels for OC (-0.44), PINP (-0.27), CTX-I (-0.33), 25(OH)D (-0.43) and higher SDS levels for PTH (+0.44) than the reference cohort.
+
+ CONCLUSIONS: OC, PINP and CTX-I vary with age, gender and pubertal stage. The body weight status has to be considered in the interpretation of pediatric OC, PINP, CTX-I, 25(OH)D and PTH levels. Consequences of childhood obesity on bone health should be carefully investigated in long-term studies. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Collagen Type I). 0 (Parathyroid Hormone). 0 (Peptide Fragments). 0 (Procollagen). 1406-16-2 (Vitamin D). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.bone.2019.115124
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Geserick&issn=1873-2763&title=Bone&atitle=Children+and+adolescents+with+obesity+have+reduced+serum+bone+turnover+markers+and+25-hydroxyvitamin+D+but+increased+parathyroid+hormone+concentrations+-+Results+derived+from+new+pediatric+reference+ranges.&volume=132&issue=&spage=115124&epage=&date=2020&doi=10.1016%2Fj.bone.2019.115124&pmid=31830529&sid=OVID:medline
+
+<1486>
+Unique Identifier
+ 31812909
+Title
+ Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity.
+Source
+ Journal of Nutritional Biochemistry. 76:108303, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Costa MC; Lima TFO; Arcaro CA; Inacio MD; Batista-Duharte A; Carlos IZ; Spolidorio LC; Assis RP; Brunetti IL; Baviera AM
+Authors Full Name
+ Costa, Mariana Campos; Lima, Tayra Ferreira Oliveira; Arcaro, Carlos Alberto; Inacio, Maiara Destro; Batista-Duharte, Alexander; Carlos, Iracilda Zeppone; Spolidorio, Luis Carlos; Assis, Renata Pires; Brunetti, Iguatemy Lourenco; Baviera, Amanda Martins.
+Institution
+ Costa, Mariana Campos. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Lima, Tayra Ferreira Oliveira. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Arcaro, Carlos Alberto. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Inacio, Maiara Destro. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Batista-Duharte, Alexander. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Carlos, Iracilda Zeppone. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Spolidorio, Luis Carlos. Sao Paulo State University (Unesp), Araraquara School of Dentistry, Department of Physiology and Pathology, Araraquara, Sao Paulo, Brazil.
+ Assis, Renata Pires. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil; Paulista University (UNIP), Institute of Health Sciences, Araraquara, Sao Paulo, Brazil.
+ Brunetti, Iguatemy Lourenco. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil.
+ Baviera, Amanda Martins. Sao Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, Sao Paulo, Brazil. Electronic address: amanda.baviera@unesp.br.
+MeSH Subject Headings
+ *Alkaloids/ad [Administration & Dosage]
+ Animals
+ Antioxidants/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ Body Weight
+ *Curcumin/ad [Administration & Dosage]
+ Diet, High-Fat
+ Disease Models, Animal
+ Drug Therapy, Combination
+ Glucose/me [Metabolism]
+ Glucose Tolerance Test
+ *Glycosylation/de [Drug Effects]
+ Homeostasis
+ *Inflammation/dt [Drug Therapy]
+ Kidney/de [Drug Effects]
+ Kidney/me [Metabolism]
+ Lipid Peroxidation/de [Drug Effects]
+ Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ *Obesity/dt [Drug Therapy]
+ *Oxidative Stress/de [Drug Effects]
+Keyword Heading
+ Advanced glycation
+ Curcumin
+ Inflammation
+ Obesity
+ Oxidative stress
+ Trigonelline
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The development of obesity-associated complications is related to various pathogenic events including chronic inflammation, oxidative stress and generation of advanced glycation end products (AGEs). Due to their antioxidant, anti-inflammatory and antiglycation properties, trigonelline and curcumin are interesting candidates to counteract complications of obesity and diabetes mellitus. The current study aimed to investigate the effects of treatment with curcumin or trigonelline mixed into yoghurt, alone or in combination, on mice fed high-fat diet (HFD); the focus was mainly on the potential of these phytochemicals to counteract oxidative and glycative stress. Yoghurt alone improved glucose tolerance and reduced proinflammatory cytokine levels in HFD mice; however, it did not affect the antioxidant status. Trigonelline-enriched yoghurt prevented fat accumulation in adipose tissue, improved both insulin sensitivity and glucose tolerance and exerted anti-inflammatory and antiglycation activities (reduced AGEs and AGE receptor levels and increased the levels of components related to AGE detoxification) in liver and kidney of HFD mice. Curcumin-enriched yoghurt exerted anti-inflammatory and potent antioxidant properties (increased antioxidant enzyme activities and decreased lipid peroxidation) in liver and kidney of HFD mice. However, several beneficial effects were nullified when trigonelline and curcumin were administered in combination. Trigonelline and curcumin have emerged as promising complementary therapy candidates for liver and kidney complications associated with obesity. However, the administration of these phytochemicals in combination, at least in HFD mice, was not effective; inhibition of biotransformation processes and/or the reaching of toxic doses during combined treatment may be prevailing over the individual pharmacodynamic actions of these phytochemicals. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Alkaloids). 0 (Antioxidants). 0 (Biomarkers). 0 (Blood Glucose). 3NQ9N60I00 (trigonelline). IT942ZTH98 (Curcumin). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.jnutbio.2019.108303
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Costa&issn=0955-2863&title=Journal+of+Nutritional+Biochemistry&atitle=Trigonelline+and+curcumin+alone%2C+but+not+in+combination%2C+counteract+oxidative+stress+and+inflammation+and+increase+glycation+product+detoxification+in+the+liver+and+kidney+of+mice+with+high-fat+diet-induced+obesity.&volume=76&issue=&spage=108303&epage=&date=2020&doi=10.1016%2Fj.jnutbio.2019.108303&pmid=31812909&sid=OVID:medline
+
+<1487>
+Unique Identifier
+ 31811995
+Title
+ Adipose tissue dysfunction and metabolic disorders: Is it possible to predict who will develop type 2 diabetes mellitus? Role of markErs in the progreSsion of dIabeteS in obese paTIeNts (The RESISTIN trial).
+Source
+ Cytokine. 127:154947, 2020 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Derosa G; Catena G; Gaudio G; D'Angelo A; Maffioli P
+Authors Full Name
+ Derosa, Giuseppe; Catena, Gabriele; Gaudio, Giovanni; D'Angelo, Angela; Maffioli, Pamela.
+Institution
+ Derosa, Giuseppe. Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Centre for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy. Electronic address: giuseppe.derosa@unipv.it.
+ Catena, Gabriele. Cardiologic Unit, ASL of Teramo, Teramo, Italy.
+ Gaudio, Giovanni. Internal Medicine Division, Ospedale Angelo Bellini, Somma Lombardo, Varese, Italy.
+ D'Angelo, Angela. Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy.
+ Maffioli, Pamela. Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
+MeSH Subject Headings
+ Adiponectin/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pa [Pathology]
+ *Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ *Metabolic Diseases/co [Complications]
+ Metabolic Diseases/me [Metabolism]
+ Metabolic Diseases/pa [Pathology]
+ Middle Aged
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ *Resistin/me [Metabolism]
+ Retrospective Studies
+Keyword Heading
+ Adipokines
+ Insulin resistance
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The aim of this study was to valuate if there are some differences in metabolic parameters among obese which will develop diabetes and those that will not develop diabetes. We enrolled 959 obese, normal glucose tolerant, of either sex, outpatients and evaluated them for 8 years. We evaluated: body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment (HOMA) index, blood pressure, lipid profile, lipoprotein(a), adiponectin (ADN), resistin, leptin, high sensitivity reactive protein (Hs-CRP), tumor necrosis factor-alpha (TNF-alpha), retinol binding protein-4 (RBP-4), adipsin, vaspin, visfatin, omentin-1, chemerin. After 8 years of observation, 429 patients maintained euglycemia, while 133 patients developed dysglycemia, and 90 developed diabetes. In dysglycemic patients, ADN was lower, and resistin was higher compared to baseline, while in diabetic patients ADN was lower, and resistin was higher both compared to baseline, and compared to euglycemic and dysglycemic patients. High sensitivity C-reactive protein, TNF-alpha were higher in both dysglycemic and diabetic patients compared to baseline, but the values recorded in diabetics were higher both compared to euglycemic and dysglycemic. Visfatin was higher and omentin-1 was lower compared to baseline, and compared to euglycemic patients in diabetics. Odds ratio showed that lower levels of adiponectin and higher levels of resistin, but not of other cytokines, increased the risk of developing type 2 diabetes mellitus. Data seem to suggest that lower levels of adiponectin, and higher levels of resistin can be predictive of a future diabetes in obese people, even years before the disease onset. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Resistin).
+Publication Type
+ Clinical Trial. Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.cyto.2019.154947
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Derosa&issn=1043-4666&title=Cytokine&atitle=Adipose+tissue+dysfunction+and+metabolic+disorders%3A+Is+it+possible+to+predict+who+will+develop+type+2+diabetes+mellitus%3F+Role+of+markErs+in+the+progreSsion+of+dIabeteS+in+obese+paTIeNts+%28The+RESISTIN+trial%29.&volume=127&issue=&spage=154947&epage=&date=2020&doi=10.1016%2Fj.cyto.2019.154947&pmid=31811995&sid=OVID:medline
+
+<1488>
+Unique Identifier
+ 31811884
+Title
+ Low serum amylase, lipase, and trypsin as biomarkers of metabolic disorders: A systematic review and meta-analysis.
+Source
+ Diabetes Research & Clinical Practice. 159:107974, 2020 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ko J; Cho J; Petrov MS
+Authors Full Name
+ Ko, Juyeon; Cho, Jaelim; Petrov, Maxim S.
+Institution
+ Ko, Juyeon. School of Medicine, University of Auckland, Auckland, New Zealand.
+ Cho, Jaelim. School of Medicine, University of Auckland, Auckland, New Zealand.
+ Petrov, Maxim S. School of Medicine, University of Auckland, Auckland, New Zealand. Electronic address: max.petrov@gmail.com.
+MeSH Subject Headings
+ *Amylases/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 1/bl [Blood]
+ Diabetes Mellitus, Type 1/di [Diagnosis]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Humans
+ *Lipase/bl [Blood]
+ Metabolic Diseases/bl [Blood]
+ *Metabolic Diseases/di [Diagnosis]
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Overweight/bl [Blood]
+ Overweight/di [Diagnosis]
+ *Trypsin/bl [Blood]
+Abstract
+ AIMS: While there is plentiful evidence on elevated serum levels of amylase, lipase, and trypsin in acute illness, low serum levels of these digestive enzymes have been studied infrequently. The aim was to systematically review published studies on the relationship between low serum levels of amylase, lipase, or trypsin and metabolic disorders.
+
+ METHODS: The search was conducted in MEDLINE and Scopus databases. Studies in humans were included if they reported on the association between serum levels of amylase, lipase, or trypsin within normal range and metabolic disorders. Random-effects meta-analysis was conducted.
+
+ RESULTS: A total of 20 studies encompassing 20,916 participants were included. Compared with healthy individuals, individuals with type 2 diabetes mellitus (mean difference = -5.3; p < 0.001), metabolic syndrome (mean difference = -5.1; p < 0.001), and overweight/obesity (mean difference = -0.8; p = 0.02) had significantly lower serum levels of amylase. Both individuals with type 1 diabetes mellitus (mean difference = -1.8; p < 0.001) and type 2 diabetes mellitus (mean difference = -0.8; p < 0.001) had significantly lower serum levels of lipase compared with healthy individuals. Data on serum trypsin were not suitable for meta-analysis. In the pooled analysis, individuals with type 2 diabetes mellitus had 3.1-times lower serum levels of amylase, 2.9-times lower serum levels of lipase, and 2.5-times lower serum levels of trypsin levels than the upper limits of normal for the three digestive enzymes.
+
+ CONCLUSION: Low serum levels of amylase and lipase are significantly associated with type 2 diabetes mellitus, type 1 diabetes mellitus, excess adiposity, and metabolic syndrome. The role of digestive enzymes in the pathogenesis of metabolic disorders warrants further investigations. Copyright © 2019 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-1-1-3 (Lipase). EC 3-2-1 (Amylases). EC 3-4-21-4 (Trypsin).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.diabres.2019.107974
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ko&issn=0168-8227&title=Diabetes+Research+%26+Clinical+Practice&atitle=Low+serum+amylase%2C+lipase%2C+and+trypsin+as+biomarkers+of+metabolic+disorders%3A+A+systematic+review+and+meta-analysis.&volume=159&issue=&spage=107974&epage=&date=2020&doi=10.1016%2Fj.diabres.2019.107974&pmid=31811884&sid=OVID:medline
+
+<1489>
+Unique Identifier
+ 31810825
+Title
+ Regulation of hepcidin/iron-signalling pathway interactions by commensal bifidobateria plays an important role for the inhibition of metaflammation-related biomarkers.
+Source
+ Immunobiology. 225(1):151874, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ghadimi D; Yoness Hassan MF; Folster-Holst R; Rocken C; Ebsen M; de Vrese M; Heller KJ
+Authors Full Name
+ Ghadimi, Darab; Yoness Hassan, Mohamed Farghaly; Folster-Holst, Regina; Rocken, Christoph; Ebsen, Michael; de Vrese, Michael; Heller, Knut J.
+Institution
+ Ghadimi, Darab. Department of Microbiology and Biotechnology, Max Rubner-Institut, Hermann-Weigmann-Str 1, D-24103, Kiel, Germany. Electronic address: darab.ghadimi@mri.bund.de.
+ Yoness Hassan, Mohamed Farghaly. Department of Microbiology and Biotechnology, Max Rubner-Institut, Hermann-Weigmann-Str 1, D-24103, Kiel, Germany.
+ Folster-Holst, Regina. Clinic of Dermatology, University Hospital Schleswig-Holstein, Schittenhelmstr. 7, D-24105 Kiel, Germany.
+ Rocken, Christoph. Institute of Pathology, Kiel University, University Hospital, Schleswig-Holstein, Arnold-Heller-Strase 3/14, D-24105, Kiel, Germany.
+ Ebsen, Michael. Stadtisches MVZ Kiel GmbH (Kiel City Hospital), Department of Pathology, Chemnitzstr.33, 24116, Kiel, Germany.
+ de Vrese, Michael. Department of Microbiology and Biotechnology, Max Rubner-Institut, Hermann-Weigmann-Str 1, D-24103, Kiel, Germany.
+ Heller, Knut J. Department of Microbiology and Biotechnology, Max Rubner-Institut, Hermann-Weigmann-Str 1, D-24103, Kiel, Germany.
+MeSH Subject Headings
+ *Bifidobacterium/ph [Physiology]
+ Biomarkers/me [Metabolism]
+ Coculture Techniques
+ Diet, High-Fat
+ HT29 Cells
+ Hep G2 Cells
+ *Hepcidins/me [Metabolism]
+ Humans
+ *Inflammation/me [Metabolism]
+ *Intestinal Mucosa/im [Immunology]
+ Intestinal Mucosa/mi [Microbiology]
+ *Iron/me [Metabolism]
+ Lipopolysaccharides/me [Metabolism]
+ NF-kappa B/me [Metabolism]
+ *Obesity/im [Immunology]
+ Oleic Acid/me [Metabolism]
+ Signal Transduction
+ Symbiosis
+ Toll-Like Receptor 4/me [Metabolism]
+Keyword Heading
+ Bifidobacteria
+ Hepcidin
+ IL-6
+ Iron
+ Metaflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Increased concentration of ferrous iron in the gastrointestinal tract increases the number of various pathogens and induces inflammation. LPS and/or high-fat diet-associated metaflammation is mediated through a quaternary receptor signaling complex containing iron-regulated pathway, IL-6/STAT inflammatory signaling pathway, hepcidin regulatory pathway, and common TLR4/NF-kappaB signaling pathway. We, therefore, investigated whether bifidobacteria directly or indirectly ameliorate LPS- and/or high-fat diet-associated metaflammation by reduction of intestinal iron concentration and/or the above-mentioned pathways.
+
+ MATERIAL & METHODS: We used a triple co-culture model of HT-29/B6, HMDM and HepG2 cells with apically added Bifidobacterium pseudolongum (DSMZ 20099), in the absence or presence of iron, LPS or oleate. Expressions of the biomarkers of interest were determined after 24 h incubation by TaqMan qRT-PCR, cell-based ELISA or Western blot.
+
+ RESULTS: Bifidobacteria inhibited LPS- and oleate-induced protein expression of inflammatory cytokines (IL-6, TNF-alpha) concomitantly with decreases in cellular TG and iron concentration. Exposure of co-cultured cells to bifidobacteria blocked NF-kB activity through inhibition of IkappaBalpha, p38 MAPK, and phosphorylation of NF-kB 65 subunit. TaqMan qRT-PCR and Western blot analysis revealed that bifidobacteria downregulated mRNA and protein expression of BMP6, DMT1, hepcidin, l-ferritin, ferroportin, IL-6, TfR1, Stat3, and TLR4 following exposure to excessive extracellular LPS, oleate and iron. However, the patterns of TLR2 mRNA and protein expression were quite the opposite of those of TLR4.
+
+ CONCLUSION: Commensal bifidobacteria ameliorate metaflammation/inflammatory responses to excessive extracellular LPS, oleate and iron through at least two molecular/signaling mechanisms: i. modulation of interactions of the hepcidin- and iron-signaling pathways via reduction of excess iron; ii. reduction of pro-inflammatory cytokines and hepcidin production through inhibition of the TLR4/NF-kB pathway. This may be a molecular basis by which commensal bifidobacteria enhance intrinsic cellular tolerance against excess consumption of energy-yielding substrates and/or free iron. Copyright © 2019 Elsevier GmbH. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hepcidins). 0 (Lipopolysaccharides). 0 (NF-kappa B). 0 (TLR4 protein, human). 0 (Toll-Like Receptor 4). 2UMI9U37CP (Oleic Acid). E1UOL152H7 (Iron).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.imbio.2019.11.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ghadimi&issn=0171-2985&title=Immunobiology&atitle=Regulation+of+hepcidin%2Firon-signalling+pathway+interactions+by+commensal+bifidobateria+plays+an+important+role+for+the+inhibition+of+metaflammation-related+biomarkers.&volume=225&issue=1&spage=151874&epage=&date=2020&doi=10.1016%2Fj.imbio.2019.11.009&pmid=31810825&sid=OVID:medline
+
+<1490>
+Unique Identifier
+ 31809363
+Title
+ Intestinal Dysbiosis and Markers of Systemic Inflammation in Viscerally and Generally Obese Persons Living With HIV.
+Source
+ Journal of Acquired Immune Deficiency Syndromes: JAIDS. 83(1):81-89, 2020 01 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gogokhia L; Taur Y; Juluru K; Yagan N; Zhu YS; Pamer E; Glesby MJ
+Authors Full Name
+ Gogokhia, Lasha; Taur, Ying; Juluru, Krishna; Yagan, Neda; Zhu, Yuan-Shan; Pamer, Eric; Glesby, Marshall J.
+Institution
+ Gogokhia, Lasha. Division of Gastroenterology and Hepatology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Jill Roberts Center and Institute for Research in Inflammatory Bowel Disease, New York, NY.
+ Gogokhia, Lasha. Currently, Johnston Memorial Hospital, Abingdon, VA.
+ Taur, Ying. Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, NY.
+ Juluru, Krishna. Department of Radiology, Weill Cornell Medicine, New York, NY.
+ Juluru, Krishna. Currently, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
+ Yagan, Neda. Department of Radiology, Weill Cornell Medicine, New York, NY.
+ Yagan, Neda. Currently, Advanced Radiology Consultants, Shelton, CT.
+ Zhu, Yuan-Shan. Clinical and Translational Science Center and Weill Department of Medicine, Weill Cornell Medicine, New York, NY.
+ Pamer, Eric. Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, NY.
+ Pamer, Eric. Currently, Department of Medicine, Section of Infectious Diseases and Global Health, The Duchossois Family Institute, The University of Chicago, Chicago, IL; and.
+ Glesby, Marshall J. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/me [Metabolism]
+ Cross-Sectional Studies
+ *Dysbiosis/pp [Physiopathology]
+ Female
+ *HIV Infections/me [Metabolism]
+ Humans
+ *Inflammation/me [Metabolism]
+ *Intra-Abdominal Fat/me [Metabolism]
+ Male
+ *Obesity/me [Metabolism]
+Abstract
+ BACKGROUND: The intestinal microbiota contributes to the pathogenesis of obesity and metabolic disorders. People living with HIV (PLWH) have a higher risk for the development of visceral adiposity with accompanying worsened cardiovascular risk.
+
+ SETTING: Convenience sample from an HIV clinic and research unit.
+
+ METHODS: To understand the relationship between adiposity and intestinal dysbiosis, we compared the gut microbiota and inflammatory markers in a cross-sectional study of viscerally obese, generally obese, and lean PLWH. Fecal intestinal microbiota was characterized by 16S ribosomal DNA sequencing. Abdominal CTs quantified subcutaneous adipose tissue and visceral adipose tissue (SAT; VAT). Serum high sensitivity C-reactive protein, adiponectin, leptin, IL-6, MCP-1, and sCD14 were assayed.
+
+ RESULTS: We studied 15, 9, and 11 participants with visceral obesity, general obesity, and lean body type, respectively. The generally obese group were all women and 2/3 African American, whereas the visceral obesity and lean groups were predominantly white and men who have sex with men. Markers of systemic inflammation and sCD14 were higher in general obesity compared with lean. sCD14 was positively correlated with VAT, but not SAT. Bacterial diversity was significantly reduced in participants with visceral and general obesity and composition of intestinal microbiota was significantly different from lean body types. Bacterial alpha diversity was negatively correlated with VAT area, waist/hip ratio, and sCD14, but not with SAT area.
+
+ CONCLUSIONS: In this exploratory study, obesity in general was associated with dysbiotic intestinal microbiota. The relationships of VAT to bacterial diversity and sCD14 suggest that dysbiosis in viscerally obese PLWH could be associated with heightened inflammatory state.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1097%2fQAI.0000000000002229
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gogokhia&issn=1525-4135&title=Journal+of+Acquired+Immune+Deficiency+Syndromes%3A+JAIDS&atitle=Intestinal+Dysbiosis+and+Markers+of+Systemic+Inflammation+in+Viscerally+and+Generally+Obese+Persons+Living+With+HIV.&volume=83&issue=1&spage=81&epage=89&date=2020&doi=10.1097%2FQAI.0000000000002229&pmid=31809363&sid=OVID:medline
+
+<1491>
+Unique Identifier
+ 31805224
+Title
+ Obesity, sedentary lifestyle, and exhaled nitric oxide in an early adolescent cohort.
+Source
+ Pediatric Pulmonology. 55(2):503-509, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Flashner BM; Rifas-Shiman SL; Oken E; Camargo CA; Platts-Mills TJ; Workman L; Litonjua AA; Gold DR; Rice MB
+Author NameID
+ Flashner, Bess M; ORCID: https://orcid.org/0000-0002-6186-5732
+Authors Full Name
+ Flashner, Bess M; Rifas-Shiman, Sheryl L; Oken, Emily; Camargo, Carlos A; Platts-Mills, Thomas J; Workman, Lisa; Litonjua, Augusto A; Gold, Diane R; Rice, Mary B.
+Institution
+ Flashner, Bess M. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
+ Rifas-Shiman, Sheryl L. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
+ Oken, Emily. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
+ Camargo, Carlos A. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
+ Camargo, Carlos A. Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts.
+ Platts-Mills, Thomas J. Department of Allergy and Immunology, University of Virginia Health System, Charlottesville, Virginia.
+ Workman, Lisa. Department of Allergy and Immunology, University of Virginia Health System, Charlottesville, Virginia.
+ Litonjua, Augusto A. Pediatric Pulmonary Division, Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, New York.
+ Gold, Diane R. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
+ Gold, Diane R. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
+ Rice, Mary B. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
+MeSH Subject Headings
+ Adipose Tissue
+ Adolescent
+ Asthma/pp [Physiopathology]
+ Biomarkers
+ Body Mass Index
+ Child
+ Cohort Studies
+ Exhalation
+ Female
+ Humans
+ Hypersensitivity/co [Complications]
+ Inflammation/co [Complications]
+ Male
+ Nitric Oxide/an [Analysis]
+ *Nitric Oxide/me [Metabolism]
+ *Obesity
+ Overweight/co [Complications]
+ *Sedentary Behavior
+ Thinness/co [Complications]
+ Waist Circumference
+Keyword Heading
+ asthma
+ inflammation
+ overweight
+ teenagers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Fractional exhaled nitric oxide (FeNO) is a marker of airway inflammation that is well-characterized in allergic disease states. However, FeNO is also involved in nonallergic inflammatory and pulmonary vascular mechanisms or responses to environmental stimuli. We sought to determine the extent to which obesity or sedentary lifestyle is associated with FeNO in adolescents not selected on the basis of allergic disease. In Project Viva, a prebirth cohort study, we measured body mass index (BMI), skinfold thicknesses, waist circumference, body fat, hours watching television, hours of physical activity, and heart rate after exercise among 929 adolescents (median age, 12.9). We measured FeNO twice and averaged these as a continuous, log-transformed outcome. We performed linear regression models, adjusted for child age, sex, height, and race/ethnicity, maternal education and smoking during pregnancy, household income and smoking, and neighbourhood characteristics. In secondary analysis, we additionally adjusted for asthma. More than 2 hours spent watching TV was associated with 10% lower FeNO (95% confidence interval [CI]: -20, 0%). Higher body fat percentage was also associated with lower FeNO. After additional adjustment for asthma, teens who are underweight (BMI <5th %tile, 3%) had 22% lower FeNO (95%CI: -40, 2%) and teens who are overweight (BMI >=85th %ile, 28%) had 13% lower FeNO (95%CI: -23, -2%). Each of these associations of lifestyle and body weight with lower FeNO were greater in magnitude after adjusting for asthma. In summary, sedentary lifestyle, high and low BMI were all associated with lower FeNO in this adolescent cohort. Copyright © 2019 Wiley Periodicals, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 31C4KY9ESH (Nitric Oxide).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1002%2fppul.24597
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Flashner&issn=1099-0496&title=Pediatric+Pulmonology&atitle=Obesity%2C+sedentary+lifestyle%2C+and+exhaled+nitric+oxide+in+an+early+adolescent+cohort.&volume=55&issue=2&spage=503&epage=509&date=2020&doi=10.1002%2Fppul.24597&pmid=31805224&sid=OVID:medline
+
+<1492>
+Unique Identifier
+ 31791636
+Title
+ Association between dairy product consumption and hyperuricemia in an elderly population with metabolic syndrome.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(2):214-222, 2020 02 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mena-Sanchez G; Babio N; Becerra-Tomas N; Martinez-Gonzalez MA; Diaz-Lopez A; Corella D; Zomeno MD; Romaguera D; Vioque J; Alonso-Gomez AM; Warnberg J; Martinez JA; Serra-Majem L; Estruch R; Bernal R; Lapetra J; Pinto X; Tur JA; Lopez-Miranda J; Cano-Ibanez N; Gaforio JJ; Matia-Martin P; Daimiel L; Caro JLL; Vidal J; Vazquez C; Ros E; Arellano AG; Palau A; Fernandez-Carrion R; Perez-Vega KA; Morey M; de la Hera MG; Vaquero-Luna J; Carmona-Gonzalez FJ; Abete I; Alvarez-Perez J; Casas R; Fernandez-Garcia JC; Santos-Lozano JM; Corbella E; Sureda A; Ruiz-Canela M; Barragan R; Goday A; Martin M; Altozano Rodado MC; Toledo E; Fito M; Salas-Salvado J
+Corporate Author
+ PREDIMED-PLUS investigators
+Authors Full Name
+ Mena-Sanchez, Guillermo; Babio, Nancy; Becerra-Tomas, Nerea; Martinez-Gonzalez, Miguel A; Diaz-Lopez, Andres; Corella, Dolores; Zomeno, Maria D; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, Jose A; Serra-Majem, Luis; Estruch, Ramon; Bernal, Rosa; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Lopez-Miranda, Jose; Cano-Ibanez, Naomi; Gaforio, Jose J; Matia-Martin, Pilar; Daimiel, Lidia; Caro, Jose L Llisterri; Vidal, Josep; Vazquez, Clotilde; Ros, Emili; Arellano, Ana Garcia; Palau, Antoni; Fernandez-Carrion, Rebeca; Perez-Vega, Karla A; Morey, Marga; de la Hera, Manoli Garcia; Vaquero-Luna, Jessica; Carmona-Gonzalez, Francisco J; Abete, Itziar; Alvarez-Perez, Jacqueline; Casas, Rosa; Fernandez-Garcia, Jose C; Santos-Lozano, Jose M; Corbella, Emili; Sureda, Antoni; Ruiz-Canela, Miguel; Barragan, Rocio; Goday, Albert; Martin, Marian; Altozano Rodado, Maria C; Toledo, Estefania; Fito, Montse; Salas-Salvado, Jordi.
+Institution
+ Mena-Sanchez, Guillermo. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, IISPV, Hospital Universitari Sant Joan de Reus, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Babio, Nancy. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, IISPV, Hospital Universitari Sant Joan de Reus, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: nancy.babio@urv.cat.
+ Becerra-Tomas, Nerea. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, IISPV, Hospital Universitari Sant Joan de Reus, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Martinez-Gonzalez, Miguel A. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, Pamplona, Spain; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Diaz-Lopez, Andres. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, IISPV, Hospital Universitari Sant Joan de Reus, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Corella, Dolores. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine, University of Valencia, Valencia, Spain.
+ Zomeno, Maria D. Cardiovascular Risk and Nutrition research group (CARIN), Hospital del Mar Research Institute (IMIM), Barcelona, Spain; Blanquerna, School of Health Sciences, Universitat Ramon Llull, Barcelona, Spain.
+ Romaguera, Dora. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Epidemiology and Public Health Department, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain.
+ Vioque, Jesus. CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Miguel Hernandez University, ISABIAL-FISABIO, Alicante, Spain.
+ Alonso-Gomez, Angel M. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Cardiology, Organizacion Sanitaria Integrada (OSI) ARABA, University Hospital Araba, Vitoria-Gasteiz, Spain.
+ Warnberg, Julia. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Nursing, School of Health Sciences, University of Malaga-IBIMA, Malaga, Spain.
+ Martinez, Jose A. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; University of Navarra, Department of Nutrition, Food Science and Physiology, IDISNA, Pamplona, Spain; Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain.
+ Serra-Majem, Luis. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; University of Las Palmas de Gran Canaria, Research Institute of Biomedical and Health Sciences (IUIBS), Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas, Spain.
+ Estruch, Ramon. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
+ Bernal, Rosa. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Virgen de la Victoria Hospital, Department of Endocrinology, University of Malaga, Malaga, Spain.
+ Lapetra, Jose. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Family Medicine, Research Unit, Distrito Sanitario Atencion Primaria Sevilla, Sevilla, Spain.
+ Pinto, Xavier. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
+ Tur, Josep A. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, Palma de Mallorca, Spain.
+ Lopez-Miranda, Jose. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.
+ Cano-Ibanez, Naomi. CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine, University of Granada, Granada, Spain.
+ Gaforio, Jose J. CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Departamento de Ciencias de la Salud, Centro de Estudios Avanzados en Olivar y Aceites de Oliva, Universidad de Jaen, Jaen, Spain.
+ Matia-Martin, Pilar. Department of Endocrinology and Nutrition, Instituto de Investigacion Sanitaria Hospital Clinico San Carlos (IdISSC), Madrid, Spain.
+ Daimiel, Lidia. Nutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain.
+ Caro, Jose L Llisterri. Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain; CIBER Diabetes y enfermedades Metabolicos (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Vidal, Josep. Departament of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
+ Vazquez, Clotilde. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Fundacion Jimenez-Diaz, Madrid, Spain.
+ Ros, Emili. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain.
+ Arellano, Ana Garcia. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, Pamplona, Spain.
+ Palau, Antoni. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, IISPV, Hospital Universitari Sant Joan de Reus, Spain.
+ Fernandez-Carrion, Rebeca. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine, University of Valencia, Valencia, Spain.
+ Perez-Vega, Karla A. Cardiovascular Risk and Nutrition research group (CARIN), Hospital del Mar Research Institute (IMIM), Barcelona, Spain.
+ Morey, Marga. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Epidemiology and Public Health Department, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain.
+ de la Hera, Manoli Garcia. CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Miguel Hernandez University, ISABIAL-FISABIO, Alicante, Spain.
+ Vaquero-Luna, Jessica. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Cardiology, Organizacion Sanitaria Integrada (OSI) ARABA, University Hospital Araba, Vitoria-Gasteiz, Spain.
+ Carmona-Gonzalez, Francisco J. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Unidad Gestion Clinica de Torrequebrada, Distrito Atencion Primaria Costa del Sol, Servicio Andaluz de Salud, Spain.
+ Abete, Itziar. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; University of Navarra, Department of Nutrition, Food Science and Physiology, IDISNA, Pamplona, Spain.
+ Alvarez-Perez, Jacqueline. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; University of Las Palmas de Gran Canaria, Research Institute of Biomedical and Health Sciences (IUIBS), Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas, Spain.
+ Casas, Rosa. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
+ Fernandez-Garcia, Jose C. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Virgen de la Victoria Hospital, Department of Endocrinology, University of Malaga, Malaga, Spain.
+ Santos-Lozano, Jose M. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Family Medicine, Research Unit, Distrito Sanitario Atencion Primaria Sevilla, Sevilla, Spain.
+ Corbella, Emili. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
+ Sureda, Antoni. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, Palma de Mallorca, Spain.
+ Ruiz-Canela, Miguel. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, Pamplona, Spain.
+ Barragan, Rocio. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine, University of Valencia, Valencia, Spain.
+ Goday, Albert. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Cardiovascular Risk and Nutrition research group (CARIN), Hospital del Mar Research Institute (IMIM), Barcelona, Spain; Department of Medicine, Universitat Autonoma de Barcelona, Endocrinology Unit, Hospital del Mar, Barcelona, Spain.
+ Martin, Marian. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Epidemiology and Public Health Department, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain.
+ Altozano Rodado, Maria C. CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Miguel Hernandez University, ISABIAL-FISABIO, Alicante, Spain.
+ Toledo, Estefania. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, Pamplona, Spain.
+ Fito, Montse. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Cardiovascular Risk and Nutrition research group (CARIN), Hospital del Mar Research Institute (IMIM), Barcelona, Spain.
+ Salas-Salvado, Jordi. Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, IISPV, Hospital Universitari Sant Joan de Reus, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jordi.salas@urv.cat.
+MeSH Subject Headings
+ Age Factors
+ Aged
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ *Dairy Products
+ *Diet, Fat-Restricted
+ *Diet, Healthy
+ Female
+ Humans
+ Hyperuricemia/bl [Blood]
+ Hyperuricemia/di [Diagnosis]
+ Hyperuricemia/ep [Epidemiology]
+ *Hyperuricemia/pc [Prevention & Control]
+ Male
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ Nutritive Value
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Randomized Controlled Trials as Topic
+ Recommended Dietary Allowances
+ Risk Assessment
+ Risk Factors
+ *Risk Reduction Behavior
+ Spain/ep [Epidemiology]
+ *Uric Acid/bl [Blood]
+Keyword Heading
+ Cheese
+ Dairy products
+ Hyperuricemia
+ Milk
+ Yogurt
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: The prevalence of hyperuricemia has increased substantially in recent decades. It has been suggested that it is an independent risk factor for weight gain, hypertension, hypertriglyceridemia, metabolic syndrome (MetS), and cardiovascular disease. Results from epidemiological studies conducted in different study populations have suggested that high consumption of dairy products is associated with a lower risk of developing hyperuricemia. However, this association is still unclear. The aim of the present study is to explore the association of the consumption of total dairy products and their subtypes with the risk of hyperuricemia in an elderly Mediterranean population with MetS.
+
+ METHODS AND RESULTS: Baseline cross-sectional analyses were conducted on 6329 men/women (mean age 65 years) with overweight/obesity and MetS from the PREDIMED-Plus cohort. Dairy consumption was assessed using a food frequency questionnaire. Multivariable-adjusted Cox regressions were fitted to analyze the association of quartiles of consumption of total dairy products and their subtypes with the prevalence of hyperuricemia. Participants in the upper quartile of the consumption of total dairy products (multiadjusted prevalence ratio (PR) = 0.84; 95% CI: 0.75-0.94; P-trend 0.02), low-fat dairy products (PR = 0.79; 95% CI: 0.70-0.89; P-trend <0.001), total milk (PR = 0.81; 95% CI: 0.73-0.90; P-trend<0.001), low-fat milk (PR = 0.80; 95% CI: 0.72-0.89; P-trend<0.001, respectively), low-fat yogurt (PR = 0.89; 95% CI: 0.80-0.98; P-trend 0.051), and cheese (PR = 0.86; 95% CI: 0.77-0.96; P-trend 0.003) presented a lower prevalence of hyperuricemia. Whole-fat dairy, fermented dairy, and yogurt consumption were not associated with hyperuricemia.
+
+ CONCLUSIONS: High consumption of total dairy products, total milk, low-fat dairy products, low-fat milk, low-fat yogurt, and cheese is associated with a lower risk of hyperuricemia. Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.numecd.2019.09.023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mena-Sanchez&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Association+between+dairy+product+consumption+and+hyperuricemia+in+an+elderly+population+with+metabolic+syndrome.&volume=30&issue=2&spage=214&epage=222&date=2020&doi=10.1016%2Fj.numecd.2019.09.023&pmid=31791636&sid=OVID:medline
+
+<1493>
+Unique Identifier
+ 31785257
+Title
+ Adiponectin and leptin in the diagnosis and therapy of NAFLD.
+Source
+ Metabolism: Clinical & Experimental. 103:154028, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Boutari C; Mantzoros CS
+Authors Full Name
+ Boutari, Chrysoula; Mantzoros, Christos S.
+Institution
+ Boutari, Chrysoula. Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
+ Mantzoros, Christos S. Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Section of Endocrinology, Diabetes and Metabolism, Boston VA Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA. Electronic address: cmantzor@bidmc.harvard.edu.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ *Adiponectin/ph [Physiology]
+ Biomarkers/bl [Blood]
+ Humans
+ Leptin/bl [Blood]
+ *Leptin/ph [Physiology]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/th [Therapy]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/th [Therapy]
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Editorial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.metabol.2019.154028
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Boutari&issn=0026-0495&title=Metabolism%3A+Clinical+%26+Experimental&atitle=Adiponectin+and+leptin+in+the+diagnosis+and+therapy+of+NAFLD.&volume=103&issue=&spage=154028&epage=&date=2020&doi=10.1016%2Fj.metabol.2019.154028&pmid=31785257&sid=OVID:medline
+
+<1494>
+Unique Identifier
+ 31761419
+Title
+ Urinary angiotensinogen increases in the absence of overt renal injury in high fat diet-induced type 2 diabetic mice.
+Source
+ Journal of Diabetes & its Complications. 34(2):107448, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Reverte V; Gogulamudi VR; Rosales CB; Musial DC; Gonsalez SR; Parra-Vitela AJ; Galeas-Pena M; Sure VN; Visniauskas B; Lindsey SH; Katakam PVG; Prieto MC
+Authors Full Name
+ Reverte, Virginia; Gogulamudi, Venkateswara R; Rosales, Carla B; Musial, Diego C; Gonsalez, Sabrina R; Parra-Vitela, Alberto J; Galeas-Pena, Michelle; Sure, Venkata N; Visniauskas, Bruna; Lindsey, Sarah H; Katakam, Prasad V G; Prieto, Minolfa C.
+Institution
+ Reverte, Virginia. Department of Physiology, Tulane University School of Medicine, New Orleans, USA.
+ Gogulamudi, Venkateswara R. Department of Physiology, Tulane University School of Medicine, New Orleans, USA.
+ Rosales, Carla B. Department of Physiology, Tulane University School of Medicine, New Orleans, USA.
+ Musial, Diego C. Department of Physiology, Tulane University School of Medicine, New Orleans, USA; Department of Pharmacology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
+ Gonsalez, Sabrina R. Department of Physiology, Tulane University School of Medicine, New Orleans, USA; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
+ Parra-Vitela, Alberto J. Department of Physiology, Tulane University School of Medicine, New Orleans, USA.
+ Galeas-Pena, Michelle. Department of Physiology, Tulane University School of Medicine, New Orleans, USA.
+ Sure, Venkata N. Department of Pharmacology, Tulane University School of Medicine, New Orleans, USA.
+ Visniauskas, Bruna. Department of Physiology, Tulane University School of Medicine, New Orleans, USA.
+ Lindsey, Sarah H. Department of Pharmacology, Tulane University School of Medicine, New Orleans, USA.
+ Katakam, Prasad V G. Department of Pharmacology, Tulane University School of Medicine, New Orleans, USA.
+ Prieto, Minolfa C. Department of Physiology, Tulane University School of Medicine, New Orleans, USA; Hypertension and Renal Center of Excellence, New Orleans, USA. Electronic address: mprieto@tulane.edu.
+MeSH Subject Headings
+ Albuminuria
+ *Angiotensinogen/ur [Urine]
+ Animals
+ Biomarkers/ur [Urine]
+ Diabetes Mellitus, Experimental/et [Etiology]
+ Diabetes Mellitus, Experimental/pp [Physiopathology]
+ Diabetes Mellitus, Experimental/ur [Urine]
+ *Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Diabetes Mellitus, Type 2/ur [Urine]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Hypertension/co [Complications]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/co [Complications]
+ *Renin-Angiotensin System/ph [Physiology]
+Keyword Heading
+ Albuminuria
+ Blood pressure
+ Diabetes mellitus
+ Hyperglycemia
+ Intrarenal renin-angiotensin system
+ Kidney
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM OF THE STUDY: During type 2 diabetes (T2D) and hypertension there is stimulation of renal proximal tubule angiotensinogen (AGT), but whether urinary excretion of AGT (uAGT) is an indicator of glomerular damage or intrarenal RAS activation is unclear. We tested the hypothesis that elevations in uAGT can be detected in the absence of albuminuria in a mouse model of T2D.
+
+ METHODS: Male C57BL/6 mice (N=10) were fed a high fat (HFD; 45% Kcal from fat) for 28weeks, and the metabolic phenotype including body weight, blood pressures, glucose, insulin, ippGTT, HOMA-IR, and cholesterol was examined. In addition, kidney Ang II content and reactive oxygen species (ROS) was measured along with urinary albumin, creatinine, Ang II, and AGT.
+
+ RESULTS: All parameters consistent with T2D were present in mice after 12-14weeks on the HFD. Systolic BP increased after 18weeks in HFD but not NFD mice. Intrarenal ROS and Ang II concentrations were also increased in HFD mice. Remarkably, these changes paralleled the augmentation uAGT excretion (3.66+/-0.50 vs. 0.92+/-0.13ng/mg by week 29; P<0.01), which occurred in the absence of overt albuminuria.
+
+ CONCLUSIONS: In HFD-induced T2D mice, increases in uAGT occur in the absence of overt renal injury, indicating that this biomarker accurately detects early intrarenal RAS activation. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 11002-13-4 (Angiotensinogen).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.jdiacomp.2019.107448
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Reverte&issn=1056-8727&title=Journal+of+Diabetes+%26+its+Complications&atitle=Urinary+angiotensinogen+increases+in+the+absence+of+overt+renal+injury+in+high+fat+diet-induced+type+2+diabetic+mice.&volume=34&issue=2&spage=107448&epage=&date=2020&doi=10.1016%2Fj.jdiacomp.2019.107448&pmid=31761419&sid=OVID:medline
+
+<1495>
+Unique Identifier
+ 31759583
+Title
+ Fitness and Fatness Are Both Associated with Cardiometabolic Risk in Preadolescents.
+Source
+ Journal of Pediatrics. 217:39-45.e1, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stoner L; Pontzer H; Barone Gibbs B; Moore JB; Castro N; Skidmore P; Lark S; Williams MA; Hamlin MJ; Faulkner J
+Authors Full Name
+ Stoner, Lee; Pontzer, Herman; Barone Gibbs, Bethany; Moore, Justin B; Castro, Nicholas; Skidmore, Paula; Lark, Sally; Williams, Michelle A; Hamlin, Michael J; Faulkner, James.
+Institution
+ Stoner, Lee. Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: dr.l.stoner@gmail.com.
+ Pontzer, Herman. Department of Evolutionary Anthropology, Duke University, Durham, NC; Duke Global Health Institute, Duke University, Durham, NC.
+ Barone Gibbs, Bethany. Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA.
+ Moore, Justin B. Department of Family & Community Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
+ Castro, Nicholas. School of Sport & Exercise, Massey University, Wellington, NZ; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS.
+ Skidmore, Paula. Department of Medicine, University of Otago, Christhcurch, NZ.
+ Lark, Sally. School of Sport & Exercise, Massey University, Wellington, NZ.
+ Williams, Michelle A. Depepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Hamlin, Michael J. Department of Tourism, Sport and Society, Lincoln University, Christchurch, NZ.
+ Faulkner, James. Sport & Exercise, University of Winchester, Winchester, United Kingdom.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Blood Pressure
+ Body Mass Index
+ Body Weight
+ *Cardiovascular Diseases/co [Complications]
+ *Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/pp [Physiopathology]
+ Child
+ Cross-Sectional Studies
+ Female
+ Humans
+ Male
+ New Zealand/ep [Epidemiology]
+ New Zealand/eh [Ethnology]
+ *Obesity/co [Complications]
+ Obesity/eh [Ethnology]
+ Obesity/pc [Prevention & Control]
+ *Overweight/co [Complications]
+ Overweight/eh [Ethnology]
+ Overweight/pc [Prevention & Control]
+ Oxygen
+ Oxygen Consumption
+ *Physical Fitness
+ Risk Assessment
+ Risk Factors
+Keyword Heading
+ body weight
+ cardiorespiratory fitness
+ cardiovascular disease
+ metabolic disease
+ youth
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To determine the associations between cardiorespiratory fitness (CRF) and fatness (overweight-obesity) with cardiometabolic disease risk among preadolescent children.
+
+ STUDY DESIGN: This cross-sectional study recruited 392 children (50% female, 8-10 years of age). Overweight-obesity was classified according to 2007 World Health Organization criteria for body mass index. High CRF was categorized as a maximum oxygen uptake, determined using a shuttle run test, exceeding 35 mL.kg-1.minute-1 in girls and 42 mL.kg-1.minute-1 in boys. Eleven traditional and novel cardiometabolic risk factors were measured including lipids, glucose, glycated hemoglobin, peripheral and central blood pressure, and arterial wave reflection. Factor analysis identified underlying cardiometabolic disease risk factors and a cardiometabolic disease risk summary score. Two-way analysis of covariance determined the associations between CRF and fatness with cardiometabolic disease risk factors.
+
+ RESULTS: Factor analysis revealed four underlying factors: blood pressure, cholesterol, vascular health, and carbohydrate-metabolism. Only CRF was significantly (P = .001) associated with the blood pressure factor. Only fatness associated with vascular health (P = .010) and carbohydrate metabolism (P = .005) factors. For the cardiometabolic disease risk summary score, there was an interaction effect. High CRF was associated with decreased cardiometabolic disease risk in overweight-obese but not normal weight children (P = .006). Conversely, high fatness was associated with increased cardiometabolic disease risk in low fit but not high fit children (P < .001).
+
+ CONCLUSIONS: In preadolescent children, CRF and fatness explain different components of cardiometabolic disease risk. However, high CRF may moderate the relationship between fatness and cardiometabolic disease risk.
+
+ TRIAL REGISTRATION: ACTRN 12614000433606. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). S88TT14065 (Oxygen).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.jpeds.2019.09.076
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stoner&issn=0022-3476&title=Journal+of+Pediatrics&atitle=Fitness+and+Fatness+Are+Both+Associated+with+Cardiometabolic+Risk+in+Preadolescents.&volume=217&issue=&spage=39&epage=45.e1&date=2020&doi=10.1016%2Fj.jpeds.2019.09.076&pmid=31759583&sid=OVID:medline
+
+<1496>
+Unique Identifier
+ 31754687
+Title
+ High Compared with Moderate Protein Intake Reduces Adaptive Thermogenesis and Induces a Negative Energy Balance during Long-term Weight-Loss Maintenance in Participants with Prediabetes in the Postobese State: A PREVIEW Study.
+Source
+ Journal of Nutrition. 150(3):458-463, 2020 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Drummen M; Tischmann L; Gatta-Cherifi B; Fogelholm M; Raben A; Adam TC; Westerterp-Plantenga MS
+Authors Full Name
+ Drummen, Mathijs; Tischmann, Lea; Gatta-Cherifi, Blandine; Fogelholm, Mikael; Raben, Anne; Adam, Tanja C; Westerterp-Plantenga, Margriet S.
+Institution
+ Drummen, Mathijs. Faculty of Health, Medicine and Life Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht UMC+, Maastricht University, Maastricht, Netherlands.
+ Tischmann, Lea. Faculty of Health, Medicine and Life Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht UMC+, Maastricht University, Maastricht, Netherlands.
+ Gatta-Cherifi, Blandine. Department of Endocrinology, Diabetology and Nutrition, Universite de Bordeaux, Bordeaux, France.
+ Fogelholm, Mikael. Department of Food and Nutrition Sciences, University of Helsinki, Helsinki, Finland.
+ Raben, Anne. Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
+ Adam, Tanja C. Faculty of Health, Medicine and Life Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht UMC+, Maastricht University, Maastricht, Netherlands.
+ Westerterp-Plantenga, Margriet S. Faculty of Health, Medicine and Life Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht UMC+, Maastricht University, Maastricht, Netherlands.
+MeSH Subject Headings
+ Aged
+ Biomarkers/ur [Urine]
+ *Dietary Proteins/ad [Administration & Dosage]
+ *Energy Metabolism
+ Female
+ Humans
+ Male
+ Middle Aged
+ Nutritional Physiological Phenomena
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ *Prediabetic State/me [Metabolism]
+ Prediabetic State/pp [Physiopathology]
+ *Thermogenesis
+ *Weight Loss
+Keyword Heading
+ adaptive thermogenesis
+ energy balance
+ energy expenditure
+ obesity
+ protein
+ weight loss
+ weight maintenance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Weight loss has been associated with adaptations in energy expenditure. Identifying factors that counteract these adaptations are important for long-term weight loss and weight maintenance.
+
+ OBJECTIVE: The aim of this study was to investigate whether increased protein/carbohydrate ratio would reduce adaptive thermogenesis (AT) and the expected positive energy balance (EB) during weight maintenance after weight loss in participants with prediabetes in the postobese state.
+
+ METHODS: In 38 participants, the effects of 2 diets differing in protein/carbohydrate ratio on energy expenditure and respiratory quotient (RQ) were assessed during 48-h respiration chamber measurements ~34 mo after weight loss. Participants consumed a high-protein (HP) diet (n = 20; 13 women/7 men; age: 64.0 +/- 6.2 y; BMI: 28.9 +/- 4.0 kg/m 2) with 25:45:30% or a moderate-protein (MP) diet (n = 18; 9 women/9 men; age: 65.1 +/- 5.8 y; BMI: 29.0 +/- 3.8 kg/m 2) with 15:55:30% of energy from protein:carbohydrate:fat. Predicted resting energy expenditure (REEp) was calculated based on fat-free mass and fat mass. AT was assessed by subtracting measured resting energy expenditure (REE) from REEp. The main outcomes included differences in components of energy expenditure, substrate oxidation, and AT between groups.
+
+ RESULTS: EB (MP = 0.2 +/- 0.9 MJ/d; HP = -0.5 +/- 0.9 MJ/d) and RQ (MP = 0.84 +/- 0.02; HP = 0.82 +/- 0.02) were reduced and REE (MP: 7.3 +/- 0.2 MJ/d compared with HP: 7.8 +/- 0.2 MJ/d) was increased in the HP group compared with the MP group (P < 0.05). REE was not different from REEp in the HP group, whereas REE was lower than REEp in the MP group (P < 0.05). Furthermore, EB was positively related to AT (rs = 0.74; P < 0.001) and RQ (rs = 0.47; P < 0.01) in the whole group of participants.
+
+ CONCLUSIONS: In conclusion, an HP diet compared with an MP diet led to a negative EB and counteracted AT ~34 mo after weight loss, in participants with prediabetes in the postobese state. These results indicate the relevance of compliance to an increased protein/carbohydrate ratio for long-term weight maintenance after weight loss. The trial was registered at clinicaltrials.gov as NCT01777893. Copyright © The Author(s) 2019.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1093%2fjn%2fnxz281
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Drummen&issn=0022-3166&title=Journal+of+Nutrition&atitle=High+Compared+with+Moderate+Protein+Intake+Reduces+Adaptive+Thermogenesis+and+Induces+a+Negative+Energy+Balance+during+Long-term+Weight-Loss+Maintenance+in+Participants+with+Prediabetes+in+the+Postobese+State%3A+A+PREVIEW+Study.&volume=150&issue=3&spage=458&epage=463&date=2020&doi=10.1093%2Fjn%2Fnxz281&pmid=31754687&sid=OVID:medline
+
+<1497>
+Unique Identifier
+ 31753785
+Title
+ A higher glycemic response to oral glucose is associated with higher plasma apolipoprotein C3 independently of BMI in healthy twins.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 30(3):459-466, 2020 03 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bozzetto L; Berntzen BJ; Kaprio J; Rissanen A; Taskinen MR; Pietilainen KH
+Authors Full Name
+ Bozzetto, Lutgarda; Berntzen, Bram J; Kaprio, Jaakko; Rissanen, Aila; Taskinen, Marja-Riitta; Pietilainen, Kirsi H.
+Institution
+ Bozzetto, Lutgarda. Department of Clinical Medicine and Surgery, Federico II University Naples, Italy. Electronic address: lutgarda.bozzetto@unina.it.
+ Berntzen, Bram J. Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
+ Kaprio, Jaakko. Department of Public Health, Finnish Twin Cohort Study, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.
+ Rissanen, Aila. Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
+ Taskinen, Marja-Riitta. Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
+ Pietilainen, Kirsi H. Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Obesity Center, Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ *Apolipoprotein C-III/bl [Blood]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ Female
+ Finland
+ *Glucose Metabolism Disorders/bl [Blood]
+ Glucose Metabolism Disorders/di [Diagnosis]
+ Glucose Metabolism Disorders/ge [Genetics]
+ Glucose Metabolism Disorders/pp [Physiopathology]
+ *Glucose Tolerance Test
+ Healthy Volunteers
+ Humans
+ Male
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ Risk Factors
+ Time Factors
+ Triglycerides/bl [Blood]
+ Twins, Monozygotic/ge [Genetics]
+ Young Adult
+Keyword Heading
+ Apolipoprotein C3
+ Glucose metabolism
+ Obesity
+ Plasma triglyceride
+ Twins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Plasma apolipoprotein C3 (ApoC3) is associated with higher plasma triglyceride and type 2 diabetes incidence. We evaluated whether body mass index (BMI) or glucose metabolism were associated with ApoC3 in healthy monozygotic (MZ) twins.
+
+ METHODS AND RESULTS: Forty-seven MZ twin-pairs (20 man, 27 women), aged 23-42 years, were divided in subgroups according to discordance or concordance for (a) BMI (within-pair difference (DELTA) in BMI>=3.0 or<3.0 kg/m2), or (b) 2-h glucose iAUC, during oral glucose tolerance test (DELTAGlucose iAUC >=97.5 or<97.5 mmol x 120 minutes). Within these discordant or concordant subgroups, we tested (Wilcoxon signed-rank test) co-twin differences in ApoC3, adiposity measures, insulin-resistance and beta-cell function indices, and plasma and lipoprotein lipids. In BMI-Discordant (p = 0.92) or BMI-Concordant (p = 0.99) subgroups, ApoC3 did not differ between leaner and heavier co-twins. In the Glucose-Discordant subgroup, ApoC3 was significantly higher in twins with higher Glucose iAUC than in their co-twins with the lower Glucose iAUC (10.03 +/- 0.78 vs. 8.48 +/- 0.52 mg/dl; M +/- SE; p = 0.032). Co-twins with higher Glucose iAUC also had higher waist circumference, body fat percentage, liver fat content, worse insulin-sensitivity and beta-cell function and higher cholesterol and triglyceride in plasma VLDL, IDL, and LDL. In Glucose-Concordant twin-pairs, no significant differences were observed in the explored variables. In all twin-pairs, DELTAApoC3 correlated with DELTA in lipids and glucose metabolism variables, the closest relationship being between DELTAApoC3 and DELTAVLDL triglyceride (r = 0.74, p < 0.0001).
+
+ CONCLUSIONS: While ApoC3 was not related to acquired differences in BMI, it associated with early dysregulation of glucose metabolism independently of obesity and genetic background. Copyright © 2019. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (APOC3 protein, human). 0 (Apolipoprotein C-III). 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Twin Study.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.numecd.2019.10.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bozzetto&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=A+higher+glycemic+response+to+oral+glucose+is+associated+with+higher+plasma+apolipoprotein+C3+independently+of+BMI+in+healthy+twins.&volume=30&issue=3&spage=459&epage=466&date=2020&doi=10.1016%2Fj.numecd.2019.10.005&pmid=31753785&sid=OVID:medline
+
+<1498>
+Unique Identifier
+ 31752058
+Title
+ Roles of Protein Histidine Phosphatase 1 (PHPT1) in Brown Adipocyte Differentiation.
+Source
+ Journal of Microbiology & Biotechnology. 30(2):306-312, 2020 Feb 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kang JA; Kang HS; Bae KH; Lee SC; Oh KJ; Kim WK
+Authors Full Name
+ Kang, Joo Ae; Kang, Hyun Sup; Bae, Kwang-Hee; Lee, Sang Chul; Oh, Kyoung-Jin; Kim, Won Kon.
+Institution
+ Kang, Joo Ae. Metabolic Regulation Research Center, KRIBB, Daejeon 34141, Republic of Korea.
+ Kang, Joo Ae. Department of Functional Genomics, University of Science and Technology (UST), UST-KRIBB School, Daejeon 34141, Republic of Korea.
+ Kang, Hyun Sup. Metabolic Regulation Research Center, KRIBB, Daejeon 34141, Republic of Korea.
+ Kang, Hyun Sup. Department of Functional Genomics, University of Science and Technology (UST), UST-KRIBB School, Daejeon 34141, Republic of Korea.
+ Bae, Kwang-Hee. Metabolic Regulation Research Center, KRIBB, Daejeon 34141, Republic of Korea.
+ Bae, Kwang-Hee. Department of Functional Genomics, University of Science and Technology (UST), UST-KRIBB School, Daejeon 34141, Republic of Korea.
+ Lee, Sang Chul. Metabolic Regulation Research Center, KRIBB, Daejeon 34141, Republic of Korea.
+ Lee, Sang Chul. Department of Functional Genomics, University of Science and Technology (UST), UST-KRIBB School, Daejeon 34141, Republic of Korea.
+ Oh, Kyoung-Jin. Metabolic Regulation Research Center, KRIBB, Daejeon 34141, Republic of Korea.
+ Oh, Kyoung-Jin. Department of Functional Genomics, University of Science and Technology (UST), UST-KRIBB School, Daejeon 34141, Republic of Korea.
+ Kim, Won Kon. Metabolic Regulation Research Center, KRIBB, Daejeon 34141, Republic of Korea.
+ Kim, Won Kon. Department of Functional Genomics, University of Science and Technology (UST), UST-KRIBB School, Daejeon 34141, Republic of Korea.
+MeSH Subject Headings
+ *Adipocytes, Brown/cy [Cytology]
+ *Adipocytes, Brown/me [Metabolism]
+ Adipogenesis/ge [Genetics]
+ Animals
+ Biomarkers
+ *Cell Differentiation/ge [Genetics]
+ Ectopic Gene Expression
+ Gene Expression
+ Gene Knockdown Techniques
+ HEK293 Cells
+ *Histidine/me [Metabolism]
+ Humans
+ Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Phosphorylation
+ *Protein Phosphatase 1/ge [Genetics]
+ Protein Phosphatase 1/me [Metabolism]
+ RNA, Messenger
+Keyword Heading
+ Brown adipogenesis
+ PHPT1
+ histidine phosphorylation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Despite the importance of brown adipocytes as a therapeutic target for the prevention and treatment of obesity, the molecular mechanism underlying brown adipocyte differentiation is not fully understood. In particular, the role of post-translational modifications in brown adipocyte differentiation has not been extensively studied. Histidine phosphorylation is increasingly recognized an important process for protein post-translational modifications. In this study, we show that histidine phosphorylation patterns change during brown adipocyte differentiation. In addition, the expression level of protein histidine phosphatase 1 (PHPT1), a major mammalian phosphohistidine phosphatase, is reduced rapidly at the early phase of differentiation and recovers at the later phase. During white adipocyte differentiation of 3T3- L1 preadipocytes, however, the expression level of PHPT1 do not significantly change. Knockdown of PHPT1 promotes brown adipocyte differentiation, whereas ectopic expression of PHPT1 suppresses brown adipocyte differentiation. These results collectively suggest that histidine phosphorylation is closely linked to brown adipocyte differentiation and could be a therapeutic target for obesity and related metabolic diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Messenger). 4QD397987E (Histidine). EC 3-1-3-16 (Protein Phosphatase 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.4014%2fjmb.1909.09003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kang&issn=1017-7825&title=Journal+of+Microbiology+%26+Biotechnology&atitle=Roles+of+Protein+Histidine+Phosphatase+1+%28PHPT1%29+in+Brown+Adipocyte+Differentiation.&volume=30&issue=2&spage=306&epage=312&date=2020&doi=10.4014%2Fjmb.1909.09003&pmid=31752058&sid=OVID:medline
+
+<1499>
+Unique Identifier
+ 31745938
+Title
+ Mouse Models to Study Antiobesogenic Effects of Carotenoids.
+Source
+ Methods in Molecular Biology. 2083:403-417, 2020.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ribot J; Stojnic B; Palou A; Bonet ML
+Authors Full Name
+ Ribot, Joan; Stojnic, Bojan; Palou, Andreu; Bonet, M Luisa.
+Institution
+ Ribot, Joan. Grup de Recerca Nutrigenomica i Obesitat, Laboratori de Biologia Molecular, Nutricio i Biotecnologia (LBNB) of the Universitat de les Illes Balears, CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and Institut d'Investigacio Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain. joan.ribot@uib.es.
+ Stojnic, Bojan. Grup de Recerca Nutrigenomica i Obesitat, Laboratori de Biologia Molecular, Nutricio i Biotecnologia (LBNB) of the Universitat de les Illes Balears, CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and Institut d'Investigacio Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
+ Palou, Andreu. Grup de Recerca Nutrigenomica i Obesitat, Laboratori de Biologia Molecular, Nutricio i Biotecnologia (LBNB) of the Universitat de les Illes Balears, CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and Institut d'Investigacio Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
+ Bonet, M Luisa. Grup de Recerca Nutrigenomica i Obesitat, Laboratori de Biologia Molecular, Nutricio i Biotecnologia (LBNB) of the Universitat de les Illes Balears, CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and Institut d'Investigacio Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
+MeSH Subject Headings
+ Animals
+ Anti-Obesity Agents/ch [Chemistry]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers
+ Blood Glucose/de [Drug Effects]
+ Body Weight/de [Drug Effects]
+ Carotenoids/ch [Chemistry]
+ *Carotenoids/pd [Pharmacology]
+ Diet
+ Disease Models, Animal
+ Humans
+ Insulin Resistance
+ Male
+ Metabolic Syndrome/dt [Drug Therapy]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Mice
+ Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+Keyword Heading
+ Animal models
+ Carotenoids
+ Metabolic syndrome
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Carotenoids entail a vast potential to tackle health problems including obesity and some of its comorbidities. The use of animal models remains necessary, particularly at early stages of research (preclinical) and for advancing in mechanistic aspects of carotenoid action. No single animal model completely mimics human absorption and metabolism of carotenoids, and the best model must be chosen considering the specific application, characteristics of the individual models, and funding and facilities available. Here, we propose three protocols in mice to investigate the potential of a given carotenoid, carotenoid mixture, or carotenoid-rich extract to (a) counteract the development of obesity and prevent the metabolic alterations caused by feeding mice a moderate high-fat diet; (b) improve the metabolic profile of obese animals with metabolic alterations caused by chronic high-fat diet feeding; and (c) act as coadjuvants in weight loss strategies (reversion to a low fat diet) applied to diet-induced obese animals.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Blood Glucose). 36-88-4 (Carotenoids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2f978-1-4939-9952-1_30
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ribot&issn=1064-3745&title=Methods+in+Molecular+Biology&atitle=Mouse+Models+to+Study+Antiobesogenic+Effects+of+Carotenoids.&volume=2083&issue=&spage=403&epage=417&date=2020&doi=10.1007%2F978-1-4939-9952-1_30&pmid=31745938&sid=OVID:medline
+
+<1500>
+Unique Identifier
+ 31713941
+Title
+ The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial.
+Source
+ Phytotherapy Research. 34(2):379-387, 2020 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Parandoosh M; Yousefi R; Khorsandi H; Nikpayam O; Saidpour A; Babaei H
+Author NameID
+ Parandoosh, Maryam; ORCID: http://orcid.org/0000-0001-8443-6837
+Authors Full Name
+ Parandoosh, Maryam; Yousefi, Reyhaneh; Khorsandi, Hoda; Nikpayam, Omid; Saidpour, Atoosa; Babaei, Hossein.
+Institution
+ Parandoosh, Maryam. Department of Clinical Nutrition & Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Yousefi, Reyhaneh. Department of Clinical Nutrition & Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Khorsandi, Hoda. Department of Clinical Nutrition & Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Nikpayam, Omid. Department of Biochemistry and Diet Therapy, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Saidpour, Atoosa. Department of Clinical Nutrition & Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Babaei, Hossein. Drug Applied Research Center, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
+MeSH Subject Headings
+ Adult
+ *Appetite/de [Drug Effects]
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Body Weight
+ C-Reactive Protein/an [Analysis]
+ Caloric Restriction
+ *Dietary Supplements
+ Double-Blind Method
+ Female
+ *Grape Seed Extract/tu [Therapeutic Use]
+ Humans
+ *Inflammation/dt [Drug Therapy]
+ Male
+ Neuropeptide Y
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Vitis
+ Waist Circumference
+ Waist-Hip Ratio
+Keyword Heading
+ NPY
+ TNF-alpha
+ grape seed extract
+ hs-CRP
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Grape seed extract (GSE) is a natural supplement known for its various health benefits, including anti-inflammatory effect. This study aimed to evaluate the effects of GSE supplementation on inflammatory markers, neuropeptide Y, anthropometric measurements, and appetite in obese or overweight individuals.
+
+ METHODS AND MATERIALS: A randomized, double-blind clinical trial was performed on 40 obese or overweight subjects who were randomly assigned to receive GSE (300 mg/day) or placebo for a period of 12-weeks. Both groups were under a restricted calorie diet (RCD)(~250 kcal lower than the estimated energy requirement). Anthropometric measurements, biochemical biomarkers and dietary intakes were determined during the study period.
+
+ RESULTS: The reductions of body weight, body mass index, waist circumference, and waist to hip ratio were significantly higher in the GSE group compared to the placebo group (P = 0.045, 0.033, 0.029, and 0.021, respectively). Lower levels of neuropeptide Y, tumor necrosis factor alpha, and high sensitivity C-reactive protein were observed in the GSE group in comparison with the placebo group (P = 0.041, 0.001, and 0.034, respectively).
+
+ CONCLUSION: GSE supplement with a RCD has favorable effects in reducing anthropometric measurements and inflammatory markers in obese or overweight individuals, and may play an effective role in the treatment of obesity. Copyright © 2019 John Wiley & Sons, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Grape Seed Extract). 0 (Neuropeptide Y). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1002%2fptr.6529
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Parandoosh&issn=0951-418X&title=Phytotherapy+Research&atitle=The+effects+of+grape+seed+extract+%28Vitis+vinifera%29+supplement+on+inflammatory+markers%2C+neuropeptide+Y%2C+anthropometric+measures%2C+and+appetite+in+obese+or+overweight+individuals%3A+A+randomized+clinical+trial.&volume=34&issue=2&spage=379&epage=387&date=2020&doi=10.1002%2Fptr.6529&pmid=31713941&sid=OVID:medline
+
+<1501>
+Unique Identifier
+ 31701685
+Title
+ Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women.
+Source
+ Diabetes & Metabolism Journal. 44(1):134-142, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang Y; Zhu J; Aroner S; Overvad K; Cai T; Yang M; Tjonneland A; Handberg A; Jensen MK
+Author NameID
+ Wang, Yeli; ORCID: https://orcid.org/0000-0003-3031-6199
+ Zhu, Jingwen; ORCID: https://orcid.org/0000-0003-1367-9537
+ Jensen, Majken K; ORCID: https://orcid.org/0000-0003-4729-7545
+Authors Full Name
+ Wang, Yeli; Zhu, Jingwen; Aroner, Sarah; Overvad, Kim; Cai, Tianxi; Yang, Ming; Tjonneland, Anne; Handberg, Aase; Jensen, Majken K.
+Institution
+ Wang, Yeli. Health Services and Systems Research, Duke-NUS Medical School, Singapore.
+ Zhu, Jingwen. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Aroner, Sarah. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Overvad, Kim. Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
+ Overvad, Kim. Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
+ Cai, Tianxi. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Yang, Ming. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Tjonneland, Anne. Danish Cancer Society Research Center, Copenhagen, Denmark.
+ Handberg, Aase. Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
+ Handberg, Aase. Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
+ Jensen, Majken K. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Jensen, Majken K. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mkjensen@hsph.harvard.edu.
+MeSH Subject Headings
+ Adiposity
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *CD36 Antigens/bl [Blood]
+ Case-Control Studies
+ Denmark/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Proportional Hazards Models
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Waist Circumference
+Keyword Heading
+ Adiposity
+ Biomarkers
+ CD36 antigens
+ Diabetes mellitus, type 2
+ Epidemiology
+ Prospective studies
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.
+
+ METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).
+
+ RESULTS: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.
+
+ CONCLUSION: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity. Copyright © 2020 Korean Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CD36 Antigens).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.4093%2fdmj.2018.0273
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=2233-6079&title=Diabetes+%26+Metabolism+Journal&atitle=Plasma+CD36+and+Incident+Diabetes%3A+A+Case-Cohort+Study+in+Danish+Men+and+Women.&volume=44&issue=1&spage=134&epage=142&date=2020&doi=10.4093%2Fdmj.2018.0273&pmid=31701685&sid=OVID:medline
+
+<1502>
+Unique Identifier
+ 31690932
+Title
+ Targeted Analysis of Three Hormonal Systems Identifies Molecules Associated with the Presence and Severity of NAFLD.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(3), 2020 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Polyzos SA; Perakakis N; Boutari C; Kountouras J; Ghaly W; Anastasilakis AD; Karagiannis A; Mantzoros CS
+Authors Full Name
+ Polyzos, Stergios A; Perakakis, Nikolaos; Boutari, Chrysoula; Kountouras, Jannis; Ghaly, Wael; Anastasilakis, Athanasios D; Karagiannis, Asterios; Mantzoros, Christos S.
+Institution
+ Polyzos, Stergios A. First Department of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
+ Perakakis, Nikolaos. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
+ Boutari, Chrysoula. Second Propaedeutic Department of Internal Medicine, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki Greece.
+ Kountouras, Jannis. Second Medical Clinic, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
+ Ghaly, Wael. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
+ Ghaly, Wael. Department of Physiology, Fayoum University, Fayoum, Egypt.
+ Anastasilakis, Athanasios D. Department of Endocrinology, 424 General Military Hospital, Thessaloniki Greece.
+ Karagiannis, Asterios. Second Propaedeutic Department of Internal Medicine, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki Greece.
+ Mantzoros, Christos S. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/an [Analysis]
+ Biopsy
+ Case-Control Studies
+ Disease Progression
+ Female
+ Follistatin-Related Proteins/an [Analysis]
+ Glicentin/an [Analysis]
+ Glucose Tolerance Test
+ Humans
+ Insulin-Like Growth Factor Binding Protein 3/an [Analysis]
+ Insulin-Like Growth Factor I/an [Analysis]
+ Liver/me [Metabolism]
+ Liver Cirrhosis/et [Etiology]
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ *Proglucagon/an [Analysis]
+ *Severity of Illness Index
+ *Somatomedins/an [Analysis]
+Keyword Heading
+ GLP-1
+ NAFLD
+ NASH
+ biomarkers
+ follistatin
+ liver steatosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: To investigate circulating levels and liver gene expression of 3 hormonal pathways associated with obesity, insulin resistance, and inflammation to identify leads towards potential diagnostic markers and therapeutic targets in patients with nonalcoholic fatty liver disease (NAFLD).
+
+ METHODS: We compared circulating levels of (1) proglucagon-derived hormones (glucagon-like peptide [GLP]-1, GLP-2, glicentin, oxyntomodulin, glucagon, major proglucagon fragment [MPGF]), (2) follistatins-activins (follistatin-like [FSTL]3, activin B), (3) IGF axis (insulin-like growth factor [IGF]-1, total and intact IGF binding protein [IGFBP]-3 and IGFBP-4, and pregnancy-associated plasma protein [PAPP]-A) in 2 studies: (1) 18 individuals with early stage NAFLD versus 14 controls (study 1; early NAFLD study) and in (2) 31 individuals with biopsy proven NAFLD (15 with simple steatosis [SS] and 16 with nonalcoholic steatohepatitis [NASH]), vs 50 controls (24 lean and 26 obese) (study 2). Liver gene expression was assessed in 22 subjects (12 controls, 5 NASH, 5 NASH-related cirrhosis).
+
+ RESULTS: Patients in early stages of NAFLD demonstrate higher fasting MPGF and lower incremental increase of glicentin during oral glucose tolerance test than controls. In more advanced stages, FSTL3 levels are higher in NASH than simple steatosis and, within NAFLD patients, in those with more severe lobular and portal inflammation. The IGF-1/intact IGFBP-3 ratio is lower in patients with liver fibrosis. Genes encoding follistatin, activin A, activin B, and the IGF-1 receptor are higher in NASH.
+
+ CONCLUSION: MPGF and glicentin may be involved in early stages of NAFLD, whereas FSTL3 and IGF-1/intact IGFBP3 in the progression to NASH and liver fibrosis respectively, suggesting potential as diagnostic markers or therapeutic targets. Copyright © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Follistatin-Related Proteins). 0 (Fstl3 protein, human). 0 (IGF1 protein, human). 0 (IGFBP3 protein, human). 0 (Insulin-Like Growth Factor Binding Protein 3). 0 (Somatomedins). 55963-74-1 (Proglucagon). 67763-96-6 (Insulin-Like Growth Factor I). 71567-77-6 (Glicentin).
+Publication Type
+ Journal Article. Observational Study. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1210%2fclinem%2fdgz172
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Polyzos&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Targeted+Analysis+of+Three+Hormonal+Systems+Identifies+Molecules+Associated+with+the+Presence+and+Severity+of+NAFLD.&volume=105&issue=3&spage=e390&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgz172&pmid=31690932&sid=OVID:medline
+
+<1503>
+Unique Identifier
+ 31678040
+Title
+ Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes. [Review]
+Source
+ Paediatric Respiratory Reviews. 36:118-127, 2020 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gans MD; Gavrilova T
+Authors Full Name
+ Gans, Melissa D; Gavrilova, Tatyana.
+Institution
+ Gans, Melissa D. Division of Allergy and Immunology, Montefiore Medical Center, 1525 Blondell Ave, Bronx, NY 10461, USA. Electronic address: mstone@montefiore.org.
+ Gavrilova, Tatyana. Division of Allergy and Immunology, Montefiore Medical Center, 1525 Blondell Ave, Bronx, NY 10461, USA. Electronic address: tgavrilo@montefiore.org.
+MeSH Subject Headings
+ Asthma/cl [Classification]
+ *Asthma/im [Immunology]
+ Asthma/pp [Physiopathology]
+ Asthma/th [Therapy]
+ Asthma, Aspirin-Induced/im [Immunology]
+ Asthma, Aspirin-Induced/pp [Physiopathology]
+ Asthma, Aspirin-Induced/th [Therapy]
+ Asthma, Exercise-Induced/im [Immunology]
+ Asthma, Exercise-Induced/pp [Physiopathology]
+ Asthma, Exercise-Induced/th [Therapy]
+ Biological Products
+ Biomarkers
+ *Cytokines/im [Immunology]
+ Eosinophilia/im [Immunology]
+ Eosinophilia/pp [Physiopathology]
+ Eosinophilia/th [Therapy]
+ Humans
+ Invasive Pulmonary Aspergillosis/im [Immunology]
+ Invasive Pulmonary Aspergillosis/pp [Physiopathology]
+ Invasive Pulmonary Aspergillosis/th [Therapy]
+ *Leukotrienes/im [Immunology]
+ Molecular Targeted Therapy
+ Obesity/im [Immunology]
+ Obesity/pp [Physiopathology]
+ Oxidative Stress/im [Immunology]
+ Phenotype
+ Respiratory Hypersensitivity/im [Immunology]
+ Respiratory Hypersensitivity/pp [Physiopathology]
+ Respiratory Hypersensitivity/th [Therapy]
+ Respiratory Sounds
+ *Th1 Cells/im [Immunology]
+ *Th2 Cells/im [Immunology]
+Keyword Heading
+ Asthma
+ Biomarkers
+ Immunology
+ Pathophysiology
+ Phenotypes
+ Review
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Asthma is a common disease in paediatrics and adults with a significant morbidity, mortality, and financial burden worldwide. Asthma is now recognized as a heterogeneous disease and emerging clinical and laboratory research has elucidated understanding of asthma's underlying immunology. The future of asthma is classifying asthma by endotype through connecting discernible characteristics with immunological mechanisms. This comprehensive review of the immunology of asthma details the currently known pathophysiology and clinical practice biomarkers in addition to forefront biologic and targeted therapies for all of the asthma endotypes. By understanding the immunology of asthma, practitioners will be able to diagnose patients by asthma endotype and provide personalized, biomarker-driven treatments to effectively control patients' asthma. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biological Products). 0 (Biomarkers). 0 (Cytokines). 0 (Leukotrienes).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.prrv.2019.08.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gans&issn=1526-0542&title=Paediatric+Respiratory+Reviews&atitle=Understanding+the+immunology+of+asthma%3A+Pathophysiology%2C+biomarkers%2C+and+treatments+for+asthma+endotypes.&volume=36&issue=&spage=118&epage=127&date=2020&doi=10.1016%2Fj.prrv.2019.08.002&pmid=31678040&sid=OVID:medline
+
+<1504>
+Unique Identifier
+ 31677208
+Title
+ beta-cell function, incretin response, and insulin sensitivity of glucose and fat metabolism in obese youth: Relationship to OGTT-time-to-glucose-peak.
+Source
+ Pediatric Diabetes. 21(1):18-27, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim JY; Tfayli H; Bacha F; Lee S; Michaliszyn SF; Yousuf S; Gebara N; Arslanian S
+Author NameID
+ Kim, Joon Young; ORCID: https://orcid.org/0000-0003-0448-1684
+ Lee, SoJung; ORCID: https://orcid.org/0000-0002-6634-6800
+ Michaliszyn, Sara F; ORCID: https://orcid.org/0000-0002-1176-9187
+ Arslanian, Silva; ORCID: https://orcid.org/0000-0002-1528-9324
+Authors Full Name
+ Kim, Joon Young; Tfayli, Hala; Bacha, Fida; Lee, SoJung; Michaliszyn, Sara F; Yousuf, Shahwar; Gebara, Nour; Arslanian, Silva.
+Institution
+ Kim, Joon Young. Department of Exercise Science, Syracuse University, Syracuse, New York.
+ Tfayli, Hala. Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
+ Bacha, Fida. Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas.
+ Lee, SoJung. Division of Sports Medicine, Graduate School of Physical Education, Kyung Hee University, Yongin, Republic of Korea.
+ Michaliszyn, Sara F. Kinesiology and Sport Science, Youngstown State University, Youngstown, Ohio.
+ Yousuf, Shahwar. Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
+ Gebara, Nour. Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
+ Arslanian, Silva. Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
+ Arslanian, Silva. Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Child
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Fatty Acids, Nonesterified/me [Metabolism]
+ Female
+ Glucose Tolerance Test
+ Humans
+ *Incretins/me [Metabolism]
+ *Insulin Resistance/ph [Physiology]
+ *Insulin Secretion/ph [Physiology]
+ *Insulin-Secreting Cells/ph [Physiology]
+ Male
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Risk Factors
+ Time Factors
+Keyword Heading
+ OGTT
+ clamp
+ glucose peak
+ insulin sensitivity
+ obesity
+ youth
+ beta-cell function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In adults, the time-to-glucose-peak at or after 30 minutes during an oral glucose tolerance test (OGTT) identifies physiologically distinct groups with differences in insulin sensitivity, beta-cell function and risk for type 2 diabetes. In obese non-diabetic adolescents, we investigated if the OGTT-time-to-glucose-peak also reflects incretin and free fatty acid (FFA) responses besides insulin sensitivity and beta-cell function, measured by the clamp.
+
+ METHODS: Obese adolescents (n = 278) were categorized according to their OGTT-time-to-glucose-peak by Early-peak (at 30 minutes) vs Late-peak (>30 minutes) groups. Body composition, visceral adipose tissue, oral disposition index and OGTT-area under the curve (AUC) were examined. A subset of 102 participants had both hyperinsulinemic-euglycemic and hyperglycemic clamps to measure in vivo insulin sensitivity, insulin secretion, and beta-cell function relative to insulin sensitivity.
+
+ RESULTS: Compared with the Early-peak group, the Late-peak group had impaired beta-cell function relative to insulin sensitivity, lower glucose-dependent insulinotropic polypeptide-AUC, and higher FFA-AUC despite higher insulin- and C-peptide-AUC. They also had lower hepatic and peripheral insulin sensitivity despite similar percent body fat and visceral adipose tissue, and had higher prevalence of impaired glucose tolerance (all P < .05).
+
+ CONCLUSIONS: In obese non-diabetic youth, those with a Late-peak vs an Early-peak glucose during an OGTT showed diminished beta-cell function, blunted incretin secretion, and lower insulin sensitivity of glucose and FFA metabolism. It remains to be determined if Late-peak glucose predicts the future development of type 2 diabetes in these high-risk youth. Copyright © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Nonesterified). 0 (Incretins).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2fpedi.12940
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1399-543X&title=Pediatric+Diabetes&atitle=beta-cell+function%2C+incretin+response%2C+and+insulin+sensitivity+of+glucose+and+fat+metabolism+in+obese+youth%3A+Relationship+to+OGTT-time-to-glucose-peak.&volume=21&issue=1&spage=18&epage=27&date=2020&doi=10.1111%2Fpedi.12940&pmid=31677208&sid=OVID:medline
+
+<1505>
+Unique Identifier
+ 31674218
+Title
+ Prevalence and risk factors of aortic stenosis and aortic sclerosis: a 21-year follow-up of middle-aged men.
+Source
+ Scandinavian Cardiovascular Journal. 54(2):115-123, 2020 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kontogeorgos S; Thunstrom E; Basic C; Hansson PO; Zhong Y; Ergatoudes C; Morales D; Mandalenakis Z; Rosengren A; Caidahl K; Fu M
+Author NameID
+ Kontogeorgos, Silvana; ORCID: http://orcid.org/0000-0002-3564-8208
+Authors Full Name
+ Kontogeorgos, Silvana; Thunstrom, Erik; Basic, Carmen; Hansson, Per-Olof; Zhong, You; Ergatoudes, Constantinos; Morales, David; Mandalenakis, Zacharias; Rosengren, Annika; Caidahl, Kenneth; Fu, Michael.
+Institution
+ Kontogeorgos, Silvana. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Kontogeorgos, Silvana. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Thunstrom, Erik. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Thunstrom, Erik. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Basic, Carmen. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Basic, Carmen. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Hansson, Per-Olof. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Hansson, Per-Olof. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Zhong, You. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Zhong, You. Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, China.
+ Ergatoudes, Constantinos. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Ergatoudes, Constantinos. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Morales, David. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Morales, David. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Mandalenakis, Zacharias. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Mandalenakis, Zacharias. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Rosengren, Annika. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Rosengren, Annika. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Caidahl, Kenneth. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Caidahl, Kenneth. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
+ Caidahl, Kenneth. Department of Molecular Medicine and Surgery, Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
+ Fu, Michael. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Fu, Michael. Region Vastra Gotaland, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+MeSH Subject Headings
+ Age Factors
+ Aged
+ Aortic Valve Stenosis/bl [Blood]
+ Aortic Valve Stenosis/dg [Diagnostic Imaging]
+ *Aortic Valve Stenosis/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ Echocardiography, Doppler
+ Follow-Up Studies
+ Heart Valve Diseases/bl [Blood]
+ Heart Valve Diseases/dg [Diagnostic Imaging]
+ *Heart Valve Diseases/ep [Epidemiology]
+ Humans
+ Hypercholesterolemia/ep [Epidemiology]
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Factors
+ Sclerosis/bl [Blood]
+ Sclerosis/dg [Diagnostic Imaging]
+ *Sclerosis/ep [Epidemiology]
+ Sex Factors
+ Sweden/ep [Epidemiology]
+ Time Factors
+ Up-Regulation
+Keyword Heading
+ Aortic stenosis
+ obesity
+ population study
+ predictors
+ prevalence
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction. There is limited knowledge about factors associated with the development of aortic stenosis. This study aimed to examine the prevalence of aortic sclerosis or stenosis in 71-years-old men and determine which risk factors at 50 years of age predict the development of aortic sclerosis or aortic stenosis. Methods. A random sample of Swedish men from the general population, born in 1943 (n = 798) were followed for 21 years. Data on clinical characteristics and laboratory values were collected in 1993. An echocardiography was performed in 2014. We used logistic regression to examine the association between baseline data and the outcome. Results. Echocardiography was performed in 535 men, and aortic sclerosis or aortic stenosis was diagnosed in 27 (5.0%). 14 persons developed aortic stenosis (2.6%). Among men with aortic sclerosis or aortic stenosis, 29.6% were obese. In multivariable stepwise regression model, body mass index (odds ratio per unit increase 1.23 (95% CI 1.10-1.38; p = .0003)) and hypercholesterolemia, combined with high sensitive C-reactive protein (odds ratio versus all other 2.66 (1.18-6.00; p = .019)) were significantly associated with increased risk of developing aortic sclerosis or aortic stenosis. Body mass index was the only factor significantly associated with a higher risk of developing aortic stenosis. Conclusion. The prevalence of either aortic sclerosis or aortic stenosis was 5% and of aortic stenosis 2.6%. Obesity and hypercholesterolemia combined with elevated high sensitive C-reactive protein at the age of 50 predicted the development of degenerative aortic sclerosis or stenosis, whilst only obesity was correlated with the occurrence of aortic stenosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1080%2f14017431.2019.1685126
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kontogeorgos&issn=1401-7431&title=Scandinavian+Cardiovascular+Journal&atitle=Prevalence+and+risk+factors+of+aortic+stenosis+and+aortic+sclerosis%3A+a+21-year+follow-up+of+middle-aged+men.&volume=54&issue=2&spage=115&epage=123&date=2020&doi=10.1080%2F14017431.2019.1685126&pmid=31674218&sid=OVID:medline
+
+<1506>
+Unique Identifier
+ 31669001
+Title
+ The interaction between prepregnancy BMI and gestational vitamin D deficiency on the risk of gestational diabetes mellitus subtypes with elevated fasting blood glucose.
+Source
+ Clinical Nutrition. 39(7):2265-2273, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shao B; Mo M; Xin X; Jiang W; Wu J; Huang M; Wang S; Muyiduli X; Si S; Shen Y; Chen Z; Yu Y
+Authors Full Name
+ Shao, Bule; Mo, Minjia; Xin, Xing; Jiang, Wen; Wu, Jinhua; Huang, Manxian; Wang, Shuojia; Muyiduli, Xiamusiye; Si, Shuting; Shen, Yu; Chen, Zexin; Yu, Yunxian.
+Institution
+ Shao, Bule. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
+ Mo, Minjia. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
+ Xin, Xing. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
+ Jiang, Wen. Department of Obstetrics and Gynecology, Zhoushan Maternal and Child Care Hospital, Zhoushan, Zhejiang, China.
+ Wu, Jinhua. Department of Obstetrics and Gynecology, Zhoushan Maternal and Child Care Hospital, Zhoushan, Zhejiang, China.
+ Huang, Manxian. Department of Obstetrics and Gynecology, Zhoushan Maternal and Child Care Hospital, Zhoushan, Zhejiang, China.
+ Wang, Shuojia. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
+ Muyiduli, Xiamusiye. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
+ Si, Shuting. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
+ Shen, Yu. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
+ Chen, Zexin. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
+ Yu, Yunxian. Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. Electronic address: yunxianyu@zju.edu.cn.
+MeSH Subject Headings
+ 25-Hydroxyvitamin D 2/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ Calcifediol/bl [Blood]
+ *Diabetes, Gestational/bl [Blood]
+ Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/et [Etiology]
+ Fasting/bl [Blood]
+ Female
+ Glucose Tolerance Test
+ Humans
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Pregnancy
+ Pregnancy Trimesters/bl [Blood]
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Seasons
+ Vitamin D Deficiency/bl [Blood]
+ *Vitamin D Deficiency/co [Complications]
+ Vitamin D Deficiency/di [Diagnosis]
+Keyword Heading
+ 25(OH)D
+ Fasting blood glucose
+ Gestational diabetes mellitus
+ Interaction
+ Seasonal variation
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & AIMS: To investigate the association of VitD with GDM, and examine the potential modifying effect of prepregnancy BMI in Chinese pregnant women.
+
+ METHODS: 3318 pregnant women underwent oral glucose tolerance test (OGTT) were selected from Zhoushan Pregnant Women Cohort. Plasma VitD levels were measured in the first (T1) and/or second trimester (T2). Multiple linear and logistic regression models were used for evaluating the association of VitD with GDM.
+
+ RESULTS: Prepregnancy BMI was positively associated with all three time-point glucose of OGTT. 25(OH)D level in T1 (beta = -0.003) and T2 (beta = -0.004), and its change from T1 to T2 (beta = -0.004) were significantly and inversely associated with fasting blood glucose (FBG) of OGTT, but not 1-h and 2-h postload blood glucose of OGTT, respectively. The negative associations of VitD and FBG were stronger among overweight/obese women. VitD deficiency (25(OH)D < 20 ng/ml) in T2 was associated with an increased risk of GDM with increased FBG, GDM subtype 1 (OR: 2.10) and subtype 3 (OR: 2.19). Moreover, prepregnancy BMI modified this effect on GDM subtype 1 (BMI < 24: OR = 1.42; BMI >= 24: OR = 9.61, P for interaction = 0.002). Lower VitD increment from T1 to T2 was associated with a higher risk for GDM among overweight/obese women. Additionally, GDM prevalence fluctuated with the season, i.e. lower in summer/fall and higher in winter/spring.
+
+ CONCLUSIONS: Maternal VitD deficiency was associated with a higher risk of GDM subtype with increased FBG, and the risk is much greater among overweight/obesity women. The lower the VitD increment during pregnancy, the greater the risk of GDM, especially in overweight/obesity women. Furthermore, seasonal variation of GDM may be exhibited as a critical confounder in the association of VitD and GDM. Copyright © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 21343-40-8 (25-Hydroxyvitamin D 2). P6YZ13C99Q (Calcifediol).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.clnu.2019.10.015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shao&issn=0261-5614&title=Clinical+Nutrition&atitle=The+interaction+between+prepregnancy+BMI+and+gestational+vitamin+D+deficiency+on+the+risk+of+gestational+diabetes+mellitus+subtypes+with+elevated+fasting+blood+glucose.&volume=39&issue=7&spage=2265&epage=2273&date=2020&doi=10.1016%2Fj.clnu.2019.10.015&pmid=31669001&sid=OVID:medline
+
+<1507>
+Unique Identifier
+ 31654550
+Title
+ Weighting approaches for a genetic risk score and an oxidative stress score for predicting the incidence of obesity.
+Source
+ Diabetes/Metabolism Research Reviews. 36(2):e3230, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Park S; Yoo HJ; Jee SH; Lee JH; Kim M
+Author NameID
+ Lee, Jong Ho; ORCID: https://orcid.org/0000-0002-2724-7295
+ Kim, Minjoo; ORCID: https://orcid.org/0000-0002-4261-9333
+Authors Full Name
+ Park, Seonmin; Yoo, Hye Jin; Jee, Sun Ha; Lee, Jong Ho; Kim, Minjoo.
+Institution
+ Park, Seonmin. Department of Science for Aging, Graduate School of Yonsei University, Seoul, Korea.
+ Yoo, Hye Jin. Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Korea.
+ Yoo, Hye Jin. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea.
+ Jee, Sun Ha. Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
+ Lee, Jong Ho. Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Korea.
+ Lee, Jong Ho. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea.
+ Kim, Minjoo. Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Korea.
+ Kim, Minjoo. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea.
+MeSH Subject Headings
+ Anthropometry
+ *Biomarkers/an [Analysis]
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ *Genetic Predisposition to Disease
+ Genome-Wide Association Study
+ Genotype
+ Humans
+ Incidence
+ Male
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ *Oxidative Stress
+ *Polymorphism, Single Nucleotide
+ Prognosis
+ ROC Curve
+ Republic of Korea/ep [Epidemiology]
+ Risk Factors
+Keyword Heading
+ Korean population
+ genetic risk score
+ obesity
+ oxidative stress score
+ prediction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: We aimed to predict the incidence of obesity in a Korean population using a genetic risk score (GRS) constructed with obesity-related single nucleotide polymorphisms (SNPs) along with an oxidative stress score (OSS).
+
+ METHODS: A total of 9460 Korean subjects and 356 974 SNPs were included. The GRS was constructed using three significant obesity-related SNP loci, and the OSS was calculated with three reliable oxidative stress biomarkers.
+
+ RESULTS: The GRS showed a more significant association with increased obesity (OR = 2.879) than did individual SNPs after adjusting for age and sex. Three oxidative stress biomarkers, including malondialdehyde, oxidized low-density lipoprotein, and 8-epi-prostaglandin F2alpha , showed significantly high levels in the obese group. The OSS, which was the sum of each oxidative stress biomarker score, showed a markedly high association with the incidence of obesity, with an OR of 3.213. Based on the results of the regression tests and a receiver-operating characteristic (ROC) curve analysis, we found that HOMA-IR, high-sensitivity C-reactive protein (hs-CRP), the GRS, and the OSS were the most relevant factors for the increased risk of obesity and were significantly associated with the incidence of obesity. The area under the ROC curve was improved when the GRS was added to the model (from 74.2% to 75.1%).
+
+ CONCLUSIONS: We first identified that subjects with an obesity GRS and a high OSS might have a higher risk of obesity. Our findings and weighting approaches were effective in predicting the incidence of obesity; furthermore, the GRS is a relevant factor that significantly predicts the risk of obesity. Copyright © 2019 John Wiley & Sons, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1002%2fdmrr.3230
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Park&issn=1520-7552&title=Diabetes%2FMetabolism+Research+Reviews&atitle=Weighting+approaches+for+a+genetic+risk+score+and+an+oxidative+stress+score+for+predicting+the+incidence+of+obesity.&volume=36&issue=2&spage=e3230&epage=&date=2020&doi=10.1002%2Fdmrr.3230&pmid=31654550&sid=OVID:medline
+
+<1508>
+Unique Identifier
+ 31629880
+Title
+ Six-week inspiratory resistance training ameliorates endurance performance but does not affect obesity-related metabolic biomarkers in obese adults: A randomized controlled trial.
+Source
+ Respiratory Physiology & Neurobiology. 273:103285, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kuo YC; Chang HL; Cheng CF; Mundel T; Liao YH
+Authors Full Name
+ Kuo, Yu-Chi; Chang, Hui-Lin; Cheng, Ching-Feng; Mundel, Toby; Liao, Yi-Hung.
+Institution
+ Kuo, Yu-Chi. Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
+ Chang, Hui-Lin. Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan; Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan.
+ Cheng, Ching-Feng. Department of Athletic Performance, National Taiwan Normal University, Taipei, Taiwan.
+ Mundel, Toby. School of Sport, Exercise and Nutrition, Massey University, Palmerston North, 4442, New Zealand.
+ Liao, Yi-Hung. Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. Electronic address: yihungliao.henry@gmail.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Body Composition/ph [Physiology]
+ Breathing Exercises/mt [Methods]
+ *Breathing Exercises
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Muscle Strength/ph [Physiology]
+ *Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ *Obesity/rh [Rehabilitation]
+ Outcome Assessment, Health Care
+ *Physical Endurance/ph [Physiology]
+ Respiratory Function Tests
+ *Respiratory Muscles/pp [Physiopathology]
+ Walk Test
+Keyword Heading
+ 6-minute walking capacity (6MWT)
+ Blood lipid profiles
+ Endurance capacity
+ Maximum inspiratory mouth pressure
+ Respiratory muscle training
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This investigation examined the effects of a six-week inspiratory resistance training (IRT) on metabolic health biomarkers, pulmonary function, and endurance in obese individuals. Twenty-eight obese adults (BMI>27kg/m2 Taiwan obesity criteria) were randomly assigned to either IRT (IRT; N=16) or sham control (PLA; N=12). The training parameters (twice/day; 3 days/week; 30 breaths/section; IRT: 55% PImax [maximal inspiratory pressure], PLA: 10% PImax) were identical. The endurance, pulmonary function, and blood lipid profiles were measured before/after intervention. After training, the PImax in IRT was greater than in PLA (+49.6%, p<.001), and the 6-minute walking test (6MWT) performance in IRT was greater than in PLA (+12.9%, p=0.001). However, there were no differences in pulmonary function (FVC, FEV1, or FEV1/FVC) and lipid profiles between groups. Our results demonstrate that a six-week progressively-programmed IRT was effective to improve endurance capacity and inspiratory muscle strength in obese individuals, whereas the IRT had no effects on pulmonary function, body composition, and blood lipid profiles. Copyright © 2019 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.resp.2019.103285
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kuo&issn=1569-9048&title=Respiratory+Physiology+%26+Neurobiology&atitle=Six-week+inspiratory+resistance+training+ameliorates+endurance+performance+but+does+not+affect+obesity-related+metabolic+biomarkers+in+obese+adults%3A+A+randomized+controlled+trial.&volume=273&issue=&spage=103285&epage=&date=2020&doi=10.1016%2Fj.resp.2019.103285&pmid=31629880&sid=OVID:medline
+
+<1509>
+Unique Identifier
+ 31616932
+Title
+ A Moderate-Fat Diet with One Avocado per Day Increases Plasma Antioxidants and Decreases the Oxidation of Small, Dense LDL in Adults with Overweight and Obesity: A Randomized Controlled Trial.
+Source
+ Journal of Nutrition. 150(2):276-284, 2020 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang L; Tao L; Hao L; Stanley TH; Huang KH; Lambert JD; Kris-Etherton PM
+Authors Full Name
+ Wang, Li; Tao, Ling; Hao, Lei; Stanley, Todd H; Huang, Kuan-Hsun; Lambert, Joshua D; Kris-Etherton, Penny M.
+Institution
+ Wang, Li. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.
+ Tao, Ling. Department of Food Science, Pennsylvania State University, University Park, PA, USA.
+ Hao, Lei. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.
+ Stanley, Todd H. Department of Food Science, Pennsylvania State University, University Park, PA, USA.
+ Huang, Kuan-Hsun. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.
+ Lambert, Joshua D. Department of Food Science, Pennsylvania State University, University Park, PA, USA.
+ Kris-Etherton, Penny M. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Antioxidants/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Cross-Over Studies
+ *Dietary Fats/ad [Administration & Dosage]
+ Female
+ Humans
+ Inflammation Mediators/me [Metabolism]
+ Lipoproteins, LDL/ch [Chemistry]
+ *Lipoproteins, LDL/me [Metabolism]
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+ *Overweight/me [Metabolism]
+ Oxidation-Reduction
+ Oxidative Stress
+ *Persea
+ RNA, Messenger/ge [Genetics]
+ Vitamins/me [Metabolism]
+ Young Adult
+Keyword Heading
+ CVD
+ LDL oxidation
+ MUFA
+ antioxidants
+ avocado
+ lipid
+ lipid transfer proteins
+ lipoprotein
+ small dense LDL
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Avocados are a nutrient-dense source of MUFAs and are rich in antioxidants. Avocados have an additional LDL cholesterol (LDL-C) lowering effect beyond that observed when their MUFAs are substituted for SFAs, especially on small, dense LDL (sdLDL) particles, which are susceptible to in vivo oxidation and associated with increased risk of cardiovascular disease (CVD).
+
+ OBJECTIVES: We investigated whether a healthy diet with 1 avocado daily decreased the following secondary outcomes: circulating oxidized LDL (oxLDL) and related oxidative stress markers.
+
+ METHODS: A randomized, crossover, controlled feeding trial was conducted with 45 men and women, aged 21-70 y, with overweight or obesity and elevated LDL-C (25th-90th percentile). Three cholesterol-lowering diets were provided (5 wk each) in random sequences: a lower-fat (LF) diet (24% calories from fat-7% SFAs, 11% MUFAs, 6% PUFAs) and 2 moderate-fat (MF) diets (34% calories from fat-6% SFAs, 17% MUFAs, 9% PUFAs): the avocado (AV) diet included 1 Hass avocado (~136 g) per day, and the MF diet used high oleic acid oils to match the fatty acid profile of 1 avocado. A general linear mixed model was used to analyze the treatment effects.
+
+ RESULTS: Compared with baseline, the AV diet significantly decreased circulating oxLDL (-7.0 U/L, -8.8%, P = 0.0004) and increased plasma lutein concentration (19.6 nmol/L, 68.7%, P < 0.0001), and both changes differed significantly from that after the MF and LF diets (P <= 0.05). The change in oxLDL caused by the AV diet was significantly correlated with the changes in the number of sdLDL particles (r = 0.32, P = 0.0002) but not large, buoyant LDL particles.
+
+ CONCLUSIONS: One avocado a day in a heart-healthy diet decreased oxLDL in adults with overweight and obesity, and the effect was associated with the reduction in sdLDL. This trial was registered at http://www.clinicaltrials.gov as NCT01235832. Copyright © American Society for Nutrition 2019.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Dietary Fats). 0 (Inflammation Mediators). 0 (Lipoproteins, LDL). 0 (RNA, Messenger). 0 (Vitamins).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1093%2fjn%2fnxz231
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0022-3166&title=Journal+of+Nutrition&atitle=A+Moderate-Fat+Diet+with+One+Avocado+per+Day+Increases+Plasma+Antioxidants+and+Decreases+the+Oxidation+of+Small%2C+Dense+LDL+in+Adults+with+Overweight+and+Obesity%3A+A+Randomized+Controlled+Trial.&volume=150&issue=2&spage=276&epage=284&date=2020&doi=10.1093%2Fjn%2Fnxz231&pmid=31616932&sid=OVID:medline
+
+<1510>
+Unique Identifier
+ 31608926
+Title
+ Efficacy, Safety, and Mechanistic Insights of Cotadutide, a Dual Receptor Glucagon-Like Peptide-1 and Glucagon Agonist.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(3), 2020 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Parker VER; Robertson D; Wang T; Hornigold DC; Petrone M; Cooper AT; Posch MG; Heise T; Plum-Moerschel L; Schlichthaar H; Klaus B; Ambery PD; Meier JJ; Hirshberg B
+Authors Full Name
+ Parker, Victoria E R; Robertson, Darren; Wang, Tao; Hornigold, David C; Petrone, Marcella; Cooper, Aidan T; Posch, Maximilian G; Heise, Tim; Plum-Moerschel, Leona; Schlichthaar, Heike; Klaus, Beate; Ambery, Philip D; Meier, Juris J; Hirshberg, Boaz.
+Institution
+ Parker, Victoria E R. AstraZeneca, Cambridge, England, UK.
+ Robertson, Darren. AstraZeneca, Cambridge, England, UK.
+ Wang, Tao. AstraZeneca, Gaithersburg, MD, USA.
+ Hornigold, David C. AstraZeneca, Cambridge, England, UK.
+ Petrone, Marcella. AstraZeneca, Cambridge, England, UK.
+ Cooper, Aidan T. AstraZeneca, Cambridge, England, UK.
+ Posch, Maximilian G. Charite Research Organisation GmbH, Berlin, Germany.
+ Heise, Tim. Profil, Neuss, Germany.
+ Plum-Moerschel, Leona. Profil, Mainz, Germany.
+ Schlichthaar, Heike. SMO.MD, Magdeburg, Germany.
+ Klaus, Beate. Nuvisan Pharma Services, Ulm, Germany.
+ Ambery, Philip D. AstraZeneca, Gothenburg, Sweden.
+ Meier, Juris J. St Josef-Hospital, Ruhr-University, Bochum, Germany.
+ Hirshberg, Boaz. AstraZeneca, Gaithersburg, MD, USA.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Double-Blind Method
+ Female
+ Follow-Up Studies
+ Glucagon/me [Metabolism]
+ Glucagon-Like Peptide 1/me [Metabolism]
+ *Glucagon-Like Peptide-1 Receptor/ag [Agonists]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ *Peptides/tu [Therapeutic Use]
+ Prognosis
+ *Receptors, Glucagon/ag [Agonists]
+Abstract
+ CONTEXT: Cotadutide is a dual receptor agonist with balanced glucagon-like peptide-1 and glucagon activity.
+
+ OBJECTIVE: To evaluate different doses of cotadutide and investigate underlying mechanisms for its glucose-lowering effects.
+
+ DESIGN/SETTING: Randomized, double-blind, phase 2a study conducted in 2 cohorts at 5 clinical trial sites.
+
+ PATIENTS: Participants were 65 adult overweight/obese patients with type 2 diabetes mellitus; 63 completed the study; 2 were withdrawn due to AEs.
+
+ INTERVENTION: Once-daily subcutaneous cotadutide or placebo for 49 days. Doses (50-300 microg) were uptitrated weekly (cohort 1) or biweekly (cohort 2).
+
+ MAIN OUTCOME MEASURES: Co-primary end points (cohort 1) were percentage changes from baseline to end of treatment in glucose (area under the curve from 0 to 4 hours [AUC0-4h]) post-mixed-meal tolerance test (MMTT) and weight. Exploratory measures included postprandial insulin and gastric emptying time (GET; cohort 2).
+
+ RESULTS: Patients received cotadutide (cohort 1, n = 26; cohort 2, n = 20) or placebo (cohort 1, n = 13; cohort 2, n = 6). Significant reductions were observed with cotadutide vs placebo in glucose AUC0-4h post MMTT (least squares mean [90% CI], -21.52% [-25.68, -17.37] vs 6.32% [0.45, 12.20]; P < 0.001) and body weight (-3.41% [-4.37, -2.44] vs -0.08% [-1.45, 1.28]; P = 0.002). A significant increase in insulin AUC0-4h post MMTT was observed with cotadutide (19.3 mU.h/L [5.9, 32.6]; P = 0.008) and GET was prolonged on day 43 with cotadutide vs placebo (t1/2: 117.2 minutes vs -42.9 minutes; P = 0.0392).
+
+ CONCLUSION: These results suggest that the glucose-lowering effects of cotadutide are mediated by enhanced insulin secretion and delayed gastric emptying.
+
+ TRIAL REGISTRATION: ClinicalTrials.gov, NCT03244800. Copyright © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glucagon-Like Peptide-1 Receptor). 0 (Peptides). 0 (Receptors, Glucagon). 89750-14-1 (Glucagon-Like Peptide 1). 9007-92-5 (Glucagon). QL6A9B13HW (cotadutide).
+Publication Type
+ Clinical Trial, Phase II. Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1210%2fclinem%2fdgz047
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Parker&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Efficacy%2C+Safety%2C+and+Mechanistic+Insights+of+Cotadutide%2C+a+Dual+Receptor+Glucagon-Like+Peptide-1+and+Glucagon+Agonist.&volume=105&issue=3&spage=803&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgz047&pmid=31608926&sid=OVID:medline
+
+<1511>
+Unique Identifier
+ 31597008
+Title
+ Lipocalin-2-The myth of its expression and function. [Review]
+Source
+ Basic & Clinical Pharmacology & Toxicology. 127(2):142-151, 2020 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li D; Yan Sun W; Fu B; Xu A; Wang Y
+Authors Full Name
+ Li, Dahui; Yan Sun, Wai; Fu, Bowen; Xu, Aimin; Wang, Yu.
+Institution
+ Li, Dahui. The State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
+ Yan Sun, Wai. The State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
+ Fu, Bowen. The State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
+ Xu, Aimin. The State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
+ Wang, Yu. The State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
+MeSH Subject Headings
+ *Acute Kidney Injury/bl [Blood]
+ Animals
+ Biomarkers/bl [Blood]
+ *Heart Failure/bl [Blood]
+ Humans
+ *Lipocalin-2/bl [Blood]
+ Lipocalin-2/ge [Genetics]
+ *Obesity/bl [Blood]
+ Oxidative Stress
+ Protein Processing, Post-Translational
+Keyword Heading
+ biomarker
+ heart failure
+ kidney injury
+ lipocalin-2
+ metabolic disease
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Lipocalin-2 is a functional biomarker for acute and chronic kidney diseases, heart failure and obesity-related medical complications. It is rapidly induced in epithelial cells under stress conditions, but constitutively produced from pre-adipocytes and mature adipocytes. Measuring the lipocalin-2 levels represents an effective approach for risk prediction, patient stratification and disease management. Nevertheless, due to ligand-binding, post-translational modification and protein-protein interaction, lipocalin-2 exists as multiple variants that elicit different pathophysiological functions. To characterize the specific structure-functional relationships of lipocalin-2 variants is critical for the development of biomarker assays with sufficient precision and reliability. Moreover, identifying the pathological forms of lipocalin-2 will provide new therapeutic targets and treatment approaches for obesity-related complications. Copyright © 2019 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipocalin-2).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2fbcpt.13332
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1742-7835&title=Basic+%26+Clinical+Pharmacology+%26+Toxicology&atitle=Lipocalin-2-The+myth+of+its+expression+and+function.&volume=127&issue=2&spage=142&epage=151&date=2020&doi=10.1111%2Fbcpt.13332&pmid=31597008&sid=OVID:medline
+
+<1512>
+Unique Identifier
+ 31591484
+Title
+ Early clinical markers of overweight/obesity onset and resolution by adolescence.
+Source
+ International Journal of Obesity. 44(1):82-93, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Juonala M; Lau T; Wake M; Grobler A; Kerr JA; Magnussen CG; Sabin MA; Burgner DP; Lycett K
+Author NameID
+ Juonala, Markus; ORCID: http://orcid.org/0000-0001-9498-364X
+ Kerr, Jessica A; ORCID: http://orcid.org/0000-0002-3150-4047
+Authors Full Name
+ Juonala, Markus; Lau, Ted; Wake, Melissa; Grobler, Anneke; Kerr, Jessica A; Magnussen, Costan G; Sabin, Matthew A; Burgner, David P; Lycett, Kate.
+Institution
+ Juonala, Markus. Department of Medicine, University of Turku, Turku, Finland. mataju@utu.fi.
+ Juonala, Markus. Division of Medicine, Turku University Hospital, Turku, Finland. mataju@utu.fi.
+ Juonala, Markus. Murdoch Children's Research Institute, Parkville, VIC, Australia. mataju@utu.fi.
+ Lau, Ted. Murdoch Children's Research Institute, Parkville, VIC, Australia.
+ Lau, Ted. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Wake, Melissa. Murdoch Children's Research Institute, Parkville, VIC, Australia.
+ Wake, Melissa. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Wake, Melissa. Department of Paediatrics and the Liggins Institute, The University of Auckland, Auckland, New Zealand.
+ Grobler, Anneke. Murdoch Children's Research Institute, Parkville, VIC, Australia.
+ Grobler, Anneke. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Kerr, Jessica A. Murdoch Children's Research Institute, Parkville, VIC, Australia.
+ Kerr, Jessica A. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Magnussen, Costan G. Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
+ Magnussen, Costan G. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
+ Sabin, Matthew A. Murdoch Children's Research Institute, Parkville, VIC, Australia.
+ Sabin, Matthew A. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Sabin, Matthew A. The Royal Children's Hospital, Parkville, VIC, Australia.
+ Burgner, David P. Murdoch Children's Research Institute, Parkville, VIC, Australia.
+ Burgner, David P. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+ Burgner, David P. The Royal Children's Hospital, Parkville, VIC, Australia.
+ Lycett, Kate. Murdoch Children's Research Institute, Parkville, VIC, Australia.
+ Lycett, Kate. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
+MeSH Subject Headings
+ Adolescent
+ Australia
+ Biomarkers
+ Body Mass Index
+ Body Size/ph [Physiology]
+ Child
+ Child, Preschool
+ Educational Status
+ Humans
+ Longitudinal Studies
+ Mothers/sn [Statistics & Numerical Data]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity
+ Overweight/di [Diagnosis]
+ Overweight/ep [Epidemiology]
+ *Overweight
+ Risk Assessment
+ Risk Factors
+Abstract
+ OBJECTIVES: We examined how combinations of clinical indicators at various ages predict overweight/obesity development, as well as resolution, by 10-11 and 14-15 years of age.
+
+ METHODS: Data were derived from Birth (N = 3469) and Kinder (N = 3276) cohorts of the Longitudinal Study of Australian Children, followed from ages 2-3 and 4-5 years, respectively. Every two years, 25 potential obesity-relevant clinical indicators were quantified. Overweight/obesity was defined using International Obesity Taskforce cutpoints at 10-11 years and 14-15 years.
+
+ RESULTS: In both cohorts, three factors predicted both development and resolution of overweight/obesity in multivariable models. Among normal weight children, increased odds of developing overweight/obesity were associated with higher child (odd ratio (OR) 1.67-3.35 across different study waves) and maternal (OR 1.05-1.09) BMI, and inversely with higher maternal education (OR 0.60-0.62, when assessed at age 2-7 years). Lower odds of resolving existing overweight/obesity were related with higher child (OR 0.51-0.79) and maternal (OR 0.89-0.95) BMI, and inversely with higher maternal education (OR 1.62-1.92, when assessed at age 2-5 years). The prevalence of overweight/obesity at the age of 14-15 years was 13% among children with none of these risk factors at age 6-7 years, compared with 71% among those with all 3 risk factors (P < 0.001).
+
+ CONCLUSIONS: From early childhood onwards, child and maternal BMI and maternal education predict overweight/obesity onset and resolution by adolescence. A simple risk score, easily available to child health clinicians, could help target treatment or prevention.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1038%2fs41366-019-0457-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Juonala&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Early+clinical+markers+of+overweight%2Fobesity+onset+and+resolution+by+adolescence.&volume=44&issue=1&spage=82&epage=93&date=2020&doi=10.1038%2Fs41366-019-0457-2&pmid=31591484&sid=OVID:medline
+
+<1513>
+Unique Identifier
+ 31587329
+Title
+ Targeting MDM2 for novel molecular therapy: Beyond oncology. [Review]
+Source
+ Medicinal Research Reviews. 40(3):856-880, 2020 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang W; Qin JJ; Rajaei M; Li X; Yu X; Hunt C; Zhang R
+Author NameID
+ Zhang, Ruiwen; ORCID: https://orcid.org/0000-0001-5323-0772
+Authors Full Name
+ Wang, Wei; Qin, Jiang-Jiang; Rajaei, Mehrdad; Li, Xin; Yu, Xiaoyi; Hunt, Courtney; Zhang, Ruiwen.
+Institution
+ Wang, Wei. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas.
+ Wang, Wei. Drug Discovery Institute, University of Houston, Houston, Texas.
+ Qin, Jiang-Jiang. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas.
+ Rajaei, Mehrdad. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas.
+ Li, Xin. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas.
+ Yu, Xiaoyi. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas.
+ Hunt, Courtney. Drug Discovery Institute, University of Houston, Houston, Texas.
+ Zhang, Ruiwen. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas.
+ Zhang, Ruiwen. Drug Discovery Institute, University of Houston, Houston, Texas.
+MeSH Subject Headings
+ Animals
+ Autoimmune Diseases/dt [Drug Therapy]
+ Biomarkers/me [Metabolism]
+ Dementia/dt [Drug Therapy]
+ Diabetes Mellitus/dt [Drug Therapy]
+ Glomerulonephritis/dt [Drug Therapy]
+ Heart Diseases/dt [Drug Therapy]
+ Humans
+ Inflammation/dt [Drug Therapy]
+ Kidney Diseases/dt [Drug Therapy]
+ Lupus Erythematosus, Systemic/dt [Drug Therapy]
+ Lupus Nephritis/dt [Drug Therapy]
+ Medical Oncology/mt [Methods]
+ Mice
+ *Molecular Targeted Therapy/mt [Methods]
+ Neoplasms/dt [Drug Therapy]
+ Neurodegenerative Diseases/dt [Drug Therapy]
+ Obesity/dt [Drug Therapy]
+ Prognosis
+ *Proto-Oncogene Proteins c-mdm2/ai [Antagonists & Inhibitors]
+ Rats
+ Sjogren's Syndrome/dt [Drug Therapy]
+ Tumor Suppressor Protein p53/me [Metabolism]
+Keyword Heading
+ MDM2
+ dementia
+ diabetes
+ inflammation
+ noncarcinogenic
+ p53
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The murine double minute 2 (MDM2) oncogene exerts major oncogenic activities in human cancers; it is not only the best-documented negative regulator of the p53 tumor suppressor, but also exerts p53-independent activities. There is an increasing interest in developing MDM2-based targeted therapies. Several classes of MDM2 inhibitors have been evaluated in preclinical models, with a few entering clinical trials, mainly for cancer therapy. However, noncarcinogenic roles for MDM2 have also been identified, demonstrating that MDM2 is involved in many chronic diseases and conditions such as inflammation and autoimmune diseases, dementia and neurodegenerative diseases, heart failure and cardiovascular diseases, nephropathy, diabetes, obesity, and sterility. MDM2 inhibitors have been shown to have promising therapeutic efficacy for treating inflammation and other nonmalignant diseases in preclinical evaluations. Therefore, targeting MDM2 may represent a promising approach for treating and preventing these nonmalignant diseases. In addition, a better understanding of how MDM2 works in nonmalignant diseases may provide new biomarkers for their diagnosis, prognostic prediction, and monitoring of therapeutic outcome. In this review article, we pay special attention to the recent findings related to the roles of MDM2 in the pathogenesis of several nonmalignant diseases, the therapeutic potential of its downregulation or inhibition, and its use as a biomarker. Copyright © 2019 Wiley Periodicals, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (TP53 protein, human). 0 (Tumor Suppressor Protein p53). EC 2-3-2-27 (MDM2 protein, human). EC 2-3-2-27 (Proto-Oncogene Proteins c-mdm2).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1002%2fmed.21637
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0198-6325&title=Medicinal+Research+Reviews&atitle=Targeting+MDM2+for+novel+molecular+therapy%3A+Beyond+oncology.&volume=40&issue=3&spage=856&epage=880&date=2020&doi=10.1002%2Fmed.21637&pmid=31587329&sid=OVID:medline
+
+<1514>
+Unique Identifier
+ 31581818
+Title
+ Effects of diet combined with Nordic walking or walking programme on weight loss and arterial stiffness in postmenopausal overweight and obese women: The Walking and Aging Verona pilot study.
+Source
+ European Journal of Preventive Cardiology. 27(19):2208-2211, 2020 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rossi AP; Muollo V; Fantin F; Masciocchi E; Urbani S; Taylor M; Caruso B; Milanese C; Capelli C; Schena F; Zamboni M
+Authors Full Name
+ Rossi, Andrea P; Muollo, Valentina; Fantin, Francesco; Masciocchi, Elena; Urbani, Silvia; Taylor, Miriam; Caruso, Beatrice; Milanese, Chiara; Capelli, Carlo; Schena, Federico; Zamboni, Mauro.
+Institution
+ Rossi, Andrea P. Department of Medicine, Division of Geriatrics, Healthy Aging Center, University of Verona, Italy.
+ Muollo, Valentina. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
+ Fantin, Francesco. Department of Medicine, Division of Geriatrics, Healthy Aging Center, University of Verona, Italy.
+ Masciocchi, Elena. Department of Medicine, Division of Geriatrics, Healthy Aging Center, University of Verona, Italy.
+ Urbani, Silvia. Department of Medicine, Division of Geriatrics, Healthy Aging Center, University of Verona, Italy.
+ Taylor, Miriam. Department of Medicine, Division of Geriatrics, Healthy Aging Center, University of Verona, Italy.
+ Caruso, Beatrice. Division of Clinical Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, Italy.
+ Milanese, Chiara. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
+ Capelli, Carlo. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
+ Schena, Federico. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
+ Zamboni, Mauro. Department of Medicine, Division of Geriatrics, Healthy Aging Center, University of Verona, Italy.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Diet, Reducing
+ Female
+ Humans
+ Middle Aged
+ *Obesity/pc [Prevention & Control]
+ *Overweight/pc [Prevention & Control]
+ Pilot Projects
+ *Postmenopause
+ *Vascular Stiffness/ph [Physiology]
+ *Walking/ph [Physiology]
+ *Weight Loss/ph [Physiology]
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1177%2f2047487319877712
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rossi&issn=2047-4873&title=European+Journal+of+Preventive+Cardiology&atitle=Effects+of+diet+combined+with+Nordic+walking+or+walking+programme+on+weight+loss+and+arterial+stiffness+in+postmenopausal+overweight+and+obese+women%3A+The+Walking+and+Aging+Verona+pilot+study.&volume=27&issue=19&spage=2208&epage=2211&date=2020&doi=10.1177%2F2047487319877712&pmid=31581818&sid=OVID:medline
+
+<1515>
+Unique Identifier
+ 31529060
+Title
+ Association between Body Mass Index and Stroke Risk Among Patients with Type 2 Diabetes.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 105(1), 2020 01 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shen Y; Shi L; Nauman E; Katzmarzyk PT; Price-Haywood EG; Bazzano AN; Nigam S; Hu G
+Authors Full Name
+ Shen, Yun; Shi, Lizheng; Nauman, Elizabeth; Katzmarzyk, Peter T; Price-Haywood, Eboni G; Bazzano, Alessandra N; Nigam, Somesh; Hu, Gang.
+Institution
+ Shen, Yun. Pennington Biomedical Research Center, Baton Rouge, LA, USA.
+ Shen, Yun. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
+ Shi, Lizheng. Department of Global Health Management and Policy, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA,USA.
+ Nauman, Elizabeth. Louisiana Public Health Institute, New Orleans, LA, USA.
+ Katzmarzyk, Peter T. Pennington Biomedical Research Center, Baton Rouge, LA, USA.
+ Price-Haywood, Eboni G. Ochsner Health System Center for Outcomes and Health Services Research, New Orleans, LA, USA.
+ Bazzano, Alessandra N. Department of Global Community Health and Behavioral Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
+ Nigam, Somesh. Blue Cross and Blue Shield of Louisiana, Baton Rouge, LA, USA.
+ Hu, Gang. Pennington Biomedical Research Center, Baton Rouge, LA, USA.
+MeSH Subject Headings
+ Aged
+ Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Prognosis
+ Retrospective Studies
+ Risk Factors
+ *Stroke/et [Etiology]
+ Stroke/me [Metabolism]
+ Stroke/pa [Pathology]
+Keyword Heading
+ body mass index
+ incident stroke
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Very few studies focused on the association between body mass index (BMI) and stroke risk among patients with diabetes.
+
+ OBJECTIVE: We aimed to investigate the association between BMI and stroke risk in patients with type 2 diabetes.
+
+ DESIGN: Demographic, anthropometric, laboratory, and medication information were extracted from the National Patient-Centered Clinical Research Network common data model.
+
+ PARTICIPANTS: We performed a retrospective cohort study of 67 086 patients with type 2 diabetes.
+
+ MAIN OUTCOME MEASURES: Incident stroke including both ischemic and hemorrhagic stroke were defined.
+
+ RESULTS: During a mean follow up of 3.74 years. 8918 incident stroke events occurred. Multivariable-adjusted hazard ratios across different categories of BMI at baseline (18.5-24.9 [reference group], 25.0-29.9, 30.0-34.9, 35.0-39.9, and >=40 kg/m2) were 1.00, 0.92, 0.85, 0.74, and 0.63 (Ptrend <0.001) for total stroke; 1.00, 0.93, 0.88, 0.77, and 0.65 (Ptrend <0.001) for ischemic stroke; and 1.00, 0.79, 0.50, 0.50, and 0.41 (Ptrend <0.001) for hemorrhagic stroke, respectively. When we used an updated mean value of BMI, the graded inverse association of body mass index with stroke risk did not change. This linear association was consistent among patients of different subgroups. Further sensitivity analysis excluding patients who were diagnosed stroke within 6 months after first diagnosis of type 2 diabetes or including non-smokers only also confirmed our findings.
+
+ CONCLUSION: The present study found an inverse association between BMI and the risk of total, ischemic, and hemorrhagic stroke among patients with type 2 diabetes. More clinical and molecular insights are still needed in explaining these findings. Copyright © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1210%2fclinem%2fdgz032
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shen&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Association+between+Body+Mass+Index+and+Stroke+Risk+Among+Patients+with+Type+2+Diabetes.&volume=105&issue=1&spage=96&epage=&date=2020&doi=10.1210%2Fclinem%2Fdgz032&pmid=31529060&sid=OVID:medline
+
+<1516>
+Unique Identifier
+ 31525129
+Title
+ Effects of Consuming Almonds on Insulin Sensitivity and Other Cardiometabolic Health Markers in Adults With Prediabetes.
+Source
+ Journal of the American College of Nutrition. 39(5):397-406, 2020 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Palacios OM; Maki KC; Xiao D; Wilcox ML; Dicklin MR; Kramer M; Trivedi R; Burton-Freeman B; Edirisinghe I
+Author NameID
+ Maki, Kevin C; ORCID: https://orcid.org/0000-0001-5147-5469
+Authors Full Name
+ Palacios, Orsolya M; Maki, Kevin C; Xiao, Di; Wilcox, Meredith L; Dicklin, Mary R; Kramer, Melvyn; Trivedi, Rupal; Burton-Freeman, Britt; Edirisinghe, Indika.
+Institution
+ Palacios, Orsolya M. Midwest Biomedical Research, Addison, Illinois, USA.
+ Maki, Kevin C. Midwest Biomedical Research, Addison, Illinois, USA.
+ Maki, Kevin C. MB Clinical Research, Boca Raton, Florida, USA.
+ Maki, Kevin C. Great Lakes Clinical Trials, Chicago, Illinois, USA.
+ Xiao, Di. Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
+ Wilcox, Meredith L. MB Clinical Research, Boca Raton, Florida, USA.
+ Dicklin, Mary R. Midwest Biomedical Research, Addison, Illinois, USA.
+ Kramer, Melvyn. MB Clinical Research, Boca Raton, Florida, USA.
+ Trivedi, Rupal. Great Lakes Clinical Trials, Chicago, Illinois, USA.
+ Burton-Freeman, Britt. Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
+ Edirisinghe, Indika. Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cardiometabolic Risk Factors
+ Cross-Over Studies
+ Dietary Carbohydrates/ad [Administration & Dosage]
+ Eating/ph [Physiology]
+ Female
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/dh [Diet Therapy]
+ Overweight/bl [Blood]
+ Overweight/co [Complications]
+ *Overweight/dh [Diet Therapy]
+ Prediabetic State/bl [Blood]
+ *Prediabetic State/dh [Diet Therapy]
+ Prediabetic State/et [Etiology]
+ *Prunus dulcis
+Keyword Heading
+ Almond
+ NCT03126981
+ carbohydrate metabolism
+ diabetes
+ dietary pattern
+ inflammation
+ insulin sensitivity
+ lipid metabolism
+ lipoprotein lipids
+ refined carbohydrate
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: This study was designed to assess the effects of replacing high-carbohydrate (CHO) foods with raw almonds on insulin sensitivity and cardiometabolic health markers in overweight or obese adults with prediabetes. Method: This randomized crossover study consisted of two 6-week dietary intervention periods, separated by a >= 4-week washout. Subjects incorporated 1.5 oz of raw almonds twice daily or isocaloric CHO-based foods into their diets, with instructions to maintain body weight. Dietary intakes as well as insulin sensitivity, CHO metabolism indices, lipoprotein lipids and particles, and inflammatory markers were assessed. Results: Thirty-three subjects (17 male, 16 female), mean age 48.3 +/- 2.2 years and body mass index 30.5 +/- 0.7 kg/m2, provided evaluable data. Compared to CHO, almonds resulted in significantly (p < 0.01) higher intakes of protein, fat (unsaturated fatty acids), fiber, and magnesium and significantly (p < 0.001) lower intakes of CHO and sugars. No differences were observed between diet conditions for changes from baseline in the insulin sensitivity index from a short intravenous glucose tolerance test or other indices of glucose homeostasis. No significant differences were observed in biomarkers of cardiovascular risk except that the CHO intervention led to a shift toward a higher concentration of cholesterol in small, dense low-density lipoprotein subfraction 3+4 (LDL3 + 4) particles (p = 0.024 vs almonds). Conclusions: Intake of 3.0 oz/d raw almonds, vs energy-matched CHO foods, improved the dietary nutrient profile, but did not significantly affect insulin sensitivity and most markers of cardiometabolic health in overweight and obese men and women with prediabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Carbohydrates).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1080%2f07315724.2019.1660929
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Palacios&issn=0731-5724&title=Journal+of+the+American+College+of+Nutrition&atitle=Effects+of+Consuming+Almonds+on+Insulin+Sensitivity+and+Other+Cardiometabolic+Health+Markers+in+Adults+With+Prediabetes.&volume=39&issue=5&spage=397&epage=406&date=2020&doi=10.1080%2F07315724.2019.1660929&pmid=31525129&sid=OVID:medline
+
+<1517>
+Unique Identifier
+ 31514105
+Title
+ Increased plasma osteopontin levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus.
+Source
+ Cytokine. 125:154837, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang C; He M; Peng J; Li S; Long M; Chen W; Liu D; Yang G; Zhang L
+Authors Full Name
+ Wang, Cong; He, Miao; Peng, Jiajia; Li, Shengbing; Long, Min; Chen, Wenwen; Liu, Dongfang; Yang, Gangyi; Zhang, Lili.
+Institution
+ Wang, Cong. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
+ He, Miao. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
+ Peng, Jiajia. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
+ Li, Shengbing. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
+ Long, Min. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
+ Chen, Wenwen. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
+ Liu, Dongfang. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
+ Yang, Gangyi. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
+ Zhang, Lili. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China. Electronic address: zhanglili.jl@foxmail.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ Blood Pressure
+ Body Mass Index
+ Correlation of Data
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Leukocytes/cy [Cytology]
+ Leukocytes/me [Metabolism]
+ Male
+ Middle Aged
+ Neutrophils/cy [Cytology]
+ Neutrophils/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Obesity/bl [Blood]
+ *Osteopontin/bl [Blood]
+ Overweight/co [Complications]
+ ROC Curve
+ Risk Factors
+ Triglycerides/bl [Blood]
+ Uric Acid/me [Metabolism]
+Keyword Heading
+ Nonalcoholic fatty liver disease
+ Osteopontin
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) commonly occurs in patients with type 2 diabetes mellitus (T2DM). Osteopontin (OPN) is a multifunctional protein with pleiotropic physiological functions. This study aimed to investigate the interrelation between circulating OPN and NAFLD in T2DM patients. Overall, 249 subjects were classified into 4 groups: 53 patients with NAFLD and T2DM; 57 with newly diagnosed T2DM; 59 with NAFLD; and 80 healthy age- and sex-matched controls. Serum OPN was measured by ELISA. The OPN distribution in the pooled data was divided into quartiles; significant trends across increasing quartiles were estimated by the Cochran-Armitage trend test. Compared with the controls, circulating OPN concentrations were significantly elevated in NAFLD patients and T2DM patients with or without NAFLD. Serum OPN levels were higher in the overweight/obese group than that in the lean group. Circulating OPN levels were positively correlated with CRP, age, BMI, SBP, DBP, HbA1c, UA, TGs, WBCs, neutrophils, FBG, and HOMA-IR and negatively correlated with ADP, albumin and HDL. Age, albumin, HbA1c, HDL and hsCRP were independently related to circulating OPN. The relative risks for NAFLD, T2DM and T2DM with NAFLD increased significantly along with increasing OPN quartiles based on the Cochran-Armitage trend test. OPN is an optimal predictor in the diagnosis of T2DM with NAFLD and T2DM and may contribute to the aggravation of the metabolic state. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Triglycerides). 106441-73-0 (Osteopontin). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.cyto.2019.154837
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1043-4666&title=Cytokine&atitle=Increased+plasma+osteopontin+levels+are+associated+with+nonalcoholic+fatty+liver+disease+in+patients+with+type+2+diabetes+mellitus.&volume=125&issue=&spage=154837&epage=&date=2020&doi=10.1016%2Fj.cyto.2019.154837&pmid=31514105&sid=OVID:medline
+
+<1518>
+Unique Identifier
+ 31504857
+Title
+ Prebiotics may reduce serum concentrations of C-reactive protein and ghrelin in overweight and obese adults: a systematic review and meta-analysis.
+Source
+ Nutrition Reviews. 78(3):235-248, 2020 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ da Silva Borges D; Fernandes R; Thives Mello A; da Silva Fontoura E; Soares Dos Santos AR; Santos de Moraes Trindade EB
+Authors Full Name
+ da Silva Borges, Dayanne; Fernandes, Ricardo; Thives Mello, Arthur; da Silva Fontoura, Ethiene; Soares Dos Santos, Adair Roberto; Santos de Moraes Trindade, Erasmo Benicio.
+Institution
+ da Silva Borges, Dayanne. D. da Silva Borges is with the Post-Graduate Program in Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ Fernandes, Ricardo. R. Fernandes is with the Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.
+ Thives Mello, Arthur. A. Thives Mello is with the Graduate Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ da Silva Fontoura, Ethiene. E. da Silva Fontoura is with the Post-Graduate Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ Soares Dos Santos, Adair Roberto. A.R. Soares dos Santos is with the Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+ Santos de Moraes Trindade, Erasmo Benicio. E.B.S. de Moraes Trindade is with the Department of Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
+MeSH Subject Headings
+ Adolescent
+ Adrenocorticotropic Hormone/bl [Blood]
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ *C-Reactive Protein/an [Analysis]
+ Gastrointestinal Microbiome
+ *Ghrelin/bl [Blood]
+ Humans
+ Hydrocortisone/bl [Blood]
+ Leptin/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ *Overweight/bl [Blood]
+ *Overweight/dh [Diet Therapy]
+ *Prebiotics
+ Synbiotics
+ Vitamin D/bl [Blood]
+ Young Adult
+Keyword Heading
+ C-reactive protein
+ ghrelin
+ obesity
+ prebiotics
+ synbiotics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Biochemical markers correlate positively with the development and severity of obesity, depression, and anxiety, and can be modulated by changes in intestinal microbiota composition.
+
+ OBJECTIVE: A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity.
+
+ DATA SOURCES: MEDLINE, Web of Science, Scopus, and CENTRAL databases were searched, along with the reference lists of included articles. Authors were contacted for unpublished data.
+
+ STUDY SELECTION: RCT in individuals with overweight or obesity, supplemented with prebiotics or synbiotics, assessing any of the outcomes of interest.
+
+ DATA EXTRACTION: Data were extracted independently by three researchers.
+
+ RESULTS: Thirteen studies were identified up to March 7, 2018. Regarding outcomes, 1 study assessed leptin, 4 studies assessed ghrelin, and 10 studies assessed CRP (C-reactive protein). Meta-analysis showed reduction in serum concentrations of ghrelin (-37.17 pg/mL; 95%CI = -69.62, -4.73; P = 0.025) and CRP (SMD [standardized mean difference] = -0.31; 95%CI = -0.58, -0.04; P = 0.027) after supplementation of inulin-type fructans.
+
+ CONCLUSIONS: Prebiotics may help regulate blood concentrations of ghrelin and CRP in overweight or obese individuals. Copyright © The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ghrelin). 0 (Leptin). 0 (Prebiotics). 1406-16-2 (Vitamin D). 9002-60-2 (Adrenocorticotropic Hormone). 9007-41-4 (C-Reactive Protein). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1093%2fnutrit%2fnuz045
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=da+Silva+Borges&issn=0029-6643&title=Nutrition+Reviews&atitle=Prebiotics+may+reduce+serum+concentrations+of+C-reactive+protein+and+ghrelin+in+overweight+and+obese+adults%3A+a+systematic+review+and+meta-analysis.&volume=78&issue=3&spage=235&epage=248&date=2020&doi=10.1093%2Fnutrit%2Fnuz045&pmid=31504857&sid=OVID:medline
+
+<1519>
+Unique Identifier
+ 31502758
+Title
+ Late-onset hypogonadism: metabolic impact. [Review]
+Source
+ Andrology. 8(6):1519-1529, 2020 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Grossmann M; Ng Tang Fui M; Cheung AS
+Author NameID
+ Grossmann, M; ORCID: https://orcid.org/0000-0001-8261-3457
+Authors Full Name
+ Grossmann, M; Ng Tang Fui, M; Cheung, A S.
+Institution
+ Grossmann, M. Department of Medicine Austin Health, University of Melbourne, Melbourne, Vic., Australia.
+ Grossmann, M. Department of Endocrinology, Austin Health, Melbourne, Vic., Australia.
+ Ng Tang Fui, M. Department of Medicine Austin Health, University of Melbourne, Melbourne, Vic., Australia.
+ Ng Tang Fui, M. Department of Endocrinology, Austin Health, Melbourne, Vic., Australia.
+ Cheung, A S. Department of Medicine Austin Health, University of Melbourne, Melbourne, Vic., Australia.
+ Cheung, A S. Department of Endocrinology, Austin Health, Melbourne, Vic., Australia.
+MeSH Subject Headings
+ Age of Onset
+ Animals
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Energy Metabolism
+ Hormone Replacement Therapy
+ Humans
+ Hypogonadism/di [Diagnosis]
+ Hypogonadism/dt [Drug Therapy]
+ Hypogonadism/ep [Epidemiology]
+ *Hypogonadism/me [Metabolism]
+ Insulin Resistance
+ Male
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/dt [Drug Therapy]
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome/me [Metabolism]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Testosterone/bl [Blood]
+ *Testosterone/df [Deficiency]
+ Testosterone/tu [Therapeutic Use]
+Keyword Heading
+ diabetes
+ late-onset hypogonadism
+ obesity
+ testosterone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity and dysglycemia (comprising insulin resistance, the metabolic syndrome and type 2 diabetes), that is diabesity, are associated with reduced circulating testosterone and, in some men, clinical features consistent with androgen deficiency.
+
+ OBJECTIVE: To review the metabolic impact of late-onset hypogonadism.
+
+ METHODS: Comprehensive literature search with emphasis on recent publications.
+
+ RESULTS: Obesity is one of the strongest modifiable risk factors for late-onset hypogonadism, and coexisting diabetes leads to further hypothalamic-pituitary-testicular axis suppression. The hypothalamic-pituitary-testicular axis suppression is functional and hence potentially reversible, and occurs predominantly at the level of the hypothalamus. While definitive mechanistic data are lacking, the evidence suggests that hypothalamic-pituitary-testicular axis suppression is mediated by dysregulation of pro-inflammatory cytokines leading to hypothalamic inflammation. Dysregulation of central leptin and insulin signaling may also contribute. In contrast, recent data challenge the paradigm that estradiol excess is a major contributor to hypothalamic-pituitary-testicular axis suppression. Instead, relative estradiol signaling deficiency may contribute to metabolic dysregulation in men with diabesity. While weight loss and optimization of comorbidities can reverse functional hypothalamic-pituitary-testicular axis suppression, testosterone treatment leads to metabolically favorable changes in body composition and to improvements in insulin resistance.
+
+ DISCUSSION: The relationship between diabesity and late-onset hypogonadism is bidirectional. Preliminary evidence suggests that, in carefully selected men, lifestyle measures and testosterone treatment may have additive effects.
+
+ CONCLUSIONS: While recent research has provided new insights into mechanistic and clinical aspects of diabesity-associated late-onset hypogonadism, more evidence from well-designed large trials is needed to guide the optimal clinical approach to such men. Copyright © 2019 American Society of Andrology and European Academy of Andrology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 3XMK78S47O (Testosterone).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1111%2fandr.12705
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Grossmann&issn=2047-2919&title=Andrology&atitle=Late-onset+hypogonadism%3A+metabolic+impact.&volume=8&issue=6&spage=1519&epage=1529&date=2020&doi=10.1111%2Fandr.12705&pmid=31502758&sid=OVID:medline
+
+<1520>
+Unique Identifier
+ 31491560
+Title
+ The weight of obesity in breast cancer progression and metastasis: Clinical and molecular perspectives. [Review]
+Source
+ Seminars in Cancer Biology. 60:274-284, 2020 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Barone I; Giordano C; Bonofiglio D; Ando S; Catalano S
+Authors Full Name
+ Barone, Ines; Giordano, Cinzia; Bonofiglio, Daniela; Ando, Sebastiano; Catalano, Stefania.
+Institution
+ Barone, Ines. Department of Pharmacy, Health and Nutritional Sciences, Via P Bucci, 87036, Rende, CS, Italy. Electronic address: ines.barone@unical.it.
+ Giordano, Cinzia. Department of Pharmacy, Health and Nutritional Sciences, Via P Bucci, 87036, Rende, CS, Italy; Centro Sanitario, University of Calabria, Via P Bucci, 87036, Rende, CS, Italy.
+ Bonofiglio, Daniela. Department of Pharmacy, Health and Nutritional Sciences, Via P Bucci, 87036, Rende, CS, Italy.
+ Ando, Sebastiano. Department of Pharmacy, Health and Nutritional Sciences, Via P Bucci, 87036, Rende, CS, Italy; Centro Sanitario, University of Calabria, Via P Bucci, 87036, Rende, CS, Italy.
+ Catalano, Stefania. Department of Pharmacy, Health and Nutritional Sciences, Via P Bucci, 87036, Rende, CS, Italy. Electronic address: stefcatalano@libero.it.
+MeSH Subject Headings
+ Biomarkers
+ *Breast Neoplasms/co [Complications]
+ Breast Neoplasms/ep [Epidemiology]
+ Breast Neoplasms/me [Metabolism]
+ *Breast Neoplasms/pa [Pathology]
+ Disease Progression
+ Epithelial-Mesenchymal Transition
+ Female
+ Humans
+ Leptin/me [Metabolism]
+ Neoplasm Metastasis
+ Neoplasm Staging
+ Neovascularization, Pathologic
+ *Obesity/co [Complications]
+Keyword Heading
+ Adipokines
+ Breast cancer
+ Leptin
+ Metastasis
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The escalating epidemic of overweight and obesity is currently recognized as one of the most significant health and economic concern worldwide. At the present time, over 1.9 billion adults and more than 600 million people can be, respectively, classified as overweight or obese, and numbers will continue to increase in the coming decades. This alarming scenario implies important clinical implications since excessive adiposity can progressively cause and/or exacerbate a wide spectrum of co-morbidities, including type 2 diabetes mellitus, hypertension, cardiovascular disease, and even certain types of cancer, including breast cancer. Indeed, pathological remodelling of white adipose tissue and increased levels of fat-specific cytokines (mainly leptin), as a consequence of the obesity condition, have been associated with several hallmarks of breast cancer, such as sustained proliferative signaling, cellular energetics, inflammation, angiogenesis, activating invasion and metastasis. Different preclinical and clinical data have provided evidence indicating that obesity may worsen the incidence, the severity, and the mortality of breast cancer. In the present review, we will discuss the epidemiological connection between obesity and breast cancer progression and metastasis and we will highlight the candidate players involved in this dangerous relationship. Since the major cause of death from cancer is due to widespread metastases, understanding these complex mechanisms will provide insights for establishing new therapeutic interventions to prevent/blunt the effects of obesity and thwart breast tumor progression and metastatic growth. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1016%2fj.semcancer.2019.09.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Barone&issn=1044-579X&title=Seminars+in+Cancer+Biology&atitle=The+weight+of+obesity+in+breast+cancer+progression+and+metastasis%3A+Clinical+and+molecular+perspectives.&volume=60&issue=&spage=274&epage=284&date=2020&doi=10.1016%2Fj.semcancer.2019.09.001&pmid=31491560&sid=OVID:medline
+
+<1521>
+Unique Identifier
+ 31462618
+Title
+ Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers.
+Source
+ Journal of Atherosclerosis & Thrombosis. 27(4):342-352, 2020 Apr 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sugiura T; Dohi Y; Takagi Y; Yoshikane N; Ito M; Suzuki K; Nagami T; Iwase M; Seo Y; Ohte N
+Authors Full Name
+ Sugiura, Tomonori; Dohi, Yasuaki; Takagi, Yasuyuki; Yoshikane, Naofumi; Ito, Mitsuhisa; Suzuki, Kenji; Nagami, Takashi; Iwase, Mitsunori; Seo, Yoshihiro; Ohte, Nobuyuki.
+Institution
+ Sugiura, Tomonori. Department of Cardiology, Nagoya City University Graduate School of Medical Sciences.
+ Sugiura, Tomonori. Health Support Center WELPO, Toyota Motor Corporation.
+ Dohi, Yasuaki. Department of Internal Medicine, Faculty of Rehabilitation Science, Nagoya Gakuin University.
+ Dohi, Yasuaki. Health Support Center WELPO, Toyota Motor Corporation.
+ Takagi, Yasuyuki. Health Support Center WELPO, Toyota Motor Corporation.
+ Takagi, Yasuyuki. Toyota Memorial Hospital.
+ Yoshikane, Naofumi. Health Support Center WELPO, Toyota Motor Corporation.
+ Ito, Mitsuhisa. Health Support Center WELPO, Toyota Motor Corporation.
+ Suzuki, Kenji. Health Support Center WELPO, Toyota Motor Corporation.
+ Nagami, Takashi. Health Support Center WELPO, Toyota Motor Corporation.
+ Iwase, Mitsunori. Toyota Memorial Hospital.
+ Seo, Yoshihiro. Department of Cardiology, Nagoya City University Graduate School of Medical Sciences.
+ Ohte, Nobuyuki. Department of Cardiology, Nagoya City University Graduate School of Medical Sciences.
+MeSH Subject Headings
+ *Atherosclerosis/ep [Epidemiology]
+ Atherosclerosis/et [Etiology]
+ Atherosclerosis/pa [Pathology]
+ *Biomarkers/an [Analysis]
+ Carotid Intima-Media Thickness
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ Japan/ep [Epidemiology]
+ Male
+ *Metabolic Syndrome/co [Complications]
+ Middle Aged
+ *Obesity/co [Complications]
+ Prognosis
+Keyword Heading
+ Atherosclerosis
+ Cardio-ankle vascular index
+ Carotid intima-media thickness
+ Metabolic syndrome
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Obesity is a social problem due to the prevalence of the Western lifestyle. In particular, visceral fat accumulation, which is a main component of metabolic syndrome, is closely associated with the progression of atherosclerosis. This study aimed to investigate the relationships of obesity-related indices and metabolic syndrome with subclinical atherosclerosis in middle-aged untreated workers.
+
+ METHODS: Employees undergoing their periodic health check-up but without previous cardiovascular events or cardiovascular medications were enrolled in this study (n=7,750). Body mass index (BMI), percent body fat, waist circumference, and visceral fat area were evaluated as obesity-related indices. Assessment of visceral fat area was performed by computed tomography (CT). Subclinical atherosclerosis was assessed by measuring arterial stiffness using cardio-ankle vascular index (CAVI) and by ultrasound examination of carotid intima-media thickness (IMT).
+
+ RESULTS: Obesity-related indices were significantly correlated with each other and were positively associated with carotid IMT but negatively associated with CAVI in multivariate regression analysis. In a logistic regression analysis including CAVI and carotid IMT simultaneously, CAVI was negatively associated, but carotid IMT was positively associated, with obesity defined by each obesity-related index. In contrast, both CAVI and carotid IMT were positively associated with the presence of metabolic syndrome based on visceral fat accumulation.
+
+ CONCLUSIONS: Obesity-related indices were negatively associated with CAVI and positively associated with carotid IMT in middle-aged untreated workers, while both CAVI and carotid IMT were worsened in the presence of metabolic syndrome.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.5551%2fjat.50633
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sugiura&issn=1340-3478&title=Journal+of+Atherosclerosis+%26+Thrombosis&atitle=Relationships+of+Obesity-Related+Indices+and+Metabolic+Syndrome+with+Subclinical+Atherosclerosis+in+Middle-Aged+Untreated+Japanese+Workers.&volume=27&issue=4&spage=342&epage=352&date=2020&doi=10.5551%2Fjat.50633&pmid=31462618&sid=OVID:medline
+
+<1522>
+Unique Identifier
+ 31442303
+Title
+ Randomized trial of weight loss in primary breast cancer: Impact on body composition, circulating biomarkers and tumor characteristics.
+Source
+ International Journal of Cancer. 146(10):2784-2796, 2020 05 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Demark-Wahnefried W; Rogers LQ; Gibson JT; Harada S; Fruge AD; Oster RA; Grizzle WE; Norian LA; Yang ES; Della Manna D; Jones LW; Azrad M; Krontiras H
+Author NameID
+ Demark-Wahnefried, Wendy; ORCID: https://orcid.org/0000-0001-5241-932X
+Authors Full Name
+ Demark-Wahnefried, Wendy; Rogers, Laura Q; Gibson, Justin T; Harada, Shuko; Fruge, Andrew D; Oster, Robert A; Grizzle, William E; Norian, Lyse A; Yang, Eddy S; Della Manna, Deborah; Jones, Lee W; Azrad, Maria; Krontiras, Helen.
+Institution
+ Demark-Wahnefried, Wendy. Department of Nutrition Sciences, University of Alabama at Birmingham (UAB) 1675 University Blvd, Birmingham, AL.
+ Demark-Wahnefried, Wendy. O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL.
+ Rogers, Laura Q. O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL.
+ Rogers, Laura Q. Division of Preventive Medicine, Birmingham, AL.
+ Gibson, Justin T. Department of Nutrition Sciences, University of Alabama at Birmingham (UAB) 1675 University Blvd, Birmingham, AL.
+ Harada, Shuko. O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL.
+ Harada, Shuko. Department of Pathology, Birmingham, AL.
+ Fruge, Andrew D. Auburn University, Auburn, AL.
+ Oster, Robert A. Department of Nutrition Sciences, University of Alabama at Birmingham (UAB) 1675 University Blvd, Birmingham, AL.
+ Oster, Robert A. Division of Preventive Medicine, Birmingham, AL.
+ Grizzle, William E. O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL.
+ Grizzle, William E. Department of Pathology, Birmingham, AL.
+ Norian, Lyse A. Department of Nutrition Sciences, University of Alabama at Birmingham (UAB) 1675 University Blvd, Birmingham, AL.
+ Norian, Lyse A. O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL.
+ Yang, Eddy S. O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL.
+ Yang, Eddy S. Department of Radiation Oncology, UAB, Birmingham, AL.
+ Della Manna, Deborah. Department of Radiation Oncology, UAB, Birmingham, AL.
+ Jones, Lee W. Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, NY.
+ Azrad, Maria. Department of Human Nutrition, Tuscaloosa, AL.
+ Krontiras, Helen. O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL.
+ Krontiras, Helen. Department of Surgery, UAB, Birmingham, AL.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Composition
+ *Breast Neoplasms/co [Complications]
+ *Caloric Restriction/mt [Methods]
+ Counseling/mt [Methods]
+ *Exercise Therapy/mt [Methods]
+ Female
+ Humans
+ *Obesity/co [Complications]
+ *Obesity/dh [Diet Therapy]
+ Overweight/co [Complications]
+ Overweight/dh [Diet Therapy]
+ Weight Loss/ph [Physiology]
+Keyword Heading
+ Ki67
+ breast cancer
+ clinical trial
+ diet
+ exercise
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity adversely impacts overall and cancer-specific survival among breast cancer patients. Preclinical studies demonstrate negative energy balance inhibits cancer progression; however, feasibility and effects in patients are unknown. A two-arm, single-blinded, randomized controlled weight-loss trial was undertaken presurgery among 32 overweight/obese, Stage 0-II breast cancer patients. The attention control arm (AC) received basic nutritional counseling and upper-body progressive resistance training whereas the weight loss intervention (WLI) arm received identical guidance, plus counseling on caloric restriction and aerobic exercise to promote 0.68-0.92 kg/week weight loss. Anthropometrics, body composition, blood and survey data were collected at baseline and presurgery ~30 days later. Tumor markers (e.g., Ki67) and gene expression were assessed on biopsy and surgical specimens; sera were analyzed for cytokines, growth and metabolic factors. Significant WLI vs. AC differences were seen in baseline-to-follow-up changes in weight (-3.62 vs. -0.52 kg), %body fat (-1.3 vs. 0%), moderate-to-vigorous physical activity (+224 vs. +115 min/week), caloric density (-0.3 vs. 0 kcal/g), serum leptin (-12.3 vs. -4.0 ng/dl) and upregulation of tumor PI3Kinase signaling and cell cycle-apoptosis related genes (CC-ARG; all p-values <0.05). Cytolytic CD56dim NK cell expression was positively associated with weight loss; CC-ARG increased with physical activity. Increased tumor (nuclear) TNFalpha and IL-1beta, CX3CL1 and CXCL1 gene expression was observed in the WLI. Tumor Ki67 did not differ between arms. Feasibility benchmarks included 80% accrual, 100% retention, no adverse effects and excellent adherence. Short-term weight loss interventions are feasible; however, mixed effects on tumor biology suggest unclear benefit to presurgical caloric restriction, but possible benefits of physical activity. Copyright © 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial, Phase II. Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1002%2fijc.32637
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Demark-Wahnefried&issn=0020-7136&title=International+Journal+of+Cancer&atitle=Randomized+trial+of+weight+loss+in+primary+breast+cancer%3A+Impact+on+body+composition%2C+circulating+biomarkers+and+tumor+characteristics.&volume=146&issue=10&spage=2784&epage=2796&date=2020&doi=10.1002%2Fijc.32637&pmid=31442303&sid=OVID:medline
+
+<1523>
+Unique Identifier
+ 31425383
+Title
+ Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia.
+Source
+ Medicine & Science in Sports & Exercise. 52(1):94-104, 2020 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Motiani KK; Collado MC; Eskelinen JJ; Virtanen KA; Loyttyniemi E; Salminen S; Nuutila P; Kalliokoski KK; Hannukainen JC
+Authors Full Name
+ Motiani, Kumail K; Collado, M Carmen; Eskelinen, Jari-Joonas; Virtanen, Kirsi A; Loyttyniemi, Eliisa; Salminen, Seppo; Nuutila, Pirjo; Kalliokoski, Kari K; Hannukainen, Jarna C.
+Institution
+ Motiani, Kumail K. Turku PET Centre, University of Turku, Turku, FINLAND.
+ Eskelinen, Jari-Joonas. Turku PET Centre, University of Turku, Turku, FINLAND.
+ Virtanen, Kirsi A. Turku PET Centre, Turku University Hospital, Turku, FINLAND.
+ Loyttyniemi, Eliisa. Department of Biostatistics, University of Turku, FINLAND.
+ Salminen, Seppo. Functional Food Forum, University of Turku, FINLAND.
+ Kalliokoski, Kari K. Turku PET Centre, University of Turku, Turku, FINLAND.
+ Hannukainen, Jarna C. Turku PET Centre, University of Turku, Turku, FINLAND.
+MeSH Subject Headings
+ Acute-Phase Proteins/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Carrier Proteins/me [Metabolism]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ *Endotoxemia/me [Metabolism]
+ *Endotoxemia/pc [Prevention & Control]
+ Female
+ *Gastrointestinal Microbiome
+ Humans
+ Inflammation/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ *Intestinal Mucosa/me [Metabolism]
+ Male
+ Membrane Glycoproteins/me [Metabolism]
+ Middle Aged
+ Obesity/me [Metabolism]
+ Oxygen Consumption/ph [Physiology]
+ *Physical Conditioning, Human/mt [Methods]
+ *Prediabetic State/me [Metabolism]
+ Tumor Necrosis Factor-alpha/me [Metabolism]
+Abstract
+ INTRODUCTION: Intestinal metabolism and microbiota profiles are impaired in obesity and insulin resistance. Moreover, dysbiotic gut microbiota has been suggested to promote systemic low-grade inflammation and insulin resistance through the release of endotoxins particularly lipopolysaccharides. We have previously shown that exercise training improves intestinal metabolism in healthy men. To understand whether changes in intestinal metabolism interact with gut microbiota and its release of inflammatory markers, we studied the effects of sprint interval (SIT) and moderate-intensity continuous training (MICT) on intestinal metabolism and microbiota in subjects with insulin resistance.
+
+ METHODS: Twenty-six, sedentary subjects (prediabetic, n = 9; type 2 diabetes, n = 17; age, 49 [SD, 4] yr; body mass index, 30.5 [SD, 3]) were randomized into SIT or MICT. Intestinal insulin-stimulated glucose uptake (GU) and fatty acid uptake (FAU) from circulation were measured using positron emission tomography. Gut microbiota composition was analyzed by 16S rRNA gene sequencing and serum inflammatory markers with multiplex assays and enzyme-linked immunoassay kit.
+
+ RESULTS: VO2peak improved only after SIT (P = 0.01). Both training modes reduced systematic and intestinal inflammatory markers (tumor necrosis factor-alpha, lipopolysaccharide binding protein) (time P < 0.05). Training modified microbiota profile by increasing Bacteroidetes phylum (time P = 0.03) and decreasing Firmicutes/Bacteroidetes ratio (time P = 0.04). Moreover, there was a decrease in Clostridium genus (time P = 0.04) and Blautia (time P = 0.051). Only MICT decreased jejunal FAU (P = 0.02). Training had no significant effect on intestinal GU. Colonic GU associated positively with Bacteroidetes and inversely with Firmicutes phylum, ratio Firmicutes/Bacteroidetes and Blautia genus.
+
+ CONCLUSIONS: Intestinal substrate uptake associates with gut microbiota composition and whole-body insulin sensitivity. Exercise training improves gut microbiota profiles and reduces endotoxemia.
+Registry Number/Name of Substance
+ 0 (Acute-Phase Proteins). 0 (Biomarkers). 0 (Carrier Proteins). 0 (Membrane Glycoproteins). 0 (TNF protein, human). 0 (Tumor Necrosis Factor-alpha). 0 (lipopolysaccharide-binding protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1249%2fMSS.0000000000002112
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Motiani&issn=0195-9131&title=Medicine+%26+Science+in+Sports+%26+Exercise&atitle=Exercise+Training+Modulates+Gut+Microbiota+Profile+and+Improves+Endotoxemia.&volume=52&issue=1&spage=94&epage=104&date=2020&doi=10.1249%2FMSS.0000000000002112&pmid=31425383&sid=OVID:medline
+
+<1524>
+Unique Identifier
+ 31420786
+Title
+ Association between the ADAMTS proteinases and obstructive sleep apnea.
+Source
+ Sleep & Breathing. 24(3):835-840, 2020 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sarioglu N; Erel F; Hismiogullari AA; Cevik C
+Author NameID
+ Sarioglu, Nurhan; ORCID: http://orcid.org/0000-0002-5180-9649
+Authors Full Name
+ Sarioglu, Nurhan; Erel, Fuat; Hismiogullari, A Adil; Cevik, Celalettin.
+Institution
+ Sarioglu, Nurhan. Medicine Faculty, Department of Pulmonary Medicine, Balikesir University, Balikesir, Turkey. nurhangencer@hotmail.com.
+ Erel, Fuat. Medicine Faculty, Department of Pulmonary Medicine, Balikesir University, Balikesir, Turkey.
+ Hismiogullari, A Adil. Medicine Faculty, Department of Biochemistry, Balikesir University, Balikesir, Turkey.
+ Cevik, Celalettin. Balikesir University, Health Science Faculty, Balikesir, Turkey.
+MeSH Subject Headings
+ *ADAMTS13 Protein/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Polysomnography
+ *Sleep Apnea, Obstructive/bl [Blood]
+ Sleep Apnea, Obstructive/co [Complications]
+ *Sleep Apnea, Obstructive/pp [Physiopathology]
+Keyword Heading
+ ADAMTS proteinases
+ Extracellular matrix
+ Sleep apnea
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: A disintegrin and metalloproteinase with thrombospondin type-1 motifs (ADAMTS) proteinases have important roles in degradation/repairing of extracellular matrix (ECM). They are thought to play a key role in pathogenesis of many diseases. We aimed to investigate the association between ADAMTS 2, 3, and 14 (procollagen) and obstructive sleep apnea (OSA).
+
+ METHODS: Eighty-six individuals who were suspected of OSA were included. All cases underwent polysomnography. Participants were divided into 3 groups according to apnea-hypopnea index (AHI): control (n = 22), mild-to-moderate OSA (n = 36), and severe OSA (n = 28). ADAMTS proteinases 2, 3, and 14 were analyzed in serum samples.
+
+ RESULTS: When compared with other groups, patients with severe OSA showed significantly higher body mass index (BMI) (p = 0.001), whereas they showed significantly lower ADAMTS 3 levels (p = 0.016). No difference was found between groups with respect to the levels ADAMTS 2 and 14. There was a negative relation between the levels of ADAMTS 3 and the severity of OSA (Kendall's tau = - 0.19, p = 0.021). The levels of ADAMTS 3 were also found to be positively correlated with minimum SpO2 (r = 0.31, p = 0.004) and negatively correlated with BMI, AHI, oxygen desaturation index (ODI), time duration with oxygen saturation < 90% (T90), and CRP (r = - 0.31 to - 0.49, p < 0.05). Multivariable regression analysis revealed that BMI (p = 0.013) and CRP levels (p = 0.005) were significantly associated with the levels of ADAMTS 3.
+
+ CONCLUSIONS: ADAMTS 3, one of the procollagen proteinases, was decreased in severe OSA. Lack of ADAMTS 3 proteinase may contribute to process of sleep apnea due to insufficient collagen syntheses.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4-24-87 (ADAMTS13 Protein). EC 3-4-24-87 (ADAMTS13 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs11325-019-01909-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sarioglu&issn=1520-9512&title=Sleep+%26+Breathing&atitle=Association+between+the+ADAMTS+proteinases+and+obstructive+sleep+apnea.&volume=24&issue=3&spage=835&epage=840&date=2020&doi=10.1007%2Fs11325-019-01909-0&pmid=31420786&sid=OVID:medline
+
+<1525>
+Unique Identifier
+ 31401679
+Title
+ TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity.
+Source
+ European Journal of Nutrition. 59(5):2249-2259, 2020 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hagen IV; Helland A; Bratlie M; Midttun O; McCann A; Sveier H; Rosenlund G; Mellgren G; Ueland PM; Gudbrandsen OA
+Author NameID
+ Gudbrandsen, Oddrun Anita; ORCID: http://orcid.org/0000-0001-5268-692X
+Authors Full Name
+ Hagen, Ingrid V; Helland, Anita; Bratlie, Marianne; Midttun, Oivind; McCann, Adrian; Sveier, Harald; Rosenlund, Grethe; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita.
+Institution
+ Hagen, Ingrid V. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, 5021, Bergen, Norway.
+ Helland, Anita. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, 5021, Bergen, Norway.
+ Bratlie, Marianne. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, 5021, Bergen, Norway.
+ Midttun, Oivind. Bevital AS, Jonas Lies veg 87, 5021, Bergen, Norway.
+ McCann, Adrian. Bevital AS, Jonas Lies veg 87, 5021, Bergen, Norway.
+ Sveier, Harald. Leroy Seafood Group ASA, PO Box 7600, 5020, Bergen, Norway.
+ Rosenlund, Grethe. Skretting Aquaculture Research Centre AS, PO Box 48, 4001, Stavanger, Norway.
+ Mellgren, Gunnar. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Haukeland University Hospital, 5021, Bergen, Norway.
+ Mellgren, Gunnar. Hormone Laboratory, Haukeland University Hospital, 5021, Bergen, Norway.
+ Ueland, Per Magne. Bevital AS, Jonas Lies veg 87, 5021, Bergen, Norway.
+ Gudbrandsen, Oddrun Anita. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, 5021, Bergen, Norway. oddrun.gudbrandsen@k1.uib.no.
+MeSH Subject Headings
+ Adult
+ Animals
+ Biomarkers
+ *Creatine
+ Humans
+ Methylamines
+ Methylhistidines
+ Obesity
+ Overweight
+ *Salmon
+Keyword Heading
+ 1-Methylhistidine
+ 3-Methylhistidine
+ Amino acids
+ Cod
+ Creatine
+ Salmon
+ TMAO
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: To identify biomarkers to assess participants' compliance in an intervention study with high intake of cod or salmon, compared to a fish-free diet.
+
+ METHODS: In this randomised clinical trial, 62 healthy overweight/obese participants consumed 750 g/week of either cod (N = 21) or salmon (N = 22) across 5 weekly dinners, or were instructed to continue their normal eating habits but avoid fish intake (Control group, N = 19) for 8 weeks.
+
+ RESULTS: After cod intake, serum concentrations of trimethylamine N-oxide (TMAO, p = 0.0043), creatine (p = 0.024) and 1-methylhistidine (1-MeHis, p = 0.014), and urine concentrations (relative to creatinine) of TMAO (p = 2.8 x 10-5), creatine (p = 8.3 x 10-4) and 1-MeHis (p = 0.016) were increased when compared to Control group. After salmon intake, serum concentrations of 1-MeHis (p = 2.0 x 10-6) and creatine (p = 6.1 x 10-4), and urine concentrations (relative to creatinine) of 1-MeHis (p = 4.2 x 10-6) and creatine (p = 4.0 x 10-5) were increased when compared to Control group. Serum and urine concentrations of TMAO were more increased following cod intake compared to salmon intake (p = 0.028 and 2.9 x 10-4, respectively), and serum and urine 1-MeHis concentrations were more increased after salmon intake compared to cod intake (p = 8.7 x 10-5 and 1.2 x 10-4, respectively). Cod and salmon intake did not affect serum and urine concentrations of 3-methylhistidine, and only marginally affected concentrations of free amino acids and amino acid metabolites.
+
+ CONCLUSION: TMAO measured in serum or urine is a potential biomarker of cod intake, and 1-MeHis measured in serum or urine is a potential biomarker of salmon intake.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Methylamines). 0 (Methylhistidines). 332-80-9 (1-methylhistidine). FLD0K1SJ1A (trimethyloxamine). MU72812GK0 (Creatine).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs00394-019-02076-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hagen&issn=1436-6207&title=European+Journal+of+Nutrition&atitle=TMAO%2C+creatine+and+1-methylhistidine+in+serum+and+urine+are+potential+biomarkers+of+cod+and+salmon+intake%3A+a+randomised+clinical+trial+in+adults+with+overweight+or+obesity.&volume=59&issue=5&spage=2249&epage=2259&date=2020&doi=10.1007%2Fs00394-019-02076-4&pmid=31401679&sid=OVID:medline
+
+<1526>
+Unique Identifier
+ 31399910
+Title
+ Effects of dietary whole grain, fruit, and vegetables on weight and inflammatory biomarkers in overweight and obese women.
+Source
+ Eating & Weight Disorders: EWD. 25(5):1243-1251, 2020 Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Arabzadegan N; Daneshzad E; Fatahi S; Moosavian SP; Surkan PJ; Azadbakht L
+Author NameID
+ Daneshzad, Elnaz; ORCID: http://orcid.org/0000-0003-1400-8532
+Authors Full Name
+ Arabzadegan, Niloufar; Daneshzad, Elnaz; Fatahi, Somayeh; Moosavian, Seyedeh Parisa; Surkan, Pamela J; Azadbakht, Leila.
+Institution
+ Arabzadegan, Niloufar. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Daneshzad, Elnaz. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Fatahi, Somayeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Moosavian, Seyedeh Parisa. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Surkan, Pamela J. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
+ Azadbakht, Leila. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. l-azadbakht@sina.tums.ac.ir.
+ Azadbakht, Leila. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. l-azadbakht@sina.tums.ac.ir.
+ Azadbakht, Leila. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. l-azadbakht@sina.tums.ac.ir.
+MeSH Subject Headings
+ Biomarkers
+ Diet
+ Female
+ Fruit
+ Humans
+ Obesity
+ Overweight
+ *Vegetables
+ *Whole Grains
+Keyword Heading
+ Diet
+ Inflammatory factors
+ Randomized clinical trial
+ Weight reduction
+ Whole grain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: The separate effects of whole grain (WG) and fruit and vegetable (F&V) diets on inflammatory biomarkers have not been assessed. Therefore, we evaluated these two high-fiber diets in relation to inflammation indices in obese and overweight women.
+
+ STUDY DESIGN: Parallel randomized clinical trial.
+
+ METHODS: In the present study, 75 women were recruited and randomly assigned to three diet groups: a whole grain diet (WG-D) group, F&V group, and a combined whole grain and F&V diet group (WGFV-D) for 10 weeks. As a "feeding trial" all participants were asked to visit the clinic daily and eat prescribed foods in the presence of a nutritionist. Anthropometric indices and biochemical biomarkers were measured at baseline and after 10 weeks of the trial.
+
+ RESULTS: Each of the three diet groups showed significant changes in serum biomarkers (CRP, TNF-alpha, IL-6, D-dimer, and serum fibrinogen) after following the diet for 10 weeks (P = 0.01). In adjusted models, significant changes were observed for CRP, TNF-alpha, IL-6, D-dimer, and serum fibrinogen (P = 0.01). In a model adjusted for malondialdehyde (MDA) level, a trend toward significance was observed (P = 0.05). Consumption of all three different diets for 10 weeks showed statistically significant change for all biomarkers (P < 0.05) the most notable changes in inflammatory indices were observed among participants following the WG diet.
+
+ CONCLUSIONS: Study results indicate that consumption of high-fiber diets, especially the WG diet, can help lower inflammatory levels and prevent subsequent adverse health consequences.
+
+ LEVEL OF EVIDENCE: Level I, randomized controlled trial.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2020
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med17&DO=10.1007%2fs40519-019-00757-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Arabzadegan&issn=1124-4909&title=Eating+%26+Weight+Disorders%3A+EWD&atitle=Effects+of+dietary+whole+grain%2C+fruit%2C+and+vegetables+on+weight+and+inflammatory+biomarkers+in+overweight+and+obese+women.&volume=25&issue=5&spage=1243&epage=1251&date=2020&doi=10.1007%2Fs40519-019-00757-x&pmid=31399910&sid=OVID:medline
+
+<1527>
+Unique Identifier
+ 31740368
+Title
+ Colchicine's effects on lipoprotein particle concentrations in adults with metabolic syndrome: A secondary analysis of a randomized controlled trial.
+Source
+ Journal of Clinical Lipidology. 13(6):1016-1022.e2, 2019 Nov - Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Demidowich AP; Wolska A; Wilson SR; Levine JA; Sorokin AV; Brady SM; Remaley AT; Yanovski JA
+Authors Full Name
+ Demidowich, Andrew P; Wolska, Anna; Wilson, Sierra R; Levine, Jordan A; Sorokin, Alexander V; Brady, Sheila M; Remaley, Alan T; Yanovski, Jack A.
+Institution
+ Demidowich, Andrew P. Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA; Johns Hopkins Community Physicians at Howard County General Hospital, Johns Hopkins Medicine, Columbia, MD, USA; Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: ademido1@jhmi.edu.
+ Wolska, Anna. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
+ Wilson, Sierra R. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
+ Levine, Jordan A. Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
+ Sorokin, Alexander V. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
+ Brady, Sheila M. Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
+ Remaley, Alan T. Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
+ Yanovski, Jack A. Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
+MeSH Subject Headings
+ Adult
+ Atherosclerosis/bl [Blood]
+ Atherosclerosis/dt [Drug Therapy]
+ Biomarkers/bl [Blood]
+ *Colchicine/tu [Therapeutic Use]
+ Double-Blind Method
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ Humans
+ *Lipoproteins/bl [Blood]
+ *Lipoproteins, LDL/bl [Blood]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/dt [Drug Therapy]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/dt [Drug Therapy]
+ Pilot Projects
+ Placebo Effect
+Keyword Heading
+ Atherosclerosis
+ Cardiovascular disease
+ Colchicine
+ Inflammation
+ Lipoprotein particles
+ Obesity
+ oxLDL
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Colchicine has received renewed interest for its potential beneficial effects in secondary prevention of cardiovascular disease. This was presumed to be primarily because of its anti-inflammatory effects; however, limited data exist regarding colchicine's impact on other cardiovascular risk factors.
+
+ OBJECTIVE: The aim of this study was to examine if colchicine's anti-inflammatory actions would lead to reduced circulating concentrations of oxidized low-density lipoprotein (oxLDL) in metabolically unhealthy individuals. We also examined if colchicine would improve concentrations of other atherogenic lipoprotein subfractions.
+
+ METHODS: This is a secondary analysis of a double-blind, randomized, placebo-controlled pilot study in which 40 adults with metabolic syndrome were randomized to colchicine 0.6 mg or placebo twice daily for 3 months. Blood samples were collected in the fasted state. OxLDL was measured using enzyme-linked immunosorbent assay. Nuclear magnetic resonance spectroscopy was used to measure other lipoprotein particle subfraction concentrations.
+
+ RESULTS: Compared with placebo, colchicine reduced markers of inflammation, including C-reactive protein, erythrocyte sedimentation rate, and GlycA (P < .01). Concentrations of oxLDL (P = .019) and small LDL (P = .022) appeared significantly increased in the colchicine arm. Colchicine had no significant effect on other lipoprotein subfractions or lipoprotein particle sizes (all P > .05).
+
+ CONCLUSION: Although colchicine may have benefit in secondary prevention of cardiovascular disease in at-risk individuals, we found no evidence that these effects are because of improvements in circulating atherogenic lipoprotein particle concentrations. Further studies are needed to confirm whether colchicine increases circulating oxLDL and small LDL levels in adults with metabolic syndrome. If true, additional research is warranted to elucidate the mechanisms underlying these associations. Copyright Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipoproteins). 0 (Lipoproteins, LDL). 0 (oxidized low density lipoprotein). SML2Y3J35T (Colchicine).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Intramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.jacl.2019.10.011
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Demidowich&issn=1933-2874&title=Journal+of+Clinical+Lipidology&atitle=Colchicine%27s+effects+on+lipoprotein+particle+concentrations+in+adults+with+metabolic+syndrome%3A+A+secondary+analysis+of+a+randomized+controlled+trial.&volume=13&issue=6&spage=1016&epage=1022.e2&date=2019&doi=10.1016%2Fj.jacl.2019.10.011&pmid=31740368&sid=OVID:medline
+
+<1528>
+Unique Identifier
+ 30825904
+Title
+ Risk of hypertension and abnormal biomarkers in the first year postpartum associated with hypertensive disorders of pregnancy among overweight and obese women.
+Source
+ Pregnancy Hypertension. 15:1-6, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hauspurg A; Countouris ME; Jeyabalan A; Hubel CA; Roberts JM; Schwarz EB; Catov JM
+Authors Full Name
+ Hauspurg, Alisse; Countouris, Malamo E; Jeyabalan, Arun; Hubel, Carl A; Roberts, James M; Schwarz, Eleanor B; Catov, Janet M.
+Institution
+ Hauspurg, Alisse. Department of Obstetrics, Gynecology and Reproductive Sciences, Univeristy of Pittsburgh School of Medicine, United States; Magee-Womens Research Institute, University of Pittsburgh, United States. Electronic address: janickia@upmc.edu.
+ Countouris, Malamo E. University of Pittsburgh Medical Center Heart and Vascular Institute, United States.
+ Jeyabalan, Arun. Department of Obstetrics, Gynecology and Reproductive Sciences, Univeristy of Pittsburgh School of Medicine, United States; Magee-Womens Research Institute, University of Pittsburgh, United States; Clinical and Translational Science Institute, University of Pittsburgh School of Medicine, United States.
+ Hubel, Carl A. Department of Obstetrics, Gynecology and Reproductive Sciences, Univeristy of Pittsburgh School of Medicine, United States; Magee-Womens Research Institute, University of Pittsburgh, United States.
+ Roberts, James M. Department of Obstetrics, Gynecology and Reproductive Sciences, Univeristy of Pittsburgh School of Medicine, United States; Magee-Womens Research Institute, University of Pittsburgh, United States; Clinical and Translational Science Institute, University of Pittsburgh School of Medicine, United States; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, United States.
+ Schwarz, Eleanor B. University of California Davis, United States.
+ Catov, Janet M. Department of Obstetrics, Gynecology and Reproductive Sciences, Univeristy of Pittsburgh School of Medicine, United States; Magee-Womens Research Institute, University of Pittsburgh, United States; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, United States.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ Cystatin C/bl [Blood]
+ Female
+ Follow-Up Studies
+ Humans
+ *Hypertension/ep [Epidemiology]
+ Hypertension/et [Etiology]
+ *Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ Postpartum Period
+ *Pre-Eclampsia/ep [Epidemiology]
+ Pre-Eclampsia/pp [Physiopathology]
+ Pregnancy
+ Prevalence
+ Prospective Studies
+ Risk Factors
+ Time Factors
+ Young Adult
+Keyword Heading
+ Cardiovascular disease
+ Chronic hypertension
+ Cystatin C
+ Gestational hypertension
+ HsCRP
+ Preeclampsia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Hypertension and obesity are common cardiometabolic risk factors in reproductive age women. The association of hypertensive disorders of pregnancy with later-life cardiovascular disease is well-established, however, it is unknown how obesity and hypertensive disorders of pregnancy converge to accelerate development of hypertension in the postpartum period. The aim of this study was to characterize rates of sustained hypertension at one year postpartum using the new American Heart Association/American College of Cardiology Guidelines among overweight and obese women with a normotensive pregnancy or hypertensive disorder of pregnancy.
+
+ STUDY DESIGN: 315 early pregnant women were enrolled prospectively and followed up to 12months after delivery (mean 7.0+/-1.8months). At a postpartum research visit, we measured blood pressure and collected blood samples to measure cystatin C and high sensitivity C-reactive protein.
+
+ RESULTS: A total of 254 women had a normotensive pregnancy, 39 had gestational hypertension (12.4%) and 22 had preeclampsia (7.0%). 91 women had hypertension at the postpartum study visit (28.9%). After adjustment for maternal age, BMI, lactation and time postpartum, preeclampsia was associated with an aOR 2.35 (95%CI 1.63-3.41) of development of sustained hypertension and an aOR 3.23 (95%CI 1.56-6.68) of hypertension with abnormal biomarkers compared to women with normotensive pregnancies.
+
+ CONCLUSIONS: We demonstrate a high prevalence of hypertension and abnormal biomarkers associated with hypertensive disorders of pregnancy among overweight and obese women. Our findings support the need for structured follow up and risk reduction in overweight and obese women with hypertensive disorders of pregnancy as early as the first year postpartum. Copyright © 2018 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cystatin C). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.preghy.2018.10.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hauspurg&issn=2210-7789&title=Pregnancy+Hypertension&atitle=Risk+of+hypertension+and+abnormal+biomarkers+in+the+first+year+postpartum+associated+with+hypertensive+disorders+of+pregnancy+among+overweight+and+obese+women.&volume=15&issue=&spage=1&epage=6&date=2019&doi=10.1016%2Fj.preghy.2018.10.009&pmid=30825904&sid=OVID:medline
+
+<1529>
+Unique Identifier
+ 29777230
+Title
+ Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes.
+Source
+ International Journal of Obesity. 43(2):285-296, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ O'Rourke RW; Johnson GS; Purnell JQ; Courcoulas AP; Dakin GF; Garcia L; Hinojosa M; Mitchell JE; Pomp A; Pories WJ; Spaniolas K; Flum DR; Wahed AS; Wolfe BM
+Authors Full Name
+ O'Rourke, Robert W; Johnson, Geoffrey S; Purnell, Jonathan Q; Courcoulas, Anita P; Dakin, Gregory F; Garcia, Luis; Hinojosa, Marcelo; Mitchell, James E; Pomp, Alfons; Pories, Walter J; Spaniolas, Konstantinos; Flum, David R; Wahed, Abdus S; Wolfe, Bruce M.
+Institution
+ O'Rourke, Robert W. Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA. rorourke@umich.edu.
+ O'Rourke, Robert W. Ann Arbor Veteran's Administration Hospital, Ann Arbor, MI, USA. rorourke@umich.edu.
+ Johnson, Geoffrey S. Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
+ Johnson, Geoffrey S. GlaxoSmithKline, Inc., Brentford, London, England.
+ Purnell, Jonathan Q. Department of Medicine, Oregon Health and Science University, Portland, OR, USA.
+ Courcoulas, Anita P. Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
+ Dakin, Gregory F. Weill Cornell University Medical Center, New York, NY, USA.
+ Garcia, Luis. University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.
+ Hinojosa, Marcelo. Department of Surgery, University of Washington, Seattle, WA, USA.
+ Mitchell, James E. Neuropsychiatric Research Institute, Fargo, ND, USA.
+ Pomp, Alfons. Weill Cornell University Medical Center, New York, NY, USA.
+ Pories, Walter J. Brody School of Medicine, East Carolina University, Greenville, NC, USA.
+ Spaniolas, Konstantinos. Brody School of Medicine, East Carolina University, Greenville, NC, USA.
+ Flum, David R. Department of Surgery, University of Washington, Seattle, WA, USA.
+ Wahed, Abdus S. Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
+ Wolfe, Bruce M. Department of Surgery, Oregon Health and Science University, Portland, OR, USA.
+MeSH Subject Headings
+ Adiposity/ph [Physiology]
+ Adult
+ *Bariatric Surgery/sn [Statistics & Numerical Data]
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ Female
+ Ghrelin/bl [Blood]
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/ep [Epidemiology]
+ *Inflammation
+ Leptin/bl [Blood]
+ Longitudinal Studies
+ Male
+ Metabolic Diseases/bl [Blood]
+ Metabolic Diseases/ep [Epidemiology]
+ *Metabolic Diseases
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/su [Surgery]
+ *Obesity
+ Treatment Outcome
+Abstract
+ BACKGROUND: The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic disease prevalence and outcomes after bariatric surgery are not well-defined.
+
+ METHODS: Associations between pre- and post-operative serum levels of four biomarkers (C-reactive protein (CRP), cystatin C (CC), leptin, and ghrelin) with baseline measures of adiposity and metabolic disease prevalence (asthma, diabetes, sleep apnea), and weight loss and metabolic disease remission after bariatric surgery were studied in the Longitudinal Assessment of Bariatric Surgery (LABS) cohort.
+
+ RESULTS: Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associated with increased baseline levels of leptin and CRP and decreased baseline levels of CC. Remission of diabetes and asthma was not associated with baseline levels of any biomarker. A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC. Bariatric surgery was associated with decreased post-operative CC, CRP, and leptin levels, and increased post-operative ghrelin levels.
+
+ CONCLUSION: This is the largest study to date of serum biomarkers of inflammation and adiposity in a bariatric surgery cohort. Biomarker levels correlate with metabolic disease prevalence prior to bariatric surgery, and with weight loss but not metabolic disease remission after surgery. Bariatric surgery regulates serum biomarker levels in a manner consistent with anti-inflammatory and compensatory orexigenic effects. These data contribute to our understanding of the mechanisms underlying the biologic effects of bariatric surgery.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ghrelin). 0 (Leptin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0088-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=O%27Rourke&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Serum+biomarkers+of+inflammation+and+adiposity+in+the+LABS+cohort%3A+associations+with+metabolic+disease+and+surgical+outcomes.&volume=43&issue=2&spage=285&epage=296&date=2019&doi=10.1038%2Fs41366-018-0088-z&pmid=29777230&sid=OVID:medline
+
+<1530>
+Unique Identifier
+ 31429114
+Title
+ Thirty-year risk of ischemic stroke in individuals with sickle cell trait and modification by chronic kidney disease: The atherosclerosis risk in communities (ARIC) study.
+Source
+ American Journal of Hematology. 94(12):1306-1313, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Caughey MC; Derebail VK; Key NS; Reiner AP; Gottesman RF; Kshirsagar AV; Heiss G
+Author NameID
+ Caughey, Melissa C; ORCID: https://orcid.org/0000-0001-8433-5147
+Authors Full Name
+ Caughey, Melissa C; Derebail, Vimal K; Key, Nigel S; Reiner, Alexander P; Gottesman, Rebecca F; Kshirsagar, Abhijit V; Heiss, Gerardo.
+Institution
+ Caughey, Melissa C. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
+ Derebail, Vimal K. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
+ Key, Nigel S. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
+ Reiner, Alexander P. Department of Epidemiology, University of Washington, Seattle, Washington.
+ Gottesman, Rebecca F. Department of Neurology, Johns Hopkins University, Baltimore, Maryland.
+ Kshirsagar, Abhijit V. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
+ Heiss, Gerardo. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Black or African American/ge [Genetics]
+ Atherosclerosis/bl [Blood]
+ *Atherosclerosis/ep [Epidemiology]
+ Biomarkers
+ Blood Proteins/an [Analysis]
+ Brain Ischemia/bl [Blood]
+ *Brain Ischemia/ep [Epidemiology]
+ Brain Ischemia/et [Etiology]
+ Brain Ischemia/ge [Genetics]
+ Comorbidity
+ Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Genetic Predisposition to Disease
+ Glomerular Filtration Rate
+ Hemoglobin C/ge [Genetics]
+ Hemoglobin, Sickle/ge [Genetics]
+ Hospitalization/sn [Statistics & Numerical Data]
+ Humans
+ Hyperlipidemias/ep [Epidemiology]
+ Hypertension/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Population Surveillance
+ Principal Component Analysis
+ Proportional Hazards Models
+ Prospective Studies
+ Renal Insufficiency, Chronic/bl [Blood]
+ *Renal Insufficiency, Chronic/ep [Epidemiology]
+ Risk Factors
+ Sickle Cell Trait/bl [Blood]
+ *Sickle Cell Trait/ep [Epidemiology]
+ Sickle Cell Trait/ge [Genetics]
+ Smoking/ep [Epidemiology]
+Abstract
+ Sickle cell trait (SCT) has been associated with hypercoagulability, chronic kidney disease (CKD), and ischemic stroke. Whether concomitant CKD modifies long-term ischemic stroke risk in individuals with SCT is uncertain. We analyzed data from 3602 genotyped black adults (female = 62%, mean baseline age = 54 years) who were followed for a median 26 years by the Atherosclerosis Risk in Communities Study. Ischemic stroke was verified by physician review. Associations between SCT and ischemic stroke were analyzed using repeat-events Cox regression, adjusted for potential confounders. SCT was identified in 236 (7%) participants, who more often had CKD at baseline than noncarriers (18% vs 13%, P = .02). Among those with CKD, elevated factor VII activity was more prevalent with SCT genotype (36% vs 22%; P = .05). From 1987-2017, 555 ischemic strokes occurred in 436 individuals. The overall hazard ratio of ischemic stroke associated with SCT was 1.31 (95% CI: 0.95-1.80) and was stronger in participants with concomitant CKD (HR = 2.18; 95% CI: 1.16-4.12) than those without CKD (HR = 1.09; 95% CI: 0.74-1.61); P for interaction = .04. The hazard ratio of composite ischemic stroke and/or death associated with SCT was 1.20 (95% CI: 1.01-1.42) overall, 1.44 (95% CI: 1.002-2.07) among those with CKD, and 1.15 (95% CI: 0.94-1.39) among those without CKD; P for interaction = .18. The long-term risk of ischemic stroke associated with SCT relative to noncarrier genotype appears to be modified by concomitant CKD. Copyright © 2019 Wiley Periodicals, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Proteins). 0 (Hemoglobin, Sickle). 9008-00-8 (Hemoglobin C).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fajh.25615
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Caughey&issn=0361-8609&title=American+Journal+of+Hematology&atitle=Thirty-year+risk+of+ischemic+stroke+in+individuals+with+sickle+cell+trait+and+modification+by+chronic+kidney+disease%3A+The+atherosclerosis+risk+in+communities+%28ARIC%29+study.&volume=94&issue=12&spage=1306&epage=1313&date=2019&doi=10.1002%2Fajh.25615&pmid=31429114&sid=OVID:medline
+
+<1531>
+Unique Identifier
+ 30137218
+Title
+ Effect of Intentional Weight Loss on Mortality Biomarkers in Older Adults With Obesity.
+Source
+ Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 74(8):1303-1309, 2019 07 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shaver LN; Beavers DP; Kiel J; Kritchevsky SB; Beavers KM
+Authors Full Name
+ Shaver, Lauren N; Beavers, Daniel P; Kiel, Jessica; Kritchevsky, Stephen B; Beavers, Kristen M.
+Institution
+ Shaver, Lauren N. Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.
+ Beavers, Daniel P. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
+ Kiel, Jessica. Department of Scientific and Clinical Affairs, Medifast, Inc., Baltimore, Maryland.
+ Kritchevsky, Stephen B. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School o f Medicine, Winston-Salem, North Carolina.
+ Beavers, Kristen M. Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.
+MeSH Subject Headings
+ Aged
+ *Biomarkers/an [Analysis]
+ Body Composition
+ *Caloric Restriction
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Mortality/td [Trends]
+ North Carolina
+ *Obesity/pc [Prevention & Control]
+ *Weight Loss
+Keyword Heading
+ Healthy Aging Index
+ Longevity
+ Multimorbidity
+ Successful Aging
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Observational research has identified several mortality biomarkers; however, their responsiveness to change is unknown. We tested whether the Healthy Aging Index (HAI) and other mortality biomarkers were responsive to intentional weight loss (WL), which is associated with lower mortality risk in recent meta-analyses.
+
+ METHODS: Older adults (70.3 +/- 3.7 years) with obesity were randomized into a 6-month WL (n = 47) or weight stability (WS: +/-5% baseline weight; n = 48) program. Baseline and 6-month HAI score (0-10) was calculated from component sum (each 0-2: systolic blood pressure, forced vital capacity [FVC], creatinine, fasting blood glucose [FBG], Montreal Cognitive Assessment), and gait speed, grip strength, Digit Symbol Substitution Test, FEV1, Interleukin-6, C-Reactive Protein, and Cystatin-C were assessed at baseline and 6 months.
+
+ RESULTS: Mean baseline HAI was 3.2 +/- 1.6. By 6 months, WL participants lost 8.87 (95% CI: -10.40, -7.34) kg, whereas WS participants remained weight stable. WL group reduced HAI score (WL: -0.75 [95% CI: -1.11, -0.39] vs WS: -0.22 [95% CI: -0.60, 0.15]; p = .04), and components changing the most were FBG (WL: -3.89 [95% CI: -7.78, 0.00] mg/dL vs WS: 1.45 [95% CI: -2.61, 5.50] mg/dL; p = .047) and FVC (WL: 0.11 [95% CI: -0.01, 0.23] L vs WS: -0.05 [95% CI: -0.17, 0.08] L; p = .06). Among other biomarkers, only Cystatin-C significantly changed (WL: -2.53 [95% CI: -4.38, -0.68] ng/mL vs WS: 0.07 [95% CI: -1.85, 1.98] ng/mL; p = .04). Combining treatment groups, 1 kg WL was associated with a 0.07 (95% CI: 0.03, 0.12) HAI reduction (p < .01).
+
+ CONCLUSION: Intentional WL via caloric restriction reduced HAI score by 0.53 points, largely attributable to metabolic and pulmonary improvements. Copyright © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fgerona%2fgly192
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shaver&issn=1079-5006&title=Journals+of+Gerontology+Series+A-Biological+Sciences+%26+Medical+Sciences&atitle=Effect+of+Intentional+Weight+Loss+on+Mortality+Biomarkers+in+Older+Adults+With+Obesity.&volume=74&issue=8&spage=1303&epage=1309&date=2019&doi=10.1093%2Fgerona%2Fgly192&pmid=30137218&sid=OVID:medline
+
+<1532>
+Unique Identifier
+ 31001636
+Title
+ Circulating obesity-driven biomarkers are associated with risk of clear cell renal cell carcinoma: a two-stage, case-control study.
+Source
+ Carcinogenesis. 40(10):1191-1197, 2019 10 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang Q; Tu H; Zhu M; Liang D; Ye Y; Chang DW; Long Y; Wu X
+Authors Full Name
+ Wang, Qinchuan; Tu, Huakang; Zhu, Meiling; Liang, Dong; Ye, Yuanqing; Chang, David W; Long, Yin; Wu, Xifeng.
+Institution
+ Wang, Qinchuan. Department of Surgical Oncology, Affiliated Sir Run Run Shaw Hospital and Department of Epidemiology and Health Statistics School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
+ Wang, Qinchuan. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+ Tu, Huakang. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+ Zhu, Meiling. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+ Zhu, Meiling. Department of Medical Oncology, Affiliated Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China.
+ Liang, Dong. Department of Pharmaceutical Sciences, Texas Southern University, Houston, TX, USA.
+ Ye, Yuanqing. Department of Surgical Oncology, Affiliated Sir Run Run Shaw Hospital and Department of Epidemiology and Health Statistics School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
+ Ye, Yuanqing. Center for Biostatistics, Bioinformatics and Big Data, The Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
+ Chang, David W. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+ Long, Yin. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+ Long, Yin. Center for Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China.
+ Wu, Xifeng. Department of Surgical Oncology, Affiliated Sir Run Run Shaw Hospital and Department of Epidemiology and Health Statistics School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
+ Wu, Xifeng. Center for Biostatistics, Bioinformatics and Big Data, The Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ Carcinoma, Renal Cell/bl [Blood]
+ Carcinoma, Renal Cell/et [Etiology]
+ *Carcinoma, Renal Cell/pa [Pathology]
+ Case-Control Studies
+ *Cytokines/bl [Blood]
+ Female
+ Follow-Up Studies
+ Humans
+ Insulin Resistance
+ *Interleukin-6/bl [Blood]
+ Kidney Neoplasms/bl [Blood]
+ Kidney Neoplasms/et [Etiology]
+ *Kidney Neoplasms/pa [Pathology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Prognosis
+ Retrospective Studies
+ *Tumor Necrosis Factor-alpha/bl [Blood]
+Abstract
+ Obesity is one of modifiable risk factors for clear cell renal cell cancer (ccRCC). We aim to identify the association between obesity-driven biomarkers and ccRCC risk. This is a retrospective, two-phase, case-control study involving 682 cases and 733 controls. Obesity-driven biomarkers [gastric inhibitory polypeptide (GIP), C-peptide, insulin, resistin, adipsin, peptide YY, pancreatic polypeptide, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), plasminogen activator inhibitor-1, monocyte chemoattractant protein 1, lipocalin2, leptin, adiponectin] were measured using the Milliplex method. Multivariate logistic regression was used to assess the associations between biomarkers and ccRCC risk. Results revealed that GIP, C-peptide, IL-6 and TNF-alpha levels were consistently distinct between cases and controls. These markers were significantly associated with ccRCC risk in both phases (except C-peptide). In the combined population, compared with individuals with low levels of the biomarkers, individuals with high level of GIP [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.40-0.67] had lower risk, whereas individuals with high levels of C-peptide (OR = 1.46, 95% CI: 1.15-1.87), IL-6 (OR = 2.20, 95% CI: 1.50-3.22), TNF-alpha (OR = 1.90, 95% CI: 1.49-2.43) had significantly higher risk. Stratified analysis showed consistent associations with ccRCC risk in most subgroups (P < 0.05). The risk score based on the IL-6, TNF-alpha and GIP was positively associated with ccRCC risk in a dose-response manner (P for trend = 2.18E-13). Data from The Cancer Genome Atlas indicate that insulin signaling, IL-6 signaling and TNF-alpha signaling were enhanced in tumors. Collectively, our study demonstrates the integrative effect of insulin resistance and inflammation in ccRCC development, which may elucidate the basis of association between obesity and carcinogenesis. Further confirmation in prospective cohort studies are warranted for clinical applications in prevention and precision medicine of ccRCC. Copyright © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (IL6 protein, human). 0 (Interleukin-6). 0 (TNF protein, human). 0 (Tumor Necrosis Factor-alpha). 0 (granulocyte inhibitory protein, human).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fcarcin%2fbgz074
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0143-3334&title=Carcinogenesis&atitle=Circulating+obesity-driven+biomarkers+are+associated+with+risk+of+clear+cell+renal+cell+carcinoma%3A+a+two-stage%2C+case-control+study.&volume=40&issue=10&spage=1191&epage=1197&date=2019&doi=10.1093%2Fcarcin%2Fbgz074&pmid=31001636&sid=OVID:medline
+
+<1533>
+Unique Identifier
+ 31933541
+Title
+ Abundance of Gut Microbiota, Concentration of Short-Chain Fatty Acids, and Inflammatory Markers Associated with Elevated Body Fat, Overweight, and Obesity in Female Adolescents.
+Source
+ Mediators of Inflammation. 2019:7346863, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Miranda VPN; Dos Santos Amorim PR; Bastos RR; de Faria ER; de Castro Moreira ME; do Carmo Castro Franceschini S; do Carmo Gouveia Peluzio M; de Luces Fortes Ferreira CL; Priore SE
+Author NameID
+ Miranda, Valter Paulo Neves; ORCID: https://orcid.org/0000-0002-2037-0573
+ do Carmo Gouveia Peluzio, Maria; ORCID: https://orcid.org/0000-0003-4665-7043
+Authors Full Name
+ Miranda, Valter Paulo Neves; Dos Santos Amorim, Paulo Roberto; Bastos, Ronaldo Rocha; de Faria, Eliane Rodrigues; de Castro Moreira, Maria Eliza; do Carmo Castro Franceschini, Sylvia; do Carmo Gouveia Peluzio, Maria; de Luces Fortes Ferreira, Celia Lucia; Priore, Silvia Eloiza.
+Institution
+ Miranda, Valter Paulo Neves. Department of Nutrition and Health and Department of Physical Education, Universidade Federal de Vicosa, Minas Gerais CEP 36570-900, Brazil.
+ Dos Santos Amorim, Paulo Roberto. Department of Physical Education, Universidade Federal de Vicosa, Vicosa, Minas Gerais CEP 36570-900, Brazil.
+ Bastos, Ronaldo Rocha. Department of Statistics-ICE, Universidade Federal de Juiz de Fora, Juiz de Fora MG, Brazil CEP 36036-330.
+ de Faria, Eliane Rodrigues. Department of Nutrition, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil CEP 36036-900.
+ de Castro Moreira, Maria Eliza. Department of Nutrition and Health, Universidade Federal de Vicosa, Minas Gerais CEP 36570-900, Brazil.
+ do Carmo Castro Franceschini, Sylvia. Department of Nutrition and Health, Universidade Federal de Vicosa, Minas Gerais CEP 36570-900, Brazil.
+ do Carmo Gouveia Peluzio, Maria. Department of Nutrition and Health, Universidade Federal de Vicosa, Minas Gerais CEP 36570-900, Brazil.
+ de Luces Fortes Ferreira, Celia Lucia. Department of Food Technology, Universidade Federal de Vicosa, Minas Gerais CEP 36570-900, Brazil.
+ Priore, Silvia Eloiza. Department of Nutrition and Health, Universidade Federal de Vicosa, Minas Gerais CEP 36570-900, Brazil.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ *Fatty Acids, Volatile/bl [Blood]
+ Female
+ *Gastrointestinal Microbiome/ph [Physiology]
+ Humans
+ *Obesity/bl [Blood]
+ *Obesity/mi [Microbiology]
+ *Overweight/bl [Blood]
+ *Overweight/mi [Microbiology]
+ Waist Circumference/ph [Physiology]
+ Waist-Height Ratio
+ Young Adult
+Abstract
+ BACKGROUND AND AIMS: Overweight is ever more prevalent in the pediatric population, and this cardiometabolic factor can be associated with inflammatory markers, gut microbiota composition, and short-chain fatty acid (SCFA) concentrations. The aim of this study is to evaluate to what extent the abundance of gut microbiota phyla, SCFA concentrations, and inflammatory markers are associated with elevated body fat percentage (BF%), overweight, and obesity in female adolescents.
+
+ METHODS: An experimental and comparative study was conducted with 96 girls 14 to 19 years old. They were divided into 3 groups: G1-eutrophic (EUT) and adequate BF%; G2-EUT and high BF%; and G3-overweight (OW) or obese (OB) and high BF%. Waist circumference (WC), waist to height ratio (WtHR), and neck circumference (NC) were analyzed as indicators of central visceral adiposity. The BF% was evaluated by DEXA equipment. A food frequency questionnaire was used to evaluate the main types of food consumed in a week. The abundance of the Firmicutes, Bacteroidetes, and Proteobacteria phyla was measured by real-time polymerase chain reaction (RT-qPCR), and the SFCA concentrations (acetic, butyric, and propionic) were determined by high-performance liquid chromatography (HPLC). The inflammatory markers leptin, tumor necrosis factor-alpha, interleukin-6, and high-sensitivity C-reactive protein (hs-CRP) were assessed.
+
+ RESULTS: Female adolescents in groups G2 and G3 had greater central visceral adiposity and leptin concentration than those in group G1. No association was found between gut microbiota phyla abundance and SFCA concentrations in any of the groups. WC and frequency of consumption of oily and fatty foods were associated with Firmicutes abundance and SFCA concentrations. Girls with high WC also had the greatest leptin (p < 0.001) and hs-CRP (p = 0.035) concentrations.
+
+ CONCLUSIONS: Inflammatory markers showed association with increased BMI and high BF% in female adolescents. The abundance of Firmicutes was associated with WC and NC, but not with BMI classification or BF%. Specifically, WC and the consumption of oils and fats showed correlation with SCFA concentrations. Different anthropometric indicators, such as NC and WC, should be incorporated into the clinical evaluation of the nutritional status of individuals in the adolescent population. Copyright © 2019 Valter Paulo Neves Miranda et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Volatile). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f7346863
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Miranda&issn=0962-9351&title=Mediators+of+Inflammation&atitle=Abundance+of+Gut+Microbiota%2C+Concentration+of+Short-Chain+Fatty+Acids%2C+and+Inflammatory+Markers+Associated+with+Elevated+Body+Fat%2C+Overweight%2C+and+Obesity+in+Female+Adolescents.&volume=2019&issue=&spage=7346863&epage=&date=2019&doi=10.1155%2F2019%2F7346863&pmid=31933541&sid=OVID:medline
+
+<1534>
+Unique Identifier
+ 31835615
+Title
+ Purine Catabolism Shows a Dampened Circadian Rhythmicity in a High-fat Diet-Induced Mouse Model of Obesity.
+Source
+ Molecules. 24(24), 2019 Dec 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sun R; Huang J; Yang N; He J; Yu X; Feng S; Xie Y; Wang G; Ye H; Aa J
+Authors Full Name
+ Sun, Runbin; Huang, Jingqiu; Yang, Na; He, Jun; Yu, Xiaoyi; Feng, Siqi; Xie, Yuan; Wang, Guangji; Ye, Hui; Aa, Jiye.
+Institution
+ Sun, Runbin. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ Huang, Jingqiu. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ Yang, Na. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ He, Jun. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ Yu, Xiaoyi. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ Feng, Siqi. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ Xie, Yuan. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ Wang, Guangji. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ Ye, Hui. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+ Aa, Jiye. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Circadian Rhythm
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ Disease Models, Animal
+ Metabolome
+ Metabolomics/mt [Methods]
+ Mice
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Purines/me [Metabolism]
+Keyword Heading
+ GC/MS
+ circadian rhythms
+ high-fat diet
+ metabolomics
+ obesity
+ purine catabolism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ High-calorie diet, circadian rhythms and metabolic features are intimately linked. However, the mediator(s) between nutritional status, circadian rhythms and metabolism remain largely unknown. This article aims to clarify the key metabolic pathways bridging nutritional status and circadian rhythms based on a combination of metabolomics and molecular biological techniques. A mouse model of high-fat diet-induced obesity was established and serum samples were collected in obese and normal mice at different zeitgeber times. Gas chromatography/mass spectrometry, multivariate/univariate data analyses and metabolic pathway analysis were used to reveal changes in metabolism. Metabolites involved in the metabolism of purines, carbohydrates, fatty acids and amino acids were markedly perturbed in accordance with circadian related variations, among which purine catabolism showed a typical oscillation. What's more, the rhythmicity of purine catabolism dampened in the high-fat diet group. The expressions of clock genes and metabolic enzymes in the liver were measured. The mRNA expression of Xanthine oxidase (Xor) was highly correlated with the rhythmicity of Clock, Rev-erbalpha and Bmal1, as well as the metabolites involved in purine catabolism. These data showed that a high-fat diet altered the circadian rhythm of metabolic pathways, especially purine catabolism. It had an obvious circadian oscillation and a high-fat diet dampened its circadian rhythmicity. It was suggested that circadian rhythmicity of purine catabolism is related to circadian oscillations of expression of Xor, Uox and corresponding clock genes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Purines). W60KTZ3IZY (purine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fmolecules24244524
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sun&issn=1420-3049&title=Molecules&atitle=Purine+Catabolism+Shows+a+Dampened+Circadian+Rhythmicity+in+a+High-fat+Diet-Induced+Mouse+Model+of+Obesity.&volume=24&issue=24&spage=4524&epage=&date=2019&doi=10.3390%2Fmolecules24244524&pmid=31835615&sid=OVID:medline
+
+<1535>
+Unique Identifier
+ 30663156
+Title
+ Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single-arm trial.
+Source
+ Journal of Human Nutrition & Dietetics. 32(4):468-479, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Buckland G; Travier N; Arribas L; Del Barco S; Pernas S; Zamora E; Bellet M; Cirauqui B; Margeli M; Munoz M; Tusquets I; Arcusa A; Javierre C; Moreno F; Valverde Y; Jansen E; Chajes V; Castro C; Agudo A
+Author NameID
+ Agudo, A; ORCID: https://orcid.org/0000-0001-9900-5677
+Authors Full Name
+ Buckland, G; Travier, N; Arribas, L; Del Barco, S; Pernas, S; Zamora, E; Bellet, M; Cirauqui, B; Margeli, M; Munoz, M; Tusquets, I; Arcusa, A; Javierre, C; Moreno, F; Valverde, Y; Jansen, E; Chajes, V; Castro, C; Agudo, A.
+Institution
+ Buckland, G. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Travier, N. Unit Breast Cancer Screening Unit, Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Arribas, L. Clinical Nutrition Unit, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
+ Del Barco, S. Department of Medical Oncology-ICO, Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain.
+ Pernas, S. Breast Cancer Unit, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
+ Zamora, E. Department of Breast Cancer Oncology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
+ Bellet, M. Department of Breast Cancer Oncology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
+ Cirauqui, B. Department of Medical Oncology-ICO, Hospital Germans Trias i Pujol, Badalona, Spain.
+ Margeli, M. Department of Medical Oncology-ICO, Hospital Germans Trias i Pujol, Badalona, Spain.
+ Munoz, M. Translational Genomics and Targeted Therapeutics, Institut d'Investigacions Biomediques Pi i Sunyer IDIBAPS, Barcelona, Spain.
+ Tusquets, I. Department of Medical Oncology, Hospital del Mar, Barcelona, Spain.
+ Arcusa, A. Department of Medical Oncology, Consorci Sanitari de Terrassa, Terrassa, Spain.
+ Javierre, C. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain.
+ Moreno, F. Breast Cancer Unit, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
+ Valverde, Y. Breast Cancer Unit, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
+ Jansen, E. Centre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
+ Chajes, V. Nutrition and Metabolism Department, International Agency for Research on Cancer, Lyon, France.
+ Castro, C. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Agudo, A. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Breast Neoplasms/bl [Blood]
+ Breast Neoplasms/co [Complications]
+ Cancer Survivors/px [Psychology]
+ *Carotenoids/bl [Blood]
+ *Diet/mt [Methods]
+ Diet/px [Psychology]
+ Energy Intake
+ *Erythrocyte Membrane/me [Metabolism]
+ Exercise
+ *Fatty Acids/an [Analysis]
+ Female
+ Humans
+ *Life Style
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Overweight/bl [Blood]
+ Overweight/co [Complications]
+ Overweight/th [Therapy]
+ Patient Compliance
+ Treatment Outcome
+ Young Adult
+Keyword Heading
+ breast cancer
+ carotenoids
+ diet
+ exercise
+ fatty acids
+ intervention
+ weight control
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The influence of nutrition on breast cancer prognosis is still inconclusive and therefore dietary interventions incorporating dietary biomarkers are needed to confirm compliance with dietary goals and clarify biological mechanisms. The present study assessed whether a lifestyle intervention in breast cancer survivors could affect dietary biomarkers of fruit and vegetables and fatty acids.
+
+ METHODS: In this phase II single-arm trial, 37 overweight/obese early stage breast cancer patients completed a 12-week diet and exercise intervention. The intervention involved 1-h weekly diet sessions delivered by a dietician and 75-min bi-weekly physical activity sessions of moderate-to-high intensity led by trained monitors. Before and after the intervention, three 24-h dietary recalls were carried out to calculate nutrient intakes and, in addition, blood samples were taken to measure plasma carotenoids, vitamin E and retinol concentrations and erythrocyte membrane fatty acid (EFA) composition. Wilcoxon signed rank tests were used to assess changes in dietary and biomarkers measurements over the intervention period.
+
+ RESULTS: After the intervention, there was a significant increase in the intake of dietary carotenoids (+15.1% compared to baseline) but not plasma carotenoids levels (+6.3%). Regarding the EFA levels, we observed a significant decrease in percentage of saturated fatty acids (-1.4%) and n-6 polyunsaturated fatty acids (-2.9%) and an increase in monounsaturated fatty acids (1.7%) and total and long-chain n-3 polyunsaturated fatty acids (by 13.1% and 13.7%, respectively). A favourable decrease in the ratio of long-chain n-6 to n-3 polyunsaturated fatty acids (-9.1%) was also observed.
+
+ CONCLUSIONS: After a short-term diet and exercise intervention in overweight/obese breast cancer survivors, we observed significant changes in dietary nutrients and fatty acid biomarkers, suggesting positive dietary changes that could be relevant for breast cancer prognosis. Copyright © 2019 The British Dietetic Association Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids). 36-88-4 (Carotenoids).
+Publication Type
+ Clinical Trial, Phase II. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fjhn.12621
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Buckland&issn=0952-3871&title=Journal+of+Human+Nutrition+%26+Dietetics&atitle=Changes+in+dietary+intake%2C+plasma+carotenoids+and+erythrocyte+membrane+fatty+acids+in+breast+cancer+survivors+after+a+lifestyle+intervention%3A+results+from+a+single-arm+trial.&volume=32&issue=4&spage=468&epage=479&date=2019&doi=10.1111%2Fjhn.12621&pmid=30663156&sid=OVID:medline
+
+<1536>
+Unique Identifier
+ 30622309
+Title
+ Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood.
+Source
+ International Journal of Obesity. 43(5):974-988, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lillycrop KA; Garratt ES; Titcombe P; Melton PE; Murray RJS; Barton SJ; Clarke-Harris R; Costello PM; Holbrook JD; Hopkins JC; Childs CE; Paras-Chavez C; Calder PC; Mori TA; Beilin L; Burdge GC; Gluckman PD; Inskip HM; Harvey NC; Hanson MA; Huang RC; Cooper C; Godfrey KM
+Author NameID
+ Melton, Phillip E; ORCID: http://orcid.org/0000-0003-4026-2964
+ Holbrook, Joanna D; ORCID: http://orcid.org/0000-0003-1791-6894
+ Inskip, Hazel M; ORCID: http://orcid.org/0000-0001-8897-1749
+ Godfrey, Keith M; ORCID: http://orcid.org/0000-0002-4643-0618
+Corporate Author
+ EpiGen Consortium
+Authors Full Name
+ Lillycrop, Karen A; Garratt, Emma S; Titcombe, Philip; Melton, Phillip E; Murray, Robert J S; Barton, Sheila J; Clarke-Harris, Rebecca; Costello, Paula M; Holbrook, Joanna D; Hopkins, James C; Childs, Caroline E; Paras-Chavez, Carolina; Calder, Philip C; Mori, Trevor A; Beilin, Lawrie; Burdge, Graham C; Gluckman, Peter D; Inskip, Hazel M; Harvey, Nicholas C; Hanson, Mark A; Huang, Rae-Chi; Cooper, Cyrus; Godfrey, Keith M.
+Institution
+ Lillycrop, Karen A. Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK. kal@soton.ac.uk.
+ Lillycrop, Karen A. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. kal@soton.ac.uk.
+ Garratt, Emma S. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
+ Garratt, Emma S. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Titcombe, Philip. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
+ Melton, Phillip E. Centre for Genetics of Health and Disease, University of Western Australia, Perth, Australia.
+ Melton, Phillip E. Faculty of Health Science, Curtin University, Perth, WA, Australia.
+ Murray, Robert J S. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Barton, Sheila J. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
+ Clarke-Harris, Rebecca. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Costello, Paula M. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Holbrook, Joanna D. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
+ Holbrook, Joanna D. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Hopkins, James C. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Childs, Caroline E. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Paras-Chavez, Carolina. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Calder, Philip C. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
+ Calder, Philip C. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Mori, Trevor A. School of Medicine, University of Western Australia, Perth, WA, Australia.
+ Beilin, Lawrie. School of Medicine, University of Western Australia, Perth, WA, Australia.
+ Burdge, Graham C. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Gluckman, Peter D. Liggins Institute, University of Auckland, Auckland, New Zealand.
+ Inskip, Hazel M. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
+ Inskip, Hazel M. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
+ Harvey, Nicholas C. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
+ Harvey, Nicholas C. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
+ Hanson, Mark A. Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
+ Huang, Rae-Chi. Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
+ Cooper, Cyrus. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
+ Cooper, Cyrus. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
+ Cooper, Cyrus. NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
+ Godfrey, Keith M. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
+ Godfrey, Keith M. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ *Adiposity/ge [Genetics]
+ Adolescent
+ Adult
+ Australia/ep [Epidemiology]
+ Biomarkers/me [Metabolism]
+ Child
+ Child, Preschool
+ Cohort Studies
+ DNA Methylation/ge [Genetics]
+ *DNA Methylation/ph [Physiology]
+ *Epigenesis, Genetic/ph [Physiology]
+ Female
+ Gene-Environment Interaction
+ Genetic Predisposition to Disease
+ Humans
+ Infant, Newborn
+ Male
+ Metabolic Diseases/ep [Epidemiology]
+ *Metabolic Diseases/ge [Genetics]
+ Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ Promoter Regions, Genetic/ge [Genetics]
+ *Serotonin Plasma Membrane Transport Proteins/me [Metabolism]
+Abstract
+ BACKGROUND: The early life environment may influence susceptibility to obesity and metabolic disease in later life through epigenetic processes. SLC6A4 is an important mediator of serotonin bioavailability, and has a key role in energy balance. We tested the hypothesis that methylation of the SLC6A4 gene predicts adiposity across the life course.
+
+ METHODS: DNA methylation at 5 CpGs within the SLC6A4 gene identified from a previous methyl binding domain array was measured by pyrosequencing. We measured DNA methylation in umbilical cord (UC) from children in the Southampton Women's Survey cohort (n = 680), in peripheral blood from adolescents in the Western Australian Pregnancy Cohort Study (n = 812), and in adipose tissue from lean and obese adults from the UK BIOCLAIMS cohort (n = 81). Real-time PCR was performed to assess whether there were corresponding alterations in gene expression in the adipose tissue.
+
+ RESULTS: Lower UC methylation of CpG5 was associated with higher total fat mass at 4 years (p = 0.031), total fat mass at 6-7 years (p = 0.0001) and % fat mass at 6-7 years (p = 0.004). Lower UC methylation of CpG5 was also associated with higher triceps skinfold thickness at birth (p = 0.013), 6 months (p = 0.038), 12 months (p = 0.062), 2 years (p = 0.0003), 3 years (p = 0.00004) and 6-7 years (p = 0.013). Higher maternal pregnancy weight gain (p = 0.046) and lower parity (p = 0.029) were both associated with lower SLC6A4 CpG5 methylation. In adolescents, lower methylation of CpG5 in peripheral blood was associated with greater concurrent measures of adiposity including BMI (p <= 0.001), waist circumference (p = 0.011), subcutaneous fat (p <= 0.001) and subscapular, abdominal and suprailiac skinfold thicknesses (p = 0.002, p = 0.008, p = 0.004, respectively). In adipose tissue, methylation of both SLC6A4 CpG5 (p = 0.019) and expression of SLC6A4 (p = 0.008) was lower in obese compared with lean adults.
+
+ CONCLUSIONS: These data suggest that altered methylation of CpG loci within SLC6A4 may provide a robust marker of adiposity across the life course.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (SLC6A4 protein, human). 0 (Serotonin Plasma Membrane Transport Proteins).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0254-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lillycrop&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Differential+SLC6A4+methylation%3A+a+predictive+epigenetic+marker+of+adiposity+from+birth+to+adulthood.&volume=43&issue=5&spage=974&epage=988&date=2019&doi=10.1038%2Fs41366-018-0254-3&pmid=30622309&sid=OVID:medline
+
+<1537>
+Unique Identifier
+ 31287846
+Title
+ Metabolic requirements of human pro-inflammatory B cells in aging and obesity.
+Source
+ PLoS ONE [Electronic Resource]. 14(7):e0219545, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Frasca D; Diaz A; Romero M; Thaller S; Blomberg BB
+Author NameID
+ Frasca, Daniela; ORCID: https://orcid.org/0000-0002-9816-6679
+Authors Full Name
+ Frasca, Daniela; Diaz, Alain; Romero, Maria; Thaller, Seth; Blomberg, Bonnie B.
+Institution
+ Frasca, Daniela. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Diaz, Alain. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Romero, Maria. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Thaller, Seth. Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Blomberg, Bonnie B. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+ Blomberg, Bonnie B. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States of America.
+MeSH Subject Headings
+ AMP-Activated Protein Kinases/me [Metabolism]
+ Adult
+ Aged
+ Aging/ge [Genetics]
+ *Aging/me [Metabolism]
+ Autoimmunity
+ *B-Lymphocyte Subsets/me [Metabolism]
+ *Biomarkers
+ Energy Metabolism/ge [Genetics]
+ *Energy Metabolism
+ Gene Expression Regulation
+ Humans
+ Middle Aged
+ Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ Oxidative Stress
+ RNA, Messenger
+ Reactive Oxygen Species
+ T-Box Domain Proteins/ge [Genetics]
+ T-Box Domain Proteins/me [Metabolism]
+ Young Adult
+Abstract
+ The subset of pro-inflammatory B cells, called late memory, tissue-like or double negative (DN), accumulates in the blood of elderly individuals. Here we show that DN B cells do not proliferate and do not make antibodies to influenza antigens, but they secrete antibodies with autoimmune reactivity, in agreement with their membrane phenotype (CD95+CD21-CD11c+) and their spontaneous expression of the transcription factor T-bet. These cells also increase in the blood of individuals with obesity and autoimmune diseases, but causative mechanisms and signaling pathways involved are known only in part. In the present paper we compare frequencies and metabolic requirements of these cells in the blood of healthy individuals of different ages and in the blood and the subcutaneous adipose tissue (SAT) of individuals with obesity. Results show that DN B cells from young individuals have minimal metabolic requirements, DN B cells from elderly and obese individuals utilize higher amounts of glucose to perform autoimmune antibody production and enroll in aerobic glycolysis to support their function. DN B cells from the SAT have the highest metabolic requirements as they activate oxidative phosphorylation, aerobic glycolysis and fatty acid oxidation. DN B cells from the SAT also show the highest levels of ROS and the highest levels of phosphorylated AMPK (5'-AMP activated kinase) and Sestrin 1, both able to mitigate stress and cell death. This metabolic advantage drives DN B cell survival and function (secretion of autoimmune antibodies).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Messenger). 0 (Reactive Oxygen Species). 0 (T-Box Domain Proteins). 0 (T-box transcription factor TBX21). EC 2-7-11-31 (AMP-Activated Protein Kinases).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0219545
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Frasca&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Metabolic+requirements+of+human+pro-inflammatory+B+cells+in+aging+and+obesity.&volume=14&issue=7&spage=e0219545&epage=&date=2019&doi=10.1371%2Fjournal.pone.0219545&pmid=31287846&sid=OVID:medline
+
+<1538>
+Unique Identifier
+ 30904846
+Title
+ Childhood maltreatment and biomarkers for cardiometabolic disease in mid-adulthood in a prospective British birth cohort: associations and potential explanations.
+Source
+ BMJ Open. 9(3):e024079, 2019 03 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li L; Pinto Pereira SM; Power C
+Author NameID
+ Li, Leah; ORCID: https://orcid.org/0000-0002-3603-6457
+Authors Full Name
+ Li, Leah; Pinto Pereira, Snehal M; Power, Christine.
+Institution
+ Li, Leah. Population, Policy and Practice Programme, University College London Great Ormond Street Institute of Child Health, London, UK.
+ Pinto Pereira, Snehal M. Population, Policy and Practice Programme, University College London Great Ormond Street Institute of Child Health, London, UK.
+ Power, Christine. Population, Policy and Practice Programme, University College London Great Ormond Street Institute of Child Health, London, UK.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adiposity
+ Adolescent
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ Child
+ *Child Abuse
+ Female
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Linear Models
+ Lipids/bl [Blood]
+ Logistic Models
+ Male
+ *Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/et [Etiology]
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Obesity/et [Etiology]
+ Odds Ratio
+ Prospective Studies
+ Public Health Surveillance
+ United Kingdom/ep [Epidemiology]
+ *Waist Circumference
+Keyword Heading
+ cardiometabolic biomarkers
+ child abuse
+ child maltreatment
+ child neglect
+ cohort study
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Research on associations between childhood maltreatment and adult cardiometabolic disease risk is sparse. We aimed to investigate associations between different forms of child maltreatment and mid-adult cardiometabolic markers and whether potential intermediaries could account for the associations observed.
+
+ SETTING: 1958 British birth cohort.
+
+ PARTICIPANTS: Approximately 9000 cohort members with data on cardiometabolic markers.
+
+ OUTCOMES: Adult (45y) cardiometabolic markers (blood pressure, lipids and glycated haemoglobin [HbA1c]).
+
+ RESULTS: Seventeen per cent of participants were identified as neglected; 6.1%, 1.6% and 10.0% were identified as experiencing physical, sexual and psychological abuse, respectively. Childhood neglect and physical abuse were associated with high body mass index (BMI) and large waist circumference when adjusting for early-life covariates. For neglect, the adjusted odds ratio (AOR) was 1.16 (95% CI: 1.02 to 1.32) and 1.15 (1.02 to 1.30) for general and central obesity, respectively, and for physical abuse, the respective AOR was 1.36 (1.13 to 1.64) and 1.38 (1.16 to 1.65). Neglect was also associated with raised triglycerides by 3.9 (0.3 to 7.5)% and HbA1c by 1.2 (0.4 to 2.0)%, and among females, lower high-density lipoprotein cholesterol (HDL-c) by 0.05 (0.01 to 0.08)mmol/L after adjustment. For physical abuse, the AOR was 1.25 (1.00 to 1.56) for high low-density lipoprotein cholesterol, HbA1c was raised by 2.5 (0.7 to 4.3)% (in males) and HDL-c was lower by 0.06 (0.01 to 0.12)mmol/L (in females). Associations for sexual abuse were similar to those for physical abuse but 95% CIs were wide. For psychological abuse, the AOR for elevated triglycerides was 1.21 (1.02 to 1.44) and HDL-c was lower by 0.04 (0.01 to 0.07)mmol/L. Maltreatments were not associated with raised blood pressure. In analyses of potential intermediary factors, several associations attenuated after adjustment for adult lifestyles (mainly smoking and alcohol consumption rather than physical activity) and child-to-adult BMI.
+
+ CONCLUSIONS: Childhood maltreatments, particularly neglect and physical abuse, were associated with greater adiposity and poorer lipid and HbA1c profiles decades later in adulthood. Associations were modest but independent of early-life factors linked to these outcomes. Findings implicate adult lifestyles as an important intermediary between child maltreatment and outcomes. Copyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1136%2fbmjopen-2018-024079
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=2044-6055&title=BMJ+Open&atitle=Childhood+maltreatment+and+biomarkers+for+cardiometabolic+disease+in+mid-adulthood+in+a+prospective+British+birth+cohort%3A+associations+and+potential+explanations.&volume=9&issue=3&spage=e024079&epage=&date=2019&doi=10.1136%2Fbmjopen-2018-024079&pmid=30904846&sid=OVID:medline
+
+<1539>
+Unique Identifier
+ 30659075
+Title
+ Clusterin Impairs Hepatic Insulin Sensitivity and Adipocyte Clusterin Associates With Cardiometabolic Risk.
+Source
+ Diabetes Care. 42(3):466-475, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bradley D; Blaszczak A; Yin Z; Liu J; Joseph JJ; Wright V; Anandani K; Needleman B; Noria S; Renton D; Yearsley M; Wong STC; Hsueh WA
+Author NameID
+ Bradley, David; ORCID: https://orcid.org/0000-0002-5777-5195
+Authors Full Name
+ Bradley, David; Blaszczak, Alecia; Yin, Zheng; Liu, Joey; Joseph, Joshua J; Wright, Valerie; Anandani, Kajol; Needleman, Bradley; Noria, Sabrena; Renton, David; Yearsley, Martha; Wong, Stephen T C; Hsueh, Willa A.
+Institution
+ Bradley, David. Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH david.bradley@osumc.edu willa.hsueh@osumc.edu stwong@houstonmethodist.org.
+ Blaszczak, Alecia. Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Yin, Zheng. Department of Systems Medicine and Bioengineering, Institute for Academic Medicine, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX.
+ Liu, Joey. Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Joseph, Joshua J. Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Wright, Valerie. Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Anandani, Kajol. Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Needleman, Bradley. Center for Minimally Invasive Surgery, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Noria, Sabrena. Center for Minimally Invasive Surgery, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Renton, David. Center for Minimally Invasive Surgery, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Yearsley, Martha. Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH.
+ Wong, Stephen T C. Department of Systems Medicine and Bioengineering, Institute for Academic Medicine, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX david.bradley@osumc.edu willa.hsueh@osumc.edu stwong@houstonmethodist.org.
+ Hsueh, Willa A. Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH david.bradley@osumc.edu willa.hsueh@osumc.edu stwong@houstonmethodist.org.
+MeSH Subject Headings
+ Adipocytes/de [Drug Effects]
+ *Adipocytes/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Adult
+ Animals
+ Biomarkers/me [Metabolism]
+ Cardiovascular Diseases/ge [Genetics]
+ Cardiovascular Diseases/me [Metabolism]
+ Cells, Cultured
+ Clusterin/ge [Genetics]
+ Clusterin/pd [Pharmacology]
+ *Clusterin/ph [Physiology]
+ Extracellular Matrix/de [Drug Effects]
+ Extracellular Matrix/ge [Genetics]
+ Extracellular Matrix/me [Metabolism]
+ Female
+ Hep G2 Cells
+ Humans
+ *Insulin/me [Metabolism]
+ *Insulin Resistance/ge [Genetics]
+ *Liver/de [Drug Effects]
+ Liver/me [Metabolism]
+ Male
+ Mice
+ Mice, Knockout
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Receptors, LDL/ge [Genetics]
+ Risk Factors
+ Subcutaneous Fat/me [Metabolism]
+Abstract
+ OBJECTIVE: Components of the adipose tissue (AT) extracellular matrix (ECM) are recently discovered contributors to obesity-related cardiometabolic disease. We identified increased adipocyte expression of ECM-related clusterin (apolipoprotein J) in obese versus lean women by microarray. Our objective was to determine 1) whether subcutaneous AT adipocyte (SAd) clusterin and serum clusterin are associated with insulin resistance (IR) and known markers of cardiometabolic risk and 2) how clusterin may contribute to increased risk.
+
+ RESEARCH DESIGN AND METHODS: We validated increased clusterin expression in adipocytes from a separate group of 18 lean and 54 obese individuals. The relationship of clusterin gene expression and plasma clusterin with IR, cardiovascular biomarkers, and risk of cardiovascular disease (CVD) was then determined. Further investigations in human cultured cells and in aged LDLR-/- mice prone to development of obesity-associated complications were performed.
+
+ RESULTS: SAd clusterin correlated with IR, multiple CVD biomarkers, and CVD risk, independent of traditional risk factors. Circulating human clusterin exhibited similar associations. In human adipocytes, palmitate enhanced clusterin secretion, and in human hepatocytes, clusterin attenuated insulin signaling and APOA1 expression and stimulated hepatic gluconeogenesis. LRP2 (megalin), a clusterin receptor, highly expressed in liver, mediated these effects, which were inhibited by LRP2 siRNA. In response to Western diet feeding, an increase in adipocyte clusterin expression was associated with a progressive increase in liver fat, steatohepatitis, and fibrosis in aged LDLR-/- mice.
+
+ CONCLUSIONS: Adipocyte-derived clusterin is a novel ECM-related protein linking cardiometabolic disease and obesity through its actions in the liver. Copyright © 2019 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CLU protein, human). 0 (Clusterin). 0 (Insulin). 0 (Receptors, LDL).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2337%2fdc18-0870
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bradley&issn=0149-5992&title=Diabetes+Care&atitle=Clusterin+Impairs+Hepatic+Insulin+Sensitivity+and+Adipocyte+Clusterin+Associates+With+Cardiometabolic+Risk.&volume=42&issue=3&spage=466&epage=475&date=2019&doi=10.2337%2Fdc18-0870&pmid=30659075&sid=OVID:medline
+
+<1540>
+Unique Identifier
+ 30933424
+Title
+ Obesity is associated with impaired responsiveness to once-daily low-dose aspirin and in vivo platelet activation.
+Source
+ Journal of Thrombosis & Haemostasis. 17(6):885-895, 2019 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Petrucci G; Zaccardi F; Giaretta A; Cavalca V; Capristo E; Cardillo C; Pitocco D; Porro B; Schinzari F; Toffolo G; Tremoli E; Rocca B
+Authors Full Name
+ Petrucci, Giovanna; Zaccardi, Francesco; Giaretta, Alberto; Cavalca, Viviana; Capristo, Esmeralda; Cardillo, Carmine; Pitocco, Dario; Porro, Benedetta; Schinzari, Francesca; Toffolo, Gianna; Tremoli, Elena; Rocca, Bianca.
+Institution
+ Petrucci, Giovanna. Istituto di Farmacologia, Universita Cattolica, Rome, Italy.
+ Petrucci, Giovanna. Fondazione Policlinico Universitario IRCCS, A. Gemelli, Rome, Italy.
+ Zaccardi, Francesco. Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK.
+ Giaretta, Alberto. Department of Information Engineering, University of Padova, Padova, Italy.
+ Cavalca, Viviana. Centro Cardiologico Monzino, IRCCS, Milano, Italy.
+ Capristo, Esmeralda. Fondazione Policlinico Universitario IRCCS, A. Gemelli, Rome, Italy.
+ Capristo, Esmeralda. Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
+ Cardillo, Carmine. Fondazione Policlinico Universitario IRCCS, A. Gemelli, Rome, Italy.
+ Cardillo, Carmine. Istituto di Patologia Medica, Universita Cattolica del Sacro Cuore, Rome, Italy.
+ Pitocco, Dario. Fondazione Policlinico Universitario IRCCS, A. Gemelli, Rome, Italy.
+ Pitocco, Dario. Diabetology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
+ Porro, Benedetta. Centro Cardiologico Monzino, IRCCS, Milano, Italy.
+ Schinzari, Francesca. Istituto di Patologia Medica, Universita Cattolica del Sacro Cuore, Rome, Italy.
+ Toffolo, Gianna. Department of Information Engineering, University of Padova, Padova, Italy.
+ Tremoli, Elena. Centro Cardiologico Monzino, IRCCS, Milano, Italy.
+ Rocca, Bianca. Istituto di Farmacologia, Universita Cattolica, Rome, Italy.
+ Rocca, Bianca. Fondazione Policlinico Universitario IRCCS, A. Gemelli, Rome, Italy.
+MeSH Subject Headings
+ Adult
+ *Aspirin/ad [Administration & Dosage]
+ Aspirin/pk [Pharmacokinetics]
+ Aspirin/pd [Pharmacology]
+ Biological Availability
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Body Weight
+ Case-Control Studies
+ Computer Simulation
+ Drug Administration Schedule
+ Female
+ Humans
+ Male
+ Middle Aged
+ Models, Biological
+ *Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pa [Pathology]
+ Pilot Projects
+ *Platelet Activation/de [Drug Effects]
+ Proof of Concept Study
+ Thromboxane A2/bi [Biosynthesis]
+ Thromboxane B2/bl [Blood]
+Keyword Heading
+ aspirin
+ body mass index
+ obesity
+ platelets
+ thromboxane A2
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The prevalence and degree of obesity is rising worldwide, increases cardiovascular risk, modifies body composition and organ function, and potentially affects the pharmacokinetics and/or pharmacodynamics of drugs.
+
+ OBJECTIVES: To investigate the pharmacodynamics of once-daily low-dose aspirin in healthy obese subjects, and to assess whether body weight (BW) and body mass index (BMI) affect the pharmacology of aspirin.
+
+ PATIENTS/METHODS: Otherwise healthy, obese (BMI > 30 kg/m2 ) subjects were studied before and after 3-4 weeks of 100-mg once-daily aspirin intake. Aspirin pharmacodynamics were assessed according to serum thromboxane (TX) B2 levels measured at 4 hours, 24 hours (i.e., posologic interval) and 48 hours after the last witnessed intake; age-matched and sex-matched non-obese controls were included. A previously calibrated pharmacokinetic/pharmacodynamic in silico model of aspirin was used to fit serum TXB2 data from obese subjects. At baseline, the major urinary TXA2 and prostacyclin metabolites, urinary isoprostane and plasma inflammatory biomarkers were measured.
+
+ RESULTS: In 16 obese subjects (aged 47 +/- 11 years; BMI of 39.4 +/- 5.1 kg/m2 ), residual serum TXB2 values between 4 and 48 hours after aspirin intake were increased 3- to 5-fold as compared with controls. At 24 hours, the residual serum TXB2 level was log-linearly associated with body size over a wide range of BMI and BW values, without any apparent threshold. The in silico model predicted that reduced aspirin bioavailability would be inversely related to body size and rescued by 200 mg of aspirin once daily or 85 mg twice daily. Baseline urinary TXA2 metabolite, isoprostane and plasma C-reactive protein levels were significantly increased in obese subjects.
+
+ CONCLUSIONS: Obesity is associated with impaired aspirin responsiveness, largely because of body size. Impaired inhibition of platelet activation by conventional low-dose aspirin may affect antithrombotic efficacy. Copyright © 2019 International Society on Thrombosis and Haemostasis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 54397-85-2 (Thromboxane B2). 57576-52-0 (Thromboxane A2). R16CO5Y76E (Aspirin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fjth.14445
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Petrucci&issn=1538-7836&title=Journal+of+Thrombosis+%26+Haemostasis&atitle=Obesity+is+associated+with+impaired+responsiveness+to+once-daily+low-dose+aspirin+and+in+vivo+platelet+activation.&volume=17&issue=6&spage=885&epage=895&date=2019&doi=10.1111%2Fjth.14445&pmid=30933424&sid=OVID:medline
+
+<1541>
+Unique Identifier
+ 30840227
+Title
+ The influence of high-fat, high-sugar diet and bariatric surgery on HSP70 and HSP90 plasma and liver concentrations in diet-induced obese rats.
+Source
+ Cell Stress & Chaperones. 24(2):427-439, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stygar D; Skrzep-Poloczek B; Romuk E; Chelmecka E; Poloczek J; Sawczyn T; Maciarz J; Kukla M; Karcz KW; Jochem J
+Author NameID
+ Stygar, Dominika; ORCID: http://orcid.org/0000-0001-8509-7507
+Authors Full Name
+ Stygar, Dominika; Skrzep-Poloczek, Bronislawa; Romuk, Ewa; Chelmecka, Elzbieta; Poloczek, Jakub; Sawczyn, Tomasz; Maciarz, Justyna; Kukla, Michal; Karcz, Konrad W; Jochem, Jerzy.
+Institution
+ Stygar, Dominika. Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland. dstygar@gmail.com.
+ Skrzep-Poloczek, Bronislawa. Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Romuk, Ewa. Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Chelmecka, Elzbieta. Department of Statistics, Department of Instrumental Analysis, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
+ Poloczek, Jakub. Department of Rehabilitation, 3rd Specialist Hospital in Rybnik, Rybnik, Poland.
+ Sawczyn, Tomasz. Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Maciarz, Justyna. Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Kukla, Michal. Department of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
+ Karcz, Konrad W. Clinic of General, Visceral, Transplantation and Vascular Surgery, Hospital of the Ludwig Maximilian University, Munich, Germany.
+ Jochem, Jerzy. Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+MeSH Subject Headings
+ Animals
+ *Bariatric Surgery/mt [Methods]
+ Biomarkers/bl [Blood]
+ *Diet, Carbohydrate Loading
+ *Diet, High-Fat
+ Disease Models, Animal
+ *HSP70 Heat-Shock Proteins/bl [Blood]
+ *HSP90 Heat-Shock Proteins/bl [Blood]
+ *Liver/me [Metabolism]
+ Male
+ Obesity/dh [Diet Therapy]
+ *Obesity/su [Surgery]
+ Rats
+ Rats, Sprague-Dawley
+Keyword Heading
+ Bariatric surgery
+ Chaperones
+ HSP70
+ HSP90
+ High-fat, high-carbohydrate diet
+ Oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Metabolic surgery ameliorates insulin resistance and is associated with long-term, effective weight loss, but the mechanisms involved remain unknown. Here, the duodenal-jejunal omega switch (DJOS) surgery in combination with high-fat, high-carbohydrate diet was performed on diet obese rats and joint effects of bariatric surgery and different dietary patterns on heat shock protein 70 (HSP70) and HSP90 plasma and liver concentrations were measured. We found that plasma and liver levels of HSP70 were lower after DJOS surgery in comparison to the control in the groups of animals kept on control diet (CD) and high-fat, high-sugar diet (HFS) but the postoperative change of the diet led to the increase in HSP70 in plasma and liver concentration in DJOS-operated animals. A high-calorie meal, rich in carbohydrates and fats, significantly increased circulating levels of HSP90, reducing the normalising effect of DJOS. The HFS diet applied during all stages of the experiment led to the higher levels of liver HSP90 concentration. The combination of CD and DJOS surgery was the most efficient in the lowering of the HSP90 liver concentration. The normalisation of circulating levels and liver concentrations of HSP70 and HSP90 may be achieved in a combination of DJOS procedure with a proper dietary plan.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (HSP70 Heat-Shock Proteins). 0 (HSP90 Heat-Shock Proteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs12192-019-00976-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stygar&issn=1355-8145&title=Cell+Stress+%26+Chaperones&atitle=The+influence+of+high-fat%2C+high-sugar+diet+and+bariatric+surgery+on+HSP70+and+HSP90+plasma+and+liver+concentrations+in+diet-induced+obese+rats.&volume=24&issue=2&spage=427&epage=439&date=2019&doi=10.1007%2Fs12192-019-00976-2&pmid=30840227&sid=OVID:medline
+
+<1542>
+Unique Identifier
+ 31476159
+Title
+ Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.
+Source
+ Journal of Alzheimer's Disease. 71(3):921-929, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Smith PJ; Mabe S; Sherwood A; Babyak MA; Doraiswamy PM; Welsh-Bohmer KA; Kraus W; Burke J; Hinderliter A; Blumenthal JA
+Authors Full Name
+ Smith, Patrick J; Mabe, Stephanie; Sherwood, Andrew; Babyak, Michael A; Doraiswamy, P Murali; Welsh-Bohmer, Kathleen A; Kraus, William; Burke, James; Hinderliter, Alan; Blumenthal, James A.
+Institution
+ Smith, Patrick J. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
+ Mabe, Stephanie. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
+ Sherwood, Andrew. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
+ Babyak, Michael A. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
+ Doraiswamy, P Murali. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
+ Welsh-Bohmer, Kathleen A. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
+ Kraus, William. Department of Medicine, Duke University Medical Center, Durham, NC, USA.
+ Burke, James. Department of Neurology, Duke University Medical Center, Durham, NC, USA.
+ Hinderliter, Alan. Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
+ Blumenthal, James A. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ *Cognition
+ *Dementia, Vascular/me [Metabolism]
+ *Dementia, Vascular/px [Psychology]
+ Executive Function
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ *Insulin Resistance
+ Insulin-Like Growth Factor I/me [Metabolism]
+ *Leptin/bl [Blood]
+ Male
+ Memory
+ Middle Aged
+ Neuropsychological Tests
+ Obesity/px [Psychology]
+Keyword Heading
+ Cognitive function
+ executive function
+ inflammation
+ insulin sensitivity
+ leptin
+ metabolic function
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Greater body weight has been associated impairments in neurocognition and greater dementia risk, although the mechanisms linking weight and neurocognition have yet to be adequately delineated.
+
+ OBJECTIVE: To examine metabolic mechanisms underlying the association between obesity and neurocognition.
+
+ METHODS: We conducted a secondary analysis of weight, neurocognition, and the potentially mediating role of metabolic and inflammatory biomarkers among 160 participants from the ENLIGHTEN trial of vascular cognitive impairment, no dementia (CIND). Neurocognition was assessed using a 45-minute assessment battery assessing Executive Function, Verbal and Visual Memory. We considered three metabolic biomarkers: insulin resistance (homeostatic model assessment [HOMA-IR]), plasma leptin, and insulin-like growth factor (IGF-1). Inflammation was assessed using C-reactive protein. Multiple regression analyses were used.
+
+ RESULTS: Participants included 160 sedentary older adults with CIND. Participants tended to be overweight or obese (mean BMI = 32.5 [SD = 4.8]). Women exhibited higher BMI (p = 0.043), CRP (p < 0.001), and leptin (p < 0.001) compared with men. Higher BMI levels were associated with worse performance on measures of Executive Function (beta= -0.16, p = 0.024) and Verbal Memory (beta= -0.16, p = 0.030), but not Visual Memory (beta= 0.05, p = 0.500). Worse metabolic biomarker profiles also were associated with lower Executive Function (beta= -0.12, p = 0.050). Mediation analyses suggested leptin was a plausible candidate as a mediator between BMI and Executive Function.
+
+ CONCLUSIONS: In overweight and obese adults with vascular CIND, the association between greater weight and poorer executive function may be mediated by higher leptin resistance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IGF1 protein, human). 0 (Leptin). 67763-96-6 (Insulin-Like Growth Factor I). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3233%2fJAD-190569
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Smith&issn=1387-2877&title=Journal+of+Alzheimer%27s+Disease&atitle=Association+Between+Insulin+Resistance%2C+Plasma+Leptin%2C+and+Neurocognition+in+Vascular+Cognitive+Impairment.&volume=71&issue=3&spage=921&epage=929&date=2019&doi=10.3233%2FJAD-190569&pmid=31476159&sid=OVID:medline
+
+<1543>
+Unique Identifier
+ 28279074
+Title
+ Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?.
+Source
+ Antioxidants & Redox Signaling. 30(2):241-250, 2019 01 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Trico D; Di Sessa A; Caprio S; Chalasani N; Liu W; Liang T; Graf J; Herzog RI; Johnson CD; Umano GR; Feldstein AE; Santoro N
+Authors Full Name
+ Trico, Domenico; Di Sessa, Anna; Caprio, Sonia; Chalasani, Naga; Liu, Wanqing; Liang, Tiebing; Graf, Joerg; Herzog, Raimund I; Johnson, Casey D; Umano, Giuseppina Rosaria; Feldstein, Ariel E; Santoro, Nicola.
+Institution
+ Trico, Domenico. 1 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
+ Di Sessa, Anna. 2 Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.
+ Caprio, Sonia. 2 Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.
+ Chalasani, Naga. 3 Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
+ Liu, Wanqing. 4 Purdue School of Pharmacy, Purdue University, West Lafayette, Indiana.
+ Liang, Tiebing. 3 Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
+ Graf, Joerg. 5 Department of Molecular and Cell Biology, University of Connecticut, Hartford, Connecticut.
+ Herzog, Raimund I. 1 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
+ Johnson, Casey D. 6 Department of Pediatrics, University of California San Diego, San Diego, California.
+ Umano, Giuseppina Rosaria. 2 Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.
+ Feldstein, Ariel E. 6 Department of Pediatrics, University of California San Diego, San Diego, California.
+ Santoro, Nicola. 2 Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.
+MeSH Subject Headings
+ Adolescent
+ Age Factors
+ Biomarkers
+ Child
+ Delta-5 Fatty Acid Desaturase
+ *Disease Susceptibility
+ Fatty Acid Desaturases/ge [Genetics]
+ Fatty Acid Desaturases/me [Metabolism]
+ Female
+ Gastrointestinal Microbiome
+ Genetic Background
+ Genetic Predisposition to Disease
+ Haplotypes
+ Humans
+ *Linoleic Acid/me [Metabolism]
+ Lipid Metabolism
+ Lipoproteins/me [Metabolism]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/et [Etiology]
+ *Metabolic Syndrome/me [Metabolism]
+ Metabolome
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Oxidation-Reduction
+Keyword Heading
+ genetic predisposition
+ gut microbiota
+ linoleic acid
+ metabolic syndrome
+ oxidized low-density lipoproteins
+ oxidized metabolites of linoleic acid
+ pediatric obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We tested whether oxidized linoleic acid metabolites (OXLAM) are associated with pediatric metabolic syndrome (MetS) and a proatherogenic lipoprotein profile in 122 obese adolescents. Furthermore, we examined whether genetic and metagenomic factors can modulate plasma OXLAM concentrations by genotyping the fatty acid desaturase 1/2 (FADS) gene and by characterizing the gut microbiota. Subjects with MetS (n = 50) showed higher concentrations of 9- and 13-oxo-octadecadienoic acid (9- and 13-oxo-ODE) than subjects without MetS (n = 72). Both metabolites were associated with an adverse lipoprotein profile that was characterized by elevated very small-dense low-density lipoprotein (p < 0.005) and large very low-density lipoprotein particles (p = 0.01). Plasma 9- and 13-oxo-ODE were higher in subjects carrying the haplotype AA of the FADS gene cluster (p = 0.030 and p = 0.048, respectively). Furthermore, the reduced gut bacterial load was associated with higher 9-oxo-ODE concentrations (p = 0.035). This is the first study showing that high plasma OXLAM concentrations are associated with MetS and suggesting that the leading factors for high plasma concentrations of OXLAM might be the genetic background and the composition of the gut microbiota. In conclusion, high concentrations of 9- and 13-oxo-ODE, which may be the result of a genetic predisposition and a reduced gut bacterial load, are associated with MetS and with a proatherogenic lipoprotein profile in obese adolescents.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Delta-5 Fatty Acid Desaturase). 0 (Lipoproteins). 9KJL21T0QJ (Linoleic Acid). EC 1-14-19 (Fatty Acid Desaturases). EC 1-14-19-3 (FADS2 protein, human).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1089%2fars.2017.7049
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Trico&issn=1523-0864&title=Antioxidants+%26+Redox+Signaling&atitle=Oxidized+Derivatives+of+Linoleic+Acid+in+Pediatric+Metabolic+Syndrome%3A+Is+Their+Pathogenic+Role+Modulated+by+the+Genetic+Background+and+the+Gut+Microbiota%3F.&volume=30&issue=2&spage=241&epage=250&date=2019&doi=10.1089%2Fars.2017.7049&pmid=28279074&sid=OVID:medline
+
+<1544>
+Unique Identifier
+ 31659186
+Title
+ Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.
+Source
+ Scientific Reports. 9(1):15385, 2019 10 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rajan MR; Sotak M; Barrenas F; Shen T; Borkowski K; Ashton NJ; Biorserud C; Lindahl TL; Ramstrom S; Scholl M; Lindahl P; Fiehn O; Newman JW; Perkins R; Wallenius V; Lange S; Borgeson E
+Author NameID
+ Sotak, Matus; ORCID: http://orcid.org/0000-0002-9984-9340
+ Fiehn, Oliver; ORCID: http://orcid.org/0000-0002-6261-8928
+ Newman, John W; ORCID: http://orcid.org/0000-0001-9632-6571
+ Perkins, Rosie; ORCID: http://orcid.org/0000-0003-2447-3286
+ Lange, Stephan; ORCID: http://orcid.org/0000-0001-9361-6602
+ Borgeson, Emma; ORCID: http://orcid.org/0000-0002-2290-9472
+Authors Full Name
+ Rajan, Meenu Rohini; Sotak, Matus; Barrenas, Fredrik; Shen, Tong; Borkowski, Kamil; Ashton, Nicholas J; Biorserud, Christina; Lindahl, Tomas L; Ramstrom, Sofia; Scholl, Michael; Lindahl, Per; Fiehn, Oliver; Newman, John W; Perkins, Rosie; Wallenius, Ville; Lange, Stephan; Borgeson, Emma.
+Institution
+ Rajan, Meenu Rohini. Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Rajan, Meenu Rohini. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Sotak, Matus. Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Sotak, Matus. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Barrenas, Fredrik. Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Barrenas, Fredrik. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Barrenas, Fredrik. Department of Cell & Molecular Biology, Uppsala University, Uppsala, Sweden.
+ Shen, Tong. NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA.
+ Borkowski, Kamil. NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA.
+ Ashton, Nicholas J. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Ashton, Nicholas J. Department of Psychiatry and Neurochemistry, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden.
+ Ashton, Nicholas J. King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.
+ Ashton, Nicholas J. NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, London, UK.
+ Biorserud, Christina. Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
+ Lindahl, Tomas L. Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden.
+ Ramstrom, Sofia. Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden.
+ Ramstrom, Sofia. Cardiovascular Research Centre, School of Medical Sciences, Orebro University, Orebro, Sweden.
+ Scholl, Michael. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Scholl, Michael. Department of Psychiatry and Neurochemistry, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden.
+ Scholl, Michael. Dementia Research Centre, Institute of Neurology, University College London, London, UK.
+ Lindahl, Per. Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Fiehn, Oliver. NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA.
+ Newman, John W. NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA.
+ Newman, John W. Department of Nutrition, University of California Davis, Davis, USA.
+ Newman, John W. USDA, ARS, Western Human Nutrition Research Center, Davis, USA.
+ Perkins, Rosie. Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Wallenius, Ville. Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
+ Lange, Stephan. Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
+ Lange, Stephan. Division of Cardiology, School of Medicine, University of California San Diego, San Diego, USA.
+ Borgeson, Emma. Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. emma.borgeson@wlab.gu.se.
+ Borgeson, Emma. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden. emma.borgeson@wlab.gu.se.
+ Borgeson, Emma. Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden. emma.borgeson@wlab.gu.se.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Female
+ Humans
+ *Kidney Diseases/bl [Blood]
+ Kidney Diseases/co [Complications]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/co [Complications]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Plasminogen Activator Inhibitor 1/bl [Blood]
+ Plasminogen Activator Inhibitor 1/st [Standards]
+ *Proprotein Convertase 9/bl [Blood]
+ Proprotein Convertase 9/st [Standards]
+Abstract
+ The search for biomarkers associated with obesity-related diseases is ongoing, but it is not clear whether plasma and serum can be used interchangeably in this process. Here we used high-throughput screening to analyze 358 proteins and 76 lipids, selected because of their relevance to obesity-associated diseases, in plasma and serum from age- and sex-matched lean and obese humans. Most of the proteins/lipids had similar concentrations in plasma and serum, but a subset showed significant differences. Notably, a key marker of cardiovascular disease PAI-1 showed a difference in concentration between the obese and lean groups only in plasma. Furthermore, some biomarkers showed poor correlations between plasma and serum, including PCSK9, an important regulator of cholesterol homeostasis. Collectively, our results show that the choice of biofluid may impact study outcome when screening for obesity-related biomarkers and we identify several markers where this will be the case.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Plasminogen Activator Inhibitor 1). EC 3-4-21 (PCSK9 protein, human). EC 3-4-21 (Proprotein Convertase 9).
+Publication Type
+ Clinical Trial. Comparative Study. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-51673-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rajan&issn=2045-2322&title=Scientific+Reports&atitle=Comparative+analysis+of+obesity-related+cardiometabolic+and+renal+biomarkers+in+human+plasma+and+serum.&volume=9&issue=1&spage=15385&epage=&date=2019&doi=10.1038%2Fs41598-019-51673-0&pmid=31659186&sid=OVID:medline
+
+<1545>
+Unique Identifier
+ 30909396
+Title
+ Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats.
+Source
+ Molecules. 24(6), 2019 Mar 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Luo Q; Cheng D; Huang C; Li Y; Lao C; Xia Y; Liu W; Gong X; Hu D; Li B; He X; Chen Z
+Author NameID
+ Chen, Zhengli; ORCID: https://orcid.org/0000-0002-9850-528X
+Authors Full Name
+ Luo, Qihui; Cheng, Dongjing; Huang, Chao; Li, Yifan; Lao, Chengjie; Xia, Yu; Liu, Wentao; Gong, Xiaoxia; Hu, Danlei; Li, Bin; He, Xue; Chen, Zhengli.
+Institution
+ Luo, Qihui. Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. lqhbiology@163.com.
+ Luo, Qihui. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. lqhbiology@163.com.
+ Cheng, Dongjing. Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. chengdongjing@126.com.
+ Cheng, Dongjing. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. chengdongjing@126.com.
+ Huang, Chao. Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. huangchao@sicau.edu.cn.
+ Huang, Chao. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. huangchao@sicau.edu.cn.
+ Li, Yifan. Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. yifanli0817@163.com.
+ Li, Yifan. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. yifanli0817@163.com.
+ Lao, Chengjie. Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. laocj163@163.com.
+ Lao, Chengjie. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. laocj163@163.com.
+ Xia, Yu. Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. xiayu113bvs@163.com.
+ Xia, Yu. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. xiayu113bvs@163.com.
+ Liu, Wentao. Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. liuwt1986@126.com.
+ Liu, Wentao. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. liuwt1986@126.com.
+ Gong, Xiaoxia. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. gongxx0601@163.com.
+ Hu, Danlei. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. hudlo226@163.com.
+ Li, Bin. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. LinBin344@163.com.
+ He, Xue. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. HXzm159@163.com.
+ Chen, Zhengli. Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. chzhli75@163.com.
+ Chen, Zhengli. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. chzhli75@163.com.
+MeSH Subject Headings
+ Animals
+ Biodiversity
+ Biomarkers
+ Body Weight/de [Drug Effects]
+ *Colon/de [Drug Effects]
+ *Colon/im [Immunology]
+ Colon/me [Metabolism]
+ Cytokines/ge [Genetics]
+ Cytokines/me [Metabolism]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Dietary Supplements
+ Disease Models, Animal
+ Gastrointestinal Microbiome/de [Drug Effects]
+ Gene Expression
+ Gene Expression Regulation
+ *Immunomodulation/de [Drug Effects]
+ Immunomodulation/ge [Genetics]
+ Intestinal Mucosa/de [Drug Effects]
+ Intestinal Mucosa/im [Immunology]
+ Intestinal Mucosa/me [Metabolism]
+ Isoflavones/ch [Chemistry]
+ *Isoflavones/pd [Pharmacology]
+ Lipid Peroxidation/de [Drug Effects]
+ Male
+ NF-kappa B/me [Metabolism]
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Oxidative Stress/de [Drug Effects]
+ Plant Extracts
+ Rats
+ Signal Transduction
+ Glycine max/ch [Chemistry]
+ Toll-Like Receptor 4/me [Metabolism]
+Keyword Heading
+ colon
+ intestinal barrier function
+ obesity
+ soy isoflavones
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: The damage to intestinal barrier function plays an important role in the development of obesity and associated diseases. Soy isoflavones are effective natural active components for controlling obesity and reducing the level of blood lipid. Here, we explored whether these effects of soy isoflavones were associated with the intestinal barrier function. Methods and Results: The obese rat models were established by high fat diet feeding. Then, those obese rats were supplemented with soy isoflavones at different doses for 4 weeks. Our results showed that obesity induced the expressions of pro-inflammatory cytokines, decreased the anti-inflammatory cytokine (IL-10) expression, elevated intestinal permeability, altered gut microbiota and exacerbated oxidative damages in colon. The administration of soy isoflavones reversed these changes in obese rats, presenting as the improvement of intestinal immune function and permeability, attenuation of oxidative damage, increase in the fraction of beneficial bacteria producing short-chain fatty acids and short-chain fatty acid production, and reduction in harmful bacteria. Furthermore, soy isoflavones blocked the expressions of TLR4 and NF-kappaB in the colons of the obese rats. Conclusions: Soy isoflavones could improve obesity through the attenuation of intestinal oxidative stress, recovery of immune and mucosal barrier, as well as re-balance of intestinal gut microbiota.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Isoflavones). 0 (NF-kappa B). 0 (Plant Extracts). 0 (Toll-Like Receptor 4).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fmolecules24061139
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Luo&issn=1420-3049&title=Molecules&atitle=Improvement+of+Colonic+Immune+Function+with+Soy+Isoflavones+in+High-Fat+Diet-Induced+Obese+Rats.&volume=24&issue=6&spage=1139&epage=&date=2019&doi=10.3390%2Fmolecules24061139&pmid=30909396&sid=OVID:medline
+
+<1546>
+Unique Identifier
+ 29965796
+Title
+ Circadian period of luciferase expression shortens with age in human mature adipocytes from obese patients.
+Source
+ FASEB Journal. 33(1):175-180, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kolbe I; Carrasco-Benso MP; Lopez-Minguez J; Lujan J; Scheer FAJL; Oster H; Garaulet M
+Authors Full Name
+ Kolbe, Isa; Carrasco-Benso, Maria Paz; Lopez-Minguez, Jesus; Lujan, Juan; Scheer, Frank A J L; Oster, Henrik; Garaulet, Marta.
+Institution
+ Kolbe, Isa. Institute of Neurobiology, University of Lubeck, Lubeck, Germany.
+ Carrasco-Benso, Maria Paz. Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain.
+ Carrasco-Benso, Maria Paz. Biomedical Research Institute, Murcia, Spain.
+ Lopez-Minguez, Jesus. Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain.
+ Lopez-Minguez, Jesus. Biomedical Research Institute, Murcia, Spain.
+ Lujan, Juan. General Surgery Service, University Hospital Virgen de la Arrixaca, Murcia, Spain; and.
+ Scheer, Frank A J L. Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.
+ Scheer, Frank A J L. Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
+ Oster, Henrik. Institute of Neurobiology, University of Lubeck, Lubeck, Germany.
+ Garaulet, Marta. Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain.
+ Garaulet, Marta. Biomedical Research Institute, Murcia, Spain.
+MeSH Subject Headings
+ ARNTL Transcription Factors/me [Metabolism]
+ Adipocytes/cy [Cytology]
+ *Adipocytes/me [Metabolism]
+ Adipose Tissue/cy [Cytology]
+ *Adipose Tissue/me [Metabolism]
+ Adult
+ Age Factors
+ *Biomarkers/me [Metabolism]
+ Body Mass Index
+ *Circadian Rhythm
+ Female
+ Humans
+ *Luciferases/me [Metabolism]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Signal Transduction
+Keyword Heading
+ reporter
+ adipose tissue
+ lenti virus
+ peripheral clocks
+ primary cells
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Daily rhythms in physiology and behavior change with age. An unresolved question is to what extent such age-related alterations in circadian organization are driven by the central clock in the suprachiasmatic nucleus (SCN), modifying timing signals to contributing peripheral tissue oscillators, and are mediated by underlying changes in the local cellular oscillators themselves. Using a bioluminescence reporter approach, we sought to determine whether circadian clock function in human adipocytes from subcutaneous (SAT) and visceral (VAT) adipose tissues changes with age. SAT and VAT biopsies were obtained from obese individuals during gastric bypass surgeries [ n = 16; body mass index: 44.8 +/- 11.4 kg/m2; age: 44 +/- 9 yr (range: 30-58)]. Cells were isolated and transduced with a lentiviral circadian reporter construct [brain and muscle aryl hydrocarbon receptor nuclear translocator-like:luciferase ( BMAL:LUC)], and bioluminescence was recorded over a period of 3 d. Human BMAL1:LUC adipocytes displayed a robust luminescence rhythm with comparable within-individual periods in mature and preadipocytes ( P > 0.05). With increasing age, the circadian period decreased in mature adipocytes ( P = 0.005) (beta = 4 min/yr; P < 0.05). Our ex vivo approach indicated that ageing changes the organization of endogenous circadian oscillators in human adipocytes, independent of SCN signaling.-Kolbe, I., Carrasco-Benso, M. P., Lopez-Minguez, J., Lujan, J., Scheer, F. A. J. L., Oster, H., Garaulet, M. Circadian period of luciferase expression shortens with age in human mature adipocytes from obese patients.
+Registry Number/Name of Substance
+ 0 (ARNTL Transcription Factors). 0 (BMAL1 protein, human). 0 (Biomarkers). EC 1-13-12 (Luciferases).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1096%2ffj.201800441R
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kolbe&issn=0892-6638&title=FASEB+Journal&atitle=Circadian+period+of+luciferase+expression+shortens+with+age+in+human+mature+adipocytes+from+obese+patients.&volume=33&issue=1&spage=175&epage=180&date=2019&doi=10.1096%2Ffj.201800441R&pmid=29965796&sid=OVID:medline
+
+<1547>
+Unique Identifier
+ 31386638
+Title
+ High high-sensitivity C-reactive protein/BMI ratio predicts future adverse outcomes in patients with acute coronary syndrome.
+Source
+ Coronary Artery Disease. 30(6):448-454, 2019 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jia L; Yuan JQ; Zhu L; Zhang Y
+Authors Full Name
+ Jia, Lei; Yuan, Jin-Qing; Zhu, Ling; Zhang, Yin.
+Institution
+ Jia, Lei. State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
+ Yuan, Jin-Qing. State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
+ Zhu, Ling. Department of Cardiovascular Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, China.
+ Zhang, Yin. State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
+MeSH Subject Headings
+ Acute Coronary Syndrome/bl [Blood]
+ *Acute Coronary Syndrome/di [Diagnosis]
+ Acute Coronary Syndrome/mo [Mortality]
+ Acute Coronary Syndrome/th [Therapy]
+ Aged
+ Biomarkers
+ *Body Mass Index
+ *C-Reactive Protein/an [Analysis]
+ China
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/mo [Mortality]
+ Percutaneous Coronary Intervention
+ Predictive Value of Tests
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Time Factors
+Abstract
+ OBJECTIVE: The prognostic value of high-sensitivity C-reactive protein (hsCRP) and obesity in patients with coronary artery disease is controversial. In previous studies, hsCRP was significantly associated with BMI. Thus, we integrated hsCRP and BMI to assess the predictive value in patients with acute coronary syndrome (ACS).
+
+ METHODS AND RESULTS: In this observational cohort study, 478 patients with ACS were enrolled in Fuwai Hospital from 2010 to 2011,with a mean follow-up of 4.2 years. The endpoint of major adverse cardiovascular events (MACE) was the composite of cardiovascular death, myocardial infarction, revascularization again, heart failure, or stroke. Compared with patients without MACE, we found that patients with MACE had higher hsCRP (3.86 +/- 3.66 vs. 3.00 +/- 3.17, P = 0.033). Furthermore, we identified that hsCRP was significantly correlated with BMI (r = 0.134, P = 0.005). Thus, hsCRP level was adjusted by BMI to further clarify its role in the prognosis of patients with ACS. According to the tertiles of hsCRP/BMI ratio, the rates of MACE in the lowest tertile group, the median tertile group, and the highest tertile group were 14.0% (21/150), 14.0% (21/150), and 26% (39/150) (P = 0.008), respectively. In multivariate analysis, hsCRP/BMI was independently and positively related to MACE. Similarly, according to risk category of hsCRP (low hsCRP group < 3.0 mg/l, high hsCRP group >= 3.0 mg/l) and BMI (< 24 and >= 24.0 kg/m), patients in the high hsCRP but normal or low weight group had the lowest MACE-free survival (log-rank P = 0.003) compared with other groups.
+
+ CONCLUSION: We confirmed that C-reactive protein level should be adjusted by BMI to reflect the prognosis of patients with ACS. High hsCRP/BMI ratio was associated with adverse outcomes. Patients with ACS with high hsCRP plus overweight had the same risk for MACE as those with lower hsCRP but normal weight.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fMCA.0000000000000719
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jia&issn=0954-6928&title=Coronary+Artery+Disease&atitle=High+high-sensitivity+C-reactive+protein%2FBMI+ratio+predicts+future+adverse+outcomes+in+patients+with+acute+coronary+syndrome.&volume=30&issue=6&spage=448&epage=454&date=2019&doi=10.1097%2FMCA.0000000000000719&pmid=31386638&sid=OVID:medline
+
+<1548>
+Unique Identifier
+ 31383505
+Title
+ Temporal relationship between body mass index and triglyceride-glucose index and its impact on the incident of hypertension.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 29(11):1220-1229, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xie Y; Guo R; Li Z; Guo X; Sun G; Sun Z; Zheng J; Sun Y; Zheng L
+Authors Full Name
+ Xie, Yanxia; Guo, Rongrong; Li, Zhao; Guo, Xiaofan; Sun, Guozhe; Sun, Zhaoqing; Zheng, Jia; Sun, Yingxian; Zheng, Liqiang.
+Institution
+ Xie, Yanxia. Department of Clinical Epidemiology, Library, Department of Health Policy and Hospital Management, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, PR China.
+ Guo, Rongrong. Department of Clinical Epidemiology, Library, Department of Health Policy and Hospital Management, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, PR China.
+ Li, Zhao. Department of Cardiology, The First Affiliated Hospital of China Medical University, 155 Nanjing Street, Heping District, Shenyang, 110001, PR China.
+ Guo, Xiaofan. Department of Cardiology, The First Affiliated Hospital of China Medical University, 155 Nanjing Street, Heping District, Shenyang, 110001, PR China.
+ Sun, Guozhe. Department of Cardiology, The First Affiliated Hospital of China Medical University, 155 Nanjing Street, Heping District, Shenyang, 110001, PR China.
+ Sun, Zhaoqing. Department of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, PR China.
+ Zheng, Jia. Department of Clinical Epidemiology, Library, Department of Health Policy and Hospital Management, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, PR China.
+ Sun, Yingxian. Department of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, PR China. Electronic address: sunyingxian12@126.com.
+ Zheng, Liqiang. Department of Clinical Epidemiology, Library, Department of Health Policy and Hospital Management, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, PR China. Electronic address: liqiangzheng@126.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Blood Pressure
+ *Body Mass Index
+ Female
+ Health Status Disparities
+ Humans
+ Hyperinsulinism/bl [Blood]
+ Hyperinsulinism/di [Diagnosis]
+ *Hyperinsulinism/ep [Epidemiology]
+ Hyperinsulinism/pp [Physiopathology]
+ Hypertension/bl [Blood]
+ Hypertension/di [Diagnosis]
+ *Hypertension/ep [Epidemiology]
+ Hypertension/pp [Physiopathology]
+ Incidence
+ *Insulin Resistance
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Rural Health
+ Sex Factors
+ Time Factors
+ *Triglycerides/bl [Blood]
+Keyword Heading
+ Hypertension
+ Insulin resistance
+ Obesity
+ Rural adults
+ Temporal relationship
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Obesity and insulin levels can influence each other by metabolism. However, their temporal sequences and influence on hypertension are generally unknown, especially in Chinese adults. Recently, some scholars have proposed that triglycerides-glucose index (TyG) is an important indicator of insulin resistance. The study aims to describe the relationship between body mass index (BMI) and TyG index and its impact on hypertension.
+
+ METHODS AND RESULTS: A total of 4081 adults (56.33% women) without antihypertensive, hypoglycemic or lipid-lowering medications were selected for the present study. Measurements of BMI and TyG index were obtained twice from 2012 to 2017. Cross-lagged panel analysis was used to describe the temporal sequences between BMI and TyG index, and the effect of their temporal relationship patterns on hypertension was explored through mediation analysis. After adjusting for confounding factors (age, sex, ethnicity et al.), the cross-lagged path coefficient from baseline BMI to follow-up TyG (rho2 = 0.135, P < 0.001) was significantly greater than the path coefficient from baseline TyG to follow-up BMI (rho1 = 0.043, P < 0.001), and P < 0.001 for the difference between rho1 and rho2. Furthermore, the sensitivity analyses between women and men revealed identical findings. In addition, TyG index mediation effect on BMI-hypertension was estimated to be 38.45% (P < 0.001) in total population, 25.24% in women and 57.35% in men.
+
+ CONCLUSION: These results provided evidence that the temporal relationship between BMI and insulin resistance is reciprocal and a higher BMI precedes hyperinsulinemia in Chinese adults. This relationship plays an essential role in the development of hypertension, while there is a difference between women and men. Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.numecd.2019.07.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xie&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Temporal+relationship+between+body+mass+index+and+triglyceride-glucose+index+and+its+impact+on+the+incident+of+hypertension.&volume=29&issue=11&spage=1220&epage=1229&date=2019&doi=10.1016%2Fj.numecd.2019.07.003&pmid=31383505&sid=OVID:medline
+
+<1549>
+Unique Identifier
+ 31375523
+Title
+ Preoperative Circulating Succinate Levels as a Biomarker for Diabetes Remission After Bariatric Surgery.
+Source
+ Diabetes Care. 42(10):1956-1965, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ceperuelo-Mallafre V; Llaurado G; Keiran N; Benaiges E; Astiarraga B; Martinez L; Pellitero S; Gonzalez-Clemente JM; Rodriguez A; Fernandez-Real JM; Lecube A; Megia A; Vilarrasa N; Vendrell J; Fernandez-Veledo S
+Author NameID
+ Lecube, Albert; ORCID: https://orcid.org/0000-0001-9684-0183
+ Vendrell, Joan; ORCID: https://orcid.org/0000-0002-6994-6115
+Authors Full Name
+ Ceperuelo-Mallafre, Victoria; Llaurado, Gemma; Keiran, Noelia; Benaiges, Ester; Astiarraga, Brenno; Martinez, Laia; Pellitero, Silvia; Gonzalez-Clemente, Jose Miguel; Rodriguez, Amaia; Fernandez-Real, Jose Manuel; Lecube, Albert; Megia, Ana; Vilarrasa, Nuria; Vendrell, Joan; Fernandez-Veledo, Sonia.
+Institution
+ Ceperuelo-Mallafre, Victoria. Institut d'Investigacio Sanitaria Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
+ Ceperuelo-Mallafre, Victoria. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Llaurado, Gemma. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Llaurado, Gemma. Department of Endocrinology and Nutrition, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain.
+ Keiran, Noelia. Institut d'Investigacio Sanitaria Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
+ Keiran, Noelia. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Benaiges, Ester. Institut d'Investigacio Sanitaria Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
+ Benaiges, Ester. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Astiarraga, Brenno. Institut d'Investigacio Sanitaria Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
+ Astiarraga, Brenno. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Astiarraga, Brenno. Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio Biomedica de Girona, CIBEROBN (CB06/03/010) and ISCIII, Girona, Spain.
+ Martinez, Laia. Institut d'Investigacio Sanitaria Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
+ Pellitero, Silvia. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Pellitero, Silvia. Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain.
+ Gonzalez-Clemente, Jose Miguel. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Gonzalez-Clemente, Jose Miguel. Department of Endocrinology and Nutrition, Hospital de Sabadell, Corporacio Sanitaria Parc Tauli, Institut d'Investigacio i Innovacio Parc Tauli (Universitat Autonoma de Barcelona), Sabadell, Spain.
+ Rodriguez, Amaia. Metabolic Research Laboratory, Clinica Universidad de Navarra, CIBEROBN, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain.
+ Fernandez-Real, Jose Manuel. Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio Biomedica de Girona, CIBEROBN (CB06/03/010) and ISCIII, Girona, Spain.
+ Lecube, Albert. Endocrinology and Nutrition Department, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
+ Megia, Ana. Institut d'Investigacio Sanitaria Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
+ Megia, Ana. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Vilarrasa, Nuria. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Vilarrasa, Nuria. Obesity Unit and Endocrinology and Nutrition Departments, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Vendrell, Joan. Institut d'Investigacio Sanitaria Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain sonia.fernandezveledo@gmail.com jvo@comt.es.
+ Vendrell, Joan. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Vendrell, Joan. Rovira I Virgili University, Tarragona, Spain.
+ Fernandez-Veledo, Sonia. Institut d'Investigacio Sanitaria Pere Virgili, Endocrinology and Nutrition Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain sonia.fernandezveledo@gmail.com jvo@comt.es.
+ Fernandez-Veledo, Sonia. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adult
+ Aged
+ Bariatric Surgery/mt [Methods]
+ *Bariatric Surgery
+ *Biomarkers/bl [Blood]
+ Cohort Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/su [Surgery]
+ Female
+ Humans
+ Laparoscopy/mt [Methods]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity/su [Surgery]
+ Preoperative Period
+ Prognosis
+ Remission Induction
+ *Succinic Acid/bl [Blood]
+ Treatment Outcome
+ Weight Loss
+Abstract
+ OBJECTIVE: To determine the potential use of baseline circulating succinate to predict type 2 diabetes remission after bariatric surgery.
+
+ RESEARCH DESIGN AND METHODS: Forty-five obese patients with diabetes were randomly assigned to Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), or laparoscopic greater curvature plication. Anthropometric parameters were evaluated, and a complete biochemical analysis including circulating serum succinate concentrations was performed at baseline and 1 year after surgery. The results were externally validated in a second cohort including 88 obese patients with diabetes assigned to RYGB or SG based on clinical criteria.
+
+ RESULTS: Succinate baseline concentrations were an independent predictor of diabetes remission after bariatric surgery. Patients achieving remission after 1 year had lower levels of baseline succinate (47.8 [37.6-64.6] micromol/L vs. 64.1 [52.5-82.9] micromol/L; P = 0.018). Moreover, succinate concentrations were significantly decreased 1 year after surgery (58.9 [46.4-82.4] micromol/L vs. 46.0 [35.8-65.3] micromol/L, P = 0.005). In multivariate analysis, the best logistic regression model showed that baseline succinate (odds ratio [OR] 11.3, P = 0.031) and the type of surgery (OR 26.4, P = 0.010) were independently associated with remission. The C-statistic for this model was 0.899 (95% CI 0.809-0.989) in the derivation cohort, which significantly improved the prediction of remission compared with current available scores, and 0.729 (95% CI 0.612-0.846) in the validation cohort. Interestingly, patients had a different response to the type of surgery according to baseline succinate, with significant differences in remission rates.
+
+ CONCLUSIONS: Circulating succinate is reduced after bariatric surgery. Baseline succinate levels have predictive value for diabetes remission independently of previously described presurgical factors and improve upon the current available scores to predict remission. Copyright © 2019 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). AB6MNQ6J6L (Succinic Acid).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2337%2fdc19-0114
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ceperuelo-Mallafre&issn=0149-5992&title=Diabetes+Care&atitle=Preoperative+Circulating+Succinate+Levels+as+a+Biomarker+for+Diabetes+Remission+After+Bariatric+Surgery.&volume=42&issue=10&spage=1956&epage=1965&date=2019&doi=10.2337%2Fdc19-0114&pmid=31375523&sid=OVID:medline
+
+<1550>
+Unique Identifier
+ 31369706
+Title
+ Omega-3 Fatty Acids Responsive Proteins and Reduction in Breast Density in Obese Postmenopausal Women.
+Source
+ Journal of Proteome Research. 18(9):3461-3469, 2019 09 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sun YW; Xu H; Benitez G; Chen KM; Stanley A; Stanley B; Zhu J; Thompson H; Manni A; El-Bayoumy K
+Author NameID
+ Sun, Yuan-Wan; ORCID: https://orcid.org/0000-0002-2028-3533
+ Xu, Haifang; ORCID: https://orcid.org/0000-0003-0317-6039
+ Benitez, Gabrielle; ORCID: https://orcid.org/0000-0002-3564-9462
+ Chen, Kun-Ming; ORCID: https://orcid.org/0000-0002-3820-6149
+ Stanley, Anne; ORCID: https://orcid.org/0000-0003-1224-0952
+ Stanley, Bruce; ORCID: https://orcid.org/0000-0003-1338-2928
+ Zhu, Junjia; ORCID: https://orcid.org/0000-0003-1311-3752
+ Thompson, Henry; ORCID: https://orcid.org/0000-0002-3730-9322
+ Manni, Andrea; ORCID: https://orcid.org/0000-0002-1222-7814
+ El-Bayoumy, Karam; ORCID: https://orcid.org/0000-0002-4198-0696
+Authors Full Name
+ Sun, Yuan-Wan; Xu, Haifang; Benitez, Gabrielle; Chen, Kun-Ming; Stanley, Anne; Stanley, Bruce; Zhu, Junjia; Thompson, Henry; Manni, Andrea; El-Bayoumy, Karam.
+Institution
+ Manni, Andrea. Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, United States.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Breast Density/de [Drug Effects]
+ *Breast Neoplasms/bl [Blood]
+ Breast Neoplasms/dt [Drug Therapy]
+ Breast Neoplasms/pa [Pathology]
+ Docosahexaenoic Acids/ad [Administration & Dosage]
+ *Docosahexaenoic Acids/bl [Blood]
+ Drug Combinations
+ Eicosapentaenoic Acid/ad [Administration & Dosage]
+ *Eicosapentaenoic Acid/bl [Blood]
+ Fatty Acids, Omega-3/ad [Administration & Dosage]
+ Fatty Acids, Omega-3/bl [Blood]
+ Female
+ Fibronectins/ge [Genetics]
+ Gene Expression Regulation/de [Drug Effects]
+ Hemopexin/ge [Genetics]
+ Humans
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/dt [Drug Therapy]
+ Obesity/pa [Pathology]
+ Postmenopause/bl [Blood]
+ Proteomics/mt [Methods]
+ Vitamin D-Binding Protein/ge [Genetics]
+ Young Adult
+ alpha-Macroglobulins/ge [Genetics]
+Keyword Heading
+ breast density
+ carcinogenesis
+ inflammation
+ lipogenesis
+ n-3FA
+ obesity
+ proteomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We reported that breast density (BD) was inversely correlated with the plasma level of DHA in postmenopausal obese, but not in nonobese, women given Lovaza (n-3FA). To identify protein biomarkers for the possible differential effect of n-3FA on BD between obese and nonobese women, an iTRAQ method was performed to analyze plasma from obese and lean women at each time point (baseline, 12 and 24-months, n = 10 per group); 173 proteins with >95% confidence (Unuses Score >1.3 and local false discovery rate estimation <5%) were identified. Comparative analysis between various groups identified several differentially expressed proteins (hemopexin precursor, vitamin D binding protein isoform 1 precursor [VDBP], fibronectin isoform 10 precursor [FN], and alpha-2 macroglobulin precursor [A2M]). Western blot analysis was performed to verify the differential expression of proteins in the iTRAQ study, and those found to be altered in a tumor protective fashion by an n-3FA rich diet in our previous preclinical study; gelsolin, VDBP, and FN were altered by n-3FA in a manner consistent with reduction in inflammation in obese women. To test the impact of our findings on breast cancer risk reduction by n-3FA, a posthoc analysis revealed that n-3FA administration reduced BD selectively in obese postmenopausal women.
+Registry Number/Name of Substance
+ 0 (A2M protein, human). 0 (Biomarkers). 0 (Drug Combinations). 0 (Fatty Acids, Omega-3). 0 (Fibronectins). 0 (GC protein, human). 0 (Vitamin D-Binding Protein). 0 (alpha-Macroglobulins). 25167-62-8 (Docosahexaenoic Acids). 9013-71-2 (Hemopexin). AAN7QOV9EA (Eicosapentaenoic Acid). D87YGH4Z0Q (Omacor).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1021%2facs.jproteome.9b00356
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sun&issn=1535-3893&title=Journal+of+Proteome+Research&atitle=Omega-3+Fatty+Acids+Responsive+Proteins+and+Reduction+in+Breast+Density+in+Obese+Postmenopausal+Women.&volume=18&issue=9&spage=3461&epage=3469&date=2019&doi=10.1021%2Facs.jproteome.9b00356&pmid=31369706&sid=OVID:medline
+
+<1551>
+Unique Identifier
+ 31365708
+Title
+ The role of visfatin levels in gingival crevicular fluid as a potential biomarker in the relationship between obesity and periodontal disease.
+Source
+ Journal of Applied Oral Science. 27:e20180365, 2019 Jul 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cetiner D; Uraz A; Oztoprak S; Akca G
+Author NameID
+ Uraz, Ahu; ORCID: http://orcid.org/0000-0001-6281-6855
+Authors Full Name
+ Cetiner, Deniz; Uraz, Ahu; Oztoprak, Seniha; Akca, Gulcin.
+Institution
+ Cetiner, Deniz. Gazi University, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey.
+ Uraz, Ahu. Gazi University, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey.
+ Oztoprak, Seniha. Gazi University, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey.
+ Akca, Gulcin. Gazi University, Faculty of Dentistry, Department of Microbiology, Ankara, Turkey.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ *Cytokines/an [Analysis]
+ Cytokines/ph [Physiology]
+ Female
+ *Gingival Crevicular Fluid/ch [Chemistry]
+ Humans
+ *Interleukin-6/an [Analysis]
+ Interleukin-6/ph [Physiology]
+ Male
+ Middle Aged
+ *Nicotinamide Phosphoribosyltransferase/an [Analysis]
+ Nicotinamide Phosphoribosyltransferase/ph [Physiology]
+ *Obesity/me [Metabolism]
+ Periodontal Index
+ Periodontitis/dg [Diagnostic Imaging]
+ *Periodontitis/me [Metabolism]
+ Radiography, Panoramic
+ Reference Values
+ Statistics, Nonparametric
+ *Tumor Necrosis Factor-alpha/an [Analysis]
+ Tumor Necrosis Factor-alpha/ph [Physiology]
+Abstract
+ OBJECTIVES: Visfatin is an adipokine that plays an important role in immune functions as a growth factor, enzyme, and pro-inflammatory mediator. We aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP).
+
+ METHODOLOGY: Patients were categorized as obese (O) (n=31) or non-obese (nO) (n=19). Groups were divided into four subgroups according to periodontal conditions: (1) periodontally healthy without obesity (nO-Ctrl); (2) GCP without obesity (nO-CP); (3) periodontally healthy with obesity (O-Ctrl); and (4) GCP with obesity (O-CP). Demographic variables, anthropometric and laboratory data were recorded. Periodontal parameters were measured at baseline and 3rd months after either non-surgical periodontal treatment or calorie -restricted diet therapy. At the same time, GCF samples were taken from patients to analyze TNF-alpha, IL-6,and visfatin levels.
+
+ RESULTS: Periodontal parameters were significantly higher in the O group than in the nO group (P<0.05). IL-6 levels were higher in the O group than in the nO group (P<0.001). The visfatin levels of the obese patients were reduceddecreased following the treatments (P<0.05). Cholesterol levels were higher in the O group than in the nO groups (P<0.05). IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05). Compared to the other groups, visfatin levels were significantly higher in the O-CP group but decreased following treatment (P<0.05).
+
+ CONCLUSIONS: Our findings suggest that visfatin and IL-6 levels in GCF are associated with the pathogenesis of obesity and periodontitis. Within the limits of this study, we considered that there might be an association between the lipid profile and periodontitis on systemically healthy individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase). EC 2-4-2-12 (nicotinamide phosphoribosyltransferase, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1590%2f1678-7757-2018-0365
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cetiner&issn=1678-7757&title=Journal+of+Applied+Oral+Science&atitle=The+role+of+visfatin+levels+in+gingival+crevicular+fluid+as+a+potential+biomarker+in+the+relationship+between+obesity+and+periodontal+disease.&volume=27&issue=&spage=e20180365&epage=&date=2019&doi=10.1590%2F1678-7757-2018-0365&pmid=31365708&sid=OVID:medline
+
+<1552>
+Unique Identifier
+ 31362440
+Title
+ Phase Angle: A Possible Biomarker to Quantify Inflammation in Subjects with Obesity and 25(OH)D Deficiency.
+Source
+ Nutrients. 11(8), 2019 07 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Barrea L; Muscogiuri G; Laudisio D; Di Somma C; Salzano C; Pugliese G; de Alteriis G; Colao A; Savastano S
+Authors Full Name
+ Barrea, Luigi; Muscogiuri, Giovanna; Laudisio, Daniela; Di Somma, Carolina; Salzano, Ciro; Pugliese, Gabriella; de Alteriis, Giulia; Colao, Annamaria; Savastano, Silvia.
+Institution
+ Barrea, Luigi. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy. luigi.barrea@unina.it.
+ Muscogiuri, Giovanna. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Laudisio, Daniela. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Di Somma, Carolina. IRCCS, SDN, Via Gianturco 113, 80143 Naples, Italy.
+ Salzano, Ciro. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Pugliese, Gabriella. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
+ de Alteriis, Giulia. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Colao, Annamaria. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
+ Savastano, Silvia. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
+MeSH Subject Headings
+ Adiposity
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ *Body Composition
+ Body Mass Index
+ Cross-Sectional Studies
+ Electric Impedance
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/di [Diagnosis]
+ Inflammation/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ Predictive Value of Tests
+ Reproducibility of Results
+ *Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ Vitamin D Deficiency/bl [Blood]
+ *Vitamin D Deficiency/di [Diagnosis]
+ Vitamin D Deficiency/pp [Physiopathology]
+ Young Adult
+Keyword Heading
+ Bioelectrical Impedance Analysis (BIA)
+ Inflammation.
+ Obesity
+ Phase Angle (PhA)
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated to chronic low-grade metabolic inflammation and hypovitaminosis D. Among extra-skeletal effects, an important role in inflammation has been described for vitamin D (25(OH)D). Phase angle (PhA) is a bioelectrical impedance analysis (BIA) parameter that represents an indicator of cellular health in chronic inflammatory states. However, it is still unknown whether a low 25(OH)D levels might correlate with PhA in obesity. Considering the lack of evidence correlating the 25(OH)D levels with PhA in obesity, the aim of this study was to investigate their possible relationship in a group of patients with obesity stratified according to body mass index (BMI) categories. Four hundred and fifty-five adult subjects (219 males and 236 females; 36 +/- 11 years) were enrolled. Body composition, including PhA, was assessed using a BIA phase-sensitive system. Serum levels of 25(OH)D was determined by a direct competitive chemiluminescence immunoassay. Most of the participants were affected by grade III obesity (24%) and had 25(OH)D deficiency (67%). Subjects with 25(OH)D deficiency had highest BMI (p < 0.001). Stratifying the sample population according to the BMI classes, 25(OH)D levels decreased significantly along with the increase in BMI (p < 0.001), with the lowest 25(OH)D levels in the class III obesity. In addition, stratifying the sample population according to 25(OH)D categories, BMI and fat mass (FM) decreased, while PhA increased significantly along with the 25(OH)D categories (p < 0.001). The 25(OH)D levels showed significant positive associations with PhA (r = -0.59, p < 0.001), and this association remained significant also after adjusting for BMI and FM (r = 0.60, p < 0.001). The lowest values of PhA were significantly associated with the severity of obesity (OR 0.3, p < 0.001) and of 25(OH)D deficiency (OR 0.2, p < 0.001). To compare the relative predictive power of body composition parameters associated with the 25(OH)D levels, we performed a multiple linear regression analysis. The most sensitive and specific cut-off for 25(OH)D levels to predict the PhA above the median was >14 ng/mL (p < 0.001). In conclusion, we provided preliminary insights into a novel link between 25(OH)D levels and PhA in the setting of obesity. This association uncovered a new potential usefulness of PhA as expression of cell membrane integrity and predictor of inflammation in low 25(OH)D status that might help in identifying high-risk patients with obesity who could benefit from careful 25(OH)D supplementation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1406-16-2 (Vitamin D). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11081747
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Barrea&issn=2072-6643&title=Nutrients&atitle=Phase+Angle%3A+A+Possible+Biomarker+to+Quantify+Inflammation+in+Subjects+with+Obesity+and+25%28OH%29D+Deficiency.&volume=11&issue=8&spage=&epage=&date=2019&doi=10.3390%2Fnu11081747&pmid=31362440&sid=OVID:medline
+
+<1553>
+Unique Identifier
+ 31361296
+Title
+ Plasma phospholipid fatty acid patterns are associated with adiposity and the metabolic syndrome in black South Africans: a cross-sectional study.
+Source
+ Cardiovascular Journal of Africa. 30(4):228-238, 2019 Jul/Aug 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ojwang AA; Kruger HS; Zec M; Ricci C; Pieters M; Kruger IM; Wentzel-Viljoen E; Smuts CM
+Authors Full Name
+ Ojwang, Alice Achieng; Kruger, Herculina Salome; Zec, Manja; Ricci, Cristian; Pieters, Marlien; Kruger, Iolanthe Marike; Wentzel-Viljoen, Edelweiss; Smuts, Cornelius Mattheus.
+Institution
+ Ojwang, Alice Achieng. Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa. Email: ojwangaa@gmail.com.
+ Kruger, Herculina Salome. Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa; Medical Research Council Hypertension and Cardiovascular Disease Research Unit, North-West University, Potchefstroom, South Africa.
+ Zec, Manja. Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa; Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Serbia.
+ Ricci, Cristian. Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.
+ Pieters, Marlien. Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.
+ Kruger, Iolanthe Marike. Africa Unit for Transdisciplinary Health Research, North- West University, Potchefstroom, South Africa.
+ Wentzel-Viljoen, Edelweiss. Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.
+ Smuts, Cornelius Mattheus. Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ *Adiposity/eh [Ethnology]
+ Biomarkers/bl [Blood]
+ *Black People
+ Cross-Sectional Studies
+ *Fatty Acids/bl [Blood]
+ Female
+ Humans
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/eh [Ethnology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/eh [Ethnology]
+ Obesity/pp [Physiopathology]
+ *Phospholipids/bl [Blood]
+ Protective Factors
+ Risk Assessment
+ Risk Factors
+ South Africa/ep [Epidemiology]
+Keyword Heading
+ adiposity
+ dietary fatty acid patterns
+ metabolic syndrome
+ phospholipid fatty acid patterns
+ waist:height ratio
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Diets rich in n-6 polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFA) have been associated with increased risk of obesity and the metabolic syndrome (MetS), but the evidence is inconsistent, whereas diets high in n-3 long-chain (LC) -PUFAs are associated with lower risk. There is limited information about the association of plasma phospholipid fatty acids (FAs) with obesity and the MetS among black South Africans.
+
+ OBJECTIVE: To investigate the association of dietary FAs and plasma phospholipid FA patterns, respectively, with measures of adiposity (body mass index, waist circumference, waist-to-height ratio) and the MetS in black South Africans.
+
+ METHODS: Factor analysis was used to identify FA patterns from 11 dietary FAs and 26 individual plasma phospholipid FAs. Cross-sectional association of the identified patterns with measures of adiposity and the MetS was investigated. A random sample of 711 black South African adults aged 30 to 70 years (273 men, 438 women) from the North West Province was selected from the South African leg of the Prospective Urban and Rural Epidemiology (PURE) study. Sequential regression models adjusted for confounders were applied to investigate the association between dietary FAs and plasma phospholipid FA patterns with measures of adiposity and the MetS.
+
+ RESULTS: Two patterns were derived from dietary FAs and six patterns from plasma phospholipid FAs that explained the cumulative variance of 89 and 73%, respectively. The association of FA patterns with adiposity and the MetS was weaker for dietary FA patterns than for plasma phospholipid FA patterns. The plasma phospholipid FA pattern with high loadings of saturated FAs (high-Satfat) and another with high loadings of n-3 very-long-chain PUFAs (n-3 VLC-PUFAs) were positively associated with measures of adiposity and the MetS, while patterns with positive loadings of LC monounsaturated fatty acids (n-9 LC-MUFA) and a positive loading of n-3 essential FAs (n-3 EFA) showed inverse associations with the MetS and some measures of adiposity.
+
+ CONCLUSION: The n-9 LC-MUFA and n-3 EFA patterns seemed to provide possible protective associations with adiposity and the MetS, whereas the high-Satfat and n-3 VLC-PUFA patterns were associated with adiposity and the MetS in our study participants. The results are reflective of the metabolic difference between overweight and obese compared to lean individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids). 0 (Phospholipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.5830%2fCVJA-2019-026
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ojwang&issn=1015-9657&title=Cardiovascular+Journal+of+Africa&atitle=Plasma+phospholipid+fatty+acid+patterns+are+associated+with+adiposity+and+the+metabolic+syndrome+in+black+South+Africans%3A+a+cross-sectional+study.&volume=30&issue=4&spage=228&epage=238&date=2019&doi=10.5830%2FCVJA-2019-026&pmid=31361296&sid=OVID:medline
+
+<1554>
+Unique Identifier
+ 31358094
+Title
+ Effects of Recombinant Irisin on Body Mass Index, Serum Insulin, Luteinizing Hormone and Testosterone Levels in Obese Female BALB/c Mice.
+Source
+ Jcpsp, Journal of the College of Physicians & Surgeons - Pakistan. 29(8):736-740, 2019 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Majeed S; Shafi R; Moin H; Ashraf I; Irshad K; Liaquat A
+Authors Full Name
+ Majeed, Sadaf; Shafi, Riffat; Moin, Hira; Ashraf, Ifra; Irshad, Khurram; Liaquat, Afrose.
+Institution
+ Majeed, Sadaf. Department of Physiology, Shifa College of Medicine, Islamabad, Pakistan.
+ Shafi, Riffat. Department of Physiology, Shifa College of Medicine, Islamabad, Pakistan.
+ Moin, Hira. Department of Physiology, Shifa College of Medicine, Islamabad, Pakistan.
+ Ashraf, Ifra. Department of Physiology, Shifa College of Medicine, Islamabad, Pakistan.
+ Irshad, Khurram. Department of Physiology, Shifa College of Medicine, Islamabad, Pakistan.
+ Liaquat, Afrose. Department of Biochemistry, Shifa College of Medicine, Islamabad, Pakistan.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Female
+ *Fibronectins/pd [Pharmacology]
+ Insulin/bl [Blood]
+ Luteinizing Hormone/bl [Blood]
+ Mice
+ Mice, Inbred BALB C
+ *Obesity/bl [Blood]
+ Testosterone/bl [Blood]
+Abstract
+ OBJECTIVE: To determine the effects of recombinant irisin on body mass index (BMI), serum insulin, luteinizing hormone (LH) and testosterone levels, and to correlate the serum insulin levels with serum luteinizing hormone and testosterone levels and to correlate the body mass index with serum insulin levels in obese female BALB/c mice.
+
+ STUDY DESIGN: Laboratory-based experimental study.
+
+ PLACE AND DURATION OF STUDY: Department of Physiology, Shifa College of Medicine, Islamabad in collaboration with Research Laboratory of Shifa College of Medicine, National Institute of Health (NIH) and Reproductive Physiology Laboratory, Quaid-e-Azam University, Islamabad, from March 2015 to September 2016.
+
+ METHODOLOGY: Ninety female BALB/c mice were divided into three equal groups. Group A which was the control group was fed with normal chow diet. Group B and Group C were fed with high fat-high sucrose (HF-HS) diet for five weeks to induce obesity. After four weeks group C was divided into two subgroups. Group C-low dose (LD) was injected with low dose irisin and group C-High dose (HD) was injected with high dose irisin for one week. After five weeks, the BMI, serum insulin, LH and testosterone levels were measured in all the groups. Data was analysed by SPSS version 21. P-value of <0.05 was considered significant.
+
+ RESULTS: Group B showed statistically significant elevation in BMI, serum insulin, LH and testosterone levels as compared to Group A (p <0.001, <0.001, 0.007 and 0.014, respectively). Group C-HD showed statistically significant decrease in BMI, serum insulin, and LH as compared to Group B (p <0.001, 0.013 and 0.028, respectively). Serum testosterone level was also decreased in group C-HD as compared to Group B, however the difference was not significant.
+
+ CONCLUSION: Obesity increases the serum insulin, LH and testosterone and irisin significantly lowers the elevated BMI, serum insulin and LH levels in female BALB/c mice. It also lowers the elevated testosterone levels, but not significantly.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FNDC5 protein, mouse). 0 (Fibronectins). 0 (Insulin). 3XMK78S47O (Testosterone). 9002-67-9 (Luteinizing Hormone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.29271%2fjcpsp.2019.08.736
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Majeed&issn=1022-386X&title=Jcpsp%2C+Journal+of+the+College+of+Physicians+%26+Surgeons+-+Pakistan&atitle=Effects+of+Recombinant+Irisin+on+Body+Mass+Index%2C+Serum+Insulin%2C+Luteinizing+Hormone+and+Testosterone+Levels+in+Obese+Female+BALB%2Fc+Mice.&volume=29&issue=8&spage=736&epage=740&date=2019&doi=10.29271%2Fjcpsp.2019.08.736&pmid=31358094&sid=OVID:medline
+
+<1555>
+Unique Identifier
+ 31354986
+Title
+ Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease.
+Source
+ Journal of Obesity. 2019:3139278, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Garofallo SB; Portal VL; Markoski MM; Dias LD; de Quadrosa AS; Marcadenti A
+Author NameID
+ Markoski, Melissa Medeiros; ORCID: https://orcid.org/0000-0003-2982-5850
+ Dias, Lucinara Dadda; ORCID: https://orcid.org/0000-0002-2490-0412
+ Marcadenti, Aline; ORCID: https://orcid.org/0000-0003-1994-4610
+Authors Full Name
+ Garofallo, Silvia Bueno; Portal, Vera Lucia; Markoski, Melissa Medeiros; Dias, Lucinara Dadda; de Quadrosa, Alexandre Schaan; Marcadenti, Aline.
+Institution
+ Garofallo, Silvia Bueno. Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil.
+ Portal, Vera Lucia. Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil.
+ Markoski, Melissa Medeiros. Graduate Program in Nutrition Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Sarmento Leite Street, 245, Porto Alegre, Rio Grande do Sul 90050-170, Brazil.
+ Dias, Lucinara Dadda. Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil.
+ de Quadrosa, Alexandre Schaan. Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil.
+ Marcadenti, Aline. Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, Brazil.
+ Marcadenti, Aline. Graduate Program in Nutrition Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Sarmento Leite Street, 245, Porto Alegre, Rio Grande do Sul 90050-170, Brazil.
+ Marcadenti, Aline. Institute of Research,Coracao Hospital (HCor), Abilio Soares Street, 250, Sao Paulo, Sao Paulo 04004-05, Brazil.
+MeSH Subject Headings
+ Adiposity
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Coronary Artery Disease/bl [Blood]
+ Coronary Artery Disease/pp [Physiopathology]
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/pp [Physiopathology]
+ Male
+ Middle Aged
+ Monocytes/cl [Classification]
+ *Monocytes/ph [Physiology]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/pp [Physiopathology]
+Abstract
+ Background: Recruitment of monocytes and low-grade inflammation process are both involved in obesity and in atherosclerosis. Thus, the aim of this study was to evaluate the correlation among indicators of adiposity, monocyte subtypes, and inflammatory markers in patients with stable coronary artery disease (CAD).
+
+ Methods: This was a cross-sectional study including 97 patients with stable CAD aged >40 years. Traditional anthropometric indicators of adiposity (body mass index (BMI); waist, hip, and neck circumferences; and waist-hip ratio) and nontraditional anthropometric indicators of adiposity (lipid accumulation product index (LAP), visceral adiposity index (VAI), and deep-abdominal-adipose-tissue index (DAAT)) were determined. Immunoprecipitation, turbidimetry, coagulometric method, and CBA were used for the evaluation of inflammatory markers (hs-CRP, IL-2, IL-4, IL-6, IL-10, and INF-gamma). Monocyte subtypes were identified by flow cytometry and defined as CD14++ CD16- (Mon1), CD14++ CD16+ (Mon2), and CD14+ CD16++ (Mon3). Pearson's correlation coefficient and adjusted partial correlation were calculated.
+
+ Results: Monocyte subtypes were correlated with inflammation regardless of nutritional status according to BMI. In overweight individuals, LAP was correlated with IL-4 and fibrinogen (P < 0.01 and P < 0.05, respectively) and VAI with IL-4 (P < 0.05). In obese patients, the BMI, waist, neck, and hip circumferences, and DAAT were correlated with IL-6 (P < 0.05), regardless of age and sex. The hip circumference was correlated positively with Mon1 (r = 0.40, P = 0.007) and negatively with Mon3 (r = -0.35, P = 0.02) in obese subjects.
+
+ Conclusion: Monocyte subtypes are correlated with inflammation in patients with stable CAD independently of BMI, whereas traditional and nontraditional indicators of adiposity are correlated differently with inflammatory markers and monocytes, according to the nutritional status.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f3139278
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Garofallo&issn=2090-0708&title=Journal+of+Obesity&atitle=Correlations+between+Traditional+and+Nontraditional+Indicators+of+Adiposity%2C+Inflammation%2C+and+Monocyte+Subtypes+in+Patients+with+Stable+Coronary+Artery+Disease.&volume=2019&issue=&spage=3139278&epage=&date=2019&doi=10.1155%2F2019%2F3139278&pmid=31354986&sid=OVID:medline
+
+<1556>
+Unique Identifier
+ 31345191
+Title
+ Evaluation and refinement of the PRESTARt tool for identifying 12-14 year olds at high lifetime risk of developing type 2 diabetes compared to a clinicians assessment of risk: a cross-sectional study.
+Source
+ BMC Endocrine Disorders. 19(1):79, 2019 Jul 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gray LJ; Brady EM; Albaina O; Edwardson CL; Harrington D; Khunti K; Miksza J; Raposo JF; Smith E; Vazeou A; Vergara I; Weihrauch-Bluher S; Davies MJ
+Corporate Author
+ PRE-STARt Collaborative
+Authors Full Name
+ Gray, Laura J; Brady, Emer M; Albaina, Olatz; Edwardson, Charlotte L; Harrington, Deirdre; Khunti, Kamlesh; Miksza, Joanne; Raposo, Joao Filipe; Smith, Ellesha; Vazeou, Andriani; Vergara, Itziar; Weihrauch-Bluher, Susann; Davies, Melanie J.
+Institution
+ Gray, Laura J. Department of Health Sciences, College of Life Sciences, University of Leicester, George Davies Centre, University Road, Leicester, LE1 7RH, UK. lg48@leicester.ac.uk.
+ Brady, Emer M. Leicester Diabetes Centre, University Hospitals of Leicester, Leicester, LE5 4PW, UK.
+ Albaina, Olatz. Kronikgune, Torre del BEC (Bilbao Exhibition Centre), Ronda de Azkue, 1, 48902, Barakaldo, Bizkaia, Spain.
+ Edwardson, Charlotte L. Diabetes Research Centre, University of Leicester, Leicester, LE5 4PW, UK.
+ Harrington, Deirdre. Diabetes Research Centre, University of Leicester, Leicester, LE5 4PW, UK.
+ Khunti, Kamlesh. Diabetes Research Centre, University of Leicester, Leicester, LE5 4PW, UK.
+ Miksza, Joanne. Diabetes Research Centre, University of Leicester, Leicester, LE5 4PW, UK.
+ Raposo, Joao Filipe. Associacao Protectora dos Diabeticas de Portugal, Lisboa, Portugal.
+ Smith, Ellesha. Department of Health Sciences, College of Life Sciences, University of Leicester, George Davies Centre, University Road, Leicester, LE1 7RH, UK.
+ Vazeou, Andriani. Diabetes Center, Department of Pediatrics, P&A Kyriakou Children's Hospital, Athens, Greece.
+ Vergara, Itziar. Kronikgune, Torre del BEC (Bilbao Exhibition Centre), Ronda de Azkue, 1, 48902, Barakaldo, Bizkaia, Spain.
+ Vergara, Itziar. Unidad de Investigacion APOSIs Gipuzkoa, Osakidetza, Instituto Biodonostia, San Sebastian, Spain.
+ Vergara, Itziar. Red de Investigacion en Servicios de Salud y Cronicidad REDISSEC, San Sebastian, Spain.
+ Weihrauch-Bluher, Susann. Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany.
+ Weihrauch-Bluher, Susann. Department of Pediatrics/ Pediatric Endorinology I, University Hospital of Halle/S, Halle, Germany.
+ Davies, Melanie J. Leicester Diabetes Centre, University Hospitals of Leicester, Leicester, LE5 4PW, UK.
+ Davies, Melanie J. Diabetes Research Centre, University of Leicester, Leicester, LE5 4PW, UK.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/an [Analysis]
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Europe/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ Male
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prognosis
+ *Risk Assessment/mt [Methods]
+ Risk Factors
+ *Waist Circumference
+Keyword Heading
+ Adolescent
+ Diabetes mellitus, type 2
+ Europe
+ Obesity
+ Risk factors
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Traditionally Type 2 Diabetes Mellitus (T2DM) was associated with older age, but is now being increasingly diagnosed in younger populations due to the increasing prevalence of obesity and inactivity. We aimed to evaluate whether a tool developed for community use to identify adolescents at high lifetime risk of developing T2DM agreed with a risk assessment conducted by a clinician using data collected from five European countries. We also assessed whether the tool could be simplified.
+
+ METHODS: To evaluate the tool we collected data from 636 adolescents aged 12-14 years from five European countries. Each participant's data were then assessed by two clinicians independently, who judged each participant to be at either low or high risk of developing T2DM in their lifetime. This was used as the gold standard to which the tool was evaluated and refined.
+
+ RESULTS: The refined tool categorised adolescents at high risk if they were overweight/obese and had at least one other risk factor (High waist circumference, family history of diabetes, parental obesity, not breast fed, high sugar intake, high screen time, low physical activity and low fruit and vegetable intake). Of those found to be at high risk by the clinicians, 93% were also deemed high risk by the tool. The specificity shows that 67% of those deemed at low risk by the clinicians were also found to be a low risk by the tool.
+
+ CONCLUSIONS: We have evaluated a tool for identifying adolescents with risk factors associated with the development of T2DM in the future. Future work to externally validate the tool using prospective data including T2DM incidence is required.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Evaluation Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0410-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gray&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Evaluation+and+refinement+of+the+PRESTARt+tool+for+identifying+12-14+year+olds+at+high+lifetime+risk+of+developing+type+2+diabetes+compared+to+a+clinicians+assessment+of+risk%3A+a+cross-sectional+study.&volume=19&issue=1&spage=79&epage=&date=2019&doi=10.1186%2Fs12902-019-0410-3&pmid=31345191&sid=OVID:medline
+
+<1557>
+Unique Identifier
+ 31343124
+Title
+ Pharmacokinetic and Pharmacodynamic Effects of Oral CXA-10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects.
+Source
+ Clinical and translational science. 12(6):667-676, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Garner RM; Mould DR; Chieffo C; Jorkasky DK
+Authors Full Name
+ Garner, Rachel M; Mould, Diane R; Chieffo, Carla; Jorkasky, Diane K.
+Institution
+ Garner, Rachel M. Complexa, Inc., Berwyn, Pennsylvania, USA.
+ Mould, Diane R. Projections Research Inc, Phoenixville, Pennsylvania, USA.
+ Chieffo, Carla. Complexa, Inc., Berwyn, Pennsylvania, USA.
+ Jorkasky, Diane K. Complexa, Inc., Berwyn, Pennsylvania, USA.
+MeSH Subject Headings
+ Abdominal Pain/ci [Chemically Induced]
+ Abdominal Pain/ep [Epidemiology]
+ Administration, Oral
+ Adult
+ Area Under Curve
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Diarrhea/ci [Chemically Induced]
+ Diarrhea/ep [Epidemiology]
+ Dose-Response Relationship, Drug
+ Double-Blind Method
+ Drug Administration Schedule
+ Fasting
+ Female
+ Healthy Volunteers
+ Humans
+ Incidence
+ Inflammation/bl [Blood]
+ *Inflammation/dt [Drug Therapy]
+ Inflammation/im [Immunology]
+ Inflammation/me [Metabolism]
+ *Lipid Metabolism/de [Drug Effects]
+ Male
+ Middle Aged
+ Nausea/ci [Chemically Induced]
+ Nausea/ep [Epidemiology]
+ *Nitro Compounds/ad [Administration & Dosage]
+ Nitro Compounds/ae [Adverse Effects]
+ Nitro Compounds/pk [Pharmacokinetics]
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Obesity/im [Immunology]
+ Obesity/me [Metabolism]
+ *Oleic Acids/ad [Administration & Dosage]
+ Oleic Acids/ae [Adverse Effects]
+ Oleic Acids/pk [Pharmacokinetics]
+ Postprandial Period
+ Young Adult
+Abstract
+ 10-nitro-9(E)-octadec-9-enoic acid (CXA-10), a novel nitro fatty acid compound, demonstrates potential as a therapeutic agent in multiple disease indications in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles. Phase I studies were conducted in healthy and obese subjects to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of oral CXA-10 after single and multiple doses in the fed and fasted states that would confirm the mechanisms of action of CXA-10. After single and multiple ascending doses, CXA-10 demonstrated dose-proportional increases in plasma exposure. CXA-10 decreased levels of biomarkers associated with altered inflammation and metabolic stress observed from nonclinical studies. In CXA-10-202, a consistent decrease from baseline was observed with CXA-10 150 mg dose, but not 25 or 450 mg doses, for biomarkers of altered inflammation and metabolic dysfunction, including leptin, triglycerides, cholesterol, MCP-1, and IL-6. In CXA-10-203, after coadministration with CXA-10, geometric mean peak plasma concentration (Cmax ) and area under the plasma concentration-time curve from time point 0 to the end of the dosing interval (AUC0-t ) decreased 20% and 25% for pravastatin, increased 10% and 25% for simvastatin, and decreased 20% and 5% for ezetimibe. These findings are consistent with the pharmacological effects of CXA-10. Adverse events (AEs) were dose-related, and the most frequently reported AEs (>10% of subjects) were diarrhea, abdominal pain, and nausea. CXA-10 was safe and well-tolerated with no clinically significant abnormalities reported on physical examination, vital signs, clinical laboratory evaluations, or electrocardiographic evaluation. Phase II studies are underway in patients with focal segmental glomerulosclerosis and pulmonary arterial hypertension to investigate the efficacy and tolerability of CXA-10 75-300 mg once daily. Copyright © 2019 Complexa, Inc. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Nitro Compounds). 0 (Oleic Acids). 1N19AGY57Y (CXA-10).
+Publication Type
+ Clinical Trial, Phase I. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fcts.12672
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Garner&issn=1752-8054&title=Clinical+and+translational+science&atitle=Pharmacokinetic+and+Pharmacodynamic+Effects+of+Oral+CXA-10%2C+a+Nitro+Fatty+Acid%2C+After+Single+and+Multiple+Ascending+Doses+in+Healthy+and+Obese+Subjects.&volume=12&issue=6&spage=667&epage=676&date=2019&doi=10.1111%2Fcts.12672&pmid=31343124&sid=OVID:medline
+
+<1558>
+Unique Identifier
+ 31341005
+Title
+ Measures of obesity are associated with MRI markers of brain aging: The Northern Manhattan Study.
+Source
+ Neurology. 93(8):e791-e803, 2019 08 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Caunca MR; Gardener H; Simonetto M; Cheung YK; Alperin N; Yoshita M; DeCarli C; Elkind MSV; Sacco RL; Wright CB; Rundek T
+Author NameID
+ Yoshita, Mitsuhiro; ORCID: https://orcid.org/0000-0001-5979-8385
+Authors Full Name
+ Caunca, Michelle R; Gardener, Hannah; Simonetto, Marialaura; Cheung, Ying Kuen; Alperin, Noam; Yoshita, Mitsuhiro; DeCarli, Charles; Elkind, Mitchell S V; Sacco, Ralph L; Wright, Clinton B; Rundek, Tatjana.
+Institution
+ Caunca, Michelle R. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Gardener, Hannah. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Simonetto, Marialaura. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Cheung, Ying Kuen. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Alperin, Noam. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Yoshita, Mitsuhiro. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ DeCarli, Charles. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Elkind, Mitchell S V. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Sacco, Ralph L. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Wright, Clinton B. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
+ Rundek, Tatjana. From the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD. trundek@med.miami.edu.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Aged
+ *Aging/bl [Blood]
+ *Aging/pa [Pathology]
+ Atrophy/pa [Pathology]
+ Biomarkers/bl [Blood]
+ Body Size
+ *Brain/pa [Pathology]
+ Brain Infarction/co [Complications]
+ Brain Infarction/pa [Pathology]
+ Female
+ Humans
+ Magnetic Resonance Imaging
+ Male
+ Middle Aged
+ Neuroimaging
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/pa [Pathology]
+ White Matter/pa [Pathology]
+Abstract
+ OBJECTIVE: To examine associations between measures of obesity in middle to early-old age with later-life MRI markers of brain aging.
+
+ METHODS: We analyzed data from the Northern Manhattan MRI Sub-Study (n = 1,289). Our exposures of interest were body mass index (BMI), waist circumference (WC), waist-to-hip ratio, and plasma adiponectin levels. Our outcomes of interest were total cerebral volume (TCV), cortical thickness, white matter hyperintensity volume (WMHV), and subclinical brain infarcts (SBI). Using multivariable linear and logistic regression models adjusted for sociodemographics, health behaviors, and vascular risk factors, we estimated beta coefficients (or odds ratios) and 95% confidence intervals (CIs) and tested interactions with age, sex, and race/ethnicity.
+
+ RESULTS: On average at baseline, participants were aged 64 years and had 10 years of education; 60% were women and 66% were Caribbean Hispanic. The mean (SD) time lag between baseline and MRI was 6 (3) years. Greater BMI and WC were significantly associated with thinner cortices (BMI beta [95% CI] -0.089 [-0.153, -0.025], WC beta [95% CI] -0.103 [-0.169, -0.037]) in fully adjusted models. Similarly, compared to those with BMI <25, obese participants (BMI >=30) exhibited smaller cortical thickness (beta [95% CI] -0.207 [-0.374, -0.041]). These associations were particularly evident for those aged <65 years. Similar but weaker associations were observed for TCV. Most associations with WMHV and SBI did not reach statistical significance.
+
+ CONCLUSIONS: Adiposity in early-old age is related to reduced global gray matter later in life in this diverse sample. Future studies are warranted to elucidate causal relationships and explore region-specific associations. Copyright © 2019 American Academy of Neurology.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1212%2fWNL.0000000000007966
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Caunca&issn=0028-3878&title=Neurology&atitle=Measures+of+obesity+are+associated+with+MRI+markers+of+brain+aging%3A+The+Northern+Manhattan+Study.&volume=93&issue=8&spage=e791&epage=e803&date=2019&doi=10.1212%2FWNL.0000000000007966&pmid=31341005&sid=OVID:medline
+
+<1559>
+Unique Identifier
+ 31340583
+Title
+ Wheat Flour, Enriched with gamma-Oryzanol, Phytosterol, and Ferulic Acid, Alleviates Lipid and Glucose Metabolism in High-Fat-Fructose-Fed Rats.
+Source
+ Nutrients. 11(7), 2019 Jul 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Guo XX; Zeng Z; Qian YZ; Qiu J; Wang K; Wang Y; Ji BP; Zhou F
+Author NameID
+ Wang, Kai; ORCID: https://orcid.org/0000-0003-0553-5293
+ Zhou, Feng; ORCID: https://orcid.org/0000-0003-0665-8076
+Authors Full Name
+ Guo, Xiao-Xuan; Zeng, Zhu; Qian, Yong-Zhong; Qiu, Jing; Wang, Kai; Wang, Yong; Ji, Bao-Ping; Zhou, Feng.
+Institution
+ Guo, Xiao-Xuan. Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
+ Guo, Xiao-Xuan. Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
+ Zeng, Zhu. State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Biotechnology, Southwest University, Chongqing 400715, China.
+ Qian, Yong-Zhong. Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
+ Qiu, Jing. Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
+ Wang, Kai. Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.
+ Wang, Yong. Academy of State Administration of Grain, Beijing 100037, China.
+ Ji, Bao-Ping. Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
+ Zhou, Feng. Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. zf@cau.edu.cn.
+MeSH Subject Headings
+ *Animal Feed
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Coumaric Acids/ad [Administration & Dosage]
+ Coumaric Acids/me [Metabolism]
+ Dietary Sugars
+ Disease Models, Animal
+ *Flour
+ *Food, Fortified
+ Fructose
+ Hep G2 Cells
+ Humans
+ *Lipids/bl [Blood]
+ Male
+ Metabolic Diseases/bl [Blood]
+ Metabolic Diseases/et [Etiology]
+ *Metabolic Diseases/pc [Prevention & Control]
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ *Obesity/pc [Prevention & Control]
+ *Phenylpropionates/ad [Administration & Dosage]
+ Phenylpropionates/me [Metabolism]
+ *Phytosterols/ad [Administration & Dosage]
+ Phytosterols/me [Metabolism]
+ Rats, Sprague-Dawley
+ Signal Transduction
+ *Triticum
+Keyword Heading
+ ferulic acid
+ lipid/glucose metabolism
+ phytosterol
+ wheat flour
+ gamma-oryzanol
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ (1) Background: Modern dietary patterns with a high intake of fat and fructose, as well as refined carbohydrates, closely relate to lipid/glucose metabolic disorders. The main objective of this study is to provide new thoughts in designing functional food with some lipid/glucose metabolism regulating effects for obese people. (2) Methods: The alleviating abilities of gamma-oryzanol, phytosterol or ferulic acid-enriched wheat flour on lipid/glucose metabolic dysfunction were evaluated in male SD rats induced by a high-fat-fructose diet. The underlying mechanisms were clarified using western blot. (3) Results: In an in vitro cell model, gamma-oryzanol, phytosterol and ferulic acid regulate lipid/glucose metabolism by increasing the phosphorylation of AMPK and Akt, and PI3K expression, as well as decreasing expressions of DGAT1 and SCD. The in vivo study shows that ferulic acid and gamma-oryzanol-enriched flours are beneficial for managing body weight, improving glucose metabolism, hyperlipidemia and hepatic lipid accumulation. Phytosterol-enriched flour exerted remarkable effects in regulating hyperinsulinemia, insulin resistance and hyperuricemia. Western blot analysis of proteins from liver samples reveals that these enriched flours alleviated hepatic lipid accumulation and insulin resistance through their elevation in the phosphorylation of AMPK and Akt. (4) Conclusions: Our study indicates that these enriched flours can serve as a health-promoting functional food to regulate obesity-related lipid/glucose metabolic dysfunction in rats.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Coumaric Acids). 0 (Dietary Sugars). 0 (Lipids). 0 (Phenylpropionates). 0 (Phytosterols). 30237-26-4 (Fructose). AVM951ZWST (ferulic acid). SST9XCL51M (gamma-oryzanol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11071697
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Guo&issn=2072-6643&title=Nutrients&atitle=Wheat+Flour%2C+Enriched+with+gamma-Oryzanol%2C+Phytosterol%2C+and+Ferulic+Acid%2C+Alleviates+Lipid+and+Glucose+Metabolism+in+High-Fat-Fructose-Fed+Rats.&volume=11&issue=7&spage=&epage=&date=2019&doi=10.3390%2Fnu11071697&pmid=31340583&sid=OVID:medline
+
+<1560>
+Unique Identifier
+ 31340493
+Title
+ Life Style Intervention Improves Retinopathy Status-The Finnish Diabetes Prevention Study.
+Source
+ Nutrients. 11(7), 2019 Jul 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aro A; Kauppinen A; Kivinen N; Selander T; Kinnunen K; Tuomilehto J; Keinanen-Kiukaanniemi S; Lindstrom J; Uusitupa M; Kaarniranta K
+Author NameID
+ Kauppinen, A; ORCID: https://orcid.org/0000-0001-8254-0200
+ Uusitupa, M; ORCID: https://orcid.org/0000-0001-6052-2001
+Authors Full Name
+ Aro, A; Kauppinen, A; Kivinen, N; Selander, T; Kinnunen, K; Tuomilehto, J; Keinanen-Kiukaanniemi, S; Lindstrom, J; Uusitupa, M; Kaarniranta, K.
+Institution
+ Aro, A. Department of Ophthalmology, Karelia Central Hospital, 80210 Joensuu, Finland.
+ Kauppinen, A. School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland.
+ Kivinen, N. Department of Ophthalmology, Kuopio University Hospital, 70029 Kuopio, Finland.
+ Selander, T. Research Service Unit, Kuopio University Hospital, 70029 Kuopio, Finland.
+ Kinnunen, K. Department of Ophthalmology, Kuopio University Hospital, 70029 Kuopio, Finland.
+ Tuomilehto, J. Dasman Diabetes Institute, 15462 Dasman, Kuwai.
+ Keinanen-Kiukaanniemi, S. Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland.
+ Lindstrom, J. Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland.
+ Uusitupa, M. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.
+ Kaarniranta, K. Department of Ophthalmology, University of Eastern Finland and Kuopio University Hospital, 70029 Kuopio, Finland. kai.kaarniranta@uef.fi.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Diet, Healthy
+ Exercise
+ Female
+ Finland
+ Glucose Intolerance/bl [Blood]
+ Glucose Intolerance/co [Complications]
+ Glucose Intolerance/di [Diagnosis]
+ *Glucose Intolerance/th [Therapy]
+ *Healthy Lifestyle
+ Humans
+ Male
+ Microaneurysm/bl [Blood]
+ Microaneurysm/di [Diagnosis]
+ Microaneurysm/et [Etiology]
+ *Microaneurysm/pc [Prevention & Control]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity/th [Therapy]
+ Protective Factors
+ Retinal Diseases/bl [Blood]
+ Retinal Diseases/di [Diagnosis]
+ Retinal Diseases/et [Etiology]
+ *Retinal Diseases/pc [Prevention & Control]
+ Risk Assessment
+ Risk Factors
+ *Risk Reduction Behavior
+ Time Factors
+ Treatment Outcome
+ Triglycerides/bl [Blood]
+ Weight Loss
+Keyword Heading
+ diabetes
+ intervention
+ retinopathy
+ triglycerides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The aim of the study was to find out whether participation in earlier intervention had an effect on the occurrence of retinopathy in study participants. We also examined risk factors (age, sex, weight, fasting and 2 h glucose, fasting insulin, blood pressure, serum lipids) for early retinal changes. The study included 522 individuals (mean 55 years old, range 40-64 years) with impaired glucose tolerance who were randomized into intervention (weight loss, healthy diet, and physical activity, N = 265) and control groups (N = 257). Intervention lasted for median of four years in 1993-2000, after which annual follow-up visits at study clinics were conducted. In the years 2002-2006 (at least five years after stopping intervention), fundus photography was offered for all study participants in four of five study clinics. Photographs were assessed by two experienced ophthalmologists (A.A. and K.K.), masked for the group assignment. After exclusion of poor quality photographs, the data of 211 individuals (N = 113 for intervention and N = 98 for control group) were included in the present study. The occurrence of microaneurysms was significantly higher in the control (37/98, 38%) than in the intervention group (27/113, 24%; p = 0.029). In the model, including age, sex, diabetes diagnosis before the retinal assessment, body mass index (BMI), and treatment group, the odds ratio for microaneurysms was markedly lower in intervention group (OR 0.52; 0.28-0.97, p = 0.039). The only risk factor that predicted the occurrence of microaneurysms was serum triglycerides at baseline (mean +/- SD 1.9 +/- 0.9 vs. 1.6 +/- 0.7, mmol/L, with and without microaneurysms, respectively, p = 0.003). Triglycerides associated with decreased microaneurysms in regression analysis for age, sex, fasting glucose, and intervention group (OR 1.92, p = 0.018). Lifestyle intervention in overweight and obese individuals with impaired glucose tolerance showed decreased occurrence of retinal microaneurysms. Elevated serum triglycerides were associated to the development of early diabetic microangiopathy.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11071691
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aro&issn=2072-6643&title=Nutrients&atitle=Life+Style+Intervention+Improves+Retinopathy+Status-The+Finnish+Diabetes+Prevention+Study.&volume=11&issue=7&spage=&epage=&date=2019&doi=10.3390%2Fnu11071691&pmid=31340493&sid=OVID:medline
+
+<1561>
+Unique Identifier
+ 31337068
+Title
+ Annexins in Adipose Tissue: Novel Players in Obesity. [Review]
+Source
+ International Journal of Molecular Sciences. 20(14), 2019 Jul 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Grewal T; Enrich C; Rentero C; Buechler C
+Author NameID
+ Enrich, Carlos; ORCID: https://orcid.org/0000-0003-0382-2993
+ Rentero, Carles; ORCID: https://orcid.org/0000-0003-4684-0278
+ Buechler, Christa; ORCID: https://orcid.org/0000-0002-5635-3994
+Authors Full Name
+ Grewal, Thomas; Enrich, Carlos; Rentero, Carles; Buechler, Christa.
+Institution
+ Grewal, Thomas. School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
+ Enrich, Carlos. Department of Biomedicine, Unit of Cell Biology, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
+ Enrich, Carlos. Centre de Recerca Biomedica CELLEX, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
+ Rentero, Carles. Department of Biomedicine, Unit of Cell Biology, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
+ Rentero, Carles. Centre de Recerca Biomedica CELLEX, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
+ Buechler, Christa. Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany. christa.buechler@klinik.uni-regensburg.de.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ *Annexins/ge [Genetics]
+ *Annexins/me [Metabolism]
+ Biomarkers
+ Disease Susceptibility
+ Gene Expression Regulation
+ Glucose/me [Metabolism]
+ Humans
+ Insulin/me [Metabolism]
+ Lipid Metabolism
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+Keyword Heading
+ adiponectin
+ adipose tissue
+ annexins
+ cholesterol
+ glucose homeostasis
+ inflammation
+ insulin
+ lipid metabolism
+ obesity
+ triglycerides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and the associated comorbidities are a growing health threat worldwide. Adipose tissue dysfunction, impaired adipokine activity, and inflammation are central to metabolic diseases related to obesity. In particular, the excess storage of lipids in adipose tissues disturbs cellular homeostasis. Amongst others, organelle function and cell signaling, often related to the altered composition of specialized membrane microdomains (lipid rafts), are affected. Within this context, the conserved family of annexins are well known to associate with membranes in a calcium (Ca2+)- and phospholipid-dependent manner in order to regulate membrane-related events, such as trafficking in endo- and exocytosis and membrane microdomain organization. These multiple activities of annexins are facilitated through their diverse interactions with a plethora of lipids and proteins, often in different cellular locations and with consequences for the activity of receptors, transporters, metabolic enzymes, and signaling complexes. While increasing evidence points at the function of annexins in lipid homeostasis and cell metabolism in various cells and organs, their role in adipose tissue, obesity and related metabolic diseases is still not well understood. Annexin A1 (AnxA1) is a potent pro-resolving mediator affecting the regulation of body weight and metabolic health. Relevant for glucose metabolism and fatty acid uptake in adipose tissue, several studies suggest AnxA2 to contribute to coordinate glucose transporter type 4 (GLUT4) translocation and to associate with the fatty acid transporter CD36. On the other hand, AnxA6 has been linked to the control of adipocyte lipolysis and adiponectin release. In addition, several other annexins are expressed in fat tissues, yet their roles in adipocytes are less well examined. The current review article summarizes studies on the expression of annexins in adipocytes and in obesity. Research efforts investigating the potential role of annexins in fat tissue relevant to health and metabolic disease are discussed.
+Registry Number/Name of Substance
+ 0 (Annexins). 0 (Biomarkers). 0 (Insulin). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20143449
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Grewal&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Annexins+in+Adipose+Tissue%3A+Novel+Players+in+Obesity.&volume=20&issue=14&spage=3449&epage=&date=2019&doi=10.3390%2Fijms20143449&pmid=31337068&sid=OVID:medline
+
+<1562>
+Unique Identifier
+ 31336557
+Title
+ Effect of diet-induced weight loss on cytokeratin-18 levels in overweight and obese patients with liver fibrosis.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):989-994, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Safarian M; Mohammadpour S; Shafiee M; Ganji A; Soleimani A; Nematy M; Bahari A
+Authors Full Name
+ Safarian, Mohammad; Mohammadpour, Sepideh; Shafiee, Mojtaba; Ganji, Azita; Soleimani, Anvar; Nematy, Mohsen; Bahari, Ali.
+Institution
+ Safarian, Mohammad. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Safarianm@mums.ac.ir.
+ Mohammadpour, Sepideh. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Shafiee, Mojtaba. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ganji, Azita. Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Soleimani, Anvar. Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Nematy, Mohsen. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Bahari, Ali. Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ *Diet, Reducing/mt [Methods]
+ Female
+ Follow-Up Studies
+ Humans
+ Iran/ep [Epidemiology]
+ *Keratin-18/bl [Blood]
+ *Liver Cirrhosis/pp [Physiopathology]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ Obesity/ep [Epidemiology]
+ *Overweight/bl [Blood]
+ Overweight/dh [Diet Therapy]
+ Overweight/ep [Epidemiology]
+ Prognosis
+ *Weight Loss
+Keyword Heading
+ Cytokeratin-18
+ Liver fibrosis
+ Obesity
+ Overweight
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Liver biopsy is currently the gold standard test for NAFLD diagnosis and staging but has many drawbacks. In addition, other tools such as transient elastography are limited to specialized research centers. To assess the usefulness of CK-18 as a non-invasive biomarker for detecting therapeutic responses in patients with liver fibrosis.
+
+ MATERIALS AND METHODS: Sixty overweight and obese patients with liver fibrosis were evaluated by a dietitian and given a weight-reducing diet with a calorie deficit of 500-1000kcal/day over a 6-month period. Controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) both were performed at the beginning and at the end of the trial to determine liver steatosis and liver fibrosis, respectively. Serum CK-18 levels were measured by enzyme linked immune sorbent assay (ELISA) at baseline and at 3 and 6 months after intervention.
+
+ RESULTS: Patients experienced a rapid weight loss of -7.6kg (8.5%) during the trial. Among all participants, liver steatosis decreased from 76.5+/-12.2% to 51.8+/-24.4% (baseline to end-point) (p<0.001) and fibrosis score decreased from 9.9+/-3.7 to 7.2+/-2.4 (p<0.001) (a 27.2% decrease). Serum CK-18 levels decreased from 290.2+/-98.1 U/L to 217.6+/-64.8 U/L (p<0.001) (a 25.0% decrease). DELTACK-18 was found to be significantly associated with delta fibrosis score (r=0.25, p=0.05) CONCLUSIONS: This trial showed a significant positive association between changes in CK-18 levels and changes in liver fibrosis over a 6-month dietary intervention. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (KRT18 protein, human). 0 (Keratin-18).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Safarian&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Effect+of+diet-induced+weight+loss+on+cytokeratin-18+levels+in+overweight+and+obese+patients+with+liver+fibrosis.&volume=13&issue=2&spage=989&epage=994&date=2019&doi=10.1016%2Fj.dsx.2019.01.005&pmid=31336557&sid=OVID:medline
+
+<1563>
+Unique Identifier
+ 31336554
+Title
+ Association of body mass index with serum calcium and phosphate levels.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):975-980, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jafari-Giv Z; Avan A; Hamidi F; Tayefi M; Ghazizadeh H; Ghasemi F; Javandoost A; Farjami Z; Mouhebati M; Safarian M; Parizadeh SMR; Saberi-Karimian M; Ferns GA; Ghayour-Mobarhan M
+Authors Full Name
+ Jafari-Giv, Zahra; Avan, Amir; Hamidi, Farshid; Tayefi, Maryam; Ghazizadeh, Hamideh; Ghasemi, Faeze; Javandoost, Ali; Farjami, Zahra; Mouhebati, Mohsen; Safarian, Mohammad; Parizadeh, Seyyed Mohammad Reza; Saberi-Karimian, Maryam; Ferns, Gordon A; Ghayour-Mobarhan, Majid.
+Institution
+ Jafari-Giv, Zahra. Doctor of Veterinary Medicine, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
+ Avan, Amir. Department of Modern Science and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Hamidi, Farshid. Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address: Farshidhamidi@um.ac.ir.
+ Tayefi, Maryam. Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ghazizadeh, Hamideh. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ghasemi, Faeze. Department of Modern Science and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
+ Javandoost, Ali. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Farjami, Zahra. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Mouhebati, Mohsen. Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Safarian, Mohammad. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Parizadeh, Seyyed Mohammad Reza. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Saberi-Karimian, Maryam. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ferns, Gordon A. Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ghayour-Mobarhan, Majid. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghayourm@mums.ac.ir.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Calcium/bl [Blood]
+ Female
+ Follow-Up Studies
+ Humans
+ Kidney Function Tests
+ Liver Function Tests
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ *Phosphates/bl [Blood]
+ Prognosis
+Keyword Heading
+ Body mass index
+ Calcium
+ Fat %
+ Phosphate
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: It has been shown that several environmental and physiological factors can affect on the serum levels of calcium and phosphate. The objective of the present study was explored the relationship between serum calcium and phosphate levels with anthropometric and hematological markers.
+
+ METHODS: 908 subjects were recruited from the Mashhad stroke and heart atherosclerosis disorder (MASHHAD) program. Anthropometric parameters, liver/kidney function tests (e.g., Urea nitrogen, creatinine, urea and uric acid, creatinine, AST, ALT) were determined in all participants. Serum concentrations of calcium and phosphate were measured using Autoanalyzer BT3000P (Pars Azmoon kit, Tehran, Iran). SPSS software was used for statistical analyses.
+
+ RESULTS: We observed that obese subjects had a lower level of serum calcium (p<0.05). Moreover, a relationship was detected between serum phosphate level and different menopausal status (p<0.05). Serum calcium and phosphate did not change by increasing age in the population. Additionally, there was a correlation between lymphocyte count with serum phosphate level (p<0.05). No statistically different were detected for the levels of calcium/phosphate with respect to smoking status, physical activity, lipid profile, liver and renal function markers.
+
+ CONCLUSION: We found an association between serum calcium and BMI as well as with serum phosphate and menopausal status. Copyright © 2019 Diabetes India. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phosphates). SY7Q814VUP (Calcium).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.12.017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jafari-Giv&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+of+body+mass+index+with+serum+calcium+and+phosphate+levels.&volume=13&issue=2&spage=975&epage=980&date=2019&doi=10.1016%2Fj.dsx.2018.12.017&pmid=31336554&sid=OVID:medline
+
+<1564>
+Unique Identifier
+ 31336547
+Title
+ Increased concentration of serum MDA, decreased antioxidants and altered trace elements and macro-minerals are linked to obesity among Bangladeshi population.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):933-938, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adnan MT; Amin MN; Uddin MG; Hussain MS; Sarwar MS; Hossain MK; Uddin SMN; Islam MS
+Authors Full Name
+ Adnan, Md Tarek; Amin, Mohammad Nurul; Uddin, Md Giash; Hussain, Md Saddam; Sarwar, Md Shahid; Hossain, Md Kamrul; Uddin, S M Naim; Islam, Mohammad Safiqul.
+Institution
+ Adnan, Md Tarek. Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh.
+ Amin, Mohammad Nurul. Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh; Department of Pharmacy, Atish Dipankar University of Science and Technology, Uttara, Dhaka, Bangladesh.
+ Uddin, Md Giash. Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh; Department of Pharmacy, Atish Dipankar University of Science and Technology, Uttara, Dhaka, Bangladesh.
+ Hussain, Md Saddam. Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh.
+ Sarwar, Md Shahid. Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh.
+ Hossain, Md Kamrul. Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh.
+ Uddin, S M Naim. Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh.
+ Islam, Mohammad Safiqul. Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh. Electronic address: research_safiq@yahoo.com.
+MeSH Subject Headings
+ *Antioxidants/me [Metabolism]
+ Bangladesh/ep [Epidemiology]
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ Ethnicity
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ *Malondialdehyde/bl [Blood]
+ Middle Aged
+ *Minerals/bl [Blood]
+ *Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Prognosis
+ *Trace Elements/bl [Blood]
+Keyword Heading
+ Bangladesh
+ MDA
+ Macro-minerals
+ Non-enzymatic antioxidants
+ Obesity
+ Trace elements
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND OBJECTIVE: Obesity is an emerging public health concern in Bangladesh. This study aimed to find the levels of the serum malondialdehyde (MDA), non-enzymatic antioxidants (vitamin A, C and E), trace elements (zinc and iron) and macro-minerals (calcium, potassium and sodium) in obesity and its action in disease advancement.
+
+ METHODS: Level of lipid peroxidation was estimated by measurement of the serum concentrations of malondialdehyde (MDA). Vitamin A and E concentration was found by RP-HPLC method and vitamin C was assessed for serum ascorbic acid by UV spectrophotometric method. Serum trace elements (Zn and Fe) and macro-minerals (Na, K and Ca) were estimated by Atomic Absorption Spectroscopy (AAS).
+
+ RESULTS: Our study observed significantly elevated concentrations of MDA (p<0.001) and depleted concentrations of antioxidants (vitamin A, E and C) (p<0.05) in the patient than control group. Analysis of serum trace elements (Zn and Fe) and macro-minerals (Na, K and Ca) and found that the mean values of Zn, Fe, Na, K and Ca were 0.39+/-0.02 and 0.43+/-0.03, 3284.81+/-34.51, 162.18+/-3.72, 44.62+/-2.13mg/L for the patient and 0.91+/-0.13, 0.88+/-0.06, 2562.74+/-95.92, 243.58+/-8.97, 87.66+/-2.10mg/L for the controls, consequently. There was a substantial difference in trace elements and macro-minerals between the patients and controls (p<0.001).
+
+ CONCLUSION: Our study proposes that increased serum concentrations of MDA and decreased non-enzymatic antioxidant and altered trace elements and macro-minerals are powerfully related with obesity. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Minerals). 0 (Trace Elements). 4Y8F71G49Q (Malondialdehyde).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.12.022
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adnan&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Increased+concentration+of+serum+MDA%2C+decreased+antioxidants+and+altered+trace+elements+and+macro-minerals+are+linked+to+obesity+among+Bangladeshi+population.&volume=13&issue=2&spage=933&epage=938&date=2019&doi=10.1016%2Fj.dsx.2018.12.022&pmid=31336547&sid=OVID:medline
+
+<1565>
+Unique Identifier
+ 31336533
+Title
+ Association between dietary habit and diabetic risk profiles among diagnosed Type-2 diabetic patients in a selected area of Bangladesh.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1633-1637, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Majid MA; Bashet MA; Siddique MRF; Rahman ME
+Authors Full Name
+ Majid, Md Abdul; Bashet, Md Abdul; Siddique, Md Ruhul Furkan; Rahman, Md Estiar.
+Institution
+ Majid, Md Abdul. Department of Public Health and Informatics, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh. Electronic address: chanchalahmed76@gmail.com.
+ Bashet, Md Abdul. Department of Public Health and Informatics, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh. Electronic address: utsabsarker77@gmail.com.
+ Siddique, Md Ruhul Furkan. Department of Public Health and Informatics, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh. Electronic address: dr.furkan.siddique@gmail.com.
+ Rahman, Md Estiar. Department of Public Health and Informatics, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh. Electronic address: estiarju@gmail.com.
+MeSH Subject Headings
+ Adult
+ Bangladesh/ep [Epidemiology]
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Feeding Behavior
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+Keyword Heading
+ Diabetic risk profile
+ Dietary habit
+ Type-2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: This study aimed to assess the association of dietary habits on diabetic risk profiles of patients with type-2 diabetes in a selected area, Bangladesh.
+
+ METHODS: This cross sectional study was conducted among 420 type-2 diabetic patients, selected conveniently from Jahangirnagar University and nearest community, Savar, Dhaka. Five days food records were used to determine macronutrient consumption. Blood sample was taken for biochemical investigation and height, weight were taken for BMI measurement. A bivariate Pearson's r correlation analyses were used to assess the association of dietary habit and diabetic risk profiles.
+
+ RESULTS: Out of 420 patients, 228 were male and 172 were female (mean+/-SD of age, 47.5+/-6.4 years). Mean HbA1c was 7.53+/-0.90%. The patients with hypercholesterolemia were 64.8% and hypertriglyceridemia were 39.0%. Patients with high LDL-C were 57.1%. Mean HDL-C was 49.15+/-12.07mg/dl. Among 420 patients, 188 (44.8%) were overweight and 132 (31.4%) were obese. Mean daily carbohydrate, protein and fat consumption was 259.23+/-57.19, 87.21+/-19.08 and 65.07+/-12.23 respectively. Study found that carbohydrate, protein and fat consumption was associated with diabetic risk profiles.
+
+ CONCLUSION: A large number of people's dietary habit has strong association with diabetic risk profile among type-2 diabetic patients. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Lipids). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.03.030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Majid&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+between+dietary+habit+and+diabetic+risk+profiles+among+diagnosed+Type-2+diabetic+patients+in+a+selected+area+of+Bangladesh.&volume=13&issue=2&spage=1633&epage=1637&date=2019&doi=10.1016%2Fj.dsx.2019.03.030&pmid=31336533&sid=OVID:medline
+
+<1566>
+Unique Identifier
+ 31336523
+Title
+ Mini-trampoline rebound exercises: A 'self-care' initiative for glycated hemoglobin, body mass index and emotional distress for mildly obese females with non-insulin dependent type 2 diabetes.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1569-1573, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Maharaj SS; Nuhu JM
+Authors Full Name
+ Maharaj, Sonill S; Nuhu, Jibril M.
+Institution
+ Maharaj, Sonill S. Department of Physiotherapy, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa. Electronic address: maharajss@ukzn.ac.za.
+ Nuhu, Jibril M. Department of Physiotherapy, Bayero University, Kano, Kano State, Nigeria. Electronic address: mjnuhu@yahoo.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Case-Control Studies
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/px [Psychology]
+ *Diabetes Mellitus, Type 2/th [Therapy]
+ *Exercise Therapy
+ Female
+ Follow-Up Studies
+ *Glycated Hemoglobin/an [Analysis]
+ Humans
+ Male
+ Obesity/co [Complications]
+ Obesity/px [Psychology]
+ *Obesity/th [Therapy]
+ Prognosis
+ *Psychological Distress
+ *Self Care
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.11.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Maharaj&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Mini-trampoline+rebound+exercises%3A+A+%27self-care%27+initiative+for+glycated+hemoglobin%2C+body+mass+index+and+emotional+distress+for+mildly+obese+females+with+non-insulin+dependent+type+2+diabetes.&volume=13&issue=2&spage=1569&epage=1573&date=2019&doi=10.1016%2Fj.dsx.2018.11.006&pmid=31336523&sid=OVID:medline
+
+<1567>
+Unique Identifier
+ 31336526
+Title
+ Prevalence of non-alcoholic fatty liver disease in patients with diabetes mellitus, hyperlipidemia, obesity and polycystic ovary syndrome: A cross-sectional study in north of Iran.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1591-1596, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mansour-Ghanaei F; Joukar F; Mobaraki SN; Mavaddati S; Hassanipour S; Sepehrimanesh M
+Authors Full Name
+ Mansour-Ghanaei, Fariborz; Joukar, Farahnaz; Mobaraki, Sahar Najafi; Mavaddati, Sara; Hassanipour, Soheil; Sepehrimanesh, Masood.
+Institution
+ Mansour-Ghanaei, Fariborz. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
+ Joukar, Farahnaz. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; Caspian Digestive Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: farajov@gmail.com.
+ Mobaraki, Sahar Najafi. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
+ Mavaddati, Sara. Universita degli Studi di Bari Aldo Moro, Bari, Italy.
+ Hassanipour, Soheil. GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran.
+ Sepehrimanesh, Masood. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran.
+MeSH Subject Headings
+ Adult
+ Biomarkers/an [Analysis]
+ Cross-Sectional Studies
+ *Diabetes Mellitus/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Hyperlipidemias/co [Complications]
+ Iran/ep [Epidemiology]
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Obesity/co [Complications]
+ *Polycystic Ovary Syndrome/co [Complications]
+ Prevalence
+ Prognosis
+Keyword Heading
+ Diabetes mellitus
+ Hyperlipidemia
+ Non-alcoholic fatty liver disease
+ Obesity
+ Polycystic ovaries syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: The aim of this study was to describe the frequency of non-alcoholic fatty liver disease (NAFLD) in patients with diabetes mellitus (DM), hyperlipidemia, obesity and polycystic ovaries syndrome (PCOS).
+
+ METHODS: In a cross-sectional study, 333 patients who had one of the certain diagnosis of DM, hyperlipidemia, obesity or PCOS were enrolled. Information about demographics, anthropometric, nutritional habitude, smoking history, medical history and physical activity were recorded. Liver ultrasound examination and routine biochemistry analysis were performed.
+
+ RESULTS: Among 333 patients with one of the four above-mentioned diseases. 199 patients (59.8%) had NAFLD. Male were more likely to have NAFLD than female (72.8% vs. 50.8% respectively, P<0.001). About, 80.7% of patients through 41-50 years age had NAFLD. The frequency of abnormal fasting blood glucose, alanine aminotransferase (ALT), triglyceride, and total cholesterol were significantly higher in patients with NAFLD (P<0.05). Subjects with NAFLD had a higher body mass index than non-NAFLD (33.6+/-7.9kg/m2 vs. 31.1+/-5.0kg/m2 respectively, P=0.002). Patients with DM, hyperlipidemia, hypertension, and hypothyroidism were more likely to have NAFLD (P<0.05). Patients with consumption of supper, high-fat diet, enjoy of eating and smoking were more likely to have NAFLD and patients with fruit and vegetable uptake and physical activity were less likely to have NAFLD (P<0.05).
+
+ CONCLUSIONS: As most patients with NAFLD are asymptomatic, employed individuals with higher education levels, with a history of smoking and unhealthy diet along with DM, hyperlipidemia, PCOS and obesity seriously have to be followed and educated for lifestyle modification. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.03.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mansour-Ghanaei&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Prevalence+of+non-alcoholic+fatty+liver+disease+in+patients+with+diabetes+mellitus%2C+hyperlipidemia%2C+obesity+and+polycystic+ovary+syndrome%3A+A+cross-sectional+study+in+north+of+Iran.&volume=13&issue=2&spage=1591&epage=1596&date=2019&doi=10.1016%2Fj.dsx.2019.03.009&pmid=31336526&sid=OVID:medline
+
+<1568>
+Unique Identifier
+ 31336506
+Title
+ Relationship between Vitamin D Deficiency, Diabetes, and Obesity.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1457-1461, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alloubani A; Akhu-Zaheya L; Samara R; Abdulhafiz I; Saleh A; Altowijri A
+Authors Full Name
+ Alloubani, Aladeen; Akhu-Zaheya, Laila; Samara, Rama; Abdulhafiz, Ibrahim; Saleh, Abdulmoneam; Altowijri, Albaraa.
+Institution
+ Alloubani, Aladeen. Nursing Research & EBP Unit, King Hussein Cancer Center, Queen Rania Al Abdullah Street (next to Jordan University), P.O.Box 1269, Amman, 11941, Jordan; Harvard Medical School, USA. Electronic address: aa.12567@khcc.jo.
+ Akhu-Zaheya, Laila. Jordan University of Science and Technology, Ar Ramtha 3030, Ramtha, Jordan. Electronic address: lailanurse@just.edu.jo.
+ Samara, Rama. Jordan University of Science and Technology, Ar Ramtha 3030, Ramtha, Jordan. Electronic address: samaraa@yahoo.com.
+ Abdulhafiz, Ibrahim. Faculty of Medicine, University of Tabuk, Saudi Arabia. Electronic address: iabdel-hafiz@ut.edu.sa.
+ Saleh, Abdulmoneam. Faculty of Medicine, University of Tabuk, Saudi Arabia. Electronic address: asaleh@ut.edu.sa.
+ Altowijri, Albaraa. Faculty of Medicine, University of Tabuk, Saudi Arabia. Electronic address: aaltowijri@ut.edu.sa.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Age Factors
+ Biomarkers/an [Analysis]
+ Cross-Sectional Studies
+ *Diabetes Mellitus/ep [Epidemiology]
+ Diabetes Mellitus/et [Etiology]
+ *Diet
+ Exercise
+ Female
+ Follow-Up Studies
+ Humans
+ *Life Style
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Prevalence
+ Prognosis
+ Risk Factors
+ Saudi Arabia/ep [Epidemiology]
+ *Vitamin D Deficiency/co [Complications]
+ Young Adult
+Keyword Heading
+ Diabetes
+ Nutrition
+ Obesity
+ Vitamin D deficiency
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: This study aimed to assess the prevalence of VDD in Saudi Arabia, revealing the lifestyle and nutritional habits; and assesses the association between VDD, Diabetes Mellitus, and obesity.
+
+ METHODS: A descriptive, cross-sectional, and correlational design was used in this study. A convenience sampling method of 350 participants participated in the study.
+
+ RESULTS: The results revealed that the probability of having vitamin D Deficiency was higher among females (OR=2.06, p>.05); younger age-whereby with each one year decrease in age there was about 0.03 probability of having Vitamin D Deficiency (B=-0.03; p>.05); individuals with higher incomes (OR=1.44, p>.05); smokers (OR=0.08, p>.05); and a lack of exposure to the sun (OR=8.50; p>.05). In addition, exercise is also a predictor of Vitamin D deficiency (OR=3.8; p>.05). Moreover, less Vitamin D intake (OR 9.7; p>.05), less intake of Calcium (OR=12.2, p>.05); In addition increase one unit in the BMI, cholesterol, LDL, HDL, and FBS increased the log odd of having liability of Vitamin D deficiency by 3.2; 1.9, 1.8, 1.0, and 2.4 (p>.05).
+
+ CONCLUSION: Vitamin D Deficiency was prevalent in both males and females across different age groups in the citizens of Saudi. Because of the connection between Vitamin D Deficiency and main chronic disease, it is necessary to emphasize the need to recognize Vitamin D Deficiency screening for risk factors. It may be reasonable for the nutritionists, nurses, and physicians, to encourage the community on approaches to enhance dietary Vitamin D or suggest supplementation. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.02.021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alloubani&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Relationship+between+Vitamin+D+Deficiency%2C+Diabetes%2C+and+Obesity.&volume=13&issue=2&spage=1457&epage=1461&date=2019&doi=10.1016%2Fj.dsx.2019.02.021&pmid=31336506&sid=OVID:medline
+
+<1569>
+Unique Identifier
+ 31336495
+Title
+ Health indicators and costs among outpatients according to physical activity level and obesity.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1375-1379, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Morais LC; Rocha APR; Turi-Lynch BC; Ferro IS; Koyama KAK; Araujo MYC; Codogno JS
+Authors Full Name
+ Morais, Luana C; Rocha, Ana Paula R; Turi-Lynch, Bruna C; Ferro, Izabela S; Koyama, Kelly A K; Araujo, Monique Y C; Codogno, Jamile S.
+Institution
+ Morais, Luana C. Sao Paulo State University Department of Physical Education, School of Sciences and Technology, Sao Paulo State University-UNESP, 305 Roberto Simonsen, 19060-900, Presidente Prudente, Brazil. Electronic address: luanaeducacaofisica@hotmail.com.
+ Rocha, Ana Paula R. Department of Physiotherapy, Woman's Health Research Laboratory - LAMU, Federal University of Sao Carlos - UFSCar, 235 Km Rod. Washington Luis, 13565-905, Sao Carlos, Brazil. Electronic address: rodrigues.anarocha@gmail.com.
+ Turi-Lynch, Bruna C. Department of Physical Education, School of Sciences and Technology, Sao Paulo State University-UNESP, 305 Roberto Simonsen, 19060-900, Presidente Prudente, Brazil. Electronic address: brunaturi@hotmail.com.
+ Ferro, Izabela S. Department of Physical Education, School of Sciences and Technology, Sao Paulo State University, 305 Rua Roberto Simonsen, 19060-900, Presidente Prudente, Brazil. Electronic address: izabela13@gmail.com.
+ Koyama, Kelly A K. Department of Physiotherapy, Woman's Health Research Laboratory - LAMU, Federal University of Sao Carlos - UFSCar, 235 Km Rod. Washington Luis, 13565-905, Sao Carlos, Brazil. Electronic address: kelly.akk@hotmail.com.
+ Araujo, Monique Y C. Department of Physiotherapy, Woman's Health Research Laboratory - LAMU, Federal University of Sao Carlos - UFSCar, 235 Km Rod. Washington Luis, 13565-905, Sao Carlos, Brazil. Electronic address: mo_castanho@hotmail.com.
+ Codogno, Jamile S. Department of Physiotherapy, Woman's Health Research Laboratory - LAMU, Federal University of Sao Carlos - UFSCar, 235 Km Rod. Washington Luis, 13565-905, Sao Carlos, Brazil. Electronic address: jamile.codogno@unesp.br.
+MeSH Subject Headings
+ Aged
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Composition
+ Body Mass Index
+ *Exercise
+ Female
+ Follow-Up Studies
+ Humans
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/ec [Economics]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ *Outpatients/sn [Statistics & Numerical Data]
+ Prognosis
+Keyword Heading
+ National healthcare system
+ Obesity
+ Physical activity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: How biochemical variables influence the costs of the Brazilian National Healthcare System, according to body composition and physical activity.
+
+ METHODS: Participated in this study 168 patients. Biochemical variables were glucose, triglycerides, total cholesterol, high, low, very low density lipoprotein and C-reactive protein (CRP). For the cost analysis the medical records was analyzed. Physical activity was assessed through questionnaire. Body adiposity was assessed by body mass index. Four groups were defined according body adiposity and physical activity.
+
+ RESULTS: The active obese group had higher values of very low density lipoprotein and triglycerides when compared to the inactive obese. The non-obese inactive group had lower values of non-high density lipoprotein compared to the inactive obese. The non-obese active group presented lower insulin value when compared to the inactive obese. The inactive obese group presented higher values in the CRP when compared to the non-obese active and inactive groups when compared to non-obese and active obese group. There was a positive correlation between insulin, glucose, CRP and drug and total costs.
+
+ CONCLUSIONS: Biochemical variables were different according to body composition and physical activity. Insulin, glucose and CRP were related to cost in drugs and total costs. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.02.018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Morais&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Health+indicators+and+costs+among+outpatients+according+to+physical+activity+level+and+obesity.&volume=13&issue=2&spage=1375&epage=1379&date=2019&doi=10.1016%2Fj.dsx.2019.02.018&pmid=31336495&sid=OVID:medline
+
+<1570>
+Unique Identifier
+ 31336494
+Title
+ The association between dietary antioxidants and adipokines level among obese women.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1369-1373, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Daneshzad E; Farsad-Naeimi A; Heshmati J; Mirzaei K; Maghbooli Z; Keshavarz SA
+Authors Full Name
+ Daneshzad, Elnaz; Farsad-Naeimi, Alireza; Heshmati, Javad; Mirzaei, Khadijeh; Maghbooli, Zhila; Keshavarz, Seyed-Ali.
+Institution
+ Daneshzad, Elnaz. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, 14155-6117, Iran.
+ Farsad-Naeimi, Alireza. Department of Nutrition, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
+ Heshmati, Javad. Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, 14155-6117, Iran. Electronic address: mina_mirzaei101@yahoo.com.
+ Maghbooli, Zhila. Osteoporosis Research Center, Endocrine Diseases and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Keshavarz, Seyed-Ali. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adult
+ Angiopoietin-Like Protein 6
+ *Angiopoietin-like Proteins/bl [Blood]
+ *Antioxidants/me [Metabolism]
+ *Biomarkers/an [Analysis]
+ Body Composition
+ Cross-Sectional Studies
+ *Diet
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ Iran/ep [Epidemiology]
+ Male
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ *Retinol-Binding Proteins, Plasma/an [Analysis]
+ Vitamins/ad [Administration & Dosage]
+Keyword Heading
+ ANGPTL6
+ Adipokines
+ Antioxidants
+ Obesity
+ Progranulin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Adipokines are associated with several oxidative stress-related diseases and pathologic conditions. We aimed to assess the association between antioxidants and adipokines in obese adults.
+
+ METHODS AND MATERIALS: In this cross-sectional study, a total of 160 obese women were included. Body composition and anthropometric characteristics were measured. Dietary intakes were assessed by 3-day, 24-h dietary recall. Blood samples were obtained following an overnight fasting. Serum concentrations of adipokines including progranulin, retinol binding protein 4 (RBP4) and Angiopoietin-related growth factor 6 (ANGPTL6) was measured using an enzyme-linked immunosorbent assay. ANCOVA and the linear regression model analysis was performed to assess the relationship between Progranulin, RBP4, AnGPTL6, and antioxidants.
+
+ RESULTS: Mean age of included women was 39.31+/-12.10. Mean and standard deviation for BMI was 35.05+/-4.26 in this obese population. There was a positive significant association between ANGPTL6 and vitamin D intake (p<0.001). Also, there was a marginal association between RBP4 and vitamin A (p=0.063) intake, but after adjustment age, and fat mass, we found a significant association (p=0.008). However, the associations between dietary antioxidants, progranulin, and ANGPTL6 were not statistically significant.
+
+ CONCLUSIONS: ANGPTL6 and RBP4 levels directly associated with dietary vitamins D and A intake, respectively. But, according to the results, the association between ANGPTL6 and vitamin D was bidirectional. The suggested associations probably can be useful in the development of interventional studies for management of chronic diseases. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ANGPTL6 protein, human). 0 (Adipokines). 0 (Angiopoietin-Like Protein 6). 0 (Angiopoietin-like Proteins). 0 (Antioxidants). 0 (Biomarkers). 0 (RBP4 protein, human). 0 (Retinol-Binding Proteins, Plasma). 0 (Vitamins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.02.022
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Daneshzad&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=The+association+between+dietary+antioxidants+and+adipokines+level+among+obese+women.&volume=13&issue=2&spage=1369&epage=1373&date=2019&doi=10.1016%2Fj.dsx.2019.02.022&pmid=31336494&sid=OVID:medline
+
+<1571>
+Unique Identifier
+ 31336493
+Title
+ Population attributable risk of risk factors for type 2 diabetes; Bayesian methods.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1365-1368, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fallahzadeh H; Ostovarfar M; Lotfi MH
+Authors Full Name
+ Fallahzadeh, Hosein; Ostovarfar, Maral; Lotfi, Mohammad Hassan.
+Institution
+ Fallahzadeh, Hosein. Research Center of Prevention & Epidemiology of Non-Communicable Disease, Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: fallahzadeh.ho@gmail.com.
+ Ostovarfar, Maral. Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: ostovar.bio@gmail.com.
+ Lotfi, Mohammad Hassan. Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: mhlotfi56359@gmail.com.
+MeSH Subject Headings
+ Aged
+ *Bayes Theorem
+ Biomarkers/an [Analysis]
+ *Cardiovascular Diseases/pp [Physiopathology]
+ Cohort Studies
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Exercise
+ Female
+ Follow-Up Studies
+ Humans
+ *Hypertension/pp [Physiopathology]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ *Smoking/pp [Physiopathology]
+ Socioeconomic Factors
+Keyword Heading
+ Population attributable risk
+ Risk factors
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Demonstrating the risk factors of diabetes can help to plan for prevention of this disease. This study aimed at quantification of the impact of physical activity, hypertension, general obesity, central obesity, high cholesterol, HDL, LDL, triglyceride, smoking, hookah, drug use, alcohol consumption on the incidence of type 2 diabetes at a population level in Yazd, Iran. And this study calculated population attributable risk (PAR) of them.
+
+ METHODS: For this study, data from the first phase of the cohort study of chronic diseases in the adults of Yazd city were used, which began in 2016. Data was recorded through a cohort trained team. To calculate PAR and its the Bayesian confidence interval were performed using software R (version 3.4.3).
+
+ RESULTS: Of the 9967 subjects studied, age >=30, 14.67% (n=1432) has type 2 diabetes. The most common risk factors for diabetes were Inadequate physical activity and central obesity (WHR). The PAR for Inadequate physical activity of diabetes in women was 17.92%, in men 18.53, And PAR for WHR in women was 57.62%, in men 43.03.
+
+ CONCLUSIONS: In this study, age was the strongest determinant of diabetes. And then type 2 diabetes is mainly attributable to WHR, significantly more so in women than men. Therefore, central obesity probably should be considered as a major strategy for reducing incidence of type 2 diabetes. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fallahzadeh&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Population+attributable+risk+of+risk+factors+for+type+2+diabetes%3B+Bayesian+methods.&volume=13&issue=2&spage=1365&epage=1368&date=2019&doi=10.1016%2Fj.dsx.2019.01.015&pmid=31336493&sid=OVID:medline
+
+<1572>
+Unique Identifier
+ 31336480
+Title
+ Association between selected trace elements and body mass index and waist circumference: A cross sectional study.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1293-1297, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zohal M; Jam-Ashkezari S; Namiranian N; Moosavi A; Ghadiri-Anari A
+Authors Full Name
+ Zohal, Mahnaz; Jam-Ashkezari, Saeedeh; Namiranian, Nasim; Moosavi, Amin; Ghadiri-Anari, Akram.
+Institution
+ Zohal, Mahnaz. Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Jam-Ashkezari, Saeedeh. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Namiranian, Nasim. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Moosavi, Amin. Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Ghadiri-Anari, Akram. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: ghadiriam@ssu.ac.ir.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Iran/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ *Overweight/ep [Epidemiology]
+ Overweight/me [Metabolism]
+ Overweight/pp [Physiopathology]
+ Prevalence
+ Prognosis
+ *Trace Elements/an [Analysis]
+ *Waist Circumference
+ Young Adult
+Keyword Heading
+ Calcium
+ Central obesity
+ Magnesium
+ Minerals
+ Phosphate
+ Zinc
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The prevalence of obesity has increased worldwide. Abnormal plasma level of some trace elements may be associated with obesity. The present study was designed to compare the plasma level of zinc, phosphate, calcium and magnesium with the degree of body mass index and waist circumference.
+
+ MATERIAL AND METHODS: In this cross sectional study 149 persons (20-60 years old) from March 2014 till April 2017 were included. Definition of central obesity was waist circumference (WC)>= 102cm and >=88cm in men and women, respectively. Also BMI categorized to: normal weight: 18.50-24.99, overweight: 25.00-29.99 and obese: >=30kg/m2 respectively. Mg, Ca, P and Zinc in plasma was checked after12h fasting in each persons. Comparison between the level of Mg, P, Ca and Zinc by three categories of BMI or waist circumference performed. The data were analyzed by independent T-test and one-way ANOVA. Scheffe method was used to determine post-hoc pair-wise comparisons. The relationship between BMI and concentration of elements was detected by linear correlation and Cubic model. A p<=0.05 were considered statistically significant. Statistical analyses were executed by SPSS version 20.
+
+ RESULTS: In this study, 32.2% male and remainder female, mean age of 42.26+/-13.03 were participated. 40.9% were normal and 59.1% obese base on waist circumference. Also 24.8% normal,44.3% overweight and remainder was obese according to BMI. Obese subjects base on waist circumference had significantly lower serum Zinc(pvalue:0.002), Ca (pvalue:0.0001)and Mg(pvalue:0.042) concentration. Whereas, P concentration was significantly higher in obese cases in comparison with normal subjects(pvalue:0.012). Also normal cases had significantly higher serum Zinc (pvalue: 0.0001), Ca (pvalue:0.0001), and Mg(pvalue:0.006) concentration compared to overweight and obese subjects according to BMI categorizes.
+
+ CONCLUSION: Inverse correlation present between plasma zinc, calcium and magnesium level and BMI and waist circumference, but positive correlation seen between P level and waist circumference. Further studies are needed to evaluate the effect of dietary or supplemental interventions on obesity and central obesity. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Trace Elements).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.019
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zohal&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+between+selected+trace+elements+and+body+mass+index+and+waist+circumference%3A+A+cross+sectional+study.&volume=13&issue=2&spage=1293&epage=1297&date=2019&doi=10.1016%2Fj.dsx.2019.01.019&pmid=31336480&sid=OVID:medline
+
+<1573>
+Unique Identifier
+ 31336456
+Title
+ Leptin level decreases after treatment with the combination of Radiofrequency and Ultrasound cavitation in response to the reduction in adiposity.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1137-1140, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Arabpour-Dahoue M; Mohammadzadeh E; Avan A; Nezafati P; Nasrfard S; Ghazizadeh H; Mehramiz M; Safarian M; Nematy M; Jarahi L; Ferns GA; Norouzy A; Ghayour-Mobarhan M
+Authors Full Name
+ Arabpour-Dahoue, Mahla; Mohammadzadeh, Elham; Avan, Amir; Nezafati, Pouya; Nasrfard, Samira; Ghazizadeh, Hamideh; Mehramiz, Mehrane; Safarian, Mohammad; Nematy, Mohsen; Jarahi, Lida; Ferns, Gordon A; Norouzy, Abdolreza; Ghayour-Mobarhan, Majid.
+Institution
+ Arabpour-Dahoue, Mahla. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Mohammadzadeh, Elham. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Avan, Amir. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Nezafati, Pouya. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Nasrfard, Samira. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ghazizadeh, Hamideh. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Mehramiz, Mehrane. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Safarian, Mohammad. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Nematy, Mohsen. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Jarahi, Lida. Department of Community Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ferns, Gordon A. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH, UK.
+ Norouzy, Abdolreza. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Norouzya@mums.ac.ir.
+ Ghayour-Mobarhan, Majid. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghayourm@mums.ac.ir.
+MeSH Subject Headings
+ *Adiposity/re [Radiation Effects]
+ Adult
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ Combined Modality Therapy
+ Female
+ Follow-Up Studies
+ Humans
+ *Leptin/bl [Blood]
+ Male
+ *Obesity/bl [Blood]
+ *Obesity/th [Therapy]
+ Prognosis
+ *Pulsed Radiofrequency Treatment/mt [Methods]
+ *Ultrasonic Therapy/mt [Methods]
+Keyword Heading
+ Leptin
+ Obesity (overweight)
+ Radiofrequency
+ Randomized controlled
+ Ultrasound cavitation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity and overweight are major public health problem. Different-strategies have been developed for body contouring including Radiofrequency(RF) and Ultrasound(US). The aim of this study was to investigate changes in serum-leptin as a potential-modulator of food/energy intake, in overweight-women receiving RF/US and diet-therapy as well as the effect of therapy on modulation of lipid-profile and body-fat-mass.
+
+ METHODS: Fifty overweight-females were enrolled in current randomized-clinical-trial and randomly divided into two groups. The case group received RF/US twice a week for 5 weeks with a low calorie diet whilst the control-group received just a low calorie diet. Demographic, biochemical markers as well as serum-leptin were determined.
+
+ RESULTS: The level of leptin was reduced from 1.29+/-0.32ng/ml to 1.14+/-0.34ng/ml in case group, before and after therapy, respectively, whilst no significant differences were observed in the serum leptin levels of subjects in the control group. The combination of RF and US decreased the leptin-level. In particular, the mean reduction of abdominal-circumference and waist-circumference was significant (P<0.05) after therapy. This reduction was inversely correlated with LDL levels. Weight was reduced in case and control groups and in both was significant, but no statistically significant differences were detected for weight between the groups(P<0.93).
+
+ CONCLUSION: Our findings demonstrated the reduction of the leptin after treatment with the combination of Radiofrequency/Ultrasound cavitation, which was associated with reduced body-fat-mass. Copyright © 2019 Diabetes India. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.046
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Arabpour-Dahoue&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Leptin+level+decreases+after+treatment+with+the+combination+of+Radiofrequency+and+Ultrasound+cavitation+in+response+to+the+reduction+in+adiposity.&volume=13&issue=2&spage=1137&epage=1140&date=2019&doi=10.1016%2Fj.dsx.2019.01.046&pmid=31336456&sid=OVID:medline
+
+<1574>
+Unique Identifier
+ 31336446
+Title
+ Association of demographic and socioeconomic characteristics with body mass index of outpatient diabetic adults attending a tertiary health facility in Enugu, Nigeria.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1071-1076, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Henry-Unaeze HN; Ngwu EK; Nwamara JU
+Authors Full Name
+ Henry-Unaeze, H N; Ngwu, E K; Nwamara, J U.
+Institution
+ Henry-Unaeze, H N. Department of Human Nutrition and Dietetics, College of Applied Food Sciences and Tourism, Michael Okpara University of Agriculture Umudike, PMB 7267, Umuahia, Abia State, Nigeria. Electronic address: henry-unaeze.helen@mouau.edu.ng.
+ Ngwu, E K. Department of Nutrition and Dietetics, Faculty of Agriculture, University of Nigeria Nsukka, Enugu State, Nigeria.
+ Nwamara, J U. Department of Nutrition and Dietetics, Faculty of Agriculture, University of Nigeria Nsukka, Enugu State, Nigeria.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Demography
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ Nigeria/ep [Epidemiology]
+ Nutritional Status
+ *Obesity/pp [Physiopathology]
+ *Outpatients/sn [Statistics & Numerical Data]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ Rural Population
+ *Socioeconomic Factors
+ Tertiary Healthcare
+ Young Adult
+Keyword Heading
+ BMI
+ Demographic
+ Out-patient
+ Socioeconomic
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND/OBJECTIVE: Recently, demographic and socioeconomic characteristics have been emphasized in dealing with chronic diseases of which Type 2 diabetes (T2D) is one. This present study was conducted to correlate the demographic and socioeconomic characteristics of out-patient type 2 diabetic adults with their body mass index (BMI).
+
+ METHODOLOGY: This cross-sectional study was conducted in the Out-patients Diabetic clinic of University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu Nigeria. A total of 370 subjects were purposively selected from the 2888 annual average attendances and examined with questionnaire and anthropometry. Information on their demographic and socioeconomic characteristics was correlated with their body mass index.
+
+ RESULT: The results indicated that there were more (59%) urban diabetics than rural (25.7%) diabetics, many (65.7%) were within the age range of 41-60years, more (64.9%) females than males (35.1%), mainly (86.2%) married and of Christian religion (94.1%) and Igbo ethnicity (95.9%). The majority (91.1%) were of a monogamous family type with 55.4% from average sized (4-6persons) families. More than 1/3 (34.1%) had tertiary education, mainly (43%) civil servants, and 45.1% earning above 137.21 US Dollar per month. Most (69%) of the diabetics were over-weight, a trend of both under-nutrition (1.1%), and over-nutrition (68.7%) with mean BMI value of 27.19kg/m2 was also observed. BMI had slight negative association with age, sex, and occupation and positive association with religion, ethnicity, marital status and level of education.
+
+ CONCLUSION: There is a weak negative association of age, sex and occupation with BMI. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.026
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Henry-Unaeze&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+of+demographic+and+socioeconomic+characteristics+with+body+mass+index+of+outpatient+diabetic+adults+attending+a+tertiary+health+facility+in+Enugu%2C+Nigeria.&volume=13&issue=2&spage=1071&epage=1076&date=2019&doi=10.1016%2Fj.dsx.2019.01.026&pmid=31336446&sid=OVID:medline
+
+<1575>
+Unique Identifier
+ 31336442
+Title
+ Identification of risk factors affecting impaired glucose metabolism among the adult population of district Srinagar.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1047-1051, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Saleem SM; Jan SS; Haq I; Khan SMS
+Authors Full Name
+ Saleem, Sheikh Mohd; Jan, Shah Sumaya; Haq, Inaamul; Khan, S Muhammad Salim.
+Institution
+ Saleem, Sheikh Mohd. Department of Community Medicine, Government Medical College, Srinagar, India. Electronic address: saleem.900@gmail.com.
+ Jan, Shah Sumaya. Department of Anatomy, Government Medical College, Srinagar, India.
+ Haq, Inaamul. Department of Community Medicine, Government Medical College, Srinagar, India.
+ Khan, S Muhammad Salim. Department of Community Medicine, Government Medical College, Srinagar, India.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ *Glucose Intolerance/ep [Epidemiology]
+ *Glucose Intolerance/et [Etiology]
+ Glucose Intolerance/me [Metabolism]
+ Glucose Intolerance/pa [Pathology]
+ Humans
+ India/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Prevalence
+ Prognosis
+ Risk Factors
+ *Waist Circumference
+ Young Adult
+Keyword Heading
+ Diabetes and prediabetes
+ Diabetes in adults
+ Glucose metabolism
+ Prediabetes
+ Type 2 DM
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The World has seen an emerging trend of diabetes among adolescents and moderately aged people over the last decade. The aim of the study was to identify the risk factors associated with impaired glucose metabolism and the prevalence of impaired glucose metabolism among the adult population of district Srinagar.
+
+ METHODS: Multi-stage cluster random sampling design was used and from each household, participants were selected using a Kish grid method. Socio-demographic and clinical data were collected. The participants were then subjected to fasting venous blood glucose estimation.
+
+ RESULTS: Age, waist circumference, hip circumference, weight, and body mass index were all statistically significant between normoglycemic participants and those with impaired glucose metabolism (p<0.018). On logistic regression, subjects who had a higher BMI were more likely to develop Impaired glucose metabolism (OR=3.52, OR 95% CI=1.25-9.87); Moreover, consumption of carbonated drinks, (3-6 times/week OR=4.40, OR 95% CI=2.06-9.40; >6 times/week OR=11.04, OR 95% CI=0.86-140.66) was found to be a potential risk factor. Participants with a family history of diabetes were more susceptible to develop impaired glucose metabolism (OR=6.41, OR 95% CI=3.22-12.78). The risk effect of these factors was even stronger before adjusting for age, sex, family history of diabetes, and BMI in participants.
+
+ CONCLUSION: Risk factors for impaired glucose metabolism include increasing age, obesity, and higher consumption of carbonated drinks, hypertension, smoking behavior, high-calorie diet intake and positive family history of diabetes. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.023
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Saleem&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Identification+of+risk+factors+affecting+impaired+glucose+metabolism+among+the+adult+population+of+district+Srinagar.&volume=13&issue=2&spage=1047&epage=1051&date=2019&doi=10.1016%2Fj.dsx.2019.01.023&pmid=31336442&sid=OVID:medline
+
+<1576>
+Unique Identifier
+ 31336441
+Title
+ Body-mass index and the risk of albuminuria in hypertensive patients with a poor estimated glomerular filtration rate and the potential role of diabetes mellitus.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1041-1046, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Raikou VD; Gavriil S
+Authors Full Name
+ Raikou, Vaia D; Gavriil, Sotiris.
+Institution
+ Raikou, Vaia D. Dpt of Nephrology, DOCTORS' Hospital, Athens, Greece. Electronic address: vraikou@med.uoa.gr.
+ Gavriil, Sotiris. Dpt of Bariatric Surgery, DOCTORS' Hospital, Athens, Greece. Electronic address: sotiris@sgavriil.gr.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ *Albuminuria/et [Etiology]
+ Albuminuria/me [Metabolism]
+ Albuminuria/pa [Pathology]
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ *Diabetes Mellitus/et [Etiology]
+ Diabetes Mellitus/me [Metabolism]
+ Diabetes Mellitus/pa [Pathology]
+ Female
+ Follow-Up Studies
+ *Glomerular Filtration Rate
+ Humans
+ *Hypertension/co [Complications]
+ Hypertension/me [Metabolism]
+ Hypertension/pa [Pathology]
+ Kidney Function Tests
+ Male
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ *Renal Insufficiency, Chronic/et [Etiology]
+ Renal Insufficiency, Chronic/me [Metabolism]
+ Renal Insufficiency, Chronic/pa [Pathology]
+ Risk Factors
+ Waist Circumference
+Keyword Heading
+ Albuminuria
+ Diabetes mellitus
+ Hypertension
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity-related to metabolic syndrome was associated with a greater risk for development of chronic kidney disease (CKD). We aimed to assess the association between obesity and micro/macroalbuminuria in hypertensive patients with a poor estimated glomerular filtration rate (eGFR)<60mL/min/1.73m2.
+
+ METHODS: One hundred old patients (median age 79 years+/-inter-quartile range 68-84.7) with manifested hypertension (systolic blood pressure>=130mmHg and/or diastolic blood pressure>=85mmHg) and a permanently poor eGFR for a duration time more than 3 months were enclosed. Albuminuria was defined as urinary albumin-to-creatinine ratio (ACR)>=30 mg/gr and it was classified according to KDIGO 2012. The obesity was defined by a high body mass index (BMI>30kg/m2). The waist circumference, HDL-C, triglycerides and serum glucose were measured. Chi-square tests and an adjusted model were performed.
+
+ RESULTS: Chi-square tests showed significant association between classified albuminuria and both obesity and high serum triglycerides (x2=7.2, p=0.02 and x2=8.3, p=0.01 respectively). However, the adjusted model for the prediction of albuminuria showed that the presence of a high BMI was a non-significant risk factor, although diabetes mellitus and eGFR value were found to be significant risk factors (p=0.03, OR=4.3, 1.2-22.07 and p=0.04, OR=0.9, 0.9-1.007 respectively) adjusting to covariates including the high waist circumference.
+
+ CONCLUSION: Obesity defined by a high BMI was not found to be a significant risk factor for micro/macroalbuminuria in hypertensive patients with a poor estimated glomerular filtration rate, when diabetes mellitus and the low eGFR value act as confounders. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Raikou&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Body-mass+index+and+the+risk+of+albuminuria+in+hypertensive+patients+with+a+poor+estimated+glomerular+filtration+rate+and+the+potential+role+of+diabetes+mellitus.&volume=13&issue=2&spage=1041&epage=1046&date=2019&doi=10.1016%2Fj.dsx.2019.01.017&pmid=31336441&sid=OVID:medline
+
+<1577>
+Unique Identifier
+ 31336435
+Title
+ Serum AGEs and sRAGE levels are not related to vascular complications in patients with prediabetes.
+Source
+ Diabetes & Metabolic Syndrome. 13(2):1005-1010, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gateva AT; Assyov YS; Tsakova AD; Kamenov ZA
+Authors Full Name
+ Gateva, Antoaneta T; Assyov, Yavor S; Tsakova, Adelina D; Kamenov, Zdravko A.
+Institution
+ Gateva, Antoaneta T. Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University-Sofia, 1 Georgi Sofiiski str, 1431, Sofia, Bulgaria. Electronic address: tony_gateva@yahoo.com.
+ Assyov, Yavor S. Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University-Sofia, 1 Georgi Sofiiski str, 1431, Sofia, Bulgaria.
+ Tsakova, Adelina D. Central Clinical Laboratory, University Hospital "Alexandrovska", Medical University-Sofia, 1 Georgi Sofiiski str, 1431, Sofia, Bulgaria.
+ Kamenov, Zdravko A. Clinic of Endocrinology, University Hospital "Alexandrovska", Medical University-Sofia, 1 Georgi Sofiiski str, 1431, Sofia, Bulgaria.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ *Glycation End Products, Advanced/bl [Blood]
+ Humans
+ Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Prediabetic State/co [Complications]
+ Prognosis
+ *Receptor for Advanced Glycation End Products/bl [Blood]
+Keyword Heading
+ Pentosidine
+ Prediabetes
+ Vascular complications
+ sRAGE
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: While hyperglycemia has a key role in the pathogenesis of microvascular complications of diabetes, it is just one of the many factors contributing to macrovascular damage. The aim of the present study is to investigate the link between serum pentosidine and sRAGE levels and vascular complications in patients with prediabetes compared to normal glucose tolerance controls with obesity.
+
+ METHODS: In this study were included 76 patients with mean age 50.7+/-10.7 years, divided into two age and BMI-matched groups - group 1 with obesity without glycemic disturbances (n=38) and group 2 with obesity and prediabetes (n=38).
+
+ RESULTS: There was no significant difference in pentosidine and sRAGE levels between patients with obesity and prediabetes. Patients with hypertension had lower levels of sRAGE compared to nonhypertensive subjects. sRAGE showed a weak negative correlation to blood glucose on 60th min of OGTT and HOMA index. There was no correlation between sRAGE and pentosidine levels and the markers of micro- and macrovascular complications. There was no difference in sRAGE and pentosidine levels between patients with and without endothelial dysfunction.
+
+ CONCLUSIONS: sRAGE and pentosidine levels are similar in patients with obesity with and without prediabetes and do not correlate to the markers of micro- and macrovascular complications. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycation End Products, Advanced). 0 (Receptor for Advanced Glycation End Products).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gateva&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Serum+AGEs+and+sRAGE+levels+are+not+related+to+vascular+complications+in+patients+with+prediabetes.&volume=13&issue=2&spage=1005&epage=1010&date=2019&doi=10.1016%2Fj.dsx.2019.01.014&pmid=31336435&sid=OVID:medline
+
+<1578>
+Unique Identifier
+ 31335732
+Title
+ Association of atopic dermatitis with obesity via a multi-omics approach: A protocol for a case-control study.
+Source
+ Medicine. 98(29):e16527, 2019 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Son MJ; Yang GJ; Jo EH; Shim YH; Kang SJ; Hong JE; Kim YE; Lee JE; Chun J; Park S; Jung J; Park MC
+Authors Full Name
+ Son, Mi Ju; Yang, Geum-Jin; Jo, Eun-Heui; Shim, Yu-Hwa; Kang, Su-Jin; Hong, Ji-Eun; Kim, Young-Eun; Lee, Jung-Eun; Chun, Jaemoo; Park, Seonghwan; Jung, Jeeyoun; Park, Min-Cheol.
+Institution
+ Son, Mi Ju. Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon.
+ Yang, Geum-Jin. Korean Medicine Dermatology Clinical Research Center of Wonkwang University, Iksan.
+ Jo, Eun-Heui. Department of Acupuncture and Moxibustion, Jeonju Hospital of Oriental Medicine of Wonkwang University, Jeonju.
+ Shim, Yu-Hwa. Korean Medicine Dermatology Clinical Research Center of Wonkwang University, Iksan.
+ Kang, Su-Jin. Department of Korean Medicine Obstetrics & Gynecology, Wonkwang University Iksan Korean Medicine Hospital, Iksan.
+ Hong, Ji-Eun. Department of Acupuncture and Moxibustion, Jeonju Hospital of Oriental Medicine of Wonkwang University, Jeonju.
+ Kim, Young-Eun. Future Medicine Division, Korea Institute of Oriental Medicine, Daejeon.
+ Lee, Jung-Eun. Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon.
+ Chun, Jaemoo. Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon.
+ Park, Seonghwan. Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon.
+ Jung, Jeeyoun. Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon.
+ Park, Min-Cheol. Department of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, Wonkwang University Iksan Korean Medicine Hospital, Iksan, Republic of Korea.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ Child
+ Child, Preschool
+ *Dermatitis, Atopic/co [Complications]
+ Dermatitis, Atopic/im [Immunology]
+ *Dermatitis, Atopic/me [Metabolism]
+ Dermatitis, Atopic/mi [Microbiology]
+ Eosinophil Cationic Protein/bl [Blood]
+ Feces/ch [Chemistry]
+ Feces/mi [Microbiology]
+ Female
+ Gastrointestinal Microbiome
+ Humans
+ Immunoglobulin E/bl [Blood]
+ Male
+ Metabolome
+ *Obesity/co [Complications]
+ Obesity/im [Immunology]
+ *Obesity/me [Metabolism]
+ Obesity/mi [Microbiology]
+ Quality of Life
+ Republic of Korea
+Abstract
+ INTRODUCTION: Several studies have found that obesity is associated with atopic dermatitis (AD); however, the mechanisms underlying the association are largely unknown. This study aims to assess the association of AD with obesity in the Korean population and verify its mechanism via a multi-omics analysis.
+
+ METHODS AND ANALYSIS: A case-control study will be conducted in the Republic of Korea. A total of 80 subjects, aged 4 to 12 years, matched for age and sex, with body mass index at or above the 85th percentile or at or below the 25th percentile, will be included. Subjects will be assigned to the following 4 groups: obese/overweight with AD, normal/underweight with AD, obese/overweight control, and normal/underweight control. Serum metabolome and immune biomarkers, as well as fecal metabolome and microbiome biomarkers, will be analyzed. Serum eosinophil cationic protein, total serum Immunoglobulin E (IgE), and specific IgE will be analyzed to assess allergic tendency. The SCORing of AD index, the children's dermatology life quality index, body composition analysis, and the Korean gastrointestinal symptom rating scale will be obtained to assess the disease status and severity of the subjects.
+
+ DISCUSSION: The findings of this study are expected to provide evidence of an association between AD and obesity via a gut microbiome-metabolome-immune mechanism. Therefore, it may improve future management strategies for AD.
+
+ TRIAL REGISTRATION: This study has been registered at the Korean National Clinical Trial Registry, Clinical Research Information Service (KCT0003630).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 37341-29-0 (Immunoglobulin E). EC 3-1-27 (Eosinophil Cationic Protein). EC 3-1-27 (RNASE3 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fMD.0000000000016527
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Son&issn=0025-7974&title=Medicine&atitle=Association+of+atopic+dermatitis+with+obesity+via+a+multi-omics+approach%3A+A+protocol+for+a+case-control+study.&volume=98&issue=29&spage=e16527&epage=&date=2019&doi=10.1097%2FMD.0000000000016527&pmid=31335732&sid=OVID:medline
+
+<1579>
+Unique Identifier
+ 31332276
+Title
+ Inter-generational link of obesity in term and preterm births: role of maternal plasma acylcarnitines.
+Source
+ International Journal of Obesity. 43(10):1967-1977, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang G; Sun Q; Liang L; Clash C; Zhang C; Hong X; Ji Y; Radovick S; Pearson C; Bartell TR; Zuckerman B; Cheng TL; Hu FB; Wang X
+Author NameID
+ Liang, Liming; ORCID: http://orcid.org/0000-0001-8261-3174
+ Clash, Clary; ORCID: http://orcid.org/0000-0001-8259-9245
+Authors Full Name
+ Wang, Guoying; Sun, Qi; Liang, Liming; Clash, Clary; Zhang, Cuilin; Hong, Xiumei; Ji, Yuelong; Radovick, Sally; Pearson, Colleen; Bartell, Tami R; Zuckerman, Barry; Cheng, Tina L; Hu, Frank B; Wang, Xiaobin.
+Institution
+ Wang, Guoying. Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
+ Sun, Qi. Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Sun, Qi. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
+ Liang, Liming. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Liang, Liming. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Clash, Clary. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
+ Zhang, Cuilin. Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
+ Zhang, Cuilin. Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
+ Hong, Xiumei. Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
+ Ji, Yuelong. Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
+ Radovick, Sally. Department of Pediatrics, The Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
+ Pearson, Colleen. Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA.
+ Bartell, Tami R. Mary Ann & J. Milburn Smith Child Health Research, Outreach and Advocacy Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
+ Zuckerman, Barry. Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA.
+ Cheng, Tina L. Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
+ Hu, Frank B. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fhu@hsph.harvard.edu.
+ Hu, Frank B. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. fhu@hsph.harvard.edu.
+ Wang, Xiaobin. Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. xwang82@jhu.edu.
+ Wang, Xiaobin. Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. xwang82@jhu.edu.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Boston/ep [Epidemiology]
+ *Carnitine/aa [Analogs & Derivatives]
+ Carnitine/bl [Blood]
+ Child
+ Child, Preschool
+ Female
+ Humans
+ Infant
+ Infant, Newborn
+ Male
+ Mothers/ed [Education]
+ Mothers/sn [Statistics & Numerical Data]
+ *Mothers
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Pediatric Obesity/bl [Blood]
+ Pediatric Obesity/ep [Epidemiology]
+ Pediatric Obesity/et [Etiology]
+ Pregnancy
+ *Premature Birth/bl [Blood]
+ *Prenatal Exposure Delayed Effects/bl [Blood]
+ Prospective Studies
+Abstract
+ BACKGROUND/OBJECTIVES: Acylcarnitines, intermediates of fatty acid oxidation, are known to be involved in obesity and insulin resistance. Since maternal prepregnancy overweight or obesity (OWO) is a recognized major risk factor for offspring OWO, we hypothesized that maternal plasma acylcarnitines may play a role in inter-generational OWO.
+
+ SUBJECTS/METHODS: This study included 1402 mother-child pairs (1043 term, 359 preterm) recruited at birth from 1998-2013 and followed prospectively up to age 18 years at the Boston Medical Center. The primary outcomes were child OWO defined as BMI >= 85th percentile for age and sex. The primary exposures were maternal prepregnancy OWO defined as BMI >= 25 kg/m2 and maternal acylcarnitine levels measured in plasma samples collected soon after delivery using liquid chromatography-tandem mass spectrometry (LC-MS) in a targeted manner.
+
+ RESULTS: Approximately 40% of the children in this study were OWO by age 5. Maternal OWO had a significant association with childhood OWO, both in term and preterm births. beta-hydroxybutyryl-carnitine (C4-OH) levels were significantly and positively associated with child OWO among term births after adjustment for potential confounders and multiple-comparisons. Children born to OWO mothers in the top tertile C4-OH levels were at the highest risk of OWO: OR = 3.78 (95%CI: 2.47, 5.79) as compared with those born to non-OWO mothers in the lowest tertile (P for interaction of maternal OWO and C4-OH = 0.035). In a four-way decomposition of mediation/interaction analysis, we estimated that C4-OH levels explained about 27% (se = 0.08) of inter-generational OWO risk (P = 0.001). In contrast, these associations were not observed in preterm births.
+
+ CONCLUSIONS: In this U.S. urban low-income birth cohort, we provide further evidence of the inter-generational link of OWO and reveal the differential role of C4-OH in explaining the inter-generational obesity between term and preterm births. Further investigations are warranted to better understand and prevent the inter-generational transmission of OWO.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (acylcarnitine). S7UI8SM58A (Carnitine).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural. Research Support, U.S. Gov't, P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-019-0417-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Inter-generational+link+of+obesity+in+term+and+preterm+births%3A+role+of+maternal+plasma+acylcarnitines.&volume=43&issue=10&spage=1967&epage=1977&date=2019&doi=10.1038%2Fs41366-019-0417-x&pmid=31332276&sid=OVID:medline
+
+<1580>
+Unique Identifier
+ 31330300
+Title
+ Inflammatory biomarkers and brain health indicators in children with overweight and obesity: The ActiveBrains project.
+Source
+ Brain, Behavior, & Immunity. 81:588-597, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adelantado-Renau M; Esteban-Cornejo I; Rodriguez-Ayllon M; Cadenas-Sanchez C; Gil-Cosano JJ; Mora-Gonzalez J; Solis-Urra P; Verdejo-Roman J; Aguilera CM; Escolano-Margarit MV; Verdejo-Garcia A; Catena A; Moliner-Urdiales D; Ortega FB
+Authors Full Name
+ Adelantado-Renau, Mireia; Esteban-Cornejo, Irene; Rodriguez-Ayllon, Maria; Cadenas-Sanchez, Cristina; Gil-Cosano, Jose Juan; Mora-Gonzalez, Jose; Solis-Urra, Patricio; Verdejo-Roman, Juan; Aguilera, Concepcion M; Escolano-Margarit, Maria Victoria; Verdejo-Garcia, Antonio; Catena, Andres; Moliner-Urdiales, Diego; Ortega, Francisco B.
+Institution
+ Adelantado-Renau, Mireia. LIFE Research Group, University Jaume I, Castellon, Spain. Electronic address: adelantm@uji.es.
+ Esteban-Cornejo, Irene. PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain; Center for Cognitive and Brain Health, Department of Psychology, Northeastern University, Boston, MA, USA.
+ Rodriguez-Ayllon, Maria. PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain.
+ Cadenas-Sanchez, Cristina. PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain.
+ Gil-Cosano, Jose Juan. PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain.
+ Mora-Gonzalez, Jose. PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain.
+ Solis-Urra, Patricio. PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain; IRyS Research Group, School of Physical Education, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile.
+ Verdejo-Roman, Juan. Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology (CTB), Madrid, Spain; Mind, Brain, and Behavior Research Center-CIMCYC, University of Granada, Granada, Spain.
+ Aguilera, Concepcion M. Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center for Biomedical Research, University of Granada, Granada, Spain; CIBER Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Madrid, Spain; Instituto de Investigacion Biosanitaria ibs, Granada, Spain.
+ Escolano-Margarit, Maria Victoria. Hospital Universitario San Cecilio, Granada, Spain.
+ Verdejo-Garcia, Antonio. School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
+ Catena, Andres. Department of Experimental Psychology, Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain.
+ Moliner-Urdiales, Diego. LIFE Research Group, University Jaume I, Castellon, Spain.
+ Ortega, Francisco B. PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
+MeSH Subject Headings
+ *Academic Success
+ Biomarkers/bl [Blood]
+ Brain/me [Metabolism]
+ Brain/pa [Pathology]
+ *Brain/pp [Physiopathology]
+ C-Reactive Protein/an [Analysis]
+ Child
+ Cross-Sectional Studies
+ Emotional Intelligence/ph [Physiology]
+ Executive Function/ph [Physiology]
+ Female
+ Gray Matter/me [Metabolism]
+ Gray Matter/pa [Pathology]
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/pa [Pathology]
+ Inflammation/pp [Physiopathology]
+ Interleukin-6/bl [Blood]
+ Leukocyte Count
+ Magnetic Resonance Imaging/mt [Methods]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ Obesity/pp [Physiopathology]
+ *Pediatric Obesity/bl [Blood]
+ Pediatric Obesity/pa [Pathology]
+ Pediatric Obesity/pp [Physiopathology]
+ Randomized Controlled Trials as Topic
+ White Matter/me [Metabolism]
+ White Matter/pa [Pathology]
+Keyword Heading
+ Adaptive functioning
+ Brain structure
+ Cognition
+ Inflammation
+ Mental health
+ School performance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Chronic inflammation plays an important role on the pathogenesis of several cardiovascular and metabolic diseases, as well as on brain function and behaviour. The aim of the present study was to examine the associations between inflammatory biomarkers and a wide range of brain health indicators (i.e., academic performance, executive function, behavioural and emotional functioning, and brain volume) in children with overweight/obesity.
+
+ METHODS: A total of 107 children (10.0+/-1.1years, 41% girls) from the ActiveBrains project were included in the analysis. Five inflammatory biomarkers were analysed in plasma: white blood cell (WBC) count, interleukin-6 (IL-6), interleukin-1beta, tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP). Academic performance was assessed by Woodcock-Munoz Tests of Achievement. Executive function was assessed through the Design Fluency Test for cognitive flexibility, the Stroop test for cognitive inhibition, and the Delayed Non-Match-to-Sample task for working memory. Behavioural and emotional functioning was evaluated through the Behavior Assessment System for Children (BASC) questionnaire. Total and regional brain volume was assessed by magnetic resonance imaging.
+
+ RESULTS: IL-6 was inversely associated with adaptive skills (beta=-0.228; p=0.030), while TNF-alpha was related to mathematics (beta=-0.198; p=0.034). In addition, CRP was positively associated with externalizing (beta=0.246; p=0.046) and internalizing problems (beta=0.234; p=0.039), as well as the behavioural symptoms index (beta=0.236; p=0.047). However, these significant associations disappeared after multiple comparisons correction. Inflammatory biomarkers were not associated with executive function and total brain volumes. Regarding regional brain analyses, WBC was positively associated with gray matter volume in the left middle temporal gyrus (beta=0.387; p<0.001, k=44), and CRP was positively associated with gray matter volume in the right superior temporal gyrus (beta=0.439; p<0.001, k=29). Additionally, when adjusting by total brain volume, CRP was positively associated with gray matter volume in the right supplementary motor cortex (beta=0.453; p<0.001, k=51). Moreover, both, IL-6 (beta=0.366; p<0.001, k=81) and TNF-alpha (beta=0.368; p<0.001, k=62) were positively associated with white matter volume around the right inferior frontal gyrus pars opercularis, while CRP was inversely associated with white matter volume around the left superior frontal gyrus (beta=-0.482; p<0.001, k=82). After adjusting by total brain volume, CRP was also inversely associated with white matter volume in 3 additional clusters (beta ranging from -0.473 to -0.404; p<0.001, k=87).
+
+ CONCLUSIONS: Inflammation was slightly associated with brain health (i.e., academic performance, behavioural and emotional functioning and regional brain volume) in children with overweight or obesity. Further larger longitudinal and interventional studies are warranted to elucidate the short-term and long-term effect of systemic low-grade inflammation on children's brain health. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.bbi.2019.07.020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adelantado-Renau&issn=0889-1591&title=Brain%2C+Behavior%2C+%26+Immunity&atitle=Inflammatory+biomarkers+and+brain+health+indicators+in+children+with+overweight+and+obesity%3A+The+ActiveBrains+project.&volume=81&issue=&spage=588&epage=597&date=2019&doi=10.1016%2Fj.bbi.2019.07.020&pmid=31330300&sid=OVID:medline
+
+<1581>
+Unique Identifier
+ 31326727
+Title
+ Liraglutide in combination with metformin may improve the atherogenic lipid profile and decrease C-reactive protein level in statin treated obese patients with coronary artery disease and newly diagnosed type 2 diabetes: A randomized trial.
+Source
+ Atherosclerosis. 288:60-66, 2019 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Anholm C; Kumarathurai P; Pedersen LR; Samkani A; Walzem RL; Nielsen OW; Kristiansen OP; Fenger M; Madsbad S; Sajadieh A; Haugaard SB
+Authors Full Name
+ Anholm, Christian; Kumarathurai, Preman; Pedersen, Lene Rorholm; Samkani, Amirsalar; Walzem, Rosemary L; Nielsen, Olav Wendelboe; Kristiansen, Ole Peter; Fenger, Mogens; Madsbad, Sten; Sajadieh, Ahmad; Haugaard, Steen Bendix.
+Institution
+ Anholm, Christian. Department of Internal Medicine, Copenhagen University Hospital, Glostrup, Denmark; Department of Internal Medicine, Copenhagen University Hospital, Amager, Denmark. Electronic address: canholm@youmail.dk.
+ Kumarathurai, Preman. Department of Cardiology, Copenhagen University Hospital, Bispebjerg, Denmark.
+ Pedersen, Lene Rorholm. Department of Cardiology, Copenhagen University Hospital, Bispebjerg, Denmark.
+ Samkani, Amirsalar. Department of Endocrinology, Copenhagen University Hospital, Bispebjerg, Denmark.
+ Walzem, Rosemary L. Department of Poultry Science and Faculty of Nutrition, Texas A&M University, Texas, USA.
+ Nielsen, Olav Wendelboe. Department of Cardiology, Copenhagen University Hospital, Bispebjerg, Denmark.
+ Kristiansen, Ole Peter. Department of Cardiology, Copenhagen University Hospital, Bispebjerg, Denmark.
+ Fenger, Mogens. Department of Clinical Biochemistry, Copenhagen University Hospital, Hvidovre, Denmark.
+ Madsbad, Sten. Department of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark.
+ Sajadieh, Ahmad. Department of Cardiology, Copenhagen University Hospital, Bispebjerg, Denmark.
+ Haugaard, Steen Bendix. Department of Internal Medicine, Copenhagen University Hospital, Amager, Denmark; Department of Endocrinology, Copenhagen University Hospital, Bispebjerg, Denmark.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *C-Reactive Protein/me [Metabolism]
+ Coronary Artery Disease/bl [Blood]
+ Coronary Artery Disease/dg [Diagnostic Imaging]
+ *Coronary Artery Disease/dt [Drug Therapy]
+ Cross-Over Studies
+ Denmark
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Double-Blind Method
+ Drug Therapy, Combination
+ Female
+ Humans
+ Hydroxymethylglutaryl-CoA Reductase Inhibitors/ae [Adverse Effects]
+ *Hydroxymethylglutaryl-CoA Reductase Inhibitors/tu [Therapeutic Use]
+ Hypoglycemic Agents/ae [Adverse Effects]
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ *Inflammation Mediators/bl [Blood]
+ *Lipids/bl [Blood]
+ Liraglutide/ae [Adverse Effects]
+ *Liraglutide/tu [Therapeutic Use]
+ Male
+ Metformin/ae [Adverse Effects]
+ *Metformin/tu [Therapeutic Use]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ GLP-1
+ Lipoprotein
+ Liraglutide
+ Low-grade inflammation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Atherosclerosis in obesity and type 2 diabetes (T2DM) is associated with low-grade inflammation (LGI) and dyslipidemia, where especially small, dense lipoprotein particles are atherogenic. The glucagon-like peptide-1 receptor agonist, liraglutide, reduces cardiovascular events by poorly understood mechanisms. We investigated the effect of liraglutide combined with metformin on LGI and lipoprotein density profiles in patients with stable coronary artery disease (CAD) and newly diagnosed T2DM.
+
+ METHODS: We conducted a randomized, double-blind, placebo-controlled, cross-over trial over a 12 + 12-week period, with >=2-week wash-out.
+
+ INTERVENTION: liraglutide/metformin vs. placebo/metformin. Lipoproteins were separated by continuous density gradient ultracentrifugation, and LDL divided into five subfractions between 226 and 270A, considering particle size <=255A as the atherogenic pattern. Plasma C-reactive protein and tumor necrosis factor-alpha were assessed by the enzyme-linked immunosorbent-assay.
+
+ RESULTS: 28 out of 41 randomized patients completed all visits. Intention-to-treat analysis was performed but one patient had statin dosage and was excluded from the analysis. 95% of the patients were on statin therapy. Overall, liraglutide did not affect lipid subfractions or markers of LGI compared to placebo. The combination of liraglutide and metformin reduced the total LDL subfractions, primarily by reducing the most atherogenic subfraction LDL5, and reduced CRP but not TNF-alpha. Explorative analyses suggested that the subfraction LDL5 during the wash-out period rebounded significantly at least in a per-protocol analysis of the sub-group of patients starting the liraglutide therapy.
+
+ CONCLUSIONS: In patients with CAD and newly diagnosed T2DM on stable statin therapy, liraglutide combined with metformin may improve the atherogenic LDL lipid profile and CRP. Copyright © 2019 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors). 0 (Hypoglycemic Agents). 0 (Inflammation Mediators). 0 (Lipids). 839I73S42A (Liraglutide). 9007-41-4 (C-Reactive Protein). 9100L32L2N (Metformin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.atherosclerosis.2019.07.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Anholm&issn=0021-9150&title=Atherosclerosis&atitle=Liraglutide+in+combination+with+metformin+may+improve+the+atherogenic+lipid+profile+and+decrease+C-reactive+protein+level+in+statin+treated+obese+patients+with+coronary+artery+disease+and+newly+diagnosed+type+2+diabetes%3A+A+randomized+trial.&volume=288&issue=&spage=60&epage=66&date=2019&doi=10.1016%2Fj.atherosclerosis.2019.07.007&pmid=31326727&sid=OVID:medline
+
+<1582>
+Unique Identifier
+ 31323907
+Title
+ Ketogenic Diet-Induced Weight Loss is Associated with an Increase in Vitamin D Levels in Obese Adults.
+Source
+ Molecules. 24(13), 2019 Jul 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Perticone M; Maio R; Sciacqua A; Suraci E; Pinto A; Pujia R; Zito R; Gigliotti S; Sesti G; Perticone F
+Author NameID
+ Perticone, Maria; ORCID: https://orcid.org/0000-0002-2456-1123
+ Pinto, Angelina; ORCID: https://orcid.org/0000-0003-0792-3046
+ Sesti, Giorgio; ORCID: https://orcid.org/0000-0002-1618-7688
+ Perticone, Francesco; ORCID: https://orcid.org/0000-0003-2402-0981
+Authors Full Name
+ Perticone, Maria; Maio, Raffaele; Sciacqua, Angela; Suraci, Edoardo; Pinto, Angelina; Pujia, Roberta; Zito, Roberta; Gigliotti, Simona; Sesti, Giorgio; Perticone, Francesco.
+Institution
+ Perticone, Maria. Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. mariaperticone@hotmail.com.
+ Maio, Raffaele. Azienda Ospedaliero, Universitaria Mater Domini di Catanzaro, 88100 Catanzaro, Italy.
+ Sciacqua, Angela. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+ Suraci, Edoardo. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+ Pinto, Angelina. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+ Pujia, Roberta. Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+ Zito, Roberta. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+ Gigliotti, Simona. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+ Sesti, Giorgio. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+ Perticone, Francesco. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Diet, Ketogenic/ae [Adverse Effects]
+ *Diet, Ketogenic
+ Female
+ Hemodynamics
+ Humans
+ Male
+ Middle Aged
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Vitamin D/bl [Blood]
+ *Vitamin D/me [Metabolism]
+ *Weight Loss
+Keyword Heading
+ ketogenic diet
+ obesity
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Vitamin D is an important micronutrient involved in several processes. Evidence has shown a strong association between hypovitaminosis D and cardio-metabolic diseases, including obesity. A ketogenic diet has proven to be very effective for weight loss, especially in reducing fat mass while preserving fat-free mass. The aim of this study was to investigate the effect of a ketogenic diet-induced weight loss on vitamin D status in a population of obese adults. We enrolled 56 obese outpatients, prescribed with either traditional standard hypocaloric Mediterranean diet (SHMD) or very low-calorie ketogenic diet (VLCKD). Serum 25(OH)D concentrations were measured by chemiluminescence. The mean value of serum 25-hydroxyvitamin D (25(OH)D) concentrations in the whole population at baseline was 17.8 +/- 5.6 ng/mL, without differences between groups. After 12 months of dietetic treatment, in VLCKD patients serum 25(OH)D concentrations increased from 18.4 +/- 5.9 to 29.3 +/- 6.8 ng/mL (p < 0.0001), vs 17.5 +/- 6.1 to 21.3 +/- 7.6 ng/mL (p = 0.067) in the SHMD group (for each kilogram of weight loss, 25(OH)D concentration increased 0.39 and 0.13 ng/mL in the VLCKD and in the SHMD groups, respectively). In the VLCKD group, the increase in serum 25(OH)D concentrations was strongly associated with body mass index, waist circumference, and fatty mass variation. In a multiple regression analysis, fatty mass was the strongest independent predictor of serum 25(OH)D concentration, explaining 15.6%, 3.3%, and 9.4% of its variation in the whole population, in SHMD, and VLCKD groups, respectively. We also observed a greater reduction of inflammation (evaluated by high-sensitivity C reactive protein (hsCRP) values) and a greater improvement in glucose homeostasis, confirmed by a reduction of HOMA values, in the VLCKD versus the SHMD group. Taken together, all these data suggest that a dietetic regimen, which implies a great reduction of fat mass, can improve vitamin D status in the obese.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fmolecules24132499
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Perticone&issn=1420-3049&title=Molecules&atitle=Ketogenic+Diet-Induced+Weight+Loss+is+Associated+with+an+Increase+in+Vitamin+D+Levels+in+Obese+Adults.&volume=24&issue=13&spage=2499&epage=&date=2019&doi=10.3390%2Fmolecules24132499&pmid=31323907&sid=OVID:medline
+
+<1583>
+Unique Identifier
+ 31323006
+Title
+ Association of the 3'UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 32(9):921-928, 2019 Sep 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ruiz-Padilla AJ; Morales-Hernandez G; Ruiz-Noa Y; Alonso-Castro AJ; Lazo-de-la-Vega-Monroy ML; Preciado-Puga MDC; Rangel-Salazar R; Ibarra-Reynoso LDR
+Authors Full Name
+ Ruiz-Padilla, Alan Joel; Morales-Hernandez, Gerardo; Ruiz-Noa, Yeniley; Alonso-Castro, Angel Josabad; Lazo-de-la-Vega-Monroy, Maria Luisa; Preciado-Puga, Monica Del Carmen; Rangel-Salazar, Ruben; Ibarra-Reynoso, Lorena Del Rocio.
+Institution
+ Ruiz-Padilla, Alan Joel. Department of Pharmacy, Natural and Exact Sciences Division, University of Guanajuato, Guanajuato Campus, Guanajuato, Gto, Mexico.
+ Morales-Hernandez, Gerardo. Department of Planning Subdirection, General Hospital of Leon, Leon, Gto, Mexico.
+ Ruiz-Noa, Yeniley. Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, Leon, Mexico.
+ Alonso-Castro, Angel Josabad. Department of Pharmacy, Natural and Exact Sciences Division, University of Guanajuato, Guanajuato Campus, Guanajuato, Gto, Mexico.
+ Lazo-de-la-Vega-Monroy, Maria Luisa. Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, Leon, Mexico.
+ Preciado-Puga, Monica Del Carmen. Department of Medicine and Nutrition, Health Sciences Division, University of Guanajuato, Leon Campus, Leon, Gto, Mexico.
+ Rangel-Salazar, Ruben. Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, Leon, Mexico.
+ Ibarra-Reynoso, Lorena Del Rocio. Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, Leon, Mexico.
+MeSH Subject Headings
+ *3' Untranslated Regions/ge [Genetics]
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ Child
+ Cross-Sectional Studies
+ Energy Intake
+ Female
+ *Fibroblast Growth Factors/ge [Genetics]
+ Follow-Up Studies
+ Humans
+ Insulin Resistance
+ Lipids
+ Male
+ *Nutrients/me [Metabolism]
+ *Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ *Obesity/pa [Pathology]
+ *Polymorphism, Genetic
+ Prognosis
+Keyword Heading
+ FGF21
+ genetic variants
+ nutrient intake
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Fibroblast growth factor 21 (FGF21) is considered an important regulator of lipid and glucose metabolism. However, the role of FGF21 in macronutrient intake and metabolic disease, particularly in pediatric population, still needs further clarification. This study aimed to evaluate the association of rs11665896 in the FGF21 gene with metabolic status and macronutrient intake in a cohort of Mexican children with obesity. Methods Eighty-four lean children and 113 children with obesity, from 8 to 11 years of age, were recruited. FGF21 rs11665896 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Somatometric evaluations, nutrient intake, glucose, lipids, insulin and FGF21 serum levels were measured in the obesity group. Results The T allele of rs11665896 in the FGF21 gene was associated with obesity (odds ratio [OR] = 1.99, 95% confidence interval [CI] = 1.14-3.46; p = 0.0151). Subjects with obesity carrying the TT genotype consumed less lipids and more carbohydrates compared to other genotypes. Circulating FGF21 levels correlated negatively with carbohydrate intake (r = -0.232, p = 0.022) and positively with body weight (r = 0.269, p = 0.007), waist (r = 0.242, p = 0.016) and hip girth (r = 0.204, p = 0.042). FGF21 levels were lower in carriers of at least one T allele. Conclusions Genetic variants in FGF21 could influence metabolic status, food preferences and qualitative changes in nutritional behavior in children.
+Registry Number/Name of Substance
+ 0 (3' Untranslated Regions). 0 (Biomarkers). 0 (Lipids). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fjpem-2018-0546
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ruiz-Padilla&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Association+of+the+3%27UTR+polymorphism+%28rs11665896%29+in+the+FGF21+gene+with+metabolic+status+and+nutrient+intake+in+children+with+obesity.&volume=32&issue=9&spage=921&epage=928&date=2019&doi=10.1515%2Fjpem-2018-0546&pmid=31323006&sid=OVID:medline
+
+<1584>
+Unique Identifier
+ 31317460
+Title
+ Apneic Oxygenation During Prolonged Laryngoscopy in Obese Patients: a Randomized, Double-Blinded, Controlled Trial of Nasal Cannula Oxygen Administration.
+Source
+ Obesity Surgery. 29(12):3992-3999, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moon TS; Tai K; Kim A; Gonzales MX; Lu R; Pak T; Smith K; Chen JL; Minhajuddin AT; Nnamani N; Fox PE; Ogunnaike B
+Author NameID
+ Moon, Tiffany S; ORCID: http://orcid.org/0000-0001-7052-5169
+Authors Full Name
+ Moon, Tiffany S; Tai, Katie; Kim, Agnes; Gonzales, Michael X; Lu, Rachael; Pak, Taylor; Smith, Katelynn; Chen, Joy L; Minhajuddin, Abu T; Nnamani, Nwamaka; Fox, Pamela E; Ogunnaike, Babatunde.
+Institution
+ Moon, Tiffany S. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA. Tiffany.Moon@UTSouthwestern.edu.
+ Tai, Katie. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Kim, Agnes. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Gonzales, Michael X. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Lu, Rachael. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Pak, Taylor. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Smith, Katelynn. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Chen, Joy L. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Minhajuddin, Abu T. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Nnamani, Nwamaka. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Fox, Pamela E. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+ Ogunnaike, Babatunde. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
+MeSH Subject Headings
+ Adult
+ Anesthesia, General
+ Apnea/bl [Blood]
+ Apnea/di [Diagnosis]
+ Apnea/et [Etiology]
+ *Apnea/th [Therapy]
+ Biomarkers/bl [Blood]
+ Cannula
+ Double-Blind Method
+ Female
+ Humans
+ *Laryngoscopy
+ Male
+ Middle Aged
+ *Obesity/su [Surgery]
+ Oxygen/bl [Blood]
+ Oxygen Inhalation Therapy/is [Instrumentation]
+ *Oxygen Inhalation Therapy/mt [Methods]
+ Preoperative Care/is [Instrumentation]
+ *Preoperative Care/mt [Methods]
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ Airway management
+ Apneic oxygenation
+ Difficult intubation
+ Laryngoscopy
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obese patients have a propensity to desaturate during induction of general anesthesia secondary to their reduced functional residual capacity and increased oxygen consumption. Apneic oxygenation can provide supplemental oxygen to the alveoli, even in the absence of ventilation, during attempts to secure the airway. In this study, we hypothesized that oxygen administration through a nasopharyngeal airway and standard nasal cannula during a simulated prolonged laryngoscopy would significantly prolong the safe apneic duration in obese patients.
+
+ METHODS: One hundred thirty-five obese patients undergoing non-emergent surgery requiring general anesthesia were randomized to either the control group or to receive apneic oxygenation with air versus oxygen. All patients underwent a standard intravenous induction. For patients randomized to receive apneic oxygenation, a nasopharyngeal airway and standard nasal cannula were inserted. A simulated prolonged laryngoscopy was performed to determine the duration of the safe apneic period, defined as the beginning of laryngoscopy until the peripheral oxygen saturation (SpO2) reached 95%.
+
+ RESULTS: The oxygen group had a median safe apneic duration that was 103 s longer than the control group. The lowest mean SpO2 value during the induction period was 3.8% higher in the oxygen group compared to the control group. Following intubation, patients in the oxygen group had a mean end tidal carbon dioxide (ETCO2) level that was 3.0 mmHg higher than patients in the control group.
+
+ CONCLUSIONS: In obese patients, oxygen insufflation at 15 L/min through a nasopharyngeal airway and standard nasal cannula can significantly increase the safe apneic duration during induction of anesthesia.
+Registry Number/Name of Substance
+ 0 (Biomarkers). S88TT14065 (Oxygen).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11695-019-04077-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moon&issn=0960-8923&title=Obesity+Surgery&atitle=Apneic+Oxygenation+During+Prolonged+Laryngoscopy+in+Obese+Patients%3A+a+Randomized%2C+Double-Blinded%2C+Controlled+Trial+of+Nasal+Cannula+Oxygen+Administration.&volume=29&issue=12&spage=3992&epage=3999&date=2019&doi=10.1007%2Fs11695-019-04077-y&pmid=31317460&sid=OVID:medline
+
+<1585>
+Unique Identifier
+ 31307852
+Title
+ The number and phenotype of myocardial and adipose tissue CD68+ cells is associated with cardiovascular and metabolic disease in heart surgery patients.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 29(9):946-955, 2019 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pierzynova A; Sramek J; Cinkajzlova A; Kratochvilova H; Lindner J; Haluzik M; Kucera T
+Authors Full Name
+ Pierzynova, Aneta; Sramek, Jaromir; Cinkajzlova, Anna; Kratochvilova, Helena; Lindner, Jaroslav; Haluzik, Martin; Kucera, Tomas.
+Institution
+ Pierzynova, Aneta. Institute of Histology and Embryology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
+ Sramek, Jaromir. Institute of Histology and Embryology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
+ Cinkajzlova, Anna. Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Department of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
+ Kratochvilova, Helena. Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Department of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
+ Lindner, Jaroslav. 2nd Department of Surgery - Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
+ Haluzik, Martin. Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Department of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
+ Kucera, Tomas. Institute of Histology and Embryology, First Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: tkucer@lf1.cuni.cz.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ *Antigens, CD/an [Analysis]
+ *Antigens, Differentiation, Myelomonocytic/an [Analysis]
+ Biomarkers/an [Analysis]
+ CD11c Antigen/an [Analysis]
+ Case-Control Studies
+ Cell Count
+ Coronary Artery Disease/im [Immunology]
+ *Coronary Artery Disease/pa [Pathology]
+ Diabetes Mellitus, Type 2/im [Immunology]
+ *Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Humans
+ Inflammation/im [Immunology]
+ *Inflammation/pa [Pathology]
+ Macrophages/im [Immunology]
+ *Macrophages/pa [Pathology]
+ Male
+ Middle Aged
+ Myocardium/im [Immunology]
+ *Myocardium/pa [Pathology]
+ Obesity/im [Immunology]
+ *Obesity/pa [Pathology]
+ Phenotype
+ Subcutaneous Fat/im [Immunology]
+ *Subcutaneous Fat/pa [Pathology]
+Keyword Heading
+ Coronary artery disease
+ Crown-like structures
+ Epicardium
+ Macrophages
+ Myocardium
+ Obesity
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: CD68+ cells are a potent source of inflammatory cytokines in adipose tissue and myocardium. The development of low-grade inflammation in adipose tissue is implicated in the pathogenesis of obesity-associated disorders including type 2 diabetes mellitus (T2DM) and cardiovascular disease. The main aim of the study was to characterize and quantify myocardial and adipose tissue CD68+ cells and adipose tissue crown-like structures (CLS) in patients with obesity, coronary artery disease (CAD) and T2DM.
+
+ METHODS AND RESULTS: Samples were obtained from the right atrium, epicardial (EAT) and subcutaneous adipose tissue (SAT) during elective heart surgery (non-obese, n = 34 patients; obese, n = 24 patients). Immunohistochemistry was used to visualize CD68+ cells. M1-polarized macrophages were visualized by immunohistochemical detection of CD11c. The proportion of CD68+ cells was higher in EAT than in SAT (43.4 +/- 25.0 versus 32.5 +/- 23.1 cells per 1 mm2; p = 0.015). Myocardial CD68+ cells were more abundant in obese patients (45.6 +/- 24.5 versus 27.7 +/- 14.8 cells per 1 mm2; p = 0.045). In SAT, CD68+ cells were more frequent in CAD patients (37.3 +/- 23.0 versus 23.1 +/- 20.9 cells per 1 mm2; p = 0.012). Patients having CLS in their SAT had higher average BMI (34.1 +/- 6.4 versus 29.0 +/- 4.5; p = 0.024).
+
+ CONCLUSIONS: Regional-based increases in the frequency of CD68+ cells and changes of their phenotype in CLS were detected in obese patients and CAD patients. Therapeutic modulation of adipose tissue inflammation may represent a target for treatment of obesity. Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antigens, CD). 0 (Antigens, Differentiation, Myelomonocytic). 0 (Biomarkers). 0 (CD11c Antigen). 0 (CD68 antigen, human).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.numecd.2019.05.063
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pierzynova&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=The+number+and+phenotype+of+myocardial+and+adipose+tissue+CD68%2B+cells+is+associated+with+cardiovascular+and+metabolic+disease+in+heart+surgery+patients.&volume=29&issue=9&spage=946&epage=955&date=2019&doi=10.1016%2Fj.numecd.2019.05.063&pmid=31307852&sid=OVID:medline
+
+<1586>
+Unique Identifier
+ 31305133
+Title
+ Role of microRNA in the Pathogenesis of Polycystic Ovary Syndrome.
+Source
+ DNA & Cell Biology. 38(8):754-762, 2019 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen Z; Ou H; Wu H; Wu P; Mo Z
+Authors Full Name
+ Chen, Zhuo; Ou, Hanxiao; Wu, Hongliang; Wu, Peng; Mo, Zhongcheng.
+Institution
+ Chen, Zhuo. 1YueYang Maternal-Child Medicine Health Hospital, Hunan Province Innovative Training Base for Medical Postgraduates, University of South China and Yueyang Women & Children's Medical Center, Yueyang, Hunan, P.R. China.
+ Ou, Hanxiao. 1YueYang Maternal-Child Medicine Health Hospital, Hunan Province Innovative Training Base for Medical Postgraduates, University of South China and Yueyang Women & Children's Medical Center, Yueyang, Hunan, P.R. China.
+ Ou, Hanxiao. 2Department of Histology and Embryology, Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, P.R. China.
+ Wu, Hongliang. 1YueYang Maternal-Child Medicine Health Hospital, Hunan Province Innovative Training Base for Medical Postgraduates, University of South China and Yueyang Women & Children's Medical Center, Yueyang, Hunan, P.R. China.
+ Wu, Peng. 1YueYang Maternal-Child Medicine Health Hospital, Hunan Province Innovative Training Base for Medical Postgraduates, University of South China and Yueyang Women & Children's Medical Center, Yueyang, Hunan, P.R. China.
+ Mo, Zhongcheng. 1YueYang Maternal-Child Medicine Health Hospital, Hunan Province Innovative Training Base for Medical Postgraduates, University of South China and Yueyang Women & Children's Medical Center, Yueyang, Hunan, P.R. China.
+ Mo, Zhongcheng. 2Department of Histology and Embryology, Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, P.R. China.
+MeSH Subject Headings
+ Androgens/ge [Genetics]
+ *Androgens/me [Metabolism]
+ *Biomarkers/bl [Blood]
+ Dyslipidemias/ge [Genetics]
+ Female
+ Gene Expression Regulation
+ Humans
+ Insulin Resistance/ge [Genetics]
+ MicroRNAs/bl [Blood]
+ *MicroRNAs
+ Obesity/ge [Genetics]
+ Ovarian Follicle/gd [Growth & Development]
+ Ovarian Follicle/pa [Pathology]
+ Ovary/ph [Physiology]
+ Polycystic Ovary Syndrome/et [Etiology]
+ *Polycystic Ovary Syndrome/ge [Genetics]
+Keyword Heading
+ follicular development
+ hyperandrogenism
+ insulin resistance
+ lipid metabolism
+ microRNA
+ polycystic ovary syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Polycystic ovary syndrome (PCOS) is the most typical metabolic syndrome in women of reproductive age, with a high prevalence and an increased risk of long-term complications. PCOS mainly manifests as hyperandrogenism (HA), ovulatory dysfunction, and polycystic ovaries, in addition to being relevant to infertility, insulin resistance (IR), obesity, lipid abnormalities, and chronic low-grade inflammation. The etiology of this syndrome remains largely unknown. microRNAs (miRNAs), small, noncoding RNAs (nearly 22 nucleotides long), regulate gene expression at the posttranscriptional level. Abnormal miRNA levels are closely associated with the occurrence of diseases, such as diabetes, cancers, and atherosclerosis, and miRNAs can be used as predictors and diagnostic biomarkers for cancer. Interestingly, the roles of miRNAs in PCOS pathology have attracted considerable attention in recent years. Research has established that alterations in miRNA expression in women with PCOS compared with healthy women may act as noninvasive biomarkers and new therapeutic targets in PCOS. This article aims to summarize the latest research on the relationship between miRNAs and the clinical manifestations of PCOS while also providing a few mechanisms based on previous studies. Understanding the relationship between miRNAs and PCOS will provide guidance for researchers to further explore the complexity and heterogeneity of PCOS.
+Registry Number/Name of Substance
+ 0 (Androgens). 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1089%2fdna.2019.4622
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1044-5498&title=DNA+%26+Cell+Biology&atitle=Role+of+microRNA+in+the+Pathogenesis+of+Polycystic+Ovary+Syndrome.&volume=38&issue=8&spage=754&epage=762&date=2019&doi=10.1089%2Fdna.2019.4622&pmid=31305133&sid=OVID:medline
+
+<1587>
+Unique Identifier
+ 31302012
+Title
+ Markers of adipose tissue inflammation are transiently elevated during intermittent fasting in women who are overweight or obese.
+Source
+ Obesity Research & Clinical Practice. 13(4):408-415, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu B; Hutchison AT; Thompson CH; Lange K; Heilbronn LK
+Authors Full Name
+ Liu, Bo; Hutchison, Amy T; Thompson, Campbell H; Lange, Kylie; Heilbronn, Leonie K.
+Institution
+ Liu, Bo. Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia; Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia.
+ Hutchison, Amy T. Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia; Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia.
+ Thompson, Campbell H. Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia.
+ Lange, Kylie. Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia.
+ Heilbronn, Leonie K. Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia; Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia. Electronic address: leonie.heilbronn@adelaide.edu.au.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/me [Metabolism]
+ Caloric Restriction
+ Cytokines/me [Metabolism]
+ Fasting/bl [Blood]
+ Fatty Acids, Nonesterified/me [Metabolism]
+ Female
+ Humans
+ Macrophages/ph [Physiology]
+ Middle Aged
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ Overweight/bl [Blood]
+ *Overweight/dh [Diet Therapy]
+ *Panniculitis/di [Diagnosis]
+ Subcutaneous Fat/me [Metabolism]
+Keyword Heading
+ Adipose tissue
+ Extracellular matrix
+ Inflammation
+ Intermittent fasting
+ Skeletal muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: This study compared the effects of daily calorie restriction (DR) versus intermittent fasting (IF) on markers of inflammation and extracellular matrix deposition in adipose tissue and skeletal muscle in a controlled feeding trial in women with overweight or obesity.
+
+ METHODS: Women (N=76) were randomised to one of three diets and provided with all foods at 100% (IF100) or 70% (IF70 and DR70) of calculated energy requirements for 8weeks. IF groups ate breakfast prior to fasting for 24-h on 3 non-consecutive days/week. Weight, body composition, serum non-esterified fatty acids (NEFA), tumour necrosis factor-alpha (TNFalpha), interleukin-6 (IL-6), interleukin-10 (IL-10), M1- and M2-macrophage markers by qPCR and immunohistochemistry in adipose tissue and skeletal muscle were measured following a 12-h overnight fast (fed day, all groups) and a 24-h fast (IF groups only).
+
+ RESULTS: IF70 resulted in greater weight and fat losses and reductions in serum NEFA versus DR70 and IF100 (P<0.05) after fed days. Markers of inflammation in serum (TNFalpha, IL6 and IL10), subcutaneous adipose tissue and skeletal muscle (CD68, CD40 and CD163) were unchanged by DR or IF after fed days. After fasting, NEFA, M1-macrophages (CD40+) in adipose tissue, and M2-macrophages (CD163+) in muscle were increased in IF70 and IF100 (all P<0.05) and the changes in NEFA and mRNA of pan-macrophage marker CD68 in adipose tissue were positively correlated (r=0.56, P=0.002).
+
+ CONCLUSIONS: Unlike caloric restriction, IF transiently elevated markers of macrophage infiltration in adipose tissue and skeletal muscle, possibly in response to marked increases in adipose tissue lipolysis. Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Fatty Acids, Nonesterified).
+Publication Type
+ Comparative Study. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.orcp.2019.07.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=1871-403X&title=Obesity+Research+%26+Clinical+Practice&atitle=Markers+of+adipose+tissue+inflammation+are+transiently+elevated+during+intermittent+fasting+in+women+who+are+overweight+or+obese.&volume=13&issue=4&spage=408&epage=415&date=2019&doi=10.1016%2Fj.orcp.2019.07.001&pmid=31302012&sid=OVID:medline
+
+<1588>
+Unique Identifier
+ 31299192
+Title
+ Self-reported eating behaviors of military recruits are associated with body mass index at military accession and change during initial military training.
+Source
+ Appetite. 142:104348, 2019 11 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fagnant HS; Armstrong NJ; Lutz LJ; Nakayama AT; Guerriere KI; Ruthazer R; Cole RE; McClung JP; Gaffney-Stomberg E; Karl JP
+Authors Full Name
+ Fagnant, Heather S; Armstrong, Nicholes J; Lutz, Laura J; Nakayama, Anna T; Guerriere, Katelyn I; Ruthazer, Robin; Cole, Renee E; McClung, James P; Gaffney-Stomberg, Erin; Karl, J Philip.
+Institution
+ Fagnant, Heather S. Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA; Oak Ridge Institute for Science and Education, Belcamp, MD, 21017, USA. Electronic address: heather.s.fagnant.ctr@mail.mil.
+ Armstrong, Nicholes J. Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA. Electronic address: Nicholes.j.armstrong.civ@mail.mil.
+ Lutz, Laura J. Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA. Electronic address: laura.j.lutz2.civ@mail.mil.
+ Nakayama, Anna T. Oak Ridge Institute for Science and Education, Belcamp, MD, 21017, USA; Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA. Electronic address: anna.t.nakayama.ctr@mail.mil.
+ Guerriere, Katelyn I. Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA. Electronic address: Katelyn.i.guerriere.civ@mail.mil.
+ Ruthazer, Robin. Tufts University Clinical and Translational Science Institute, Boston, MA, 02111, USA. Electronic address: rruthazer@tuftsmedicalcenter.org.
+ Cole, Renee E. Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA. Electronic address: renee.e.cole.mil@mail.mil.
+ McClung, James P. Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA. Electronic address: james.p.mcclung8.civ@mail.mil.
+ Gaffney-Stomberg, Erin. Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA. Electronic address: Erin.g.stomberg.civ@mail.mil.
+ Karl, J Philip. Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, 01760, USA. Electronic address: james.p.karl.civ@mail.mil.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Body Composition
+ *Body Mass Index
+ Body Weight
+ Diet
+ *Feeding Behavior
+ Female
+ Humans
+ Male
+ *Military Personnel
+ Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ Physical Fitness
+ Satiation
+ *Self Report
+ Surveys and Questionnaires
+ United States
+ Young Adult
+Keyword Heading
+ Basic combat training
+ Eating rate
+ Healthy Eating Index
+ Hunger
+ Satiety
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Eating behaviors such as eating fast and ignoring internal satiety cues are associated with overweight/obesity, and may be influenced by environmental factors. This study examined changes in those behaviors, and associations between those behaviors and BMI, cardiometabolic biomarkers, and diet quality in military recruits before and during initial military training (IMT), an environment wherein access to food is restricted. Eating rate and reliance on internal satiety cues were self-reported, and BMI, body fat, cardiometabolic biomarkers, and diet quality were measured in 1389 Army, Air Force and Marine recruits (45% female, mean+/-SEM BMI=24.1+/-0.1kg/m2) before and after IMT. Pre-IMT, habitually eating fast relative to slowly was associated with a 1.1+/-0.3kg/m2 higher BMI (P<0.001), but not with other outcomes; whereas, habitually eating until no food is left (i.e., ignoring internal satiety cues) was associated with lower diet quality (P<0.001) and, in men, 1.6+/-0.6% lower body fat (P=0.03) relative to those that habitually stopped eating before feeling full. More recruits reported eating fast (82% vs 39%) and a reduced reliance on internal satiety cues (55% vs 16%) during IMT relative to pre-IMT (P<0.001). Findings suggest that eating behaviors correlate with body composition and/or diet quality in young, predominantly normal-weight recruits entering the military, and that IMT is associated with potentially unfavorable changes in these eating behaviors. Copyright Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.appet.2019.104348
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fagnant&issn=0195-6663&title=Appetite&atitle=Self-reported+eating+behaviors+of+military+recruits+are+associated+with+body+mass+index+at+military+accession+and+change+during+initial+military+training.&volume=142&issue=&spage=104348&epage=&date=2019&doi=10.1016%2Fj.appet.2019.104348&pmid=31299192&sid=OVID:medline
+
+<1589>
+Unique Identifier
+ 31297740
+Title
+ One Anastomosis Gastric Bypass/Minigastric Bypass in Patients with BMI < 35 kg/m2 and Type 2 Diabetes Mellitus: Preliminary Report.
+Source
+ Obesity Surgery. 29(12):3987-3991, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Navarrete Aulestia S; Leyba JL; Navarrete Llopis S; Pulgar V
+Author NameID
+ Navarrete Aulestia, Salvador; ORCID: http://orcid.org/0000-0002-2541-7553
+Authors Full Name
+ Navarrete Aulestia, Salvador; Leyba, Jose Luis; Navarrete Llopis, Salvador; Pulgar, Viviana.
+Institution
+ Navarrete Aulestia, Salvador. Universidad Central de Venezuela, Caracas, Venezuela. navarreteasalvador@gmail.com.
+ Leyba, Jose Luis. Universidad Central de Venezuela, Caracas, Venezuela.
+ Navarrete Llopis, Salvador. Cleveland Clinic, Cleveland, OH, USA.
+ Pulgar, Viviana. Hospital Rio Hortega, Valladolid, Spain.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Anastomosis, Surgical
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/su [Surgery]
+ Female
+ Follow-Up Studies
+ *Gastric Bypass/mt [Methods]
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity/su [Surgery]
+ Prospective Studies
+ Severity of Illness Index
+ Treatment Outcome
+ Weight Loss
+ Young Adult
+Keyword Heading
+ Diabetes mellitus
+ Gastric bypass
+ Laparoscopy
+ Metabolic surgery
+ One anastomosis gastric bypass
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity in the world has been increasing, and the number of diabetic patients will increase by 114%, and the best treatment results are achieved through surgery. Several techniques have been described; the gastric bypass of an anastomosis (MGB/OAGB) has been gaining popularity for its simplicity and good results. We present a prospective study with this technique in 16 mild obesity patients with type 2 diabetes mellitus or peripheral insulin resistance.
+
+ OBJECTIVE: To evaluate weight loss as well as metabolic changes by measuring fasting glycemia and Hb A1c after 1 year of follow-up.
+
+ MATERIAL AND METHODS: Sixteen patients were operated on with the OAGB/MGB technique from September 2014 to January 2016, with some form of metabolic syndrome, whether DM2, RPI, HBP, or dyslipidemia, including patients in the study with a follow-up of at least 12 months.
+
+ RESULTS: There were 13 cases of female sex and 3 of male, average age of 42.9 years, with an average weight of 87.7 kg and BMI of 32.2 kg/m2. Metabolic values were fasting glycemia of 193.6 +/- 52.9 mg/dl and HbA1c of 8.4% +/- 1 (preop) and glycemia posop, 78.8 +/- 7.6 mg/dl; HbA1c posop, 6.1 +/- 0.2; preop weight, 87.7 +/- 14 kg (69-116); weight posop, 66.8 +/- 10.5 kg (49-90); BMI preop, 32.2 +/- 1.8 (30-34.9); BMI posop, 25.4 +/- 1.7 (21.7-27.6); percentage of excess weight lost, 87.6 +/- 11.8 (70.9-100) % with 100% remission of diabetes.
+
+ CONCLUSION: The results show the benefits of MGB/OAGB in mild obese diabetic patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11695-019-04071-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Navarrete+Aulestia&issn=0960-8923&title=Obesity+Surgery&atitle=One+Anastomosis+Gastric+Bypass%2FMinigastric+Bypass+in+Patients+with+BMI+%3C+35+kg%2Fm2+and+Type+2+Diabetes+Mellitus%3A+Preliminary+Report.&volume=29&issue=12&spage=3987&epage=3991&date=2019&doi=10.1007%2Fs11695-019-04071-4&pmid=31297740&sid=OVID:medline
+
+<1590>
+Unique Identifier
+ 31290748
+Title
+ Association of obesity with chronic kidney disease in elderly patients with nonalcoholic fatty liver disease.
+Source
+ Turkish Journal of Gastroenterology. 30(7):611-615, 2019 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Luo K; Bian J; Wang Q; Wang J; Chen F; Li H; Jin D
+Authors Full Name
+ Luo, Kexue; Bian, Jie; Wang, Qinxian; Wang, Jiesheng; Chen, Fuxing; Li, Hongchun; Jin, Dong.
+Institution
+ Luo, Kexue. Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
+ Bian, Jie. Sir Run Run Shaw Hospital, International Medical Center, Zhejiang University, Zhejiang, China.
+ Wang, Qinxian. Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
+ Wang, Jiesheng. Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
+ Chen, Fuxing. Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
+ Li, Hongchun. Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
+ Jin, Dong. Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
+MeSH Subject Headings
+ Age Factors
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Humans
+ Kidney Function Tests
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Obesity/co [Complications]
+ *Renal Insufficiency, Chronic/et [Etiology]
+ Risk Factors
+ Sex Factors
+ Uric Acid/bl [Blood]
+Abstract
+ BACKGROUND/AIMS: This study investigated an association between obesity and impaired renal functions in elderly patients with nonalcoholic fatty liver disease (NAFLD) and evaluated the risk factors for chronic kidney disease (CKD) in these patients.
+
+ MATERIALS AND METHODS: A cross-sectional study was performed involving 515 elderly patients (>= 60 years old) with NAFLD. Demographics, body mass index (BMI), medical history, and laboratory parameters were compared for groups stratified by obesity (>= 28 kg/m2) or CKD. An association between obesity and CKD was analyzed, and a multivariate logistic regression analysis was conducted for risk factors associated with CKD.
+
+ RESULTS: In the overall population, 28.7% were obese and 54.8% had CKD; there were more women (58.8%) than men. The prevalence of hypertension and diabetes was similar between the obese and nonobese groups and between the CKD and non-CKD groups. Obese patients had significantly higher levels of serum uric acid and estimated glomerular filtration rates when compared with the nonobese group. When compared with those without CKD, patients with CKD were significantly older in addition to having higher BMI and serum uric acid levels. The multivariate logistic regression analysis indicated that CKD was positively associated with age, BMI, and serum uric acid levels.
+
+ CONCLUSION: Elderly obese patients with NAFLD are at a higher risk of CKD. NAFLD patients with advanced age, greater BMI, or higher serum uric acid levels are more prone to developing CKD. The renal function of NAFLD patients should be closely monitored.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.5152%2ftjg.2019.18343
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Luo&issn=1300-4948&title=Turkish+Journal+of+Gastroenterology&atitle=Association+of+obesity+with+chronic+kidney+disease+in+elderly+patients+with+nonalcoholic+fatty+liver+disease.&volume=30&issue=7&spage=611&epage=615&date=2019&doi=10.5152%2Ftjg.2019.18343&pmid=31290748&sid=OVID:medline
+
+<1591>
+Unique Identifier
+ 31284750
+Title
+ Obesity paradox in heart failure: A matter of debate.
+Source
+ European Journal of Preventive Cardiology. 26(16):1748-1750, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Simonenko M
+Authors Full Name
+ Simonenko, Maria.
+Institution
+ Simonenko, Maria. Nacional'nyj Medicinskij Issledovatel'skij Centr Imeni V A Almazova, Saint Petersburg, Russian Federation.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Adipose Tissue
+ Biomarkers
+ *Heart Failure
+ Humans
+ *Obesity
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Comment.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1177%2f2047487319861473
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Simonenko&issn=2047-4873&title=European+Journal+of+Preventive+Cardiology&atitle=Obesity+paradox+in+heart+failure%3A+A+matter+of+debate.&volume=26&issue=16&spage=1748&epage=1750&date=2019&doi=10.1177%2F2047487319861473&pmid=31284750&sid=OVID:medline
+
+<1592>
+Unique Identifier
+ 31280277
+Title
+ The relationship between anthropometric status and rheumatoid arthritis. Exploring the role of nesfatin and asymmetric dimethylarginine.
+Original Title
+ The relationship between anthropometric status and rheumatoid arthritis. Exploring the role of nesfatin and asymmetric dimethylarginine.
+Source
+ Acta Reumatologica Portuguesa. 44(2):126-131, 2019 Apr-Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Naghashian F; Hosseinzadeh-Attar MJ; Akhlaghi M; Yekaninejad MS; Aryaeian N; Derakhshanian H
+Authors Full Name
+ Naghashian, Farnush; Hosseinzadeh-Attar, Mohammad Javad; Akhlaghi, Masoomeh; Yekaninejad, Mir Saeed; Aryaeian, Naheed; Derakhshanian, Hoda.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Arginine/aa [Analogs & Derivatives]
+ Arginine/bl [Blood]
+ *Arthritis, Rheumatoid/bl [Blood]
+ Arthritis, Rheumatoid/et [Etiology]
+ Biomarkers/bl [Blood]
+ Blood Sedimentation
+ Body Height
+ *Body Mass Index
+ *Body Size
+ Body Weight
+ C-Reactive Protein/an [Analysis]
+ Fasting/bl [Blood]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Male
+ Middle Aged
+ *Nucleobindins/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Risk Factors
+ Waist Circumference
+ Young Adult
+Abstract
+ OBJECTIVE: The aim of this study was to explore the anthropometric status of rheumatoid arthritis (RA) patients, as well as two controversial adipokines, namely nesfatin-1 and asymmetric dimethylarginine (ADMA), to reveal the possible relationships between them and RA.
+
+ METHODS: This study included RA patients who fulfilled the American college of rheumatology classification criteria. Anthropometric parameters including height, weight, and waist circumference (WC) were measured and body mass index (BMI) was calculated. Disease activity was assessed by 28 joints disease activity score (DAS28). Fasting plasma samples were collected and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), nesfatin-1 and asymmetric dimethylarginine (ADMA) were determined using commercial kits. Statistical analyses were done using the BMI SPSS Statistics.
+
+ RESULTS: A total of 77 patients including 63 females, with an average age of 48.45+/-11.26 and disease duration of 9.99+/-5.80 years participated the study, 62% of whom were overweight or obese. Disease activity was significantly higher in obese patients. In addition, BMI and WC were correlated with CRP and ESR, indicating higher level of inflammation in obese patients. DAS28 was also found to be correlated with CRP, ESR and ADMA (r=0.38, 0.61, 0.21 respectively). Higher protein intake was accompanied with higher CRP and ESR and higher carbohydrate intake was related to higher CRP and lower nesfatin-1.
+
+ CONCLUSIONS: Weight, BMI, and WC were correlated with the activity of RA and the concentrations of CRP and ESR went up in tandem with BMI. In addition, ADMA, but not nesfatin-1, was associated with BMI and disease activity in RA patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (NUCB2 protein, human). 0 (Nucleobindins). 63CV1GEK3Y (N,N-dimethylarginine). 9007-41-4 (C-Reactive Protein). 94ZLA3W45F (Arginine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&AN=31280277
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Naghashian&issn=0303-464X&title=Acta+Reumatologica+Portuguesa&atitle=The+relationship+between+anthropometric+status+and+rheumatoid+arthritis.+Exploring+the+role+of+nesfatin+and+asymmetric+dimethylarginine.&volume=44&issue=2&spage=126&epage=131&date=2019&doi=&pmid=31280277&sid=OVID:medline
+
+<1593>
+Unique Identifier
+ 31277301
+Title
+ Effects of Gelidium elegans on Weight and Fat Mass Reduction and Obesity Biomarkers in Overweight or Obese Adults: A Randomized Double-Blinded Study.
+Source
+ Nutrients. 11(7), 2019 Jul 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim CO; Kim YN; Lee DC
+Author NameID
+ Kim, Choon Ok; ORCID: https://orcid.org/0000-0002-2319-1108
+Authors Full Name
+ Kim, Choon Ok; Kim, Youn Nam; Lee, Duk-Chul.
+Institution
+ Kim, Choon Ok. Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University Health System, Seoul 03722, Korea.
+ Kim, Youn Nam. Clinical Trials Center, Severance Hospital, Yonsei University Health System, Seoul 03722, Korea.
+ Lee, Duk-Chul. Department of Family Medicine, Yonsei University, College of Medicine, Seoul 03722, Korea. faith@yuhs.ac.
+MeSH Subject Headings
+ *Adiposity/de [Drug Effects]
+ Adult
+ Anti-Obesity Agents/ae [Adverse Effects]
+ Anti-Obesity Agents/ip [Isolation & Purification]
+ *Anti-Obesity Agents/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ Dietary Supplements/ae [Adverse Effects]
+ *Dietary Supplements
+ Double-Blind Method
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ *Seaweed/ch [Chemistry]
+ Time Factors
+ Treatment Outcome
+ *Weight Loss/de [Drug Effects]
+ Young Adult
+Keyword Heading
+ Gelidium elegans
+ fat mass
+ obese
+ overweight
+ weight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The edible seaweed Gelidium elegans (GEE) is known to inhibit adipocyte differentiation. However, there has been no report on its effects in humans. In this study, we investigated whether GEE reduces body weight or fat mass in obese or overweight individuals. A total of 78 participants were randomly assigned to the test (GEE extract 1000 mg/day) and placebo groups at a 1:1 ratio, and treated for 12 weeks. At six or 12 weeks after randomization, they were evaluated for anthropometric parameters, biomarkers, and body composition. Changes in body weight and fat mass between the two groups was significantly different, as determined using ANCOVA adjusted for baseline, calorie intake, and physical activity. Body weight and fat mass were significantly decreased by GEE after 12 weeks but increased in the placebo group. Moreover, although not significant, triglyceride levels tended to decrease after GEE intake. There was no significant difference in other laboratory biomarkers between the two groups. Taken together, these results suggested that GEE significantly reduced body weight, especially fat mass, in overweight or obese individuals.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11071513
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=2072-6643&title=Nutrients&atitle=Effects+of+Gelidium+elegans+on+Weight+and+Fat+Mass+Reduction+and+Obesity+Biomarkers+in+Overweight+or+Obese+Adults%3A+A+Randomized+Double-Blinded+Study.&volume=11&issue=7&spage=&epage=&date=2019&doi=10.3390%2Fnu11071513&pmid=31277301&sid=OVID:medline
+
+<1594>
+Unique Identifier
+ 31275060
+Title
+ Biomarkers of Inflammation in Obesity-Psoriatic Patients. [Review]
+Source
+ Mediators of Inflammation. 2019:7353420, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rodriguez-Cerdeira C; Cordeiro-Rodriguez M; Carnero-Gregorio M; Lopez-Barcenas A; Martinez-Herrera E; Fabbrocini G; Sinani A; Arenas-Guzman R; Gonzalez-Cespon JL
+Author NameID
+ Rodriguez-Cerdeira, Carmen; ORCID: https://orcid.org/0000-0001-9939-0771
+ Arenas-Guzman, Roberto; ORCID: https://orcid.org/0000-0002-2992-9564
+Authors Full Name
+ Rodriguez-Cerdeira, Carmen; Cordeiro-Rodriguez, Monica; Carnero-Gregorio, Miguel; Lopez-Barcenas, Adriana; Martinez-Herrera, Erick; Fabbrocini, Gabriella; Sinani, Ardiana; Arenas-Guzman, Roberto; Gonzalez-Cespon, Jose Luis.
+Institution
+ Rodriguez-Cerdeira, Carmen. Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, Vigo, Spain.
+ Rodriguez-Cerdeira, Carmen. Dermatology Department, Hospital do Meixoeiro and University of Vigo, Vigo, Spain.
+ Rodriguez-Cerdeira, Carmen. European Women Dermatological and Venereological Society (EWDVS), Vigo, Spain.
+ Cordeiro-Rodriguez, Monica. Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, Vigo, Spain.
+ Carnero-Gregorio, Miguel. Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, Vigo, Spain.
+ Carnero-Gregorio, Miguel. Department of Molecular Diagnosis (Array & NGS Division), Institute of Cellular and Molecular Studies (ICM), Lugo, Spain.
+ Lopez-Barcenas, Adriana. European Women Dermatological and Venereological Society (EWDVS), Vigo, Spain.
+ Lopez-Barcenas, Adriana. Psychodermatology Task Force of the Ibero Latin American College of Dermatology, Argentina.
+ Lopez-Barcenas, Adriana. Mycoloy Service, Hospital Manuel Gea Gonzalez, Mexico City, Mexico.
+ Martinez-Herrera, Erick. Psychodermatology Task Force of the Ibero Latin American College of Dermatology, Argentina.
+ Martinez-Herrera, Erick. Research Unit, High Specialty Regional Hospital of Ixtapaluca, Ixtapaluca, Mexico.
+ Fabbrocini, Gabriella. European Women Dermatological and Venereological Society (EWDVS), Vigo, Spain.
+ Fabbrocini, Gabriella. Dermatology Service, University of Napoli Federico II, Naples, Italy.
+ Sinani, Ardiana. European Women Dermatological and Venereological Society (EWDVS), Vigo, Spain.
+ Sinani, Ardiana. Dermatology Service, Military Medical Unit, University Trauma Hospital, Tirana, Albania.
+ Arenas-Guzman, Roberto. European Women Dermatological and Venereological Society (EWDVS), Vigo, Spain.
+ Arenas-Guzman, Roberto. Psychodermatology Task Force of the Ibero Latin American College of Dermatology, Argentina.
+ Arenas-Guzman, Roberto. Mycoloy Service, Hospital Manuel Gea Gonzalez, Mexico City, Mexico.
+ Gonzalez-Cespon, Jose Luis. Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, Vigo, Spain.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ Humans
+ *Inflammation/bl [Blood]
+ Leptin/bl [Blood]
+ *Obesity/bl [Blood]
+ *Psoriasis/bl [Blood]
+ Resistin/bl [Blood]
+Abstract
+ Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psoriasis seems to be related to the severity of obesity. Patients with higher levels of obesity show poorer response to systemic treatments of psoriasis. Several studies have demonstrated that white adipose tissue is a crucial site of the formation of proinflammatory adipokines such as leptin, adiponectin, and resistin and classical cytokines such as interleukin- (IL-) 6 and tumour necrosis factor-alpha. In psoriasis, due to the proliferation of Th1, Th17, and Th22 cells, IL-22, among others, is produced in addition to the abovementioned cytokines. With respect to leptin and resistin, both of these adipokines are present in high levels in obese persons with psoriasis. Further, the plasma levels of leptin and resistin are related to the severity of psoriasis. These results strongly suggest that obesity, through proinflammatory pathways, is a predisposing factor to the development of psoriasis and that obesity aggravates existing psoriasis. Different inflammatory biomarkers link psoriasis and obesity. In this paper, the most important ones are described.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). 0 (Resistin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f7353420
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rodriguez-Cerdeira&issn=0962-9351&title=Mediators+of+Inflammation&atitle=Biomarkers+of+Inflammation+in+Obesity-Psoriatic+Patients.&volume=2019&issue=&spage=7353420&epage=&date=2019&doi=10.1155%2F2019%2F7353420&pmid=31275060&sid=OVID:medline
+
+<1595>
+Unique Identifier
+ 31271310
+Title
+ Inspiratory threshold loading reduces lipoperoxidation in obese and normal-weight subjects.
+Source
+ Physiology International. 106(2):158-167, 2019 Jun 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Callegaro CC; Hoffmeister AD; Porto FG; Chaves L; Horn RC; Tissiani AC; Bianchi P; Taylor JA
+Authors Full Name
+ Callegaro, C C; Hoffmeister, A D; Porto, F G; Chaves, L; Horn, R C; Tissiani, A C; Bianchi, Pda; Taylor, J A.
+Institution
+ Callegaro, C C. 1 Laboratory of Physiology and Rehabilitation, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.
+ Hoffmeister, A D. 2 Postgraduate Program in Integral Attention to Health (PPGAIS-UNIJUI/UNICRUZ), Ijui, Brazil.
+ Hoffmeister, A D. 3 University of Cruz Alta, Cruz Alta, Brazil.
+ Porto, F G. 2 Postgraduate Program in Integral Attention to Health (PPGAIS-UNIJUI/UNICRUZ), Ijui, Brazil.
+ Porto, F G. 3 University of Cruz Alta, Cruz Alta, Brazil.
+ Chaves, L. 3 University of Cruz Alta, Cruz Alta, Brazil.
+ Horn, R C. 2 Postgraduate Program in Integral Attention to Health (PPGAIS-UNIJUI/UNICRUZ), Ijui, Brazil.
+ Horn, R C. 3 University of Cruz Alta, Cruz Alta, Brazil.
+ Tissiani, A C. 3 University of Cruz Alta, Cruz Alta, Brazil.
+ Bianchi, Pda. 3 University of Cruz Alta, Cruz Alta, Brazil.
+ Taylor, J A. 4 Harvard Medical School, Boston, MA, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Exercise/ph [Physiology]
+ Female
+ Glutathione/me [Metabolism]
+ Humans
+ *Inhalation/ph [Physiology]
+ *Lipid Peroxidation/ph [Physiology]
+ Male
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Oxidative Stress/ph [Physiology]
+ Protein Carbonylation/ph [Physiology]
+ Thiobarbituric Acid Reactive Substances/me [Metabolism]
+ Weights and Measures
+Keyword Heading
+ inspiratory exercise
+ inspiratory muscle strength
+ obesity
+ oxidative stress
+ thiobarbituric acid reactive substances
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is related to increased oxidative stress. Although low-intensity physical exercise reduces oxidative stress, obese subjects may show exercise intolerance. For these subjects, inspiratory threshold loading could be an alternative tool to reduce oxidative stress. We investigated the effects of inspiratory threshold loading on biomarkers of oxidative stress in obese and normal-weight subjects. Twenty obese (31.4 +/- 6 years old, 10 men and 10 women, 37.5 +/- 4.7 kg/m2) and 20 normal-weight (29.4 +/- 8 years old, 10 men and 10 women, 23.2 +/- 1.5 kg/m2) subjects matched for age and gender participated in the study. Maximal inspiratory pressure (MIP) was assessed by a pressure transducer. Blood sampling was performed before and after loading and control protocols to assess thiobarbituric acid reactive substances (TBARS), protein carbonylation, and reduced glutathione. Inspiratory threshold loading was performed at 60% MIP and maintained until task failure. The 30-min control protocol was performed at 0 cmH2O. Our results demonstrated that inspiratory threshold loading reduced TBARS across time in obese (6.21 +/- 2.03 to 4.91 +/- 2.14 nmol MDA/ml) and normal-weight subjects (5.60 +/- 3.58 to 4.69 +/- 2.80 nmol MDA/ml; p = 0.007), but no change was observed in protein carbonyls and glutathione in both groups. The control protocol showed no significant changes in TBARS and protein carbonyls. However, reduced glutathione was increased across time in both groups (obese: from 0.50 +/- 0.37 to 0.56 +/- 0.35 mumol GSH/ml; normal-weight: from 0.61 +/- 0.11 to 0.81 +/- 0.23 mumol GSH/ml; p = 0.002). These findings suggest that inspiratory threshold loading could be potentially used as an alternative tool to reduce oxidative stress in both normal-weight and obese individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Thiobarbituric Acid Reactive Substances). GAN16C9B8O (Glutathione).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1556%2f2060.106.2019.12
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Callegaro&issn=2498-602X&title=Physiology+International&atitle=Inspiratory+threshold+loading+reduces+lipoperoxidation+in+obese+and+normal-weight+subjects.&volume=106&issue=2&spage=158&epage=167&date=2019&doi=10.1556%2F2060.106.2019.12&pmid=31271310&sid=OVID:medline
+
+<1596>
+Unique Identifier
+ 31269728
+Title
+ Use of an Extract of Annona muricata Linn to Prevent High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice.
+Source
+ Nutrients. 11(7), 2019 Jul 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sasso S; Sampaio E Souza PC; Santana LF; Cardoso CAL; Alves FM; Portugal LC; de Faria BB; da Silva AF; Motta-Castro ARC; Soares LS; Bandeira LM; Guimaraes RCA; Freitas KC
+Author NameID
+ Sasso, Sandramara; ORCID: https://orcid.org/0000-0002-3010-9715
+Authors Full Name
+ Sasso, Sandramara; Sampaio E Souza, Priscilla Cristovam; Santana, Lidiani Figueiredo; Cardoso, Claudia Andrea Lima; Alves, Flavio Macedo; Portugal, Luciane Candeloro; de Faria, Bernardo Bacelar; da Silva, Anderson Fernandes; Motta-Castro, Ana Rita Coimbra; Soares, Luana Silva; Bandeira, Larissa Melo; Guimaraes, Rita de Cassia Avellaneda; Freitas, Karine de Cassia.
+Institution
+ Sasso, Sandramara. Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Sampaio E Souza, Priscilla Cristovam. Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Santana, Lidiani Figueiredo. Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Cardoso, Claudia Andrea Lima. Course of Chemistry, State University of Mato Grosso do Sul, Dourados, 79070-900 Mato Grosso do Sul, Brazil.
+ Alves, Flavio Macedo. Institute of Biosciences, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Portugal, Luciane Candeloro. Institute of Biosciences, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ de Faria, Bernardo Bacelar. Medicina Diagnostica Laboratory-Scapulatempo, Campo Grande, 79002-170 Mato Grosso do Sul, Brazil.
+ da Silva, Anderson Fernandes. Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Motta-Castro, Ana Rita Coimbra. Laboratory of Clinical Immunology, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Motta-Castro, Ana Rita Coimbra. Oswaldo Cruz Foundation, Campo Grande, 79074-460 Mato Grosso do Sul, Brazil.
+ Soares, Luana Silva. Laboratory of Clinical Immunology, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Bandeira, Larissa Melo. Laboratory of Clinical Immunology, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Guimaraes, Rita de Cassia Avellaneda. Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
+ Freitas, Karine de Cassia. Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil. kcfreitas@gmail.com.
+MeSH Subject Headings
+ Adiposity/de [Drug Effects]
+ Animals
+ Annona/ch [Chemistry]
+ *Annona
+ Anti-Obesity Agents/ip [Isolation & Purification]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Anti-Obesity Agents/to [Toxicity]
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Diet, High-Fat
+ Disease Models, Animal
+ Female
+ Glucose Metabolism Disorders/bl [Blood]
+ *Glucose Metabolism Disorders/dt [Drug Therapy]
+ Glucose Metabolism Disorders/pp [Physiopathology]
+ Inflammation Mediators/bl [Blood]
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ Plant Extracts/to [Toxicity]
+ Plant Leaves
+ Rats, Wistar
+ Weight Gain/de [Drug Effects]
+Keyword Heading
+ graviola
+ obesity
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Annona muricata Linn, commonly known as graviola, is one of the most popular plants used in Brazil for weight loss. The aim of this study is to evaluate the therapeutic effects of three different doses (50 mg/kg, 100 mg/kg, and 150 mg/kg) of aqueous graviola leaf extract (AGE) supplemented by oral gavage, on obese C57BL/6 mice. Food intake, body weight, an oral glucose tolerance test (OGTT), an insulin sensitivity test, quantification of adipose tissue cytokines, weight of fat pads, and serum biochemical and histological analyses of the liver, pancreas, and epididymal adipose tissue were measured. AGE had an anti-inflammatory effect by increasing IL-10 at doses of 50 and 100 mg/kg. Regarding the cholesterol profile, there was a significant decrease in LDL-cholesterol levels in the AGE 150 group, and VLDL-cholesterol and triglycerides in the AGE 100 and 150 groups. There was an increase in HDL cholesterol in the AGE 150 group. The extract was able to reduce the adipocyte area of the epididymal adipose tissue in the AGE 100 and 150 groups. According to the histological analysis of the liver and pancreas, no significant difference was found among the groups. There were no significant effects of AGE on OGTT and serum fasting glucose concentration. However, the extract was effective in improving glucose tolerance in the AGE 150 group.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Blood Glucose). 0 (Inflammation Mediators). 0 (Lipids). 0 (Plant Extracts).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11071509
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sasso&issn=2072-6643&title=Nutrients&atitle=Use+of+an+Extract+of+Annona+muricata+Linn+to+Prevent+High-Fat+Diet+Induced+Metabolic+Disorders+in+C57BL%2F6+Mice.&volume=11&issue=7&spage=&epage=&date=2019&doi=10.3390%2Fnu11071509&pmid=31269728&sid=OVID:medline
+
+<1597>
+Unique Identifier
+ 31266190
+Title
+ Role of Hypovitaminosis D in the Pathogenesis of Obesity-Induced Insulin Resistance. [Review]
+Source
+ Nutrients. 11(7), 2019 Jul 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Greco EA; Lenzi A; Migliaccio S
+Authors Full Name
+ Greco, Emanuela A; Lenzi, Andrea; Migliaccio, Silvia.
+Institution
+ Greco, Emanuela A. Department of Experimental Medicine, Section of Physiopathology, Endocrinology and Food Science, University of Rome Sapienza, 00161 Rome, Italy.
+ Lenzi, Andrea. Department of Experimental Medicine, Section of Physiopathology, Endocrinology and Food Science, University of Rome Sapienza, 00161 Rome, Italy.
+ Migliaccio, Silvia. Department of Movement, Human and Health Sciences, Section of Health Science, University of Rome Foro Italico, 00135 Rome, Italy. silvia.migliaccio@uniroma4.it.
+MeSH Subject Headings
+ Adiposity
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ *Energy Metabolism
+ Humans
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ Risk Factors
+ *Vitamin D/bl [Blood]
+ *Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/ep [Epidemiology]
+ Vitamin D Deficiency/pp [Physiopathology]
+Keyword Heading
+ hypovitaminosis D
+ inflammation
+ insulin resistance
+ obesity
+ type 2 diabetes
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and type 2 diabetes have both rapidly increased during the last decades and are continuing to increase at an alarming rate worldwide. Obesity and impaired glucose homeostasis are closely related, and during the last decades of investigation about vitamin D, several clinical and epidemiological studies documented an inverse correlation between circulating vitamin D levels, central adiposity and the development of insulin resistance and diabetes. The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11071506
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Greco&issn=2072-6643&title=Nutrients&atitle=Role+of+Hypovitaminosis+D+in+the+Pathogenesis+of+Obesity-Induced+Insulin+Resistance.&volume=11&issue=7&spage=&epage=&date=2019&doi=10.3390%2Fnu11071506&pmid=31266190&sid=OVID:medline
+
+<1598>
+Unique Identifier
+ 31265774
+Title
+ [Immunological markers of alimentary-induced hyperlipidemia in Wistar rats]. [Russian]
+Source
+ Voprosy Pitaniia. 88(3):44-52, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Riger NA; Shipelin VA; Apryatin SA; Gmoshinski IV
+Author NameID
+ Riger, N A; ORCID: https://orcid.org/0000-0001-7149-2485
+ Shipelin, V A; ORCID: https://orcid.org/0000-0002-0015-87354
+ Apryatin, S A; ORCID: https://orcid.org/0000-0002-6543-7495
+ Gmoshinski, I V; ORCID: https://orcid.org/0000-0002-3671-6508
+Authors Full Name
+ Riger, N A; Shipelin, V A; Apryatin, S A; Gmoshinski, I V.
+Institution
+ Riger, N A. Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.
+ Shipelin, V A. Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.
+ Apryatin, S A. Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.
+ Gmoshinski, I V. Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ *Cytokines/bl [Blood]
+ Female
+ *Food, Formulated/ae [Adverse Effects]
+ Hyperlipidemias/bl [Blood]
+ Hyperlipidemias/ci [Chemically Induced]
+ *Hyperlipidemias
+ Obesity/bl [Blood]
+ Obesity/ci [Chemically Induced]
+ *Obesity
+ Rats
+ Rats, Wistar
+Keyword Heading
+ cholecterol
+ cytokines
+ ghrelin
+ hyperlipidemia
+ leptin
+ rats
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Changes in plasma levels of the main groups of cytokines and adipokines may correlate with the severity of metabolic disorders in hyperlipidemia and obesity. The aim of the study was to assess the significance of ghrelin, leptin, their ratio (L/Gh), and the cytokine profile as biomarkers at dietary-induced hyperlipidemia. Material and methods. We used 48 female Wistar rats with an initial body weight of 123+/-1 g, which were divided into 6 groups. Group 1 (control) received a balanced semi-synthetic diet according to AIN93; group 2 - diet with excess fat (30% by weight); group 3 - a diet with the addition of 20% fructose solution instead of drinking water, group 4 - a diet with excess fat and fructose, group 5 - a diet with added cholesterol (0.5%), group 6 - a diet with cholesterol and fructose. On the 64th day of the experiment, the mass of internal organs was determined; the levels of cytokines and adipokines in blood plasma were measured by multiplex immunoassay. Results and discussion. A decrease in the level of leptin was found in group 5 compared with the control and with groups 2, 4 and 6 groups (p<0.05). The lowest level of ghrelin was found in group 2 (p<0.05) against the background of high concentrations of leptin. Significant correlations were found between L/Gh and the total mass of animals (r=0.321; p=0.034), the relative mass of adipose tissue (r=0.439; p=0.003) and with the relative mass of the spleen (r=-0.460; p=0.003). In group 2, at the maximum L/Gh ratio, a significantly higher weight of adipose tissue was found, whereas in groups 3 and 5, at the lowest L/Gh ratio, the relative amount of total fat was the lowest. L/Gh ratio correlated with the level of monocyte chemotactic protein-1 (MCP-1), RANTES, IL-18 and macrophage colony-stimulating factor (M-CSF). The concentrations of IL-17, IL-18, IL-4, IL-5, MIP-3a, IFN-gamma, M-CSF and RANTES in the experimental groups were reduced compared with the control, with the most pronounced effect in group 5 together with the lowest L/Gh ratio. Conclusion. The presence of a significant correlation between L/Gh ratio and changes in the weight of rats' body, spleen, adipose tissue, as well as levels of cytokines involved in inflammation regulation, confirms the importance of L/Gh ratio as a biomarker in an in vivo model of dyslipidemia. Copyright© GEOTAR-Media Publishing Group.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.24411%2f0042-8833-2019-10028
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Riger&issn=0042-8833&title=Voprosy+Pitaniia&atitle=%5BImmunological+markers+of+alimentary-induced+hyperlipidemia+in+Wistar+rats%5D.&volume=88&issue=3&spage=44&epage=52&date=2019&doi=10.24411%2F0042-8833-2019-10028&pmid=31265774&sid=OVID:medline
+
+<1599>
+Unique Identifier
+ 31261928
+Title
+ Mixed Nut Consumption May Improve Cardiovascular Disease Risk Factors in Overweight and Obese Adults.
+Source
+ Nutrients. 11(7), 2019 Jun 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abbaspour N; Roberts T; Hooshmand S; Kern M; Hong MY
+Authors Full Name
+ Abbaspour, Nazanin; Roberts, Traci; Hooshmand, Shirin; Kern, Mark; Hong, Mee Young.
+Institution
+ Abbaspour, Nazanin. School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, USA.
+ Roberts, Traci. School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, USA.
+ Hooshmand, Shirin. School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, USA.
+ Kern, Mark. School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, USA.
+ Hong, Mee Young. School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, USA. mhong2@sdsu.edu.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Female
+ Humans
+ Insulin/bl [Blood]
+ L-Lactate Dehydrogenase/bl [Blood]
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Nuts
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Risk Factors
+ *Snacks
+ Time Factors
+ Treatment Outcome
+ *Weight Loss
+ Young Adult
+Keyword Heading
+ cholesterol
+ glucose
+ insulin
+ mixed nuts
+ randomized controlled trial
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Emerging research indicates that nuts are a source of health-promoting compounds demonstrating cardioprotective benefits. However, most studies have assessed the effect of single nuts rather than a nut mixture. The objective of this study was, therefore, to examine the effect of mixed-nut consumption on cardiovascular disease (CVD) risk factors in overweight and obese adults. In a randomized, parallel-arm, controlled trial, 48 participants consumed isocaloric (250 kcal) amounts of pretzels or mixed-nuts. Body weight (BW) (p = 0.024), BMI (p = 0.043), and insulin levels (p = 0.032) were significantly lower in the nut group compared to the pretzel group. Mixed-nut consumption also significantly reduced glucose (p = 0.04) and insulin (p = 0.032) levels after 4 and 8 weeks compared to baseline, respectively. Lactate dehydrogenase of the nut group was significantly lower than the pretzel group (p = 0.002). No significant differences were detected between groups for triglycerides, LDL-C, and HDL-C. However, pretzel consumption increased triglycerides (p = 0.048) from 4 weeks to 8 weeks. Moreover, LDL-C increased (p = 0.038) while HDL-C transiently decreased (p = 0.044) from baseline to 4 weeks. No significant lipid changes were detected within the nut group. Our results suggest that supplementing the diet with mixed-nuts could improve CVD risk factors by improving BW and glucose regulation in comparison to a common carbohydrate-rich snack without promoting the negative effects on lipids detected with pretzels.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Lipids). EC 1-1-1-27 (L-Lactate Dehydrogenase).
+Publication Type
+ Comparative Study. Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11071488
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abbaspour&issn=2072-6643&title=Nutrients&atitle=Mixed+Nut+Consumption+May+Improve+Cardiovascular+Disease+Risk+Factors+in+Overweight+and+Obese+Adults.&volume=11&issue=7&spage=&epage=&date=2019&doi=10.3390%2Fnu11071488&pmid=31261928&sid=OVID:medline
+
+<1600>
+Unique Identifier
+ 31257412
+Title
+ Sex and Body Mass Index Modify the Association Between Leptin and Sodium Excretion: A Cross-sectional Study in an African Population.
+Source
+ American Journal of Hypertension. 32(11):1101-1108, 2019 10 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schwotzer N; Burnier M; Maillard M; Bovet P; Paccaud F; Bochud M; Wuerzner G
+Authors Full Name
+ Schwotzer, Nora; Burnier, Michel; Maillard, Marc; Bovet, Pascal; Paccaud, Fred; Bochud, Murielle; Wuerzner, Gregoire.
+Institution
+ Schwotzer, Nora. Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
+ Burnier, Michel. Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
+ Maillard, Marc. Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
+ Bovet, Pascal. University Institute of Social and Preventive Medicine, Lausanne, Switzerland.
+ Paccaud, Fred. University Institute of Social and Preventive Medicine, Lausanne, Switzerland.
+ Bochud, Murielle. University Institute of Social and Preventive Medicine, Lausanne, Switzerland.
+ Wuerzner, Gregoire. Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ *Black People
+ *Body Mass Index
+ Circadian Rhythm
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Kidney Tubules, Proximal/pp [Physiopathology]
+ *Leptin/bl [Blood]
+ Male
+ Middle Aged
+ *Natriuresis
+ Obesity/bl [Blood]
+ Obesity/eh [Ethnology]
+ *Obesity/pp [Physiopathology]
+ Obesity/ur [Urine]
+ *Renal Reabsorption
+ Sex Factors
+ Seychelles/ep [Epidemiology]
+ *Sodium/ur [Urine]
+ Time Factors
+Keyword Heading
+ Africa
+ BMI
+ adiponectin
+ blood pressure
+ hypertension
+ leptin
+ lithium clearance
+ sex
+ sodium excretion
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Renal sodium handling could be a potential mediator linking adipokines to hypertension. The aim of the study was to assess the relationship of leptin with urinary sodium excretion and proximal sodium reabsorption in humans.
+
+ METHODS: This cross-sectional study was conducted on participants of hypertensive families from the Seychelles Island. A split urine (daytime and nighttime) collection and plasma leptin were measured. Endogenous lithium clearance was used to assess proximal sodium reabsorption. Mixed multiple linear regression tests adjusted for confounding factors were used.
+
+ RESULTS: Three hundred and sixty-five participants (57% women) were included in this analysis. Leptin and adiponectin were higher in women (P < 0.001). Leptin was associated positively with daytime (coefficient [c]: 0.16, standard deviation (SD): 0.03, P < 0.001), nighttime urinary sodium excretion (c: 0.17, SD: 0.04), P < 0.01), daytime lithium clearance (c: 0.40, SD: 0.08, P < 0.001), and nighttime lithium clearance (c: 0.39, SD: 0.10, P < 0.001) after adjusting for sex. The association was lost or mitigated only when BMI was introduced in the model. When BMI was categorized in normal vs. overweight participant, leptin was associated with daytime and nighttime sodium excretion rates (c: 0.14, SD: 0.05, P = 0.011 and c: 0.22, SD: 0.07, P = 0.002, respectively) only in overweight participants.
+
+ CONCLUSION: Leptin is associated positively with daytime and nighttime sodium excretion and lithium clearance suggesting a natriuretic rather than a sodium retaining effect of leptin. Sex and body mass index (BMI) are major confounders in this association. These results highlight the importance of sex and obesity in our understanding of the relationships between leptin, blood pressure, and renal sodium handling. Copyright © American Journal of Hypertension, Ltd 2019. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (LEP protein, human). 0 (Leptin). 9NEZ333N27 (Sodium).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fajh%2fhpz106
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schwotzer&issn=0895-7061&title=American+Journal+of+Hypertension&atitle=Sex+and+Body+Mass+Index+Modify+the+Association+Between+Leptin+and+Sodium+Excretion%3A+A+Cross-sectional+Study+in+an+African+Population.&volume=32&issue=11&spage=1101&epage=1108&date=2019&doi=10.1093%2Fajh%2Fhpz106&pmid=31257412&sid=OVID:medline
+
+<1601>
+Unique Identifier
+ 31252598
+Title
+ Six Weeks of Calorie Restriction Improves Body Composition and Lipid Profile in Obese and Overweight Former Athletes.
+Source
+ Nutrients. 11(7), 2019 Jun 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Holowko J; Michalczyk MM; Zajac A; Czerwinska-Rogowska M; Ryterska K; Banaszczak M; Jakubczyk K; Stachowska E
+Author NameID
+ Holowko, Joanna; ORCID: https://orcid.org/0000-0002-3067-0692
+ Michalczyk, Malgorzata Magdalena; ORCID: https://orcid.org/0000-0003-1590-3002
+ Zajac, Adam; ORCID: https://orcid.org/0000-0002-4374-4822
+ Ryterska, Karina; ORCID: https://orcid.org/0000-0003-2791-3312
+ Jakubczyk, Karolina; ORCID: https://orcid.org/0000-0002-5853-9709
+Authors Full Name
+ Holowko, Joanna; Michalczyk, Malgorzata Magdalena; Zajac, Adam; Czerwinska-Rogowska, Maja; Ryterska, Karina; Banaszczak, Marcin; Jakubczyk, Karolina; Stachowska, Ewa.
+Institution
+ Holowko, Joanna. Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 71-460 Szczecin, Poland.
+ Michalczyk, Malgorzata Magdalena. Department of Sport Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, 40-065 Katowice, Poland. m.michalczyk@awf.katowice.pl.
+ Zajac, Adam. Department of Sport Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, 40-065 Katowice, Poland.
+ Czerwinska-Rogowska, Maja. Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 71-460 Szczecin, Poland.
+ Ryterska, Karina. Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 71-460 Szczecin, Poland.
+ Banaszczak, Marcin. Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 71-460 Szczecin, Poland.
+ Jakubczyk, Karolina. Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 71-460 Szczecin, Poland.
+ Stachowska, Ewa. Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 71-460 Szczecin, Poland.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adiposity
+ Adult
+ *Athletes
+ Biomarkers/bl [Blood]
+ *Body Composition
+ *Caloric Restriction
+ Humans
+ Leptin/bl [Blood]
+ *Lipids/bl [Blood]
+ Male
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Time Factors
+ Treatment Outcome
+ *Weight Loss
+Keyword Heading
+ IGF-1
+ adiponectin
+ body mass reduction
+ calorie restriction diet
+ insulin
+ leptin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The aim of the study was to compare the impact of 6 weeks of reducing daily caloric intake by 20% of total daily energy expenditure (TDEE)-CRI vs. reducing daily caloric intake by 30% of TDEE-CRII on body mass reduction and insulin metabolism in former athletes.
+
+ METHODS: 94 males aged 35.7 +/- 5.3 years, height 180.5 +/- 4.1 cm, and body mass 96.82 +/- 6.2 kg were randomly assigned to the CRI (n = 49) or CRII (n = 45) group. Thirty-one participants (18 subjects from CRI and 13 from CRII) resigned from the study. The effects of both diets on the body composition variables (body mass-BM; body fat-BF; fat free mass-FFM; muscle mass-MM; total body water-TBW), lipid profile (total lipids-TL; total cholesterol-TCh; HDL cholesterol-HDL; LDL cholesterol-LDL; triglycerides-TG), and glucose control variables (glucose-GL, insulin-I, HOMA-IR, insulin-like growth factor-1-IGF-1, leptin and adiponectin) were measured.
+
+ RESULTS: After adhering to the CR I diet, significant differences were observed in FFM, MM and TG. After adhering to the CR II diet, significant differences were registered in tCh, TL and LDL. Both diets had a significant influence on leptin and adiponectin concentrations. Significant differences in FFM, MM, and tCh were observed between the CR I and CR II groups. At the end of the dietary intervention, significant differences in BF, FFM, MM and TBW were observed between the CR I and CR II groups.
+
+ CONCLUSION: The 6 weeks of CR II diet appeared to be more effective in reducing BF and lipid profile and proved to be especially suitable for subjects with high body fat content and an elevated level of lipoproteins and cholesterol. Both reductive diets were effective in improving the levels of leptin and adiponectin in obese former athletes.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (LEP protein, human). 0 (Leptin). 0 (Lipids).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11071461
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Holowko&issn=2072-6643&title=Nutrients&atitle=Six+Weeks+of+Calorie+Restriction+Improves+Body+Composition+and+Lipid+Profile+in+Obese+and+Overweight+Former+Athletes.&volume=11&issue=7&spage=&epage=&date=2019&doi=10.3390%2Fnu11071461&pmid=31252598&sid=OVID:medline
+
+<1602>
+Unique Identifier
+ 31252555
+Title
+ Vitamin D and Obesity: Two Interacting Players in the Field of Infertility. [Review]
+Source
+ Nutrients. 11(7), 2019 Jun 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bosdou JK; Konstantinidou E; Anagnostis P; Kolibianakis EM; Goulis DG
+Authors Full Name
+ Bosdou, Julia K; Konstantinidou, Eirini; Anagnostis, Panagiotis; Kolibianakis, Efstratios M; Goulis, Dimitrios G.
+Institution
+ Bosdou, Julia K. Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
+ Konstantinidou, Eirini. Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
+ Anagnostis, Panagiotis. Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. pan.anagnostis@gmail.com.
+ Kolibianakis, Efstratios M. Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
+ Goulis, Dimitrios G. Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Dietary Supplements
+ Female
+ *Fertility
+ Humans
+ Infertility, Female/bl [Blood]
+ *Infertility, Female/ep [Epidemiology]
+ Infertility, Female/pp [Physiopathology]
+ Infertility, Female/th [Therapy]
+ Infertility, Male/bl [Blood]
+ *Infertility, Male/ep [Epidemiology]
+ Infertility, Male/pp [Physiopathology]
+ Infertility, Male/th [Therapy]
+ Male
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ Pregnancy
+ Prognosis
+ Reproductive Techniques, Assisted
+ Risk Assessment
+ Risk Factors
+ *Vitamin D/bl [Blood]
+ Vitamin D/tu [Therapeutic Use]
+ Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/dt [Drug Therapy]
+ *Vitamin D Deficiency/ep [Epidemiology]
+ Vitamin D Deficiency/pp [Physiopathology]
+Keyword Heading
+ assisted reproductive technologies
+ infertility
+ obesity
+ vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity plays an important role in human fertility in both genders. The same is true for vitamin D, for which accumulating evidence from observational human studies suggests a key role for both male and female fertility. In the latter case, however, robust data from relevant interventional studies are currently lacking. It is also not clear whether obesity and vitamin D deficiency, besides their independent effect on human infertility, act in synergy. Several pathogenetic mechanisms may be proposed as a linkage between vitamin D deficiency and obesity, with respect to infertility. In any case, the independent contribution of vitamin D deficiency in obese infertile states needs to be proven in interventional studies focusing on either vitamin D supplementation in obese or weight loss strategies in vitamin D-deficient infertile patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11071455
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bosdou&issn=2072-6643&title=Nutrients&atitle=Vitamin+D+and+Obesity%3A+Two+Interacting+Players+in+the+Field+of+Infertility.&volume=11&issue=7&spage=&epage=&date=2019&doi=10.3390%2Fnu11071455&pmid=31252555&sid=OVID:medline
+
+<1603>
+Unique Identifier
+ 31249229
+Title
+ Creatinine and cystatin C-based evaluation of renal function among obese subjects in Benin City, Nigeria.
+Source
+ Saudi Journal of Kidney Diseases & Transplantation. 30(3):648-654, 2019 May-Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alaje AK; Adedeji TA; Adedoyin AR; Idogun SE
+Authors Full Name
+ Alaje, Abiodun K; Adedeji, Tewogbade A; Adedoyin, Adebukola R; Idogun, Sylvester E.
+Institution
+ Alaje, Abiodun K. Department of Chemical Pathology, Obafemi Awolowo University, Ile-Ife, Nigeria.
+ Adedeji, Tewogbade A. Department of Chemical Pathology, Obafemi Awolowo University, Ile-Ife, Nigeria.
+ Adedoyin, Adebukola R. Department of Medical Rehabilitation, Obafemi Awolowo University, Ile-Ife, Nigeria.
+ Idogun, Sylvester E. Department of Chemical Pathology, University of Benin Teaching Hospital, Benin City, Nigeria.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Creatinine/bl [Blood]
+ Cross-Sectional Studies
+ *Cystatin C/bl [Blood]
+ Female
+ *Glomerular Filtration Rate
+ Humans
+ *Kidney/pp [Physiopathology]
+ Kidney Diseases/bl [Blood]
+ *Kidney Diseases/di [Diagnosis]
+ Kidney Diseases/ep [Epidemiology]
+ Kidney Diseases/pp [Physiopathology]
+ Male
+ Middle Aged
+ *Models, Biological
+ Nigeria/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Predictive Value of Tests
+ Prevalence
+ Reproducibility of Results
+ Risk Factors
+ Young Adult
+Abstract
+ Obesity is a recognized worldwide epidemic with increasing prevalence in developing nations. Studies have shown that obesity is an independent risk factor for the development of chronic kidney disease (CKD) besides its link with diabetes mellitus and hypertension. We evaluated the renal status of obese patients using both the established [creatinine (Cr)] and new (cystatin C) markers of renal function. This was a cross-sectional study. Fifty-nine consenting adults attending the clinic for routine medical checks were recruited for this study. They were divided into obese and non-obese based on their body mass index. Serum from specimens collected were assayed for Cr and cystatin C. CKD equations were used to estimate glomerular filtration rate based on Cr (eGFR-Cr), cystatin C (GFR-Cystatin), and Cr/cystatin C (GFRCr/cystatin) while modification of diet in renal disease equation was also used to eGFR-Cr. The eGFR results generated were compared in assessing renal function. The obese participants and the controls were age-matched (50.6 +/- 9.7 vs. 50.7 +/- 7.8 years, P = 0.2). The obese participants had a significantly higher serum cystatin C (1.3 +/- 0.7 vs. 0.9 +/- 0.4 mg/L, P < 0.001) and significantly lower eGFR-cystatin C (75.4 +/- 38.9 mL/min/1.73 m2 vs. 90.9 +/- 25.1 mL/min/1.73 m2, P < 0.001) than the controls, respectively. There was a significant difference between the eGFR-Cr and eGFR-cystatin C in the obese participants (97.4 +/- 21.4 vs. 75.4 +/- 38.9 mL/min/1.73 m2), P = 0.019). The results showed that mild renal impairment exists among obese participants. Routine assessment is recommended to pre-empt deterioration in renal function. Cystatin C appears to be a better marker of renal function in obesity than serum Cr.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CST3 protein, human). 0 (Cystatin C). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.4103%2f1319-2442.261339
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alaje&issn=1319-2442&title=Saudi+Journal+of+Kidney+Diseases+%26+Transplantation&atitle=Creatinine+and+cystatin+C-based+evaluation+of+renal+function+among+obese+subjects+in+Benin+City%2C+Nigeria.&volume=30&issue=3&spage=648&epage=654&date=2019&doi=10.4103%2F1319-2442.261339&pmid=31249229&sid=OVID:medline
+
+<1604>
+Unique Identifier
+ 31247902
+Title
+ The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. [Review]
+Source
+ International Journal of Molecular Sciences. 20(13), 2019 Jun 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chan PC; Liao MT; Hsieh PS
+Author NameID
+ Hsieh, Po-Shiuan; ORCID: https://orcid.org/0000-0002-3402-9851
+Authors Full Name
+ Chan, Pei-Chi; Liao, Min-Tser; Hsieh, Po-Shiuan.
+Institution
+ Chan, Pei-Chi. Institute of Physiology, National Defense Medical Center, Taipei 114, Taiwan.
+ Liao, Min-Tser. Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan.
+ Liao, Min-Tser. Department of Pediatrics, Tri-Service General Hospital, Taipei 114, Taiwan.
+ Hsieh, Po-Shiuan. Institute of Physiology, National Defense Medical Center, Taipei 114, Taiwan. pshsieh@hotmail.com.
+ Hsieh, Po-Shiuan. Department of Medical Research, Tri-Service General Hospital, Taipei 114, Taiwan. pshsieh@hotmail.com.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Animals
+ Biomarkers
+ *Cyclooxygenase 2/me [Metabolism]
+ Energy Metabolism
+ Humans
+ *Insulin Resistance
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Models, Biological
+ Molecular Targeted Therapy
+ Obesity/co [Complications]
+ Obesity/dt [Drug Therapy]
+ *Obesity/me [Metabolism]
+ Prostaglandins/me [Metabolism]
+ *Signal Transduction
+Keyword Heading
+ cyclooxygenase II
+ energy metabolism
+ metabolic syndrome
+ obesity
+ prostaglandins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and insulin resistance are two major risk factors for the development of metabolic syndrome, type 2 diabetes and associated cardiovascular diseases (CVDs). Cyclooxygenase (COX), a rate-limiting enzyme responsible for the biosynthesis of prostaglandins (PGs), exists in two isoforms: COX-1, the constitutive form, and COX-2, mainly the inducible form. COX-2 is the key enzyme in eicosanoid metabolism that converts eicosanoids into a number of PGs, including PGD2, PGE2, PGF2alpha, and prostacyclin (PGI2), all of which exert diverse hormone-like effects via autocrine or paracrine mechanisms. The COX-2 gene and immunoreactive proteins have been documented to be highly expressed and elevated in adipose tissue (AT) under morbid obesity conditions. On the other hand, the environmental stress-induced expression and constitutive over-expression of COX-2 have been reported to play distinctive roles under different pathological and physiological conditions; i.e., over-expression of the COX-2 gene in white AT (WAT) has been shown to induce de novo brown AT (BAT) recruitment in WAT and then facilitate systemic energy expenditure to protect mice against high-fat diet-induced obesity. Hepatic COX-2 expression was found to protect against diet-induced steatosis, obesity, and insulin resistance. However, COX-2 activation in the epidydimal AT is strongly correlated with the development of AT inflammation, insulin resistance, and fatty liver in high-fat-diet-induced obese rats. This review will provide updated information regarding the role of COX-2-derived signals in the regulation of energy metabolism and the pathogenesis of obesity and MS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Prostaglandins). EC 1-14-99-1 (Cyclooxygenase 2).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20133115
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chan&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=The+Dualistic+Effect+of+COX-2-Mediated+Signaling+in+Obesity+and+Insulin+Resistance.&volume=20&issue=13&spage=3115&epage=&date=2019&doi=10.3390%2Fijms20133115&pmid=31247902&sid=OVID:medline
+
+<1605>
+Unique Identifier
+ 31246368
+Title
+ Effect of semaglutide on liver enzymes and markers of inflammation in subjects with type 2 diabetes and/or obesity.
+Source
+ Alimentary Pharmacology & Therapeutics. 50(2):193-203, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Newsome P; Francque S; Harrison S; Ratziu V; Van Gaal L; Calanna S; Hansen M; Linder M; Sanyal A
+Author NameID
+ Newsome, Philip; ORCID: https://orcid.org/0000-0001-6085-3652
+ Sanyal, Arun; ORCID: https://orcid.org/0000-0001-8682-5748
+Authors Full Name
+ Newsome, Philip; Francque, Sven; Harrison, Stephen; Ratziu, Vlad; Van Gaal, Luc; Calanna, Salvatore; Hansen, Morten; Linder, Martin; Sanyal, Arun.
+Institution
+ Newsome, Philip. National Institute for Health Research Birmingham Biomedical Research Centre and Liver Unit at University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
+ Newsome, Philip. Centre for Liver & Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
+ Francque, Sven. Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, Antwerp, Belgium.
+ Harrison, Stephen. Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
+ Ratziu, Vlad. ICAN - Institute for Cardiometabolism and Nutrition, Hopital Pitie Salpetriere, Sorbonne University, Paris, France.
+ Van Gaal, Luc. Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Antwerp, Belgium.
+ Calanna, Salvatore. Novo Nordisk A/S, Soborg, Denmark.
+ Hansen, Morten. Novo Nordisk A/S, Soborg, Denmark.
+ Linder, Martin. Novo Nordisk A/S, Soborg, Denmark.
+ Sanyal, Arun. Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Alanine Transaminase/me [Metabolism]
+ *Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/pc [Prevention & Control]
+ Clinical Trials, Phase II as Topic
+ Clinical Trials, Phase III as Topic
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Double-Blind Method
+ Female
+ Glucagon-Like Peptide 1/aa [Analogs & Derivatives]
+ *Glucagon-Like Peptides/pd [Pharmacology]
+ Glucagon-Like Peptides/tu [Therapeutic Use]
+ Humans
+ Hypoglycemic Agents/pd [Pharmacology]
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Inflammation/co [Complications]
+ Inflammation/dt [Drug Therapy]
+ *Inflammation/me [Metabolism]
+ *Liver/de [Drug Effects]
+ Liver/en [Enzymology]
+ Liver/me [Metabolism]
+ Male
+ Middle Aged
+ Multicenter Studies as Topic/sn [Statistics & Numerical Data]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pc [Prevention & Control]
+ Obesity/co [Complications]
+ *Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Randomized Controlled Trials as Topic/sn [Statistics & Numerical Data]
+ Retrospective Studies
+ Weight Reduction Programs
+ Young Adult
+Abstract
+ BACKGROUND: Obesity and type 2 diabetes are drivers of non-alcoholic fatty liver disease (NAFLD). Glucagon-like peptide-1 analogues effectively treat obesity and type 2 diabetes and may offer potential for NAFLD treatment.
+
+ AIM: To evaluate the effect of the glucagon-like peptide-1 analogue, semaglutide, on alanine aminotransferase (ALT) and high-sensitivity C-reactive protein (hsCRP) in subjects at risk of NAFLD.
+
+ METHODS: Data from a 104-week cardiovascular outcomes trial in type 2 diabetes (semaglutide 0.5 or 1.0 mg/week) and a 52-week weight management trial (semaglutide 0.05-0.4 mg/day) were analysed. Treatment ratios vs placebo were estimated for ALT (both trials) and hsCRP (weight management trial only) using a mixed model for repeated measurements, with or without adjustment for change in body weight.
+
+ RESULTS: Elevated baseline ALT (men >30 IU/L; women >19 IU/L) was present in 52% (499/957) of weight management trial subjects. In this group with elevated ALT, end-of-treatment ALT reductions were 6%-21% (P<0.05 for doses>=0.2 mg/day) and hsCRP reductions 25%-43% vs placebo (P < 0.05 for 0.2 and 0.4 mg/day). Normalisation of elevated baseline ALT occurred in 25%-46% of weight management trial subjects, vs 18% on placebo. Elevated baseline ALT was present in 41% (1325/3268) of cardiovascular outcomes trial subjects. In this group with elevated ALT, no significant ALT reduction was noted at end-of-treatment for 0.5 mg/week, while a 9% reduction vs placebo was seen for 1.0 mg/week (P = 0.0024). Treatment ratios for changes in ALT and hsCRP were not statistically significant after adjustment for weight change.
+
+ CONCLUSIONS: Semaglutide significantly reduced ALT and hsCRP in clinical trials in subjects with obesity and/or type 2 diabetes. Copyright © 2019 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hypoglycemic Agents). 53AXN4NNHX (semaglutide). 62340-29-8 (Glucagon-Like Peptides). 89750-14-1 (Glucagon-Like Peptide 1). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fapt.15316
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Newsome&issn=0269-2813&title=Alimentary+Pharmacology+%26+Therapeutics&atitle=Effect+of+semaglutide+on+liver+enzymes+and+markers+of+inflammation+in+subjects+with+type+2+diabetes+and%2For+obesity.&volume=50&issue=2&spage=193&epage=203&date=2019&doi=10.1111%2Fapt.15316&pmid=31246368&sid=OVID:medline
+
+<1606>
+Unique Identifier
+ 31245006
+Title
+ Effect of dose of behavioral weight loss treatment on glycemic control in adults with prediabetes.
+Source
+ BMJ Open Diabetes Research & Care. 7(1):e000653, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bauman V; Ariel-Donges AH; Gordon EL; Daniels MJ; Xu D; Ross KM; Limacher MC; Perri MG
+Author NameID
+ Ariel-Donges, Aviva H; ORCID: https://orcid.org/0000-0002-7504-8784
+ Gordon, Eliza L; ORCID: https://orcid.org/0000-0001-8206-3387
+ Ross, Kathryn M; ORCID: https://orcid.org/0000-0002-3628-766X
+ Perri, Michael G; ORCID: https://orcid.org/0000-0003-3651-1542
+Authors Full Name
+ Bauman, Viviana; Ariel-Donges, Aviva H; Gordon, Eliza L; Daniels, Michael J; Xu, Dandan; Ross, Kathryn M; Limacher, Marian C; Perri, Michael G.
+Institution
+ Bauman, Viviana. Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
+ Ariel-Donges, Aviva H. Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
+ Gordon, Eliza L. Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
+ Daniels, Michael J. Department of Statistics, University of Florida, Gainesville, Florida, USA.
+ Xu, Dandan. Department of Statistics and Data Sciences, University of Texas at Austin, Austin, Texas, USA.
+ Ross, Kathryn M. Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
+ Limacher, Marian C. Department of Medicine, University of Florida, Gainesville, Florida, USA.
+ Perri, Michael G. Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Behavior Therapy/mt [Methods]
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Body Weight
+ Case-Control Studies
+ Diabetes Mellitus, Type 2/px [Psychology]
+ *Diabetes Mellitus, Type 2/th [Therapy]
+ Energy Intake
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Male
+ Middle Aged
+ Obesity/px [Psychology]
+ *Obesity/th [Therapy]
+ Prediabetic State/px [Psychology]
+ *Prediabetic State/th [Therapy]
+ Treatment Outcome
+ *Weight Loss
+ Young Adult
+Keyword Heading
+ behavioral treatment
+ glycemic control
+ obesity
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: This study examined the effects of three doses of behavioral weight loss treatment, compared with a nutrition education control group, on changes in glycemic control in individuals with obesity and prediabetes.
+
+ Research design and methods: The study included 287 adults (77% female, 81% White; mean (SD) age=54.1 (10.5) years, body mass index=36.3 (3.9) kg/m2, and hemoglobin A1c (HbA1c)=5.9 (0.2%)). Participants were randomized to one of three behavioral treatment doses (high=24 sessions, moderate=16 sessions, or low=8 sessions) or to an education group (control=8 sessions). Changes in HbA1c, fasting glucose, and body weight were assessed from baseline to 6 months.
+
+ Results: Mean (99.2% credible interval (CI)) reductions in HbA1c were 0.11% (0.07% to 0.16%), 0.08% (0.03% to 0.13%), 0.03% (-0.01% to 0.07%), and 0.02% (-0.02% to 0.07%), for the high, moderate, low, and control conditions, respectively. Mean (CI) reductions in fasting blood glucose were 0.26 mmol/L (0.14 to 0.39), 0.09 mmol/L (0 to 0.19), 0.01 mmol/L (-0.07 to 0.09), and 0.04 mmol/L (-0.03 to 0.12) for the high, moderate, low, and control conditions, respectively. The high-dose treatment produced significantly greater reductions in HbA1c and fasting blood glucose than the low-dose and control conditions (posterior probabilities (pp)<0.001); no other significant between-group differences were observed. Mean (CI) reductions in body weight were 10.91 kg (9.30 to 12.64), 10.08 kg (8.38 to 11.72), 6.35 kg (5.19 to 7.69), and 3.82 kg (3.04 to 4.54) for the high, moderate, low, and control conditions, respectively. All between-group differences in 6-month weight change were significant (pps<0.001) except for the high-dose versus moderate-dose comparison.
+
+ Conclusion: For adults with obesity and prediabetes a high dose of behavioral treatment involving 24 sessions over 6 months may be needed to optimize improvements in glycemic control.
+
+ Trial registration number: NCT00912652.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1136%2fbmjdrc-2019-000653
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bauman&issn=2052-4897&title=BMJ+Open+Diabetes+Research+%26+Care&atitle=Effect+of+dose+of+behavioral+weight+loss+treatment+on+glycemic+control+in+adults+with+prediabetes.&volume=7&issue=1&spage=e000653&epage=&date=2019&doi=10.1136%2Fbmjdrc-2019-000653&pmid=31245006&sid=OVID:medline
+
+<1607>
+Unique Identifier
+ 31241556
+Title
+ Center Variation and Risk Factors for Failure to Complete 6 Month Postdonation Follow-up Among Obese Living Kidney Donors.
+Source
+ Transplantation. 103(7):1450-1456, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Reed RD; MacLennan PA; Shelton BA; Mustian MN; Blackburn J; Smith SC; Terry KB; Grant R; Sawinski D; Locke JE
+Authors Full Name
+ Reed, Rhiannon D; MacLennan, Paul A; Shelton, Brittany A; Mustian, Margaux N; Blackburn, Justin; Smith, Sharmene C; Terry, Kristin B; Grant, Raynesha; Sawinski, Deirdre; Locke, Jayme E.
+Institution
+ Reed, Rhiannon D. Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
+ MacLennan, Paul A. Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
+ Shelton, Brittany A. Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
+ Mustian, Margaux N. Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
+ Blackburn, Justin. Department of Health Policy and Management, Indiana University-Purdue University Indianapolis, Indianapolis, IN.
+ Smith, Sharmene C. Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
+ Terry, Kristin B. Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
+ Grant, Raynesha. Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
+ Sawinski, Deirdre. Comprehensive Transplant Center, University of Pennsylvania, Philadelphia, PA.
+ Locke, Jayme E. Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
+MeSH Subject Headings
+ Adult
+ *Aftercare/td [Trends]
+ Biomarkers/bl [Blood]
+ Creatinine/bl [Blood]
+ *Donor Selection/td [Trends]
+ Female
+ *Healthcare Disparities/td [Trends]
+ Hospitals, High-Volume/td [Trends]
+ Hospitals, Low-Volume/td [Trends]
+ Humans
+ Kidney Failure, Chronic/bl [Blood]
+ Kidney Failure, Chronic/di [Diagnosis]
+ Kidney Failure, Chronic/et [Etiology]
+ Kidney Transplantation/ae [Adverse Effects]
+ *Kidney Transplantation/td [Trends]
+ *Living Donors
+ Male
+ Middle Aged
+ Nephrectomy/ae [Adverse Effects]
+ *Nephrectomy
+ *Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Practice Patterns, Physicians'/td [Trends]
+ Registries
+ Retrospective Studies
+ Risk Factors
+ Time Factors
+ Treatment Outcome
+ United States
+Abstract
+ BACKGROUND: Living kidney donors in the United States who were obese at donation are at increased risk of end-stage renal disease and may benefit from intensive postdonation follow-up. However, they are less likely to have complete follow-up data. Center variation and risk factors for incomplete follow-up are unknown.
+
+ METHODS: Adult living kidney donors with obesity (body mass index, >=30 kg/m) at donation reported to the Scientific Registry of Transplant Recipients from January 2005 to July 2015 were included (n = 13 831). Donor characteristics were compared by recorded serum creatinine at 6 months postdonation, and multilevel logistic regression models were used to estimate odds of 6-month creatinine.
+
+ RESULTS: After adjustment, older age, female sex, and donation after implementation of new center follow-up requirements were associated with higher odds of 6-month creatinine, with lower odds for obese donors with a history of smoking, biologically related donors, and at centers with higher total living donor volume. 23% of variation in recorded 6-month serum creatinine among obese donors was attributed to center (intraclass correlation coefficient: 0.232, P < 0.001). The adjusted probability of 6-month creatinine by center ranged from 10% to 91.5%.
+
+ CONCLUSIONS: Tremendous variation in recorded 6-month postdonation serum creatinine exists among obese living donors, with high volume centers having the lowest probability of follow-up. Moreover, individual-level characteristics such as age, sex, and relationship to recipient were associated with recorded 6-month creatinine. Given increased risk for end-stage renal disease among obese living donors, center-level efforts targeted specifically at increasing postdonation follow-up among obese donors should be developed and implemented.
+Registry Number/Name of Substance
+ 0 (Biomarkers). AYI8EX34EU (Creatinine).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fTP.0000000000002508
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Reed&issn=0041-1337&title=Transplantation&atitle=Center+Variation+and+Risk+Factors+for+Failure+to+Complete+6+Month+Postdonation+Follow-up+Among+Obese+Living+Kidney+Donors.&volume=103&issue=7&spage=1450&epage=1456&date=2019&doi=10.1097%2FTP.0000000000002508&pmid=31241556&sid=OVID:medline
+
+<1608>
+Unique Identifier
+ 31235173
+Title
+ A quantitative, retrospective inquiry of the impact of a provider-guided low-carbohydrate, high-fat diet on adults in a wellness clinic setting.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):2314-2319, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Selby LM; Tobin BS; Conner BT; Gomez M; Busch G; Hauser J
+Authors Full Name
+ Selby, Lisa M; Tobin, Brenda S; Conner, Brian T; Gomez, Melissa; Busch, Garrett; Hauser, Jimmie.
+Institution
+ Selby, Lisa M. School of Nursing, Simmons University, 300 The Fenway, Boston, MA, 02115, United States; MountainView Physician Services, 4351 East Lohman Avenue, Suite 202, Las Cruces, NM, 88011, United States. Electronic address: lisa.selby@simmons.edu.
+ Tobin, Brenda S. School of Nursing, Simmons University, 300 The Fenway, Boston, MA, 02115, United States. Electronic address: brenda.tobin2@simmons.edu.
+ Conner, Brian T. School of Nursing, Simmons University, 300 The Fenway, Boston, MA, 02115, United States. Electronic address: brian.conner@simmons.edu.
+ Gomez, Melissa. MountainView Physician Services, 4351 East Lohman Avenue, Suite 202, Las Cruces, NM, 88011, United States. Electronic address: melissa.gomez@mountainviewregional.com.
+ Busch, Garrett. MountainView Physician Services, 4351 East Lohman Avenue, Suite 202, Las Cruces, NM, 88011, United States. Electronic address: garrett.busch@mountainviewregional.com.
+ Hauser, Jimmie. MountainView Physician Services, 4351 East Lohman Avenue, Suite 202, Las Cruces, NM, 88011, United States. Electronic address: jimmie.hauser@mountainviewregional.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Diet, Carbohydrate-Restricted
+ *Diet, High-Fat
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ *Health Personnel
+ Humans
+ Male
+ Middle Aged
+ *Obesity/dh [Diet Therapy]
+ *Overweight/dh [Diet Therapy]
+ Prognosis
+ Treatment Outcome
+ Young Adult
+Keyword Heading
+ Cardiovascular
+ Diabetes
+ Diet
+ Ketogenic
+ Obesity
+ Primary care
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Despite the critical status of obesity as an epidemic chronic illness in the United States contributing toward diabetic and cardiovascular disease as well as early preventable death, treatment approaches in primary care remain in conflict; providers lack evidence-based guidelines toward impactful disease management, particularly from dietary approaches. This study aimed to evaluate the impact of initiation of a 5-10% low-carbohydrate, 75-85% high-fat diet on specific clinical indicators of obesity, a metabolic disease associated with increased morbidity and mortality, at baseline and six months in an adult population.
+
+ MATERIALS AND METHODS: Utilizing a retrospective electronic medical record data collection protocol, one hundred patients with obesity in a wellness clinic in the Southwestern United States between 2017 and 2018 prescribed a low-carbohydrate, high-fat diet were selected via simple random sampling. Measurements of body mass index, hemoglobin A1C, and lipid levels were extracted at baseline and six months after initiation.
+
+ RESULTS: Mean differences of each biomarker at baseline and six months were analyzed utilizing paired samples t-testing in SPSS and demonstrated statistically-significant improvement across each category. Body mass index decreased, hemoglobin A1C decreased, and each of three clinically-relevant lipid level measurements moved numerically toward normal-value ranges.
+
+ CONCLUSION: Data from this sample of 100 patients with obesity suggest body weight, diabetic, and cardiovascular status improvement from a low-carbohydrate, high-fat diet over six months, affording a prescriptive nutrition option for primary care providers to consider prior to or as a complement to pharmacologic management. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.05.031
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Selby&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=A+quantitative%2C+retrospective+inquiry+of+the+impact+of+a+provider-guided+low-carbohydrate%2C+high-fat+diet+on+adults+in+a+wellness+clinic+setting.&volume=13&issue=3&spage=2314&epage=2319&date=2019&doi=10.1016%2Fj.dsx.2019.05.031&pmid=31235173&sid=OVID:medline
+
+<1609>
+Unique Identifier
+ 31235170
+Title
+ "Sex hormone independent associations between insulin resistance and thyroid status -a gender based biochemical study on clinically euthyroid non-obese, overweight and obese type 2 diabetics''.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):2286-2291, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jayanthi R; Srinivasan AR
+Authors Full Name
+ Jayanthi, Rajendran; Srinivasan, Abu Raghavan.
+Institution
+ Jayanthi, Rajendran. Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri BalajiVidyapeeth (Deemed to be University Accredited with A Grade by NAAC), Pondicherry, 607402, India.
+ Srinivasan, Abu Raghavan. Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri BalajiVidyapeeth (Deemed to be University Accredited with A Grade by NAAC), Pondicherry, 607402, India. Electronic address: srinivasanar@mgmcri.ac.in.
+MeSH Subject Headings
+ Adult
+ Aged
+ Anthropometry
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ *Gonadal Steroid Hormones/bl [Blood]
+ Humans
+ India/ep [Epidemiology]
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prognosis
+ *Thyroid Gland/me [Metabolism]
+Keyword Heading
+ Anthropometry
+ Insulin resistance
+ Sex hormones
+ T2DM
+ Thyroid hormones
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Studies indicate that type 2 diabetes mellitus (T2DM) might contribute to the development of thyroid disorders (TD). However, few gender based reports are available describing therelationship between T2DM and TD in clinically euthyroid, anthropometry specified groups of type 2 diabetics. The aim of this study was to relategender based biochemical changes in anthropometry specified, clinically euthyroid type 2 diabetics.
+
+ METHODOLOGY: The study was carried out on clinically euthyroid type 2 diabetics (male n=269; female n=301) at a tertiary health care unit in Pondicherry, South India. Three groups were segregatedbased on Body mass Index: 153 non-obese type 2 diabetics (BMI=18.5-24.99), 291 overweight type 2 diabetics (BMI=25-29.99) and 126 obese type 2 diabetics (BMI>=30). Biochemical parameters included glycated hemoglobin, insulin resistance, Cortisol and Thyroid profile.
+
+ RESULTS: The study had included clinically euthyroid type 2 diabetics (52.8% females and 47.2% males). Statistically significant associationsweredifferently observed between insulin resistance (dependent variable) andother independent variables, irrespective of sex hormone status. Total protein was negatively related in non -obese male type 2 diabetics (R=0.780); Triiodothyronine was inversely associated in overweight males, whereas cortisol and the divalent cations (Zinc and Magnesium) depicted positive association (R=0.555) in the same group (overweight), butcortisol in non -obese female type 2 diabeticswas negative (R=0.742); Glycated hemoglobin and calcium exhibited positive relationshipin obese type 2 female diabetics (R=0.771). .
+
+ CONCLUSION: Our study has revealed distinctive relationship between T2DM and TD in the anthropometry specified, clinically euthyroid and gender based type 2 diabetics, independent of the sex hormones. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Gonadal Steroid Hormones). 0 (Insulin). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.05.017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jayanthi&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=%22Sex+hormone+independent+associations+between+insulin+resistance+and+thyroid+status+-a+gender+based+biochemical+study+on+clinically+euthyroid+non-obese%2C+overweight+and+obese+type+2+diabetics%27%27.&volume=13&issue=3&spage=2286&epage=2291&date=2019&doi=10.1016%2Fj.dsx.2019.05.017&pmid=31235170&sid=OVID:medline
+
+<1610>
+Unique Identifier
+ 31235162
+Title
+ Effect of a 24-week weight management program on serum leptin level in correlation to anthropometric measures in obese female: A randomized controlled clinical trial.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):2230-2235, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rashad NM; Sayed SE; Sherif MH; Sitohy MZ
+Authors Full Name
+ Rashad, Nearmeen M; Sayed, Sally E; Sherif, Mohamed H; Sitohy, Mahmoud Z.
+Institution
+ Rashad, Nearmeen M. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Electronic address: nrashad78@yahoo.com.
+ Sayed, Sally E. Biochemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
+ Sherif, Mohamed H. Organic Chemistry Department, Faculty of Science Zagazig University, Zagazig, Egypt.
+ Sitohy, Mahmoud Z. Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Body Composition
+ *Body Mass Index
+ Case-Control Studies
+ Energy Intake
+ Female
+ Follow-Up Studies
+ Humans
+ *Leptin/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/th [Therapy]
+ Prognosis
+ Waist-Hip Ratio
+ *Weight Loss
+ *Weight Reduction Programs/mt [Methods]
+Keyword Heading
+ Anthropometric
+ FMI
+ Leptin
+ Mediterranean diet
+ Obesity
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a major contributor to preventable disease and death across the globe. Obesity is complex. Although its risk factors are myriad and compounding, there is an urgent need for a deeper understanding of the way risk factors interact with each other. Leptin is a peptide regulates food intake and body weight. However, the notion of leptin as an anti-obesity hormone was called into question because obesity is typically associated with high leptin levels and not leptin deficiency thus, we aimed to measure leptin levels in obese female in correlation to anthropometric measures and to evaluate the impact of weight loss on its level and metabolic parameters.
+
+ SUBJECT AND METHODS: case-control study enrolled 40 control groups, 50 obese women. We measured anthropometric measures BMI, Waist/hip ratio (WHR). Fat mass index (FMI%) and free fat mass index (FFMI%) were assessed by dual energy X-Ray absorptiometry (DEXA) The serum levels of leptin were measured by ELISA.
+
+ RESULTS: Our results revealed that serum leptin levels were higher in obese women compared to controls. Moreover, it was positively correlated to anthropometric measures, glycemic and lipid profile. Linear regression analysis revealed that BMI was the main independent studied parameters associated with serum leptin level among other clinical and laboratory biomarkers. Interestingly, after 12 weeks of following the Mediterranean diet (MD)-based weight loss program, serum leptin levels were decreased. Logistic regression analysis was performed to detect the main predictors' biomarkers associated with weight loss among obese women. We found that serum leptin and FMI% were an independent predictor of response with odds ratios of 1.69 and 1.64 respectively (P<0.001), Receiver operating characteristic analyses revealed that the AUC of serum leptin in discriminating obese women from lean ones was 0.893 (95% CI=0.815-0.917) with sensitivity=90%, specificity=96%, and the cutoff values was 36.32ng/ml.
+
+ CONCLUSION: Serum leptin could be a valuable diagnostic marker of obesity and its comorbidities. Moreover, significant weight loss leads to decrease serum leptin levels and improvement of glycemic and lipid profiles. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.05.027
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rashad&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Effect+of+a+24-week+weight+management+program+on+serum+leptin+level+in+correlation+to+anthropometric+measures+in+obese+female%3A+A+randomized+controlled+clinical+trial.&volume=13&issue=3&spage=2230&epage=2235&date=2019&doi=10.1016%2Fj.dsx.2019.05.027&pmid=31235162&sid=OVID:medline
+
+<1611>
+Unique Identifier
+ 31235149
+Title
+ Evaluation of muscle mass in obesity, prediabetes and diabetes mellitus by different equations used for the measurement of muscle mass.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):2148-2151, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dabak MR; Sevinc E; Tuzun S; Gun EO
+Authors Full Name
+ Dabak, Mustafa Resat; Sevinc, Elif; Tuzun, Sabah; Gun, Emine Ozel.
+Institution
+ Dabak, Mustafa Resat. Kartal Dr Lutfi Kirdar Training and Research Hospital, Department of Family Medicine, Istanbul, Turkey.
+ Sevinc, Elif. Kartal Dr Lutfi Kirdar Training and Research Hospital, Department of Family Medicine, Istanbul, Turkey.
+ Tuzun, Sabah. Kartal Dr Lutfi Kirdar Training and Research Hospital, Department of Family Medicine, Istanbul, Turkey. Electronic address: sabahtuzun@gmail.com.
+ Gun, Emine Ozel. Kartal Dr Lutfi Kirdar Training and Research Hospital, Department of Family Medicine, Istanbul, Turkey.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Body Composition
+ Body Mass Index
+ *Diabetes Mellitus/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Incidence
+ Male
+ Middle Aged
+ *Muscle, Skeletal/pp [Physiopathology]
+ *Obesity/pp [Physiopathology]
+ *Prediabetic State/pp [Physiopathology]
+ Prognosis
+ Retrospective Studies
+ *Sarcopenia/ep [Epidemiology]
+ Sarcopenia/me [Metabolism]
+ Sarcopenia/pa [Pathology]
+ Turkey/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ Diabetes Mellitus
+ Obesity
+ Prediabetes
+ Sarcopenia
+ Skeletal Muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Insulin resistance is one of risk factors for sarcopenia and there is no specific equation for the measurement of muscle mass. The present study aimed to evaluate muscle mass in the patients with obesity, prediabetes (PDM) and type 2 diabetes mellitus (DM) by different equations for the measurement of muscle mass.
+
+ METHODS: Obese patients aged 18-65 years old, who presented between 2013 and 2015 were reviewed and they were separated into three groups as obese, prediabetes (PDM) and diabetes mellitus (DM). Height, body weight, body mass index (BMI), sum of the appendicular lean masses (ALM) were measured in all participants. Body muscle mass ratio was calculated as the total muscle mass divided by the body weight, and skeletal muscle index was calculated as the total muscle mass divided by the square of the height. In addition, ALM/weight, ALM/height2 and ALM/BMI ratios were also evaluated.
+
+ RESULTS: A total of 1107 participants, of whom 666 (60.2%) were female, were enrolled into the study. Of the participants, 288 (%26.02) had obesity, 524 (%47.33) had PDM and 295 (26.65%) had DM. There was a significant difference in ALM/BMI ratio between the three groups for both genders (p=0.003 for female and p=0.003 for male). ALM/weight ratio and body muscle mass ratio were decreased between groups in female, whereas it was no difference in male (p=0.003, p<0.001 for females, respectively; p=0.802, p=0.840 for males, respectively).
+
+ CONCLUSIONS: ALM/BMI may be more accurate for the evaluation of muscle mass in middle-aged obese, PDM and DM subjects. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.05.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dabak&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Evaluation+of+muscle+mass+in+obesity%2C+prediabetes+and+diabetes+mellitus+by+different+equations+used+for+the+measurement+of+muscle+mass.&volume=13&issue=3&spage=2148&epage=2151&date=2019&doi=10.1016%2Fj.dsx.2019.05.007&pmid=31235149&sid=OVID:medline
+
+<1612>
+Unique Identifier
+ 31235142
+Title
+ Proinsulin/insulin ratio as a predictor of insulin resistance and B-cell dysfunction in obese Egyptians ((insulin resistance & B-cell dysfunction in obese Egyptians)).
+Source
+ Diabetes & Metabolic Syndrome. 13(3):2094-2096, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ El Shabrawy AM; Elbana KA; Abdelsalam NM
+Authors Full Name
+ El Shabrawy, Arafa M; Elbana, Khaled A; Abdelsalam, Noha M.
+Institution
+ El Shabrawy, Arafa M. Endocrinology and Diabetes Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Electronic address: arafashabrawy@ymail.com.
+ Elbana, Khaled A. Endocrinology and Diabetes Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
+ Abdelsalam, Noha M. Public Health and Preventive Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Body Weight
+ Case-Control Studies
+ Egypt/ep [Epidemiology]
+ Fasting
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ Insulin-Secreting Cells/me [Metabolism]
+ *Insulin-Secreting Cells/pa [Pathology]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ *Proinsulin/bl [Blood]
+Keyword Heading
+ Beta cell dysfunction
+ Insulin resistance
+ Obesity
+ Pro insulin /insulin ratio
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Insulin resistance (IR) and beta-cell dysfunction are key pathological features of type 2 diabetes mellitus, the aim of this study was to investigate the role of proinsulin level and proinsulin/insulin ratio in early prediction of beta cell dysfunction and insulin resistance in obese Egyptian adolescent.
+
+ PATIENTS AND METHODS: This Case control study was conducted from June 2017 to March 2018. Total of 60 patients were divided into 2 groups after exclusion of patients with diabetes: normal body weight group and Obese group. Demographic, clinical data were collected. Laboratory investigation included fasting insulin, proinsulin, and estimation of HOMA IR and HOMA-B were done.
+
+ RESULTS: There are highly statistically significant increase in obese group regarding insulin, proinsulin, proinsulin/insulin ratio and HOMA-IR while there is significant decrease in HOMA-B in this group. The best cutoff value of Proinsulin in prediction of beta cell function was >=7.829pmol/L with sensitivity 95.8, specificity 72.2. The best cutoff value of Proinsulin/insulin ratio in prediction of insulin resistance was >=0.1545 with sensitivity 87.5, specificity 61.1.
+
+ CONCLUSION: both beta cell dysfunction and insulin resistance increased in obese group and so increased risk of type 2 diabetes. We found that Pro insulin/insulin ratio is a significant predictor for insulin resistance and Proinsulin is good predictor for beta cell dysfunction. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 9035-68-1 (Proinsulin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.04.044
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=El+Shabrawy&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Proinsulin%2Finsulin+ratio+as+a+predictor+of+insulin+resistance+and+B-cell+dysfunction+in+obese+Egyptians+%28%28insulin+resistance+%26+B-cell+dysfunction+in+obese+Egyptians%29%29.&volume=13&issue=3&spage=2094&epage=2096&date=2019&doi=10.1016%2Fj.dsx.2019.04.044&pmid=31235142&sid=OVID:medline
+
+<1613>
+Unique Identifier
+ 31235141
+Title
+ Kisspeptin and body weight homeostasis in relation to phenotypic features of polycystic ovary syndrome; metabolic regulation of reproduction.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):2086-2092, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rashad NM; Al-Sayed RM; Yousef MS; Saraya YS
+Authors Full Name
+ Rashad, Nearmeen M; Al-Sayed, Radwa M; Yousef, Mohammed S; Saraya, Yasser S.
+Institution
+ Rashad, Nearmeen M. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Electronic address: nrashad78@yahoo.com.
+ Al-Sayed, Radwa M. Physiology Department, Faculty of Medicine-Zagazig University, Egypt.
+ Yousef, Mohammed S. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
+ Saraya, Yasser S. Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Mass Index
+ *Body Weight
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ *Homeostasis
+ Humans
+ Insulin Resistance
+ *Kisspeptins/bl [Blood]
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ *Polycystic Ovary Syndrome/ep [Epidemiology]
+ Polycystic Ovary Syndrome/et [Etiology]
+ Prognosis
+ *Reproduction
+ Thinness
+Keyword Heading
+ Body weight homeostasis
+ Kisspeptin
+ PCOS
+ Phenotypic features
+ Reproduction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by a diverse collection of reproductive and metabolic abnormalities. kisspeptin (KISS) is novel peptides associated with regulation of metabolism, food intake, puberty and reproduction. The aim of the present study was to estimate KISS level in patients with PCOS, and to evaluate the possible relationship between KISS level with anthropometric measures as well as clinic-morphological features of PCOS.
+
+ MATERIALS AND METHODS: cross section control study enrolled 90 control group and 105 patients with PCOS and they were stratified according to their body mass index (BMI) to; underweight (n=9, BMI <19), normal weight (n=25, BMI=19.1-25), over weight (n=34,BMI=25.1-30), obese grade I (n=12, BMI=30.1-35) , obese grade II (n=13, BMI 35.1-40) and obese grade III (n=12, BMI>40). Circulating KISS levels were measured using ELISA.
+
+ RESULTS: Our results revealed that, KISS levels were higher in PCOS patients compared to controls. Among PCOS group, there were significant lower level of KISS levels in underweight, overweight and obese compared to normal weight group. Even more importantly, KISS levels decreased with increasing of BMI as the following, grade I, grade II and grade III. Moreover, it was negatively correlated to anthropometric measures, glycemic, lipid profile and positively correlated the phenotype characteristics of PCOS. Linear regression test observed that hirsutism score, HOMA-IR and LH were the main predictors of KISS levels in PCOS.
+
+ CONCLUSION: circulating KISS is an important regulator of body weight and reproduction especially in PCOS women. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (KISS1 protein, human). 0 (Kisspeptins). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.04.017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rashad&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Kisspeptin+and+body+weight+homeostasis+in+relation+to+phenotypic+features+of+polycystic+ovary+syndrome%3B+metabolic+regulation+of+reproduction.&volume=13&issue=3&spage=2086&epage=2092&date=2019&doi=10.1016%2Fj.dsx.2019.04.017&pmid=31235141&sid=OVID:medline
+
+<1614>
+Unique Identifier
+ 31235138
+Title
+ Association of serum Interleukin-10, omentin-1 and visfatin concentration with metabolic risk factors in obese children.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):2069-2074, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Himani K; Vani G; Mishra S; Mahdi AA; Shally A
+Authors Full Name
+ Himani, Kulshrestha; Vani, Gupta; Mishra, Supriya; Mahdi, Abbas Ali; Shally, Awasthi.
+Institution
+ Himani, Kulshrestha. Department of Physiology, King George's Medical University, Lucknow, India.
+ Vani, Gupta. Department of Physiology, King George's Medical University, Lucknow, India. Electronic address: vaniphysiology@gmail.com.
+ Mishra, Supriya. Department of Physiology, King George's Medical University, Lucknow, India.
+ Mahdi, Abbas Ali. Department of Biochemistry, King George's Medical University, Lucknow, India.
+ Shally, Awasthi. Department of Paediatric, King George's Medical University, Lucknow, India.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ Child
+ Cross-Sectional Studies
+ *Cytokines/bl [Blood]
+ Female
+ Follow-Up Studies
+ GPI-Linked Proteins/bl [Blood]
+ Humans
+ *Interleukin-10/bl [Blood]
+ *Lectins/bl [Blood]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ *Nicotinamide Phosphoribosyltransferase/bl [Blood]
+ *Obesity/co [Complications]
+ Prognosis
+ Risk Factors
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (GPI-Linked Proteins). 0 (IL10 protein, human). 0 (ITLN1 protein, human). 0 (Lectins). 130068-27-8 (Interleukin-10). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase). EC 2-4-2-12 (nicotinamide phosphoribosyltransferase, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.01.052
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Himani&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+of+serum+Interleukin-10%2C+omentin-1+and+visfatin+concentration+with+metabolic+risk+factors+in+obese+children.&volume=13&issue=3&spage=2069&epage=2074&date=2019&doi=10.1016%2Fj.dsx.2019.01.052&pmid=31235138&sid=OVID:medline
+
+<1615>
+Unique Identifier
+ 31235134
+Title
+ Association between waist circumference and waist-to-height ratio with insulin resistance biomarkers in normal-weight adults working in a private educational institution.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):2041-2047, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Urrunaga-Pastor D; De La Fuente-Carmelino L; Toro-Huamanchumo CJ; Perez-Zavala M; Benites-Zapata VA
+Authors Full Name
+ Urrunaga-Pastor, Diego; De La Fuente-Carmelino, Luciana; Toro-Huamanchumo, Carlos J; Perez-Zavala, Miriam; Benites-Zapata, Vicente A.
+Institution
+ Urrunaga-Pastor, Diego. Unidad de Investigacion para la Generacion y Sintesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru.
+ De La Fuente-Carmelino, Luciana. Unidad de Investigacion para la Generacion y Sintesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru.
+ Toro-Huamanchumo, Carlos J. Unidad de Investigacion para la Generacion y Sintesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru.
+ Perez-Zavala, Miriam. Unidad de Investigacion para la Generacion y Sintesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru.
+ Benites-Zapata, Vicente A. Unidad de Investigacion para la Generacion y Sintesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru. Electronic address: vbeniteszapata@gmail.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Cholesterol, HDL/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Hypertriglyceridemia/bl [Blood]
+ *Hypertriglyceridemia/ep [Epidemiology]
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Peru/ep [Epidemiology]
+ Prevalence
+ Prognosis
+ Risk Factors
+ Triglycerides/bl [Blood]
+ *Waist Circumference
+ *Waist-Height Ratio
+ Young Adult
+Keyword Heading
+ Cholesterol
+ HDL
+ Insulin resistance
+ Triglycerides
+ Waist circumference
+ Waist-height ratio
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To assess the association between elevated waist circumference (WC) and high waist-to-height ratio (WHtR) with insulin resistance biomarkers.
+
+ METHODS: We conducted an analytical cross-sectional study in normal-weight adults. Participants were divided in two groups according to WC or WHtR levels. We considered values of WC >= 90 in male participants and WC>=80 in adult women as elevated, and values of WHtR>=0.50 as high, for both genders. Our outcomes were high triglycerides to HDL-cholesterol (TG/HDL-C) ratio and elevated triglycerides and glucose index (TGI). We considered values of TG/HDL-C ratio >= 3 as high and TGI values>=8.37 as elevated. We elaborated crude and adjusted Poisson generalized linear models to evaluate the proposed associations and explored the gender interaction using stratified models. We reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI).
+
+ RESULTS: We analyzed 355 participants. The prevalence of elevated WC and high WHtR was 17.2% (n=61) and 33.2% (n=118), respectively, while the prevalence of high TG/HDL-C ratio and elevated TGI was 24.8% (n=88) and 12.7% (n=45), respectively. In the adjusted regression model, elevated WC was associated with high TG/HDL-C ratio only in female participants (aPR=3.61; 95%CI: 1.59-8.20). Similarly, high WHtR was associated with high TG/HDL-C ratio in women (aPR=2.54; 95%CI:1.08-5.97). We found an association with statistically marginal significance between elevated WC and elevated TGI in women (aPR=1.54; 95%CI: 0.95-2.50); as well as for the association between high WHtR and elevated TGI in male participants (aPR=1.87; 95%CI: 1.00-3.50).
+
+ CONCLUSION: Elevated WC and high WHtR were associated with a high TG/HDL-C ratio in women. It is necessary to perform prospective follow-up studies in the Peruvian population in order to corroborate our results. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.04.039
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Urrunaga-Pastor&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+between+waist+circumference+and+waist-to-height+ratio+with+insulin+resistance+biomarkers+in+normal-weight+adults+working+in+a+private+educational+institution.&volume=13&issue=3&spage=2041&epage=2047&date=2019&doi=10.1016%2Fj.dsx.2019.04.039&pmid=31235134&sid=OVID:medline
+
+<1616>
+Unique Identifier
+ 31235121
+Title
+ Evaluation of antioxidant defense markers in relation to hormonal and insulin parameters in women with polycystic ovary syndrome (PCOS): A case-control study.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):1957-1961, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fatima Q; Amin S; Kawa IA; Jeelani H; Manzoor S; Rizvi SM; Rashid F
+Authors Full Name
+ Fatima, Qudsia; Amin, Shajrul; Kawa, Iram Ashaq; Jeelani, Humira; Manzoor, Saika; Rizvi, Syeed Masuma; Rashid, Fouzia.
+Institution
+ Fatima, Qudsia. Department of Biochemistry, University of Kashmir, Srinagar, India; Department of Clinical Biochemistry, University of Kashmir, Srinagar, India.
+ Amin, Shajrul. Department of Biochemistry, University of Kashmir, Srinagar, India.
+ Kawa, Iram Ashaq. Department of Biochemistry, University of Kashmir, Srinagar, India; Department of Clinical Biochemistry, University of Kashmir, Srinagar, India.
+ Jeelani, Humira. Department of Biochemistry, University of Kashmir, Srinagar, India; Department of Clinical Biochemistry, University of Kashmir, Srinagar, India.
+ Manzoor, Saika. Department of Biochemistry, University of Kashmir, Srinagar, India; Department of Clinical Biochemistry, University of Kashmir, Srinagar, India.
+ Rizvi, Syeed Masuma. Department of Obstetrics and Gynecology, GMC, LD Hospital, Srinagar, India.
+ Rashid, Fouzia. Department of Clinical Biochemistry, University of Kashmir, Srinagar, India. Electronic address: rashid.fouzia@gmail.com.
+MeSH Subject Headings
+ Adult
+ *Antioxidants/me [Metabolism]
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ Glutathione Peroxidase/me [Metabolism]
+ Humans
+ Incidence
+ India/ep [Epidemiology]
+ *Insulin Resistance
+ Malondialdehyde/me [Metabolism]
+ *Obesity/co [Complications]
+ *Oxidative Stress
+ *Polycystic Ovary Syndrome/ep [Epidemiology]
+ Polycystic Ovary Syndrome/et [Etiology]
+ Polycystic Ovary Syndrome/me [Metabolism]
+ Polycystic Ovary Syndrome/pa [Pathology]
+ Prognosis
+ Prospective Studies
+ Young Adult
+Keyword Heading
+ Cardiovascular
+ Glutathione
+ Insulin resistance
+ Oxidative stress
+ Polycystic ovary syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Polycystic ovary syndrome (PCOS) is a composite heterogeneous condition with multifactorial etiology like genetic, environmental factors and oxidative stress. The exact pro-oxidant and antioxidant status in PCOS patients has not yet been fully established. We designed prospective study aimed to explore the association of PCOS and oxidative stress and examine the relationship of oxidative stress biomarkers with insulin parameters.
+
+ METHODS: Two groups were included: study group including 85 women with PCOS and control group of 85 healthy volunteers. Biochemical, Hormonal and insulin parameters were measured. Vitamin C, vitamin E, nitric oxide and activities of antioxidant enzymes were estimated using spectrophotometric methods.
+
+ RESULTS: Subjects with PCOS had poor antioxidant status as reflected by significantly low levels of glutathione, vitamin C & E and considerably increased activities of antioxidant enzymes like glutathione peroxidase, glutathione reductase and glutathione transferase as compared to those without PCOS. At the same time insulin levels were found to be significantly high and a positive correlation between oxidative stress and insulin parameters was observed in PCOS.
+
+ CONCLUSION: Low levels of antioxidants and increased oxidative stress with insulin resistance along with the observed correlation between these parameters suggest that women with PCOS are under oxidative stress which supports the concept that oxidative stress is involved in PCOS pathophysiology. Thus oxidative stress could be a contributory factor to future cardiovascular disease risk in these women in addition to known features like dyslipidemia, central obesity, etc. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 4Y8F71G49Q (Malondialdehyde). EC 1-11-1-9 (Glutathione Peroxidase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.04.032
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fatima&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Evaluation+of+antioxidant+defense+markers+in+relation+to+hormonal+and+insulin+parameters+in+women+with+polycystic+ovary+syndrome+%28PCOS%29%3A+A+case-control+study.&volume=13&issue=3&spage=1957&epage=1961&date=2019&doi=10.1016%2Fj.dsx.2019.04.032&pmid=31235121&sid=OVID:medline
+
+<1617>
+Unique Identifier
+ 31235119
+Title
+ Nutrition transition - Pattern IV: Leads Bangladeshi youth to the increasing prevalence of overweight and obesity.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):1943-1947, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al Muktadir MH; Islam MA; Amin MN; Ghosh S; Siddiqui SA; Debnath D; Islam MM; Ahmed T; Sultana F
+Authors Full Name
+ Al Muktadir, Mohammad Hamid; Islam, Md Ashraful; Amin, Mohammad Nurul; Ghosh, Supriya; Siddiqui, Shafayet Ahmed; Debnath, Dipti; Islam, Md Monirul; Ahmed, Tufael; Sultana, Farhana.
+Institution
+ Al Muktadir, Mohammad Hamid. Department of Public Health, American International University-Bangladesh, Dhaka, 1229, Bangladesh.
+ Islam, Md Ashraful. Department of Food Technology and Nutrition Science, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh.
+ Amin, Mohammad Nurul. Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh. Electronic address: amin.pharma07@gmail.com.
+ Ghosh, Supriya. Department of Food Technology and Nutrition Science, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh.
+ Siddiqui, Shafayet Ahmed. Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh.
+ Debnath, Dipti. Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh.
+ Islam, Md Monirul. Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.
+ Ahmed, Tufael. Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.
+ Sultana, Farhana. Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh. Electronic address: faru.pharma@gmail.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Bangladesh/ep [Epidemiology]
+ *Biomarkers/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Exercise
+ *Fast Foods/ae [Adverse Effects]
+ *Feeding Behavior
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ *Nutritional Status
+ *Obesity/ep [Epidemiology]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Overweight/ep [Epidemiology]
+ Overweight/et [Etiology]
+ Overweight/me [Metabolism]
+ Prevalence
+ Prognosis
+ Young Adult
+Keyword Heading
+ Fast food
+ Nutrition transition
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Fast food and soft drinks consumption leading to excess calorie intake coupled with lack of acceptable physical activity has augmented the prevalence of overweight and obesity among the world population for the past few eras. A cross-sectional study was carried out among 475 youth selected by systematic random sampling attending in 27 established public and private universities and colleges of Bangladesh. The study was aimed to evaluate habitual facts associated with the prevalence of overweight and obesity among Bangladeshi youth. The rates of fast food consumption (once/week) are 50.6%, 43.7%, and 53.3% in overweight, pre-obese and obese-1 respondents accordingly and the rates of soft drinks consumption (4-6 times/week) are 40.5%, 59.2%, and 73.3% respectively for the same subjects. Moreover, approximately 40.8% of the youth went to fast food restaurants at least once per week and 27.2% went regularly (2 times/week). Youth having fast foods 2 times/week, consuming soft drinks 3-4 times/week were more likely to be obese. Besides, obesity epidemic was observed among those who have not the habit of doing physical exercise. This study provides evidence of increasing trend and threat to overweight and obesity for the Bangladeshi youth. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.04.034
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al+Muktadir&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Nutrition+transition+-+Pattern+IV%3A+Leads+Bangladeshi+youth+to+the+increasing+prevalence+of+overweight+and+obesity.&volume=13&issue=3&spage=1943&epage=1947&date=2019&doi=10.1016%2Fj.dsx.2019.04.034&pmid=31235119&sid=OVID:medline
+
+<1618>
+Unique Identifier
+ 31235100
+Title
+ Risk stratification among metabolically unhealthy obese in independent physically inactive aged women.
+Source
+ Diabetes & Metabolic Syndrome. 13(3):1821-1825, 2019 May - Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adly NN; Abd-El-Gawad WM
+Authors Full Name
+ Adly, Nermien Naim; Abd-El-Gawad, Wafaa Mostafa.
+Institution
+ Adly, Nermien Naim. Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
+ Abd-El-Gawad, Wafaa Mostafa. Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: Wafaager@med.asu.edu.eg.
+MeSH Subject Headings
+ *Activities of Daily Living
+ Adiponectin/bl [Blood]
+ Aged
+ Basal Metabolism
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Cross-Sectional Studies
+ Energy Metabolism
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ Male
+ *Metabolic Syndrome/pp [Physiopathology]
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ *Risk Assessment/mt [Methods]
+ Risk Factors
+Keyword Heading
+ Aged
+ Insulin resistance
+ Metabolic syndrome
+ Metabolically unhealthy obese/overweight
+ Squared adiponectin level
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To determine whether or not adiponectin levels or basal metabolic rate (BMR) could predict worse risk stratification in patients with insulin resistance (IR) among metabolically healthy and unhealthy obese (MUHO) elderly females with Metabolic syndrome (MetS).
+
+ METHODS: A cross-sectional survey was conducted on 109 elderly females in geriatric nursing home with MetS. The participants were reclassified according to adiponectin levels and IR.
+
+ RESULTS: Group (1) (with IR, n=41) compared to group (2) (without IR, n=45) had lower squared adiponectin level and higher fat mass and fat percent (p value=0.037, 0.030, and 0.035 respectively). Quadratic adiponectin level was an independent predictor for better BMR in group (2) with higher R2 compared to linear adiponectin level (R2=0.19, 0.15 consecutively, p value=0.02, 0.008 consecutively) in group (2) rather than group (1). This revealed U-shaped relation between adiponectin level and BMR in group (2). By ROC curve, fat and lean percentages were statically significant predictors of IR between groups (1) and (2) (AUC=0.643, 0.636; p value=0.024, 0.032 Sensitivity=89.2%, 72.97%; and Specificity=55.1%, 24.48% respectively).
+
+ CONCLUSION: Current findings supported the possibility of risk stratification among MUHO individuals based on IR, squared adiponectin level, lean and fat percentages. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.04.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adly&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Risk+stratification+among+metabolically+unhealthy+obese+in+independent+physically+inactive+aged+women.&volume=13&issue=3&spage=1821&epage=1825&date=2019&doi=10.1016%2Fj.dsx.2019.04.007&pmid=31235100&sid=OVID:medline
+
+<1619>
+Unique Identifier
+ 31234301
+Title
+ Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring.
+Source
+ Nutrients. 11(6), 2019 Jun 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hafner H; Chang E; Carlson Z; Zhu A; Varghese M; Clemente J; Abrishami S; Bagchi DP; MacDougald OA; Singer K; Gregg B
+Author NameID
+ Chang, Eric; ORCID: https://orcid.org/0000-0001-9898-5773
+ Bagchi, Devika P; ORCID: https://orcid.org/0000-0002-2258-2289
+ Singer, Kanakadurga; ORCID: https://orcid.org/0000-0001-8278-3800
+ Gregg, Brigid; ORCID: https://orcid.org/0000-0002-1192-2997
+Authors Full Name
+ Hafner, Hannah; Chang, Eric; Carlson, Zach; Zhu, Allen; Varghese, Mita; Clemente, Jeremy; Abrishami, Simin; Bagchi, Devika P; MacDougald, Ormond A; Singer, Kanakadurga; Gregg, Brigid.
+Institution
+ Hafner, Hannah. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. hhafner@med.umich.edu.
+ Chang, Eric. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. changer@med.umich.edu.
+ Carlson, Zach. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. zcarlson@med.umich.edu.
+ Zhu, Allen. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. zhual@med.umich.edu.
+ Varghese, Mita. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. mvarghes@med.umich.edu.
+ Clemente, Jeremy. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. jerclem@med.umich.edu.
+ Abrishami, Simin. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. abrisham@med.umich.edu.
+ Bagchi, Devika P. Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA. dpbagchi@med.umich.edu.
+ MacDougald, Ormond A. Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA. macdouga@med.umich.edu.
+ Singer, Kanakadurga. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. ksinger@med.umich.edu.
+ Gregg, Brigid. Division of Diabetes, Endocrinology and Metabolism, Department of Pediatrics, University of Michigan Medicine, Ann Arbor, MI 48105, USA. greggb@med.umich.edu.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pp [Physiopathology]
+ *Adiposity
+ Age Factors
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Bone Marrow/me [Metabolism]
+ *Bone Marrow/pp [Physiopathology]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Female
+ Hyperglycemia/bl [Blood]
+ *Hyperglycemia/et [Etiology]
+ Hyperglycemia/pp [Physiopathology]
+ Inflammation/bl [Blood]
+ *Inflammation/et [Etiology]
+ Inflammation/pp [Physiopathology]
+ Inflammation Mediators/bl [Blood]
+ Insulin Resistance
+ *Lactation
+ Male
+ *Maternal Exposure/ae [Adverse Effects]
+ *Maternal Nutritional Physiological Phenomena
+ Mice, Inbred C57BL
+ Myeloid Cells/me [Metabolism]
+ Nutritional Status
+ Obesity/bl [Blood]
+ *Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ Risk Factors
+ Sex Factors
+ Time Factors
+ Weight Gain
+Keyword Heading
+ adipose tissue
+ developmental programming
+ inflammation
+ lactation
+ metabolism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Overnutrition during critical windows of development plays a significant role in life-long metabolic disease risk. Early exposure to excessive nutrition may result in altered programming leading to increased susceptibility to obesity, inflammation, and metabolic complications. This study investigated the programming effects of high-fat diet (HFD) exposure during the lactation period on offspring adiposity and inflammation. Female C57Bl/6J dams were fed a normal diet or a 60% HFD during lactation. Offspring were weaned onto a normal diet until 12 weeks of age when half were re-challenged with HFD for 12 weeks. Metabolic testing was performed throughout adulthood. At 24 weeks, adipose depots were isolated and evaluated for macrophage profiling and inflammatory gene expression. Males exposed to HFD during lactation had insulin resistance and glucose intolerance as adults. After re-introduction to HFD, males had increased weight gain and worsened insulin resistance and hyperglycemia. There was increased infiltration of pro-inflammatory CD11c+ adipose tissue macrophages, and bone marrow was primed to produce granulocytes and macrophages. Bone density was lower due to enhanced marrow adiposity. This study demonstrates that maternal HFD exposure during the lactational window programs offspring adiposity, inflammation, and impaired glucose homeostasis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11061393
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hafner&issn=2072-6643&title=Nutrients&atitle=Lactational+High-Fat+Diet+Exposure+Programs+Metabolic+Inflammation+and+Bone+Marrow+Adiposity+in+Male+Offspring.&volume=11&issue=6&spage=&epage=&date=2019&doi=10.3390%2Fnu11061393&pmid=31234301&sid=OVID:medline
+
+<1620>
+Unique Identifier
+ 31233515
+Title
+ Puerarin prevents high-fat diet-induced obesity by enriching Akkermansia muciniphila in the gut microbiota of mice.
+Source
+ PLoS ONE [Electronic Resource]. 14(6):e0218490, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wang L; Wu Y; Zhuang L; Chen X; Min H; Song S; Liang Q; Li AD; Gao Q
+Author NameID
+ Gao, Qian; ORCID: https://orcid.org/0000-0001-8189-6061
+Authors Full Name
+ Wang, Lei; Wu, Yongzheng; Zhuang, Lingjia; Chen, Xiufang; Min, Haiyan; Song, Shiyu; Liang, Qiao; Li, An-Dong; Gao, Qian.
+Institution
+ Wang, Lei. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+ Wu, Yongzheng. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+ Zhuang, Lingjia. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+ Chen, Xiufang. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+ Min, Haiyan. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+ Song, Shiyu. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+ Liang, Qiao. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+ Li, An-Dong. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+ Gao, Qian. Jiangsu Key Laboratory of Molecular Medicine and Center for Translational Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
+MeSH Subject Headings
+ Akkermansia
+ Animals
+ Biomarkers
+ Blood Glucose
+ Cell Line, Tumor
+ *Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ *Gastrointestinal Microbiome
+ Gene Expression Regulation
+ *Gram-Negative Bacterial Infections/mi [Microbiology]
+ Humans
+ Male
+ Mice
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Phenotype
+ *Verrucomicrobia
+Abstract
+ Growing evidence indicates that the gut microbiota plays a significant role in the pathophysiological processes of obesity and its related metabolic symptoms in the host. Puerarin, an active ingredient in the root of Pueraria lobate has been suggested to have a potent anti-obesity effect. Herein, we tested whether this effect of puerarin is associated with changes in the gut microbiota. In addition to reducing body weight, inflammation, and insulin resistance, puerarin administration significantly altered the composition of the gut microbiota. Notably, puerarin treatment greatly increased the abundance of Akkermansia muciniphila, a mucin-degrading bacterium known to be beneficial for host metabolism and significantly downregulated in high-fat diet-fed mice. Further experiments revealed that puerarin increased intestinal expression levels of Muc2 and Reg3g and protected intestinal barrier function (normal permeability) by increasing the expression of ZO-1 and occludin in vivo and in vitro. These data suggest that puerarin's enriching effect on A. muciniphila is mediated, at least in part, by a host cellular response to protect the host from diet-induced metabolic disorders and other diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0218490
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wang&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Puerarin+prevents+high-fat+diet-induced+obesity+by+enriching+Akkermansia+muciniphila+in+the+gut+microbiota+of+mice.&volume=14&issue=6&spage=e0218490&epage=&date=2019&doi=10.1371%2Fjournal.pone.0218490&pmid=31233515&sid=OVID:medline
+
+<1621>
+Unique Identifier
+ 31232044
+Title
+ Association between Serum Ferritin Level and Nonalcoholic Fatty Liver Disease in a Non-Obese Chinese Population: a Cross-Sectional Study.
+Source
+ Clinical Laboratory. 65(6), 2019 Jun 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yao J; Dai Y; Zhang J; Zhang X; Zheng R
+Authors Full Name
+ Yao, Jinmei; Dai, Yuying; Zhang, Juanwen; Zhang, Xuyao; Zheng, Ruoheng.
+MeSH Subject Headings
+ Adult
+ Asian People
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ China
+ Cross-Sectional Studies
+ Female
+ *Ferritins/bl [Blood]
+ Humans
+ Logistic Models
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/eh [Ethnology]
+ *Obesity/bl [Blood]
+ Obesity/eh [Ethnology]
+ Risk Factors
+Abstract
+ BACKGROUND: The aim of the study is to evaluate the cross-sectional association between serum ferritin level and nonalcoholic fatty liver disease (NAFLD) in a non-obese Chinese population.
+
+ METHODS: A cross-sectional study was performed among 1,020 non-obese subjects (body mass index < 25 kg/m2) who took their annual health examination at the First Affiliated Hospital, College of Medicine, Zhejiang University. Serum ferritin level and other clinical and laboratory parameters were measured in the population. Liver ultrasound examinations were performed to diagnose NAFLD.
+
+ RESULTS: Of the 1,020 enrolled participants, 148 (14.51%) fulfilled the diagnostic criteria for NAFLD. Subjects with NAFLD had a higher level of serum ferritin than individuals without NAFLD in non-obese subjects. Serum ferritin level was significantly and positively correlated with parameters of MS (BMI, SBP, TG and FPG) in NAFLD group. Stepwise logistic regression analysis showed that serum ferritin level was significantly associated with the risk factor for NAFLD. After adjusting for confounders, serum ferritin level was an independent factor predicting advanced fibrosis (FIB-4 >= 1.3) in NAFLD participants.
+
+ CONCLUSIONS: Increased serum ferritin level is significantly associated with NAFLD, and elevated serum ferritin level is an independent factor predicting advanced fibrosis for NAFLD in a non-obese Chinese population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-73-2 (Ferritins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.7754%2fClin.Lab.2019.181250
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yao&issn=1433-6510&title=Clinical+Laboratory&atitle=Association+between+Serum+Ferritin+Level+and+Nonalcoholic+Fatty+Liver+Disease+in+a+Non-Obese+Chinese+Population%3A+a+Cross-Sectional+Study.&volume=65&issue=6&spage=&epage=&date=2019&doi=10.7754%2FClin.Lab.2019.181250&pmid=31232044&sid=OVID:medline
+
+<1622>
+Unique Identifier
+ 31221297
+Title
+ Effect of whey protein supplementation combined with resistance training on body composition, muscular strength, functional capacity, and plasma-metabolism biomarkers in older women with sarcopenic obesity: A randomized, double-blind, placebo-controlled trial.
+Source
+ Clinical Nutrition ESPEN. 32:88-95, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nabuco HCG; Tomeleri CM; Fernandes RR; Sugihara Junior P; Cavalcante EF; Cunha PM; Antunes M; Nunes JP; Venturini D; Barbosa DS; Burini RC; Silva AM; Sardinha LB; Cyrino ES
+Authors Full Name
+ Nabuco, Hellen C G; Tomeleri, Crisieli M; Fernandes, Rodrigo R; Sugihara Junior, Paulo; Cavalcante, Edilaine F; Cunha, Paolo M; Antunes, Melissa; Nunes, Joao Pedro; Venturini, Danielle; Barbosa, Decio S; Burini, Roberto Carlos; Silva, Analiza M; Sardinha, Luis B; Cyrino, Edilson S.
+Institution
+ Nabuco, Hellen C G. Federal Institute of Science and Technology of Mato Grosso, Highway BR-364, Km 329, Cuiaba, MT 78106-970, Brazil; Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: hellen.nabuco@svc.ifmt.edu.br.
+ Tomeleri, Crisieli M. Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil; Faculty of Physical Education, University of Campinas, Erico Verissimo Avenue, Campinas, Sao Paulo 13083-970, Brazil. Electronic address: crisielitomeleri@gmail.com.
+ Fernandes, Rodrigo R. Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: rodrigo.r.fernandes@gmail.com.
+ Sugihara Junior, Paulo. Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: juniornutricao@hotmail.com.
+ Cavalcante, Edilaine F. Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: edilainefungari@gmail.com.
+ Cunha, Paolo M. Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: pcunha88@hotmail.com.
+ Antunes, Melissa. Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: melissa.antunes@hotmail.com.
+ Nunes, Joao Pedro. Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: joaonunes.jpn@hotmail.com.
+ Venturini, Danielle. Clinical Analyses Laboratory, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: danielle.venturini@bol.com.br.
+ Barbosa, Decio S. Clinical Analyses Laboratory, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: sabbatini2011@hotmail.com.
+ Burini, Roberto Carlos. Exercise and Nutrition Metabolism Center, Department of Public Health, Botucatu School of Medicine, UNESP, Botucatu, Sao Paulo 18618-687, Brazil. Electronic address: burini@fmb.unesp.br.
+ Silva, Analiza M. Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Estrada da Costa, Cruz Quebrada, Dafundo 1499-002, Portugal. Electronic address: analiza@fmh.ulisboa.pt.
+ Sardinha, Luis B. Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Estrada da Costa, Cruz Quebrada, Dafundo 1499-002, Portugal. Electronic address: lbsardinha55@gmail.com.
+ Cyrino, Edilson S. Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Highway Celso Garcia Cid, Londrina, Parana 86057-970, Brazil. Electronic address: edilsoncyrino@gmail.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers/me [Metabolism]
+ Body Composition
+ Dietary Supplements
+ Double-Blind Method
+ Female
+ Humans
+ Middle Aged
+ Muscle Strength
+ *Obesity
+ Resistance Training
+ Sarcopenia/bl [Blood]
+ *Sarcopenia/th [Therapy]
+ Treatment Outcome
+ *Whey Proteins/ad [Administration & Dosage]
+Keyword Heading
+ IL-6
+ Lean tissue
+ Obesity
+ Protein intake
+ Sarcopenia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUNDS & AIMS: Obesity and sarcopenia are independent illnesses associated with contemporary dietary and physical activity behaviors, aggravated by aging. Their coexistence is termed sarcopenic obesity (SO). Hence, increasing protein intake and resistance training (RT) are interventions that could counteract these illnesses. The objective of this investigation was to analyze the effects of whey protein (WP) supplementation associated with RT on body composition, muscular strength, functional capacity, and plasma-metabolism biomarkers in older women with SO.
+
+ METHODS: Twenty six sarcopenic (appendicular lean soft tissue ALST < 15.02 kg) obese (body fat mass >= 35%) older women were randomly assigned to receive daily, either 35 g of WP (WP group) or placebo (PLA group), combined with supervised RT (8 exercises, 3 x 8-12 rep, 3 times a week), during a 12-week protocol. Blood samples, blood pressure, dietary intake, functional capacity tests, the one repetition maximum (1RM) test, and body composition were assessed before and after the intervention period. Two-way analysis of variance for repeated measures was applied for comparisons.
+
+ RESULTS: The WP group presented greater (P < 0.05) increases in ALST (WP = 6.0% vs. PLA = 2.5%) and decreases in (P < 0.05) total (-3.3% vs. -0.3%) and trunk fat mass (WP = -5.1% vs. PLA = -1.1) and IL-6 (WP = -34.6% vs. PLA = 9.3%) compared with the PLA group. Both groups demonstrated improved (P < 0.05) scores for muscular strength, waist-hip ratio, functional capacity, and other plasma-metabolism biomarkers without significant differences between conditions.
+
+ CONCLUSION: Whey protein combined with RT increased ALST, and decreased total and trunk fat mass, improving sarcopenia and decreasing SO in older women, with a limited impact on inflammation. Registered under ClinicalTrials.gov Identifier ndegree NCT03752359. Copyright © 2019 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Whey Proteins).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.clnesp.2019.04.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nabuco&issn=2405-4577&title=Clinical+Nutrition+ESPEN&atitle=Effect+of+whey+protein+supplementation+combined+with+resistance+training+on+body+composition%2C+muscular+strength%2C+functional+capacity%2C+and+plasma-metabolism+biomarkers+in+older+women+with+sarcopenic+obesity%3A+A+randomized%2C+double-blind%2C+placebo-controlled+trial.&volume=32&issue=&spage=88&epage=95&date=2019&doi=10.1016%2Fj.clnesp.2019.04.007&pmid=31221297&sid=OVID:medline
+
+<1623>
+Unique Identifier
+ 31219798
+Title
+ Association of lipid profile and BMI Z-score in southern Iranian children and adolescents.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 32(8):827-835, 2019 Aug 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Habib A; Molayemat M; Habib A
+Authors Full Name
+ Habib, Ashkan; Molayemat, Mohadeseh; Habib, Asadollah.
+Institution
+ Habib, Ashkan. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
+ Molayemat, Mohadeseh. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
+ Habib, Asadollah. Adjunct Professor, Department of Endocrinology, Kazeroon Azad University of Medical Sciences, First Floor, Zafar Building, Zand St., PO Box: 71384-37984, Shiraz, Iran.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases/et [Etiology]
+ Child
+ Child, Preschool
+ Cross-Sectional Studies
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/co [Complications]
+ *Dyslipidemias/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ Hyperlipidemias/bl [Blood]
+ Hyperlipidemias/co [Complications]
+ *Hyperlipidemias/ep [Epidemiology]
+ Iran/ep [Epidemiology]
+ *Lipids/bl [Blood]
+ Male
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ Overweight/bl [Blood]
+ Overweight/co [Complications]
+ *Overweight/ep [Epidemiology]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ BMI
+ BMI Z-score
+ Iran
+ children
+ dyslipidemia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Heart disease has been the leading cause of death for decades in the US population. Dyslipidemia is the most important risk factor for cardiovascular disease (CVD), and it often starts during childhood. Methods This cross-sectional study was performed in a growth assessment clinic in the city of Shiraz to determine the relation between body mass index (BMI) and dyslipidemia among children and teenagers aged 2-18 years. Nine hundred and eighty-nine children including 422 boys and 567 girls were selected. Results Adjusted for age and gender, total cholesterol (TC) (r = 0.172, p = 0.000), low-density lipoprotein cholesterol (LDL-c) (r = 0.176, p = 0.000), non-high-density lipoprotein cholesterol (non-HDL-c) (r = 0.227, p = 0.000) and triglycerides (TG) (r = 0.253, p = 0.000) showed a significant positive correlation with BMI Z-score, and HDL-c showed a significant negative correlation with BMI Z-score (r = -0.131, p = 0.000). Adjusted for age and gender, overweight and obese children were 1.882 times more likely to have high TC levels (p = 0.009), 2.236 times more likely to have high non-HDL-c levels (p = 0.000) and 3.176 times more likely to have high TG levels (p = 0.000) in comparison with children who had a healthy weight. Obese children had the highest percentage of isolated TG dyslipidemia (23.1%) and underweight children had the highest percentage of isolated HDL dyslipidemia (15.6%). Conclusions There is a strong link between atherosclerotic cardiovascular disease (ASCVD) and the level of blood lipids and between blood lipids and BMI Z-score. The first step in preventing ASCVD is the reduction of blood lipids, preventing weight gain and loss of extra weight.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fjpem-2019-0002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Habib&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Association+of+lipid+profile+and+BMI+Z-score+in+southern+Iranian+children+and+adolescents.&volume=32&issue=8&spage=827&epage=835&date=2019&doi=10.1515%2Fjpem-2019-0002&pmid=31219798&sid=OVID:medline
+
+<1624>
+Unique Identifier
+ 31219502
+Title
+ Comments on: Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome. Relationships to insulin resistance and obesity.
+Source
+ Saudi Medical Journal. 40(6):630-631, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Saeed A
+Authors Full Name
+ Al-Saeed, Abdulghani.
+Institution
+ Al-Saeed, Abdulghani. Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail. ahalsaeed@psmmc.med.sa.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Humans
+ *Insulin Resistance
+ *Metabolic Syndrome/dg [Diagnostic Imaging]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/ge [Genetics]
+ *Nucleobindins/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/et [Etiology]
+Abstract
+ [No Abstract Available].
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (NUCB2 protein, human). 0 (Nucleobindins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.15537%2fsmj.2019.6.24181
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Saeed&issn=0379-5284&title=Saudi+Medical+Journal&atitle=Comments+on%3A+Serum+nesfatin-1+and+galanin+concentrations+in+the+adult+with+metabolic+syndrome.+Relationships+to+insulin+resistance+and+obesity.&volume=40&issue=6&spage=630&epage=631&date=2019&doi=10.15537%2Fsmj.2019.6.24181&pmid=31219502&sid=OVID:medline
+
+<1625>
+Unique Identifier
+ 31216161
+Title
+ High Blood pressure and other cardiovascular risk factors in students of the national university of Asuncion-Paraguay. [Spanish]
+Original Title
+ [Presion arterial elevada y otros factores de riesgo cardiovascular en estudiantes de la Universidad Nacional de Asuncion-Paraguay.]
+Source
+ Revista de la Facultad de Ciencias Medicas de Cordoba. 76(2):79-85, 2019 06 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ortiz Galeano I; Farina-Lopez RM; Insaurralde Rodriguez SA; Chirico Achinelli CE
+Authors Full Name
+ Ortiz Galeano, Ignacio; Farina-Lopez, Rosa Margarita; Insaurralde Rodriguez, Santiago Amado; Chirico Achinelli, Cesar Erasmo.
+Institution
+ Ortiz Galeano, Ignacio. Facultad de Ciencias Medicas. Universidad Nacional de Asuncion.. ignacioortizgaleano@yahoo.es.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Alcohol Drinking/ae [Adverse Effects]
+ Biomarkers/bl [Blood]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ Hypertension/et [Etiology]
+ Male
+ *Obesity/co [Complications]
+ Paraguay/ep [Epidemiology]
+ Prevalence
+ Risk Factors
+ *Smoking/ae [Adverse Effects]
+ Students, Health Occupations/sn [Statistics & Numerical Data]
+ Young Adult
+Keyword Heading
+ young adult
+ hypertension
+ overweight
+ obesity
+ dyslipidemias
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: High blood pressure is a category of blood pressure, poorly studied in young adults and is associated with other cardiovascular risk factors. Objective: To estimate the prevalence of high blood pressure and other cardiovascular risk factors in university students of the National University of Asuncion-Paraguay.
+
+ Methods: Cross-sectional study in first-year university students of careers related to health at the National University of Asuncion. High blood pressure was considered at a systolic blood pressure of 120-129 mmHg and / or diastolic blood pressure of ?80 mmHg. The anthropometric, lipid and metabolic variables were measured and the smoking and alcohol habit were determined.
+
+ Results: 284 university students were included in the analysis (mean age [+/- SD] 19.4 +/- 2.1 years, 73.2% were women). The overall prevalence of high blood pressure was 25.5%; (95% CI: 20.5-30.5%) (Men 40%, Women 29%). High blood pressure was associated with increased abdominal circumference (OR: 1.031, 95% CI: 1.005-1.058, p = 0.024); low HDL-C (OR: 1.355, 95% CI 1.054-1.743, p = 0.018); obesity, OR: 2,124; 95% CI: 1.334-3.941; p = 0.007) and DM2 (OR: 4.431, 95% CI: 3,642-7,963, p = <0.001). The prevalence of other cardiovascular risk factors more frequent were alcohol consumption, overweight and obesity. More than 70% of college students have one or more cardiovascular risk factors.
+
+ Conclusions: high prevalence of high blood pressure and is associated with other cardiovascular risk factors.
+Other Abstract
+ Publisher
+ Introduccion: La presion arterial elevada es una categoria de presion arterial, poco estudiado en adultos jovenes y esta asociado a otros factores de riesgo cardiovascular.
+ Objetivos: Estimar la prevalencia de presion arterial elevada y otros factores de riesgo cardiovascular en universitarios de la Universidad Nacional de Asuncion-Paraguay.
+ Material y metodos: Estudio transversal en universitarios de primer curso de las carreras relacionadas a la salud de la Universidad Nacional de Asuncion. Se considero presion arterial elevada a una presion arterial sistolica de 120-129 mmHg y/o presion arterial diastolica de ?80 mmHg. Se midieron las variables antropometricas, lipidicas, metabolicas y se determino el habito tabaquico y de alcohol.
+ Resultados: Se incluyeron en el analisis 284 universitarios (edad media [+/-DE] 19,4 +/-2,1 anos; 73,2% fueron mujeres). La prevalencia global de la presion arterial elevada fue del 25,5%; (IC del 95%: 20,5-30,5%) (hombres 40%; mujeres 29%). La presion arterial elevada se asocio con la circunferencia abdominal aumentada (OR: 1,031; IC del 95%: 1,005-1,058; p= 0,024); el c-HDL baja (OR: 1,355; IC del 95%: 1,054-1,743; p=0,018); la obesidad, OR: 2,124; IC del 95%: 1,334-3,941; p=0,007) y la DM2 (OR: 4,431; IC del 95%: 3,642-7,963; p=<0,001). La prevalencia de otros factores de riesgo cardiovascular mas frecuente fueron el consumo de alcohol, el sobrepeso y la obesidad. Mas del 70% de los universitarios tienen uno o mas factor de riesgo cardiovascular.
+ Conclusiones: alta prevalencia de la presion arterial elevada y esta asociado con otros factores de riesgo cardiovascular.
+ Language: Spanish
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.31053%2f1853.0605.v76.n2.23152
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ortiz+Galeano&issn=0014-6722&title=Revista+de+la+Facultad+de+Ciencias+Medicas+de+Cordoba&atitle=%5BPresion+arterial+elevada+y+otros+factores+de+riesgo+cardiovascular+en+estudiantes+de+la+Universidad+Nacional+de+Asuncion-Paraguay.%5D&volume=76&issue=2&spage=79&epage=85&date=2019&doi=10.31053%2F1853.0605.v76.n2.23152&pmid=31216161&sid=OVID:medline
+
+<1626>
+Unique Identifier
+ 31214196
+Title
+ Retained NK Cell Phenotype and Functionality in Non-alcoholic Fatty Liver Disease.
+Source
+ Frontiers in Immunology. 10:1255, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stiglund N; Strand K; Cornillet M; Stal P; Thorell A; Zimmer CL; Naslund E; Karlgren S; Nilsson H; Mellgren G; Ferno J; Hagstrom H; Bjorkstrom NK
+Authors Full Name
+ Stiglund, Natalie; Strand, Kristina; Cornillet, Martin; Stal, Per; Thorell, Anders; Zimmer, Christine L; Naslund, Erik; Karlgren, Silja; Nilsson, Henrik; Mellgren, Gunnar; Ferno, Johan; Hagstrom, Hannes; Bjorkstrom, Niklas K.
+Institution
+ Stiglund, Natalie. Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
+ Strand, Kristina. Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.
+ Strand, Kristina. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
+ Cornillet, Martin. Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
+ Stal, Per. Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden.
+ Stal, Per. Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
+ Thorell, Anders. Department of Surgery, Ersta Hospital, Stockholm, Sweden.
+ Thorell, Anders. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Solna, Sweden.
+ Zimmer, Christine L. Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
+ Naslund, Erik. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Solna, Sweden.
+ Karlgren, Silja. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Solna, Sweden.
+ Nilsson, Henrik. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Solna, Sweden.
+ Mellgren, Gunnar. Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.
+ Mellgren, Gunnar. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
+ Ferno, Johan. Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.
+ Ferno, Johan. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
+ Hagstrom, Hannes. Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden.
+ Hagstrom, Hannes. Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
+ Bjorkstrom, Niklas K. Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
+MeSH Subject Headings
+ Adipose Tissue/im [Immunology]
+ Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Adult
+ Aged
+ Biomarkers
+ Disease Susceptibility
+ Female
+ Humans
+ Immunophenotyping
+ *Killer Cells, Natural/im [Immunology]
+ *Killer Cells, Natural/me [Metabolism]
+ Liver/im [Immunology]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Male
+ Middle Aged
+ NK Cell Lectin-Like Receptor Subfamily K/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Organ Specificity/im [Immunology]
+Keyword Heading
+ NAFLD
+ adipose tissue immunology
+ liver immunology
+ natural killer cells
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Non-alcoholic fatty liver disease (NAFLD), and the progressive stage non-alcoholic steatohepatitis (NASH), is the predominant cause of chronic liver disease globally. As part of the complex pathogenesis, natural killer (NK) cells have been implicated in the development of liver inflammation in experimental murine models of NASH. However, there is a lack of knowledge on how NK cells are affected in humans with this disease. Here, we explored the presence of disease-specific changes within circulating and tissue-resident NK cell populations, as well as within other major immune cell subsets, in patients with liver biopsy-confirmed NAFLD. Using 18-color-flow cytometry, substantial changes were observed in certain myeloid populations in patients as compared to controls. NK cell numbers, on the other hand, were not altered. Furthermore, only minor differences in expression of activating and inhibitory NK cell receptors were noted, with the exception of an increased expression of NKG2D on NK cells from patients with NASH. NK cell differentiation remained constant, and NK cells from these patients retain their ability to respond adequately upon stimulation. Instead, considerable alterations were observed between liver, adipose tissue, and peripheral blood NK cells, independently of disease status. Taken together, these results increase our understanding of the importance of the local microenvironment in shaping the NK cell compartment and stress the need for further studies exploring how NASH affects intrahepatic NK cells in humans.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (KLRK1 protein, human). 0 (NK Cell Lectin-Like Receptor Subfamily K).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3389%2ffimmu.2019.01255
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stiglund&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Retained+NK+Cell+Phenotype+and+Functionality+in+Non-alcoholic+Fatty+Liver+Disease.&volume=10&issue=&spage=1255&epage=&date=2019&doi=10.3389%2Ffimmu.2019.01255&pmid=31214196&sid=OVID:medline
+
+<1627>
+Unique Identifier
+ 31212761
+Title
+ Adipose Tissue, Obesity and Adiponectin: Role in Endocrine Cancer Risk. [Review]
+Source
+ International Journal of Molecular Sciences. 20(12), 2019 Jun 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tumminia A; Vinciguerra F; Parisi M; Graziano M; Sciacca L; Baratta R; Frittitta L
+Author NameID
+ Sciacca, Laura; ORCID: https://orcid.org/0000-0002-3258-7200
+ Frittitta, Lucia; ORCID: https://orcid.org/0000-0002-7941-5828
+Authors Full Name
+ Tumminia, Andrea; Vinciguerra, Federica; Parisi, Miriam; Graziano, Marco; Sciacca, Laura; Baratta, Roberto; Frittitta, Lucia.
+Institution
+ Tumminia, Andrea. Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi Hospital, Via Palermo 636, 95122 Catania, Italy. andreatumminia@libero.it.
+ Vinciguerra, Federica. Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi Hospital, Via Palermo 636, 95122 Catania, Italy. vinciguerrafederica@gmail.com.
+ Parisi, Miriam. Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi Hospital, Via Palermo 636, 95122 Catania, Italy. mrmparisi@gmail.com.
+ Graziano, Marco. Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi Hospital, Via Palermo 636, 95122 Catania, Italy. graziano.marco91@gmail.com.
+ Sciacca, Laura. Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi Hospital, Via Palermo 636, 95122 Catania, Italy. lsciacca@unict.it.
+ Baratta, Roberto. Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi Hospital, Via Palermo 636, 95122 Catania, Italy. rob.baratta@gmail.com.
+ Frittitta, Lucia. Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi Hospital, Via Palermo 636, 95122 Catania, Italy. lfritti@unict.it.
+MeSH Subject Headings
+ Adiponectin/ch [Chemistry]
+ Adiponectin/ge [Genetics]
+ *Adiponectin/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Cell Transformation, Neoplastic/ge [Genetics]
+ Cell Transformation, Neoplastic/me [Metabolism]
+ Endocrine Gland Neoplasms/di [Diagnosis]
+ *Endocrine Gland Neoplasms/et [Etiology]
+ Endocrine Gland Neoplasms/me [Metabolism]
+ Endocrine Gland Neoplasms/th [Therapy]
+ Humans
+ Insulin/me [Metabolism]
+ Models, Biological
+ Neoplasm Metastasis
+ *Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Paracrine Communication
+ Protein Binding
+ Receptors, Adiponectin/ge [Genetics]
+ Receptors, Adiponectin/me [Metabolism]
+ Risk
+ Risk Assessment
+ Structure-Activity Relationship
+Keyword Heading
+ adiponectin
+ adipose tissue
+ endocrine cancer
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Adipose tissue has been recognized as a complex organ with endocrine and metabolic roles. The excess of fat mass, as occurs during overweight and obesity states, alters the regulation of adipose tissue, contributing to the development of obesity-related disorders. In this regard, many epidemiological studies shown an association between obesity and numerous types of malignancies, comprising those linked to the endocrine system (e.g., breast, endometrial, ovarian, thyroid and prostate cancers). Multiple factors may contribute to this phenomenon, such as hyperinsulinemia, dyslipidemia, oxidative stress, inflammation, abnormal adipokines secretion and metabolism. Among adipokines, growing interest has been placed in recent years on adiponectin (APN) and on its role in carcinogenesis. APN is secreted by adipose tissue and exerts both anti-inflammatory and anti-proliferative actions. It has been demonstrated that APN is drastically decreased in obese individuals and that it can play a crucial role in tumor growth. Although literature data on the impact of APN on carcinogenesis are sometimes conflicting, the most accredited hypothesis is that it has a protective action, preventing cancer development and progression. The aim of the present review is to summarize the currently available evidence on the involvement of APN and its signaling in the etiology of cancer, focusing on endocrine malignancies.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Insulin). 0 (Receptors, Adiponectin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20122863
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tumminia&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Adipose+Tissue%2C+Obesity+and+Adiponectin%3A+Role+in+Endocrine+Cancer+Risk.&volume=20&issue=12&spage=2863&epage=&date=2019&doi=10.3390%2Fijms20122863&pmid=31212761&sid=OVID:medline
+
+<1628>
+Unique Identifier
+ 31211621
+Title
+ Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-alpha-mediated fatty acid oxidation.
+Source
+ American Journal of Physiology - Endocrinology & Metabolism. 317(3):E436-E445, 2019 09 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu X; Zheng H; Yang R; Luan X; Zhang L; Jin Q; Jin Y; Xue J
+Authors Full Name
+ Wu, Xiaojie; Zheng, Hongze; Yang, Rui; Luan, Xiying; Zhang, Lingyun; Jin, Qingsong; Jin, Yongjun; Xue, Jiangnan.
+Institution
+ Wu, Xiaojie. Department of Immunology, Binzhou Medical University, Yantai, China.
+ Wu, Xiaojie. Central Laboratory, Binzhou People's Hospital, Binzhou, China.
+ Zheng, Hongze. Central Laboratory, Binzhou People's Hospital, Binzhou, China.
+ Yang, Rui. Department of Immunology, Binzhou Medical University, Yantai, China.
+ Luan, Xiying. Department of Immunology, Binzhou Medical University, Yantai, China.
+ Zhang, Lingyun. Department of Endocrinology, Yantai Affiliated Hospital, Binzhou Medical University, Yantai, China.
+ Jin, Qingsong. Department of Endocrinology, Yantai Affiliated Hospital, Binzhou Medical University, Yantai, China.
+ Jin, Yongjun. Department of Endocrinology, Yantai Affiliated Hospital, Binzhou Medical University, Yantai, China.
+ Xue, Jiangnan. Department of Immunology, Binzhou Medical University, Yantai, China.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Diabetes Mellitus, Experimental/me [Metabolism]
+ Diabetes Mellitus, Experimental/th [Therapy]
+ Diet, High-Fat
+ *Fatty Acids/me [Metabolism]
+ Gene Knockdown Techniques
+ Genetic Therapy
+ Hepatocytes/me [Metabolism]
+ Lipogenesis/ge [Genetics]
+ Liver/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Non-alcoholic Fatty Liver Disease/ge [Genetics]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/th [Therapy]
+ Obesity/me [Metabolism]
+ Oxidation-Reduction
+ *PPAR alpha/bi [Biosynthesis]
+ PPAR alpha/ge [Genetics]
+ *Trefoil Factor-3/ge [Genetics]
+Keyword Heading
+ fatty acid oxidation
+ lipogenesis
+ mouse trefoil factor 3
+ nonalcoholic fatty liver disease
+ peroxisome proliferator-activated receptor-alpha
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Hepatic trefoil factor 3 (Tff3) was identified as a potential protein for the treatment of diabetes, yet the effect of Tff3 on nonalcoholic fatty liver disease (NAFLD) has never been explored. Here, we found that the expression of hepatic Tff3 was significantly decreased in NAFLD mice models, suggesting that Tff3 was a potential marker gene for NAFLD. Restoring the expression of Tff3 in the liver of NAFLD mice, including diabetic (db), obese (ob/ob), and diet-induced obese mice, with adenovirus-mediated Tff3 (Ad-Tff3) apparently attenuates the fatty liver phenotype. In contrast, adenovirus-mediated knockdown of Tff3 (Ad-shTff3) in C57BL/6J mice results in an obvious fatty liver phenotype. Furthermore, our molecular experiments indicated that hepatic Tff3 could alleviate hepatic steatosis via upregulating the expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) directly, thereby enhancing the fatty acid oxidation process in the liver. Notably, we found that Tff3 attenuates the fatty liver phenotype independent of modulation of lipogenesis and improves the capacity of anti-inflammation. Overall, our results suggested that hepatic Tff3 could be effectively used as a potential therapy target for the treatment of NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids). 0 (PPAR alpha). 0 (Ppara protein, mouse). 0 (Tff3 protein, mouse). 0 (Trefoil Factor-3).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1152%2fajpendo.00454.2018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=0193-1849&title=American+Journal+of+Physiology+-+Endocrinology+%26+Metabolism&atitle=Mouse+trefoil+factor+3+ameliorated+high-fat-diet-induced+hepatic+steatosis+via+increasing+peroxisome+proliferator-activated+receptor-alpha-mediated+fatty+acid+oxidation.&volume=317&issue=3&spage=E436&epage=E445&date=2019&doi=10.1152%2Fajpendo.00454.2018&pmid=31211621&sid=OVID:medline
+
+<1629>
+Unique Identifier
+ 31209632
+Title
+ Obesity-Related Genetic Determinants of Heart Failure Prognosis.
+Source
+ Cardiovascular Drugs & Therapy. 33(4):415-424, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Agra RM; Gago-Dominguez M; Paradela-Dobarro B; Torres-Espanol M; Alvarez L; Fernandez-Trasancos A; Varela-Roman A; Calaza M; Eiras S; Alvarez E; Carracedo A; Gonzalez-Juanatey JR
+Author NameID
+ Alvarez, E; ORCID: https://orcid.org/0000-0002-2381-8425
+Authors Full Name
+ Agra, R M; Gago-Dominguez, M; Paradela-Dobarro, B; Torres-Espanol, M; Alvarez, L; Fernandez-Trasancos, A; Varela-Roman, A; Calaza, M; Eiras, S; Alvarez, E; Carracedo, A; Gonzalez-Juanatey, J R.
+Institution
+ Agra, R M. Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Servicio de Cardiologia y Unidad de Hemodinamica, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, Santiago de Compostela, 15706, A Coruna, Spain.
+ Agra, R M. CIBERCV, Madrid, Spain.
+ Gago-Dominguez, M. Fundacion Publica Galega de Medicina Xenomica, SERGAS, Santiago de Compostela, Spain.
+ Paradela-Dobarro, B. Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Servicio de Cardiologia y Unidad de Hemodinamica, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, Santiago de Compostela, 15706, A Coruna, Spain.
+ Paradela-Dobarro, B. CIBERCV, Madrid, Spain.
+ Torres-Espanol, M. Grupo de Medicina Xenomica, CeGen-PRB2, Instituto de Investigacion Sanitaria de Santiago, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
+ Alvarez, L. Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Servicio de Cardiologia y Unidad de Hemodinamica, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, Santiago de Compostela, 15706, A Coruna, Spain.
+ Alvarez, L. CIBERCV, Madrid, Spain.
+ Fernandez-Trasancos, A. Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Servicio de Cardiologia y Unidad de Hemodinamica, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, Santiago de Compostela, 15706, A Coruna, Spain.
+ Fernandez-Trasancos, A. CIBERCV, Madrid, Spain.
+ Varela-Roman, A. Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Servicio de Cardiologia y Unidad de Hemodinamica, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, Santiago de Compostela, 15706, A Coruna, Spain.
+ Varela-Roman, A. CIBERCV, Madrid, Spain.
+ Calaza, M. Centro de Investigacion en Medicina Molecular y Enfermedades Cronicas, CIMUS, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
+ Eiras, S. Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Servicio de Cardiologia y Unidad de Hemodinamica, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, Santiago de Compostela, 15706, A Coruna, Spain.
+ Eiras, S. CIBERCV, Madrid, Spain.
+ Alvarez, E. Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Servicio de Cardiologia y Unidad de Hemodinamica, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, Santiago de Compostela, 15706, A Coruna, Spain. ezequiel.alvarez.castro@gmail.com.
+ Alvarez, E. CIBERCV, Madrid, Spain. ezequiel.alvarez.castro@gmail.com.
+ Carracedo, A. Fundacion Publica Galega de Medicina Xenomica, SERGAS, Santiago de Compostela, Spain.
+ Gonzalez-Juanatey, J R. Laboratorio no. 6. Edif. Consultas externas (planta -2), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Servicio de Cardiologia y Unidad de Hemodinamica, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, Santiago de Compostela, 15706, A Coruna, Spain.
+ Gonzalez-Juanatey, J R. CIBERCV, Madrid, Spain.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Disease Progression
+ Female
+ Genetic Association Studies
+ Genetic Predisposition to Disease
+ *Heart Failure/ge [Genetics]
+ Heart Failure/mo [Mortality]
+ Heart Failure/pp [Physiopathology]
+ Humans
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/ge [Genetics]
+ Obesity/mo [Mortality]
+ Obesity/pp [Physiopathology]
+ Phenotype
+ *Polymorphism, Single Nucleotide
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Time Factors
+Keyword Heading
+ Cardiometabolic disorders
+ Genomic cardiovascular predictors
+ Heart failure prognosis
+ Single nucleotide polymorphisms
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Recent advances in genomics offer a smart option for predicting future risk of disease and prognosis. The objective of this study was to examine the prognostic value in heart failure (HF) patients, of a series of single nucleotide polymorphisms (SNPs).
+
+ METHODS: A selection of 192 SNPs found to be related with obesity, body mass index, circulating lipids or cardiovascular diseases were genotyped in 191 patients with HF. Anthropometrical and clinical variables were collected for each patient, and death and readmission by HF were registered as the primary endpoint.
+
+ RESULTS: A total of 53 events were registered during a follow-up period of 438 (263-1077) days (median (IQR)). Eight SNPs strongly related to obesity and HF prognosis were selected as possible prognostic variables. From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018). Combined scores of the genomic variants were highly predictive of poor prognosis.
+
+ CONCLUSIONS: SNPs rs10189761 and rs737337 were identified, for the first time, as independent predictors of major clinical outcomes in patients with HF. The data suggests an additive predictive value of these SNPs for a HF prognosis. In particular for obese patients, SNPs rs10423928, rs1800437, rs737337 and rs9351814 were related with a bad prognosis. Combined scores weighting the risk of each genomic variant could effect interesting new tools to stratify the prognostic risk of HF patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs10557-019-06888-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Agra&issn=0920-3206&title=Cardiovascular+Drugs+%26+Therapy&atitle=Obesity-Related+Genetic+Determinants+of+Heart+Failure+Prognosis.&volume=33&issue=4&spage=415&epage=424&date=2019&doi=10.1007%2Fs10557-019-06888-8&pmid=31209632&sid=OVID:medline
+
+<1630>
+Unique Identifier
+ 31207658
+Title
+ Neuroendocrine Control, Inflammation, and Psychological Aspects After Interdisciplinary Therapy in Obese Women.
+Source
+ Hormone & Metabolic Research. 51(6):375-380, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Moraes ADS; Cipullo MAT; Poli VFS; Rebelo RA; Ribeiro EB; Oyama LM; Silva SGA; Damaso AR; Padovani RDC; Caranti DA
+Authors Full Name
+ Moraes, Amanda Dos Santos; Cipullo, Marcos Alberto Taddeo; Poli, Vanessa Fadanelli Schoenardie; Rebelo, Renata Astride; Ribeiro, Eliane Beraldi; Oyama, Lila Missae; Silva, Stephan Garcia Andrade; Damaso, Ana Raimunda; Padovani, Ricardo da Costa; Caranti, Danielle Arisa.
+Institution
+ Moraes, Amanda Dos Santos. Post Graduate Program of Interdisciplinary Health Sciences, Federal University of Sao Paulo -UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Moraes, Amanda Dos Santos. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Cipullo, Marcos Alberto Taddeo. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Cipullo, Marcos Alberto Taddeo. Health, Education and Society Department, Federal University of Sao Paulo - UNIFESP -Santos, Sao Paulo, SP, Brazil.
+ Poli, Vanessa Fadanelli Schoenardie. Post Graduate Program of Interdisciplinary Health Sciences, Federal University of Sao Paulo -UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Poli, Vanessa Fadanelli Schoenardie. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Rebelo, Renata Astride. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Ribeiro, Eliane Beraldi. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Ribeiro, Eliane Beraldi. Post Graduate Program of Food, Nutrition, Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Oyama, Lila Missae. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Oyama, Lila Missae. Post Graduate Program of Food, Nutrition, Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Silva, Stephan Garcia Andrade. Post Graduate Program of Interdisciplinary Health Sciences, Federal University of Sao Paulo -UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Silva, Stephan Garcia Andrade. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Damaso, Ana Raimunda. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Damaso, Ana Raimunda. Post Graduate Program of Food, Nutrition, Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Padovani, Ricardo da Costa. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Padovani, Ricardo da Costa. Health, Education and Society Department, Federal University of Sao Paulo - UNIFESP -Santos, Sao Paulo, SP, Brazil.
+ Caranti, Danielle Arisa. Post Graduate Program of Interdisciplinary Health Sciences, Federal University of Sao Paulo -UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Caranti, Danielle Arisa. Obesity Study Group (GEO), Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Caranti, Danielle Arisa. Post Graduate Program of Food, Nutrition, Federal University of Sao Paulo - UNIFESP - Santos, Sao Paulo, SP, Brazil.
+ Caranti, Danielle Arisa. Biosciences Department, Federal University of Sao Paulo - UNIFESP -Santos, Sao Paulo, SP, Brazil.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Body Composition
+ Body Mass Index
+ *Diet Therapy
+ *Exercise Therapy
+ Female
+ Healthy Lifestyle
+ Humans
+ *Inflammation/pc [Prevention & Control]
+ Leptin
+ Middle Aged
+ *Obesity/px [Psychology]
+ *Obesity/th [Therapy]
+ Patient Care Team
+ *Psychotherapy
+ Weight Loss
+Abstract
+ Obesity is a chronic and multifactorial disease promoted by positive energy balance. The objective was to evaluate the effects of interdisciplinary therapy in the neuroendocrine control of food intake, inflammatory markers, and psychological aspects in obese women. Forty-seven obese women (43.32+/-5.82 years, 34.86+/-3.08 kg/m2), aged 30-50 years, participated in an interdisciplinary lifestyle change therapy, consisting of nutritional counseling, physical exercises, and psychological therapy for 36 weeks. After the long-term therapy, there was a decrease in body weight (DELTA -5.36 kg), BMI (DELTA -2.01 kg/m2), abdominal (DELTA -9.09 cm), hip (DELTA -5.03 cm), and thigh (DELTA -5.07 cm) perimeters. There was also a significant improvement in body composition, with an increase in fat-free mass (DELTA 1.60%) and reduction of body fat (DELTA -3.74 kg). The therapy proposed also provided an improvement in depression scores (DELTA -6.63), anxiety (DELTA -4.07), body image (DELTA -25.25), and binge eating (DELTA -5.25). There was a significant reduction in serum levels of leptin (DELTA -15.62 ng/ml). The interdisciplinary therapy was able to provide both, physical and psychological benefits in energy balance, which enables the use of this model as a feasible clinical strategy for the treatment of obesity. Copyright © Georg Thieme Verlag KG Stuttgart . New York.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1055%2fa-0896-8853
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Moraes&issn=0018-5043&title=Hormone+%26+Metabolic+Research&atitle=Neuroendocrine+Control%2C+Inflammation%2C+and+Psychological+Aspects+After+Interdisciplinary+Therapy+in+Obese+Women.&volume=51&issue=6&spage=375&epage=380&date=2019&doi=10.1055%2Fa-0896-8853&pmid=31207658&sid=OVID:medline
+
+<1631>
+Unique Identifier
+ 31207126
+Title
+ Obesity in older adults: Effect of degree of weight loss on cardiovascular markers and medications.
+Source
+ Clinical Obesity. 9(4):e12316, 2019 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Haywood CJ; Prendergast LA; Lim R; Lappas M; Lim WK; Proietto J
+Author NameID
+ Haywood, Cilla J; ORCID: https://orcid.org/0000-0002-8127-7014
+Authors Full Name
+ Haywood, Cilla J; Prendergast, Luke A; Lim, Ratana; Lappas, Martha; Lim, Wen Kwang; Proietto, Joseph.
+Institution
+ Haywood, Cilla J. Department of Medicine (Austin Health), University of Melbourne, Melbourne, Victoria, Australia.
+ Haywood, Cilla J. Department of Aged Care, Austin Health, Melbourne, Victoria, Australia.
+ Haywood, Cilla J. Department of Endocrinology, Austin Health, Melbourne, Victoria, Australia.
+ Prendergast, Luke A. Mathematics and Statistics, LaTrobe University, Melbourne, Victoria, Australia.
+ Lim, Ratana. Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Melbourne, Victoria, Australia.
+ Lappas, Martha. Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Melbourne, Victoria, Australia.
+ Lim, Wen Kwang. Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Victoria, Australia.
+ Lim, Wen Kwang. Department of Aged Care, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
+ Proietto, Joseph. Department of Medicine (Austin Health), University of Melbourne, Melbourne, Victoria, Australia.
+ Proietto, Joseph. Department of Endocrinology, Austin Health, Melbourne, Victoria, Australia.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Antihypertensive Agents/an [Analysis]
+ Antihypertensive Agents/tu [Therapeutic Use]
+ *Biomarkers/me [Metabolism]
+ Blood Pressure/de [Drug Effects]
+ Body Mass Index
+ *Cardiovascular Diseases/dt [Drug Therapy]
+ Cardiovascular Diseases/me [Metabolism]
+ Cardiovascular Diseases/pp [Physiopathology]
+ Cholesterol, HDL/me [Metabolism]
+ *Diabetes Mellitus/dt [Drug Therapy]
+ Diabetes Mellitus/me [Metabolism]
+ Diabetes Mellitus/pp [Physiopathology]
+ Diet, Reducing
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Hypoglycemic Agents/an [Analysis]
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Male
+ Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Triglycerides/me [Metabolism]
+ Weight Loss
+Keyword Heading
+ diabetes
+ hypertension
+ obesity
+ older adults
+ reducing diet
+ very-low-calorie diet
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity worsens the age-related tendency towards cardiovascular disease and diabetes. Older adults are vulnerable to medication adverse effects. Intentional weight loss in older adults with obesity has been shown to improve cardiovascular and glycaemic markers. The effect of rapid weight loss induced by very-low-calorie diets (VLCDs) on these markers has not been evaluated in this group. In this 12-week study, participants were randomized to one of healthy eating, hypocaloric diet or VLCD, all combined with three times weekly exercise (Ex/HE, Ex/Diet, Ex/VLCD, respectively). The effects of these interventions on weight, blood pressure, lipids, glucose and HbA1c , inflammatory markers and cardiovascular and diabetes medication changes were measured. Weight loss was 3.7%, 5.1% and 11.1% in Ex/HE, Ex/Diet and Ex/VLCD, respectively. There were significant improvements in HbA1c in all groups, but by the greatest degree in Ex/VLCD (0.18 +/- 0.07%, 0.18 +/- 0.06% and 0.59 +/- 0.13%, respectively). Similar patterns were seen in total cholesterol (0.13 +/- 0.15, 0.21 +/- 0.11 and 0.53 +/- 0.13 mmol/L, respectively, P = .047), triglycerides (0.35 +/- 0.13, 0.20 +/- 0.10 and 0.51 +/- 0.09 mmol/L, respectively, P = .011) and systolic blood pressure (9 +/- 2, 2 +/- 3 and 14 +/- 3 mmHg respectively, P = .025). There were no between-group differences in fasting glucose, high-density lipoprotein (HDL) cholesterol, LDL-C and inflammatory markers. Reductions in anti-hypertensive or diabetes medication were made in 4/29, 7/36 and 16/37 participants in Ex/HE, Ex/Diet and Ex/VLCD, respectively (P = .017). Significant weight loss achieved with a VLCD gave rise to improvements in multiple cardiovascular risk markers, despite reduction in medication. Weight loss is an under-utilized method of cardiovascular risk management in this group. Copyright © 2019 World Obesity Federation.
+Registry Number/Name of Substance
+ 0 (Antihypertensive Agents). 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (Triglycerides).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fcob.12316
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Haywood&issn=1758-8103&title=Clinical+Obesity&atitle=Obesity+in+older+adults%3A+Effect+of+degree+of+weight+loss+on+cardiovascular+markers+and+medications.&volume=9&issue=4&spage=e12316&epage=&date=2019&doi=10.1111%2Fcob.12316&pmid=31207126&sid=OVID:medline
+
+<1632>
+Unique Identifier
+ 31204630
+Title
+ Profiles of gene expression in maternal blood predict offspring birth weight in normal pregnancy.
+Source
+ Journal of Developmental Origins of Health and Disease. 10(6):676-682, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ McDade TW; Kuzawa CW; Borja J; Arevalo JMG; Miller G; Cole SW
+Authors Full Name
+ McDade, Thomas W; Kuzawa, Chris W; Borja, Judith; Arevalo, Jesusa M G; Miller, Greg; Cole, Steve W.
+Institution
+ McDade, Thomas W. Department of Anthropology, Northwestern University, Evanston, IL, USA.
+ McDade, Thomas W. Institute for Policy Research, Northwestern University, Evanston, IL, USA.
+ McDade, Thomas W. Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.
+ Kuzawa, Chris W. Department of Anthropology, Northwestern University, Evanston, IL, USA.
+ Kuzawa, Chris W. Institute for Policy Research, Northwestern University, Evanston, IL, USA.
+ Borja, Judith. USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.
+ Borja, Judith. Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines.
+ Arevalo, Jesusa M G. Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA.
+ Miller, Greg. Institute for Policy Research, Northwestern University, Evanston, IL, USA.
+ Miller, Greg. Department of Psychology, Northwestern University, Evanston, IL, USA.
+ Cole, Steve W. Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA.
+ Cole, Steve W. Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Birth Weight/ge [Genetics]
+ *Body Mass Index
+ Female
+ Follow-Up Studies
+ Gene Expression Profiling
+ Humans
+ Infant, Low Birth Weight/bl [Blood]
+ *Infant, Low Birth Weight/me [Metabolism]
+ Infant, Newborn
+ Longitudinal Studies
+ Male
+ Obesity/bl [Blood]
+ *Obesity/ge [Genetics]
+ Pregnancy
+ Pregnancy Complications/bl [Blood]
+ *Pregnancy Complications/ge [Genetics]
+ Prospective Studies
+ Young Adult
+Keyword Heading
+ Immune system
+ inflammation
+ intergenerational
+ newborn
+ prenatal environment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The association between lower birth weight and increased disease risk in adulthood has drawn attention to the physiological processes that shape the gestational environment. We implement genome-wide transcriptional profiling of maternal blood samples to identify subsets of genes and associated transcription control pathways that predict offspring birth weight. Female participants (N = 178, mean = 27.0 years) in a prospective observational birth cohort study were contacted between 2009 and 2014 to identify new pregnancies. An in-home interview was scheduled for early in the third trimester (mean = 30.3 weeks) to collect pregnancy-related information and a blood sample, and birth weight was measured shortly after delivery. Transcriptional activity in white blood cells was determined with a whole-genome gene expression direct hybridization assay. Fifty transcripts were differentially expressed in association with offspring birth weight, with 18 up-regulated in relation to lower birth weight, and 32 down-regulated. Examination of transcription control pathways identified increased activity of NF-kappaB, AP-1, EGR1, EGR4, and Gfi families, and reduced the activity of CEBP, in association with lower birth weight. Transcript origin analyses identified non-classical CD16+ monocytes, CD1c+ myeloid dendritic cells, and neutrophils as the primary cellular mediators of differential gene expression. These results point toward a systematic regulatory shift in maternal white blood cell activity in association with lower offspring birth weight, and they suggest that analyses of gene expression during gestation may provide insight into regulatory and cellular mechanisms that influence birth outcomes.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1017%2fS2040174419000175
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=McDade&issn=2040-1744&title=Journal+of+Developmental+Origins+of+Health+and+Disease&atitle=Profiles+of+gene+expression+in+maternal+blood+predict+offspring+birth+weight+in+normal+pregnancy.&volume=10&issue=6&spage=676&epage=682&date=2019&doi=10.1017%2FS2040174419000175&pmid=31204630&sid=OVID:medline
+
+<1633>
+Unique Identifier
+ 31192690
+Title
+ Green tea supplementation improves oxidative stress biomarkers and modulates IL-6 circulating levels in obese women.
+Original Title
+ La suplementacion con te verde mejora los biomarcadores del estres oxidativo y modula los niveles de IL-6 de la circulacion en mujeres obesas.
+Source
+ Nutricion Hospitalaria. 36(3):583-588, 2019 Jul 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Noronha NY; Pinhel MAS; Nicoletti CF; Quinhoneiro DCG; Pinhanelli VC; Oliveira BAP; Cortes-Oliveira C; Delfino HBP; Wolf LS; Frantz FG; Marchini JS; Nonino CB
+Authors Full Name
+ Noronha, Natalia Yumi; Pinhel, Marcela Augusta De Souza; Nicoletti, Carolina Ferreira; Quinhoneiro, Driele Cristina Gomes; Pinhanelli, Vitor Caressato; Oliveira, Bruno Affonso Parenti; Cortes-Oliveira, Cristiana; Delfino, Heitor Bernardes Pereira; Wolf, Leticia Santana; Frantz, Fabiani Gai; Marchini, Julio Sergio; Nonino, Carla Barbosa.
+Institution
+ Noronha, Natalia Yumi. Ribeirao Preto Medical School. University of Sao Paulo.
+ Pinhel, Marcela Augusta De Souza. Ribeirao Preto Medical School. University of Sao Paulo.
+ Nicoletti, Carolina Ferreira. Ribeirao Preto Medical School. University of Sao Paulo.
+ Quinhoneiro, Driele Cristina Gomes. Ribeirao Preto Medical School. University of Sao Paulo.
+ Pinhanelli, Vitor Caressato. Department of Internal Medicine. University of Sao Paulo.
+ Oliveira, Bruno Affonso Parenti. Ribeirao Preto Medical School. University of Sao Paulo.
+ Cortes-Oliveira, Cristiana. Ribeirao Preto Medical School. University of Sao Paulo.
+ Delfino, Heitor Bernardes Pereira. Ribeirao Preto Medical School. University of Sao Paulo.
+ Wolf, Leticia Santana. Ribeirao Preto Medical School. University of Sao Paulo.
+ Frantz, Fabiani Gai. Ribeirao Preto Medical School. University of Sao Paulo.
+ Marchini, Julio Sergio. Ribeirao Preto Medical School. University of Sao Paulo.
+ Nonino, Carla Barbosa. Ribeirao Preto Medical School. University of Sao Paulo.
+MeSH Subject Headings
+ Adult
+ Antioxidants/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cytokines/bl [Blood]
+ *Dietary Supplements
+ Female
+ Humans
+ *Interleukin-6/bl [Blood]
+ Malondialdehyde/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ *Oxidative Stress/de [Drug Effects]
+ *Tea
+ Young Adult
+Keyword Heading
+ Te verde. Catequina. Estres oxidativo. Inflamacion. TEAC Malondialdehido. IL-6. Obesidad.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Introduction: obesity is associated with high levels of oxidative stress (OS) and inflammation. There is a lot of evidence that some polyphenols, such as green tea, have a positive impact on the OS state and consecutively, on inflammation. Objectives: the purposes of this study were: a) evaluate OS biomarkers in both obese and normal weight women; and b) evaluate if green tea supplementation has an impact on OS and inflammatory cytokine biomarkers of obese women. Methods: we evaluated obese (body mass index [BMI] >= 40 kg/m2) and normal weight (BMI between 18.5 and 24.9 kg/m2) women. Blood samples were used to access malondialdehyde (MDA), trolox equivalent antioxidant capacity (TEAC) and inflammatory cytokines. We randomly chose obese patients (18 individuals) and then gave them green tea supplementation for eight weeks. Statistical analysis included the Shapiro-Wilk, Wilcoxon, independent and paired t tests; p < 0.05 were considered as significant. Results: we enrolled 42 obese (BMI: 48.2 +/- 9.3kg/m2) and 21 normal weight (BMI: 22.5 +/- 2 kg/m2) women with an average age of 36.2 +/- 9.1 years old. The serum levels of MDA were higher in obese (2.52 +/- 0.31 micromol/l) than in eutrophic women (2.13 +/- 0.26 micromol/l; p = 0.000). On the other hand, lower TEAC values were observed in the obese (0.75 +/- 0.06 mM/l) than in the eutrophic group (0.78 +/- 0.04 mM/l; p = 0.009). After the green tea intervention, MDA decreased 4.7% and TEAC increased 10%. Interleukin-6 (IL-6) serum levels decreased 12.7% after treatment (p = 0.03). Conclusions : a) the obese group had lower antioxidant capacity than eutrophic; and b) green tea supplementation ameliorated TEAC and MDA and reduced serum levels of IL-6 in obese women.
+Other Abstract
+ Publisher
+ INTRODUCCION: Introduccion: la obesidad se asocia con altos niveles de estres oxidativo (EO) e inflamacion. Existe mucha evidencia de que algunos polifenoles, como el te verde, tienen un impacto positivo en el estado del EO y, consecutivamente, en la inflamacion. Objetivos: los propositos de este estudio fueron: a) evaluar los biomarcadores de EO en mujeres obesas y de peso normal; y b) evaluar si la suplementacion con te verde tiene un impacto en el EO y biomarcadores de citoquinas inflamatorias de las mujeres obesas. Metodos: evaluamos mujeres obesas (indice de masa corporal [IMC] >= 40 kg/m2) y con peso normal (IMC entre 18,5 y 24,9 kg/m2). Se utilizaron muestras de sangre para determinar el malondialdehido (MDA), la capacidad antioxidante equivalente de trolox (TEAC) y las citoquinas inflamatorias. Elegimos al azar pacientes obesas (18 individuos) y luego les dimos suplementos de te verde durante ocho semanas. El analisis estadistico incluyo las pruebas de Shapiro-Wilk, Wilcoxon, t pareadas e independientes; p < 0,05 fueron considerados como significativos. Resultados: se reclutaron 42 mujeres obesas (IMC: 48,2 +/- 9,3 kg/m2) y 21 de peso normal (IMC: 22,5 +/- 2 kg/m2) con un promedio de edad de 36,2 +/- 9,1 anos. Los niveles sericos de MDA fueron mas altos en las personas obesas (2,52 +/- 0,31 micromol/L) que en las mujeres eutroficas (2,13 +/- 0,26 micromol/L; p = 0,000). Por otro lado, se observaron valores TEAC mas bajos en los obesos (0,75 +/- 0,06 mM/L) que en el grupo eutrofico (0,78 +/- 0,04 mM/L; p = 0,009). Despues de la intervencion con te verde, la MDA disminuyo 4.7% y el TEAC aumento 10%. Los niveles sericos de interleucina-6 (IL-6) disminuyeron 12.7% despues del tratamiento (p = 0,03). Conclusiones: a) mujeres obesas tienen menor capacidad antioxidante que las eutrofica; y b) la suplementacion con te verde mejora TEAC y MDA y redujo los niveles sericos de IL-6 en mujeres obesas.
+ Language: Spanish
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Cytokines). 0 (IL6 protein, human). 0 (Interleukin-6). 0 (Tea). 4Y8F71G49Q (Malondialdehyde).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.20960%2fnh.2159
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Noronha&issn=0212-1611&title=Nutricion+Hospitalaria&atitle=La+suplementacion+con+te+verde+mejora+los+biomarcadores+del+estres+oxidativo+y+modula+los+niveles+de+IL-6+de+la+circulacion+en+mujeres+obesas.&volume=36&issue=3&spage=583&epage=588&date=2019&doi=10.20960%2Fnh.2159&pmid=31192690&sid=OVID:medline
+
+<1634>
+Unique Identifier
+ 31192365
+Title
+ Ingestion of a Synbiotic Pasta by Those with Elevated Blood Sugar and Body Mass Index Results in Health Benefits.
+Source
+ Journal of Nutrition. 149(10):1687-1689, 2019 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Whisner CM
+Authors Full Name
+ Whisner, Corrie M.
+Institution
+ Whisner, Corrie M. College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Blood Glucose
+ Body Mass Index
+ Glucose
+ Humans
+ Lipids
+ Obesity
+ Prebiotics
+ *Probiotics
+ *Synbiotics
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). 0 (Prebiotics). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Comment.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fjn%2fnxz132
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Whisner&issn=0022-3166&title=Journal+of+Nutrition&atitle=Ingestion+of+a+Synbiotic+Pasta+by+Those+with+Elevated+Blood+Sugar+and+Body+Mass+Index+Results+in+Health+Benefits.&volume=149&issue=10&spage=1687&epage=1689&date=2019&doi=10.1093%2Fjn%2Fnxz132&pmid=31192365&sid=OVID:medline
+
+<1635>
+Unique Identifier
+ 31185686
+Title
+ A New Light on Vitamin D in Obesity: A Novel Association with Trimethylamine-N-Oxide (TMAO).
+Source
+ Nutrients. 11(6), 2019 Jun 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Barrea L; Muscogiuri G; Annunziata G; Laudisio D; de Alteriis G; Tenore GC; Colao A; Savastano S
+Authors Full Name
+ Barrea, Luigi; Muscogiuri, Giovanna; Annunziata, Giuseppe; Laudisio, Daniela; de Alteriis, Giulia; Tenore, Gian Carlo; Colao, Annamaria; Savastano, Silvia.
+Institution
+ Barrea, Luigi. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, 80131 Naples, Italy. luigi.barrea@unina.it.
+ Muscogiuri, Giovanna. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, 80131 Naples, Italy. giovanna.muscogiuri@gmail.com.
+ Annunziata, Giuseppe. Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy. giuseppe.annunziata@unina.it.
+ Laudisio, Daniela. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, 80131 Naples, Italy. daniela.laudisio@libero.it.
+ de Alteriis, Giulia. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, 80131 Naples, Italy. dealteriisgiulia@gmail.com.
+ Tenore, Gian Carlo. Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy. giancarlo.tenore@unina.it.
+ Colao, Annamaria. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, 80131 Naples, Italy. colao@unina.it.
+ Savastano, Silvia. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, 80131 Naples, Italy. sisavast@unina.it.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Humans
+ Male
+ *Methylamines/bl [Blood]
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Risk Factors
+ *Vitamin D/bl [Blood]
+ *Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/co [Complications]
+ Young Adult
+Keyword Heading
+ Fatty liver index (FLI).
+ Obesity
+ Trimethylamine N-oxide (TMAO)
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Abstract: Vitamin D deficiency and obesity are two public health problems extensively exacerbated over the last years. Among the several mechanisms proposed to account for the complex interplay between vitamin D and obesity, one that has gained particular attention is related to the emerging role of obesity-related changes in gut microbiota and gut-derived metabolites, such as Trimethylamine-N-oxide (TMAO). Vitamin D deficiency and high circulating TMAO levels are associated with body weight and the severity of non-alcoholic fatty liver disease (NAFLD). Considering the link of obesity with vitamin D on the one hand and obesity with TMAO on the other hand, and the central role of the liver in both the vitamin D and TMAO metabolism, the aim of this cross-sectional observational study was first, to confirm the possible inverse association between vitamin D and TMAO across different body mass index (BMI) classes and second, to investigate if this association could be influenced by the presence of NAFLD. One hundred and four adult subjects (50 males and 54 females; 35.38 +/- 7.49 years) were enrolled. The fatty liver index (FLI) was used as a proxy for the diagnosis of NAFLD. Vitamin D deficiency was found in 65 participants (62.5%), while 33 subjects (31.7%) had insufficient levels, and the remaining subjects had sufficient levels of vitamin D. Subjects with both vitamin D deficiency and FLI-NAFLD had the highest TMAO levels (p < 0.001). By stratifying the sample population according to the BMI classes, vitamin D levels decreased significantly along with the increase of plasma TMAO concentrations, with the lowest vitamin D levels and highest TMAO, respectively, in class III obesity. Vitamin D levels showed significant opposite associations with circulating levels of TMAO (r = -0.588, p < 0.001), but this association was no longer significant after the adjustment for FLI values. The highest values of TMAO were significantly associated with the severity of obesity (OR 7.92; p < 0.001), deficiency of vitamin D (OR 1.62; p < 0.001), and FLI-NAFLD (OR 3.79; p < 0.001). The most sensitive and specific cut-off for vitamin D to predict the circulating levels of TMAO was <=19.83 ng/mL (p < 0.001). In conclusion, our study suggests that high TMAO levels are associated with vitamin D deficiency and NAFLD. Further studies are required to investigate if there is a causality link or whether all of them are simply the consequence of obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Methylamines). 1406-16-2 (Vitamin D). FLD0K1SJ1A (trimethyloxamine).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11061310
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Barrea&issn=2072-6643&title=Nutrients&atitle=A+New+Light+on+Vitamin+D+in+Obesity%3A+A+Novel+Association+with+Trimethylamine-N-Oxide+%28TMAO%29.&volume=11&issue=6&spage=&epage=&date=2019&doi=10.3390%2Fnu11061310&pmid=31185686&sid=OVID:medline
+
+<1636>
+Unique Identifier
+ 31174521
+Title
+ Thyroid function, body mass index, and metabolic risk markers in euthyroid adults: a cohort study.
+Source
+ BMC Endocrine Disorders. 19(1):58, 2019 Jun 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xu R; Huang F; Zhang S; Lv Y; Liu Q
+Author NameID
+ Liu, Qingquan; ORCID: http://orcid.org/0000-0001-6888-5237
+Authors Full Name
+ Xu, Ranran; Huang, Fei; Zhang, Shijie; Lv, Yongman; Liu, Qingquan.
+Institution
+ Xu, Ranran. Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Hankou, Wuhan, 430030, People's Republic of China.
+ Huang, Fei. Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Hankou, Wuhan, 430030, People's Republic of China.
+ Zhang, Shijie. Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Hankou, Wuhan, 430030, People's Republic of China.
+ Lv, Yongman. Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Hankou, Wuhan, 430030, People's Republic of China. lvyongman@126.com.
+ Lv, Yongman. Health Management Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Hankou, Wuhan, 430030, People's Republic of China. lvyongman@126.com.
+ Liu, Qingquan. Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Hankou, Wuhan, 430030, People's Republic of China. qqliutj@163.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Case-Control Studies
+ Cohort Studies
+ Cross-Sectional Studies
+ Dyslipidemias/bl [Blood]
+ *Dyslipidemias/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ Overweight/bl [Blood]
+ *Overweight/ep [Epidemiology]
+ Prognosis
+ Thyroid Function Tests
+ Thyroid Gland/me [Metabolism]
+ *Thyroid Gland/pp [Physiopathology]
+ *Thyroid Hormones/bl [Blood]
+ Young Adult
+Keyword Heading
+ Body mass index
+ Dyslipidemia
+ Obesity
+ Thyroid-stimulating hormone
+ Thyroxine
+ Triiodothyronine
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In recent years, the relationship between thyroid stimulating hormone (TSH) and obesity has been widely discussed. However, it is unclear how thyroid hormone concentrations relate to body weight and its impact on metabolic risk markers. This study aimed to assess how thyroid function is linked to underweight, overweight, or obesity, and metabolic risk markers in adults.
+
+ METHODS: A total of 16,975 subjects, aged 18-80 years, who attended the Health Management Center of Tongji Hospital, Wuhan, China were enrolled in this study. Anthropometric and laboratory data were collected and analyzed.
+
+ RESULTS: Serum free triiodothyronine (fT3) and fT3/free thyroxine (fT4) ratio (fT3/fT4) were positively associated with body mass index (BMI) (P < 0.001), while there was a negative relationship between fT4 and BMI (P < 0.001) according to multivariable regression analysis adjusted for age and sex. Associations between thyroid hormone concentrations and markers of blood pressure, and lipid and glucose metabolism were identified after adjustment for age, sex, and BMI, with TSH being negatively associated with fasting blood glucose (FBG). fT3 was positively associated with systolic blood pressure and low-density lipoprotein-cholesterol, while fT4 was positively associated with diastolic blood pressure, FBG, and high-density lipoprotein-cholesterol (HDL-C), and negatively associated with hemoglobin A1c (HbA1c) and triglyceride. Finally, fT3/fT4 was positively associated with HbA1c and triglyceride, and negatively associated with HDL-C.
+
+ CONCLUSIONS: Overweight or obese participants had a high serum concentration of fT3, high fT3/fT4 ratio, and a low concentration of fT4. Underweight participants had high concentrations of fT4 and low concentrations of fT3. Thus, relationships between thyroid hormones and metabolic risk markers were identified which suggest that thyroid function might be one factor that influences body weight and the co-morbidities of obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Thyroid Hormones).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0383-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xu&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Thyroid+function%2C+body+mass+index%2C+and+metabolic+risk+markers+in+euthyroid+adults%3A+a+cohort+study.&volume=19&issue=1&spage=58&epage=&date=2019&doi=10.1186%2Fs12902-019-0383-2&pmid=31174521&sid=OVID:medline
+
+<1637>
+Unique Identifier
+ 31174495
+Title
+ Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: a retrospective study.
+Source
+ BMC Cancer. 19(1):547, 2019 Jun 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van Weelden WJ; Fasmer KE; Tangen IL; IntHout J; Abbink K; van Herwaarden AE; Krakstad C; Massuger LFAG; Haldorsen IS; Pijnenborg JMA
+Author NameID
+ van Weelden, Willem Jan; ORCID: http://orcid.org/0000-0002-5413-9556
+Authors Full Name
+ van Weelden, Willem Jan; Fasmer, Kristine Eldevik; Tangen, Ingvild L; IntHout, Joanna; Abbink, Karin; van Herwaarden, Antionius E; Krakstad, Camilla; Massuger, Leon F A G; Haldorsen, Ingfrid S; Pijnenborg, Johanna M A.
+Institution
+ van Weelden, Willem Jan. Department of Obstetrics and Gynecology, Radboud University Medical Center, Geert Grooteplein 10, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands. willemjan.vanweelden@radboudumc.nl.
+ Fasmer, Kristine Eldevik. Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital Bergen, Bergen, Norway.
+ Fasmer, Kristine Eldevik. Department of Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
+ Tangen, Ingvild L. Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
+ Tangen, Ingvild L. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
+ IntHout, Joanna. Department for Health Evidence, Radboud University Medical Center, Nijmegen, Netherlands.
+ Abbink, Karin. Department of Obstetrics and Gynecology, Radboud University Medical Center, Geert Grooteplein 10, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.
+ van Herwaarden, Antionius E. Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
+ Krakstad, Camilla. Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
+ Krakstad, Camilla. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
+ Massuger, Leon F A G. Department of Obstetrics and Gynecology, Radboud University Medical Center, Geert Grooteplein 10, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.
+ Haldorsen, Ingfrid S. Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital Bergen, Bergen, Norway.
+ Haldorsen, Ingfrid S. Department of Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
+ Pijnenborg, Johanna M A. Department of Obstetrics and Gynecology, Radboud University Medical Center, Geert Grooteplein 10, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.
+MeSH Subject Headings
+ *Adipose Tissue/pa [Pathology]
+ *Adiposity
+ Aged
+ Aged, 80 and over
+ Biomarkers
+ Body Mass Index
+ Comorbidity
+ *Endometrial Neoplasms/bl [Blood]
+ Endometrial Neoplasms/dg [Diagnostic Imaging]
+ Endometrial Neoplasms/et [Etiology]
+ *Endometrial Neoplasms/pa [Pathology]
+ Female
+ *Gonadal Steroid Hormones/bl [Blood]
+ Humans
+ Lipids/bl [Blood]
+ Middle Aged
+ Neoplasm Grading
+ Neoplasm Staging
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Organ Size
+ Retrospective Studies
+ Tomography, X-Ray Computed
+Keyword Heading
+ Endometrial cancer
+ Estradiol
+ Obesity
+ Subcutaneous fat
+ Visceral fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is an important cause of multiple cancer types, amongst which endometrial cancer (EC). The relation between obesity and cancer is complicated and involves alterations in insulin metabolism, response to inflammation and alterations in estradiol metabolism. Visceral obesity is assumed to play the most important role in the first two mechanisms, but its role in estradiol metabolism is unclear. Therefore, this retrospective study explores the relationship of body mass index (BMI), visceral fat volume (VAV) and subcutaneous fat volume (SAV) and serum levels of sex steroids and lipids in patients with endometrial cancer.
+
+ METHODS: Thirty-nine postmenopausal EC patients with available BMI, blood serum and Computed Tomography (CT) scans were included. Serum was analyzed for estradiol, dehydroepiandrosterone sulfate (DHEAS), androstenedione, testosterone, cholesterol, triglycerides and high (HDL), low (LDL) and non-high density (NHDL) lipoprotein. VAV and SAV were quantified on abdominal CT scan images. Findings were interpreted using pearson correlation coefficient and linear regression with commonality analysis.
+
+ RESULTS: Serum estradiol is moderately correlated with BMI (r = 0.62) and VAV (r = 0.58) and strongly correlated with SAV (r = 0.74) (p < 0.001 for all). SAV contributes more to estradiol levels than VAV (10.3% for SAV, 1.4% for VAV, 35.9% for SAV and VAV, p = 0.01). Other sex steroids and lipids have weak and moderate correlations with VAV or SAV.
+
+ CONCLUSIONS: This study shows that serum estradiol is correlated with BMI and other fat-distribution measures in postmenopausal endometrial cancer patients. Subcutaneous fat tissue contributes more to the estradiol levels indicating that subcutaneous fat might be relevant in endometrial cancer carcinogenesis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Gonadal Steroid Hormones). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12885-019-5770-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+Weelden&issn=1471-2407&title=BMC+Cancer&atitle=Impact+of+body+mass+index+and+fat+distribution+on+sex+steroid+levels+in+endometrial+carcinoma%3A+a+retrospective+study.&volume=19&issue=1&spage=547&epage=&date=2019&doi=10.1186%2Fs12885-019-5770-6&pmid=31174495&sid=OVID:medline
+
+<1638>
+Unique Identifier
+ 31170925
+Title
+ Joint associations of obesity and estimated GFR with clinical outcomes: a population-based cohort study.
+Source
+ BMC Nephrology. 20(1):204, 2019 06 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tonelli M; Wiebe N; Kovesdy CP; James MT; Klarenbach SW; Manns BJ; Hemmelgarn BR
+Corporate Author
+ Alberta Kidney Disease Network
+Authors Full Name
+ Tonelli, Marcello; Wiebe, Natasha; Kovesdy, Csaba P; James, Matthew T; Klarenbach, Scott W; Manns, Braden J; Hemmelgarn, Brenda R.
+Institution
+ Tonelli, Marcello. Department of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada. cello@ucalgary.ca.
+ Wiebe, Natasha. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
+ Kovesdy, Csaba P. College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
+ James, Matthew T. Department of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
+ Klarenbach, Scott W. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
+ Manns, Braden J. Department of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
+ Hemmelgarn, Brenda R. Department of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
+MeSH Subject Headings
+ Alberta/ep [Epidemiology]
+ Albuminuria/di [Diagnosis]
+ Albuminuria/ep [Epidemiology]
+ *Albuminuria
+ Biomarkers
+ Body Mass Index
+ Disease Progression
+ Female
+ Glomerular Filtration Rate
+ Humans
+ Kidney Failure, Chronic/mo [Mortality]
+ *Kidney Function Tests/mt [Methods]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ *Obesity
+ Preventive Health Services
+ Renal Insufficiency, Chronic/di [Diagnosis]
+ Renal Insufficiency, Chronic/ep [Epidemiology]
+ *Renal Insufficiency, Chronic
+ Risk Factors
+Keyword Heading
+ Albuminuria
+ Obesity
+ eGFR
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Despite the interrelationships between obesity, eGFR and albuminuria, few large studies examine how obesity modifies the association between these markers of kidney function and adverse clinical outcomes.
+
+ METHODS: We examined the joint associations between obesity, eGFR and albuminuria on four clinical outcomes (death, end-stage renal disease [ESRD], myocardial infarction [MI], and placement in a long-term care facility) using a population-based cohort with procedures from Alberta. Obesity was defined by body mass index >=35 kg/m2 as defined by a fee modifier applied to an eligible procedure.
+
+ RESULTS: We studied 1,293,362 participants, of whom 171,650 (13.3%) had documented obesity (BMI >= 35 kg/m2 based on claims data) and 1,121,712 (86.7%) did not. The association between eGFR and death was J-shaped for participants with and without documented obesity. After full adjustment, obesity tended to be associated with slightly lower odds of mortality (OR range 0.71-1.02; p for interaction between obesity and eGFR 0.008). For participants with and without obesity, the adjusted odds of ESRD were lowest for participants with eGFR > 90 mL/min*1.73m2 and increased with lower eGFR, with no evidence of an interaction with obesity (p = 0.37). Although albuminuria and obesity were both associated with higher odds of ESRD, the excess risk associated with obesity was substantially attenuated at higher levels of albuminuria (p for interaction 0.0006). The excess risk of MI associated with obesity was observed at eGFR > 60 mL/min*1.73m2 but not at lower eGFR (p for interaction < 0.0001). Participants with obesity had a higher adjusted likelihood of placement in long-term care than those without, and the likelihood of such placement was higher at lower eGFR for those with and without obesity (p for interaction = 0.57).
+
+ CONCLUSIONS: We found significant interactions between obesity and eGFR and/or albuminuria on the likelihood of adverse outcomes including death and ESRD. Since obesity is common, risk prediction tools for people with CKD might be improved by adding information on BMI or other proxies for body size in addition to eGFR and albuminuria.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12882-019-1351-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tonelli&issn=1471-2369&title=BMC+Nephrology&atitle=Joint+associations+of+obesity+and+estimated+GFR+with+clinical+outcomes%3A+a+population-based+cohort+study.&volume=20&issue=1&spage=204&epage=&date=2019&doi=10.1186%2Fs12882-019-1351-9&pmid=31170925&sid=OVID:medline
+
+<1639>
+Unique Identifier
+ 31169693
+Title
+ Association between salivary amylase enzyme activity and obesity in Saudi Arabia.
+Source
+ Medicine. 98(23):e15878, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aldossari NM; El Gabry EE; Gawish GEH
+Authors Full Name
+ Aldossari, Norah Mubarak; El Gabry, Eman E; Gawish, Gihan E H.
+Institution
+ Aldossari, Norah Mubarak. Department of Home Economics, College of Education - Wadi Addawasir, Prince Sattam Bin Abdulaziz University.
+ Aldossari, Norah Mubarak. Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Saudi Arabia.
+ El Gabry, Eman E. Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Saudi Arabia.
+ El Gabry, Eman E. Medical Biochemistry, Cairo University, National Nutrition Institute, Egypt.
+ Gawish, Gihan E H. Medical Biochemistry Department., College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU).
+ Gawish, Gihan E H. Saudi Society for Clinical Chemistry, SCFHS, Saudi Arabia.
+MeSH Subject Headings
+ Adult
+ *Amylases/an [Analysis]
+ Biomarkers
+ Blood Pressure
+ Body Mass Index
+ Body Weights and Measures
+ Diabetes Mellitus/ep [Epidemiology]
+ Diet
+ Dyslipidemias/ep [Epidemiology]
+ Energy Intake
+ Female
+ Genetic Predisposition to Disease
+ Humans
+ Hypertension/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ *Saliva/ch [Chemistry]
+ Saudi Arabia/ep [Epidemiology]
+ Young Adult
+Abstract
+ Obesity is a significant public health concern that predisposes individuals to a high risk of premature mortality. Previous studies also reported that low serum concentrations of AMY1 have been associated with obesity. The aimed of the study to assess the relationship between salivary amylase (AMY1) activity and body mass index (BMI) in Saudi male and female adults in Riyadh. This study included a total of 200 (100 individuals who were overweight and obese and 100 who had normal body weight [control individuals]) Saudi participants aged 20 to 50 years old. They were recruited from physical fitness clubs and were school employees in Riyadh City. The dietary food intake was assessed using a 24-hour dietary recall. The activity of the AMY1 was measured using a microplate fluorescence reader. A significant (P <= .05) increase was observed in the incidence of hypertension, dyslipidemia, diabetes mellitus (DM), and family history of overweight and obesity in overweight and obese individuals than in the control individuals, and these were in parallel to the significant increase in weight, waist circumference (WC), hip circumference (HC), systolic blood pressure (SBP), diastolic blood pressure (DBP), and BMI. A significant (P <= .05) increase was also observed in the carbohydrate and total fat dietary intake of overweight and obese individuals in relation to the respective dietary reference intake (DRI) values. AMY1 activity was significantly lower than the reference values in the overweight and obese group. Furthermore, AMY1 activity was significantly (P <= .05) reverse with weight, WC, HC, and BMI in both males and females in the overweight and obese group. In conclusion, the Saudi overweight and obese population seems to be at risk of low AMY1, which correlates with their obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-2-1 (Amylases).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fMD.0000000000015878
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aldossari&issn=0025-7974&title=Medicine&atitle=Association+between+salivary+amylase+enzyme+activity+and+obesity+in+Saudi+Arabia.&volume=98&issue=23&spage=e15878&epage=&date=2019&doi=10.1097%2FMD.0000000000015878&pmid=31169693&sid=OVID:medline
+
+<1640>
+Unique Identifier
+ 31169533
+Title
+ Impact of Obesity and Alanine Aminotransferase Levels on the Diagnostic Accuracy for Advanced Liver Fibrosis of Noninvasive Tools in Patients With Nonalcoholic Fatty Liver Disease.
+Source
+ American Journal of Gastroenterology. 114(6):916-928, 2019 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Petta S; Wai-Sun Wong V; Bugianesi E; Fracanzani AL; Camma C; Hiriart JB; Lai-Hung Wong G; Vergniol J; Wing-Hung Chan A; Giannetti A; Merrouche W; Lik-Yuen Chan H; Le-Bail B; Lombardi R; Guastella S; Craxi A; de Ledinghen V
+Authors Full Name
+ Petta, Salvatore; Wai-Sun Wong, Vincent; Bugianesi, Elisabetta; Fracanzani, Anna Ludovica; Camma, Calogero; Hiriart, Jean-Baptiste; Lai-Hung Wong, Grace; Vergniol, Julien; Wing-Hung Chan, Anthony; Giannetti, Aurora; Merrouche, Wassil; Lik-Yuen Chan, Henry; Le-Bail, Brigitte; Lombardi, Rosa; Guastella, Salvatore; Craxi, Antonio; de Ledinghen, Victor.
+Institution
+ Petta, Salvatore. Sezione di Gastroenterologia, Di.Bi.M.I.S., University of Palermo, Italy.
+ Wai-Sun Wong, Vincent. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
+ Wai-Sun Wong, Vincent. State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.
+ Bugianesi, Elisabetta. Division of Gastroenterology, Department of Medical Sciences, University of Torino, Torino, Italy.
+ Fracanzani, Anna Ludovica. Department of Pathophysiology and Transplantation, Ca' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Italy.
+ Camma, Calogero. Sezione di Gastroenterologia, Di.Bi.M.I.S., University of Palermo, Italy.
+ Hiriart, Jean-Baptiste. Centre d'Investigation de la Fibrose hepatique, Hopital Haut-Leveque, Bordeaux University Hospital, Pessac, France.
+ Lai-Hung Wong, Grace. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
+ Lai-Hung Wong, Grace. State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.
+ Vergniol, Julien. Centre d'Investigation de la Fibrose hepatique, Hopital Haut-Leveque, Bordeaux University Hospital, Pessac, France.
+ Wing-Hung Chan, Anthony. Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong.
+ Giannetti, Aurora. Sezione di Gastroenterologia, Di.Bi.M.I.S., University of Palermo, Italy.
+ Merrouche, Wassil. Centre d'Investigation de la Fibrose hepatique, Hopital Haut-Leveque, Bordeaux University Hospital, Pessac, France.
+ Lik-Yuen Chan, Henry. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
+ Lik-Yuen Chan, Henry. State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.
+ Le-Bail, Brigitte. Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong.
+ Le-Bail, Brigitte. INSERM U1053, Bordeaux University, Bordeaux, France.
+ Lombardi, Rosa. Department of Pathophysiology and Transplantation, Ca' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Italy.
+ Guastella, Salvatore. Sezione di Gastroenterologia, Di.Bi.M.I.S., University of Palermo, Italy.
+ Craxi, Antonio. Sezione di Gastroenterologia, Di.Bi.M.I.S., University of Palermo, Italy.
+ de Ledinghen, Victor. Centre d'Investigation de la Fibrose hepatique, Hopital Haut-Leveque, Bordeaux University Hospital, Pessac, France.
+ de Ledinghen, Victor. Service de Pathologie, Hopital Pellegrin, Bordeaux University Hospital, Bordeaux, France.
+MeSH Subject Headings
+ *Alanine Transaminase/bl [Blood]
+ Aspartate Aminotransferases/bl [Blood]
+ Biomarkers/bl [Blood]
+ Biopsy
+ *Elasticity Imaging Techniques/mt [Methods]
+ Female
+ Humans
+ *Liver/dg [Diagnostic Imaging]
+ Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/en [Enzymology]
+ *Liver Cirrhosis/et [Etiology]
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/co [Complications]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/en [Enzymology]
+ *Obesity/co [Complications]
+ Obesity/en [Enzymology]
+ Predictive Value of Tests
+ ROC Curve
+ Severity of Illness Index
+Abstract
+ INTRODUCTION: Some evidence suggests an interference of obesity and alanine aminotransferase (ALT) levels on the diagnostic accuracy for advanced fibrosis of noninvasive tools such as liver stiffness measurement (LSM) by FibroScan, Fibrosis-4 (FIB-4), and nonalcoholic fatty liver disease fibrosis score (NFS). We assessed whether the diagnostic accuracy of LSM, Fibrosis-4 (FIB-4), and NFS and strategies based on the combination of these tools is affected by obesity and/or ALT levels.
+
+ METHODS: We analyzed data from 968 patients with a histological diagnosis of nonalcoholic fatty liver disease. FIB-4, NFS, and LSM by FibroScan were measured.
+
+ RESULTS: LSM was better than both FIB-4 and NFS for staging F3-F4 fibrosis area under the receiver operating characteristic curve test (AUC) 0.863, 0.777, and 0.765, respectively; P < 0.001 for both), showing higher accuracy and higher negative predictive value (NPV), but lower positive predictive value (PPV). LSM worked less well in high ALT (>100 IU) (AUC 0.811 vs 0.877, P = 0.04; PPV 57.5% vs 62.4%; NPV 90.7% vs 94%) or obese patients (AUC 0.786 vs 0.902, P < 0.001; PPV 58.7% vs 64.8%; NPV 88.3% vs 95.2%), the latter not being affected by the M or XL probe. Consistently, LSM worked better in terms of AUC and accuracy compared with both FIB-4 and NFS only in nonobese or high ALT patients, even with always keeping a slightly lower PPV. A serial combination of FIB-4 or NFS with LSM as the second test in patients in the gray area of the first test retained-in most scenarios-similar PPV and NPV compared with LSM alone. These strategies also increased the diagnostic accuracy of about 20% in all groups of patients, even if with a lower overall accuracy in obese patients (71.3% and 67.1% for FIB-4 and NFS as the first test, respectively) compared to nonobese patients (81.9% and 82.4% for FIB-4 and NFS as the first test, respectively).
+
+ CONCLUSIONS: All tested noninvasive tools have overall better NPV than PPV. LSM has a better diagnostic accuracy for advanced fibrosis than both FIB-4 and NFS only in nonobese and/or low ALT patients. Serial combination strategies are better than a single tool strategy, regardless of obesity and ALT levels, although the accuracy is lower in obese patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Multicenter Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.14309%2fajg.0000000000000153
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Petta&issn=0002-9270&title=American+Journal+of+Gastroenterology&atitle=Impact+of+Obesity+and+Alanine+Aminotransferase+Levels+on+the+Diagnostic+Accuracy+for+Advanced+Liver+Fibrosis+of+Noninvasive+Tools+in+Patients+With+Nonalcoholic+Fatty+Liver+Disease.&volume=114&issue=6&spage=916&epage=928&date=2019&doi=10.14309%2Fajg.0000000000000153&pmid=31169533&sid=OVID:medline
+
+<1641>
+Unique Identifier
+ 31167664
+Title
+ Good glycemic control of gestational diabetes mellitus is associated with the attenuation of future maternal cardiovascular risk: a retrospective cohort study.
+Source
+ Cardiovascular Diabetology. 18(1):75, 2019 06 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yefet E; Schwartz N; Sliman B; Ishay A; Nachum Z
+Author NameID
+ Yefet, Enav; ORCID: https://orcid.org/0000-0002-3102-0739
+Authors Full Name
+ Yefet, Enav; Schwartz, Naama; Sliman, Basma; Ishay, Avraham; Nachum, Zohar.
+Institution
+ Yefet, Enav. Department of Obstetrics & Gynecology, Emek Medical Center, Afula, Israel. enavy1@gmail.com.
+ Schwartz, Naama. Research Authority, Emek Medical Center, Afula, Israel.
+ Sliman, Basma. Department of Obstetrics & Gynecology, Emek Medical Center, Afula, Israel.
+ Ishay, Avraham. Endocrine & Diabetes Unit, Emek Medical Center, Afula, Israel.
+ Ishay, Avraham. Rappaport Faculty of Medicine, Technion, Haifa, Israel.
+ Nachum, Zohar. Department of Obstetrics & Gynecology, Emek Medical Center, Afula, Israel.
+ Nachum, Zohar. Rappaport Faculty of Medicine, Technion, Haifa, Israel.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ Diabetes, Gestational/bl [Blood]
+ Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/ep [Epidemiology]
+ *Diabetes, Gestational/th [Therapy]
+ Dyslipidemias/ep [Epidemiology]
+ *Dyslipidemias/pc [Prevention & Control]
+ Female
+ Humans
+ Hypertension/ep [Epidemiology]
+ Hypertension/pc [Prevention & Control]
+ Israel/ep [Epidemiology]
+ Maternal Health
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Obesity/pc [Prevention & Control]
+ Pregnancy
+ Prevalence
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ Dyslipidemia
+ Gestational diabetes mellitus
+ Glycemic control
+ Hypertension
+ Metabolic syndrome
+ Obesity
+ Pregnancy
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: To examine whether glycemic control of gestational diabetes mellitus (GDM) could modify the risk for future maternal metabolic and cardiovascular morbidities.
+
+ METHODS: A retrospective cohort study of women with a first diagnosis of GDM who delivered between 1991 and 2011. Women were divided into groups of good and poor glycemic control, defined as a mean daily glucose of up to 95 mg/dL (N = 230) and more than 95 mg/dL (N = 216), respectively. In addition, a control group of women without GDM (N = 352) was also analyzed. The primary outcomes were the development of type 2 diabetes mellitus (T2DM), obesity, hypertension, or dyslipidemia.
+
+ RESULTS: Mean follow-up time was 15.8 +/- 5.1 years. Assessment was performed at a maternal age of 45 +/- 7 years. The rates of the study outcomes in the control, GDM with good glycemic control and GDM with poor glycemic control were as follows: T2DM [19 (5.4%), 87 (38%), 127 (57%)]; hypertension [44 (13%), 42 (18%), 44 (20%)]; obesity [111 (32%), 112 (48%), 129 (58%)]; and dyslipidemia [49 (14%), 67 (29%), 106 (48%)]. Glycemic control was an independent risk factor for T2DM in multivariate Cox regression analysis (hazard ratio (HR) for poor glycemic control vs. controls 10.7 95% CI [6.0-19.0], good glycemic control vs. control HR 6.0 [3.3-10.8], and poor glycemic control vs. good glycemic control HR 1.8 [1.3-2.4]). Glycemic control was also an independent risk factor for dyslipidemia (poor glycemic control vs. controls HR 3.7 [2.3-5.8], good glycemic control vs. controls HR 2.0 [1.2-3.2], and poor glycemic control vs. good glycemic control HR 1.8 1.8 [1.3-2.6]). The fasting glucose level during oral glucose tolerance test (OGTT) was also an independent risk factor for these complications. The interaction term between glycemic control and the fasting value of the OGTT was not statistically significant, suggesting that the effect of glycemic control on the rate of future T2DM and dyslipidemia was not modified by the baseline severity of GDM.
+
+ CONCLUSION: GDM and especially poor glycemic control are associated with T2DM and dyslipidemia. Strict glycemic control for reducing that risk should be evaluated in prospective trials.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12933-019-0881-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yefet&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Good+glycemic+control+of+gestational+diabetes+mellitus+is+associated+with+the+attenuation+of+future+maternal+cardiovascular+risk%3A+a+retrospective+cohort+study.&volume=18&issue=1&spage=75&epage=&date=2019&doi=10.1186%2Fs12933-019-0881-6&pmid=31167664&sid=OVID:medline
+
+<1642>
+Unique Identifier
+ 31162597
+Title
+ Glucose- and Lipid-Related Biomarkers Are Affected in Healthy Obese or Hyperglycemic Adults Consuming a Whole-Grain Pasta Enriched in Prebiotics and Probiotics: A 12-Week Randomized Controlled Trial.
+Source
+ Journal of Nutrition. 149(10):1714-1723, 2019 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Angelino D; Martina A; Rosi A; Veronesi L; Antonini M; Mennella I; Vitaglione P; Grioni S; Brighenti F; Zavaroni I; Fares C; Torriani S; Pellegrini N
+Authors Full Name
+ Angelino, Donato; Martina, Alessia; Rosi, Alice; Veronesi, Licia; Antonini, Monica; Mennella, Ilario; Vitaglione, Paola; Grioni, Sara; Brighenti, Furio; Zavaroni, Ivana; Fares, Clara; Torriani, Sandra; Pellegrini, Nicoletta.
+Institution
+ Angelino, Donato. Human Nutrition Unit, Department of Food and Drugs.
+ Martina, Alessia. Department of Biotechnology, University of Verona, Verona, Italy.
+ Rosi, Alice. Human Nutrition Unit, Department of Food and Drugs.
+ Veronesi, Licia. Public Health Unit, Department of Medicine and Surgery.
+ Antonini, Monica. Division of Endocrinology, Department of Medicine and Surgery, University of Parma, Parma, Italy.
+ Mennella, Ilario. Department of Agricultural and Food Science, University of Naples "Federico II", Portici, Naples, Italy.
+ Vitaglione, Paola. Department of Agricultural and Food Science, University of Naples "Federico II", Portici, Naples, Italy.
+ Grioni, Sara. Epidemiology and Prevention Unit, Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Italy.
+ Brighenti, Furio. Human Nutrition Unit, Department of Food and Drugs.
+ Zavaroni, Ivana. Division of Endocrinology, Department of Medicine and Surgery, University of Parma, Parma, Italy.
+ Fares, Clara. Council for Agricultural Research and Economics-Centre for Cereal Research and Industrial Crops, Foggia, Italy.
+ Torriani, Sandra. Department of Biotechnology, University of Verona, Verona, Italy.
+ Pellegrini, Nicoletta. Human Nutrition Unit, Department of Food and Drugs.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ Diet
+ Female
+ Food, Fortified
+ *Glucose/me [Metabolism]
+ Humans
+ Hyperglycemia/bl [Blood]
+ Hyperglycemia/dh [Diet Therapy]
+ *Hyperglycemia
+ *Lipid Metabolism
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Nutritional Status
+ Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ *Obesity
+ *Prebiotics
+ *Probiotics
+ Single-Blind Method
+ Whole Grains
+Keyword Heading
+ Bacillus coagulans
+ gastrointestinal tract
+ inflammation
+ obesity
+ randomized controlled trial
+ resistin
+ whole grain
+ beta-glucans
+ gamma-glutamyltransferase
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Synbiotic foods, which combine the action of prebiotics and probiotics along the gastrointestinal tract, can affect inflammatory and glucose-related markers.
+
+ OBJECTIVE: The aim of this study was to investigate the effects on inflammatory and glycemia-related markers of a whole-grain pasta containing barley beta-glucans and Bacillus coagulans BC30, 6086 in healthy overweight or obese volunteers.
+
+ METHODS: A single-blind, parallel, randomized, placebo-controlled dietary intervention study was carried out. Forty-one healthy sedentary overweight (body mass index [BMI] 25-29.9 kg/m2) and obese (BMI >=30) volunteers, aged 30-65 y and low consumers of fruit and vegetables, ate 1 serving/d of whole-grain control (CTR) or innovative (INN) pasta for 12 wk and maintained their habitual diets. Biological samples were collected at baseline and every 4 wk for primary (plasma high-sensitivity C-reactive protein [hs-CRP] and fasting plasma lipid profile) and secondary outcomes (glycemia-related markers, blood pressure, fecal microbiota composition, and body weight). Between (CTR compared with INN) and within (among weeks) group differences were tested for the whole population and for subgroups stratified by baseline values of BMI (>=30) and glycemia (>=100 mg/dL).
+
+ RESULTS: INN or CTR pasta consumption had no effect on primary and secondary outcomes over time, except for a significant increase in plasma gamma-glutamyltransferase (GGT) after 12 wk of CTR pasta consumption. Comparisons between intervention groups revealed differences only at 12 wk: plasma GGT was higher in the CTR group; plasma hs-CRP, plasma LDL/HDL cholesterol ratio, and Bifidobacterium spp. were lower in the INN subgroup of obese volunteers; plasma resistin was lower and Faecalibacterium prausnitzii abundance was higher in the INN subgroup of hyperglycemic volunteers.
+
+ CONCLUSIONS: A daily serving of a synbiotic whole-grain pasta had limited effects on primary and secondary outcomes in the entire group of volunteers but affected glycemia- and lipid-related markers and resistin in a subgroup of healthy obese or hyperglycemic volunteers. This trial was registered at clinicaltrials.gov as NCT02236533. Copyright © American Society for Nutrition 2019.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). 0 (Prebiotics). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fjn%2fnxz071
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Angelino&issn=0022-3166&title=Journal+of+Nutrition&atitle=Glucose-+and+Lipid-Related+Biomarkers+Are+Affected+in+Healthy+Obese+or+Hyperglycemic+Adults+Consuming+a+Whole-Grain+Pasta+Enriched+in+Prebiotics+and+Probiotics%3A+A+12-Week+Randomized+Controlled+Trial.&volume=149&issue=10&spage=1714&epage=1723&date=2019&doi=10.1093%2Fjn%2Fnxz071&pmid=31162597&sid=OVID:medline
+
+<1643>
+Unique Identifier
+ 31162551
+Title
+ Association of Galectin-3 With Diabetes Mellitus in the Dallas Heart Study.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 104(10):4449-4458, 2019 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vora A; de Lemos JA; Ayers C; Grodin JL; Lingvay I
+Authors Full Name
+ Vora, Amy; de Lemos, James A; Ayers, Colby; Grodin, Justin L; Lingvay, Ildiko.
+Institution
+ Vora, Amy. Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Texas.
+ de Lemos, James A. Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Texas.
+ Ayers, Colby. Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Texas.
+ Grodin, Justin L. Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Texas.
+ Lingvay, Ildiko. Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Texas.
+ Lingvay, Ildiko. Department of Clinical Sciences, University of Texas Southwestern Medical Center at Dallas, Texas.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Comorbidity
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Ethnicity
+ Female
+ Follow-Up Studies
+ *Galectin 3/bl [Blood]
+ Humans
+ *Hypertension/bl [Blood]
+ Hypertension/di [Diagnosis]
+ Hypertension/ep [Epidemiology]
+ Insulin Resistance
+ Logistic Models
+ Male
+ Middle Aged
+ Multivariate Analysis
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Population Surveillance
+ Prevalence
+ Retrospective Studies
+ Risk Assessment
+ Severity of Illness Index
+ Texas
+Abstract
+ CONTEXT: Galectin-3 is a biomarker associated with inflammation and fibrosis in cardiac, liver, and renal disease. Galectin-3 is higher in overweight and obese individuals; whether an association with diabetes exists independent of weight is unknown.
+
+ OBJECTIVE: To evaluate if galectin-3 is associated with diabetes mellitus.
+
+ DESIGN: We performed measurements of galectin-3 among participants in the Dallas Heart Study (DHS) Phases 1 and 2 (DHS-1 and DHS-2; n = 3392, and n = 3194, respectively). Of these, 1989 participants were evaluated longitudinally in both studies. Associations of galectin-3 with prevalent and incident type 2 diabetes were determined using logistic regression models. Associations of galectin-3 with relevant biomarkers and fat compartments were evaluated using Spearman correlation coefficients and multivariable linear regression models, respectively.
+
+ SETTING AND PARTICIPANTS: DHS is a population-based, single-site, multiethnic study conducted in Dallas County, Texas, with oversampling to comprise 50% blacks.
+
+ RESULTS: Galectin-3 levels were associated with diabetes prevalence in DHS-1 [OR 1.56 per SD change in log-galectin (95% CI 1.41 to 1.73)] and DHS-2 [OR 1.86 (95% CI 1.67 to 2.06)]. Galectin-3 levels in DHS-1 also associated with incident diabetes mellitus over the 7.1 (interquartile range 6.6 to 7.6)-year follow-up period [OR 1.34 (95% CI 1.14 to 1.58)]. These associations maintained significance in models adjusted for traditional metabolic risk factors (age, sex, race, body mass index, and hypertension) and renal function. Galectin-3 levels correlated with levels of biomarkers implicated in inflammation (high-sensitivity C-reactive peptide, IL-18, monocyte chemoattractant protein 1, soluble TNF receptor 1A, myeloperoxidase), insulin secretion (C-peptide and C-peptide/homeostatic model assessment for insulin resistance), and subcutaneous adiposity.
+
+ CONCLUSIONS: Galectin-3 is associated with diabetes prevalence and incidence, possibly through the inflammatory pathway contributing to beta-cell fibrosis and impaired insulin secretion. Copyright © 2019 Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Galectin 3).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1210%2fjc.2019-00398
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vora&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Association+of+Galectin-3+With+Diabetes+Mellitus+in+the+Dallas+Heart+Study.&volume=104&issue=10&spage=4449&epage=4458&date=2019&doi=10.1210%2Fjc.2019-00398&pmid=31162551&sid=OVID:medline
+
+<1644>
+Unique Identifier
+ 31161561
+Title
+ High dose of linagliptin induces thermogenic beige adipocytes in the subcutaneous white adipose tissue in diet-induced obese C57BL/6 mice.
+Source
+ Endocrine. 65(2):252-262, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Oliveira Correia BR; Rachid TL; de Oliveira Glauser JS; Martins FF; Mandarim-de-Lacerda CA; Souza-Mello V
+Author NameID
+ Mandarim-de-Lacerda, Carlos Alberto; ORCID: https://orcid.org/0000-0003-4134-7978
+ Souza-Mello, Vanessa; ORCID: https://orcid.org/0000-0002-2510-9569
+Authors Full Name
+ de Oliveira Correia, Byanca Ramos; Rachid, Tamiris Lima; de Oliveira Glauser, Jade Sancha; Martins, Fabiane Ferreira; Mandarim-de-Lacerda, Carlos Alberto; Souza-Mello, Vanessa.
+Institution
+ de Oliveira Correia, Byanca Ramos. Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
+ Rachid, Tamiris Lima. Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
+ de Oliveira Glauser, Jade Sancha. Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
+ Martins, Fabiane Ferreira. Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
+ Mandarim-de-Lacerda, Carlos Alberto. Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
+ Souza-Mello, Vanessa. Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil. souzamello.uerj@gmail.com.
+MeSH Subject Headings
+ Adipocytes, Brown
+ Adiposity
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Dipeptidyl-Peptidase IV Inhibitors/pd [Pharmacology]
+ *Dipeptidyl-Peptidase IV Inhibitors/tu [Therapeutic Use]
+ Disease Models, Animal
+ Insulin/bl [Blood]
+ Linagliptin/pd [Pharmacology]
+ *Linagliptin/tu [Therapeutic Use]
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ Random Allocation
+ Subcutaneous Fat/cy [Cytology]
+ *Subcutaneous Fat/de [Drug Effects]
+ Subcutaneous Fat/me [Metabolism]
+ *Thermogenesis/de [Drug Effects]
+Keyword Heading
+ Browning
+ Linagliptin
+ Obesity
+ Subcutaneous white adipose tissue
+ Thermogenesis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: To verify whether the treatment with linagliptin induces the browning of the subcutaneous WAT (sWAT) and thermogenesis in murine diet-induced obesity (DIO) model.
+
+ METHODS: Forty animals were randomly assigned to receive a control diet (C, 10% lipids as energy) or a high-fat diet (HF, 50% lipids as energy) for 10 weeks. Each group was re-divided to begin the 5-week treatment, totalizing four experimental groups: C, C-L (C plus linagliptin, 30 mg/kg body mass; BM), HF, and HF-L (HF plus linagliptin, 30 mg/kg BM). The drug was mixed with diet.
+
+ RESULTS: HF animals showed overweight, glucose intolerance, and a greater cross-sectional area of adipocytes. The treatment with linagliptin was able to normalize the BM, restore the glucose tolerance and the cross-sectional area of adipocytes. These observations comply with the observation of UCP1-positive multilocular adipocytes in the sWAT of treated animals. Both treated groups (C-L and HF-L) showed high expression of thermogenic and type 2 cytokines genes, which agree with the enhanced body temperature and the lower respiratory exchange ratio, implying enhanced thermogenesis with the use of lipids as fuel.
+
+ CONCLUSIONS: The reduced BM, the enhanced body temperature, and the presence of positive UCP1 beige cells in the sWAT point to the activation of the browning cascade on the sWAT of linagliptin-treated mice, and hence, linagliptin could induce the thermogenic pathway as a pleiotropic effect that can have translational potential.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dipeptidyl-Peptidase IV Inhibitors). 0 (Insulin). 3X29ZEJ4R2 (Linagliptin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs12020-019-01969-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Oliveira+Correia&issn=1355-008X&title=Endocrine&atitle=High+dose+of+linagliptin+induces+thermogenic+beige+adipocytes+in+the+subcutaneous+white+adipose+tissue+in+diet-induced+obese+C57BL%2F6+mice.&volume=65&issue=2&spage=252&epage=262&date=2019&doi=10.1007%2Fs12020-019-01969-y&pmid=31161561&sid=OVID:medline
+
+<1645>
+Unique Identifier
+ 31159801
+Title
+ Total adiponectin in overweight and obese subjects and its response to visceral fat loss.
+Source
+ BMC Endocrine Disorders. 19(1):55, 2019 Jun 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gariballa S; Alkaabi J; Yasin J; Al Essa A
+Authors Full Name
+ Gariballa, Salah; Alkaabi, Juma; Yasin, Javed; Al Essa, Awad.
+Institution
+ Gariballa, Salah. Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. s.gariballa@uaeu.ac.ae.
+ Alkaabi, Juma. Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
+ Yasin, Javed. Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
+ Al Essa, Awad. Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Composition
+ Body Mass Index
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ *Intra-Abdominal Fat/pp [Physiopathology]
+ Longitudinal Studies
+ Male
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Overweight/bl [Blood]
+ Overweight/di [Diagnosis]
+ Overweight/ep [Epidemiology]
+ Prognosis
+ Prospective Studies
+ United Arab Emirates/ep [Epidemiology]
+ Waist Circumference
+ Young Adult
+Keyword Heading
+ Adiponectin
+ Diet
+ Obesity
+ Visceral fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Visceral obesity and related diabetes is reaching epidemic proportions in the United Arab Emirates (UAE). Adiponectin is a hormone that is secreted by adipose tissue and may play an important role in obesity-related morbidity. The aim of this study was to investigate total adiponectin levels in overweight and obese UAE subjects visiting health care facilities for weight management.
+
+ METHODS: All overweight and obese subjects visiting community health centers were invited to take part in the study. Two hundred and six participants received individualized structured dietary education for weight management. Demographic data, anthropometric measurements and fasting venous blood samples were taken for measurements of total adiponectin and markers of inflammation and nutritional status at baseline and follow up. Multivariate analysis was performed to determine the independent effects of prognostic factors on serum adiponectin levels.
+
+ RESULTS: A total of 193 (93%) females with a mean age (+/-SD) 36 +/- 11 years were included in the analysis. During a follow up period of 427 +/- 223 days, participants received 13 +/- 5 structured dietary education sessions. We observed decreased levels of total adiponectin with increasing quartiles of both waist circumference (WC) and body mass index (BMI). Male gender and history of both gestational and type 2 diabetes were associated with significantly lower total adiponectin levels (p < 0.05). After adjusting for age, gender, BMI and hip circumference, multiple regression analysis revealed a significant and independent association between waist circumference and total adiponectin levels. At follow up visceral fat loss was associated with a significant decrease in inflammatory markers and a non-significant increase in total adiponectin levels.
+
+ CONCLUSION: Increased visceral fat in overweight and obese subjects is associated with decreased total adiponectin levels. The health benefits of increasing adiponectin levels using different dietary intervention strategies need to be explored in larger studies.
+
+ TRIAL REGISTRATION: NCT01691365 , registered on 11/09/2012.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0386-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gariballa&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Total+adiponectin+in+overweight+and+obese+subjects+and+its+response+to+visceral+fat+loss.&volume=19&issue=1&spage=55&epage=&date=2019&doi=10.1186%2Fs12902-019-0386-z&pmid=31159801&sid=OVID:medline
+
+<1646>
+Unique Identifier
+ 31154828
+Title
+ Revisiting the obesity paradox in heart failure: Per cent body fat as predictor of biomarkers and outcome.
+Source
+ European Journal of Preventive Cardiology. 26(16):1751-1759, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aimo A; Januzzi JL Jr; Vergaro G; Clerico A; Latini R; Meessen J; Anand IS; Cohn JN; Gravning J; Ueland T; Nymo SH; Brunner-La Rocca HP; Bayes-Genis A; Lupon J; de Boer RA; Yoshihisa A; Takeishi Y; Egstrup M; Gustafsson I; Gaggin HK; Eggers KM; Huber K; Tentzeris I; Ripoli A; Passino C; Emdin M
+Authors Full Name
+ Aimo, Alberto; Januzzi, James L Jr; Vergaro, Giuseppe; Clerico, Aldo; Latini, Roberto; Meessen, Jennifer; Anand, Inder S; Cohn, Jay N; Gravning, Jorgen; Ueland, Thor; Nymo, Stale H; Brunner-La Rocca, Hans-Peter; Bayes-Genis, Antoni; Lupon, Josep; de Boer, Rudolf A; Yoshihisa, Akiomi; Takeishi, Yasuchika; Egstrup, Michael; Gustafsson, Ida; Gaggin, Hanna K; Eggers, Kai M; Huber, Kurt; Tentzeris, Ioannis; Ripoli, Andrea; Passino, Claudio; Emdin, Michele.
+Institution
+ Aimo, Alberto. Cardiology Division, University Hospital of Pisa, Italy.
+ Januzzi, James L Jr. Massachusetts General Hospital and Baim Institute for Clinical Research, Boston, USA.
+ Vergaro, Giuseppe. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
+ Vergaro, Giuseppe. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Clerico, Aldo. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
+ Clerico, Aldo. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Latini, Roberto. Department of Cardiovascular Research IRCCS - Istituto di Ricerche Farmacologiche - 'Mario Negri', Milan, Italy.
+ Meessen, Jennifer. Department of Cardiovascular Research IRCCS - Istituto di Ricerche Farmacologiche - 'Mario Negri', Milan, Italy.
+ Anand, Inder S. Division of Cardiovascular Medicine, University of Minnesota, Minneapolis, USA.
+ Anand, Inder S. Department of Cardiology, VA Medical Centre, Minneapolis, USA.
+ Cohn, Jay N. Division of Cardiovascular Medicine, University of Minnesota, Minneapolis, USA.
+ Gravning, Jorgen. Department of Cardiology, Oslo University Hospital, Ulleval, Oslo, Norway.
+ Gravning, Jorgen. Centre for Heart Failure Research, University of Oslo, Norway.
+ Ueland, Thor. Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Norway.
+ Ueland, Thor. Faculty of Medicine, University of Oslo, Norway.
+ Ueland, Thor. K. G. Jebsen Thrombosis Research and Expertise Centre, University of Tromso, Norway.
+ Nymo, Stale H. Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Norway.
+ Brunner-La Rocca, Hans-Peter. Department of Cardiology, Maastricht University Medical Centre, The Netherlands.
+ Bayes-Genis, Antoni. Hospital Universitari Germans Trias i Pujol, Badalona (Barcelona), Spain.
+ Lupon, Josep. Hospital Universitari Germans Trias i Pujol, Badalona (Barcelona), Spain.
+ de Boer, Rudolf A. University Medical Centre Groningen, The Netherlands.
+ Yoshihisa, Akiomi. Department of Cardiovascular Medicine, Fukushima Medical University, Japan.
+ Takeishi, Yasuchika. Department of Cardiovascular Medicine, Fukushima Medical University, Japan.
+ Egstrup, Michael. Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark.
+ Gustafsson, Ida. Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark.
+ Gaggin, Hanna K. Massachusetts General Hospital and Baim Institute for Clinical Research, Boston, USA.
+ Eggers, Kai M. Department of Medical Sciences, Cardiology, Uppsala University, Sweden.
+ Huber, Kurt. Faculty of Internal Medicine, Wilhelminenspital and Sigmund Freud University Medical School, Vienna, Austria.
+ Tentzeris, Ioannis. Faculty of Internal Medicine, Wilhelminenspital and Sigmund Freud University Medical School, Vienna, Austria.
+ Ripoli, Andrea. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Passino, Claudio. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
+ Passino, Claudio. Fondazione Toscana G. Monasterio, Pisa, Italy.
+ Emdin, Michele. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
+ Emdin, Michele. Fondazione Toscana G. Monasterio, Pisa, Italy.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Comorbidity
+ Female
+ Follow-Up Studies
+ Heart Failure/bl [Blood]
+ *Heart Failure/ep [Epidemiology]
+ Humans
+ Male
+ Middle Aged
+ *Natriuretic Peptide, Brain/bl [Blood]
+ Obesity/bl [Blood]
+ *Obesity/ep [Epidemiology]
+ *Peptide Fragments/bl [Blood]
+ Prognosis
+ Retrospective Studies
+ *Risk Assessment/mt [Methods]
+ Risk Factors
+ *Troponin T/bl [Blood]
+Keyword Heading
+ Obesity
+ heart failure
+ natriuretic peptides
+ prognosis
+ sST2
+ troponin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Obesity defined by body mass index (BMI) is characterized by better prognosis and lower plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure. We assessed whether another anthropometric measure, per cent body fat (PBF), reveals different associations with outcome and heart failure biomarkers (NT-proBNP, high-sensitivity troponin T (hs-TnT), soluble suppression of tumorigenesis-2 (sST2)).
+
+ METHODS: In an individual patient dataset, BMI was calculated as weight (kg)/height (m) 2 , and PBF through the Jackson-Pollock and Gallagher equations.
+
+ RESULTS: Out of 6468 patients (median 68 years, 78% men, 76% ischaemic heart failure, 90% reduced ejection fraction), 24% died over 2.2 years (1.5-2.9), 17% from cardiovascular death. Median PBF was 26.9% (22.4-33.0%) with the Jackson-Pollock equation, and 28.0% (23.8-33.5%) with the Gallagher equation, with an extremely strong correlation (r = 0.996, p < 0.001). Patients in the first PBF tertile had the worst prognosis, while patients in the second and third tertile had similar survival. The risks of all-cause and cardiovascular death decreased by up to 36% and 27%, respectively, per each doubling of PBF. Furthermore, prognosis was better in the second or third PBF tertiles than in the first tertile regardless of model variables. Both BMI and PBF were inverse predictors of NT-proBNP, but not hs-TnT. In obese patients (BMI >= 30 kg/m2, third PBF tertile), hs-TnT and sST2, but not NT-proBNP, independently predicted outcome.
+
+ CONCLUSION: In parallel with increasing BMI or PBF there is an improvement in patient prognosis and a decrease in NT-proBNP, but not hs-TnT or sST2. hs-TnT or sST2 are stronger predictors of outcome than NT-proBNP among obese patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (Troponin T). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1177%2f2047487319852809
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aimo&issn=2047-4873&title=European+Journal+of+Preventive+Cardiology&atitle=Revisiting+the+obesity+paradox+in+heart+failure%3A+Per+cent+body+fat+as+predictor+of+biomarkers+and+outcome.&volume=26&issue=16&spage=1751&epage=1759&date=2019&doi=10.1177%2F2047487319852809&pmid=31154828&sid=OVID:medline
+
+<1647>
+Unique Identifier
+ 31152776
+Title
+ Monocyte chemoattractant protein-1 (MCP-1) and fibroblast growth factor-21 (FGF-21) as biomarkers of subclinical atherosclerosis in women.
+Source
+ Experimental Gerontology. 124:110624, 2019 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Basurto L; Gregory MA; Hernandez SB; Sanchez-Huerta L; Martinez AD; Manuel-Apolinar L; Avelar FJ; Alonso LAM; Sanchez-Arenas R
+Authors Full Name
+ Basurto, Lourdes; Gregory, Michael A; Hernandez, Susana Barrera; Sanchez-Huerta, Lucero; Martinez, Alma Diaz; Manuel-Apolinar, Leticia; Avelar, Francisco J; Alonso, Laura Alejandra Mejia; Sanchez-Arenas, Rosalinda.
+Institution
+ Basurto, Lourdes. Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
+ Gregory, Michael A. School of Rehabilitation Sciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. Electronic address: gregom2@mcmaster.ca.
+ Hernandez, Susana Barrera. Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
+ Sanchez-Huerta, Lucero. Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
+ Martinez, Alma Diaz. Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
+ Manuel-Apolinar, Leticia. Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
+ Avelar, Francisco J. Departament of Radiology, Hospital de Especialidades, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico. Electronic address: francisco.avelar@imss.gob.mx.
+ Alonso, Laura Alejandra Mejia. Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
+ Sanchez-Arenas, Rosalinda. Research Unit in Epidemiology and Health Services, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico. Electronic address: felicitasarenas@gmail.com.
+MeSH Subject Headings
+ *Atherosclerosis/bl [Blood]
+ Atherosclerosis/dg [Diagnostic Imaging]
+ Biomarkers/bl [Blood]
+ Carotid Arteries/dg [Diagnostic Imaging]
+ Carotid Intima-Media Thickness
+ *Chemokine CCL2/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ *Fibroblast Growth Factors/bl [Blood]
+ Humans
+ Logistic Models
+ Mexico
+ Middle Aged
+ Obesity/co [Complications]
+ *Postmenopause/bl [Blood]
+ Risk Factors
+Keyword Heading
+ Atherosclerosis
+ Cardiovascular risk factor
+ Carotid IMT
+ FGF-21
+ MCP-1
+ Postmenopausal women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Atherosclerosis is a primary risk factor for cardiovascular disease (CVD). Proinflammatory biochemical factors can influence vascular health; monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with CVD while fibroblast growth factor-21 (FGF-21) acts directly on cardiac tissue to reduce infarction damage. However, the relationship between plasma concentrations of MCP-1, FGF-21 and subclinical CVD indices remains equivocal.
+
+ AIM: To determine the association between MCP-1, FGF-21 and subclinical atherosclerosis [i.e., carotid intima-media thickness (cIMT)] in women without clinical evidence of CVD.
+
+ METHODS: A cross-sectional analysis of 140 women without history of CVD was performed. Anthropometrics were collected, serum concentrations of MCP-1 and FGF-21 were determined by enzyme-linked immunosorbent assay, and cIMT was quantified (B-mode ultrasonography). The correlations between MCP-1, FGF-21 and the presence of clinical and laboratory of subclinical atherosclerosis (i.e., cIMT >=0.70mm), comparison intergroup and odd ratio with multiple logistic regression were analyzed.
+
+ RESULTS: MCP-1, but not FGF-21 correlated with some obesity indicators. In median comparison among groups, subclinical atherosclerosis showed higher serum concentrations of MCP-1and lower serum concentrations of FGF-21. In postmenopausal women, there were significant differences MCP-1 (p=0.001), and FGF-21 (p=0.010). Multiple logistic regression analysis in postmenopausal women with subclinical atherosclerosis, between MCP-1 (p=0.001) and FGF-21 (p=0.037) showed association with cIMT, along with age.
+
+ CONCLUSIONS: MCP-1 and FGF-21 levels are associated with subclinical atherosclerosis disease severity (i.e., cIMT) in postmenopausal women without CVD. Further efforts focused on characterizing the relationship between novel blood-borne markers of early CVD pathology are warranted and should be pursued. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Chemokine CCL2). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.exger.2019.05.013
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Basurto&issn=0531-5565&title=Experimental+Gerontology&atitle=Monocyte+chemoattractant+protein-1+%28MCP-1%29+and+fibroblast+growth+factor-21+%28FGF-21%29+as+biomarkers+of+subclinical+atherosclerosis+in+women.&volume=124&issue=&spage=110624&epage=&date=2019&doi=10.1016%2Fj.exger.2019.05.013&pmid=31152776&sid=OVID:medline
+
+<1648>
+Unique Identifier
+ 31150916
+Title
+ Brazil nut intake increases circulating miR-454-3p and miR-584-5p in obese women.
+Source
+ Nutrition Research. 67:40-52, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Reis BZ; Duarte GBS; Vargas-Mendez E; Ferreira LRP; Barbosa F Jr; Cercato C; Rogero MM; Cozzolino SMF
+Authors Full Name
+ Reis, Bruna Zavarize; Duarte, Graziela Biude Silva; Vargas-Mendez, Ernesto; Ferreira, Ludmila Rodrigues Pinto; Barbosa, Fernando Jr; Cercato, Cintia; Rogero, Marcelo Macedo; Cozzolino, Silvia Maria Franciscato.
+Institution
+ Reis, Bruna Zavarize. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: brunareis@usp.br.
+ Duarte, Graziela Biude Silva. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: gbiude@usp.br.
+ Vargas-Mendez, Ernesto. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: evargas@usp.br.
+ Ferreira, Ludmila Rodrigues Pinto. RNA Systems Biology Laboratory (RSBL), Department of Morphology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG). Electronic address: ludmila@icb.ufmg.br.
+ Barbosa, Fernando Jr. Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo. Electronic address: fbarbosa@fcfrp.usp.br.
+ Cercato, Cintia. Division of Endocrinology and Metabolism, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: ccercato@netpoint.com.br.
+ Rogero, Marcelo Macedo. Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, Research Innovation and Dissemination Centers Sao Paulo Research Foundation, Sao Paulo 05468-140, Brazil. Electronic address: mmrogero@usp.br.
+ Cozzolino, Silvia Maria Franciscato. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: smfcozzo@usp.br.
+MeSH Subject Headings
+ Adult
+ *Bertholletia/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Brazil
+ *Diet/mt [Methods]
+ Female
+ Humans
+ *MicroRNAs/bl [Blood]
+ *Nuts/me [Metabolism]
+ *Obesity/bl [Blood]
+ Obesity/me [Metabolism]
+Keyword Heading
+ Metabolic syndrome
+ MicroRNA, miR-375
+ Selenium
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The Brazil nut is an excellent source of selenium (Se), an essential micronutrient for human health. In this study, we hypothesized that Brazil nut intake modulates circulating microRNAs (miRNAs) in obese women and aimed to evaluate the effects of this nut intake on circulating miRNAs in women with obesity or metabolic syndrome (MetS). A randomized controlled clinical trial was conducted on 54 subjects recruited from the Clinical Hospital in Sao Paulo, Brazil. Patients were randomly assigned to 2 groups: a Brazil nut group (BN group, n=29) and a control group (CO group, n=25); both were monitored for 2months. BN group members were instructed to consume 1 Brazil nut (approximately 1261mug/Se) per day; CO group members were instructed not to consume any. Biochemical parameters related to Se status and 25 circulating miRNAs in plasma were evaluated in all patients both at baseline and after 2months. Expression levels of 2 miRNAs (miR-454-3p and miR-584-5p) were significantly increased after Brazil nut intake. To investigate the effect of MetS on circulating miRNAs at baseline, we performed comparisons between women with MetS (n=23) and women without MetS (others, n=31). Circulating miR-375 levels were significantly lower (P=.012) in women with MetS. In conclusion, our findings suggested that a daily intake of 1 Brazil nut increased circulating miR-454-3p and miR-584-5p expression levels in obese women, and our network analysis indicated a link between Se intake, vitamin D metabolism, and calcium homeostasis. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN454 microRNA, human). 0 (MIRN584 microRNA, human). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.nutres.2019.05.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Reis&issn=0271-5317&title=Nutrition+Research&atitle=Brazil+nut+intake+increases+circulating+miR-454-3p+and+miR-584-5p+in+obese+women.&volume=67&issue=&spage=40&epage=52&date=2019&doi=10.1016%2Fj.nutres.2019.05.004&pmid=31150916&sid=OVID:medline
+
+<1649>
+Unique Identifier
+ 31150359
+Title
+ The metabolic consequences of overweight in a cohort of children with type 1 diabetes.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 32(7):715-719, 2019 Jul 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sevaliev N; Strich D; Avnon-Ziv C; Levy-Khademi F
+Authors Full Name
+ Sevaliev, Natalia; Strich, David; Avnon-Ziv, Carmit; Levy-Khademi, Floris.
+Institution
+ Sevaliev, Natalia. The Faculty of Medicine, Hebrew University, Jerusalem, Israel.
+ Strich, David. Diabetes Clinic at Clalit Health Organization, Jerusalem, Israel.
+ Avnon-Ziv, Carmit. Division of Pediatric Endocrinology, Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem Israel.
+ Levy-Khademi, Floris. Division of Pediatric Endocrinology, Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem Israel.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Case-Control Studies
+ Child
+ Child, Preschool
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 1/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Israel/ep [Epidemiology]
+ Male
+ *Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/me [Metabolism]
+ *Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ *Overweight/ep [Epidemiology]
+ Overweight/me [Metabolism]
+ Prevalence
+ Prognosis
+ Waist Circumference
+ Waist-Hip Ratio
+ Young Adult
+Keyword Heading
+ children
+ dyslipidemia
+ hypertension
+ metabolic derangements
+ obesity
+ type 1 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective To estimate the prevalence of overweight and obesity among a cohort of children with type 1 diabetes mellitus (T1DM) and its metabolic consequences. Methods This was a cross-sectional study conducted in the Pediatric Diabetic Clinic at Shaare Zedek Medical Center and Clalit Health Care Services. Background information was taken from the patients' files. Anthropometric measures, blood pressure, waist and hip circumference (WC and HC), hemoglobin A1c (HbA1c) and lipid profile were recorded. The prevalence of metabolic derangements was compared between normal and overweight children. Results The study included 96 patients with type 1 diabetes, mean age 14.1 +/- 3.7 years, mean diabetes duration 3.9 +/- 3 and mean HbA1c level 8.1 +/- 1.4% (65 mmol/mol). Thirty-seven percent of the study population were overweight and of them 11.5% were obese. In the overweight group, the high-density lipoprotein (HDL) levels were significantly lower and systolic blood pressure (SBP) and diastolic blood pressure (DBP) values were higher compared with normal weight participants. Multivariate analysis showed that BMI and age at study affected SBP and HDL levels, while age at study and HbA1c levels affected DBP. Female patients were significantly overweight compared to males and had higher low-density lipoprotein (LDL) and cholesterol levels. Waist-to-hip ratio, an indicator of central obesity, was abnormally high among overweight males and females. Conclusions In our cohort of children with type 1 diabetes, there were a significant number of overweight children, with a higher prevalence in females. Components of metabolic syndrome were more prevalent among overweight and obese diabetic individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fjpem-2018-0483
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sevaliev&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=The+metabolic+consequences+of+overweight+in+a+cohort+of+children+with+type+1+diabetes.&volume=32&issue=7&spage=715&epage=719&date=2019&doi=10.1515%2Fjpem-2018-0483&pmid=31150359&sid=OVID:medline
+
+<1650>
+Unique Identifier
+ 31144432
+Title
+ Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED-Plus trial.
+Source
+ Journal of Cachexia, Sarcopenia and Muscle. 10(5):974-984, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abete I; Konieczna J; Zulet MA; Galmes-Panades AM; Ibero-Baraibar I; Babio N; Estruch R; Vidal J; Toledo E; Razquin C; Bartolome R; Diaz-Lopez A; Fiol M; Casas R; Vera J; Buil-Cosiales P; Pinto X; Corbella E; Portillo MP; de Paz JA; Martin V; Daimiel L; Goday A; Rosique-Esteban N; Salas-Salvado J; Romaguera D; Martinez JA
+Author NameID
+ Konieczna, Jadwiga; ORCID: https://orcid.org/0000-0002-2947-1338
+ Zulet, M Angeles; ORCID: https://orcid.org/0000-0002-3926-0892
+Corporate Author
+ PREDIMED-PLUS Investigators
+Authors Full Name
+ Abete, Itziar; Konieczna, Jadwiga; Zulet, M Angeles; Galmes-Panades, Aina M; Ibero-Baraibar, Idoia; Babio, Nancy; Estruch, Ramon; Vidal, Josep; Toledo, Estefania; Razquin, Cristina; Bartolome, Rafael; Diaz-Lopez, Andres; Fiol, Miquel; Casas, Rosa; Vera, Josep; Buil-Cosiales, Pilar; Pinto, Xavier; Corbella, Emili; Portillo, Maria Puy; de Paz, Jose Antonio; Martin, Vicente; Daimiel, Lidia; Goday, Albert; Rosique-Esteban, Nuria; Salas-Salvado, Jordi; Romaguera, Dora; Martinez, J Alfredo.
+Institution
+ Abete, Itziar. Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, University of Navarra (UNAV), Pamplona, Spain.
+ Abete, Itziar. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Abete, Itziar. IdiSNA (Instituto de Investigacion Sanitaria de Navarra), Pamplona, Spain.
+ Konieczna, Jadwiga. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Konieczna, Jadwiga. Instituto de Investigacion Sanitaria Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.
+ Zulet, M Angeles. Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, University of Navarra (UNAV), Pamplona, Spain.
+ Zulet, M Angeles. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Zulet, M Angeles. IdiSNA (Instituto de Investigacion Sanitaria de Navarra), Pamplona, Spain.
+ Galmes-Panades, Aina M. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Galmes-Panades, Aina M. Instituto de Investigacion Sanitaria Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.
+ Ibero-Baraibar, Idoia. Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, University of Navarra (UNAV), Pamplona, Spain.
+ Babio, Nancy. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Babio, Nancy. Department of Biochemistry and Biotechnology, Human Nutrition Unit, IISPV, Rovira i Virgili University, Hospital Universitari Sant Joan de Reus, Reus, Spain.
+ Estruch, Ramon. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Estruch, Ramon. Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
+ Vidal, Josep. Department of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
+ Vidal, Josep. CIBER Diabetes y enfermedades metabolicas (CIBERdem), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Toledo, Estefania. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Toledo, Estefania. IdiSNA (Instituto de Investigacion Sanitaria de Navarra), Pamplona, Spain.
+ Toledo, Estefania. Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
+ Razquin, Cristina. IdiSNA (Instituto de Investigacion Sanitaria de Navarra), Pamplona, Spain.
+ Razquin, Cristina. Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
+ Bartolome, Rafael. Atencion Primaria, Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain.
+ Diaz-Lopez, Andres. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Diaz-Lopez, Andres. Department of Biochemistry and Biotechnology, Human Nutrition Unit, IISPV, Rovira i Virgili University, Hospital Universitari Sant Joan de Reus, Reus, Spain.
+ Fiol, Miquel. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Fiol, Miquel. Instituto de Investigacion Sanitaria Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.
+ Casas, Rosa. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Casas, Rosa. Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
+ Vera, Josep. Institut Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
+ Buil-Cosiales, Pilar. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Buil-Cosiales, Pilar. IdiSNA (Instituto de Investigacion Sanitaria de Navarra), Pamplona, Spain.
+ Buil-Cosiales, Pilar. Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
+ Buil-Cosiales, Pilar. Atencion Primaria, Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain.
+ Pinto, Xavier. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Pinto, Xavier. Vascular Risk Unit, Internal Medicine Department, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
+ Corbella, Emili. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Corbella, Emili. Vascular Risk Unit, Internal Medicine Department, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
+ Portillo, Maria Puy. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Portillo, Maria Puy. Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, Vitoria, Spain.
+ de Paz, Jose Antonio. Instituto de Biomedicina (IBIOMED), University of Leon, Leon, Spain.
+ Martin, Vicente. Division of Preventive Medicine, University of Leon, Leon, Spain.
+ Martin, Vicente. CIBER Epidemiologia y Salud Publica (CIBEResp), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Daimiel, Lidia. Madrid Institute for Advanced Studies (IMDEA), Food Institute, Madrid, Spain.
+ Goday, Albert. Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d'Investigacio Medica (IMIM), Endocrinology and Diabetes Unit, Department de Medicina, Hospital del Mar Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain.
+ Rosique-Esteban, Nuria. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Rosique-Esteban, Nuria. Department of Biochemistry and Biotechnology, Human Nutrition Unit, IISPV, Rovira i Virgili University, Hospital Universitari Sant Joan de Reus, Reus, Spain.
+ Salas-Salvado, Jordi. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Salas-Salvado, Jordi. Department of Biochemistry and Biotechnology, Human Nutrition Unit, IISPV, Rovira i Virgili University, Hospital Universitari Sant Joan de Reus, Reus, Spain.
+ Romaguera, Dora. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Romaguera, Dora. Instituto de Investigacion Sanitaria Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.
+ Martinez, J Alfredo. Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, University of Navarra (UNAV), Pamplona, Spain.
+ Martinez, J Alfredo. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
+ Martinez, J Alfredo. IdiSNA (Instituto de Investigacion Sanitaria de Navarra), Pamplona, Spain.
+ Martinez, J Alfredo. Madrid Institute for Advanced Studies (IMDEA), Food Institute, Madrid, Spain.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Aged
+ Biomarkers
+ Body Composition
+ Cross-Sectional Studies
+ Disease Susceptibility
+ Female
+ Humans
+ *Inflammation/co [Complications]
+ Inflammation/me [Metabolism]
+ *Life Style
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ *Obesity/et [Etiology]
+ Randomized Controlled Trials as Topic
+ Sarcopenia/di [Diagnosis]
+ *Sarcopenia/ep [Epidemiology]
+ *Sarcopenia/et [Etiology]
+ Socioeconomic Factors
+Keyword Heading
+ Leucocyte count
+ Mediterranean diet score
+ Physical activity
+ Sarcopenic index
+ Systemic inflammation
+ Visceral fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to 'sarcopenic obesity'. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity.
+
+ METHODS: A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 +/- 3.3 kg/m2 ; age: 65.2 +/- 4.9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables.
+
+ RESULTS: Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0.05), PA (P-trend < 0.0001), and the 30 s chair stand test (P-trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P-trend < 0.05), visceral fat and leucocyte count (all P-trend < 0.0001), and some white cell subtypes (neutrophils and monocytes), neutrophil-to-lymphocyte ratio, and platelet count (all P-trend < 0.05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance.
+
+ CONCLUSIONS: Diet and PA are important regulatory mediators of systemic inflammation, which is directly involved in the sarcopenic process. A healthy dietary pattern combined with exercise is a promising strategy to limit age-related sarcopenia. Copyright © 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fjcsm.12442
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abete&issn=2190-5991&title=Journal+of+Cachexia%2C+Sarcopenia+and+Muscle&atitle=Association+of+lifestyle+factors+and+inflammation+with+sarcopenic+obesity%3A+data+from+the+PREDIMED-Plus+trial.&volume=10&issue=5&spage=974&epage=984&date=2019&doi=10.1002%2Fjcsm.12442&pmid=31144432&sid=OVID:medline
+
+<1651>
+Unique Identifier
+ 31144161
+Title
+ Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats.
+Source
+ Chinese Journal of Integrative Medicine. 25(12):895-901, 2019 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Park HJ; Kim JH; Shim I
+Authors Full Name
+ Park, Hyun-Jung; Kim, Ji Hyun; Shim, Insop.
+Institution
+ Park, Hyun-Jung. Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
+ Park, Hyun-Jung. Department of Food Science & Biotechnology, College of Science and Engineering, Suwon-si, 16227, Republic of Korea.
+ Kim, Ji Hyun. Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
+ Shim, Insop. Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea. ishim@khu.ac.kr.
+MeSH Subject Headings
+ Adipose Tissue/de [Drug Effects]
+ Animals
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ *Diet, High-Fat
+ Disease Models, Animal
+ *Ginsenosides/pd [Pharmacology]
+ Locomotion/de [Drug Effects]
+ *Obesity/dt [Drug Therapy]
+ *Panax
+ Rats
+ Rats, Sprague-Dawley
+Keyword Heading
+ Panax ginseng
+ ginsenosides
+ hypothalamus
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng (KRG, Panax ginseng) in rats fed with a high-fat diet (HFD).
+
+ METHODS: Twenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks; subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re (10 mg/kg, intraperitoneal injection) for a further 3 weeks (n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide (NO) expression, leptin, neuropeptide Y (NPY), cholecystokinin (CCK) in the brains were measured.
+
+ RESULTS: In the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats (P<0.05 or P<0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight (P<0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group (P<0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group (P<0.05).
+
+ CONCLUSION: PD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Ginsenosides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11655-019-3200-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Park&issn=1672-0415&title=Chinese+Journal+of+Integrative+Medicine&atitle=Anti-obesity+Effects+of+Ginsenosides+in+High-Fat+Diet-Fed+Rats.&volume=25&issue=12&spage=895&epage=901&date=2019&doi=10.1007%2Fs11655-019-3200-x&pmid=31144161&sid=OVID:medline
+
+<1652>
+Unique Identifier
+ 31141980
+Title
+ Cardiovascular Risk Factors and Their Association with Vitamin D Deficiency in Mexican Women of Reproductive Age.
+Source
+ Nutrients. 11(6), 2019 May 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Contreras-Manzano A; Villalpando S; Garcia-Diaz C; Flores-Aldana M
+Author NameID
+ Contreras-Manzano, Alejandra; ORCID: https://orcid.org/0000-0003-1576-5922
+ Villalpando, Salvador; ORCID: https://orcid.org/0000-0001-6429-3816
+ Flores-Aldana, Mario; ORCID: https://orcid.org/0000-0001-5522-6849
+Authors Full Name
+ Contreras-Manzano, Alejandra; Villalpando, Salvador; Garcia-Diaz, Claudia; Flores-Aldana, Mario.
+Institution
+ Contreras-Manzano, Alejandra. Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca 62100, Mexico. alejandra.contreras@insp.mx.
+ Villalpando, Salvador. Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca 62100, Mexico. svillalp@insp.mx.
+ Garcia-Diaz, Claudia. Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca 62100, Mexico. clauw.g.diaz@gmail.com.
+ Flores-Aldana, Mario. Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca 62100, Mexico. mario.flores@insp.mx.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/ep [Epidemiology]
+ Female
+ Humans
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Mexico/ep [Epidemiology]
+ Middle Aged
+ Nutrition Surveys
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ *Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/di [Diagnosis]
+ *Vitamin D Deficiency/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ 25-OH-D
+ T2DM
+ cardiovascular risk factors
+ obesity
+ vitamin D deficiency
+ women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Based on a nationally representative sample of young Mexican women aged 20 to 49 years (n = 3260), we sought to explore whether cardiovascular risk factors and acute myocardial infarction (AMI) were associated with vitamin D deficiency (VDD, defined as 25-OH-D <50 nmol/L). To this end, we obtained sociodemographic, serum and anthropometric data from the 2012 National Health and Nutrition Survey (ENSANUT 2012). Analyses were developed through logistic regression models adjusted for potential confounders. The prevalence of VDD was significantly higher in obese women (42.5%, 95% CI; 37.3-47.9) compared to women with a normal body mass index (29.9%, 95% CI; 23.5-37.1, p = 0.05), in those with high total cholesterol (TC) (45.6% 95% CI; 39.4-51.9) compared to those with normal TC levels (33.9%, 95% CI 30-38.1, p = 0.03), and in those with insulin resistance (IR) (44%, 95% CI; 36.9-51.7) or type 2 diabetes mellitus (T2DM) (58.6%, 95% CI 46.9-69.4) compared to those with normal glycemia (no insulin resistance: 34.7%, 95% CI; 30.9-38.8, p = 0.04 and no T2DM: 34.9%, 95% CI 31.4-38.6, p < 0.001). Utilizing individual models to estimate cardiovascular risk according to VDD, we found that the odds of being obese (odds ratio, OR: 1.53, 95% CI 1.02-2.32, p = 0.05), or having high TC levels (OR: 1.43, 95% CI; 1.05-2.01, p = 0.03), T2DM (OR: 2.64, 95% CI; 1.65-4.03, p < 0.001), or IR (OR: 1.48, 95% CI 1.04-2.10, p = 0.026) were significantly higher in women with VDD (p < 0.05). Odds were not statistically significant for overweight, high blood pressure, sedentarism, AMI, high serum concentration of triglycerides, homocysteine, or C-reactive protein models. In conclusion, our results indicate that young Mexican women with VDD show a higher prevalence of cardiovascular risk factors.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). 1406-16-2 (Vitamin D). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11061211
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Contreras-Manzano&issn=2072-6643&title=Nutrients&atitle=Cardiovascular+Risk+Factors+and+Their+Association+with+Vitamin+D+Deficiency+in+Mexican+Women+of+Reproductive+Age.&volume=11&issue=6&spage=&epage=&date=2019&doi=10.3390%2Fnu11061211&pmid=31141980&sid=OVID:medline
+
+<1653>
+Unique Identifier
+ 31141900
+Title
+ Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats.
+Source
+ Nutrients. 11(6), 2019 May 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Melo BF; Sacramento JF; Ribeiro MJ; Prego CS; Correia MC; Coelho JC; Cunha-Guimaraes JP; Rodrigues T; Martins IB; Guarino MP; Seica RM; Matafome P; Conde SV
+Authors Full Name
+ Melo, Bernardete F; Sacramento, Joana F; Ribeiro, Maria J; Prego, Claudia S; Correia, Miguel C; Coelho, Joana C; Cunha-Guimaraes, Joao P; Rodrigues, Tiago; Martins, Ines B; Guarino, Maria P; Seica, Raquel M; Matafome, Paulo; Conde, Silvia V.
+Institution
+ Melo, Bernardete F. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. Bernardete.melo@nms.unl.pt.
+ Sacramento, Joana F. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. joana.sacramento@nms.unl.pt.
+ Ribeiro, Maria J. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. mj.rfribeiro@gmail.com.
+ Prego, Claudia S. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. claudia.prego@nms.unl.pt.
+ Correia, Miguel C. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. mc.correia@campus.fct.unl.pt.
+ Coelho, Joana C. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. joana.indias@gmail.com.
+ Cunha-Guimaraes, Joao P. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. jp.guimaraes@campus.fct.unl.pt.
+ Rodrigues, Tiago. Instituto de Investigacao Clinica e Biomedica de Coimbra (iCBR), Faculdade de Medicina de Coimbra, 3000-548 Coimbra, Portugal. tiagodarodrigues@gmail.com.
+ Martins, Ines B. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. iib.martins@campus.fct.unl.pt.
+ Guarino, Maria P. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. maria.guarino@ioleiria.pt.
+ Guarino, Maria P. Escola Superior de Saude de Leiria- Instituto Politecnico de Leiria, 2410-197 Leiria, Portugal. maria.guarino@ioleiria.pt.
+ Seica, Raquel M. Instituto de Investigacao Clinica e Biomedica de Coimbra (iCBR), Faculdade de Medicina de Coimbra, 3000-548 Coimbra, Portugal. rmfseica@gmail.com.
+ Matafome, Paulo. Instituto de Investigacao Clinica e Biomedica de Coimbra (iCBR), Faculdade de Medicina de Coimbra, 3000-548 Coimbra, Portugal. paulomatafome@gmail.com.
+ Matafome, Paulo. Instituto Politecnico de Coimbra, Coimbra Health School (ESTeSC), Department of Complementary Sciences, 3046-854 Coimbra, Portugal. paulomatafome@gmail.com.
+ Conde, Silvia V. CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, 1150-082 Lisboa, Portugal. silvia.conde@nms.unl.pt.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pp [Physiopathology]
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure
+ Diabetes Mellitus, Experimental/bl [Blood]
+ *Diabetes Mellitus, Experimental/et [Etiology]
+ Diabetes Mellitus, Experimental/pp [Physiopathology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ *Diet, High-Fat
+ *Dietary Sucrose
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/et [Etiology]
+ Dyslipidemias/pp [Physiopathology]
+ Energy Intake
+ Glucose Intolerance/bl [Blood]
+ *Glucose Intolerance/et [Etiology]
+ Glucose Intolerance/pp [Physiopathology]
+ Hypertension/et [Etiology]
+ Hypertension/pp [Physiopathology]
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/bl [Blood]
+ *Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ Phenotype
+ Rats, Wistar
+ Rats, Zucker
+ *Weight Gain
+Keyword Heading
+ adipose tissue
+ animal models
+ glucose tolerance
+ hypertension
+ insulin sensitivity
+ metabolic syndrome
+ obesity
+ type 2 diabetes
+ weight gain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Animal experimentation has a long history in the study of metabolic syndrome-related disorders. However, no consensus exists on the best models to study these syndromes. Knowing that different diets can precipitate different metabolic disease phenotypes, herein we characterized several hypercaloric rat models of obesity and type 2 diabetes, comparing each with a genetic model, with the aim of identifying the most appropriate model of metabolic disease. The effect of hypercaloric diets (high fat (HF), high sucrose (HSu), high fat plus high sucrose (HFHSu) and high fat plus streptozotocin (HF+STZ) during different exposure times (HF 3 weeks, HF 19 weeks, HSu 4 weeks, HSu 16 weeks, HFHSu 25 weeks, HF3 weeks + STZ) were compared with the Zucker fatty rat. Each model was evaluated for weight gain, fat mass, fasting plasma glucose, insulin and C-peptide, insulin sensitivity, glucose tolerance, lipid profile and liver lipid deposition, blood pressure, and autonomic nervous system function. All animal models presented with insulin resistance and dyslipidemia except the HF+STZ and HSu 4 weeks, which argues against the use of these models as metabolic syndrome models. Of the remaining animal models, a higher weight gain was exhibited by the Zucker fatty rat and wild type rats submitted to a HF diet for 19 weeks. We conclude that the latter model presents a phenotype most consistent with that observed in humans with metabolic disease, exhibiting the majority of the phenotypic features and comorbidities associated with type 2 diabetes in humans.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Sucrose). 0 (Insulin). 0 (Lipids).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11061197
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Melo&issn=2072-6643&title=Nutrients&atitle=Evaluating+the+Impact+of+Different+Hypercaloric+Diets+on+Weight+Gain%2C+Insulin+Resistance%2C+Glucose+Intolerance%2C+and+its+Comorbidities+in+Rats.&volume=11&issue=6&spage=&epage=&date=2019&doi=10.3390%2Fnu11061197&pmid=31141900&sid=OVID:medline
+
+<1654>
+Unique Identifier
+ 31141526
+Title
+ Maternal pre-pregnancy weight status modifies the influence of PUFAs and inflammatory biomarkers in breastmilk on infant growth.
+Source
+ PLoS ONE [Electronic Resource]. 14(5):e0217085, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nuss H; Altazan A; Zabaleta J; Sothern M; Redman L
+Author NameID
+ Nuss, Henry; ORCID: https://orcid.org/0000-0002-1073-3262
+Authors Full Name
+ Nuss, Henry; Altazan, Abby; Zabaleta, Jovanny; Sothern, Melinda; Redman, Leanne.
+Institution
+ Nuss, Henry. Behavioral and Community Health Sciences, School of Public Health, Louisiana State University Health, New Orleans, Louisiana.
+ Altazan, Abby. Pennington Biomedical Research Center, Baton Rouge, Louisiana.
+ Zabaleta, Jovanny. Department of Pediatrics, School of Medicine, Louisiana State University Health, New Orleans, Louisiana.
+ Sothern, Melinda. Behavioral and Community Health Sciences, School of Public Health, Louisiana State University Health, New Orleans, Louisiana.
+ Sothern, Melinda. Pennington Biomedical Research Center, Baton Rouge, Louisiana.
+ Sothern, Melinda. Department of Pediatrics, School of Medicine, Louisiana State University Health, New Orleans, Louisiana.
+ Redman, Leanne. Pennington Biomedical Research Center, Baton Rouge, Louisiana.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Birth Weight
+ Body Mass Index
+ *Body Weight
+ *Child Development
+ *Fatty Acids, Unsaturated/bl [Blood]
+ Female
+ Humans
+ Infant
+ Infant, Newborn
+ *Inflammation/pp [Physiopathology]
+ *Inflammation Mediators/bl [Blood]
+ Male
+ *Milk, Human/ch [Chemistry]
+ Obesity/pp [Physiopathology]
+ Pilot Projects
+ Pregnancy
+ Prospective Studies
+ Young Adult
+Abstract
+ BACKGROUND: Human breastmilk contains pro- and anti-inflammatory compounds and hormones that can influence infant growth. However, little is known about the specific interrelationships between these compounds and whether their effects on infant growth may be influenced by pre-pregnancy weight status.
+
+ OBJECTIVE: The purpose of this novel, prospective cohort study was to assess the interrelationships between pro-inflammatory cytokines (TNF-alpha, IL-6), hormones (insulin, leptin) and PUFAs (n-6, n-3) in blood and breastmilk in early postpartum between women with normal BMI (Group 1, n = 18; 18.5=25.0 kg/m2) before pregnancy to determine if these components correlated to infant growth measures at age 4-8 weeks.
+
+ METHODS: Participants were robustly phenotyped along with their infants at 4-8 weeks postpartum. TNF-alpha, IL-6, insulin, leptin, and n-3 and n-6 PUFAs measured in blood and breastmilk and compared between pre-pregnancy BMI groups and with infant weight, length, head circumference and % fat mass.
+
+ RESULTS: Group 1 women had higher serum leptin (p<0.01) and breastmilk leptin (p<0.001) compared to Group 2. Other inflammatory markers, hormones, and total n-6, n-3 and n-6/n-3 ratio PUFAs were similar between pre-pregnancy BMI groups. No relationships were observed between whey inflammatory markers, hormones, PUFAs and growth measures in infants born to Group 2 women. However, TNF-alpha was positively related and, IL-6, leptin, insulin, total n-6, n-3 and n-6/n-3 PUFAs in whey breastmilk were negatively correlated to infant growth measures in infants born to Group 1 women (p<0.01).
+
+ CONCLUSIONS: Pro-inflammatory qualities of breastmilk were associated with infant growth measures regardless of maternal pre-pregnancy BMI. However, infants born to women with overweight or obesity demonstrated less responsive growth to breastmilk contents. More studies are needed to assess longitudinal effects of this impact.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Unsaturated). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural. Research Support, U.S. Gov't, P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0217085
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nuss&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Maternal+pre-pregnancy+weight+status+modifies+the+influence+of+PUFAs+and+inflammatory+biomarkers+in+breastmilk+on+infant+growth.&volume=14&issue=5&spage=e0217085&epage=&date=2019&doi=10.1371%2Fjournal.pone.0217085&pmid=31141526&sid=OVID:medline
+
+<1655>
+Unique Identifier
+ 31141297
+Title
+ Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient.
+Source
+ Journal Of Diabetes. 11(12):982-992, 2019 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li W; Liu R; Li X; Tao B; Zhai N; Wang X; Li Q; Zhang Y; Gu W; Wang W; Ning G
+Author NameID
+ Gu, Weiqiong; ORCID: https://orcid.org/0000-0002-3296-3384
+Authors Full Name
+ Li, Wen; Liu, Ruixin; Li, Xuelin; Tao, Bei; Zhai, Nan; Wang, Xiaolin; Li, Qi; Zhang, Yifei; Gu, Weiqiong; Wang, Weiqing; Ning, Guang.
+Institution
+ Li, Wen. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Liu, Ruixin. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Li, Xuelin. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Tao, Bei. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Zhai, Nan. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Wang, Xiaolin. Chinese Academy of Sciences Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian, China.
+ Li, Qi. Chinese Academy of Sciences Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian, China.
+ Zhang, Yifei. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Gu, Weiqiong. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Wang, Weiqing. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Ning, Guang. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumours, Shanghai Clinical Centre for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai Institute for Endocrinology, Shanghai, China.
+ Ning, Guang. Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+MeSH Subject Headings
+ Adamantane/ae [Adverse Effects]
+ *Adamantane/aa [Analogs & Derivatives]
+ Adamantane/tu [Therapeutic Use]
+ Adult
+ *Bile Acids and Salts/bl [Blood]
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ China
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Dipeptides/ae [Adverse Effects]
+ *Dipeptides/tu [Therapeutic Use]
+ Dipeptidyl-Peptidase IV Inhibitors/ae [Adverse Effects]
+ *Dipeptidyl-Peptidase IV Inhibitors/tu [Therapeutic Use]
+ *Energy Metabolism/de [Drug Effects]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ 2
+ bile acids
+ dipeptidyl peptidase-4 inhibitor
+ obesity
+ saxagliptin
+ type 2 diabetes
+ -4
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The aim of the present study was to investigate the metabolic benefits of saxagliptin and its effects on serum bile acids (BAs) in normal weight and overweight/obese drug-naive type 2 diabetes (T2D) patients.
+
+ METHODS: In all, 282 drug-naive T2D patients (123 normal weight [NW], with body mass index [BMI] between 19.0 and <25.0 kg/m2 ; 159 overweight/obese [OW/OB], with BMI >=25.0 kg/m2 ) were enrolled in the study and treated with saxagliptin 5 mg daily for 24 weeks. Serum BAs were assayed by liquid chromatography with tandem mass spectrometry.
+
+ RESULTS: At 24 weeks, HbA1c was significantly reduced in both groups, but the HbA1c levels were lower in the OW/OB than NW group. Moreover, significant decreases were seen at 24 weeks in C-reactive protein (CRP), aspartate aminotransferase, alanine aminotransferase, waist circumference, and systolic blood pressure in the OW/OB group. Interestingly, cholic acid, glycocholic acid, glycochenodeoxycholic acid, glycodeoxycholic acid (GDCA), and glycoursodeoxycholic acid (GUDCA) were increased in both groups after treatment, whereas chenodeoxycholic acid and deoxycholic acid (DCA) were specifically increased in the OW/OB group. Increased DCA and GDCA concentrations were significantly associated with decreased HbA1c or fasting blood glucose and CRP levels, whereas increased GDCA and GUDCA concentrations were associated with decreased waist circumference in the OW/OB group during treatment. In the NW group, increased GUDCA concentrations were significantly associated with a decrease in HbA1c.
+
+ CONCLUSIONS: Type 2 diabetes patients with OW/OB exhibited greater improvement in glycemic control and additional metabolic benefits after saxagliptin treatment. Saxagliptin significantly increased the BA pool, and DCA and GDCA were associated with metabolic improvements in OW/OB T2D patients. Copyright © 2019 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
+Other Abstract
+ Publisher
+ : / 2 , : 282 2 , (body mass index, BMI) (NW, 19.0=25.0 kg/m2 , n=159), 24 , 5 mg , - : 24 , (HbA1c) , OW/OB HbA1c NW , OW/OB C- (CRP) (CA) (GCA) (GCDCA) (GDCA) (GUDCA) 24 , (CDCA) (DCA) OW/OB , OW/OB DCA GDCA CRP , GDCA GUDCA NW GUDCA HbA1c : / 2 , DCA GDCA / 2 .
+ Language: Chinese
+Registry Number/Name of Substance
+ 0 (Bile Acids and Salts). 0 (Biomarkers). 0 (Blood Glucose). 0 (Dipeptides). 0 (Dipeptidyl-Peptidase IV Inhibitors). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human). 9GB927LAJW (saxagliptin). PJY633525U (Adamantane).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2f1753-0407.12956
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=1753-0407&title=Journal+Of+Diabetes&atitle=Saxagliptin+alters+bile+acid+profiles+and+yields+metabolic+benefits+in+drug-naive+overweight+or+obese+type+2+diabetes+patient.&volume=11&issue=12&spage=982&epage=992&date=2019&doi=10.1111%2F1753-0407.12956&pmid=31141297&sid=OVID:medline
+
+<1656>
+Unique Identifier
+ 31138500
+Title
+ The role of inflammation in the association between overall and visceral adiposity and subclinical atherosclerosis.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 29(7):728-735, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Christen T; Trompet S; Rensen PCN; Willems van Dijk K; Lamb HJ; Jukema JW; Rosendaal FR; le Cessie S; de Mutsert R
+Authors Full Name
+ Christen, T; Trompet, S; Rensen, P C N; Willems van Dijk, K; Lamb, H J; Jukema, J W; Rosendaal, F R; le Cessie, S; de Mutsert, R.
+Institution
+ Christen, T. Department of Clinical Epidemiology, Leiden University Medical Center (LUMC), PO Box 9600, 2300, RC, Leiden, the Netherlands. Electronic address: t.christen@lumc.nl.
+ Trompet, S. Department of Medicine, Division of Gerontology and Geriatrics, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands.
+ Rensen, P C N. Department of Medicine, Division of Endocrinology, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands.
+ Willems van Dijk, K. Department of Medicine, Division of Endocrinology, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands; Department of Human Genetics, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands.
+ Lamb, H J. Department of Radiology, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands.
+ Jukema, J W. Department of Cardiology, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands.
+ Rosendaal, F R. Department of Clinical Epidemiology, Leiden University Medical Center (LUMC), PO Box 9600, 2300, RC, Leiden, the Netherlands.
+ le Cessie, S. Department of Clinical Epidemiology, Leiden University Medical Center (LUMC), PO Box 9600, 2300, RC, Leiden, the Netherlands; Department of Biomedical Data Sciences, LUMC, PO Box 9600, 2300, RC, Leiden, the Netherlands.
+ de Mutsert, R. Department of Clinical Epidemiology, Leiden University Medical Center (LUMC), PO Box 9600, 2300, RC, Leiden, the Netherlands.
+MeSH Subject Headings
+ *Adiposity
+ Asymptomatic Diseases
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ *Carotid Artery Diseases/bl [Blood]
+ Carotid Artery Diseases/dg [Diagnostic Imaging]
+ Carotid Artery Diseases/ep [Epidemiology]
+ Carotid Intima-Media Thickness
+ Cross-Sectional Studies
+ Electric Impedance
+ Female
+ Glycoproteins/bl [Blood]
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/di [Diagnosis]
+ Inflammation/ep [Epidemiology]
+ *Inflammation Mediators/bl [Blood]
+ Intra-Abdominal Fat/dg [Diagnostic Imaging]
+ *Intra-Abdominal Fat/pp [Physiopathology]
+ Magnetic Resonance Imaging
+ Male
+ Middle Aged
+ Netherlands/ep [Epidemiology]
+ Obesity/dg [Diagnostic Imaging]
+ Obesity/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ Risk Factors
+Keyword Heading
+ Atherosclerosis
+ C-reactive protein
+ Inflammation
+ Mediation
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Inflammation may underlie the association between obesity, atherosclerosis and cardiovascular disease. We investigated to what extent markers of inflammation mediate associations between overall and visceral body fat and subclinical atherosclerosis.
+
+ METHODS AND RESULTS: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study we estimated total body fat (TBF) by bio-impedance analysis, carotid artery intima media thickness (cIMT) by ultrasound, C-reactive protein (hs-CRP) and glycoprotein acetyls (GlycA) concentrations in fasting blood samples (n = 5627), and visceral adipose tissue (VAT) by magnetic resonance imaging (n = 2247). We examined associations between TBF and VAT, and cIMT using linear regression, adjusted for potential confounding factors, and for mediators: cardiometabolic risk factors (blood pressure, glucose and low-density lipoprotein cholesterol), and inflammation using CRP and GlycA as proxies. Mean (SD) cIMT was 615 (90) mum. Per SD of TBF (8%), cIMT was 19 mum larger (95% confidence interval, CI: 10, 28). This association was 17 mum (95% CI: 8, 27) after adjustment for cardiometabolic risk factors, and did not change after adjustment for markers of inflammation. Per SD (56 cm2) VAT, cIMT was 9 mum larger (95% CI: 2, 16) which changed to 5 mum (95% CI: -3, 12) after adjustment for cardiometabolic risk factors, and did not change after adjustment for inflammatory markers.
+
+ CONCLUSION: Our results suggest that associations between measures of overall and visceral body fat and subclinical atherosclerosis are not mediated by inflammation as measured by CRP and GlycA. Obesity may exert cardiovascular risk via other markers of systemic inflammation. Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycoproteins). 0 (Inflammation Mediators). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.numecd.2019.03.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Christen&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=The+role+of+inflammation+in+the+association+between+overall+and+visceral+adiposity+and+subclinical+atherosclerosis.&volume=29&issue=7&spage=728&epage=735&date=2019&doi=10.1016%2Fj.numecd.2019.03.010&pmid=31138500&sid=OVID:medline
+
+<1657>
+Unique Identifier
+ 31137923
+Title
+ Effect of Vitamin D3 on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study.
+Source
+ Nutrients. 11(5), 2019 May 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fernandez-Arroyo S; Hernandez-Aguilera A; de Vries MA; Burggraaf B; van der Zwan E; Pouw N; Joven J; Cabezas MC
+Authors Full Name
+ Fernandez-Arroyo, Salvador; Hernandez-Aguilera, Anna; de Vries, Marijke A; Burggraaf, Benjamin; van der Zwan, Ellen; Pouw, Nadine; Joven, Jorge; Cabezas, Manuel Castro.
+Institution
+ Fernandez-Arroyo, Salvador. Universitat Rovira i Virgili, Departament de Medicina i Cirurgia, Unitat de Recerca Biomedica, C/de l'Escorxador S/N, 43003 Tarragona, Spain. salvador.fernandez@urv.cat.
+ Fernandez-Arroyo, Salvador. Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain. salvador.fernandez@urv.cat.
+ Hernandez-Aguilera, Anna. Institut d'investigacio Sanitaria Pere Virgili, C/de l'Escorxador S/N, 43003 Tarragona, Spain. anna.hernandeza@gmail.com.
+ de Vries, Marijke A. Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. M.deVries@Franciscus.nl.
+ Burggraaf, Benjamin. Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. B.Burggraaf@Franciscus.nl.
+ van der Zwan, Ellen. Department of Clinical Chemistry, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. E.vanderZwan@Franciscus.nl.
+ Pouw, Nadine. Department of Clinical Chemistry, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. N.Pouw@Franciscus.nl.
+ Joven, Jorge. Universitat Rovira i Virgili, Departament de Medicina i Cirurgia, Unitat de Recerca Biomedica, C/de l'Escorxador S/N, 43003 Tarragona, Spain. jorge.joven@urv.cat.
+ Joven, Jorge. Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain. jorge.joven@urv.cat.
+ Joven, Jorge. Institut d'investigacio Sanitaria Pere Virgili, C/de l'Escorxador S/N, 43003 Tarragona, Spain. jorge.joven@urv.cat.
+ Cabezas, Manuel Castro. Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. M.CastroCabezas@Franciscus.nl.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Cholecalciferol/ad [Administration & Dosage]
+ Cholecalciferol/ae [Adverse Effects]
+ Dietary Supplements/ae [Adverse Effects]
+ *Dietary Supplements
+ Double-Blind Method
+ Female
+ Humans
+ *Lipidomics/mt [Methods]
+ *Lipids/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Postprandial Period
+ Treatment Outcome
+ Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/di [Diagnosis]
+ *Vitamin D Deficiency/dt [Drug Therapy]
+Keyword Heading
+ cholecalciferol
+ lipid absorption
+ lipidomics
+ obesity
+ postprandial inflammation
+ sphingomyelin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Abstract: Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and an increased risk of cardiovascular disease. Lifestyle and pharmacological treatments are usually prescribed for prevention. Vitamin D3 (cholecalciferol), as an anti-atherogenic agent, is being taken into consideration due to its potential beneficial effects in lipid metabolism and its anti-inflammatory potency. To assess the effects of vitamin D3 in the postprandial lipid profile in obese, vitamin D-deficient women, a non-targeted lipidomics approach using liquid chromatography coupled to a quadrupole time-of flight mass spectrometer was used to identify and quantitate a wide-range of circulating lipid species, including diglycerides, lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines, sphingomyelins and triglycerides. The most important changes were found in plasmatic sphingomyelin levels, which experience a decrease after vitamin D3 intake. Our results suggest a turnover of sphingomyelins, probably due to an increased activity of neutral sphingomyelinases, and, therefore, with implications in the clearance of chylomicrons, LDL and VLDL, decreasing postprandial inflammation and macrophage adherence to endothelia, potentially improving cardiovascular disease risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 1C6V77QF41 (Cholecalciferol).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11051194
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fernandez-Arroyo&issn=2072-6643&title=Nutrients&atitle=Effect+of+Vitamin+D3+on+the+Postprandial+Lipid+Profile+in+Obese+Patients%3A+A+Non-Targeted+Lipidomics+Study.&volume=11&issue=5&spage=&epage=&date=2019&doi=10.3390%2Fnu11051194&pmid=31137923&sid=OVID:medline
+
+<1658>
+Unique Identifier
+ 31135057
+Title
+ Associations of oxytocin with metabolic parameters in obese women of childbearing age.
+Source
+ Endokrynologia Polska. 70(5):417-422, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fu-Man D; Hong-Yu K; Bin-Hong D; Da-Na L; Xin-Yang Y
+Authors Full Name
+ Fu-Man, Du; Hong-Yu, Kuang; Bin-Hong, Duan; Da-Na, Liu; Xin-Yang, Yu.
+Institution
+ Fu-Man, Du. Department of Endocrinology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang Province, China, China.
+ Fu-Man, Du. Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
+ Hong-Yu, Kuang. Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. physiciankuang@outlook.com.
+ Bin-Hong, Duan. Department of Endocrinology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang Province, China, China.
+ Da-Na, Liu. Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
+ Xin-Yang, Yu. Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ Female
+ *Health Status Indicators
+ Humans
+ Insulin Resistance/ph [Physiology]
+ Male
+ *Obesity/me [Metabolism]
+ *Oxytocin/bl [Blood]
+ Triglycerides/bl [Blood]
+ Young Adult
+Keyword Heading
+ body mass index
+ childbearing
+ insulin resistance
+ lipids
+ obesity
+ oxytocin
+ quantile regression analysis
+ women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: The aim of this study was to compare plasma oxytocin levels in obese women of childbearing age with non-obese women of childbearing age, and to investigate the relationship between plasma oxytocin levels and metabolic parameters (including blood glucose, insulin resistance, blood lipid, and blood pressure).
+
+ MATERIAL AND METHODS: A total of 151 obese women of childbearing age and 160 non-obese women of childbearing age were enrolled in this study. Plasma oxytocin levels were measured by electrochemiluminescence immunoassays. Height, body weight, body mass index (BMI), fasting blood glucose (FBG), fasting insulin (FI), homeostasis model assessment for insulin resistance (HOMA-IR), total triglycerides (TG), total cholesterol (TC), low-density lipoprotein-C (LDL-C), high-density lipoprotein-C (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured in all subjects. Quantile regression analysis was used to analyse the associations of plasma oxytocin levels with FBG, FI, HOMA-IR, TG, TC, LDL-C, HDL-C, SBP, and DBP.
+
+ RESULTS: In obese women of childbearing age, plasma oxytocin levels were lower compared with non-obese controls. After adjusting for age, quantile regression analysis showed that the plasma oxytocin levels were inversely associated with HOMA-IR at the quantile level between 0.27 and 0.79 (i.e. the HOMA-IR level of 2.11 and 3.07, respectively), the plasma oxytocin levels were inversely associated with TC after the quantile level of 0.21 (i.e. the TC level of 3.78 ), and the plasma oxytocin levels were inversely associated with LDL-C at all quantile levels of LDL-C. In addition, the plasma oxytocin levels showed a positive association with HDL-C at all quantile levels of HDL-C. No significant associations were found between the plasma oxytocin levels and FBG, FI, TG, SBP, and DBP.
+
+ CONCLUSIONS: Oxytocin deficiency was common in obese women of childbearing age. Oxytocin showed negative correlation with HOMA-IR, TC, and LDL-C, while it showed positive association with HDL-C. Our findings suggest that oxytocin played an important role in inhibiting metabolic disorders associated with obesity in women of childbearing age.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Triglycerides). 50-56-6 (Oxytocin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.5603%2fEP.a2019.0028
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fu-Man&issn=0423-104X&title=Endokrynologia+Polska&atitle=Associations+of+oxytocin+with+metabolic+parameters+in+obese+women+of+childbearing+age.&volume=70&issue=5&spage=417&epage=422&date=2019&doi=10.5603%2FEP.a2019.0028&pmid=31135057&sid=OVID:medline
+
+<1659>
+Unique Identifier
+ 31132775
+Title
+ Indirect Effects of Body Mass Index Growth on Glucose Dysregulation via Inflammation: Causal Moderated Mediation Analysis.
+Source
+ Obesity Facts. 12(3):316-327, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fong TCT
+Authors Full Name
+ Fong, Ted Chun Tat.
+Institution
+ Fong, Ted Chun Tat. Center for Behavioral Health, The University of Hong Kong, Hong Kong, Hong Kong, ttaatt@hku.hk.
+MeSH Subject Headings
+ Adiposity/ph [Physiology]
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ *Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ C-Reactive Protein/me [Metabolism]
+ Causality
+ Child
+ Female
+ *Glucose/me [Metabolism]
+ *Glucose Metabolism Disorders/et [Etiology]
+ Glucose Metabolism Disorders/im [Immunology]
+ Glucose Metabolism Disorders/me [Metabolism]
+ Glycated Hemoglobin/me [Metabolism]
+ Homeostasis
+ Humans
+ *Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ Longitudinal Studies
+ Male
+ Models, Theoretical
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/im [Immunology]
+ Obesity/me [Metabolism]
+ Young Adult
+Keyword Heading
+ C-reactive protein
+ Childhood obesity
+ Inflammation
+ Moderated mediation
+ Prediabetes
+ Weight gain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: No existing studies have examined the mediating role of chronic inflammation between obesity and dysregulated glucose homeostasis in adolescent samples. This study evaluated whether C-reactive protein (CRP), an inflammation biomarker, mediated the effects of growth (annual increase) in body mass index (BMI) on glycated hemoglobin (HbA1c).
+
+ METHODS: BMI and biomarker data were used from wave I to wave IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health study; 4,545 adolescents; mean age = 14.9 years; 55.7% female) with valid CRP data. A causal moderated mediation analysis evaluated the direct and indirect effects of BMI slope on HbA1c via CRP across gender, with demographic and clinical characteristics as model covariates.
+
+ RESULTS: The participants displayed a linear BMI growth of 0.53-0.58 kg/m2/year throughout adolescence, with substantial interindividual variation. The BMI slope showed positive direct and indirect effects on HbA1c via CRP across gender, and there was a significant exposure-mediator interaction effect. A standardized increase in the BMI slope raised the probability of an abnormal HbA1c value by 6.0-8.5% in participants with various profiles. The total natural indirect effect accounted for 13.3-15.9% of the total effect in males and 21.2-22.7% in females.
+
+ CONCLUSIONS: The findings provide support for the inflammation mechanism in the effects of adiposity on glucose homeostasis. In adolescents, excess BMI growth was linked with a higher risk of glucose dysregulation either directly or indirectly via chronic inflammation. Copyright © 2019 The Author(s) Published by S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 9007-41-4 (C-Reactive Protein). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1159%2f000500422
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fong&issn=1662-4025&title=Obesity+Facts&atitle=Indirect+Effects+of+Body+Mass+Index+Growth+on+Glucose+Dysregulation+via+Inflammation%3A+Causal+Moderated+Mediation+Analysis.&volume=12&issue=3&spage=316&epage=327&date=2019&doi=10.1159%2F000500422&pmid=31132775&sid=OVID:medline
+
+<1660>
+Unique Identifier
+ 31128615
+Title
+ Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study.
+Source
+ Respiratory Medicine. 152:81-88, 2019 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Husebo GR; Nielsen R; Hardie J; Bakke PS; Lerner L; D'Alessandro-Gabazza C; Gyuris J; Gabazza E; Aukrust P; Eagan T
+Authors Full Name
+ Husebo, Gunnar R; Nielsen, Rune; Hardie, Jon; Bakke, Per Sigvald; Lerner, Lorena; D'Alessandro-Gabazza, Corina; Gyuris, Jeno; Gabazza, Esteban; Aukrust, Pal; Eagan, Tomas.
+Institution
+ Husebo, Gunnar R. Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway; Dept. of Clinical Science, University of Bergen, Norway. Electronic address: Gunnar.Husebo@uib.no.
+ Nielsen, Rune. Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.
+ Hardie, Jon. Dept. of Clinical Science, University of Bergen, Norway.
+ Bakke, Per Sigvald. Dept. of Clinical Science, University of Bergen, Norway.
+ Lerner, Lorena. AVEO Oncology, Cambridge, MA, USA.
+ D'Alessandro-Gabazza, Corina. Dept. of Immunology, Mie University, Tsu City, Japan.
+ Gyuris, Jeno. AVEO Oncology, Cambridge, MA, USA.
+ Gabazza, Esteban. Dept. of Immunology, Mie University, Tsu City, Japan.
+ Aukrust, Pal. Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
+ Eagan, Tomas. Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway; Dept. of Clinical Science, University of Bergen, Norway.
+MeSH Subject Headings
+ Administration, Inhalation
+ Aged
+ Biomarkers/bl [Blood]
+ Bronchitis, Chronic/co [Complications]
+ Bronchitis, Chronic/ep [Epidemiology]
+ Cohort Studies
+ Comorbidity
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ Inflammation/me [Metabolism]
+ *Lung Neoplasms/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Predictive Value of Tests
+ Prospective Studies
+ Pulmonary Disease, Chronic Obstructive/bl [Blood]
+ *Pulmonary Disease, Chronic Obstructive/co [Complications]
+ *Pulmonary Disease, Chronic Obstructive/ep [Epidemiology]
+ Pulmonary Disease, Chronic Obstructive/pp [Physiopathology]
+ Pulmonary Emphysema/dg [Diagnostic Imaging]
+ *Pulmonary Emphysema/ep [Epidemiology]
+ Risk Factors
+ Smoking/ae [Adverse Effects]
+ Smoking/ep [Epidemiology]
+ Spirometry/mt [Methods]
+ Steroids/ad [Administration & Dosage]
+ Steroids/ae [Adverse Effects]
+ Steroids/tu [Therapeutic Use]
+ Symptom Flare Up
+Keyword Heading
+ COPD
+ Inflammation
+ Lung cancer
+ Phenotypes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: COPD patients have an increased risk of developing lung cancer, but the underlying mechanisms are poorly understood. We aimed to identify risk factors for lung cancer in patients from the Bergen COPD Cohort Study.
+
+ METHODS: We compared 433 COPD patients with 279 healthy controls, all former or current smokers. All COPD patients had FEV1<80% and FEV1/FVC-ratio<0.7. Baseline predictors were sex, age, spirometry, body composition, smoking history, emphysema assessed by CT, chronic bronchitis, prior exacerbation frequency, Charlson Comorbidity Score, inhalation medication and 44 serum/plasma inflammatory biomarkers. Patients were followed up for 9 years recording incidence of lung cancer. Cox-regression models were fitted for the statistical analyses. The biomarkers were evaluated using principal component analysis.
+
+ RESULTS: 28 COPD patients and 3 controls developed lung cancer, COPD patients had a significantly higher risk of developing lung cancer, (HR 5.0; 95% CI 1.5-17.1, p<0.01, adjusted values). Among COPD patients, emphysema (HR 4.4; 1.7-10.8, p<0.01) and obesity (HR 3.3; 1.3-8.5, p=0.02) were associated with a higher cancer rate. Use of inhaled steroids was associated with a lower rate (HR 0.4; 0.2-0.9, p=0.03). Smoking status, pack-years smoked or levels of systemic inflammatory markers, except for interferon gamma-induced protein 10, did not affect the lung cancer rate in patients with COPD.
+
+ CONCLUSION: Patients with COPD have a higher lung cancer rate compared to healthy controls adjusted for smoking. The presence of emphysema and obesity in COPD predicted a higher lung cancer risk in COPD patients. Systemic inflammation was not associated with increased lung cancer risk. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Steroids).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.rmed.2019.04.019
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Husebo&issn=0954-6111&title=Respiratory+Medicine&atitle=Risk+factors+for+lung+cancer+in+COPD+-+results+from+the+Bergen+COPD+cohort+study.&volume=152&issue=&spage=81&epage=88&date=2019&doi=10.1016%2Fj.rmed.2019.04.019&pmid=31128615&sid=OVID:medline
+
+<1661>
+Unique Identifier
+ 31112015
+Title
+ Adipose Tissue Protein Glycoxidation is Associated with Weight-Loss Potential.
+Source
+ Obesity. 27(7):1133-1140, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Serrano JCE; Baena-Fustegueras JA; Martin-Gari M; Rassendren H; Cassanye A; Naudi A; Lopez-Cano C; Sanchez E; de la Fuente-Juarez MC; Herrerias Gonzalez F; Olsina Kissler JJ; Lecube A; Portero-Otin M
+Author NameID
+ Serrano, Jose C E; ORCID: https://orcid.org/0000-0001-6714-6061
+Authors Full Name
+ Serrano, Jose C E; Baena-Fustegueras, Juan Antonio; Martin-Gari, Meritxell; Rassendren, Helene; Cassanye, Anna; Naudi, Alba; Lopez-Cano, Carolina; Sanchez, Enric; de la Fuente-Juarez, Maria Cruz; Herrerias Gonzalez, Fernando; Olsina Kissler, Jorge J; Lecube, Albert; Portero-Otin, Manuel.
+Institution
+ Serrano, Jose C E. Department of Experimental Medicine, University of Lleida, Lleida, Spain.
+ Baena-Fustegueras, Juan Antonio. General and Digestive Surgery Service, Endocrine, Bariatric and Metabolic Surgery Unit, Arnau de Vilanova University Hospital, Lleida, Spain.
+ Martin-Gari, Meritxell. Department of Experimental Medicine, University of Lleida, Lleida, Spain.
+ Rassendren, Helene. Department of Experimental Medicine, University of Lleida, Lleida, Spain.
+ Cassanye, Anna. Department of Experimental Medicine, University of Lleida, Lleida, Spain.
+ Naudi, Alba. Department of Experimental Medicine, University of Lleida, Lleida, Spain.
+ Lopez-Cano, Carolina. Endocrinology and Nutrition Department, Arnau de Vilanova University Hospital; and Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomedica de Lleida (IRBLleida), University of Lleida, Lleida, Spain.
+ Sanchez, Enric. Endocrinology and Nutrition Department, Arnau de Vilanova University Hospital; and Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomedica de Lleida (IRBLleida), University of Lleida, Lleida, Spain.
+ de la Fuente-Juarez, Maria Cruz. General and Digestive Surgery Service, Endocrine, Bariatric and Metabolic Surgery Unit, Arnau de Vilanova University Hospital, Lleida, Spain.
+ Herrerias Gonzalez, Fernando. General and Digestive Surgery Service, Endocrine, Bariatric and Metabolic Surgery Unit, Arnau de Vilanova University Hospital, Lleida, Spain.
+ Olsina Kissler, Jorge J. General and Digestive Surgery Service, Endocrine, Bariatric and Metabolic Surgery Unit, Arnau de Vilanova University Hospital, Lleida, Spain.
+ Lecube, Albert. Endocrinology and Nutrition Department, Arnau de Vilanova University Hospital; and Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomedica de Lleida (IRBLleida), University of Lleida, Lleida, Spain.
+ Lecube, Albert. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
+ Portero-Otin, Manuel. Department of Experimental Medicine, University of Lleida, Lleida, Spain.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Adult
+ Aged
+ Animals
+ *Bariatric Surgery/mt [Methods]
+ *Biomarkers/me [Metabolism]
+ Disease Models, Animal
+ Female
+ Glycosylation
+ Humans
+ Male
+ Mice
+ Middle Aged
+ *Obesity/th [Therapy]
+ Oxidation-Reduction
+ *Proteins/me [Metabolism]
+ *Weight Loss/ph [Physiology]
+ Young Adult
+Abstract
+ OBJECTIVE: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight-loss success.
+
+ METHODS: A human model, in which sixty-five individuals with obesity underwent bariatric surgery, and a diet-induced obesity animal model, in which animals were treated for 2 months with normocaloric diets, were analyzed to determine the associations between AT protein oxidation and body weight loss. Protein oxidative biomarkers were determined by gas chromatography/mass spectrometry in AT from human volunteers before the surgery, as well as 2 months after a diet treatment in the animal model.
+
+ RESULTS: The levels of carboxyethyl-lysine (CEL) and 2-succinocystein (2SC) in both visceral and subcutaneous AT before the surgery directly correlated with greater weight loss in both human and animal models. 2SC levels in subcutaneous AT greater than 4.7 x 106 mumol/mol lysine (95% CI: 3.4 x 106 to 6.0 x 106 ) may predict greater weight loss after bariatric surgery (receiver operating characteristic curve area = 0.8222; P = 0.0047). Additionally, it was observed that individuals with diabetes presented lower levels of CEL and 2SC in subcutaneous AT (P = 0.0266 and P = 0.0316, respectively) compared with individuals without diabetes.
+
+ CONCLUSIONS: CEL and 2SC in AT are useful biomarkers of AT metabolism and predict the individual's ability to reduce body weight after bariatric surgery. Copyright © 2019 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteins).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2foby.22501
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Serrano&issn=1930-7381&title=Obesity&atitle=Adipose+Tissue+Protein+Glycoxidation+is+Associated+with+Weight-Loss+Potential.&volume=27&issue=7&spage=1133&epage=1140&date=2019&doi=10.1002%2Foby.22501&pmid=31112015&sid=OVID:medline
+
+<1662>
+Unique Identifier
+ 31109784
+Title
+ High-intensity interval exercise lowers postprandial glucose concentrations more in obese adults than lean adults.
+Source
+ Primary care diabetes. 13(6):568-573, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kong Z; Shi Q; Sun S; Tong TK; Zhang H; Nie J
+Authors Full Name
+ Kong, Zhaowei; Shi, Qingde; Sun, Shengyan; Tong, Tomas K; Zhang, Haifeng; Nie, Jinlei.
+Institution
+ Kong, Zhaowei. Faculty of Education, University of Macau, Macao, China. Electronic address: zwkong@umac.mo.
+ Shi, Qingde. School of Physical Education and Sports, Macao Polytechnic Institute, Macao, China. Electronic address: qdshi@ipm.edu.mo.
+ Sun, Shengyan. Faculty of Education, University of Macau, Macao, China; Institute of Physical Education, Huzhou University, Huzhou, Zhejiang Province, China. Electronic address: sysun@zjhu.edu.cn.
+ Tong, Tomas K. Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Department of Physical Education, Hong Kong Baptist University, Hong Kong, China. Electronic address: tongkk@hkbu.edu.hk.
+ Zhang, Haifeng. College of Physical Education, Hebei Normal University, Shijiazhuang, Hebei Province, China. Electronic address: hbnuzhanghaifeng@sina.com.
+ Nie, Jinlei. School of Physical Education and Sports, Macao Polytechnic Institute, Macao, China. Electronic address: jnie@ipm.edu.mo.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ Humans
+ *Life Style
+ Male
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ *Physical Exertion/ph [Physiology]
+ *Postprandial Period/ph [Physiology]
+ Thinness/bl [Blood]
+ *Thinness/pp [Physiopathology]
+ Young Adult
+Keyword Heading
+ Fat-free mass
+ Glycaemic control
+ Obesity
+ Sprint exercise
+ Wingate test
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: To compare postprandial glucose responses to high-intensity interval exercise (HIE) between obese and lean individuals.
+
+ METHODS: Thirty healthy young adult males (15 obese, 15 lean) ate a standardised meal, then performed HIE (4 x 30-s Wingate cycling/4-min rest) or a no-exercise control trial (CON). Blood glucose was measured preprandially and up to 150 min postprandially.
+
+ RESULTS: Compared to CON, HIE reduced postprandial glucose concentrations at 120-150 min in obese (p < 0.001) and lean men (p < 0.05), with greater reductions in obese than lean subjects at 120 (-27.0% vs. -8.3%), 135 (-31.9% vs. -15.7%), and 150 min (-21.8% vs. -10.6%). The total glucose area under the curve (AUC) for the testing period was lower with HIE than CON among obese men (p < 0.05), but not lean men (p > 0.05). We found moderate correlations between body mass and postprandial glucose changes (r = 0.39-0.44, p < 0.05), and between glucose AUC and body mass and fat free mass (r = 0.39-0.48, p < 0.05).
+
+ CONCLUSIONS: Our findings suggest that HIE may act as a time-efficient lifestyle intervention strategy for improving obesity-related diabetes risk factors, and might play a role in primary diabetes prevention for the healthy but sedentary population. Copyright © 2019 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Controlled Clinical Trial. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.pcd.2019.04.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kong&issn=1878-0210&title=Primary+care+diabetes&atitle=High-intensity+interval+exercise+lowers+postprandial+glucose+concentrations+more+in+obese+adults+than+lean+adults.&volume=13&issue=6&spage=568&epage=573&date=2019&doi=10.1016%2Fj.pcd.2019.04.003&pmid=31109784&sid=OVID:medline
+
+<1663>
+Unique Identifier
+ 31104052
+Title
+ SCCA-IgM as a Potential Biomarker of Non-Alcoholic Fatty Liver Disease in Patients with Obesity, Prediabetes and Diabetes Undergoing Sleeve Gastrectomy.
+Source
+ Obesity Facts. 12(3):291-306, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bettini S; Bordigato E; Milan G; Dal Pra' C; Favaretto F; Belligoli A; Sanna M; Serra R; Foletto M; Prevedello L; Busetto L; Fassina G; Vettor R; Fabris R
+Authors Full Name
+ Bettini, Silvia; Bordigato, Emanuel; Milan, Gabriella; Dal Pra', Chiara; Favaretto, Francesca; Belligoli, Anna; Sanna, Marta; Serra, Roberto; Foletto, Mirto; Prevedello, Luca; Busetto, Luca; Fassina, Giorgio; Vettor, Roberto; Fabris, Roberto.
+Institution
+ Bettini, Silvia. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy, d.ssa.silvia.bettini@gmail.com.
+ Bettini, Silvia. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy, d.ssa.silvia.bettini@gmail.com.
+ Bordigato, Emanuel. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Bordigato, Emanuel. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Milan, Gabriella. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Milan, Gabriella. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Dal Pra', Chiara. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Dal Pra', Chiara. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Favaretto, Francesca. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Favaretto, Francesca. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Belligoli, Anna. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Belligoli, Anna. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Sanna, Marta. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Sanna, Marta. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Serra, Roberto. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Serra, Roberto. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Foletto, Mirto. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Foletto, Mirto. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Prevedello, Luca. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Prevedello, Luca. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Busetto, Luca. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Busetto, Luca. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Fassina, Giorgio. Xeptagen S.p.A., Venice, Italy.
+ Vettor, Roberto. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Vettor, Roberto. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+ Fabris, Roberto. Center for the Study and Integrated Treatment of Obesity, University Hospital of Padua, Padua, Italy.
+ Fabris, Roberto. Internal Medicine 3, Department of Medicine, University Hospital of Padua, Padua, Italy.
+MeSH Subject Headings
+ Adult
+ Antigens, Neoplasm/bl [Blood]
+ *Antigens, Neoplasm/im [Immunology]
+ *Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/su [Surgery]
+ Female
+ Follow-Up Studies
+ Gastrectomy/mt [Methods]
+ Gastrectomy/rh [Rehabilitation]
+ Humans
+ *Immunoglobulin M/bl [Blood]
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/su [Surgery]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/su [Surgery]
+ Obesity, Morbid/bl [Blood]
+ Obesity, Morbid/co [Complications]
+ Obesity, Morbid/di [Diagnosis]
+ Obesity, Morbid/su [Surgery]
+ *Prediabetic State/bl [Blood]
+ Prediabetic State/co [Complications]
+ Prediabetic State/di [Diagnosis]
+ Prediabetic State/su [Surgery]
+ Prognosis
+ Risk Factors
+ Serpins/bl [Blood]
+ *Serpins/im [Immunology]
+ Treatment Outcome
+ Weight Loss
+Keyword Heading
+ Bariatric surgery
+ Diabetes
+ Non-alcoholic fatty liver disease
+ Obesity
+ Prediabetes
+ SCCA-IgM
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has a high prevalence in obesity and its presence should be screened. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for obesity, but its effects on NAFLD are still to be firmly established. The diagnosis of non-alcoholic steatohepatitis (NASH) is currently performed by liver biopsy, a costly and invasive procedure. Squamous cell carcinoma antigen-IgM (SCCA-IgM) is a biomarker of viral hepatitis to hepatocellular carcinoma development and its role in NAFLD to NASH progression has not yet been investigated.
+
+ OBJECTIVE: The aim of this study was to evaluate SCCA-IgM as a non-invasive biomarker of NAFLD/NASH in patients with different degrees of metabolic-complicated obesity before and after LSG.
+
+ METHOD: Fifty-six patients with obesity were studied before and 12 months after LSG; anthropometric, biochemical, clinical, and imaging data were collected.
+
+ RESULTS: At baseline steatosis was strongly associated with the glycaemic profile (p = 0.016) and was already present in prediabetic patients with obesity (82%). Only 3 patients had an SCCA-IgM level above the normal cut-off. SCCA-IgM titre did not change according to glycaemic profile or steatosis. Metabolic and inflammatory factors and transaminases significantly reduced after LSG-induced weight loss, except for SCCA-IgM. The ALT/AST ratio decreased post-LSG correlated with BMI (r = 0.297, p = 0.031), insulin (r = 0.354, p = 0.014), and triglycerides (r = 0.355, p = 0.009) reduction.
+
+ CONCLUSIONS: Our results confirm the tight link between NAFLD and metabolic complications, suggesting prediabetes as a new risk factor of steatosis. SCCA-IgM does not seem to have a role in the identification and prognosis of NAFLD. Copyright © 2019 The Author(s) Published by S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Antigens, Neoplasm). 0 (Biomarkers). 0 (Immunoglobulin M). 0 (Serpins). 0 (squamous cell carcinoma-related antigen).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1159%2f000499717
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bettini&issn=1662-4025&title=Obesity+Facts&atitle=SCCA-IgM+as+a+Potential+Biomarker+of+Non-Alcoholic+Fatty+Liver+Disease+in+Patients+with+Obesity%2C+Prediabetes+and+Diabetes+Undergoing+Sleeve+Gastrectomy.&volume=12&issue=3&spage=291&epage=306&date=2019&doi=10.1159%2F000499717&pmid=31104052&sid=OVID:medline
+
+<1664>
+Unique Identifier
+ 31102776
+Title
+ The ratio adipsin/MCP-1 is strongly associated with structural changes and CRP/MCP-1 with symptoms in obese knee osteoarthritis subjects: data from the Osteoarthritis Initiative.
+Source
+ Osteoarthritis & Cartilage. 27(8):1163-1173, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Martel-Pelletier J; Tardif G; Rousseau Trepanier J; Abram F; Dorais M; Raynauld JP; Pelletier JP
+Authors Full Name
+ Martel-Pelletier, J; Tardif, G; Rousseau Trepanier, J; Abram, F; Dorais, M; Raynauld, J-P; Pelletier, J-P.
+Institution
+ Martel-Pelletier, J. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. Electronic address: jm@martelpelletier.ca.
+ Tardif, G. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. Electronic address: tardifgi@yahoo.com.
+ Rousseau Trepanier, J. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. Electronic address: jtrepanier@arthrolab.com.
+ Abram, F. Medical Imaging Research & Development, ArthroLab Inc., Montreal, Quebec, Canada. Electronic address: fabram@arthrovision.biz.
+ Dorais, M. StatSciences Inc., Notre-Dame-de-l'Ile-Perrot, Quebec, Canada. Electronic address: marc.dorais.statsciences@gmail.com.
+ Raynauld, J-P. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. Electronic address: jp.raynauld@videotron.ca.
+ Pelletier, J-P. Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. Electronic address: dr@jppelletier.ca.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *C-Reactive Protein/an [Analysis]
+ *Cartilage, Articular/dg [Diagnostic Imaging]
+ *Chemokine CCL2/bl [Blood]
+ *Complement Factor D/an [Analysis]
+ *Disease Progression
+ Female
+ Humans
+ Magnetic Resonance Imaging
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ *Osteoarthritis, Knee/dg [Diagnostic Imaging]
+ Osteoarthritis, Knee/ep [Epidemiology]
+ Pain Measurement
+Keyword Heading
+ Adipokines
+ Biomarkers
+ Inflammatory factors
+ Magnetic resonance imaging
+ Osteoarthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: There is a need to identify reliable biomarkers that can predict knee osteoarthritis (OA) progression. We investigated a panel of adipokines and some related inflammatory factors alone and their ratios for their associative value at assessing cartilage volume loss over time and symptoms in obese [High body mass index (BMI)] and non-obese (Low BMI) OA subjects.
+
+ DESIGN: Human OA serum was from the Osteoarthritis Initiative Progression subcohort. Baseline levels of adiponectin (high and low molecular weight forms), adipsin, chemerin, leptin, visfatin, C-reactive protein (CRP), interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) were evaluated with specific assays. Cartilage volume was assessed at baseline and 48 months by quantitative magnetic resonance imaging (MRI), and symptoms using baseline Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. Data were analysed by linear regression with confounding factors at baseline, followed by multiple comparison adjustment.
+
+ RESULTS: The levels of the nine biomarkers and their ratios (36) were studied. Among High BMI subjects, only the ratio adipsin/MCP-1 was associated with cartilage volume loss over time in the lateral compartment [beta, -2.95; 95% confidence interval (CI), -4.42, -1.49; P = 0.010], whereas MCP-1 was associated with WOMAC pain (-1.74; -2.75, -0.73; P = 0.030) and the ratio CRP/MCP-1 with WOMAC pain (0.76; 0.37, 1.14; P = 0.023), function (2.43; 1.20, 3.67; P = 0.020) and total (3.29; 1.58, 5.00; P = 0.027). No associations were found for biomarkers or ratios in Low BMI OA.
+
+ CONCLUSION: In this study, the ratio adipsin/MCP-1 was found to be associated with the knee structural changes and that of CRP/MCP-1 with symptoms in obese OA subjects. Our data further underline the relevance of ratios as biomarkers to a stronger association to OA progression and symptoms. Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Chemokine CCL2). 9007-41-4 (C-Reactive Protein). EC 3-4-21-46 (Complement Factor D).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.joca.2019.04.016
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Martel-Pelletier&issn=1063-4584&title=Osteoarthritis+%26+Cartilage&atitle=The+ratio+adipsin%2FMCP-1+is+strongly+associated+with+structural+changes+and+CRP%2FMCP-1+with+symptoms+in+obese+knee+osteoarthritis+subjects%3A+data+from+the+Osteoarthritis+Initiative.&volume=27&issue=8&spage=1163&epage=1173&date=2019&doi=10.1016%2Fj.joca.2019.04.016&pmid=31102776&sid=OVID:medline
+
+<1665>
+Unique Identifier
+ 31093862
+Title
+ Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis.
+Source
+ Obesity Surgery. 29(8):2631-2647, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Askarpour M; Khani D; Sheikhi A; Ghaedi E; Alizadeh S
+Authors Full Name
+ Askarpour, Moein; Khani, Dana; Sheikhi, Ali; Ghaedi, Ehsan; Alizadeh, Shahab.
+Institution
+ Askarpour, Moein. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Khani, Dana. Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
+ Sheikhi, Ali. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Ghaedi, Ehsan. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
+ Ghaedi, Ehsan. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Alizadeh, Shahab. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Poorsina Street, Enghelab Avenue, PO Box: 14155-6446, Tehran, Iran. Alizadeh.mnutr@gmail.com.
+MeSH Subject Headings
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/co [Complications]
+ *Inflammation Mediators/bl [Blood]
+ Interleukin-6/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ *Obesity/su [Surgery]
+ Postoperative Period
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ Bariatric surgery
+ C-reactive protein
+ Interleukin 6
+ Meta-analysis
+ Tumor necrosis factor-alpha
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is one of the main causes of inflammation. Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers. This systematic review and meta-analysis is aimed at describing the effect of bariatric surgery on C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha). PubMed/Medline and Scopus were systematically searched for all eligible studies from inception to June 2018. Results are expressed as weighted mean difference (MD) with 95% confidence intervals (CI) using a random effects model. Overall, 116 studies which evaluated serum CRP, IL-6, and TNF-alpha after bariatric surgery were included. Pooled effect size showed significant reduction in serum CRP (- 5.30 mg/l, 95% CI - 5.46, - 5.15, P < 0.001), IL-6 (- 0.58 pg/ml, 95% CI - 0.64, - 0.53, P < 0.001), and TNF-alpha (- 0.20 pg/ml, 95% CI - 0.39, - 0.02, P = 0.031) with significant heterogeneity across studies (> 95% for all factors). Bariatric surgery significantly lowered inflammatory factors; however, baseline BMI, follow-up duration and type of surgery could impact the extent of observed effects.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11695-019-03926-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Askarpour&issn=0960-8923&title=Obesity+Surgery&atitle=Effect+of+Bariatric+Surgery+on+Serum+Inflammatory+Factors+of+Obese+Patients%3A+a+Systematic+Review+and+Meta-Analysis.&volume=29&issue=8&spage=2631&epage=2647&date=2019&doi=10.1007%2Fs11695-019-03926-0&pmid=31093862&sid=OVID:medline
+
+<1666>
+Unique Identifier
+ 31093012
+Title
+ Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women.
+Source
+ Mediators of Inflammation. 2019:4165260, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gomez-Huelgas R; Ruiz-Nava J; Santamaria-Fernandez S; Vargas-Candela A; Alarcon-Martin AV; Tinahones FJ; Bernal-Lopez MR
+Author NameID
+ Gomez-Huelgas, Ricardo; ORCID: https://orcid.org/0000-0002-9909-3555
+ Tinahones, Francisco J; ORCID: https://orcid.org/0000-0001-6871-4403
+ Bernal-Lopez, M Rosa; ORCID: https://orcid.org/0000-0002-0238-0890
+Authors Full Name
+ Gomez-Huelgas, Ricardo; Ruiz-Nava, Josefina; Santamaria-Fernandez, Sonia; Vargas-Candela, Antonio; Alarcon-Martin, Ana Victoria; Tinahones, Francisco J; Bernal-Lopez, M Rosa.
+Institution
+ Gomez-Huelgas, Ricardo. Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga-IBIMA, Regional University Hospital of Malaga, Spain.
+ Gomez-Huelgas, Ricardo. CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain.
+ Gomez-Huelgas, Ricardo. University of Malaga, Spain.
+ Ruiz-Nava, Josefina. Endocrinology and Nutrition Department, Instituto de Investigacion Biomedica de Malaga-IBIMA, University Hospital of Malaga (Virgen de la Victoria Hospital), Spain.
+ Santamaria-Fernandez, Sonia. Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga-IBIMA, Regional University Hospital of Malaga, Spain.
+ Vargas-Candela, Antonio. Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga-IBIMA, Regional University Hospital of Malaga, Spain.
+ Alarcon-Martin, Ana Victoria. Endocrinology and Nutrition Department, Instituto de Investigacion Biomedica de Malaga-IBIMA, University Hospital of Malaga (Virgen de la Victoria Hospital), Spain.
+ Tinahones, Francisco J. CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain.
+ Tinahones, Francisco J. University of Malaga, Spain.
+ Tinahones, Francisco J. Endocrinology and Nutrition Department, Instituto de Investigacion Biomedica de Malaga-IBIMA, University Hospital of Malaga (Virgen de la Victoria Hospital), Spain.
+ Bernal-Lopez, M Rosa. Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga-IBIMA, Regional University Hospital of Malaga, Spain.
+ Bernal-Lopez, M Rosa. CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Weight/ph [Physiology]
+ Diet, Mediterranean
+ Exercise/ph [Physiology]
+ Female
+ Humans
+ Middle Aged
+ *Obesity/bl [Blood]
+ Weight Loss/ph [Physiology]
+Abstract
+ BACKGROUND: For the metabolically healthy obese (MHO) subjects, it is unclear whether weight loss provides cardiometabolic benefits. Our objective was to evaluate whether changes in adipokine and inflammatory biomarker levels were related to lifestyle modification (with Mediterranean diet and physical exercise program).
+
+ METHODS: 115 women (35-55 years) with BMI of 30-40 kg/m2 and <=1 metabolic syndrome criteria were included. After a 2-year intervention, participants were classified by percent weight loss: Group 1, <5%; Group 2, >=5%-<10%; and Group 3, >=10%. Anthropometric data, inflammatory biomarker (IL-6, TNFa, and hsCRP) and adipokine levels (adiponectin and resistin), and lifestyle program adherence at baseline and 2 years were analyzed.
+
+ RESULTS: The final sample comprised 67 women. 23 (38.3%) lost <5%, 22 (36.7%) lost >=5%-<10%, and 22 (36.7%) lost >=10% of baseline weight. After 2 years, in Group 1, adiponectin, hsCRP, IL-6, and TNFa decreased (-1.2 ng/ml, p = 0.003; -2.1 mg/l, p = 0.003; -2.4 pg/ml, p < 0.001; and -2.4 pg/ml, p = 0.001, respectively) and resistin increased (+2.4 ng/ml, p < 0.001). In Group 2, hsCRP and IL-6 decreased (-2.0 mg/l, p = 0.009 and -2.6 pg/ml, p = 0.001) but TNFa increased (+0.2 pg/ml, p = 0.02). In Group 3, resistin increased (+3.5 ng/ml, p < 0.001) but hsCRP, IL-6, and TNFa decreased (-2.0 mg/l, p = 0.009; -2.5 pg/ml, p < 0.001; and -4.1 pg/ml, p < 0.001). Adiponectin, hsCRP, and physical exercise correlated significantly to subjects' dietary adherence.
+
+ CONCLUSION: Weight loss reduces inflammatory biomarkers in the MHO but induces a deterioration in the adipokine profile, which does not improve with diet and exercise intervention. These findings allow us to clarify mechanisms behind inflammation and metabolic disorder genesis so as to prevent development of obesity-associated comorbidities.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f4165260
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gomez-Huelgas&issn=0962-9351&title=Mediators+of+Inflammation&atitle=Impact+of+Intensive+Lifestyle+Modification+on+Levels+of+Adipokines+and+Inflammatory+Biomarkers+in+Metabolically+Healthy+Obese+Women.&volume=2019&issue=&spage=4165260&epage=&date=2019&doi=10.1155%2F2019%2F4165260&pmid=31093012&sid=OVID:medline
+
+<1667>
+Unique Identifier
+ 31089732
+Title
+ Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
+Source
+ Advances in Nutrition. 10(suppl_2):S239-S250, 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ulven SM; Holven KB; Gil A; Rangel-Huerta OD
+Authors Full Name
+ Ulven, Stine M; Holven, Kirsten B; Gil, Angel; Rangel-Huerta, Oscar D.
+Institution
+ Ulven, Stine M. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
+ Holven, Kirsten B. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
+ Holven, Kirsten B. Norwegian National Advisory Unit on Familial Hypercholesterolemia, Oslo University Hospital, Oslo, Norway.
+ Gil, Angel. Department of Biochemistry and Molecular Biology II, School of Pharmacy.
+ Gil, Angel. Institute of Nutrition and Food Technology "Jose Mataix," Biomedical Research Center, University of Granada, Granada, Spain.
+ Gil, Angel. ibs.GRANADA, University Hospital Complex of Granada, Granada, Spain.
+ Gil, Angel. CIBEROBN (CIBER Physiopathology of Obesity and Nutrition CB12/03/30028), Institute of Health Carlos III, Madrid, Spain.
+ Rangel-Huerta, Oscar D. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
+MeSH Subject Headings
+ Animals
+ *Anti-Inflammatory Agents/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ *Dairy Products
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diet
+ *Feeding Behavior
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/et [Etiology]
+ *Inflammation/pc [Prevention & Control]
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/co [Complications]
+ Milk
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+Keyword Heading
+ dairy products
+ diabetes
+ healthy
+ inflammation
+ inflammatory biomarkers
+ metabolic syndrome
+ milk
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Milk and dairy products contribute <=14% of the caloric intake in developed countries. Recent evidence has shown controversial results with regard to the role of dairy products in deleterious processes such as inflammation. The increasing number of studies on the anti- and proinflammatory effects of milk and dairy products in the past 5 y reflects the growing interest in this area of research. The aim of this systematic review was to evaluate the scientific evidence provided in the past 5 y on the effects of milk and dairy products on inflammatory biomarkers provided by randomized clinical trials. The search strategy was conducted in Medline (via PubMed) and Scopus (which includes EMBASE and the Web of Science) databases and included articles from 1 January 2012 to 30 April 2018. The risk of bias was assessed using the Cochrane methodology. The number of study participants, type of study, doses, and the key results are reported. The following primary outcomes were considered for inclusion: circulating concentrations of C-reactive protein, interleukins, cytokines, and vascular adhesion molecules or expression of proinflammatory genes in peripheral blood mononuclear cells; however, the primary outcomes considered were not limited to these. Sixteen studies (15 articles) included in this systematic review reported on healthy individuals and subjects who were overweight or obese and who had metabolic syndrome or type 2 diabetes. The consumption of milk or dairy products did not show a proinflammatory effect in healthy subjects or individuals with metabolic abnormalities. The majority of studies documented a significant anti-inflammatory effect in both healthy and metabolically abnormal subjects, although not all the articles were of high quality. This review was registered on PROSPERO (International Prospective Register of Systematic Reviews) at https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=94535 as CRD42018094535. Copyright © American Society for Nutrition 2019.
+Registry Number/Name of Substance
+ 0 (Anti-Inflammatory Agents). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fadvances%2fnmy072
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ulven&issn=2161-8313&title=Advances+in+Nutrition&atitle=Milk+and+Dairy+Product+Consumption+and+Inflammatory+Biomarkers%3A+An+Updated+Systematic+Review+of+Randomized+Clinical+Trials.&volume=10&issue=2&spage=S239&epage=S250&date=2019&doi=10.1093%2Fadvances%2Fnmy072&pmid=31089732&sid=OVID:medline
+
+<1668>
+Unique Identifier
+ 31088654
+Title
+ Beneficial effect of sugar-sweetened beverages on the risk of urinary tract infections.
+Source
+ Medical Hypotheses. 127:84-87, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Conka J; Meliskova V; Gardlik R; Hodosy J; Celec P; Tothova L
+Authors Full Name
+ Conka, Jozef; Meliskova, Veronika; Gardlik, Roman; Hodosy, Julius; Celec, Peter; Tothova, Lubomira.
+Institution
+ Conka, Jozef. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
+ Meliskova, Veronika. Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
+ Gardlik, Roman. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
+ Hodosy, Julius. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
+ Celec, Peter. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.
+ Tothova, Lubomira. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia. Electronic address: lubomira.tothova@imbm.sk.
+MeSH Subject Headings
+ Animals
+ *Beverages
+ Biomarkers
+ Cystitis/et [Etiology]
+ *Cystitis/pc [Prevention & Control]
+ Dehydration
+ Energy Intake
+ Female
+ Glucose/me [Metabolism]
+ Humans
+ Kidney/mi [Microbiology]
+ Metabolic Syndrome
+ Mice
+ Obesity
+ Pyelonephritis/et [Etiology]
+ *Pyelonephritis/pc [Prevention & Control]
+ Risk
+ Sugars
+ *Sweetening Agents/pd [Pharmacology]
+ Urinary Tract Infections/et [Etiology]
+ *Urinary Tract Infections/pc [Prevention & Control]
+ Urination
+Keyword Heading
+ Cola
+ Cystitis
+ Sweetened beverages
+ Urination
+ Uropathogens
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Urinary tract infections (UTI) are among the most common bacterial infections. Drinking more liquids increases the frequency of urination and it is recommended as part of the prevention and/or management of UTI. The intake of sugar-sweetened beverages (SSB) is associated with obesity, diabetes and metabolic syndrome. However, cola and other SSB increase liquid intake and diuresis and could, thus, affect the risk of UTI and its complications. We hypothesize that intake of cola has a protective effect on UTI and pyelonephritis. Using an animal model of UTI, we have confirmed that dehydration with minimal urine output leads to higher bacterial counts in the kidneys in comparison to control mice (p=0.01). The intake of SSB increased liquid intake and thus also diuresis and decreased renal bacterial counts as a marker of induced pyelonephritis (p=0.036). The preliminary results show that dehydration is a risk factor for UTI and that higher diuresis induced by drinking SSB might be protective against pyelonephritis. The underlying mechanisms could include increased voiding frequency but potentially also active compounds in cola such as caffeine. These findings might have implications for the management of individuals at high risk of UTI. Further studies should verify the hypothesis and evaluate the practical relevance of this concept. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Sugars). 0 (Sweetening Agents). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.mehy.2019.04.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Conka&issn=0306-9877&title=Medical+Hypotheses&atitle=Beneficial+effect+of+sugar-sweetened+beverages+on+the+risk+of+urinary+tract+infections.&volume=127&issue=&spage=84&epage=87&date=2019&doi=10.1016%2Fj.mehy.2019.04.002&pmid=31088654&sid=OVID:medline
+
+<1669>
+Unique Identifier
+ 31086129
+Title
+ Association of Hair Cortisol Concentration with Prevalence of Major Cardiovascular Risk Factors and Allostatic Load.
+Source
+ Medical Science Monitor. 25:3573-3582, 2019 May 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mazgelyte E; Karciauskaite D; Linkeviciute A; Mazeikiene A; Burokiene N; Matuzeviciene R; Radzevicius M; Janiulioniene A; Jakaitiene A; Dindiene L; Kucinskiene ZA
+Authors Full Name
+ Mazgelyte, Egle; Karciauskaite, Dovile; Linkeviciute, Ausra; Mazeikiene, Asta; Burokiene, Neringa; Matuzeviciene, Reda; Radzevicius, Mantas; Janiulioniene, Ausra; Jakaitiene, Audrone; Dindiene, Lina; Kucinskiene, Zita Ausrele.
+Institution
+ Mazgelyte, Egle. Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
+ Karciauskaite, Dovile. Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
+ Linkeviciute, Ausra. Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
+ Mazeikiene, Asta. Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
+ Burokiene, Neringa. Clinics of Internal Diseases, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
+ Matuzeviciene, Reda. Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
+ Radzevicius, Mantas. Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
+ Janiulioniene, Ausra. Centre of Laboratory Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
+ Jakaitiene, Audrone. Department of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
+ Dindiene, Lina. Faculty of Mathematics and Natural Sciences, Kaunas University of Technology, Kaunas, Lithuania.
+ Kucinskiene, Zita Ausrele. Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Vilnius University, Vilnius, Lithuania.
+MeSH Subject Headings
+ Adult
+ Allostasis/ph [Physiology]
+ Anthropometry
+ Biomarkers
+ Body Mass Index
+ *Cardiovascular Diseases/et [Etiology]
+ Cholesterol, LDL/bl [Blood]
+ Dyslipidemias
+ Hair/ch [Chemistry]
+ Humans
+ *Hydrocortisone/an [Analysis]
+ Hypertension/co [Complications]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Prevalence
+ Risk Factors
+ Smoking
+ *Stress, Psychological/me [Metabolism]
+ Waist Circumference
+Abstract
+ BACKGROUND The high prevalence of cardiovascular diseases cannot be explained completely by conventional risk factors such as older age, smoking, diabetes mellitus, hypertension, obesity, and dyslipidemia. Results of recent studies indicate that chronic stress may be an independent risk factor for cardiovascular morbidity and mortality. Thus, the aim of our study was to investigate the associations between the hair cortisol concentration (HCC), which is considered as a potential biomarker of long-term psychosocial stress, and traditional cardiovascular risk factors, including smoking, dyslipidemia, hypertension, and obesity. MATERIAL AND METHODS Fasting blood samples and anthropometric and lifestyle data were collected from 163 apparently healthy men. HCC was determined using high-performance liquid chromatography. Allostatic load (AL) index, defined as an integrated score of multiple interacting systems involved in the adaptation to adverse physical or psychosocial situations, was also calculated. RESULTS We found that many prevalent cardiovascular risk factors, including hypertension, smoking, higher than recommended waist circumference (WC), and low-density lipoprotein cholesterol (LDL-C) median values, are associated with higher HCC. Hair cortisol level was also positively associated with the manifestation of individual cardiovascular risk factors such as higher-than-recommended total cholesterol, LDL-C, non-high-density lipoprotein cholesterol, body mass index, and WC median values. Moreover, a significant positive relationship between HCC and AL index was observed. CONCLUSIONS The results of this study suggest that increased prevalence of traditional cardiovascular risk factors is associated with higher HCC. Also, both HCC and AL index might be appropriate markers for the evaluation of chronic stress level.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.12659%2fMSM.913532
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mazgelyte&issn=1234-1010&title=Medical+Science+Monitor&atitle=Association+of+Hair+Cortisol+Concentration+with+Prevalence+of+Major+Cardiovascular+Risk+Factors+and+Allostatic+Load.&volume=25&issue=&spage=3573&epage=3582&date=2019&doi=10.12659%2FMSM.913532&pmid=31086129&sid=OVID:medline
+
+<1670>
+Unique Identifier
+ 31083422
+Title
+ White Adipose Tissue Response of Obese Mice to Ambient Oxygen Restriction at Thermoneutrality: Response Markers Identified, but no WAT Inflammation.
+Source
+ Genes (Basel). 10(5), 2019 05 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hoevenaars FPM; Keijer J; van der Stelt I; Duivenvoorde LPM; Herreman L; van Nes R; Friedecky D; Hegeman MA; van Schothorst EM
+Authors Full Name
+ Hoevenaars, Femke P M; Keijer, Jaap; van der Stelt, Inge; Duivenvoorde, Loes P M; Herreman, Laure; van Nes, Robin; Friedecky, David; Hegeman, Maria A; van Schothorst, Evert M.
+Institution
+ Hoevenaars, Femke P M. Human and Animal Physiology, Wageningen University, P.O. Box 338, Wageningen 6700 AH, The Netherlands. femke.hoevenaars@TNO.nl.
+ Keijer, Jaap. Human and Animal Physiology, Wageningen University, P.O. Box 338, Wageningen 6700 AH, The Netherlands. jaap.keijer@wur.nl.
+ van der Stelt, Inge. Human and Animal Physiology, Wageningen University, P.O. Box 338, Wageningen 6700 AH, The Netherlands. inge.vanderstelt@wur.nl.
+ Duivenvoorde, Loes P M. Human and Animal Physiology, Wageningen University, P.O. Box 338, Wageningen 6700 AH, The Netherlands. loes.duivenvoorde@wur.nl.
+ Herreman, Laure. Human and Animal Physiology, Wageningen University, P.O. Box 338, Wageningen 6700 AH, The Netherlands. laure.herreman@hotmail.fr.
+ van Nes, Robin. Human and Animal Physiology, Wageningen University, P.O. Box 338, Wageningen 6700 AH, The Netherlands. robinvannes@hotmail.com.
+ Friedecky, David. Laboratory of Metabolomics, Institute of Molecular and Translational Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic. david@friedecky.cz.
+ Hegeman, Maria A. Human and Animal Physiology, Wageningen University, P.O. Box 338, Wageningen 6700 AH, The Netherlands. m.a.hegeman@uu.nl.
+ van Schothorst, Evert M. Human and Animal Physiology, Wageningen University, P.O. Box 338, Wageningen 6700 AH, The Netherlands. evert.vanschothorst@wur.nl.
+ van Schothorst, Evert M. Current address: Educational Consultancy & Professional Development, Faculty of Social and Behavioural Sciences, Utrecht University, P.O. Box 80127, 3508 TC Utrecht, The Netherlands.. evert.vanschothorst@wur.nl.
+MeSH Subject Headings
+ Adipokines/ge [Genetics]
+ Adipokines/me [Metabolism]
+ *Adipose Tissue, White/me [Metabolism]
+ Adipose Tissue, White/pa [Pathology]
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat
+ Gene Expression Regulation
+ *Hypoxia/ge [Genetics]
+ Hypoxia/me [Metabolism]
+ Inflammation/ge [Genetics]
+ Inflammation/me [Metabolism]
+ Lactic Acid/me [Metabolism]
+ Male
+ Mice, Inbred C57BL
+ *Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Temperature
+Keyword Heading
+ adipokine
+ cholecystokinin
+ hypoxia
+ inflammation
+ white adipose tissue
+ whole genome microarray gene expression
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with white adipose tissue (WAT) hypoxia and inflammation. We aimed to test whether mild environmental oxygen restriction (OxR, 13% O2), imposing tissue hypoxia, triggers WAT inflammation in obese mice. Thirteen weeks diet-induced obese male adult C57BL/6JOlaHsd mice housed at thermoneutrality were exposed for five days to OxR versus normoxia. WAT and blood were isolated and used for analysis of metabolites and adipokines, WAT histology and macrophage staining, and WAT transcriptomics. OxR increased circulating levels of haemoglobin and haematocrit as well as hypoxia responsive transcripts in WAT and decreased blood glucose, indicating systemic and tissue hypoxia. WAT aconitase activity was inhibited. Macrophage infiltration as marker for WAT inflammation tended to be decreased, which was supported by down regulation of inflammatory genes S100a8, Ccl8, Clec9a, Saa3, Mgst2, and Saa1. Other down regulated processes include cytoskeleton remodelling and metabolism, while response to hypoxia appeared most prominently up regulated. The adipokines coiled-coil domain containing 3 (CCDC3) and adiponectin, as well as the putative WAT hormone cholecystokinin (CCK), were reduced by OxR on transcript (Cck, Ccdc3) and/or serum protein level (adiponectin, CCDC3). Conclusively, our data demonstrate that also in obese mice OxR does not trigger WAT inflammation. However, OxR does evoke a metabolic response in WAT, with CCDC3 and adiponectin as potential markers for systemic or WAT hypoxia.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 33X04XA5AT (Lactic Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fgenes10050359
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hoevenaars&issn=2073-4425&title=Genes+%28Basel%29&atitle=White+Adipose+Tissue+Response+of+Obese+Mice+to+Ambient+Oxygen+Restriction+at+Thermoneutrality%3A+Response+Markers+Identified%2C+but+no+WAT+Inflammation.&volume=10&issue=5&spage=&epage=&date=2019&doi=10.3390%2Fgenes10050359&pmid=31083422&sid=OVID:medline
+
+<1671>
+Unique Identifier
+ 31081756
+Title
+ Leptin as a predictor of anthropometric cutoff points for obesity.
+Source
+ Pakistan Journal of Pharmaceutical Sciences. 32(2):483-490, 2019 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hingorjo MR; Zehra S; Nadeem S; Qureshi MA
+Authors Full Name
+ Hingorjo, Mozaffer Rahim; Zehra, Sitwat; Nadeem, Shazia; Qureshi, Masood Anwar.
+Institution
+ Hingorjo, Mozaffer Rahim. Jinnah Medical & Dental College, Karachi, Pakistan.
+ Zehra, Sitwat. Dr. AQ Khan Institute of Biotechnology & Genetic Engineering, Karachi, Pakistan.
+ Nadeem, Shazia. Department of Physiology, Ziauddin University, Karachi, Pakistan.
+ Qureshi, Masood Anwar. Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Female
+ Humans
+ *Leptin/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ ROC Curve
+ Sensitivity and Specificity
+ Waist Circumference
+Abstract
+ This study was conducted to find the association between leptin and adiposity indices. Secondly, to identify optimal threshold of various anthropometric indices for obesity, as assessed by 75th percentile of leptin levels, within a clinic sample of non-diabetic and diabetic Pakistani adults. Fasting serum leptin levels were compared with anthropometric markers of obesity in 164 diabetic and non-diabetic subjects (90 male, 74 female), aged 35 to 65 years. Obesity was defined by body mass index (BMI) of 25 kg/m2 in either sex. The cutoff point of leptin was taken as the 75th percentile in non-obese subjects. Diagnostic accuracy for detecting excess fatness was evaluated through receiver operating characteristics (ROC) analyses with leptin taken as reference test against anthropometric indices as test variables. The 75th percentile of leptin in male and female was 7.0ng/mL and 17.9ng/mL, respectively. Leptin levels were significantly higher in females (p<0.001) and had strong positive correlation (p<0.001) with most anthropometric indices of obesity in both sexes; hip circumference (HC) being most prominent among these. Largest area under ROC curve (AUC) was between WC and leptin (AUC=0.844; CI=0.764, 0.925) in males and BMI and leptin (AUC=0.832; CI=0.740, 0.923) in females. The optimum thresholds for obesity indices in our study were: BMI, WC and HC as 25 kg/m2, 96.25cm, 99.25cm for males; 27 kg/m2, 95.50cm, 105.5cm for females, respectively. Leptin can be considered as a potential marker of obesity and may be used to identify obesity cutoffs in future demographic surveys. Longitudinal studies are required that include leptin in coronary artery disease risk assessment models.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (LEP protein, human). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&AN=31081756
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hingorjo&issn=1011-601X&title=Pakistan+Journal+of+Pharmaceutical+Sciences&atitle=Leptin+as+a+predictor+of+anthropometric+cutoff+points+for+obesity.&volume=32&issue=2&spage=483&epage=490&date=2019&doi=&pmid=31081756&sid=OVID:medline
+
+<1672>
+Unique Identifier
+ 31080589
+Title
+ Addition of milk fat globule membrane-enriched supplement to a high-fat meal attenuates insulin secretion and induction of soluble epoxide hydrolase gene expression in the postprandial state in overweight and obese subjects.
+Source
+ Journal of Nutritional Science. 8:e16, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Beals E; Kamita SG; Sacchi R; Demmer E; Rivera N; Rogers-Soeder TS; Gertz ER; Van Loan MD; German JB; Hammock BD; Smilowitz JT; Zivkovic AM
+Author NameID
+ Beals, Elizabeth; ORCID: https://orcid.org/0000-0002-3223-9345
+Authors Full Name
+ Beals, Elizabeth; Kamita, S G; Sacchi, R; Demmer, E; Rivera, N; Rogers-Soeder, T S; Gertz, E R; Van Loan, M D; German, J B; Hammock, B D; Smilowitz, J T; Zivkovic, A M.
+Institution
+ Beals, Elizabeth. Department of Nutrition, University of California, Davis, CA, USA.
+ Kamita, S G. Department of Entomology, University of California, Davis, CA, USA.
+ Sacchi, R. Department of Nutrition, University of California, Davis, CA, USA.
+ Demmer, E. Department of Nutrition, University of California, Davis, CA, USA.
+ Rivera, N. Department of Nutrition, University of California, Davis, CA, USA.
+ Rogers-Soeder, T S. Department of Nutrition, University of California, Davis, CA, USA.
+ Gertz, E R. US Department of Agriculture/Agricultural Research Service Western Human Nutrition Research Center, Davis, CA, USA.
+ Van Loan, M D. Department of Nutrition, University of California, Davis, CA, USA.
+ Van Loan, M D. US Department of Agriculture/Agricultural Research Service Western Human Nutrition Research Center, Davis, CA, USA.
+ German, J B. Foods for Health Institute, University of California, Davis, CA, USA.
+ German, J B. Department of Food Science & Technology, University of California, Davis, CA, USA.
+ Hammock, B D. Department of Entomology, University of California, Davis, CA, USA.
+ Smilowitz, J T. Foods for Health Institute, University of California, Davis, CA, USA.
+ Smilowitz, J T. Department of Food Science & Technology, University of California, Davis, CA, USA.
+ Zivkovic, A M. Department of Nutrition, University of California, Davis, CA, USA.
+ Zivkovic, A M. Foods for Health Institute, University of California, Davis, CA, USA.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Cholesterol/bl [Blood]
+ Cytokines/me [Metabolism]
+ Dairy Products
+ Diet
+ *Dietary Supplements
+ Epoxide Hydrolases/ge [Genetics]
+ Epoxide Hydrolases/me [Metabolism]
+ Fasting
+ Fatty Acids
+ Female
+ *Gene Expression/de [Drug Effects]
+ *Glycolipids/me [Metabolism]
+ Glycolipids/pd [Pharmacology]
+ *Glycoproteins/me [Metabolism]
+ Glycoproteins/pd [Pharmacology]
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Secretion/de [Drug Effects]
+ Interleukin-6/me [Metabolism]
+ Lipid Droplets
+ Male
+ *Meals
+ Membranes/ch [Chemistry]
+ Metabolic Syndrome
+ Middle Aged
+ *Obesity/me [Metabolism]
+ *Overweight/me [Metabolism]
+ *Postprandial Period/de [Drug Effects]
+ Young Adult
+Keyword Heading
+ ARA, arachidonic acid
+ CD14, cluster of differentiation 14
+ CRP, C-reactive protein
+ Chol:HDL, cholesterol:HDL-cholesterol ratio
+ Cytokines
+ EPHX2, soluble epoxide hydrolase
+ Inflammatory markers
+ LBP, lipopolysaccharide binding protein
+ LPS, lipopolysaccharide
+ LTBR, lymphotoxin beta receptor
+ MFGM, milk fat globule membrane
+ MetS, metabolic syndrome
+ Metabolic syndrome
+ Milk fat globule membrane
+ Overweight
+ Postprandial inflammation
+ SAA, serum amyloid A
+ Saturated fat
+ T2DM, type 2 diabetes mellitus
+ WC, whipping cream
+ iAUC, incremental AUC
+ sEH, soluble epoxide hydrolase
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CVD and associated metabolic diseases are linked to chronic inflammation, which can be modified by diet. The objective of the present study was to determine whether there is a difference in inflammatory markers, blood metabolic and lipid panels and lymphocyte gene expression in response to a high-fat dairy food challenge with or without milk fat globule membrane (MFGM). Participants consumed a dairy product-based meal containing whipping cream (WC) high in saturated fat with or without the addition of MFGM, following a 12 h fasting blood draw. Inflammatory markers including IL-6 and C-reactive protein, lipid and metabolic panels and lymphocyte gene expression fold changes were measured using multiplex assays, clinical laboratory services and TaqMan real-time RT-PCR, respectively. Fold changes in gene expression were determined using the Pfaffl method. Response variables were converted into incremental AUC, tested for differences, and corrected for multiple comparisons. The postprandial insulin response was significantly lower following the meal containing MFGM (P < 0.01). The gene encoding soluble epoxide hydrolase (EPHX2) was shown to be more up-regulated in the absence of MFGM (P = 0.009). Secondary analyses showed that participants with higher baseline cholesterol:HDL-cholesterol ratio (Chol:HDL) had a greater reduction in gene expression of cluster of differentiation 14 (CD14) and lymphotoxin beta receptor (LTBR) with the WC+MFGM meal. The protein and lipid composition of MFGM is thought to be anti-inflammatory. These exploratory analyses suggest that addition of MFGM to a high-saturated fat meal modifies postprandial insulin response and offers a protective role for those individuals with higher baseline Chol:HDL.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Fatty Acids). 0 (Glycolipids). 0 (Glycoproteins). 0 (Insulin). 0 (Interleukin-6). 0 (milk fat globule). 9007-41-4 (C-Reactive Protein). 97C5T2UQ7J (Cholesterol). EC 3-3-2 (Epoxide Hydrolases). EC 3-3-2-10 (EPHX2 protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1017%2fjns.2019.11
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Beals&issn=2048-6790&title=Journal+of+Nutritional+Science&atitle=Addition+of+milk+fat+globule+membrane-enriched+supplement+to+a+high-fat+meal+attenuates+insulin+secretion+and+induction+of+soluble+epoxide+hydrolase+gene+expression+in+the+postprandial+state+in+overweight+and+obese+subjects.&volume=8&issue=&spage=e16&epage=&date=2019&doi=10.1017%2Fjns.2019.11&pmid=31080589&sid=OVID:medline
+
+<1673>
+Unique Identifier
+ 31077211
+Title
+ Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population.
+Source
+ Lipids in Health & Disease. 18(1):111, 2019 May 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Teng MS; Wu S; Hsu LA; Tzeng IS; Chou HH; Su CW; Ko YL
+Author NameID
+ Ko, Yu-Lin; ORCID: http://orcid.org/0000-0002-8218-6827
+Authors Full Name
+ Teng, Ming-Sheng; Wu, Semon; Hsu, Lung-An; Tzeng, I-Shiang; Chou, Hsin-Hua; Su, Cheng-Wen; Ko, Yu-Lin.
+Institution
+ Teng, Ming-Sheng. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city, Taiwan.
+ Wu, Semon. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city, Taiwan.
+ Wu, Semon. Department of Life Science, Chinese Culture University, Taipei, Taiwan.
+ Hsu, Lung-An. The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
+ Tzeng, I-Shiang. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city, Taiwan.
+ Chou, Hsin-Hua. The Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city, Taiwan.
+ Su, Cheng-Wen. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city, Taiwan.
+ Ko, Yu-Lin. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city, Taiwan. yulinkotw@yahoo.com.tw.
+ Ko, Yu-Lin. The Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city, Taiwan. yulinkotw@yahoo.com.tw.
+ Ko, Yu-Lin. School of Medicine, Tzu Chi University, Hualien, Taiwan. yulinkotw@yahoo.com.tw.
+MeSH Subject Headings
+ 8-Hydroxy-2'-Deoxyguanosine
+ Biomarkers/bl [Blood]
+ Cholesterol, HDL/bl [Blood]
+ *Deoxyguanosine/aa [Analogs & Derivatives]
+ Deoxyguanosine/ur [Urine]
+ Female
+ *Genetic Association Studies
+ *Genetic Pleiotropy
+ Humans
+ *Lipase/ge [Genetics]
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Models, Biological
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ *Polymorphism, Single Nucleotide/ge [Genetics]
+ Sex Characteristics
+ Triglycerides/bl [Blood]
+Keyword Heading
+ Hepatic lipase
+ High-density lipoprotein cholesterol level
+ Mediation analysis
+ Single-nucleotide polymorphism
+ Suppression effect
+ Triglyceride level
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hepatic lipase (HL, encoded by LIPC) is a glycoprotein primarily synthesized and secreted by hepatocytes. Previous studies had demonstrated that HL is crucial for reverse cholesterol transport and affects the metabolism, composition, and level of several lipoproteins. In current study, we investigated the association of LIPC (Lipase C, Hepatic Type) variants with circulating and urinary biomarker levels by using subgroup and mediation analyses.
+
+ METHODS: A total of 572 participants from Taiwan were genotyped for three LIPC single nucleotide polymorphisms (SNPs) by using TaqMan assay. Fasting levels of glucose, lipid profile, inflammation markers, urine creatinine and 8-hydroxy deoxyguanosine (8-OHdG) were measured. The chi-square test, 2-sample t test and Analysis of variance (ANOVA) were used to examine differences among variables and genotype frequencies.
+
+ RESULTS: SNPs rs2043085 and rs1532085 were significantly associated with urinary 8-OHdG levels, whereas all three SNPs were more significantly associated with Triglycerides (TG) or HDL-cholesterol (HDL-C) levels after additional adjustment for HDL-C or TG levels, respectively. Subgroup analyses revealed that the association of the LIPC SNPs with the levels of serum TG, HDL-C, and urinary 8-OHdG were predominantly observed in the men but not in the women. Differential associations of the LIPC SNPs with various lipid levels were observed in participants with different adiposity statuses. Mediation analyses indicated that TG levels acted as a suppressor masking the association of the LIPC genotypes with HDL-C levels, particularly in the men (Sobel test, all P < 0.01).
+
+ CONCLUSION: Our data revealed that interaction and suppression effects mediated the pleiotropic association of the LIPC variants. The effects of the LIPC SNPs depended on sex, adiposity status, and TG levels. Thus, our findings can provide a method for identifying high-risk populations of cardiovascular diseases for clinical diagnosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (LIPC protein, human). 0 (Lipids). 0 (Triglycerides). 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine). EC 3-1-1-3 (Lipase). G9481N71RO (Deoxyguanosine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12944-019-1057-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Teng&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Pleiotropic+association+of+LIPC+variants+with+lipid+and+urinary+8-hydroxy+deoxyguanosine+levels+in+a+Taiwanese+population.&volume=18&issue=1&spage=111&epage=&date=2019&doi=10.1186%2Fs12944-019-1057-9&pmid=31077211&sid=OVID:medline
+
+<1674>
+Unique Identifier
+ 31075797
+Title
+ Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity.
+Source
+ Hormone & Metabolic Research. 51(6):389-395, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Caimi G; Canino B; Montana M; Urso C; Calandrino V; Presti RL; Hopps E
+Authors Full Name
+ Caimi, Gregorio; Canino, Baldassare; Montana, Maria; Urso, Caterina; Calandrino, Vincenzo; Presti, Rosalia Lo; Hopps, Eugenia.
+Institution
+ Caimi, Gregorio. Dipartimento Biomedico di Medicina Interna e Specialistica, Universita di Palermo, Palermo, Italy.
+ Canino, Baldassare. Dipartimento Biomedico di Medicina Interna e Specialistica, Universita di Palermo, Palermo, Italy.
+ Montana, Maria. Dipartimento Biomedico di Medicina Interna e Specialistica, Universita di Palermo, Palermo, Italy.
+ Urso, Caterina. Dipartimento Biomedico di Medicina Interna e Specialistica, Universita di Palermo, Palermo, Italy.
+ Calandrino, Vincenzo. Dipartimento Biomedico di Medicina Interna e Specialistica, Universita di Palermo, Palermo, Italy.
+ Presti, Rosalia Lo. Dipartimento di Scienze Psicologiche, Pedagogiche, dell'Esercizio Fisico e della Formazione, Universita di Palermo, Palermo, Italy.
+ Hopps, Eugenia. Dipartimento Biomedico di Medicina Interna e Specialistica, Universita di Palermo, Palermo, Italy.
+MeSH Subject Headings
+ Adult
+ Biomarkers/an [Analysis]
+ Case-Control Studies
+ Female
+ Humans
+ *Lipid Peroxidation
+ Male
+ *Matrix Metalloproteinase 2/bl [Blood]
+ *Matrix Metalloproteinase 9/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Oxidation-Reduction
+ Oxidative Stress
+ *Proteins/ch [Chemistry]
+ Proteolysis
+ *Tissue Inhibitor of Metalloproteinase-1/bl [Blood]
+ *Tissue Inhibitor of Metalloproteinase-2/bl [Blood]
+Abstract
+ The association between obesity and cardiovascular diseases has a multifactorial pathogenesis, including the synthesis of inflammatory molecules, the increase in oxidative stress and the dysregulation of the matrix metalloprotease (MMP) concentration and activity. In a group of adults with obesity, divided in 2 subgroups according to the body mass index (BMI), we examined lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), protein oxidation, expressed as protein carbonyl groups (PCs), plasma gelatinases (MMP-2 and MMP-9), and their tissue inhibitors (TIMP-1 and TIMP-2). In the whole group, as well as in the 2 subgroups (with BMI 30-35 or BMI>35) of obese subjects, we observed an increase in TBARS, PCs, MMP-2, and MMP-9, and also TIMP-1 and TIMP-2 in comparison with the control group. A positive correlation between TBARS and PCs emerged in obese subjects and persisted after dividing obese subjects according to BMI. The correlation between MMP-2 and TIMP-2 was not statistically significant, while a significant correlation was present between MMP-9 and TIMP-1. The correlations between the markers of oxidative stress (TBARS and PCs) and those of the MMP/TIMP profile indicated a more marked influence of protein oxidation on MMPs and TIMPs in comparison with TBARS. The innovative aspect of our study was the simultaneous evaluation of oxidative stress markers and MMP/TIMP profile in adult obese subjects. We observed significant alterations and correlations that may negatively influence the clinical course of the disease. Copyright © Georg Thieme Verlag KG Stuttgart . New York.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteins). 0 (TIMP1 protein, human). 0 (TIMP2 protein, human). 0 (Tissue Inhibitor of Metalloproteinase-1). 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2). EC 3-4-24-24 (MMP2 protein, human). EC 3-4-24-24 (Matrix Metalloproteinase 2). EC 3-4-24-35 (MMP9 protein, human). EC 3-4-24-35 (Matrix Metalloproteinase 9).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1055%2fa-0887-2770
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Caimi&issn=0018-5043&title=Hormone+%26+Metabolic+Research&atitle=Lipid+Peroxidation%2C+Protein+Oxidation%2C+Gelatinases%2C+and+Their+Inhibitors+in+a+Group+of+Adults+with+Obesity.&volume=51&issue=6&spage=389&epage=395&date=2019&doi=10.1055%2Fa-0887-2770&pmid=31075797&sid=OVID:medline
+
+<1675>
+Unique Identifier
+ 31072410
+Title
+ Absence of BBSome function leads to astrocyte reactivity in the brain.
+Source
+ Molecular Brain. 12(1):48, 2019 05 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Singh M; Garrison JE; Wang K; Sheffield VC
+Author NameID
+ Singh, Minati; ORCID: https://orcid.org/0000-0001-7307-2628
+Authors Full Name
+ Singh, Minati; Garrison, Janelle E; Wang, Kai; Sheffield, Val C.
+Institution
+ Singh, Minati. Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA. minati-singh@uiowa.edu.
+ Garrison, Janelle E. Departments of Pediatrics and Ophthalmology, University of Iowa, Iowa City, IA, 52242, USA.
+ Wang, Kai. Department of Biostatistics, University of Iowa, Iowa City, IA, 52242, USA.
+ Sheffield, Val C. Departments of Pediatrics and Ophthalmology, University of Iowa, Iowa City, IA, 52242, USA. val-sheffield@uiowa.edu.
+MeSH Subject Headings
+ Animals
+ *Astrocytes/me [Metabolism]
+ *Astrocytes/pa [Pathology]
+ *Bardet-Biedl Syndrome/me [Metabolism]
+ *Bardet-Biedl Syndrome/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ Body Weight
+ *Brain/pa [Pathology]
+ Cytoskeletal Proteins/me [Metabolism]
+ Disease Models, Animal
+ Gene Expression Regulation
+ Glial Fibrillary Acidic Protein/me [Metabolism]
+ Hydrocephalus/pa [Pathology]
+ Inflammation Mediators/me [Metabolism]
+ Interleukin-1beta/me [Metabolism]
+ Interleukin-6/ge [Genetics]
+ Interleukin-6/me [Metabolism]
+ Mice
+ Microglia/me [Metabolism]
+ Microglia/pa [Pathology]
+ Obesity/pa [Pathology]
+ Post-Synaptic Density/me [Metabolism]
+ RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+Keyword Heading
+ And microglia
+ BBS
+ Neuroinflammation
+ Reactive astrocytes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In humans, dysfunctional primary cilia result in Bardet-Biedl syndrome (BBS), which presents with clinical features including intellectual disabilities, obesity, and retinal degeneration, and, in mouse models, the added feature of hydrocephalus. We observed increased Glial Fibrillary Acidic Protein (GFAP) immunoreactivity in BBS mouse brains. Increased GFAP expression is a hallmark of astrocyte reactivity that is associated with microglia activation and neuro-inflammation. To gain a better understanding of reactive astrocytes observed in BBS mice, we used two mouse models of BBS8, a BBSome protein, to characterize the reactive astrocyte phenotype. The finding of reactive astrocytes in young BBS mouse brains led us to hypothesize that loss of BBSome function leads to reactive astrocytes prior to hydrocephalus and obesity. By using two mouse models of BBS8, a congenital BBS8 knockout with hydrocephalus, and a tamoxifen-inducible BBS8 knockout without hydrocephalus, we were able to molecularly phenotype the reactive astrocytes. Molecular phenotype of reactive astrocytes shows differential regulation of inducers of Pan, A1 neurotoxic, and A2 neuroprotective astrocytes that are significantly altered in brains of both congenital and induced knockouts of BBS8, but without microglia activation. We find evidence for neuroinflammation in the brains of congenital knockout mice, but not in induced knockout mice. Protein levels of GFAP, SERPINA3N and post-synaptic density 95 (PSD95) are significantly increased in congenital knockout mice, but remain unchanged in induced knockout mice. Thus, despite the reactive astrocyte phenotype being present in both models, the molecular signature of reactive astrocytes in BBS8 mice models are distinct. Together, these findings suggest that BBS8, and by extension the BBSome, plays a role in neuro-astrocyte functions independent of hydrocephalus, and its dysregulation is associated with astrocyte reactivity without microglia activation. (Total word count 278).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytoskeletal Proteins). 0 (Glial Fibrillary Acidic Protein). 0 (Inflammation Mediators). 0 (Interleukin-1beta). 0 (Interleukin-6). 0 (RNA, Messenger). 0 (Ttc8 protein, mouse).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs13041-019-0466-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Singh&issn=1756-6606&title=Molecular+Brain&atitle=Absence+of+BBSome+function+leads+to+astrocyte+reactivity+in+the+brain.&volume=12&issue=1&spage=48&epage=&date=2019&doi=10.1186%2Fs13041-019-0466-z&pmid=31072410&sid=OVID:medline
+
+<1676>
+Unique Identifier
+ 31065382
+Title
+ Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent. [Review]
+Source
+ Journal of Obesity. 2019:6561726, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Maalouf GE; El Khoury D
+Author NameID
+ El Khoury, Diala; ORCID: https://orcid.org/0000-0003-3199-8558
+Authors Full Name
+ Maalouf, George-Emmanuel; El Khoury, Diala.
+Institution
+ Maalouf, George-Emmanuel. Department of Sciences, Notre Dame University-Louaize, P.O. Box 72, Zouk Mikael, Lebanon.
+ El Khoury, Diala. Department of Sciences, Notre Dame University-Louaize, P.O. Box 72, Zouk Mikael, Lebanon.
+MeSH Subject Headings
+ Adipogenesis
+ Adipose Tissue, Brown/ph [Physiology]
+ Adipose Tissue, White/ph [Physiology]
+ Biomarkers/me [Metabolism]
+ *Energy Metabolism/ph [Physiology]
+ *Exercise/ph [Physiology]
+ *Fibronectins/me [Metabolism]
+ Humans
+ Metabolic Diseases/me [Metabolism]
+ *Metabolic Diseases/pp [Physiopathology]
+ Metabolic Diseases/pc [Prevention & Control]
+ Muscle Contraction
+ *Muscle, Skeletal/me [Metabolism]
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Obesity/pc [Prevention & Control]
+ Thermogenesis/ph [Physiology]
+Abstract
+ Irisin is a recently discovered myokine that plays an important role in fat metabolism through the browning of white adipose tissue. This myokine is usually secreted after exercise by improving energy balance and has shown great potential as a possible treatment for some metabolic diseases such as obesity, insulin resistance, and inflammation. Obesity has been linked to a higher incidence of some cancers. Furthermore, some studies have shown irisin to have direct positive effects on different types of cancers. Although it is hard to relay conclusions from in vitro to in vivo studies, the majority of the available data favor irisin as a potential substance for cancer regression through reducing proinflammatory markers linked to obesity. However, some controversies remain on the exact benefits of irisin on cancer with some studies showing no or even a negative effect of irisin on cancer. This review summarizes these 2 differing viewpoints and synthesizes them to form a clearer picture of exercise-induced irisin's effects on cancer.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FNDC5 protein, human). 0 (Fibronectins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f6561726
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Maalouf&issn=2090-0708&title=Journal+of+Obesity&atitle=Exercise-Induced+Irisin%2C+the+Fat+Browning+Myokine%2C+as+a+Potential+Anticancer+Agent.&volume=2019&issue=&spage=6561726&epage=&date=2019&doi=10.1155%2F2019%2F6561726&pmid=31065382&sid=OVID:medline
+
+<1677>
+Unique Identifier
+ 31064976
+Title
+ Myalgia with Elevated Inflammatory Markers in an Obese Young Female: Fibromyalgia or Polymyalgia Rheumatica?.
+Source
+ The American Journal of Case Reports. 20:659-663, 2019 May 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cheema R; Chang-Miller A; Aslam F
+Authors Full Name
+ Cheema, Rabia; Chang-Miller, April; Aslam, Fawad.
+Institution
+ Cheema, Rabia. Department of Medicine, St. Mary's Hospital, Waterbury, CT, USA.
+ Cheema, Rabia. Department of Medicine, Frank H. Netter MD School of Medicine, North Haven, CT, USA.
+ Chang-Miller, April. Division of Rheumatology, Mayo Clinic, Scottsdale, AZ, USA.
+ Aslam, Fawad. Division of Rheumatology, Mayo Clinic, Scottsdale, AZ, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Sedimentation
+ *C-Reactive Protein/an [Analysis]
+ Diagnostic Errors
+ Female
+ Fibromyalgia/bl [Blood]
+ *Fibromyalgia/di [Diagnosis]
+ Humans
+ Myalgia/co [Complications]
+ *Myalgia/et [Etiology]
+ *Obesity/co [Complications]
+ Polymyalgia Rheumatica/bl [Blood]
+ Polymyalgia Rheumatica/di [Diagnosis]
+Abstract
+ BACKGROUND Fibromyalgia (FM) is a common disorder of diffuse musculoskeletal pain. It is distinctly different from polymyalgia rheumatica (PMR), a disease seen in people over the age of 50 years. Hallmark features of PMR are the presence of elevated erythrocytes sedimentation rate (ESR) and/or C-reactive protein (CRP). These markers are normal in FM. Obesity in itself can be associated with elevated CRP and ESR, and when obese patients present with myalgia and elevated inflammatory markers, diagnostic confusion can ensue. CASE REPORT We describe a case of 38-year-old female with diffuse musculoskeletal pain and elevated ESR and CRP who was initially misdiagnosed with PMR and responded partially to steroids. She developed severe adverse effects from chronic steroid use. She was ultimately diagnosed with FM. CONCLUSIONS We highlight features to help clinicians avoid the pitfall of diagnosing PMR in young obese patients with FM and elevated inflammatory markers. In this case report, we discuss the features of FM, PMR, PMR-like symptoms presentation, and the association of obesity with elevated inflammatory markers.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Case Reports. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.12659%2fAJCR.915564
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cheema&issn=1941-5923&title=The+American+Journal+of+Case+Reports&atitle=Myalgia+with+Elevated+Inflammatory+Markers+in+an+Obese+Young+Female%3A+Fibromyalgia+or+Polymyalgia+Rheumatica%3F.&volume=20&issue=&spage=659&epage=663&date=2019&doi=10.12659%2FAJCR.915564&pmid=31064976&sid=OVID:medline
+
+<1678>
+Unique Identifier
+ 31059027
+Title
+ A novel resveratrol analog PA19 attenuates obesity-induced cardiac and renal injury by inhibiting inflammation and inflammatory cell infiltration.
+Source
+ Molecular Medicine Reports. 19(6):4770-4778, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang W; Chen H; Sun C; Wu B; Bai B; Liu H; Shan X; Liang G; Zhang Y
+Authors Full Name
+ Zhang, Wenxin; Chen, Hongjin; Sun, Chuchu; Wu, Beibei; Bai, Bin; Liu, Hui; Shan, Xiaoou; Liang, Guang; Zhang, Yali.
+Institution
+ Zhang, Wenxin. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
+ Chen, Hongjin. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
+ Sun, Chuchu. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
+ Wu, Beibei. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
+ Bai, Bin. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
+ Liu, Hui. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
+ Shan, Xiaoou. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
+ Liang, Guang. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
+ Zhang, Yali. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
+MeSH Subject Headings
+ Animals
+ Anti-Inflammatory Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Diet, High-Fat
+ Fibrosis/dt [Drug Therapy]
+ Fibrosis/pa [Pathology]
+ Heart
+ *Heart Injuries/dt [Drug Therapy]
+ Heart Injuries/pa [Pathology]
+ *Inflammation/dt [Drug Therapy]
+ Inflammation/pa [Pathology]
+ *Kidney/de [Drug Effects]
+ Kidney/in [Injuries]
+ Kidney/pa [Pathology]
+ Kidney Diseases/dt [Drug Therapy]
+ Kidney Diseases/pa [Pathology]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ *Obesity/me [Metabolism]
+ *Resveratrol/aa [Analogs & Derivatives]
+ Resveratrol/ch [Chemistry]
+Abstract
+ Obesity is a major global health concern and induces numerous complications, such as heart and kidney injury. Inflammation is an important pathogenic mechanism underlying obesity-associated tissue injury. (1E,4E)-1-{2,4-Dimethoxy-6-[(E)-4-methoxystyryl]phenyl}-5- (2,4-dimethoxyphenyl)penta-1,4-dien-3-one (PA19) is a novel anti-inflammatory compound synthesized by our research group. In the present study, the efficacy of PA19 in attenuating high-fat diet (HFD)-induced heart and kidney injury was investigated. Heart and kidney pathological injury and fibrosis were detected by hematoxylin and eosin and Sirius red staining, respectively. The expression levels of inflammatory genes and fibrosis-associated protein were determined by reverse transcription-quantitative polymerase chain reaction and western blotting. ELISA was used to detect the level of inflammatory cytokines. Following 20 weeks of HFD treatment, mice exhibited increased lipid accumulation in the serum, heart and kidney injury and fibrosis, and inflammation and inflammatory cell infiltration compared with mice fed a control diet. Conversely, treatment with PA19 during the final 12 weeks of the study significantly reduced the degree of heart and kidney fibrosis and inflammation induced by HFD. The results suggested that PA19 attenuates heart and kidney inflammation and injury induced by HFD, and indicated that PA19 may be a novel therapeutic agent in the treatment of obesity, and obesity-induced cardiac and renal injury.
+Registry Number/Name of Substance
+ 0 (Anti-Inflammatory Agents). 0 (Biomarkers). Q369O8926L (Resveratrol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3892%2fmmr.2019.10157
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1791-2997&title=Molecular+Medicine+Reports&atitle=A+novel+resveratrol+analog+PA19+attenuates+obesity-induced+cardiac+and+renal+injury+by+inhibiting+inflammation+and+inflammatory+cell+infiltration.&volume=19&issue=6&spage=4770&epage=4778&date=2019&doi=10.3892%2Fmmr.2019.10157&pmid=31059027&sid=OVID:medline
+
+<1679>
+Unique Identifier
+ 31057549
+Title
+ Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. [Review]
+Source
+ Frontiers in Immunology. 10:826, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cameron GJM; Cautivo KM; Loering S; Jiang SH; Deshpande AV; Foster PS; McKenzie ANJ; Molofsky AB; Hansbro PM; Starkey MR
+Authors Full Name
+ Cameron, Guy J M; Cautivo, Kelly M; Loering, Svenja; Jiang, Simon H; Deshpande, Aniruddh V; Foster, Paul S; McKenzie, Andrew N J; Molofsky, Ari B; Hansbro, Philip M; Starkey, Malcolm R.
+Institution
+ Cameron, Guy J M. Priority Research Centre's GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
+ Cameron, Guy J M. Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
+ Cautivo, Kelly M. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, United States.
+ Loering, Svenja. Priority Research Centre's GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
+ Loering, Svenja. Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
+ Jiang, Simon H. Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australia National University, Canberra, ACT, Australia.
+ Jiang, Simon H. Department of Renal Medicine, The Canberra Hospital, Canberra, ACT, Australia.
+ Deshpande, Aniruddh V. Priority Research Centre's GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
+ Deshpande, Aniruddh V. Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
+ Deshpande, Aniruddh V. The John Hunter Children's Hospital, New Lambton Heights, NSW, Australia.
+ Foster, Paul S. Priority Research Centre's GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
+ Foster, Paul S. Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
+ McKenzie, Andrew N J. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, United Kingdom.
+ Molofsky, Ari B. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, United States.
+ Hansbro, Philip M. Priority Research Centre's GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
+ Hansbro, Philip M. Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
+ Hansbro, Philip M. Centre for inflammation, Centenary Institute, Sydney, NSW, Australia.
+ Hansbro, Philip M. Faculty of Science, University of Technology, Ultimo, NSW, Australia.
+ Starkey, Malcolm R. Priority Research Centre's GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
+ Starkey, Malcolm R. Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
+MeSH Subject Headings
+ *Acute Kidney Injury/im [Immunology]
+ Animals
+ Biomarkers
+ Disease Susceptibility/im [Immunology]
+ Humans
+ *Kidney/im [Immunology]
+ *Lymphocytes/im [Immunology]
+ Obesity/co [Complications]
+ *Reperfusion Injury/im [Immunology]
+ Respiratory Tract Diseases/im [Immunology]
+Keyword Heading
+ IL-13
+ IL-5
+ ILC2
+ IRI
+ group 2 innate lymphoid cell
+ ischemia-reperfusion injury
+ kidney
+ renal
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease. Group 2 innate lymphoid cells (ILC2s) are innate producers of type-2 cytokines and are critical regulators of homeostasis in peripheral organs. However, our knowledge of their function in the kidney is relatively limited. Recent evidence suggests that increasing ILC2 numbers by systemic administration of recombinant interleukin (IL)-25 or IL-33 protects against renal injury. Whilst ILC2s can be induced to protect against ischemic- or chemical-induced AKI, the impact of ILC2 deficiency or depletion on the severity of renal injury is unknown. Firstly, the phenotype and location of ILC2s in the kidney was assessed under homeostatic conditions. Kidney ILC2s constitutively expressed high levels of IL-5 and were located in close proximity to the renal vasculature. To test the functional role of ILC2s in the kidney, an experimental model of renal ischemia-reperfusion injury (IRI) was used and the severity of injury was assessed in wild-type, ILC2-reduced, ILC2-deficient, and ILC2-depleted mice. Surprisingly, there were no differences in histopathology, collagen deposition or mRNA expression of injury-associated (Lcn2), inflammatory (Cxcl1, Cxcl2, and Tnf) or extracellular matrix (Col1a1, Fn1) factors following IRI in the absence of ILC2s. These data suggest the absence of ILC2s does not alter the severity of renal injury, suggesting possible redundancy. Therefore, other mechanisms of type 2-mediated immune cell activation likely compensate in the absence of ILC2s. Hence, a loss of ILC2s is unlikely to increase susceptibility to, or severity of AKI.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3389%2ffimmu.2019.00826
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cameron&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Group+2+Innate+Lymphoid+Cells+Are+Redundant+in+Experimental+Renal+Ischemia-Reperfusion+Injury.&volume=10&issue=&spage=826&epage=&date=2019&doi=10.3389%2Ffimmu.2019.00826&pmid=31057549&sid=OVID:medline
+
+<1680>
+Unique Identifier
+ 31057014
+Title
+ Renal injury in obese children.
+Source
+ Renal Failure. 41(1):340, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kawada T
+Author NameID
+ Kawada, Tomoyuki; ORCID: https://orcid.org/0000-0002-4426-4644
+Authors Full Name
+ Kawada, Tomoyuki.
+Institution
+ Kawada, Tomoyuki. a Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo, 113-8602, Japan.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Biomarkers
+ Child
+ Humans
+ *Kidney
+ *Obesity
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Letter. Comment.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f0886022X.2019.1603111
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kawada&issn=0886-022X&title=Renal+Failure&atitle=Renal+injury+in+obese+children.&volume=41&issue=1&spage=340&epage=&date=2019&doi=10.1080%2F0886022X.2019.1603111&pmid=31057014&sid=OVID:medline
+
+<1681>
+Unique Identifier
+ 31056236
+Title
+ Association of Daily Rest-Activity Patterns With Adiposity and Cardiometabolic Risk Measures in Teens.
+Source
+ Journal of Adolescent Health. 65(2):224-231, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Quante M; Cespedes Feliciano EM; Rifas-Shiman SL; Mariani S; Kaplan ER; Rueschman M; Oken E; Taveras EM; Redline S
+Authors Full Name
+ Quante, Mirja; Cespedes Feliciano, Elizabeth M; Rifas-Shiman, Sheryl L; Mariani, Sara; Kaplan, Emily R; Rueschman, Michael; Oken, Emily; Taveras, Elsie M; Redline, Susan.
+Institution
+ Quante, Mirja. Department of Neonatology, University of Tuebingen, Tuebingen, Germany; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, Massachusetts. Electronic address: mirja.quante@med.uni-tuebingen.de.
+ Cespedes Feliciano, Elizabeth M. Division of Research, Kaiser Permanente Northern California, Oakland, California.
+ Rifas-Shiman, Sheryl L. Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
+ Mariani, Sara. Division of Sleep and Circadian Disorders, Department of Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, Massachusetts.
+ Kaplan, Emily R. Division of Sleep and Circadian Disorders, Department of Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, Massachusetts.
+ Rueschman, Michael. Division of Sleep and Circadian Disorders, Department of Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, Massachusetts.
+ Oken, Emily. Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
+ Taveras, Elsie M. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of General Academic Pediatrics, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts.
+ Redline, Susan. Division of Sleep and Circadian Disorders, Department of Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, Massachusetts; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ *Actigraphy/sn [Statistics & Numerical Data]
+ *Adiposity/ph [Physiology]
+ Adolescent
+ *Biomarkers
+ Blood Pressure
+ Body Mass Index
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Cohort Studies
+ Cross-Sectional Studies
+ Female
+ Humans
+ Lipids/bl [Blood]
+ Male
+ *Obesity/co [Complications]
+ Risk Factors
+ *Sleep/ph [Physiology]
+ Waist Circumference/ph [Physiology]
+Keyword Heading
+ Actigraphy
+ Adolescents
+ Obesity
+ Rest-activity patterns
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Emerging data indicate that the timing and rhythms of energetic behaviors may influence metabolism and obesity risk. Our aim was to derive diurnal rest-activity patterns from actigraphy in adolescents and analyze associations with adiposity measures and cardiometabolic risk factors.
+
+ METHODS: Adolescents in the Project Viva cohort wore a wrist actigraph over 7 days. We derived markers of daily rest-activity patterns from actigraphy using nonparametric models, generating measurements of relative amplitude (RA). RA reflects the normalized difference in activity measured during the most active 10-hour period and the least active 5-hour period, averaged over multiple 24-hour periods. Using multivariable-adjusted linear regression models, we estimated associations of RA and its components with markers of adiposity (body mass index, waist circumference, skinfolds, dual-energy X-ray absorptiometry fat mass) and cardiometabolic health (cardiometabolic risk score, derived as the mean of five sex-specific internal z-scores for waist circumference, systolic blood pressure, high-density lipoprotein cholesterol scaled inversely, and log-transformed triglycerides and homeostatic model assessment of insulin resistance).
+
+ RESULTS: A total of 778 adolescents provided at least 5 days of valid actigraphy data. The average age was 13.2 (+/-.9) years, 52% were female, and the average RA was .9 (+/-.1). A higher RA reflecting higher activity during wakefulness and lower activity during the night was associated with more favorable indices of adiposity (e.g., -.35 kg/m2 lower body mass index per each .04 units increment of RA; 95% confidence interval: -.60 to -.09).
+
+ CONCLUSIONS: In this large sample of adolescents, a higher RA emerged as a novel biomarker, associated with more favorable cardiometabolic profiles. Copyright © 2019 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.jadohealth.2019.02.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Quante&issn=1054-139X&title=Journal+of+Adolescent+Health&atitle=Association+of+Daily+Rest-Activity+Patterns+With+Adiposity+and+Cardiometabolic+Risk+Measures+in+Teens.&volume=65&issue=2&spage=224&epage=231&date=2019&doi=10.1016%2Fj.jadohealth.2019.02.008&pmid=31056236&sid=OVID:medline
+
+<1682>
+Unique Identifier
+ 31054116
+Title
+ The influence of Visfatin, RBP-4 and insulin resistance on bone mineral density in women with treated primary osteoporosis.
+Source
+ Aging-Clinical & Experimental Research. 31(6):889-895, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mihai G; Gasparik AI; Pascanu IM; Cevei M; Hutanu A; Pop RM
+Author NameID
+ Mihai, Gabriela; ORCID: http://orcid.org/0000-0003-1818-0508
+ Gasparik, Andrea Ildiko; ORCID: http://orcid.org/0000-0002-1848-2410
+ Pop, Raluca-Monica; ORCID: http://orcid.org/0000-0003-1775-4469
+Authors Full Name
+ Mihai, Gabriela; Gasparik, Andrea Ildiko; Pascanu, Ionela Maria; Cevei, Mariana; Hutanu, Adina; Pop, Raluca-Monica.
+Institution
+ Mihai, Gabriela. Department of Endocrinology, University of Medicine, Pharmacy, Sciences and Technology of Tirgu Mures, Str. Gh Marinescu nr 38, Tirgu Mures, Romania.
+ Gasparik, Andrea Ildiko. Department of Public Health and Health Management, University of Medicine, Pharmacy, Sciences and Technology of Tirgu Mures, Str. Gh Marinescu nr 38, Tirgu Mures, Romania. ildikogasparik@gmail.com.
+ Pascanu, Ionela Maria. Department of Endocrinology, University of Medicine, Pharmacy, Sciences and Technology of Tirgu Mures, Str. Gh Marinescu nr 38, Tirgu Mures, Romania.
+ Cevei, Mariana. Medical Rehabilitation Hospital Baile Felix, Comuna Sinmartin, Romania.
+ Hutanu, Adina. Department of Laboratory Medicine, Centre for Advanced Medical and Pharmaceutical Research, University of Medicine, Pharmacy, Sciences and Technology of Tirgu Mures, Str. Gh Marinescu nr 38, Tirgu Mures, Romania.
+ Pop, Raluca-Monica. Research Methodology Department, University of Medicine, Pharmacy, Sciences and Technology of Tirgu Mures, Str. Gh Marinescu nr 38, Tirgu Mures, Romania.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Bone Density/ph [Physiology]
+ *Cytokines/bl [Blood]
+ Female
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ Longitudinal Studies
+ Middle Aged
+ *Nicotinamide Phosphoribosyltransferase/bl [Blood]
+ Obesity/bl [Blood]
+ *Osteoporosis, Postmenopausal/bl [Blood]
+ *Retinol-Binding Proteins, Plasma/an [Analysis]
+Keyword Heading
+ Adipokines
+ Bone mineral density
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: The impact of the two adipokines, visfatin and retinol-binding protein 4 (RBP-4) on bone mineral density (BMD) has been analysed in various studies with conflicting results. Visfatin is highly expressed in visceral fat with stimulatory effect on osteoblast proliferation and inhibition on osteoclast formation, while RBP-4 acts as a transporter protein for retinol, associated with changes in insulin sensitivity, independent of obesity, with no consensus on its effect on bone metabolism. We evaluated the relationship between serum concentrations of visfatin, RBP-4, markers of insulin resistance and current BMD in treated postmenopausal osteoporosis (PO).
+
+ METHODS: Demographics, previous treatment, metabolic status, anthropometry, serum Alkaline phosphatise (ALP), visfatin, RBP-4, the HOMA IR (homeostatic model assessment of insulin resistance) index and BMD were evaluated in 61 subjects with PO. Statistical analysis used SPSS v. 25.0, with a level of significance alpha = 0.05. Regression models were constructed to evaluate the relationship between adipokines and BMD, adjusting for covariates.
+
+ RESULTS: In multilinear regression analysis, the strongest predictor for current BMD was a previous BMD, followed by ALP and age. RBP4 and HOMA IR were significant predictors, while visfatin had no significant effect. A significant correlation between body mass index (BMI) and BMD at the femoral neck was observed. ALP was negatively correlated with BMD and visfatin positively with RBP4.
+
+ CONCLUSIONS: Data indicate a positive relationship between BMD and RBP-4, an inverse relationship between markers of insulin resistance, bone turn-over and current BMD. No significant effect of visfatin on BMD was observed.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (RBP4 protein, human). 0 (Retinol-Binding Proteins, Plasma). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase). EC 2-4-2-12 (nicotinamide phosphoribosyltransferase, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs40520-019-01206-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mihai&issn=1594-0667&title=Aging-Clinical+%26+Experimental+Research&atitle=The+influence+of+Visfatin%2C+RBP-4+and+insulin+resistance+on+bone+mineral+density+in+women+with+treated+primary+osteoporosis.&volume=31&issue=6&spage=889&epage=895&date=2019&doi=10.1007%2Fs40520-019-01206-6&pmid=31054116&sid=OVID:medline
+
+<1683>
+Unique Identifier
+ 31053416
+Title
+ Vascular Regenerative Cell Exhaustion in Diabetes: Translational Opportunities to Mitigate Cardiometabolic Risk. [Review]
+Source
+ Trends in Molecular Medicine. 25(7):640-655, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Terenzi DC; Trac JZ; Teoh H; Gerstein HC; Bhatt DL; Al-Omran M; Verma S; Hess DA
+Authors Full Name
+ Terenzi, Daniella C; Trac, Justin Z; Teoh, Hwee; Gerstein, Hertzel C; Bhatt, Deepak L; Al-Omran, Mohammed; Verma, Subodh; Hess, David A.
+Institution
+ Terenzi, Daniella C. Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, M5 B 1W8, Canada; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A1, Canada.
+ Trac, Justin Z. Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, M5 B 1W8, Canada; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
+ Teoh, Hwee. Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, M5 B 1W8, Canada; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital Medical Centre, Toronto, ON, M5C 2T2, Canada.
+ Gerstein, Hertzel C. Division of Endocrinology and Metabolism, McMaster University and Hamilton Health Sciences, Population Health Research Institute, Hamilton, ON, L8S 4K1, Canada.
+ Bhatt, Deepak L. Brigham and Women's Hospital, Heart and Vascular Center, Harvard Medical School, Boston, MA 02115, USA.
+ Al-Omran, Mohammed. Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A1, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada; Division of Vascular Surgery, St. Michael's Hospital, Toronto, ON, M5 B 1W8, Canada; Department of Surgery, University of Toronto, Toronto, ON, M5T 1P5, Canada; Department of Surgery, King Saud University, Riyadh, 11451, Saudi Arabia.
+ Verma, Subodh. Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, M5 B 1W8, Canada; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, M5 B 1T8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A1, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada; Department of Surgery, University of Toronto, Toronto, ON, M5T 1P5, Canada.
+ Hess, David A. Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada; Division of Vascular Surgery, St. Michael's Hospital, Toronto, ON, M5 B 1W8, Canada; Department of Physiology and Pharmacology, Western University, London, ON, N6A 5C1, Canada; Robarts Research Institute, Western University, London, ON, N6A 5B7, Canada. Electronic address: dhess@robarts.ca.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Blood Vessels/me [Metabolism]
+ Blood Vessels/pa [Pathology]
+ Bone Marrow
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/me [Metabolism]
+ Cardiovascular Physiological Phenomena
+ Cell Differentiation
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/th [Therapy]
+ *Disease Susceptibility
+ Extracellular Vesicles/me [Metabolism]
+ Humans
+ *Neovascularization, Physiologic
+ Obesity/me [Metabolism]
+ Obesity/su [Surgery]
+ Oxidative Stress
+ Risk
+ Signal Transduction
+ Stem Cell Niche
+ Translational Research, Biomedical
+Keyword Heading
+ bariatric surgery
+ bone marrow
+ diabetes
+ exosomes
+ inflammation
+ ischemia
+ oxidative stress
+ progenitor cells
+ revascularization
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Ischemic cardiovascular complications remain a major cause of mortality in people with type 2 diabetes (T2D). Individuals with T2D may have a reduced ability to revascularize ischemic tissues due to abnormal production of circulating provascular progenitor cells. This 'regenerative cell exhaustion' process is intensified by increasing oxidative stress and inflammation and during T2D progression. Chronic exhaustion may be mediated by changes in the bone marrow microenvironment that dysregulate the wingless related integration site network, a central pathway maintaining the progenitor cell pool. Restoration of vascular regenerative cell production by reducing glucotoxicity with contemporary antihyperglycemic agents, by reducing systemic inflammation postbariatric surgery, or by modulating progenitor cell provascular functions using exosomal manipulation, may provide unique approaches for mitigating ischemic disease. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.molmed.2019.03.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Terenzi&issn=1471-4914&title=Trends+in+Molecular+Medicine&atitle=Vascular+Regenerative+Cell+Exhaustion+in+Diabetes%3A+Translational+Opportunities+to+Mitigate+Cardiometabolic+Risk.&volume=25&issue=7&spage=640&epage=655&date=2019&doi=10.1016%2Fj.molmed.2019.03.006&pmid=31053416&sid=OVID:medline
+
+<1684>
+Unique Identifier
+ 31049150
+Title
+ High-Density Lipoprotein Subspecies in Health and Human Disease: Focus on Type 2 Diabetes. [Review]
+Source
+ Methodist DeBakey cardiovascular journal. 15(1):55-61, 2019 Jan-Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Davidson WS; Shah AS
+Authors Full Name
+ Davidson, W Sean; Shah, Amy S.
+Institution
+ Davidson, W Sean. UNIVERSITY OF CINCINNATI, CINCINNATI, OHIO.
+ Shah, Amy S. UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE, CINCINNATI, OHIO.
+ Shah, Amy S. CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER, CINCINNATI, OHIO.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ *Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/dt [Drug Therapy]
+ Dyslipidemias/ep [Epidemiology]
+ Humans
+ Hypolipidemic Agents/tu [Therapeutic Use]
+ Insulin/bl [Blood]
+ Insulin Resistance
+ *Lipoproteins, HDL/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+Keyword Heading
+ high-density lipoprotein
+ lipids
+ lipoprotein
+ lipoprotein subspecies
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Plasma cholesterol levels of high-density lipoproteins (HDL) have been associated with cardioprotection for decades. However, there is an evolving appreciation that this lipoprotein class is highly heterogeneous with regard to composition and functionality. With the advent of advanced lipid-testing techniques and methods that allow both the quantitation and recovery of individual particle populations, we are beginning to connect the functionality of HDL subspecies with chronic metabolic diseases. In this review, we examine type 2 diabetes (T2D) and explore our current understanding of how obesity, insulin resistance, and hyperglycemia affect, and may be affected by, HDL subspeciation. We discuss mechanistic aspects of how insulin resistance may alter lipoprotein profiles and how this may impact the ability of HDL to mitigate both atherosclerotic disease and diabetes itself. Finally, we call for more detailed studies examining the impact of T2D on specific HDL subspecies and their functions. If these particles can be isolated and their compositions and functions fully elucidated, it may become possible to manipulate the levels of these specific particles or target the protective functions to reduce the incidence of coronary heart disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hypolipidemic Agents). 0 (Insulin). 0 (Lipoproteins, HDL).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.14797%2fmdcj-15-1-55
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Davidson&issn=1947-6108&title=Methodist+DeBakey+cardiovascular+journal&atitle=High-Density+Lipoprotein+Subspecies+in+Health+and+Human+Disease%3A+Focus+on+Type+2+Diabetes.&volume=15&issue=1&spage=55&epage=61&date=2019&doi=10.14797%2Fmdcj-15-1-55&pmid=31049150&sid=OVID:medline
+
+<1685>
+Unique Identifier
+ 31048785
+Title
+ Amelioration of obesity-related biomarkers by Lactobacillus sakei CJLS03 in a high-fat diet-induced obese murine model.
+Source
+ Scientific Reports. 9(1):6821, 2019 05 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ji Y; Park S; Chung Y; Kim B; Park H; Huang E; Jeong D; Jung HY; Kim B; Hyun CK; Holzapfel WH
+Author NameID
+ Ji, Yosep; ORCID: http://orcid.org/0000-0001-5349-7901
+ Kim, Bobae; ORCID: http://orcid.org/0000-0003-1624-8337
+ Huang, Eunchong; ORCID: http://orcid.org/0000-0003-3760-6164
+ Hyun, Chang-Kee; ORCID: http://orcid.org/0000-0003-1862-8739
+ Holzapfel, Wilhelm H; ORCID: http://orcid.org/0000-0002-3669-1419
+Authors Full Name
+ Ji, Yosep; Park, Soyoung; Chung, Youngmee; Kim, Bobae; Park, Haryung; Huang, Eunchong; Jeong, Dahye; Jung, Hoe-Yune; Kim, Bongjoon; Hyun, Chang-Kee; Holzapfel, Wilhelm H.
+Institution
+ Ji, Yosep. Advanced Green Energy and Environment, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea.
+ Park, Soyoung. Advanced Green Energy and Environment, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea.
+ Chung, Youngmee. CJ Blossom Park, 42, Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16495, Republic of Korea.
+ Kim, Bobae. Advanced Green Energy and Environment, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea.
+ Kim, Bobae. School of Life Science, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea.
+ Park, Haryung. Advanced Green Energy and Environment, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea.
+ Huang, Eunchong. Advanced Green Energy and Environment, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea.
+ Jeong, Dahye. CJ Blossom Park, 42, Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16495, Republic of Korea.
+ Jung, Hoe-Yune. Department of Life Science, Division of Integrative Biosciences and Biotechnology, POSTECH, Pohang, Gyungbuk, 37673, Republic of Korea.
+ Kim, Bongjoon. CJ Blossom Park, 42, Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16495, Republic of Korea.
+ Hyun, Chang-Kee. Advanced Green Energy and Environment, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea.
+ Hyun, Chang-Kee. School of Life Science, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea.
+ Holzapfel, Wilhelm H. Advanced Green Energy and Environment, Handong Global University, Pohang, Gyungbuk, 37554, Republic of Korea. wilhelm@woodapple.net.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ *Biomarkers
+ *Diet, High-Fat
+ Disease Models, Animal
+ Fatty Acids, Volatile/me [Metabolism]
+ *Gastrointestinal Microbiome
+ *Latilactobacillus sakei
+ Mice
+ Mice, Obese
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Weight Gain
+Abstract
+ Recent progresses in clinical diagnostic analyses have demonstrated the decisive influence of host gut microbiota on the status of metabolic disorders. Short chain fatty acids (SCFAs) produced by gut microbiota, in particular, are considered as a key biomarker, both of communication between gut microbiota and the host, and of impact on host metabolic homeostasis. Microbiota modulation and concomitant anti-obesity effects of probiotics have been reported by different researchers. However, the underlying modulatory functions of probiotics on gut microbiota towards host metabolic homeostasis are still not fully understood. In this study, the impact of Lactobacillus sakei CJLS03 (isolated from Korean kimchi) on obesity-related biomarkers was investigated using a diet-induced obese mouse model. Body weight increase, SCFAs, the gut microbiota and various obesity-associated biomarkers were significantly and beneficially influenced by L. sakei CJLS03 administration compared to the control groups. Analytical data on faecal samples support the role of the colonic microbial population in SCFA production. The composition of the latter may be influenced by modulation of the distal gastro-intestinal microbiota by putative probiotics such as L. sakei CJLS03.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Volatile).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-43092-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ji&issn=2045-2322&title=Scientific+Reports&atitle=Amelioration+of+obesity-related+biomarkers+by+Lactobacillus+sakei+CJLS03+in+a+high-fat+diet-induced+obese+murine+model.&volume=9&issue=1&spage=6821&epage=&date=2019&doi=10.1038%2Fs41598-019-43092-y&pmid=31048785&sid=OVID:medline
+
+<1686>
+Unique Identifier
+ 31047948
+Title
+ Additive stress of normobaric hypoxic conditioning to improve body mass loss and cardiometabolic markers in individuals with overweight or obesity: A systematic review and meta-analysis. [Review]
+Source
+ Physiology & Behavior. 207:28-40, 2019 08 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ramos-Campo DJ; Girard O; Perez A; Rubio-Arias JA
+Authors Full Name
+ Ramos-Campo, Domingo J; Girard, Olivier; Perez, Andres; Rubio-Arias, Jacobo A.
+Institution
+ Ramos-Campo, Domingo J. Department of Physical Activity and Sports Sciences, Faculty of Sports, UCAM, Catholic University San Antonio, Murcia, Spain. Electronic address: djramos@ucam.edu.
+ Girard, Olivier. Murdoch Applied Sport Science Laboratory, Murdoch University, Perth, Australia.
+ Perez, Andres. UCAM Research Centre for High Performance Sport, Catholic University San Antonio, Murcia, Spain.
+ Rubio-Arias, Jacobo A. Department of Physical Activity and Sports Sciences, Faculty of Sports, UCAM, Catholic University San Antonio, Murcia, Spain.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Health Status
+ Humans
+ *Hypoxia/me [Metabolism]
+ *Myocardium/me [Metabolism]
+ *Obesity/me [Metabolism]
+ *Obesity/th [Therapy]
+ *Overweight/me [Metabolism]
+ *Overweight/th [Therapy]
+ *Physical Conditioning, Human/ph [Physiology]
+ *Stress, Physiological/ph [Physiology]
+ Weight Loss
+Keyword Heading
+ Body mass
+ Cardio-metabolic health
+ Hypoxia
+ Hypoxic training
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We performed a systematic review and meta-analysis to determine if hypoxic conditioning, compared to similar training near sea level, maximizes body mass loss and further improves cardiometabolic markers in overweight and obese individuals. A systematic search of PubMed, Web of Science and the Cochrane Library databases (up to January 2019) was performed. This analysis included randomized controlled trials with humans with overweight or obesity assessing the effects of HC on body mass loss or cardiometabolic markers. A subgroup analysis was performed to examine if HC effects differed between individuals with overweight or obesity. 13 articles (336 participants) qualified for inclusion. HC significantly decreased body mass (p=.01), fat mass (p=.04), waist/hip ratio (p<.001), waist (p<.001), LDL (p=.01), diastolic (p<.01) and systolic blood pressure (p<.01) with these effects not being larger than equivalent normoxic interventions. There were trends towards higher triglycerides decrement (p=.06) and higher muscle mass gain in hypoxic (p=.08) compared with normoxic condition. Also, the two BMI categories displayed no difference in the magnitude of the responses. Compared to normoxic equivalent, HC provides greater reductions in triglycerides and greater muscle growth, while body mass changes are similar. In addition, HC responses were essentially similar between individuals with overweight or obesity. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Review. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.physbeh.2019.04.027
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ramos-Campo&issn=0031-9384&title=Physiology+%26+Behavior&atitle=Additive+stress+of+normobaric+hypoxic+conditioning+to+improve+body+mass+loss+and+cardiometabolic+markers+in+individuals+with+overweight+or+obesity%3A+A+systematic+review+and+meta-analysis.&volume=207&issue=&spage=28&epage=40&date=2019&doi=10.1016%2Fj.physbeh.2019.04.027&pmid=31047948&sid=OVID:medline
+
+<1687>
+Unique Identifier
+ 31043667
+Title
+ A novel data fusion method for the effective analysis of multiple panels of flow cytometry data.
+Source
+ Scientific Reports. 9(1):6777, 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tinnevelt GH; van Staveren S; Wouters K; Wijnands E; Verboven K; Folcarelli R; Koenderman L; Buydens LMC; Jansen JJ
+Author NameID
+ Tinnevelt, Gerjen H; ORCID: http://orcid.org/0000-0003-0758-4128
+ Koenderman, Leo; ORCID: http://orcid.org/0000-0002-5636-6453
+Authors Full Name
+ Tinnevelt, Gerjen H; van Staveren, Selma; Wouters, Kristiaan; Wijnands, Erwin; Verboven, Kenneth; Folcarelli, Rita; Koenderman, Leo; Buydens, Lutgarde M C; Jansen, Jeroen J.
+Institution
+ Tinnevelt, Gerjen H. Radboud University, Institute for Molecules and Materials (Analytical Chemistry), postvak 61, P.O. Box 9010, 6500 GL, Nijmegen, The Netherlands. chemometrics@science.ru.nl.
+ Tinnevelt, Gerjen H. TI-COAST, Science Park 904, 1098 XH, Amsterdam, The Netherlands. chemometrics@science.ru.nl.
+ van Staveren, Selma. TI-COAST, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
+ van Staveren, Selma. Department of Respiratory Medicine and laboratory of translational immunology (LTI), University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.
+ Wouters, Kristiaan. Deptartment of Internal Medicine Laboratory of Metabolism and Vascular Medicine, P.O. Box 616 (UNS50/14), 6200 MD, Maastricht, The Netherlands.
+ Wijnands, Erwin. Experimental Vascular Pathology group, P.O. Box 5800, 6202 MZ, Maastricht, The Netherlands.
+ Verboven, Kenneth. REVAL - Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.
+ Verboven, Kenneth. BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
+ Folcarelli, Rita. Radboud University, Institute for Molecules and Materials (Analytical Chemistry), postvak 61, P.O. Box 9010, 6500 GL, Nijmegen, The Netherlands.
+ Koenderman, Leo. Department of Respiratory Medicine and laboratory of translational immunology (LTI), University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.
+ Buydens, Lutgarde M C. Radboud University, Institute for Molecules and Materials (Analytical Chemistry), postvak 61, P.O. Box 9010, 6500 GL, Nijmegen, The Netherlands.
+ Jansen, Jeroen J. Radboud University, Institute for Molecules and Materials (Analytical Chemistry), postvak 61, P.O. Box 9010, 6500 GL, Nijmegen, The Netherlands.
+MeSH Subject Headings
+ Antibodies, Monoclonal/im [Immunology]
+ *Biomarkers/an [Analysis]
+ Discriminant Analysis
+ *Flow Cytometry/mt [Methods]
+ Humans
+ *Immunophenotyping/mt [Methods]
+ *Obesity/pp [Physiopathology]
+ Phenotype
+ *Thinness/pp [Physiopathology]
+Abstract
+ Multicolour flow cytometry (MFC) is used to measure multiple cellular markers at the single-cell level. Cellular markers may be coloured with different panels of fluorescently-labelled antibodies to enable cell identification or the detection of activated cells in pre-defined, 'gated' specific cell subsets. The number of markers that can be used per measurement is technologically limited however, requiring every panel to be analysed in a separate aliquot measurement. The combined analyses of these dedicated panels may enhance the predictive ability of these measurements and could enrich the interpretation of the immunological information. Here we introduce a fusion method for MFC data, based on DAMACY (Discriminant Analysis of Multi-Aspect Cytometry data), which can combine information from complementary panels. This approach leads to both enhanced predictions and clearer interpretations in comparison with the analysis of separate measurements. We illustrate this method using two datasets: the response of neutrophils evoked by a systemic endotoxin challenge and the activated immune status of the innate cells, T cells and B cells in obese versus lean individuals. The data fusion approach was able to detect cells that do not individually show a difference between clinical phenotypes but do play a role in combination with other cells.
+Registry Number/Name of Substance
+ 0 (Antibodies, Monoclonal). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-43166-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tinnevelt&issn=2045-2322&title=Scientific+Reports&atitle=A+novel+data+fusion+method+for+the+effective+analysis+of+multiple+panels+of+flow+cytometry+data.&volume=9&issue=1&spage=6777&epage=&date=2019&doi=10.1038%2Fs41598-019-43166-x&pmid=31043667&sid=OVID:medline
+
+<1688>
+Unique Identifier
+ 31042670
+Title
+ Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: a randomised controlled trial in healthy obese women.
+Source
+ European Journal of Endocrinology. 180(6):417-427, 2019 Jun 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Otten J; Ryberg M; Mellberg C; Andersson T; Chorell E; Lindahl B; Larsson C; Holst JJ; Olsson T
+Authors Full Name
+ Otten, Julia; Ryberg, Mats; Mellberg, Caroline; Andersson, Tomas; Chorell, Elin; Lindahl, Bernt; Larsson, Christel; Holst, Jens Juul; Olsson, Tommy.
+Institution
+ Otten, Julia. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Ryberg, Mats. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Mellberg, Caroline. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Andersson, Tomas. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Chorell, Elin. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Lindahl, Bernt. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+ Larsson, Christel. Department of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden.
+ Holst, Jens Juul. NNF Center for Basal Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Olsson, Tommy. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Diet, Paleolithic
+ Energy Intake/ph [Physiology]
+ Female
+ *Gastric Inhibitory Polypeptide/bl [Blood]
+ *Glucagon/bl [Blood]
+ *Glucagon-Like Peptide 1/bl [Blood]
+ Humans
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ Postprandial Period/ph [Physiology]
+ *Weight Loss/ph [Physiology]
+Abstract
+ Objective To investigate how weight loss by different diets impacts postprandial levels of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon. Methods In this single-centre, parallel group 2-year trial, 70 healthy postmenopausal obese women were randomised to the Paleolithic diet or a healthy control diet based on Nordic Nutrition Recommendations. Both diets were without calorie restriction. The primary outcome was the change in fat mass. Here, secondary analyses on GLP-1, GIP and glucagon measured during an OGTT are described. Results In the Paleolithic diet group, mean weight loss compared to baseline was 11% at 6 months and 10% at 24 months. In the control diet group, mean weight loss was 6% after 6 and 24 months (P = 0.0001 and P = 0.049 for the comparison between groups at 6 and 24 months respectively). Compared to baseline, the mean incremental area under the curve (iAUC) for GLP-1 increased by 34 and 45% after 6 and 24 months in the Paleolithic diet group and increased by 59% after 24 months in the control diet group. The mean iAUC for GIP increased only in the Paleolithic diet group. The area under the curve (AUC) for glucagon increased during the first 6 months in both groups. The fasting glucagon increase correlated with the beta-hydroxybutyrate increase. Conclusions Weight loss caused an increase in postprandial GLP-1 levels and a further rise occurred during weight maintenance. Postprandial GIP levels increased only after the Paleolithic diet. Reduced postprandial glucagon suppression may be caused by a catabolic state.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 59392-49-3 (Gastric Inhibitory Polypeptide). 89750-14-1 (Glucagon-Like Peptide 1). 9007-92-5 (Glucagon).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1530%2fEJE-19-0082
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Otten&issn=0804-4643&title=European+Journal+of+Endocrinology&atitle=Postprandial+levels+of+GLP-1%2C+GIP+and+glucagon+after+2+years+of+weight+loss+with+a+Paleolithic+diet%3A+a+randomised+controlled+trial+in+healthy+obese+women.&volume=180&issue=6&spage=417&epage=427&date=2019&doi=10.1530%2FEJE-19-0082&pmid=31042670&sid=OVID:medline
+
+<1689>
+Unique Identifier
+ 31041685
+Title
+ Circulating adipose stromal cells as a response biomarker in phase II energy balance trials of obese breast cancer survivors and high-risk women.
+Source
+ Breast Cancer Research & Treatment. 176(2):387-394, 2019 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baker HA; Fabian CJ; Hastings RC; Dixon DA; Nydegger JL; Phillips TA; Powers KR; Kimler BF
+Authors Full Name
+ Baker, Hailey A; Fabian, Carol J; Hastings, Richard C; Dixon, Dan A; Nydegger, Jennifer L; Phillips, Teresa A; Powers, Kandy R; Kimler, Bruce F.
+Institution
+ Baker, Hailey A. University of Kansas School of Medicine-Wichita, 1010 N Kansas St., Wichita, KS, 67214, USA.
+ Fabian, Carol J. Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA. cfabian@kumc.edu.
+ Hastings, Richard C. Flow Cytometry Core Laboratory, Department of Microbiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.
+ Dixon, Dan A. Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave., Lawrence, KS, 66045, USA.
+ Nydegger, Jennifer L. Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.
+ Phillips, Teresa A. Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.
+ Powers, Kandy R. Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.
+ Kimler, Bruce F. Department of Radiation Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.
+MeSH Subject Headings
+ Adipose Tissue/cy [Cytology]
+ *Adipose Tissue/im [Immunology]
+ Aged
+ Antigens, CD34/me [Metabolism]
+ *Biomarkers/bl [Blood]
+ *Breast Neoplasms/bl [Blood]
+ Breast Neoplasms/im [Immunology]
+ Cancer Survivors
+ Cross-Sectional Studies
+ Diet Therapy
+ Exercise Therapy
+ Female
+ Humans
+ Leukocyte Common Antigens/me [Metabolism]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/im [Immunology]
+ *Obesity/th [Therapy]
+ Platelet Endothelial Cell Adhesion Molecule-1/me [Metabolism]
+ Postmenopause
+ Premenopause
+ Stromal Cells/cy [Cytology]
+ Stromal Cells/im [Immunology]
+Keyword Heading
+ Breast cancer
+ Obesity
+ Risk biomarkers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Circulating adipose stromal cells (CASC) are thought to be increased in obesity and facilitate angiogenesis, and tumor metastases.
+
+ METHODS: CASC were identified from buffy coat peripheral blood mononuclear cells (PBMCs) by flow cytometry as CD34brightCD31- CD45- and CASC frequency was compared to adiposity measures in 33 women at increased risk for breast cancer. Feasibility of CASC as a response biomarker for a diet and exercise intervention in ten breast cancer survivors was then explored.
+
+ RESULTS: For 33 high-risk women, median CASC frequency was 9.7 per million PBMCs and trended positively with body mass index, fat mass index (FMI), and percent android fat. Correlation was significant when BMI was dichotomized at > versus < 35 kg/m2 (p = 0.02). For ten breast cancer survivors with a median BMI of 37 kg/m2, median CASC frequency was 16.4 per million PBMCs. In univariate analyses, change in BMI, total fat and visceral fat were significantly correlated with change in CASC frequency. On multivariate analysis, change in visceral adipose had the strongest association with change in CASC frequency (p < 0.00078).
+
+ CONCLUSIONS: The association between the reduction in visceral adipose tissue and the decrease in frequency of circulating adipose stromal cells suggests that the latter might be a useful biomarker in clinical trials of obese breast cancer survivors undergoing a weight loss intervention.
+Registry Number/Name of Substance
+ 0 (Antigens, CD34). 0 (Biomarkers). 0 (PECAM1 protein, human). 0 (Platelet Endothelial Cell Adhesion Molecule-1). EC 3-1-3-48 (Leukocyte Common Antigens). EC 3-1-3-48 (PTPRC protein, human).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs10549-019-05251-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baker&issn=0167-6806&title=Breast+Cancer+Research+%26+Treatment&atitle=Circulating+adipose+stromal+cells+as+a+response+biomarker+in+phase+II+energy+balance+trials+of+obese+breast+cancer+survivors+and+high-risk+women.&volume=176&issue=2&spage=387&epage=394&date=2019&doi=10.1007%2Fs10549-019-05251-7&pmid=31041685&sid=OVID:medline
+
+<1690>
+Unique Identifier
+ 31040059
+Title
+ Left Gastric Artery Embolization in Obese, Prediabetic Patients: A Pilot Study.
+Source
+ Journal of Vascular & Interventional Radiology. 30(6):790-796, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zaitoun MMA; Basha MAA; Hassan F; Elsayed SB; Farag AA; Amer M; Aly SA; Zaitoun N
+Authors Full Name
+ Zaitoun, Mohamed M A; Basha, Mohammad Abd Alkhalik; Hassan, Farouk; Elsayed, Saeed Bakry; Farag, Alaa A; Amer, Mahmoud; Aly, Sameh Abdelaziz; Zaitoun, Nahla.
+Institution
+ Zaitoun, Mohamed M A. Department of Radiodiagnosis, Zagazig University, Zagazig 644631, Egypt.
+ Basha, Mohammad Abd Alkhalik. Department of Radiodiagnosis, Zagazig University, Zagazig 644631, Egypt. Electronic address: Mohammad_basha76@yahoo.com.
+ Hassan, Farouk. Department of Radiodiagnosis, Cairo University, Cairo, Egypt.
+ Elsayed, Saeed Bakry. Department of Radiodiagnosis, Zagazig University, Zagazig 644631, Egypt.
+ Farag, Alaa A. Department of Internal Medicine, Zagazig University, Zagazig 644631, Egypt.
+ Amer, Mahmoud. Department of Internal Medicine, Zagazig University, Zagazig 644631, Egypt.
+ Aly, Sameh Abdelaziz. Department of Radiodiagnosis, Benha University, Benha, Egypt.
+ Zaitoun, Nahla. Department of Community and Family Medicine, Zagazig University, Zagazig 644631, Egypt.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Embolization, Therapeutic/ae [Adverse Effects]
+ *Embolization, Therapeutic/mt [Methods]
+ Female
+ Gastric Artery/dg [Diagnostic Imaging]
+ *Gastric Artery
+ *Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Pilot Projects
+ Prediabetic State/bl [Blood]
+ Prediabetic State/di [Diagnosis]
+ Prediabetic State/pp [Physiopathology]
+ *Prediabetic State/th [Therapy]
+ Prospective Studies
+ Radiography, Interventional
+ Time Factors
+ Treatment Outcome
+ *Weight Loss
+Abstract
+ PURPOSE: To evaluate the effect of left gastric artery embolization (LGAE) on glycated hemoglobin (HbA1c) in a prospective obese, prediabetic cohort.
+
+ MATERIALS AND METHODS: This prospective pilot study included 10 obese, prediabetic patients (7 females and 3 males; mean age 37.5 +/- 8.8 years; range 28-51 years) admitted to the Interventional Radiology Unit between January 2017 and June 2018 for LGAE for weight reduction. The main inclusion criteria were body mass index (BMI) >30 kg/m2 and HbA1c ranging from 5.7 to 6.4. Body weight, BMI, and HbA1c were assessed for each patient preprocedure and at 6 months postprocedure. Statistical analysis was performed using a paired sample t test.
+
+ RESULTS: The baseline mean body weight, BMI, and HbA1c were 107.4 +/- 12.8 kg, 37.4 +/- 3.3 kg/m2, and 6 +/- 0.2, respectively. Concerning complications, no serious adverse events were detected. Six months after the procedure, the mean body weight and BMI significantly decreased to 98 +/- 11.6 kg and 34.1 +/- 3 kg/m2, respectively (P < .0001). A paired sample t test showed a significant reduction in HbA1c from pre- to postprocedure (6.1 +/- 0.2 preprocedure vs 4.7 +/- 0.6 postprocedure, P < .0001). The mean percent reductions in body weight, BMI, and HbA1c were 8.9% +/- 1.2, 8.8% +/- 1, and 21.4% +/- 8.9, respectively. A statistically significant positive correlation was found between BMI and HbA1c after the procedure (r = 0.91, P = .0002).
+
+ CONCLUSIONS: LGAE is well tolerated and leads to clinically significant decreases in weight and HbA1c in obese, prediabetic patients. Copyright © 2019 SIR. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.jvir.2019.02.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zaitoun&issn=1051-0443&title=Journal+of+Vascular+%26+Interventional+Radiology&atitle=Left+Gastric+Artery+Embolization+in+Obese%2C+Prediabetic+Patients%3A+A+Pilot+Study.&volume=30&issue=6&spage=790&epage=796&date=2019&doi=10.1016%2Fj.jvir.2019.02.010&pmid=31040059&sid=OVID:medline
+
+<1691>
+Unique Identifier
+ 31037612
+Title
+ Issues in Measuring and Interpreting Human Appetite (Satiety/Satiation) and Its Contribution to Obesity. [Review]
+Source
+ Current Obesity Reports. 8(2):77-87, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gibbons C; Hopkins M; Beaulieu K; Oustric P; Blundell JE
+Authors Full Name
+ Gibbons, Catherine; Hopkins, Mark; Beaulieu, Kristine; Oustric, Pauline; Blundell, John E.
+Institution
+ Gibbons, Catherine. School of Psychology, University of Leeds, 4 Lifton Place, Leeds, LS2 9JT, UK. c.gibbons@leeds.ac.uk.
+ Hopkins, Mark. School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK.
+ Beaulieu, Kristine. School of Psychology, University of Leeds, 4 Lifton Place, Leeds, LS2 9JT, UK.
+ Oustric, Pauline. School of Psychology, University of Leeds, 4 Lifton Place, Leeds, LS2 9JT, UK.
+ Blundell, John E. School of Psychology, University of Leeds, 4 Lifton Place, Leeds, LS2 9JT, UK.
+MeSH Subject Headings
+ *Appetite
+ Appetite Regulation
+ Biomarkers/bl [Blood]
+ Body Composition
+ Eating/px [Psychology]
+ Energy Metabolism
+ Gastrointestinal Hormones/bl [Blood]
+ Health Behavior
+ Humans
+ Hunger
+ Meals
+ *Obesity/ep [Epidemiology]
+ Obesity/px [Psychology]
+ Peptide Hormones/bl [Blood]
+ Portion Size
+ *Satiation
+Keyword Heading
+ Appetite control
+ Energy balance
+ Obesity
+ Satiation
+ Satiety
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE OF REVIEW: The goals of this paper are to report current research practices in investigations of human appetite control and to assess their relationships with emerging theoretical principles. Appetite is often distinguished by the separation of homeostatic and hedonic processes.
+
+ RECENT FINDINGS: This report assesses the validity of a homeostatic toolkit to measure subjectively perceived hunger and its relationship to the developing processes of satiation (control of meal size) and satiety (control of the post-eating period). The capacity of a procedure to measure the influence of hedonic processes on food intake is also evaluated. A major issue is the relationship between the pattern of eating behaviour (influenced by the underlying drive to eat and the inhibition induced by the act of eating itself) and the parallel underlying profile of hormonal and other metabolic biomarkers. Increasing recognition is being given to individual variability in the expression of appetite, and the fact that the use of the average (mean) response conceals important information about the nature of appetite control. There is a growing interest in the identification of satiety phenotypes that operate in parallel to metabolic phenotypes. Interestingly, energy expenditure (metabolic and behavioural) contributes to an energy balance framework for understanding energy intake (appetite).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Gastrointestinal Hormones). 0 (Peptide Hormones).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs13679-019-00340-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gibbons&issn=2162-4968&title=Current+Obesity+Reports&atitle=Issues+in+Measuring+and+Interpreting+Human+Appetite+%28Satiety%2FSatiation%29+and+Its+Contribution+to+Obesity.&volume=8&issue=2&spage=77&epage=87&date=2019&doi=10.1007%2Fs13679-019-00340-6&pmid=31037612&sid=OVID:medline
+
+<1692>
+Unique Identifier
+ 31032750
+Title
+ Dopaminergic Genes Polymorphisms and Prefrontal Cortex Efficiency Among Obese People - Whether Gender is a Differentiating Factor?.
+Source
+ Current Molecular Medicine. 19(6):405-418, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bielinski M; Lesiewska N; Junik R; Kaminska A; Tretyn A; Borkowska A
+Authors Full Name
+ Bielinski, Maciej; Lesiewska, Natalia; Junik, Roman; Kaminska, Anna; Tretyn, Andrzej; Borkowska, Alina.
+Institution
+ Bielinski, Maciej. Chair and Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Poland.
+ Lesiewska, Natalia. Chair and Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Poland.
+ Junik, Roman. Department of Endocrinology and Diabetology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Poland.
+ Kaminska, Anna. Department of Endocrinology and Diabetology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Poland.
+ Tretyn, Andrzej. Department of Biotechnology, Nicolaus Copernicus University in Torun, Poland.
+ Borkowska, Alina. Chair and Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Poland.
+MeSH Subject Headings
+ Adult
+ Aged
+ Alleles
+ Biomarkers
+ *Dopamine/me [Metabolism]
+ Female
+ Genotype
+ Humans
+ Male
+ Middle Aged
+ Neuropsychological Tests
+ *Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ Obesity/px [Psychology]
+ *Polymorphism, Genetic
+ *Prefrontal Cortex/me [Metabolism]
+ Sex Factors
+Keyword Heading
+ Dopaminergic signaling
+ Wisconsin Card Sorting Test
+ executive functions
+ gene polymorphism
+ obesity.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a chronic condition associated with poorer cognitive functioning. Wisconsin Card Sorting Test (WCST) is a useful tool for evaluating executive functions. In this study, we assessed the association between dopaminergic gene polymorphisms: DAT1 (SLC6A3), COMTVal158Met, DRD4 (48-bp variable number of tandem repeats - VNTR) and WCST parameters to investigate the functions of the frontal lobes in obese individuals.
+
+ OBJECTIVE: To find the significant correlations between polymorphisms of DAT1, COMTVal158Met, DRD4 and executive functions in obese subjects.
+
+ METHODS: The analysis of the frequency of individual alleles was performed in 248 obese patients (179 women, 69 men). Evaluation of the prefrontal cortex function (operating memory and executive functions) was measured with the Wisconsin Card Sorting Test (WCST). Separate analyzes were performed in age subgroups to determine different activities and regulation of genes in younger and older participants.
+
+ RESULTS: Scores of WCST parameters were different in the subgroups of women and men and in the age subgroups. Regarding the COMT gene, patients with A/A and G/A polymorphisms showed significantly better WCST results in WCST_P, WCST_CC and WCST_1st. Regarding DAT1 men with L/L and L/S made less non-perseverative errors, which was statistically significant. In DRD4, significantly better WCST_1st results were found only in older women with S allele.
+
+ CONCLUSION: Obtained results indicate the involvement of dopaminergic transmission in the regulation of prefrontal cortex function. Data analysis indicates that prefrontal cortex function may ensue, from different elements such as genetic factors, metabolic aspects of obesity, and hormonal activity (estrogen). Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers). VTD58H1Z2X (Dopamine).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2174%2f1566524019666190424143653
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bielinski&issn=1566-5240&title=Current+Molecular+Medicine&atitle=Dopaminergic+Genes+Polymorphisms+and+Prefrontal+Cortex+Efficiency+Among+Obese+People+-+Whether+Gender+is+a+Differentiating+Factor%3F.&volume=19&issue=6&spage=405&epage=418&date=2019&doi=10.2174%2F1566524019666190424143653&pmid=31032750&sid=OVID:medline
+
+<1693>
+Unique Identifier
+ 31028187
+Title
+ Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice.
+Source
+ In Vivo. 33(3):707-715, 2019 May-Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jung YC; Kim HW; Min BK; Cho JY; Son HJ; Lee JY; Kim JY; Kwon SB; Li Q; Lee HW
+Authors Full Name
+ Jung, Yun-Chan; Kim, Hyun Woo; Min, Bok Kee; Cho, Jae Young; Son, Hyo Jeong; Lee, Ja Young; Kim, Ji-Young; Kwon, Sae-Bom; Li, Qiang; Lee, Hee-Woo.
+Institution
+ Jung, Yun-Chan. Institute of Research and Development, Chaon Corp., Seongnam, Republic of Korea.
+ Kim, Hyun Woo. Institute of Research and Development, Chaon Corp., Seongnam, Republic of Korea.
+ Min, Bok Kee. Nova K Health Corp., Seoul, Republic of Korea.
+ Cho, Jae Young. Nova K Health Corp., Seoul, Republic of Korea.
+ Son, Hyo Jeong. Nova K Health Corp., Seoul, Republic of Korea.
+ Lee, Ja Young. Nova K Health Corp., Seoul, Republic of Korea.
+ Kim, Ji-Young. Nova K Health Corp., Seoul, Republic of Korea.
+ Kwon, Sae-Bom. Nova K Health Corp., Seoul, Republic of Korea.
+ Li, Qiang. Institute of Research and Development, Chaon Corp., Seongnam, Republic of Korea liqiang8589@snu.ac.kr dinks90@chaon.kr.
+ Lee, Hee-Woo. Institute of Research and Development, Chaon Corp., Seongnam, Republic of Korea liqiang8589@snu.ac.kr dinks90@chaon.kr.
+MeSH Subject Headings
+ Adipogenesis/de [Drug Effects]
+ Adipose Tissue/de [Drug Effects]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Anti-Obesity Agents/ch [Chemistry]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers
+ Body Weight/de [Drug Effects]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Lipid Metabolism
+ Male
+ Mice
+ Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ *Olea/ch [Chemistry]
+ Plant Extracts/ch [Chemistry]
+ *Plant Extracts/pd [Pharmacology]
+ *Plant Leaves/ch [Chemistry]
+ Thermogenesis/de [Drug Effects]
+Keyword Heading
+ Obesity
+ adipogenesis
+ fat
+ olive leaf extract
+ thermogenesis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND/AIM: The rapid increase in the number of people who are overweight or obese, which increases the risk of diseases and health problems, is becoming an important issue. Herein, we investigated whether olive leaf extract (OLE) has potent anti-obesity effects in high-fat induced mouse models.
+
+ MATERIALS AND METHODS: C57BL/6 mice were randomized into normal control, high-fat diet (HFD), HFD with OLE, and HFD with garcinia groups and administered experimental diets for 12 weeks. Body weight and food intake were measured once per week and obesity-related biomarkers were evaluated in the serum and adipose tissue.
+
+ RESULTS: OLE significantly suppressed weight gain, food efficiency ratio, visceral fat accumulation, and serum lipid composition in HFD-induced mice. Furthermore, the expression of adipogenesis- and thermogenesis-related molecules was decreased in the OLE-treated group.
+
+ CONCLUSION: OLE prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Plant Extracts).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.21873%2finvivo.11529
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jung&issn=0258-851X&title=In+Vivo&atitle=Inhibitory+Effect+of+Olive+Leaf+Extract+on+Obesity+in+High-fat+Diet-induced+Mice.&volume=33&issue=3&spage=707&epage=715&date=2019&doi=10.21873%2Finvivo.11529&pmid=31028187&sid=OVID:medline
+
+<1694>
+Unique Identifier
+ 31026738
+Title
+ Consumption of Brazil nuts with high selenium levels increased inflammation biomarkers in obese women: A randomized controlled trial.
+Source
+ Nutrition. 63-64:162-168, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Duarte GBS; Reis BZ; Rogero MM; Vargas-Mendez E; Junior FB; Cercato C; Cozzolino SMF
+Authors Full Name
+ Duarte, Graziela Biude Silva; Reis, Bruna Zavarize; Rogero, Marcelo Macedo; Vargas-Mendez, Ernesto; Junior, Fernando Barbosa; Cercato, Cintia; Cozzolino, Silvia Maria Franciscato.
+Institution
+ Duarte, Graziela Biude Silva. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: Gbiude@usp.br.
+ Reis, Bruna Zavarize. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, Brazil.
+ Rogero, Marcelo Macedo. Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, Research Innovation and Dissemination Centers Sao Paulo Research Foundation, Sao Paulo, Brazil.
+ Vargas-Mendez, Ernesto. Department of Biochemistry, School of Medicine, University of Costa Rica, Costa Rica.
+ Junior, Fernando Barbosa. Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
+ Cercato, Cintia. Division of Endocrinology and Metabolism, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
+ Cozzolino, Silvia Maria Franciscato. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, Brazil.
+MeSH Subject Headings
+ Adult
+ Bertholletia/ch [Chemistry]
+ *Bertholletia
+ Biomarkers/bl [Blood]
+ *Diet/ae [Adverse Effects]
+ Diet/mt [Methods]
+ Eating/ph [Physiology]
+ Female
+ Humans
+ Inflammation
+ *Inflammation Mediators/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ Selenium/ad [Administration & Dosage]
+ *Selenium/bl [Blood]
+ Young Adult
+Keyword Heading
+ Brazil nut
+ Inflammation
+ Metabolic inflammation
+ Obesity
+ Selenium
+ Selenoprotein P
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Increased inflammatory response is an important factor in the pathophysiology of obesity. The mineral selenium (Se), of which one of the main food sources is the Brazil nut, has important antioxidant and anti-inflammatory functions through the action of selenoproteins. Thus, the evaluation of the influence of this micronutrient in this context is of great relevance. The aim of this study was to evaluate the effects of Brazil nut intake with high Se concentrations on inflammatory biomarkers and its relation to Se status in obese women.
+
+ METHODS: A randomized controlled clinical trial was carried out with 55 women recruited at Clinical Hospital in Sao Paulo, Brazil. Patients were randomly assigned to either the Brazil nut group (BN) or the control group (CO) and followed up for 2 mo. The BN group consumed 1 unit/d of Brazil nuts (~ 1261 mug/Se); the CO group did not receive any intervention. At baseline and after 2 mo, analysis of biochemical parameters related to Se status, oxidative stress, and inflammatory biomarkers were performed.
+
+ RESULTS: At baseline, both groups did not present Se deficiency. In the BN group, a significant increase (P < 0.05) in all Se biomarkers and in gene expression of several proinflammatory parameters (interleukin-6, tumor necrosis factor-alpha, and Toll-like receptors 2 and 4) were observed after the intervention period. No changes were observed for the CO group.
+
+ CONCLUSION: Although there were no changes in plasma inflammatory biomarkers levels, a significant increase in gene expression may be an indication of a proinflammatory stimulus in obesity, induced by the consumption of Brazil nuts with high Se levels. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). H6241UJ22B (Selenium).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.nut.2019.02.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Duarte&issn=0899-9007&title=Nutrition&atitle=Consumption+of+Brazil+nuts+with+high+selenium+levels+increased+inflammation+biomarkers+in+obese+women%3A+A+randomized+controlled+trial.&volume=63-64&issue=&spage=162&epage=168&date=2019&doi=10.1016%2Fj.nut.2019.02.009&pmid=31026738&sid=OVID:medline
+
+<1695>
+Unique Identifier
+ 31022246
+Title
+ Aerobic exercise training prevents obesity and insulin resistance independent of the renin angiotensin system modulation in the subcutaneous white adipose tissue.
+Source
+ PLoS ONE [Electronic Resource]. 14(4):e0215896, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Americo ALV; Muller CR; Vecchiatto B; Martucci LF; Fonseca-Alaniz MH; Evangelista FS
+Authors Full Name
+ Americo, Anna Laura V; Muller, Cynthia R; Vecchiatto, Bruno; Martucci, Luiz Felipe; Fonseca-Alaniz, Miriam H; Evangelista, Fabiana S.
+Institution
+ Americo, Anna Laura V. Department of Experimental Pathophysiology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
+ Muller, Cynthia R. Department of Experimental Pathophysiology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
+ Vecchiatto, Bruno. School of Arts, Science and Humanities, University of Sao Paulo, Sao Paulo, Brazil.
+ Martucci, Luiz Felipe. Department of Experimental Pathophysiology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
+ Fonseca-Alaniz, Miriam H. Heart Institute (InCor), Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
+ Evangelista, Fabiana S. School of Arts, Science and Humanities, University of Sao Paulo, Sao Paulo, Brazil.
+MeSH Subject Headings
+ *Adipose Tissue, White/me [Metabolism]
+ Adiposity
+ Angiotensin I/me [Metabolism]
+ Angiotensin II/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight
+ Feeding Behavior
+ Glucose/me [Metabolism]
+ *Insulin Resistance
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ *Obesity/pc [Prevention & Control]
+ Peptide Fragments/me [Metabolism]
+ Peptides/bl [Blood]
+ *Physical Conditioning, Animal
+ RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+ *Renin-Angiotensin System
+ *Subcutaneous Fat/me [Metabolism]
+ Thermogenesis
+ Uncoupling Protein 1/me [Metabolism]
+Abstract
+ We investigate the effects of aerobic exercise training (AET) on the thermogenic response, substrate metabolism and renin angiotensin system (RAS) in the subcutaneous white adipose tissue (SC-WAT) of mice fed cafeteria diet (CAF). Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n = 10), CHOW-TR (chow diet, trained; n = 10), CAF-SED (CAF, sedentary; n = 10) and CAF-TR (CAF, trained; n = 10). AET consisted in running sessions of 60 min at 60% of maximal speed, five days per week for eight weeks. The CAF-SED group showed higher body weight and adiposity, glucose intolerance and insulin resistance (IR), while AET prevented such damages in CAF-TR group. AET reduced the p-AKT/t-AKT ratio and increased ATGL expression in CHOW-TR and CAF-TR groups and increased t-HSL and p-HSL/t-HSL ratio in CAF-TR. AET prevented adipocyte hypertrophy in CAF-TR group and increased UCP-1 protein expression only in CHOW-TR. Serum ACE2 increased in CHOW-TR and CAF-TR groups, and Ang (1-7) increased in the CHOW-TR group. In the SC-WAT, CAF-TR group increased the expression of AT1, AT2 and Mas receptors, whereas CHOW-TR increased Ang (1-7) and Ang (1-7)/Ang II ratio in SC-WAT. No changes were observed in ACE and Ang II. Positive correlations were observed between UCP-1 and kITT (r = 0.6), between UCP-1 and Ang (1-7) concentration (r = 0.6), and between UCP-1 and Ang (1-7)/Ang II ratio (r = 0.7). In conclusion, the AET prevented obesity and IR, reduced insulin signaling proteins and increased lipolysis signaling proteins in the SC-WAT. In addition, the CAF diet precludes the AET-induced thermogenic response and the partial modulation of the RAS suggests that the protective effect of AET against obesity and IR could not be associated with SC-WAT RAS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (Peptides). 0 (RNA, Messenger). 0 (Uncoupling Protein 1). 11128-99-7 (Angiotensin II). 9041-90-1 (Angiotensin I). IJ3FUK8MOF (angiotensin I (1-7)). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0215896
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Americo&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Aerobic+exercise+training+prevents+obesity+and+insulin+resistance+independent+of+the+renin+angiotensin+system+modulation+in+the+subcutaneous+white+adipose+tissue.&volume=14&issue=4&spage=e0215896&epage=&date=2019&doi=10.1371%2Fjournal.pone.0215896&pmid=31022246&sid=OVID:medline
+
+<1696>
+Unique Identifier
+ 31014098
+Title
+ Bariatric surgery as a model to explore the basis and consequences of the Reaven hypothesis: Small, dense low-density lipoprotein and interleukin-6.
+Source
+ Diabetes & Vascular Disease Research. 16(2):144-152, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adam S; Liu Y; Siahmansur T; Ho JH; Dhage SS; Yadav R; New JP; Donn R; Ammori BJ; Syed AA; Malik RA; Soran H; Durrington PN
+Author NameID
+ Adam, Safwaan; ORCID: https://orcid.org/0000-0001-8004-1897
+Authors Full Name
+ Adam, Safwaan; Liu, Yifen; Siahmansur, Tarza; Ho, Jan H; Dhage, Shaishav S; Yadav, Rahul; New, John P; Donn, Rachelle; Ammori, Basil J; Syed, Akheel A; Malik, Rayaz A; Soran, Handrean; Durrington, Paul N.
+Institution
+ Adam, Safwaan. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Adam, Safwaan. 2 Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Manchester, UK.
+ Siahmansur, Tarza. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Ho, Jan H. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Ho, Jan H. 2 Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Manchester, UK.
+ Dhage, Shaishav S. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Dhage, Shaishav S. 2 Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Manchester, UK.
+ Yadav, Rahul. 3 Department of Diabetes and Endocrinology, Warrington and Halton Hospitals NHS Foundation Trust, Warrington, UK.
+ New, John P. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ New, John P. 4 Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Salford, UK.
+ Donn, Rachelle. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Ammori, Basil J. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Ammori, Basil J. 5 Department of Surgery, Salford Royal NHS Foundation Trust, Salford, UK.
+ Syed, Akheel A. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Syed, Akheel A. 4 Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Salford, UK.
+ Malik, Rayaz A. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Malik, Rayaz A. 6 Weill-Cornell Medicine-Qatar, Doha, Qatar.
+ Soran, Handrean. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+ Soran, Handrean. 2 Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Manchester, UK.
+ Durrington, Paul N. 1 Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Female
+ *Gastric Bypass/mt [Methods]
+ Humans
+ Insulin/bl [Blood]
+ *Insulin Resistance
+ *Interleukin-6/bl [Blood]
+ *Laparoscopy
+ *Lipoproteins, LDL/bl [Blood]
+ Male
+ Middle Aged
+ *Models, Biological
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/su [Surgery]
+ Particle Size
+ Prospective Studies
+ Time Factors
+ Treatment Outcome
+ *Weight Loss
+Keyword Heading
+ Insulin resistance
+ Reaven's hypothesis
+ bariatric surgery
+ metabolic syndrome
+ obesity
+ triglycerides
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Reaven originally described the clustering of insulin resistance/hyperinsulinaemia, obesity (particularly visceral), altered cytokine levels, glucose intolerance, hypertriglyceridaemia and low high-density lipoprotein cholesterol. Subsequently, a potentially highly atherogenic small, dense low-density lipoprotein was also reported. We have studied the effect of bariatric surgery on this and other risk factors for atherosclerosis.
+
+ METHODS: Forty patients (20 with type 2 diabetes mellitus) undergoing bariatric surgery were studied before and 1 year after bariatric surgery.
+
+ RESULTS: Twelve months after bariatric surgery, median body mass index had decreased from 49.5 to 36.5 kg/m2, fasting insulin from 21.3 to 7.8 mU/L and insulin resistance (homeostatic model assessment of insulin resistance) from 5.9 to 1.8 (all p < 0.001). Thirteen out of 20 patients had remission from type 2 diabetes mellitus. Highly sensitive C-reactive protein, interleukin-6, fasting triglycerides ( p < 0.001) and small, dense low-density lipoprotein ( p < 0.001) decreased, while high-density lipoprotein cholesterol increased ( p < 0.001) significantly, irrespective of having type 2 diabetes mellitus and/or being treated with statin therapy before surgery.
+
+ CONCLUSION: The association between marked weight loss and change in insulin resistance and hyperinsulinaemia with the change in small, dense low-density lipoprotein and interleukin-6 warrants further investigation. Bariatric surgery provides a model for investigating the mechanisms linking insulin resistance/hyperinsulinaemia to atherosclerosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (IL6 protein, human). 0 (Insulin). 0 (Interleukin-6). 0 (Lipoproteins, LDL). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1177%2f1479164119826479
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adam&issn=1479-1641&title=Diabetes+%26+Vascular+Disease+Research&atitle=Bariatric+surgery+as+a+model+to+explore+the+basis+and+consequences+of+the+Reaven+hypothesis%3A+Small%2C+dense+low-density+lipoprotein+and+interleukin-6.&volume=16&issue=2&spage=144&epage=152&date=2019&doi=10.1177%2F1479164119826479&pmid=31014098&sid=OVID:medline
+
+<1697>
+Unique Identifier
+ 31011773
+Title
+ Gray matter reduction related to decreased serum creatinine and increased triglyceride, Hemoglobin A1C, and low-density lipoprotein in subjects with obesity.
+Source
+ Neuroradiology. 61(6):703-710, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shan H; Li P; Liu H; Nie B; Yin X; Zhang T; Sun X; Zhang W; Feng T; Wang L; Hu Y; Dong G; Gao H; Du J; Ma L; Li D; Shan B
+Author NameID
+ Shan, Baoci; ORCID: http://orcid.org/0000-0001-8543-9722
+Authors Full Name
+ Shan, Han; Li, Panlong; Liu, Hua; Nie, Binbin; Yin, Xiaolong; Zhang, Tianhao; Sun, Xi; Zhang, Wei; Feng, Ting; Wang, Luying; Hu, Yichao; Dong, Guanglong; Gao, Hongkai; Du, Jin; Ma, Lin; Li, Demin; Shan, Baoci.
+Institution
+ Shan, Han. Department of Radiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China.
+ Li, Panlong. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China.
+ Li, Panlong. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Liu, Hua. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Nie, Binbin. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Yin, Xiaolong. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China.
+ Yin, Xiaolong. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Zhang, Tianhao. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Sun, Xi. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China.
+ Sun, Xi. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Zhang, Wei. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Feng, Ting. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China.
+ Feng, Ting. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Wang, Luying. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China.
+ Wang, Luying. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
+ Hu, Yichao. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China.
+ Dong, Guanglong. Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
+ Gao, Hongkai. Department of General Surgery, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, China.
+ Du, Jin. Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China.
+ Ma, Lin. Department of Radiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China.
+ Li, Demin. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China.
+ Shan, Baoci. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. shanbc@mail.ihep.ac.cn.
+ Shan, Baoci. School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China. shanbc@mail.ihep.ac.cn.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ *Creatinine/bl [Blood]
+ Female
+ *Glycated Hemoglobin/me [Metabolism]
+ Gray Matter/dg [Diagnostic Imaging]
+ *Gray Matter/pa [Pathology]
+ Humans
+ *Lipoproteins, LDL/bl [Blood]
+ Longitudinal Studies
+ *Magnetic Resonance Imaging/mt [Methods]
+ Male
+ *Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Organ Size
+ *Triglycerides/bl [Blood]
+Keyword Heading
+ Creatinine
+ Gray matter volume
+ HbA1c
+ Low-density lipoprotein
+ Obesity
+ Triglyceride
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Altered brain volume and metabolic variables have been found in subjects with obesity. However, the role of metabolic parameters in gray matter volume (GMV) has been poorly investigated. This study aimed to investigate the relationship between the metabolic parameters and brain volume in subjects with obesity.
+
+ METHODS: Thirty-seven subjects with obesity and 39 age and sex matched normal-weight controls were included in this study. Eighteen of the 37 participants who underwent sleeve gastrectomy were included in the longitudinal analysis. Blood samples and high-resolution 3T T1-weighted magnetic resonance images were collected. Metabolic parameters in plasma and GMV were measured.
+
+ RESULTS: Multiple linear regression analysis showed that gray matter reduction in several cognition-related cortices including right angular gyrus, superior occipital cortex, superior parietal cortex, and cerebellum was related to decreased creatinine, as well as increased triglyceride, HbA1c, and low-density lipoprotein in plasma in subjects with obesity. Weight loss after the surgery induced significant recovery of altered metabolic parameters and decreased gray matter volume. Furthermore, changes in the four metabolic parameters before and after the surgery were associated with changes in gray matter volume.
+
+ CONCLUSION: Our results suggest that the gray matter reduction is related to decreased creatinine as well as increased triglyceride, HbA1c, and low-density lipoprotein in plasma in subjects with obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Lipoproteins, LDL). 0 (Triglycerides). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00234-019-02202-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shan&issn=0028-3940&title=Neuroradiology&atitle=Gray+matter+reduction+related+to+decreased+serum+creatinine+and+increased+triglyceride%2C+Hemoglobin+A1C%2C+and+low-density+lipoprotein+in+subjects+with+obesity.&volume=61&issue=6&spage=703&epage=710&date=2019&doi=10.1007%2Fs00234-019-02202-3&pmid=31011773&sid=OVID:medline
+
+<1698>
+Unique Identifier
+ 31010086
+Title
+ Plasma Transthyretin as A Biomarker of Sarcopenia in Elderly Subjects. [Review]
+Source
+ Nutrients. 11(4), 2019 Apr 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ingenbleek Y
+Author NameID
+ Ingenbleek, Yves; ORCID: https://orcid.org/0000-0002-1482-7143
+Authors Full Name
+ Ingenbleek, Yves.
+Institution
+ Ingenbleek, Yves. Laboratory of Nutrition, Faculty of Pharmacy, University Louis Pasteur, F-67401 Strasbourg, France. ingen@unistra.fr.
+MeSH Subject Headings
+ Adipose Tissue
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Composition
+ *Body Fluid Compartments/me [Metabolism]
+ Body Mass Index
+ Humans
+ Inflammation/bl [Blood]
+ Liver/me [Metabolism]
+ *Muscle, Skeletal/me [Metabolism]
+ Nutritional Status
+ Obesity/co [Complications]
+ Prealbumin/bi [Biosynthesis]
+ *Prealbumin/me [Metabolism]
+ Protein Deficiency/bl [Blood]
+ *Sarcopenia/bl [Blood]
+Keyword Heading
+ diagnosis
+ elderly persons
+ inflammation
+ lean body mass
+ malnutrition
+ outcome
+ prognosis
+ sarcopenia
+ transthyretin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Skeletal muscle (SM) mass, the chief component of the structural compartment belonging to lean body mass (LBM), undergoes sarcopenia with increasing age. Decreased SM in elderly persons is a naturally occurring process that may be accelerated by acute or chronic nutritional deficiencies and/or inflammatory disorders, declining processes associated with harmful complications. A recently published position paper by European experts has provided an overall survey on the definition and diagnosis of sarcopenia in elderly persons. The present review describes the additional contributory role played by the noninvasive transthyretin (TTR) micromethod. The body mass index (BMI) formula is currently used in clinical studies as a criterion of good health to detect, prevent, and follow up on the downward trend of muscle mass. The recent upsurge of sarcopenic obesity with its multiple subclasses has led to a confused stratification of SM and fat stores, prompting workers to eliminate BMI from screening programs. As a result, investigators are now focusing on indices of protein status that participate in SM growth, maturation, and catabolism that might serve to identify sarcopenia trajectories. Plasma TTR is clearly superior to all other hepatic biomarkers, showing the same evolutionary patterns as those displayed in health and disease by both visceral and structural LBM compartments. As a result, this TTR parameter maintains positive correlations with muscle mass downsizing in elderly persons. The liver synthesis of TTR is downregulated in protein-depleted states and suppressed in cytokine-induced inflammatory disorders. TTR integrates the centrally-mediated regulatory mechanisms governing the balance between protein accretion and protein breakdown, emerging as the ultimate indicator of LBM resources. This review proposes the adoption of a gray zone defined by cut-off values ranging from 200 mg/L to 100 mg/L between which TTR plasma values may fluctuate and predict either the best or the worst outcome. The best outcome occurs when appropriate dietary, medicinal and surgical decisions are undertaken, resuming TTR synthesis which manifests rising trends towards pre-stress levels. The worst occurs when all therapeutic means fail to succeed, leading inevitably to complete exhaustion of LBM and SM metabolic resources with an ensuing fatal outcome. Some patients may remain unresponsive in the middle of the gray area, combining steady clinical states with persistent stagnant TTR values. Using the serial measurement of plasma TTR values, these last patients should be treated with the most aggressive and appropriate therapeutic strategies to ensure the best outcome.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Prealbumin).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11040895
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ingenbleek&issn=2072-6643&title=Nutrients&atitle=Plasma+Transthyretin+as+A+Biomarker+of+Sarcopenia+in+Elderly+Subjects.&volume=11&issue=4&spage=&epage=&date=2019&doi=10.3390%2Fnu11040895&pmid=31010086&sid=OVID:medline
+
+<1699>
+Unique Identifier
+ 31004153
+Title
+ Long-Term Change in both Dietary Insulinemic and Inflammatory Potential Is Associated with Weight Gain in Adult Women and Men.
+Source
+ Journal of Nutrition. 149(5):804-815, 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tabung FK; Satija A; Fung TT; Clinton SK; Giovannucci EL
+Authors Full Name
+ Tabung, Fred K; Satija, Ambika; Fung, Teresa T; Clinton, Steven K; Giovannucci, Edward L.
+Institution
+ Tabung, Fred K. Division of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH.
+ Tabung, Fred K. The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH.
+ Tabung, Fred K. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Satija, Ambika. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Fung, Teresa T. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Fung, Teresa T. Department of Nutrition, Simmons University, Boston, MA.
+ Clinton, Steven K. Division of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH.
+ Clinton, Steven K. The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH.
+ Giovannucci, Edward L. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
+ Giovannucci, Edward L. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Diet
+ Energy Intake
+ *Feeding Behavior
+ Female
+ Follow-Up Studies
+ Humans
+ Hyperinsulinism/bl [Blood]
+ *Hyperinsulinism/co [Complications]
+ Inflammation/bl [Blood]
+ *Inflammation/co [Complications]
+ *Insulin/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/et [Etiology]
+ Obesity/pc [Prevention & Control]
+ Prospective Studies
+ Sex Factors
+ *Weight Gain
+Keyword Heading
+ dietary patterns
+ inflammatory diets
+ insulinemic diets
+ weight change
+ weight gain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The influence of long-term dietary patterns on weight gain and the underlying potential biological mechanisms are not fully understood.
+
+ OBJECTIVE: We prospectively examined the association of changes in 2 empirical hypothesis-oriented dietary patterns (insulinemic and inflammatory) and weight gain over 24 y at 4-y intervals.
+
+ METHODS: We followed 54,397 women in the Nurses' Health Study and 33,043 men in the Health Professionals Follow-Up Study (1986-2010), and computed the empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) scores from food frequency questionnaires administered every 4 y. Both scores are weighted sums of 18 food groups, which characterize dietary insulinemic or inflammatory potential based on plasma levels of insulin response or inflammatory biomarkers. We used multivariable-adjusted linear regression to examine 4-y changes in the dietary scores and weight change within the same period.
+
+ RESULTS: The mean baseline body mass index (BMI, in kg/m2) was 25.4. Compared with participants who made minimal dietary changes (quintile 3) over 6 4-y periods; participants who changed their diets toward lower insulinemic or inflammatory potential (quintile 1) gained significantly less weight (in kilograms per 4 y) independent of total energy intake, BMI, physical activity, and smoking status: EDIH: -0.65 (95% CI: -0.73, -0.57), EDIP: -0.29 (-0.37, -0.21) among women; and EDIH: -0.60 (-0.71, -0.49), EDIP: -0.19 (-0.27, -0.07) among men. In contrast, those who changed their diets toward higher insulinemic or inflammatory potential (quintile 5) gained significantly more weight: EDIH: 0.43 (0.36, 0.51), EDIP: 0.15 (0.07, 0.23) among women; and EDIH: 0.49 (0.38, 0.59), EDIP: 0.22 (0.11, 0.33) among men (P-trend < 0.0001 for all comparisons). Associations were stronger among individuals who were overweight or obese, younger, less physically active, and had never smoked.
+
+ CONCLUSIONS: High dietary insulinemic and inflammatory potential is associated with substantial long-term weight gain in adult men and women independent of total energy intake. Dietary patterns with low insulinemic and inflammatory potential may aid in weight gain prevention. Copyright © American Society for Nutrition 2019.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fjn%2fnxy319
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tabung&issn=0022-3166&title=Journal+of+Nutrition&atitle=Long-Term+Change+in+both+Dietary+Insulinemic+and+Inflammatory+Potential+Is+Associated+with+Weight+Gain+in+Adult+Women+and+Men.&volume=149&issue=5&spage=804&epage=815&date=2019&doi=10.1093%2Fjn%2Fnxy319&pmid=31004153&sid=OVID:medline
+
+<1700>
+Unique Identifier
+ 31003058
+Title
+ Associations between urinary organophosphate ester metabolites and measures of adiposity among U.S. children and adults: NHANES 2013-2014.
+Source
+ Environment International. 127:754-763, 2019 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Boyle M; Buckley JP; Quiros-Alcala L
+Authors Full Name
+ Boyle, M; Buckley, J P; Quiros-Alcala, L.
+Institution
+ Boyle, M. Maryland Institute of Applied Environmental Health, School of Public Health, University of Maryland, College Park, MD, USA.
+ Buckley, J P. Johns Hopkins University, Department of Environmental Health & Engineering, Department of Epidemiology, Baltimore, MD, USA.
+ Quiros-Alcala, L. Maryland Institute of Applied Environmental Health, School of Public Health, University of Maryland, College Park, MD, USA. Electronic address: lquiros@umd.edu.
+MeSH Subject Headings
+ *Adiposity/de [Drug Effects]
+ Adult
+ Biomarkers/ur [Urine]
+ Body Mass Index
+ Child
+ Cross-Sectional Studies
+ Female
+ Flame Retardants/me [Metabolism]
+ Humans
+ Male
+ *Nutrition Surveys
+ Obesity
+ *Organophosphates/me [Metabolism]
+ *Organophosphates/ur [Urine]
+ Overweight/ep [Epidemiology]
+ Overweight/ur [Urine]
+ Prospective Studies
+ United States/ep [Epidemiology]
+ Waist Circumference
+Keyword Heading
+ Adiposity
+ Adults
+ Body mass index
+ Children
+ Flame retardants
+ Organophosphate esters
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Organophosphate esters (OPEs) are synthetic chemicals found in many consumer products, including furniture, electronics, processed foods, and building materials. Emerging in vitro and in vivo studies suggest that OPEs are metabolism disrupting compounds; however, epidemiologic studies investigating their associations with adiposity markers are sparse.
+
+ OBJECTIVE: We examined cross-sectional associations between OPE biomarkers and adiposity measures among U.S. children and adults participating in the National Health and Nutrition Examination Survey (NHANES: 2013-2014).
+
+ METHODS: Concentrations of five OPE metabolites were quantified in urine: diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), bis(2-chloroethyl) phosphate (BCEP), dibutyl phosphate (DBUP), and bis(1-chloro-2-propyl) phosphate (BCPP). We conducted covariate-adjusted logistic and linear regressions to examine associations between log2-transformed and dichotomized OPE metabolite concentrations and obesity, body mass index (BMI), and waist circumference (WC), separately among 784 children (6-19years) and 1672 adults (>=20years). We also assessed heterogeneity of associations by sex.
+
+ RESULTS: DBUP concentrations were inversely associated with the prevalence odds of being obese vs. normal weight in children (adjusted Prevalence Odds Ratio, aPOR: 0.82, 95% Confidence Interval, 95% CI: 0.70, 0.95) and adults (aPOR: 0.83, 95% CI: 0.72, 0.96). DBUP was also significantly associated with lower BMI z-scores (beta:-0.08, 95% CI:-0.17, 0.01) and WC (beta:-0.71, 95% CI: -1.49, 0.07) in children. BCEP concentrations were associated with increased prevalence odds of being overweight vs. normal weight (aPOR: 1.15, 95% CI: 1.01, 1.32) among children; similar, albeit not statistically significant, relationships were observed with other child adiposity outcomes. Among adults, detectable BCPP concentrations were associated with increased prevalence odds of being obese vs. normal weight (aPOR: 1.70, 95% CI: 1.21, 2.38) and having a high vs. normal WC (aPOR: 1.51, 95% CI: 1.11, 2.07) as well as higher BMI (beta: 1.31, 95% CI: 0.30, 2.33). Other OPE metabolites were not consistently associated with adiposity measures among adults. Although associations of BCPP exposure with adiposity outcomes were generally inverse among boys, but not girls, we did not observe consistent evidence of sexually-dimorphic associations for other OPE metabolites.
+
+ CONCLUSIONS: Exposure to select OPEs may be differentially associated with body size among children and adults. Given the cross-sectional design of the present study, future prospective studies are needed to confirm these findings. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Flame Retardants). 0 (Organophosphates).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.envint.2019.03.055
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Boyle&issn=0160-4120&title=Environment+International&atitle=Associations+between+urinary+organophosphate+ester+metabolites+and+measures+of+adiposity+among+U.S.+children+and+adults%3A+NHANES+2013-2014.&volume=127&issue=&spage=754&epage=763&date=2019&doi=10.1016%2Fj.envint.2019.03.055&pmid=31003058&sid=OVID:medline
+
+<1701>
+Unique Identifier
+ 30999596
+Title
+ High-Fat Breakfast Meal Replacement in Overweight and Obesity: Implications on Body Composition, Metabolic Markers, and Satiety.
+Source
+ Nutrients. 11(4), 2019 Apr 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Smith-Ryan AE; Hirsch KR; Blue MNM; Mock MG; Trexler ET
+Author NameID
+ Smith-Ryan, Abbie E; ORCID: https://orcid.org/0000-0002-5405-304X
+Authors Full Name
+ Smith-Ryan, Abbie E; Hirsch, Katie R; Blue, Malia N M; Mock, Meredith G; Trexler, Eric T.
+Institution
+ Smith-Ryan, Abbie E. Applied Physiology Laboratory, Department of Exercise and Sport Science, The University of North Carolina, Chapel Hill, NC 27599, USA. abbsmith@email.unc.edu.
+ Smith-Ryan, Abbie E. Human Movement Science Curriculum, Department of Allied Health Science, University of North Carolina, Chapel Hill, NC 27599, USA. abbsmith@email.unc.edu.
+ Hirsch, Katie R. Applied Physiology Laboratory, Department of Exercise and Sport Science, The University of North Carolina, Chapel Hill, NC 27599, USA. ktrose23@live.unc.edu.
+ Hirsch, Katie R. Human Movement Science Curriculum, Department of Allied Health Science, University of North Carolina, Chapel Hill, NC 27599, USA. ktrose23@live.unc.edu.
+ Blue, Malia N M. Applied Physiology Laboratory, Department of Exercise and Sport Science, The University of North Carolina, Chapel Hill, NC 27599, USA. mnm3303@live.unc.edu.
+ Blue, Malia N M. Human Movement Science Curriculum, Department of Allied Health Science, University of North Carolina, Chapel Hill, NC 27599, USA. mnm3303@live.unc.edu.
+ Mock, Meredith G. Applied Physiology Laboratory, Department of Exercise and Sport Science, The University of North Carolina, Chapel Hill, NC 27599, USA. mock.mere@gmail.com.
+ Trexler, Eric T. Applied Physiology Laboratory, Department of Exercise and Sport Science, The University of North Carolina, Chapel Hill, NC 27599, USA. trexlere@live.unc.edu.
+ Trexler, Eric T. Human Movement Science Curriculum, Department of Allied Health Science, University of North Carolina, Chapel Hill, NC 27599, USA. trexlere@live.unc.edu.
+MeSH Subject Headings
+ Adipose Tissue
+ Adult
+ Biomarkers/bl [Blood]
+ *Body Composition/de [Drug Effects]
+ *Breakfast
+ *Dietary Fats/ad [Administration & Dosage]
+ *Energy Metabolism/de [Drug Effects]
+ Female
+ Humans
+ Intra-Abdominal Fat
+ Male
+ Obesity/dh [Diet Therapy]
+ *Obesity/me [Metabolism]
+ *Satiation
+Keyword Heading
+ fat mass
+ medium chain triglyceride
+ metabolic rate
+ obese
+ overweight
+ supplement
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The purpose of this paper was to determine the effect of replacing breakfast with a high-fat drink on fat mass (FM), lean mass (LM), percent body fat (%BF), visceral fat (VAT), resting metabolic rate (RMR), fuel utilization (RER), blood lipids and satiety in overweight and obese adults. Healthy adults (n = 42; 21 Females; body mass index (BMI): 32.8 +/- 4.6 kg.m-2) were randomized to control (CON; n = 21) or meal replacement (MRP; n = 22) groups. Body composition was measured using a four-compartment model; RMR and RER were assessed from indirect calorimetry. The MRP (70% fat) was consumed once daily for eight weeks. For males, there was no change (p > 0.05) in FM (mean difference (MD) = 0.41 +/- 1.19 kg], %BF MD = 0.50 +/- 1.09%, LM MD = -0.64 +/- 1.79 kg, or VAT MD = -0.31 +/- 1.36 cm for MRP versus CON. Similarly, no differences for females for FM MD = -0.73 +/- 1.37 kg, %BF MD = -0.57 +/- 1.26%, LM MD = 0.31 +/- 1.37 kg, or VAT MD: -0.83 +/- 1.2 cm. HDL was significantly reduced in the MRP group for females (adjusted mean change: -6.41 +/- 4.44 units, p = 0.018). There was no effect on RMR or RER. Satiety increased in the afternoon for MRP (p = 0.021). Despite high fat, no negative impact on lipids resulted; increased satiety may be beneficial for controlling afternoon cravings, but does not affect body composition.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fats).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11040865
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Smith-Ryan&issn=2072-6643&title=Nutrients&atitle=High-Fat+Breakfast+Meal+Replacement+in+Overweight+and+Obesity%3A+Implications+on+Body+Composition%2C+Metabolic+Markers%2C+and+Satiety.&volume=11&issue=4&spage=&epage=&date=2019&doi=10.3390%2Fnu11040865&pmid=30999596&sid=OVID:medline
+
+<1702>
+Unique Identifier
+ 30994716
+Title
+ Biomarker-based Inflammatory Score in Obese Patients with Resistant Hypertension.
+Source
+ Arquivos Brasileiros de Cardiologia. 112(4):390-391, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rodrigues CIS
+Author NameID
+ Rodrigues, Cibele Isaac Saad; ORCID: https://orcid.org/0000-0001-9490-7997
+Authors Full Name
+ Rodrigues, Cibele Isaac Saad.
+Institution
+ Rodrigues, Cibele Isaac Saad. Pontificia Universidade Catolica, Sao Paulo, SP - Brazil.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ *Adipokines
+ Biomarkers
+ Cytokines
+ Humans
+ *Hypertension
+ Obesity
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.5935%2fabc.20190051
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rodrigues&issn=0066-782X&title=Arquivos+Brasileiros+de+Cardiologia&atitle=Biomarker-based+Inflammatory+Score+in+Obese+Patients+with+Resistant+Hypertension.&volume=112&issue=4&spage=390&epage=391&date=2019&doi=10.5935%2Fabc.20190051&pmid=30994716&sid=OVID:medline
+
+<1703>
+Unique Identifier
+ 30993789
+Title
+ Impact of combined healthy lifestyle factors on survival in an adult general population and in high-risk groups: prospective results from the Moli-sani Study.
+Source
+ Journal of Internal Medicine. 286(2):207-220, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bonaccio M; Di Castelnuovo A; Costanzo S; De Curtis A; Persichillo M; Cerletti C; Donati MB; de Gaetano G; Iacoviello L
+Author NameID
+ Bonaccio, M; ORCID: https://orcid.org/0000-0002-8082-6552
+Corporate Author
+ Moli-sani Study Investigators
+Authors Full Name
+ Bonaccio, M; Di Castelnuovo, A; Costanzo, S; De Curtis, A; Persichillo, M; Cerletti, C; Donati, M B; de Gaetano, G; Iacoviello, L.
+Institution
+ Bonaccio, M. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
+ Di Castelnuovo, A. Mediterranea, Cardiocentro, Napoli, Italy.
+ Costanzo, S. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
+ De Curtis, A. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
+ Persichillo, M. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
+ Cerletti, C. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
+ Donati, M B. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
+ de Gaetano, G. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
+ Iacoviello, L. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
+ Iacoviello, L. Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Cardiovascular Diseases/mo [Mortality]
+ Diabetes Mellitus/mo [Mortality]
+ Diet, Mediterranean
+ Exercise
+ Female
+ *Healthy Lifestyle
+ Humans
+ Italy
+ Longitudinal Studies
+ Male
+ *Mortality/td [Trends]
+ Obesity
+ Prospective Studies
+ Risk Factors
+ Smoking Cessation
+Keyword Heading
+ biomarkers
+ cardiovascular risk
+ cardiovascular subjects
+ diabetes
+ elderly
+ high-risk groups
+ inflammation
+ lifestyle factors
+ survival
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: There is poor knowledge on the association between combined lifestyles with mortality risk among individuals at high risk, and little is known on the biological mechanisms that could be on the pathway.
+
+ METHODS: Longitudinal analysis on 22 839 individuals from the Moli-sani Study (Italy, 2005-2010). Among them, we identified 5200 elderly individuals (>=65 year), 2127 subjects with diabetes and 1180 with cardiovascular disease (CVD) at baseline. A healthy lifestyle score (HLS) was calculated, allocating 1 point for each of the following: abstention from smoking; adherence to Mediterranean diet; physical activity; absence of abdominal obesity. Hazard ratios (HR) with 95% confidence intervals (95%CI) were calculated by multivariable Cox regression and competing risk models.
+
+ RESULTS: During 8.2 years of follow-up, 1237 deaths occurred. In the general population, adherence to all four healthy lifestyles, compared with none or 1, was associated with lower risk of all-cause (HR = 0.53; 95%CI:0.39-0.72), CVD (HR = 0.54; 0.32-0.91), cancer (HR = 0.62; 0.39-1.00) and mortality from other causes (HR = 0.39; 0.19-0.81). A 1-point increase in HLS was associated with 20%, 22% and 24% lower risk of total mortality among the elderly, in subjects with diabetes or CVD, respectively. Traditional (e.g. blood lipids), inflammatory (e.g. C-reactive protein) and novel biomarkers (e.g. markers of cardiac damage) accounted for up to 24% of the association of HLS with all-cause mortality risk in the general population.
+
+ CONCLUSIONS: The impact of combined four healthy lifestyles on survival was considerable, both in the general population and among high-risk subgroups. Inflammatory and novel biomarkers of CVD risk explained a substantial proportion of this association. Copyright © 2019 The Association for the Publication of the Journal of Internal Medicine.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fjoim.12907
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bonaccio&issn=0954-6820&title=Journal+of+Internal+Medicine&atitle=Impact+of+combined+healthy+lifestyle+factors+on+survival+in+an+adult+general+population+and+in+high-risk+groups%3A+prospective+results+from+the+Moli-sani+Study.&volume=286&issue=2&spage=207&epage=220&date=2019&doi=10.1111%2Fjoim.12907&pmid=30993789&sid=OVID:medline
+
+<1704>
+Unique Identifier
+ 30990364
+Title
+ Circulating microRNAs in human obesity: a systematic review.
+Source
+ Biomarkers. 24(6):499-509, 2019 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ortiz-Dosal A; Rodil-Garcia P; Salazar-Olivo LA
+Authors Full Name
+ Ortiz-Dosal, Alejandra; Rodil-Garcia, Patricia; Salazar-Olivo, Luis A.
+Institution
+ Ortiz-Dosal, Alejandra. a Division of Molecular Biology, Institute Potosino of Scientific and Technological Research, San Luis Potosi, Mexico.
+ Rodil-Garcia, Patricia. a Division of Molecular Biology, Institute Potosino of Scientific and Technological Research, San Luis Potosi, Mexico.
+ Salazar-Olivo, Luis A. a Division of Molecular Biology, Institute Potosino of Scientific and Technological Research, San Luis Potosi, Mexico.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ Child
+ Circulating MicroRNA/bl [Blood]
+ Circulating MicroRNA/cl [Classification]
+ *Circulating MicroRNA/ge [Genetics]
+ Computational Biology/sn [Statistics & Numerical Data]
+ Fatty Acids/me [Metabolism]
+ Female
+ Gene Expression Regulation
+ Humans
+ *Lipid Metabolism/ge [Genetics]
+ Male
+ Metabolic Networks and Pathways/ge [Genetics]
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ *Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ Phosphatidylinositol 3-Kinases/bl [Blood]
+ Phosphatidylinositol 3-Kinases/ge [Genetics]
+ Proto-Oncogene Proteins c-akt/bl [Blood]
+ Proto-Oncogene Proteins c-akt/ge [Genetics]
+ Signal Transduction
+Keyword Heading
+ Obesity
+ bioinformatic analyses
+ circulating microRNAs
+ target genes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Context: Differential expression profiles of microRNAs have been reported in human obesity suggesting a miRNAs role in the development of obesity and associated disorders. Objective: To review circulating microRNAs (c-miRNAs) dysregulated in human obesity and to predict their possible target genes. Methods: We performed a systematic review on PubMed database (PROSPERO, CRD42017077742) for original works on c-miRNAs and human obesity and recorded c-miRNAs with differential expression profiles. Potential target genes and metabolic pathways for dysregulated miRNAs with at least two independent reports were searched using bioinformatic tools. Results: Twenty-two c-miRNAs are overexpressed, nine underexpressed and two c-miRNAs dysregulated in both directions in people with obesity compared to lean controls. Bioinformatic analyses suggest these c-miRNAs target on genes associated with fatty acid metabolism and PI3k/Akt pathway. Conclusion: Literature records 33 c-miRNAs confirmedly dysregulated in human obesity. Their predicted target genes are involved in pathways that could explain the development of obesity and its comorbidities. Further research will clarify the role of these miRNAs on metabolic diseases and their usefulness for the prognosis, prevention and treatment of obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Circulating MicroRNA). 0 (Fatty Acids). EC 2-7-11-1 (Proto-Oncogene Proteins c-akt).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f1354750X.2019.1606279
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ortiz-Dosal&issn=1354-750X&title=Biomarkers&atitle=Circulating+microRNAs+in+human+obesity%3A+a+systematic+review.&volume=24&issue=6&spage=499&epage=509&date=2019&doi=10.1080%2F1354750X.2019.1606279&pmid=30990364&sid=OVID:medline
+
+<1705>
+Unique Identifier
+ 30988006
+Title
+ Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates.
+Source
+ Journal of Biological Chemistry. 294(25):9706-9719, 2019 06 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Butler AA; Zhang J; Price CA; Stevens JR; Graham JL; Stanhope KL; King S; Krauss RM; Bremer AA; Havel PJ
+Author NameID
+ Butler, Andrew A; ORCID: https://orcid.org/0000-0001-7196-0170
+ Graham, James L; ORCID: https://orcid.org/0000-0001-6507-8149
+ Stanhope, Kimber L; ORCID: https://orcid.org/0000-0002-2474-0914
+Authors Full Name
+ Butler, Andrew A; Zhang, Jinsong; Price, Candice A; Stevens, Joseph R; Graham, James L; Stanhope, Kimber L; King, Sarah; Krauss, Ronald M; Bremer, Andrew A; Havel, Peter J.
+Institution
+ Butler, Andrew A. From the Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, andrew.butler@health.slu.edu.
+ Butler, Andrew A. The Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, Missouri 63104.
+ Zhang, Jinsong. From the Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104.
+ Zhang, Jinsong. The Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, Missouri 63104.
+ Price, Candice A. the Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, Davis, California 95616.
+ Stevens, Joseph R. From the Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104.
+ Graham, James L. the Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, Davis, California 95616.
+ Stanhope, Kimber L. the Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, Davis, California 95616.
+ King, Sarah. the Children's Hospital Oakland Research Institute, Oakland, California 94609, and.
+ Krauss, Ronald M. the Children's Hospital Oakland Research Institute, Oakland, California 94609, and.
+ Bremer, Andrew A. the Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232.
+ Havel, Peter J. the Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, Davis, California 95616, pjhavel@ucdavis.edu.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Animals
+ Atherosclerosis/bl [Blood]
+ Atherosclerosis/et [Etiology]
+ *Biomarkers/bl [Blood]
+ *Diet/ae [Adverse Effects]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/et [Etiology]
+ Fructose/ad [Administration & Dosage]
+ *Fructose/ae [Adverse Effects]
+ Glucose/ad [Administration & Dosage]
+ *Glucose/ae [Adverse Effects]
+ *Intercellular Signaling Peptides and Proteins/bl [Blood]
+ Intercellular Signaling Peptides and Proteins/me [Metabolism]
+ Macaca mulatta
+ Male
+ Mice, Transgenic
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ Papio
+ *Weight Gain
+Keyword Heading
+ apolipoprotein
+ circadian
+ dyslipidemia
+ epigenetics
+ glucose metabolism
+ insulin resistance
+ leptin
+ nutrition
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin's roles in human metabolism are unclear. In silico expression profiling in a nonhuman primate diurnal transcriptome atlas (GSE98965) revealed a dynamic and diurnal pattern of ENHO expression. ENHO expression is abundant in brain, including ventromedial and lateral hypothalamic nuclei regulating appetite and autonomic function. Lower ENHO expression is present in liver, lung, kidney, ileum, and some endocrine glands. Hepatic ENHO expression associates with genes involved in glucose and lipid metabolism. Unsupervised hierarchical clustering identified 426 genes co-regulated with ENHO in liver, ileum, kidney medulla, and lung. Gene Ontology analysis of this cluster revealed enrichment for epigenetic silencing by histone H3K27 trimethylation and biological processes related to neural function. Dietary intervention experiments with 59 adult male rhesus macaques indicated low plasma adropin concentrations were positively correlated with fasting glucose, plasma leptin, and apolipoprotein C3 (APOC3) concentrations. During consumption of a high-sugar (fructose) diet, which induced 10% weight gain, animals with low adropin had larger increases of plasma leptin and more severe hyperglycemia. Declining adropin concentrations were correlated with increases of plasma APOC3 and triglycerides. In summary, peripheral ENHO expression associates with pathways related to epigenetic and neural functions, and carbohydrate and lipid metabolism, suggesting co-regulation in nonhuman primates. Low circulating adropin predicts increased weight gain and metabolic dysregulation during consumption of a high-sugar diet. Copyright © 2019 Butler et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Enho protein, mouse). 0 (Intercellular Signaling Peptides and Proteins). 30237-26-4 (Fructose). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1074%2fjbc.RA119.007528
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Butler&issn=0021-9258&title=Journal+of+Biological+Chemistry&atitle=Low+plasma+adropin+concentrations+increase+risks+of+weight+gain+and+metabolic+dysregulation+in+response+to+a+high-sugar+diet+in+male+nonhuman+primates.&volume=294&issue=25&spage=9706&epage=9719&date=2019&doi=10.1074%2Fjbc.RA119.007528&pmid=30988006&sid=OVID:medline
+
+<1706>
+Unique Identifier
+ 30986960
+Title
+ Serum Lutein is related to Relational Memory Performance.
+Source
+ Nutrients. 11(4), 2019 Apr 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cannavale CN; Hassevoort KM; Edwards CG; Thompson SV; Burd NA; Holscher HD; Erdman JW Jr; Cohen NJ; Khan NA
+Author NameID
+ Hassevoort, Kelsey M; ORCID: https://orcid.org/0000-0002-9105-3065
+ Burd, Nicholas A; ORCID: https://orcid.org/0000-0001-5581-3154
+ Holscher, Hannah D; ORCID: https://orcid.org/0000-0003-4918-2426
+ Khan, Naiman A; ORCID: https://orcid.org/0000-0002-6135-9389
+Authors Full Name
+ Cannavale, Corinne N; Hassevoort, Kelsey M; Edwards, Caitlyn G; Thompson, Sharon V; Burd, Nicholas A; Holscher, Hannah D; Erdman, John W Jr; Cohen, Neal J; Khan, Naiman A.
+Institution
+ Cannavale, Corinne N. Neuroscience Program, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. cannava2@illinois.edu.
+ Hassevoort, Kelsey M. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. kelseyhassevoort@gmail.com.
+ Hassevoort, Kelsey M. Center for Brain Plasticity, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. kelseyhassevoort@gmail.com.
+ Edwards, Caitlyn G. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. cgedwar2@illinois.edu.
+ Thompson, Sharon V. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. svthomp2@illinois.edu.
+ Burd, Nicholas A. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. naburd@illinois.edu.
+ Burd, Nicholas A. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. naburd@illinois.edu.
+ Holscher, Hannah D. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. hholsche@illinois.edu.
+ Holscher, Hannah D. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. hholsche@illinois.edu.
+ Holscher, Hannah D. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. hholsche@illinois.edu.
+ Erdman, John W Jr. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. jwerdman@illinois.edu.
+ Erdman, John W Jr. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. jwerdman@illinois.edu.
+ Cohen, Neal J. Neuroscience Program, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. njc@illinois.edu.
+ Cohen, Neal J. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. njc@illinois.edu.
+ Cohen, Neal J. Center for Brain Plasticity, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. njc@illinois.edu.
+ Cohen, Neal J. Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. njc@illinois.edu.
+ Khan, Naiman A. Neuroscience Program, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. nakhan2@illinois.edu.
+ Khan, Naiman A. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. nakhan2@illinois.edu.
+ Khan, Naiman A. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. nakhan2@illinois.edu.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Chromatography, High Pressure Liquid
+ Female
+ Hippocampus/pp [Physiopathology]
+ Humans
+ *Lutein/bl [Blood]
+ Macula Lutea/ch [Chemistry]
+ Macular Pigment/an [Analysis]
+ Male
+ Middle Aged
+ Neuropsychological Tests
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/px [Psychology]
+ *Spatial Memory
+ Time Factors
+Keyword Heading
+ carotenoids
+ hippocampus
+ nutrition
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Dietary carotenoids, plant pigments with anti-oxidant properties, accumulate in neural tissue and are often found in lower concentrations among individuals with obesity. Given previous evidence of negative associations between excess adiposity and memory, it is possible that greater carotenoid status may confer neuroprotective effects among persons with overweight or obesity. This study aimed to elucidate relationships between carotenoids assessed in diet, serum, and the macula (macular pigment optical density (MPOD)) and relational memory among adults who are overweight or obese. Adults aged 25-45 years (N = 94) completed a spatial reconstruction task. Task performance was evaluated for accuracy of item placement during reconstruction relative to the location of the item during the study phase. Dietary carotenoids were assessed using 7-day diet records. Serum carotenoids were measured using high-performance liquid chromatography. Hierarchical linear regression analyses were used to determine the relationship between carotenoids and task performance. Although initial correlations indicated that dietary lutein, beta-carotene, and serum beta-carotene were positively associated with memory performance, these relationships were not sustained following adjustment for age, sex, and BMI. Serum lutein remained positively associated with accuracy in object binding and inversely related to misplacement error after controlling for covariates. Macular carotenoids were not related to memory performance. Findings from this study indicate that among the carotenoids evaluated, lutein may play an important role in hippocampal function among adults who are overweight or obese.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Macular Pigment). X72A60C9MT (Lutein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11040768
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cannavale&issn=2072-6643&title=Nutrients&atitle=Serum+Lutein+is+related+to+Relational+Memory+Performance.&volume=11&issue=4&spage=&epage=&date=2019&doi=10.3390%2Fnu11040768&pmid=30986960&sid=OVID:medline
+
+<1707>
+Unique Identifier
+ 30984547
+Title
+ Proteomic pattern of breast milk discriminates obese mothers with infants of delayed weight gain from normal-weight mothers with infants of normal weight gain.
+Source
+ FEBS Open Bio. 9(4):736-742, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Atanassov C; Viallemonteil E; Lucas C; Perivier M; Claverol S; Raimond R; Hankard R
+Author NameID
+ Atanassov, Christo; ORCID: https://orcid.org/0000-0002-6525-5720
+Authors Full Name
+ Atanassov, Christo; Viallemonteil, Etienne; Lucas, Charlotte; Perivier, Marylise; Claverol, Stephane; Raimond, Roland; Hankard, Regis.
+Institution
+ Atanassov, Christo. CHU - La Miletrie Poitiers France.
+ Atanassov, Christo. UMR-CNRS 7267 Universite de Potiers France.
+ Viallemonteil, Etienne. UMR-CNRS 7267 Universite de Potiers France.
+ Lucas, Charlotte. Pediatrie Multidisciplinaire-Nutrition de l'Enfant CHU - La Miletrie Poitiers France.
+ Lucas, Charlotte. INSERM CIC 1402 Poitiers France.
+ Perivier, Marylise. CHU - La Miletrie Poitiers France.
+ Claverol, Stephane. Pole Proteomique Universite Victor Segalen - Bordeaux 2 France.
+ Raimond, Roland. UMR-CNRS 7267 Universite de Potiers France.
+ Hankard, Regis. INSERM U1069 Universite Francois Rabelais Tours France.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ *Child Development/ph [Physiology]
+ Humans
+ Infant, Newborn
+ *Milk Proteins/an [Analysis]
+ Milk, Human
+ Mothers
+ *Obesity/me [Metabolism]
+ *Proteome/an [Analysis]
+ *Weight Gain/ph [Physiology]
+Keyword Heading
+ SELDI biomarker
+ breast milk
+ infant weight gain
+ maternal obesity
+ pIgR
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We previously reported that exclusively breastfed infants born to mothers with pregestational obesity gain less weight during the first month after birth than those born to mothers of normal pregestational weight. This issue is potentially important since lower weight gain in breastfed infants of obese mothers might increase the risk of developing later obesity. Breast milk quality and quantity, together with breastfeeding practice, possibly influence infants' feeding behavior, appetite control, and regulation of growth later in life. The issue of whether breast milk protein patterns from obese mothers differ in composition from those of non-obese mothers remains largely unexplored. Here, we established a breast milk proteomic pattern that discriminates obese mothers and infants with delayed weight gain at 1 month after birth from normal-weight mothers with infants of the same age and with normal weight gain. Obese mothers were matched to normal-weight mothers (n = 26; body mass index 33.5 +/- 3.2 vs 21.5 +/- 1.5 kg.m-2). The mean weight gain of infants in the obese group at 1 month after birth was 430.8 g lower than that of the infants in the control group. Analysis of the breast milk delipidized fraction by surface-enhanced laser desorption/ionization on CM10 and Q10 arrays was followed by MS-assisted purification and LC-MS/MS microsequencing of a selected biomarker. We identified 15 candidate protein biomarkers, seven of which were overexpressed in the obese group and eight in the normal-weight group. One of the most significant candidate biomarkers, overexpressed in the obese group, was identified as a fragment of the sixth extracellular domain of the polymeric immunoglobulin receptor. Further structural identification of these candidate biomarkers and their validation in clinical assays may facilitate the development of a predictive immunoassay.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Milk Proteins). 0 (Proteome).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2f2211-5463.12610
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Atanassov&issn=2211-5463&title=FEBS+Open+Bio&atitle=Proteomic+pattern+of+breast+milk+discriminates+obese+mothers+with+infants+of+delayed+weight+gain+from+normal-weight+mothers+with+infants+of+normal+weight+gain.&volume=9&issue=4&spage=736&epage=742&date=2019&doi=10.1002%2F2211-5463.12610&pmid=30984547&sid=OVID:medline
+
+<1708>
+Unique Identifier
+ 30983372
+Title
+ [Association of rs3751812 polymorphism of the FTO gene with adiposity and metabolic markers in Chilean population. Results of the GENADIO study]. [Spanish]
+Original Title
+ Asociacion del polimorfismo rs3751812 del gen FTO con marcadores de adiposidad y metabolicos en poblacion chilena. Resultados del estudio GENADIO.
+Source
+ Nutricion Hospitalaria. 36(3):589-598, 2019 Jul 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mardones L; Petermann-Rocha F; Martinez-Sanguinetti MA; Leiva AM; Troncoso Pantoja CA; Martorell M; Ulloa N; Lasserre Laso NF; Perez-Bravo F; Celis-Morales C; Villagran M
+Authors Full Name
+ Mardones, Lorena; Petermann-Rocha, Fanny; Martinez-Sanguinetti, Maria Adela; Leiva, Ana Maria; Troncoso Pantoja, Claudia Andrea; Martorell, Miquel; Ulloa, Natalia; Lasserre Laso, Nicole Francisca; Perez-Bravo, Francisco; Celis-Morales, Carlos; Villagran, Marcelo.
+Institution
+ Mardones, Lorena. Universidad Catolica de la Santisima Concepcion.
+ Petermann-Rocha, Fanny. Institute of Cardiovascular and Medical Sciences. University of Glasgow.
+ Martinez-Sanguinetti, Maria Adela. Facultad de Ciencias. Universidad Austral de Chile.
+ Leiva, Ana Maria. Instituto de Anatomia, Histologia y Patologia. Facultad de Medicina. Universidad Austral de Chile.
+ Troncoso Pantoja, Claudia Andrea. Universidad Catolica de la Santisima Concepcion.
+ Martorell, Miquel. Facultad de Farmacia. Universidad de Concepcion.
+ Ulloa, Natalia. Universidad de Concepcion. Concepcion.
+ Lasserre Laso, Nicole Francisca. Universidad Santo Tomas.
+ Perez-Bravo, Francisco. Instituto de Nutricion y Tecnologia de los alimentos (INTA).
+ Celis-Morales, Carlos. Centro de Investigacion en Fisiologia del Ejercicio - CIFE. Universidad Mayor.
+ Villagran, Marcelo. Universidad Catolica de la Santisima Concepcion.
+MeSH Subject Headings
+ *Adiposity/ge [Genetics]
+ Adult
+ *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/ge [Genetics]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Body Weight
+ Chile/ep [Epidemiology]
+ Female
+ Gene Frequency
+ Humans
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Polymorphism, Genetic
+ Socioeconomic Factors
+ Waist Circumference/ge [Genetics]
+ Young Adult
+Keyword Heading
+ Obesidad. Diabetes mellitus tipo 2. FTO. rs3751812. Genetica.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Background: genetic variants of the FTO gene confer the highest risk of obesity identified so far. Associations between the FTO gene and alterations in metabolic markers have been reported in different populations but not in Chileans. The aim of this study was therefore to investigate the association of rs3751812 gene polymorphism with adiposity and metabolic markers in the Chilean adult population. Methods: genotype of the FTO gene was determined in 409 participants from the GENADIO study. Adiposity markers (body weight, BMI, % fat mass and waist circumference), metabolic markers (glycemia, insulin, HOMAIR, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, leptin, ALT, GGT, PCRhs) and blood pressure were measured. The association between the FTO genotype and the different markers was determined using linear regression analyses. Results: there was an association between the polymorphism and all adiposity markers as well as insulin, HOMAIR, leptin and HDL cholesterol (p < 0.05) in the fully adjusted model. For total cholesterol, triglycerides, LDL cholesterol, ALT, GGT and PCRhs, the association disappeared after adjustment by body mass index. Conclusion : our findings verify the association between the FTO rs3751812 polymorphism with obesity, hyperinsulinemia, hyperleptinemia and lower levels of HDL cholesterol in the Chilean population. These alterations could increase the risk of diabetes mellitus type II and metabolic syndrome.
+Other Abstract
+ Publisher
+ INTRODUCCION: Antecedentes: el gen FTO presenta las variantes geneticas que confieren el mayor riesgo de obesidad hasta ahora identificado. Se han reportado asociaciones de polimorfismos del gen FTO y alteraciones de marcadores metabolicos en diversas poblaciones, pero no en chilenos. El objetivo de este estudio fue investigar la asociacion del polimorfismo rs3751812 con marcadores de adiposidad y metabolicos en adultos chilenos. Metodos: se determino el genotipo del FTO en 409 participantes del estudio GENADIO. Se evaluaron marcadores de adiposidad (peso corporal, indice de masa corporal [IMC], % de masa grasa y perimetro de cintura), marcadores metabolicos (glicemia, insulina, HOMAIR, colesterol total, colesterol LDL, colesterol HDL, trigliceridos, leptina, ALT, GGT, PCRus) y presion arterial. La asociacion entre el genotipo FTO y los distintos marcadores se realizo mediante analisis de regresion lineal. Resultados: tras ajustar los marcadores por las variables de confusion, se evidencio una asociacion significativa de los genotipos de riesgo con todos los marcadores de adiposidad estudiados y con los marcadores metabolicos: insulina, HOMAIR, leptina y colesterol HDL (p < 0,05). Para colesterol total, trigliceridos, colesterol LDL, ALT, GGT y PCRus, la asociacion perdio significancia al ajustar por IMC. Conclusion: este estudio revela que existe una asociacion entre el polimorfismo rs3751812 del gen FTO con obesidad, hiperinsulinemia, hiperleptinemia y bajos niveles de colesterol HDL en la poblacion chilena, lo que podria aumentar el riesgo de desarrollar diabetes mellitus tipo II y sindrome metabolico.
+ Language: Spanish
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 1-14-11-33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO). EC 1-14-11-33 (FTO protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.20960%2fnh.2275
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mardones&issn=0212-1611&title=Nutricion+Hospitalaria&atitle=Asociacion+del+polimorfismo+rs3751812+del+gen+FTO+con+marcadores+de+adiposidad+y+metabolicos+en+poblacion+chilena.+Resultados+del+estudio+GENADIO.&volume=36&issue=3&spage=589&epage=598&date=2019&doi=10.20960%2Fnh.2275&pmid=30983372&sid=OVID:medline
+
+<1709>
+Unique Identifier
+ 30981648
+Title
+ Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course.
+Source
+ EBioMedicine. 43:392-410, 2019 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Castro K; Ntranos A; Amatruda M; Petracca M; Kosa P; Chen EY; Morstein J; Trauner D; Watson CT; Kiebish MA; Bielekova B; Inglese M; Katz Sand I; Casaccia P
+Authors Full Name
+ Castro, Kamilah; Ntranos, Achilles; Amatruda, Mario; Petracca, Maria; Kosa, Peter; Chen, Emily Y; Morstein, Johannes; Trauner, Dirk; Watson, Corey T; Kiebish, Michael A; Bielekova, Bibiana; Inglese, Matilde; Katz Sand, Ilana; Casaccia, Patrizia.
+Institution
+ Castro, Kamilah. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NY, New York, United States of America.
+ Ntranos, Achilles. Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, United States of America.
+ Amatruda, Mario. Advanced Science Research Center at The Graduate Center of The City University of New York and Inter-Institutional Center for Glial Biology at Icahn School of Medicine New York, New York, United States of America.
+ Petracca, Maria. Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, United States of America.
+ Kosa, Peter. Neuroimmunological Disease Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
+ Chen, Emily Y. BERG, LLC. Framingham, MA, United States of America.
+ Morstein, Johannes. Department of Chemistry, New York University, NY, New York, United States of America.
+ Trauner, Dirk. Department of Chemistry, New York University, NY, New York, United States of America.
+ Watson, Corey T. Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, United States of America.
+ Kiebish, Michael A. BERG, LLC. Framingham, MA, United States of America.
+ Bielekova, Bibiana. Neuroimmunological Disease Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
+ Inglese, Matilde. Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, United States of America.
+ Katz Sand, Ilana. Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, United States of America.
+ Casaccia, Patrizia. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NY, New York, United States of America; Advanced Science Research Center at The Graduate Center of The City University of New York and Inter-Institutional Center for Glial Biology at Icahn School of Medicine New York, New York, United States of America. Electronic address: patrizia.casaccia@asrc.cuny.edu.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Body Mass Index
+ Brain/pa [Pathology]
+ *Ceramides/me [Metabolism]
+ Ceramides/pd [Pharmacology]
+ DNA Methylation/de [Drug Effects]
+ *DNA Methylation
+ Disease Models, Animal
+ Disease Progression
+ Disease Susceptibility
+ Epigenesis, Genetic
+ Epigenomics/mt [Methods]
+ Female
+ Humans
+ Leukocyte Count
+ Lipid Metabolism/de [Drug Effects]
+ Lipids/bl [Blood]
+ Male
+ Metabolome
+ Metabolomics/mt [Methods]
+ Mice
+ Monocytes/de [Drug Effects]
+ Monocytes/im [Immunology]
+ Monocytes/me [Metabolism]
+ Multiple Sclerosis/dg [Diagnostic Imaging]
+ *Multiple Sclerosis/et [Etiology]
+ *Multiple Sclerosis/me [Metabolism]
+ Multiple Sclerosis/pa [Pathology]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Organ Size
+ Transcription, Genetic
+Keyword Heading
+ Epigenetics
+ Immunity
+ Lipids
+ Neurodegeneration
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS.
+
+ METHODS: Fifty-four therapy-naive Relapsing Remitting (RR) MS patients with high and normal BMI received clinical and MRI evaluation. Blood samples were immunophenotyped, and processed for unbiased plasma lipidomic profiling and genome-wide DNA methylation analysis of circulating monocytes. The main findings at baseline were validated in an independent cohort of 91 therapy-naive RRMS patients. Disease course was evaluated by a two-year longitudinal follow up and mechanistic hypotheses tested in human cell cultures and in animal models of MS.
+
+ FINDINGS: Higher monocytic counts and plasma ceramides, and hypermethylation of genes involved in negative regulation of cell proliferation were detected in the high BMI group of MS patients compared to normal BMI. Ceramide treatment of monocytic cell cultures increased proliferation in a dose-dependent manner and was prevented by DNA methylation inhibitors. The high BMI group of MS patients showed a negative correlation between monocytic counts and brain volume. Those subjects at a two-year follow-up showed increased T1 lesion load, increased disease activity, and worsened clinical disability. Lastly, the relationship between body weight, monocytic infiltration, DNA methylation and disease course was validated in mouse models of MS.
+
+ INTERPRETATION: High BMI negatively impacts disease course in Multiple Sclerosis by modulating monocyte cell number through ceramide-induced DNA methylation of anti-proliferative genes. FUND: This work was supported by funds from the Friedman Brain Institute, NIH, and Multiple Sclerosis Society. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ceramides). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ebiom.2019.03.087
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Castro&issn=2352-3964&title=EBioMedicine&atitle=Body+Mass+Index+in+Multiple+Sclerosis+modulates+ceramide-induced+DNA+methylation+and+disease+course.&volume=43&issue=&spage=392&epage=410&date=2019&doi=10.1016%2Fj.ebiom.2019.03.087&pmid=30981648&sid=OVID:medline
+
+<1710>
+Unique Identifier
+ 30968683
+Title
+ Megalin - a facultative marker of obesity-related glomerulopathy in children.
+Source
+ Journal of Biological Regulators & Homeostatic Agents. 33(2):415-420, 2019 Mar-Apr,.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ostalska-Nowicka D; Mackowiak-Lewandowicz K; Perek B; Zaorska K; Zachwieja J; Nowicki M
+Authors Full Name
+ Ostalska-Nowicka, D; Mackowiak-Lewandowicz, K; Perek, B; Zaorska, K; Zachwieja, J; Nowicki, M.
+Institution
+ Ostalska-Nowicka, D. Department of Pediatric Cardiology, Nephrology and Hypertension, Poznan University of Medical Sciences, Poznan, Poland.
+ Mackowiak-Lewandowicz, K. Department of Pediatric Cardiology, Nephrology and Hypertension, Poznan University of Medical Sciences, Poznan, Poland.
+ Perek, B. Department of Cardiac Surgery, Poznan University of Medical Sciences, Poznan, Poland.
+ Zaorska, K. Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland.
+ Zachwieja, J. Department of Pediatric Cardiology, Nephrology and Hypertension, Poznan University of Medical Sciences, Poznan, Poland.
+ Nowicki, M. Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Child
+ *Glomerulonephritis/pa [Pathology]
+ Humans
+ *Kidney Tubules, Proximal/pa [Pathology]
+ *Low Density Lipoprotein Receptor-Related Protein-2/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+Keyword Heading
+ BMI
+ NGAL
+ a Body Shape Index
+ children
+ megalin
+ obesity
+ obesity-related glomerulopathy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity-related glomerulopathy (ORG) is an increasingly detected syndrome present in children with obesity. Megalin, a constitutive proximal tubule cell protein, when present in urine, can be considered as a biomarker indicating renal injury in these children.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Low Density Lipoprotein Receptor-Related Protein-2).
+Publication Type
+ Letter.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&AN=30968683
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ostalska-Nowicka&issn=0393-974X&title=Journal+of+Biological+Regulators+%26+Homeostatic+Agents&atitle=Megalin+-+a+facultative+marker+of+obesity-related+glomerulopathy+in+children.&volume=33&issue=2&spage=415&epage=420&date=2019&doi=&pmid=30968683&sid=OVID:medline
+
+<1711>
+Unique Identifier
+ 30968321
+Title
+ Cardiovascular disease risk factors are elevated among a cohort of young sexual and gender minorities in Chicago.
+Source
+ Journal of Behavioral Medicine. 42(6):1073-1081, 2019 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Morgan E; D'Aquila R; Carnethon MR; Mustanski B
+Author NameID
+ Morgan, Ethan; ORCID: http://orcid.org/0000-0001-7189-680X
+Authors Full Name
+ Morgan, Ethan; D'Aquila, Richard; Carnethon, Mercedes R; Mustanski, Brian.
+Institution
+ Morgan, Ethan. Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, 625 N Michigan Ave, Suite 14-061, Chicago, IL, 60611, USA.
+ D'Aquila, Richard. Department of Medicine, Division of Infectious Diseases and HIV Translational Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
+ Carnethon, Mercedes R. Department of Preventative Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
+ Mustanski, Brian. Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, 625 N Michigan Ave, Suite 14-061, Chicago, IL, 60611, USA. brian@northwestern.edu.
+ Mustanski, Brian. Department of Medical Social Sciences, Northwestern University, Chicago, IL, USA. brian@northwestern.edu.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases/et [Etiology]
+ Chicago
+ Cohort Studies
+ Female
+ Humans
+ Male
+ *Marijuana Smoking/ae [Adverse Effects]
+ *Obesity/co [Complications]
+ Risk Factors
+ *Sexual and Gender Minorities
+ Young Adult
+Keyword Heading
+ Cardiovascular disease
+ HIV
+ Inflammation
+ MSM
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ To date, little research has examined cardiovascular (CVD) risk among young sexual and gender minorities, a population which behavioral research has suggested may be at unique risk of poor CVD outcomes. We assessed behavioral risk factors and biomarkers of CVD risk among young sexual and gender minorities (YSGM) aged 16-29 in Chicago who are participants in the RADAR cohort (analytic N = 936). Multiplex cytokine and inflammatory biomarker assays were run on plasma from all HIV+ participants and demographically-matched HIV- participants (n = 237). Geographic data were used to assess mean C-reactive protein (CRP) level per community area of residence in Chicago. YSGM in this cohort exhibited lower rates of obesity (19.2% in RADAR vs. 35.7% in earlier studies of heterosexual youth) and comparable rates of past 30-day tobacco use (37.9 vs. 38.1%). Conversely, higher rates were observed among several other risk factors including C-reactive protein (mean = 6.9 mg/L vs. 2.1 mg/L), marijuana use (72.5 vs. 45.3%), perceived stress (mean = 15.5 vs. 14.2), and HIV (20.0 vs. < 1% nationally). Finally, we observed geographic heterogeneity in mean CRP values by community area across the Chicago region with the highest and lowest values both found in neighborhoods on the North side of the city. In sum, these analyses demonstrate that YSGM may be at increased risk of CVD beginning from an early age. Future research should assess whether sexual minority-related stressors increase long-term CVD risk and should also longitudinally study the role of multiple risk factors on CVD morbidity and mortality among YSGM.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs10865-019-00038-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Morgan&issn=0160-7715&title=Journal+of+Behavioral+Medicine&atitle=Cardiovascular+disease+risk+factors+are+elevated+among+a+cohort+of+young+sexual+and+gender+minorities+in+Chicago.&volume=42&issue=6&spage=1073&epage=1081&date=2019&doi=10.1007%2Fs10865-019-00038-z&pmid=30968321&sid=OVID:medline
+
+<1712>
+Unique Identifier
+ 30967146
+Title
+ Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults.
+Source
+ Lipids in Health & Disease. 18(1):94, 2019 Apr 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bagheri M; Djazayery A; Farzadfar F; Qi L; Yekaninejad MS; Aslibekyan S; Chamari M; Hassani H; Koletzko B; Uhl O
+Author NameID
+ Bagheri, Minoo; ORCID: http://orcid.org/0000-0002-6093-613X
+Authors Full Name
+ Bagheri, Minoo; Djazayery, Abolghasem; Farzadfar, Farshad; Qi, Lu; Yekaninejad, Mir Saeed; Aslibekyan, Stella; Chamari, Maryam; Hassani, Hossein; Koletzko, Berthold; Uhl, Olaf.
+Institution
+ Bagheri, Minoo. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No 44, Hojjat-dost Alley, Naderi St., Keshavarz Blvd, Tehran, 1416-643931, Iran. bagheriminoo@yahoo.com.
+ Djazayery, Abolghasem. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No 44, Hojjat-dost Alley, Naderi St., Keshavarz Blvd, Tehran, 1416-643931, Iran.
+ Farzadfar, Farshad. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
+ Qi, Lu. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
+ Yekaninejad, Mir Saeed. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
+ Aslibekyan, Stella. Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Chamari, Maryam. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No 44, Hojjat-dost Alley, Naderi St., Keshavarz Blvd, Tehran, 1416-643931, Iran.
+ Hassani, Hossein. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No 44, Hojjat-dost Alley, Naderi St., Keshavarz Blvd, Tehran, 1416-643931, Iran.
+ Koletzko, Berthold. Division of Metabolic and Nutritional Medicine, Ludwig-Maximilians-Universitat Munchen, Dr. von Hauner Children's Hospital, 80337, Munich, Germany.
+ Uhl, Olaf. Division of Metabolic and Nutritional Medicine, Ludwig-Maximilians-Universitat Munchen, Dr. von Hauner Children's Hospital, 80337, Munich, Germany.
+MeSH Subject Headings
+ Adult
+ Alcohol Drinking/pp [Physiopathology]
+ *Amino Acids/bl [Blood]
+ Amino Acids/cl [Classification]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Carnitine/aa [Analogs & Derivatives]
+ Carnitine/bl [Blood]
+ Case-Control Studies
+ Chromatography, Liquid
+ Exercise
+ Female
+ Humans
+ Iran
+ Linear Models
+ *Lysophospholipids/bl [Blood]
+ Lysophospholipids/cl [Classification]
+ Male
+ Metabolome
+ Metabolomics/mt [Methods]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Phosphatidylcholines/bl [Blood]
+ Phosphatidylcholines/cl [Classification]
+ Smoking/pp [Physiopathology]
+ *Sphingomyelins/bl [Blood]
+ Sphingomyelins/cl [Classification]
+ Tandem Mass Spectrometry
+Keyword Heading
+ Amino acids
+ Metabolomics
+ Obesity
+ Polar lipids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity, widely recognized as a serious health concern, is characterized by profoundly altered metabolism. However, the intermediate metabolites involved in this change remain largely unknown.
+
+ OBJECTIVE: We conducted targeted metabolomics profiling to identify moieties associated with adult obesity.
+
+ METHODS: In this case-control study of Iranian adults, 200 obese patients were compared with 100 controls based on 104 metabolites profiled by a targeted metabolomic approach using liquid chromatography coupled to triple quadrupole mass spectrometry (LC-MS/MS). The analysis comprised acylcarnitines, diacyl-phosphatidylcholines (PCaa), acyl-alkyl-phosphatidylcholines (PCae), sphingomyelins (SM), lyso-phospholipids (LPC) and amino acids. We performed multivariable linear regression to identify metabolites associated with obesity, adjusting for age, sex, total energy intake, total physical activity, smoking, and alcohol consumption. The Bonferroni correction was used to adjust for multiple testing.
+
+ RESULTS: A pattern of 19 metabolites was significantly associated with obesity. Branched chain amino acids, alanine, glutamic acid, proline, tyrosine LPCa C16:1, PCaa C32:1, PCaa C32:2 and PCaa C38:3 were positively, while serine, asparagine, LPCa C18:1, LPCa C18:2, LPCe C18:0, PCae C34:3, PCae C38:4 and PCae C40:6 were negatively associated with obesity (all p < 0.00048).
+
+ CONCLUSIONS: A metabolomic profile containing 9 amino acids and 10 polar lipids may serve as a potential biomarker of adult obesity. Further studies are warranted to replicate these findings as well as investigate potential changes in this profile after weight reduction.
+Registry Number/Name of Substance
+ 0 (Amino Acids). 0 (Biomarkers). 0 (Lysophospholipids). 0 (Phosphatidylcholines). 0 (Sphingomyelins). 0 (acylcarnitine). S7UI8SM58A (Carnitine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12944-019-1037-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bagheri&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Plasma+metabolomic+profiling+of+amino+acids+and+polar+lipids+in+Iranian+obese+adults.&volume=18&issue=1&spage=94&epage=&date=2019&doi=10.1186%2Fs12944-019-1037-0&pmid=30967146&sid=OVID:medline
+
+<1713>
+Unique Identifier
+ 30950443
+Title
+ Oxidative stress in relation to obesity in breast cancer.
+Source
+ Indian Journal of Cancer. 56(1):41-44, 2019 Jan-Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sateesh R; Rao Bitla AR; Budugu SR; Mutheeswariah Y; Narendra H; Phaneedra BV; Lakshmi AY
+Authors Full Name
+ Sateesh, R; Rao Bitla, Aparna Rajeshwar; Budugu, Sandya Rani; Mutheeswariah, Y; Narendra, H; Phaneedra, B V; Lakshmi, A Y.
+Institution
+ Sateesh, R. Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
+ Rao Bitla, Aparna Rajeshwar. Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
+ Budugu, Sandya Rani. Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
+ Mutheeswariah, Y. Department of Surgery, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
+ Narendra, H. Department of Surgical Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
+ Phaneedra, B V. Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
+ Lakshmi, A Y. Department of Radiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ *Breast Neoplasms/ep [Epidemiology]
+ *Breast Neoplasms/pa [Pathology]
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ Humans
+ India/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ *Oxidative Stress
+ Prognosis
+Keyword Heading
+ Advanced oxidation protein products
+ breast cancer
+ malondialdehyde
+ obesity
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Breast carcinoma is one of the most common neoplasms in women and is a leading cause of cancer-related deaths worldwide. Obesity-induced chronic inflammation promoted by adipose tissue dysfunction is a key feature, which is thought to be an important link between obesity and cancer. Oxidative stress (OS) has been suggested to play an important role in carcinogenesis. Obese women have been shown to have higher levels of OS markers. The study was performed to know the influence of obesity on OS to be replaced with OS markers in patients with breast cancer.
+
+ MATERIALS AND METHODS: Thirty women attending the outpatient Department of Surgical Oncology and Surgery at Sri Venkateswara Institute of Medical Science, Tirupati, who were clinically diagnosed and histologically confirmed with breast cancer were considered as the patients and 30 healthy women were included as controls. Malondialdehyde (MDA), protein carbonyls (PCC), and advanced oxidation protein products (AOPP) as oxidative markers along with protein thiols and ferric-reducing ability of plasma (FRAP) were studied as markers of antioxidant status.
+
+ RESULTS: Patients with breast cancer had significantly higher levels of MDA (P = 0.005), PCC, and AOPP compared to controls (P = 0.001) and significantly lower levels of thiols and FRAP compared to controls (P = 0.001). No significant correlation was found between OS markers and indices of obesity. A significant association was found between OS markers (P = 0.005), PCC (P = 0.002), AOPP (P = 0.002), and breast cancer.
+
+ CONCLUSIONS: Patients with breast cancer have increased OS as evidenced by an increase in oxidant markers and a decrease in antioxidant markers. OS is not related to their adiposity but is related to the presence of breast cancer.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.4103%2fijc.IJC_247_18
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sateesh&issn=0019-509X&title=Indian+Journal+of+Cancer&atitle=Oxidative+stress+in+relation+to+obesity+in+breast+cancer.&volume=56&issue=1&spage=41&epage=44&date=2019&doi=10.4103%2Fijc.IJC_247_18&pmid=30950443&sid=OVID:medline
+
+<1714>
+Unique Identifier
+ 30948354
+Title
+ Down-regulation of MicroRNA-592 in obesity contributes to hyperglycemia and insulin resistance.
+Source
+ EBioMedicine. 42:494-503, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Song Y; Wu L; Li M; Xiong X; Fang Z; Zhou J; Yan G; Chen X; Yang J; Li Y
+Authors Full Name
+ Song, Yuping; Wu, Ling; Li, Menghui; Xiong, Xuelian; Fang, Zhenfu; Zhou, Jing; Yan, Guofeng; Chen, Xuejin; Yang, Jialin; Li, Yao.
+Institution
+ Song, Yuping. Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai, China.
+ Wu, Ling. Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Li, Menghui. Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
+ Xiong, Xuelian. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan Institute of Metabolic Diseases, Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Fudan University, Shanghai, China.
+ Fang, Zhenfu. Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Zhou, Jing. Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Yan, Guofeng. Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Chen, Xuejin. Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Yang, Jialin. Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai, China. Electronic address: jialinyang2015@126.coms.
+ Li, Yao. Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yaoli_sh@126.com.
+MeSH Subject Headings
+ 3' Untranslated Regions
+ Animals
+ Biomarkers
+ Disease Models, Animal
+ Forkhead Box Protein O1/ge [Genetics]
+ Gene Expression Regulation
+ Glucose/me [Metabolism]
+ Hepatocytes/me [Metabolism]
+ *Hyperglycemia/bl [Blood]
+ *Hyperglycemia/ge [Genetics]
+ *Insulin Resistance/ge [Genetics]
+ Lipid Metabolism
+ Mice
+ *MicroRNAs/ge [Genetics]
+ Obesity/bl [Blood]
+ *Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ RNA, Small Interfering/ge [Genetics]
+Keyword Heading
+ FOXO1
+ Gluconeogenesis
+ Insulin resistance
+ Liver steatosis
+ MicroRNAs
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Many studies have demonstrated that microRNAs, a class of small and non-coding RNA molecules, play an important role in the regulation of glucose and lipid homeostasis. In the present study, we sought to investigate the function of miR-592 in the development of obesity-associated metabolic disorders, including hyperglycemia andinsulin resistance.
+
+ METHODS: The expression levels of miR-592 were measured in the liver of obese mice and humans by quantitative reverse transcription PCR. Loss- and gain-of function experiments were employed to explore the metabolic function of miR-592 using locked nucleic acids and adenovirus in lean and obese mice, respectively. The molecular target of miR-592 was determined by western blotting and luciferase reporter assays.
+
+ FINDINGS: We found a significant decreased expression of miR-592 in the liver of obese mice and humans. Inhibition of miR-592 led to elevated blood glucose levels, enhanced gluconeogenesis and reduced insulin sensitivity in lean mice. In contrast, adenovirus-mediated overexpression of hepatic miR-592 improved metabolic disorders in obese mice. Mechanistically, we found that the transcription factor forkhead box O1 (FOXO1) is a direct target gene of miR-592 to mediate its metabolic functions. miR-592 was able to inhibit the mRNA and protein expression of FOXO1 by binding to its 3'-untranslated region.
+
+ INTERPRETATIONS: Our findings demonstrate that obesity-associated down-regulation of miR-592 plays an important role in the progression of metabolic diseases. Restoration of hepatic miR-592 could improve glucose and lipid metabolism in obese mice. FUND: This work is supported by the National Key Research and Development Program of China (No. 2016YFC1304805 to Dr. Chen), Natural Science Foundation of China (No. 81771574 to Dr. Wu), Shanghai Science Foundation (No. 18ZR1437800 to Dr. Li), Science and Technology Commission of Shanghai Municipality (Nos.18dz2304400 and 15,411,970,700 to Dr. Yang). Copyright © 2019. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (3' Untranslated Regions). 0 (Biomarkers). 0 (Forkhead Box Protein O1). 0 (Foxo1 protein, mouse). 0 (MIRN592 microRNA, mouse). 0 (MicroRNAs). 0 (RNA, Small Interfering). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ebiom.2019.03.041
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Song&issn=2352-3964&title=EBioMedicine&atitle=Down-regulation+of+MicroRNA-592+in+obesity+contributes+to+hyperglycemia+and+insulin+resistance.&volume=42&issue=&spage=494&epage=503&date=2019&doi=10.1016%2Fj.ebiom.2019.03.041&pmid=30948354&sid=OVID:medline
+
+<1715>
+Unique Identifier
+ 30948306
+Title
+ Increased fiber intake predicts the decrease in 2nd phase glucose-induced hyperinsulinemia following a hypocaloric diet in obese subjects.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 29(5):504-512, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Provost V; Lamantia V; Bissonnette S; Cyr Y; Faraj M
+Authors Full Name
+ Provost, V; Lamantia, V; Bissonnette, S; Cyr, Y; Faraj, M.
+Institution
+ Provost, V. Institut de Recherches Cliniques de Montreal (IRCM) and Universite de Montreal, Montreal, Quebec, Canada.
+ Lamantia, V. Institut de Recherches Cliniques de Montreal (IRCM) and Universite de Montreal, Montreal, Quebec, Canada.
+ Bissonnette, S. Institut de Recherches Cliniques de Montreal (IRCM) and Universite de Montreal, Montreal, Quebec, Canada.
+ Cyr, Y. Institut de Recherches Cliniques de Montreal (IRCM) and Universite de Montreal, Montreal, Quebec, Canada.
+ Faraj, M. Institut de Recherches Cliniques de Montreal (IRCM) and Universite de Montreal, Montreal, Quebec, Canada. Electronic address: may.faraj@umontreal.ca.
+MeSH Subject Headings
+ Adiposity
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Caloric Restriction/ae [Adverse Effects]
+ *Caloric Restriction
+ *Dietary Fiber/ad [Administration & Dosage]
+ Female
+ Humans
+ Hyperinsulinism/bl [Blood]
+ Hyperinsulinism/di [Diagnosis]
+ Hyperinsulinism/et [Etiology]
+ *Hyperinsulinism/pc [Prevention & Control]
+ *Insulin/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Time Factors
+ Treatment Outcome
+ Weight Loss
+Keyword Heading
+ Dietary fiber
+ Hypocaloric diet
+ Insulin resistance
+ Insulin secretion
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Higher fiber intake is associated with increased insulin sensitivity (IS) and reduced glucose-induced insulin secretion (GIIS) during isocaloric-diets; however, its role in hypocaloric-diets is unclear. We examined whether increased fiber intake predicts the amelioration in IS and GIIS following a hypocaloric-diet.
+
+ METHODS AND RESULTS: This is a post-hoc analysis of 55 adult subjects (BMI > 27 kg/m2) who completed a 6-month hypocaloric-diet (-500 kcal/day). Dietary intake was assessed using 3-day food records at baseline and post-intervention. We evaluated glucose-induced insulin and C-peptide secretions as AUC of plasma insulin and C-peptide during intravenous-glucose-tolerance tests (IVGTT) and IS via hyperinsulinemic-euglycemic clamps. Data analysis employed regression models and 2-way RM ANOVAs. Post-intervention % change in fiber intake was associated positively with ISclamp (r = 0.30) and negatively with % change in total (r = -0.37) and 2nd phase GIISIVGTT (r = -0.44) but not C-peptide secretion. It remained associated with lower 2nd phase GIISIVGTT after adjustment for sex and % changes in BMI and energy-intake, independently of other macronutrients. Subjects who increased fiber intake (to 28.7 +/- 9.0 g/day) had a greater decrease in 2nd phase GIISIVGTT, not C-peptide secretion, independently of sex or changes in adiposity or energy-intake compared to subjects who decreased intake (to 20.0 +/- 6.8 g/day).
+
+ CONCLUSION: Higher fiber intake is an independent predictor of reduced 2nd phase glucose-induced hyperinsulinemia after a hypocaloric-diet. It was not associated with plasma C-peptide, suggesting a role in faster insulin clearance rather reduced insulin secretion. Promoting high-fiber intake may increase the effectiveness of hypocaloric-diets in preventing type 2 diabetes.
+
+ REGISTRATION: ISRCTN14476404, BioMedCentral.com.
+
+ CLINICAL TRIAL REGISTRATION: This trial was registered at BioMed Central as ISRCTN14476404, on July 28th, 2017. Copyright © 2019. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Fiber). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.numecd.2019.01.014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Provost&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Increased+fiber+intake+predicts+the+decrease+in+2nd+phase+glucose-induced+hyperinsulinemia+following+a+hypocaloric+diet+in+obese+subjects.&volume=29&issue=5&spage=504&epage=512&date=2019&doi=10.1016%2Fj.numecd.2019.01.014&pmid=30948306&sid=OVID:medline
+
+<1716>
+Unique Identifier
+ 30945111
+Title
+ Serum IGF-binding protein 2 (IGFBP-2) concentrations change early after gastric bypass bariatric surgery revealing a possible marker of leptin sensitivity in obese subjects.
+Source
+ Endocrine. 65(1):86-93, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ceccarini G; Pelosini C; Ferrari F; Magno S; Vitti J; Salvetti G; Moretto C; Marioni A; Buccianti P; Piaggi P; Maffei M; Santini F
+Author NameID
+ Ceccarini, Giovanni; ORCID: https://orcid.org/0000-0003-0701-642X
+Authors Full Name
+ Ceccarini, Giovanni; Pelosini, Caterina; Ferrari, Federica; Magno, Silvia; Vitti, Jacopo; Salvetti, Guido; Moretto, Carlo; Marioni, Antonio; Buccianti, Piero; Piaggi, Paolo; Maffei, Margherita; Santini, Ferruccio.
+Institution
+ Ceccarini, Giovanni. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy. giovanni.ceccarini@unipi.it.
+ Pelosini, Caterina. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
+ Ferrari, Federica. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
+ Magno, Silvia. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
+ Vitti, Jacopo. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
+ Salvetti, Guido. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
+ Moretto, Carlo. Unit of Bariatric Surgery, University Hospital of Pisa, Pisa, Italy.
+ Marioni, Antonio. Unit of Surgery, University Hospital of Pisa, Pisa, Italy.
+ Buccianti, Piero. Unit of Surgery, University Hospital of Pisa, Pisa, Italy.
+ Piaggi, Paolo. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
+ Piaggi, Paolo. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, United States.
+ Maffei, Margherita. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
+ Maffei, Margherita. Institute of Clinical Physiology, Italian National Research Council, Pisa, Italy.
+ Santini, Ferruccio. Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
+MeSH Subject Headings
+ Adult
+ Biomarkers/an [Analysis]
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ Drug Resistance
+ Female
+ *Gastric Bypass
+ Humans
+ Insulin-Like Growth Factor Binding Protein 2/an [Analysis]
+ *Insulin-Like Growth Factor Binding Protein 2/bl [Blood]
+ *Leptin/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/me [Metabolism]
+ *Obesity/su [Surgery]
+ Postoperative Period
+ Prognosis
+ Treatment Outcome
+ Young Adult
+Keyword Heading
+ Bariatric surgery
+ Gastric bypass
+ IGFBP-2
+ Leptin sensitivity
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Expression of IGFBP-2 in mice is regulated by leptin. Over-expression of IGFBP-2 is associated with reduced caloric intake and resistance to weight gain. Hormonal variations contributing to weight loss occur very early after bariatric surgery but have not been fully elucidated. We evaluated IGFBP-2 serum changes after bariatric surgery and their relationship with leptin variations to test the hypothesis that an increase of leptin sensitivity may explain some of the effects of gastric bypass.
+
+ METHODS: This is a historical prospective study. Fifty-one obese patients (41 women e 10 men), 9 non-obese surgical controls and 41 lean matched controls were studied. Serum IGFBP-2 and leptin were measured after bariatric bypass surgery at various time points up to 18 months, after non-bariatric laparoscopic surgery in a control group, and in lean matched controls.
+
+ RESULTS: Compared to lean controls, serum IGFBP-2 levels were lower in obese patients. After gastric bypass, IGFBP-2 significantly increased at 3 days and became normal before the occurrence of relevant changes in body weight, remaining stable up to 18 months after surgery. IGFBP-2/leptin ratio increased early after surgery and became normal after one year.
+
+ CONCLUSIONS: After gastric bypass, serum IGFBP-2 increases in a window of time when variations of hormones mediating the effects of bariatric surgery occur. Our results suggest that IGFBP-2, a leptin-regulated protein, may be an in-vivo marker of leptin action. If this is the case, an early improvement of leptin sensitivity might contribute to the anorectic effect of gastric bypass.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin-Like Growth Factor Binding Protein 2). 0 (Leptin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs12020-019-01915-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ceccarini&issn=1355-008X&title=Endocrine&atitle=Serum+IGF-binding+protein+2+%28IGFBP-2%29+concentrations+change+early+after+gastric+bypass+bariatric+surgery+revealing+a+possible+marker+of+leptin+sensitivity+in+obese+subjects.&volume=65&issue=1&spage=86&epage=93&date=2019&doi=10.1007%2Fs12020-019-01915-y&pmid=30945111&sid=OVID:medline
+
+<1717>
+Unique Identifier
+ 30944546
+Title
+ Soluble Receptor for Advanced Glycation End Products: A Protective Molecule against Intramyocardial Lipid Accumulation in Obese Zucker Rats?.
+Source
+ Mediators of Inflammation. 2019:2712376, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dozio E; Vianello E; Bandera F; Longhi E; Brizzola S; Nebuloni M; Corsi Romanelli MM
+Author NameID
+ Dozio, Elena; ORCID: https://orcid.org/0000-0001-5833-0780
+ Vianello, Elena; ORCID: https://orcid.org/0000-0001-6461-654X
+ Corsi Romanelli, Massimiliano M; ORCID: https://orcid.org/0000-0001-7928-7697
+Authors Full Name
+ Dozio, Elena; Vianello, Elena; Bandera, Francesco; Longhi, Erika; Brizzola, Stefano; Nebuloni, Manuela; Corsi Romanelli, Massimiliano M.
+Institution
+ Dozio, Elena. Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, Italy.
+ Vianello, Elena. Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, Italy.
+ Bandera, Francesco. Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, Italy.
+ Bandera, Francesco. Department of Cardiology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy.
+ Longhi, Erika. Department of Biomedical and Clinical Sciences "Luigi Sacco", Universita degli Studi di Milano, Milan, Italy.
+ Brizzola, Stefano. Department of Veterinary Medicine, Universita degli Studi di Milano, Milan, Italy.
+ Nebuloni, Manuela. Department of Biomedical and Clinical Sciences "Luigi Sacco", Universita degli Studi di Milano, Milan, Italy.
+ Corsi Romanelli, Massimiliano M. Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, Italy.
+ Corsi Romanelli, Massimiliano M. Service of Laboratory Medicine-Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Blotting, Western
+ Enzyme-Linked Immunosorbent Assay
+ *Glycation End Products, Advanced/me [Metabolism]
+ *Lipid Metabolism/ph [Physiology]
+ Lipids
+ Male
+ *Myocardium/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ Rats
+ Rats, Zucker
+ Real-Time Polymerase Chain Reaction
+ *Receptor for Advanced Glycation End Products/me [Metabolism]
+Abstract
+ Most of the obesity-related complications are due to ectopic fat accumulation. Recently, the activation of the cell-surface receptor for advanced glycation end products (RAGE) has been associated with lipid accumulation in different organs. Nevertheless, the role of RAGE and sRAGE, the soluble form that prevents ligands to activate RAGE, in intramyocardial lipid accumulation is presently unknown. To this aim, we analyzed whether, in obesity, intramyocardial lipid accumulation and lipid metabolism-related transcriptome are related to RAGE and sRAGE. Heart and serum samples were collected from 10 lean (L) and 10 obese (OB) Zucker rats. Oil red staining was used to detect lipids on frozen heart sections. The lipid metabolism-related transcriptome (84 genes) was analyzed by a specific PCR array. Heart RAGE expression was explored by real-time RT-PCR and Western blot analyses. Serum levels of sRAGE (total and endogenous secretory form (esRAGE)) were quantified by ELISA. Genes promoting fatty acid transport, activation, and oxidation in mitochondria/peroxisomes were upregulated in OB hearts. Intramyocardial lipid content did not differ between OB and L rats, as well as RAGE expression. A slight increase in epicardial adipose tissue was observed in OB hearts. Total sRAGE and esRAGE concentrations were significantly higher in OB rats. sRAGE may protect against obesity-induced intramyocardial lipid accumulation by preventing RAGE hyperexpression, therefore allowing lipids to be metabolized. EAT also played a protective role by working as a buffering system that protects the myocardium against exposure to excessively high levels of fatty acids. These observations reinforce the potential role of RAGE pathway as an interesting therapeutic target for obesity-related complications, at least at the cardiovascular level.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycation End Products, Advanced). 0 (Lipids). 0 (Receptor for Advanced Glycation End Products).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f2712376
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dozio&issn=0962-9351&title=Mediators+of+Inflammation&atitle=Soluble+Receptor+for+Advanced+Glycation+End+Products%3A+A+Protective+Molecule+against+Intramyocardial+Lipid+Accumulation+in+Obese+Zucker+Rats%3F.&volume=2019&issue=&spage=2712376&epage=&date=2019&doi=10.1155%2F2019%2F2712376&pmid=30944546&sid=OVID:medline
+
+<1718>
+Unique Identifier
+ 30935970
+Title
+ Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice.
+Source
+ Toxicology. 420:11-20, 2019 05 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chi Y; Wang H; Lin Y; Lu Y; Huang Q; Ye G; Dong S
+Authors Full Name
+ Chi, Yulang; Wang, Hongou; Lin, Yi; Lu, Yanyang; Huang, Qiansheng; Ye, Guozhu; Dong, Sijun.
+Institution
+ Chi, Yulang. KeyLab of Urban Environmentand Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China; Centerfor Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
+ Wang, Hongou. KeyLab of Urban Environmentand Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China; Centerfor Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
+ Lin, Yi. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China. Electronic address: tjlinyi@xmu.edu.cn.
+ Lu, Yanyang. KeyLab of Urban Environmentand Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
+ Huang, Qiansheng. KeyLab of Urban Environmentand Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China; Centerfor Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
+ Ye, Guozhu. KeyLab of Urban Environmentand Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China; Centerfor Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
+ Dong, Sijun. KeyLab of Urban Environmentand Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China; Centerfor Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China. Electronic address: sjdong@iue.ac.cn.
+MeSH Subject Headings
+ Animals
+ *Bacteria/de [Drug Effects]
+ Bacteria/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Dysbiosis
+ *Energy Metabolism/de [Drug Effects]
+ Fatty Liver/bl [Blood]
+ *Fatty Liver/ci [Chemically Induced]
+ Fatty Liver/mi [Microbiology]
+ Female
+ *Gastrointestinal Microbiome/de [Drug Effects]
+ Hyperlipidemias/bl [Blood]
+ *Hyperlipidemias/ci [Chemically Induced]
+ Hyperlipidemias/mi [Microbiology]
+ *Intestines/mi [Microbiology]
+ *Lipids/bl [Blood]
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ *Obesity/ci [Chemically Induced]
+ Obesity/mi [Microbiology]
+ *Polychlorinated Biphenyls/to [Toxicity]
+ Risk Factors
+ Sex Factors
+Keyword Heading
+ Bacterial function
+ Gut microbiota
+ Lipid metabolism
+ Polychlorinated biphenyl
+ Specific strain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Although the production of polychlorinated biphenyl 77 (PCB77) has already been banned globally, PCB77 is still used for a wide range of commercial purposes. Previous evidence has demonstrated that the PCB77 administration should be responsible for the gut microbiota variations and the host health risk. However, the host disorders and bacterial functions involved in PCB77 exposure remain largely unknown. Few studies have been performed to illuminate the correlation between the bacterial functions and disorders. Furthermore, it is urgently needed to find specific strains as potential biomarkers to monitor PCB77 pollution and associated disorders. This study was designed to investigate the effects of PCB77 on gut microbiota and induced disorders in female mice. Obtained results indicated that PCB77 exposure induced gut microbiota dysbiosis, obesity, hyperlipidemia, hepatic lipid accumulation, and liver injury in mice. Functional prediction based on the phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) algorithm showed that exposure to PCB77 weakened the bacterial functions relating to lipid and energy metabolism, and immune system disease. Experimental findings were consistent with the result of the PICRUSt functional prediction. Importantly, three PCB77-associated bacterial taxa were screened out as potential biomarkers for the assessment of PCB77 pollution. This study provides previously unknown knowledge linking PCB77 administration, gut microbiota functional profile and lipid abnormalities, which is of important clinical significance for therapies treating PCB77-associated diseases. Copyright © 2019 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). DFC2HB4I0K (Polychlorinated Biphenyls). Y2I6546TMI (3,4,3',4'-tetrachlorobiphenyl).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.tox.2019.03.011
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chi&issn=0300-483X&title=Toxicology&atitle=Gut+microbiota+characterization+and+lipid+metabolism+disorder+found+in+PCB77-treated+female+mice.&volume=420&issue=&spage=11&epage=20&date=2019&doi=10.1016%2Fj.tox.2019.03.011&pmid=30935970&sid=OVID:medline
+
+<1719>
+Unique Identifier
+ 30929550
+Title
+ Galectin-3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients.
+Source
+ Journal of the American Heart Association. 8(7):e011100, 2019 04 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gopal DM; Ayalon N; Wang YC; Siwik D; Sverdlov A; Donohue C; Perez A; Downing J; Apovian C; Silva V; Panagia M; Kolachalama V; Ho JE; Liang CS; Gokce N; Colucci WS
+Authors Full Name
+ Gopal, Deepa M; Ayalon, Nir; Wang, Yi-Chih; Siwik, Deborah; Sverdlov, Aaron; Donohue, Courtney; Perez, Alejandro; Downing, Jill; Apovian, Caroline; Silva, Vanessa; Panagia, Marcello; Kolachalama, Vijaya; Ho, Jennifer E; Liang, Chang-Seng; Gokce, Noyan; Colucci, Wilson S.
+Institution
+ Gopal, Deepa M. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Ayalon, Nir. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Wang, Yi-Chih. 4 Cardiovascular Division Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan.
+ Siwik, Deborah. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Sverdlov, Aaron. 5 School of Medicine and Public Health University of Newcastle New South Wales Australia.
+ Perez, Alejandro. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Downing, Jill. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Apovian, Caroline. 2 Endocrinology Section Department of Medicine Boston University School of Medicine Boston MA.
+ Silva, Vanessa. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Panagia, Marcello. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Kolachalama, Vijaya. 3 Computational Biomedicine Department of Medicine Boston University School of Medicine Boston MA.
+ Ho, Jennifer E. 6 Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA.
+ Liang, Chang-Seng. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Gokce, Noyan. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+ Colucci, Wilson S. 1 Cardiovascular Medicine Section Department of Medicine Boston University School of Medicine Boston MA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Blood Proteins
+ Case-Control Studies
+ Echocardiography
+ Female
+ Follistatin-Related Proteins/me [Metabolism]
+ *Galectin 3/me [Metabolism]
+ Galectins
+ *Heart Failure/di [Diagnosis]
+ Heart Failure/pp [Physiopathology]
+ Hemodynamics/ph [Physiology]
+ Humans
+ *Hypertension, Pulmonary/di [Diagnosis]
+ Hypertension, Pulmonary/pp [Physiopathology]
+ Hypertrophy, Left Ventricular/di [Diagnosis]
+ Male
+ *Metabolic Diseases/di [Diagnosis]
+ Metabolic Diseases/pp [Physiopathology]
+ Middle Aged
+ Natriuretic Peptide, Brain/me [Metabolism]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Peptide Fragments/me [Metabolism]
+Keyword Heading
+ echocardiography
+ obesity
+ prevention
+ remodeling heart failure
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease ( MHD ) in young obese patients would help identify high-risk individuals for heart failure prevention strategies. We assessed the predictive value of GAL3 (galectin-3), FSTL3 (follistatin-like 3 peptide), and NT-proBNP (N-terminal pro-B-type natriuretic peptide) to identify stage B MHD in young obese participants free of clinically evident cardiovascular disease. Methods and Results Asymptomatic obese patients (n=250) and non-obese controls (n=21) underwent echocardiographic cardiac phenotyping. Obese patients were classified as MHD positive ( MHD - POS ; n=94) if they had abnormal diastolic function or left ventricular hypertrophy and had estimated pulmonary artery systolic pressure >=35 mm Hg. Obese patients without such abnormalities were classified as MHD negative (MHD-NEG; n=52). Serum biomarkers timed with echocardiography. MHD - POS and MHD-NEG individuals were similarly obese, but MHD - POS patients were older, with more diabetes mellitus and metabolic syndrome. Right ventricular coupling was worse in MHD - POS patients ( P<0.001). GAL 3 levels were higher in MHD - POS versus MHD -NEG patients (7.7+/-2.3 versus 6.3+/-1.9 ng/mL, respectively; P<0.001). Both GAL 3 and FSTL 3 levels correlated with diastolic dysfunction and increased pulmonary artery systolic pressure but not with left ventricular mass. In multivariate models including all 3 biomarkers, only GAL 3 remained associated with MHD (odds ratio: 1.30; 95% CI , 1.01-1.68; P=0.04). Conclusions In young obese individuals without known cardiovascular disease, GAL 3 is associated with the presence of preclinical MHD . GAL 3 may be useful in screening for preclinical MHD and identifying individuals with increased risk of progression to obesity-related heart failure with preserved ejection fraction.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Proteins). 0 (Follistatin-Related Proteins). 0 (Fstl3 protein, human). 0 (Galectin 3). 0 (Galectins). 0 (LGALS3 protein, human). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1161%2fJAHA.118.011100
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gopal&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Galectin-3+Is+Associated+With+Stage+B+Metabolic+Heart+Disease+and+Pulmonary+Hypertension+in+Young+Obese+Patients.&volume=8&issue=7&spage=e011100&epage=&date=2019&doi=10.1161%2FJAHA.118.011100&pmid=30929550&sid=OVID:medline
+
+<1720>
+Unique Identifier
+ 30926848
+Title
+ BRD7 deficiency leads to the development of obesity and hyperglycemia.
+Source
+ Scientific Reports. 9(1):5327, 2019 03 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee JM; Kim Y; Salazar Hernandez MA; Han Y; Liu R; Park SW
+Author NameID
+ Park, Sang Won; ORCID: http://orcid.org/0000-0001-7764-3133
+Authors Full Name
+ Lee, Junsik M; Kim, Yoo; Salazar Hernandez, Mario Andres; Han, Youngah; Liu, Renyan; Park, Sang Won.
+Institution
+ Lee, Junsik M. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
+ Kim, Yoo. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
+ Salazar Hernandez, Mario Andres. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
+ Han, Youngah. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
+ Liu, Renyan. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
+ Park, Sang Won. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. sangwon.park@childrens.harvard.edu.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Blood Glucose
+ Body Weight
+ *Chromosomal Proteins, Non-Histone/df [Deficiency]
+ Disease Models, Animal
+ Genetic Association Studies
+ *Genetic Predisposition to Disease
+ Genotype
+ Homeostasis
+ *Hyperglycemia/bl [Blood]
+ Hyperglycemia/di [Diagnosis]
+ *Hyperglycemia/ge [Genetics]
+ Insulin/me [Metabolism]
+ Insulin Resistance
+ Liver/me [Metabolism]
+ Mice
+ Mice, Knockout
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ge [Genetics]
+Abstract
+ Obesity is a debilitating disease that has become a global epidemic. Although progress is being made, the underlying molecular mechanism by which obesity develops still remains elusive. Recently, we reported that the expression levels of bromodomain-containing protein 7 (BRD7) are significantly reduced in the liver of obese mice. However, it is not clear whether decreased levels of hepatic BRD7 are directly associated with the development of obesity and disturbance in glucose homeostasis. Here, using heterozygous BRD7 knockout and liver-specific BRD7 knockout mouse models, we report that reduced BRD7 levels lead to increased weight gain with little effect on glucose metabolism. On the other hand, upregulating BRD7 in the liver starting at an early age protects mice from gaining excessive weight and developing glucose intolerance and insulin resistance when challenged with a high-fat diet.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Brd7 protein, mouse). 0 (Chromosomal Proteins, Non-Histone). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-41713-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=2045-2322&title=Scientific+Reports&atitle=BRD7+deficiency+leads+to+the+development+of+obesity+and+hyperglycemia.&volume=9&issue=1&spage=5327&epage=&date=2019&doi=10.1038%2Fs41598-019-41713-0&pmid=30926848&sid=OVID:medline
+
+<1721>
+Unique Identifier
+ 30924428
+Title
+ Gut Prevotella as a possible biomarker of diet and its eubiotic versus dysbiotic roles: a comprehensive literature review.
+Source
+ British Journal of Nutrition. 122(2):131-140, 2019 07 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Precup G; Vodnar DC
+Authors Full Name
+ Precup, Gabriela; Vodnar, Dan-Cristian.
+Institution
+ Precup, Gabriela. Faculty of Food Science and Technology, Institute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, CJ, Romania.
+ Vodnar, Dan-Cristian. Faculty of Food Science and Technology, Institute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, CJ, Romania.
+MeSH Subject Headings
+ *Biomarkers
+ *Diet
+ Dietary Fiber/ad [Administration & Dosage]
+ *Dysbiosis/mi [Microbiology]
+ Feeding Behavior/ph [Physiology]
+ *Gastrointestinal Microbiome
+ Gastrointestinal Tract/mi [Microbiology]
+ Humans
+ Metabolic Syndrome/mi [Microbiology]
+ Obesity/mi [Microbiology]
+ Plants, Edible
+ Polysaccharides/me [Metabolism]
+ *Prevotella/ph [Physiology]
+Keyword Heading
+ Dietary patterns
+ Gut microbiota
+ Prevotella
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The gut microbiota has a profound impact on human health. Emerging data show that dietary patterns are associated with different communities of bacterial species within the gut. Prevotella species have been correlated with plant-rich diets, abundant in carbohydrates and fibres. Dysbiosis within the gut ecosystem has been associated with the development of non-communicable diseases such as obesity, the metabolic syndrome, inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, type 1 diabetes, allergies and other diseases. The purpose of this comprehensive literature review was to evaluate the available data on the impact of diet on the Prevotella genus, as a dietary fibre fermenter in the gut as well as its implications as a potential biomarker for homeostasis or disease state through its metabolite signature. Studies were identified by conducting PubMed, Web of Science Core Collection and Google Scholar electronic searches. We found eighty-five publications reporting the impact of dietary patterns on gut microbial communities, including Prevotella or Prevotella/Bacteroides ratio in particular. Moreover, the role of Prevotella species on health status was also evaluated. Prevotella possess a high genetic diversity, representing one of the important groups found in the oral cavity and large intestine of man. The gut commensal Prevotella bacteria contribute to polysaccharide breakdown, being dominant colonisers of agrarian societies. However, studies also suggested a potential role of Prevotella species as intestinal pathobionts. Further metagenomic studies are needed in order to reveal health- or disease-modulating properties of Prevotella species in the gut.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fiber). 0 (Polysaccharides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1017%2fS0007114519000680
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Precup&issn=0007-1145&title=British+Journal+of+Nutrition&atitle=Gut+Prevotella+as+a+possible+biomarker+of+diet+and+its+eubiotic+versus+dysbiotic+roles%3A+a+comprehensive+literature+review.&volume=122&issue=2&spage=131&epage=140&date=2019&doi=10.1017%2FS0007114519000680&pmid=30924428&sid=OVID:medline
+
+<1722>
+Unique Identifier
+ 30921666
+Title
+ Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects.
+Source
+ Growth Hormone & Igf Research. 45:31-36, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang X; Gu HF; Frystyk J; Efendic S; Brismar K; Thorell A
+Authors Full Name
+ Zhang, Xiuli; Gu, Harvest F; Frystyk, Jan; Efendic, Suad; Brismar, Kerstin; Thorell, Anders.
+Institution
+ Zhang, Xiuli. Department of Nephrology, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Guangdong 518000, China.
+ Gu, Harvest F. Center for Pathophysiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: feng.gu@cpu.edu.cn.
+ Frystyk, Jan. Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense DK-5000, Denmark; Department of Clinical Medicine Health, Aarhus University, Aarhus C DK-8000, Denmark. Electronic address: Jan.Frystyk@rsyd.dk.
+ Efendic, Suad. Rolf Luft Center for Diabetes Research and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden. Electronic address: Enes.Efendic@erstadiakoni.se.
+ Brismar, Kerstin. Rolf Luft Center for Diabetes Research and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden; Department of Endocrinology, Diabetes and Metabolism, Karolinska University Hospital, Stockholm, Sweden. Electronic address: Kerstin.brismar@ki.se.
+ Thorell, Anders. Department of Clinical Science, Danderyds Hospital, Karolinska Institutet, Danderyd, Stockholm 18288, Sweden; Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm 11691, Sweden. Electronic address: Anders.Thorell@erstadiakoni.se.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Case-Control Studies
+ *DNA Methylation
+ Epigenesis, Genetic
+ Female
+ Follow-Up Studies
+ Humans
+ Insulin Resistance
+ *Insulin-Like Growth Factor Binding Protein 2/ge [Genetics]
+ *Insulin-Like Growth Factor Binding Protein 2/me [Metabolism]
+ *Intra-Abdominal Fat/me [Metabolism]
+ Intra-Abdominal Fat/pa [Pathology]
+ Leptin/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Prognosis
+ RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+ *Subcutaneous Fat/me [Metabolism]
+ Subcutaneous Fat/pa [Pathology]
+Keyword Heading
+ Adipose tissues
+ DNA methylation
+ IGFBP2
+ Obesity
+ mRNA expression
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Insulin-like growth factor binding-protein 2 (IGFBP-2) is secreted by differentiating white adipocytes. Clinical studies demonstrate that circulating IGFBP-2 levels associated inversely with body mass index (BMI) and insulin resistance. To explore possible epigenetic changes of the IGFBP2 gene in obesity, we analyzed DNA methylation and mRNA expression in adipocytes from different depots. Healthy lean controls (BMI=24.5+/-0.3kg/m2, n=19) and obese subjects (BMI>35kg/m2, n=24) were recruited. All subjects were Swedish Caucasian. Visceral abdominal adipose tissue (VAT) and subcutaneous adipose tissue (SAT) fragments were homogenized. Genomic DNA and total RNAs were extracted. Four CpG sites in the IGFBP2 gene promoter region were analyzed with bisulfite pyrosequencing. IGFBP2 gene expression at mRNA levels was determined with TaqMan real time RT-PCR. Serum samples were used for measurement of circulating IGFBP-2 and leptin levels. IGFBP2 DNA methylation levels in VAT were increased in obese subjects compared with controls (P<.05). By contrast, IGFBP2 mRNA expression levels in VAT were lower in obesity subjects than in controls (P<.05). In SAT, IGFBP2 DNA methylation and RNA expression levels were lower than in VAT, irrespective of obesity. Obese subjects demonstrated increased serum leptin levels (P<.001) and reduced serum IGFBP-2 levels compared to controls (P<.05). In conclusion, the current study demonstrates that IGFBP2 DNA methylation levels are increased in VAT from obese subjects. This suggests that IGFBP-2 is epigenetically regulated in abdominal obesity. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin-Like Growth Factor Binding Protein 2). 0 (Leptin). 0 (RNA, Messenger).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ghir.2019.03.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1096-6374&title=Growth+Hormone+%26+Igf+Research&atitle=Analyses+of+IGFBP2+DNA+methylation+and+mRNA+expression+in+visceral+and+subcutaneous+adipose+tissues+of+obese+subjects.&volume=45&issue=&spage=31&epage=36&date=2019&doi=10.1016%2Fj.ghir.2019.03.002&pmid=30921666&sid=OVID:medline
+
+<1723>
+Unique Identifier
+ 30920872
+Title
+ A cross-sectional cohort study of gingival crevicular fluid biomarkers in normal-weight and obese subjects during orthodontic treatment with fixed appliances.
+Source
+ Angle Orthodontist. 89(6):930-935, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Saloom HF; Carpenter GH; Cobourne MT
+Authors Full Name
+ Saloom, Hayder F; Carpenter, Guy H; Cobourne, Martyn T.
+MeSH Subject Headings
+ Adult
+ Biomarkers/an [Analysis]
+ *Biomarkers
+ Cohort Studies
+ Cross-Sectional Studies
+ Female
+ Gingival Crevicular Fluid/ch [Chemistry]
+ *Gingival Crevicular Fluid
+ Humans
+ Male
+ *Obesity
+ *Orthodontic Appliances, Fixed
+Keyword Heading
+ Biomarkers
+ GCF
+ Obesity
+ Orthodontics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To investigate the effects of obesity on biomarker levels within lower incisor gingival crevicular fluid (GCF) in subjects undergoing routine fixed appliance orthodontic treatment.
+
+ MATERIALS AND METHODS: This was a cross-sectional clinical cohort study. GCF was collected from normal-weight and obese subjects at completion of alignment at least 1 month after placement of 0.019 x 0.025-inch stainless-steel archwires. The primary outcome was the difference in GCF biomarker levels between groups. Secondary outcomes included differences in clinical parameters of plaque and gingival indices, unstimulated whole-mouth saliva, and GCF flow rates.
+
+ RESULTS: Thirty-eight subjects (18 male, 20 female) with a mean age of 25.6 (SD, 6.3) years and mean body mass index (BMI) of 22.6 (1.6) in normal-weight and 32.4 (2.2) kg/m2 in obese groups were investigated. Apart from BMI (P < .0001), there were no statistically significant differences in essential demographics between groups. Significantly increased levels of the adipokine leptin (P < .009) and the tissue-remodeling biomarker matrix metalloproteinase-9 (MMP9; P < .020) were identified in the obese cohort. For the remainder of the biomarkers, including the RANKL bone-remodeling marker and several inflammatory markers, there were no significant differences between groups. No correlation was observed between plaque index or gingival index for any GCF biomarker for either group (P = .07-1.00).
+
+ CONCLUSIONS: This study investigated the GCF biochemical profile of obese and normal-weight subjects undergoing fixed-appliance orthodontic treatment. Significantly increased levels of the adipokine leptin and the tissue-remodeling biomarker MMP9 were identified in the obese group. These data provide evidence of differences in GCF biochemistry between obese and normal-weight subjects undergoing fixed appliance orthodontic treatment.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2319%2f100518-719.1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Saloom&issn=0003-3219&title=Angle+Orthodontist&atitle=A+cross-sectional+cohort+study+of+gingival+crevicular+fluid+biomarkers+in+normal-weight+and+obese+subjects+during+orthodontic+treatment+with+fixed+appliances.&volume=89&issue=6&spage=930&epage=935&date=2019&doi=10.2319%2F100518-719.1&pmid=30920872&sid=OVID:medline
+
+<1724>
+Unique Identifier
+ 30919338
+Title
+ Circular RNAs as Potential Biomarkers and Therapeutic Targets for Metabolic Diseases. [Review]
+Source
+ Advances in Experimental Medicine & Biology. 1134:177-191, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zaiou M
+Authors Full Name
+ Zaiou, Mohamed.
+Institution
+ Zaiou, Mohamed. University of Lorraine, School of Pharmacy, Vandoeuvre les Nancy Cedex, France. mohamed.zaiou@univ-lorraine.fr.
+MeSH Subject Headings
+ *Biomarkers/an [Analysis]
+ *Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/th [Therapy]
+ Humans
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/th [Therapy]
+ *Obesity/di [Diagnosis]
+ Obesity/th [Therapy]
+ *RNA/ge [Genetics]
+ RNA, Circular
+ RNA, Untranslated
+Keyword Heading
+ Circular RNAs (circRNAs)
+ Diabetes
+ Epigenetics
+ Metabolic Diseases
+ NAFLD
+ Noncoding RNAs (ncRNAs)
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Epidemiological studies provide evidence of a continuous rise in metabolic diseases throughout industrialized countries. Metabolic diseases are commonly associated with different abnormalities that hold a key role in the emergence and progression of frequent disorders including diabetes mellitus (DM), non-alcoholic fatty liver disease (NAFLD), obesity, metabolic syndrome and cardiovascular diseases. The burden of metabolic diseases is believed to arise through complex interaction between genetic and epigenetic factors, lifestyle changes and environmental exposure to triggering stimuli. The diagnosis and treatment of metabolic disorders continue to be an overwhelming challenge. Thus, the development of novel biomarkers may enhance the accuracy of the diagnosis at an early stage of the disease and allow effective intervention. Over the past decade, progress has been made in exploring the potential role of noncoding RNAs (ncRNAs) in the regulation of gene networks involved in metabolic diseases. A growing body of evidence now suggests that aberrant expression of circular RNAs (circRNAs) is relevant to the occurrence and development of metabolic diseases. Accordingly, circRNAs are proposed as predictive biomarkers and potential therapeutic targets for these diseases. As the field of circRNAs is rapidly evolving and knowledge is increasing, the present paper provides current understanding of the regulatory roles of these RNA species mainly in the pathogenesis of DM, NAFLD and obesity. Furthermore, some of the limitations to the promise of circRNAs and perspectives on their future research are discussed.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Circular). 0 (RNA, Untranslated). 63231-63-0 (RNA).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2f978-3-030-12668-1_10
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zaiou&issn=0065-2598&title=Advances+in+Experimental+Medicine+%26+Biology&atitle=Circular+RNAs+as+Potential+Biomarkers+and+Therapeutic+Targets+for+Metabolic+Diseases.&volume=1134&issue=&spage=177&epage=191&date=2019&doi=10.1007%2F978-3-030-12668-1_10&pmid=30919338&sid=OVID:medline
+
+<1725>
+Unique Identifier
+ 30918134
+Title
+ Circulating zinc-alpha2-glycoprotein is reduced in women with polycystic ovary syndrome, but can be increased by exenatide or metformin treatment.
+Source
+ Endocrine Journal. 66(6):555-562, 2019 Jun 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zheng S; Liu E; Zhang Y; Long T; Liu X; Gong Y; Mai T; Shen H; Chen H; Lin R; Zheng Y; Xie Y; Wang F
+Authors Full Name
+ Zheng, Siyuan; Liu, En; Zhang, Ying; Long, Tao; Liu, Xin; Gong, Yi; Mai, Tingting; Shen, Huanling; Chen, Hui; Lin, Rong; Zheng, Yongxiong; Xie, Yijuan; Wang, Fang.
+Institution
+ Zheng, Siyuan. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Liu, En. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Zhang, Ying. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Long, Tao. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Liu, Xin. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Gong, Yi. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Mai, Tingting. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Shen, Huanling. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Chen, Hui. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Lin, Rong. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Zheng, Yongxiong. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Xie, Yijuan. Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+ Wang, Fang. Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
+MeSH Subject Headings
+ Adipokines
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ *Carrier Proteins/bl [Blood]
+ *Exenatide/tu [Therapeutic Use]
+ Female
+ *Glycoproteins/bl [Blood]
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ *Metformin/tu [Therapeutic Use]
+ Obesity/bl [Blood]
+ Overweight/bl [Blood]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/dt [Drug Therapy]
+ Treatment Outcome
+Keyword Heading
+ Exenatide
+ Insulin resistance
+ Obesity
+ Polycystic ovarian syndrome
+ Zinc-alpha2-glycoprotein
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The study was to investigate circulating zinc-alpha2-glycoprotein (ZAG) concentrations in women with PCOS, and changes in ZAG levels after exenatide or metformin treatment. One hundred eighty-two women with polycystic ovary syndrome (PCOS) who met the 2003 Rotterdam diagnostic criteria and 150 controls without PCOS were recruited. We partitioned women with PCOS into groups according to body mass index or blood glucose concentrations, determined serum ZAG, anthropometric parameters, metabolic and endocrine indicators, and inflammatory markers, and statistically analyzed the results. Eighty-two overweight/obese subjects of the recruited women with PCOS were then randomly assigned to groups administered either 12 weeks of exenatide injection (10 mug b.i.d.) or oral metformin (1,000 mg b.i.d.). Circulating ZAG levels were determined after 12 weeks of treatment. The results showed that circulating ZAG was significantly lower in PCOS women than in healthy women (p < 0.01). Overweight/obese women and those with higher blood glucose levels had lower circulating ZAG. After 12 weeks of exenatide or metformin treatment, there were significant increases (p < 0.01) in circulating ZAG in both treatment groups (the exenatide baseline level was 46.54 +/- 2.38 ng/mL vs. 56.41 +/- 2.02 ng/mL after treatment, p < 0.01; metformin baseline was 47.81 +/- 2.14 ng/mL vs. 55.67 +/- 2.01 ng/mL after treatment, p < 0.01), however there was no statistical difference between the 2 treatments (p > 0.05). Circulating ZAG is closely related to PCOS and could be an important adipokine involved in the occurrence and development of PCOS. ZAG might possibly be applicable as a new observational indicator in the treatment of PCOS.
+Registry Number/Name of Substance
+ 0 (AZGP1 protein, human). 0 (Adipokines). 0 (Biomarkers). 0 (Blood Glucose). 0 (Carrier Proteins). 0 (Glycoproteins). 0 (Hypoglycemic Agents). 9100L32L2N (Metformin). 9P1872D4OL (Exenatide).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1507%2fendocrj.EJ18-0153
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zheng&issn=0918-8959&title=Endocrine+Journal&atitle=Circulating+zinc-alpha2-glycoprotein+is+reduced+in+women+with+polycystic+ovary+syndrome%2C+but+can+be+increased+by+exenatide+or+metformin+treatment.&volume=66&issue=6&spage=555&epage=562&date=2019&doi=10.1507%2Fendocrj.EJ18-0153&pmid=30918134&sid=OVID:medline
+
+<1726>
+Unique Identifier
+ 30913263
+Title
+ Non-invasive assessment of NAFLD as systemic disease-A machine learning perspective.
+Source
+ PLoS ONE [Electronic Resource]. 14(3):e0214436, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Canbay A; Kalsch J; Neumann U; Rau M; Hohenester S; Baba HA; Rust C; Geier A; Heider D; Sowa JP
+Author NameID
+ Canbay, Ali; ORCID: https://orcid.org/0000-0001-6069-7899
+Authors Full Name
+ Canbay, Ali; Kalsch, Julia; Neumann, Ursula; Rau, Monika; Hohenester, Simon; Baba, Hideo A; Rust, Christian; Geier, Andreas; Heider, Dominik; Sowa, Jan-Peter.
+Institution
+ Canbay, Ali. Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
+ Kalsch, Julia. Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, Germany.
+ Kalsch, Julia. Institute for Pathology, University Hospital, University Duisburg-Essen, Essen, Germany.
+ Neumann, Ursula. Department of Mathematics and Computer Science, University of Marburg, Marburg, Germany.
+ Rau, Monika. Division of Hepatology, Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.
+ Hohenester, Simon. Department of Medicine II, University Hospital, LMU Munich, Munich, Germany.
+ Baba, Hideo A. Institute for Pathology, University Hospital, University Duisburg-Essen, Essen, Germany.
+ Rust, Christian. Center for Nutritional Medicine and Prevention, Department of Medicine I, Hospital Barmherzige Bruder, Munich, Germany.
+ Geier, Andreas. Division of Hepatology, Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.
+ Heider, Dominik. Department of Mathematics and Computer Science, University of Marburg, Marburg, Germany.
+ Sowa, Jan-Peter. Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
+ Sowa, Jan-Peter. Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, Germany.
+MeSH Subject Headings
+ Adult
+ Apoptosis
+ Biomarkers/me [Metabolism]
+ Body Weight
+ Cohort Studies
+ *Computational Biology/mt [Methods]
+ Female
+ Humans
+ *Machine Learning
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/co [Complications]
+Abstract
+ BACKGROUND & AIMS: Current non-invasive scores for the assessment of severity of non-alcoholic fatty liver disease (NAFLD) and identification of patients with non-alcoholic steatohepatitis (NASH) have insufficient performance to be included in clinical routine. In the current study, we developed a novel machine learning approach to overcome the caveats of existing approaches.
+
+ METHODS: Non-invasive parameters were selected by an ensemble feature selection (EFS) from a retrospectively collected training cohort of 164 obese individuals (age: 43.5+/-10.3y; BMI: 54.1+/-10.1kg/m2) to develop a model able to predict the histological assessed NAFLD activity score (NAS). The model was evaluated in an independent validation cohort (122 patients, age: 45.2+/-11.75y, BMI: 50.8+/-8.61kg/m2).
+
+ RESULTS: EFS identified age, gammaGT, HbA1c, adiponectin, and M30 as being highly associated with NAFLD. The model reached a Spearman correlation coefficient with the NAS of 0.46 in the training cohort and was able to differentiate between NAFL (NAS<=4) and NASH (NAS>4) with an AUC of 0.73. In the independent validation cohort, an AUC of 0.7 was achieved for this separation. We further analyzed the potential of the new model for disease monitoring in an obese cohort of 38 patients under lifestyle intervention for one year. While all patients lost weight under intervention, increasing scores were observed in 15 patients. Increasing scores were associated with significantly lower absolute weight loss, lower reduction of waist circumference and basal metabolic rate.
+
+ CONCLUSIONS: A newly developed model (http://CHek.heiderlab.de) can predict presence or absence of NASH with reasonable performance. The new score could be used to detect NASH and monitor disease progression or therapy response to weight loss interventions.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0214436
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Canbay&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Non-invasive+assessment+of+NAFLD+as+systemic+disease-A+machine+learning+perspective.&volume=14&issue=3&spage=e0214436&epage=&date=2019&doi=10.1371%2Fjournal.pone.0214436&pmid=30913263&sid=OVID:medline
+
+<1727>
+Unique Identifier
+ 30909605
+Title
+ Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy.
+Source
+ Nutrients. 11(3), 2019 03 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Flores-Quijano ME; Vega-Sanchez R; Tolentino-Dolores MC; Lopez-Alarcon MG; Flores-Urrutia MC; Lopez-Olvera AD; Talavera JO
+Authors Full Name
+ Flores-Quijano, Maria Eugenia; Vega-Sanchez, Rodrigo; Tolentino-Dolores, Mari Cruz; Lopez-Alarcon, Mardia Guadalupe; Flores-Urrutia, Monica Crissel; Lopez-Olvera, Ana Daniela; Talavera, Juan O.
+Institution
+ Flores-Quijano, Maria Eugenia. Departamento de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Ciudad de Mexico CP. 11000, Mexico. maru_fq@yahoo.com.
+ Vega-Sanchez, Rodrigo. Departamento de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Ciudad de Mexico CP. 11000, Mexico. vegarodrig@gmail.com.
+ Tolentino-Dolores, Mari Cruz. Departamento de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Ciudad de Mexico CP. 11000, Mexico. cruz_tolentino@yahoo.com.mx.
+ Lopez-Alarcon, Mardia Guadalupe. Unidad de Investigacion Medica en Nutricion, Centro Medico Nacional Siglo XXI. Instituto Mexicano del Seguro Social (IMSS), Ciudad de Mexico, CP. 06720, Mexico. marsau2@prodigy.net.mx.
+ Flores-Urrutia, Monica Crissel. Departamento de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Ciudad de Mexico CP. 11000, Mexico. fu.monicac@gmail.com.
+ Lopez-Olvera, Ana Daniela. Departamento de Ciencias de la Salud, Universidad del Valle de Mexico, Coyoacan, Ciudad de Mexico, CP. 04910, Mexico. a.daniela.lopez.o@gmail.com.
+ Talavera, Juan O. Direccion de Ensenanza e Investigacion. Centro Medico ABC, Ciudad de Mexico, CP. 01120, Mexico. jotalaverap@abchospital.com.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Dietary Supplements
+ Female
+ Ferritins/bl [Blood]
+ Hemoglobins/me [Metabolism]
+ Hepcidins/bl [Blood]
+ *Homeostasis
+ Humans
+ Inflammation/bl [Blood]
+ Iron/ad [Administration & Dosage]
+ *Iron/bl [Blood]
+ Linear Models
+ *Maternal Nutritional Physiological Phenomena/ph [Physiology]
+ Nutritional Status
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Pregnancy
+ *Pregnancy Complications/bl [Blood]
+ Pregnancy Complications/et [Etiology]
+ Pregnancy Complications/pp [Physiopathology]
+ Receptors, Transferrin/bl [Blood]
+ Young Adult
+Keyword Heading
+ ferritin
+ hemoglobin
+ hepcidin
+ iron
+ maternal obesity
+ pregnancy
+ serum iron
+ serum transferrin receptor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The influence of obesity on maternal iron homeostasis and nutrition status during pregnancy remains only partially clarified. Our study objectives were (1) to describe how obesity influences broad iron nutrition spectrum biomarkers such as available or circulating iron (serum transferrin receptor (sTfr) and serum iron), iron reserves (ferritin), and functional iron (hemoglobin); and (2) to depict the regulating role of hepcidin. The above was carried out while considering influential factors such as initial iron nutrition status, iron intake, and the presence of inflammation. Ninety three non-anemic pregnant adult women were included, 40 with obesity (Ob) and 53 with adequate weight (AW); all took =30 mg/day of supplementary iron. Information on iron intake and blood samples were obtained at gestational weeks 13, 20, 27, and 35. A series of repeated measure analyses were performed using General Linear Models to discern the effect of obesity on each iron indicator; iron intake, hepcidin, and C-reactive protein were successively introduced as covariates. Available and circulating iron was lower in obese women: sTfr was higher (p = 0.07) and serum iron was lower (p = 0.01); and ferritin and hemoglobin were not different between groups. Hepcidin was higher in the Ob group (p = 0.01) and was a significant predictor variable for all biomarkers. Obesity during pregnancy dysregulates iron homeostasis, resembling "obesity hypoferremia".
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hemoglobins). 0 (Hepcidins). 0 (Receptors, Transferrin). 9007-41-4 (C-Reactive Protein). 9007-73-2 (Ferritins). E1UOL152H7 (Iron).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11030693
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Flores-Quijano&issn=2072-6643&title=Nutrients&atitle=Obesity+Is+Associated+with+Changes+in+Iron+Nutrition+Status+and+Its+Homeostatic+Regulation+in+Pregnancy.&volume=11&issue=3&spage=&epage=&date=2019&doi=10.3390%2Fnu11030693&pmid=30909605&sid=OVID:medline
+
+<1728>
+Unique Identifier
+ 30909461
+Title
+ Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice.
+Source
+ International Journal of Molecular Sciences. 20(6), 2019 Mar 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Atawia RT; Toque HA; Meghil MM; Benson TW; Yiew NKH; Cutler CW; Weintraub NL; Caldwell RB; Caldwell RW
+Author NameID
+ Meghil, Mohamed M; ORCID: https://orcid.org/0000-0003-2344-3579
+Authors Full Name
+ Atawia, Reem T; Toque, Haroldo A; Meghil, Mohamed M; Benson, Tyler W; Yiew, Nicole K H; Cutler, Christopher W; Weintraub, Neal L; Caldwell, Ruth B; Caldwell, Robert W.
+Institution
+ Atawia, Reem T. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA. RATAWIA@augusta.edu.
+ Toque, Haroldo A. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA. HFLORESTOQUE@augusta.edu.
+ Toque, Haroldo A. Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA. HFLORESTOQUE@augusta.edu.
+ Meghil, Mohamed M. Department of Periodontics, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA. MMEGHIL@augusta.edu.
+ Meghil, Mohamed M. Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA. MMEGHIL@augusta.edu.
+ Benson, Tyler W. Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA. TBENSON@augusta.edu.
+ Yiew, Nicole K H. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA. KYIEW@wustl.edu.
+ Yiew, Nicole K H. Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA. KYIEW@wustl.edu.
+ Yiew, Nicole K H. Current address: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. KYIEW@wustl.edu.
+ Cutler, Christopher W. Department of Periodontics, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA. CHCUTLER@augusta.edu.
+ Cutler, Christopher W. Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA. CHCUTLER@augusta.edu.
+ Weintraub, Neal L. Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA. NWEINTRAUB@augusta.edu.
+ Caldwell, Ruth B. Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA. RCALDWEL@augusta.edu.
+ Caldwell, Ruth B. Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. RCALDWEL@augusta.edu.
+ Caldwell, Robert W. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA. WCALDWEL@augusta.edu.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipocytes/pa [Pathology]
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Animals
+ Arginase/ge [Genetics]
+ *Arginase/me [Metabolism]
+ Biomarkers
+ *Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ *Energy Metabolism
+ *Fatty Acids/me [Metabolism]
+ Fibrosis
+ Gene Deletion
+ Hypertrophy
+ Mice
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Oxidation-Reduction
+ Oxidative Stress
+ Oxygen Consumption
+ Sucrose/me [Metabolism]
+Keyword Heading
+ AMPK-alpha
+ arginase
+ endothelial dysfunction
+ fatty acid oxidation
+ inflammation
+ metabolism
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase enzyme with two isoforms (A1-cytosolic and A2-mitochondrial), is implicated in pathologies associated with obesity and diabetes. This study examined A2 involvement in obesity-associated metabolic and vascular disorders. WT and globally deleted A2(-/-) or A1(+/-) mice were fed either a high fat/high sucrose (HFHS) diet or normal diet (ND) for 16 weeks. Increases in body and VAT weight of HFHS-fed WT mice were abrogated in A2-/-, but not A1+/-, mice. Additionally, A2-/- HFHS-fed mice exhibited higher energy expenditure, lower blood glucose, and insulin levels compared to WT HFHS mice. VAT and adipocytes from WT HFHS fed mice showed greater A2 expression and adipocyte size and reduced expression of PGC-1alpha, PPAR-gamma, and adiponectin. A2 deletion blunted these effects, increased levels of active AMPK-alpha, and upregulated genes involved in fatty acid metabolism. A2 deletion prevented HFHS-induced VAT collagen deposition and inflammation, which are involved in adipocyte metabolic dysfunction. Endothelium-dependent vasorelaxation, impaired by HFHS diet, was significantly preserved in A2-/- mice, but more prominently maintained in A1+/- mice. In summary, A2 is critically involved in HFHS-induced VAT inflammation and metabolic dysfunction.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids). 57-50-1 (Sucrose). EC 3-5-3-1 (Arginase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20061462
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Atawia&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Role+of+Arginase+2+in+Systemic+Metabolic+Activity+and+Adipose+Tissue+Fatty+Acid+Metabolism+in+Diet-Induced+Obese+Mice.&volume=20&issue=6&spage=1462&epage=&date=2019&doi=10.3390%2Fijms20061462&pmid=30909461&sid=OVID:medline
+
+<1729>
+Unique Identifier
+ 30904905
+Title
+ The Bone Markers Sclerostin, Osteoprotegerin, and Bone-Specific Alkaline Phosphatase Are Related to Insulin Resistance in Children and Adolescents, Independent of Their Association with Growth and Obesity.
+Source
+ Hormone research in paediatrics. 91(1):1-8, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stanik J; Kratzsch J; Landgraf K; Vogel M; Thiery J; Kiess W; Korner A
+Authors Full Name
+ Stanik, Juraj; Kratzsch, Jurgen; Landgraf, Kathrin; Vogel, Mandy; Thiery, Joachim; Kiess, Wieland; Korner, Antje.
+Institution
+ Stanik, Juraj. Center for Pediatric Research Leipzig, Hospital for Children & Adolescents, University of Leipzig, Leipzig, Germany.
+ Stanik, Juraj. Department of Pediatrics, Medical Faculty at the Comenius University, Bratislava, Slovakia.
+ Stanik, Juraj. DIABGENE Laboratory, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Kratzsch, Jurgen. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
+ Landgraf, Kathrin. Center for Pediatric Research Leipzig, Hospital for Children & Adolescents, University of Leipzig, Leipzig, Germany.
+ Landgraf, Kathrin. Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany.
+ Vogel, Mandy. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
+ Thiery, Joachim. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
+ Kiess, Wieland. Center for Pediatric Research Leipzig, Hospital for Children & Adolescents, University of Leipzig, Leipzig, Germany.
+ Kiess, Wieland. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
+ Korner, Antje. Center for Pediatric Research Leipzig, Hospital for Children & Adolescents, University of Leipzig, Leipzig, Germany, Antje.Koerner@medizin.uni-leipzig.de.
+ Korner, Antje. Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany, Antje.Koerner@medizin.uni-leipzig.de.
+ Korner, Antje. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany, Antje.Koerner@medizin.uni-leipzig.de.
+MeSH Subject Headings
+ Adaptor Proteins, Signal Transducing
+ Adolescent
+ *Adolescent Development
+ *Alkaline Phosphatase/bl [Blood]
+ Biomarkers/bl [Blood]
+ *Bone Morphogenetic Proteins/bl [Blood]
+ Child
+ *Child Development
+ Child, Preschool
+ Female
+ Genetic Markers
+ Humans
+ Infant
+ *Insulin Resistance
+ Male
+ *Obesity/bl [Blood]
+ *Osteoprotegerin/bl [Blood]
+Keyword Heading
+ Bone-specific alkaline phosphatase
+ Children
+ Growth
+ Insulin resistance
+ Obesity
+ Osteoprotegerin
+ Sclerostin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND/AIMS: Sclerostin, osteoprotegerin, and bone-specific alkaline phosphatase (B-ALP), which are primarily related to bone metabolism, have been linked with insulin resistance in adults. We aimed to evaluate the association of these markers with growth, obesity, and parameters of insulin resistance in lean and obese children and adolescents.
+
+ METHODS: We measured sclerostin, osteoprotegerin, and B-ALP in fasting and oral glucose tolerance test (oGTT) serum samples from 1,325 children and adolescents, and during 24-h profiles and after exercise and glucose exposure in young adults.
+
+ RESULTS: In addition to the positive relationship with height standard deviation scores (SDS), sclerostin (r = 0.035, p < 0.001) and B-ALP (r = 0.06, p = 0.028) increased, whereas osteoprotegerin (r = -0.098, p < 0.001) decreased with BMI SDS. Furthermore, B-ALP correlated with fasting- and oGTT-derived markers of glucose and insulin metabolism suggestive of insulin resistance. To evaluate potential confounding diurnal variation of bone markers, we performed 24-h profiles. B-ALP and osteoprotegerin had lower night-time levels. Exercise acutely and transiently increased B-ALP and osteoprotegerin levels, but glucose ingestion had no effect.
+
+ CONCLUSIONS: Besides their association with growth, sclerostin and osteoprotegerin levels are altered in childhood obesity. Particularly B-ALP was related to insulin resistance indices. Our findings accent the link between bone, growth, and insulin resistance. Copyright © 2019 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Adaptor Proteins, Signal Transducing). 0 (Biomarkers). 0 (Bone Morphogenetic Proteins). 0 (Genetic Markers). 0 (Osteoprotegerin). 0 (SOST protein, human). 0 (TNFRSF11B protein, human). EC 3-1-3-1 (Alkaline Phosphatase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1159%2f000497113
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stanik&issn=1663-2818&title=Hormone+research+in+paediatrics&atitle=The+Bone+Markers+Sclerostin%2C+Osteoprotegerin%2C+and+Bone-Specific+Alkaline+Phosphatase+Are+Related+to+Insulin+Resistance+in+Children+and+Adolescents%2C+Independent+of+Their+Association+with+Growth+and+Obesity.&volume=91&issue=1&spage=1&epage=8&date=2019&doi=10.1159%2F000497113&pmid=30904905&sid=OVID:medline
+
+<1730>
+Unique Identifier
+ 30904536
+Title
+ Association of SNP rs7181866 in the nuclear respiratory factor-2 beta subunit encoding GABPB1 gene with obesity and type-2 diabetes mellitus in South Indian population.
+Source
+ International Journal of Biological Macromolecules. 132:606-614, 2019 Jul 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Umapathy D; Balashanmugam P; Vanniya Subramanyam P; Rajan T; Natarajan P; Krishnamoorthy E; Viswanathan V; Kunka Mohanram R
+Authors Full Name
+ Umapathy, Dhamodharan; Balashanmugam, Ponjayanthi; Vanniya Subramanyam, Paridhy; Rajan, Teena; Natarajan, Purushothaman; Krishnamoorthy, Ezhilarasi; Viswanathan, Vijay; Kunka Mohanram, Ramkumar.
+Institution
+ Umapathy, Dhamodharan. Life Science Division, SRM Research Institute, SRM Institute of Science & Technology, Kattankulathur 603 203, Tamilnadu, India.
+ Balashanmugam, Ponjayanthi. Life Science Division, SRM Research Institute, SRM Institute of Science & Technology, Kattankulathur 603 203, Tamilnadu, India.
+ Vanniya Subramanyam, Paridhy. Department of Genetics, Dr. ALM PG Institute of Basic Medical Science, University of Madras, Tamilnadu, India.
+ Rajan, Teena. Department of Biotechnology & Department of Genetic Engineering, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science & Technology, Kattankulathur 603 203, Tamilnadu, India.
+ Natarajan, Purushothaman. Department of Biotechnology & Department of Genetic Engineering, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science & Technology, Kattankulathur 603 203, Tamilnadu, India.
+ Krishnamoorthy, Ezhilarasi. Department of Biochemistry and Molecular Genetics, Prof. M. Viswanathan Diabetes Research Centre and M.V. Hospital for Diabetes (A WHO Collaborating Centre for Research, Education & Training in Diabetes), International Diabetes Federation, Centre of Education and Centre of Excellence in Diabetes Care, Royapuram, Chennai 600 013, Tamilnadu, India.
+ Viswanathan, Vijay. Department of Biochemistry and Molecular Genetics, Prof. M. Viswanathan Diabetes Research Centre and M.V. Hospital for Diabetes (A WHO Collaborating Centre for Research, Education & Training in Diabetes), International Diabetes Federation, Centre of Education and Centre of Excellence in Diabetes Care, Royapuram, Chennai 600 013, Tamilnadu, India. Electronic address: drvijay@mvdiabetes.com.
+ Kunka Mohanram, Ramkumar. Life Science Division, SRM Research Institute, SRM Institute of Science & Technology, Kattankulathur 603 203, Tamilnadu, India; Department of Biotechnology & Department of Genetic Engineering, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science & Technology, Kattankulathur 603 203, Tamilnadu, India. Electronic address: ramkumar.km@res.srmuniv.ac.in.
+MeSH Subject Headings
+ Adipokines/bl [Blood]
+ Base Sequence
+ Biomarkers/bl [Blood]
+ Cohort Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/ge [Genetics]
+ Female
+ *GA-Binding Protein Transcription Factor/ge [Genetics]
+ Genetic Predisposition to Disease/ge [Genetics]
+ Humans
+ India
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ *Polymorphism, Single Nucleotide
+Abstract
+ GABPB1, known as nuclear respiratory factor 2 (Nrf2), activates mitochondrial genes that are responsible for oxidative phosphorylation. Earlier studies on GABPB1 reported that two single nucleotide polymorphisms (SNPs) such as rs7181866 and rs8031031, to be associated with increased endurance in athletes. In the present study, a cohort of 302 South Indians, including normoglycemic healthy controls, T2DM with and without obesity were genotyped for the two SNPs by PCR-RFLP method and correlated with serum adipokines. The 'G' allele of rs7181866 was found to be associated with obesity whereas rs8031031 didn't show any significant association with obese individuals. The increased levels of adipokines such as Leptin, IL-6 and TNF-alpha and decreased adiponectin were found among obese-T2DM, when compared to non-obese T2DM subjects. Further, Factor analysis on metabolic components revealed four factors which accounts for 71.5% for non-obese control and 88.3% for obese T2DM of variance. The bias-corrected and accelerated bootstrap analysis revealed GG genotype to have significant positive and negative correlation with both TNF-alpha and adiponectin. In conclusion, the G allele of (rs7181866 A/G) was found to be significantly associated with risk for obesity among T2DM subjects. Copyright © 2019. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (GA-Binding Protein Transcription Factor). 0 (GABPB1 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ijbiomac.2019.03.125
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Umapathy&issn=0141-8130&title=International+Journal+of+Biological+Macromolecules&atitle=Association+of+SNP+rs7181866+in+the+nuclear+respiratory+factor-2+beta+subunit+encoding+GABPB1+gene+with+obesity+and+type-2+diabetes+mellitus+in+South+Indian+population.&volume=132&issue=&spage=606&epage=614&date=2019&doi=10.1016%2Fj.ijbiomac.2019.03.125&pmid=30904536&sid=OVID:medline
+
+<1731>
+Unique Identifier
+ 30904012
+Title
+ Relationship between steroid hormones and metabolic profile in women with polycystic ovary syndrome.
+Source
+ Physiological Research. 68(3):457-465, 2019 06 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lazurova I; Lazurova Z; Figurova J; Ujhazi S; Dravecka I; Maslankova J; Marekova M
+Authors Full Name
+ Lazurova, I; Lazurova, Z; Figurova, J; Ujhazi, S; Dravecka, I; Maslankova, J; Marekova, M.
+Institution
+ Lazurova, I. First Department of Internal Medicine, Medical Faculty of P.J. Safarik University Kosice, Kosice, Slovakia. ivica.lazurova@upjs.sk.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ Female
+ *Gonadal Steroid Hormones/bl [Blood]
+ Humans
+ Insulin Resistance/ph [Physiology]
+ *Metabolome/ph [Physiology]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ Polycystic Ovary Syndrome/ep [Epidemiology]
+ Young Adult
+Abstract
+ Polycystic ovary syndrome (PCOS) is commonly associated with a higher cardiometabolic risk. The relationship between steroid hormones and cardiometabolic profile in PCOS has been evaluated, but no single hormonal predictor of this association has been identified to determine. To determine the relationship between steroid hormones and cardiometabolic risk factors in PCOS women. Study included 64 women diagnosed with PCOS. Fasting blood samples were analyzed for biochemical, metabolic parameters and sex steroid hormones. PCOS women with BMI>/-27 had significantly higher serum free testosterone (FT), free androgen index (FAI), estrone (E1) (p=0.014, p=0.02, p=0.01) than those with normal weight. In all subjects E1 positively correlated with BMI (p=0.0067), serum insulin (p=0.0046), HOMA-IR (p=0.0125) and negatively with HDL-cholesterol (p=0.009). FAI positively correlated with serum cholesterol (p=0.0457), triacylglycerols (TAG) (p=0.0001), HOMA-IR (p=0.037), and glycemia (p=0.0001), negatively with HDL-cholesterol (p=0.029). In multiple linear regression model E1 most significantly predicted HOMA-IR, whereas FT/FAI predicted HDL-cholesterol and BMI. We conclude that PCOS women with marked overweight or obesity have higher FT, FAI and E1 as compared with nonobese PCOS subjects. E1 and FT may predict worse cardiometabolic profile in PCOS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Gonadal Steroid Hormones).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.33549%2fphysiolres.934062
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lazurova&issn=0862-8408&title=Physiological+Research&atitle=Relationship+between+steroid+hormones+and+metabolic+profile+in+women+with+polycystic+ovary+syndrome.&volume=68&issue=3&spage=457&epage=465&date=2019&doi=10.33549%2Fphysiolres.934062&pmid=30904012&sid=OVID:medline
+
+<1732>
+Unique Identifier
+ 30903794
+Title
+ Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging.
+Source
+ Aging. 11(6):1648-1663, 2019 03 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Scavello F; Zeni F; Tedesco CC; Mensa E; Veglia F; Procopio AD; Bonfigli AR; Olivieri F; Raucci A
+Authors Full Name
+ Scavello, Francesco; Zeni, Filippo; Tedesco, Calogero C; Mensa, Emanuela; Veglia, Fabrizio; Procopio, Antonio Domenico; Bonfigli, Anna Rita; Olivieri, Fabiola; Raucci, Angela.
+Institution
+ Scavello, Francesco. Unit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
+ Zeni, Filippo. Unit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
+ Tedesco, Calogero C. Unit of Biostatistics, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
+ Mensa, Emanuela. Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Ancona, Italy.
+ Veglia, Fabrizio. Unit of Biostatistics, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
+ Procopio, Antonio Domenico. Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Ancona, Italy.
+ Procopio, Antonio Domenico. Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
+ Bonfigli, Anna Rita. Scientific Direction, IRCCS INRCA, Ancona, Italy.
+ Olivieri, Fabiola. Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Ancona, Italy.
+ Olivieri, Fabiola. Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
+ Raucci, Angela. Unit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Female
+ *Healthy Aging/ge [Genetics]
+ Humans
+ Insulin Resistance/ge [Genetics]
+ Ligands
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Protein Isoforms/bl [Blood]
+ *Receptor for Advanced Glycation End Products/bl [Blood]
+ Receptor for Advanced Glycation End Products/cl [Classification]
+ Receptor for Advanced Glycation End Products/ge [Genetics]
+ Risk Factors
+ Young Adult
+Keyword Heading
+ RAGE isoforms
+ aging
+ biomarker
+ cardiovascular risk
+ inflammaging
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The receptor for advanced glycation end-products (RAGE) recognizes several ligands involved in inflammatory diseases. Two circulating soluble isoforms exist: esRAGE derived from alternative splicing and cRAGE generated by the membrane-bound RAGE (FL-RAGE) proteolysis. Together, esRAGE and cRAGE constitute sRAGE and function as decoy receptors preventing FL-RAGE/ligands binding. We determined serum concentration of both, esRAGE and cRAGE, and their ligands AGEs, HMGB1 and S100A8/A9 in a healthy population of 169 subjects aged 20-90 years. cRAGE showed a negative (r=-0.375, P<0.0001) while AGEs (r=0.160, P=0.0384) and S100A8/A9 (r=0.207, P=0.0091) a positive correlation with age. esRAGE did not change during aging and inversely correlated with Hemoglobin, ALT, insulin, HOMA index, Waist-Hip ratio (W/H), Waist Circumference (WC) and positively with AGEs. cRAGE exhibited also an inverse correlation with WC, W/H, PAI-1, HMGB1, AGEs and S100A8/A9. Age, W/H, HMGB1, S100A8/A9 and AGEs are independent predictors of cRAGE, whereas W/H and AGEs associate with esRAGE. Treatment of cells with glycated albumin reduced cRAGE production and upregulated FL-RAGE. These results indicate that in a healthy population cRAGE is a biomarker of aging while esRAGE represents a more reliable marker of obesity and insulin resistance. Hence, sRAGE isoforms levels could be differentially associated with age-related diseases risk factors.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ligands). 0 (Protein Isoforms). 0 (Receptor for Advanced Glycation End Products).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.18632%2faging.101860
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Scavello&issn=1945-4589&title=Aging&atitle=Modulation+of+soluble+receptor+for+advanced+glycation+end-products+%28RAGE%29+isoforms+and+their+ligands+in+healthy+aging.&volume=11&issue=6&spage=1648&epage=1663&date=2019&doi=10.18632%2Faging.101860&pmid=30903794&sid=OVID:medline
+
+<1733>
+Unique Identifier
+ 30903169
+Title
+ Pancreatic AT1aR Deficiency Decreases Insulin Secretion in Obese C57BL/6 Mice.
+Source
+ American Journal of Hypertension. 32(6):597-604, 2019 05 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shoemaker R; AlSiraj Y; Chen J; Cassis LA
+Authors Full Name
+ Shoemaker, Robin; AlSiraj, Yasir; Chen, Jeff; Cassis, Lisa A.
+Institution
+ Shoemaker, Robin. Department of Dietetics and Human Nutrition, University of Kentucky, Lexington, Kentucky, USA.
+ AlSiraj, Yasir. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
+ Chen, Jeff. Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
+ Cassis, Lisa A. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
+MeSH Subject Headings
+ Adaptation, Physiological
+ Angiotensin II/ad [Administration & Dosage]
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Diet, Fat-Restricted
+ *Diet, High-Fat
+ Disease Models, Animal
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ Islets of Langerhans/de [Drug Effects]
+ *Islets of Langerhans/me [Metabolism]
+ Islets of Langerhans/pp [Physiopathology]
+ Male
+ Mice, Inbred C57BL
+ Mice, Knockout
+ *Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ *Receptor, Angiotensin, Type 1/df [Deficiency]
+ Receptor, Angiotensin, Type 1/ge [Genetics]
+ Renin-Angiotensin System/de [Drug Effects]
+ *Renin-Angiotensin System
+ Secretory Pathway
+Keyword Heading
+ AT1R
+ angiotensin
+ blood pressure
+ diabetes
+ hypertension
+ insulin
+ islets
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Previously, we demonstrated that obese mice have marked elevations in systemic concentrations of angiotensin II (AngII). Drugs that inhibit the renin-angiotensin system (RAS), including angiotensin type 1 receptor (AT1R) antagonists, have been reported to delay the onset of type 2 diabetes (T2D), suggesting improvements in insulin sensitivity or regulation of pancreatic insulin secretion. Pancreatic islets possess components of the RAS, including AT1R, but it is unclear if AngII acts at islets to regulate insulin secretion during the development of T2D.
+
+ METHODS: We deleted AT1aR from pancreatic islets and examined effects on insulin secretion in mice fed a low-fat (LF) or high-fat (HF) diet. In separate studies, to exacerbate the system, we infused HF-fed mice of each genotype with AngII.
+
+ RESULTS: Pancreatic AT1aR deficiency impaired glucose tolerance and elevated plasma glucose concentrations in HF, but not LF-fed mice. In HF-fed mice, high glucose increased insulin secretion from islets of AT1aRfl/fl, but not AT1aRpdx mice. In AngII-infused mice, following glucose challenge, plasma glucose or insulin concentrations were not significantly different between genotypes. Moreover, high glucose stimulated insulin secretion from islets of AT1aRfl/fl and AT1aRpdx mice, presumably related to weight loss, and improved insulin sensitivity in both groups of AngII-infused HF-fed mice.
+
+ CONCLUSIONS: Our results suggest that during the adaptive response to insulin resistance from HF feeding, AngII promotes insulin secretion from islets through an AT1aR mechanism. These results suggest the timing of initiation of AT1R blockade may be important in the progression from prediabetes to T2D with beta-cell failure. Copyright © American Journal of Hypertension, Ltd 2019. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Agtr1a protein, mouse). 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Receptor, Angiotensin, Type 1). 11128-99-7 (Angiotensin II).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fajh%2fhpz042
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shoemaker&issn=0895-7061&title=American+Journal+of+Hypertension&atitle=Pancreatic+AT1aR+Deficiency+Decreases+Insulin+Secretion+in+Obese+C57BL%2F6+Mice.&volume=32&issue=6&spage=597&epage=604&date=2019&doi=10.1093%2Fajh%2Fhpz042&pmid=30903169&sid=OVID:medline
+
+<1734>
+Unique Identifier
+ 30902758
+Title
+ Lipidomic methodologies for biomarkers of chronic inflammation in nutritional research: omega-3 and omega-6 lipid mediators. [Review]
+Source
+ Free Radical Biology & Medicine. 144:90-109, 2019 11 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dasilva G; Medina I
+Authors Full Name
+ Dasilva, Gabriel; Medina, Isabel.
+Institution
+ Dasilva, Gabriel. Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Cientificas (IIM-CSIC), c/Eduardo Cabello 6, 36208, Vigo, Spain. Electronic address: gabrieldasilvaalonso@gmail.com.
+ Medina, Isabel. Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Cientificas (IIM-CSIC), c/Eduardo Cabello 6, 36208, Vigo, Spain.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/dh [Diet Therapy]
+ *Cardiovascular Diseases/me [Metabolism]
+ Cardiovascular Diseases/pp [Physiopathology]
+ Chromatography, Liquid
+ Diet/mt [Methods]
+ Dietary Fats/ad [Administration & Dosage]
+ Dietary Fats/me [Metabolism]
+ Fatty Acids, Omega-3/ad [Administration & Dosage]
+ Fatty Acids, Omega-3/ch [Chemistry]
+ *Fatty Acids, Omega-3/me [Metabolism]
+ Fatty Acids, Omega-6/ad [Administration & Dosage]
+ Fatty Acids, Omega-6/ch [Chemistry]
+ *Fatty Acids, Omega-6/me [Metabolism]
+ Humans
+ Inflammation
+ Isoprostanes/an [Analysis]
+ Isoprostanes/ch [Chemistry]
+ Isoprostanes/me [Metabolism]
+ Lipid Peroxides/an [Analysis]
+ Lipid Peroxides/ch [Chemistry]
+ Lipid Peroxides/me [Metabolism]
+ Lipidomics/is [Instrumentation]
+ *Lipidomics/mt [Methods]
+ Mass Spectrometry
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/dh [Diet Therapy]
+ *Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/di [Diagnosis]
+ Obesity/dh [Diet Therapy]
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Prostaglandins/an [Analysis]
+ Prostaglandins/ch [Chemistry]
+ Prostaglandins/me [Metabolism]
+ Thromboxanes/an [Analysis]
+ Thromboxanes/ch [Chemistry]
+ Thromboxanes/me [Metabolism]
+Abstract
+ The evolutionary history of hominins has been characterized by significant dietary changes, which include the introduction of meat eating, cooking, and the changes associated with plant and animal domestication. The Western pattern diet has been linked with the onset of chronic inflammation, and serious health problems including obesity, metabolic syndrome, and cardiovascular diseases. Diets enriched with omega-3 marine PUFAs have revealed additional improvements in health status associated to a reduction of proinflammatory omega-3 and omega-6 lipid mediators. Lipid mediators are produced from enzymatic and non-enzymatic oxidation of PUFAs. Interest in better understanding the occurrence of these metabolites has increased exponentially as a result of the growing evidence of their role on inflammatory processes, control of the immune system, cell signaling, onset of metabolic diseases, or even cancer. The scope of this review has been to highlight the recent findings on: a) the formation of lipid mediators and their role in different inflammatory and metabolic conditions, b) the direct use of lipid mediators as antiinflammatory drugs or the potential of new drugs as a new therapeutic option for the synthesis of antiinflammatory or resolving lipid mediators and c) the impact of nutritional interventions to modulate lipid mediators synthesis towards antiinflammatory conditions. In a second part, we have summarized methodological approaches (Lipidomics) for the accurate analysis of lipid mediators. Although several techniques have been used, most authors preferred the combination of SPE with LC-MS. Advantages and disadvantages of each method are herein addressed, as well as the main LC-MS difficulties and challenges for the establishment of new biomarkers and standardization of experimental designs, and finally to deepen the study of mechanisms involved on the inflammatory response. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fats). 0 (Fatty Acids, Omega-3). 0 (Fatty Acids, Omega-6). 0 (Isoprostanes). 0 (Lipid Peroxides). 0 (Prostaglandins). 0 (Thromboxanes).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.freeradbiomed.2019.03.017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dasilva&issn=0891-5849&title=Free+Radical+Biology+%26+Medicine&atitle=Lipidomic+methodologies+for+biomarkers+of+chronic+inflammation+in+nutritional+research%3A+omega-3+and+omega-6+lipid+mediators.&volume=144&issue=&spage=90&epage=109&date=2019&doi=10.1016%2Fj.freeradbiomed.2019.03.017&pmid=30902758&sid=OVID:medline
+
+<1735>
+Unique Identifier
+ 30898807
+Title
+ Obesity and recovery from acute kidney injury (Ob AKI): a prospective cohort feasibility study.
+Source
+ BMJ Open. 9(3):e024033, 2019 03 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ MacLaughlin HL; Blacklock RM; Wright K; Pot G; Jayawardene S; McIntyre CW; Macdougall IC; Selby NM
+Author NameID
+ MacLaughlin, Helen L; ORCID: https://orcid.org/0000-0001-9617-546X
+ Selby, Nicholas M; ORCID: https://orcid.org/0000-0003-0351-8326
+Authors Full Name
+ MacLaughlin, Helen L; Blacklock, Rochelle M; Wright, Kelly; Pot, Gerda; Jayawardene, Satish; McIntyre, Christopher W; Macdougall, Iain C; Selby, Nicholas M.
+Institution
+ MacLaughlin, Helen L. Department of Nutrition and Dietetics, King's College Hospital NHS Foundation Trust, London, UK.
+ MacLaughlin, Helen L. Department of Nutritional Sciences, King's College London, London, UK.
+ Blacklock, Rochelle M. Department of Nutrition and Dietetics, King's College Hospital NHS Foundation Trust, London, UK.
+ Blacklock, Rochelle M. Department of Nutritional Sciences, King's College London, London, UK.
+ Wright, Kelly. Department of Renal Medicine, King's College Hospital NHS Foundation Trust, London, UK.
+ Pot, Gerda. Department of Nutritional Sciences, King's College London, London, UK.
+ Jayawardene, Satish. Department of Renal Medicine, King's College Hospital NHS Foundation Trust, London, UK.
+ McIntyre, Christopher W. Division of Nephrology, University of Western Ontario, Ontario, UK.
+ Macdougall, Iain C. Department of Renal Medicine, King's College Hospital NHS Foundation Trust, London, UK.
+ Selby, Nicholas M. Centre for Kidney Research and Innovation, University of Nottingham Faculty of Medicine and Health Sciences, Derby, UK.
+ Selby, Nicholas M. Department of Renal Medicine, Royal Derby Hospital, Derby, UK.
+MeSH Subject Headings
+ *Acute Kidney Injury/pp [Physiopathology]
+ Aged
+ Biomarkers
+ Cystatin C/me [Metabolism]
+ Disease Progression
+ Feasibility Studies
+ Female
+ Glomerular Filtration Rate
+ Humans
+ Interleukin-6/me [Metabolism]
+ London
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Observational Studies as Topic
+ Prospective Studies
+ Renal Insufficiency, Chronic/pp [Physiopathology]
+Keyword Heading
+ acute renal failure
+ chronic renal failure
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To test the methodology of recruitment, retention and data completeness in a prospective cohort recruited after a hospitalised episode of acute kidney injury (AKI), to inform a future prospective cohort study examining the effect of obesity on AKI outcomes.
+
+ DESIGN: Feasibility study.
+
+ SETTING: Single centre, multi-site UK tertiary hospital.
+
+ PARTICIPANTS: 101 participants (67M; 34F) with a median age of 64 (IQR 53-73) years, with and without obesity, recruited within 3 months of a hospitalised episode of AKI.
+
+ OUTCOME MEASURES: Feasibility outcomes were recruitment (>15% meeting inclusion criteria recruited), participant retention at 6 and 12 months (>=80%) and completeness of data collection. Exploratory measures included recovery from AKI (regaining >75% of pre-AKI estimated glomerular filtration rate [eGFR]) at 6 months, development or progression of chronic kidney disease (CKD) (kidney function decrease of >=25% + rise in CKD category) at 12 months, and associations with poorer kidney outcomes.
+
+ RESULTS: 41% of eligible patients consented to take part, exceeding the target recruitment uptake rate of 15%. Retention was 86% at 6 months and 78% at 12 months; 10 patients died and three commenced dialysis during the study. Data were 90%-100% complete. Median BMI was 27.9 kg/m2 (range 18.1 kg/m2-54.3 kg/m2). 50% of the cohort had stage 3 AKI and 49% had pre-existing CKD. 46% of the cohort met the AKI recovery definition at 6 months. At 12 months, 20/51 patients developed CKD (39%) and CKD progression occurred in 11/49 patients (22%). Post-AKI interleukin-6 and cystatin-C were associated with 12 months decline in eGFR.
+
+ CONCLUSIONS: Feasibility to conduct a long-term observational study addressing AKI outcomes associated with obesity was demonstrated. A fully powered prospective cohort study to examine the relationships between obesity and outcomes of AKI is warranted. Copyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cystatin C). 0 (Interleukin-6).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1136%2fbmjopen-2018-024033
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=MacLaughlin&issn=2044-6055&title=BMJ+Open&atitle=Obesity+and+recovery+from+acute+kidney+injury+%28Ob+AKI%29%3A+a+prospective+cohort+feasibility+study.&volume=9&issue=3&spage=e024033&epage=&date=2019&doi=10.1136%2Fbmjopen-2018-024033&pmid=30898807&sid=OVID:medline
+
+<1736>
+Unique Identifier
+ 30892820
+Title
+ Independent markers of nonalcoholic fatty liver disease in a gentrifying population-based Chinese cohort.
+Source
+ Diabetes/Metabolism Research Reviews. 35(5):e3156, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhou X; Li Y; Zhang X; Guan YY; Puentes Y; Zhang F; Speliotes EK; Ji L
+Author NameID
+ Ji, Linong; ORCID: https://orcid.org/0000-0002-3262-2168
+Authors Full Name
+ Zhou, Xianghai; Li, Yufeng; Zhang, Xiuying; Guan, Ying Ying; Puentes, Yindra; Zhang, Fang; Speliotes, Elizabeth K; Ji, Linong.
+Institution
+ Zhou, Xianghai. Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.
+ Li, Yufeng. Department of Endocrinology and Metabolism, Pinggu Hospital, Beijing, China.
+ Zhang, Xiuying. Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.
+ Guan, Ying Ying. Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan.
+ Puentes, Yindra. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan.
+ Zhang, Fang. Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.
+ Speliotes, Elizabeth K. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan.
+ Speliotes, Elizabeth K. Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
+ Ji, Linong. Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.
+MeSH Subject Headings
+ Adult
+ Aged
+ Asian People/sn [Statistics & Numerical Data]
+ Biomarkers/an [Analysis]
+ *Biomarkers/bl [Blood]
+ China/ep [Epidemiology]
+ Cluster Analysis
+ Cohort Studies
+ Female
+ Humans
+ *Life Style
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ *Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Nutrition Surveys
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Red Meat/sn [Statistics & Numerical Data]
+ Risk Factors
+ Urbanization/td [Trends]
+ *Urbanization
+Keyword Heading
+ diabetes
+ nonalcoholic fatty liver disease
+ obesity
+ physical activity
+ red meat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China.
+
+ METHODS: We randomized cluster sampled 4002 Pinggu residents aged 26 to 76 years. Data from 1238 men and 1928 women without significant alcohol drinking or hepatitis virus B or C infection were analysed. NAFLD was defined using a liver-spleen ratio (L/S ratio) <=1.1 on unenhanced abdominal computed tomography (CT) scanning.
+
+ RESULTS: Of men and women, 26.5% and 20.1%, respectively, had NAFLD. NAFLD prevalence was highest in younger men and older women. In multivariate logistic regression models, higher body mass index, waist circumference, serum triglyceride, alanine transaminase, and haemoglobin A1c independently increased the odds of NAFLD in both men and women separately. Higher annual household income and systolic blood pressure for men and higher serum uric acid and red meat intake and lower physical activity levels for women also independently associated with higher odds of NAFLD. Individuals with L/S ratio <=1.1 had linearly increasing rates of obesity, diabetes, and metabolic syndrome that paralleled fatty liver increase.
+
+ CONCLUSIONS: NAFLD is common in a gentrifying Chinese population particularly in younger men of high socioeconomic status and older women with sedentary behaviour who eat red meat. Demographic factors add independent risk of NAFLD above traditional metabolic risk factors. A CT L/S ratio of <=1.1 identifies individuals at high risk of metabolic disease. Copyright © 2019 John Wiley & Sons, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fdmrr.3156
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhou&issn=1520-7552&title=Diabetes%2FMetabolism+Research+Reviews&atitle=Independent+markers+of+nonalcoholic+fatty+liver+disease+in+a+gentrifying+population-based+Chinese+cohort.&volume=35&issue=5&spage=e3156&epage=&date=2019&doi=10.1002%2Fdmrr.3156&pmid=30892820&sid=OVID:medline
+
+<1737>
+Unique Identifier
+ 30889454
+Title
+ Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trial.
+Source
+ Nutrition. 62:135-139, 2019 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Campbell MS; Ouyang A; I M K; Charnigo RJ; Westgate PM; Fleenor BS
+Authors Full Name
+ Campbell, Marilyn S; Ouyang, An; I M, Krishnakumar; Charnigo, Richard J; Westgate, Philip M; Fleenor, Bradley S.
+Institution
+ Campbell, Marilyn S. Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, Kentucky 40506, USA.
+ Ouyang, An. Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, Kentucky 40506, USA.
+ I M, Krishnakumar. Akay Flavours & Aromatics Pvt. Ltd., R&D Centre, Ambunadu, Malayidamthuruthu P.O., Cochin 683561, India.
+ Charnigo, Richard J. Department of Biostatistics, University of Kentucky, Lexington, Kentucky 40536, USA.
+ Westgate, Philip M. Department of Biostatistics, University of Kentucky, Lexington, Kentucky 40536, USA.
+ Fleenor, Bradley S. Human Performance Laboratory, Ball State University, Muncie, Indiana 47306, USA. Electronic address: Bsfleenor@bsu.edu.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Anti-Inflammatory Agents, Non-Steroidal/ad [Administration & Dosage]
+ Anti-Inflammatory Agents, Non-Steroidal/bl [Blood]
+ Anti-Inflammatory Agents, Non-Steroidal/pd [Pharmacology]
+ Arteries/de [Drug Effects]
+ Arteries/ph [Physiology]
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases/co [Complications]
+ Curcumin/ad [Administration & Dosage]
+ Curcumin/me [Metabolism]
+ *Curcumin/pd [Pharmacology]
+ Dietary Supplements
+ Double-Blind Method
+ *Endothelium, Vascular/de [Drug Effects]
+ *Endothelium, Vascular/ph [Physiology]
+ Homocysteine/bl [Blood]
+ Homocysteine/de [Drug Effects]
+ Humans
+ Lipoproteins/bl [Blood]
+ Lipoproteins/de [Drug Effects]
+ Male
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Risk Factors
+ Young Adult
+Keyword Heading
+ Turmeric
+ adiposity
+ arteriosclerosis
+ intervention
+ vascular function
+ vasodilation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: This study aimed to determine whether an enhanced bioavailable curcumin formulation, CurQfen R, would improve circulating cardiovascular disease-related blood biomarkers and arterial function in young (age 18-35 y), obese (body mass index >= 30.0 kg/m2) men.
+
+ METHODS: This double-blinded, placebo-controlled trial evaluated 22 men. The participants were matched based on body mass index and randomized to the intervention (curcumin formulated with fenugreek soluble fiber, for enhanced absorption) or control (fenugreek soluble fiber) group for 12 wk at 500mg/d without dietary modification or exercise. Blood samples and endothelial function measures were acquired at 0 and 12 wk, and blood samples were analyzed for cardiovascular disease-related blood biomarkers. Furthermore, central (aortic) blood pressure and augmentation index were monitored at 0, 4, 8, and 12 wk.
+
+ RESULTS: After 12 wk of intervention, homocysteine levels were lower (curcumin before: 12.22 +/- 2.29 microg/mL, after: 8.62 +/- 1.02 microg/mL versus placebo before: 9.45 +/- 0.84 microg/mL, after: 11.84 +/- 1.63 microg/mL; P=0.04) and high-density lipoprotein levels were higher (curcumin before: 40.77 +/- 5.37 mg/dL, after: 54.56 +/- 11.72 mg/dL versus placebo before: 61.20 +/- 5.76 mg/dL, after: 48.82 +/- 5.49 mg/dL; P=0.04) in the curcumin group relative to the placebo group. However, there was no significant difference in changes between the circulating concentrations of glucose, insulin, leptin, adiponectin, or oxidative stress biomarkers in the curcumin group compared with the placebo group (P > 0.05). No changes were found with endothelial function, augmentation index, or central blood pressure in the curcumin group compared with the placebo group (P > 0.05).
+
+ CONCLUSIONS: Our data provide evidence for an enhanced bioavailable curcumin to improve homocysteine and high-density lipoprotein concentrations, which may promote favorable cardiovascular health in young, obese men. Improvements in endothelial function or blood pressure were not observed with curcumin supplementation, thus further investigation is warranted. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Anti-Inflammatory Agents, Non-Steroidal). 0 (Biomarkers). 0 (Lipoproteins). 0LVT1QZ0BA (Homocysteine). IT942ZTH98 (Curcumin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.nut.2019.01.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Campbell&issn=0899-9007&title=Nutrition&atitle=Influence+of+enhanced+bioavailable+curcumin+on+obesity-associated+cardiovascular+disease+risk+factors+and+arterial+function%3A+A+double-blinded%2C+randomized%2C+controlled+trial.&volume=62&issue=&spage=135&epage=139&date=2019&doi=10.1016%2Fj.nut.2019.01.002&pmid=30889454&sid=OVID:medline
+
+<1738>
+Unique Identifier
+ 30879171
+Title
+ The roles of FGF21 in atherosclerosis pathogenesis. [Review]
+Source
+ Reviews in Endocrine & Metabolic Disorders. 20(1):103-114, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tabari FS; Karimian A; Parsian H; Rameshknia V; Mahmoodpour A; Majidinia M; Maniati M; Yousefi B
+Author NameID
+ Yousefi, Bahman; ORCID: http://orcid.org/0000-0002-4220-1527
+Authors Full Name
+ Tabari, Farzane Shanebandpour; Karimian, Ansar; Parsian, Hadi; Rameshknia, Vahid; Mahmoodpour, Ata; Majidinia, Maryam; Maniati, Mahmood; Yousefi, Bahman.
+Institution
+ Tabari, Farzane Shanebandpour. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
+ Tabari, Farzane Shanebandpour. Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
+ Karimian, Ansar. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
+ Karimian, Ansar. Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
+ Parsian, Hadi. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
+ Rameshknia, Vahid. Faculty of Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
+ Rameshknia, Vahid. Department of Biochemistry, Baku State University, Baku, Azerbaijan.
+ Mahmoodpour, Ata. Anesthesiology Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Mahmoodpour, Ata. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Majidinia, Maryam. Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
+ Maniati, Mahmood. Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Yousefi, Bahman. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. yousefib@tbzmed.ac.ir.
+ Yousefi, Bahman. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. yousefib@tbzmed.ac.ir.
+ Yousefi, Bahman. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran. yousefib@tbzmed.ac.ir.
+MeSH Subject Headings
+ Animals
+ Atherosclerosis/me [Metabolism]
+ Atherosclerosis/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ Fibroblast Growth Factors/ge [Genetics]
+ *Fibroblast Growth Factors/me [Metabolism]
+ Humans
+ *Hypertension/me [Metabolism]
+ *Hypertension/pa [Pathology]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+Keyword Heading
+ Atherosclerosis
+ FGF21
+ Hypertension
+ Lipid
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ FGF21 is a peptide hormone that regulates homeostasis of lipid and glucose as well as energy metabolism. It is mainly expressed and secreted in liver and adipose tissues, and it is expressed in lower amounts in the aorta. Recent clinical and preclinical studies indicate increased serum FGF21 levels in atherosclerosis patients. Also, FGF21 therapy has been reported to reduce the initiation and progression of atherosclerosis in animal models and in vitro studies. Moreover, growing evidence indicates that administration of exogenous FGF21 induces anti-atherosclerotic effects, because of its ability to reduce lipid profile, alleviation of oxidative stress, inflammation, and apoptosis. Therefore, FGF21 can not only be considered as a biomarker for predicting atherosclerosis, but also induce protective effects against atherosclerosis. Besides, serum levels of FGF21 increase in various diseases including in diabetes mellitus, hypertension, and obesity, which may be related to initiating and exacerbating atherosclerosis. On the other hand, FGF21 therapy significantly improves lipid profiles, and reduces vascular inflammation and oxidative stress in atherosclerosis related diseases. Therefore, further prospective studies are needed to clarify whether FGF21 can be used as a prognostic biomarker to identify individuals at future risk of atherosclerosis in these atherosclerosis-associated diseases. In this review, we will discuss the possible mechanism by which FGF21 protects against atherosclerosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11154-019-09488-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tabari&issn=1389-9155&title=Reviews+in+Endocrine+%26+Metabolic+Disorders&atitle=The+roles+of+FGF21+in+atherosclerosis+pathogenesis.&volume=20&issue=1&spage=103&epage=114&date=2019&doi=10.1007%2Fs11154-019-09488-x&pmid=30879171&sid=OVID:medline
+
+<1739>
+Unique Identifier
+ 30878797
+Title
+ Associations of serum CRP levels with demographics, health behaviors, and risk of cancer among the Mexican American Mano A Mano Cohort.
+Source
+ Cancer Epidemiology. 60:1-7, 2019 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shen J; Hernandez D; McNeill LH; Chow WH; Zhao H
+Authors Full Name
+ Shen, Jie; Hernandez, Daphne; McNeill, Lorna Haughton; Chow, Wong-Ho; Zhao, Hua.
+Institution
+ Shen, Jie. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+ Hernandez, Daphne. Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+ McNeill, Lorna Haughton. Department of Health and Human Performance, University of Houston, TX, USA.
+ Chow, Wong-Ho. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
+ Zhao, Hua. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: hzhao2@mdanderson.org.
+MeSH Subject Headings
+ Aged
+ *Biomarkers/bl [Blood]
+ *C-Reactive Protein/an [Analysis]
+ Demography
+ Female
+ *Health Behavior
+ Humans
+ Male
+ *Mexican Americans/sn [Statistics & Numerical Data]
+ Middle Aged
+ *Neoplasms/bl [Blood]
+ Neoplasms/di [Diagnosis]
+ Neoplasms/et [Etiology]
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prospective Studies
+ Risk Factors
+Keyword Heading
+ CRP
+ Cancer risk
+ Mexican Americans
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ C-Reactive protein (CRP) is a well-known inflammatory marker, and elevated CRP levels has been reported to be associated with the risk of various cancers. To date, no study has investigated the association between elevated CRP and incidents of cancer among Mexican Americans. In the current prospective cohort study, we measured pre-diagnostic CRP levels in serum samples and evaluated their relationships with demographic characteristics and health behaviors associated with cancer risk among 2753 Mexican Americans selected from the Mano-A-Mano Mexican American Cohort Study. At baseline, median levels of serum CRP significantly differed by demographics (sex, age category, marital status, and education levels) and health behaviors (cigarette smoking status, alcohol drinking status, BMI category, and physical activity levels). In the multivariable analysis, the study participants who were women, older, never drinking alcohol, overweight or obese, and physically inactive had increased likelihood of having high CRP levels (>= median levels among all study participants) compared to their counterparts. A total of 177 cancer cases were identified during the follow-up with a median follow-up time of 127 months. In the quartile analysis, study participants in the 4th quartile with highest CRP levels had significantly 1.88 fold increased risk of cancer (hazard ratio (HR) = 1.88, 95%CI: 1.12, 3.13) compared to those in the 1st quartile with lowest CRP levels. The association was further confirmed in analyses using clinical CRP levels. In summary, our findings suggested that serum CRP levels have potential to serve as a predictive marker of cancer risk in Mexican Americans. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.canep.2019.03.001
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shen&issn=1877-7821&title=Cancer+Epidemiology&atitle=Associations+of+serum+CRP+levels+with+demographics%2C+health+behaviors%2C+and+risk+of+cancer+among+the+Mexican+American+Mano+A+Mano+Cohort.&volume=60&issue=&spage=1&epage=7&date=2019&doi=10.1016%2Fj.canep.2019.03.001&pmid=30878797&sid=OVID:medline
+
+<1740>
+Unique Identifier
+ 30877903
+Title
+ Knowing is not half the battle: Impacts of information from the National Health Screening Program in Korea.
+Source
+ Journal of Health Economics. 65:1-14, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim HB; Lee SA; Lim W
+Authors Full Name
+ Kim, Hyuncheol Bryant; Lee, Suejin A; Lim, Wilfredo.
+Institution
+ Kim, Hyuncheol Bryant. Department of Policy Analysis and Management, Cornell University, Ithaca, NY 14853, United States. Electronic address: hk788@cornell.edu.
+ Lee, Suejin A. Department of Economics, Cornell University, Ithaca, NY 14853, United States.
+ Lim, Wilfredo. Mathematica Policy Research, Oakland, CA 94612, United States.
+MeSH Subject Headings
+ Biomarkers
+ Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ Diabetes Mellitus, Type 2/px [Psychology]
+ Female
+ Health Behavior
+ Health Knowledge, Attitudes, Practice
+ Humans
+ Hyperlipidemias/pc [Prevention & Control]
+ Hyperlipidemias/px [Psychology]
+ Male
+ Mass Screening/px [Psychology]
+ Mass Screening/sn [Statistics & Numerical Data]
+ *Mass Screening
+ Middle Aged
+ Obesity/pc [Prevention & Control]
+ Obesity/px [Psychology]
+ Republic of Korea
+ *Risk Reduction Behavior
+Keyword Heading
+ Diabetes
+ Health behavior
+ Health screening
+ Hyperlipidemia
+ Information
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Health screening provides information on disease risk and diagnosis, but whether this promotes health is unclear. We estimate the impacts of information provided by Korea's National Health Screening Program by applying a regression discontinuity design around different biomarker thresholds of diabetes, obesity, and hyperlipidemia risk using administrative data that includes medical claims, biomarkers, and behavioral surveys over four years after screening. Generally, we find limited responses to disease risk information alone. However, we find evidence for weight loss around the high risk threshold for diabetes, where information is combined with active prompting for a secondary examination for diagnosis and treatment. Copyright © 2019 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.jhealeco.2019.01.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=0167-6296&title=Journal+of+Health+Economics&atitle=Knowing+is+not+half+the+battle%3A+Impacts+of+information+from+the+National+Health+Screening+Program+in+Korea.&volume=65&issue=&spage=1&epage=14&date=2019&doi=10.1016%2Fj.jhealeco.2019.01.003&pmid=30877903&sid=OVID:medline
+
+<1741>
+Unique Identifier
+ 30872696
+Title
+ Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus, and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study.
+Source
+ Scientific Reports. 9(1):4573, 2019 03 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kanmani S; Kwon M; Shin MK; Kim MK
+Author NameID
+ Kim, Mi Kyung; ORCID: https://orcid.org/0000-0001-5279-4162
+Authors Full Name
+ Kanmani, Suganya; Kwon, Minji; Shin, Moon-Kyung; Kim, Mi Kyung.
+Institution
+ Kanmani, Suganya. Division of Cancer Epidemiology and Prevention, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, South Korea.
+ Kwon, Minji. Division of Cancer Epidemiology and Prevention, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, South Korea.
+ Shin, Moon-Kyung. Division of Cancer Epidemiology and Prevention, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, South Korea.
+ Kim, Mi Kyung. Division of Cancer Epidemiology and Prevention, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, South Korea. alrud@ncc.re.kr.
+MeSH Subject Headings
+ Biomarkers
+ C-Reactive Protein/me [Metabolism]
+ *C-Reactive Protein
+ Cohort Studies
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ *Disease Susceptibility
+ Female
+ Humans
+ Hypertension/co [Complications]
+ Hypertension/ep [Epidemiology]
+ Incidence
+ Male
+ Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Population Surveillance
+ Proportional Hazards Models
+ Republic of Korea
+ Risk Factors
+Abstract
+ This study was undertaken to assess the associations of C-reactive protein (CRP) with incident type-2 diabetes mellitus (T2DM) and to determine the joint effect of obesity and hypertension on them in the large-scale population-based Korean cohort of the Korean Genome and Epidemiology study (KoGES). We included 22,946 men and women from 11 rural communities at baseline (2005-2011). Epidemiological data and blood samples were collected. Incident physician-diagnosed T2DM cases (130 men and 148 women) were self-reported or based on fasting glucose >=126 mg/dL or HbA1c level >=6.5% during a median follow-up of 3.0 years (58,916 person-years) between 2007 and 2014. After multivariate adjustment for T2DM risk factors, the hazard ratios for developing T2DM in the highest CRP tertile (T3), compared with the lowest (T1), was 2.80 (1.73-4.52; p for trend <0.0001) in women and 1.67 (1.00-2.45; p for trend 0.02) in men. The associations between CRP and incident T2DM were more prominent among the older group (>=50 years). And CRP and its combination with obesity and hypertension were associated with increased risk of T2DM. In conclusion, we found positive associations between CRP and incident T2DM in a large population-based Korean cohort.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-40987-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kanmani&issn=2045-2322&title=Scientific+Reports&atitle=Association+of+C-Reactive+Protein+with+Risk+of+Developing+Type+2+Diabetes+Mellitus%2C+and+Role+of+Obesity+and+Hypertension%3A+A+Large+Population-Based+Korean+Cohort+Study.&volume=9&issue=1&spage=4573&epage=&date=2019&doi=10.1038%2Fs41598-019-40987-8&pmid=30872696&sid=OVID:medline
+
+<1742>
+Unique Identifier
+ 30871567
+Title
+ The relationship between the mtDNA copy number in insulin-dependent tissues and markers of endothelial dysfunction and inflammation in obese patients.
+Source
+ BMC Medical Genomics [Electronic Resource]. 12(Suppl 2):41, 2019 03 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Litvinova L; Zatolokin P; Vulf M; Mazunin I; Skuratovskaia D
+Authors Full Name
+ Litvinova, Larisa; Zatolokin, Pavel; Vulf, Maria; Mazunin, Ilia; Skuratovskaia, Daria.
+Institution
+ Litvinova, Larisa. Immanuel Kant Baltic Federal University, Russian Federation, Kaliningrad, Gaidara 6 st, Russia.
+ Zatolokin, Pavel. Department of Reconstructive and Endoscopic Surgery, Kaliningrad Regional Hospital, Kaliningrad, Russia.
+ Vulf, Maria. Immanuel Kant Baltic Federal University, Russian Federation, Kaliningrad, Gaidara 6 st, Russia.
+ Mazunin, Ilia. Immanuel Kant Baltic Federal University, Russian Federation, Kaliningrad, Gaidara 6 st, Russia.
+ Skuratovskaia, Daria. Immanuel Kant Baltic Federal University, Russian Federation, Kaliningrad, Gaidara 6 st, Russia. dariask@list.ru.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ *Biomarkers/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ Cholesterol/bl [Blood]
+ DNA Copy Number Variations
+ *DNA, Mitochondrial/me [Metabolism]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Endothelin-1/bl [Blood]
+ Humans
+ Intercellular Adhesion Molecule-1/bl [Blood]
+ Leptin/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/pa [Pathology]
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ Endothelial dysfunction
+ NO
+ Obesity
+ Type 2 diabetes
+ mtDNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Mitochondria play a central role in the regulation of energy metabolism, and the biogenesis of mitochondria is enhanced by the action of nitric oxide (NO), which is the key signaling molecule in the regulation of vascular homeostasis. A disturbance in the regulation of energy metabolism can be a key reason for the formation of insulin resistance and type 2 diabetes mellitus. Moreover, mitochondrial dysfunction leads to oxidative stress, which increases the production of proinflammatory cytokines. In this regard, the aim of this study was to identify the relationship of the copy number of mtDNA in adipose tissue from different locations (subcutaneous adipose tissue (SAT), mesentery (Mes), greater omentum (GO)), liver biopsy samples and mononuclear blood cells (MNCs) with endothelial dysfunction markers (eNOS, ET-1, iCAM-1, vCAM-1, VEGF) and inflammatory mediators (TNF-alpha, IL-6, IL-8, CRP, leptin) in obese patients (body mass index (BMI) > 35 kg/m2) with and without type 2 diabetes.
+
+ METHODS: The study included 88 obese patients (BMI > 35 kg/m2) treated at the Kaliningrad Region Hospital. The control group consisted of 20 healthy donors. To measure mtDNA copy number we used droplet digital PCR. The concentrations of molecules (TNF-alpha, IL-6, IL-8, VEGF, eNOS, ET-1, iCAM-1, vCAM-1, VEGF) were measured in plasma using the following sandwich enzyme-linked immunosorbent assays (ELISAs). Quantitative determination of leptin was evaluated by flow-fluorimetry on a <>. Statistical analysis and graphs were obtained in R Statistical Software (version 3.3.1).
+
+ RESULTS: The systemic character of chronic subclinical inflammation in obesity is established, and an increase in the level of endothelial dysfunction molecules was observed in the blood plasma. The levels of TNF-a, IL-6, and IL-8 were positively correlated with increases in BMI, serum glucose and cholesterol levels.
+
+ CONCLUSIONS: The copy number of mtDNA in various fat stores was higher in obese patients with type 2 diabetes than in obese patients without diabetes or in the control subjects and was related to the levels of leptin and proinflammatory cytokines.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (DNA, Mitochondrial). 0 (Endothelin-1). 0 (Leptin). 0 (Tumor Necrosis Factor-alpha). 126547-89-5 (Intercellular Adhesion Molecule-1). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12920-019-0486-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Litvinova&issn=1755-8794&title=BMC+Medical+Genomics+%5BElectronic+Resource%5D&atitle=The+relationship+between+the+mtDNA+copy+number+in+insulin-dependent+tissues+and+markers+of+endothelial+dysfunction+and+inflammation+in+obese+patients.&volume=12&issue=2&spage=41&epage=&date=2019&doi=10.1186%2Fs12920-019-0486-7&pmid=30871567&sid=OVID:medline
+
+<1743>
+Unique Identifier
+ 30870486
+Title
+ Fecal and blood microbiota profiles and presence of nonalcoholic fatty liver disease in obese versus lean subjects.
+Source
+ PLoS ONE [Electronic Resource]. 14(3):e0213692, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yun Y; Kim HN; Lee EJ; Ryu S; Chang Y; Shin H; Kim HL; Kim TH; Yoo K; Kim HY
+Author NameID
+ Kim, Hwi Young; ORCID: https://orcid.org/0000-0003-0723-1285
+Authors Full Name
+ Yun, Yeojun; Kim, Han-Na; Lee, Eun-Ju; Ryu, Seungho; Chang, Yoosoo; Shin, Hocheol; Kim, Hyung-Lae; Kim, Tae Hun; Yoo, Kwon; Kim, Hwi Young.
+Institution
+ Yun, Yeojun. Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
+ Kim, Han-Na. Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
+ Lee, Eun-Ju. Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
+ Ryu, Seungho. Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
+ Ryu, Seungho. Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
+ Chang, Yoosoo. Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
+ Chang, Yoosoo. Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
+ Shin, Hocheol. Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
+ Kim, Hyung-Lae. Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
+ Kim, Tae Hun. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
+ Yoo, Kwon. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
+ Kim, Hwi Young. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
+MeSH Subject Headings
+ Adult
+ Bacteria/cl [Classification]
+ Biomarkers/me [Metabolism]
+ Blood/mi [Microbiology]
+ Body Mass Index
+ Body Weight
+ Desulfovibrionaceae
+ Feces/mi [Microbiology]
+ Female
+ *Gastrointestinal Microbiome
+ Humans
+ Insulin Resistance
+ Male
+ *Microbiota
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/mi [Microbiology]
+ Normal Distribution
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/mi [Microbiology]
+ Phenotype
+ Phylogeny
+ RNA, Ribosomal, 16S/me [Metabolism]
+Abstract
+ Pathophysiological background in different phenotypes of nonalcoholic fatty liver disease (NAFLD) remains to be elucidated. The aim was to investigate the association between fecal and blood microbiota profiles and the presence of NAFLD in obese versus lean subjects. Demographic and clinical data were reviewed in 268 health checkup examinees, whose fecal and blood samples were available for microbiota analysis. NAFLD was diagnosed with ultrasonography, and subjects with NAFLD were further categorized as obese (body mass index (BMI) >=25) or lean (BMI <25). Fecal and blood microbiota communities were analyzed by sequencing of the V3-V4 domains of the 16S rRNA genes. Correlation between microbiota taxa and NAFLD was assessed using zero-inflated Gaussian mixture models, with adjustment of age, sex, and BMI, and Bonferroni correction. The NAFLD group (n = 76) showed a distinct bacterial community with a lower biodiversity and a far distant phylotype compared with the control group (n = 192). In the gut microbiota, the decrease in Desulfovibrionaceae was associated with NAFLD in the lean NAFLD group (log2 coefficient (coeff.) = -2.107, P = 1.60E-18), but not in the obese NAFLD group (log2 coeff. = 1.440, P = 1.36E-04). In the blood microbiota, Succinivibrionaceae showed opposite correlations in the lean (log2 coeff. = -1.349, P = 5.34E-06) and obese NAFLD groups (log2 coeff. = 2.215, P = 0.003). Notably, Leuconostocaceae was associated with the obese NAFLD in the gut (log2 coeff. = -1.168, P = 0.041) and blood (log2 coeff. = -2.250, P = 1.28E-10). In conclusion, fecal and blood microbiota profiles showed different patterns between subjects with obese and lean NAFLD, which might be potential biomarkers to discriminate diverse phenotypes of NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Ribosomal, 16S).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0213692
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yun&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Fecal+and+blood+microbiota+profiles+and+presence+of+nonalcoholic+fatty+liver+disease+in+obese+versus+lean+subjects.&volume=14&issue=3&spage=e0213692&epage=&date=2019&doi=10.1371%2Fjournal.pone.0213692&pmid=30870486&sid=OVID:medline
+
+<1744>
+Unique Identifier
+ 30864372
+Title
+ No clinical utility of common polymorphisms in IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 genes previously associated with insulin resistance in overweight children from Romania and Moldova.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 32(1):33-39, 2019 Jan 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chirita-Emandi A; Munteanu D; Andreescu N; Tutac P; Paul C; Velea IP; Pusztai AM; Hlistun V; Boiciuc C; Sacara V; Vudu L; Usurelu N; Puiu M
+Authors Full Name
+ Chirita-Emandi, Adela; Munteanu, Diana; Andreescu, Nicoleta; Tutac, Paul; Paul, Corina; Velea, Iulian Puiu; Pusztai, Agneta Maria; Hlistun, Victoria; Boiciuc, Chiril; Sacara, Victoria; Vudu, Lorina; Usurelu, Natalia; Puiu, Maria.
+Institution
+ Chirita-Emandi, Adela. Center of Genomic Medicine, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
+ Chirita-Emandi, Adela. "Louis Turcanu" Emergency Hospital for Children, Timisoara, Romania.
+ Munteanu, Diana. Centre of Reproductive Health and Medical Genetics, Institute of Mother and Child, Chisinau, Republic of Moldova.
+ Munteanu, Diana. Endocrinology Department, University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Republic of Moldova.
+ Andreescu, Nicoleta. Center of Genomic Medicine, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
+ Andreescu, Nicoleta. "Louis Turcanu" Emergency Hospital for Children, Timisoara, Romania.
+ Tutac, Paul. Center of Genomic Medicine, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
+ Paul, Corina. Second Pediatric Clinic, Department of Paediatrics - University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
+ Paul, Corina. Pediatric Department, Clinical County Hospital, Timisoara, Romania.
+ Velea, Iulian Puiu. Second Pediatric Clinic, Department of Paediatrics - University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
+ Velea, Iulian Puiu. Pediatric Department, Clinical County Hospital, Timisoara, Romania.
+ Pusztai, Agneta Maria. Department of Anatomy, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
+ Hlistun, Victoria. Centre of Reproductive Health and Medical Genetics, Institute of Mother and Child, Chisinau, Republic of Moldova.
+ Boiciuc, Chiril. Centre of Reproductive Health and Medical Genetics, Institute of Mother and Child, Chisinau, Republic of Moldova.
+ Sacara, Victoria. Centre of Reproductive Health and Medical Genetics, Institute of Mother and Child, Chisinau, Republic of Moldova.
+ Vudu, Lorina. Endocrinology Department, University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Republic of Moldova.
+ Usurelu, Natalia. Centre of Reproductive Health and Medical Genetics, Institute of Mother and Child, Chisinau, Republic of Moldova.
+ Puiu, Maria. Center of Genomic Medicine, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
+ Puiu, Maria. "Louis Turcanu" Emergency Hospital for Children, Timisoara, Romania.
+MeSH Subject Headings
+ Adaptor Proteins, Signal Transducing/ge [Genetics]
+ Adolescent
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ Child
+ Child, Preschool
+ Co-Repressor Proteins
+ Female
+ Follow-Up Studies
+ Germinal Center Kinases
+ Humans
+ Insulin Receptor Substrate Proteins/ge [Genetics]
+ *Insulin Resistance/ge [Genetics]
+ Insulin-Like Growth Factor I/ge [Genetics]
+ Male
+ Moldova/ep [Epidemiology]
+ Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ PPAR gamma/ge [Genetics]
+ Pediatric Obesity/ep [Epidemiology]
+ *Pediatric Obesity/ge [Genetics]
+ *Polymorphism, Single Nucleotide
+ Prognosis
+ Protein Serine-Threonine Kinases/ge [Genetics]
+ Repressor Proteins/ge [Genetics]
+ Romania/ep [Epidemiology]
+Keyword Heading
+ GCK1
+ GCKR
+ IGF1
+ IRS1
+ KCTD1
+ PPARG
+ children
+ insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Previous genome-wide association studies (GWAS) identified IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 as candidate genes for insulin resistance and type 2 diabetes (T2D). We investigated the associations of these previously reported common variants in these genes with insulin resistance in overweight children from Romania and Moldova. Methods Six single nucleotide polymorphisms (SNPs), IGF1 (rs35767), IRS1 (rs2943634), GCKR (rs780094), PPARG (rs1801282), GCK1 (rs1799884) and KCTD15 (rs29941), were genotyped in 100 overweight children along with clinical and metabolic parameters. Homeostatic model assessment of insulin resistance (HOMA-IR) above 3.4 (defining insulin resistance) was used as the outcome. Results Children differed in insulin resistance status despite having similar body mass index (BMI) standard deviation scores (SDS) (World Health Organization, [WHO] reference). The identified predictors for altered insulin metabolism were higher cholesterol levels, higher diastolic blood pressure and higher waist-to-hip-ratio (as a marker for increased abdominal fat). None of the SNPs showed significant association with increase in the risk for insulin resistance in children (p range=0.478-0.724; odds ratio [OR] range=1.924-4.842); however, the risk allele in GCKR (rs780094, p=0.06, OR=6.871) demonstrated near statistical significance. Conclusions The interrogated risk alleles did not show any significant association with insulin resistance in children in our cohort; however, the GCKR (rs780094) might be a viable candidate in larger cohorts. The lack of replication of the proposed association may point to differences in linkage disequilibrium or effect modifiers across studies.
+Registry Number/Name of Substance
+ 0 (Adaptor Proteins, Signal Transducing). 0 (Biomarkers). 0 (Co-Repressor Proteins). 0 (GCKR protein, human). 0 (Germinal Center Kinases). 0 (IGF1 protein, human). 0 (IRS1 protein, human). 0 (Insulin Receptor Substrate Proteins). 0 (KCTD1 protein, human). 0 (PPAR gamma). 0 (PPARG protein, human). 0 (Repressor Proteins). 67763-96-6 (Insulin-Like Growth Factor I). EC 2-7-11-1 (Protein Serine-Threonine Kinases).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fjpem-2018-0288
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chirita-Emandi&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=No+clinical+utility+of+common+polymorphisms+in+IGF1%2C+IRS1%2C+GCKR%2C+PPARG%2C+GCK1+and+KCTD1+genes+previously+associated+with+insulin+resistance+in+overweight+children+from+Romania+and+Moldova.&volume=32&issue=1&spage=33&epage=39&date=2019&doi=10.1515%2Fjpem-2018-0288&pmid=30864372&sid=OVID:medline
+
+<1745>
+Unique Identifier
+ 30850700
+Title
+ Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome.
+Source
+ Scientific Reports. 9(1):3968, 2019 03 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Maidana P; Fritzler A; Mocarbel Y; Perez Lana MB; Gonzalez D; Rosales M; Gonzalez de Chazal F; Sternberg K; Lamas Majek E; Mallea-Gil S; Genovesi E; Pelayo M; Fabre B; Mesch V
+Author NameID
+ Gonzalez, D; ORCID: https://orcid.org/0000-0001-9670-4827
+Authors Full Name
+ Maidana, P; Fritzler, A; Mocarbel, Y; Perez Lana, M B; Gonzalez, D; Rosales, M; Gonzalez de Chazal, F; Sternberg, K; Lamas Majek, E; Mallea-Gil, S; Genovesi, E; Pelayo, M; Fabre, B; Mesch, V.
+Institution
+ Maidana, P. Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica - Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Buenos Aires, Argentina.
+ Fritzler, A. Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica - Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Buenos Aires, Argentina.
+ Mocarbel, Y. Universidad de Buenos Aires, Hospital de Clinicas "Jose de San Martin", Division Endocrinologia, Buenos Aires, Argentina.
+ Perez Lana, M B. Universidad de Buenos Aires, Hospital de Clinicas "Jose de San Martin", Division Ginecologia, Buenos Aires, Argentina.
+ Gonzalez, D. Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica - Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Buenos Aires, Argentina.
+ Rosales, M. Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica - Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Buenos Aires, Argentina.
+ Gonzalez de Chazal, F. Universidad de Buenos Aires, Hospital de Clinicas "Jose de San Martin", Division Ginecologia, Buenos Aires, Argentina.
+ Sternberg, K. Universidad de Buenos Aires, Hospital de Clinicas "Jose de San Martin", Division Ginecologia, Buenos Aires, Argentina.
+ Lamas Majek, E. Universidad de Buenos Aires, Hospital de Clinicas "Jose de San Martin", Division Ginecologia, Buenos Aires, Argentina.
+ Mallea-Gil, S. Servicio de Endocrinologia, Hospital Militar Central, Buenos Aires, Argentina.
+ Genovesi, E. Universidad de Buenos Aires, Hospital de Clinicas "Jose de San Martin", Division Endocrinologia, Buenos Aires, Argentina.
+ Pelayo, M. Universidad de Buenos Aires, Hospital de Clinicas "Jose de San Martin", Division Endocrinologia, Buenos Aires, Argentina.
+ Fabre, B. Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica - Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Buenos Aires, Argentina.
+ Mesch, V. Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica - Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Buenos Aires, Argentina. vmesch@ffyb.uba.ar.
+MeSH Subject Headings
+ Adolescent
+ Adrenal Cortex Hormones/me [Metabolism]
+ *Adrenal Glands/me [Metabolism]
+ Adult
+ *Biomarkers/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ Female
+ Humans
+ *Inflammation/me [Metabolism]
+ Male
+ Obesity/me [Metabolism]
+ *Polycystic Ovary Syndrome/me [Metabolism]
+ *Vitamin D/me [Metabolism]
+ Vitamin D Deficiency/me [Metabolism]
+ Waist Circumference/ph [Physiology]
+ Young Adult
+Abstract
+ Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabolic alterations and inflammation markers in PCOS. In 73 patients and 33 controls, 25-hydroxyvitamin D (25-OH-D), total and bioavailable testosterone (TT and bioT), androstenedione (A4), SHBG, cortisol, insulin, and C-reactive protein (hs-CRP) were determined; HOMA and lipid accumulation product (LAP) index were calculated. All parameters were higher in patients than in controls, except for SHBG and 25-OH-D which were lower. Binary regression analysis showed that differences in TT, bioT, A4, insulin and HOMA were independent of body mass index and waist circumference but SHBG, hs-CRP, LAP and 25-OH-D were related to body weight and fat distribution. Binary logistic regression analysis showed that cortisol and 25-OH-D could be associated to PCOS development. Correlations found between LAP and insulin, HOMA and hs-CRP confirm it is a good indicator of metabolic complications. Vitamin D and cortisol association to PCOS development justifies future research to understand the role of vitamin D in PCOS and analyze patient's perinatal history and its possible relationship with hyperactivation of adrenal axis in adult life.
+Registry Number/Name of Substance
+ 0 (Adrenal Cortex Hormones). 0 (Biomarkers). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-40653-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Maidana&issn=2045-2322&title=Scientific+Reports&atitle=Association+Between+Vitamin+D+and+Adrenal+Parameters+with+Metabolic+and+Inflammatory+Markers+in+Polycystic+Ovary+Syndrome.&volume=9&issue=1&spage=3968&epage=&date=2019&doi=10.1038%2Fs41598-019-40653-z&pmid=30850700&sid=OVID:medline
+
+<1746>
+Unique Identifier
+ 30847861
+Title
+ The resting metabolic rate in women with polycystic ovary syndrome and its relation to the hormonal milieu, insulin metabolism, and body fat distribution: a cohort study.
+Source
+ Journal of Endocrinological Investigation. 42(9):1089-1097, 2019 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Romualdi D; Versace V; Tagliaferri V; De Cicco S; Immediata V; Apa R; Guido M; Lanzone A
+Authors Full Name
+ Romualdi, D; Versace, V; Tagliaferri, V; De Cicco, S; Immediata, V; Apa, R; Guido, M; Lanzone, A.
+Institution
+ Romualdi, D. Department Of Woman And Child Health And Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore, 00168, Rome, Italy. daniela.romualdi@policlinicogemelli.it.
+ Romualdi, D. Department Of Woman And Child Health, Division of Obstetrics and Gynecology, Azienda Ospedaliera "Cardinale Panico", 73039, Tricase, Italy. daniela.romualdi@policlinicogemelli.it.
+ Versace, V. Department Of Woman And Child Health And Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore, 00168, Rome, Italy.
+ Tagliaferri, V. Department of Obstetrics and Gynaecology, Ente Ecclesiastico Ospedale Generale Regionale "F. Miulli", 70021, Acquaviva delle Fonti, Italy.
+ De Cicco, S. Department Of Woman And Child Health And Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore, 00168, Rome, Italy.
+ Immediata, V. Department Of Woman And Child Health And Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore, 00168, Rome, Italy.
+ Apa, R. Department Of Woman And Child Health And Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore, 00168, Rome, Italy.
+ Guido, M. Department of Obstetrics and Gynaecology, Ente Ecclesiastico Ospedale Generale Regionale "F. Miulli", 70021, Acquaviva delle Fonti, Italy.
+ Lanzone, A. Department Of Woman And Child Health And Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore, 00168, Rome, Italy.
+MeSH Subject Headings
+ Adult
+ *Basal Metabolism
+ *Biomarkers/an [Analysis]
+ *Body Fat Distribution
+ Body Mass Index
+ Case-Control Studies
+ *Estradiol/bl [Blood]
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin/me [Metabolism]
+ Insulin Resistance
+ Lipids/bl [Blood]
+ *Obesity/bl [Blood]
+ Polycystic Ovary Syndrome/bl [Blood]
+ *Polycystic Ovary Syndrome/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Sex Hormone-Binding Globulin/an [Analysis]
+Keyword Heading
+ Energy expenditure
+ Polycystic ovary syndrome
+ Resting metabolic rate
+ SenseWear armband
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: To evaluate possible alterations of a major determinant of energy expenditure, the resting metabolic rate (RMR), in women with polycystic ovary syndrome (PCOS) compared with age-BMI similar controls. To assess whether the hormonal milieu, the body fat distribution and the insulin metabolism may affect energy consumption in these patients.
+
+ METHODS: This is a monocentric observational prospective cohort study, including 109 Caucasian PCOS subjects and 31 healthy control women. (Median age PCOS 26.0 +/- 9.2 years, controls 25.5 +/- 8.5 years; median BMI-body mass index PCOS 26.4 +/- 9.4 kg/m2, controls 27.2 +/- 12.8 kg/m2). RMR was evaluated by the SenseWear Armband (SWA), a reliable and validated metabolic holter, never previously used in the PCOS population to this purpose. Hormonal assessment, insulin metabolism evaluated by HOMA-IR and OGTT, anthropometric features (BMI and WHR) were also assessed.
+
+ RESULTS: Median RMR resulted similar in PCOS and control women: 1520.0 +/- 248.00 kcal/day vs 1464.0 +/- 332.70 kcal/day (p = 0.472), even after adjusting for BMI, fat distribution, insulin metabolism parameters. RMR resulted significantly correlated with BMI, WHR, estradiol levels, SHBG, total cholesterol, triglycerides, basal glycaemia, basal insulinemia, AUC insulin 240', and HOMA. In the subgroup of patients with WHR > 0.85, PCOS women showed a significantly lower RMR compared with controls.
+
+ CONCLUSIONS: The higher prevalence of obesity, which negatively influences the reproductive and general health of PCOS women, could be related to factors other than an intrinsic alteration of the RMR. Further studies are needed to clarify the possible role of the visceral fat in modulating the energy balance in PCOS.
+
+ TRIAL REGISTRATION NUMBER: clinicaltrials.gov Identifier NCT03132545.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). 0 (Lipids). 0 (SHBG protein, human). 0 (Sex Hormone-Binding Globulin). 4TI98Z838E (Estradiol).
+Publication Type
+ Clinical Trial. Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs40618-019-01029-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Romualdi&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=The+resting+metabolic+rate+in+women+with+polycystic+ovary+syndrome+and+its+relation+to+the+hormonal+milieu%2C+insulin+metabolism%2C+and+body+fat+distribution%3A+a+cohort+study.&volume=42&issue=9&spage=1089&epage=1097&date=2019&doi=10.1007%2Fs40618-019-01029-2&pmid=30847861&sid=OVID:medline
+
+<1747>
+Unique Identifier
+ 30845211
+Title
+ Normative range of blood biochemical parameters in urban Indian school-going adolescents.
+Source
+ PLoS ONE [Electronic Resource]. 14(3):e0213255, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bandesh K; Jha P; Giri AK; Marwaha RK; Scaria V; Tandon N; Bharadwaj D
+Author NameID
+ Jha, Punam; ORCID: https://orcid.org/0000-0003-3270-5526
+ Bharadwaj, Dwaipayan; ORCID: https://orcid.org/0000-0001-5268-8482
+Corporate Author
+ INDICO
+Authors Full Name
+ Bandesh, Khushdeep; Jha, Punam; Giri, Anil K; Marwaha, Raman K; Scaria, Vinod; Tandon, Nikhil; Bharadwaj, Dwaipayan.
+Institution
+ Bandesh, Khushdeep. Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
+ Bandesh, Khushdeep. Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.
+ Jha, Punam. Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
+ Jha, Punam. Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.
+ Giri, Anil K. Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
+ Giri, Anil K. Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.
+ Marwaha, Raman K. Senior consultant endocrinologist and Scientific Advisor (Projects), International Life Sciences Institute-India, New Delhi, India.
+ Scaria, Vinod. Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.
+ Scaria, Vinod. GN Ramachandran Knowledge Center for Genome Informatics, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.
+ Tandon, Nikhil. Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
+ Bharadwaj, Dwaipayan. Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
+ Bharadwaj, Dwaipayan. Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.
+ Bharadwaj, Dwaipayan. Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ *Blood Glucose/an [Analysis]
+ *Body Mass Index
+ *C-Peptide/bl [Blood]
+ Child
+ Cross-Sectional Studies
+ Fasting
+ Female
+ Humans
+ *Insulin/bl [Blood]
+ *Lipids/bl [Blood]
+ Male
+ *Obesity/pp [Physiopathology]
+ Sex Factors
+ Sexual Maturation
+Abstract
+ Adolescence is the most critical phase of human growth that radically alters physiology of the body and wherein any inconsistency can lead to serious health consequences in adulthood. The timing and pace at which various developmental events occur during adolescence is highly diverse and thus results in a drastic change in blood biochemistry. Monitoring the physiological levels of various biochemical measures in ample number of individuals during adolescence can call up for an early intervention in managing metabolic diseases in adulthood. Today, only a couple of studies in different populations have investigated blood biochemistry in a small number of adolescents however, there is no comprehensive biochemical data available worldwide. In view, we performed a cross-sectional study in a sizeable group of 7,618 Indian adolescents (3,333 boys and 4,285 girls) aged between 11-17 years to inspect the distribution of values of common biochemical parameters that generally prevails during adolescence and we observed that various parameters considerably follow the reported values from different populations being 3.56-6.49mmol/L (fasting glucose), 10.60-199.48pmol/L (insulin), 0.21-3.22nmol/L (C-peptide), 3.85-6.25% (HbA1c), 2.49-5.54mmol/L (total cholesterol), 1.16-3.69mmol/L (LDL), 0.78-1.85mmol/L (HDL), 0.33-2.24mmol/L (triglycerides), 3.56-11.45mmol/L (urea), 130.01-440.15mumol/L (uric acid) and 22.99-74.28mumol/L (creatinine). Barring LDL and triglycerides, all parameters differed significantly between boys and girls (p< 0.001). Highest difference was seen for uric acid (p = 1.3 x10-187) followed by C-peptide (p = 6.6 x10-89). Across all ages during adolescence, glycemic and nitrogen metabolites parameters varied markedly with gender. Amongst lipid parameters, only HDL levels were found to be significantly associated with gender following puberty (p< 0.001). All parameters except urea, differed considerably in obese and lean adolescents (p< 0.0001). The present study asserts that age, sex and BMI are the essential contributors to variability in blood biochemistry during adolescence. Our composite data on common blood biochemical measures will benefit future endeavors to define reference intervals in adolescents especially when the global availability is scarce.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (C-Peptide). 0 (Insulin). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0213255
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bandesh&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Normative+range+of+blood+biochemical+parameters+in+urban+Indian+school-going+adolescents.&volume=14&issue=3&spage=e0213255&epage=&date=2019&doi=10.1371%2Fjournal.pone.0213255&pmid=30845211&sid=OVID:medline
+
+<1748>
+Unique Identifier
+ 30845159
+Title
+ The association of serum 25-hydroxyvitamin D concentrations with elevated serum ferritin levels in normal weight, overweight and obese Canadians.
+Source
+ PLoS ONE [Electronic Resource]. 14(3):e0213260, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Munasinghe LL; Ekwaru JP; Mastroeni MF; Mastroeni SSBS; Veugelers PJ
+Author NameID
+ Munasinghe, Lalani L; ORCID: https://orcid.org/0000-0001-5859-9579
+ Veugelers, Paul J; ORCID: https://orcid.org/0000-0001-8996-0822
+Authors Full Name
+ Munasinghe, Lalani L; Ekwaru, John P; Mastroeni, Marco F; Mastroeni, Silmara S B S; Veugelers, Paul J.
+Institution
+ Munasinghe, Lalani L. School of Public Health, University of Alberta, Edmonton, Alberta, Canada.
+ Ekwaru, John P. School of Public Health, University of Alberta, Edmonton, Alberta, Canada.
+ Mastroeni, Marco F. Post-graduation Program in Health and Environment, University of Joinville Region, Joinville, Brazil.
+ Mastroeni, Silmara S B S. Department of Physical Education, University of Joinville Region, Joinville, Brazil.
+ Veugelers, Paul J. School of Public Health, University of Alberta, Edmonton, Alberta, Canada.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ *Biomarkers/bl [Blood]
+ Canada/ep [Epidemiology]
+ Case-Control Studies
+ Child
+ Child, Preschool
+ Female
+ *Ferritins/bl [Blood]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Overweight/bl [Blood]
+ Overweight/ep [Epidemiology]
+ *Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ *Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/co [Complications]
+ *Vitamins/bl [Blood]
+ Young Adult
+Abstract
+ In light of the growing body of literature suggesting a beneficial effect of vitamin D on inflammatory response, we hypothesized that vitamin D affects serum ferritin (SF), a biomarker of inflammation. The objective of the present study is to examine the association of serum 25-hydroxyvitamin D [25(OH)D] with elevated SF concentrations indicative of inflammation as no earlier study has done so. Data from 5550 Canadian adults who participated in the 2012/2013 and the 2014/2015 Canadian Health Measures Surveys were analysed. We observed that 9.4% of Canadian adults have elevated SF concentrations and that 35.6% were vitamin D insufficient. Among Canadians with under/normal body weights, those with serum 25(OH)D >= 75 nmol/L relative to those with serum 25(OH)D < 50 nmol/L, were substantially less at risk for elevated SF concentrations (OR = 0.24; 95% CI = 0.06, 0.89; p = 0.034). We did not observe this association for overweight and obese Canadians. Canadians of older age, non-white ethnicity, males, those with income above $100,000, those who consumed alcohol, and those with high total cholesterol concentrations and elevated blood pressures were more likely to have elevated SF concentrations. Serum 25(OH)D >= 75 nmol/L is likely to provoke anti-inflammatory benefits, but intervention studies that achieve high 25(OH)D concentrations and with long follow up are needed to establish the role of vitamin D on SF.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Vitamins). 1406-16-2 (Vitamin D). 9007-73-2 (Ferritins). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0213260
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Munasinghe&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=The+association+of+serum+25-hydroxyvitamin+D+concentrations+with+elevated+serum+ferritin+levels+in+normal+weight%2C+overweight+and+obese+Canadians.&volume=14&issue=3&spage=e0213260&epage=&date=2019&doi=10.1371%2Fjournal.pone.0213260&pmid=30845159&sid=OVID:medline
+
+<1749>
+Unique Identifier
+ 30844741
+Title
+ Targeting risk factors for reducing the racially disparate burden in breast cancer. [Review]
+Source
+ Frontiers in Bioscience. 11(1):136-160, 2019 03 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wright N; Akinyemiju T; Subhedar P; Rida P; Aneja R
+Authors Full Name
+ Wright, Nikita; Akinyemiju, Tomi; Subhedar, Preeti; Rida, Padmashree; Aneja, Ritu.
+Institution
+ Wright, Nikita. Georgia State University, Atlanta, GA 30303.
+ Akinyemiju, Tomi. University of Kentucky, Lexington, KY 40504.
+ Subhedar, Preeti. Emory University School of Medicine, Atlanta, GA 30322.
+ Rida, Padmashree. Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
+ Aneja, Ritu. Department of Biology, International Consortium for Advancing Research on Triple Negative Breast Cancer, Georgia State University, Atlanta, GA 30303, USA, raneja@gsu.edu.
+MeSH Subject Headings
+ Black or African American/ge [Genetics]
+ Alcohol Drinking
+ Biomarkers
+ Body Size
+ Breast/pa [Pathology]
+ Breast Neoplasms/dt [Drug Therapy]
+ *Breast Neoplasms/eh [Ethnology]
+ *Breast Neoplasms/ge [Genetics]
+ Cultural Characteristics
+ Diabetes Mellitus/eh [Ethnology]
+ Diabetes Mellitus/ge [Genetics]
+ Educational Status
+ Endocrine Disruptors
+ Fear
+ Female
+ Health Status Disparities
+ Hormone Replacement Therapy
+ Humans
+ Hypertension/co [Complications]
+ Hypertension/eh [Ethnology]
+ Hypertension/ge [Genetics]
+ Insurance, Health
+ Life Style
+ Menarche
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/eh [Ethnology]
+ Obesity/ge [Genetics]
+ Religion
+ Residence Characteristics
+ Risk Factors
+ Sleep
+ Stress, Psychological
+ Transportation
+ White People/ge [Genetics]
+Abstract
+ African-American (AA) women are more likely to die from breast cancer (BC), at any age, compared to European-American women. Although breakthroughs in pre-clinical studies have resulted in potentially actionable targets in AA BC, drugs that were rationally designed for these targets have performed poorly in clinical trials. Challenges with interpatient and intratumoral heterogeneity, lack of drug sensitivity and specificity, suboptimal biomarker cut-offs, lack of drug response predictive biomarkers, drug side effects, high costs of drug development, and under-representation of AAs in clinical trials complicate the development of targeted therapies for AA BC patients. Accumulating evidence suggests that racial disparities exist in non-genetic risk factors that can alter genetic and epigenetic programs to promote breast tumorigenesis. Herein, we present a "roadmap" that addresses non-genetic risk factors that are suspected to contribute to the racial disparity in BC mortality. Increased targeting of these non-genetic risk factors may proffer a safer and more economical route to alleviating the racially disparate burden in BC.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Endocrine Disruptors).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2741%2fS531
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wright&issn=1945-0516&title=Frontiers+in+Bioscience&atitle=Targeting+risk+factors+for+reducing+the+racially+disparate+burden+in+breast+cancer.&volume=11&issue=1&spage=136&epage=160&date=2019&doi=10.2741%2FS531&pmid=30844741&sid=OVID:medline
+
+<1750>
+Unique Identifier
+ 30839239
+Title
+ Body Weight Reduction of 5% Improved Blood Pressure and Lipid Profiles in Obese Men and Blood Glucose in Obese Women: A Four-Year Follow-up Observational Study.
+Source
+ Metabolic Syndrome & Related Disorders. 17(5):250-258, 2019 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hasegawa Y; Nakagami T; Oya J; Takahashi K; Isago C; Kurita M; Tanaka Y; Ito A; Kasahara T; Uchigata Y
+Authors Full Name
+ Hasegawa, Yukiko; Nakagami, Tomoko; Oya, Junko; Takahashi, Kanako; Isago, Chisato; Kurita, Moritoshi; Tanaka, Yuki; Ito, Arata; Kasahara, Tadasu; Uchigata, Yasuko.
+Institution
+ Hasegawa, Yukiko. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Nakagami, Tomoko. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Oya, Junko. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Takahashi, Kanako. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Takahashi, Kanako. 2 Department of Internal Medicine, Yoyogi Hospital, Tokyo, Japan.
+ Isago, Chisato. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Kurita, Moritoshi. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Kurita, Moritoshi. 3 Department of Internal Medicine, Saitama-ken Saiseikai Kurihashi Hospital, Saitama, Japan.
+ Tanaka, Yuki. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Tanaka, Yuki. 4 Department of Internal Medicine, Josai Hospital, Tokyo, Japan.
+ Ito, Arata. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Kasahara, Tadasu. 4 Department of Internal Medicine, Josai Hospital, Tokyo, Japan.
+ Uchigata, Yasuko. 1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
+ Uchigata, Yasuko. 5 Department of Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Alcohol Abstinence
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Blood Pressure
+ Diet, Healthy
+ Exercise
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/me [Metabolism]
+ *Healthy Lifestyle
+ Humans
+ Japan
+ *Lipids/bl [Blood]
+ Male
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ *Risk Reduction Behavior
+ Smoking Cessation
+ Time Factors
+ Treatment Outcome
+ *Weight Loss
+Keyword Heading
+ body weight change
+ metabolic syndrome
+ obesity
+ physical activity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Body weight reduction (BWR) of at least 3% in obese Japanese individuals through lifestyle interventions has improved the risk factors for cardiovascular disease (CVD). We aimed to assess the relation between body weight change (BWC) and CVD risk change and to identify lifestyle improvement related to BWR in obese Japanese individuals. Methods: Subjects were 2579 health checkup examinees without medicated diabetes, hypertension or dyslipidemia, and a body mass index >=25 kg/m2 who completed lifestyle questionnaires in 2008 and 2012. The 4-year changes in fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), lipids, and blood pressure (BP) levels were compared across the five groups based on the 4-year BWC, and presented as <-5%, -5% to -3%, -3% to -1%, -1% to 1%, and >=1%. Multivariable logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CI) for lifestyle improvement related to BWR. Results: Comparing the groups to the reference group (BWC ranging from -1% to +1%), we observed that FPG and HbA1c levels were lower in women in the <-5% group; BP levels were also lower in the <-5% group; triglyceride levels had improved in the <-3% group, and low-density lipoprotein cholesterol levels in the <-5% group; high-density lipoprotein cholesterol levels had improved in men in the <-5% group. In men, the adjusted OR (95% CI) for BWR related to lifestyle improvement pertaining to "over 30 min exercise" was 2.6 (2.0-3.6). In women, the adjusted ORs for BWR related to "walking or physical activity," "drinking alcohol," and "drinking more than a glass of sake" were 1.7 (1.1-2.7), 1.9 (1.1-3.5), and 1.8 (1.1-3.0), respectively. Conclusions: A 5% BWR improved FPG and HbA1c levels in obese women, and BP and lipid levels in obese men. Improvements in exercise and alcohol consumption habits were associated with BWR in this population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Lipids). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Comparative Study. Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1089%2fmet.2018.0115
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hasegawa&issn=1540-4196&title=Metabolic+Syndrome+%26+Related+Disorders&atitle=Body+Weight+Reduction+of+5%25+Improved+Blood+Pressure+and+Lipid+Profiles+in+Obese+Men+and+Blood+Glucose+in+Obese+Women%3A+A+Four-Year+Follow-up+Observational+Study.&volume=17&issue=5&spage=250&epage=258&date=2019&doi=10.1089%2Fmet.2018.0115&pmid=30839239&sid=OVID:medline
+
+<1751>
+Unique Identifier
+ 30837522
+Title
+ Discovery and Validation of a Novel Neutrophil Activation Marker Associated with Obesity.
+Source
+ Scientific Reports. 9(1):3433, 2019 03 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pan Y; Choi JH; Shi H; Zhang L; Su S; Wang X
+Authors Full Name
+ Pan, Yue; Choi, Jeong-Hyeon; Shi, Huidong; Zhang, Liwen; Su, Shaoyong; Wang, Xiaoling.
+Institution
+ Pan, Yue. Georgia Prevention Institute, Augusta University, Augusta, Gerogia, USA.
+ Choi, Jeong-Hyeon. Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.
+ Shi, Huidong. Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.
+ Zhang, Liwen. Proteomic Shared Resources, Mass Spectrometry and Proteomics Facility, Ohio State University, Columbus, USA.
+ Su, Shaoyong. Georgia Prevention Institute, Augusta University, Augusta, Gerogia, USA.
+ Wang, Xiaoling. Georgia Prevention Institute, Augusta University, Augusta, Gerogia, USA. xwang@augusta.edu.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers
+ Body Mass Index
+ Carotid Intima-Media Thickness
+ *Disease Susceptibility
+ Female
+ Gene Expression Profiling
+ Gene Expression Regulation
+ Humans
+ Leukocytes/im [Immunology]
+ Leukocytes/me [Metabolism]
+ Male
+ *Neutrophil Activation/im [Immunology]
+ *Neutrophils/im [Immunology]
+ *Neutrophils/me [Metabolism]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Phenotype
+ Proteome
+ Proteomics/mt [Methods]
+ Young Adult
+Abstract
+ Obesity is accompanied by low-grade systemic inflammation that etiologically contributes to obesity-induced cardiovascular disease (CVD). Growing evidence supports that neutrophil, the most abundant type of leukocytes in human, is most likely to be the target peripheral leukocyte subtype initiating the inflammatory cascade in obesity. However, few studies have systematically assessed the genome wide changes in neutrophils associated with obesity. In this study, a hypothesis-free OMIC approach (i.e. the discovery phase) and a target approach (i.e. the validation phase) were used to identify obesity related neutrophil activation markers and their roles on CVD risks. In the discovery phase, genome wide DNA methylation, RNA-sequencing and quantitative proteomics were obtained from purified neutrophils (12 obese vs. 12 lean). In the validation phase, gene expression levels of the promising genes from the OMIC platforms were measured in 81 obese cases vs. 83 lean controls, and the association between the expression levels and CVD risks were evaluated. Significant difference was found for one gene, alkaline phosphatase, liver/bone/kidney (ALPL), across 3 OMIC platforms. In the validation phase, the gene expression levels of ALPL in leukocytes were significantly higher in obese compared with lean subjects (p < 0.05). Within the obese population, we observed that ALPL expression level showed significantly positive association with CVD risk factors (p < 0.05) including systolic blood pressure, diastolic blood pressure, mean arterial pressure, carotid intima-media thickness and borderline significance with fasting insulin (p = 0.08). This study identified one novel marker ALPL of neutrophil activation in response to obesity and provided evidence that obesity induced change in ALPL expression was associated with CVD risk factors.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteome).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-39764-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pan&issn=2045-2322&title=Scientific+Reports&atitle=Discovery+and+Validation+of+a+Novel+Neutrophil+Activation+Marker+Associated+with+Obesity.&volume=9&issue=1&spage=3433&epage=&date=2019&doi=10.1038%2Fs41598-019-39764-4&pmid=30837522&sid=OVID:medline
+
+<1752>
+Unique Identifier
+ 30836637
+Title
+ Similar Weight Loss Induces Greater Improvements in Insulin Sensitivity and Liver Function among Individuals with NAFLD Compared to Individuals without NAFLD.
+Source
+ Nutrients. 11(3), 2019 Mar 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schubel R; Nonnenmacher T; Sookthai D; Gonzalez Maldonado S; Sowah SA; von Stackelberg O; Schlett CL; Grafetstatter M; Nabers D; Johnson T; Kirsten R; Ulrich CM; Kaaks R; Kauczor HU; Kuhn T; Nattenmuller J
+Author NameID
+ Johnson, Theron; ORCID: https://orcid.org/0000-0003-4850-282X
+ Ulrich, Cornelia M; ORCID: https://orcid.org/0000-0001-7641-059X
+Authors Full Name
+ Schubel, Ruth; Nonnenmacher, Tobias; Sookthai, Disorn; Gonzalez Maldonado, Sandra; Sowah, Solomon A; von Stackelberg, Oyunbileg; Schlett, Christopher L; Grafetstatter, Mirja; Nabers, Diana; Johnson, Theron; Kirsten, Romy; Ulrich, Cornelia M; Kaaks, Rudolf; Kauczor, Hans-Ulrich; Kuhn, Tilman; Nattenmuller, Johanna.
+Institution
+ Schubel, Ruth. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Ruth.Schuebel@med.uni-heidelberg.de.
+ Schubel, Ruth. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. Ruth.Schuebel@med.uni-heidelberg.de.
+ Nonnenmacher, Tobias. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. tno144@googlemail.com.
+ Sookthai, Disorn. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. d.sookthai@dkfz-heidelberg.de.
+ Gonzalez Maldonado, Sandra. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. s.gonzalezmaldonado@dkfz-heidelberg.de.
+ Sowah, Solomon A. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. s.sowah@dkfz-heidelberg.de.
+ von Stackelberg, Oyunbileg. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. oyunbileg.stackelberg@med.uni-heidelberg.de.
+ Schlett, Christopher L. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. Christopher.Schlett@med.uni-heidelberg.de.
+ Grafetstatter, Mirja. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. mi.graf@dkfz-heidelberg.de.
+ Nabers, Diana. German Cancer Research Center (DKFZ), Division of Medical and Biological Informatics, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. d.nabers@dkfz-heidelberg.de.
+ Johnson, Theron. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. t.johnson@Dkfz-Heidelberg.de.
+ Kirsten, Romy. National Center for Tumor Diseases (NCT), Liquid Biobank, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. romy.kirsten@nct-heidelberg.de.
+ Ulrich, Cornelia M. Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112-5550, USA. neli@hci.utah.edu.
+ Kaaks, Rudolf. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. r.kaaks@Dkfz-Heidelberg.de.
+ Kauczor, Hans-Ulrich. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. Hans-Ulrich.Kauczor@med.uni-heidelberg.de.
+ Kuhn, Tilman. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. t.kuehn@dkfz-heidelberg.de.
+ Nattenmuller, Johanna. Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. Johanna.nattenmueller@med.uni-heidelberg.de.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Diet, Reducing
+ Female
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ *Liver/pp [Physiopathology]
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/dh [Diet Therapy]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/pp [Physiopathology]
+ Obesity/co [Complications]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Treatment Outcome
+ *Weight Loss/ph [Physiology]
+Keyword Heading
+ insulin sensitivity
+ liver function
+ magnetic resonance imaging
+ non-alcoholic fatty liver disease
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Preliminary evidence suggests that weight loss among obese has differential metabolic effects depending on the presence of non-alcoholic fatty liver disease (NAFLD). We assessed whether NAFLD predisposes to differential changes in liver fat content, liver function, and metabolic parameters upon diet-induced weight loss in a 50-week intervention trial.
+
+ METHODS: 143 overweight and obese non-smokers underwent a 12-week dietary intervention and a 38-week follow-up. Diet-induced changes in anthropometric measures, circulating biomarkers, and magnetic resonance (MR)-derived liver fat content and adipose tissue volumes were evaluated by mixed linear models stratifying by NAFLD at baseline.
+
+ RESULTS: The prevalence of NAFLD at baseline was 52%. Diet-induced weight loss after 12 (NAFLD: 4.8 +/- 0.5%, No NAFLD: 5.1 +/- 0.5%) and 50 weeks (NAFLD: 3.5 +/- 0.7%, No NAFLD: 3.5 +/- 0.9%) was similar in both groups, while the decrease in liver fat was significantly greater in the NAFLD group (week 12: 32.9 +/- 9.5% vs. 6.3 +/- 4.0%; week 50: 23.3 +/- 4.4% vs. 5.0 +/- 4.2%). Decreases in biomarkers of liver dysfunction (GGT, ALT, AST) and HOMA IR were also significantly greater in the NAFLD group. Other metabolic parameters showed no significant differences.
+
+ CONCLUSION: Our data suggest that individuals with NAFLD show greater improvements of liver function and insulin sensitivity after moderate diet-induced weight loss than individuals without NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11030544
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schubel&issn=2072-6643&title=Nutrients&atitle=Similar+Weight+Loss+Induces+Greater+Improvements+in+Insulin+Sensitivity+and+Liver+Function+among+Individuals+with+NAFLD+Compared+to+Individuals+without+NAFLD.&volume=11&issue=3&spage=&epage=&date=2019&doi=10.3390%2Fnu11030544&pmid=30836637&sid=OVID:medline
+
+<1753>
+Unique Identifier
+ 30833801
+Title
+ Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease via the modulation of the gut microbiota in rabbits.
+Source
+ World Journal of Gastroenterology. 25(8):955-966, 2019 Feb 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xing YW; Lei GT; Wu QH; Jiang Y; Huang MX
+Authors Full Name
+ Xing, Ya-Wei; Lei, Guang-Tao; Wu, Qing-Hua; Jiang, Yu; Huang, Man-Xiang.
+Institution
+ Xing, Ya-Wei. Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
+ Lei, Guang-Tao. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. lgtmhu@163.com.
+ Wu, Qing-Hua. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
+ Jiang, Yu. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
+ Huang, Man-Xiang. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
+MeSH Subject Headings
+ Animals
+ Bacteroidetes/de [Drug Effects]
+ Bacteroidetes/ge [Genetics]
+ Bacteroidetes/ip [Isolation & Purification]
+ *Biflavonoids/pd [Pharmacology]
+ Biflavonoids/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ Body Weight/de [Drug Effects]
+ *Catechin/pd [Pharmacology]
+ Catechin/tu [Therapeutic Use]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ *Gastrointestinal Microbiome/de [Drug Effects]
+ Gastrointestinal Microbiome/ge [Genetics]
+ Humans
+ Insulin Resistance
+ Lipopolysaccharides/bl [Blood]
+ Liver/de [Drug Effects]
+ Liver/pa [Pathology]
+ Male
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Non-alcoholic Fatty Liver Disease/pc [Prevention & Control]
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ *Obesity/pc [Prevention & Control]
+ *Proanthocyanidins/pd [Pharmacology]
+ Proanthocyanidins/tu [Therapeutic Use]
+ *Protective Agents/pd [Pharmacology]
+ Protective Agents/tu [Therapeutic Use]
+ RNA, Ribosomal, 16S/ip [Isolation & Purification]
+ Rabbits
+ Treatment Outcome
+ Triglycerides/bl [Blood]
+Keyword Heading
+ 16S rRNA
+ Gut microbiota
+ Non-alcoholic fatty liver disease
+ Procyanidin
+ Rabbit
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Procyanidins have beneficial effects on metabolic syndrome and antimicrobial activity, but the mechanisms underlying these effects are unclear.
+
+ AIM: To investigate the effects of procyanidin B2 (PB2) on non-alcoholic fatty liver disease and to explore the possible mechanism.
+
+ METHODS: Thirty male New Zealand white rabbits were randomized into three groups. All of them were fed either a high-fat-cholesterol diet (HCD) or chow diet. HCD-fed rabbits were treated with vehicle or PB2 daily for 12 wk. Body weight and food intake were evaluated once a week. Serum biomarkers, such as total cholesterols, triglycerides, and aspartate transaminase, were detected. All rabbits were sacrificed and histological parameters of liver were assessed by hematoxylin and eosin-stained sections. Moreover, several lipogenic genes and gut microbiota (by 16S rRNA sequencing) were investigated to explore the possible mechanism.
+
+ RESULTS: The HCD group had higher body weight, liver index, serum lipid profile, insulin resistance, serum glucose, and hepatic steatosis compared to the CHOW group. PB2 treatment prevented HCD-induced increases in body weight and hypertriglyceridemia in association with triglyceride accumulation in the liver. PB2 also ameliorated low-grade inflammation, which was reflected by serum lipopolysaccharides and improved insulin resistance. In rabbit liver, PB2 prevented the upregulation of steroid response element binding protein 1c and fatty acid synthase and the downregulation of carnitine palmitoyltransferase, compared to the HCD group. Moreover, HCD led to a decrease of Bacteroidetes in gut microbiota. PB2 significantly improved the proportions of Bacteroidetes at the phylum level and Akkermansia at the genus level.
+
+ CONCLUSION: Our results indicate the possible mechanism of PB2 to improve HCD-induced features of metabolic syndrome and provide a new dietary supplement.
+Registry Number/Name of Substance
+ 0 (Biflavonoids). 0 (Biomarkers). 0 (Lipopolysaccharides). 0 (Proanthocyanidins). 0 (Protective Agents). 0 (RNA, Ribosomal, 16S). 0 (Triglycerides). 29106-49-8 (procyanidin B2). 8R1V1STN48 (Catechin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3748%2fwjg.v25.i8.955
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xing&issn=1007-9327&title=World+Journal+of+Gastroenterology&atitle=Procyanidin+B2+protects+against+diet-induced+obesity+and+non-alcoholic+fatty+liver+disease+via+the+modulation+of+the+gut+microbiota+in+rabbits.&volume=25&issue=8&spage=955&epage=966&date=2019&doi=10.3748%2Fwjg.v25.i8.955&pmid=30833801&sid=OVID:medline
+
+<1754>
+Unique Identifier
+ 30832230
+Title
+ Oral Glutamine Supplementation Reduces Obesity, Pro-Inflammatory Markers, and Improves Insulin Sensitivity in DIO Wistar Rats and Reduces Waist Circumference in Overweight and Obese Humans.
+Source
+ Nutrients. 11(3), 2019 Mar 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abboud KY; Reis SK; Martelli ME; Zordao OP; Tannihao F; de Souza AZZ; Assalin HB; Guadagnini D; Rocha GZ; Saad MJA; Prada PO
+Author NameID
+ Abboud, Kahlile Youssef; ORCID: https://orcid.org/0000-0002-9132-7409
+ Reis, Sabrina Karen; ORCID: https://orcid.org/0000-0003-3967-0792
+ Zordao, Olivia Pizetta; ORCID: https://orcid.org/0000-0003-0596-1954
+ Rocha, Guilherme Zweig; ORCID: https://orcid.org/0000-0002-7403-3230
+Authors Full Name
+ Abboud, Kahlile Youssef; Reis, Sabrina Karen; Martelli, Maria Eduarda; Zordao, Olivia Pizetta; Tannihao, Fabiana; de Souza, Alessandra Zanin Zambom; Assalin, Heloisa Balan; Guadagnini, Dioze; Rocha, Guilherme Zweig; Saad, Mario Jose Abdalla; Prada, Patricia Oliveira.
+Institution
+ Abboud, Kahlile Youssef. School of Applied Sciences, State University of Campinas (UNICAMP), Limeira 13484-350 SP, Brazil. kahlilebbd@gmail.com.
+ Reis, Sabrina Karen. School of Applied Sciences, State University of Campinas (UNICAMP), Limeira 13484-350 SP, Brazil. reis.sabrinakaren@gmail.com.
+ Martelli, Maria Eduarda. School of Applied Sciences, State University of Campinas (UNICAMP), Limeira 13484-350 SP, Brazil. mariaeduardamartelli@hotmail.com.
+ Zordao, Olivia Pizetta. Department of Internal Medicine, State University of Campinas (UNICAMP), Campinas 13083-887 SP, Brazil. oliviapizetta@hotmail.com.
+ Tannihao, Fabiana. School of Applied Sciences, State University of Campinas (UNICAMP), Limeira 13484-350 SP, Brazil. ftannihao@yahoo.com.br.
+ de Souza, Alessandra Zanin Zambom. School of Applied Sciences, State University of Campinas (UNICAMP), Limeira 13484-350 SP, Brazil. alessandrazz@hotmail.com.
+ Assalin, Heloisa Balan. Department of Internal Medicine, State University of Campinas (UNICAMP), Campinas 13083-887 SP, Brazil. helo_assalin@yahoo.com.br.
+ Guadagnini, Dioze. Department of Internal Medicine, State University of Campinas (UNICAMP), Campinas 13083-887 SP, Brazil. diozeg@gmail.com.
+ Rocha, Guilherme Zweig. Department of Internal Medicine, State University of Campinas (UNICAMP), Campinas 13083-887 SP, Brazil. gzrocha@gmail.com.
+ Saad, Mario Jose Abdalla. Department of Internal Medicine, State University of Campinas (UNICAMP), Campinas 13083-887 SP, Brazil. msaad@fcm.unicamp.br.
+ Prada, Patricia Oliveira. School of Applied Sciences, State University of Campinas (UNICAMP), Limeira 13484-350 SP, Brazil. pprada.fca@gmail.com.
+ Prada, Patricia Oliveira. Department of Internal Medicine, State University of Campinas (UNICAMP), Campinas 13083-887 SP, Brazil. pprada.fca@gmail.com.
+MeSH Subject Headings
+ Adult
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight/ph [Physiology]
+ Diet, High-Fat/ae [Adverse Effects]
+ *Dietary Supplements
+ Double-Blind Method
+ Female
+ Glucose Clamp Technique
+ *Glutamine/ad [Administration & Dosage]
+ Humans
+ Inflammation Mediators/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ Liver/me [Metabolism]
+ Male
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Overweight/et [Etiology]
+ Overweight/pp [Physiopathology]
+ *Overweight/th [Therapy]
+ Rats
+ Rats, Wistar
+ Waist Circumference/ph [Physiology]
+Keyword Heading
+ LPS
+ clamp
+ cytokines
+ glutamine supplementation
+ hexosamine
+ inflammation
+ insulin sensitivity
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In the present study, we aimed to investigate whether chronic oral glutamine (Gln) supplementation may alter metabolic parameters and the inflammatory profile in overweight and obese humans as well as whether Gln may modulate molecular pathways in key tissues linked to the insulin action in rats. Thirty-nine overweight/obese volunteers received 30 g of Gln or alanine (Ala-control) for 14 days. Body weight (BW), waist circumference (WC), hormones, and pro-inflammatory markers were evaluated. To investigate molecular mechanisms, Gln or Ala was given to Wistar rats on a high-fat diet (HFD), and metabolic parameters, euglycemic hyperinsulinemic clamp with tracers, and Western blot were done. Gln reduced WC and serum lipopolysaccharide (LPS) in overweight volunteers. In the obese group, Gln diminished WC and serum insulin. There was a positive correlation between the reduction on WC and LPS. In rats on HFD, Gln reduced adiposity, improved insulin action and signaling, and reversed both defects in glucose metabolism in the liver and muscle. Gln supplementation increased muscle glucose uptake and reversed the increased hepatic glucose production, in parallel with a reduced glucose uptake in adipose tissue. This insulin resistance in AT was accompanied by enhanced IRS1 O-linked-glycosamine association in this tissue, but not in the liver and muscle. These data suggest that Gln supplementation leads to insulin resistance specifically in adipose tissue via the hexosamine pathway and reduces adipose mass, which is associated with improvement in the systemic insulin action. Thus, further investigation with Gln supplementation should be performed for longer periods in humans before prescribing as a beneficial therapeutic approach for individuals who are overweight and obese.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 0RH81L854J (Glutamine).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11030536
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abboud&issn=2072-6643&title=Nutrients&atitle=Oral+Glutamine+Supplementation+Reduces+Obesity%2C+Pro-Inflammatory+Markers%2C+and+Improves+Insulin+Sensitivity+in+DIO+Wistar+Rats+and+Reduces+Waist+Circumference+in+Overweight+and+Obese+Humans.&volume=11&issue=3&spage=&epage=&date=2019&doi=10.3390%2Fnu11030536&pmid=30832230&sid=OVID:medline
+
+<1755>
+Unique Identifier
+ 30830428
+Title
+ Trial data of the anti-obesity potential of a high resistant starch diet for canines using Dodamssal rice and the identification of discriminating markers in feces for metabolic profiling.
+Source
+ Metabolomics. 15(2):21, 2019 02 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim YJ; Kim JG; Lee WK; So KM; Kim JK
+Author NameID
+ Kim, Jae Kwang; ORCID: https://orcid.org/0000-0003-2692-5370
+Authors Full Name
+ Kim, Ye Jin; Kim, Jae Geun; Lee, Wan-Kyu; So, Kyoung Min; Kim, Jae Kwang.
+Institution
+ Kim, Ye Jin. Division of Life Sciences, Incheon National University, Yeonsu-gu, Incheon, 22012, Republic of Korea.
+ Kim, Jae Geun. Division of Life Sciences, Incheon National University, Yeonsu-gu, Incheon, 22012, Republic of Korea.
+ Lee, Wan-Kyu. College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, Republic of Korea.
+ So, Kyoung Min. National Institute of Animal Science, Rural Development Administration, Wanju-gun, Jeollabuk-do, 55365, Republic of Korea. ls2273@korea.kr.
+ Kim, Jae Kwang. Division of Life Sciences, Incheon National University, Yeonsu-gu, Incheon, 22012, Republic of Korea. kjkpj@inu.ac.kr.
+MeSH Subject Headings
+ Animals
+ Biomarkers/an [Analysis]
+ Diet
+ *Diet Therapy/mt [Methods]
+ Diet Therapy/ve [Veterinary]
+ Diet, High-Fat
+ Dogs
+ Feces/ch [Chemistry]
+ Gas Chromatography-Mass Spectrometry/mt [Methods]
+ *Metabolome/ph [Physiology]
+ Metabolomics
+ *Obesity/dh [Diet Therapy]
+ Obesity/ve [Veterinary]
+ Oryza/me [Metabolism]
+ Starch
+Keyword Heading
+ Anti-obesity treatment
+ Canine feces
+ Dodamssal rice
+ Metabolic profiling
+ Multivariate analysis
+ Resistant starch
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Dodamssal rice (Oryza sativa L.) includes high levels of resistant starch (RS), which is a source of dietary fiber. Recently, there has been an increase in the prevalence of obesity in canines; however, the information regarding diet treatments for such a condition is inadequate.
+
+ OBJECTIVES: Targeted metabolic profiles in canine feces were performed to identify potential biomarkers of RS and demonstrate the effect and potential use of Dodamssal rice as an anti-obesity treatment.
+
+ METHODS: Study canines were divided into three groups and fed either a regular diet, high-fat diet (HFD), or high-fat diet with Dodamssal rice (DoHFD). Fecal metabolites were analyzed using gas chromatography time-of-flight mass spectrometry and a gas chromatography-flame ionization detector. Multivariate analyses were used to analyze and visualize the obtained data.
+
+ RESULTS: A total of 52 metabolites were detected in the canine feces. In addition, HFD group feces contained a significantly low level of C12:0. The DoHFD group feces had higher levels of 4-aminobutyric acid, glucose, and 3-hydroxybutyric acid compared to the other groups (p < 0.05).
+
+ CONCLUSION: For the first time, targeted metabolic profiling in the canine feces in response to three diets was performed. This metabolic profiling approach should be a useful tool to detect discriminating markers as well as assess the effect of diet compositions for anti-obesity treatment of canines. Furthermore, Dodamssal rice may possibly be used not only for canines, but also to treat obesity in other animals and humans.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 9005-25-8 (Starch).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11306-019-1479-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1573-3882&title=Metabolomics&atitle=Trial+data+of+the+anti-obesity+potential+of+a+high+resistant+starch+diet+for+canines+using+Dodamssal+rice+and+the+identification+of+discriminating+markers+in+feces+for+metabolic+profiling.&volume=15&issue=2&spage=21&epage=&date=2019&doi=10.1007%2Fs11306-019-1479-4&pmid=30830428&sid=OVID:medline
+
+<1756>
+Unique Identifier
+ 30827869
+Title
+ Effects of walk training with self-selected intensity on biochemical markers and anthropometric variables in women with obesity.
+Source
+ Obesity Research & Clinical Practice. 13(2):211-213, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Garavelo JJ; Altimari LR; Gabardo JM; Ferreira-Junior A; Freitas LAG; Buzzachera CF; Esteves JVDC; da Silva SG; de Moraes SMF
+Authors Full Name
+ Garavelo, Joao J; Altimari, Leandro R; Gabardo, Juliano M; Ferreira-Junior, Adalberto; Freitas, Luis A G; Buzzachera, Cosme F; Esteves, Joao V D C; da Silva, Sergio G; de Moraes, Solange M F.
+Institution
+ Garavelo, Joao J. Universidade Estadual de Londrina (UEL), Londrina, Brazil.
+ Altimari, Leandro R. Universidade Estadual de Londrina (UEL), Londrina, Brazil.
+ Gabardo, Juliano M. Universidade Estadual de Londrina (UEL), Londrina, Brazil. Electronic address: julianomgabardo@gmail.com.
+ Ferreira-Junior, Adalberto. Universidade Estadual de Londrina (UEL), Londrina, Brazil.
+ Freitas, Luis A G. Universidade Estadual de Londrina (UEL), Londrina, Brazil.
+ Buzzachera, Cosme F. Universidade Norte do Parana (UNOPAR), Londrina, Brazil.
+ Esteves, Joao V D C. Universidade de Sao Paulo (USP), Sao Paulo, Brazil.
+ da Silva, Sergio G. Universidade Federal do Parana (UFPR), Curitiba, Brazil.
+ de Moraes, Solange M F. Universidade Estadual de Maringa (UEM), Maringa, Brazil.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Exercise Test
+ Exercise Therapy
+ *Exercise Tolerance/ph [Physiology]
+ Female
+ Humans
+ *Lipids/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ Physical Exertion
+ *Walking/ph [Physiology]
+Keyword Heading
+ Lipids
+ Obese women
+ Self-paced
+ Walking
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ To evaluate the effects of 12-weeks of walk training with self-selected intensity on lipid profile and anthropometric variables in women with obesity. Forty-eight women volunteers with obesity were randomly assigned into two training groups: self-selected walking group (SSWG; n=25) and control group (CG; n=23). There was improvement in biochemical markers only in the SSWG post-intervention (p<0.05), however no changes were verified in anthropometric variables (p>0.05). This study demonstrates that walking at self-selected intensity improved the lipid profile in women with obesity. Copyright © 2019 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Letter. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.orcp.2019.02.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Garavelo&issn=1871-403X&title=Obesity+Research+%26+Clinical+Practice&atitle=Effects+of+walk+training+with+self-selected+intensity+on+biochemical+markers+and+anthropometric+variables+in+women+with+obesity.&volume=13&issue=2&spage=211&epage=213&date=2019&doi=10.1016%2Fj.orcp.2019.02.004&pmid=30827869&sid=OVID:medline
+
+<1757>
+Unique Identifier
+ 30825932
+Title
+ Leptin and Adiponectin as markers for preeclampsia in obese pregnant women, a cohort study.
+Source
+ Pregnancy Hypertension. 15:78-83, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Thagaard IN; Hedley PL; Holm JC; Lange T; Larsen T; Krebs L; Christiansen M
+Authors Full Name
+ Thagaard, Ida Naslund; Hedley, Paula L; Holm, Jens-Christian; Lange, Theis; Larsen, Torben; Krebs, Lone; Christiansen, Michael.
+Institution
+ Thagaard, Ida Naslund. Department of Gynecology and Obstetrics, Copenhagen University Hospital Holbaek, Smedelundsgade 60, 4300 Holbaek, Denmark. Electronic address: anna.ida.naeslund.thagaard@regionh.dk.
+ Hedley, Paula L. Department for Congenital Disorders, Danish National Biobank and Biomarkers, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark.
+ Holm, Jens-Christian. The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbaek, Smedelundsgade 60, 4300 Holbaek, Denmark; The Novo Nordisk Foundation Centre for Basic Metabolic Research Section of Metabolic Genetics, University of Copenhagen, Denmark.
+ Lange, Theis. Department of Public Health, Section of Biostatistics, University of Copenhagen, Oster Farimagsgade 5, 1014 Copenhagen K, Denmark.
+ Larsen, Torben. Department of Gynecology and Obstetrics, Copenhagen University Hospital Holbaek, Smedelundsgade 60, 4300 Holbaek, Denmark.
+ Krebs, Lone. Department of Gynecology and Obstetrics, Copenhagen University Hospital Holbaek, Smedelundsgade 60, 4300 Holbaek, Denmark.
+ Christiansen, Michael. Department for Congenital Disorders, Danish National Biobank and Biomarkers, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark; Department of Biomedical Sciences, University of Copenhagen, Denmark.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ Cohort Studies
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ Gestational Age
+ Humans
+ *Leptin/bl [Blood]
+ Logistic Models
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Pre-Eclampsia/bl [Blood]
+ Pre-Eclampsia/et [Etiology]
+ Pregnancy
+ Pregnancy Trimester, First/bl [Blood]
+ Risk Assessment
+ Young Adult
+Keyword Heading
+ Adiponectin
+ Leptin
+ Obesity
+ Preeclampsia
+ Pregnancy
+ Screening
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Preeclampsia (PE) is a serious complication of pregnancy, the pathogenesis of which is largely unknown. We hypothesize that adipocytokines may play a role in the pathogenesis of PE, particularly in obese women, and evaluate leptin and adiponectin as potential first trimester markers for predicting PE.
+
+ STUDY DESIGN: A cohort of 2503 pregnancies, containing 93 PE pregnancies, was divided into women with normal weight, moderate, or severe obesity. All pregnancies had serum adiponectin and leptin measured in first trimester. Logistic regression was used to model PE with maternal characteristics and concentrations of the biomarkers.
+
+ RESULTS: In obese women a lower concentration of adiponectin was found in PE pregnancies; the concentration was lowest in the severely obese (p=0.005). No association was found in normal weight women (p=0.72). Leptin concentration had no association with PE in normal weight and moderately obese (p=0.175-0.072), however in women with severe obesity a lower level of leptin was found (p=0.049). The AUC was 0.73 for the ROC curve of combined maternal characteristics and adiponectin. Using adiponectin in women with moderate to severe obesity the sensitivity was 72.9% and the specificity was 49%.
+
+ CONCLUSIONS: In severely obese women, PE is associated with low serum adiponectin and leptin concentrations in first trimester. This indicates that the inability of adipokine regulation to adapt to severe obesity may play a role in the pathogenesis of PE. Adipocytokines may contribute in identification of risk pregnancies among severe obese. Copyright © 2018 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.preghy.2018.12.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Thagaard&issn=2210-7789&title=Pregnancy+Hypertension&atitle=Leptin+and+Adiponectin+as+markers+for+preeclampsia+in+obese+pregnant+women%2C+a+cohort+study.&volume=15&issue=&spage=78&epage=83&date=2019&doi=10.1016%2Fj.preghy.2018.12.002&pmid=30825932&sid=OVID:medline
+
+<1758>
+Unique Identifier
+ 30824545
+Title
+ Identification of a natural beige adipose depot in mice.
+Source
+ Journal of Biological Chemistry. 294(17):6751-6761, 2019 04 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chan M; Lim YC; Yang J; Namwanje M; Liu L; Qiang L
+Author NameID
+ Chan, Michelle; ORCID: https://orcid.org/0000-0001-6037-7051
+ Qiang, Li; ORCID: https://orcid.org/0000-0001-8322-1797
+Authors Full Name
+ Chan, Michelle; Lim, Yen Ching; Yang, Jing; Namwanje, Maria; Liu, Longhua; Qiang, Li.
+Institution
+ Chan, Michelle. From the Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
+ Chan, Michelle. the Department of Biological Sciences, Columbia University, New York, New York 10027.
+ Lim, Yen Ching. the Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore 169857, Singapore, and.
+ Yang, Jing. From the Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
+ Yang, Jing. the Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an City, Shaanxi Province, China.
+ Namwanje, Maria. From the Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
+ Liu, Longhua. From the Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
+ Qiang, Li. From the Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, lq2123@cumc.columbia.edu.
+MeSH Subject Headings
+ *Adipose Tissue, Beige/ah [Anatomy & Histology]
+ Adipose Tissue, Beige/de [Drug Effects]
+ Adipose Tissue, Beige/me [Metabolism]
+ Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat
+ Hyperplasia/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ PPAR alpha/me [Metabolism]
+ Sequence Analysis, RNA
+ Thiazolidinediones/pd [Pharmacology]
+ Thigh
+ Transcriptome
+Keyword Heading
+ adipocyte
+ adipose tissue
+ beige fat
+ browning
+ metabolic regulation
+ obesity
+ peroxisome proliferator-activated receptor (PPAR)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Beige fat is a potential therapeutic target for obesity and other metabolic diseases due to its inducible brown fat-like functions. Inguinal white adipose tissue (iWAT) can undergo robust brown remodeling with appropriate stimuli and is therefore widely considered as a representative beige fat depot. However, adipose tissues residing in different anatomic depots exhibit a broad range of plasticity, raising the possibility that better beige fat depots with greater plasticity may exist. Here we identified and characterized a novel, naturally-existing beige fat depot, thigh adipose tissue (tAT). Unlike classic WATs, tAT maintains beige fat morphology at room temperature, whereas high-fat diet (HFD) feeding or aging promotes the development of typical WAT features, namely unilocular adipocytes. The brown adipocyte gene expression in tAT is consistently higher than in iWAT under cold exposure, HFD feeding, and rosiglitazone treatment conditions. Our molecular profiling by RNA-Seq revealed up-regulation of energy expenditure pathways and repressed inflammation in tAT relative to eWAT and iWAT. Furthermore, we demonstrated that the master fatty acid oxidation regulator peroxisome proliferator-activated receptor alpha is dispensable for maintaining and activating the beige character of tAT. Therefore, we have identified tAT as a natural beige adipose depot in mice with a unique molecular profile that does not require peroxisome proliferator-activated receptor alpha. Copyright © 2019 Chan et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (PPAR alpha). 0 (Thiazolidinediones).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1074%2fjbc.RA118.006838
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chan&issn=0021-9258&title=Journal+of+Biological+Chemistry&atitle=Identification+of+a+natural+beige+adipose+depot+in+mice.&volume=294&issue=17&spage=6751&epage=6761&date=2019&doi=10.1074%2Fjbc.RA118.006838&pmid=30824545&sid=OVID:medline
+
+<1759>
+Unique Identifier
+ 30823632
+Title
+ Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans.
+Source
+ Nutrients. 11(3), 2019 Mar 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Perkins RK; Miranda ER; Karstoft K; Beisswenger PJ; Solomon TPJ; Haus JM
+Author NameID
+ Karstoft, Kristian; ORCID: https://orcid.org/0000-0002-6596-4199
+ Haus, Jacob M; ORCID: https://orcid.org/0000-0002-8048-2470
+Authors Full Name
+ Perkins, Ryan K; Miranda, Edwin R; Karstoft, Kristian; Beisswenger, Paul J; Solomon, Thomas P J; Haus, Jacob M.
+Institution
+ Perkins, Ryan K. School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA. ryperkin@umich.edu.
+ Miranda, Edwin R. School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA. edwinray@umich.edu.
+ Karstoft, Kristian. Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark. Kristian.Karstoft@regionh.dk.
+ Beisswenger, Paul J. Geisel School of Medicine, Dartmouth College, PreventAGE Healthcare, 16 Cavendish Court, Lebanon, NH 03766, USA. pjb@preventagehealthcare.com.
+ Solomon, Thomas P J. School of Sport, Exercise, and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, West Midlands B15 2TT, UK. t.solomon@bham.ac.uk.
+ Solomon, Thomas P J. Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands B15 2TT, UK. t.solomon@bham.ac.uk.
+ Haus, Jacob M. School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA. jmhaus@umich.edu.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Chromatography, Liquid
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ Glucose Clamp Technique
+ *Glycation End Products, Advanced/me [Metabolism]
+ Healthy Volunteers
+ Humans
+ Hyperglycemia/et [Etiology]
+ *Hyperglycemia/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ *Oxidative Stress/ph [Physiology]
+ Receptor for Advanced Glycation End Products/an [Analysis]
+ *Receptor for Advanced Glycation End Products/me [Metabolism]
+ Renal Elimination/ph [Physiology]
+ Tandem Mass Spectrometry
+Keyword Heading
+ RAGE
+ hyperglycemia
+ inflammation
+ soluble RAGE
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The purpose of this investigation was to evaluate the effects of experimental hyperglycemia on oxidative damage (OX), advanced glycation end products (AGEs), and the receptor for AGEs (RAGE) through an in vivo approach. Obese subjects (n = 10; 31.2 +/- 1.2 kg.m-2; 56 +/- 3 years) underwent 24 h of hyperglycemic clamp (+5.4 mM above basal), where plasma at basal and after 2 h and 24 h of hyperglycemic challenge were assayed for OX (methionine sulfoxide, MetSO, and aminoadipic acid, AAA) and AGE-free adducts (Ne-carboxymethyllysine, CML; Ne-carboxyethyllysine, CEL; glyoxal hydroimidazolone-1, GH-1; methylglyoxal hydroimidazolone-1, MG-H1; and 3-deoxyglucosone hydroimidazolone, 3DG-H) via liquid chromatography-tandem mass spectrometry (LC-MS/MS). Urine was also analyzed at basal and after 24 h for OX and AGE-free adducts and plasma soluble RAGE (sRAGE) isoforms (endogenous secretory RAGE, esRAGE, and cleaved RAGE, cRAGE), and inflammatory markers were determined via enzyme-linked immunosorbent assay (ELISA). Skeletal muscle tissue collected via biopsy was probed at basal, 2 h, and 24 h for RAGE and OST48 protein expression. Plasma MetSO, AAA, CEL, MG-H1, and G-H1 decreased (-18% to -47%; p < 0.05), while CML increased (72% at 24 h; p < 0.05) and 3DG-H remained unchanged (p > 0.05) with the hyperglycemic challenge. Renal clearance of MetSO, AAA, and G-H1 increased (599% to 1077%; p < 0.05), CML decreased (-30%; p < 0.05), and 3DG-H, CEL, and MG-H1 remained unchanged (p > 0.05). Fractional excretion of MetSO, AAA, CEL, G-H1, and MG-H1 increased (5.8% to 532%; p < 0.05) and CML and 3DG-H remained unchanged (p > 0.05). Muscle RAGE and OST48 expression, plasma sRAGE, IL-1beta, IL-1Ra, and TNFalpha remained unchanged (p > 0.05), while IL-6 increased (159% vs. basal; p > 0.05). These findings suggest that individuals who are obese but otherwise healthy have the capacity to prevent accumulation of OX and AGEs during metabolic stress by increasing fractional excretion and renal clearance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycation End Products, Advanced). 0 (Receptor for Advanced Glycation End Products). 0 (esRAGE protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11030532
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Perkins&issn=2072-6643&title=Nutrients&atitle=Experimental+Hyperglycemia+Alters+Circulating+Concentrations+and+Renal+Clearance+of+Oxidative+and+Advanced+Glycation+End+Products+in+Healthy+Obese+Humans.&volume=11&issue=3&spage=&epage=&date=2019&doi=10.3390%2Fnu11030532&pmid=30823632&sid=OVID:medline
+
+<1760>
+Unique Identifier
+ 30822393
+Title
+ Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice.
+Source
+ European Journal of Pharmacology. 854:354-364, 2019 Jul 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shankar K; Kumar D; Gupta S; Varshney S; Rajan S; Srivastava A; Gupta A; Gupta AP; Vishwakarma AL; Gayen JR; Gaikwad AN
+Authors Full Name
+ Shankar, Kripa; Kumar, Durgesh; Gupta, Sanchita; Varshney, Salil; Rajan, Sujith; Srivastava, Ankita; Gupta, Abhishek; Gupta, Anand Prakash; Vishwakarma, Achchhe Lal; Gayen, Jiaur R; Gaikwad, Anil Nilkanth.
+Institution
+ Shankar, Kripa. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
+ Kumar, Durgesh. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
+ Gupta, Sanchita. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, New Delhi 110025, India.
+ Varshney, Salil. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, New Delhi 110025, India.
+ Rajan, Sujith. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, New Delhi 110025, India.
+ Srivastava, Ankita. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, New Delhi 110025, India.
+ Gupta, Abhishek. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
+ Gupta, Anand Prakash. Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, New Delhi 110025, India.
+ Vishwakarma, Achchhe Lal. Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow 226031, India.
+ Gayen, Jiaur R. Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow 226031, India.
+ Gaikwad, Anil Nilkanth. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India. Electronic address: anil_gaikwad@cdri.res.in.
+MeSH Subject Headings
+ Adipose Tissue, Brown/me [Metabolism]
+ Adipose Tissue, Brown/pa [Pathology]
+ *Adipose Tissue, Brown/tr [Transplantation]
+ Animals
+ Biomarkers/me [Metabolism]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Energy Metabolism
+ Gene Expression Regulation
+ Inflammation/pa [Pathology]
+ *Insulin Resistance
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+Keyword Heading
+ Adipose tissue
+ Energy expenditure
+ Inflammation
+ Insulin resistance
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity results in the chronic activation of innate immune system and subsequently sets in diabetes. Aim of the study was to investigate the immunometabolic role of brown adipose tissue (BAT) in the obesity. We performed both BAT transplantation as well as extirpation experiments in the mouse model of high-fat diet (HFD)-induced obesity. We carried out immune cell profiling in the stromal vascular fraction (SVF) isolated from epididymal white adipose tissue (eWAT). BAT transplantation reversed HFD-induced increase in body weight gain and insulin resistance without altering diet intake. Importantly, BAT transplantation attenuated the obesity-associated adipose tissue inflammation in terms of decreased pro-inflammatory M1-macrophages, cytotoxic CD8a T-cells and restored anti-inflammatory regulatory T-cells (Tregs) in the eWAT. BAT transplantation also improved endogenous BAT activity by elevating protein expression of browning markers (UCP-1, PRDM16 and PGC1alpha) in it. In addition, BAT transplantation promoted the eWAT expression of various genes involved in fatty acid oxidation (such as Elvol3 and Tfam,). In contrast, extirpation of the interscapular BAT exacerbated HFD-induced obesity, insulin resistance and adipose tissue inflammation (by increasing M1 macrophages, CD8a T-cell and decreasing Tregs in eWAT). Taken together, our results suggested an important role of BAT in combating obesity-associated metabolic complications. These results open a novel therapeutic option to target obesity and related metabolic disorders like type 2 diabetes. Copyright © 2019 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ejphar.2019.02.044
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shankar&issn=0014-2999&title=European+Journal+of+Pharmacology&atitle=Role+of+brown+adipose+tissue+in+modulating+adipose+tissue+inflammation+and+insulin+resistance+in+high-fat+diet+fed+mice.&volume=854&issue=&spage=354&epage=364&date=2019&doi=10.1016%2Fj.ejphar.2019.02.044&pmid=30822393&sid=OVID:medline
+
+<1761>
+Unique Identifier
+ 30821134
+Title
+ Acute and chronic effect of bariatric surgery on circulating autotaxin levels.
+Source
+ Physiological Reports. 7(5):e14004, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bourgeois R; Piche ME; Auclair A; Grenier-Larouche T; Mitchell PL; Poirier P; Biertho L; Marceau S; Hould FS; Biron S; Lebel S; Lescelleur O; Julien F; Martin J; Tchernof A; Mathieu P; Carpentier AC; Arsenault BJ
+Author NameID
+ Arsenault, Benoit J; ORCID: https://orcid.org/0000-0003-2240-8456
+Authors Full Name
+ Bourgeois, Raphaelle; Piche, Marie-Eve; Auclair, Audrey; Grenier-Larouche, Thomas; Mitchell, Patricia L; Poirier, Paul; Biertho, Laurent; Marceau, Simon; Hould, Frederic-Simon; Biron, Simon; Lebel, Stefane; Lescelleur, Odette; Julien, Francois; Martin, Julie; Tchernof, Andre; Mathieu, Patrick; Carpentier, Andre C; Arsenault, Benoit J.
+Institution
+ Bourgeois, Raphaelle. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Bourgeois, Raphaelle. Department of Medicine, Faculty of Medicine, Universite Laval, Quebec, Canada.
+ Piche, Marie-Eve. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Piche, Marie-Eve. Department of Medicine, Faculty of Medicine, Universite Laval, Quebec, Canada.
+ Auclair, Audrey. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Grenier-Larouche, Thomas. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Mitchell, Patricia L. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Poirier, Paul. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Poirier, Paul. Faculty of Pharmacy, Universite Laval, Quebec, Canada.
+ Biertho, Laurent. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Marceau, Simon. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Hould, Frederic-Simon. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Biron, Simon. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Lebel, Stefane. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Lescelleur, Odette. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Julien, Francois. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Martin, Julie. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Tchernof, Andre. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Tchernof, Andre. School of Nutrition, Universite Laval, Quebec, Canada.
+ Mathieu, Patrick. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Mathieu, Patrick. Department of Surgery, Faculty of Medicine, Universite Laval, Quebec, Canada.
+ Carpentier, Andre C. Department of Medicine, Division of Endocrinology, Centre de recherche du CHUS, Universite de Sherbrooke, Canada.
+ Arsenault, Benoit J. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Quebec, Quebec, Canada.
+ Arsenault, Benoit J. Department of Medicine, Faculty of Medicine, Universite Laval, Quebec, Canada.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Bariatric Surgery/ae [Adverse Effects]
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Caloric Restriction
+ Case-Control Studies
+ Down-Regulation
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/su [Surgery]
+ *Phosphoric Diester Hydrolases/bl [Blood]
+ Severity of Illness Index
+ Time Factors
+ Treatment Outcome
+ Weight Loss
+Keyword Heading
+ Autotaxin
+ bariatric surgery
+ caloric restriction
+ obesity
+ sex
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Autotaxin (ATX), an adipose tissue-derived lysophospholipase, has been involved in the pathophysiology of cardiometabolic diseases. The impact of bariatric surgery on circulating ATX levels is unknown. We examined the short- (24 h, 5 days) and longer-term (6 and 12 months) impact of bariatric surgery; as well as the short-term effect of caloric restriction (CR) on plasma ATX levels in patients with severe obesity. We measured ATX levels in 69 men and women (mean age: 41 +/- 11 years, body mass index: 49.8 +/- 7.1 kg/m2 ), before and after biliopancreatic diversion with duodenal switch surgery (BPD-DS) as well as in a control group (patients with severe obesity without surgery; n = 34). We also measured ATX levels in seven patients with severe obesity and type 2 diabetes who underwent a 3-day CR protocol before their BPD-DS. At baseline, ATX levels were positively associated with body mass index, fat mass, insulin resistance (HOMA-IR) as well as insulin and leptin levels and negatively with fat-free mass. ATX concentrations decreased 26.2% at 24 h after BPD-DS (342.9 +/- 152.3 pg/mL to 253.2 +/- 68.9 pg/mL, P < 0.0001) and by 16.4% at 12 months after BPD-DS (342.9 +/- 152.3 pg/mL to 286.8 +/- 182.6 pg/mL, P = 0.04). ATX concentrations were unchanged during follow-up in the control group (P = 0.4), and not influenced by short-term CR. In patients with severe obesity, bariatric surgery induced a rapid and sustained decrease in plasma ATX levels. Acute changes in ATX may not be explained by bariatric surgery-induced CR. Copyright © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-1-4 (Phosphoric Diester Hydrolases). EC 3-1-4-39 (alkylglycerophosphoethanolamine phosphodiesterase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.14814%2fphy2.14004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bourgeois&issn=2051-817X&title=Physiological+Reports&atitle=Acute+and+chronic+effect+of+bariatric+surgery+on+circulating+autotaxin+levels.&volume=7&issue=5&spage=e14004&epage=&date=2019&doi=10.14814%2Fphy2.14004&pmid=30821134&sid=OVID:medline
+
+<1762>
+Unique Identifier
+ 30814081
+Title
+ Complement Component 3 as a Surrogate Hallmark for Metabolic Abnormalities in Patients with Chronic Hepatitis C.
+Source
+ Annals of Clinical & Laboratory Science. 49(1):79-88, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Himoto T; Hirakawa E; Fujita K; Sakamoto T; Nomura T; Morishita A; Yoneyama H; Haba R; Masaki T
+Authors Full Name
+ Himoto, Takashi; Hirakawa, Eiichiro; Fujita, Koji; Sakamoto, Teppei; Nomura, Takako; Morishita, Asahiro; Yoneyama, Hirohito; Haba, Reiji; Masaki, Tsutomu.
+Institution
+ Himoto, Takashi. Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Kagawa, Japan.
+ Hirakawa, Eiichiro. Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Kagawa, Japan.
+ Fujita, Koji. Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan.
+ Sakamoto, Teppei. Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan.
+ Nomura, Takako. Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan.
+ Morishita, Asahiro. Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan.
+ Yoneyama, Hirohito. Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan.
+ Haba, Reiji. Department of Diagnosis Pathology, Kagawa University School of Medicine, Kagawa, Japan.
+ Masaki, Tsutomu. Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan himoto@chs.pref.kagawa.jp.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/me [Metabolism]
+ Body Mass Index
+ *Complement C3/me [Metabolism]
+ *Fatty Liver/di [Diagnosis]
+ Fatty Liver/et [Etiology]
+ Fatty Liver/me [Metabolism]
+ Female
+ Hepacivirus/ip [Isolation & Purification]
+ *Hepatitis C, Chronic/co [Complications]
+ Hepatitis C, Chronic/vi [Virology]
+ Humans
+ *Insulin Resistance
+ *Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/et [Etiology]
+ Liver Cirrhosis/me [Metabolism]
+ Male
+ Middle Aged
+ *Obesity/di [Diagnosis]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Prognosis
+ Severity of Illness Index
+Keyword Heading
+ complement component 3
+ hepatic steatosis
+ hepatitis C virus
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: We investigated the correlation between serum complement component 3 (C3) levels and metabolic and histological abnormalities in patients with chronic hepatitis C (CH-C).
+
+ METHODS: Obesity and insulin resistance were estimated by calculating body mass index (BMI) and the values of the homeostasis model for assessment of insulin resistance (HOMA-IR), respectively. Severity of hepatic steatosis and fibrosis were evaluated by New Inuyama Classification and the classification proposed by Brunt and colleagues, respectively. The degree of hepatic C3 expression was examined, using an immunohistochemical procedure.
+
+ RESULTS: Serum C3 levels were significantly correlated with BMI, HOMA-IR value, and serum triglyceride levels in CH-C patients. Histological analysis revealed that serum C3 levels were significantly elevated in proportion to the severity of hepatic steatosis in such patients. The serum C3 level tended to increase as the severity of hepatic fibrosis progressed. However, the degree of C3 expression in hepatocytes was not associated with serum C3 level among those patients.
+
+ CONCLUSIONS: These results suggest that the elevation of serum C3 levels may reflect obesity, insulin resistance, and/or hepatic steatosis in patients with CH-C, and that the increase in the synthesis of C3 may derive from the activation of cells other than hepatocytes in those patients. Copyright © 2019 by the Association of Clinical Scientists, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C3 protein, human). 0 (Complement C3).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&AN=30814081
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Himoto&issn=0091-7370&title=Annals+of+Clinical+%26+Laboratory+Science&atitle=Complement+Component+3+as+a+Surrogate+Hallmark+for+Metabolic+Abnormalities+in+Patients+with+Chronic+Hepatitis+C.&volume=49&issue=1&spage=79&epage=88&date=2019&doi=&pmid=30814081&sid=OVID:medline
+
+<1763>
+Unique Identifier
+ 30813240
+Title
+ Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation.
+Source
+ Nutrients. 11(2), 2019 Feb 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fruhbeck G; Catalan V; Rodriguez A; Ramirez B; Becerril S; Salvador J; Colina I; Gomez-Ambrosi J
+Author NameID
+ Fruhbeck, Gema; ORCID: https://orcid.org/0000-0002-8305-7154
+ Gomez-Ambrosi, Javier; ORCID: https://orcid.org/0000-0001-5601-1604
+Authors Full Name
+ Fruhbeck, Gema; Catalan, Victoria; Rodriguez, Amaia; Ramirez, Beatriz; Becerril, Sara; Salvador, Javier; Colina, Inmaculada; Gomez-Ambrosi, Javier.
+Institution
+ Fruhbeck, Gema. Metabolic Research Laboratory, Clinica Universidad de Navarra, 31008 Pamplona, Spain. gfruhbeck@unav.es.
+ Fruhbeck, Gema. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain. gfruhbeck@unav.es.
+ Fruhbeck, Gema. Obesity and Adipobiology Group, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. gfruhbeck@unav.es.
+ Fruhbeck, Gema. Department of Endocrinology & Nutrition, Clinica Universidad de Navarra, 31008 Pamplona, Spain. gfruhbeck@unav.es.
+ Catalan, Victoria. Metabolic Research Laboratory, Clinica Universidad de Navarra, 31008 Pamplona, Spain. vcatalan@unav.es.
+ Catalan, Victoria. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain. vcatalan@unav.es.
+ Catalan, Victoria. Obesity and Adipobiology Group, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. vcatalan@unav.es.
+ Rodriguez, Amaia. Metabolic Research Laboratory, Clinica Universidad de Navarra, 31008 Pamplona, Spain. arodmur@unav.es.
+ Rodriguez, Amaia. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain. arodmur@unav.es.
+ Rodriguez, Amaia. Obesity and Adipobiology Group, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. arodmur@unav.es.
+ Ramirez, Beatriz. Metabolic Research Laboratory, Clinica Universidad de Navarra, 31008 Pamplona, Spain. bearamirez@unav.es.
+ Ramirez, Beatriz. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain. bearamirez@unav.es.
+ Ramirez, Beatriz. Obesity and Adipobiology Group, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. bearamirez@unav.es.
+ Becerril, Sara. Metabolic Research Laboratory, Clinica Universidad de Navarra, 31008 Pamplona, Spain. sbecman@unav.es.
+ Becerril, Sara. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain. sbecman@unav.es.
+ Becerril, Sara. Obesity and Adipobiology Group, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. sbecman@unav.es.
+ Salvador, Javier. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain. jsalvador@unav.es.
+ Salvador, Javier. Department of Endocrinology & Nutrition, Clinica Universidad de Navarra, 31008 Pamplona, Spain. jsalvador@unav.es.
+ Colina, Inmaculada. Obesity and Adipobiology Group, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. icolina@unav.es.
+ Colina, Inmaculada. Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain. icolina@unav.es.
+ Gomez-Ambrosi, Javier. Metabolic Research Laboratory, Clinica Universidad de Navarra, 31008 Pamplona, Spain. jagomez@unav.es.
+ Gomez-Ambrosi, Javier. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain. jagomez@unav.es.
+ Gomez-Ambrosi, Javier. Obesity and Adipobiology Group, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. jagomez@unav.es.
+MeSH Subject Headings
+ *Adiponectin/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers
+ Cross-Sectional Studies
+ Female
+ Humans
+ Inflammation/di [Diagnosis]
+ *Inflammation/me [Metabolism]
+ *Leptin/me [Metabolism]
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+ Young Adult
+Keyword Heading
+ adiponectin/leptin ratio
+ adipose tissue
+ inflammation
+ metabolic syndrome
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio has been suggested as a maker of dysfunctional adipose tissue. We aimed to investigate in humans (n = 292) the reliability of the Adpn/Lep ratio as a biomarker of adipose tissue dysfunction. We considered that an Adpn/Lep ratio of >=1.0 can be considered normal, a ratio of >=0.5 <1.0 suggests moderate-medium increased risk, and a ratio of <0.5 indicates a severe increase in cardiometabolic risk. Using these cut-offs, 5%, 54% and 48% of the lean, normoglycemic and without-MS subjects, respectively, fall within the group with an Adpn/Lep ratio below 0.5; while 89%, 86% and 90% of the obese, with T2D and with MS patients fall within the same group (p < 0.001). A significant negative correlation (r = -0.21, p = 0.005) between the Adpn/Lep ratio and serum amyloid A (SAA) concentrations, a marker of adipose tissue dysfunction, was found. We concluded that the Adpn/Lep ratio is a good indicator of a dysfunctional adipose tissue that may be a useful estimator of obesity- and MS-associated cardiometabolic risk, allowing the identification of a higher number of subjects at risk.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11020454
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fruhbeck&issn=2072-6643&title=Nutrients&atitle=Adiponectin-leptin+Ratio+is+a+Functional+Biomarker+of+Adipose+Tissue+Inflammation.&volume=11&issue=2&spage=&epage=&date=2019&doi=10.3390%2Fnu11020454&pmid=30813240&sid=OVID:medline
+
+<1764>
+Unique Identifier
+ 30811247
+Title
+ Early treatment with GLP-1 after severe trauma preserves renal function in obese Zucker rats.
+Source
+ American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 316(5):R621-R627, 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xiang L; Thompson MS; Clemmer JS; Mittwede PN; Khan T; Hester RL
+Author NameID
+ Clemmer, John S; ORCID: https://orcid.org/0000-0003-2250-2960
+Authors Full Name
+ Xiang, Lusha; Thompson, Michael S; Clemmer, John S; Mittwede, Peter N; Khan, Tazim; Hester, Robert L.
+Institution
+ Xiang, Lusha. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
+ Xiang, Lusha. United States Army Institute of Surgical Research, San Antonio, Texas.
+ Thompson, Michael S. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
+ Clemmer, John S. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
+ Mittwede, Peter N. Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
+ Khan, Tazim. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
+ Hester, Robert L. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
+MeSH Subject Headings
+ Acute Kidney Injury/et [Etiology]
+ Acute Kidney Injury/pp [Physiopathology]
+ *Acute Kidney Injury/pc [Prevention & Control]
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ Disease Models, Animal
+ *Fractures, Bone/co [Complications]
+ Glomerular Filtration Rate/de [Drug Effects]
+ *Glucagon-Like Peptide 1/pd [Pharmacology]
+ Hyperglycemia/bl [Blood]
+ *Hyperglycemia/dt [Drug Therapy]
+ Hyperglycemia/et [Etiology]
+ *Hypoglycemic Agents/pd [Pharmacology]
+ Insulin Resistance
+ *Kidney/de [Drug Effects]
+ Kidney/me [Metabolism]
+ Kidney/pp [Physiopathology]
+ Male
+ *Obesity/co [Complications]
+ Oxygen Consumption/de [Drug Effects]
+ Rats, Zucker
+ *Soft Tissue Injuries/co [Complications]
+ Time Factors
+Keyword Heading
+ glycogen-like peptide-1
+ hemodynamics
+ hyperglycemia
+ kidney injury
+ obesity
+ oxygenation
+ trauma
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Early posttrauma hyperglycemia (EPTH) is correlated with later adverse outcomes, including acute kidney injury (AKI). Controlling EPTH in the prehospital setting is difficult because of the variability in the ideal insulin dosage and the potential risk of hypoglycemia, especially in those with confounding medical comorbidities of obesity and insulin resistance. Glucagon-like peptide-1 (GLP-1) controls glucose levels in a glucose-dependent manner and is a current target in antidiabetic therapy. We have shown that after orthopedic trauma, obese Zucker rats exhibit EPTH and a later development of AKI (within 24 h). We hypothesized that GLP-1 treatment after trauma decreases EPTH and protects renal function in obese Zucker rats. Obese Zucker rats (~12 wk old) were fasted for 4 h before trauma. Soft tissue injury, fibula fracture, and homogenized bone component injection were then performed in both hind limbs to induce severe extremity trauma. Plasma glucose levels were measured before and 15, 30, 60, 120, 180, 240, and 300 min after trauma. GLP-1 (3 mug.kg-1.h-1, 1.5 ml/kg total) or saline was continuously infused from 30 min to 5 h after trauma. Afterwards, rats were placed in metabolic cages overnight for urine collection. The following day, plasma interleukin (IL)-6 levels, renal blood flow (RBF), glomerular filtration rate (GFR), and renal oxygen delivery (Do2) and consumption (Vo2) were measured. EPTH was evident within 15 min after trauma but was significantly ameliorated during the 5 h of GLP-1 infusion. One day after trauma, plasma IL-6 was markedly increased in the trauma group and decreased in GLP-1-treated animals. RBF, GFR, and Do2 all significantly decreased with trauma, but renal Vo2 was unchanged. GLP-1 treatment normalized RBF, GFR, and Do2 without affecting Vo2. These results suggest that GLP-1 decreases EPTH and protects against a later development of AKI. Early treatment with GLP-1 (or its analogs) to rapidly, effectively, and safely control EPTH may be beneficial in the prehospital care of obese patients after trauma.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Hypoglycemic Agents). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1152%2fajpregu.00312.2018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xiang&issn=0363-6119&title=American+Journal+of+Physiology+-+Regulatory+Integrative+%26+Comparative+Physiology&atitle=Early+treatment+with+GLP-1+after+severe+trauma+preserves+renal+function+in+obese+Zucker+rats.&volume=316&issue=5&spage=R621&epage=R627&date=2019&doi=10.1152%2Fajpregu.00312.2018&pmid=30811247&sid=OVID:medline
+
+<1765>
+Unique Identifier
+ 30810500
+Title
+ Influence of Weight Reduction and Enhanced Protein Intake on Biomarkers of Inflammation in Older Adults with Obesity.
+Source
+ Journal of Nutrition in Gerontology & Geriatrics. 38(1):33-49, 2019 Jan-Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Porter Starr KN; Orenduff M; McDonald SR; Mulder H; Sloane R; Pieper CF; Bales CW
+Authors Full Name
+ Porter Starr, Kathryn N; Orenduff, Melissa; McDonald, Shelley R; Mulder, Hillary; Sloane, Richard; Pieper, Carl F; Bales, Connie W.
+Institution
+ Porter Starr, Kathryn N. a Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA.
+ Porter Starr, Kathryn N. b Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA.
+ Porter Starr, Kathryn N. c Department of Medicine, Duke University Medical Center, Durham, NC, USA.
+ Orenduff, Melissa. a Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA.
+ McDonald, Shelley R. a Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA.
+ McDonald, Shelley R. b Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA.
+ McDonald, Shelley R. c Department of Medicine, Duke University Medical Center, Durham, NC, USA.
+ Mulder, Hillary. d Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
+ Sloane, Richard. a Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA.
+ Sloane, Richard. d Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
+ Pieper, Carl F. a Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA.
+ Pieper, Carl F. d Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
+ Bales, Connie W. a Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA.
+ Bales, Connie W. b Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA.
+ Bales, Connie W. d Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Diet, Reducing
+ *Dietary Proteins/ad [Administration & Dosage]
+ Female
+ Frail Elderly
+ Humans
+ *Inflammation/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/dh [Diet Therapy]
+ Sarcopenia/dh [Diet Therapy]
+ *Weight Loss
+Keyword Heading
+ Inflammation
+ obesity
+ older adults
+ protein intake
+ weight reduction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Both aging and obesity are associated with increased levels of pro-inflammatory metabolites, while weight reduction is associated with improvements in inflammatory status. However, few studies have explored the response of key inflammatory markers to the combined settings of weight reduction in an aging population. There are also few studies that have investigated the potential impact of diet composition on inflammatory marker responses. In the MEASUR-UP trial, we evaluated changes in baseline levels of inflammatory markers with post-study levels for a traditional weight loss control group versus a group with generous, balanced protein intake. In this 6-month randomized controlled trial (RCT), older (>=60 years) adults with obesity (BMI >=30 kg/m2) and Short Physical Performance Battery (SPPB) score of 4-10 were randomly assigned to either a traditional weight loss regimen, (Control, n = 14) or one with higher protein intake (>=30 g) at each meal (Protein, n = 25). All participants were prescribed a hypo-caloric diet and attended weekly support and education groups and weigh-ins. Protein participants consumed >=30 g of high-quality protein/meal, including lean and extra lean beef provided to them for two of the three meals per day. Protein intakes were 0.8 and 1.2 g/kg/day for Control and Protein, respectively. Adiponectin, leptin, C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, IL-8, serum amyloid A (SAA), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and glycated serum protein (GSP) levels were measured at 0 and 6-month time points. At the 6-month endpoint, there was significant weight loss and decrease in BMI in both the Control (-4.8 +/- 8.2 kg; -2.3 +/- 2.4 kg/m2; p = 0.05) and Protein (-8.7 +/- 7.4 kg; -2.9 +/- 2.3 kg/m2; p < 0.0001) groups. SPPB scores improved in both arms, with a superior functional response in Protein (p < 0.05). Body fat (%) at baseline was positively correlated with leptin, hs-CRP, VCAM-1, ICAM-1, and GSP. Several markers of inflammation responded to the Protein group: leptin (p < 0.001), hs-CRP (p < 0.01), and ICAM-1 (p < 0.01) were decreased and adiponectin increased (p < 0.01). There were no significant changes in any inflammatory markers in the Control arm. In the between group comparison, only adiponectin trended towards a group difference (more improvement in Protein; p < 0.07). Our findings in the MEASUR-UP trial show that a weight loss diet with enhanced protein intake is comparable to an adequate protein diet in terms of weight loss success and that it can lead to improvements in inflammatory status, specifically for adiponectin, leptin, hs-CRP, and ICAM-1. These findings are important given current recommendations for higher protein intakes in older adults and justify the additional study of the inflammatory impact of an enhanced protein diet. (ClinicalTrials.gov identifier: NCT01715753).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Proteins).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f21551197.2018.1564200
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Porter+Starr&issn=2155-1200&title=Journal+of+Nutrition+in+Gerontology+%26+Geriatrics&atitle=Influence+of+Weight+Reduction+and+Enhanced+Protein+Intake+on+Biomarkers+of+Inflammation+in+Older+Adults+with+Obesity.&volume=38&issue=1&spage=33&epage=49&date=2019&doi=10.1080%2F21551197.2018.1564200&pmid=30810500&sid=OVID:medline
+
+<1766>
+Unique Identifier
+ 30802456
+Title
+ Association between obesity and biomarkers of inflammation and metabolism with cancer mortality in a prospective cohort study.
+Source
+ Metabolism: Clinical & Experimental. 94:69-76, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dibaba DT; Judd SE; Gilchrist SC; Cushman M; Pisu M; Safford M; Akinyemiju T
+Authors Full Name
+ Dibaba, Daniel T; Judd, Suzanne E; Gilchrist, Susan C; Cushman, Mary; Pisu, Maria; Safford, Monika; Akinyemiju, Tomi.
+Institution
+ Dibaba, Daniel T. Department of Epidemiology, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA.
+ Judd, Suzanne E. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Gilchrist, Susan C. Department of Clinical Cancer Prevention and Cardiology, University of Texas MD, Anderson Cancer Center, Houston, TX, USA.
+ Cushman, Mary. Department of Medicine, University of Vermont Cancer Center, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
+ Pisu, Maria. Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
+ Safford, Monika. Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
+ Akinyemiju, Tomi. Department of Epidemiology, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA; Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA. Electronic address: tomi.akinyemiju@duke.edu.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/me [Metabolism]
+ Cohort Studies
+ Female
+ Humans
+ *Inflammation
+ Male
+ Middle Aged
+ *Neoplasms/mo [Mortality]
+ Neoplasms/pa [Pathology]
+ *Obesity/co [Complications]
+ Prospective Studies
+ Risk Factors
+Keyword Heading
+ Cancer mortality
+ Inflammatory cytokines
+ Metabolic biomarkers
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To investigate the association between biomarkers of inflammation and metabolic dysregulation and cancer mortality by obesity status.
+
+ METHODS: Data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was used to examine the associations between baseline biomarkers of inflammation (IL-6, IL-8, IL-10, and CRP) and metabolism (adiponectin, resisting and lipoprotein (a)) with cancer mortality among 1822 participants cancer-free at baseline. Weighted Cox proportional hazard regression with the robust sandwich method was used to estimate the hazard ratios and 95% confidence intervals (CIs) adjusting for baseline covariates and stratified by BMI (normal, overweight/obese) given the significant interaction between biomarkers and BMI (p<0.1).
+
+ RESULTS: During a mean follow-up of 8years, there were statistically significant associations between cancer mortality and being in the highest vs. lowest tertile of IL-6 (HR: 5.3; 95% CI: 1.6, 17.8), CRP (HR: 3.4; 95% CI: 1.0, 11.2) and resistin (HR: 3.7; 95% CI: 1.2, 11.2) among participants with normal BMI. IL-6 was also associated with a 3-fold (HR: 3.5; 95% CI: 1.5, 8.1) increased risk of cancer mortality among participants with overweight/obesity; however, neither CRP nor resistin was significantly associated with cancer mortality in this group.
+
+ CONCLUSIONS: Higher baseline inflammatory and metabolic biomarkers were associated with significantly increased risk of cancer mortality after adjusting for baseline risk factors and the associations varied by BMI. Cancer patients may benefit from interventions that modulate inflammatory and metabolic biomarkers. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.metabol.2019.01.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dibaba&issn=0026-0495&title=Metabolism%3A+Clinical+%26+Experimental&atitle=Association+between+obesity+and+biomarkers+of+inflammation+and+metabolism+with+cancer+mortality+in+a+prospective+cohort+study.&volume=94&issue=&spage=69&epage=76&date=2019&doi=10.1016%2Fj.metabol.2019.01.007&pmid=30802456&sid=OVID:medline
+
+<1767>
+Unique Identifier
+ 30791536
+Title
+ Pulmonary Hypertension and Obesity: Focus on Adiponectin. [Review]
+Source
+ International Journal of Molecular Sciences. 20(4), 2019 Feb 20.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Perrotta F; Nigro E; Mollica M; Costigliola A; D'Agnano V; Daniele A; Bianco A; Guerra G
+Author NameID
+ Perrotta, Fabio; ORCID: https://orcid.org/0000-0002-7223-7037
+ Daniele, Aurora; ORCID: https://orcid.org/0000-0002-9085-9737
+Authors Full Name
+ Perrotta, Fabio; Nigro, Ersilia; Mollica, Mariano; Costigliola, Adriano; D'Agnano, Vito; Daniele, Aurora; Bianco, Andrea; Guerra, Germano.
+Institution
+ Perrotta, Fabio. Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via Francesco De Sanctis, 86100 Campobasso, Italy. fabio.perrotta@unimol.it.
+ Nigro, Ersilia. Lungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK. e.nigro@ucl.ac.uk.
+ Nigro, Ersilia. Department of Translational Medical Sciences, University of Campania "L. Vanvitelli"/Hosp. Monaldi, 80131 Naples, Italy. e.nigro@ucl.ac.uk.
+ Mollica, Mariano. Department of Translational Medical Sciences, University of Campania "L. Vanvitelli"/Hosp. Monaldi, 80131 Naples, Italy. mollicamariano@gmail.com.
+ Costigliola, Adriano. Department of Translational Medical Sciences, University of Campania "L. Vanvitelli"/Hosp. Monaldi, 80131 Naples, Italy. adriano.costigliola@studenti.unicampania.it.
+ D'Agnano, Vito. Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via Francesco De Sanctis, 86100 Campobasso, Italy. v.dagnano@studenti.unimol.it.
+ Daniele, Aurora. Dipartimento di Scienze e Tecnologie Ambientali, Biologiche, Farmaceutiche, Universita della Campania "Luigi Vanvitelli", 81100 Caserta, Italy. aurora.daniele@unicampania.it.
+ Daniele, Aurora. CEINGE-Biotecnologie avanzate, 80145 Naples, Italy. aurora.daniele@unicampania.it.
+ Bianco, Andrea. Department of Translational Medical Sciences, University of Campania "L. Vanvitelli"/Hosp. Monaldi, 80131 Naples, Italy. andrea.bianco@unicampania.it.
+ Guerra, Germano. Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via Francesco De Sanctis, 86100 Campobasso, Italy. germano.guerra@unimol.it.
+MeSH Subject Headings
+ Adiponectin/ai [Antagonists & Inhibitors]
+ Adiponectin/ge [Genetics]
+ Adiponectin/me [Metabolism]
+ Animals
+ Biomarkers
+ Disease Susceptibility
+ Humans
+ Hypertension, Pulmonary/dt [Drug Therapy]
+ *Hypertension, Pulmonary/et [Etiology]
+ Hypertension, Pulmonary/me [Metabolism]
+ Hypertension, Pulmonary/pp [Physiopathology]
+ Molecular Targeted Therapy
+ Myocytes, Smooth Muscle/me [Metabolism]
+ *Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Signal Transduction
+Keyword Heading
+ adipocytokine
+ adiponectin
+ obesity
+ pulmonary hypertension
+ vascular smooth muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pulmonary hypertension is an umbrella term including many different disorders causing an increase of the mean pulmonary arterial pressure (mPAP) >= 25 mmHg. Recent data revealed a strong association between obesity and pulmonary hypertension. Adiponectin is a protein synthetized by the adipose tissue with pleiotropic effects on inflammation and cell proliferation, with a potential protective role on the pulmonary vasculature. Both in vivo and in vitro studies documented that adiponectin is an endogenous modulator of NO production and interferes with AMP-activated protein kinase (AMPK) activation, mammalian target of rapamycin (mTOR), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappabeta) signaling preventing endothelial dysfunction and proliferation. Furthermore, adiponectin ameliorates insulin resistance by mediating the biological effects of peroxisome proliferator-activated receptor-gamma (PPARgamma). Therefore, adiponectin modulation emerged as a theoretical target for the treatment of pulmonary hypertension, currently under investigation. Recently, consistent data showed that hypoglycemic agents targeting PPARgamma as well as renin-angiotensin system inhibitors and mineralocorticoid receptor blockers may influence pulmonary hemodynamics in different models of pulmonary hypertension.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20040912
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Perrotta&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Pulmonary+Hypertension+and+Obesity%3A+Focus+on+Adiponectin.&volume=20&issue=4&spage=912&epage=&date=2019&doi=10.3390%2Fijms20040912&pmid=30791536&sid=OVID:medline
+
+<1768>
+Unique Identifier
+ 30782162
+Title
+ Trend of various adiposity indices in women with and without history of gestational diabetes: a population-based cohort study.
+Source
+ BMC Endocrine Disorders. 19(1):24, 2019 Feb 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Behboudi-Gandevani S; Ramezani Tehrani F; Rahmati M; Amiri M; Azizi F
+Author NameID
+ Ramezani Tehrani, Fahimeh; ORCID: http://orcid.org/0000-0002-4609-065X
+Authors Full Name
+ Behboudi-Gandevani, Samira; Ramezani Tehrani, Fahimeh; Rahmati, Maryam; Amiri, Mina; Azizi, Fereidoun.
+Institution
+ Behboudi-Gandevani, Samira. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Ramezani Tehrani, Fahimeh. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ramezani@endocrine.ac.ir.
+ Rahmati, Maryam. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Rahmati, Maryam. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
+ Amiri, Mina. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Azizi, Fereidoun. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, Tehran, Iran.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ *Biomarkers/an [Analysis]
+ *Blood Glucose/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ *Diabetes, Gestational/ep [Epidemiology]
+ Diabetes, Gestational/me [Metabolism]
+ Diabetes, Gestational/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Lipids/an [Analysis]
+ Longitudinal Studies
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Pregnancy
+ Prognosis
+ Young Adult
+Keyword Heading
+ Adiposity indices
+ Gestational diabetes
+ Obesity
+ Tehran lipid and glucose study (TLGS)
+ Trend
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Data of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of adiposity indices in women with and without history of GDM, using data of the long term longitudinal population-based Tehran-Lipid and Glucose-Study (TLGS).
+
+ METHODS: A total of 3395 eligible women aged (20-50 years), including 801 women with prior history of GDM and 2594 non-GDM controls were recruited from among Tehran-Lipid and Glucose-Study participants. Generalized estimating equations were applied to assess the time trend of adiposity indices including obesity, central obesity, body mass index (BMI), lipid accumulation product index (LAP), visceral adiposity index (VAI) and a body shape index (ABSI) in women with prior GDM and the non-GDM groups after further adjustment for age and BMI.
+
+ RESULTS: Median follow-up years for the GDM and non-GDM groups were 12.12 and 11.62 years, respectively. Women with GDM at initiation had worse adiposity indices than their healthy counterparts. While overall odds of obesity in women with prior GDM were significantly higher those of the non-GDM groups (OR: 1.35; 95% CI, 1.03-1.7; P = 0.03), both these groups overtime revealed a positive trend in obesity (P trend < 0.001), an incremental trend which was less pronounced in GDM women (OR: 0.87; 95% CI, 0.80, 0.95; P interaction = 0.001). Women with prior GDM had higher odds of central obesity, compared to non-GDM groups (OR: 1.44; 95% CI, 1.06-1.96; P = 0.02) and showed a significant an incremental trend overtime for both groups (P trend < 0.001 for both) without statistically significant interaction in terms of their GDM status (P interaction = 0.134). Mean VAI in women with prior GDM was significantly higher than the non-GDM group (19.7, 95%CI: 6.24, 33.15, P = 0.004), although both groups overtime experienced a negative trend (- 10.9, 95%CI: -13.1, - 2.1, P < 0.001); the GDM group showed a higher decrease in VAI (mean changes: -6.62; 95% CI, - 11,-2.1; P interaction = 0.001). However overtime there was a positive trend in LAP and ABSI among both women with and without prior-GDM, though the mean changes were less obvious in women with prior GDM.
+
+ CONCLUSION: Women with prior GDM gained better control of their adiposity than non-GDM women. Nevertheless the increasing numbers of individuals with GDM and uncontrolled adiposity indices, require prompt attention be paid to the issue.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0348-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Behboudi-Gandevani&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Trend+of+various+adiposity+indices+in+women+with+and+without+history+of+gestational+diabetes%3A+a+population-based+cohort+study.&volume=19&issue=1&spage=24&epage=&date=2019&doi=10.1186%2Fs12902-019-0348-5&pmid=30782162&sid=OVID:medline
+
+<1769>
+Unique Identifier
+ 30770030
+Title
+ Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift. [Review]
+Source
+ Diabetes & Vascular Disease Research. 16(2):118-127, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nolan CJ; Prentki M
+Authors Full Name
+ Nolan, Christopher J; Prentki, Marc.
+Institution
+ Nolan, Christopher J. 1 Department of Endocrinology, The Canberra Hospital, Garran, ACT, Australia.
+ Nolan, Christopher J. 2 Australian National University Medical School and John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
+ Prentki, Marc. 3 CRCHUM and Montreal Diabetes Research Center, University of Montreal, Montreal, QC, Canada.
+ Prentki, Marc. 4 Department of Nutrition and Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC, Canada.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/pp [Physiopathology]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Diabetes Mellitus, Type 2/th [Therapy]
+ Female
+ Health Status
+ Humans
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ *Insulin-Secreting Cells/me [Metabolism]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Metabolic Syndrome/th [Therapy]
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/pp [Physiopathology]
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/ep [Epidemiology]
+ Polycystic Ovary Syndrome/pp [Physiopathology]
+ Prognosis
+ Risk Factors
+ Secretory Pathway
+Keyword Heading
+ Cardiovascular diseases
+ insulin hypersecretion
+ insulin resistance
+ insulin-mediated metabolic stress
+ metabolic syndrome
+ non-alcoholic fatty liver disease
+ polycystic ovary syndrome
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a unifying mechanism to explain the metabolic syndrome. Insulin resistance has most commonly been proposed for this role and is generally considered to be a root causative factor for not only metabolic syndrome but also for its associated conditions of non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), obesity-related type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD). An alternative view, for which evidence is mounting, is that hyper-responsiveness of islet beta-cells to a hostile environment, such as westernised lifestyle, is primary and that the resulting hyperinsulinaemia drives the other components of the metabolic syndrome. Importantly, within this new conceptual framework, insulin resistance, while always a biomarker and state of poor metabolic health, is not considered to be harmful, but a protective adaptive response of critical tissues including the myocardium against insulin-induced metabolic stress. This major shift in how metabolic syndrome can be considered puts insulin hypersecretion into position as the unifying mechanism. If shown to be correct, this new conceptual framework has major implications for the future prevention and management of the metabolic syndrome, including its associated conditions of NAFLD, PCOS, obesity-related T2D and ASCVD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1177%2f1479164119827611
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nolan&issn=1479-1641&title=Diabetes+%26+Vascular+Disease+Research&atitle=Insulin+resistance+and+insulin+hypersecretion+in+the+metabolic+syndrome+and+type+2+diabetes%3A+Time+for+a+conceptual+framework+shift.&volume=16&issue=2&spage=118&epage=127&date=2019&doi=10.1177%2F1479164119827611&pmid=30770030&sid=OVID:medline
+
+<1770>
+Unique Identifier
+ 30769284
+Title
+ Electrophilic nitro-oleic acid reverses obesity-induced hepatic steatosis.
+Source
+ Redox Biology. 22:101132, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khoo NKH; Fazzari M; Chartoumpekis DV; Li L; Guimaraes DA; Arteel GE; Shiva S; Freeman BA
+Authors Full Name
+ Khoo, Nicholas K H; Fazzari, Marco; Chartoumpekis, Dionysios V; Li, Lihua; Guimaraes, Danielle Aparecida; Arteel, Gavin E; Shiva, Sruti; Freeman, Bruce A.
+Institution
+ Khoo, Nicholas K H. Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address: nkhoo@pitt.edu.
+ Fazzari, Marco. Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States; Fondazione Ri.MED, Via Bandiera 11, 90133 Palermo, Italy.
+ Chartoumpekis, Dionysios V. Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
+ Li, Lihua. Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
+ Guimaraes, Danielle Aparecida. Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, United States.
+ Arteel, Gavin E. Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA 15261, United States.
+ Shiva, Sruti. Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, United States.
+ Freeman, Bruce A. Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address: freerad@pitt.edu.
+MeSH Subject Headings
+ Adipose Tissue/de [Drug Effects]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Blood Glucose
+ Body Weight/de [Drug Effects]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Glucose Intolerance
+ Hepatocytes/de [Drug Effects]
+ Hepatocytes/me [Metabolism]
+ Lipid Metabolism
+ Male
+ Mice
+ Mitochondria, Liver/de [Drug Effects]
+ Mitochondria, Liver/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/dt [Drug Therapy]
+ *Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Oleic Acids/ch [Chemistry]
+ *Oleic Acids/pd [Pharmacology]
+ Protective Agents/ch [Chemistry]
+ *Protective Agents/pd [Pharmacology]
+ Rosiglitazone/pd [Pharmacology]
+ Triglycerides/me [Metabolism]
+Abstract
+ Non-alcoholic fatty liver disease (NAFLD) is linked to obesity and insulin resistance and is the most prevalent chronic liver disease. During the development of obesity and NAFLD, mitochondria adapt to the increased lipid load in hepatocytes by increasing the rate of fatty acid oxidation. In concert with this, reactive species (RS) generation is increased, damaging hepatocytes and inducing inflammation. Hepatic mitochondrial dysfunction is central to the pathogenesis of NAFLD via undefined mechanisms. There are no FDA approved treatments for NAFLD other than weight loss and management of glucose tolerance. Electrophilic nitro-oleic acid (NO2-OA) displays anti-inflammatory and antioxidant signaling actions, thus mitochondrial dysfunction, RS production and inflammatory responses to NO2-OA and the insulin sensitizer rosiglitazone were evaluated in a murine model of insulin resistance and NAFLD. Mice on HFD for 20 wk displayed increased adiposity, insulin resistance and hepatic lipid accumulation (steatosis) compared to mice on normal chow (NC). The HFD mice had mitochondrial dysfunction characterized by lower hepatic mitochondrial complex I, IV and V activity compared to mice on NC. Treatment with NO2-OA or rosiglitazone for the last 42 days (out of 20 wk) abrogated HFD-mediated decreases in hepatic mitochondrial complex I, IV and V activity. Notably, NO2-OA treatment normalized hepatic triglyceride levels and significantly reversed hepatic steatosis. Despite the improved glucose tolerance observed upon rosiglitazone treatment, liver weight and hepatic triglycerides were significantly increased over vehicle-treated HFD mice. These observations support that the pleiotropic signaling actions of electrophilic fatty acids limit the complex hepatic and systemic pathogenic responses instigated by obesity, without the adverse effects of thiazolidinedione drugs such as rosiglitazone. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Oleic Acids). 0 (Protective Agents). 0 (Triglycerides). 05V02F2KDG (Rosiglitazone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.redox.2019.101132
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khoo&issn=2213-2317&title=Redox+Biology&atitle=Electrophilic+nitro-oleic+acid+reverses+obesity-induced+hepatic+steatosis.&volume=22&issue=&spage=101132&epage=&date=2019&doi=10.1016%2Fj.redox.2019.101132&pmid=30769284&sid=OVID:medline
+
+<1771>
+Unique Identifier
+ 30767409
+Title
+ Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial.
+Source
+ Obesity. 27(4):542-550, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xiao D; Zhu L; Edirisinghe I; Fareed J; Brailovsky Y; Burton-Freeman B
+Author NameID
+ Xiao, Di; ORCID: https://orcid.org/0000-0002-5916-6107
+Authors Full Name
+ Xiao, Di; Zhu, Lanjun; Edirisinghe, Indika; Fareed, Jawed; Brailovsky, Yevgeniy; Burton-Freeman, Britt.
+Institution
+ Xiao, Di. Center for Nutrition Research, Institution for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
+ Zhu, Lanjun. Center for Nutrition Research, Institution for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
+ Edirisinghe, Indika. Center for Nutrition Research, Institution for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
+ Fareed, Jawed. Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois, USA.
+ Brailovsky, Yevgeniy. Department of Medicine, Loyola University Medical Center, Maywood, Illinois, USA.
+ Burton-Freeman, Britt. Center for Nutrition Research, Institution for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.
+ Burton-Freeman, Britt. Department of Nutrition, University of California, Davis, California, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Breakfast
+ Cross-Over Studies
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ Female
+ *Fruit
+ Health Status Indicators
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ Obesity/me [Metabolism]
+ Overweight/bl [Blood]
+ Overweight/dh [Diet Therapy]
+ Overweight/me [Metabolism]
+ Postprandial Period/ph [Physiology]
+ *Prediabetic State/dh [Diet Therapy]
+ *Prediabetic State/me [Metabolism]
+ Risk Factors
+ Rubus/ph [Physiology]
+ *Rubus
+ Triglycerides/bl [Blood]
+Abstract
+ OBJECTIVE: This study investigated the effect of red raspberry intake on meal-induced postprandial metabolic responses in individuals who have overweight or obesity with prediabetes and insulin resistance (PreDM-IR), and in metabolically healthy individuals (Reference).
+
+ METHODS: Thirty-two adults (PreDM-IR, n = 21; Reference, n = 11) were randomized to a controlled, three-arm, single-blinded, crossover trial. Participants were provided 0 g of frozen red raspberries (Control), 125 g of frozen red raspberries (RR-125) (~1 cup), or 250 g of frozen red raspberries (RR-250) (~2 cups), with a challenge breakfast meal (high carbohydrate/moderate fat) on three separate days. Multiple blood samples were collected up to 8 hours post breakfast with a final blood sample at 24 hours. A snack was provided at 6 hours.
+
+ RESULTS: Breakfast containing RR-125 and RR-250 significantly reduced 2-hour insulin area under the curve, and RR-250 reduced peak insulin, peak glucose, and 2-hour glucose AUC compared with Control in the PreDM-IR group (P < 0.05). Postprandial triglycerides were significantly lower after RR-125 versus RR-250 (P = 0.01) but not different from Control (P > 0.05). No significant meal-related differences were observed for oxidative stress or inflammatory biomarkers.
+
+ CONCLUSIONS: Our findings suggest that red raspberries aid in postmeal glycemic control in individuals with PreDM-IR, reducing glycemic burden with less insulin, which may be related to improved tissue insulin sensitivity. Copyright © 2019 The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Triglycerides).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2foby.22406
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xiao&issn=1930-7381&title=Obesity&atitle=Attenuation+of+Postmeal+Metabolic+Indices+with+Red+Raspberries+in+Individuals+at+Risk+for+Diabetes%3A+A+Randomized+Controlled+Trial.&volume=27&issue=4&spage=542&epage=550&date=2019&doi=10.1002%2Foby.22406&pmid=30767409&sid=OVID:medline
+
+<1772>
+Unique Identifier
+ 30759960
+Title
+ Associations Between Serum Uric Acid Concentrations and Cardiometabolic Risk and Renal Injury in Obese and Overweight Children.
+Source
+ Journal of clinical research in pediatric endocrinology. 11(3):262-269, 2019 09 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ozalp Kizilay D; Sen S; Ersoy B
+Author NameID
+ Ozalp Kizilay, Deniz; ORCID: https://orcid.org/0000-0003-4529-4404
+ Sen, Semra; ORCID: https://orcid.org/0000-0002-9920-0269
+ Ersoy, Betul; ORCID: https://orcid.org/0000-0003-1696-8406
+Authors Full Name
+ Ozalp Kizilay, Deniz; Sen, Semra; Ersoy, Betul.
+Institution
+ Ozalp Kizilay, Deniz. Cigli State Training Hospital, Clinic of Pediatrics, Division of Pediatric Endocrinology, Izmir, Turkey
+ Sen, Semra. Manisa Celal Bayar University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Disease, Manisa, Turkey
+ Ersoy, Betul. Manisa Celal Bayar University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Manisa, Turkey
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ Child
+ Female
+ Follow-Up Studies
+ Humans
+ *Hyperuricemia/bl [Blood]
+ Hyperuricemia/di [Diagnosis]
+ Hyperuricemia/et [Etiology]
+ *Kidney Diseases/bl [Blood]
+ Kidney Diseases/di [Diagnosis]
+ Kidney Diseases/et [Etiology]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prognosis
+ Retrospective Studies
+ *Uric Acid/bl [Blood]
+Keyword Heading
+ obesity
+ renal injury
+ cardiovascular risk
+ child
+ Serum uric acid concentration
+ metabolic syndrome
+ insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: The aim of this study was to assess the association between serum uric acid concentration (SUAC) and the parameters of the metabolic syndrome (MetS) and insulin resistance (IR). The secondary aim was to evaluate whether hyperuricemia is associated with renal injury and cardiovascular risk in obese (OB) and overweight (OW) children.
+
+ Methods: The subjects of this study consisted of OB/OW children and adolescents (ages: 8-18 years). Sex and age specific serum uric acid (SUA) olarak degistirilecek percentiles were used and a SUA >75th percentile was accepted as hyperuricemia. Anthropometric data, blood pressure (BP) measurements and biochemical parameters, including fasting blood glucose, insulin, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol, triglycerides (TG), aspartate aminotransferase, alanine aminotransferase, homeostatic model assessments of IR (HOMA-IR) and SUAC were recorded. Oral glucose tolerance tests (OGTT) were performed in all patients. MetS was defined according to the International Diabetes Federation criteria. Total cholesterol/HDL-c ratio >4 and TG/HDL-c ratio >2.2 were used as the atherogenic index (AI) indicating cardiovascular risk. Urinary albumin excretion in a 24-hour and also in a first-morning urine sample were measured. Renal injury was assessed by microalbuminuria according to the National Kidney Foundation criteria.
+
+ Results: There were 128 participants; 52 (40%) had elevated (SUA >75th percentile) and 76 had (60%) normal SUAC. The mean+/-SD age was 13.1+/-2.6 years and 87 (67.4%) were female. The mean+/-SD weight was 73+/-18.97 kg and mean+/-SD height was 155.4+/-12.11 cm. There was no statistical difference between the groups with and without hyperuricemia in terms of age, sex, puberty stage and degree of obesity. Increased SUAC were significantly associated with higher waist-to-hip ratio (WHR), fasting insulin levels and insulin at 30 and 60 minutes during OGTT, HOMA-IR, lower HDL-c and presence of hypertriglyceridemia as well as with decreased HDL-c, increased AI, presence of IR and MetS. BP and microalbuminuria were not associated with SUAC. SUAC showed significant positive correlations with waist circumference, WHR, post-challenge glucose level at 60 minutes, with fasting insulin, post-challenge insulin levels at 30, 60, 90 and 120 minutes and also with HOMA-IR, total cholesterol/HDL-c ratio, TG/HDL-c ratio and a number of other criteria related to MetS. Also, an inverse correlation with HDL-c was noted.
+
+ Conclusion: In OB/OW children frequency of MetS, IR and dislipidemia increases with increased SUAC, a finding independent of age, puberty, gender and body mass index. Patients meeting all of the MetS criteria had the highest SUAC. These results demonstrate that the association between UA and metabolic and cardiovascular risk factors can be detected early in childhood. Thus, we recommend monitoring SUAC in OB children and we believe that prevention of SUAC elevation in early life has a potential protective effect on metabolic impairment and subsequent comorbidities.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.4274%2fjcrpe.galenos.2018.2019.0241
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ozalp+Kizilay&issn=1308-5735&title=Journal+of+clinical+research+in+pediatric+endocrinology&atitle=Associations+Between+Serum+Uric+Acid+Concentrations+and+Cardiometabolic+Risk+and+Renal+Injury+in+Obese+and+Overweight+Children.&volume=11&issue=3&spage=262&epage=269&date=2019&doi=10.4274%2Fjcrpe.galenos.2018.2019.0241&pmid=30759960&sid=OVID:medline
+
+<1773>
+Unique Identifier
+ 30758976
+Title
+ A free-choice high-fat, high-sucrose diet induces hyperphagia, obesity, and cardiovascular dysfunction in female cycling and pregnant rats.
+Source
+ American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 316(5):R472-R485, 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ahmed H; Hannan JL; Apolzan JW; Osikoya O; Cushen SC; Romero SA; Goulopoulou S
+Author NameID
+ Hannan, Johanna L; ORCID: https://orcid.org/0000-0002-8469-8105
+ Goulopoulou, Styliani; ORCID: https://orcid.org/0000-0001-7636-8256
+Authors Full Name
+ Ahmed, Hijab; Hannan, Johanna L; Apolzan, John W; Osikoya, Oluwatobiloba; Cushen, Spencer C; Romero, Steven A; Goulopoulou, Styliani.
+Institution
+ Ahmed, Hijab. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
+ Hannan, Johanna L. Department of Physiology, Brody School of Medicine, Greenville, North Carolina.
+ Apolzan, John W. Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana.
+ Osikoya, Oluwatobiloba. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
+ Cushen, Spencer C. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
+ Romero, Steven A. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
+ Goulopoulou, Styliani. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
+MeSH Subject Headings
+ Adiposity
+ Animal Nutritional Physiological Phenomena
+ Animals
+ Behavior, Animal
+ Biomarkers/bl [Blood]
+ Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pp [Physiopathology]
+ Choice Behavior
+ *Diet, High-Fat/ae [Adverse Effects]
+ Dietary Sucrose/me [Metabolism]
+ *Dietary Sucrose/to [Toxicity]
+ *Energy Metabolism
+ *Estrous Cycle
+ Feeding Behavior
+ Female
+ Fetal Growth Retardation/bl [Blood]
+ *Fetal Growth Retardation/et [Etiology]
+ Fetal Growth Retardation/pp [Physiopathology]
+ Hemodynamics
+ Hyperphagia/bl [Blood]
+ *Hyperphagia/et [Etiology]
+ Hyperphagia/pp [Physiopathology]
+ Hyperphagia/px [Psychology]
+ Maternal Nutritional Physiological Phenomena
+ Nutritional Status
+ Obesity/bl [Blood]
+ *Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ Pregnancy
+ Rats, Sprague-Dawley
+ Weight Gain
+Keyword Heading
+ diet-induced obesity
+ energy intake
+ female
+ uterine artery
+ vascular function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The main objective of these studies was to characterize metabolic, body composition, and cardiovascular responses to a free-choice high-fat, high-sucrose diet in female cycling and pregnant rats. In the nonpregnant state, female Sprague-Dawley rats offered a 3-wk free-choice high-fat, high-sucrose diet had greater energy intake, adiposity, serum leptin, and triglyceride concentrations compared with rats fed with standard chow and developed glucose intolerance. In addition, choice-diet-fed rats had larger cardiac ventricular weights, smaller kidney and pancreas weights, and higher blood pressure than chow-fed rats, but they did not exhibit resistance artery endothelial dysfunction. When the free-choice diet continued throughout pregnancy, rats remained hyperphagic, hyperleptinemic, and obese. Choice pregnant rats exhibited uterine artery endothelial dysfunction and had smaller fetuses compared with chow pregnant rats. Pregnancy normalized mean arterial blood pressure and pancreas weights in choice rats. These studies are the first to provide a comprehensive evaluation of free-choice high-fat, high-sucrose diet on metabolic and cardiovascular functions in female rats, extending the previous studies in males to female cycling and pregnant rodents. Free-choice diet may provide a new model of preconceptual maternal obesity to study the role of increased energy intake, individual food components, and preexisting maternal obesity on maternal and offspring physiological responses during pregnancy and after birth.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Sucrose).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1152%2fajpregu.00391.2018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ahmed&issn=0363-6119&title=American+Journal+of+Physiology+-+Regulatory+Integrative+%26+Comparative+Physiology&atitle=A+free-choice+high-fat%2C+high-sucrose+diet+induces+hyperphagia%2C+obesity%2C+and+cardiovascular+dysfunction+in+female+cycling+and+pregnant+rats.&volume=316&issue=5&spage=R472&epage=R485&date=2019&doi=10.1152%2Fajpregu.00391.2018&pmid=30758976&sid=OVID:medline
+
+<1774>
+Unique Identifier
+ 30756513
+Title
+ Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study.
+Source
+ Journal of Diabetes Investigation. 10(5):1209-1214, 2019 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hu H; Nakagawa T; Honda T; Yamamoto S; Okazaki H; Yamamoto M; Miyamoto T; Eguchi M; Kochi T; Shimizu M; Murakami T; Tomita K; Ogasawara T; Sasaki N; Uehara A; Kuwahara K; Kabe I; Mizoue T; Sone T; Dohi S
+Author NameID
+ Hu, Huanhuan; ORCID: http://orcid.org/0000-0001-8558-2895
+Corporate Author
+ Japan Epidemiology Collaboration on Occupational Health Study Group
+Authors Full Name
+ Hu, Huanhuan; Nakagawa, Tohru; Honda, Toru; Yamamoto, Shuichiro; Okazaki, Hiroko; Yamamoto, Makoto; Miyamoto, Toshiaki; Eguchi, Masafumi; Kochi, Takeshi; Shimizu, Makiko; Murakami, Taizo; Tomita, Kentaro; Ogasawara, Takayuki; Sasaki, Naoko; Uehara, Akihiko; Kuwahara, Keisuke; Kabe, Isamu; Mizoue, Tetsuya; Sone, Tomofumi; Dohi, Seitaro.
+Institution
+ Hu, Huanhuan. Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan.
+ Nakagawa, Tohru. Hitachi, Ltd., Ibaraki, Japan.
+ Honda, Toru. Hitachi, Ltd., Ibaraki, Japan.
+ Yamamoto, Shuichiro. Hitachi, Ltd., Ibaraki, Japan.
+ Okazaki, Hiroko. Mitsui Chemicals, Inc., Tokyo, Japan.
+ Yamamoto, Makoto. Yamaha Corporation, Shizuoka, Japan.
+ Miyamoto, Toshiaki. Nippon Steel and Sumitomo Metal Corporation Kimitsu Works, Chiba, Japan.
+ Eguchi, Masafumi. Furukawa Electric Co., Ltd., Tokyo, Japan.
+ Kochi, Takeshi. Furukawa Electric Co., Ltd., Tokyo, Japan.
+ Shimizu, Makiko. Mizue Medical Clinic, Keihin Occupational Health Center, Kanagawa, Japan.
+ Murakami, Taizo. Mizue Medical Clinic, Keihin Occupational Health Center, Kanagawa, Japan.
+ Tomita, Kentaro. Mitsubishi Plastics, Inc., Tokyo, Japan.
+ Ogasawara, Takayuki. Mitsubishi Fuso Truck and Bus Corporation, Kanagawa, Japan.
+ Sasaki, Naoko. Mitsubishi Fuso Truck and Bus Corporation, Kanagawa, Japan.
+ Uehara, Akihiko. Seijinkai Shizunai Hospital, Hokkaido, Japan.
+ Kuwahara, Keisuke. Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan.
+ Kuwahara, Keisuke. Teikyo University Graduate School of Public Health, Tokyo, Japan.
+ Kabe, Isamu. Furukawa Electric Co., Ltd., Tokyo, Japan.
+ Mizoue, Tetsuya. Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan.
+ Sone, Tomofumi. National Institute of Public Health, Saitama, Japan.
+ Dohi, Seitaro. Mitsui Chemicals, Inc., Tokyo, Japan.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ *Body Mass Index
+ *Creatinine/bl [Blood]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ *Dyslipidemias/co [Complications]
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ *Hypertension/co [Complications]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ *Occupational Health/sn [Statistics & Numerical Data]
+ Prognosis
+ Prospective Studies
+ Risk Factors
+ Young Adult
+Keyword Heading
+ Diabetes
+ Serum creatinine
+ Skeletal muscle
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: We examined a prospective association between serum creatinine levels and diabetes.
+
+ MATERIALS AND METHODS: The present study included 31,343 male workers without diabetes, and aged between 20 and 64 years at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either glycated hemoglobin levels >=6.5%, random glucose levels >=200 mg/dL, fasting glucose levels >=126 mg/dL or receiving antidiabetic treatment. Cox proportional hazards regression analysis was carried out to estimate the hazard ratio (HR) and 95% confidence interval (CI).
+
+ RESULTS: With a median observation of 7.7 years, 2,509 participants developed diabetes. After adjusting for age, smoking, body mass index, hypertension and dyslipidemia, lower cumulative average serum creatinine levels were related to a greater diabetes risk: HRs were 1.56 (95% CI 1.35-1.82), 1.22 (1.09-1.35) and 1.06 (0.96-1.17) for the participants with serum creatinine <0.70, 0.70-0.79 and 0.80-0.89 mg/dL, respectively, compared with those with 0.90-1.20 mg/dL (P for trend <0.001). The serum creatinine-diabetes association was more pronounced among older adults (serum creatinine <0.70 vs 0.90-1.20 mg/dL, HR 1.66, 95% CI 1.37-2.00) than younger adults (HR 1.32, 95% CI 1.02-1.71; P for interaction by age group = 0.001).
+
+ CONCLUSIONS: Low serum creatinine is associated with an increased risk of diabetes. Screening serum creatinine levels can be used to identify those who are at high risk of diabetes. Copyright © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human). AYI8EX34EU (Creatinine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fjdi.13024
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hu&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Low+serum+creatinine+and+risk+of+diabetes%3A+The+Japan+Epidemiology+Collaboration+on+Occupational+Health+Study.&volume=10&issue=5&spage=1209&epage=1214&date=2019&doi=10.1111%2Fjdi.13024&pmid=30756513&sid=OVID:medline
+
+<1775>
+Unique Identifier
+ 30754039
+Title
+ Effects of a Hypocaloric, Nutritionally Complete, Higher Protein Meal Plan on Regional Body Fat and Cardiometabolic Biomarkers in Older Adults with Obesity.
+Source
+ Annals of Nutrition & Metabolism. 74(2):149-155, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Serra MC; Beavers DP; Henderson RM; Kelleher JL; Kiel JR; Beavers KM
+Authors Full Name
+ Serra, Monica C; Beavers, Daniel P; Henderson, Rebecca M; Kelleher, Jessica L; Kiel, Jessica R; Beavers, Kristen M.
+Institution
+ Serra, Monica C. Department of Medicine, Atlanta VA Medical Center, Emory University School of Medicine, Atlanta, Georgia, USA, mserra@emory.edu.
+ Beavers, Daniel P. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
+ Henderson, Rebecca M. Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
+ Kelleher, Jessica L. Department of Medicine, Atlanta VA Medical Center, Emory University School of Medicine, Atlanta, Georgia, USA.
+ Kiel, Jessica R. Medifast, Inc., Baltimore, Maryland, USA.
+ Beavers, Kristen M. Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.
+MeSH Subject Headings
+ Adipose Tissue
+ Aged
+ Biomarkers
+ Body Composition
+ *Cardiovascular Diseases/pc [Prevention & Control]
+ Diet, High-Protein
+ *Diet, Reducing
+ Female
+ Humans
+ Male
+ Meals
+ *Obesity/dh [Diet Therapy]
+ *Weight Loss
+Keyword Heading
+ Body composition
+ Obesity
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Whether improvements in cardiometabolic health following weight loss (WL) are associated with changes in regional body fat distribution (gluteal vs. -android) is not well documented.
+
+ METHODS: Older (age: 70 +/- 4 years; mean +/- SD) adults with obesity were randomized to a 6-month WL program (WL; n = 47), accomplished using a hypocaloric, nutritionally complete, higher protein -(targeting >=1.0 g/kg/day) meal plan, or a weight stability (WS; n = 49) program. Android, gynoid, visceral, and subcutaneous abdominal fat masses (via dual energy X-ray absorptiometry ) and fasting glucose and lipid profiles were assessed at baseline and 6 months.
+
+ RESULTS: The WL group lost more body weight (WL: -8.6% vs. WS: -1.7%, p < 0.01), resulting in a reduction in fat mass at each region only following WL (all p < 0.05). The decline in the ratio of android/gynoid fat mass also was significant only following WL, resulting in greater declines than WS (mean [95% CI]; WL: -0.026 [-0.040 to -0.011] vs. WS: 0.003 [-0.012 to 0.019] g, p < 0.01). The change in the ratio of visceral/subcutaneous abdominal fat mass was not significant in either group and did not differ between groups (WL: 0.65 [-0.38 to 1.68] vs. WS: 0.05 [-1.00 to 1.10] g, p = 0.42). In general, the improvements in glucose and lipid profiles were associated with declines in fat mass at the gynoid and android regions (r's = 0.20-0.42, all p < 0.05), particularly the visceral depot but not the ratios.
+
+ CONCLUSION: WL achieved via a hypocaloric, nutritionally complete, higher protein meal plan is effective in reducing body fat in the android, gynoid, and visceral depots, which relate to cardiometabolic improvements. Copyright © 2019 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1159%2f000497066
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Serra&issn=0250-6807&title=Annals+of+Nutrition+%26+Metabolism&atitle=Effects+of+a+Hypocaloric%2C+Nutritionally+Complete%2C+Higher+Protein+Meal+Plan+on+Regional+Body+Fat+and+Cardiometabolic+Biomarkers+in+Older+Adults+with+Obesity.&volume=74&issue=2&spage=149&epage=155&date=2019&doi=10.1159%2F000497066&pmid=30754039&sid=OVID:medline
+
+<1776>
+Unique Identifier
+ 30740673
+Title
+ Neutrophil-to-lymphocyte ratio and its relation with pro-inflammatory mediators, visceral adiposity and carotid intima-media thickness in population with obesity.
+Source
+ European Journal of Clinical Investigation. 49(5):e13085, 2019 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Suarez-Cuenca JA; Ruiz-Hernandez AS; Mendoza-Castaneda AA; Dominguez-Perez GA; Hernandez-Patricio A; Vera-Gomez E; De la Pena-Sosa G; Banderas-Lares DZ; Montoya-Ramirez J; Blas-Azotla R; Ortiz-Fernandez M; Salamanca-Garcia M; Melchor-Lopez A; Mondragon-Teran P; Contreras-Ramos A; Alcaraz-Estrada SL
+Author NameID
+ Suarez-Cuenca, Juan Antonio; ORCID: https://orcid.org/0000-0002-2098-5658
+Authors Full Name
+ Suarez-Cuenca, Juan Antonio; Ruiz-Hernandez, Atzin S; Mendoza-Castaneda, Ana A; Dominguez-Perez, Gabriela A; Hernandez-Patricio, Alejandro; Vera-Gomez, Eduardo; De la Pena-Sosa, Gustavo; Banderas-Lares, Diana Z; Montoya-Ramirez, Jesus; Blas-Azotla, Ricardo; Ortiz-Fernandez, Moises; Salamanca-Garcia, Moises; Melchor-Lopez, Alberto; Mondragon-Teran, Paul; Contreras-Ramos, Alejandra; Alcaraz-Estrada, Sofia L.
+Institution
+ Suarez-Cuenca, Juan Antonio. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Suarez-Cuenca, Juan Antonio. Internal Medicine Department, Hospital General de Xoco, SEDESA, Mexico City, Mexico.
+ Suarez-Cuenca, Juan Antonio. Internal Medicine Department, Hospital General de Zona No. 58, IMSS, State of Mexico, Mexico.
+ Ruiz-Hernandez, Atzin S. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Mendoza-Castaneda, Ana A. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Dominguez-Perez, Gabriela A. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Hernandez-Patricio, Alejandro. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Vera-Gomez, Eduardo. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ De la Pena-Sosa, Gustavo. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Banderas-Lares, Diana Z. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Montoya-Ramirez, Jesus. Bariatric Surgery Department, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Blas-Azotla, Ricardo. Bariatric Surgery Department, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Ortiz-Fernandez, Moises. Bariatric Surgery Department, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Salamanca-Garcia, Moises. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Melchor-Lopez, Alberto. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Melchor-Lopez, Alberto. Internal Medicine Department, Hospital General de Xoco, SEDESA, Mexico City, Mexico.
+ Melchor-Lopez, Alberto. Internal Medicine Department, Hospital General de Zona No. 58, IMSS, State of Mexico, Mexico.
+ Mondragon-Teran, Paul. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+ Contreras-Ramos, Alejandra. Laboratorio de Biologia del Desarrollo y Teratogenesis Experimental, Hospital Infantil de Mexico "Federico Gomez", Mexico City, Mexico.
+ Alcaraz-Estrada, Sofia L. Division of Biomedical Research, Department of Experimental Metabolism and Clinical Research, Centro Medico Nacional "20 de Noviembre", Mexico City, Mexico.
+MeSH Subject Headings
+ *Adipokines/me [Metabolism]
+ Adiposity/ph [Physiology]
+ Adult
+ Atherosclerosis/bl [Blood]
+ *Atherosclerosis/et [Etiology]
+ Atherosclerosis/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ Carotid Intima-Media Thickness
+ *Cytokines/me [Metabolism]
+ Disease Progression
+ Female
+ Humans
+ Intra-Abdominal Fat/dg [Diagnostic Imaging]
+ Lymphocytes/ph [Physiology]
+ Male
+ Middle Aged
+ Neutrophils/ph [Physiology]
+ Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ Prospective Studies
+Keyword Heading
+ IL-1beta
+ TNF-alpha
+ carotid intima-media thickness
+ neutrophil-to-lymphocyte ratio
+ obesity
+ subclinical atherogenesis
+ visceral adiposity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Atherosclerosis represents a cardiovascular risk. Chronic inflammation is a key factor for atherogenic progression. Neutrophil-to-lymphocyte ratio (NLR) has been proposed as a novel biomarker for cardiovascular risks. We aimed to explore whether NLR was related to surrogate pro-atherogenic promoters driving atherogenic progression, as measured by carotid intima-media thickness (CIMT).
+
+ STUDY DESIGN: Thirty-one patients with obesity candidates for bariatric surgery were recruited from Centro Medico Nacional "20 de Noviembre", ISSSTE, Mexico City. The results are part of the "CROP" study (NCT03561987). NLR was calculated from routine complete blood count, and its relation with plasma pro-inflammatory mediators (hsCRP, TNF-alpha and IL-1beta), adipokines (adiponectin and leptin), adiposity markers (visceral adipose tissue [VAT] determined from CT scan image and VAT individual adipocyte area at histological sample) and CIMT were determined.
+
+ RESULTS: Neutrophil-to-lymphocyte ratio correlated with hsCRP (Spearman's r = 0.70 [95% CI 0.46 to 0.85], P < 0.01), TNF-alpha (r = 0.69 [0.44 to 0.84], P < 0.0001) and adiponectin (r = -0.69 [-0.84 to -0.45], P < 0.03), as well as with VAT individual adipocyte area (r = 0.64 [0.37 to 0.81], P < 0.0001) and with VAT area (r = 0.43; [0.07 to 0.68], P < 0.01). Leptin and adiponectin showed further independent association with higher NLR (multivariate regression analysis OR 7.9 [95% CI 1.1 to 56.2] P = 0.03 and 0.1 [0.01 to 1.0] P = 0.05, respectively). Moreover, NLR distribution significantly varied between subgroups divided according to progressive CIMT (P = 0.05); whereas adiponectin and VAT adipocyte area associated with CIMT > 0.9 mm (univariate analysis OR 0.1 [0.01 to 1.0] P = 0.05 and 13.1 [1.4 to 126.3] P = 0.03, respectively).
+
+ CONCLUSION: Neutrophil-to-lymphocyte ratio was related to pro-inflammatory, adiposity biomarkers and progressive subclinical atherogenesis. Copyright © 2019 Stichting European Society for Clinical Investigation Journal Foundation.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2feci.13085
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Suarez-Cuenca&issn=0014-2972&title=European+Journal+of+Clinical+Investigation&atitle=Neutrophil-to-lymphocyte+ratio+and+its+relation+with+pro-inflammatory+mediators%2C+visceral+adiposity+and+carotid+intima-media+thickness+in+population+with+obesity.&volume=49&issue=5&spage=e13085&epage=&date=2019&doi=10.1111%2Feci.13085&pmid=30740673&sid=OVID:medline
+
+<1777>
+Unique Identifier
+ 30738641
+Title
+ Platelet number is positively and independently associated with glycated hemoglobin in non-diabetic overweight and obese subjects.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 29(3):254-259, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ De Pergola G; Giagulli VA; Guastamacchia E; Bartolomeo N; Tatoli R; Lampignano L; Silvestris F; Triggiani V
+Authors Full Name
+ De Pergola, G; Giagulli, V A; Guastamacchia, E; Bartolomeo, N; Tatoli, R; Lampignano, L; Silvestris, F; Triggiani, V.
+Institution
+ De Pergola, G. Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy. Electronic address: g.depergola@libero.it.
+ Giagulli, V A. Outpatient Clinic for Endocrinology and Metabolic Diseases, PTA "F.Jaia" Conversano, ASL, Bari, Italy; Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari, School of Medicine, Policlinico, Piazza GiulioCesare, 70124, Bari, Italy.
+ Guastamacchia, E. Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari, School of Medicine, Policlinico, Piazza GiulioCesare, 70124, Bari, Italy.
+ Bartolomeo, N. Medical Statistics, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza GiulioCesare, 70124, Bari, Italy.
+ Tatoli, R. Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
+ Lampignano, L. Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
+ Silvestris, F. Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
+ Triggiani, V. Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari, School of Medicine, Policlinico, Piazza GiulioCesare, 70124, Bari, Italy.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ *Blood Platelets/me [Metabolism]
+ Female
+ *Glucose Metabolism Disorders/bl [Blood]
+ Glucose Metabolism Disorders/di [Diagnosis]
+ *Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Overweight/bl [Blood]
+ Overweight/di [Diagnosis]
+ Platelet Count
+ Young Adult
+Keyword Heading
+ Glycated hemoglobin
+ Obesity
+ Overweight
+ Platelet
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: A significant increase in platelet count may be a risk factor for atherosclerotic cardiovascular disease. This study investigates the association between platelet number and glucose metabolism, evaluated by glycated hemoglobin (HbA1c) levels, in a apparently healthy population represented by overweight and obese subjects with normal glucose and HbA1c levels.
+
+ METHODS AND RESULTS: As many as 240 subjects, 177 women and 63 men, aged 18-70 years, were enrolled. Body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure levels, platelet count and fasting blood glucose, insulin, insulin resistance, HbA1c, uric acid, triglyceride, total cholesterol, high and low density lipoprotein cholesterol concentrations were evaluated. Concerning the univariate correlation analyses between platelets number and all other variables, platelet count was significantly (and positively) correlated only with HbA1c (P < 0.05) and female sex (P < 0.01). HbA1c (P < 0.05), female sex (P < 0.001), and diastolic blood pressure (P < 0.01), positively, and age (P < 0.05) and systolic blood pressure (P < 0.05), negatively, were significantly and independently associated to platelet count in a final multiple regression analysis.
+
+ CONCLUSION: This is the first study showing a strong positive and independent relationship between HbA1c and platelet number in non-diabetic overweight and obese subjects. Copyright © 2018. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.numecd.2018.12.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=De+Pergola&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Platelet+number+is+positively+and+independently+associated+with+glycated+hemoglobin+in+non-diabetic+overweight+and+obese+subjects.&volume=29&issue=3&spage=254&epage=259&date=2019&doi=10.1016%2Fj.numecd.2018.12.007&pmid=30738641&sid=OVID:medline
+
+<1778>
+Unique Identifier
+ 30733965
+Title
+ The Influence of FTO Polymorphism rs9939609 on Obesity, Some Clinical Features, and Disturbance of Carbohydrate Metabolism in Patients with Psoriasis.
+Source
+ BioMed Research International. 2019:7304345, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tupikowska-Marzec M; Kolackov K; Zdrojowy-Welna A; Sloka NK; Szepietowski JC; Maj J
+Author NameID
+ Kolackov, Katarzyna; ORCID: https://orcid.org/0000-0003-4570-0054
+ Szepietowski, Jacek C; ORCID: https://orcid.org/0000-0003-0766-6342
+Authors Full Name
+ Tupikowska-Marzec, Malgorzata; Kolackov, Katarzyna; Zdrojowy-Welna, Aleksandra; Sloka, Natalia K; Szepietowski, Jacek C; Maj, J.
+Institution
+ Tupikowska-Marzec, Malgorzata. Department and Clinic of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland.
+ Kolackov, Katarzyna. Department and Clinic of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland.
+ Zdrojowy-Welna, Aleksandra. Department and Clinic of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland.
+ Sloka, Natalia K. Department and Clinic of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland.
+ Szepietowski, Jacek C. Department and Clinic of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland.
+ Maj, J. Department and Clinic of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland.
+MeSH Subject Headings
+ Adult
+ Aged
+ Alleles
+ *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/ge [Genetics]
+ Biomarkers/me [Metabolism]
+ *Carbohydrate Metabolism/ge [Genetics]
+ Female
+ Gene Frequency
+ *Genetic Predisposition to Disease
+ Humans
+ Inflammation/ge [Genetics]
+ Inflammation/pa [Pathology]
+ Male
+ Middle Aged
+ *Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ *Polymorphism, Single Nucleotide/ge [Genetics]
+ *Psoriasis/ge [Genetics]
+ *Psoriasis/me [Metabolism]
+Abstract
+ BACKGROUND: Psoriasis is often accompanied by obesity, hyperlipidemia, diabetes, and metabolic syndrome as risk factors of cardiovascular conditions and premature mortality.
+
+ OBJECTIVE: The study was aimed at investigating whether psoriatic patients, who carry risk allele of obesity-related FTO gene, are more predisposed to obesity and metabolic disturbances and whether it influences the severity of psoriasis.
+
+ METHODS: 197 patients with psoriasis, representing Lower Silesia region of Poland, underwent physical examination and anthropometric measurements. Blood samples for biochemical and genetic analysis were collected. All patients were genotyped for FTO gene rs9939609 variant. Identification of SNP was conducted with the use of minisequencing method.
+
+ RESULTS: Around 63% of patients were carriers of at least one risk allele A and 20% were AA homozygotes. The A allele was associated with increased BMI and hip and waist circumferences. The carriers of risk allele had increased PASI and CRP values and tended to have an increased insulin concentration.
+
+ CONCLUSION: Psoriatic patients, carriers of risk allele of FTO gene rs9939609, have an increased risk for more severe psoriasis and obesity and may develop obesity-induced insulin resistance.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 1-14-11-33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO). EC 1-14-11-33 (FTO protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f7304345
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tupikowska-Marzec&issn=2314-6141&title=BioMed+Research+International&atitle=The+Influence+of+FTO+Polymorphism+rs9939609+on+Obesity%2C+Some+Clinical+Features%2C+and+Disturbance+of+Carbohydrate+Metabolism+in+Patients+with+Psoriasis.&volume=2019&issue=&spage=7304345&epage=&date=2019&doi=10.1155%2F2019%2F7304345&pmid=30733965&sid=OVID:medline
+
+<1779>
+Unique Identifier
+ 30732594
+Title
+ SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob-/- mice.
+Source
+ Cardiovascular Diabetology. 18(1):16, 2019 02 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adingupu DD; Gopel SO; Gronros J; Behrendt M; Sotak M; Miliotis T; Dahlqvist U; Gan LM; Jonsson-Rylander AC
+Author NameID
+ Adingupu, Damilola D; ORCID: https://orcid.org/0000-0002-0312-2359
+Authors Full Name
+ Adingupu, Damilola D; Gopel, Sven O; Gronros, Julia; Behrendt, Margareta; Sotak, Matus; Miliotis, Tasso; Dahlqvist, Ulrika; Gan, Li-Ming; Jonsson-Rylander, Ann-Cathrine.
+Institution
+ Adingupu, Damilola D. Bioscience, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, Molndal, 431 83, Gothenburg, Sweden.
+ Gopel, Sven O. Bioscience, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, Molndal, 431 83, Gothenburg, Sweden. Sven.Gopel@astrazeneca.com.
+ Gronros, Julia. Bioscience, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, Molndal, 431 83, Gothenburg, Sweden.
+ Behrendt, Margareta. Bioscience, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, Molndal, 431 83, Gothenburg, Sweden.
+ Sotak, Matus. Bioscience, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, Molndal, 431 83, Gothenburg, Sweden.
+ Miliotis, Tasso. Translational Science, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Gothenburg, Sweden.
+ Dahlqvist, Ulrika. Bioscience, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, Molndal, 431 83, Gothenburg, Sweden.
+ Gan, Li-Ming. Early Clinical Development, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Gothenburg, Sweden.
+ Gan, Li-Ming. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
+ Gan, Li-Ming. Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
+ Jonsson-Rylander, Ann-Cathrine. Bioscience, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, Molndal, 431 83, Gothenburg, Sweden.
+MeSH Subject Headings
+ Animals
+ *Benzhydryl Compounds/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ Coronary Artery Disease/et [Etiology]
+ Coronary Artery Disease/me [Metabolism]
+ Coronary Artery Disease/pp [Physiopathology]
+ *Coronary Artery Disease/pc [Prevention & Control]
+ *Coronary Circulation/de [Drug Effects]
+ Diabetic Angiopathies/et [Etiology]
+ Diabetic Angiopathies/me [Metabolism]
+ Diabetic Angiopathies/pp [Physiopathology]
+ *Diabetic Angiopathies/pc [Prevention & Control]
+ Diabetic Cardiomyopathies/et [Etiology]
+ Diabetic Cardiomyopathies/me [Metabolism]
+ Diabetic Cardiomyopathies/pp [Physiopathology]
+ *Diabetic Cardiomyopathies/pc [Prevention & Control]
+ Disease Models, Animal
+ Energy Metabolism/de [Drug Effects]
+ *Glucosides/pd [Pharmacology]
+ Male
+ Mice, Inbred C57BL
+ *Microcirculation/de [Drug Effects]
+ *Myocardial Contraction/de [Drug Effects]
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Prediabetic State/co [Complications]
+ *Prediabetic State/dt [Drug Therapy]
+ Prediabetic State/me [Metabolism]
+ Sodium-Glucose Transporter 2/me [Metabolism]
+ *Sodium-Glucose Transporter 2 Inhibitors/pd [Pharmacology]
+ *Ventricular Function, Left/de [Drug Effects]
+Keyword Heading
+ Coronary
+ Endothelial
+ Microvascular
+ Prediabetes
+ SGLT2
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) is the first class of anti-diabetes treatment that reduces mortality and risk for hospitalization due to heart failure. In clinical studies it has been shown that SGLT2i's promote a general shift to fasting state metabolism characterized by reduced body weight and blood glucose, increase in glucagon/insulin ratio and modest increase in blood ketone levels. Therefore, we investigated the connection between metabolic changes and cardiovascular function in the ob/ob-/- mice; a rodent model of early diabetes with specific focus on coronary microvascular function. Due to leptin deficiency these mice develop metabolic syndrome/diabetes and hepatic steatosis. They also develop cardiac contractile and microvascular dysfunction and are thus a promising model for translational studies of cardiometabolic diseases. We investigated whether this mouse model responded in a human-like manner to empagliflozin treatment in terms of metabolic parameters and tested the hypothesis that it could exert direct effects on coronary microvascular function and contractile performance.
+
+ METHODS: Lean, ob/ob-/- untreated and ob/ob-/- treated with SGLT2i were followed for 10 weeks. Coronary flow velocity reserve (CFVR) and fractional area change (FAC) were monitored with non-invasive Doppler ultrasound imaging. Food intake, urinary glucose excursion and glucose control via HbA1c measurements were followed throughout the study. Liver steatosis was assessed by histology and metabolic parameters determined at the end of the study.
+
+ RESULTS: Sodium-glucose cotransporter 2 inhibitors treatment of ob/ob-/- animals resulted in a switch to a more catabolic state as observed in clinical studies: blood cholesterol and HbA1c were decreased whereas glucagon/insulin ratio and ketone levels were increased. SGLT2i treatment reduced liver triglyceride, steatosis and alanine aminotransferase, an indicator for liver dysfunction. L-Arginine/ADMA ratio, a marker for endothelial function was increased. SGLT2i treatment improved both cardiac contractile function and coronary microvascular function as indicated by improvement of FAC and CFVR, respectively.
+
+ CONCLUSIONS: Sodium-glucose cotransporter 2 inhibitors treatment of ob/ob-/- mice mimics major clinical findings regarding metabolism and cardiovascular improvements and is thus a useful translational model. We demonstrate that SGLT2 inhibition improves coronary microvascular function and contractile performance, two measures with strong predictive values in humans for CV outcome, alongside with the known metabolic changes in a preclinical model for prediabetes and heart failure.
+Registry Number/Name of Substance
+ 0 (Benzhydryl Compounds). 0 (Biomarkers). 0 (Glucosides). 0 (Slc5a2 protein, mouse). 0 (Sodium-Glucose Transporter 2). 0 (Sodium-Glucose Transporter 2 Inhibitors). HDC1R2M35U (empagliflozin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12933-019-0820-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adingupu&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=SGLT2+inhibition+with+empagliflozin+improves+coronary+microvascular+function+and+cardiac+contractility+in+prediabetic+ob%2Fob-%2F-+mice.&volume=18&issue=1&spage=16&epage=&date=2019&doi=10.1186%2Fs12933-019-0820-6&pmid=30732594&sid=OVID:medline
+
+<1780>
+Unique Identifier
+ 30729712
+Title
+ The adipo-fibrokine activin A is associated with metabolic abnormalities and left ventricular diastolic dysfunction in obese patients.
+Source
+ ESC heart failure. 6(2):362-370, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zeller J; Kruger C; Lamounier-Zepter V; Sag S; Strack C; Mohr M; Loew T; Schmitz G; Maier L; Fischer M; Baessler A
+Authors Full Name
+ Zeller, Judith; Kruger, Carolin; Lamounier-Zepter, Valeria; Sag, Sabine; Strack, Christina; Mohr, Margareta; Loew, Thomas; Schmitz, Gerd; Maier, Lars; Fischer, Marcus; Baessler, Andrea.
+Institution
+ Zeller, Judith. Clinic of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany.
+ Kruger, Carolin. Clinic of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany.
+ Lamounier-Zepter, Valeria. Medical Clinic III, Dresden University of Technology, Dresden, Germany.
+ Sag, Sabine. Clinic of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany.
+ Strack, Christina. Clinic of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany.
+ Mohr, Margareta. Clinic of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany.
+ Loew, Thomas. Department of Psychosomatics, University Hospital of Regensburg, Regensburg, Germany.
+ Schmitz, Gerd. Institute for Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg, Regensburg, Germany.
+ Maier, Lars. Clinic of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany.
+ Fischer, Marcus. Clinic of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany.
+ Baessler, Andrea. Clinic of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany.
+MeSH Subject Headings
+ *Activins/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Diastole
+ Echocardiography
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ Follow-Up Studies
+ Heart Ventricles/dg [Diagnostic Imaging]
+ *Heart Ventricles/pp [Physiopathology]
+ Humans
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/et [Etiology]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Prospective Studies
+ Risk Factors
+ *Ventricular Dysfunction, Left/bl [Blood]
+ Ventricular Dysfunction, Left/et [Etiology]
+ Ventricular Dysfunction, Left/pp [Physiopathology]
+ Young Adult
+Keyword Heading
+ *Activin A
+ *Diastolic dysfunction
+ *Epicardial fat
+ *Metabolic syndrome
+ *Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Left ventricular diastolic dysfunction (LVDD) is common in obese subjects, and a relationship between epicardial adipose tissue (EAT), increased adipocytokines, and cardiovascular diseases has been reported. This study sought to examine as to whether the adipo-fibrokine activin A is a link between increased EAT, the metabolic syndrome (MetS), and LVDD in severely obese subjects.
+
+ METHODS AND RESULTS: In 236 obese subjects (o body mass index 39.8 +/- 7.9 kg/m2 ) with a variable degree of the MetS and in 60 healthy non-obese controls (o body mass index 24.8 +/- 3.4 kg/m2 ), serum activin A levels were measured and correlated with parameters of the MetS, epicardial fat thickness (EFT), and echocardiographic parameters of LVDD. Activin A levels were higher in obese than in non-obese subjects (362 +/- 124 vs. 301 +/- 94 pg/mL, P = 0.0004), increased with the number of MetS components (from 285 +/- 82 with no MetS component, 323 +/- 94 with one or two MetS components, to 403 +/- 131 pg/mL with >=3 MetS components, P < 0.0001) and correlated with EFT (r = 0.41, P < 0.001). Furthermore, activin A levels were related to several parameters of LVDD [e.g. left atrial size (382 +/- 117 vs. 352 125 pg/mL, P = 0.024), E/e' (394 +/- 108 vs. 356 +/- 127 pg/mL, P = 0.005)]. LVDD was highest in MetS obese subjects with high EFT (44.3%) compared with MetS obese subjects with low EFT (27.0%), non-MetS obese subjects with high EFT (24.2%), and non-MetS obese subjects with low EFT (10.6%, P < 0.0001).
+
+ CONCLUSIONS: In severe obesity, activin A was significantly related to EFT, MetS, and LVDD, implicating MetS-related alterations in the secretory profile of EAT in the pathogenesis of obesity-related heart disease. Copyright © 2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (activin A). 104625-48-1 (Activins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fehf2.12409
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zeller&issn=2055-5822&title=ESC+heart+failure&atitle=The+adipo-fibrokine+activin+A+is+associated+with+metabolic+abnormalities+and+left+ventricular+diastolic+dysfunction+in+obese+patients.&volume=6&issue=2&spage=362&epage=370&date=2019&doi=10.1002%2Fehf2.12409&pmid=30729712&sid=OVID:medline
+
+<1781>
+Unique Identifier
+ 30723473
+Title
+ Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice.
+Source
+ Frontiers in Immunology. 10:17, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ohkura T; Yoshimura T; Fujisawa M; Ohara T; Marutani R; Usami K; Matsukawa A
+Authors Full Name
+ Ohkura, Takahiro; Yoshimura, Teizo; Fujisawa, Masayoshi; Ohara, Toshiaki; Marutani, Rie; Usami, Kaya; Matsukawa, Akihiro.
+Institution
+ Ohkura, Takahiro. Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
+ Yoshimura, Teizo. Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
+ Fujisawa, Masayoshi. Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
+ Ohara, Toshiaki. Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
+ Marutani, Rie. Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
+ Usami, Kaya. Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
+ Matsukawa, Akihiro. Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Animals
+ Biomarkers
+ Biopsy
+ Cytokines/me [Metabolism]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ *Disease Susceptibility
+ Dyslipidemias/et [Etiology]
+ Dyslipidemias/me [Metabolism]
+ Fatty Acids/me [Metabolism]
+ Hypertrophy
+ Insulin Resistance
+ Lipid Metabolism
+ Lipolysis
+ MAP Kinase Signaling System
+ Macrophages/me [Metabolism]
+ Mice
+ Mice, Knockout
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Panniculitis/dg [Diagnostic Imaging]
+ *Panniculitis/et [Etiology]
+ *Panniculitis/me [Metabolism]
+ Panniculitis/pa [Pathology]
+ *Repressor Proteins/ge [Genetics]
+ Repressor Proteins/me [Metabolism]
+ X-Ray Microtomography
+Keyword Heading
+ Ras/Raf/ERK/MAPK
+ Spred2
+ adipocyte
+ inflammation
+ macrophage
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Chronic low-grade inflammation in visceral adipose tissues triggers the development of obesity-related insulin resistance, leading to the metabolic syndrome, a serious health condition with higher risk of cardiovascular disease, diabetes, and stroke. In the present study, we investigated whether Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, plays a role in the development of high fat diet (HFD)-induced obesity, adipose tissue inflammation, metabolic abnormalities, and insulin resistance. Spred2 knockout (KO) mice, fed with HFD, exhibited an augmented body weight gain, which was associated with enhanced adipocyte hypertrophy in mesenteric white adipose tissue (mWAT) and deteriorated dyslipidemia, compared with wild-type (WT) controls. The number of infiltrating macrophages with a M1 phenotype, and the crown-like structures, composed of macrophages surrounding dead or dying adipocytes, were more abundant in Spred2 KO-mWAT compared to in WT-mWAT. Exacerbated adipose tissue inflammation in Spred2 KO mice led to aggravated insulin resistance and fatty liver disease. To analyze the mechanism(s) that caused adipose tissue inflammation, cytokine response in mWAT was investigated. Stromal vascular fraction that contained macrophages from Spred2 KO-mWAT showed elevated levels of tumor necrosis factor alpha (TNFalpha) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared with those from WT-mWAT. Upon stimulation with palmitate acid (PA), bone marrow-derived macrophages (BMDMs) derived from Spred2 KO mice secreted higher levels of TNFalpha and MCP-1 than those from WT mice with enhanced ERK activation. U0126, a MEK inhibitor, reduced the PA-induced cytokine response. Taken together, these results suggested that Spred2, in macrophages, negatively regulates high fat diet-induced obesity, adipose tissue inflammation, metabolic abnormalities, and insulin resistance by inhibiting the ERK/MAPK pathway. Thus, Spred2 represents a potential therapeutic tool for the prevention of insulin resistance and resultant metabolic syndrome.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Fatty Acids). 0 (Repressor Proteins). 0 (Spred2 protein, mouse).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3389%2ffimmu.2019.00017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ohkura&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Spred2+Regulates+High+Fat+Diet-Induced+Adipose+Tissue+Inflammation%2C+and+Metabolic+Abnormalities+in+Mice.&volume=10&issue=&spage=17&epage=&date=2019&doi=10.3389%2Ffimmu.2019.00017&pmid=30723473&sid=OVID:medline
+
+<1782>
+Unique Identifier
+ 30722060
+Title
+ Circulating metabolites associated with objectively measured sleep duration and sleep variability in overweight/obese participants: a metabolomics approach within the SATIN study.
+Source
+ Sleep. 42(5), 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Papandreou C; Camacho-Barcia L; Garcia-Gavilan J; Hansen TT; Hjorth MF; Halford JCG; Salas-Salvado J; Sjodin A; Bullo M
+Authors Full Name
+ Papandreou, Christopher; Camacho-Barcia, Lucia; Garcia-Gavilan, Jesus; Hansen, Thea Toft; Hjorth, Mads F; Halford, Jason C G; Salas-Salvado, Jordi; Sjodin, Anders; Bullo, Monica.
+Institution
+ Papandreou, Christopher. Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Rovira i Virgili University, Reus, Spain.
+ Papandreou, Christopher. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Camacho-Barcia, Lucia. Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Rovira i Virgili University, Reus, Spain.
+ Camacho-Barcia, Lucia. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Garcia-Gavilan, Jesus. Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Rovira i Virgili University, Reus, Spain.
+ Garcia-Gavilan, Jesus. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Hansen, Thea Toft. Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
+ Hjorth, Mads F. Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
+ Halford, Jason C G. Department of Psychological Sciences, Institute of Psychology Health and Society, University of Liverpool, Liverpool, UK.
+ Salas-Salvado, Jordi. Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Rovira i Virgili University, Reus, Spain.
+ Salas-Salvado, Jordi. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Sjodin, Anders. Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
+ Bullo, Monica. Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Rovira i Virgili University, Reus, Spain.
+ Bullo, Monica. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Magnetic Resonance Spectroscopy/mt [Methods]
+ Male
+ *Metabolomics/mt [Methods]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Overweight/bl [Blood]
+ Overweight/di [Diagnosis]
+ Overweight/ep [Epidemiology]
+ *Satiation/ph [Physiology]
+ *Sleep/ph [Physiology]
+Keyword Heading
+ SATIN
+ metabolomics
+ sleep duration
+ sleep variability
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ STUDY OBJECTIVES: To investigate the associations of circulating metabolites with sleep duration and sleep variability. We also assessed the ability of metabolites to discriminate between sleep duration and sleep variability categories.
+
+ METHODS: Cross-sectional analyses were performed on baseline data from 205 participants with overweight/obesity in the "Satiety Innovation" (SATIN) study. A targeted metabolite profiling (n = 159 metabolites) approach was applied using three different platforms (nuclear magnetic resonance, liquid chromatography coupled to mass spectrometry, and gas chromatography coupled to mass spectrometry). Associations between circulating metabolite concentrations and accelerometer-derived sleep duration and variability in sleep duration were assessed using elastic-net regression analysis. Ten-fold cross-validation was used to estimate the discriminative accuracy of metabolites for sleep duration and sleep variability categories.
+
+ RESULTS: A metabolite profile, including acyl-carnitines (C11:0/C5:1-DC/iso-C11:0, 2-M-C4:1/3-M-C4:1, C4:0), sphingomyelins (42:1, 33:1), glycerol, stearic acid, 2- and 3- hydroxyl-butyric acid, docosahexaenoic acid, serotonin, and phosphatidylcholine (34:2), was significantly associated with high sleep duration (4th plus 5th quintile). Ten metabolites, including acyl-carnitines (C18:1, C7:0, C6-OH), phosphatidylcholine (40:6, 37:4, 42:5), lyso-phosphatidylcholine (20:1), sucrose, glutamic acid, and triacylglycerol (52:4), were significantly associated with high sleep variability (4th plus 5th quintile). The area under the curve was 0.69 (95% CI: 0.62-0.75) and 0.63 (95% CI: 0.53-0.72) in the multimetabolite score for high sleep duration and sleep variability, respectively. The variance in sleep duration explained by metabolites was 7%. No metabolites were selected for prediction of sleep variability (continuous).
+
+ CONCLUSIONS: A small set of metabolites within distinct biochemical pathways were associated with high sleep duration and sleep variability. These metabolites appeared to moderately discriminate sleep duration and sleep variability categories. Copyright © Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fsleep%2fzsz030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Papandreou&issn=0161-8105&title=Sleep&atitle=Circulating+metabolites+associated+with+objectively+measured+sleep+duration+and+sleep+variability+in+overweight%2Fobese+participants%3A+a+metabolomics+approach+within+the+SATIN+study.&volume=42&issue=5&spage=zsz030&epage=&date=2019&doi=10.1093%2Fsleep%2Fzsz030&pmid=30722060&sid=OVID:medline
+
+<1783>
+Unique Identifier
+ 30720127
+Title
+ Colonic M1 macrophage is associated with the prolongation of gastrointestinal motility and obesity in mice treated with vancomycin.
+Source
+ Molecular Medicine Reports. 19(4):2591-2598, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Inoue Y; Fukui H; Xu X; Ran Y; Tomita T; Oshima T; Watari J; Miwa H
+Authors Full Name
+ Inoue, Yoshihito; Fukui, Hirokazu; Xu, Xin; Ran, Ying; Tomita, Toshihiko; Oshima, Tadayuki; Watari, Jiro; Miwa, Hiroto.
+Institution
+ Inoue, Yoshihito. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
+ Fukui, Hirokazu. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
+ Xu, Xin. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
+ Ran, Ying. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
+ Tomita, Toshihiko. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
+ Oshima, Tadayuki. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
+ Watari, Jiro. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
+ Miwa, Hiroto. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
+MeSH Subject Headings
+ Animals
+ B7-1 Antigen/me [Metabolism]
+ Biomarkers
+ *Colon/de [Drug Effects]
+ *Colon/im [Immunology]
+ Colon/me [Metabolism]
+ Colon/pp [Physiopathology]
+ Cytokines/me [Metabolism]
+ Disease Models, Animal
+ Female
+ *Gastrointestinal Motility/de [Drug Effects]
+ Immunohistochemistry
+ *Macrophages/im [Immunology]
+ Macrophages/me [Metabolism]
+ Mice
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Tetraspanin 30/me [Metabolism]
+ *Vancomycin/pd [Pharmacology]
+Abstract
+ Gut microbiota plays a pivotal role in not only the gastrointestinal (GI) immune system but also GI motility and metabolism. Antibiotic treatments are likely to affect the gut flora and GI immune system, subsequently disturbing GI motility and body metabolism. In the present study, we investigated antibiotic-induced alterations of body metabolism and GI motility in association with the macrophage profile in the colon. Specific pathogen-free (SPF) mice (ICR; 6 weeks old; female) were orally administered vancomycin (0.2 mg/ml) in drinking water for 5 weeks, and subsequent changes in pathophysiology were observed. The expression of CD80 and CD163 was examined by immunohistochemistry and the expression of cytokines in colonic tissues was evaluated by reverse transcription-quantitative polymerase chain reaction. The gastrointestinal transit time (GITT) was measured by administration of carmine red (6% w/v) solution. In the vancomycin-treated SPF mice, significant increases in body weight, cecum weight and GITT were observed compared with the controls. The number of CD80-positive M1 macrophages and the expression of interferon-gamma and interleukin-12 were significantly increased, whereas, the numbers of CD163-positive M2 macrophages in the mucosal and muscular layers were decreased in the colon of vancomycin-treated mice. GITT was positively correlated with the number of CD80-positive M1 macrophages in the colonic mucosa; however, was negatively correlated with the number of CD163-positive M2 macrophages in the mucosal and muscular layers. Therefore, it was suggested that antibiotic treatment affects body metabolism and GI motility, accompanied by alterations in macrophage polarization and cytokine profiles in the colon.
+Registry Number/Name of Substance
+ 0 (B7-1 Antigen). 0 (Biomarkers). 0 (Cytokines). 0 (Tetraspanin 30). 6Q205EH1VU (Vancomycin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3892%2fmmr.2019.9920
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Inoue&issn=1791-2997&title=Molecular+Medicine+Reports&atitle=Colonic+M1+macrophage+is+associated+with+the+prolongation+of+gastrointestinal+motility+and+obesity+in+mice+treated+with+vancomycin.&volume=19&issue=4&spage=2591&epage=2598&date=2019&doi=10.3892%2Fmmr.2019.9920&pmid=30720127&sid=OVID:medline
+
+<1784>
+Unique Identifier
+ 30718144
+Title
+ GDF15 reflects beta cell function in obese patients independently of the grade of impairment of glucose metabolism.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 29(4):334-342, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schernthaner-Reiter MH; Itariu BK; Krebs M; Promintzer-Schifferl M; Stulnig TM; Tura A; Anderwald CH; Clodi M; Ludvik B; Pacini G; Luger A; Vila G
+Authors Full Name
+ Schernthaner-Reiter, M H; Itariu, B K; Krebs, M; Promintzer-Schifferl, M; Stulnig, T M; Tura, A; Anderwald, C H; Clodi, M; Ludvik, B; Pacini, G; Luger, A; Vila, G.
+Institution
+ Schernthaner-Reiter, M H. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address: marie.schernthaner-reiter@meduniwien.ac.at.
+ Itariu, B K. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
+ Krebs, M. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
+ Promintzer-Schifferl, M. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
+ Stulnig, T M. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
+ Tura, A. Metabolic Unit, Institute of Neuroscience, National Research Council, Padova, Italy.
+ Anderwald, C H. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Metabolic Unit, Institute of Neuroscience, National Research Council, Padova, Italy.
+ Clodi, M. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
+ Ludvik, B. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Department of Medicine 1 and Karl Landsteiner Institute for Obesity and Metabolic Disorders, Rudolfstiftung Hospital, Vienna, Austria.
+ Pacini, G. Metabolic Unit, Institute of Neuroscience, National Research Council, Padova, Italy.
+ Luger, A. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
+ Vila, G. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Female
+ *Glucose Intolerance/bl [Blood]
+ Glucose Intolerance/di [Diagnosis]
+ Glycated Hemoglobin/me [Metabolism]
+ *Growth Differentiation Factor 15/bl [Blood]
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ *Insulin-Secreting Cells/me [Metabolism]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Prognosis
+ Young Adult
+Keyword Heading
+ Biomarker
+ Cardiovascular risk marker
+ Diabetes
+ Impaired glucose metabolism
+ Predictor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Growth differentiation factor 15 (GDF15) is a strong predictor of cardiovascular morbidity and mortality found to be both marker and target of impaired glucose metabolism. GDF15 increases following glucose administration and is up-regulated in obesity and diabetes. We investigate here the relationship between GDF15 and beta cell function.
+
+ METHODS AND RESULTS: In this cross-sectional study we evaluated GDF15 concentrations in 160 obese subjects (BMI 35-63 kg/m2, age 39.4 +/- 18.6 years, m/f 38/122) who underwent a 75 g oral glucose tolerance test (OGTT). Based on the OGTT results, the cohort was divided into two groups: 1) normal fasting glucose and normal glucose tolerance (n = 80), 2) impaired fasting glucose, impaired glucose tolerance or type 2 diabetes (n = 80). The relationship of GDF15 to fasting and OGTT-based dynamic insulin sensitivity and insulin secretion parameters was evaluated. GDF15 was higher in the prediabetes and diabetes groups and correlated with HbA1c, glucose, insulin as well as baseline and dynamic indices of insulin sensitivity and estimated beta cell function. Multiple regression analysis revealed that age, waist-to-height ratio, glomerular filtration rate and prehepatic beta cell function, but not the grade of impairment of glucose metabolism, were independent predictors of GDF15. Subgroup analysis showed that of all parameters of glucose metabolism only C-peptide, fasting prehepatic beta cell function and insulinogenic index remained significantly related to GDF15 in both groups.
+
+ CONCLUSION: We conclude that in patients with severe obesity, GDF15 strongly relates to beta cell function and should be further investigated as a potential therapeutic target and biomarker guiding treatment options. Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (GDF15 protein, human). 0 (Glycated Hemoglobin A). 0 (Growth Differentiation Factor 15). 0 (Insulin). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.numecd.2018.12.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schernthaner-Reiter&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=GDF15+reflects+beta+cell+function+in+obese+patients+independently+of+the+grade+of+impairment+of+glucose+metabolism.&volume=29&issue=4&spage=334&epage=342&date=2019&doi=10.1016%2Fj.numecd.2018.12.008&pmid=30718144&sid=OVID:medline
+
+<1785>
+Unique Identifier
+ 30717355
+Title
+ Association between Sleep Disturbances and Liver Status in Obese Subjects with Nonalcoholic Fatty Liver Disease: A Comparison with Healthy Controls.
+Source
+ Nutrients. 11(2), 2019 Feb 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Marin-Alejandre BA; Abete I; Cantero I; Riezu-Boj JI; Milagro FI; Monreal JI; Elorz M; Herrero JI; Benito-Boillos A; Quiroga J; Martinez-Echeverria A; Uriz-Otano JI; Huarte-Muniesa MP; Tur JA; Martinez JA; Zulet MA
+Author NameID
+ Abete, Itziar; ORCID: https://orcid.org/0000-0002-6475-5387
+ Riezu-Boj, Jose I; ORCID: https://orcid.org/0000-0002-1885-8457
+ Milagro, Fermin I; ORCID: https://orcid.org/0000-0002-3228-9916
+ Tur, Josep A; ORCID: https://orcid.org/0000-0002-6940-0761
+ Martinez, J Alfredo; ORCID: https://orcid.org/0000-0001-5218-6941
+Authors Full Name
+ Marin-Alejandre, Bertha Araceli; Abete, Itziar; Cantero, Irene; Riezu-Boj, Jose I; Milagro, Fermin I; Monreal, J Ignacio; Elorz, Mariana; Herrero, Jose Ignacio; Benito-Boillos, Alberto; Quiroga, Jorge; Martinez-Echeverria, Ana; Uriz-Otano, Juan Isidro; Huarte-Muniesa, Maria Pilar; Tur, Josep A; Martinez, J Alfredo; Zulet, M Angeles.
+Institution
+ Marin-Alejandre, Bertha Araceli. Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain. bmarin.1@alumni.unav.es.
+ Abete, Itziar. Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain. iabetego@unav.es.
+ Abete, Itziar. Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. iabetego@unav.es.
+ Cantero, Irene. Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain. icgonzalez@unav.es.
+ Riezu-Boj, Jose I. Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain. jiriezu@unav.es.
+ Riezu-Boj, Jose I. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. jiriezu@unav.es.
+ Milagro, Fermin I. Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain. fmilagro@unav.es.
+ Milagro, Fermin I. Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. fmilagro@unav.es.
+ Milagro, Fermin I. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. fmilagro@unav.es.
+ Monreal, J Ignacio. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. jimonreal@unav.es.
+ Monreal, J Ignacio. Clinical Chemistry Department, Clinica Universidad de Navarra 31008, Pamplona, Spain. jimonreal@unav.es.
+ Elorz, Mariana. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. marelorz@unav.es.
+ Elorz, Mariana. Department of Radiology, Clinica Universidad de Navarra 31008, Pamplona, Spain. marelorz@unav.es.
+ Herrero, Jose Ignacio. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. iherrero@unav.es.
+ Herrero, Jose Ignacio. Liver Unit, Clinica Universidad de Navarra 31008, Pamplona, Spain. iherrero@unav.es.
+ Herrero, Jose Ignacio. Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBERehd), 28029 Madrid, Spain. iherrero@unav.es.
+ Benito-Boillos, Alberto. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. albenitob@unav.es.
+ Benito-Boillos, Alberto. Department of Radiology, Clinica Universidad de Navarra 31008, Pamplona, Spain. albenitob@unav.es.
+ Quiroga, Jorge. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. jquiroga@unav.es.
+ Quiroga, Jorge. Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBERehd), 28029 Madrid, Spain. jquiroga@unav.es.
+ Quiroga, Jorge. Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain. jquiroga@unav.es.
+ Martinez-Echeverria, Ana. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. ana.martinez.echeverria@cfnavarra.es.
+ Martinez-Echeverria, Ana. Department of Gastroenterology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain. ana.martinez.echeverria@cfnavarra.es.
+ Uriz-Otano, Juan Isidro. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. jurizota@cfnavarra.es.
+ Uriz-Otano, Juan Isidro. Department of Gastroenterology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain. jurizota@cfnavarra.es.
+ Huarte-Muniesa, Maria Pilar. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. phuartem@cfnavarra.es.
+ Huarte-Muniesa, Maria Pilar. Department of Gastroenterology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain. phuartem@cfnavarra.es.
+ Tur, Josep A. Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. pep.tur@uib.es.
+ Tur, Josep A. Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, 07122 Palma, Spain. pep.tur@uib.es.
+ Martinez, J Alfredo. Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain. jalfmtz@unav.es.
+ Martinez, J Alfredo. Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. jalfmtz@unav.es.
+ Martinez, J Alfredo. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. jalfmtz@unav.es.
+ Martinez, J Alfredo. Madrid Institute of Advanced Studies (IMDEA Food), 28049 Madrid, Spain. jalfmtz@unav.es.
+ Zulet, M Angeles. Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain. mazulet@unav.es.
+ Zulet, M Angeles. Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. mazulet@unav.es.
+ Zulet, M Angeles. Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain. mazulet@unav.es.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ *Body Mass Index
+ *Body Weight
+ Case-Control Studies
+ Female
+ Hardness
+ Humans
+ Liver/en [Enzymology]
+ *Liver/pa [Pathology]
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ *Obesity/co [Complications]
+ Odds Ratio
+ Overweight
+ *Sleep
+ *Sleep Wake Disorders/co [Complications]
+ Transaminases/bl [Blood]
+Keyword Heading
+ NAFLD
+ Obesity
+ Pittsburgh Sleep Quality Index
+ sleep
+ sleep disruption
+ sleep duration
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The relevance of sleep patterns in the onset or evolution of nonalcoholic fatty liver disease (NAFLD) is still poorly understood. Our aim was to investigate the association between sleep characteristics and hepatic status indicators in obese people with NAFLD compared to normal weight non-NAFLD controls. Ninety-four overweight or obese patients with NAFLD and 40 non-NAFLD normal weight controls assessed by abdominal ultrasonography were enrolled. Hepatic status evaluation considered liver stiffness determined by Acoustic Radiation Force Impulse elastography (ARFI) and transaminases. Additionally, anthropometric measurements, clinical characteristics, and biochemical profiles were determined. Sleep features were evaluated using the Pittsburgh Sleep Quality Index (PSQI). Hepatic status parameters, anthropometric measurements, and clinical and biochemical markers differed significantly in NAFLD subjects compared to controls, as well as sleep efficiency, sleep disturbance score, and sleep quality score. In the NAFLD group, a higher prevalence of short sleep duration (p = 0.005) and poor sleep quality (p = 0.041) were found. Multivariate-adjusted odds ratio (95% confidence interval) for NAFLD considering sleep disturbance was 1.59 (1.11-2.28). Regression models that included either sleep disturbance or sleep quality predicted up to 20.3% and 20.4% of the variability of liver stiffness, respectively, and after adjusting for potential confounders. Current findings suggest that sleep disruption may be contributing to the pathogenesis of NAFLD as well as the alteration of the liver may be affecting sleep patterns. Consequently, sleep characteristics may be added to the list of modifiable behaviors to consider in health promotion strategies and in the prevention and management of NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1 (Transaminases).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11020322
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Marin-Alejandre&issn=2072-6643&title=Nutrients&atitle=Association+between+Sleep+Disturbances+and+Liver+Status+in+Obese+Subjects+with+Nonalcoholic+Fatty+Liver+Disease%3A+A+Comparison+with+Healthy+Controls.&volume=11&issue=2&spage=&epage=&date=2019&doi=10.3390%2Fnu11020322&pmid=30717355&sid=OVID:medline
+
+<1786>
+Unique Identifier
+ 30715588
+Title
+ Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study.
+Source
+ European Radiology. 29(9):4968-4979, 2019 Sep.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Santoro A; Guidarelli G; Ostan R; Giampieri E; Fabbri C; Bertarelli C; Nicoletti C; Kadi F; de Groot LCPGM; Feskens E; Berendsen A; Brzozowska A; Januszko O; Kozlowska K; Fairweather-Tait S; Jennings A; Meunier N; Caumon E; Napoli A; Mercatelli D; Battista G; Capri M; Franceschi C; Bazzocchi A
+Authors Full Name
+ Santoro, Aurelia; Guidarelli, Giulia; Ostan, Rita; Giampieri, Enrico; Fabbri, Cristina; Bertarelli, Claudia; Nicoletti, Claudio; Kadi, Fawzi; de Groot, Lisette C P G M; Feskens, Edith; Berendsen, Agnes; Brzozowska, Anna; Januszko, Olga; Kozlowska, Katarzyna; Fairweather-Tait, Susan; Jennings, Amy; Meunier, Nathalie; Caumon, Elodie; Napoli, Alessandro; Mercatelli, Daniele; Battista, Giuseppe; Capri, Miriam; Franceschi, Claudio; Bazzocchi, Alberto.
+Institution
+ Santoro, Aurelia. Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy. aurelia.santoro@unibo.it.
+ Santoro, Aurelia. C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy. aurelia.santoro@unibo.it.
+ Guidarelli, Giulia. Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
+ Ostan, Rita. Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
+ Ostan, Rita. C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy.
+ Giampieri, Enrico. Department of Physics, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
+ Fabbri, Cristina. Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
+ Fabbri, Cristina. C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy.
+ Bertarelli, Claudia. Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
+ Nicoletti, Claudio. Department of Experimental and Clinical Medicine, Section of Anatomy, University of Florence, Florence, Italy.
+ Nicoletti, Claudio. Gut Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich, UK.
+ Kadi, Fawzi. School of Health and Medical Sciences, Orebro University, Orebro, Sweden.
+ de Groot, Lisette C P G M. Department of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
+ Feskens, Edith. Department of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
+ Berendsen, Agnes. Department of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
+ Brzozowska, Anna. Department of Human Nutrition, WULS-SGGW, Warsaw, Poland.
+ Januszko, Olga. Department of Human Nutrition, WULS-SGGW, Warsaw, Poland.
+ Kozlowska, Katarzyna. Department of Human Nutrition, WULS-SGGW, Warsaw, Poland.
+ Fairweather-Tait, Susan. Norwich Medical School, University of East Anglia, Norwich, UK.
+ Jennings, Amy. Norwich Medical School, University of East Anglia, Norwich, UK.
+ Meunier, Nathalie. CHU Clermont-Ferrand, CRNH Auvergne, 63000, Clermont-Ferrand, France.
+ Caumon, Elodie. CHU Clermont-Ferrand, CRNH Auvergne, 63000, Clermont-Ferrand, France.
+ Napoli, Alessandro. Radiology Section, Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
+ Mercatelli, Daniele. Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
+ Battista, Giuseppe. Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
+ Capri, Miriam. Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
+ Capri, Miriam. C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy.
+ Franceschi, Claudio. Institute of Neurological Sciences (IRCCS), Bologna, Italy.
+ Bazzocchi, Alberto. Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. abazzo@inwind.it.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ *Adiposity
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Composition
+ *Bone Density
+ Cross-Sectional Studies
+ Europe
+ Female
+ Humans
+ *Inflammation/pp [Physiopathology]
+ *Inflammation Mediators/bl [Blood]
+ Male
+ Muscle, Skeletal/dg [Diagnostic Imaging]
+ Obesity/pp [Physiopathology]
+ Sarcopenia/pp [Physiopathology]
+ Sex Factors
+Keyword Heading
+ Aging
+ Body composition
+ DXA
+ Inflammation
+ Sarcopenia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.
+
+ METHODS: A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65-79 years) women and men from five European countries of the "New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe" project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Ralpha, TNF-alpha, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-beta1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays.
+
+ RESULTS: BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-beta1, TNF-alpha, IL-6Ralpha, glycoprotein 130, TNF-alpha-R1, and TNF-alpha-R2.
+
+ CONCLUSIONS: The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.
+
+ KEY POINTS: * Body composition markers concordantly associated positively or negatively with adipose-related and inflammatory markers, with the exception of skeletal muscle mass index. * No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-beta1, TNF-alpha, IL-6Ralpha, gp130, TNF-alpha-R1, and TNF-alpha-R2. * Skeletal muscle mass index (SMI) shows a good correlation with inflammatory profile in age-related sarcopenia.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00330-018-5973-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Santoro&issn=0938-7994&title=European+Radiology&atitle=Gender-specific+association+of+body+composition+with+inflammatory+and+adipose-related+markers+in+healthy+elderly+Europeans+from+the+NU-AGE+study.&volume=29&issue=9&spage=4968&epage=4979&date=2019&doi=10.1007%2Fs00330-018-5973-2&pmid=30715588&sid=OVID:medline
+
+<1787>
+Unique Identifier
+ 30712418
+Title
+ Obesity-related heart failure with preserved ejection fraction: new treatment strategies. [Review]
+Source
+ Hospital practice (1995) Hospital practice. 47(2):67-72, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chrysant SG; Chrysant GS
+Authors Full Name
+ Chrysant, Steven G; Chrysant, George S.
+Institution
+ Chrysant, Steven G. a Department of Cardiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
+ Chrysant, George S. b Department of Cardiology, INTEGRIS Baptist Medical Center, Oklahoma City, OK, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Causality
+ Comorbidity
+ *Coronary Circulation/ph [Physiology]
+ Female
+ Heart Failure/bl [Blood]
+ Heart Failure/ep [Epidemiology]
+ *Heart Failure/pp [Physiopathology]
+ Humans
+ Male
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ *Stroke Volume/ph [Physiology]
+ United States
+Keyword Heading
+ HFpEF
+ Obesity
+ SGLT2 inhibitors
+ diabetes
+ neprilysin inhibitors
+ treatment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Obesity has risen in the US and worldwide, and has become a major risk factor for type 2 diabetes mellitus (T2DM), hypertension, cardiovascular disease, and mostly HF with preserved ejection fraction (HFpEF). Also, the prevalence of HF is quite high in the US accounting for 6.6 million adults at present and is projected to reach 8.5 million by the year 2030 and is equally divided between HFpEF and heart failure reduced ejection fraction (HFrEF). Patients with HFpEF are resistant to treatment with drugs usually used for the treatment of HFrEF, but the reasons for this resistance are not clearly known.
+
+ METHODS: In order to get a better perspective on the current status of the underlying pathophysiology and treatment of patients with HFpEF, a Medline search of the English language literature was conducted between 2015 and 2018 using the terms obesity, HFpEF, diabetes, treatment, SGLT2 inhibitors, and neprilysin inhibitors and 24 pertinent papers were selected.
+
+ RESULTS: The review of these papers revealed that patients with HFpEF have expanded plasma volume, restricted left ventricular distension with increased end-diastolic volume and depressed natriuretic peptide levels. In this respect, drugs that cause increased diuresis and natriuresis should a reasonable choice to treat these patients. The recently FDA approved sodium-glucose cotransporter-2 (SGLT2) inhibitors for the treatment of T2DM, are a good choice, for the treatment of HFpEF, since they cause osmotic diuresis from glucose excretion and increase salt and water excretion and decrease plasma volume. In addition, they produce loss of calories leading to weight and blood pressure reduction and have shown to prevent the new onset HFpEF and decrease hospitalizations and death from this disease.
+
+ CONCLUSION: The results of this analysis has shown that HFpEF has different pathophysiology from HFrEF and is difficult to treat. Drugs that block renal tubular glucose reabsorption and cause osmotic diuresis and natriuresis could be a good choice to treat patients with HFpEF alone or in combination with diuretics and other drugs.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f21548331.2019.1575662
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chrysant&issn=2154-8331&title=Hospital+practice+%281995%29+Hospital+practice&atitle=Obesity-related+heart+failure+with+preserved+ejection+fraction%3A+new+treatment+strategies.&volume=47&issue=2&spage=67&epage=72&date=2019&doi=10.1080%2F21548331.2019.1575662&pmid=30712418&sid=OVID:medline
+
+<1788>
+Unique Identifier
+ 30706674
+Title
+ The impact of age and sex on body composition and glucose sensitivity in C57BL/6J mice.
+Source
+ Physiological Reports. 7(3):e13995, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Reynolds TH; Dalton A; Calzini L; Tuluca A; Hoyte D; Ives SJ
+Authors Full Name
+ Reynolds, Thomas H; Dalton, Allison; Calzini, Lucas; Tuluca, Andrei; Hoyte, Dakembay; Ives, Stephen J.
+Institution
+ Reynolds, Thomas H. Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New York.
+ Dalton, Allison. Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New York.
+ Calzini, Lucas. Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New York.
+ Tuluca, Andrei. Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New York.
+ Hoyte, Dakembay. Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New York.
+ Ives, Stephen J. Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New York.
+MeSH Subject Headings
+ Adiposity
+ Age Factors
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Body Composition
+ Energy Metabolism
+ Female
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ *Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ Obesity/pc [Prevention & Control]
+ Protective Factors
+ Risk Factors
+ Sex Factors
+ Time Factors
+ Weight Gain
+Keyword Heading
+ Adiposity
+ body composition
+ glucose metabolism
+ insulin resistance
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ A paucity of data exists regarding sex differences in age-related obesity and insulin resistance, particularly in the preclinical murine model. The purpose of this study was to determine the effects of age and sex on insulin action and body composition in C57BL/6J mice. Aged (AG, 18 months old) male C57BL/6J mice, glucose tolerance was diminished compared to young (YG, 6 months old) male mice (Area Under Curve: 95,103 +/- 6818 vs. 64,005 +/- 2031, P = 0.002). However, there was no age-related decline in glucose or insulin tolerance in females. Body composition analysis revealed that AG males had significantly greater body mass (42.2 +/- 1.9 vs. 30.0 +/- 0.4 g, P < 0.0001), fat mass (18.7 +/- 2.0 vs. 3.3 +/- 0.4 g, P < 0.0001), body fat (43.0 +/- 3.0 vs. 11.0 +/- 1.5%, P < 0.0001) than YG males. In AG females, body mass (32.8 +/- 1.6 vs. 26.3 +/- 0.9 g, P = 0.02) was higher, but fat mass (13.3 +/- 2.0 vs. 9.5 +/- 1.3 g, P = 0.24) and body fat (37.8 +/- 4.8 vs. 35.5 +/- 3.8%, P = 0.67) were similar when compared to YG females. AG males had significantly higher body mass (42.2 +/- 1.9 vs. 32.8 +/- 1.6 g, P = 0.001) and fat mass (18.7 +/- 2.0 vs. 13.3 +/- 2.0 g, P = 0.04) compared to AG females; however, body fat (43.0 +/- 3.0 vs. 37.8 +/- 4.8%, P = 0.28) was similar. Six weeks of treatment with MitoQ, a mitochondrial-targeted antioxidant, did not reverse age-related obesity in male mice. Surprisingly, obesity and insulin resistance appear to be reversed in the oldest of the old male mice (28 vs. 20 months). Our findings indicate that female mice, unlike males, are protected from age-related obesity and insulin resistance. Copyright © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.14814%2fphy2.13995
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Reynolds&issn=2051-817X&title=Physiological+Reports&atitle=The+impact+of+age+and+sex+on+body+composition+and+glucose+sensitivity+in+C57BL%2F6J+mice.&volume=7&issue=3&spage=e13995&epage=&date=2019&doi=10.14814%2Fphy2.13995&pmid=30706674&sid=OVID:medline
+
+<1789>
+Unique Identifier
+ 30704070
+Title
+ A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome.
+Source
+ Nutrients. 11(2), 2019 Jan 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Galmes S; Cifre M; Palou A; Oliver P; Serra F
+Author NameID
+ Galmes, Sebastia; ORCID: https://orcid.org/0000-0002-4243-9527
+ Palou, Andreu; ORCID: https://orcid.org/0000-0002-0295-4452
+ Oliver, Paula; ORCID: https://orcid.org/0000-0002-7821-8806
+ Serra, Francisca; ORCID: https://orcid.org/0000-0002-8307-9732
+Authors Full Name
+ Galmes, Sebastia; Cifre, Margalida; Palou, Andreu; Oliver, Paula; Serra, Francisca.
+Institution
+ Galmes, Sebastia. NUO Group, Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, 07122 Palma, Spain. s.galmes@uib.cat.
+ Galmes, Sebastia. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), 28029 Madrid, Spain. s.galmes@uib.cat.
+ Galmes, Sebastia. Institut d'Investigacio Sanitaria Illes Balears (IdISBa), 07120 Palma, Spain. s.galmes@uib.cat.
+ Cifre, Margalida. NUO Group, Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, 07122 Palma, Spain. marga.cifre@uib.es.
+ Cifre, Margalida. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), 28029 Madrid, Spain. marga.cifre@uib.es.
+ Palou, Andreu. NUO Group, Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, 07122 Palma, Spain. Andreu.palou@uib.es.
+ Palou, Andreu. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), 28029 Madrid, Spain. Andreu.palou@uib.es.
+ Palou, Andreu. Institut d'Investigacio Sanitaria Illes Balears (IdISBa), 07120 Palma, Spain. Andreu.palou@uib.es.
+ Oliver, Paula. NUO Group, Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, 07122 Palma, Spain. paula.oliver@uib.es.
+ Oliver, Paula. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), 28029 Madrid, Spain. paula.oliver@uib.es.
+ Oliver, Paula. Institut d'Investigacio Sanitaria Illes Balears (IdISBa), 07120 Palma, Spain. paula.oliver@uib.es.
+ Serra, Francisca. NUO Group, Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, 07122 Palma, Spain. francisca.serra@uib.es.
+ Serra, Francisca. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), 28029 Madrid, Spain. francisca.serra@uib.es.
+ Serra, Francisca. Institut d'Investigacio Sanitaria Illes Balears (IdISBa), 07120 Palma, Spain. francisca.serra@uib.es.
+MeSH Subject Headings
+ Adult
+ Anti-Inflammatory Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Docosahexaenoic Acids/pd [Pharmacology]
+ Eicosapentaenoic Acid/pd [Pharmacology]
+ Female
+ Gene Expression Regulation
+ Genetic Predisposition to Disease
+ Genotype
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/me [Metabolism]
+ Inflammation/pc [Prevention & Control]
+ Male
+ *Metabolic Syndrome/ge [Genetics]
+ *Obesity/ge [Genetics]
+ Odds Ratio
+ Risk Factors
+ Young Adult
+Keyword Heading
+ genetic score
+ low-grade inflammation
+ metabolic syndrome
+ obesity
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulating lipid metabolism and cytokine response is attenuated in overweight subjects and shows high inter-individual variability. This suggests that obesity may be exerting a synergistic effect with genetic background disturbing the anti-inflammatory potential of omega-3 long-chain polyunsaturated fatty acids (PUFA). In the present work, a genetic score aiming to explore the risk associated to low grade inflammation and obesity (LGI-Ob) has been elaborated and assessed as a tool to contribute to discern population at risk for metabolic syndrome. Pro-inflammatory gene expression and cytokine production as a response to omega-3 were associated with LGI-Ob score; and lower anti-inflammatory effect of PUFA was observed in subjects with a high genetic score. Furthermore, overweight/obese individuals showed positive correlation of both plasma C-Reactive Protein and triglyceride/HDLc-index with LGI-Ob; and high LGI-Ob score was associated with greater hypertension (p = 0.047), Type 2 diabetes (p = 0.026), and metabolic risk (p = 0.021). The study shows that genetic variation can influence inflammation and omega-3 response, and that the LGI-Ob score could be a useful tool to classify subjects at inflammatory risk and more prone to suffer metabolic syndrome and associated metabolic disturbances.
+Registry Number/Name of Substance
+ 0 (Anti-Inflammatory Agents). 0 (Biomarkers). 25167-62-8 (Docosahexaenoic Acids). AAN7QOV9EA (Eicosapentaenoic Acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11020298
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Galmes&issn=2072-6643&title=Nutrients&atitle=A+Genetic+Score+of+Predisposition+to+Low-Grade+Inflammation+Associated+with+Obesity+May+Contribute+to+Discern+Population+at+Risk+for+Metabolic+Syndrome.&volume=11&issue=2&spage=&epage=&date=2019&doi=10.3390%2Fnu11020298&pmid=30704070&sid=OVID:medline
+
+<1790>
+Unique Identifier
+ 30699099
+Title
+ Design of the Texas Hepatocellular Carcinoma Consortium Cohort Study.
+Source
+ American Journal of Gastroenterology. 114(3):530-532, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Feng Z; Marrero JA; Khaderi S; Singal AG; Kanwal F; Loo N; Beretta L; Ning J; El-Serag HB
+Authors Full Name
+ Feng, Ziding; Marrero, Jorge A; Khaderi, Saira; Singal, Amit G; Kanwal, Fasiha; Loo, Nicole; Beretta, Laura; Ning, Jing; El-Serag, Hashem B.
+Institution
+ Feng, Ziding. Department of Biostatistics, UT MD Anderson Cancer Center, Houston, Texas, USA.
+ Marrero, Jorge A. Division of Digestive and Liver Diseases, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
+ Khaderi, Saira. Division of Abdominal Transplantation, Baylor College of Medicine, Houston, Texas, USA.
+ Khaderi, Saira. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
+ Singal, Amit G. Division of Digestive and Liver Diseases, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
+ Kanwal, Fasiha. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
+ Loo, Nicole. Department of Medicine, Texas Liver Institute, San Antonio, Texas, USA.
+ Beretta, Laura. Department of Molecular and Cellular Oncology, UT MD Anderson Cancer Center, Houston, Texas, USA.
+ Ning, Jing. Department of Biostatistics, UT MD Anderson Cancer Center, Houston, Texas, USA.
+ El-Serag, Hashem B. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ *Carcinoma, Hepatocellular/di [Diagnosis]
+ Carcinoma, Hepatocellular/ep [Epidemiology]
+ Carcinoma, Hepatocellular/me [Metabolism]
+ Cohort Studies
+ Early Detection of Cancer
+ Germ-Line Mutation
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Inflammation/me [Metabolism]
+ *Liver Cirrhosis/dg [Diagnostic Imaging]
+ Liver Cirrhosis/ep [Epidemiology]
+ Liver Cirrhosis/me [Metabolism]
+ *Liver Neoplasms/di [Diagnosis]
+ Liver Neoplasms/ep [Epidemiology]
+ Liver Neoplasms/me [Metabolism]
+ Metabolic Syndrome/ep [Epidemiology]
+ Obesity/ep [Epidemiology]
+ Prospective Studies
+ Texas
+ Triglycerides/me [Metabolism]
+Abstract
+ OBJECTIVES: The Texas Hepatocellular Carcinoma Consortium cohort study investigates risk factors of hepatocellular carcinoma (HCC) and biomarkers for early HCC detection in patients with liver cirrhosis.
+
+ METHODS: Adult patients with liver cirrhosis are enrolled at 5 clinical centers from 3 cities in Texas, with a target of 5,000 patients. Clinical history, risk factor questionnaires, liver imaging, laboratory data, and blood samples were collected at enrollment and at each 6-month follow-up visit.
+
+ RESULTS: The primary outcome was the development of HCC. Biomarkers were tested in banked blood samples using prospective specimen collection, retrospective blinded evaluation design.
+
+ CONCLUSIONS: We describe study design, eligibility criteria, recruitment, study cores, and sample size and analysis considerations.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Triglycerides). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.14309%2fajg.0000000000000068
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Feng&issn=0002-9270&title=American+Journal+of+Gastroenterology&atitle=Design+of+the+Texas+Hepatocellular+Carcinoma+Consortium+Cohort+Study.&volume=114&issue=3&spage=530&epage=532&date=2019&doi=10.14309%2Fajg.0000000000000068&pmid=30699099&sid=OVID:medline
+
+<1791>
+Unique Identifier
+ 30688191
+Title
+ Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome.
+Source
+ Cardiology in the Young. 29(3):310-318, 2019 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aslan E; Sert A; Buyukinan M; Pirgon MO; Kurku H; Yilmaz H; Odabas D
+Authors Full Name
+ Aslan, Eyup; Sert, Ahmet; Buyukinan, Muammer; Pirgon, Mustafa Ozgur; Kurku, Huseyin; Yilmaz, Hakan; Odabas, Dursun.
+Institution
+ Aslan, Eyup. 1Department of Pediatric Cardiology,Denizli State Hospital,Denizli,Turkey.
+ Sert, Ahmet. 2Department of Pediatric Cardiology,Faculty of Medicine,Selcuk University,Konya,Turkey.
+ Buyukinan, Muammer. 3Department of Pediatric Endocrinology and Diabetes,University of Health Sciences,Konya Training and Research Hospital,Konya,Turkey.
+ Pirgon, Mustafa Ozgur. 4Department of Pediatric Endocrinology and Diabetes,Faculty of Medicine,Suleyman Demirel University,Isparta,Turkey.
+ Kurku, Huseyin. 5Department of Biochemistry,University of Health Sciences,Konya Training and Research Hospital,Konya,Turkey.
+ Yilmaz, Hakan. 6Department of Radiology,Agri State Hospital,Agri,Turkey.
+ Odabas, Dursun. 7Department of Pediatric Cardiology,Faculty of Medicine,Necmettin Erbakan University Konya,Konya,Turkey.
+MeSH Subject Headings
+ Adolescent
+ *Arginine/aa [Analogs & Derivatives]
+ Arginine/bl [Blood]
+ Biomarkers/bl [Blood]
+ Carotid Intima-Media Thickness
+ Child
+ Diastole
+ *Echocardiography, Doppler, Pulsed/mt [Methods]
+ Female
+ Follow-Up Studies
+ *Heart Ventricles/dg [Diagnostic Imaging]
+ Heart Ventricles/pp [Physiopathology]
+ Humans
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/pp [Physiopathology]
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Retrospective Studies
+ Systole
+ *Ventricular Function, Left/ph [Physiology]
+ *Ventricular Function, Right/ph [Physiology]
+ Ventricular Remodeling
+Keyword Heading
+ Adolescent
+ asymmetric dimethyl arginine
+ cardiovascular disease
+ carotid intima-media thickness
+ metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Purpose The aim of our study was to assess left ventricle and right ventricle systolic and diastolic functions in obese adolescents with metabolic syndrome using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotis intima-media thickness, and asymmetric dimethyl arginine levels.
+
+ METHODS: A total of 198 obese adolescents were enrolled in the study. The obese patients were divided into metabolic syndrome group and non-metabolic syndrome group. All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulsed, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness.
+
+ RESULTS: Obese adolescents were characterised by enlarged left end-diastolic, end-systolic and left atrial diameters, thicker left and right ventricular walls compared with non-obese adolescents. The metabolic syndrome group had normal left ventricle systolic function, impaired diastolic function, and altered global systolic and diastolic myocardial performance. In the metabolic syndrome obese group patients, left ventricle mass was found positively correlated with body mass index, waist and hip circumferences, diastolic blood pressure, age, and waist-to-hip circumference ratio. The carotid intima-media thickness was found positively correlated with waist and hip circumferences and total cholesterol levels. Asymmetric dimethyl arginine levels were found positively correlated with systolic blood pressure, waist-to-hip circumference ratio, and diastolic blood pressure.
+
+ CONCLUSIONS: The results of this study demonstrate that metabolic syndrome in adolescence is associated with significant changes in myocardial geometry and function. In addition, it has been associated with a high level of asymmetric dimethyl arginine concentration and thicker carotid intima-media thickness reflecting endothelial dysfunction.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (dimethylarginine). 94ZLA3W45F (Arginine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1017%2fS1047951118002329
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aslan&issn=1047-9511&title=Cardiology+in+the+Young&atitle=Left+and+right+ventricular+function+by+echocardiography%2C+tissue+Doppler+imaging%2C+carotid+intima-media+thickness%2C+and+asymmetric+dimethyl+arginine+levels+in+obese+adolescents+with+metabolic+syndrome.&volume=29&issue=3&spage=310&epage=318&date=2019&doi=10.1017%2FS1047951118002329&pmid=30688191&sid=OVID:medline
+
+<1792>
+Unique Identifier
+ 30678666
+Title
+ 11beta Hydroxysteroid dehydrogenase - 1 activity in type 2 diabetes mellitus: a comparative study.
+Source
+ BMC Endocrine Disorders. 19(1):15, 2019 Jan 24.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shukla R; Basu AK; Mandal B; Mukhopadhyay P; Maity A; Chakraborty S; Devrabhai PK
+Author NameID
+ Shukla, Ravindra; ORCID: http://orcid.org/0000-0002-5742-4096
+Authors Full Name
+ Shukla, Ravindra; Basu, Asish Kumar; Mandal, Biplab; Mukhopadhyay, Pradip; Maity, Animesh; Chakraborty, Satyam; Devrabhai, Praveen Kumar.
+Institution
+ Shukla, Ravindra. Department of Endocrinology & Metabolism, AIIMS, Jodhpur, 342005, India. ravindrashukla2@rediffmail.com.
+ Basu, Asish Kumar. Medical College Kolkata, Kolkata, India.
+ Mandal, Biplab. Medical College Kolkata, Kolkata, India.
+ Mukhopadhyay, Pradip. IPGMER, Kolkata, India.
+ Maity, Animesh. Medical College Kolkata, Kolkata, India.
+ Chakraborty, Satyam. Medical College Kolkata, Kolkata, India.
+ Devrabhai, Praveen Kumar. Medical College Kolkata, Kolkata, India.
+MeSH Subject Headings
+ *11-beta-Hydroxysteroid Dehydrogenases/me [Metabolism]
+ Adult
+ *Biomarkers/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/en [Enzymology]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Hydrocortisone/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity
+ Prognosis
+ Thinness
+Keyword Heading
+ 11 beta HSD 1
+ Cortisone acetate test
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: A comparative study of 11 beta HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted.
+
+ METHODS: A case control experimental study was performed enrolling thirty type 2 diabetes mellitus patients and thirty age, gender and BMI matched controls using cortisone acetate test.
+
+ RESULTS: The rise of serum cortisol after oral 25 mg cortisone acetate from baseline (dexamethasone suppressed level) is higher in subjects with type 2 diabetes and is associated with exercise, BMI, SGOT but not daily calorie intake, lipid parameters and thyroid status. Fasting blood glucose after overnight 1 mg oral dexamethasone is a strong predictor of 11HSD1 activity, irrespective of presence of type 2 diabetes.
+
+ CONCLUSION: 11beta HSD 1 activity is higher in type 2 diabetes mellitus subjects, especially those who are lean. Future 11 beta HSD 1 inhibitors targeting metabolic syndrome, will be most useful in those with increased fasting blood glucose. The role of DHEAS and vitamin D status needs to be explored.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 1-1-1-146 (11-beta-Hydroxysteroid Dehydrogenases). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0344-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shukla&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=11beta+Hydroxysteroid+dehydrogenase+-+1+activity+in+type+2+diabetes+mellitus%3A+a+comparative+study.&volume=19&issue=1&spage=15&epage=&date=2019&doi=10.1186%2Fs12902-019-0344-9&pmid=30678666&sid=OVID:medline
+
+<1793>
+Unique Identifier
+ 30674758
+Title
+ Association of Plasma Pentraxin-3 Level with Lipid Levels and Cardiovascular Risk Factors in People with No History of Lipid-Lowering Medication: the Dong-gu Study.
+Source
+ Journal of Atherosclerosis & Thrombosis. 26(8):738-745, 2019 Aug 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee R; Ahn HR; Shin MH; Kim HN; Lee YH; Choi SW; Kweon SS
+Authors Full Name
+ Lee, Ran; Ahn, Hye-Ran; Shin, Min-Ho; Kim, Hee-Nam; Lee, Young-Hoon; Choi, Seong-Woo; Kweon, Sun-Seog.
+Institution
+ Lee, Ran. Department of Preventive Medicine, Chonnam National University Medical School.
+ Ahn, Hye-Ran. Department of Nursing, Nambu University.
+ Shin, Min-Ho. Department of Preventive Medicine, Chonnam National University Medical School.
+ Kim, Hee-Nam. Department of Preventive Medicine, Chonnam National University Medical School.
+ Lee, Young-Hoon. Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine.
+ Choi, Seong-Woo. Department of Preventive Medicine, Chosun University Medical School.
+ Kweon, Sun-Seog. Department of Preventive Medicine, Chonnam National University Medical School.
+ Kweon, Sun-Seog. Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital.
+MeSH Subject Headings
+ Aged
+ *Biomarkers/bl [Blood]
+ *C-Reactive Protein/an [Analysis]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/et [Etiology]
+ Cholesterol, HDL/bl [Blood]
+ Cholesterol, LDL/bl [Blood]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/co [Complications]
+ Female
+ Follow-Up Studies
+ Humans
+ *Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/co [Complications]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Overweight/bl [Blood]
+ Overweight/co [Complications]
+ Prognosis
+ Prospective Studies
+ Risk Factors
+ *Serum Amyloid P-Component/an [Analysis]
+Keyword Heading
+ Atherosclerosis
+ Cardiovascular risk factor
+ Lipid
+ Pentraxin 3
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To elucidate the role of pentraxin-3 (PTX3) in atherosclerosis, we evaluated lipid and cardiovascular risk profiles according to the plasma PTX3 levels in subjects from the general population.
+
+ METHODS: A sub-cohort of 2,000 subjects was randomly sampled from a Korean community-based cohort study. After excluding those with a medication history for dyslipidemia, 1,747 subjects (902 men and 845 women) were included in the final analyses. Linear and logistic regressions with adjustment for appropriate variables were performed.
+
+ RESULTS: The PTX3 level was positively associated with the high-density lipoprotein cholesterol (HDL-C) level and negatively associated with the log-transformed triglyceride (TG) level, total cholesterol/HDL-C ratio, and low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio (p<0.05). Subjects with the highest PTX3 levels (>= 1.17 ng/dl) exhibited a lower risk of metabolic syndrome (odds ratio [OR] 0.73, 95% confidence interval [CI] 0.57-0.94), overweight/obesity (OR 0.65, 95% CI 0.50-0.83), increased TG level (OR 0.66, 95% CI 0.51-0.86), and increased HDL-C level (OR 0.67, 95% CI 0.51-0.88) compared to those with the lowest PTX3 level (<0.7 ng/dl).
+
+ CONCLUSION: The circulating PTX3 level was inversely associated with metabolic syndrome, overweight/obesity, and parameters of dyslipidemia, suggesting a cardioprotective role of PTX3 in atherosclerosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Lipids). 0 (Serum Amyloid P-Component). 148591-49-5 (PTX3 protein). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.5551%2fjat.47167
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=1340-3478&title=Journal+of+Atherosclerosis+%26+Thrombosis&atitle=Association+of+Plasma+Pentraxin-3+Level+with+Lipid+Levels+and+Cardiovascular+Risk+Factors+in+People+with+No+History+of+Lipid-Lowering+Medication%3A+the+Dong-gu+Study.&volume=26&issue=8&spage=738&epage=745&date=2019&doi=10.5551%2Fjat.47167&pmid=30674758&sid=OVID:medline
+
+<1794>
+Unique Identifier
+ 30672377
+Title
+ Body Composition and S-Klotho Plasma Levels in Middle-Aged Adults: A Cross-Sectional Study.
+Source
+ Rejuvenation Research. 22(6):478-483, 2019 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Amaro-Gahete FJ; De-la-O A; Jurado-Fasoli L; Espuch-Oliver A; de Haro T; Gutierrez A; Ruiz JR; Castillo MJ
+Authors Full Name
+ Amaro-Gahete, Francisco J; De-la-O, Alejandro; Jurado-Fasoli, Lucas; Espuch-Oliver, Andrea; de Haro, Tomas; Gutierrez, Angel; Ruiz, Jonatan R; Castillo, Manuel J.
+Institution
+ Amaro-Gahete, Francisco J. EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain.
+ Amaro-Gahete, Francisco J. PROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
+ De-la-O, Alejandro. EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain.
+ Jurado-Fasoli, Lucas. EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain.
+ Espuch-Oliver, Andrea. Clinical Laboratory Service, "Virgen de las Nieves" University Hospital, Granada, Spain.
+ de Haro, Tomas. Clinical Laboratory Service, "San Cecilio" University Hospital, Granada, Spain.
+ Gutierrez, Angel. EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain.
+ Ruiz, Jonatan R. PROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
+ Castillo, Manuel J. EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/bl [Blood]
+ *Body Composition
+ *Body Fat Distribution
+ *Body Mass Index
+ Body Weight
+ Bone Density
+ Cross-Sectional Studies
+ Female
+ *Glucuronidase/bl [Blood]
+ Humans
+ Klotho Proteins
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Sedentary Behavior
+ Thinness/bl [Blood]
+ *Thinness/di [Diagnosis]
+Keyword Heading
+ aging
+ bone mineral density
+ muscle
+ obesity
+ sarcopenia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The alpha-Klotho gene was identified as a possible "aging-suppressor" agent that extends life span when overexpressed. However, little is known about the association of the body composition with the secreted protein form of the alpha-Klotho gene (S-Klotho). Therefore, the aim of this study was to analyze the association of body composition, including lean and fat mass as well as bone mineral density (BMD), with S-Klotho plasma levels in middle-aged sedentary adults. A total of 74 (39 women) middle-aged sedentary adults (53.7 +/- 5.1 years old; 75.7 +/- 14.0 kg; 167.8 +/- 9.8 cm) participated in the study. We measured weight and height, and we used dual-energy X-ray absorptiometry to measure fat mass and lean mass. We calculated the body mass index (BMI), fat mass index (FMI), and lean mass index (LMI). The S-Klotho plasma levels were measured in the ethylenediaminetetraacetic acid plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. There was a strong positive association between LMI and S-Klotho plasma levels (beta = 74.794, R2 = 0.346, p < 0.001), which persisted after controlling for age and gender as well as after additionally controlling for FMI. Significantly positive associations of BMI and BMD were also found with S-Klotho plasma levels (beta = 33.981, R2 = 0.125, p = 0.002 and beta = 858.194, R2 = 0.058, p = 0.041, respectively), which disappeared after controlling for LMI (beta = 0.183, R2 = 0.611, p = 0.984 and beta = -379.426, R2 = 0.617, p = 0.290, respectively). FMI was not significantly associated with S-Klotho plasma levels. Our study shows that LMI is strongly associated with S-Klotho plasma levels and explains the associations of BMI and BMD with S-Klotho plasma levels in middle-aged sedentary adults.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-2-1-31 (Glucuronidase). EC 3-2-1-31 (Klotho Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1089%2frej.2018.2092
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Amaro-Gahete&issn=1549-1684&title=Rejuvenation+Research&atitle=Body+Composition+and+S-Klotho+Plasma+Levels+in+Middle-Aged+Adults%3A+A+Cross-Sectional+Study.&volume=22&issue=6&spage=478&epage=483&date=2019&doi=10.1089%2Frej.2018.2092&pmid=30672377&sid=OVID:medline
+
+<1795>
+Unique Identifier
+ 30662331
+Title
+ Ultrasound/Elastography techniques, lipidomic and blood markers compared to Magnetic Resonance Imaging in non-alcoholic fatty liver disease adults.
+Source
+ International Journal of Medical Sciences. 16(1):75-83, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cantero I; Elorz M; Abete I; Marin BA; Herrero JI; Monreal JI; Benito A; Quiroga J; Martinez A; Huarte MP; Uriz-Otano JI; Tur JA; Kearney J; Martinez JA; Zulet MA
+Authors Full Name
+ Cantero, Irene; Elorz, Mariana; Abete, Itziar; Marin, Bertha Araceli; Herrero, Jose Ignacio; Monreal, Jose Ignacio; Benito, Alberto; Quiroga, Jorge; Martinez, Ana; Huarte, M Pilar; Uriz-Otano, Juan Isidro; Tur, Josep Antoni; Kearney, John; Martinez, J Alfredo; Zulet, M Angeles.
+Institution
+ Cantero, Irene. Department of Nutrition, Food Science and Physiology. Centre for Nutrition Research. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
+ Elorz, Mariana. Department of Radiology, Clinica Universidad de Navarra, Pamplona, Spain.
+ Abete, Itziar. Department of Nutrition, Food Science and Physiology. Centre for Nutrition Research. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
+ Abete, Itziar. CIBERobn, Physiopathology of Obesity and Nutrition. Instituto de Salud Carlos III. Madrid, Spain.
+ Marin, Bertha Araceli. Department of Nutrition, Food Science and Physiology. Centre for Nutrition Research. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
+ Herrero, Jose Ignacio. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+ Herrero, Jose Ignacio. Liver Unit, Clinica Universidad de Navarra, Pamplona, Spain.
+ Herrero, Jose Ignacio. Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Madrid, Spain.
+ Monreal, Jose Ignacio. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+ Monreal, Jose Ignacio. Clinical Chemistry Department, Clinica Universidad de Navarra, Pamplona, Spain.
+ Benito, Alberto. Department of Radiology, Clinica Universidad de Navarra, Pamplona, Spain.
+ Quiroga, Jorge. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+ Quiroga, Jorge. Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Navarra, Spain.
+ Quiroga, Jorge. Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Madrid, Spain.
+ Martinez, Ana. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+ Martinez, Ana. Department of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain.
+ Huarte, M Pilar. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+ Huarte, M Pilar. Department of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain.
+ Uriz-Otano, Juan Isidro. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+ Uriz-Otano, Juan Isidro. Department of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain.
+ Tur, Josep Antoni. CIBERobn, Physiopathology of Obesity and Nutrition. Instituto de Salud Carlos III. Madrid, Spain.
+ Tur, Josep Antoni. Research Group on Community Nutrition and Oxidative Stress. University of Balearic Islands. Palma de Mallorca. Spain.
+ Kearney, John. School of Biological Sciences, Dublin Institute of Technology, Dublin, Republic of Ireland.
+ Martinez, J Alfredo. Department of Nutrition, Food Science and Physiology. Centre for Nutrition Research. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
+ Martinez, J Alfredo. CIBERobn, Physiopathology of Obesity and Nutrition. Instituto de Salud Carlos III. Madrid, Spain.
+ Martinez, J Alfredo. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+ Martinez, J Alfredo. IMDEA FOOD. Madrid.
+ Zulet, M Angeles. Department of Nutrition, Food Science and Physiology. Centre for Nutrition Research. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
+ Zulet, M Angeles. CIBERobn, Physiopathology of Obesity and Nutrition. Instituto de Salud Carlos III. Madrid, Spain.
+ Zulet, M Angeles. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Elasticity Imaging Techniques
+ Female
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Magnetic Resonance Imaging
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/dg [Diagnostic Imaging]
+ Ultrasonography
+Keyword Heading
+ FibroScan
+ MRI
+ NAFLD.
+ ROC
+ liver fat content
+ ultrasound
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) may progress to steatohepatitis, cirrhosis and complicated hepatocellular carcinoma with defined differential symptoms and manifestations.
+
+ OBJECTIVE: To evaluate the fatty liver status by several validated approaches and to compare imaging techniques, lipidomic and routine blood markers with magnetic resonance imaging in adults subjects with non-alcoholic fatty liver disease.
+
+ MATERIALS AND METHODS: A total of 127 overweight/obese with NAFLD, were parallelly assessed by Magnetic Resonance Imaging (MRI), ultrasonography, transient elastography and a validated metabolomic designed test to diagnose NAFLD in this cross-sectional study. Body composition (DXA), hepatic related biochemical measurements as well as the Fatty Liver Index (FLI) were evaluated. This study was registered as FLiO: Fatty Liver in Obesity study; NCT03183193.
+
+ RESULTS: The subjects with more severe liver disease were found to have worse metabolic parameters. Positive associations between MRI with inflammatory and insulin biomarkers were found. A linear regression model including ALT, RBP4 and HOMA-IR was able to explain 40.9% of the variability in fat content by MRI. In ROC analyses a combination panel formed of ALT, HOMA-IR and RBP4 followed by ultrasonography, ALT and metabolomic test showed the major predictive ability (77.3%, 74.6%, 74.3% and 71.1%, respectively) for liver fat content.
+
+ CONCLUSIONS: A panel combination including routine blood markers linked to insulin resistance showed highest associations with MRI considered as a gold standard for determining liver fat content. This combination of tests can facilitate the diagnosis of early stages of non-alcoholic liver disease thereby avoiding other invasive and expensive methods.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.7150%2fijms.28044
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cantero&issn=1449-1907&title=International+Journal+of+Medical+Sciences&atitle=Ultrasound%2FElastography+techniques%2C+lipidomic+and+blood+markers+compared+to+Magnetic+Resonance+Imaging+in+non-alcoholic+fatty+liver+disease+adults.&volume=16&issue=1&spage=75&epage=83&date=2019&doi=10.7150%2Fijms.28044&pmid=30662331&sid=OVID:medline
+
+<1796>
+Unique Identifier
+ 30658634
+Title
+ Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue.
+Source
+ Lipids in Health & Disease. 18(1):19, 2019 Jan 18.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tsai CC; Tiao MM; Sheen JM; Huang LT; Tain YL; Lin IC; Lin YJ; Lai YJ; Chen CC; Chang KA; Yu HR
+Author NameID
+ Yu, Hong-Ren; ORCID: http://orcid.org/0000-0003-1242-8760
+Authors Full Name
+ Tsai, Ching-Chou; Tiao, Mao-Meng; Sheen, Jiunn-Ming; Huang, Li-Tung; Tain, You-Lin; Lin, I-Chun; Lin, Yu-Ju; Lai, Yun-Ju; Chen, Chih-Cheng; Chang, Kow-Aung; Yu, Hong-Ren.
+Institution
+ Tsai, Ching-Chou. Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, 83301, Taiwan.
+ Tsai, Ching-Chou. Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
+ Tiao, Mao-Meng. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung, 83301, Taiwan, Republic of China.
+ Sheen, Jiunn-Ming. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung, 83301, Taiwan, Republic of China.
+ Huang, Li-Tung. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung, 83301, Taiwan, Republic of China.
+ Tain, You-Lin. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung, 83301, Taiwan, Republic of China.
+ Lin, I-Chun. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung, 83301, Taiwan, Republic of China.
+ Lin, Yu-Ju. Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, 83301, Taiwan.
+ Lai, Yun-Ju. Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, 83301, Taiwan.
+ Chen, Chih-Cheng. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung, 83301, Taiwan, Republic of China.
+ Chang, Kow-Aung. Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, 83301, Taiwan.
+ Yu, Hong-Ren. Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. yuu2004taiwan@yahoo.com.tw.
+ Yu, Hong-Ren. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung, 83301, Taiwan, Republic of China. yuu2004taiwan@yahoo.com.tw.
+MeSH Subject Headings
+ *Animal Nutritional Physiological Phenomena/ge [Genetics]
+ Animals
+ Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ Body Weight
+ *Circadian Clocks/ge [Genetics]
+ *Dexamethasone/ae [Adverse Effects]
+ *Diet, High-Fat
+ Female
+ Inflammation/ge [Genetics]
+ Inflammation/pa [Pathology]
+ Intra-Abdominal Fat/me [Metabolism]
+ *Intra-Abdominal Fat/pa [Pathology]
+ Leptin/me [Metabolism]
+ *Obesity/et [Etiology]
+ *Obesity/ge [Genetics]
+ Organ Size
+ Pregnancy
+ *Prenatal Exposure Delayed Effects/ge [Genetics]
+ Rats, Sprague-Dawley
+ Sirtuin 1/me [Metabolism]
+Keyword Heading
+ Adipose tissue
+ Circadian-clock
+ Nutrition sensory signals
+ Postnatal high-fat diet
+ Prenatal dexamethasone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Prenatal dexamethasone treatment has been shown to enhance the susceptibility of offspring to postnatal high-fat (HF) diet-induced programmed obesity. We investigated the metabolic phenotypes, nutrient-sensing signal and circadian-clock genes in adipose tissue that are programmed by prenatal dexamethasone exposure and postnatal HF diet.
+
+ METHODS: Male offspring of Sprague-Dawley rats were divided into four experimental groups: normal diet, prenatal dexamethasone exposure, postnatal HF diet, and prenatal dexamethasone plus postnatal HF diet. Postnatal HF diet was prescribed from weaning to 6 months of age.
+
+ RESULTS: Prenatal dexamethasone and postnatal HF diet exerted synergistic effects on body weight and visceral adiposity, whereas prenatal dexamethasone and postnatal HF diet altered the metabolic profile and caused leptin dysregulation. Prenatal dexamethasone and postnatal HF diet distinctly influenced nutrient-sensing molecules and circadian-clock genes in adipose tissue. The mRNA expression of mTOR, AMPK-alpha2, PPAR-alpha, and PPAR-gamma was suppressed by prenatal dexamethasone but enhanced by postnatal HF diet.
+
+ CONCLUSION: Prenatal dexamethasone and postnatal HF treatment cause dysregulation of nutrient-sensing molecules and circadian-clock genes in visceral adipose tissue. Characterizing altered nutrient-sensing molecules and circadian-clock genes has potential therapeutic relevance with respect to the pathogenesis and treatment of prenatal stress and postnatal HF diet-related metabolic disorders.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Leptin). 7S5I7G3JQL (Dexamethasone). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12944-019-0963-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tsai&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Obesity+programmed+by+prenatal+dexamethasone+and+postnatal+high-fat+diet+leads+to+distinct+alterations+in+nutrition+sensory+signals+and+circadian-clock+genes+in+visceral+adipose+tissue.&volume=18&issue=1&spage=19&epage=&date=2019&doi=10.1186%2Fs12944-019-0963-1&pmid=30658634&sid=OVID:medline
+
+<1797>
+Unique Identifier
+ 30653656
+Title
+ Newly identified set of obesity-related genotypes and abdominal fat influence the risk of insulin resistance in a Korean population.
+Source
+ Clinical Genetics. 95(4):488-495, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim M; Jeong S; Yoo HJ; An H; Jee SH; Lee JH
+Author NameID
+ Lee, Jong Ho; ORCID: https://orcid.org/0000-0002-2724-7295
+Authors Full Name
+ Kim, Minjoo; Jeong, Sarang; Yoo, Hye Jin; An, Hyoeun; Jee, Sun Ha; Lee, Jong Ho.
+Institution
+ Kim, Minjoo. Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, South Korea.
+ Kim, Minjoo. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomic, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea.
+ Jeong, Sarang. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomic, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea.
+ Yoo, Hye Jin. Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, South Korea.
+ Yoo, Hye Jin. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomic, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea.
+ An, Hyoeun. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomic, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea.
+ Jee, Sun Ha. Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea.
+ Lee, Jong Ho. Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, South Korea.
+ Lee, Jong Ho. National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomic, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea.
+MeSH Subject Headings
+ *Abdominal Fat
+ Alleles
+ Biomarkers
+ Female
+ *Genetic Predisposition to Disease
+ *Genotype
+ Humans
+ *Insulin Resistance/ge [Genetics]
+ Male
+ *Obesity/ep [Epidemiology]
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Odds Ratio
+ Polymorphism, Single Nucleotide
+ Public Health Surveillance
+ *Quantitative Trait Loci
+ Quantitative Trait, Heritable
+ Republic of Korea/ep [Epidemiology]
+ Retrospective Studies
+Keyword Heading
+ abdominal obesity
+ genetic risk score
+ genome-wide association study
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We aimed to identify obesity-related single-nucleotide polymorphism (SNP) loci in a Korean population and construct an obesity genetic risk score (GRS) to examine the association of the genetic predisposition to obesity with insulin resistance (IR). In total, 9675 subjects were included, and 7666 of these subjects were used for replication. A GRS was constructed using the SNP loci that overlapped in both cohort sets. The subjects showed a trend toward an increase in body mass index, waist circumference, systolic/diastolic blood pressure, homeostatic model assessment (HOMA)-IR, HOMA-B, and levels of insulin, triglyceride, and alanine aminotransferase across the tertiles of obesity GRS, while the adiponectin level showed a trend toward a decrease with increasing GRS. The associations between the obesity GRS and the measures of fasting insulin, HOMA-IR, and adiponectin were significant after adjusting for confounding factors. Moreover, a significant association between obesity GRS and HOMA-IR was observed in subjects with abdominal obesity. The present results indicate that a predisposition to obesity may affect IR in the Korean population and that abdominal fat may alter or modify the genetic effects. Furthermore, the set of obesity-related genotypes and abdominal fat may play interactive roles in determining the risk of IR. Copyright © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fcge.13509
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=0009-9163&title=Clinical+Genetics&atitle=Newly+identified+set+of+obesity-related+genotypes+and+abdominal+fat+influence+the+risk+of+insulin+resistance+in+a+Korean+population.&volume=95&issue=4&spage=488&epage=495&date=2019&doi=10.1111%2Fcge.13509&pmid=30653656&sid=OVID:medline
+
+<1798>
+Unique Identifier
+ 30646532
+Title
+ White Sweet Potato as Meal Replacement for Overweight White-Collar Workers: A Randomized Controlled Trial.
+Source
+ Nutrients. 11(1), 2019 Jan 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shih CK; Chen CM; Hsiao TJ; Liu CW; Li SC
+Author NameID
+ Shih, Chun-Kuang; ORCID: https://orcid.org/0000-0003-2545-911X
+ Li, Sing-Chung; ORCID: https://orcid.org/0000-0003-4244-7911
+Authors Full Name
+ Shih, Chun-Kuang; Chen, Chiao-Ming; Hsiao, Tun-Jen; Liu, Ching-Wen; Li, Sing-Chung.
+Institution
+ Shih, Chun-Kuang. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan. ckshih@tmu.edu.tw.
+ Chen, Chiao-Ming. Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, No. 70, Dazhi St., Zhongshan Dist, Taipei 10462, Taiwan. charming@g2.usc.edu.tw.
+ Hsiao, Tun-Jen. Chinese Taipei Society for the Study of Obesity, 250 Wu-Hsing Street, Taipei 11031, Taiwan. antifat53@gmail.com.
+ Liu, Ching-Wen. Department of Food Science, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Taichung 40704, Taiwan. stevenliu@thu.edu.tw.
+ Li, Sing-Chung. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan. sinchung@tmu.edu.tw.
+MeSH Subject Headings
+ Adult
+ Alanine Transaminase/bl [Blood]
+ Aspartate Aminotransferases/bl [Blood]
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Body Weight
+ Cholesterol/bl [Blood]
+ Creatinine/bl [Blood]
+ Diet
+ Female
+ Humans
+ *Ipomoea batatas/ch [Chemistry]
+ Male
+ *Meals
+ Middle Aged
+ Obesity/dh [Diet Therapy]
+ *Overweight/dh [Diet Therapy]
+ Triglycerides/bl [Blood]
+Keyword Heading
+ glycated hemoglobin
+ meal replacement
+ overweight
+ white sweet potato
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Overweight and obesity are a global concern. Meal replacements (MRs) are portion- and calorie-controlled meals, which make the food environment part of an individual's weight loss regimen. White sweet potato (WSP; Ipomoea batatas L.), used in traditional medicine in Brazil, Japan, and Taiwan, is a healthy carbohydrate source. In this randomized controlled trial, we assessed the effects of a WSP formula on body weight management in 58 white-collar workers through MR to elucidate the effects of this WSP-MR on factors leading to overweight. The participants consumed either two packs a day for a total of 132 g of WSP (WSP-MR group) or a normal diet daily (non-WSP group) for eight weeks. After eight weeks, body weight, body fat, body mass index, wrist circumference, thigh circumference, calf circumference, mid-arm circumference, and triceps skinfolds decreased significantly in both the groups. Moreover, the WSP-MR group demonstrated a 5% decrease in body weight, body fat, body mass index, and mid-arm circumference and a 3.5% decrease in glycated hemoglobin levels (p < 0.05). The treatment was well tolerated, without side effects or adverse events. Thus, our WSP formula as an MR can facilitate individual weight loss and thus has commercial application in the food industry.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides). 97C5T2UQ7J (Cholesterol). AYI8EX34EU (Creatinine). EC 2-6-1-1 (Aspartate Aminotransferases). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11010165
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shih&issn=2072-6643&title=Nutrients&atitle=White+Sweet+Potato+as+Meal+Replacement+for+Overweight+White-Collar+Workers%3A+A+Randomized+Controlled+Trial.&volume=11&issue=1&spage=&epage=&date=2019&doi=10.3390%2Fnu11010165&pmid=30646532&sid=OVID:medline
+
+<1799>
+Unique Identifier
+ 30642348
+Title
+ Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity.
+Source
+ Journal of Translational Medicine. 17(1):25, 2019 01 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Miao L; Yin RX; Pan SL; Yang S; Yang DZ; Lin WX
+Author NameID
+ Yin, Rui-Xing; ORCID: https://orcid.org/0000-0001-7883-4310
+Authors Full Name
+ Miao, Liu; Yin, Rui-Xing; Pan, Shang-Ling; Yang, Shuo; Yang, De-Zhai; Lin, Wei-Xiong.
+Institution
+ Miao, Liu. Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.
+ Yin, Rui-Xing. Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China. yinruixing@163.com.
+ Pan, Shang-Ling. Department of Pathophysiology, School of Premedical Science, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.
+ Yang, Shuo. Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.
+ Yang, De-Zhai. Department of Molecular Genetics, Medical Scientific Research Center, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.
+ Lin, Wei-Xiong. Department of Molecular Genetics, Medical Scientific Research Center, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.
+MeSH Subject Headings
+ 3' Untranslated Regions/ge [Genetics]
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Base Sequence
+ Biomarkers/bl [Blood]
+ *Circulating MicroRNA/bl [Blood]
+ *Circulating MicroRNA/ge [Genetics]
+ Cluster Analysis
+ Collagen Type I/ge [Genetics]
+ Collagen Type I, alpha 1 Chain
+ *Dyslipidemias/bl [Blood]
+ Dyslipidemias/co [Complications]
+ *Dyslipidemias/ge [Genetics]
+ Female
+ Gene Ontology
+ Gene Regulatory Networks
+ Humans
+ Male
+ Middle Aged
+ Molecular Sequence Annotation
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/ge [Genetics]
+ Polymorphism, Single Nucleotide/ge [Genetics]
+ Protein Interaction Maps/ge [Genetics]
+ ROC Curve
+ Young Adult
+Keyword Heading
+ COL1A1
+ Dyslipidemia
+ Gene Expression Omnibus
+ Obesity
+ Weighted gene co-expression network analysis
+ miR-3659
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The present study attempted to identify potential key genes and miRNAs of dyslipidemia in obese, and to investigate the possible mechanisms associated with them.
+
+ METHODS: The microarray data of GSE66676 were downloaded, including 67 obese samples from the Gene Expression Omnibus (GEO) database. The weighted gene co-expression network (WGCNA) analysis was performed using WGCNA package and grey60 module was considered as the highest correlation. Gene Ontology annotation and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses for this module were performed by clusterProfiler and DOSE package. A protein-protein interaction (PPI) network was established using Cytoscape software, and significant modules were analyzed using molecular complex detection.
+
+ RESULTS: Collagen type I alpha 1 chain gene (COL1A1) had the best significant meaning. After bioinformatic analysis, we identified four miRNAs (hsa-miR-3659, hsa-miR-4658, hsa-miR151a-5p and hsa-miR-151b) which can bind SNPs in 3'UTR in COL1A1. After validation with RT-qPCR, only two miRNAs (hsa-miR-3659 and hsa-miR151a-5p) had statistical significance.
+
+ CONCLUSIONS: The area of 0.806 for miR-3659 and 0.769 for miR-151a-5p under the ROC curve (AUC) may have good diagnostic value for dyslipidemia. Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity.
+Registry Number/Name of Substance
+ 0 (3' Untranslated Regions). 0 (Biomarkers). 0 (COL1A1 protein, human). 0 (Circulating MicroRNA). 0 (Collagen Type I). 0 (Collagen Type I, alpha 1 Chain).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12967-019-1776-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Miao&issn=1479-5876&title=Journal+of+Translational+Medicine&atitle=Circulating+miR-3659+may+be+a+potential+biomarker+of+dyslipidemia+in+patients+with+obesity.&volume=17&issue=1&spage=25&epage=&date=2019&doi=10.1186%2Fs12967-019-1776-8&pmid=30642348&sid=OVID:medline
+
+<1800>
+Unique Identifier
+ 30641941
+Title
+ SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet.
+Source
+ Nutrients. 11(1), 2019 Jan 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nguyen LT; Mak CH; Chen H; Zaky AA; Wong MG; Pollock CA; Saad S
+Author NameID
+ Nguyen, Long T; ORCID: https://orcid.org/0000-0002-0630-4959
+ Chen, Hui; ORCID: https://orcid.org/0000-0001-6883-3752
+Authors Full Name
+ Nguyen, Long T; Mak, Crystal H; Chen, Hui; Zaky, Amgad A; Wong, Muh G; Pollock, Carol A; Saad, Sonia.
+Institution
+ Nguyen, Long T. Renal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. long.t.nguyen@sydney.edu.au.
+ Mak, Crystal H. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia. Crystal.H.Mak@student.uts.edu.au.
+ Chen, Hui. Renal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. hui.chen-1@uts.edu.au.
+ Chen, Hui. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia. hui.chen-1@uts.edu.au.
+ Zaky, Amgad A. Renal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. amgadadolf@hotmail.com.
+ Wong, Muh G. Renal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. muhgeot.wong@sydney.edu.au.
+ Pollock, Carol A. Renal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. carol.pollock@sydney.edu.au.
+ Saad, Sonia. Renal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. sonia.saad@sydney.edu.au.
+ Saad, Sonia. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia. sonia.saad@sydney.edu.au.
+MeSH Subject Headings
+ Albuminuria/ur [Urine]
+ Animals
+ Biomarkers/ur [Urine]
+ Creatinine/ur [Urine]
+ Cyclooxygenase 2/ge [Genetics]
+ Cyclooxygenase 2/me [Metabolism]
+ *Diet, High-Fat
+ Female
+ Inflammation/ge [Genetics]
+ Inflammation/ur [Urine]
+ Kidney/me [Metabolism]
+ *Kidney Diseases/ge [Genetics]
+ Kidney Diseases/pc [Prevention & Control]
+ Male
+ Maternal Nutritional Physiological Phenomena
+ Mice
+ Mice, Inbred C57BL
+ Nitric Oxide Synthase Type II/ge [Genetics]
+ Nitric Oxide Synthase Type II/me [Metabolism]
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Organ Size
+ Oxidative Stress/ge [Genetics]
+ Postnatal Care
+ Pregnancy
+ Prenatal Exposure Delayed Effects/ge [Genetics]
+ Reactive Nitrogen Species/me [Metabolism]
+ Reactive Oxygen Species/me [Metabolism]
+ Sirtuin 1/ge [Genetics]
+ *Sirtuin 1/me [Metabolism]
+ Up-Regulation
+Keyword Heading
+ Obesity
+ chronic kidney disease
+ foetal programming
+ sirtuin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Maternal obesity has been associated with kidney disorders in male offspring. Our previous studies have demonstrated that Sirtuin (SIRT)1, an essential regulator of metabolic stress responses, is suppressed in the offspring as the result of maternal high-fat diet (HFD) consumption, which is likely to underpin the adverse metabolic and renal outcomes. To examine if SIRT1 overexpression or activation early in life can protect the offspring kidney, wild-type (WT) and transgenic (Tg) offspring were born to the same diet-induced obese female C57BL/6 mice through breeding with hemizygous SIRT1-transgenic (Tg) male mice and examined for renal pathological changes. In separate experiments, SIRT1 activator SRT1720 (25 mg/kg/2 days i.p) was administrated in WT offspring over 6 weeks of postnatal high-fat diet exposure. The results show that offspring born to obese dams have increased kidney weight, higher levels of renal triglycerides, and increased expression of oxidative stress, inflammatory, and fibrotic markers, as well as increased albuminuria compared to offspring of control dams. Both SIRT1 overexpression and SRT1720 treatment attenuated renal lipid contents and expression of lipogenesis, oxidative stress, and inflammatory markers; however, fibrosis was modestly reduced and albuminuria was not affected. The findings suggest that SIRT1 therapy can ameliorate some pathological mechanisms of kidney programming due to maternal obesity but may not be sufficient to prevent the resulting chronic kidney injury.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Reactive Nitrogen Species). 0 (Reactive Oxygen Species). AYI8EX34EU (Creatinine). EC 1-14-13-39 (Nitric Oxide Synthase Type II). EC 1-14-13-39 (Nos2 protein, mouse). EC 1-14-99 (Ptgs2 protein, mouse). EC 1-14-99-1 (Cyclooxygenase 2). EC 3-5-1 (Sirt1 protein, mouse). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11010146
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nguyen&issn=2072-6643&title=Nutrients&atitle=SIRT1+Attenuates+Kidney+Disorders+in+Male+Offspring+Due+to+Maternal+High-Fat+Diet.&volume=11&issue=1&spage=&epage=&date=2019&doi=10.3390%2Fnu11010146&pmid=30641941&sid=OVID:medline
+
+<1801>
+Unique Identifier
+ 30641777
+Title
+ Frequency of insulin resistance in nondiabetic adult Bangladeshi individuals of different obesity phenotypes.
+Source
+ Diabetes & Metabolic Syndrome. 13(1):62-67, 2019 Jan - Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sejooti SS; Naher S; Hoque MM; Zaman MS; Aminur Rashid HM
+Authors Full Name
+ Sejooti, Shabnam Sarwar; Naher, Sabikun; Hoque, Md Mozammel; Zaman, Mohammad Shiblee; Aminur Rashid, H M.
+Institution
+ Sejooti, Shabnam Sarwar. Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, 1000, Bangladesh. Electronic address: shabnamsejooti@gmail.com.
+ Naher, Sabikun. Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, 1000, Bangladesh.
+ Hoque, Md Mozammel. Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, 1000, Bangladesh.
+ Zaman, Mohammad Shiblee. Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, 1000, Bangladesh.
+ Aminur Rashid, H M. Department of Medicine, National Institute of Diseases of the Chest and Hospital (NIDCH), Dhaka, Bangladesh.
+MeSH Subject Headings
+ Adult
+ Bangladesh/ep [Epidemiology]
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ Male
+ Metabolic Syndrome/ep [Epidemiology]
+ *Metabolic Syndrome/et [Etiology]
+ Middle Aged
+ Obesity/cl [Classification]
+ *Obesity/co [Complications]
+ Phenotype
+ Prognosis
+ Young Adult
+Keyword Heading
+ Insulin resistance
+ Metabolic obesity
+ Metabolic syndrome
+ Nondiabetic adult
+ Obesity phenotypes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Insulin resistance (IR) is the corner stone of metabolic obesity. This cross-sectional analytical study was aimed to find out the frequency of IR in non-diabetic adult individuals of different obesity phenotypes that would help to implement preventive measures to avoid the cardiometabolic catastrophes.
+
+ METHODS: Total 955 nondiabetic adult individuals were selected and categorized into six metabolic phenotypes by metabolic syndrome criteria in each BMI group (18.5-24.9-normal weight, 25-29.9-overweight, >=30-obese). From them, metabolically obese normal weight, metabolically obese overweight, metabolically healthy obese and metabolically unhealthy obese were selected as Obesity phenotypes (N=616).
+
+ RESULTS: The frequency of IR was found to be very high (60.2%) in total nondiabetic adult obese individuals (N=616). Highest frequency of IR was found in MUO phenotype (76.3%), lowest frequency of IR was found in MONW phenotype (37.1%) and frequency of IR in MOOW and MHO phenotypes found to be identical but significantly (p<0.0001) less than MUO and significantly (p<0.0001) more than MONW phenotype. Among the obesity phenotypes, females were more insulin resistant than males (67.5% vs 48.1% respectively, p<0.05). Frequency of IR found significantly (p<0.05) more in female than male in all obesity phenotypes except in MUO phenotype where males found to show significantly (p<0.05) higher frequency than females. Frequency of IR was significantly higher in younger (20-39yrs) age group than 40-60yrs age group (63.2% vs 53.5% respectively, p<0.05).
+
+ CONCLUSION: IR is alarmingly high (60.2%) in nondiabetic adult obese individuals. Among different obesity phenotypes, it is highest (76.3%) in MUO and lowest (37.1%) in MONW. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.08.022
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sejooti&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Frequency+of+insulin+resistance+in+nondiabetic+adult+Bangladeshi+individuals+of+different+obesity+phenotypes.&volume=13&issue=1&spage=62&epage=67&date=2019&doi=10.1016%2Fj.dsx.2018.08.022&pmid=30641777&sid=OVID:medline
+
+<1802>
+Unique Identifier
+ 30641765
+Title
+ Blood pressure control, glycemic control, and dyslipidemia among healthy adults in the Cape Coast metropolis, Ghana.
+Source
+ Diabetes & Metabolic Syndrome. 13(1):56-61, 2019 Jan - Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gato WE; Acquah S; Nsiah P; Opoku ST; Apenteng BA; Johnson BK
+Authors Full Name
+ Gato, Worlanyo Eric; Acquah, Samuel; Nsiah, Paul; Opoku, Samuel Tawiah; Apenteng, Bettye Appiah; Johnson, Benjamin Kwasi.
+Institution
+ Gato, Worlanyo Eric. Department of Chemistry & Biochemistry, Georgia Southern University, Statesboro, GA, 30458, USA. Electronic address: wgato@georgiasouthern.edu.
+ Acquah, Samuel. Department of Medical Biochemistry, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
+ Nsiah, Paul. Department of Chemical Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
+ Opoku, Samuel Tawiah. Department of Health Policy & Management, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA, 30458, USA.
+ Apenteng, Bettye Appiah. Department of Health Policy & Management, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA, 30458, USA.
+ Johnson, Benjamin Kwasi. Department of Medical Biochemistry, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ *Blood Pressure
+ *Cardiovascular Diseases/ep [Epidemiology]
+ *Diabetes Mellitus/pp [Physiopathology]
+ *Dyslipidemias/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Ghana/ep [Epidemiology]
+ Humans
+ *Insulin Resistance
+ Male
+ *Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+Keyword Heading
+ Blood pressure
+ Cape coast
+ Cardiovascular disease
+ Dyslipidemia
+ Glycemia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The World Health Organization recommends the implementation of interventions focused on the early detection of clinical risk factors for cardiovascular disease (CVD) as effective strategies for the control of CVD in low resource settings. However, due to health system resource constraints, surveillance capacity for the identification of high-risk populations for non-communicable diseases, including CVD have been inadequate. The purpose of this study was to describe the prevalence of CVD clinical risk factors among healthy adults residing in the Cape Coast metropolis of Ghana. The clinical risk factors assessed included glycemic control, insulin sensitivity, lipid control and blood pressure.
+
+ METHODS: The study participants included 70 healthy adults without a previous diagnosis of CVD from Cape Coast metropolis. Blood samples, blood pressure and anthropometric measurement were obtained for each participant. Serum glycated hemoglobin (HbA1c), insulin, glucose, triglycerides, and cholesterol levels were measured.
+
+ RESULTS: Approximately four out of ten participants were either overweight or obese. Almost three-quarters of the sample were considered prehypertensive or hypertensive. About three in ten were clinically prediabetic. About a third of the participants had high non-HDL cholesterol levels. Triglyceride concentration levels were found to be high in almost 10 percent of the study sample. Approximately six percent were identified as having metabolic syndrome.
+
+ CONCLUSION: A significant proportion of the study participants were identified to be at risk for CVD. There is the need for adaptive and less resource-intensive CVD risk-factor screening interventions to allow for the timely detection and management of CVD risk factors in low-resource settings. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.08.020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gato&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Blood+pressure+control%2C+glycemic+control%2C+and+dyslipidemia+among+healthy+adults+in+the+Cape+Coast+metropolis%2C+Ghana.&volume=13&issue=1&spage=56&epage=61&date=2019&doi=10.1016%2Fj.dsx.2018.08.020&pmid=30641765&sid=OVID:medline
+
+<1803>
+Unique Identifier
+ 30641760
+Title
+ The association between resting metabolic rate and metabolic syndrome May Be mediated by adipokines in overweight and obese women.
+Source
+ Diabetes & Metabolic Syndrome. 13(1):530-534, 2019 Jan - Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sepandar F; Rashidbeygi E; Maghbooli Z; Khorrami-Nezhad L; Hajizadehoghaz M; Mirzaei K
+Authors Full Name
+ Sepandar, Farnaz; Rashidbeygi, Elaheh; Maghbooli, Zhila; Khorrami-Nezhad, Leila; Hajizadehoghaz, Masoomeh; Mirzaei, Khadijeh.
+Institution
+ Sepandar, Farnaz. Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Rashidbeygi, Elaheh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Maghbooli, Zhila. Multiple Sclerosis Research Center, Sina Hospital, Tehran University of Medical Sciences, Iran.
+ Khorrami-Nezhad, Leila. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
+ Hajizadehoghaz, Masoomeh. University of Nebraska-Lincoln, United States.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran. Electronic address: mirzaei_kh@tums.ac.ir.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adolescent
+ Adult
+ Aged
+ *Basal Metabolism/ph [Physiology]
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Overweight/bl [Blood]
+ *Overweight/di [Diagnosis]
+ Overweight/ep [Epidemiology]
+ Young Adult
+Keyword Heading
+ Adipokines
+ MetS
+ Obesity
+ RMR
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Adipokines play a major role in developing metabolic syndrome (MetS), and it has been found that there is a significant relationship between MetS and resting metabolic rate (RMR) in obese people. The present study aimed to investigate the mediatory effect of adipokines on the RMR-MetS relationship.
+
+ METHODS: This cross-sectional study included 263 obese and overweight women, mean BMI 33.28 (4.93) kg/m, and mean age 39.02 (11.60) who were assessed for RMR using indirect calorimetry. Moreover, using the body composition analyzer the Body composition was measured. Also, Enzyme-linked Immunosorbent Assay (ELISA) test provided a quantitative measurement of biochemical parameters.
+
+ RESULTS: The results indicated that women in low RMR group had higher fat mass (P<0.0001), FFM (P=0.002), weight (P=0.006), BMI (P<0.0001), age (P=0.01), and hs-CRP (P=0.001). The results did not confirm any significant mediating roles for RBP4 (P=0.051, beta=-0.28) and Vaspin (P=0.06, beta=0.32) in the RMR-MetS relationship. Additionally, after a binary regression test, Omentin-1 showed a significant mediating role (P=0.25, beta=0.04) as an interrelated agent to RMR and MetS.
+
+ CONCLUSION: As this study shows, Omentin-1 was found to play a significant mediating role as a mediatory agent in relationship between RMR and MetS. Copyright © 2018. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.10.012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sepandar&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=The+association+between+resting+metabolic+rate+and+metabolic+syndrome+May+Be+mediated+by+adipokines+in+overweight+and+obese+women.&volume=13&issue=1&spage=530&epage=534&date=2019&doi=10.1016%2Fj.dsx.2018.10.012&pmid=30641760&sid=OVID:medline
+
+<1804>
+Unique Identifier
+ 30641748
+Title
+ Anthropometric parameter that best predict metabolic syndrome in South west Nigeria.
+Source
+ Diabetes & Metabolic Syndrome. 13(1):48-54, 2019 Jan - Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adejumo EN; Adejumo AO; Azenabor A; Ekun AO; Enitan SS; Adebola OK; Ogundahunsi OA
+Authors Full Name
+ Adejumo, Esther Ngozi; Adejumo, Adedeji Olusola; Azenabor, Alfred; Ekun, Ayodele Oloruntoba; Enitan, Seyi Samson; Adebola, Olayimika Kehinde; Ogundahunsi, Omobolanle Abioye.
+Institution
+ Adejumo, Esther Ngozi. Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Ogun State, Nigeria. Electronic address: adejumoe@babcock.edu.ng.
+ Adejumo, Adedeji Olusola. Department of Community Health and Primary Health Care, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.
+ Azenabor, Alfred. Department of Medical Laboratory Science, University of Lagos, Lagos, Nigeria.
+ Ekun, Ayodele Oloruntoba. Department of Medical Laboratory Science, University of Lagos, Lagos, Nigeria.
+ Enitan, Seyi Samson. Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Ogun State, Nigeria.
+ Adebola, Olayimika Kehinde. Research, Innovation and International Cooperation Department, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
+ Ogundahunsi, Omobolanle Abioye. Department of Chemical Pathology, Olabisi Onabanjo University, Ogun State, Nigeria.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ *Anthropometry
+ *Biomarkers/an [Analysis]
+ Body Composition
+ Body Mass Index
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ Middle Aged
+ *Obesity/co [Complications]
+ Predictive Value of Tests
+ Risk Factors
+ Waist Circumference
+ Waist-Height Ratio
+ Waist-Hip Ratio
+Keyword Heading
+ Anthropometric parameters
+ Lagos
+ Metabolic syndrome
+ Nigeria
+ Predictors
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: This study compared the ability of anthropometric parameters to predict Metabolic Syndrome (MetS).
+
+ METHODS: Eleven anthropometric parameters: waist circumference (WC), body mass index (BMI), waist-to-height ratio (WHtR), a body shape index (ABSI), body roundness index (BRI), visceral adiposity index (VAI), abdominal volume index (AVI), Conicity Index (CI), body adiposity index (BAI), lipid accumulation product (LAP) and waist circumference-triglyceride index (WTI) were measured and calculated in apparently healthy subjects with and without MetS. A receiver operating characteristic (ROC) curve was applied to assess their ability to predict MetS.
+
+ RESULTS: Of the 535 subjects recruited 23% had MetS. WC had the largest area under the curve (AUC) in both men (0.814 95% CI 0.721-0.907) and women (0.819 95%CI 0.771-0.867). This did not differ from the AUC of BMI, WHtR, BRI, CI, BAI, LAP in men and BMI, WHtR, BAI, LAP, VAI and WTI in women (P>0.05). The cutoff point for WC was 89.5cm and 91.8cm in men and women respectively. The AUC of WC was the largest in the 40-49 and 60 years and above age groups while the AUC of LAP was the largest for age groups 30-39 and 50-59 years.
+
+ CONCLUSION: Of the 11 anthropometric parameters assessed, the WC was the best at predicting MetS in both men and women. There is need to ascertain the cutoff point and establish landmark for measuring WC especially for the sub Saharan region. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.08.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adejumo&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Anthropometric+parameter+that+best+predict+metabolic+syndrome+in+South+west+Nigeria.&volume=13&issue=1&spage=48&epage=54&date=2019&doi=10.1016%2Fj.dsx.2018.08.009&pmid=30641748&sid=OVID:medline
+
+<1805>
+Unique Identifier
+ 30641741
+Title
+ Relationship among obesity, blood lipids and insulin resistance in Bangladeshi adults.
+Source
+ Diabetes & Metabolic Syndrome. 13(1):444-449, 2019 Jan - Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Malik SUF; Mahmud Z; Alam J; Islam MS; Azad AK
+Authors Full Name
+ Malik, Syeda Umme Fahmida; Mahmud, Zabed; Alam, Jahangir; Islam, Mohammad Shahidul; Azad, Abul Kalam.
+Institution
+ Malik, Syeda Umme Fahmida. Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh; Department of Biochemistry, North East Medical College and Hospital, South Surma, Sylhet, Bangladesh. Electronic address: fahmidareza@yahoo.com.
+ Mahmud, Zabed. Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh. Electronic address: zabed@ualberta.ca.
+ Alam, Jahangir. Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh. Electronic address: jalambioru@yahoo.com.
+ Islam, Mohammad Shahidul. Department of Statistics, Shahjalal University of Science & Technology, Sylhet 3114, Bangladesh. Electronic address: shahed.stat@gmail.com.
+ Azad, Abul Kalam. Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh. Electronic address: dakazad-btc@sust.edu.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Bangladesh/ep [Epidemiology]
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Dyslipidemias/bl [Blood]
+ Dyslipidemias/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Prognosis
+ Young Adult
+Keyword Heading
+ Body mass index
+ Dyslipidemia
+ Insulin resistance
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Insulin resistance (IR) and abnormal lipid profiles are the risk factors for cardiovascular diseases in obesity. To clarify the relationship of the changes in insulin resistance, body weight and lipid profile, the present study was performed on Bangladeshi adults, total of 1500 individuals at the time of their general health examination in the hospital.
+
+ METHODS: After exclusion of other endocrine diseases, the remaining 772 patients were classified as IR>=2 and IR<2 based on the homeostatic model assessment-estimated insulin resistance (HOMA-IR) index. The endocrine disease free subjects were further clustered based on age, gender and obesity. The anthropometric and biochemical profiles were statistically analyzed and correlated with IR>=2 and IR<2 groups as well as other clusters of the subjects. Apart from some disparities, notable differences were observed in all anthropometric data.
+
+ RESULTS: Total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and serum insulin levels were significantly higher in IR>=2 group in comparison with IR<2 group. Obesity and dyslipidemia were associated as prevalent components of IR. Generalized linear model revealed that TC: LDL and TG: HDL had significant effect on IR. Age group II (41-60 years old) subjects had significantly higher lipid profile compared to age group I (20-40 years old) and age group III (61-80 years old).
+
+ CONCLUSIONS: Results reported herein support the notion that lipoprotein ratios might be the reliable biomarkers to evaluate IR. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.10.015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Malik&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Relationship+among+obesity%2C+blood+lipids+and+insulin+resistance+in+Bangladeshi+adults.&volume=13&issue=1&spage=444&epage=449&date=2019&doi=10.1016%2Fj.dsx.2018.10.015&pmid=30641741&sid=OVID:medline
+
+<1806>
+Unique Identifier
+ 30641739
+Title
+ Complement c1q tumor necrosis factor-related protein 3 a novel adipokine, protect against diabetes mellitus in young adult Egyptians.
+Source
+ Diabetes & Metabolic Syndrome. 13(1):434-438, 2019 Jan - Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elsaid HH; Elgohary MN; Elshabrawy AM
+Authors Full Name
+ Elsaid, Hanaa H; Elgohary, Marwan N; Elshabrawy, Arafa M.
+Institution
+ Elsaid, Hanaa H. Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
+ Elgohary, Marwan N. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
+ Elshabrawy, Arafa M. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Electronic address: arafashabrawy@ymail.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ *Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/et [Etiology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Male
+ *Obesity/co [Complications]
+ Prognosis
+ *Tumor Necrosis Factors/bl [Blood]
+ Young Adult
+Keyword Heading
+ C1q/TNF-related protein-3
+ Diabetes
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ C1q/TNF-related protein-3 (CTRP3) is a novel adipokine with anti-inflammatory and a multitude of biological effects on glucose and lipid metabolism however, the influence of CTRP3 on incidence of diabetes mellitus remain unclear. This study investigated the effects of CTRP3 levels in obese and normal body weight young adults on insulin resistance and occurrence of diabetes mellitus.
+
+ SUBJECTS AND METHODS: In this case control study, Serum levels of CTRP3, HbA1c, Lipid profile, glucose and insulin levels were determined in 75 obese and 68 normal body weight individuals.
+
+ RESULTS: In obese young adults CTRP3 concentrations were decreased compared to normal body weight young adults (NBW). The association between reduction of CTRP3 concentrations and the presence of diabetes is statistically significant. CTRP3 showed significant negative correlation with BMI, HOMA-IR and triglycerides as well as positive correlations with HDL - cholesterol while there is no association between CTRP3 and BMI within the NBW group. Higher HbA1C, HOMA-IR, and risk of diabetes development within obese subjects were related to lower CTRP3 concentration.
+
+ CONCLUSIONS: This study shows that reduction of CTRP3 concentrations is likely to bring a concomitant increase in risk of diabetes in obese and normal body weight young adults. Decrease in CTRP3 concentration may have an essential role in the pathophysiology of metabolic disorders concomitant to obesity. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (C1QTNF3 protein, human). 0 (Glycated Hemoglobin A). 0 (Tumor Necrosis Factors). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.10.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elsaid&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Complement+c1q+tumor+necrosis+factor-related+protein+3+a+novel+adipokine%2C+protect+against+diabetes+mellitus+in+young+adult+Egyptians.&volume=13&issue=1&spage=434&epage=438&date=2019&doi=10.1016%2Fj.dsx.2018.10.004&pmid=30641739&sid=OVID:medline
+
+<1807>
+Unique Identifier
+ 30641704
+Title
+ Adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer.
+Source
+ Diabetes & Metabolic Syndrome. 13(1):24-29, 2019 Jan - Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ghanem HB; Elsheikh M; El-Benhawy SA; Shahba A
+Authors Full Name
+ Ghanem, Heba Bassiony; Elsheikh, Mohammed; El-Benhawy, Sanaa Ali; Shahba, Abeer.
+Institution
+ Ghanem, Heba Bassiony. Medical Biochemistry Department, Faculty of Medicine, Tanta University, El-Geesh Street, Tanta, Egypt. Electronic address: ghanemhb@yahoo.com.
+ Elsheikh, Mohammed. General Surgery Department, Faculty of Medicine, Tanta University, El-Geesh Street, Tanta, Egypt.
+ El-Benhawy, Sanaa Ali. Radiation Sciences Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
+ Shahba, Abeer. Internal Medicine Department, Faculty of Medicine, Tanta University, El-Geesh Street, Tanta, Egypt.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ *Angiogenesis Modulating Agents/me [Metabolism]
+ *Biomarkers/an [Analysis]
+ Breast Neoplasms/bl [Blood]
+ *Breast Neoplasms/et [Etiology]
+ Breast Neoplasms/pa [Pathology]
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Egypt
+ *Epigenesis, Genetic
+ Fatty Acid-Binding Proteins/bl [Blood]
+ Female
+ Follow-Up Studies
+ Genomic Instability
+ Humans
+ *Inflammation Mediators/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Prognosis
+ Vascular Endothelial Growth Factor A/bl [Blood]
+Keyword Heading
+ 8-Hydroxy- 2'-deoxyguanosine
+ Fatty acid-binding proteins-4
+ Thioredoxin reductase
+ Tumor necrosis factor-alpha
+ Vascular endothelial growth factor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is the main determinant of type 2 diabetes. Some adipocytokines play important roles in diabetic complications. Lipid transport is an important aspect of lipid metabolism in cancer. Present study aimed to evaluate the effect of some adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer. Study Design was performed on eighty females divided into 20 healthy subjects (Group I), 20 patients with type 2 diabetes (Group II), 20 patients with breast cancer (Group III) & 20 patients with diabetes and breast cancer (Group IV). Demographic data & body mass index have been collected. Biochemical analysis included fasting & postprandial blood glucose, lipid profile, fatty acid-binding proteins-4 (FABP-4), tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor (VEGF), 8-hydroxy-2'-deoxyguanosine (8-OHdG) & thioredoxin reductase (TrxR) activity. Results revealed significant increase in FABP-4, TNF-alpha, VEGF, 8-OHdG and significant decreased TrxR activity in diabetic patients with breast cancer in comparison with other groups. These changes were evident in breast cancer subjects than diabetic and healthy cases and in diabetic than healthy cases. Conclusion : This study confirmed the role of FABP-4 in pathogenesis of type 2 diabetes & breast cancer via enhancing angiogenesis, inflammatory and epigenetic instability biomarkers. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Angiogenesis Modulating Agents). 0 (Biomarkers). 0 (FABP4 protein, human). 0 (Fatty Acid-Binding Proteins). 0 (Inflammation Mediators). 0 (VEGFA protein, human). 0 (Vascular Endothelial Growth Factor A).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.08.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ghanem&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Adipocytokines%2C+inflammatory%2C+epigenetic+instability+%26+angiogenesis+biomarkers+in+type+2+diabetic+Egyptian+women+with+breast+cancer.&volume=13&issue=1&spage=24&epage=29&date=2019&doi=10.1016%2Fj.dsx.2018.08.005&pmid=30641704&sid=OVID:medline
+
+<1808>
+Unique Identifier
+ 30641709
+Title
+ Increased waist circumference is associated with subclinical atherosclerosis in schoolchildren.
+Source
+ Diabetes & Metabolic Syndrome. 13(1):264-269, 2019 Jan - Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Domi H; Al-Shorman A
+Authors Full Name
+ Al-Domi, Hayder; Al-Shorman, Alaa.
+Institution
+ Al-Domi, Hayder. Department of Nutrition and Food Science, School of Agriculture, The University of Jordan, Amman, 11942, Jordan. Electronic address: h.aldomi@ju.edu.jo.
+ Al-Shorman, Alaa. Department of Nutrition and Food Science, School of Agriculture, The University of Jordan, Amman, 11942, Jordan. Electronic address: alaa.a.shorman@hotmail.com.
+MeSH Subject Headings
+ Adolescent
+ *Atherosclerosis/et [Etiology]
+ Atherosclerosis/pa [Pathology]
+ *Biomarkers/an [Analysis]
+ *Carotid Intima-Media Thickness
+ Child
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Inflammation Mediators/me [Metabolism]
+ Male
+ *Obesity/co [Complications]
+ Prognosis
+ *Waist Circumference
+Keyword Heading
+ Children and adolescents
+ Endothelial dysfunction
+ Inflammation
+ Subclinical atherosclerosis
+ Waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Waist circumference (WC) is an indicator of adiposity; particularly visceral fat, cardiometabolic risk factors and related morbidity. The aim of this study was to determine the attribution of WC to increased carotid intima-media thickness (cIMT) and circulating levels of inflammation and endothelial dysfunction in schoolchildren.
+
+ METHODS: A total of 122 children (61 boys and 61 girls) aged 10-15 years were distributed into three groups: (i) the lower smoothed sex- and age-specific WC (LWC) group (ii) the middle smoothed sex- and age-specific WC (MWC) group, and (iii) the higher smoothed sex- and age-specific WC (HWC) group. Measurements of cIMT using high-resolution B-mode ultrasound, lipemic profile, blood pressure, serum proinflammatory cytokines and soluble adhesion molecules were performed.
+
+ RESULTS: Mean measured values in the HWC and/or MWC groups showed significantly higher values (p<=0.05) of cIMT (mm), total cholesterol, triglycerides, low-density lipoprotein (LDL), blood pressure, interlukien-6 (IL-6), and interlukien-1 beta (IL-1beta), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1(ICAM-1) and E-selectin, and significantly lower values of high-density lipoprotein (HDL) as compared to the LWC group. Using multiple linear regression analysis of WC-SDS adjusted for BMI-SDS with the studied subclinical atherosclerosis risk, WC-SDS was significantly (p<=0.05) associated with the variation in HDL (R2=-0.12), LDL (R2=0.36), IL-6 (R2=0.26), and VCAM-1 (R2=0.26).
+
+ CONCLUSIONS: Higher WC is positively associated with atherosclerosis risk factors including increased cIMT, a state of dyslipidemia, higher blood pressure and circulating levels of inflammation and adhesion molecules among schoolchildren. Waist circumference seems to be useful for the prediction of subclinical atherosclerosis in schoolchildren. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.09.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Domi&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Increased+waist+circumference+is+associated+with+subclinical+atherosclerosis+in+schoolchildren.&volume=13&issue=1&spage=264&epage=269&date=2019&doi=10.1016%2Fj.dsx.2018.09.004&pmid=30641709&sid=OVID:medline
+
+<1809>
+Unique Identifier
+ 30637476
+Title
+ The Effects of Aging on Exhaled Nitric Oxide (FeNO) in a North African Population.
+Source
+ Lung. 197(1):73-80, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rouatbi S; Ghannouchi I; Bensaad H
+Author NameID
+ Rouatbi, Sonia; ORCID: https://orcid.org/0000-0003-3411-1182
+Authors Full Name
+ Rouatbi, Sonia; Ghannouchi, Ines; Bensaad, Helmi.
+Institution
+ Rouatbi, Sonia. Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, Tunisia. sonia.rouatbi@gmail.com.
+ Rouatbi, Sonia. Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, Street Mohamed Karoui, 4000, Sousse, Tunisia. sonia.rouatbi@gmail.com.
+ Rouatbi, Sonia. Heart Failure (LR12SP09) Research Laboratory, Farhat HACHED Hospital, Sousse, Tunisia. sonia.rouatbi@gmail.com.
+ Ghannouchi, Ines. Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, Tunisia.
+ Ghannouchi, Ines. Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, Street Mohamed Karoui, 4000, Sousse, Tunisia.
+ Bensaad, Helmi. Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, Tunisia.
+ Bensaad, Helmi. Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, Street Mohamed Karoui, 4000, Sousse, Tunisia.
+ Bensaad, Helmi. Heart Failure (LR12SP09) Research Laboratory, Farhat HACHED Hospital, Sousse, Tunisia.
+MeSH Subject Headings
+ Adolescent
+ Adolescent Development
+ Adult
+ Age Factors
+ Aged
+ Aged, 80 and over
+ Aging/eh [Ethnology]
+ *Aging/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Black People
+ Child
+ Child Development
+ Child, Preschool
+ Cross-Sectional Studies
+ *Exhalation
+ Female
+ Forced Expiratory Volume
+ Humans
+ Hypertension/eh [Ethnology]
+ Hypertension/me [Metabolism]
+ Hypertension/pp [Physiopathology]
+ *Lung/me [Metabolism]
+ Lung/pp [Physiopathology]
+ Male
+ Middle Aged
+ *Nitric Oxide/me [Metabolism]
+ Obesity/eh [Ethnology]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Tunisia
+ Vital Capacity
+ Young Adult
+Keyword Heading
+ Exhaled nitric oxide
+ Lung aging
+ Lung development
+ North Africa
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To determine and explain the effect of age on exhaled nitric oxide values in North African healthy subjects aged from 5 to 83 years.
+
+ DESIGN: Prospective cross-sectional study.
+
+ METHODS: Volunteer children adults and elderly healthy subjects were included. A medical questionnaire was used to assess several subject characteristics. The levels of exhaled fraction of nitric oxide (FeNO) were measured by Medisoft HypAir FeNO method. Spirometry function test was done after the FeNO measurement. The following parameters were measured: forced vital capacity (FVC, L); 1st second forced expiratory volume (FEV1, L); FEV1/FVC ratio (absolute value); maximal mid expiratory flow (MMEF, L/s); Mid expiratory flow from 25 to 75% (MEF25%, MEF50%, and MEF75%). Statistical analyses were carried out using Statistica software with a significance set at the 0.05 level.
+
+ RESULTS: A significant increase in FeNO is noted between groups with respective age ranges of (5, 17) and (17, 25) years with a breakpoint at 1,397,034 years. A significant decrease of FeNO is noted between groups with respective age ranges of (45, 55) and (55, 65) years with a breakpoint at 6,366,052 years. No statistical significant difference was found between females' and males' means FeNO data. Finally, SEL, obesity status, and hypertension contribute significantly in the variations of FeNO values.
+
+ CONCLUSION: The development and aging of the lung touched non-respiratory functions and so modified FeNO values in healthy North African subjects.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 31C4KY9ESH (Nitric Oxide).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00408-018-0188-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rouatbi&issn=0341-2040&title=Lung&atitle=The+Effects+of+Aging+on+Exhaled+Nitric+Oxide+%28FeNO%29+in+a+North+African+Population.&volume=197&issue=1&spage=73&epage=80&date=2019&doi=10.1007%2Fs00408-018-0188-5&pmid=30637476&sid=OVID:medline
+
+<1810>
+Unique Identifier
+ 30636483
+Title
+ Association of Body Mass Index With Risk Factor Optimization and Guideline-Directed Medical Therapy in US Veterans With Cardiovascular Disease.
+Source
+ Circulation. Cardiovascular Quality & Outcomes. 12(1):e004817, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hira RS; Kataruka A; Akeroyd JM; Ramsey DJ; Pokharel Y; Gurm HS; Nasir K; Deswal A; Jneid H; Alam M; Ballantyne CM; Petersen LA; Virani SS
+Authors Full Name
+ Hira, Ravi S; Kataruka, Akash; Akeroyd, Julia M; Ramsey, David J; Pokharel, Yashashwi; Gurm, Hitinder S; Nasir, Khurram; Deswal, Anita; Jneid, Hani; Alam, Mahboob; Ballantyne, Christie M; Petersen, Laura A; Virani, Salim S.
+Institution
+ Hira, Ravi S. University of Washington, Seattle (R.S.H., A.K.).
+ Kataruka, Akash. University of Washington, Seattle (R.S.H., A.K.).
+ Akeroyd, Julia M. Health Policy, Quality and Informatics Program, Michael E. DeBakey Veteran Affairs Medical Center Health Services Research and Development Center for Innovations, Houston, TX (J.M.A., L.A.P., S.S.V.).
+ Ramsey, David J. Section of Health Services Research, Department of Medicine (D.J.R., L.A.P., S.S.V.), Baylor College of Medicine, Houston, TX.
+ Pokharel, Yashashwi. Section of Cardiovascular Research, Department of Medicine, Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City (Y.P.).
+ Gurm, Hitinder S. University of Michigan, Ann Arbor (H.S.G.).
+ Nasir, Khurram. Baptist Health South Florida, Miami (K.N.).
+ Deswal, Anita. Michael E. DeBakey VA Medical Center, Houston, TX (A.D., H.J., L.A.P., S.S.V.).
+ Deswal, Anita. Baylor College of Medicine, Houston, TX (A.D., H.J., M.A., C.M.B., L.A.P., S.S.V.).
+ Jneid, Hani. Michael E. DeBakey VA Medical Center, Houston, TX (A.D., H.J., L.A.P., S.S.V.).
+ Jneid, Hani. Baylor College of Medicine, Houston, TX (A.D., H.J., M.A., C.M.B., L.A.P., S.S.V.).
+ Alam, Mahboob. Baylor College of Medicine, Houston, TX (A.D., H.J., M.A., C.M.B., L.A.P., S.S.V.).
+ Ballantyne, Christie M. Section of Cardiovascular Research, Department of Medicine (C.M.B.), Baylor College of Medicine, Houston, TX.
+ Ballantyne, Christie M. Baylor College of Medicine, Houston, TX (A.D., H.J., M.A., C.M.B., L.A.P., S.S.V.).
+ Ballantyne, Christie M. Center for Cardiovascular Prevention, Methodist DeBakey Heart and Vascular Center, Houston, TX (C.M.B.).
+ Petersen, Laura A. Health Policy, Quality and Informatics Program, Michael E. DeBakey Veteran Affairs Medical Center Health Services Research and Development Center for Innovations, Houston, TX (J.M.A., L.A.P., S.S.V.).
+ Petersen, Laura A. Section of Health Services Research, Department of Medicine (D.J.R., L.A.P., S.S.V.), Baylor College of Medicine, Houston, TX.
+ Petersen, Laura A. Michael E. DeBakey VA Medical Center, Houston, TX (A.D., H.J., L.A.P., S.S.V.).
+ Petersen, Laura A. Baylor College of Medicine, Houston, TX (A.D., H.J., M.A., C.M.B., L.A.P., S.S.V.).
+ Virani, Salim S. Health Policy, Quality and Informatics Program, Michael E. DeBakey Veteran Affairs Medical Center Health Services Research and Development Center for Innovations, Houston, TX (J.M.A., L.A.P., S.S.V.).
+ Virani, Salim S. Section of Health Services Research, Department of Medicine (D.J.R., L.A.P., S.S.V.), Baylor College of Medicine, Houston, TX.
+ Virani, Salim S. Michael E. DeBakey VA Medical Center, Houston, TX (A.D., H.J., L.A.P., S.S.V.).
+ Virani, Salim S. Baylor College of Medicine, Houston, TX (A.D., H.J., M.A., C.M.B., L.A.P., S.S.V.).
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Blood Pressure
+ *Body Mass Index
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/dt [Drug Therapy]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/dt [Drug Therapy]
+ Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Hydroxymethylglutaryl-CoA Reductase Inhibitors/ae [Adverse Effects]
+ *Hydroxymethylglutaryl-CoA Reductase Inhibitors/tu [Therapeutic Use]
+ Hypertension/di [Diagnosis]
+ Hypertension/dt [Drug Therapy]
+ Hypertension/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Obesity/ep [Epidemiology]
+ Platelet Aggregation Inhibitors/ae [Adverse Effects]
+ *Platelet Aggregation Inhibitors/tu [Therapeutic Use]
+ Risk Assessment
+ Risk Factors
+ *Secondary Prevention/mt [Methods]
+ Thinness/di [Diagnosis]
+ *Thinness/dt [Drug Therapy]
+ Thinness/ep [Epidemiology]
+ Time Factors
+ Treatment Outcome
+ United States/ep [Epidemiology]
+ *Veterans Health
+Keyword Heading
+ body mass index
+ diabetes mellitus
+ hypertension
+ obesity
+ secondary prevention
+ statin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a growing epidemic that has been linked to the development of cardiovascular disease (CVD). Guideline-directed medications for secondary prevention and risk factor control are recommended for patients with all forms of CVD. The association of body mass index (BMI) with use of medications for secondary prevention and risk factor control in patients with CVD are poorly understood.
+
+ METHODS AND RESULTS: We identified 1 122 567 patients with CVD receiving care in 130 Veterans Affairs facilities from October 1, 2013, to September 30, 2014. Five groups were stratified by BMI-underweight (BMI, <18.5 kg/m2), normal (BMI, 18.5-24.9 kg/m2), overweight (BMI, 25-29.9 kg/m2), obese (BMI, 30-39.9 kg/m2), and extremely obese (BMI, >=40 kg/m2). A composite of 4 measures-blood pressure <140/90 mm Hg, hemoglobin A1c <=9% in diabetic patients, statin use, and antiplatelet use-termed optimal medial therapy (OMT) was compared among groups. Multivariable logistic regression was performed with normal BMI as the referent category. Underweight patients comprised 12 623 (1.1%), normal BMI 230 471 (20.5%), overweight 413 590 (36.8%), obese 404 105 (36%), and extremely obese 61 778 (5.5%) of the cohort. Only 43.7% of the entire cohort received OMT, and this was the highest in the overweight group. Adjusted odds ratios for receiving OMT were 0.81 (95% CI, 0.77-0.85), 1.11 (95% CI, 1.10-1.13), 1.08 (95% CI, 1.06-1.09), and 0.87 (95% CI, 0.85-0.89), for patients who were underweight, overweight, obese, and extremely obese, respectively, compared with normal BMI.
+
+ CONCLUSIONS: OMT was low in the entire cohort. There is an inverse U-shaped relationship between OMT and BMI with patients who are underweight and extremely obese less likely to receive OMT compared with patients with normal BMI.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors). 0 (Platelet Aggregation Inhibitors). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Comparative Study. Journal Article. Observational Study. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1161%2fCIRCOUTCOMES.118.004817
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hira&issn=1941-7713&title=Circulation.+Cardiovascular+Quality+%26+Outcomes&atitle=Association+of+Body+Mass+Index+With+Risk+Factor+Optimization+and+Guideline-Directed+Medical+Therapy+in+US+Veterans+With+Cardiovascular+Disease.&volume=12&issue=1&spage=e004817&epage=&date=2019&doi=10.1161%2FCIRCOUTCOMES.118.004817&pmid=30636483&sid=OVID:medline
+
+<1811>
+Unique Identifier
+ 30635961
+Title
+ High-intensity breastfeeding improves insulin sensitivity during early post-partum period in obese women with gestational diabetes.
+Source
+ Diabetes/Metabolism Research Reviews. 35(4):e3127, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yasuhi I; Yamashita H; Maeda K; Nomiyama M; Mizunoe T; Tada K; Yorozu M; Ogawa M; Kodama T; Yamaguchi K; Okura N; Kawakami K; Maekawa Y; Hayashi K
+Author NameID
+ Yasuhi, Ichiro; ORCID: https://orcid.org/0000-0001-7129-9175
+Authors Full Name
+ Yasuhi, Ichiro; Yamashita, Hiroshi; Maeda, Kazuhisa; Nomiyama, Makoto; Mizunoe, Tomoya; Tada, Katsuhiko; Yorozu, Moe; Ogawa, Masanobu; Kodama, Takashi; Yamaguchi, Ken; Okura, Naofumi; Kawakami, Kosuke; Maekawa, Yuka; Hayashi, Kimikazu.
+Institution
+ Yasuhi, Ichiro. Department of Obstetrics and Gynecology, National Hospital Organization Nagasaki Medical Center, Omura, Japan.
+ Yamashita, Hiroshi. Department of Obstetrics and Gynecology, National Hospital Organization Nagasaki Medical Center, Omura, Japan.
+ Maeda, Kazuhisa. Department of Obstetrics and Gynecology, Shikoku Medical Center for Children and Adults, Zentsuji, Japan.
+ Nomiyama, Makoto. Department of Obstetrics and Gynecology, Saga Hospital, Saga, Japan.
+ Mizunoe, Tomoya. Department of Obstetrics and Gynecology, Kure Medical Center, Kure, Japan.
+ Tada, Katsuhiko. Department of Obstetrics and Gynecology, Okayama Medical Center, Okayama, Japan.
+ Yorozu, Moe. Department of Obstetrics and Gynecology, Okayama Medical Center, Okayama, Japan.
+ Ogawa, Masanobu. Department of Obstetrics and Gynecology, Kyusyu Medical Center, Fukuoka, Japan.
+ Kodama, Takashi. Department of Obstetrics and Gynecology, Higashihiroshima Medical Center, Higashihiroshima, Japan.
+ Yamaguchi, Ken. Department of Obstetrics and Gynecology, Kyoto Medical Center, Kyoto, Japan.
+ Okura, Naofumi. Department of Obstetrics and Gynecology, Kokura Medical Center, Kitakyushu, Japan.
+ Kawakami, Kosuke. Department of Obstetrics and Gynecology, Kokura Medical Center, Kitakyushu, Japan.
+ Maekawa, Yuka. Department of Obstetrics and Gynecology, Mie Chuo Medical Center, Tsu, Japan.
+ Hayashi, Kimikazu. Department of Obstetrics and Gynecology, Kanmon Medical Center, Shimonoseki, Japan.
+MeSH Subject Headings
+ Adult
+ Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Breast Feeding/sn [Statistics & Numerical Data]
+ *Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ *Diabetes, Gestational/rh [Rehabilitation]
+ Female
+ Follow-Up Studies
+ *Glucose Intolerance/pc [Prevention & Control]
+ Glucose Tolerance Test
+ Homeostasis
+ Humans
+ *Insulin Resistance
+ Male
+ Obesity/pp [Physiopathology]
+ Postpartum Period
+ Pregnancy
+ Prognosis
+ Prospective Studies
+ Weight Loss
+Keyword Heading
+ breastfeeding
+ gestational diabetes mellitus
+ homeostatic model assessment insulin resistance (HOMA-IR)
+ insulin resistance
+ post-partum weight change
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: To investigate whether high-intensity breastfeeding (HIB) reduces insulin resistance during early post-partum period in women with gestational diabetes (GDM), independent of post-partum weight change (PWC).
+
+ MATERIALS AND METHODS: In this multicentre prospective study, we included Japanese women with GDM who underwent a 75-g oral glucose tolerance test (OGTT) during early post-partum. We measured plasma insulin during OGTT to obtain a homeostasis model of assessment of insulin resistance (HOMA-IR). We defined the condition in which infants were fed by breastfeeding alone or greater than or equal to 80% of the volume as HIB, and other statuses, including partial and nonbreastfeeding, as non-HIB. We investigated the association between post-partum HOMA-IR and the breastfeeding status after adjusting for confounders including PWC.
+
+ RESULTS: Among 222 women with GDM who underwent the OGTT at 7.9 +/- 2.3 weeks post-partum with a PWC of -7.8 +/- 3.4 kg, although the rate of abnormal glucose tolerance (prediabetes and diabetes) did not differ between the groups (33% vs 32%), the HOMA-IR in the HIB women (n = 166) was significantly lower than that in the non-HIB women (n = 56) (1.12 +/- 0.85 vs 1.72 +/- 1.43, P = 0.0002). The effect of the HIB was independently associated with lower HOMA-IR after adjusting for confounders including PMC. However, the subgroup analysis according to their pre-pregnancy obesity states showed that the effect was seen only in the obese subjects (BMI >= 25).
+
+ CONCLUSIONS: In obese Japanese women with GDM, HIB has a significant effect in reducing insulin resistance during early post-partum, independent of the post-partum weight loss. Copyright © 2019 John Wiley & Sons, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Multicenter Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fdmrr.3127
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yasuhi&issn=1520-7552&title=Diabetes%2FMetabolism+Research+Reviews&atitle=High-intensity+breastfeeding+improves+insulin+sensitivity+during+early+post-partum+period+in+obese+women+with+gestational+diabetes.&volume=35&issue=4&spage=e3127&epage=&date=2019&doi=10.1002%2Fdmrr.3127&pmid=30635961&sid=OVID:medline
+
+<1812>
+Unique Identifier
+ 30635861
+Title
+ Diet-induced obesity causes hypothalamic neurochemistry alterations in Swiss mice.
+Source
+ Metabolic Brain Disease. 34(2):565-573, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ de Bona Schraiber R; de Mello AH; Garcez ML; de Bem Silveira G; Zacaron RP; de Souza Goldim MP; Budni J; Silveira PCL; Petronilho F; Ferreira GK; Rezin GT
+Authors Full Name
+ de Bona Schraiber, Rosiane; de Mello, Aline Haas; Garcez, Michelle Lima; de Bem Silveira, Gustavo; Zacaron, Rubya Pereira; de Souza Goldim, Mariana Pereira; Budni, Josiane; Silveira, Paulo Cesar Lock; Petronilho, Fabricia; Ferreira, Gabriela Kozuchovski; Rezin, Gislaine Tezza.
+Institution
+ de Bona Schraiber, Rosiane. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade do Sul de Santa Catarina, Tubarao, SC, Brazil.
+ de Mello, Aline Haas. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade do Sul de Santa Catarina, Tubarao, SC, Brazil.
+ Garcez, Michelle Lima. Neuroscience Laboratory, Unit Neurodegeneration, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil.
+ de Bem Silveira, Gustavo. Laboratory of Physiology and Biochemistry of Exercise, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil.
+ Zacaron, Rubya Pereira. Laboratory of Physiology and Biochemistry of Exercise, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil.
+ de Souza Goldim, Mariana Pereira. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade do Sul de Santa Catarina, Tubarao, SC, Brazil.
+ Budni, Josiane. Neuroscience Laboratory, Unit Neurodegeneration, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil.
+ Silveira, Paulo Cesar Lock. Laboratory of Physiology and Biochemistry of Exercise, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil.
+ Petronilho, Fabricia. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade do Sul de Santa Catarina, Tubarao, SC, Brazil.
+ Ferreira, Gabriela Kozuchovski. UNISOCIESC, R. Albano Schmidt, 3333 - Boa Vista, Joinville, SC, 89206-001, Brazil. gabikozuco@hotmail.com.
+ Rezin, Gislaine Tezza. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Universidade do Sul de Santa Catarina, Tubarao, SC, Brazil.
+MeSH Subject Headings
+ Animals
+ Antioxidants/pd [Pharmacology]
+ Biomarkers/me [Metabolism]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Energy Intake/de [Drug Effects]
+ *Energy Metabolism/ph [Physiology]
+ *Hypothalamus/me [Metabolism]
+ Inflammation/me [Metabolism]
+ Male
+ Mice
+ Neurochemistry/mt [Methods]
+ *Obesity/me [Metabolism]
+ Oxidative Stress/de [Drug Effects]
+Keyword Heading
+ Energy metabolism
+ Hypothalamus
+ Inflammation
+ Obesity
+ Oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The aim of this study was to assess inflammatory parameters, oxidative stress and energy metabolism in the hypothalamus of diet-induced obese mice. Male Swiss mice were divided into two study groups: control group and obese group. The animals in the control group were fed a diet with adequate amounts of macronutrients (normal-lipid diet), whereas the animals in the obese group were fed a high-fat diet to induce obesity. Obesity induction lasted 10 weeks, at the end of this period the disease model was validated in animals. The animals in the obese group had higher calorie consumption, higher body weight and higher weight of mesenteric fat compared to control group. Obesity showed an increase in levels of interleukin 1beta and decreased levels of interleukin 10 in the hypothalamus. Furthermore, increased lipid peroxidation and protein carbonylation, and decreased level of glutathione in the hypothalamus of obese animals. However, there was no statistically significant difference in the activity of antioxidant enzymes, superoxide dismutase and catalase. The obese group had lower activity of complex I, II and IV of the mitochondrial respiratory chain, as well as lower activity of creatine kinase in the hypothalamus as compared to the control group. Thus, the results from this study showed changes in inflammatory markers, and dysregulation of metabolic enzymes in the pathophysiology of obesity.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11011-018-0337-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=de+Bona+Schraiber&issn=0885-7490&title=Metabolic+Brain+Disease&atitle=Diet-induced+obesity+causes+hypothalamic+neurochemistry+alterations+in+Swiss+mice.&volume=34&issue=2&spage=565&epage=573&date=2019&doi=10.1007%2Fs11011-018-0337-9&pmid=30635861&sid=OVID:medline
+
+<1813>
+Unique Identifier
+ 30634478
+Title
+ Non-Cholesterol Sterol Concentrations as Biomarkers for Cholesterol Absorption and Synthesis in Different Metabolic Disorders: A Systematic Review.
+Source
+ Nutrients. 11(1), 2019 Jan 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mashnafi S; Plat J; Mensink RP; Baumgartner S
+Authors Full Name
+ Mashnafi, Sultan; Plat, Jogchum; Mensink, Ronald P; Baumgartner, Sabine.
+Institution
+ Mashnafi, Sultan. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands. s.mashnafi@maastrichtuniversity.nl.
+ Plat, Jogchum. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands. j.plat@maastrichtuniversity.nl.
+ Mensink, Ronald P. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands. r.mensink@maastrichtuniversity.nl.
+ Baumgartner, Sabine. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands. sabine.baumgartner@maastrichtuniversity.nl.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ Cardiovascular Diseases/bl [Blood]
+ Cholesterol/aa [Analogs & Derivatives]
+ Cholesterol/bl [Blood]
+ *Cholesterol/me [Metabolism]
+ Desmosterol/bl [Blood]
+ Diabetes Mellitus/bl [Blood]
+ Humans
+ Intestinal Absorption
+ Intestinal Diseases/bl [Blood]
+ Kidney Diseases/bl [Blood]
+ Liver Diseases/bl [Blood]
+ *Metabolic Diseases/bl [Blood]
+ Obesity/bl [Blood]
+ Overweight/bl [Blood]
+ Phytosterols/bl [Blood]
+ Sitosterols/bl [Blood]
+ *Sterols/bl [Blood]
+Keyword Heading
+ BMI
+ cardiovascular disease
+ diabetes mellitus
+ hyperlipidemia
+ intestinal disease
+ kidney disease
+ liver disease
+ metabolic syndrome
+ non-cholesterol sterols
+ plant sterols
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Non-cholesterol sterols are validated biomarkers for intestinal cholesterol absorption and endogenous cholesterol synthesis. However, their use in metabolic disturbances has not been systematically explored. Therefore, we conducted a systematic review to provide an overview of non-cholesterol sterols as markers for cholesterol metabolism in different metabolic disorders. Potentially relevant studies were retrieved by a systematic search of three databases in July 2018 and ninety-four human studies were included. Cholesterol-standardized levels of campesterol, sitosterol and cholestanol were collected to reflect cholesterol absorption and those of lathosterol and desmosterol to reflect cholesterol synthesis. Their use as biomarkers was examined in the following metabolic disorders: overweight/obesity (n = 16), diabetes mellitus (n = 15), metabolic syndrome (n = 5), hyperlipidemia (n = 11), cardiovascular disease (n = 17), and diseases related to intestine (n = 16), liver (n = 22) or kidney (n = 2). In general, markers for cholesterol absorption and synthesis displayed reciprocal patterns, showing that cholesterol metabolism is tightly regulated by the interplay of intestinal absorption and endogenous synthesis. Distinctive patterns for cholesterol absorption or cholesterol synthesis could be identified, suggesting that metabolic disorders can be classified as 'cholesterol absorbers or cholesterol synthesizers'. Future studies should be performed to confirm or refute these findings and to examine whether this information can be used for targeted (dietary) interventions.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phytosterols). 0 (Sitosterols). 0 (Sterols). 313-04-2 (Desmosterol). 5L5O665639 (campesterol). 5LI01C78DD (gamma-sitosterol). 80-99-9 (lathosterol). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11010124
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mashnafi&issn=2072-6643&title=Nutrients&atitle=Non-Cholesterol+Sterol+Concentrations+as+Biomarkers+for+Cholesterol+Absorption+and+Synthesis+in+Different+Metabolic+Disorders%3A+A+Systematic+Review.&volume=11&issue=1&spage=&epage=&date=2019&doi=10.3390%2Fnu11010124&pmid=30634478&sid=OVID:medline
+
+<1814>
+Unique Identifier
+ 30633318
+Title
+ Novel inflammatory biomarkers may reflect subclinical inflammation in young healthy adults with obesity.
+Source
+ Endokrynologia Polska. 70(2):135-142, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Osadnik T; Bujak K; Osadnik K; Czarnecka H; Pawlas N; Regula R; Fronczek M; Lejawa M; Gawlita M; Gonera M; Goral M; Strzelczyk JK; Gierlotka M; Lekston A; Kasperczyk J; Polonski L; Gasior M
+Authors Full Name
+ Osadnik, Tadeusz; Bujak, Kamil; Osadnik, Kamila; Czarnecka, Hanna; Pawlas, Natalia; Regula, Rafal; Fronczek, Martyna; Lejawa, Mateusz; Gawlita, Marcin; Gonera, Malgorzata; Goral, Marta; Strzelczyk, Joanna Katarzyna; Gierlotka, Marek; Lekston, Andrzej; Kasperczyk, Janusz; Polonski, Lech; Gasior, Mariusz.
+Institution
+ Osadnik, Tadeusz. 2nd Department of Cardiology and Angiology, Silesian Center for Heart Diseases, Zabrze, Poland. t.osadnik@wp.pl.
+ Osadnik, Tadeusz. Chair and Department of Pharmacology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland. t.osadnik@wp.pl.
+ Bujak, Kamil. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
+ Osadnik, Kamila. Chair and Department of Pharmacology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Czarnecka, Hanna. Clinical Laboratory, Silesian Center for Heart Diseases, Zabrze, Poland.
+ Pawlas, Natalia. Chair and Department of Pharmacology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Pawlas, Natalia. Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland.
+ Regula, Rafal. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
+ Fronczek, Martyna. Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Fronczek, Martyna. Genomics Laboratory, Kardio-Med Silesia Science and Technology Park, Zabrze, Poland.
+ Lejawa, Mateusz. Chair and Department of Pharmacology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Lejawa, Mateusz. Genomics Laboratory, Kardio-Med Silesia Science and Technology Park, Zabrze, Poland.
+ Gawlita, Marcin. Department of Environmental Medicine and Epidemiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Gonera, Malgorzata. Regional Specialised Hospital No. 4, Anaesthesiology and Intensive Care Unit, Bytom, Poland.
+ Goral, Marta. Students' Scientific Society, 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
+ Strzelczyk, Joanna Katarzyna. Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
+ Gierlotka, Marek. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
+ Gierlotka, Marek. Department of Cardiology, University Hospital in Opole, Faculty of Natural Sciences and Technology, Institute of Medicine, University of Opole, Poland.
+ Lekston, Andrzej. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
+ Kasperczyk, Janusz. Centre of Polymer and Carbon Materials of the Polish Academy of Sciences Zabrze, Poland.
+ Polonski, Lech. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
+ Gasior, Mariusz. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ Carotid Artery Diseases/bl [Blood]
+ *Cytokines/bl [Blood]
+ Female
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/im [Immunology]
+ *Inflammation Mediators/bl [Blood]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/im [Immunology]
+ Sex Factors
+ Young Adult
+Keyword Heading
+ complete blood count
+ inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obesity is often accompanied by low-grade inflammation. In recent years a few blood-based inflammatory markers - neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein ratio (MHR) - have been identified. They have been proven to correlate well with established inflammatory markers such as hsCRP and have a prognostic value among others in patients with coronary artery disease, heart failure, and malignancies. The aim of the study was to find markers associated with obesity in young heathy adults.
+
+ MATERIAL AND METHODS: The study group included 321 young healthy adults aged 18-35 years (210 males and 111 females). Partial least squares regression analysis was used to find variables associated with body mass index (BMI), except MHR. Analysed variables included complete blood count, lipid profile, sex hormone levels, acute-phase protein levels, and blood-based inflammatory markers.
+
+ RESULTS: Variables with the strongest association with BMI in the group of men were HDL% and apolipoprotein B, and in the group of women, HDL, HDL%, triglycerides, and MHR. Novel inflammatory markers were not associated with BMI. We found significant (p < 0.001) correlations between novel biomarkers (NLR, dNLR) and hsCRP and fibrinogen levels in the group of subjects with obesity.
+
+ CONCLUSIONS: Blood-based inflammatory markers significantly correlate with hsCRP and fibrinogen in young healthy adults with obesity, which may reflect the subclinical inflammation in this group of individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.5603%2fEP.a2019.0002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Osadnik&issn=0423-104X&title=Endokrynologia+Polska&atitle=Novel+inflammatory+biomarkers+may+reflect+subclinical+inflammation+in+young+healthy+adults+with+obesity.&volume=70&issue=2&spage=135&epage=142&date=2019&doi=10.5603%2FEP.a2019.0002&pmid=30633318&sid=OVID:medline
+
+<1815>
+Unique Identifier
+ 30625218
+Title
+ Dyslipidemia, subclinical inflammation, hepatic cholestasis and endothelial dysfunction in schoolchildren with excess fat: A study from the United Arab Emirates.
+Source
+ PLoS ONE [Electronic Resource]. 14(1):e0210316, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aburawi EH; Al Hamad S; Yasin J; Almekhaini LA; Souid AK
+Author NameID
+ Aburawi, Elhadi H; ORCID: https://orcid.org/0000-0001-5200-9048
+Authors Full Name
+ Aburawi, Elhadi H; Al Hamad, Sania; Yasin, Javed; Almekhaini, Lolowa A; Souid, Abdul-Kader.
+Institution
+ Aburawi, Elhadi H. Department of Pediatrics, College of Medicine and Health Sciences, UAE University, Alain, United Arab Emirates.
+ Al Hamad, Sania. Department of Pediatrics, College of Medicine and Health Sciences, UAE University, Alain, United Arab Emirates.
+ Yasin, Javed. Department of Medicine, College of Medicine and Health Sciences, UAE University, Alain, United Arab Emirates.
+ Almekhaini, Lolowa A. Department of Pediatrics, College of Medicine and Health Sciences, UAE University, Alain, United Arab Emirates.
+ Souid, Abdul-Kader. Department of Pediatrics, College of Medicine and Health Sciences, UAE University, Alain, United Arab Emirates.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ Cardiovascular Diseases/et [Etiology]
+ Child
+ *Cholestasis/ep [Epidemiology]
+ Comorbidity
+ Cross-Sectional Studies
+ *Dyslipidemias/ep [Epidemiology]
+ Endothelium, Vascular/pp [Physiopathology]
+ Female
+ Humans
+ Inflammation/ep [Epidemiology]
+ Male
+ Metabolic Syndrome/ep [Epidemiology]
+ *Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ Risk Factors
+ United Arab Emirates/ep [Epidemiology]
+Abstract
+ BACKGROUND: The impact of obesity on cardiovascular health of young children is still to be fully illustrated. This study measured biomarkers for glycemic control, lipid metabolism, systemic inflammation, endothelial dysfunction, and hepatic cholestasis in schoolchildren. Its main purpose was to determine whether metabolic derangements could be detected in young children with excess fat.
+
+ METHOD: This cross-sectional study involved 967 children in the second, sixth, and tenth grades (median age, 7.3, 11.3, and 15.4 years, respectively). Using the International Obesity Task Force interpretation (IOTF) of body-mass-index (BMI), children were stratified as thin (<5th centiles), normal (5th to <85th centiles), overweight (85th to <95th centiles), obese (95th to <98th centiles), or extremely-obese (>=98th centiles). Waist circumference was also measured. Several metabolic determinations were then used as surrogate biomarkers for cardiovascular risks.
+
+ RESULTS: Prevalence of BMI>=85th centile among the second graders was 13.1%, sixth graders 42.2%, and tenth graders 33.8%. BMI>=85th centile was associated with a tendency for higher hemoglobin A1c (p>=0.160) and higher blood glucose (p>=0.197). For the second graders, BMI>=85th centile was associated with higher high-sensitivity C-reactive protein (hs-CRP, p<0.001), higher tumor necrosis factor-alpha (TNF-alpha, p<0.001), higher interleukin-6 (IL-6, p<0.001), higher soluble intercellular cytoadhesive molecule-1 (sICAM-1), higher triglycerides (p<=0.024), and lower high-density lipoprotein (HDL, p<0.001). Additionally, for the sixth and tenth graders, BMI>=85th centile was associated with higher gamma-glutamyl transferase (GGT, p<0.001). In the sixth graders, BMI>=85th centile was insignificantly changed with sICAM-1 or the soluble vascular cytoadhesive molecule-1 (sVCAM-1).
+
+ CONCLUSIONS: The studied children with excess fat had increased risks for developing systemic inflammation, dyslipidemia, endothelial dysfunction, cholestasis, and diabetes. These results suggest that metabolic biomarkers should be included in the routine assessment of children with an overweight problem.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0210316
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aburawi&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Dyslipidemia%2C+subclinical+inflammation%2C+hepatic+cholestasis+and+endothelial+dysfunction+in+schoolchildren+with+excess+fat%3A+A+study+from+the+United+Arab+Emirates.&volume=14&issue=1&spage=e0210316&epage=&date=2019&doi=10.1371%2Fjournal.pone.0210316&pmid=30625218&sid=OVID:medline
+
+<1816>
+Unique Identifier
+ 30622318
+Title
+ Markers of subclinical vascular damages associate with indices of adiposity and blood pressure in obese children.
+Source
+ Hypertension Research - Clinical & Experimental. 42(3):400-410, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bonafini S; Giontella A; Tagetti A; Montagnana M; Benati M; Danese E; Minuz P; Maffeis C; Antoniazzi F; Fava C
+Authors Full Name
+ Bonafini, Sara; Giontella, Alice; Tagetti, Angela; Montagnana, Martina; Benati, Marco; Danese, Elisa; Minuz, Pietro; Maffeis, Claudio; Antoniazzi, Franco; Fava, Cristiano.
+Institution
+ Bonafini, Sara. Department of Medicine, University of Verona, Verona, Italy. bonafinisara@gmail.com.
+ Giontella, Alice. Department of Medicine, University of Verona, Verona, Italy.
+ Tagetti, Angela. Department of Medicine, University of Verona, Verona, Italy.
+ Montagnana, Martina. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
+ Benati, Marco. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
+ Danese, Elisa. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
+ Minuz, Pietro. Department of Medicine, University of Verona, Verona, Italy.
+ Maffeis, Claudio. Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
+ Antoniazzi, Franco. Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
+ Fava, Cristiano. Department of Medicine, University of Verona, Verona, Italy.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ *Biomarkers
+ *Blood Pressure
+ Body Mass Index
+ Carotid Intima-Media Thickness
+ Child
+ Cohort Studies
+ Female
+ Humans
+ Male
+ *Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ Overweight/pp [Physiopathology]
+ Plethysmography
+ Risk Factors
+ Ultrasonography
+ *Vascular Diseases/pp [Physiopathology]
+ *Vascular Stiffness
+ Vasodilation
+ Waist Circumference
+Keyword Heading
+ Arterial stiffness
+ Blood pressure
+ Children
+ Obesity
+ Pulse wave velocity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ In this observational study, we aimed at investigating the influence of excess weight and traditional cardiovascular risk factors on vascular structure and function in a cohort of overweight/obese children. Sixty-six obese and 4 overweight children (age 11.5 +/- 2.4 years; female n: 30) underwent office and ambulatory BP measurements (ABPM); ultrasound was used to measure carotid intima-media thickness (cIMT), endothelial function by Flow-Mediated Dilation (FMD) and carotid distensibility (cDC); and digital photopletismography was used to measure stiffness index (SIDVP). Carotid IMT directly correlated with 24-h and nighttime-systolic blood pressure (SBP); while cDC had inverse correlations with BMI, waist circumference and 24-h BP. Unexpectedly, SIDVP resulted inversely related with several indices of excess weight. Most of these correlations remained significant after adjustment for age, sex, BMI, and BP. In a replication set of 40 obese children, SIDVP but not pulse wave velocity (PWV) remained inversely associated with BMI. These data suggest that arterial structure and elasticity are negatively affected by excess weight and BP levels, even in childhood. Surprisingly, SI may not be a reliable marker of vascular stiffness in obese children, because this measurement is likely confounded by other factors, including vasodilation.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41440-018-0173-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bonafini&issn=0916-9636&title=Hypertension+Research+-+Clinical+%26+Experimental&atitle=Markers+of+subclinical+vascular+damages+associate+with+indices+of+adiposity+and+blood+pressure+in+obese+children.&volume=42&issue=3&spage=400&epage=410&date=2019&doi=10.1038%2Fs41440-018-0173-7&pmid=30622318&sid=OVID:medline
+
+<1817>
+Unique Identifier
+ 30617376
+Title
+ Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome. Relationships to insulin resistance and obesity.
+Source
+ Saudi Medical Journal. 40(1):19-25, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alotibi MN; Alnoury AM; Alhozali AM
+Authors Full Name
+ Alotibi, Maryam N; Alnoury, Amina M; Alhozali, Amani M.
+Institution
+ Alotibi, Maryam N. Department of Medicine, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail. mary.n_08@windowslive.com.
+MeSH Subject Headings
+ Adult
+ Aged
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ Body Mass Index
+ Body Weight
+ *Calcium-Binding Proteins/bl [Blood]
+ Case-Control Studies
+ *DNA-Binding Proteins/bl [Blood]
+ Fasting
+ Female
+ *Galanin/bl [Blood]
+ Glycated Hemoglobin
+ Humans
+ *Insulin Resistance
+ Male
+ *Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/et [Etiology]
+ Middle Aged
+ *Nerve Tissue Proteins/bl [Blood]
+ Nucleobindins
+ *Obesity/di [Diagnosis]
+ *Obesity/et [Etiology]
+ Waist Circumference
+Abstract
+ OBJECTIVES: To investigate the serum levels of nesfatin-1 and galanin in patients with metabolic syndrome (MetS), and also to show their association with the parameters of the disease. Methods: We performed a case-control study with 84 participants (44 patients with MetS diagnosed according to the American Heart Association/National Heart, Lung, and Blood Institute and International Diabetes Federation criteria and 40 control group) were recruited from King Abdulaziz University Hospital, Jeddah, Saudi Arabia, between October 2014 and June 2015. Anthropometric parameters, biochemical markers as well as nesfatin-1 and galanin were measured. Results: Nesfatin-1 levels were found to be significantly lower and galanin levels significantly higher in MetS group compared to the control group. A significant negative correlation between serum nesfatin-1 and weight, waist circumference, and body mass index were observed. A significant positive correlation between serum galanin and with fasting blood glucose, glycosylated hemoglobin, homeostasis model assessment-insulin resistance, and triglycerides. Conclusion : Our findings indicated a lower level of nesfatin-1 and a higher level of galanin in patients with MetS, suggesting a role of these neuropeptides in the pathogenesis of this disease.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Calcium-Binding Proteins). 0 (DNA-Binding Proteins). 0 (Glycated Hemoglobin A). 0 (NUCB2 protein, human). 0 (Nerve Tissue Proteins). 0 (Nucleobindins). 88813-36-9 (Galanin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.15537%2fsmj.2019.1.22825
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alotibi&issn=0379-5284&title=Saudi+Medical+Journal&atitle=Serum+nesfatin-1+and+galanin+concentrations+in+the+adult+with+metabolic+syndrome.+Relationships+to+insulin+resistance+and+obesity.&volume=40&issue=1&spage=19&epage=25&date=2019&doi=10.15537%2Fsmj.2019.1.22825&pmid=30617376&sid=OVID:medline
+
+<1818>
+Unique Identifier
+ 30613867
+Title
+ Bone metabolism markers are associated with neck circumference in adult Arab women.
+Source
+ Osteoporosis International. 30(4):845-852, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Albassam RS; Sabico S; Alnaami AM; Khattak MNK; Lei KY; Al-Daghri NM; Reginster JY; Alokail MS
+Author NameID
+ Al-Daghri, N M; ORCID: http://orcid.org/0000-0001-5472-1725
+Authors Full Name
+ Albassam, R S; Sabico, S; Alnaami, A M; Khattak, M N K; Lei, K Y; Al-Daghri, N M; Reginster, J-Y; Alokail, M S.
+Institution
+ Albassam, R S. Department of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA.
+ Albassam, R S. Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.
+ Sabico, S. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia.
+ Alnaami, A M. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia.
+ Khattak, M N K. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia.
+ Lei, K Y. Department of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA.
+ Al-Daghri, N M. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia. aldaghri2011@gmail.com.
+ Reginster, J-Y. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia.
+ Reginster, J-Y. Department of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium.
+ Alokail, M S. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Anthropometry/mt [Methods]
+ Biomarkers/bl [Blood]
+ Body Fat Distribution
+ Body Mass Index
+ *Bone Remodeling/ph [Physiology]
+ Bone Resorption/bl [Blood]
+ Bone Resorption/pa [Pathology]
+ Bone Resorption/pp [Physiopathology]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Middle Aged
+ *Neck/ah [Anatomy & Histology]
+ Neck/pa [Pathology]
+ Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ Obesity/pp [Physiopathology]
+Keyword Heading
+ Bone turnover markers
+ Neck
+ Obesity
+ Women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The study aimed to determine whether neck circumference is associated with bone metabolism markers among adult Arab women and found modest but significant associations with bone resorption markers, suggesting that neck circumference, a surrogate measure of upper subcutaneous fat, influences bone turnover expression among adult females.
+
+ INTRODUCTION: Body fat distribution is associated with decreased bone resorption and neck circumference (NC), a surrogate measure for upper body fat, has never been tested as a marker that can reflect bone turnover. This is the first study aimed to analyze the associations between NC and several bone biomarkers among adult Saudi women.
+
+ METHODS: This cross-sectional study included a total of 265 middle-aged Saudi women [86 non-obese (mean age 52.7 +/- 8.1; mean BMI 26.9 +/- 2.3) and 179 obese (mean age 50.6 +/- 7.5; mean BMI 35.7 +/- 4.5)] recruited from primary care centers in Riyadh, Saudi Arabia. Anthropometrics included BMI, NC, waist and hip circumferences, total body fat percentage (%), and blood pressure. Biochemical parameters included glucose and lipid profile which were measured routinely. Serum levels of 25(OH) D, parathyroid hormone, RANKl, sclerostin, C-terminal telopeptide of collagen I (CTX-I), Dkk1, IL1beta, osteoprotegerin, osteopontin, and osteocalcin were measured using commercially available assays.
+
+ RESULTS: In all groups, NC was inversely associated with PTH (R = - 0.22; p < 0.05) and positively associated with osteoprotegerin (R = 0.20; p < 0.05) even after adjustments for age and BMI. Using all anthropometric indices as independent variables showed that only NC explained the variance perceived in CTX-I (p = 0.049). In the non-obese, waist-hip ratio (WHR) was significantly associated with sclerostin (R = 0.40; p < 0.05) and body fat was significantly associated with osteopontin (R = 0.42; p < 0.05).
+
+ CONCLUSION: NC is modestly but significantly associated with bone biomarkers, particularly the bone resorption markers, among adult Arab women. The present findings highlight the importance of NC as measure of upper body subcutaneous fat in influencing bone biomarker expression in adult females.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00198-018-04830-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Albassam&issn=0937-941X&title=Osteoporosis+International&atitle=Bone+metabolism+markers+are+associated+with+neck+circumference+in+adult+Arab+women.&volume=30&issue=4&spage=845&epage=852&date=2019&doi=10.1007%2Fs00198-018-04830-6&pmid=30613867&sid=OVID:medline
+
+<1819>
+Unique Identifier
+ 30590687
+Title
+ A Diabetes-Related Dietary Pattern Is Associated with Incident Diabetes in Obese Men in the Korean Genome Epidemiology Study.
+Source
+ Journal of Nutrition. 149(2):323-329, 2019 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee HA; Son N; Lee WK; Park H
+Authors Full Name
+ Lee, Hye Ah; Son, NaYeong; Lee, Won Kyung; Park, Hyesook.
+Institution
+ Lee, Hye Ah. Clinical Trial Center, Mokdong Hospital.
+ Son, NaYeong. Departments of Statistics and.
+ Son, NaYeong. Office of Pharmacoepidemiology, Korea Institute of Drug Safety and Risk Management, Anyang-si, Korea.
+ Lee, Won Kyung. Department of Social and Preventive Medicine, Inha University School of Medicine, Incheon, Korea.
+ Park, Hyesook. Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ Cohort Studies
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ *Diet/ae [Adverse Effects]
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/ge [Genetics]
+ Republic of Korea/ep [Epidemiology]
+Keyword Heading
+ diabetes
+ dietary patterns
+ prospective cohort study
+ reduced rank regression
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Diet plays an important role in both the development and management of diabetes.
+
+ OBJECTIVE: Using data from the Korean Genome Epidemiology Study, we assessed dietary patterns associated with the clinical indicators of diabetes.
+
+ METHODS: This study included 7255 subjects aged 40-69 y. Individuals with chronic diseases were excluded. The daily intakes of specific food items were assessed using a dish-based semiquantitative food-frequency questionnaire comprising 103 items; the food items were then grouped into 26 food groups. Dietary patterns were analyzed by the reduced rank regression method using glycated hemoglobin, the homeostasis model of insulin resistance, and fasting glucose concentrations as dependent variables. We investigated the associations between dietary patterns and incident diabetes using the Cox proportional hazards model.
+
+ RESULTS: During an 11.5-y follow-up, the incidence of diabetes was 11.8/1000 person-years. The dietary pattern related to selected biomarkers of diabetes was characterized by a relatively high intake of kimchi, beef, other meat, fish, and coffee in men and a high intake of rice, kimchi, and fruit in women. In men, the association of dietary patterns with incident diabetes was significant only in the obese group, and those in the top quartile of the dietary pattern score had a 1.72 times (95% CI: 1.15, 2.56 times) greater risk of incident diabetes than those in the bottom quartile. Conversely, dietary patterns in women were not associated with incident diabetes.
+
+ CONCLUSION: Using reduced rank regression, we identified dietary patterns related to selected biomarkers of diabetes in a long-term study with follow-up data in Korea. Copyright © 2018 American Society for Nutrition.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fjn%2fnxy274
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=0022-3166&title=Journal+of+Nutrition&atitle=A+Diabetes-Related+Dietary+Pattern+Is+Associated+with+Incident+Diabetes+in+Obese+Men+in+the+Korean+Genome+Epidemiology+Study.&volume=149&issue=2&spage=323&epage=329&date=2019&doi=10.1093%2Fjn%2Fnxy274&pmid=30590687&sid=OVID:medline
+
+<1820>
+Unique Identifier
+ 30589657
+Title
+ Selective Associations of Recent Low Concentrations of Perfluoroalkyl Substances With Liver Function Biomarkers: NHANES 2011 to 2014 Data on US Adults Aged >=20 Years.
+Source
+ Journal of Occupational & Environmental Medicine. 61(4):293-302, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jain RB; Ducatman A
+Authors Full Name
+ Jain, Ram B; Ducatman, Alan.
+Institution
+ Jain, Ram B. Independent Researcher, Dacula, Georgia (Dr Jain); West Virginia University School of Public Health, Morgantown, West Virginia (Dr Ducatman).
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ Cross-Sectional Studies
+ *Environmental Exposure/ae [Adverse Effects]
+ Environmental Exposure/an [Analysis]
+ Environmental Exposure/sn [Statistics & Numerical Data]
+ Environmental Pollutants/bl [Blood]
+ *Environmental Pollutants/to [Toxicity]
+ Female
+ Fluorocarbons/bl [Blood]
+ *Fluorocarbons/to [Toxicity]
+ Hepatic Insufficiency/bl [Blood]
+ *Hepatic Insufficiency/ci [Chemically Induced]
+ Hepatic Insufficiency/co [Complications]
+ Hepatic Insufficiency/di [Diagnosis]
+ Humans
+ Liver Function Tests
+ Male
+ Middle Aged
+ Nutrition Surveys
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Risk Adjustment
+ Risk Factors
+ United States
+Abstract
+ OBJECTIVE: Perfluoroalkyl substances (PFAS) and liver function biomarkers were reexamined for relatively lower serum concentrations of PFAS observed in recent years.
+
+ METHODS: National Health and Nutrition Examination Survey 2011 to 2014 data were analyzed for obese and nonobese participants for serum perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorodecanoic acid (PFDA), perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA) as well as four liver function biomarkers in risk-adjusted analysis.
+
+ RESULTS: Among obese participants only, alanine aminotransferase (ALT) was positively associated with PFOA (beta = 0.07065, P < 0.01), PFHxS (beta = 0.051349, P < 0.01), and with PFNA (beta = 0.072742, P < 0.01). PFOA (beta = 0.07422, P = 0.03) and PFNA (beta = 0.077995, P < 0.01) were associated with gamma glutamyl transferase (GGT) in obese participants.
+
+ CONCLUSIONS: Recent lower levels of PFOA, PFHxS, and PFNA are associated with higher serum liver functions but only among obese participants. The findings are consistent with PFAS animal toxicology concerning steatosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Environmental Pollutants). 0 (Fluorocarbons).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fJOM.0000000000001532
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jain&issn=1076-2752&title=Journal+of+Occupational+%26+Environmental+Medicine&atitle=Selective+Associations+of+Recent+Low+Concentrations+of+Perfluoroalkyl+Substances+With+Liver+Function+Biomarkers%3A+NHANES+2011+to+2014+Data+on+US+Adults+Aged+%3E%3D20+Years.&volume=61&issue=4&spage=293&epage=302&date=2019&doi=10.1097%2FJOM.0000000000001532&pmid=30589657&sid=OVID:medline
+
+<1821>
+Unique Identifier
+ 30586726
+Title
+ Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial.
+Source
+ Circulation. 139(3):366-375, 2019 01 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Scirica BM; Bohula EA; Dwyer JP; Qamar A; Inzucchi SE; McGuire DK; Keech AC; Smith SR; Murphy SA; Im K; Leiter LA; Gupta M; Patel T; Miao W; Perdomo C; Bonaca MP; Ruff CT; Sabatine MS; Wiviott SD
+Corporate Author
+ CAMELLIA-TIMI 61 Steering Committee and Investigators
+Authors Full Name
+ Scirica, Benjamin M; Bohula, Erin A; Dwyer, Jamie P; Qamar, Arman; Inzucchi, Silvio E; McGuire, Darren K; Keech, Anthony C; Smith, Steven R; Murphy, Sabina A; Im, Kyungah; Leiter, Lawrence A; Gupta, Milan; Patel, Tushar; Miao, Wenfeng; Perdomo, Carlos; Bonaca, Marc P; Ruff, Christian T; Sabatine, Marc S; Wiviott, Stephen D.
+Institution
+ Scirica, Benjamin M. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+ Bohula, Erin A. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+ Dwyer, Jamie P. Division of Nephrology/Hypertension, Vanderbilt University Medical Center, Nashville, TN (J.P.D.).
+ Qamar, Arman. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+ Inzucchi, Silvio E. Section of Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.).
+ McGuire, Darren K. Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (D.K.M.).
+ Keech, Anthony C. NHMRC Clinical Trials Centre, University of Sydney, Australia (A.C.K.).
+ Smith, Steven R. Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando (S.R.S.).
+ Murphy, Sabina A. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+ Im, Kyungah. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+ Leiter, Lawrence A. Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Canada (L.A.L.).
+ Gupta, Milan. McMaster University, Hamilton, Ontario, Canada (M.G.).
+ Patel, Tushar. Eisai Inc, Woodcliff Lake, NJ (T.P., W.M., C.P.).
+ Miao, Wenfeng. Eisai Inc, Woodcliff Lake, NJ (T.P., W.M., C.P.).
+ Perdomo, Carlos. Eisai Inc, Woodcliff Lake, NJ (T.P., W.M., C.P.).
+ Bonaca, Marc P. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+ Ruff, Christian T. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+ Sabatine, Marc S. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+ Wiviott, Stephen D. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Appetite Depressants/ae [Adverse Effects]
+ *Appetite Depressants/tu [Therapeutic Use]
+ *Appetite Regulation/de [Drug Effects]
+ Benzazepines/ae [Adverse Effects]
+ *Benzazepines/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ Blood Pressure/de [Drug Effects]
+ Diet, Reducing
+ Disease Progression
+ Double-Blind Method
+ Female
+ *Glomerular Filtration Rate/de [Drug Effects]
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ *Kidney/de [Drug Effects]
+ Kidney/me [Metabolism]
+ Kidney/pp [Physiopathology]
+ *Kidney Diseases/ep [Epidemiology]
+ Kidney Diseases/mo [Mortality]
+ Kidney Diseases/pp [Physiopathology]
+ Male
+ Middle Aged
+ *Obesity/dt [Drug Therapy]
+ Obesity/mo [Mortality]
+ Obesity/pp [Physiopathology]
+ Obesity/px [Psychology]
+ Risk Assessment
+ Risk Factors
+ Risk Reduction Behavior
+ Serotonin 5-HT2 Receptor Agonists/ae [Adverse Effects]
+ *Serotonin 5-HT2 Receptor Agonists/tu [Therapeutic Use]
+ Time Factors
+ Treatment Outcome
+ Weight Loss/de [Drug Effects]
+Keyword Heading
+ albuminuria
+ kidney
+ obesity
+ serotonin receptor agonists
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is thought to increase renal hyperfiltration, thereby increasing albuminuria and the progression of renal disease. The effect of pharmacologically mediated weight loss on renal outcomes is not well-described. Lorcaserin, a selective serotonin 2C receptor agonist that promotes appetite suppression, led to sustained weight loss without any increased risk for major adverse cardiovascular (CV) events in the CAMELLIA-TIMI 61 trial (Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients-Thrombolysis in Myocardial Infarction 61).
+
+ METHODS: CAMELLIA-TIMI 61 randomly assigned 12 000 overweight or obese patients with or at high risk for atherosclerotic CV disease to lorcaserin or placebo on a background of lifestyle modification. The primary renal outcome was a composite of new or worsening persistent micro- or macroalbuminuria, new or worsening chronic kidney disease, doubling of serum creatinine, end-stage renal disease, renal transplant, or renal death.
+
+ RESULTS: At baseline, 23.8% of patients had an estimated glomerular filtration rate (eGFR) <60 mL.min-1.1.73 m-2 and 19.0% had albuminuria (urinary albumin:creatinine ratio >=30 mg/g). Lorcaserin reduced the risk of the primary renal composite outcome (4.2% per year versus 4.9% per year; hazard ratio [HR], 0.87; 95% confidence interval [CI], 0.79-0.96; P=0.0064). The benefit was consistent across subpopulations at increased baseline CV and renal risk. Lorcaserin improved both eGFR and urinary albumin:creatinune ratio within the first year after randomization. The effect of lorcaserin on weight, hemoglobin A1c, and systolic blood pressure was consistent regardless of baseline renal function. Likewise, there was no excess in cardiovascular events in patients assigned to lorcaserin in comparison with placebo, regardless of renal function. After adjustment for baseline characteristics, those with evidence of kidney disease were at increased risk of major CV events. Compared with patients with an eGFR >=90 mL.min-1.1.73 m-2, those with an eGFR 60-90 and those <60 mL.min-1.1.73 m-2 had HRs of 1.25 (95% CI, 1.01, 1.56) and 1.51 (95% CI, 1.17, 1.95), respectively ( P for trend 0.0015). Likewise, compared with patients with no albuminuria (<30 mg/g), those microalbuminuria and those with macroalbuminuria had HRs of 1.46 (95% CI, 1.22, 1.74) and 2.10 (95% CI, 1.58, 2.80), respectively ( P for trend <0.0001).
+
+ CONCLUSIONS: Renal dysfunction was associated with increased CV risk in overweight and obese patients. When added to diet and lifestyle, lorcaserin reduced the rate of new-onset or progressive renal impairment in comparison with placebo.
+
+ CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02019264.
+Registry Number/Name of Substance
+ 0 (Appetite Depressants). 0 (Benzazepines). 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Serotonin 5-HT2 Receptor Agonists). 0 (hemoglobin A1c protein, human). 637E494O0Z (lorcaserin).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1161%2fCIRCULATIONAHA.118.038341
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Scirica&issn=0009-7322&title=Circulation&atitle=Lorcaserin+and+Renal+Outcomes+in+Obese+and+Overweight+Patients+in+the+CAMELLIA-TIMI+61+Trial.&volume=139&issue=3&spage=366&epage=375&date=2019&doi=10.1161%2FCIRCULATIONAHA.118.038341&pmid=30586726&sid=OVID:medline
+
+<1822>
+Unique Identifier
+ 30586573
+Title
+ Diagnosis of obesity and use of obesity biomarkers in science and clinical medicine. [Review]
+Source
+ Metabolism: Clinical & Experimental. 92:61-70, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nimptsch K; Konigorski S; Pischon T
+Authors Full Name
+ Nimptsch, Katharina; Konigorski, Stefan; Pischon, Tobias.
+Institution
+ Nimptsch, Katharina. Molecular Epidemiology Research Group, Max Delbruck Center for Molecular Medicine (MDC), Berlin, Germany. Electronic address: katharina.nimptsch@mdc-berlin.de.
+ Konigorski, Stefan. Molecular Epidemiology Research Group, Max Delbruck Center for Molecular Medicine (MDC), Berlin, Germany; Digital Health - Machine Learning Group, Hasso-Plattner-Institute for Digital Engineering, Potsdam, Germany.
+ Pischon, Tobias. Molecular Epidemiology Research Group, Max Delbruck Center for Molecular Medicine (MDC), Berlin, Germany; Charite Universitatsmedizin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.
+MeSH Subject Headings
+ Adipokines
+ Anthropometry
+ *Biomarkers
+ Humans
+ *Obesity/di [Diagnosis]
+ *Obesity/th [Therapy]
+Keyword Heading
+ Adipokines
+ Cancer
+ Cardiovascular diseases
+ Chronic diseases
+ Inflammation
+ Insulin
+ Insulin-like growth factor-1
+ Obesity
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The global epidemic of obesity is a major public health problem today. Obesity increases the risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain types of cancer, and is associated with lower life expectancy. The body mass index (BMI), which is currently used to classify obesity, is only an imperfect measure of abnormal or excessive body fat accumulation. Studies have shown that waist circumference as a measure of fat distribution may improve disease prediction. More elaborate techniques such as magnetic resonance imaging are increasingly available to assess body fat distribution, but these measures are not readily available in routine clinical practice, and health-relevant cut-offs not yet been established. The measurement of biomarkers that reflect the underlying biological mechanisms for the increased disease risk may be an alternative approach to characterize the relevant obesity phenotype. The insulin/insulin-like growth factor (IGF) axis and chronic low-grade inflammation have been identified as major pathways. In addition, specific adipokines such as leptin, adiponectin and resistin have been related to obesity-associated health outcomes. This biomarker research, which is currently further developed with the application of high throughput methods, gives important insights in obesity-related disease etiology and pathophysiological pathways and may be used to better characterize obese persons at high risk of disease development and target disease-causing biomarkers in personalized prevention strategies. Copyright © 2018. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.metabol.2018.12.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nimptsch&issn=0026-0495&title=Metabolism%3A+Clinical+%26+Experimental&atitle=Diagnosis+of+obesity+and+use+of+obesity+biomarkers+in+science+and+clinical+medicine.&volume=92&issue=&spage=61&epage=70&date=2019&doi=10.1016%2Fj.metabol.2018.12.006&pmid=30586573&sid=OVID:medline
+
+<1823>
+Unique Identifier
+ 30585337
+Title
+ The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial.
+Source
+ Journal of Clinical Pharmacy & Therapeutics. 44(2):258-267, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hosseinpour-Arjmand S; Amirkhizi F; Ebrahimi-Mameghani M
+Authors Full Name
+ Hosseinpour-Arjmand, Sonya; Amirkhizi, Farshad; Ebrahimi-Mameghani, Mehrangiz.
+Institution
+ Hosseinpour-Arjmand, Sonya. Student Research Committee, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Amirkhizi, Farshad. Department of Nutrition, School of Public Health, Zabol University of Medical Sciences, Zabol, Iran.
+ Ebrahimi-Mameghani, Mehrangiz. Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Composition/de [Drug Effects]
+ Double-Blind Method
+ Female
+ Humans
+ *Inflammation/dt [Drug Therapy]
+ Interleukin-6/bl [Blood]
+ Male
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/dt [Drug Therapy]
+ Non-alcoholic Fatty Liver Disease/pp [Physiopathology]
+ *Obesity/pp [Physiopathology]
+ *Thioctic Acid/ad [Administration & Dosage]
+ Thioctic Acid/pd [Pharmacology]
+ Vitamin E/ad [Administration & Dosage]
+Keyword Heading
+ adiponectin
+ alpha-lipoic acid
+ inflammation
+ liver enzymes
+ non-alcoholic fatty liver
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ WHAT IS KNOWN AND OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury. Some animal studies suggest that alpha-lipoic acid (ALA) can improve disease outcome. The aim of this study was to investigate the effects of ALA supplementation on liver enzymes and inflammatory markers in obese patients with NAFLD.
+
+ METHODS: In the current randomized, double-blind, placebo-controlled clinical trial, 50 obese patients with NAFLD were randomly allocated to either "ALA"(received 1200 mg ALA as two capsules per day plus 400 mg vitamin E) or "placebo"(received placebo containing starch, as two capsules per day plus 400 mg vitamin E) groups for 12 weeks. Body composition and anthropometric measures, serum levels of liver enzymes, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and ferritin were measured at baseline and the end of the study.
+
+ RESULTS AND DISCUSSION: A total number of 45 patients completed the study (ALA group = 23; placebo group = 22). The serum concentration of IL-6 decreased significantly in ALA group in comparison with the placebo group, at end of the study (P = 0.049). Furthermore, ALA intake resulted in a significant increase in serum adiponectin levels compared to placebo (P = 0.008). A significant improvement was observed in liver steatosis grade of the patients in both groups, compared to baseline (P < 0.05). However, there was no difference between the two groups for the changes in liver steatosis, by the end of the study. Body composition and anthropometric measures, liver enzymes, MCP-1 and ferritin serum levels were not significantly different between the study groups, neither at the baseline nor at the end of the study.
+
+ WHAT IS NEW AND CONCLUSION: Collectively, ALA supplementation improved serum adiponectin and IL-6 levels, without changing serum liver enzymes and liver steatosis in obese patients with NAFLD. Copyright © 2018 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Interleukin-6). 1406-18-4 (Vitamin E). 73Y7P0K73Y (Thioctic Acid).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fjcpt.12784
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hosseinpour-Arjmand&issn=0269-4727&title=Journal+of+Clinical+Pharmacy+%26+Therapeutics&atitle=The+effect+of+alpha-lipoic+acid+on+inflammatory+markers+and+body+composition+in+obese+patients+with+non-alcoholic+fatty+liver+disease%3A+A+randomized%2C+double-blind%2C+placebo-controlled+trial.&volume=44&issue=2&spage=258&epage=267&date=2019&doi=10.1111%2Fjcpt.12784&pmid=30585337&sid=OVID:medline
+
+<1824>
+Unique Identifier
+ 30582317
+Title
+ Evaluation of Unfavorable Cardiovascular and Metabolic Risk Factors in Children and Young Adults with Haemophilia.
+Source
+ Journal of clinical research in pediatric endocrinology. 11(2):173-180, 2019 05 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yildiz M; Ozdemir N; Onal H; Koc B; Eliuz Tipici B; Zulfikar B
+Author NameID
+ Yildiz, Melek; ORCID: https://orcid.org/0000-0002-6603-2983
+ Ozdemir, Nihal; ORCID: https://orcid.org/0000-0002-3204-4353
+ Onal, Hasan; ORCID: https://orcid.org/0000-0001-9676-7086
+ Koc, Basak; ORCID: https://orcid.org/0000-0002-0978-7992
+ Eliuz Tipici, Beyza; ORCID: https://orcid.org/0000-0002-9790-7340
+ Zulfikar, Bulent; ORCID: https://orcid.org/0000-0002-7586-6939
+Authors Full Name
+ Yildiz, Melek; Ozdemir, Nihal; Onal, Hasan; Koc, Basak; Eliuz Tipici, Beyza; Zulfikar, Bulent.
+Institution
+ Yildiz, Melek. Istanbul University Cerrahpasa Faculty of Medicine, Department of Pediatrics, Istanbul, Turkey
+ Ozdemir, Nihal. Istanbul University Cerrahpasa Faculty of Medicine and Oncology Institute, Department of Pediatric Hematology and Oncology, Istanbul, Turkey
+ Onal, Hasan. Istanbul University Cerrahpasa Faculty of Medicine, Department of Pediatric Metabolism and Nutrition, Istanbul, Turkey
+ Koc, Basak. Istanbul University Cerrahpasa Faculty of Medicine, Department of Pediatrics, Istanbul, Turkey
+ Eliuz Tipici, Beyza. Istanbul University Istanbul Faculty of Medicine, Department of Nutrition and Dietetics, Istanbul, Turkey
+ Zulfikar, Bulent. Istanbul University Cerrahpasa Faculty of Medicine and Oncology Institute, Department of Pediatric Hematology and Oncology, Istanbul, Turkey
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/an [Analysis]
+ Blood Pressure
+ *Body Mass Index
+ *Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/et [Etiology]
+ Case-Control Studies
+ Child
+ Cross-Sectional Studies
+ Exercise
+ Female
+ Follow-Up Studies
+ *Hemophilia A/co [Complications]
+ Humans
+ *Insulin Resistance
+ Male
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ Nutrition Surveys
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Quality of Life
+ Risk Factors
+ Young Adult
+Keyword Heading
+ *obesity
+ *hypertension
+ *metabolic syndrome
+ Haemophilia
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: Increased risk of unfavorable cardiovascular risk factors has been recognised in ageing patients with haemophilia (PwH), but needs further studies in younger patients. The purpose of this study was to assess obesity, hypertension (HT), metabolic variables, insulin resistance and metabolic syndrome in young PwH.
+
+ Methods: Forty-eight haemophilia A and B patients and 35 age and sex matched healthy controls were included in the study. Anthropometric measurements, blood pressure (BP), fasting glucose and insulin levels, serum lipids and diet were evaluated. The metabolic syndrome was defined according to the criteria of the International Diabetes Federation for pediatric and adult age groups.
+
+ Results: The mean age of PwH was 21+/-9 years (range, 6-40 years). Of those >=18 years, 46% were were obese/overweight while there were no obese/overweight cases in the <18 year-old patients. Obesity was more prevalent in PwH with arthropathy (p=0.017). Seven percent of the PwH between 10 and 18 years-old and 25% of those >=18 years had metabolic syndrome. There was no difference in metabolic syndrome frequency between PwH and controls >10 years-old (19.5% vs 10% respectively, p=0.34). Fifty percent of the PwH >=18 years-old had elevated BP or HT. Fasting blood glucose levels of PwH were significantly higher compared to controls (p=0.02).
+
+ Conclusion: Our study showed that obesity, HT and metabolic syndrome are frequent problems, especially in PwH with arthropathy. Early prevention and management of overweight, obesity and their sequelae must be addressed in clinical practice in order to maximize the overall health of the haemophilia population.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Evaluation Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.4274%2fjcrpe.galenos.2018.2018.0292
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yildiz&issn=1308-5735&title=Journal+of+clinical+research+in+pediatric+endocrinology&atitle=Evaluation+of+Unfavorable+Cardiovascular+and+Metabolic+Risk+Factors+in+Children+and+Young+Adults+with+Haemophilia.&volume=11&issue=2&spage=173&epage=180&date=2019&doi=10.4274%2Fjcrpe.galenos.2018.2018.0292&pmid=30582317&sid=OVID:medline
+
+<1825>
+Unique Identifier
+ 30576001
+Title
+ Frontline Science: A reduction in DHA-derived mediators in male obesity contributes toward defects in select B cell subsets and circulating antibody.
+Source
+ Journal of Leukocyte Biology. 106(2):241-257, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Crouch MJ; Kosaraju R; Guesdon W; Armstrong M; Reisdorph N; Jain R; Fenton J; Shaikh SR
+Authors Full Name
+ Crouch, Miranda J; Kosaraju, Rasagna; Guesdon, William; Armstrong, Michael; Reisdorph, Nichole; Jain, Raghav; Fenton, Jenifer; Shaikh, Saame Raza.
+Institution
+ Crouch, Miranda J. Department of Biochemistry & Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
+ Crouch, Miranda J. East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
+ Crouch, Miranda J. Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+ Kosaraju, Rasagna. Department of Biochemistry & Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
+ Kosaraju, Rasagna. East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
+ Guesdon, William. Department of Biochemistry & Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
+ Guesdon, William. East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
+ Armstrong, Michael. Department of Pharmaceutical Sciences, University of Colorado, Denver, Colorado, USA.
+ Reisdorph, Nichole. Department of Pharmaceutical Sciences, University of Colorado, Denver, Colorado, USA.
+ Jain, Raghav. The College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA.
+ Fenton, Jenifer. The College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA.
+ Shaikh, Saame Raza. Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Animals
+ Antibodies/bl [Blood]
+ *Antibodies/im [Immunology]
+ B-Lymphocyte Subsets/de [Drug Effects]
+ *B-Lymphocyte Subsets/im [Immunology]
+ *B-Lymphocyte Subsets/me [Metabolism]
+ Biomarkers
+ Bone Marrow Cells/de [Drug Effects]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Disease Susceptibility
+ Docosahexaenoic Acids/aa [Analogs & Derivatives]
+ *Docosahexaenoic Acids/me [Metabolism]
+ Docosahexaenoic Acids/pd [Pharmacology]
+ Female
+ Germinal Center/cy [Cytology]
+ Germinal Center/im [Immunology]
+ Germinal Center/me [Metabolism]
+ Humans
+ Immunophenotyping
+ *Inflammation Mediators/me [Metabolism]
+ Lipid Metabolism
+ Lymphocyte Activation
+ Lymphocyte Count
+ Male
+ Metabolomics/mt [Methods]
+ Mice
+ Mice, Knockout
+ Mice, Obese
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Phenotype
+ Sex Factors
+Keyword Heading
+ 14-HDHA
+ 17-HDHA
+ PDX
+ n-3 polyunsaturated fatty acids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity dysregulates B cell populations, which contributes toward poor immunological outcomes. We previously reported that differing B cell subsets are lowered in the bone marrow of obese male mice. Here, we focused on how lipid metabolites synthesized from docosahexaenoic acid (DHA) known as specialized pro-resolving lipid mediators (SPMs) influence specific B cell populations in obese male mice. Metabololipidomics revealed that splenic SPM precursors 14-hydroxydocosahexaenoic acid (14-HDHA), 17-hydroxydocosahexaenoic acid (17-HDHA), and downstream protectin DX (PDX) were decreased in obese male C57BL/6J mice. Simultaneous administration of these mediators to obese mice rescued major decrements in bone marrow B cells, modest impairments in the spleen, and circulating IgG2c, which is pro-inflammatory in obesity. In vitro studies with B cells, flow cytometry experiments with ALOX5-/- mice, and lipidomic analyses revealed the lowering of 14-HDHA/17-HDHA/PDX and dysregulation of B cell populations in obesity was driven indirectly via B cell extrinsic mechanisms. Notably, the lowering of lipid mediators was associated with an increase in the abundance of n-6 polyunsaturated fatty acids, which have a high affinity for SPM-generating enzymes. Subsequent experiments revealed female obese mice generally maintained the levels of SPM precursors, B cell subsets, and antibody levels. Finally, obese human females had increased circulating plasma cells accompanied by ex vivo B cell TNFalpha and IL-10 secretion. Collectively, the data demonstrate that DHA-derived mediators of the SPM pathway control the number of B cell subsets and pro-inflammatory antibody levels in obese male but not female mice through a defect that is extrinsic to B cells. Copyright ©2018 Society for Leukocyte Biology.
+Registry Number/Name of Substance
+ 0 (Antibodies). 0 (Biomarkers). 0 (Inflammation Mediators). 25167-62-8 (Docosahexaenoic Acids). 86360-66-9 (14-hydroxydocosahexaenoic acid). 90780-52-2 (17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fJLB.3HI1017-405RR
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Crouch&issn=0741-5400&title=Journal+of+Leukocyte+Biology&atitle=Frontline+Science%3A+A+reduction+in+DHA-derived+mediators+in+male+obesity+contributes+toward+defects+in+select+B+cell+subsets+and+circulating+antibody.&volume=106&issue=2&spage=241&epage=257&date=2019&doi=10.1002%2FJLB.3HI1017-405RR&pmid=30576001&sid=OVID:medline
+
+<1826>
+Unique Identifier
+ 30573517
+Title
+ Intraindividual Variation in Markers of Intestinal Permeability and Adipose Tissue Inflammation in Healthy Normal-Weight to Obese Adults.
+Source
+ Cancer Epidemiology, Biomarkers & Prevention. 28(3):610-615, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kuzma JN; Hagman DK; Cromer G; Breymeyer KL; Roth CL; Foster-Schubert KE; Holte SE; Weigle DS; Kratz M
+Author NameID
+ Kuzma, Jessica N; ORCID: https://orcid.org/0000-0003-0897-3512
+ Kratz, Mario; ORCID: https://orcid.org/0000-0003-2660-8033
+Authors Full Name
+ Kuzma, Jessica N; Hagman, Derek K; Cromer, Gail; Breymeyer, Kara L; Roth, Christian L; Foster-Schubert, Karen E; Holte, Sarah E; Weigle, David S; Kratz, Mario.
+Institution
+ Kuzma, Jessica N. Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
+ Kuzma, Jessica N. Department of Epidemiology, University of Washington, Seattle, Washington.
+ Hagman, Derek K. Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
+ Cromer, Gail. Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
+ Breymeyer, Kara L. Prevention Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
+ Roth, Christian L. Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington.
+ Foster-Schubert, Karen E. Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington.
+ Holte, Sarah E. Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
+ Weigle, David S. Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington.
+ Kratz, Mario. Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. mkratz@fredhutch.org.
+ Kratz, Mario. Department of Epidemiology, University of Washington, Seattle, Washington.
+ Kratz, Mario. Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington.
+MeSH Subject Headings
+ Acute-Phase Proteins
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pp [Physiopathology]
+ Adult
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ Carrier Proteins/bl [Blood]
+ Case-Control Studies
+ *Cell Membrane Permeability
+ Diet
+ Female
+ Follow-Up Studies
+ Haptoglobins
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/pp [Physiopathology]
+ *Intestines/pa [Pathology]
+ Male
+ Membrane Glycoproteins/bl [Blood]
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ Overweight/bl [Blood]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ Protein Precursors/bl [Blood]
+Abstract
+ BACKGROUND: Intestinal permeability and adipose tissue inflammation are considered mechanistic links in the relationship between diet, obesity, and chronic disease. However, methods to measure both are not well standardized, and the reliability of commonly used measures is not known.
+
+ METHODS: We calculated the intraclass correlation coefficient (ICC) for several common measures of intestinal permeability and adipose tissue inflammation from a randomized clinical trial of cross-over design in which normal-weight (n = 12) or overweight/obese (n = 12) individuals each completed three 8-day dietary intervention periods.
+
+ RESULTS: For biomarkers of intestinal permeability, plasma zonulin, and lipopolysaccharide-binding protein, ICCs were "excellent" (i.e., >0.9). The direct measure of intestinal permeability, the lactulose/mannitol test, exhibited "fair" reliability (ICC = 0.53). A wider range of ICCs (0.6-0.9), suggesting "good" to "excellent" reliability, were obtained for measures of adipose tissue expression of genes encoding major mediators of inflammation. Similarly, individual immune cell populations isolated from adipose tissue, expressed as a percentage of all CD45+ cells, also had "good" to "excellent" ICCs. However, when these populations were expressed as number of cells per gram of tissue, ICC values were "fair," falling below 0.6.
+
+ CONCLUSIONS: Due to the repeated measures design, our study offered a unique opportunity to assess reliability of commonly used biomarkers of intestinal permeability and adipose tissue inflammation. Our findings suggest that these measures were generally highly reliable in the short-term.
+
+ IMPACT: Along with other factors, particularly validity, the demonstrated reliabilities can help inform the choice of endpoints in studies of intestinal permeability and adipose tissue inflammation. Copyright ©2018 American Association for Cancer Research.
+Registry Number/Name of Substance
+ 0 (Acute-Phase Proteins). 0 (Biomarkers). 0 (Carrier Proteins). 0 (Haptoglobins). 0 (Membrane Glycoproteins). 0 (Protein Precursors). 0 (lipopolysaccharide-binding protein). 0 (zonulin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1158%2f1055-9965.EPI-18-0641
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kuzma&issn=1055-9965&title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&atitle=Intraindividual+Variation+in+Markers+of+Intestinal+Permeability+and+Adipose+Tissue+Inflammation+in+Healthy+Normal-Weight+to+Obese+Adults.&volume=28&issue=3&spage=610&epage=615&date=2019&doi=10.1158%2F1055-9965.EPI-18-0641&pmid=30573517&sid=OVID:medline
+
+<1827>
+Unique Identifier
+ 30569635
+Title
+ Oxidized HDL, Adipokines, and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity.
+Source
+ Obesity. 27(1):87-93, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Peterson SJ; Shapiro JI; Thompson E; Singh S; Liu L; Weingarten JA; O'Hanlon K; Bialczak A; Bhesania SR; Abraham NG
+Author NameID
+ Peterson, Stephen J; ORCID: https://orcid.org/0000-0002-6847-3969
+Authors Full Name
+ Peterson, Stephen J; Shapiro, Joseph I; Thompson, Ellen; Singh, Shailendra; Liu, Lu; Weingarten, Jeremy A; O'Hanlon, Kathleen; Bialczak, Angelica; Bhesania, Siddharth R; Abraham, Nader G.
+Institution
+ Peterson, Stephen J. Weill Cornell Medical College, New York, New York, USA.
+ Peterson, Stephen J. New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.
+ Shapiro, Joseph I. Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
+ Thompson, Ellen. Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
+ Singh, Shailendra. Departments of Medicine and Pharmacology, New York Medical College, Valhalla, New York, USA.
+ Liu, Lu. Departments of Medicine and Pharmacology, New York Medical College, Valhalla, New York, USA.
+ Weingarten, Jeremy A. Weill Cornell Medical College, New York, New York, USA.
+ Weingarten, Jeremy A. New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.
+ O'Hanlon, Kathleen. Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
+ Bialczak, Angelica. Departments of Medicine and Pharmacology, New York Medical College, Valhalla, New York, USA.
+ Bhesania, Siddharth R. New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.
+ Abraham, Nader G. Departments of Medicine and Pharmacology, New York Medical College, Valhalla, New York, USA.
+MeSH Subject Headings
+ *Adipokines/me [Metabolism]
+ Animals
+ *Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/me [Metabolism]
+ *Endothelial Cells/me [Metabolism]
+ Female
+ Humans
+ *Lipoproteins, HDL/me [Metabolism]
+ *Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ Risk Factors
+Abstract
+ OBJECTIVE: High BMI predicts adverse cardiovascular outcomes and positively correlates with increased levels of adipokines. The relationship among BMI, IL-6, TNFalpha, adiponectin, and oxidized high-density lipoprotein (Ox-HDL) with circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) has not been well studied. Elevated CEC levels have been described in both humans and mice with obesity and diabetes. Ox-HDL has been shown to be a potent driver of adipogenesis in vivo and in vitro. In this study, elevated BMI was examined in 2 groups of women studied in Brooklyn, New York, and Huntington, West Virginia, respectively.
+
+ METHODS: Twenty-six females with obesity and five lean controls without overt cardiovascular disease were enrolled, 13 from Huntington and 13 from Brooklyn. Cytokine levels, EPCs, and CECs were determined.
+
+ RESULTS: Females with obesity had elevated levels of leptin, IL-6, and Ox-HDL, increased CEC levels, and decreased EPC and adiponectin levels (all P < 0.01). The Ox-HDL levels were higher in women from Brooklyn versus Huntington (P < 0.01), possibly from higher TNFalpha levels in Brooklyn or higher adiponectin levels in Huntington. Seventy-five percent of the variance in Ox-HDL levels could be predicted in this population (P < 0.01).
+
+ CONCLUSIONS: This study reveals a unique inflammatory biomarker profile in females with obesity. Copyright © 2018 The Obesity Society.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Lipoproteins, HDL).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2foby.22354
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Peterson&issn=1930-7381&title=Obesity&atitle=Oxidized+HDL%2C+Adipokines%2C+and+Endothelial+Dysfunction%3A+A+Potential+Biomarker+Profile+for+Cardiovascular+Risk+in+Women+with+Obesity.&volume=27&issue=1&spage=87&epage=93&date=2019&doi=10.1002%2Foby.22354&pmid=30569635&sid=OVID:medline
+
+<1828>
+Unique Identifier
+ 30568260
+Title
+ Personalized nutrition: pretreatment glucose metabolism determines individual long-term weight loss responsiveness in individuals with obesity on low-carbohydrate versus low-fat diet.
+Source
+ International Journal of Obesity. 43(10):2037-2044, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hjorth MF; Astrup A; Zohar Y; Urban LE; Sayer RD; Patterson BW; Herring SJ; Klein S; Zemel BS; Foster GD; Wyatt HR; Hill JO
+Author NameID
+ Hjorth, Mads F; ORCID: http://orcid.org/0000-0001-9440-2737
+ Astrup, Arne; ORCID: http://orcid.org/0000-0001-8968-8996
+Authors Full Name
+ Hjorth, Mads F; Astrup, Arne; Zohar, Yishai; Urban, Lorien E; Sayer, R Drew; Patterson, Bruce W; Herring, Sharon J; Klein, Samuel; Zemel, Babette S; Foster, Gary D; Wyatt, Holly R; Hill, James O.
+Institution
+ Hjorth, Mads F. Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen, Copenhagen, Denmark. madsfiil@nexs.ku.dk.
+ Astrup, Arne. Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen, Copenhagen, Denmark.
+ Zohar, Yishai. Gelesis, Boston, MA, USA.
+ Urban, Lorien E. Gelesis, Boston, MA, USA.
+ Sayer, R Drew. University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
+ Patterson, Bruce W. Washington University School of Medicine, St. Louis, MO, USA.
+ Herring, Sharon J. Temple University, Philadelphia, PA, USA.
+ Klein, Samuel. Washington University School of Medicine, St. Louis, MO, USA.
+ Zemel, Babette S. University of Pennsylvania, Philadelphia, PA, USA.
+ Foster, Gary D. University of Pennsylvania, Philadelphia, PA, USA.
+ Wyatt, Holly R. University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
+ Hill, James O. University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Diet, Carbohydrate-Restricted
+ *Diet, Fat-Restricted
+ *Fasting/bl [Blood]
+ Female
+ Humans
+ *Insulin/bl [Blood]
+ Male
+ Middle Aged
+ Nutrients
+ Obesity/bl [Blood]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pc [Prevention & Control]
+ Precision Medicine
+ Predictive Value of Tests
+ Retrospective Studies
+ *Weight Loss/ph [Physiology]
+Abstract
+ BACKGROUND/OBJECTIVES: The interaction between fasting plasma glucose (FPG) and fasting insulin (FI) concentrations and diets with different carbohydrate content were studied as prognostic markers of weight loss as recent studies up to 6 months of duration have suggested the importance of these biomarkers.
+
+ SUBJECTS/METHODS: This was a retrospective analysis of a clinical trial where participants with obesity were randomized to an ad libitum low-carbohydrate diet or a low-fat diet with low energy content (1200-1800 kcal/day [= 5.0-7.5 MJ/d]; <= 30% calories from fat) for 24 months. Participants were categorized (pretreatment) as normoglycemic (FPG < 5.6 mmol/L) or prediabetic (FPG >= 5.6-6.9 mmol/L) and further stratified by median FI. Linear mixed models were used to examine outcomes by FPG and FI values.
+
+ RESULTS: After 2 years, participants with prediabetes and high FI lost 7.2 kg (95% CI 2.1;12.2, P = 0.005) more with the low-fat than low-carbohydrate diet, whereas those with prediabetes and low FI tended to lose 6.2 kg (95% CI -0.9;13.3, P = 0.088) more on the low-carbohydrate diet than low-fat diet [mean difference: 13.3 kg (95% CI 4.6;22.0, P = 0.003)]. No differences between diets were found among participants with normoglycemia and either high or low FI (both P >= 0.16).
+
+ CONCLUSIONS: Fasting plasma glucose and insulin are strong predictors of the weight loss response to diets with different macronutrient composition and might be a useful approach for personalized weight management.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0298-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hjorth&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Personalized+nutrition%3A+pretreatment+glucose+metabolism+determines+individual+long-term+weight+loss+responsiveness+in+individuals+with+obesity+on+low-carbohydrate+versus+low-fat+diet.&volume=43&issue=10&spage=2037&epage=2044&date=2019&doi=10.1038%2Fs41366-018-0298-4&pmid=30568260&sid=OVID:medline
+
+<1829>
+Unique Identifier
+ 30566253
+Title
+ Omentin-1 level in adolescents with polycystic ovarian syndrome.
+Source
+ Pediatrics International. 61(2):147-151, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ozgen IT; Oruclu S; Selek S; Kutlu E; Guzel G; Cesur Y
+Author NameID
+ Ozgen, Ilker Tolga; ORCID: https://orcid.org/0000-0001-6592-9652
+ Kutlu, Esra; ORCID: https://orcid.org/0000-0002-4554-1631
+Authors Full Name
+ Ozgen, Ilker Tolga; Oruclu, Suera; Selek, Sahabettin; Kutlu, Esra; Guzel, Gulsum; Cesur, Yasar.
+Institution
+ Ozgen, Ilker Tolga. Division of Pediatric Endocrinology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
+ Oruclu, Suera. Department of Pediatrics, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
+ Selek, Sahabettin. Department of Biochemistry, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
+ Kutlu, Esra. Division of Pediatric Endocrinology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
+ Guzel, Gulsum. Department of Pediatrics, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
+ Cesur, Yasar. Division of Pediatric Endocrinology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ *Cytokines/bl [Blood]
+ Female
+ GPI-Linked Proteins/bl [Blood]
+ Humans
+ Hyperandrogenism/bl [Blood]
+ Hyperandrogenism/di [Diagnosis]
+ Hyperandrogenism/et [Etiology]
+ Insulin Resistance
+ *Lectins/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/co [Complications]
+ Testosterone/bl [Blood]
+Keyword Heading
+ hyperandrogenism
+ insulin resistance
+ omentin-1
+ polycystic ovarian syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Adipokines have been suggested to play an important role in the pathogenesis of polycystic ovarian syndrome (PCOS). Omentin is an adipokine secreted essentially by visceral adipose tissue with an insulin-sensitizing effect. Insulin resistance (IR) is a common feature of PCOS, therefore the aim of this study was to investigate omentin-1 level in adolescent girls with PCOS and its relationship with IR and androgens.
+
+ METHOD: A total of 41 obese girls with PCOS, and 30 age- and body mass index (BMI)-matched obese girls without PCOS were enrolled in the study. The demographic, clinic and laboratory characteristics of the groups were compared. Additionally, bivariate correlation analysis of omentin-1 with BMI standard deviation score (BMI-SDS), insulin, glucose, homeostatic model assessment of IR (HOMA-IR), total and free testosterone was performed.
+
+ RESULTS: In the PCOS group HOMA-IR, free and total testosterone were higher than in the control group. Omentin-1 was lower in the PCOS group compared with the controls (55.01 +/- 7.99 ng/mL vs 59.10 +/- 7.02 ng/mL, respectively; P = 0.027). Omentin-1 was inversely correlated with free testosterone (r = -0.527, P = 0.030) and BMI-SDS (r = -0.241, P = 0.046) but it was not correlated with total testosterone, HOMA-IR, glucose, insulin or serum lipids.
+
+ CONCLUSION: Omentin-1 was lower in obese girls with PCOS and hyperandrogenism was associated with this condition. Copyright © 2018 Japan Pediatric Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (GPI-Linked Proteins). 0 (ITLN1 protein, human). 0 (Lectins). 3XMK78S47O (Testosterone).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fped.13761
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ozgen&issn=1328-8067&title=Pediatrics+International&atitle=Omentin-1+level+in+adolescents+with+polycystic+ovarian+syndrome.&volume=61&issue=2&spage=147&epage=151&date=2019&doi=10.1111%2Fped.13761&pmid=30566253&sid=OVID:medline
+
+<1830>
+Unique Identifier
+ 30561102
+Title
+ Salivary alpha-amylase and hormones levels of young adults with different body composition.
+Source
+ Journal of Texture Studies. 50(1):45-52, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lucas BL; Barbosa TS; Castelo PM; Gaviao MBD
+Author NameID
+ Lucas, Barbara de Lima; ORCID: https://orcid.org/0000-0003-2829-0508
+ Castelo, Paula Midori; ORCID: https://orcid.org/0000-0001-8703-2272
+ Gaviao, Maria Beatriz Duarte; ORCID: https://orcid.org/0000-0002-7546-5262
+Authors Full Name
+ Lucas, Barbara de Lima; Barbosa, Tais de Souza; Castelo, Paula Midori; Gaviao, Maria Beatriz Duarte.
+Institution
+ Lucas, Barbara de Lima. Health Science Special Unit, Federal University of Goias, Jatai, Goias, Brazil.
+ Lucas, Barbara de Lima. Department of Pediatric Dentistry, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil.
+ Barbosa, Tais de Souza. Department of Dentistry, Institute of Life Sciences, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, Brazil.
+ Barbosa, Tais de Souza. Department of Pediatric Dentistry, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil.
+ Castelo, Paula Midori. Department of Pharmaceutical Sciences, Federal University of Sao Paulo (UNIFESP), Diadema, Sao Paulo, Brazil.
+ Castelo, Paula Midori. Department of Pediatric Dentistry, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil.
+ Gaviao, Maria Beatriz Duarte. Department of Pediatric Dentistry, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ *Biomarkers/an [Analysis]
+ *Body Composition
+ Brazil
+ Female
+ *Hormones/an [Analysis]
+ Humans
+ Hydrocortisone
+ Male
+ Obesity
+ Overweight
+ Saliva/ch [Chemistry]
+ Saliva/en [Enzymology]
+ *Salivary alpha-Amylases/an [Analysis]
+ Steroids/an [Analysis]
+ Young Adult
+Keyword Heading
+ adiposity
+ alpha-amylase
+ saliva
+ skinfold thickness
+ steroids
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The aim of this study was to assess the differences in salivary biomarker levels of young adults classified according to body fat accumulation. One hundred and thirty-four volunteers were evaluated (mean age 21 +/- 2 years). Body composition was calculated through skinfold thickness: supra-iliac, biceps, and triceps, sub-scapular. Body fat percentage (BF%) was used to classify subjects according to fat tissue accumulation: normal-weight (n = 37, 19 females, 18 males), overweight (n = 42, 30 females, 12 males), and obese (n = 55, 42 females, 13 males). Saliva samples were collected 30 min after awakening to determine salivary levels of 17-beta-estradiol. For salivary cortisol and alpha-amylase activity (sAA) three samples were obtained, just after awakening, 30 min after awakening and at bedtime. Oral contraceptive intake was considered for the female group. The results showed that overweight and obese females using oral contraceptive presented lower levels of 17-beta-estradiol than normal-weight females. In overweight and obese males, sAA levels were higher 30 min post-awakening when compared with the normal-weight group. The comparison of sAA levels within time showed no difference for males; obese females showed significant higher values at bedtime than 30 min post-awakening. The salivary cortisol concentration showed higher values at morning decreasing significantly at bedtime for all groups. Concluding, differences in 17-beta-estradiol and sAA levels were found in females and males, respectively, according to body fat accumulation, showing the usefulness of salivary biomarkers in the study of systemic conditions. PRACTICAL APPLICATIONS: Saliva is an advantageous biological fluid in innovative methods for diagnosis. Besides being a noninvasive method, salivary steroid measurements have the potential to provide a convenient assessment of serum free steroid concentrations. Copyright © 2018 Wiley Periodicals, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hormones). 0 (Steroids). EC 3-2-1-1 (Salivary alpha-Amylases). WI4X0X7BPJ (Hydrocortisone).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fjtxs.12384
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lucas&issn=0022-4901&title=Journal+of+Texture+Studies&atitle=Salivary+alpha-amylase+and+hormones+levels+of+young+adults+with+different+body+composition.&volume=50&issue=1&spage=45&epage=52&date=2019&doi=10.1111%2Fjtxs.12384&pmid=30561102&sid=OVID:medline
+
+<1831>
+Unique Identifier
+ 30561055
+Title
+ Oxidative stress and inflammation, two features associated with a high percentage body fat, and that may lead to diabetes mellitus and metabolic syndrome.
+Source
+ Biofactors. 45(1):35-42, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Darroudi S; Fereydouni N; Tayefi M; Ahmadnezhad M; Zamani P; Tayefi B; Kharazmi J; Tavalaie S; Heidari-Bakavoli A; Azarpajouh MR; Ferns GA; Mohammadpour AH; Esmaily H; Ghayour-Mobarhan M
+Author NameID
+ Darroudi, Susan; ORCID: https://orcid.org/0000-0002-5377-729X
+ Ghayour-Mobarhan, Majid; ORCID: https://orcid.org/0000-0002-1081-6754
+Authors Full Name
+ Darroudi, Susan; Fereydouni, Narges; Tayefi, Maryam; Ahmadnezhad, Mahsa; Zamani, Parvin; Tayefi, Batool; Kharazmi, Jasmin; Tavalaie, Shima; Heidari-Bakavoli, Alireza; Azarpajouh, Mahmoud R; Ferns, Gordon A; Mohammadpour, Amir H; Esmaily, Habibollah; Ghayour-Mobarhan, Majid.
+Institution
+ Darroudi, Susan. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Fereydouni, Narges. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Tayefi, Maryam. Department of Cardiovascular, Imam Reza Hospital, Mashhad University of Medical Science (MUMS), Mashhad, Iran.
+ Tayefi, Maryam. Head, University international Accreditation, International Office, Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ahmadnezhad, Mahsa. Nutrition research center, Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
+ Zamani, Parvin. Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Tayefi, Batool. Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
+ Kharazmi, Jasmin. Department of Biology, Mashhad Branch Islamic Azad University Mashhad, Iran.
+ Tavalaie, Shima. Metabolic Syndrome research center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Heidari-Bakavoli, Alireza. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Azarpajouh, Mahmoud R. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH, UK.
+ Ferns, Gordon A. Pharmaceutical Research Center, Pharmaceutical Institute Technology, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Mohammadpour, Amir H. Pharmaceutical Research Center, Pharmaceutical Institute Technology, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Mohammadpour, Amir H. Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Esmaily, Habibollah. Social Determinants of Health Research, Center, Mashhad University of Medical Sciences, Mashhad, Iran.
+ Ghayour-Mobarhan, Majid. Metabolic Syndrome research center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pp [Physiopathology]
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ Cholesterol, HDL/bl [Blood]
+ Cholesterol, LDL/bl [Blood]
+ Cohort Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ Female
+ Humans
+ Inflammation
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ *Oxidative Stress
+ Risk Factors
+ *Superoxide Dismutase-1/bl [Blood]
+ Triglycerides/bl [Blood]
+Keyword Heading
+ SOD1
+ metabolic syndrome
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is an important feature of the metabolic syndrome and is associated with an increased risk of type 2 diabetes mellitus, cardiovascular disease, and some cancers. The aim of this study was to determine the relationship between body fat percentage and an imbalance of the prooxidant/antioxidant balance (PAB), serum superoxide dismutase (SOD1) and inflammation (serum hs-CRP) and increase risk of metabolic syndrome and diabetes mellitus. In this study, 9154 individuals were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study. Subjects were categorized into two groups according to body fat percentage as defined >25% in male and > 30% in female, according to gender. Biochemical factors, including serum PAB, SOD1, and hs-CRP were measured in all subjects. SPSS version 18 was used for statistical analyses for all. GraphPad Prism 6 for figures was used. Of total number of subjects (9154), 6748 (73.7%) were found to have a high body fat (BF) percentage. Serum hs-CRP and PAB were significantly higher in individuals with a high BF percentage (P < 0.05) but SOD1 was not significantly different between the two groups (P > 0.05). BF percentage, serum PAB and serum hs-CRP were significantly higher in individuals with metabolic syndrome and diabetes versus those without metabolic syndrome and diabetes mellitus (P < 0.05), however serum SOD1 was significantly lower in individuals with metabolic syndrome (P < 0.005). Oxidative stress and inflammation are two factors that may link the presence of high BF percentage with the development of metabolic syndrome, diabetes, and cardiovascular disease. © 2018 BioFactors, 45(1):35-42, 2019. Copyright © 2018 International Union of Biochemistry and Molecular Biology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (SOD1 protein, human). 0 (Triglycerides). 9007-41-4 (C-Reactive Protein). EC 1-15-1-1 (Superoxide Dismutase-1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fbiof.1459
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Darroudi&issn=0951-6433&title=Biofactors&atitle=Oxidative+stress+and+inflammation%2C+two+features+associated+with+a+high+percentage+body+fat%2C+and+that+may+lead+to+diabetes+mellitus+and+metabolic+syndrome.&volume=45&issue=1&spage=35&epage=42&date=2019&doi=10.1002%2Fbiof.1459&pmid=30561055&sid=OVID:medline
+
+<1832>
+Unique Identifier
+ 30559024
+Title
+ Prevalence of Nonalcoholic Fatty Liver Disease in Children with Obesity.
+Source
+ Journal of Pediatrics. 207:64-70, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yu EL; Golshan S; Harlow KE; Angeles JE; Durelle J; Goyal NP; Newton KP; Sawh MC; Hooker J; Sy EZ; Middleton MS; Sirlin CB; Schwimmer JB
+Authors Full Name
+ Yu, Elizabeth L; Golshan, Shahrokh; Harlow, Kathryn E; Angeles, Jorge E; Durelle, Janis; Goyal, Nidhi P; Newton, Kimberly P; Sawh, Mary Catherine; Hooker, Jonathan; Sy, Ethan Z; Middleton, Michael S; Sirlin, Claude B; Schwimmer, Jeffrey B.
+Institution
+ Yu, Elizabeth L. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
+ Golshan, Shahrokh. Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA.
+ Harlow, Kathryn E. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
+ Angeles, Jorge E. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA.
+ Durelle, Janis. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA.
+ Goyal, Nidhi P. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
+ Newton, Kimberly P. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
+ Sawh, Mary Catherine. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
+ Hooker, Jonathan. Liver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, CA.
+ Sy, Ethan Z. Liver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, CA.
+ Middleton, Michael S. Liver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, CA.
+ Sirlin, Claude B. Liver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, CA.
+ Schwimmer, Jeffrey B. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA. Electronic address: jschwimmer@ucsd.edu.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adolescent
+ Alanine Transaminase/bl [Blood]
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ Child
+ Decision Trees
+ Female
+ Humans
+ Insulin/bl [Blood]
+ Magnetic Resonance Imaging/mt [Methods]
+ Male
+ Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ *Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Obesity/ep [Epidemiology]
+ Predictive Value of Tests
+ Prevalence
+Keyword Heading
+ BMI
+ NAFLD
+ pediatric
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To determine the prevalence of nonalcoholic fatty liver disease (NAFLD) in children with obesity because current estimates range from 1.7% to 85%. A second objective was to evaluate the diagnostic accuracy of alanine aminotransferase (ALT) for NAFLD in children with obesity.
+
+ STUDY DESIGN: We evaluated children aged 9-17 years with obesity for the presence of NAFLD. Diseases other than NAFLD were excluded by history and laboratories. Hepatic steatosis was measured by liver magnetic resonance imaging proton density fat fraction. The diagnostic accuracy of ALT for detecting NAFLD was evaluated.
+
+ RESULTS: The study included 408 children with obesity that had a mean age of 13.2 years and mean body mass index percentile of 98.0. The study population had a mean ALT of 32 U/L and median hepatic magnetic resonance imaging proton density fat fraction of 3.7%. The estimated prevalence of NAFLD was 26.0% (95% CI 24.2%-27.7%), 29.4% in male patients (CI 26.1%-32.7%) and 22.6% in female patients (CI 16.0%-29.1%). Optimal ALT cut-point was 42 U/L (47.8% sensitivity, 93.2% specificity) for male and 30 U/L (52.1% sensitivity, 88.8% specificity) for female patients. The classification and regression tree model with sex, ALT, and insulin had 80% diagnostic accuracy for NAFLD.
+
+ CONCLUSIONS: NAFLD is common in children with obesity, but NAFLD and obesity are not concomitant. In children with obesity, NAFLD is present in nearly one-third of boys and one-fourth of girls. Copyright © 2018 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.jpeds.2018.11.021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yu&issn=0022-3476&title=Journal+of+Pediatrics&atitle=Prevalence+of+Nonalcoholic+Fatty+Liver+Disease+in+Children+with+Obesity.&volume=207&issue=&spage=64&epage=70&date=2019&doi=10.1016%2Fj.jpeds.2018.11.021&pmid=30559024&sid=OVID:medline
+
+<1833>
+Unique Identifier
+ 30549421
+Title
+ Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
+Source
+ Diabetes/Metabolism Research Reviews. 35(3):e3117, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen L; Lu B; Yang Y; Zhang W; Wang X; Zhou H; Wen J; Yang Z; Hu R
+Author NameID
+ Chen, Lili; ORCID: https://orcid.org/0000-0002-1800-4662
+Authors Full Name
+ Chen, Lili; Lu, Bin; Yang, Yehong; Zhang, Weiwei; Wang, Xuanchun; Zhou, Houguang; Wen, Jie; Yang, Zhen; Hu, Renming.
+Institution
+ Chen, Lili. Department of Endocrinology, Huashan Hospital Fudan University, Shanghai, China.
+ Chen, Lili. Institute of Endocrinology and Diabetology, Fudan University, Shanghai, China.
+ Lu, Bin. Department of Endocrinology, Huashan Hospital Fudan University, Shanghai, China.
+ Lu, Bin. Institute of Endocrinology and Diabetology, Fudan University, Shanghai, China.
+ Yang, Yehong. Department of Endocrinology, Huashan Hospital Fudan University, Shanghai, China.
+ Yang, Yehong. Institute of Endocrinology and Diabetology, Fudan University, Shanghai, China.
+ Zhang, Weiwei. Department of Endocrinology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
+ Wang, Xuanchun. Department of Endocrinology, Huashan Hospital Fudan University, Shanghai, China.
+ Wang, Xuanchun. Institute of Endocrinology and Diabetology, Fudan University, Shanghai, China.
+ Zhou, Houguang. Department of Geriatrics, Huashan Hospital Fudan University, Shanghai, China.
+ Wen, Jie. Department of Endocrinology, Huashan Hospital Fudan University, Shanghai, China.
+ Wen, Jie. Institute of Endocrinology and Diabetology, Fudan University, Shanghai, China.
+ Yang, Zhen. Department of Endocrinology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
+ Hu, Renming. Department of Endocrinology, Huashan Hospital Fudan University, Shanghai, China.
+ Hu, Renming. Institute of Endocrinology and Diabetology, Fudan University, Shanghai, China.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ *Cathepsins/bl [Blood]
+ China
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ Middle Aged
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prognosis
+Keyword Heading
+ cathepsin S
+ metabolic syndrome
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Cathepsin S is highly expressed in subcutaneous and visceral adipose tissue. Cathepsin S correlates with central obesity and contributes to the formation and progression of atherosclerosis. Here, we sought to evaluate the association of serum cathepsin S with metabolic syndrome (MS) in overweight and obese Chinese adults.
+
+ METHODS: We evaluated serum cathepsin S levels in a cross-sectional sample of 781 overweight and obese Chinese adults by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured.
+
+ RESULTS: Cathepsin S was significantly associated with BMI, waist circumference, waist-to-hip ratio, fasting glucose, fasting insulin, the homeostatic model assessment of insulin resistance (HOMA-IR), systolic blood pressure, C-reactive protein (CRP), triglycerides, and HDL cholesterol (all P < 0.05). Plasma cathepsin S levels increased significantly (P = 0.045 for trend) with increasing numbers of MS components after adjustment for potential confounders. In the highest cathepsin S quartile, the MS risk was significantly higher (odds ratio 2.30; 95% confidence interval, 1.89-2.78) than in the lowest quartile after adjustment for age, gender, alcohol consumption, smoking, education, physical activity, self-reported CVD, and family history of diabetes. This association remained strong (odds ratio 1.97; 95% confidence interval, 1.72-2.48) after controlling further for CRP, adiponectin, HOMA-IR, and BMI.
+
+ CONCLUSIONS: Elevated circulating cathepsin S concentrations are strongly and independently associated with MS in overweight and obese Chinese adults. Prospective studies are needed to establish the role of cathepsin S in the development of MS. Copyright © 2018 John Wiley & Sons, Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4 (Cathepsins). EC 3-4-22-27 (cathepsin S).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fdmrr.3117
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1520-7552&title=Diabetes%2FMetabolism+Research+Reviews&atitle=Elevated+circulating+cathepsin+S+levels+are+associated+with+metabolic+syndrome+in+overweight+and+obese+individuals.&volume=35&issue=3&spage=e3117&epage=&date=2019&doi=10.1002%2Fdmrr.3117&pmid=30549421&sid=OVID:medline
+
+<1834>
+Unique Identifier
+ 30548778
+Title
+ Clinical indices and local levels of inflammatory biomarkers in per-implant health of obese and nonobese individuals.
+Source
+ Clinical Implant Dentistry & Related Research. 21(1):80-84, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alasqah MN; Al-Shibani N; Al-Aali KA; Qutub OA; Abduljabbar T; Akram Z
+Author NameID
+ Abduljabbar, Tariq; ORCID: https://orcid.org/0000-0001-7266-5886
+ Akram, Zohaib; ORCID: https://orcid.org/0000-0001-9618-8818
+Authors Full Name
+ Alasqah, Mohammed N; Al-Shibani, Nouf; Al-Aali, Khulud Abdulrahman; Qutub, Osama A; Abduljabbar, Tariq; Akram, Zohaib.
+Institution
+ Alasqah, Mohammed N. Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia.
+ Al-Shibani, Nouf. Department of Periodontics and Community Dentistry, King Saud University, Riyadh, Saudi Arabia.
+ Al-Aali, Khulud Abdulrahman. Department of Prosthodontics, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
+ Qutub, Osama A. Oral and Maxillofacial Prosthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Abduljabbar, Tariq. Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
+ Akram, Zohaib. Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Case-Control Studies
+ *Dental Implantation, Endosseous/ae [Adverse Effects]
+ *Dental Implants/ae [Adverse Effects]
+ Dental Plaque Index
+ Female
+ *Gingival Crevicular Fluid/ch [Chemistry]
+ Humans
+ *Inflammation/co [Complications]
+ *Interleukin-1beta/an [Analysis]
+ *Interleukin-6/an [Analysis]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Periodontal Attachment Loss/co [Complications]
+ Periodontal Index
+ Periodontium/dg [Diagnostic Imaging]
+ Periodontium/me [Metabolism]
+ Radiography, Dental
+Keyword Heading
+ biomarkers
+ crestal bone loss
+ dental implants
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity seem to regulate peri-implant health. It is proposed that peri-implant crevicular fluid (PICF) levels of interleukin (IL)-1beta and IL-6 are higher in obese as compared to nonobese individuals.
+
+ OBJECTIVE: The purpose of the present clinico-laboratory study is to estimate and compare the clinical and radiographic indices and PICF levels of IL-1beta and IL-6 among obese and nonobese patients.
+
+ MATERIALS AND METHODS: Fifty patients were divided into two groups (25 obese with >=27.5 kg/m2 and 25 nonobese with <27.5 kg/m2 individuals). Clinical indices for both periodontal and peri-implant evaluating plaque index (PI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), and crestal bone loss (CBL) were recorded around teeth and implants. PICF was collected and assessed for the levels of IL-1beta and IL-6 using enzyme-linked immunosorbent assay.
+
+ RESULTS: A significant difference was observed in PI and BOP around natural teeth and implants in obese patients, respectively (P < .05). CBL was found to be significantly higher among obese as compared to nonobese patients (P = .022). Peri-implant and periodontal PD was higher in obese as compared to nonobese but did not reach statistical significance. Levels of IL-1beta and IL-6 were statistically significantly higher among obese patients as compared to nonobese (P = .001). Pearson correlation analysis showed IL-1beta was positively correlated with CBL (P = .0079), whereas IL-6 showed positive correlation with both BOP (P = .0019) and CBL (P = .015) among obese patients.
+
+ CONCLUSIONS: Clinical peri-implant parameters were worse and proinflammatory biomarkers were significantly higher in obese patients compared with nonobese subjects. The findings of the present study suggests that increased proinflammatory biomarkers in PICF of obese patients may modulate peri-implant inflammation around dental implants. Copyright © 2018 Wiley Periodicals, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dental Implants). 0 (Interleukin-1beta). 0 (Interleukin-6).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fcid.12700
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alasqah&issn=1523-0899&title=Clinical+Implant+Dentistry+%26+Related+Research&atitle=Clinical+indices+and+local+levels+of+inflammatory+biomarkers+in+per-implant+health+of+obese+and+nonobese+individuals.&volume=21&issue=1&spage=80&epage=84&date=2019&doi=10.1111%2Fcid.12700&pmid=30548778&sid=OVID:medline
+
+<1835>
+Unique Identifier
+ 30541116
+Title
+ Expression of GHR and Downstream Signaling Genes in Human Adipose Tissue-Relation to Obesity and Weight Change.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 104(5):1459-1470, 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Glad CAM; Svensson PA; Nystrom FH; Jacobson P; Carlsson LMS; Johannsson G; Andersson-Assarsson JC
+Authors Full Name
+ Glad, Camilla A M; Svensson, Per-Arne; Nystrom, Fredrik H; Jacobson, Peter; Carlsson, Lena M S; Johannsson, Gudmundur; Andersson-Assarsson, Johanna C.
+Institution
+ Glad, Camilla A M. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Glad, Camilla A M. Department of Endocrinology, Diabetes and Metabolism, Sahlgrenska University Hospital, Gothenburg, Sweden.
+ Svensson, Per-Arne. Department of Molecular and Clinical Medicine, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Svensson, Per-Arne. Institute of Health and Care Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Nystrom, Fredrik H. Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden.
+ Jacobson, Peter. Department of Molecular and Clinical Medicine, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Carlsson, Lena M S. Department of Molecular and Clinical Medicine, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Johannsson, Gudmundur. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Johannsson, Gudmundur. Department of Endocrinology, Diabetes and Metabolism, Sahlgrenska University Hospital, Gothenburg, Sweden.
+ Andersson-Assarsson, Johanna C. Department of Molecular and Clinical Medicine, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ *Adipose Tissue/pp [Physiopathology]
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ Carrier Proteins/ge [Genetics]
+ *Carrier Proteins/me [Metabolism]
+ Case-Control Studies
+ Cohort Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ STAT3 Transcription Factor/ge [Genetics]
+ *STAT3 Transcription Factor/me [Metabolism]
+ STAT5 Transcription Factor/ge [Genetics]
+ *STAT5 Transcription Factor/me [Metabolism]
+ Signal Transduction
+ Tumor Suppressor Proteins/ge [Genetics]
+ *Tumor Suppressor Proteins/me [Metabolism]
+ *Weight Gain
+ *Weight Loss
+Abstract
+ CONTEXT: GH is a strong regulator of metabolism. In obesity, both GH secretion and adipose tissue GHR gene expression are decreased. More detailed information on the regulation of GHR, STAT3/5, and downstream-regulated genes in human adipose tissue during diet-induced weight loss and weight gain is lacking.
+
+ OBJECTIVE: The aim of the present study was to investigate the gene expression patterns of GHR and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway (JAK2, STAT3, STAT5A, and STAT5B) in human subcutaneous adipose tissue in relation to energy restriction and overfeeding.
+
+ DESIGN, PATIENTS, AND INTERVENTIONS: Tissue distribution was analyzed in a data set generated by RNA sequencing containing information on global expression in human tissues. Subcutaneous adipose tissue or adipocyte gene expression (measured by DNA microarrays) was investigated in the following settings: (i) individuals with obesity vs individuals with normal weight; (ii) energy restriction; and (iii) overfeeding.
+
+ RESULTS: GHR expression was decreased in subjects with obesity compared with subjects with normal weight (P < 0.001). It was increased in response to energy restriction and decreased in response to overfeeding (P = 0.015 and P = 0.030, respectively). STAT3 expression was increased in subjects with obesity (P < 0.001). It was decreased during energy restriction and increased during overfeeding (P = 0.004 and P = 0.006, respectively). STAT3-regulated genes showed an overall view of overexpression in obesity.
+
+ CONCLUSIONS: The results of the present study have shown that GHR, STAT3, and STAT3-regulated genes are dynamically, and reciprocally, regulated at the tissue level in response to energy restriction and overfeeding, suggesting that GH signaling is perturbed in obesity. Copyright © 2019 Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Carrier Proteins). 0 (STAT3 Transcription Factor). 0 (STAT3 protein, human). 0 (STAT5 Transcription Factor). 0 (STAT5A protein, human). 0 (STAT5B protein, human). 0 (Tumor Suppressor Proteins). W06KFL3RDT (somatotropin-binding protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1210%2fjc.2018-01036
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Glad&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Expression+of+GHR+and+Downstream+Signaling+Genes+in+Human+Adipose+Tissue-Relation+to+Obesity+and+Weight+Change.&volume=104&issue=5&spage=1459&epage=1470&date=2019&doi=10.1210%2Fjc.2018-01036&pmid=30541116&sid=OVID:medline
+
+<1836>
+Unique Identifier
+ 30540625
+Title
+ Midregional proadrenomedullin predicts reduced blood pressure and glucose elevation over time despite enhanced progression of obesity markers.
+Source
+ Journal of Hypertension. 37(3):590-595, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ohlsson T; Nilsson PM; Persson M; Melander O
+Authors Full Name
+ Ohlsson, Therese; Nilsson, Peter M; Persson, Margaretha; Melander, Olle.
+Institution
+ Ohlsson, Therese. Department of Clinical Sciences, Malmo, Lund University, Malmo, Sweden.
+MeSH Subject Headings
+ *Adrenomedullin/bl [Blood]
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ *Blood Glucose/ph [Physiology]
+ *Blood Pressure/ph [Physiology]
+ Cross-Sectional Studies
+ Humans
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ *Obesity
+ *Protein Precursors/bl [Blood]
+Abstract
+ OBJECTIVES: Elevated plasma levels of the vasodilating hormone adrenomedullin (ADM) predict cardiovascular disease and have been associated with hypertension and obesity. We aimed to examine the independent relationship between ADM and the progression of major cardiometabolic risk factors during long-term follow-up.
+
+ METHODS: We studied midregional pro-ADM (MR-proADM) in fasting plasma in 3298 participants from the population-based Malmo Diet and Cancer Study - Cardiovascular Cohort, re-examined after 17 years of follow-up and related baseline MR-proADM to cardiometabolic risk factors cross-sectionally and longitudinally.
+
+ RESULTS: At baseline, after full adjustment, each SD increment of MR-proADM was independently related to (beta +/- standard error, P value) higher SBP (0.956 +/- 0.319 mmHg, P = 0.003), BMI (0.912 +/- 0.061 kg/m, P = 1.42 x 10), waist (2.28 +/- 0.158 cm, P = 8.46 x 10) and fasting blood glucose (0.046 +/- 0.018 mmol/l, P = 0.01). After full adjustment, including the baseline level of the risk factor whose degree of progression was studied, each SD increment of MR-proADM predicted significantly reduced progression of SBP (-1.170 +/- 0.337 mmHg, P = 0.001) and fasting blood glucose (-0.055 +/- 0.023 mmol/l, P = 0.015), but greater increase of BMI (0.101 +/- 0.051 kg/m, P = 0.047) and waist (0.600 +/- 0.144 cm, P = 3.1 x 10).
+
+ CONCLUSION: Despite cross-sectional associations with higher levels of blood pressure and glucose, high levels of MR-proADM predict a slower progression of blood pressure and glycemia during long-term follow-up. Conversely, the cross-sectional associations with higher levels of MR-proADM and obesity were paralleled by a faster progression of obesity markers over time. These results may be important for assessment of long-term effects of therapies modulating levels of ADM.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Protein Precursors). 0 (proadrenomedullin). 148498-78-6 (Adrenomedullin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fHJH.0000000000001893
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ohlsson&issn=0263-6352&title=Journal+of+Hypertension&atitle=Midregional+proadrenomedullin+predicts+reduced+blood+pressure+and+glucose+elevation+over+time+despite+enhanced+progression+of+obesity+markers.&volume=37&issue=3&spage=590&epage=595&date=2019&doi=10.1097%2FHJH.0000000000001893&pmid=30540625&sid=OVID:medline
+
+<1837>
+Unique Identifier
+ 30536533
+Title
+ A correlational study between serum asymmetric dimethylarginine level and impaired glucose tolerance patients associated with obesity.
+Source
+ Journal of Cellular Physiology. 234(7):10640-10645, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang S; Xu Y; Peng WF; Cheng J; Li HH; Shen LS; Xia LL
+Author NameID
+ Huang, Shan; ORCID: https://orcid.org/0000-0003-1657-5266
+Authors Full Name
+ Huang, Shan; Xu, Yong; Peng, Wen-Fang; Cheng, Jie; Li, Hui-Hua; Shen, Li-Sha; Xia, Li-Li.
+Institution
+ Huang, Shan. Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Xu, Yong. Department of Nephrology, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu Province, China.
+ Peng, Wen-Fang. Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Cheng, Jie. Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Li, Hui-Hua. Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Shen, Li-Sha. Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+ Xia, Li-Li. Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
+MeSH Subject Headings
+ Aged
+ *Arginine/aa [Analogs & Derivatives]
+ Arginine/bl [Blood]
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ C-Reactive Protein/me [Metabolism]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ *Glucose Intolerance/bl [Blood]
+ Glucose Intolerance/co [Complications]
+ Glucose Intolerance/pa [Pathology]
+ Glucose Tolerance Test
+ Humans
+ Insulin Resistance/ge [Genetics]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+Keyword Heading
+ asymmetric dimethylarginine (ADMA)
+ glucose tolerance
+ insulin resistance (IR)
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Asymmetric dimethylarginine (ADMA) plays a vital role in the regulation of insulin sensitivity and has been shown as a potential marker for various disease, including type 2 diabetes mellitus (DM2). However, the correlation between ADMA and impaired glucose tolerance (IGT) and obesity has not been studied. A total of 195 subjects were involved in our study. The characteristics of the subjects in the study cohort were measured and analyzed. We found that the serum ADMA and C-reactive protein levels were significantly increased in IGT and diabetic patients, whereas the levels of lipoprotein A and adiponectin were decreased, especially in diabetic patients with obesity. The serum ADMA level was positively correlated to a homeostatic model assessment for insulin resistance, and multivariate regression analysis further indicated that ADMA was an independent factor for DM patients with obesity. Our study expands the understanding of the complicated relationship between obesity, insulin resistance, IGT, and ADMA. In addition, we demonstrated that the serum ADMA level could serve as a diagnositic biomarker of the early signs for IGT patients with obesity. Copyright © 2018 Wiley Periodicals, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (dimethylarginine). 9007-41-4 (C-Reactive Protein). 94ZLA3W45F (Arginine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fjcp.27743
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=0021-9541&title=Journal+of+Cellular+Physiology&atitle=A+correlational+study+between+serum+asymmetric+dimethylarginine+level+and+impaired+glucose+tolerance+patients+associated+with+obesity.&volume=234&issue=7&spage=10640&epage=10645&date=2019&doi=10.1002%2Fjcp.27743&pmid=30536533&sid=OVID:medline
+
+<1838>
+Unique Identifier
+ 30531919
+Title
+ ANT2 mediates hypoxia and inflammation in obesity.
+Source
+ Nature Reviews Endocrinology. 15(2):64, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Leake I
+Authors Full Name
+ Leake, Isobel.
+Institution
+ Leake, Isobel. Nature Reviews Endocrinology,. nrendo@nature.com.
+MeSH Subject Headings
+ *Adenine Nucleotide Translocator 2/me [Metabolism]
+ Adipocytes/cy [Cytology]
+ Adipocytes/ph [Physiology]
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Amino Acids/ph [Physiology]
+ Animals
+ Biomarkers/me [Metabolism]
+ Chromium/ph [Physiology]
+ Disease Models, Animal
+ Humans
+ *Hypoxia/me [Metabolism]
+ Hypoxia/pc [Prevention & Control]
+ Hypoxia-Inducible Factor 1, alpha Subunit/me [Metabolism]
+ *Inflammation/me [Metabolism]
+ Inflammation/pc [Prevention & Control]
+ Insulin Resistance/ph [Physiology]
+ Mice
+ Mice, Knockout
+ Nicotinic Acids/ph [Physiology]
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Oxygen Consumption/ph [Physiology]
+ Sensitivity and Specificity
+Registry Number/Name of Substance
+ 0 (Adenine Nucleotide Translocator 2). 0 (Amino Acids). 0 (Biomarkers). 0 (HIF1A protein, human). 0 (Hypoxia-Inducible Factor 1, alpha Subunit). 0 (Nicotinic Acids). 0 (glucose tolerance factor). 0R0008Q3JB (Chromium).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41574-018-0140-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Leake&issn=1759-5029&title=Nature+Reviews+Endocrinology&atitle=ANT2+mediates+hypoxia+and+inflammation+in+obesity.&volume=15&issue=2&spage=64&epage=&date=2019&doi=10.1038%2Fs41574-018-0140-z&pmid=30531919&sid=OVID:medline
+
+<1839>
+Unique Identifier
+ 30530906
+Title
+ Fatty pancreas in relation to insulin resistance and metabolic syndrome in children with obesity.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 32(1):19-26, 2019 Jan 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elhady M; Elazab AAAM; Bahagat KA; Abdallah NA; Ibrahim GE
+Author NameID
+ Elhady, Marwa; ORCID: https://orcid.org/0000-0002-7785-3736
+ Elazab, Amira Aly Ahmed Mahmoud; ORCID: https://orcid.org/0000-0002-5783-4781
+Authors Full Name
+ Elhady, Marwa; Elazab, Amira Aly Ahmed Mahmoud; Bahagat, Karima Abdelfattah; Abdallah, Naglaa Abdelmoneam; Ibrahim, Gamil El-Sayed.
+Institution
+ Elhady, Marwa. Department of Pediatrics, Faculty of Medicine (for girls), Al-Azhar University, Cairo, Egypt, Phone: 01120997660, E-mail:Marwaelhady93@yahoo.com.
+ Elazab, Amira Aly Ahmed Mahmoud. Radiodiagnosis Department, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt.
+ Bahagat, Karima Abdelfattah. Department of Pediatrics, Faculty of Medicine (for girls), Al-Azhar University, Cairo, Egypt.
+ Abdallah, Naglaa Abdelmoneam. Department of Pediatrics, Faculty of Medicine (for girls), Al-Azhar University, Cairo, Egypt.
+ Ibrahim, Gamil El-Sayed. Department of Flavor Chemistry, National Center Research, Giza, Egypt.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ Child
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ *Intra-Abdominal Fat/pp [Physiopathology]
+ Male
+ *Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pa [Pathology]
+ *Obesity/co [Complications]
+ *Pancreas/pp [Physiopathology]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ fatty pancreas
+ insulin resistance
+ metabolic syndrome
+ obesity
+ ultrasonography
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Ectopic visceral fat is a major risk factor for obesity complications including insulin resistance and metabolic syndrome. Ultrasonography is a simple bedside screening tool used for the assessment of ectopic visceral fat including fatty pancreas. This study investigates the association between insulin resistance, metabolic syndrome and fatty pancreas detected by ultrasound in children with obesity. Methods This case-control study included 50 prepubertal obese (body mass index [BMI] >=95th age- and sex-specific percentiles) and 30 lean children (BMI 5th-85th age- and sex-specific percentiles) as the control group. Clinical and laboratory parameters of metabolic syndrome including anthropometric indices of central obesity, blood pressure, fasting glucose and lipid profile were measured. Homeostasis model assessment-insulin resistance (HOMA-IR) was used to assess insulin resistance. Ultrasonographic assessment for pancreatic fat was done for all children. Results Fifty-eight percent of obese children had fatty pancreas. Obese children with fatty pancreas had a higher rate of metabolic syndrome (p=0.013) and insulin resistance than those with non-fatty pancreas (p=0.012). Regression analysis revealed that fatty pancreas is an independent predictor of metabolic syndrome and insulin resistance. Fatty pancreas increases the risk for metabolic syndrome (odds ratio [OR] 11.40; 95% confidence interval [CI]: 2.69-48.22) and insulin resistance (OR 7.85; 95% CI: 2.20-28.05) in children with obesity. Conclusions Obese children have higher pancreatic fat accumulation than lean children. Obese children with fatty pancreas are more susceptible to insulin resistance and metabolic syndrome.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fjpem-2018-0315
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elhady&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Fatty+pancreas+in+relation+to+insulin+resistance+and+metabolic+syndrome+in+children+with+obesity.&volume=32&issue=1&spage=19&epage=26&date=2019&doi=10.1515%2Fjpem-2018-0315&pmid=30530906&sid=OVID:medline
+
+<1840>
+Unique Identifier
+ 30530892
+Title
+ Adiponectin, leptin and high sensitivity C-reactive protein values in obese children - important markers for metabolic syndrome?.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 32(1):27-31, 2019 Jan 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Stroescu RF; Marginean O; Bizerea T; Gafencu M; Voicu A; Doros G
+Authors Full Name
+ Stroescu, Ramona F; Marginean, Otilia; Bizerea, Teofana; Gafencu, Mihai; Voicu, Adrian; Doros, Gabriela.
+Institution
+ Stroescu, Ramona F. Louis Turcanu Emergency Hospital for Children, Timisoara, Romania.
+ Stroescu, Ramona F. Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
+ Marginean, Otilia. Louis Turcanu Emergency Hospital for Children, Timisoara, Romania.
+ Marginean, Otilia. Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
+ Bizerea, Teofana. Louis Turcanu Emergency Hospital for Children, Timisoara, Romania.
+ Bizerea, Teofana. Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
+ Gafencu, Mihai. Louis Turcanu Emergency Hospital for Children, Timisoara, Romania.
+ Gafencu, Mihai. Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
+ Voicu, Adrian. Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
+ Doros, Gabriela. Louis Turcanu Emergency Hospital for Children, Timisoara, Romania.
+ Doros, Gabriela. Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ *C-Reactive Protein/an [Analysis]
+ Case-Control Studies
+ Child
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Leptin/bl [Blood]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/pa [Pathology]
+ *Obesity/co [Complications]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ adiponectin
+ high sensitivity C-reactive protein
+ leptin
+ pediatric population
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population. Methods A cross-sectional study was conducted over a period of 1 year, between July 2013 and June 2014, on 122 cases of obesity in children diagnosed at the Louis Turcanu Emergency Hospital for Children Timisoara, in the departments of Diabetes and Nutritional Diseases, Endocrinology and Cardiology. The patients were divided into two groups, according to the presence of MetS. Results MetS was present in 27% of obese children. The groups were homogenous with respect to age, sex and body mass index (BMI). Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively). Conclusions hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in pediatric population.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fjpem-2018-0378
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Stroescu&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Adiponectin%2C+leptin+and+high+sensitivity+C-reactive+protein+values+in+obese+children+-+important+markers+for+metabolic+syndrome%3F.&volume=32&issue=1&spage=27&epage=31&date=2019&doi=10.1515%2Fjpem-2018-0378&pmid=30530892&sid=OVID:medline
+
+<1841>
+Unique Identifier
+ 30528492
+Title
+ Haptoglobin levels are influenced by Hp1-Hp2 polymorphism, obesity, inflammation, and hypertension in type 2 diabetes mellitus.
+Source
+ Endocrinologia Diabetes Y Nutricion. 66(2):99-107, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rodrigues KF; Pietrani NT; Carvalho LML; Bosco AA; Sandrim VC; Ferreira CN; Gomes KB
+Authors Full Name
+ Rodrigues, Kathryna Fontana; Pietrani, Nathalia Teixeira; Carvalho, Laura Machado Lara; Bosco, Adriana Aparecida; Sandrim, Valeria Cristina; Ferreira, Claudia Natalia; Gomes, Karina Braga.
+Institution
+ Rodrigues, Kathryna Fontana. Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
+ Pietrani, Nathalia Teixeira. Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
+ Carvalho, Laura Machado Lara. Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
+ Bosco, Adriana Aparecida. Instituto de Ensino e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil.
+ Sandrim, Valeria Cristina. Instituto de Biociencias, Universidade Estadual Paulista Julio de Mesquita Filho, Botucatu, Sao Paulo, Brazil.
+ Ferreira, Claudia Natalia. Colegio Tecnico, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
+ Gomes, Karina Braga. Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: karinabgb@gmail.com.
+MeSH Subject Headings
+ Adult
+ Aged
+ Alleles
+ Biomarkers
+ Blood Glucose/an [Analysis]
+ C-Reactive Protein/an [Analysis]
+ Case-Control Studies
+ Comorbidity
+ Cross-Sectional Studies
+ Cytokines/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ Genotype
+ Glycated Hemoglobin/an [Analysis]
+ Haptoglobins/an [Analysis]
+ *Haptoglobins/ge [Genetics]
+ Humans
+ *Hypertension/bl [Blood]
+ Hypertension/ep [Epidemiology]
+ *Inflammation/bl [Blood]
+ Inflammation/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Polymorphism, Genetic
+ Waist Circumference
+ Waist-Hip Ratio
+Keyword Heading
+ Diabetes mellitus tipo 2
+ Haptoglobin
+ Haptoglobina
+ Inflamacion
+ Inflammation
+ Obesidad
+ Obesity
+ Polimorfismos
+ Polymorphisms
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Type 2 diabetes mellitus (T2DM) is an inflammatory condition associated to obesity and increased oxidative stress. Haptoglobin (Hp) is an acute phase reactant that scavenges extracorpuscular hemoglobin from circulation and prevents heme-iron oxidative damage.
+
+ OBJECTIVE: To assess the association between Hp levels and Hp1-Hp2 gene polymorphism and clinical and laboratory parameters in patients with T2DM.
+
+ METHODS: The study sample consisted of 102 T2DM patients and 62 controls. Hp plasma levels were measured using an ELISA assay, and Hp genotyping was performed using a specific two-step allelic polymerase chain reaction.
+
+ RESULTS: Hp levels were higher in T2DM patients as compared to controls (p=0.005). T2DM patients with high blood pressure had higher Hp levels than patients without this comorbidity (p=0.021). Obese T2DM patients had higher Hp levels as compared to obese controls (p=0.009) and to non-obese T2DM patients (p=0.003). The Hp1-Hp1 genotype was showed to be associated to T2DM according to additive (OR=3.038, 95% CI 1.127-8.192; p=0.036) and dominant model (OR=0.320, 95% CI 0.118-0.839; p=0.010), but Hp2 allele carriers contributed with higher Hp levels in T2DM as compared to controls. Waist circumference (p=0.002), BMI (p=0.001), and IL-6 (p=0.012), and hs-CRP (p=0.001) levels positively correlated with Hp levels in the T2DM group.
+
+ CONCLUSION: These results suggest that Hp levels are influenced by Hp1-Hp2 polymorphism, obesity, inflammatory status, and high blood pressure in T2DM. Copyright © 2018 SEEN y SED. Publicado por Elsevier Espana, S.L.U. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cytokines). 0 (Glycated Hemoglobin A). 0 (HP protein, human). 0 (Haptoglobins). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.endinu.2018.07.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rodrigues&issn=2530-0180&title=Endocrinologia+Diabetes+Y+Nutricion&atitle=Haptoglobin+levels+are+influenced+by+Hp1-Hp2+polymorphism%2C+obesity%2C+inflammation%2C+and+hypertension+in+type+2+diabetes+mellitus.&volume=66&issue=2&spage=99&epage=107&date=2019&doi=10.1016%2Fj.endinu.2018.07.008&pmid=30528492&sid=OVID:medline
+
+<1842>
+Unique Identifier
+ 30527835
+Title
+ Minimal difference in phenotype between adolescents and young adults with polycystic ovary syndrome.
+Source
+ Fertility & Sterility. 111(2):389-396, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zore T; Lizneva D; Brakta S; Walker W; Suturina L; Azziz R
+Authors Full Name
+ Zore, Temeka; Lizneva, Daria; Brakta, Soumia; Walker, Walidah; Suturina, Larisa; Azziz, Ricardo.
+Institution
+ Zore, Temeka. Department of Obstetrics and Gynecology, University of California, Los Angeles, California.
+ Lizneva, Daria. Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia; Medical Company IDK, Samara, Russian Federation; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation.
+ Brakta, Soumia. Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia.
+ Walker, Walidah. Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia.
+ Suturina, Larisa. Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation.
+ Azziz, Ricardo. Department of Obstetrics and Gynecology, University of California, Los Angeles, California; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation; Department of Health Policy, Management, and Behavior, School of Public Health, State University of New York, Albany, New York. Electronic address: ricardo.azziz@suny.edu.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Acne Vulgaris/bl [Blood]
+ Acne Vulgaris/di [Diagnosis]
+ Acne Vulgaris/ep [Epidemiology]
+ Adolescent
+ Age Factors
+ Alabama/ep [Epidemiology]
+ Amenorrhea/bl [Blood]
+ Amenorrhea/di [Diagnosis]
+ Amenorrhea/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cross-Sectional Studies
+ Dehydroepiandrosterone Sulfate/bl [Blood]
+ Female
+ Hirsutism/bl [Blood]
+ Hirsutism/di [Diagnosis]
+ Hirsutism/ep [Epidemiology]
+ Humans
+ Hyperandrogenism/bl [Blood]
+ Hyperandrogenism/di [Diagnosis]
+ Hyperandrogenism/ep [Epidemiology]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Oligomenorrhea/bl [Blood]
+ Oligomenorrhea/di [Diagnosis]
+ Oligomenorrhea/ep [Epidemiology]
+ Phenotype
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ *Polycystic Ovary Syndrome/ep [Epidemiology]
+ Prevalence
+ Risk Factors
+ Severity of Illness Index
+ Sex Hormone-Binding Globulin/an [Analysis]
+ Testosterone/bl [Blood]
+ Young Adult
+Keyword Heading
+ PCOS
+ adolescents
+ obesity
+ phenotypes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To test the hypothesis that the polycystic ovary syndrome (PCOS) phenotype, or its component features, is less severe in adolescents than in young adult patients, in a referred (clinical) population.
+
+ DESIGN: Cross-sectional study.
+
+ SETTING: Tertiary-care academic medical center.
+
+ PATIENT(S): Two hundred seventy-four adolescents and young adults aged 13.0-24.9 years with PCOS according to the National Institute of Health 1990 criteria. Patients were categorized as adolescents (AD: 13.0-18.9 years; n = 91) and young adults (YA: 19.0-24.9 years; n = 183). Adolescents were further categorized as early adolescents (Early-AD: 13.0-15.9 years; n = 31) and late adolescents (Late-AD: 16.0-18.9 years; n = 60).
+
+ INTERVENTION(S): History, physical examination, hormonal assays with the use of standardized protocols.
+
+ MAIN OUTCOME MEASURE(S): Unadjusted and adjusted odds ratios (ORs; adjusted for body mass index [BMI] when applicable) were calculated for biochemical hyperandrogenism (HA), hirsutism (HIR), acne, and degree of oligo/amenorrhea (OA). PCOS phenotypes were classified as HIR+HA+OA, HA+OA, and HIR+OA.
+
+ RESULT(S): Our analysis demonstrated minimal significant difference in the prevalence of the three PCOS phenotypes, or component features, between AD and YA patients. The risks for obesity were higher for YA versus AD, and the risk of acne was lower for YA versus AD. There was no significant difference between Early-AD and Late-AD. BMI-adjusted models did not significantly modify the main findings.
+
+ CONCLUSION(S): The present study suggests that the PCOS phenotype is established in early adolescence, remains constant into adulthood, and is not related to BMI. Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Sex Hormone-Binding Globulin). 3XMK78S47O (Testosterone). 57B09Q7FJR (Dehydroepiandrosterone Sulfate).
+Publication Type
+ Comparative Study. Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.fertnstert.2018.10.020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zore&issn=0015-0282&title=Fertility+%26+Sterility&atitle=Minimal+difference+in+phenotype+between+adolescents+and+young+adults+with+polycystic+ovary+syndrome.&volume=111&issue=2&spage=389&epage=396&date=2019&doi=10.1016%2Fj.fertnstert.2018.10.020&pmid=30527835&sid=OVID:medline
+
+<1843>
+Unique Identifier
+ 30523031
+Title
+ General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4/FF4 Cohort.
+Source
+ Diabetes Care. 42(2):240-247, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schlesinger S; Herder C; Kannenberg JM; Huth C; Carstensen-Kirberg M; Rathmann W; Bonhof GJ; Koenig W; Heier M; Peters A; Meisinger C; Roden M; Thorand B; Ziegler D
+Author NameID
+ Schlesinger, Sabrina; ORCID: https://orcid.org/0000-0003-4244-0832
+ Herder, Christian; ORCID: https://orcid.org/0000-0002-2050-093X
+ Huth, Cornelia; ORCID: https://orcid.org/0000-0003-2421-433X
+ Rathmann, Wolfgang; ORCID: https://orcid.org/0000-0001-7804-1740
+ Roden, Michael; ORCID: https://orcid.org/0000-0001-8200-6382
+ Ziegler, Dan; ORCID: https://orcid.org/0000-0001-8956-3552
+Authors Full Name
+ Schlesinger, Sabrina; Herder, Christian; Kannenberg, Julia M; Huth, Cornelia; Carstensen-Kirberg, Maren; Rathmann, Wolfgang; Bonhof, Gidon J; Koenig, Wolfgang; Heier, Margit; Peters, Annette; Meisinger, Christa; Roden, Michael; Thorand, Barbara; Ziegler, Dan.
+Institution
+ Schlesinger, Sabrina. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany sabrina.schlesinger@ddz.de.
+ Schlesinger, Sabrina. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Herder, Christian. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Herder, Christian. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Herder, Christian. Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Kannenberg, Julia M. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Kannenberg, Julia M. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Huth, Cornelia. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Huth, Cornelia. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Carstensen-Kirberg, Maren. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Carstensen-Kirberg, Maren. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Rathmann, Wolfgang. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Rathmann, Wolfgang. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Rathmann, Wolfgang. Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Bonhof, Gidon J. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Koenig, Wolfgang. Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Munich, Germany.
+ Koenig, Wolfgang. German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
+ Koenig, Wolfgang. Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
+ Heier, Margit. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Peters, Annette. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Peters, Annette. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Meisinger, Christa. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Meisinger, Christa. Chair of Epidemiology, Ludwig-Maximilians-Universitat Munchen am UNIKA-T Augsburg, Augsburg, Germany.
+ Roden, Michael. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Roden, Michael. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Roden, Michael. Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Thorand, Barbara. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Thorand, Barbara. Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
+ Ziegler, Dan. German Center for Diabetes Research, Munchen-Neuherberg, Germany.
+ Ziegler, Dan. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+ Ziegler, Dan. Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ *Biomarkers/me [Metabolism]
+ Cohort Studies
+ Diabetes Mellitus/ep [Epidemiology]
+ Diabetes Mellitus/me [Metabolism]
+ Female
+ Germany/ep [Epidemiology]
+ Humans
+ Incidence
+ *Inflammation/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ Obesity, Abdominal/co [Complications]
+ *Obesity, Abdominal/ep [Epidemiology]
+ Peripheral Nervous System Diseases/ep [Epidemiology]
+ Peripheral Nervous System Diseases/et [Etiology]
+ Peripheral Nervous System Diseases/me [Metabolism]
+ *Polyneuropathies/ep [Epidemiology]
+ Polyneuropathies/et [Etiology]
+ Polyneuropathies/me [Metabolism]
+ Prediabetic State/co [Complications]
+ Prediabetic State/ep [Epidemiology]
+ Prediabetic State/me [Metabolism]
+ Risk Factors
+ Waist Circumference
+Abstract
+ OBJECTIVE: To investigate the associations between different anthropometric measurements and development of distal sensorimotor polyneuropathy (DSPN) considering interaction effects with prediabetes/diabetes and to evaluate subclinical inflammation as a potential mediator.
+
+ RESEARCH DESIGN AND METHODS: This study was conducted among 513 participants from the Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort (aged 62-81 years). Anthropometry was measured at baseline. Incident DSPN was defined by neuropathic impairments using the Michigan Neuropathy Screening Instrument at baseline and follow-up. Associations between anthropometric measurements and DSPN were estimated by multivariable logistic regression. Potential differences by diabetes status were assessed using interaction terms. Mediation analysis was conducted to determine the mediation effect of subclinical inflammation in these associations.
+
+ RESULTS: After a mean follow-up of 6.5 years, 127 cases with incident DSPN were detected. Both general and abdominal obesity were associated with development of DSPN. The odds ratios (95% CI) of DSPN were 3.06 (1.57; 5.97) for overweight, 3.47 (1.72; 7.00) for obesity (reference: normal BMI), and 1.22 (1.07; 1.38) for 5-cm differences in waist circumference, respectively. Interaction analyses did not indicate any differences by diabetes status. Two chemokines (C-C motif chemokine ligand 7 [CCL7] and C-X-C motif chemokine ligand 10 [CXCL10]) and one neuron-specific marker (Delta/Notch-like epidermal growth factor-related receptor [DNER]) were identified as potential mediators, which explained a proportion of the total effect up to 11% per biomarker.
+
+ CONCLUSIONS: General and abdominal obesity were associated with incident DSPN among individuals with and without diabetes, and this association was partly mediated by inflammatory markers. However, further mechanisms and biomarkers should be investigated as additional mediators to explain the remainder of this association. Copyright © 2018 by the American Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2337%2fdc18-1842
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schlesinger&issn=0149-5992&title=Diabetes+Care&atitle=General+and+Abdominal+Obesity+and+Incident+Distal+Sensorimotor+Polyneuropathy%3A+Insights+Into+Inflammatory+Biomarkers+as+Potential+Mediators+in+the+KORA+F4%2FFF4+Cohort.&volume=42&issue=2&spage=240&epage=247&date=2019&doi=10.2337%2Fdc18-1842&pmid=30523031&sid=OVID:medline
+
+<1844>
+Unique Identifier
+ 30520243
+Title
+ Effect of baseline body mass index on glycemic control and weight change with exenatide monotherapy in Chinese drug-naive type 2 diabetic patients.
+Source
+ Journal Of Diabetes. 11(7):509-518, 2019 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Deng H; Lin S; Yang X; Lv J; Luo S; Zeng L; Weng J; Xu W
+Corporate Author
+ CONFIDENCE Group
+Authors Full Name
+ Deng, Hongrong; Lin, Shuo; Yang, Xubin; Lv, Jing; Luo, Sihui; Zeng, Longyi; Weng, Jianping; Xu, Wen.
+Institution
+ Deng, Hongrong. Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+ Lin, Shuo. Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+ Yang, Xubin. Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+ Lv, Jing. Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+ Luo, Sihui. Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+ Zeng, Longyi. Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+ Weng, Jianping. Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+ Xu, Wen. Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ *Body Weight/de [Drug Effects]
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ *Exenatide/tu [Therapeutic Use]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prognosis
+ Prospective Studies
+Keyword Heading
+ 2
+ body weight
+ exenatide
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The weight-reducing effect of exenatide has been proved, but too much weight loss in normal-weight patients may concern physicians. This study evaluated the effects of exenatide monotherapy on glycemic control and weight change in normal-weight, overweight, and obese patients with newly diagnosed type 2 diabetes (T2D).
+
+ METHODS: In this multicenter prospective study, 29 normal-weight, 54 overweight, and 27 obese newly diagnosed and drug-naive patients with T2D were treated with exenatide for 48 weeks. The primary efficacy endpoint was the effect of baseline body mass index (BMI) on glycemic control, measured as the change in HbA1c from baseline to Week 48 compared among different BMI groups. Other endpoints included comparisons of the effects of exenatide on fasting plasma glucose (FPG), postprandial plasma glucose (PPG), body weight, and other metabolic indices.
+
+ RESULTS: After 48-week treatment, the estimated mean changes in HbA1c in normal-weight, overweight, and obese patients were -1.9%, -1.8%, and -1.5%, respectively (P = 0.290 among groups after adjustment for baseline values). There were similar declines in FPG and 0.5- and 2-hour PPG among groups. There were non-significant trends from normal-weight to overweight to obese patients for increased weight reduction (decreases of 2.2, 3.9, and 4.0 kg, respectively; P = 0.104) and changes in waist circumference (decreases of 2.2, 3.2, and 5.6 cm, respectively; P = 0.078).
+
+ CONCLUSIONS: Baseline BMI had no effect on glycemic control, weight change, or other metabolic indices with exenatide monotherapy. Normal-weight patients with T2D would benefit from exenatide as much as overweight or obese patients on glucose control, without increased risk of excess weight loss. Copyright © 2018 The Authors. Journal of Diabetes published by John Wiley & Sons Australia, Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine.
+Other Abstract
+ Publisher
+ : , 2 : 2 , 48 , 29 , 54 , 27 (body mass index,BMI) BMI 48 (HbA1c) HbA1c : 48 , HbA1c 1.9% 1.8% 1.5%( HbA1c , P 0.290) 2 , ( 2.2 3.9 4.0 ,P = 0.104; 2.2 3.2 5.6 ,P = 0.078) : BMI 2 2 , .
+ Language: Chinese
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (hemoglobin A1c protein, human). 9P1872D4OL (Exenatide).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2f1753-0407.12883
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Deng&issn=1753-0407&title=Journal+Of+Diabetes&atitle=Effect+of+baseline+body+mass+index+on+glycemic+control+and+weight+change+with+exenatide+monotherapy+in+Chinese+drug-naive+type+2+diabetic+patients.&volume=11&issue=7&spage=509&epage=518&date=2019&doi=10.1111%2F1753-0407.12883&pmid=30520243&sid=OVID:medline
+
+<1845>
+Unique Identifier
+ 30516339
+Title
+ Independent links between plasma xanthine oxidoreductase activity and levels of adipokines.
+Source
+ Journal of Diabetes Investigation. 10(4):1059-1067, 2019 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Furuhashi M; Matsumoto M; Murase T; Nakamura T; Higashiura Y; Koyama M; Tanaka M; Moniwa N; Ohnishi H; Saitoh S; Shimamoto K; Miura T
+Author NameID
+ Furuhashi, Masato; ORCID: http://orcid.org/0000-0002-0145-3541
+Authors Full Name
+ Furuhashi, Masato; Matsumoto, Megumi; Murase, Takayo; Nakamura, Takashi; Higashiura, Yukimura; Koyama, Masayuki; Tanaka, Marenao; Moniwa, Norihito; Ohnishi, Hirofumi; Saitoh, Shigeyuki; Shimamoto, Kazuaki; Miura, Tetsuji.
+Institution
+ Furuhashi, Masato. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Matsumoto, Megumi. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Murase, Takayo. Sanwa Kagaku Kenkyusho Co., Ltd., Inabe, Japan.
+ Nakamura, Takashi. Sanwa Kagaku Kenkyusho Co., Ltd., Inabe, Japan.
+ Higashiura, Yukimura. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Koyama, Masayuki. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Koyama, Masayuki. Department of Public Health, School of Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Tanaka, Marenao. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Moniwa, Norihito. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Ohnishi, Hirofumi. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Ohnishi, Hirofumi. Department of Public Health, School of Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Saitoh, Shigeyuki. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+ Saitoh, Shigeyuki. Department of Nursing, Division of Medical and Behavioral Subjects, Sapporo Medical University School of Health Sciences, Sapporo, Japan.
+ Shimamoto, Kazuaki. Japan Health Care College, Sapporo, Japan.
+ Miura, Tetsuji. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Cohort Studies
+ *Fatty Acid-Binding Proteins/bl [Blood]
+ Female
+ *Fibroblast Growth Factors/bl [Blood]
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ *Xanthine Dehydrogenase/bl [Blood]
+Keyword Heading
+ Adipokine
+ Inslin resistance
+ Uric acid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS/INTRODUCTION: Xanthine oxidoreductase (XOR) is a rate-limiting enzyme that catalyzes uric acid formation in the purine metabolism, is involved in an increase in reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance.
+
+ MATERIALS AND METHODS: The association between plasma XOR activity, measured by using liquid chromatography and mass spectrometry, and levels of adipokines, including adiponectin, fatty acid-binding protein 4 (FABP4) and fibroblast growth factor 21 (FGF21), was investigated in 282 participants (male/female: 126/156) of the Tanno-Sobetsu Study who were not taking medication.
+
+ RESULTS: Women had lower plasma XOR activity than did men. Smoking habit was associated with increased activity. Plasma XOR activity was positively correlated with concentrations of FABP4 (r = 0.192, P < 0.001) and FGF21 (r = 0.208, P < 0.001), homeostasis model assessment of insulin resistance as an index of insulin resistance and uric acid, and was negatively correlated with adiponectin level (r = -0.243, P = 0.001). Multivariate regression analyses showed that levels of adiponectin, FABP4 and FGF21 were independent determinants of plasma XOR activity after adjusting age, sex, uric acid and homeostasis model assessment of insulin resistance. With additional adjustment of smoking habit, the level of FABP4, but not that of adiponectin or FGF21, remained as an independent predictor of plasma XOR activity.
+
+ CONCLUSIONS: Plasma XOR activity was independently associated with levels of adipokines in a general population of individuals not taking medication. Copyright © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (FABP4 protein, human). 0 (Fatty Acid-Binding Proteins). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors). EC 1-17-1-4 (Xanthine Dehydrogenase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fjdi.12982
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Furuhashi&issn=2040-1116&title=Journal+of+Diabetes+Investigation&atitle=Independent+links+between+plasma+xanthine+oxidoreductase+activity+and+levels+of+adipokines.&volume=10&issue=4&spage=1059&epage=1067&date=2019&doi=10.1111%2Fjdi.12982&pmid=30516339&sid=OVID:medline
+
+<1846>
+Unique Identifier
+ 30513433
+Title
+ Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia.
+Source
+ Journal of Nutritional Biochemistry. 64:162-169, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Huang F; Del-Rio-Navarro BE; Leija-Martinez J; Torres-Alcantara S; Ruiz-Bedolla E; Hernandez-Cadena L; Barraza-Villarreal A; Romero-Nava R; Sanchez-Munoz F; Villafana S; Marchat LA; Hong E
+Authors Full Name
+ Huang, Fengyang; Del-Rio-Navarro, Blanca Estela; Leija-Martinez, Jose; Torres-Alcantara, Saul; Ruiz-Bedolla, Eliseo; Hernandez-Cadena, Leticia; Barraza-Villarreal, Albino; Romero-Nava, Rodrigo; Sanchez-Munoz, Fausto; Villafana, Santiago; Marchat, Laurence A; Hong, Enrique.
+Institution
+ Huang, Fengyang. Research Laboratory of Pharmacology, Hospital Infantil de Mexico Federico Gomez (HIMFG), Mexico.
+ Del-Rio-Navarro, Blanca Estela. Department of Allergy, HIMFG, Mexico City, Mexico. Electronic address: blancadelrionavarro@gmail.com.
+ Leija-Martinez, Jose. Department of Allergy, HIMFG, Mexico City, Mexico.
+ Torres-Alcantara, Saul. Research Laboratory of Pharmacology, Hospital Infantil de Mexico Federico Gomez (HIMFG), Mexico.
+ Ruiz-Bedolla, Eliseo. Laboratory Center, HIMFG, Mexico City, Mexico.
+ Hernandez-Cadena, Leticia. Department of Environmental Health, Population Health Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
+ Barraza-Villarreal, Albino. Department of Environmental Health, Population Health Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
+ Romero-Nava, Rodrigo. Research Laboratory of Pharmacology, Hospital Infantil de Mexico Federico Gomez (HIMFG), Mexico; Laboratory of Pharmacology, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico.
+ Sanchez-Munoz, Fausto. Departamento de Inmunologia, Instituto Nacional de Cardiologia "Ignacio Chavez", Mexico City, Mexico.
+ Villafana, Santiago. Superior School of Medicine, National Polytechnic Institute, Mexico City, Mexico.
+ Marchat, Laurence A. Seccion de Estudios de Posgrado e Investigacion, Escuela Nacional de Medicina y Homeopatia del Instituto Politecnico Nacional, Mexico City, Mexico.
+ Hong, Enrique. Department of Pharmacobiology, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico City, Mexico.
+MeSH Subject Headings
+ *Adipokines/bl [Blood]
+ Adolescent
+ Biomarkers/bl [Blood]
+ Child
+ Dietary Supplements
+ Double-Blind Method
+ Endothelium, Vascular/me [Metabolism]
+ Endothelium, Vascular/pp [Physiopathology]
+ *Fatty Acids, Omega-3/tu [Therapeutic Use]
+ Healthy Lifestyle
+ Humans
+ *Hypertriglyceridemia/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Regression Analysis
+ Treatment Outcome
+ Triglycerides/bl [Blood]
+Keyword Heading
+ ADMA
+ Adipokines
+ Lifestyle intervention
+ Obese adolescents
+ Omega-3
+ sE
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents. Copyright © 2018 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Fatty Acids, Omega-3). 0 (Triglycerides).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.jnutbio.2018.10.012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Huang&issn=0955-2863&title=Journal+of+Nutritional+Biochemistry&atitle=Effect+of+omega-3+fatty+acids+supplementation+combined+with+lifestyle+intervention+on+adipokines+and+biomarkers+of+endothelial+dysfunction+in+obese+adolescents+with+hypertriglyceridemia.&volume=64&issue=&spage=162&epage=169&date=2019&doi=10.1016%2Fj.jnutbio.2018.10.012&pmid=30513433&sid=OVID:medline
+
+<1847>
+Unique Identifier
+ 30508521
+Title
+ Circulating Gas6 is associated with reduced human carotid atherosclerotic plaque burden in high risk cardiac patients.
+Source
+ Clinical Biochemistry. 64:6-11, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Holden RM; Hetu MF; Li TY; Ward EC; Couture LE; Herr JE; Christilaw E; Adams MA; Johri AM
+Authors Full Name
+ Holden, Rachel M; Hetu, Marie-France; Li, Terry Y; Ward, Emilie C; Couture, Laura E; Herr, Julia E; Christilaw, Erin; Adams, Michael A; Johri, Amer M.
+Institution
+ Holden, Rachel M. Department of Medicine, Queen's University, Kingston, Ontario, Canada; Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada.
+ Hetu, Marie-France. Department of Medicine, Division of Cardiology, Cardiovascular Imaging Network at Queen's, Queen's University, Kingston, Ontario, Canada.
+ Li, Terry Y. Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada.
+ Ward, Emilie C. Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada.
+ Couture, Laura E. Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada.
+ Herr, Julia E. Department of Medicine, Division of Cardiology, Cardiovascular Imaging Network at Queen's, Queen's University, Kingston, Ontario, Canada.
+ Christilaw, Erin. Department of Medicine, Queen's University, Kingston, Ontario, Canada.
+ Adams, Michael A. Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada.
+ Johri, Amer M. Department of Medicine, Division of Cardiology, Cardiovascular Imaging Network at Queen's, Queen's University, Kingston, Ontario, Canada; Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada. Electronic address: amerschedule@gmail.com.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/co [Complications]
+ *Carotid Artery Diseases/bl [Blood]
+ Carotid Artery Diseases/dg [Diagnostic Imaging]
+ *Carotid Artery Diseases/pa [Pathology]
+ Carotid Intima-Media Thickness
+ Coronary Angiography
+ Cross-Sectional Studies
+ Diabetes Complications
+ Dyslipidemias/co [Complications]
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ Humans
+ *Intercellular Signaling Peptides and Proteins/bl [Blood]
+ Kidney Function Tests
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Plaque, Atherosclerotic/dg [Diagnostic Imaging]
+ *Plaque, Atherosclerotic/pa [Pathology]
+ Risk Factors
+ Sex Factors
+ Smoking
+Keyword Heading
+ Carotid
+ Coronary artery disease
+ Gas6
+ Plaque
+ Ultrasound
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Pre-clinical studies suggest that growth arrest-specific protein 6 (Gas6), a member of the vitamin K dependent family of proteins, is implicated in atherosclerosis. A role for Gas6 in stabilizing atherosclerotic plaque has been suggested. Our aim was to determine the association between Gas6 and measures of carotid artery atherosclerosis in humans undergoing elective coronary angiography. Secondary aims were to determine the association between Gas6 and sex, diabetes, and obesity.
+
+ METHODS: In 204 outpatients referred for coronary angiography, EDTA plasma was collected and a focused carotid ultrasound performed. Degree of angiographic coronary artery disease was scored. Carotid intima media thickness as well as maximum plaque height, plaque area, and grayscale median were measured by vascular sonography. Gas6 was assessed by enzyme-linked immunosorbent assay.
+
+ RESULTS: We found that Gas6 concentrations were lower in males and were associated with diabetes, obesity, and lower kidney function. After adjustment for age, sex, kidney function, BMI and traditional cardiac risk factors; diabetes was associated with higher levels of Gas6, whilst there was a significant inverse relationship between Gas6 and total plaque area. Gas6 was inversely associated with maximum plaque height and total plaque area in adjusted multi-variable models.
+
+ CONCLUSIONS: We observed higher levels of Gas6 in participantswith adverse cardiovascular risk profiles (e.g. diabetes, obesity) yet Gas6 was independently associated with reduced plaque height and total plaque area. These findings suggest that Gas6 may play a role in human atherosclerotic plaque remodeling. Copyright © 2018 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Intercellular Signaling Peptides and Proteins). 0 (growth arrest-specific protein 6).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.clinbiochem.2018.11.018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Holden&issn=0009-9120&title=Clinical+Biochemistry&atitle=Circulating+Gas6+is+associated+with+reduced+human+carotid+atherosclerotic+plaque+burden+in+high+risk+cardiac+patients.&volume=64&issue=&spage=6&epage=11&date=2019&doi=10.1016%2Fj.clinbiochem.2018.11.018&pmid=30508521&sid=OVID:medline
+
+<1848>
+Unique Identifier
+ 30503849
+Title
+ Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men.
+Source
+ Physiology & Behavior. 205:15-21, 2019 06 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kolahdouzi S; Baghadam M; Kani-Golzar FA; Saeidi A; Jabbour G; Ayadi A; De Sousa M; Zouita A; Abderrahmane AB; Zouhal H
+Authors Full Name
+ Kolahdouzi, Sarkawt; Baghadam, Mohammad; Kani-Golzar, Farhad Ahmadi; Saeidi, Ayoub; Jabbour, Georges; Ayadi, Amani; De Sousa, Maysa; Zouita, Amira; Abderrahmane, Abderraouf Ben; Zouhal, Hassane.
+Institution
+ Kolahdouzi, Sarkawt. Department of Exercise Physiology, Exercise Biochemistry Division, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Baghadam, Mohammad. Department of Physical Education and Sport Science, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran.
+ Kani-Golzar, Farhad Ahmadi. Department of Exercise Physiology, Exercise Biochemistry Division, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Saeidi, Ayoub. Department of Exercise Physiology, Exercise Biochemistry Division, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
+ Jabbour, Georges. Sport Science Program, College of Arts and Sciences, Qatar University, P.O. Box 2713, Doha, Qatar.
+ Ayadi, Amani. Department of Physical Education and Sport Science, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran.
+ De Sousa, Maysa. Higher Institute of Sport and Physical Education of Ksar Said, Tunis, Tunisia.
+ Zouita, Amira. Laboratory of Medical Investigation, LIM-18, Endocrinology Division, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
+ Abderrahmane, Abderraouf Ben. Laboratory of Biomonitoring of the Environment, Faculty of Science of Bizerte, University of Carthage, Tunisia.
+ Zouhal, Hassane. Univ Rennes, M2S (Laboratoire Mouvement, Sport, Sante) - EA 1274, F-35000 Rennes, France. Electronic address: hal@univ-rennes2.fr.
+MeSH Subject Headings
+ Adult
+ *Apelin/bl [Blood]
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Body Composition
+ Body Mass Index
+ *C-Reactive Protein/me [Metabolism]
+ *Chemokines/bl [Blood]
+ *Circuit-Based Exercise/sn [Statistics & Numerical Data]
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ *Lipids/bl [Blood]
+ Male
+ *Obesity/me [Metabolism]
+ Obesity/th [Therapy]
+ *Resistance Training/sn [Statistics & Numerical Data]
+ *Serum Amyloid A Protein/me [Metabolism]
+ Young Adult
+Keyword Heading
+ Adipokine
+ Exercise training
+ Inflammation
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Circuit resistance training (CRT) is a time-efficient exercise modality for improving skeletal muscle and cardiovascular fitness. But the beneficial role of CRT in obese individuals is still not well understood. This study explores the reducing effects of progressive CRT on inflammatory biomarkers and cardiometabolic risk factors in obese young men.
+
+ METHODS: Thirty obese men (Body mass index (BMI): 30.67+/-3.06; age: 23+/-3.2years) were divided into CRT and control groups. The CRT was performed for eight-weeks (3 times/week, 65-85% of 1 repetition maximum). Fasting blood samples were taken pre and post intervention for analyzing apelin, chemerin, serum amyloid A (SAA), C reactive protein concentrations (CRP), lipid profile, and insulin resistance index. The data were assessed by two-way repeated measures ANOVA.
+
+ RESULTS: Body mass, BMI and waist to hip ratio (WHR) were significantly decreased after training intervention (P<.05). Compared to the control group, the plasma concentrations of Chemrin (P=.038), SAA (P=.004), insulin (P<.001), insulin resistance index (P<.001), total cholesterol (P=.033), triglyceride (P<.001), and low-density lipoprotein (P=.039), were significantly mitigated in the CRT group, but high-density lipoprotein plasma levels increased in the CRT group compared to that of the control group (P=.035). There was no significant difference between two groups in apelin and CRP (P>.05). Moreover, insulin resistance was positively correlated with apelin (r=0.56) and chemerin (r=0.51). Also, chemerin had a positive correlation with SAA (r=0.49), and WHR (r=0.54).
+
+ CONCLUSION: CRT caused an improvement in inflammation and cardiometabolic risk factors in young obese men, and this improvement was accompanied by decreased insulin resistance. Copyright © 2018. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Apelin). 0 (Biomarkers). 0 (Chemokines). 0 (Lipids). 0 (RARRES2 protein, human). 0 (Serum Amyloid A Protein). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Controlled Clinical Trial. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.physbeh.2018.11.033
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kolahdouzi&issn=0031-9384&title=Physiology+%26+Behavior&atitle=Progressive+circuit+resistance+training+improves+inflammatory+biomarkers+and+insulin+resistance+in+obese+men.&volume=205&issue=&spage=15&epage=21&date=2019&doi=10.1016%2Fj.physbeh.2018.11.033&pmid=30503849&sid=OVID:medline
+
+<1849>
+Unique Identifier
+ 30502048
+Title
+ Relation of Neutrophil to Lymphocyte Ratio to Risk of Incident Atrial Fibrillation.
+Source
+ American Journal of Cardiology. 123(3):396-401, 2019 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Berkovitch A; Younis A; Grossman Y; Segev S; Kivity S; Sidi Y; Beinart R; Goldenberg I; Maor E
+Authors Full Name
+ Berkovitch, Anat; Younis, Arwa; Grossman, Yoni; Segev, Shlomo; Kivity, Shaye; Sidi, Yechezkel; Beinart, Roy; Goldenberg, Ilan; Maor, Elad.
+Institution
+ Berkovitch, Anat. Leviev Heart Center, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
+ Younis, Arwa. Leviev Heart Center, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
+ Grossman, Yoni. Leviev Heart Center, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
+ Segev, Shlomo. Institute for Medical Screening, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
+ Kivity, Shaye. Department of Internal Medicine C, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Pinchas Borenstein Talpiot Medical Leadership Program, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
+ Sidi, Yechezkel. Department of Internal Medicine C, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
+ Beinart, Roy. Leviev Heart Center, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Limburg, The Netherlands.
+ Goldenberg, Ilan. The University of Rochester Medical Center, Rochester, New York.
+ Maor, Elad. Leviev Heart Center, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Pinchas Borenstein Talpiot Medical Leadership Program, The Chaim Sheba Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: Elad.Maor@sheba.health.gov.il.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Age Factors
+ *Atrial Fibrillation/bl [Blood]
+ *Atrial Fibrillation/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ Female
+ Follow-Up Studies
+ Humans
+ Hypertension/ep [Epidemiology]
+ Israel/ep [Epidemiology]
+ *Lymphocyte Count
+ Male
+ Middle Aged
+ Myocardial Ischemia/ep [Epidemiology]
+ *Neutrophils/me [Metabolism]
+ Obesity/ep [Epidemiology]
+ Risk Assessment
+ Sex Factors
+Abstract
+ Clinical and experimental data support a critical role for inflammation in cardiovascular disease. The purpose of the current study was to examine the relation between an inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), and incident atrial fibrillation (AF) in asymptomatic adults. We investigated 21,118 self-referred men and women who were annually screened in a tertiary medical center. All subjects were free of AF at baseline and had their serum NLR calculated at the first annual visit. Subjects were divided into 2 groups based on their baseline NLR: Low (<2.83; n = 17,524) and high (>=2.83; n = 3,594; Upper Sextile). The primary endpoint was new onset AF during follow-up. Mean age of study population was 48 +/- 10 years and 72% were men. A total of 563 (2.7%) incident events occurred during an average follow-up of 7.5 +/- 5 years. Unadjusted Cox regression analysis demonstrated that each 1 unit increase in NLR was associated with a significant 14% increase in risk of occurrence of a first AF event (95% confidence interval 1.06 to 1.23, p < 0.001) and 20% increased risk of death. Kaplan-Meier's survival analysis showed that the cumulative probability of incident AF was significantly higher among subjects with high NLR compared with low NLR group (p=0.006). Interaction analysis with adjustment to clinical parameters showed that NLR-related risk was age-dependent, such that in the younger age-group (< =50 years) high NLR group had two folds increased risk for AF event compared with low NLR group (95% confidence interval 1.08 to 3.51; p=0.027) whereas among older subjects the rate of events was similar between both NLR groups (p=NS; p for interaction=0.024). In conclusion, our findings suggest that high NLR is associated with increased risk of new onset AF. This finding is more pronounced among young adults. Copyright © 2018. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.amjcard.2018.10.036
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Berkovitch&issn=0002-9149&title=American+Journal+of+Cardiology&atitle=Relation+of+Neutrophil+to+Lymphocyte+Ratio+to+Risk+of+Incident+Atrial+Fibrillation.&volume=123&issue=3&spage=396&epage=401&date=2019&doi=10.1016%2Fj.amjcard.2018.10.036&pmid=30502048&sid=OVID:medline
+
+<1850>
+Unique Identifier
+ 30500981
+Title
+ Hispanic ethnicity as a moderator of the effects of aerobic and resistance exercise in survivors of breast cancer.
+Source
+ Cancer. 125(6):910-920, 2019 03 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dieli-Conwright CM; Sweeney FC; Courneya KS; Tripathy D; Sami N; Lee K; Buchanan TA; Spicer D; Bernstein L; Mortimer JE; Demark-Wahnefried W
+Author NameID
+ Demark-Wahnefried, Wendy; ORCID: https://orcid.org/0000-0001-5241-932X
+Authors Full Name
+ Dieli-Conwright, Christina M; Sweeney, Frank C; Courneya, Kerry S; Tripathy, Debu; Sami, Nathalie; Lee, Kyuwan; Buchanan, Thomas A; Spicer, Darcy; Bernstein, Leslie; Mortimer, Joanne E; Demark-Wahnefried, Wendy.
+Institution
+ Dieli-Conwright, Christina M. Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California.
+ Dieli-Conwright, Christina M. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
+ Sweeney, Frank C. Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California.
+ Courneya, Kerry S. Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.
+ Tripathy, Debu. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
+ Sami, Nathalie. Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California.
+ Lee, Kyuwan. Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California.
+ Buchanan, Thomas A. Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California.
+ Spicer, Darcy. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
+ Bernstein, Leslie. Division of Biomarkers of Early Detection and Prevention, Beckman Research Institute, City of Hope, Duarte, California.
+ Mortimer, Joanne E. Division of Medical Oncology and Experimental Therapeutics, City of Hope, Duarte, California.
+ Demark-Wahnefried, Wendy. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Breast Neoplasms/bl [Blood]
+ Breast Neoplasms/eh [Ethnology]
+ *Breast Neoplasms/rh [Rehabilitation]
+ Cancer Survivors
+ Exercise
+ Female
+ *Hispanic or Latino/sn [Statistics & Numerical Data]
+ Humans
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ Obesity/rh [Rehabilitation]
+ *Resistance Training/mt [Methods]
+ Sarcopenia/bl [Blood]
+ Sarcopenia/et [Etiology]
+ *Sarcopenia/rh [Rehabilitation]
+ Treatment Outcome
+Keyword Heading
+ Hispanic breast cancer survivors
+ exercise
+ metabolic syndrome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Metabolic syndrome (MSY) is associated with an increased risk of cardiovascular disease, type 2 diabetes, and recurrence in breast cancer survivors (BCS). MSY is 1.5 times more common in Hispanic women compared with non-Hispanic women. Although exercise mitigates MSY in BCS, to the best of the authors' knowledge, few studies to date have focused on minorities. This secondary analysis examined ethnicity as a moderator of the effects of a 16-week aerobic and resistance exercise intervention on MSY, sarcopenic obesity, and serum biomarkers in BCS.
+
+ METHODS: A total of 100 eligible BCS were randomized to exercise (50 BCS) or usual care (50 BCS). The exercise intervention promoted moderate to vigorous aerobic and resistance exercise 3 times a week for 16 weeks. MSY z scores, sarcopenic obesity, and serum biomarkers were measured at baseline, after the intervention, and at the 28-week follow-up (exercise group only). Linear mixed models adjusted for baseline values of the outcome, age, disease stage, adjuvant treatment, and recent physical activity were used to evaluate effect modification by ethnicity.
+
+ RESULTS: The study sample was 57% Hispanic BCS (HBCS) and 43% non-Hispanic BCS (NHBCS). HBCS were younger, of greater adiposity, and had been diagnosed with more advanced cancers compared with NHBCS (P<.001). Ethnicity was found to moderate the mean differences in exercise training on triglycerides (-36.4 mg/dL; 95% confidence interval [95% CI],-64.1 to -18.8 mg/dL), glucose (-8.6 mg/dL; 95% CI, -19.1 to -3.0 mg/dL), and C-reactive protein (-3.3 mg/L; 95% CI, -7.3 to -0.9 mg/L).
+
+ CONCLUSIONS: HBCS appear to have poorer metabolic profiles and therefore may derive relatively larger metabolic changes from exercise compared with NHBCS. Clinical exercise interventions may attenuate existing health disparities across diverse groups of BCS. Copyright © 2018 American Cancer Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fcncr.31879
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dieli-Conwright&issn=0008-543X&title=Cancer&atitle=Hispanic+ethnicity+as+a+moderator+of+the+effects+of+aerobic+and+resistance+exercise+in+survivors+of+breast+cancer.&volume=125&issue=6&spage=910&epage=920&date=2019&doi=10.1002%2Fcncr.31879&pmid=30500981&sid=OVID:medline
+
+<1851>
+Unique Identifier
+ 30496542
+Title
+ Sex Hormone-Binding Globulin Expression Correlates With Acetyl-Coenzyme A Carboxylase and Triglyceride Content in Human Liver.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 104(5):1500-1507, 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Saez-Lopez C; Salcedo-Allende MT; Hernandez C; Simo-Servat O; Simo R; Selva DM
+Authors Full Name
+ Saez-Lopez, Cristina; Salcedo-Allende, Maria Teresa; Hernandez, Cristina; Simo-Servat, Olga; Simo, Rafael; Selva, David M.
+Institution
+ Saez-Lopez, Cristina. Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autonoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain.
+ Salcedo-Allende, Maria Teresa. Human Pathology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
+ Hernandez, Cristina. Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autonoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain.
+ Simo-Servat, Olga. Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autonoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain.
+ Simo, Rafael. Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autonoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain.
+ Selva, David M. Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autonoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain.
+MeSH Subject Headings
+ Acetyl-CoA Carboxylase/ge [Genetics]
+ *Acetyl-CoA Carboxylase/me [Metabolism]
+ Adult
+ Biomarkers/an [Analysis]
+ Case-Control Studies
+ *Fatty Liver/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Hep G2 Cells
+ Humans
+ Lipogenesis
+ Male
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/pp [Physiopathology]
+ *Obesity/co [Complications]
+ Prognosis
+ Sex Hormone-Binding Globulin/ge [Genetics]
+ *Sex Hormone-Binding Globulin/me [Metabolism]
+ *Triglycerides/bl [Blood]
+Abstract
+ CONTEXT: There is emerging evidence that SHBG is substantially reduced in chronic metabolic diseases, including obesity and nonalcoholic fatty liver disease (NAFLD). We have recently reported, through use of in vitro (HepG2 cells) and in vivo (SHBG-C57BL/ksJ-db/db mice) models, that SHBG could play a role in arresting the progression of NAFLD by downregulating lipogenesis.
+
+ OBJECTIVE: The main aim of this study was to investigate the mechanisms by which SHBG prevents hepatic lipogenesis by examining the relationship between SHBG and a key lipogenic enzyme, such as acetyl-coenzyme A carboxylase (ACC) in the liver of obese persons.
+
+ PARTICIPANTS AND METHODS: SHBG and ACC mRNA levels, as well as triglyceride content, were analyzed in 41 liver samples from nondiabetic obese patients with NAFLD who had undergone bariatric surgery. We also studied the effect of SHBG overexpression in HepG2 cells cultured under high-glucose conditions.
+
+ RESULTS: SHBG mRNA and protein levels were lower in patients with metabolic syndrome than in those without metabolic syndrome; however, these differences were significant only for mRNA level. SHBG mRNA levels correlated positively with SHBG protein levels and hepatic triglyceride content. In addition, SHBG mRNA and protein levels correlated negatively with ACC mRNA levels and triglyceride content. Furthermore, SHBG overexpression abrogated the increase in ACC expression induced by high-glucose treatment in HepG2 cells.
+
+ CONCLUSIONS: Our findings suggest that SHBG plays a role in regulating hepatic lipogenesis by reducing ACC levels. These results suggest a strategy for the treatment of NAFLD. Copyright © 2019 Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (SHBG protein, human). 0 (Sex Hormone-Binding Globulin). 0 (Triglycerides). EC 6-4-1-2 (ACACA protein, human). EC 6-4-1-2 (Acetyl-CoA Carboxylase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1210%2fjc.2018-00740
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Saez-Lopez&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Sex+Hormone-Binding+Globulin+Expression+Correlates+With+Acetyl-Coenzyme+A+Carboxylase+and+Triglyceride+Content+in+Human+Liver.&volume=104&issue=5&spage=1500&epage=1507&date=2019&doi=10.1210%2Fjc.2018-00740&pmid=30496542&sid=OVID:medline
+
+<1852>
+Unique Identifier
+ 30488797
+Title
+ Vascular Dysfunction and Insulin Resistance in Aging. [Review]
+Source
+ Current Vascular Pharmacology. 17(5):465-475, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baranowska-Bik A; Bik W
+Authors Full Name
+ Baranowska-Bik, Agnieszka; Bik, Wojciech.
+Institution
+ Baranowska-Bik, Agnieszka. Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
+ Bik, Wojciech. Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
+MeSH Subject Headings
+ Adiposity
+ Age Factors
+ *Aging/bl [Blood]
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/ep [Epidemiology]
+ Inflammation/pp [Physiopathology]
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Risk Factors
+ Vascular Diseases/bl [Blood]
+ Vascular Diseases/ep [Epidemiology]
+ *Vascular Diseases/pp [Physiopathology]
+Keyword Heading
+ DM
+ Insulin
+ aging
+ cardiovascular disease
+ insulin resistance
+ vascular dysfunction.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Insulin was discovered in 1922 by Banting and Best. Since that time, extensive research on the mechanisms of insulin activity and action has continued. Currently, it is known that the role of insulin is much greater than simply regulating carbohydrate metabolism. Insulin in physiological concentration is also necessary to maintain normal vascular function. Insulin resistance is defined as a pathological condition characterized by reduced sensitivity of skeletal muscles, liver, and adipose tissue, to insulin and its downstream metabolic effects under normal serum glucose concentrations. There are also selective forms of insulin resistance with unique features, including vascular insulin resistance. Insulin resistance, both classical and vascular, contributes to vascular impairment resulting in increased risk of cardiovascular disease. Furthermore, in the elderly population, additional factors including redistribution of fat concentrations, low-grade inflammation, and decreased self-repair capacity [or cell senescence] amplify the vascular abnormalities related to insulin resistance. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2174%2f1570161117666181129113611
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baranowska-Bik&issn=1570-1611&title=Current+Vascular+Pharmacology&atitle=Vascular+Dysfunction+and+Insulin+Resistance+in+Aging.&volume=17&issue=5&spage=465&epage=475&date=2019&doi=10.2174%2F1570161117666181129113611&pmid=30488797&sid=OVID:medline
+
+<1853>
+Unique Identifier
+ 30488128
+Title
+ Differences in peri-operative serum inflammatory markers between normoponderal and obese patients undergoing large joint replacement for osteoarthritis-a descriptive study.
+Source
+ International Orthopaedics. 43(7):1735-1740, 2019 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tilinca MC; Zazgyva A; Pop TS
+Authors Full Name
+ Tilinca, Mariana Cornelia; Zazgyva, Ancuta; Pop, Tudor Sorin.
+Institution
+ Tilinca, Mariana Cornelia. Department of Cell and Molecular Biology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gheorghe Marinescu 38, 540139, Targu Mures, Romania.
+ Zazgyva, Ancuta. Department of Cell and Molecular Biology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gheorghe Marinescu 38, 540139, Targu Mures, Romania. zazgyvaa@yahoo.com.
+ Pop, Tudor Sorin. Department of Orthopaedics and Traumatology 1, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gheorghe Marinescu 38, 540139, Targu Mures, Romania.
+MeSH Subject Headings
+ Aged
+ Arthroplasty, Replacement, Hip
+ Arthroplasty, Replacement, Knee
+ Biomarkers/bl [Blood]
+ Body Weight
+ C-Reactive Protein/an [Analysis]
+ Female
+ Fibrinogen/an [Analysis]
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/co [Complications]
+ Interleukin-6/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Osteoarthritis, Hip/bl [Blood]
+ Osteoarthritis, Hip/co [Complications]
+ Osteoarthritis, Hip/su [Surgery]
+ *Osteoarthritis, Knee/bl [Blood]
+ Osteoarthritis, Knee/co [Complications]
+ Osteoarthritis, Knee/su [Surgery]
+ Perioperative Period
+ Treatment Outcome
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ IL-6
+ Inflammatory markers
+ Joint replacement
+ Obesity
+ TNF-alpha
+ hsCRP
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: The occurrence, evolution and treatment outcome of osteoarthritis are influenced by a series of factors, including obesity. Assessing how chronic inflammation present in obesity changes the values of peri-operative biological tests could facilitate a clearer interpretation of laboratory examinations for the proper management of possible complications.
+
+ METHODS: This descriptive study compared biological and clinical factors during the peri-operative period in patients undergoing total hip/knee replacement, in order to identify the special characteristics of the inflammatory status in obese compared to normal weight patients. In the two groups (71 normoponderal, 74 obese), serum levels of fibrinogen, high-sensitivity C-reactive protein (hsCRP), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were determined 24 hours pre- and post-operatively.
+
+ RESULTS: Our results found significant post-operative increases in serum levels of IL-6 and hsCRP in both groups (p = 0.0001), with inter-group differences in pre-operative hsCRP (p = 0.02) and post-operative IL-6 levels (p = 0.013). Interestingly, TNF-alpha levels were much higher in the obese pre-operatively than post-operatively (p = 0.002) and higher than the normoponderals (p = 0.003), decreasing to levels similar to those of the normal weight patients on day two.
+
+ CONCLUSIONS: Because of its important clinical implications, an appropriate comprehension of the peri-operative changes in a patient's inflammatory status has the potential to influence therapeutic attitude. We failed to observe any significant post-operative differences in the mean values of the markers assessed, except those of IL-6, implying that serum levels of fibrinogen, hsCRP and TNF-alpha within 24 hours after large joint replacements are not influenced by the patient's ponderal status.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6). 0 (Tumor Necrosis Factor-alpha). 9001-32-5 (Fibrinogen). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00264-018-4238-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tilinca&issn=0341-2695&title=International+Orthopaedics&atitle=Differences+in+peri-operative+serum+inflammatory+markers+between+normoponderal+and+obese+patients+undergoing+large+joint+replacement+for+osteoarthritis-a+descriptive+study.&volume=43&issue=7&spage=1735&epage=1740&date=2019&doi=10.1007%2Fs00264-018-4238-7&pmid=30488128&sid=OVID:medline
+
+<1854>
+Unique Identifier
+ 30471527
+Title
+ Polyphenols regulating microRNAs and inflammation biomarkers in obesity. [Review]
+Source
+ Nutrition. 59:150-157, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Correa TA; Rogero MM
+Authors Full Name
+ Correa, Telma Af; Rogero, Marcelo M.
+Institution
+ Correa, Telma Af. Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil.
+ Rogero, Marcelo M. Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: mmrogero@usp.br.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Gene Expression Regulation
+ Humans
+ Inflammation
+ Insulin Resistance
+ Metabolic Diseases/me [Metabolism]
+ *MicroRNAs/me [Metabolism]
+ *Obesity/ge [Genetics]
+ Oxidative Stress/ge [Genetics]
+ *Polyphenols/me [Metabolism]
+Keyword Heading
+ Adipocytes
+ Cytokines
+ Inflammation
+ Polyphenols
+ microRNAs
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is one of the most prevalent health problems worldwide. It is a complex disease that is generally accompanied by insulin resistance, increases in oxidative stress and inflammation biomarkers, and potentially, microRNA (miRNA) dysregulation. Polyphenols may act on obesity and its metabolic consequences. Circulating miRNAs have been studied as potential biomarkers for inflammatory and metabolic diseases, and their use may improve the diagnostic tools currently available and the ability to diagnose specific diseases. To our knowledge, data regarding the link between the consumption of polyphenols from food sources, miRNA expression, and inflammation biomarkers related to obesity is scarce, and most data available describing this relationship are found in cancer studies. This review focuses on the polyphenols that modulate the metabolism, inflammation, or both related to obesity to understand the extent to which miRNA expression can be modulated by dietary interventions. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs). 0 (Polyphenols).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.nut.2018.08.010
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Correa&issn=0899-9007&title=Nutrition&atitle=Polyphenols+regulating+microRNAs+and+inflammation+biomarkers+in+obesity.&volume=59&issue=&spage=150&epage=157&date=2019&doi=10.1016%2Fj.nut.2018.08.010&pmid=30471527&sid=OVID:medline
+
+<1855>
+Unique Identifier
+ 30471086
+Title
+ Subclinical atherosclerosis in psoriatic disease: relation to endocan, TNF-alpha, age of onset, and body fat.
+Source
+ International Journal of Dermatology. 58(4):456-464, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Elkamshoushi AM; Omar SS; El Abd AM; Hassan SZ; Sultan EA; Abd Elkawy E
+Author NameID
+ Omar, Salma S; ORCID: http://orcid.org/0000-0001-9546-4366
+Authors Full Name
+ Elkamshoushi, Abdelaal M; Omar, Salma S; El Abd, Amr M; Hassan, Seham Z; Sultan, Eman A; Abd Elkawy, Eman.
+Institution
+ Elkamshoushi, Abdelaal M. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
+ Omar, Salma S. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
+ El Abd, Amr M. Department of Radiodiagnosis and Interventional Radiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
+ Hassan, Seham Z. Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
+ Sultan, Eman A. Department of Community Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
+ Abd Elkawy, Eman. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Age of Onset
+ *Atherosclerosis/bl [Blood]
+ Atherosclerosis/co [Complications]
+ *Atherosclerosis/di [Diagnosis]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Carotid Intima-Media Thickness
+ Case-Control Studies
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Neoplasm Proteins/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Predictive Value of Tests
+ *Proteoglycans/bl [Blood]
+ *Psoriasis/bl [Blood]
+ Psoriasis/co [Complications]
+ ROC Curve
+ Severity of Illness Index
+ *Tumor Necrosis Factor-alpha/bl [Blood]
+ Young Adult
+Abstract
+ BACKGROUND: Psoriasis is a common multisystem inflammatory disease with several associated comorbidities. Serological markers to detect associated subclinical atherosclerosis in psoriatic patients are needed. We aimed to study serum endocan levels in psoriasis vulgaris and its relation to severity of psoriasis, systemic inflammation, associated atherosclerosis, obesity, and the possible factors affecting its level in psoriatic patients.
+
+ METHODS: This study was conducted on 30 moderate-severe psoriasis vulgaris patients and 30 healthy controls. Body mass index, body fat percent, and PASI assessments were done. Serum endocan and tumor necrosis factor-alpha levels were measured by ELISA. Carotid artery intima-media thickness measurement by high-resolution ultrasound was performed.
+
+ RESULTS: Psoriasis patients showed significantly higher serum tumor necrosis factor-alpha and endocan levels (P1 = 0.008, P2 = 0.003). Additionally, there was a statistically significant difference between mean carotid artery intima-media thickness of both groups (P = 0.005). Serum endocan levels positively correlated with PASI score (P = 0.002), tumor necrosis factor-alpha levels (P < 0.001), mean carotid artery intima-media thickness (P = 0.001), and body mass index (P < 0.001) in the patients group. Additionally, the age of onset of disease negatively correlated with serum endocan (P = 0.003).
+
+ CONCLUSION: Serum endocan is a promising marker of severity of psoriasis and associated atherosclerosis. Early onset psoriasis is associated with higher serum endocan levels. Body mass index is positively correlated with serum endocan levels. The positive correlation of endocan and tumor necrosis factor-alpha supports the regulatory effect of the cytokine on endocan production and suggests the role of endocan as an inflammatory marker. Copyright © 2018 The International Society of Dermatology.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (ESM1 protein, human). 0 (Neoplasm Proteins). 0 (Proteoglycans). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fijd.14290
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Elkamshoushi&issn=0011-9059&title=International+Journal+of+Dermatology&atitle=Subclinical+atherosclerosis+in+psoriatic+disease%3A+relation+to+endocan%2C+TNF-alpha%2C+age+of+onset%2C+and+body+fat.&volume=58&issue=4&spage=456&epage=464&date=2019&doi=10.1111%2Fijd.14290&pmid=30471086&sid=OVID:medline
+
+<1856>
+Unique Identifier
+ 30468934
+Title
+ Body composition and bone mineral density in Huntington's disease.
+Source
+ Nutrition. 59:145-149, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Costa de Miranda R; Di Lorenzo N; Andreoli A; Romano L; De Santis GL; Gualtieri P; De Lorenzo A
+Authors Full Name
+ Costa de Miranda, Renata; Di Lorenzo, Nicola; Andreoli, Angela; Romano, Lorenzo; De Santis, Gemma Lou; Gualtieri, Paola; De Lorenzo, Antonino.
+Institution
+ Costa de Miranda, Renata. PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Rome, Italy; CAPES Foundation, Ministry of Education of Brazil, Brasilia, Brazil.
+ Di Lorenzo, Nicola. Department of Surgical Sciences, University of Tor Vergata, Policlinico Tor Vergata, Rome, Italy.
+ Andreoli, Angela. Department of System Medicine, Human Physiology and Nutrition Unit, University of Rome Tor Vergata, Rome, Italy.
+ Romano, Lorenzo. Specialisation School of Food Science, University of Rome Tor Vergata, Rome, Italy.
+ De Santis, Gemma Lou. Specialisation School of Food Science, University of Rome Tor Vergata, Rome, Italy.
+ Gualtieri, Paola. PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Rome, Italy.
+ De Lorenzo, Antonino. Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and prevention, University of Rome Tor Vergata, Rome, Italy; Casa di Cura Madonna dello Scoglio, Cotronei, Italy. Electronic address: Delorenzo@uniroma2.it.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ *Body Composition
+ Body Height
+ *Body Mass Index
+ Body Weight
+ *Bone Density
+ Case-Control Studies
+ Female
+ Humans
+ Huntington Disease/co [Complications]
+ *Huntington Disease/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ Weight Loss
+ Young Adult
+Keyword Heading
+ Biomarkers
+ Body weight
+ Huntington disease
+ Lean body mass
+ Nutrition status
+ Osteoporosis
+ Truncal fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Understanding the body composition (BC) of patients with Huntington's disease (HD) could help to delay disease progression and improve treatment efficacy. The aim of this study was to assess BC parameters, including bone mineral density (BMD), and to find new biomarkers that can be early indicators for weight loss in patients with HD.
+
+ METHODS: Twenty-one age- and sex-matched patients with HD and 29 healthy controls (CT) were enrolled. For each patient, body weight (BW), height, and body mass index (BMI) were evaluated. BC and BMD were measured by dual-energy x-ray absorptiometry. Subsamples were created according to sex and percent fat mass (FM) (obese and nonobese). All analyses were carried out using SPSS version 23.
+
+ RESULTS: In all comparisons, BMD and T-score were lower in the HD group, but were not correlated with lean body mass (LBM) or FM. In the HD group, LBM and truncal fat were mostly reduced, except in women with HD whose BC appeared to be less affected by the disease than men. Furthermore, LBM (r=0.80) and truncal fat (r=0.68) were better correlated with BW than BMI (r=0.56).
+
+ CONCLUSION: Complete BC assessment can be crucial for preventive interventions and prognosis definition in patients with HD. New biomarkers such as BMD, LBM, and truncal fat can be early indicators of weight loss in patients with HD. Copyright © 2018 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.nut.2018.08.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Costa+de+Miranda&issn=0899-9007&title=Nutrition&atitle=Body+composition+and+bone+mineral+density+in+Huntington%27s+disease.&volume=59&issue=&spage=145&epage=149&date=2019&doi=10.1016%2Fj.nut.2018.08.005&pmid=30468934&sid=OVID:medline
+
+<1857>
+Unique Identifier
+ 30465249
+Title
+ Association of serum ghrelin with weight gain during pregnancy in overweight and normal women.
+Source
+ Journal of Endocrinological Investigation. 42(7):809-813, 2019 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tehranian N; Hosseini M; Ramezani-Tehrani F; Yousefi S
+Author NameID
+ Tehranian, N; ORCID: http://orcid.org/0000-0002-2137-5333
+ Hosseini, M; ORCID: http://orcid.org/0000-0002-6793-2035
+ Ramezani-Tehrani, F; ORCID: http://orcid.org/0000-0002-4609-065X
+ Yousefi, S; ORCID: http://orcid.org/0000-0001-7294-4850
+Authors Full Name
+ Tehranian, N; Hosseini, M; Ramezani-Tehrani, F; Yousefi, S.
+Institution
+ Tehranian, N. Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
+ Hosseini, M. Cellular and Molecular Research Center,Department of Anatomy, Birjand University of Medical Sciences, Birjand, Iran.
+ Ramezani-Tehrani, F. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Yousefi, S. Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, 9717853577, Iran. s.yousefi313@yahoo.com.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ *Body Mass Index
+ Case-Control Studies
+ Female
+ Follow-Up Studies
+ *Gestational Weight Gain
+ *Ghrelin/bl [Blood]
+ Humans
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ *Overweight/bl [Blood]
+ Overweight/pp [Physiopathology]
+ Pregnancy
+ Pregnancy Outcome
+ Pregnancy Trimester, First/bl [Blood]
+ Pregnancy Trimester, Second/bl [Blood]
+ Pregnancy Trimester, Third/bl [Blood]
+ Prospective Studies
+Keyword Heading
+ Ghrelin
+ Overweight
+ Pregnancy
+ Weight gain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Despite the fact that the ghrelin hormone plays pivotal role in the process of weight gain, its correlation with weighing during pregnancy has not been elucidated. Hence, the present study was conducted to evaluate the correlation between plasma ghrelin levels and gestational weight gain in overweight and normal women.
+
+ METHODS: This prospective cohort study was conducted in 27 overweight and 18 normal body mass index (BMI) pregnant women referring to Tehran health care centers. Weight gain during all trimesters of pregnancy was measured and the blood samples were collected at 8-12 (first trimester) and 16-20 weeks (second trimester) of pregnancy. The plasma total ghrelin concentration was measured by ELISA method.
+
+ RESULTS: The overweight pregnant women exhibited significantly lower weight gain at the second (p = 0.002), third trimesters (p = 0.005) as well as total weighing during pregnancy (p = 0.001) compared to the normal BMI pregnant women. There was no significant difference in plasma ghrelin levels between the groups from the first to the second trimesters of pregnancy (p > 0.05). Moreover, no correlation was found between ghrelin levels and gestational weight gain in the overweight and normal groups.
+
+ CONCLUSIONS: Our results indicate that the increased level of serum ghrelin could not be considered as a key mediator for weight gain difference during pregnancy of overweight women.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ghrelin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs40618-018-0986-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tehranian&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Association+of+serum+ghrelin+with+weight+gain+during+pregnancy+in+overweight+and+normal+women.&volume=42&issue=7&spage=809&epage=813&date=2019&doi=10.1007%2Fs40618-018-0986-x&pmid=30465249&sid=OVID:medline
+
+<1858>
+Unique Identifier
+ 30456540
+Title
+ Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia.
+Source
+ Psychopharmacology. 236(2):753-762, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang F; Wang K; Du X; Deng H; Wu HE; Yin G; Ning Y; Huang X; Teixeira AL; de Quevedo J; Soares JC; Li X; Lang X; Zhang XY
+Authors Full Name
+ Yang, Fang; Wang, Keming; Du, Xiangdong; Deng, Huiqiong; Wu, Hanjing Emily; Yin, Guangzhong; Ning, Yuping; Huang, Xingbing; Teixeira, Antonio L; de Quevedo, Joao; Soares, Jair C; Li, Xiaosi; Lang, XiaoE; Zhang, Xiang Yang.
+Institution
+ Yang, Fang. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
+ Wang, Keming. Hefei Fourth People's Hospital, Anhui Mental Health Center, Hefei, China.
+ Du, Xiangdong. Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
+ Deng, Huiqiong. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
+ Wu, Hanjing Emily. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
+ Yin, Guangzhong. Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
+ Ning, Yuping. The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
+ Huang, Xingbing. The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
+ Teixeira, Antonio L. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
+ de Quevedo, Joao. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
+ Soares, Jair C. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
+ Li, Xiaosi. Hefei Fourth People's Hospital, Anhui Mental Health Center, Hefei, China.
+ Lang, XiaoE. Department of Psychiatry, The First Clinical Medical College, Shanxi Medical University, 85 Jiefang Southern Road, Taiyuan, 030001, Shanxi, China. langxiaoe@yeah.net.
+ Zhang, Xiang Yang. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. zhangxy@psych.ac.cn.
+ Zhang, Xiang Yang. Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China. zhangxy@psych.ac.cn.
+MeSH Subject Headings
+ Adult
+ Aged
+ Antipsychotic Agents/ae [Adverse Effects]
+ Antipsychotic Agents/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ *Brain-Derived Neurotrophic Factor/bl [Blood]
+ China/ep [Epidemiology]
+ Female
+ Humans
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ci [Chemically Induced]
+ Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ci [Chemically Induced]
+ Obesity/ep [Epidemiology]
+ Psychiatric Status Rating Scales
+ Random Allocation
+ *Schizophrenia/bl [Blood]
+ Schizophrenia/dt [Drug Therapy]
+ *Schizophrenia/ep [Epidemiology]
+ *Sex Characteristics
+Keyword Heading
+ Body mass index
+ Brain-derived neurotrophic factor
+ Obesity
+ Schizophrenia
+ Sex difference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ RATIONALE AND OBJECTIVE: Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex differences in the relationship between serum BDNF levels and obesity in patients with chronic schizophrenia.
+
+ METHODS: We recruited 132 Chinese patients with chronic schizophrenia (98 males and 34 females) and compared sex differences in the body mass index (BMI), obesity, serum BDNF levels, and their associations. Psychopathology symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). A regression model with various demographic and clinical variables was applied to predict the serum levels of BDNF.
+
+ RESULTS: Female patients had a higher rate of obesity and higher BMI, but lower BDNF levels than male schizophrenia patients. A significantly negative correlation was observed between BMI and BDNF levels only in female patients but not in male patients. The multiple regression model with demographic and clinical variables significantly predicted BDNF levels only in female patients, with a medium size effect. And only in female patients, BMI made a significant contribution to this prediction.
+
+ CONCLUSION: Our results indicate significant sex differences in the obesity, BMI, BDNF levels, and their association in chronic patients with schizophrenia, showing a significant inverse correlation between BMI and BDNF levels only in female patients. Thus, sex needs to be considered when assessing the relationship between BDNF and metabolic syndromes in schizophrenia.
+Registry Number/Name of Substance
+ 0 (Antipsychotic Agents). 0 (Biomarkers). 0 (Brain-Derived Neurotrophic Factor). 7171WSG8A2 (BDNF protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00213-018-5107-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=0033-3158&title=Psychopharmacology&atitle=Sex+difference+in+the+association+of+body+mass+index+and+BDNF+levels+in+Chinese+patients+with+chronic+schizophrenia.&volume=236&issue=2&spage=753&epage=762&date=2019&doi=10.1007%2Fs00213-018-5107-1&pmid=30456540&sid=OVID:medline
+
+<1859>
+Unique Identifier
+ 30450618
+Title
+ Key pathway and gene alterations in the gastric mucosa associated with obesity and obesity-related diabetes.
+Source
+ Journal of Cellular Biochemistry. 120(4):6763-6771, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wen X; Qian C; Zhang Y; Wu R; Lu L; Zhu C; Cheng X; Cui R; You H; Mei F; Gao J; Li F; Bu L; Qu S
+Author NameID
+ Wen, Xin; ORCID: https://orcid.org/0000-0001-7017-9841
+Authors Full Name
+ Wen, Xin; Qian, Chunhua; Zhang, Yi; Wu, Ruijin; Lu, Liesheng; Zhu, Cuiling; Cheng, Xiaoyun; Cui, Rai; You, Hui; Mei, Fangyun; Gao, Jingyang; Li, Feng; Bu, Le; Qu, Shen.
+Institution
+ Wen, Xin. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Wen, Xin. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Wen, Xin. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Qian, Chunhua. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Qian, Chunhua. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Qian, Chunhua. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Zhang, Yi. Department of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, National key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
+ Wu, Ruijin. Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Lu, Liesheng. Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Zhu, Cuiling. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Zhu, Cuiling. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Zhu, Cuiling. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Cheng, Xiaoyun. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Cheng, Xiaoyun. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Cheng, Xiaoyun. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Cui, Rai. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Cui, Rai. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Cui, Rai. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ You, Hui. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ You, Hui. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ You, Hui. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Mei, Fangyun. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Mei, Fangyun. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Mei, Fangyun. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Gao, Jingyang. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Gao, Jingyang. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Gao, Jingyang. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Li, Feng. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Li, Feng. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Li, Feng. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Bu, Le. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Bu, Le. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Bu, Le. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+ Qu, Shen. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
+ Qu, Shen. National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
+ Qu, Shen. Thyroid Research Center of Shanghai, Shanghai Tenth People's Hospital, China.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Case-Control Studies
+ Computational Biology
+ Diabetes Mellitus/et [Etiology]
+ *Diabetes Mellitus/me [Metabolism]
+ Diabetes Mellitus/pa [Pathology]
+ Female
+ *Gastric Mucosa/me [Metabolism]
+ Gastric Mucosa/pa [Pathology]
+ Gene Expression Profiling
+ *Gene Expression Regulation
+ Humans
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Signal Transduction
+ *Transcriptome
+Keyword Heading
+ gastric mucosa
+ gene microarray
+ obesity
+ type 2 diabetes mellitus (T2DM)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND OBJECTIVE: The stomach plays an important role in obesity and obesity-related diabetes; yet, little is known about key pathways in the gastric mucosa associated with obesity and diabetes.
+
+ METHODS: We performed gene microarray and real time-polymerase chain reaction (RT-PCR) on gut mucosa samples from control subjects (CON), patients with simple obesity (OB), and patients with obesity and comorbid diabetes (OD) (n = 3 per group). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were used to predict the functional significance of differentially expressed genes.
+
+ RESULTS: In total, 262 genes were upregulated and 265 genes were downregulated in the OB group whereas 1756 genes were upregulated and 1053 genes were downregulated in the OD group compared with the CON group. Of these, 23 were co-regulated in both comparisons. Seven differentially expressed genes were validated by RT-PCR (NRIP3, L1CAM, TPO, P2RY1, OR8A1, ADAMTS19, and ASIC3). A functional analysis revealed that genes differentially expressed between the OB or OD and CON groups played crucial roles in metabolic, T cell, and G-protein coupled receptor biological processes, and primarily participated in the PI3K-Akt and AGE-RAGE signaling pathways.
+
+ CONCLUSIONS: Obesity and obesity-related diabetes are associated with important gene expression and pathway alterations in the stomach. Copyright © 2018 Wiley Periodicals, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fjcb.27976
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wen&issn=0730-2312&title=Journal+of+Cellular+Biochemistry&atitle=Key+pathway+and+gene+alterations+in+the+gastric+mucosa+associated+with+obesity+and+obesity-related+diabetes.&volume=120&issue=4&spage=6763&epage=6771&date=2019&doi=10.1002%2Fjcb.27976&pmid=30450618&sid=OVID:medline
+
+<1860>
+Unique Identifier
+ 30447902
+Title
+ Predictors of postpartum diabetes mellitus in patients with gestational diabetes.
+Original Title
+ Factores predictores de diabetes mellitus posparto en pacientes con diabetes gestacional.
+Source
+ Endocrinologia Diabetes Y Nutricion. 66(2):83-89, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Civantos S; Duran M; Flandez B; Merino M; Navea C; Guijarro G; Martell N; Monereo S
+Authors Full Name
+ Civantos, Soralla; Duran, Maria; Flandez, Beatriz; Merino, Maria; Navea, Cristina; Guijarro, Guadalupe; Martell, Nieves; Monereo, Susana.
+Institution
+ Civantos, Soralla. Seccion de Endocrinologia y Nutricion, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Espana; Servicio de Endocrinologia y Nutricion, Hospital Universitario Quiron, Madrid, Espana. Electronic address: zulemaciv@hotmail.com.
+ Duran, Maria. Servicio de Endocrinologia y Nutricion, Hospital Universitario de Getafe, Getafe, Madrid, Espana.
+ Flandez, Beatriz. Servicio de Endocrinologia y Nutricion, Hospital Universitario de Getafe, Getafe, Madrid, Espana.
+ Merino, Maria. Servicio de Endocrinologia y Nutricion, Hospital Universitario de Getafe, Getafe, Madrid, Espana.
+ Navea, Cristina. Servicio de Endocrinologia y Nutricion, Hospital Universitario de Getafe, Getafe, Madrid, Espana.
+ Guijarro, Guadalupe. Servicio de Endocrinologia y Nutricion, Hospital Universitario de Getafe, Getafe, Madrid, Espana.
+ Martell, Nieves. Unidad de Hipertension, Hospital Universitario Clinico San Carlos, Madrid, Espana.
+ Monereo, Susana. Servicio de Endocrinologia y Nutricion, Hospital Universitario Gregorio Maranon, Madrid, Espana.
+MeSH Subject Headings
+ Adult
+ Anthropometry
+ Biomarkers
+ Blood Glucose/an [Analysis]
+ Combined Modality Therapy
+ *Diabetes Mellitus/ep [Epidemiology]
+ Diabetes, Gestational/bl [Blood]
+ Diabetes, Gestational/dh [Diet Therapy]
+ Diabetes, Gestational/dt [Drug Therapy]
+ *Diabetes, Gestational
+ Diet, Diabetic
+ Female
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Insulin/tu [Therapeutic Use]
+ Obesity/ep [Epidemiology]
+ Postpartum Period
+ Pregnancy
+ Pregnancy Complications/ep [Epidemiology]
+ Prevalence
+ Retrospective Studies
+ Risk Factors
+ Sensitivity and Specificity
+Keyword Heading
+ Diabetes gestacional
+ Diabetes mellitus
+ Factor de riesgo
+ Gestational diabetes
+ Oral glucose tolerance test
+ Posparto
+ Postpartum
+ Risk factor
+ Sobrecarga oral de glucosa
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Gestational diabetes (GD) is related to development of diabetes mellitus (DM) after delivery. The predictive factors in this association are not yet well defined. Objetive: to study the predictive factors of dysglucosis in the postpartum period in a sample of patients with GD.
+
+ MATERIAL AND METHODS: A total of 1765 women with DG were studied. Variables analyzed: anthropometric data and maternal history. Glycemia in OGTT with 100g (basal: 1, 2 and 3h) and HbA1c. Use of insulin in pregnancy. The OGTT with 75g and HbA1c at 3 months after delivery.
+
+ RESULTS: Postpartum DM prevalence 2.1%. Among these patients, there was a higher percentage of patients with a history of GD (25.9 vs. 12.9%; P<.05), pre-pregnancy obesity (20.8 vs. 14.9%; P<.05) and insulin use during pregnancy (79.2 vs. 20%; P<.01). In the OGTT with 100g, the number of pathological points was higher (3.18+/-0.69 in DM vs. 2.3+/-0.28 normal, 2.6+/-0.47 IFG, 2.5+/-0.32 IGT; P<.001). In the OGTT 100g, the blood glucose level above which the diagnosis of postpartum DM is most likely is 189mg/dl in the 2h determination (S: 86.2%, E: 72%). A level of HbA1c>5.9% during pregnancy has a specificity of 95.9% for the diagnosis of postpartum DM in our sample.
+
+ CONCLUSION: We show factors associated with the diagnosis of postpartum DM, among which are quantitative determinations such as glycemia at 2h of the OGTT with 100g and HbA1c during pregnancy in patients with DG. Copyright © 2018. Publicado por Elsevier Espana, S.L.U.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (Insulin).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.endinu.2018.08.013
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Civantos&issn=2530-0180&title=Endocrinologia+Diabetes+Y+Nutricion&atitle=Factores+predictores+de+diabetes+mellitus+posparto+en+pacientes+con+diabetes+gestacional.&volume=66&issue=2&spage=83&epage=89&date=2019&doi=10.1016%2Fj.endinu.2018.08.013&pmid=30447902&sid=OVID:medline
+
+<1861>
+Unique Identifier
+ 30447223
+Title
+ Obesity and dyslipidemia. [Review]
+Source
+ Metabolism: Clinical & Experimental. 92:71-81, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vekic J; Zeljkovic A; Stefanovic A; Jelic-Ivanovic Z; Spasojevic-Kalimanovska V
+Authors Full Name
+ Vekic, Jelena; Zeljkovic, Aleksandra; Stefanovic, Aleksandra; Jelic-Ivanovic, Zorana; Spasojevic-Kalimanovska, Vesna.
+Institution
+ Vekic, Jelena. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. Electronic address: jelena.vekic@pharmacy.bg.ac.rs.
+ Zeljkovic, Aleksandra. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
+ Stefanovic, Aleksandra. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
+ Jelic-Ivanovic, Zorana. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
+ Spasojevic-Kalimanovska, Vesna. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
+MeSH Subject Headings
+ Biomarkers
+ Cardiovascular Diseases/pc [Prevention & Control]
+ *Dyslipidemias/co [Complications]
+ *Dyslipidemias/th [Therapy]
+ Humans
+ *Obesity/co [Complications]
+ *Obesity/th [Therapy]
+Keyword Heading
+ Adipokines
+ Insulin resistance
+ MicroRNA
+ PCSK9
+ Small, dense LDL
+ Sphingosine-1-phosphate
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines. However, recent evidence suggests that obesity-induced dyslipidemia is not a unique pathophysiological entity, but rather has distinct characteristics depending on many individual factors. In line with that, in a subgroup of metabolically healthy obese (MHO) individuals, dyslipidemia is less prominent or even absent. In this review, we will address the main characteristics of dyslipidemia and mechanisms that induce its development in obesity. The fields, which should be further investigated to expand our knowledge on obesity-related dyslipidemia and potentially yield new strategies for prevention and management of cardiometabolic risk, will be highlighted. Also, we will discuss recent findings on novel lipid biomarkers in obesity, in particular proprotein convertase subtilisin/kexin type 9 (PCSK9), as the key molecule that regulates metabolism of low-density lipoproteins (LDL), and sphingosine-1-phosphate (S1P), as one of the most important mediators of high-density lipoprotein (HDL) particles function. Special attention will be given to microRNAs and their potential use as biomarkers of obesity-associated dyslipidemia. Copyright © 2018 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.metabol.2018.11.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vekic&issn=0026-0495&title=Metabolism%3A+Clinical+%26+Experimental&atitle=Obesity+and+dyslipidemia.&volume=92&issue=&spage=71&epage=81&date=2019&doi=10.1016%2Fj.metabol.2018.11.005&pmid=30447223&sid=OVID:medline
+
+<1862>
+Unique Identifier
+ 30447149
+Title
+ Metabolic and bone profile in postmenopausal women with and without type 2 diabetes: a cross-sectional study.
+Source
+ Romanian Journal of Internal Medicine. 57(1):61-67, 2019 Mar 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dumitru N; Carsote M; Cocolos A; Petrova E; Olaru M; Caragheorgheopol A; Dumitrache C; Ghemigian A
+Authors Full Name
+ Dumitru, Nicoleta; Carsote, Mara; Cocolos, Andra; Petrova, Eugenia; Olaru, Maria; Caragheorgheopol, Andra; Dumitrache, Constantin; Ghemigian, Adina.
+Institution
+ Dumitru, Nicoleta. "C.I. Parhon" National Institute of Endocrinology, Bucharest,Romania.
+ Dumitru, Nicoleta. "Carol Davila" University of Medicine and Pharmacy, Bucharest,Romania.
+ Carsote, Mara. "C.I. Parhon" National Institute of Endocrinology, Bucharest,Romania.
+ Carsote, Mara. "Carol Davila" University of Medicine and Pharmacy, Bucharest,Romania.
+ Cocolos, Andra. "C.I. Parhon" National Institute of Endocrinology, Bucharest,Romania.
+ Cocolos, Andra. "Carol Davila" University of Medicine and Pharmacy, Bucharest,Romania.
+ Petrova, Eugenia. "C.I. Parhon" National Institute of Endocrinology, Bucharest,Romania.
+ Petrova, Eugenia. "Carol Davila" University of Medicine and Pharmacy, Bucharest,Romania.
+ Olaru, Maria. "C.I. Parhon" National Institute of Endocrinology, Bucharest,Romania.
+ Caragheorgheopol, Andra. "C.I. Parhon" National Institute of Endocrinology, Bucharest,Romania.
+ Dumitrache, Constantin. "Carol Davila" University of Medicine and Pharmacy, Bucharest,Romania.
+ Ghemigian, Adina. "C.I. Parhon" National Institute of Endocrinology, Bucharest,Romania.
+ Ghemigian, Adina. "Carol Davila" University of Medicine and Pharmacy, Bucharest,Romania.
+MeSH Subject Headings
+ 25-Hydroxyvitamin D 2/me [Metabolism]
+ Aged
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ *Bone Density
+ Bone Resorption
+ *Bone and Bones/me [Metabolism]
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Glycated Hemoglobin/me [Metabolism]
+ Humans
+ Middle Aged
+ Obesity/me [Metabolism]
+ Osteocalcin/me [Metabolism]
+ Peptide Fragments/me [Metabolism]
+ *Postmenopause/me [Metabolism]
+ Procollagen/me [Metabolism]
+Keyword Heading
+ bone density
+ diabetic bone disease
+ osteocalcin
+ trabecular bone score
+ type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Current studies support the implication of metabolic changes associated with type 2 diabetes in altering bone metabolism, structure and resistance.
+
+ OBJECTIVE: We conducted a cross-sectional study on postmenopausal women aimed to analyze the differences in metabolic and bone profile in patients with and without type 2 diabetes Methods. We analyzed the metabolic and bone profile in postmenopausal women with and without type 2 diabetes (T2DM). Clinical, metabolic, hormonal parameters, along with lumbar, hip and femoral bone mineral density (BMD) and trabecular bone score (TBS) were evaluated.
+
+ RESULTS: 56 women with T2DM(63.57+/-8.97 years) and 83 non-T2DM (60.21+/-8.77 years) were included. T2DM patients presented a higher value of body mass index (BMI) and BMD vs. control group (p = 0.001; p = 0.03-lumbar level, p = 0.07-femoral neck and p = 0.001-total hip). Also, BMI correlated positively with lumbar-BMD and glycated hemoglobin (HbA1c) (r = 0.348, p = 0.01; r = 0.269, p = 0.04), correlation maintained even after age and estimated glomerular filtration rate (eGFR) adjustment (r = 0.383, p = 0.005; r = 0.237, p = 0.08). Diabetic patients recorded lower levels of 25(OH)D(p = 0.05), bone markers (p <= 0.05) and TBS(p = 0.07). For the entire patient group we found a negative correlation between HbA1c level and bone markers: r = -0.358, p = 0.0005-osteocalcin, r = -0.40, p = 0.0005-P1NP, r = -0.258, p = 0.005-crosslaps.
+
+ CONCLUSIONS: Our results indicate the presence of altered bone microarchitecture in T2DZ patients according to the TBS score, combined with lower levels of bone markers, with a statistically significant negative correlation between HbA1c level and bone markers.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycated Hemoglobin A). 0 (Peptide Fragments). 0 (Procollagen). 0 (hemoglobin A1c protein, human). 0 (procollagen Type I N-terminal peptide). 104982-03-8 (Osteocalcin). 21343-40-8 (25-Hydroxyvitamin D 2).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2478%2frjim-2018-0036
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dumitru&issn=1220-4749&title=Romanian+Journal+of+Internal+Medicine&atitle=Metabolic+and+bone+profile+in+postmenopausal+women+with+and+without+type+2+diabetes%3A+a+cross-sectional+study.&volume=57&issue=1&spage=61&epage=67&date=2019&doi=10.2478%2Frjim-2018-0036&pmid=30447149&sid=OVID:medline
+
+<1863>
+Unique Identifier
+ 30419221
+Title
+ Exosomes in inflammation and role as biomarkers. [Review]
+Source
+ Clinica Chimica Acta. 488:165-171, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Console L; Scalise M; Indiveri C
+Authors Full Name
+ Console, Lara; Scalise, Mariafrancesca; Indiveri, Cesare.
+Institution
+ Console, Lara. Department DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P. Bucci cubo 4C, 87036 Arcavacata di Rende, CS, Italy.
+ Scalise, Mariafrancesca. Department DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P. Bucci cubo 4C, 87036 Arcavacata di Rende, CS, Italy.
+ Indiveri, Cesare. Department DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P. Bucci cubo 4C, 87036 Arcavacata di Rende, CS, Italy. Electronic address: cesare.indiveri@unical.it.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ *Biomarkers/me [Metabolism]
+ Diabetes Mellitus/me [Metabolism]
+ *Exosomes/me [Metabolism]
+ Humans
+ *Inflammation/me [Metabolism]
+ Kidney Diseases/me [Metabolism]
+ *Neoplasms/me [Metabolism]
+ Obesity/me [Metabolism]
+Keyword Heading
+ Biomarkers
+ Cancer metabolism
+ Exosomes
+ Inflammation
+ SLC
+ Transporters
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Exosomes are endosomal-derived nano-vesicles. They are considered vehicles through which donor cells transfer proteins, lipids and nucleic acids to target cells thus influencing their metabolism. Exosomes are involved in inflammatory processes that play a pivotal role in a large number of pathologic states including cancer, inflammatory bowel diseases, type 2 diabetes, obesity, rheumatoid arthritis and neurodegenerative diseases. The association between inflammation and change in nature or expression level of some exosomal cargos is the fundamental step for identifying possible novel biomarkers of inflammatory-based diseases. A novel interesting exosome cargo is the SLC22A5 transport protein whose level in exosomes is regulated by the pro-inflammatory cytokine INF-gamma. The advantage of using exosomes as a biomarker vehicle consists of their ease of collection from body fluids such as urine and saliva as they may represent a non-invasive means for screening human pathology. Copyright © 2018 Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.cca.2018.11.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Console&issn=0009-8981&title=Clinica+Chimica+Acta&atitle=Exosomes+in+inflammation+and+role+as+biomarkers.&volume=488&issue=&spage=165&epage=171&date=2019&doi=10.1016%2Fj.cca.2018.11.009&pmid=30419221&sid=OVID:medline
+
+<1864>
+Unique Identifier
+ 30419135
+Title
+ A Wide Complex Tachycardia in a Woman During Exercise: Did She Tread Into Dangerous Territory?.
+Source
+ JAMA Internal Medicine. 179(1):101-103, 2019 Jan 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Muniyappa A; Padmanabhan A; Goldschlager N
+Authors Full Name
+ Muniyappa, Anoop; Padmanabhan, Arun; Goldschlager, Nora.
+Institution
+ Muniyappa, Anoop. Department of Medicine, University of California, San Francisco.
+ Padmanabhan, Arun. Department of Medicine, University of California, San Francisco.
+ Goldschlager, Nora. Department of Medicine, University of California, San Francisco.
+ Goldschlager, Nora. Division of Cardiology, Department of Medicine, Zuckerberg San Francisco General Hospital, San Francisco, California.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Bundle-Branch Block/di [Diagnosis]
+ *Bundle-Branch Block/et [Etiology]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Dyslipidemias/co [Complications]
+ Electrocardiography
+ *Exercise
+ Exercise Test
+ Female
+ Humans
+ Hypertension/co [Complications]
+ Obesity/co [Complications]
+ Tachycardia
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Case Reports. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1001%2fjamainternmed.2018.6207
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Muniyappa&issn=2168-6106&title=JAMA+Internal+Medicine&atitle=A+Wide+Complex+Tachycardia+in+a+Woman+During+Exercise%3A+Did+She+Tread+Into+Dangerous+Territory%3F.&volume=179&issue=1&spage=101&epage=103&date=2019&doi=10.1001%2Fjamainternmed.2018.6207&pmid=30419135&sid=OVID:medline
+
+<1865>
+Unique Identifier
+ 30418574
+Title
+ Central Nervous System and Peripheral Hormone Responses to a Meal in Children.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 104(5):1471-1483, 2019 05 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Roth CL; Melhorn SJ; Elfers CT; Scholz K; De Leon MRB; Rowland M; Kearns S; Aylward E; Grabowski TJ; Saelens BE; Schur EA
+Authors Full Name
+ Roth, Christian L; Melhorn, Susan J; Elfers, Clinton T; Scholz, Kelley; De Leon, Mary Rosalynn B; Rowland, Maya; Kearns, Sue; Aylward, Elizabeth; Grabowski, Thomas J; Saelens, Brian E; Schur, Ellen A.
+Institution
+ Roth, Christian L. Seattle Children's Research Institute, Seattle, Washington.
+ Roth, Christian L. Department of Pediatrics, University of Washington, Seattle, Washington.
+ Melhorn, Susan J. Department of Medicine, General Internal Medicine, University of Washington, Seattle, Washington.
+ Elfers, Clinton T. Seattle Children's Research Institute, Seattle, Washington.
+ Scholz, Kelley. Seattle Children's Research Institute, Seattle, Washington.
+ De Leon, Mary Rosalynn B. Department of Medicine, General Internal Medicine, University of Washington, Seattle, Washington.
+ Rowland, Maya. Seattle Children's Research Institute, Seattle, Washington.
+ Kearns, Sue. Seattle Children's Research Institute, Seattle, Washington.
+ Aylward, Elizabeth. Seattle Children's Research Institute, Seattle, Washington.
+ Grabowski, Thomas J. Department of Radiology, Magnetic Resonance Research Laboratory, University of Washington, Seattle, Washington.
+ Saelens, Brian E. Seattle Children's Research Institute, Seattle, Washington.
+ Schur, Ellen A. Department of Medicine, General Internal Medicine, University of Washington, Seattle, Washington.
+MeSH Subject Headings
+ *Appetite
+ *Biomarkers/me [Metabolism]
+ *Brain/pp [Physiopathology]
+ Case-Control Studies
+ Child
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Ghrelin/me [Metabolism]
+ Glucagon-Like Peptide 1/me [Metabolism]
+ Humans
+ Insulin/me [Metabolism]
+ Magnetic Resonance Imaging/mt [Methods]
+ Male
+ *Meals
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Peptide YY/me [Metabolism]
+ Postprandial Period
+ Prognosis
+ *Satiation
+Abstract
+ CONTEXT: Behavioral studies suggest that responses to food consumption are altered in children with obesity (OB).
+
+ OBJECTIVE: To test central nervous system and peripheral hormone response by functional MRI and satiety-regulating hormone levels before and after a meal.
+
+ DESIGN AND SETTING: Cross-sectional study comparing children with OB and children of healthy weight (HW) recruited from across the Puget Sound region of Washington.
+
+ PARTICIPANTS: Children (9 to 11 years old; OB, n = 54; HW, n = 22), matched for age and sex.
+
+ INTERVENTION AND OUTCOME MEASURES: Neural activation to images of high- and low-calorie food and objects was evaluated across a set of a priori appetite-processing regions that included the ventral and dorsal striatum, amygdala, substantia nigra/ventral tegmental area, insula, and medial orbitofrontal cortex. Premeal and postmeal hormones (insulin, peptide YY, glucagon-like peptide-1, active ghrelin) were measured.
+
+ RESULTS: In response to a meal, average brain activation by high-calorie food cues vs objects in a priori regions was reduced after meals in children of HW (Z = -3.5, P < 0.0001), but not in children with OB (z = 0.28, P = 0.78) despite appropriate meal responses by gut hormones. Although premeal average brain activation by high-calorie food cues was lower in children with OB vs children of HW, postmeal activation was higher in children with OB (Z = -2.1, P = 0.04 and Z = 2.3, P = 0.02, respectively). An attenuated central response to a meal was associated with greater degree of insulin resistance.
+
+ CONCLUSIONS: Our data suggest that children with OB exhibit an attenuated central, as opposed to gut hormone, response to a meal, which may predispose them to overconsumption of food or difficulty with weight loss. Copyright © 2019 Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ghrelin). 0 (Insulin). 106388-42-5 (Peptide YY). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1210%2fjc.2018-01525
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Roth&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Central+Nervous+System+and+Peripheral+Hormone+Responses+to+a+Meal+in+Children.&volume=104&issue=5&spage=1471&epage=1483&date=2019&doi=10.1210%2Fjc.2018-01525&pmid=30418574&sid=OVID:medline
+
+<1866>
+Unique Identifier
+ 30415161
+Title
+ Abdominal obesity in normal weight versus overweight and obese hemodialysis patients: Associations with nutrition, inflammation, muscle strength, and quality of life.
+Source
+ Nutrition. 59:7-13, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Beberashvili I; Azar A; Abu Hamad R; Sinuani I; Feldman L; Maliar A; Stav K; Efrati S
+Authors Full Name
+ Beberashvili, Ilia; Azar, Ada; Abu Hamad, Ramzia; Sinuani, Inna; Feldman, Leonid; Maliar, Amit; Stav, Kobi; Efrati, Shai.
+Institution
+ Beberashvili, Ilia. Nephrology Division, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine Tel Aviv University, Israel. Electronic address: iliab@asaf.health.gov.il.
+ Azar, Ada. Nutrition Department, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine Tel Aviv University, Israel.
+ Abu Hamad, Ramzia. Nephrology Division, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine Tel Aviv University, Israel.
+ Sinuani, Inna. Pathology Department, Assuta Ashdod University Hospital, Ashdod, Israel.
+ Feldman, Leonid. Nephrology Division, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine Tel Aviv University, Israel.
+ Maliar, Amit. The Kamila Gonczarowski Institute of Gastroenterology, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine Tel Aviv University, Israel.
+ Stav, Kobi. Urology Department, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
+ Efrati, Shai. Nephrology Division, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine Tel Aviv University, Israel.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Aged
+ Biomarkers/bl [Blood]
+ Body Composition
+ Body Mass Index
+ Cholesterol/bl [Blood]
+ Cross-Sectional Studies
+ Dietary Proteins/an [Analysis]
+ Female
+ Hand Strength
+ Humans
+ *Ideal Body Weight/ph [Physiology]
+ Inflammation
+ Inflammation Mediators/bl [Blood]
+ Leptin/bl [Blood]
+ Male
+ Middle Aged
+ Muscle Strength/ph [Physiology]
+ Nutritional Status
+ *Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ *Obesity, Abdominal/pp [Physiopathology]
+ Obesity, Abdominal/th [Therapy]
+ *Overweight/pp [Physiopathology]
+ Overweight/th [Therapy]
+ Quality of Life
+ *Renal Dialysis/sn [Statistics & Numerical Data]
+ Treatment Outcome
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ Abdominal obesity
+ Adipokines
+ Hemodialysis
+ Inflammation
+ Malnutrition
+ Obesity
+ Quality of life
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The biological basis of abdominal obesity leading to more severe outcomes in patients with normal body mass index (BMI) on maintenance hemodialysis (MHD) is unclear. The aim of this study was to compare the properties of abdominal obesity in different BMI categories of patients on MHD.
+
+ METHODS: We performed a cross-sectional study of 188 MHD patients (52.7% women; mean age, 69.4 +/- 11.5 y) with abdominal obesity in different BMI groups using criteria from the World Health Organization. Appetite and dietary intake, body composition, handgrip strength, malnutrition inflammation score (MIS), inflammatory biomarkers, adipokines, and health-related quality-of-life (QoL) questionnaires were studied.
+
+ RESULTS: According to multivariable analyses, abdominally obese patients with normal BMIs consumed less protein per day (P=0.04); had lower measurements of surrogates of lean (P < 0.001) and fat mass (P < 0.001); and had higher total cholesterol, tumor necrosis factor-alpha (P < 0.05), and ratios of adiponectin to leptin (P=0.003) than overweight and obese patients with abdominal obesity. Multivariable analyses showed no differences in handgrip strength among the study groups. The abdominally obese study participants with normal weight had significantly lower scores in role physical (P=0.003) and pain (P=0.04) scales after multivariable adjustments.
+
+ CONCLUSIONS: Normal-weight MHD patients with abdominal obesity exhibited a more proatherogenic profile in terms of inflammatory markers and adipokine expression, lower body composition reserves, and lower physical ability than patients with abdominal obesity with overweight and obesity. This at least partially explains the abdominal obesity paradox in the MHD population in which worse clinical outcomes are seen in abdominally obese patients with normal BMIs, as opposed to overweight and obese patients who are also abdominally obese. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Dietary Proteins). 0 (Inflammation Mediators). 0 (Leptin). 0 (Tumor Necrosis Factor-alpha). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.nut.2018.08.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Beberashvili&issn=0899-9007&title=Nutrition&atitle=Abdominal+obesity+in+normal+weight+versus+overweight+and+obese+hemodialysis+patients%3A+Associations+with+nutrition%2C+inflammation%2C+muscle+strength%2C+and+quality+of+life.&volume=59&issue=&spage=7&epage=13&date=2019&doi=10.1016%2Fj.nut.2018.08.002&pmid=30415161&sid=OVID:medline
+
+<1867>
+Unique Identifier
+ 30411703
+Title
+ Screening for hepatic fibrosis and steatosis in Turkish patients with type 2 diabetes mellitus: A transient elastography study.
+Source
+ Turkish Journal of Gastroenterology. 30(3):266-270, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Demir M; Deyneli O; Yilmaz Y
+Authors Full Name
+ Demir, Meryem; Deyneli, Oguzhan; Yilmaz, Yusuf.
+Institution
+ Demir, Meryem. Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey.
+ Deyneli, Oguzhan. Department of Endocrinology and Metabolism, Marmara University School of Medicine, Istanbul, Turkey;Department of Endocrinology and Metabolism, Koc University School of Medicine, Istanbul, Turkey.
+ Yilmaz, Yusuf. Department of Gastroenterology, Marmara University School of Medicine, Istanbul, Turkey;Institute of Gastroenterology, Marmara University, Istanbul, Turkey.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Cohort Studies
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/dg [Diagnostic Imaging]
+ *Elasticity Imaging Techniques/mt [Methods]
+ Female
+ Humans
+ Liver/dg [Diagnostic Imaging]
+ Liver/pa [Pathology]
+ *Liver Cirrhosis/dg [Diagnostic Imaging]
+ Liver Cirrhosis/ep [Epidemiology]
+ Liver Cirrhosis/et [Etiology]
+ Male
+ *Mass Screening/mt [Methods]
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/dg [Diagnostic Imaging]
+ Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/dg [Diagnostic Imaging]
+ Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Obesity/co [Complications]
+ Obesity/dg [Diagnostic Imaging]
+ Obesity/ep [Epidemiology]
+ Prevalence
+ Turkey/ep [Epidemiology]
+Abstract
+ BACKGROUND/AIMS: Non-alcoholic fatty liver disease is highly prevalent in patients with type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate the potential usefulness of transient elastography (TE), which is a technique that allows measuring both fibrosis and liver fat content simultaneously, as a screening tool for hepatic involvement in Turkish patients with T2DM.
+
+ MATERIALS AND METHODS: We obtained liver stiffness measurements (LSMs, as a measure of fibrosis) and controlled attenuation parameter (CAP, as a marker of steatosis) in 124 (46 males and 78 females; mean body mass index (BMI): 33.2+/-6.6 kg/m2) Turkish patients with T2DM. The prevalence rates of overweight, obesity, and metabolic syndrome in our sample were 28.2%, 64.5%, and 77.4%, respectively. Probe-specific LSM cut-off values were used to define advanced fibrosis (>F3) and cirrhosis (F4) (M probe: F3=9.6-11.4 kPa, F4 >11.5 kPa and XL probe: F3=9.3-10.9 kPa, F4 >11.0 kPa). Mild, moderate, and severe steatosis were defined as CAP 222-232 dB/m, CAP 233-289 dB/m, and CAP >290 dB/m, respectively.
+
+ RESULTS: Advanced fibrosis and cirrhosis were identified in 21 (16.9%) and 10 (8.0%) patients, respectively. TE-defined hepatic steatosis (CAP>222 dB/m) was detected in 117 (94.3%) patients. Mild, moderate, and severe steatosis were identified in 0, 29, and 88 patients, respectively.
+
+ CONCLUSION: TE is a useful non-invasive imaging modality to screen for liver involvement in Turkish patients with T2DM. High rates of TE-defined fibrosis and steatosis in our sample reflect the presence of an elevated mean BMI.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Evaluation Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.5152%2ftjg.2018.18559
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Demir&issn=1300-4948&title=Turkish+Journal+of+Gastroenterology&atitle=Screening+for+hepatic+fibrosis+and+steatosis+in+Turkish+patients+with+type+2+diabetes+mellitus%3A+A+transient+elastography+study.&volume=30&issue=3&spage=266&epage=270&date=2019&doi=10.5152%2Ftjg.2018.18559&pmid=30411703&sid=OVID:medline
+
+<1868>
+Unique Identifier
+ 30409739
+Title
+ Reduced levels of vasopressin, an independent mechanism in the obesity paradox in patients with chronic heart failure: Insights from the DAMOCLES study.
+Source
+ International Journal of Cardiology. 276:171-176, 2019 Feb 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gavalda-Manso M; Jimenez-Marrero S; Cainzos-Achirica M; Garay A; Enjuanes C; Yun S; Diez C; Gonzalez-Costello J; Tajes M; Farre N; Duran X; Comin-Colet J
+Authors Full Name
+ Gavalda-Manso, Meritxell; Jimenez-Marrero, Santiago; Cainzos-Achirica, Miguel; Garay, Alberto; Enjuanes, Cristina; Yun, Sergi; Diez, Carles; Gonzalez-Costello, Jose; Tajes, Marta; Farre, Nuria; Duran, Xavier; Comin-Colet, Josep.
+Institution
+ Gavalda-Manso, Meritxell. School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.
+ Jimenez-Marrero, Santiago. Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
+ Cainzos-Achirica, Miguel. Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Department of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; School of Medicine and Medical Sciences, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain; RTI Health Solutions, Pharmacoepidemiology and Risk Management, Barcelona, Spain.
+ Garay, Alberto. Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
+ Enjuanes, Cristina. Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
+ Yun, Sergi. Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Internal Medicine, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Diez, Carles. Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Advanced Heart Failure Unit, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Gonzalez-Costello, Jose. Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Advanced Heart Failure Unit, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
+ Tajes, Marta. Heart Diseases Biomedical Research Group (GREC), Hospital del Mar Biomedical Research Institute (IMIM), Barcelona, Spain.
+ Farre, Nuria. Heart Diseases Biomedical Research Group (GREC), Hospital del Mar Biomedical Research Institute (IMIM), Barcelona, Spain; Heart Failure Unit, Department of Cardiology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain; Department of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.
+ Duran, Xavier. Methodology and Statistical Support Unit, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
+ Comin-Colet, Josep. Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, Universitat de Barcelona, Barcelona, Spain. Electronic address: jcomin@bellvitgehospital.cat.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Chronic Disease
+ Cohort Studies
+ Female
+ *Heart Failure/bl [Blood]
+ *Heart Failure/di [Diagnosis]
+ Heart Failure/pp [Physiopathology]
+ Humans
+ Male
+ Middle Aged
+ *Neurophysins/bl [Blood]
+ *Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ Prospective Studies
+ *Protein Precursors/bl [Blood]
+ *Vasopressins/bl [Blood]
+Keyword Heading
+ Heart failure
+ Neurohormonal hypothesis
+ Obesity
+ Sympathetic
+ Vasopressin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: An "obesity paradox" has been described in patients with chronic heart failure (CHF), obese patients having a better survival. Vasopressin is elevated in patients with CHF, and higher levels are associated with worsening severity of the disease. We aimed at evaluating the relationship between body mass index (BMI), obesity (BMI >=30kg/m2), and vasopressin in patients with CHF, as well as the prognostic implications of vasopressin across the full spectrum of BMI values.
+
+ METHODS: We included 1132 consecutive CHF patients referred to a multidisciplinary CHF unit. BMI and vasopressin levels were measured at baseline, and their association was evaluated using multivariable linear and logistic regression models. Death was evaluated after a median follow-up of 2.93years and using Cox regression analyses.
+
+ RESULTS: Mean age was 73years, 43% women, mean BMI 28kg/m2. Vasopressin levels were independently associated with all-cause death across the whole spectrum of BMI values, and were significantly lower in obese as compared to non-obese patients (median adjusted estimated levels of log-vasopressin in obese patients 2.57 [95% CI 1.5-3.67], in non-obese patients 3.16 [95% CI 2.11-4.23]; p<0.001). Also, the higher the BMI, the lower the vasopressin levels, at least for patients with BMI <35kg/m2. Subgroup analyses stratifying by left ventricle ejection fraction and sensitivity analyses further adjusting for norepinephrin levels yielded similar findings.
+
+ CONCLUSIONS: Reduced levels of vasopressin may represent an independent mechanism in the survival paradox in obese patients with CHF. Studies including larger samples of patients BMI >=35kg/m2 are needed. Copyright © 2018. Published by Elsevier B.V.
+Registry Number/Name of Substance
+ 0 (AVP protein, human). 0 (Biomarkers). 0 (Neurophysins). 0 (Protein Precursors). 11000-17-2 (Vasopressins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ijcard.2018.10.094
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gavalda-Manso&issn=0167-5273&title=International+Journal+of+Cardiology&atitle=Reduced+levels+of+vasopressin%2C+an+independent+mechanism+in+the+obesity+paradox+in+patients+with+chronic+heart+failure%3A+Insights+from+the+DAMOCLES+study.&volume=276&issue=&spage=171&epage=176&date=2019&doi=10.1016%2Fj.ijcard.2018.10.094&pmid=30409739&sid=OVID:medline
+
+<1869>
+Unique Identifier
+ 30409485
+Title
+ Overnight Change in Urinary Prostacyclin and Thromboxane in Obstructive Sleep Apnea.
+Source
+ Archivos De Bronconeumologia. 55(6):334-336, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Suarez-Giron MC; Almendros I; Roca-Ferrer J; Picado C
+Authors Full Name
+ Suarez-Giron, Monique C; Almendros, Isaac; Roca-Ferrer, Jordi; Picado, Cesar.
+Institution
+ Suarez-Giron, Monique C. Laboratori del Son, Servei de Pneumologia, Hospital Clinic, Barcelona, Spain.
+ Almendros, Isaac. Unitat de Biofisica i Bioenginyeria, Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
+ Roca-Ferrer, Jordi. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
+ Picado, Cesar. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain; Department of Pneumology and Respiratory Allergy, Hospital Clinic, Barcelona, Spain. Electronic address: cpicado@clinic.cat.
+MeSH Subject Headings
+ Aged
+ Biomarkers/ur [Urine]
+ Female
+ Humans
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/ur [Urine]
+ Pilot Projects
+ Polysomnography
+ *Prostaglandins I/ur [Urine]
+ Severity of Illness Index
+ Sleep/ph [Physiology]
+ Sleep Apnea, Obstructive/co [Complications]
+ *Sleep Apnea, Obstructive/ur [Urine]
+ *Thromboxanes/ur [Urine]
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Prostaglandins I). 0 (Thromboxanes).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.arbres.2018.09.017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Suarez-Giron&issn=2173-5751&title=Archivos+De+Bronconeumologia&atitle=Overnight+Change+in+Urinary+Prostacyclin+and+Thromboxane+in+Obstructive+Sleep+Apnea.&volume=55&issue=6&spage=334&epage=336&date=2019&doi=10.1016%2Fj.arbres.2018.09.017&pmid=30409485&sid=OVID:medline
+
+<1870>
+Unique Identifier
+ 30407222
+Title
+ Emerging role for kynurenines in metabolic pathologies. [Review]
+Source
+ Current Opinion in Clinical Nutrition & Metabolic Care. 22(1):82-90, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Liu JJ; Movassat J; Portha B
+Authors Full Name
+ Liu, Jun-Jun; Movassat, Jamileh; Portha, Bernard.
+Institution
+ Liu, Jun-Jun. Laboratoire B2PE (Biologie et Pathologie du Pancreas Endocrine), Unite BFA (Biologie Fonctionnelle et Adaptive), Universite Paris-Diderot, Sorbonne-Paris-Cite, Paris, France.
+MeSH Subject Headings
+ Aging/me [Metabolism]
+ Aging/pa [Pathology]
+ Animals
+ Atherosclerosis/me [Metabolism]
+ Atherosclerosis/pa [Pathology]
+ Biomarkers/me [Metabolism]
+ Diabetes Mellitus/me [Metabolism]
+ Diabetes Mellitus/pa [Pathology]
+ Homeostasis
+ Humans
+ Islets of Langerhans/me [Metabolism]
+ Islets of Langerhans/pa [Pathology]
+ *Kynurenine/me [Metabolism]
+ Metabolic Diseases/me [Metabolism]
+ *Metabolic Diseases/pa [Pathology]
+ *Metabolic Networks and Pathways
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ *Tryptophan/me [Metabolism]
+Abstract
+ PURPOSE OF REVIEW: So far, the tryptophan catabolites generated in the kynurenine pathway have been mainly studied in relation to oncologic and mental health disorders. The current review provides an update on the emerging biomedical interest for kynurenine pathway activity in the field of energy homeostasis and metabolic diseases.
+
+ RECENT FINDINGS: Kynurenine pathway enzymes are expressed in tissues relevant for energy homeostasis such as fat, skeletal muscle, liver and endocrine pancreas, blood vessel and heart, and are regulated by nutritional and inflammatory signals. Kynurenine pathway metabolites have been proposed as biomarkers for initiation and progression of atherosclerosis and diabetes. Exercise training activation of kynurenine pathway in skeletal muscles increases lipid metabolism and thermogenesis, and it limits weight gain, inflammation, insulin resistance, and glucose intolerance in rodents fed a high-fat diet. Manipulation of kynurenine pathway metabolism through administration of enzyme inhibitors or kynurenine pathway metabolites can serve as novel therapeutic strategy for atherosclerosis, obesity, glucose intolerance, or impaired insulin secretion.
+
+ SUMMARY: Although we are far from a complete understanding of the role of kynurenine pathway in the modulation of energy homeostasis, targeting kynurenine pathway harbors high potential to expand the range of therapies to prevent and treat metabolic diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 343-65-7 (Kynurenine). 8DUH1N11BX (Tryptophan).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fMCO.0000000000000529
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Liu&issn=1363-1950&title=Current+Opinion+in+Clinical+Nutrition+%26+Metabolic+Care&atitle=Emerging+role+for+kynurenines+in+metabolic+pathologies.&volume=22&issue=1&spage=82&epage=90&date=2019&doi=10.1097%2FMCO.0000000000000529&pmid=30407222&sid=OVID:medline
+
+<1871>
+Unique Identifier
+ 30406462
+Title
+ VEGF, Microvessel Density, and CD44 as Inflammation Markers in Peri-implant Healthy Mucosa, Peri-implant Mucositis, and Peri-implantitis: Impact of Age, Smoking, PPD, and Obesity.
+Source
+ Inflammation. 42(2):682-689, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lucarini G; Zizzi A; Rubini C; Ciolino F; Aspriello SD
+Author NameID
+ Lucarini, Guendalina; ORCID: http://orcid.org/0000-0003-3218-5620
+Authors Full Name
+ Lucarini, Guendalina; Zizzi, Antonio; Rubini, Corrado; Ciolino, Francesco; Aspriello, Simone Domenico.
+Institution
+ Lucarini, Guendalina. Department of Clinic and Molecular Sciences-Histology, Polytechnic University of Marche, Via Tronto 10/a-60126, Torrette, Ancona, Italy. guendalina.lucarini@univpm.it.
+ Zizzi, Antonio. Pathologic Anatomy and Histopathology Division, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marche, Ancona, Italy.
+ Rubini, Corrado. Pathologic Anatomy and Histopathology Division, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marche, Ancona, Italy.
+ Ciolino, Francesco. Private Dental Clinic, Osimo, Ancona, Italy.
+ Aspriello, Simone Domenico. Pathologic Anatomy and Histopathology Division, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marche, Ancona, Italy.
+ Aspriello, Simone Domenico. Private Dental Clinic, Pesaro, Italy.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Biomarkers/bl [Blood]
+ Female
+ Humans
+ *Hyaluronan Receptors/bl [Blood]
+ *Inflammation/bl [Blood]
+ Inflammation/di [Diagnosis]
+ Male
+ *Microvessels
+ Middle Aged
+ *Mucositis/bl [Blood]
+ Mucous Membrane/bs [Blood Supply]
+ Mucous Membrane/cy [Cytology]
+ *Mucous Membrane
+ Obesity
+ *Peri-Implantitis/bl [Blood]
+ Risk Factors
+ Smoking
+ *Vascular Endothelial Growth Factor A/bl [Blood]
+Keyword Heading
+ CD44
+ VEGF
+ inflammation markers
+ mucositis
+ peri-implant pocket depth
+ peri-implantitis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Several biologic processes affect the supporting peri-implant tissue leading to implant failure and complications, mainly referred to inflammation that is still poorly investigated in the peri-implant soft tissues. Our aim was to investigate in peri-implant healthy mucosa, peri-implant mucositis, and peri-implantitis the expression of some angiogenesis markers highly associated with inflammation, and evaluate its relationships with age, smoking, peri-implant pocket depth (PPD), and body max index (BMI). Moreover, we wanted to study the impact of these clinical parameters in the disease pathogenesis. Forty-eight total patients were recruited. Sixteen had at least one successfully osteointegrated dental implant (group A) and 32 had at least one osseointegrated implant in need of a peri-implant treatment for inflammatory/infectiveous reasons: precisely 16 for mucositis (group B) and 16 for peri-implantitis (group C). VEGF, CD34, and CD44 immunohistochemical expression was evaluated in the interproximal biopsies of marginal peri-implant tissue and correlated with the clinical parameters. A significant difference between groups in mean PPD was found, while the distribution by age, gender, smoking, and BMI resulted similar. Group C had significantly higher levels of VEGF, CD34, and CD44 expression compared to the other groups. VEGF, CD34, CD44, and peri-implant pocket depth were all positively correlated. Our study revealed that peri-implantitis is a condition characterized by unique and distinctive features. Our results supported that PPD has a great impact on the peri-implantitis and it is closely related to the inflammation marker expression. The identification of specific biomarkers might help in choosing distinct treatment approaches for target individuals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CD44 protein, human). 0 (Hyaluronan Receptors). 0 (VEGFA protein, human). 0 (Vascular Endothelial Growth Factor A).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs10753-018-0926-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lucarini&issn=0360-3997&title=Inflammation&atitle=VEGF%2C+Microvessel+Density%2C+and+CD44+as+Inflammation+Markers+in+Peri-implant+Healthy+Mucosa%2C+Peri-implant+Mucositis%2C+and+Peri-implantitis%3A+Impact+of+Age%2C+Smoking%2C+PPD%2C+and+Obesity.&volume=42&issue=2&spage=682&epage=689&date=2019&doi=10.1007%2Fs10753-018-0926-0&pmid=30406462&sid=OVID:medline
+
+<1872>
+Unique Identifier
+ 30398036
+Title
+ Serum R-Spondin 1 Is a New Surrogate Marker for Obesity and Insulin Resistance.
+Source
+ Diabetes & Metabolism Journal. 43(3):368-376, 2019 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kang YE; Kim JM; Yi HS; Joung KH; Lee JH; Kim HJ; Ku BJ
+Author NameID
+ Kang, Yea Eun; ORCID: https://orcid.org/0000-0002-2012-3716
+ Kim, Hyun Jin; ORCID: https://orcid.org/0000-0002-6760-4963
+ Ku, Bon Jeong; ORCID: https://orcid.org/0000-0002-3414-8949
+Authors Full Name
+ Kang, Yea Eun; Kim, Ji Min; Yi, Hyon Seung; Joung, Kyong Hye; Lee, Ju Hee; Kim, Hyun Jin; Ku, Bon Jeong.
+Institution
+ Kang, Yea Eun. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
+ Kim, Ji Min. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
+ Yi, Hyon Seung. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
+ Joung, Kyong Hye. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
+ Lee, Ju Hee. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
+ Kim, Hyun Jin. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. kimhj43@cnuh.co.kr.
+ Ku, Bon Jeong. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. bonjeong@cnu.ac.kr.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Thrombospondins/bl [Blood]
+Keyword Heading
+ Insulin resistance
+ Obesity
+ RSPO1 protein, human
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Recent in vivo studies indicated that R-spondin 1 (RSPO1) regulates food intake and increases insulin secretion, but its role in humans remains unknown. This study investigated the association between serum levels of RSPO1 and diverse metabolic parameters in humans.
+
+ METHODS: The study population consisted of 43 subjects with newly diagnosed diabetes mellitus, and 79 non-diabetic participants. Serum levels of RSPO1 were measured using the enzyme-linked immunosorbent assay. The relationships between circulating RSPO1 and diverse metabolic parameters were analyzed.
+
+ RESULTS: Circulating RSPO1 levels increased to a greater extent in the obese group than in the lean group. Moreover, serum levels of RSPO1 were higher in the insulin-resistant group than in the insulin-sensitive group. Serum levels of RSPO1 were significantly correlated with a range of metabolic parameters including body mass index, fasting C-peptide, homeostasis model assessment of insulin resistance index, and lipid profile. Moreover, levels were significantly associated with insulin resistance and obesity in non-diabetic subjects.
+
+ CONCLUSION: This study demonstrated the association between serum levels of RSPO1 and a range of metabolic parameters in humans. Serum levels of RSPO1 are significantly related to obesity and insulin resistance, although the precise mechanisms remain unknown. Copyright © 2019 Korean Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RSPO1 protein, human). 0 (Thrombospondins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.4093%2fdmj.2018.0066
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kang&issn=2233-6079&title=Diabetes+%26+Metabolism+Journal&atitle=Serum+R-Spondin+1+Is+a+New+Surrogate+Marker+for+Obesity+and+Insulin+Resistance.&volume=43&issue=3&spage=368&epage=376&date=2019&doi=10.4093%2Fdmj.2018.0066&pmid=30398036&sid=OVID:medline
+
+<1873>
+Unique Identifier
+ 30394901
+Title
+ Obesity and adult asthma: diagnostic and management challenges. [Review]
+Source
+ Current Opinion in Pulmonary Medicine. 25(1):44-50, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Grace J; Mohan A; Lugogo NL
+Authors Full Name
+ Grace, Jon; Mohan, Arjun; Lugogo, Njira Lucia.
+Institution
+ Grace, Jon. Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan.
+ Mohan, Arjun. Division of Pulmonary and Critical Care Medicine, East Carolina University, Greenville, North Carolina, USA.
+ Lugogo, Njira Lucia. Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan.
+MeSH Subject Headings
+ Adult
+ Asthma/co [Complications]
+ Asthma/di [Diagnosis]
+ Asthma/im [Immunology]
+ *Asthma/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ Humans
+ Immunity, Innate
+ *Inflammation/bl [Blood]
+ Inflammation/im [Immunology]
+ Lymphocytes
+ Obesity/co [Complications]
+ *Obesity/pp [Physiopathology]
+ Phenotype
+ Severity of Illness Index
+Abstract
+ PURPOSE OF REVIEW: Despite advances in our understanding of the obese asthma phenotype, heterogeneity and large gaps in knowledge have hindered significant advances in directed interventions.
+
+ RECENT FINDINGS: Obesity is associated with poorer asthma-related outcomes and increased risk of progression to severe asthma. Obese asthma is associated with variability in the expression of inflammatory markers, lung function impairments, and response to conventional and biologic therapies. In addition, traditional asthma biomarkers are not as reliable in obese patients. Several mechanistic pathways that uniquely impact asthma in obesity have been identified. Pathways involving innate lymphoid cells (ILC) type 2 (ILC-2) cells, surfactant protein-A, cell division control protein (CDC)42, interleukin (IL)-6, IL-17, and IL-33 are likely causal inflammatory pathways. Obesity also confounds lung function parameters making accurate diagnosis more challenging. As such, personalized asthma therapies directed towards obese asthma endotypes remain elusive.
+
+ SUMMARY: Obesity confounds traditional asthma biomarkers and lung function measurements, thus defining obese asthma endotypes remains challenging. Novel pathways are being identified and hold promise for future targeted therapies. However, we are in dire need of updated guidelines regarding asthma diagnosis in obese patients and the development of biomarkers that more accurately identify specific endotypes.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fMCP.0000000000000531
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Grace&issn=1070-5287&title=Current+Opinion+in+Pulmonary+Medicine&atitle=Obesity+and+adult+asthma%3A+diagnostic+and+management+challenges.&volume=25&issue=1&spage=44&epage=50&date=2019&doi=10.1097%2FMCP.0000000000000531&pmid=30394901&sid=OVID:medline
+
+<1874>
+Unique Identifier
+ 30383229
+Title
+ Acute Weight Loss Restores Dysregulated Circulating MicroRNAs in Individuals Who Are Obese.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 104(4):1239-1248, 2019 04 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Manning P; Munasinghe PE; Bellae Papannarao J; Gray AR; Sutherland W; Katare R
+Authors Full Name
+ Manning, Patrick; Munasinghe, Pujika Emani; Bellae Papannarao, Jayanthi; Gray, Andrew R; Sutherland, Wayne; Katare, Rajesh.
+Institution
+ Manning, Patrick. Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
+ Munasinghe, Pujika Emani. Department of Physiology, HeartOtago, School of Biomedical Science, University of Otago, Dunedin, New Zealand.
+ Bellae Papannarao, Jayanthi. Department of Physiology, HeartOtago, School of Biomedical Science, University of Otago, Dunedin, New Zealand.
+ Gray, Andrew R. Biostatistics Unit, Dunedin School of Medicine, Health Sciences, University of Otago, Dunedin, New Zealand.
+ Sutherland, Wayne. Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
+ Katare, Rajesh. Department of Physiology, HeartOtago, School of Biomedical Science, University of Otago, Dunedin, New Zealand.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ *Circulating MicroRNA/bl [Blood]
+ Circulating MicroRNA/ip [Isolation & Purification]
+ Down-Regulation
+ Female
+ Gene Expression Profiling
+ Humans
+ Middle Aged
+ New Zealand
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ *Obesity/th [Therapy]
+ Oligonucleotide Array Sequence Analysis
+ Real-Time Polymerase Chain Reaction
+ Treatment Outcome
+ Up-Regulation
+ *Weight Loss
+ *Weight Reduction Programs
+Abstract
+ CONTEXT: Obesity is a global epidemic and an independent risk factor for several diseases. miRNAs are gaining interest as early molecular regulators of various pathological processes.
+
+ OBJECTIVE: To examine the miRNA signatures in women who are obese and determine the response of miRNAs to acute weight loss.
+
+ METHODS: Plasma samples were collected from women who are obese (n = 80) before and after acute weight loss (mean, 7.2%). Plasma samples from age-matched lean volunteers (n = 80) were used as controls. Total RNA was extracted from the plasma samples and subjected to NanoString analysis of 822 miRNAs. The expression level of candidate miRNAs was validated in all participants using quantitative real-time PCR analysis.
+
+ RESULTS: NanoString analysis identified substantial dysregulation of 21 miRNAs in women who are obese that were associated with impaired glucose tolerance, senescence, cardiac hypertrophy, angiogenesis, inflammation, and cell death. Acute weight loss reversed the expression pattern of 18 of these miRNAs toward those seen in the lean control group. Furthermore, real-time PCR validation of all the samples for 13 miRNAs with at least twofold upregulation or downregulation confirmed substantial dysregulation of all the chosen miRNAs in women who are obese at baseline. After acute weight loss, the levels of seven miRNAs in women who are obese and who are lean were comparable, with no statistically significant evidence for differences between the two groups.
+
+ CONCLUSIONS: Our study has provided evidence that the circulating miRNAs associated with various disorders are dysregulated in women who are obese. We also found that seven of these miRNAs showed levels comparable to those in lean controls after acute weight loss in women who are obese. Copyright © 2019 Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Circulating MicroRNA).
+Publication Type
+ Clinical Trial, Phase IV. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1210%2fjc.2018-00684
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Manning&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Acute+Weight+Loss+Restores+Dysregulated+Circulating+MicroRNAs+in+Individuals+Who+Are+Obese.&volume=104&issue=4&spage=1239&epage=1248&date=2019&doi=10.1210%2Fjc.2018-00684&pmid=30383229&sid=OVID:medline
+
+<1875>
+Unique Identifier
+ 30378499
+Title
+ Vascular Damage in Obesity and Diabetes: Highlighting Links Between Endothelial Dysfunction and Metabolic Disease in Zebrafish and Man. [Review]
+Source
+ Current Vascular Pharmacology. 17(5):476-490, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wiggenhauser LM; Kroll J
+Authors Full Name
+ Wiggenhauser, Lucas Moritz; Kroll, Jens.
+Institution
+ Wiggenhauser, Lucas Moritz. Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
+ Kroll, Jens. Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/ge [Genetics]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ *Diabetic Angiopathies/bl [Blood]
+ Diabetic Angiopathies/et [Etiology]
+ Diabetic Angiopathies/ge [Genetics]
+ Diabetic Angiopathies/pp [Physiopathology]
+ Disease Models, Animal
+ *Endothelium, Vascular/me [Metabolism]
+ Endothelium, Vascular/pp [Physiopathology]
+ Humans
+ *Insulin/bl [Blood]
+ *Lipids/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ Risk Factors
+ Species Specificity
+ Zebrafish
+Keyword Heading
+ Endothelial function
+ danio rerio
+ diabetes mellitus
+ endothelial dysfunction
+ macrovascular complications
+ microvascular complications
+ obesity
+ zebrafish.
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Endothelial dysfunction is an initial pathophysiological mechanism of vascular damage and is further recognized as an independent predictor of negative prognosis in diabetes-induced micro- and macrovascular complications. Insight into the capability of zebrafish to model metabolic disease like obesity and type II diabetes has increased and new evidence on the induction of vascular pathologies in zebrafish through metabolic disease is available. Here, we raise the question, if zebrafish can be utilized to study the initial impairments of vascular complications in metabolic disorders. In this review, we focus on the advances made to develop models of obesity and type II diabetes in zebrafish, discuss the key points and characteristics of these models, while highlighting the available information linked to the development of endothelial dysfunction in zebrafish and man. We show that larval and adult zebrafish develop metabolic dysregulation in the settings of obesity and diabetes, exhibiting pathophysiological mechanisms, which mimic the human condition. The most important genes related to endothelial dysfunction are present in zebrafish and further display similar functions as in mammals. Several suggested contributors to endothelial dysfunction found in these models, namely hyperinsulinaemia, hyperglycaemia, hyperlipidaemia and hyperleptinaemia are highlighted and the available data from zebrafish are summarised. Many underlying processes of endothelial dysfunction in obesity and diabetes are fundamentally present in zebrafish and provide ground for the assumption, that zebrafish can develop endothelial dysfunction. Conservation of basic biological mechanisms is established for zebrafish, but focused investigation on the subject is now needed as validation and particularly more research is necessary to understand the differences between zebrafish and man. The available data demonstrate the relevance of zebrafish as a model for metabolic disease and their ability to become a proponent for the investigation of vascular damage in the settings of obesity and diabetes. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.2174%2f1570161116666181031101413
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wiggenhauser&issn=1570-1611&title=Current+Vascular+Pharmacology&atitle=Vascular+Damage+in+Obesity+and+Diabetes%3A+Highlighting+Links+Between+Endothelial+Dysfunction+and+Metabolic+Disease+in+Zebrafish+and+Man.&volume=17&issue=5&spage=476&epage=490&date=2019&doi=10.2174%2F1570161116666181031101413&pmid=30378499&sid=OVID:medline
+
+<1876>
+Unique Identifier
+ 30377838
+Title
+ Higher intakes of energy-adjusted dietary amino acids are inversely associated with obesity risk.
+Source
+ Amino Acids. 51(3):373-382, 2019 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Okekunle AP; Wu X; Feng R; Li Y; Sun C
+Author NameID
+ Okekunle, Akinkunmi Paul; ORCID: http://orcid.org/0000-0003-4825-4934
+Authors Full Name
+ Okekunle, Akinkunmi Paul; Wu, Xiaoyan; Feng, Rennan; Li, Ying; Sun, Changhao.
+Institution
+ Okekunle, Akinkunmi Paul. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
+ Wu, Xiaoyan. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
+ Feng, Rennan. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
+ Li, Ying. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China. liying_helen@163.com.
+ Sun, Changhao. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China. changhaosun2002@163.com.
+MeSH Subject Headings
+ Adult
+ Aged
+ Amino Acids/an [Analysis]
+ *Amino Acids/me [Metabolism]
+ Biomarkers/an [Analysis]
+ *Biomarkers/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ *Diet/ae [Adverse Effects]
+ *Energy Intake
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ Nutritional Status
+ *Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Prognosis
+ Risk Factors
+ Young Adult
+Keyword Heading
+ Amino acids
+ Dietary pattern
+ Obesity
+ Principal component analysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We assessed the relationship between energy-adjusted amino acids (EAA) intakes and obesity risk using data on nutrient intakes derived from the Chinese food composition tables to determine dietary intakes (DI) among 1109 obese and 3009 normal weight subjects. Dietary patterns (DP) were identified using principal component analysis, multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) of obesity risk by quartiles of EAA intakes was estimated using logistic regression with two-sided P < 0.05. Multivariable-adjusted OR and 95% CI for obesity risk were 1.00, 0.801 (0.573, 1.119), 0.718 (0.504, 1.024) and 0.532 (0.353, 0.803) P-trend = 0.003 across energy-adjusted quartiles of total AA intakes. Similarly, higher DI of 13 AA; isoleucine, leucine, valine, lysine, cysteine, phenylalanine, tyrosine, threonine, histidine, aspartic acid, glutamic acid, proline, and serine were associated with lower risk of obesity. Furthermore, six DP; 'Wheaten food and Rice', 'Fruit, Vegetables and Milk', 'Snack, Beverage and Ice cream', 'Potatoes, Soybean & Egg', 'Livestock & Poultry meat' and 'Fish' were identified. Multivariable-adjusted OR and 95% CI across quartiles of DP adherence for obesity risk were 1.00, 0.737 (0.535, 1.017), 0.563 (0.406, 0.779), 0.724 (0.518, 1.011) P-trend = 0.018 for 'Fruit, Vegetables and Milk', 1.00, 0.734 (0.531, 1.013), 0.841(0.609, 1.161), 0.657 (0.478, 0.904) P-trend = 0.027 for 'Potatoes, Soybean & Egg' and 1.00, 1.106 (0.791, 1.548), 1.367(0.975, 1.917), 1.953 (1.399, 2.726) P-trend = 0.000 for 'Fish'. Additionally, lower adherence to 'Snack, Beverage and Ice cream' and 'Fish' patterns is associated with a protective higher AA intake-obesity risk relationship. Energy-adjusted AA intakes were inversely associated with obesity risk, but the associations appear modifiable by DP adherence of respondents.
+Registry Number/Name of Substance
+ 0 (Amino Acids). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00726-018-2672-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Okekunle&issn=0939-4451&title=Amino+Acids&atitle=Higher+intakes+of+energy-adjusted+dietary+amino+acids+are+inversely+associated+with+obesity+risk.&volume=51&issue=3&spage=373&epage=382&date=2019&doi=10.1007%2Fs00726-018-2672-x&pmid=30377838&sid=OVID:medline
+
+<1877>
+Unique Identifier
+ 30369264
+Title
+ Global DNA methylation profiling in peripheral blood cells of South African women with gestational diabetes mellitus.
+Source
+ Biomarkers. 24(3):225-231, 2019 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dias S; Adam S; Van Wyk N; Rheeder P; Louw J; Pheiffer C
+Authors Full Name
+ Dias, Stephanie; Adam, Sumaiya; Van Wyk, Nastasja; Rheeder, Paul; Louw, Johan; Pheiffer, Carmen.
+Institution
+ Dias, Stephanie. a South African Medical Research Council, Biomedical Research and Innovation Platform (BRIP), Tygerberg, South Africa.
+ Dias, Stephanie. b Department of Obstetrics and Gynecology, University of Pretoria, Pretoria, South Africa.
+ Adam, Sumaiya. b Department of Obstetrics and Gynecology, University of Pretoria, Pretoria, South Africa.
+ Van Wyk, Nastasja. a South African Medical Research Council, Biomedical Research and Innovation Platform (BRIP), Tygerberg, South Africa.
+ Rheeder, Paul. c Department of Internal Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
+ Louw, Johan. a South African Medical Research Council, Biomedical Research and Innovation Platform (BRIP), Tygerberg, South Africa.
+ Louw, Johan. d Department of Biochemistry and Microbiology, University of Zululand, Kwa-Dlangezwa, South Africa.
+ Pheiffer, Carmen. a South African Medical Research Council, Biomedical Research and Innovation Platform (BRIP), Tygerberg, South Africa.
+ Pheiffer, Carmen. e Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Black People/ge [Genetics]
+ Blood Cells
+ *DNA Methylation/ge [Genetics]
+ Diabetes, Gestational/bl [Blood]
+ *Diabetes, Gestational/ge [Genetics]
+ Diabetes, Gestational/pa [Pathology]
+ Female
+ Humans
+ Insulin/bl [Blood]
+ Obesity/bl [Blood]
+ *Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ Pregnancy
+ South Africa
+Keyword Heading
+ Gestational diabetes mellitus
+ South Africa
+ biomarker
+ global DNA methylation
+ obesity
+ peripheral blood cells
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background/Objective: Recently, several studies have reported that DNA methylation changes in tissue are reflected in blood, sparking interest in the potential use of global DNA methylation as a biomarker for gestational diabetes mellitus (GDM). This study investigated whether global DNA methylation is associated with GDM in South African women. Methods: Global DNA methylation was quantified in peripheral blood cells of women with (n = 63) or without (n = 138) GDM using the MDQ1 Imprint R DNA Quantification Kit. Results: Global DNA methylation levels were not different between women with or without GDM and were not associated with fasting glucose or insulin concentrations. However, levels were 18% (p = 0.012) higher in obese compared to non-obese pregnant women and inversely correlated with serum adiponectin concentrations (p = 0.005). Discussion: Contrary to our hypothesis, global DNA methylation was not associated with GDM in our population. These preliminary findings suggest that despite being a robust marker of overall genomic methylation that offers opportunities as a biomarker, global DNA methylation profiling may not offer the resolution required to detect methylation differences in the peripheral blood cells of women with GDM. Moreover, global DNA methylation in peripheral blood cells may not reflect changes in placental tissue. Further studies in a larger sample are required to explore the candidacy of a more targeted approach using gene-specific methylation as a biomarker for GDM in our population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Insulin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f1354750X.2018.1539770
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dias&issn=1354-750X&title=Biomarkers&atitle=Global+DNA+methylation+profiling+in+peripheral+blood+cells+of+South+African+women+with+gestational+diabetes+mellitus.&volume=24&issue=3&spage=225&epage=231&date=2019&doi=10.1080%2F1354750X.2018.1539770&pmid=30369264&sid=OVID:medline
+
+<1878>
+Unique Identifier
+ 30362228
+Title
+ Can obesity in a major depressive episode be considered as a biomarker for bipolar spectrum disorders?.
+Source
+ Bipolar Disorders. 21(1):11-12, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gao K
+Author NameID
+ Gao, Keming; ORCID: https://orcid.org/0000-0003-1130-2461
+Authors Full Name
+ Gao, Keming.
+Institution
+ Gao, Keming. Mood and Anxiety Clinic in the Mood Disorders Program of the Department of Psychiatry, University Hospitals Cleveland Medical Center/Case Western Reserve University School of Medicine, Cleveland, Ohio.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Biomarkers
+ *Bipolar Disorder
+ *Depressive Disorder, Major
+ Humans
+ Obesity
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Comment.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fbdi.12705
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gao&issn=1398-5647&title=Bipolar+Disorders&atitle=Can+obesity+in+a+major+depressive+episode+be+considered+as+a+biomarker+for+bipolar+spectrum+disorders%3F.&volume=21&issue=1&spage=11&epage=12&date=2019&doi=10.1111%2Fbdi.12705&pmid=30362228&sid=OVID:medline
+
+<1879>
+Unique Identifier
+ 30346647
+Title
+ Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini-review. [Review]
+Source
+ Clinical Endocrinology. 90(1):47-55, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yuan D; Wu BJ; Henry A; Rye KA; Ong KL
+Author NameID
+ Ong, Kwok Leung; ORCID: https://orcid.org/0000-0001-7229-7614
+Authors Full Name
+ Yuan, Daniel; Wu, Ben J; Henry, Amanda; Rye, Kerry-Anne; Ong, Kwok Leung.
+Institution
+ Yuan, Daniel. School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
+ Wu, Ben J. School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
+ Henry, Amanda. School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
+ Henry, Amanda. Department of Women's and Children's Health, St George Hospital, Sydney, New South Wales, Australia.
+ Rye, Kerry-Anne. School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
+ Ong, Kwok Leung. School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes, Gestational/bl [Blood]
+ *Diabetes, Gestational/et [Etiology]
+ Female
+ Fibroblast Growth Factors/bl [Blood]
+ *Fibroblast Growth Factors/ph [Physiology]
+ Humans
+ Insulin Resistance
+ Obesity/bl [Blood]
+ Pregnancy
+Keyword Heading
+ biomarkers
+ diabetes mellitus
+ fibroblast growth factor 21
+ gestational diabetes
+ insulin resistance
+ pregnancy
+ risk factors
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first diagnosis during pregnancy, but not to the level of being diagnostic for diabetes in a nonpregnant adult. In GDM, whole-body insulin-dependent glucose disposal decreases by 40%-60% which necessitates a 200%-250% increase in insulin secretion to maintain normoglycaemia. GDM develops when a pregnant woman does not produce sufficient insulin to compensate for the reduced glucose disposal. Fibroblast growth factor 21 (FGF21) is a hormone that is expressed predominantly in the liver, but also in other metabolically active tissues such as pancreas, skeletal muscle and adipose tissue. In animals, FGF21 lowers blood glucose levels and inhibits glucagon secretion. In humans, circulating FGF21 levels are increased in insulin-resistant morbidities such as obesity and type 2 diabetes mellitus (T2DM). An elevated FGF21 level is also an independent predictor of T2DM. GDM and T2DM are proposed to have similar underlying pathophysiologies, raising the question of whether a similar relationship exists between FGF21 and GDM as it does with T2DM. There are a limited number of studies investigating FGF21 levels in patients with GDM. Moreover, recent clinical trials investigating the therapeutic potential of FGF21 have highlighted a major gap in our understanding of the biology of FGF21. This review evaluates what is currently known about FGF21 and GDM and highlights important gaps that warrant further research. Copyright © 2018 John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (fibroblast growth factor 21). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fcen.13881
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yuan&issn=0300-0664&title=Clinical+Endocrinology&atitle=Role+of+fibroblast+growth+factor+21+in+gestational+diabetes+mellitus%3A+A+mini-review.&volume=90&issue=1&spage=47&epage=55&date=2019&doi=10.1111%2Fcen.13881&pmid=30346647&sid=OVID:medline
+
+<1880>
+Unique Identifier
+ 30343042
+Title
+ Assessment of metabolic and hormonal profiles and striatal dopamine D2 receptor expression following continuous or scheduled high-fat or high-sucrose diet in rats.
+Source
+ Pharmacological Reports: PR. 71(1):1-12, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rospond B; Sadakierska-Chudy A; Kazek G; Krosniak M; Bystrowska B; Filip M
+Authors Full Name
+ Rospond, Bartlomiej; Sadakierska-Chudy, Anna; Kazek, Grzegorz; Krosniak, Miroslaw; Bystrowska, Beata; Filip, Malgorzata.
+Institution
+ Rospond, Bartlomiej. Chair of Toxicology, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, Poland.
+ Sadakierska-Chudy, Anna. Institute of Pharmacology, Polish Academy of Sciences, Department of Drug Addiction Pharmacology, Krakow, Poland.
+ Kazek, Grzegorz. Chair of Neurobiology, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, Poland.
+ Krosniak, Miroslaw. Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, Poland.
+ Bystrowska, Beata. Chair of Toxicology, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, Poland.
+ Filip, Malgorzata. Institute of Pharmacology, Polish Academy of Sciences, Department of Drug Addiction Pharmacology, Krakow, Poland. Electronic address: mal.fil@if-pan.krakow.pl.
+MeSH Subject Headings
+ Animal Nutritional Physiological Phenomena
+ Animals
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Cholesterol/bl [Blood]
+ *Corpus Striatum/me [Metabolism]
+ Corpus Striatum/pp [Physiopathology]
+ *Diet, High-Fat
+ *Dietary Sucrose
+ Disease Models, Animal
+ Energy Intake
+ *Energy Metabolism
+ Feeding Behavior
+ Ghrelin/bl [Blood]
+ *Hormones/bl [Blood]
+ Leptin/bl [Blood]
+ Male
+ Nutritional Status
+ *Obesity/bl [Blood]
+ Obesity/et [Etiology]
+ Obesity/pp [Physiopathology]
+ Obesity/px [Psychology]
+ Rats, Wistar
+ Receptors, Dopamine D2/ge [Genetics]
+ *Receptors, Dopamine D2/me [Metabolism]
+ Signal Transduction
+ Time Factors
+ Triglycerides/bl [Blood]
+ Weight Gain
+Keyword Heading
+ Binge eating
+ Diet-induced obesity
+ Dopamine D2 receptors
+ Hormone
+ Metabolic profile
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity has reached global epidemic proportions and is associated with serious medical comorbidities and economic consequences. In this preclinical study, we characterized how the palatable diet changed food intake pattern, caloric intake, metabolic profile and hormone levels. We also evaluated the expression of dopamine D2 receptors in the rat striatum.
+
+ METHODS: Male Wistar rats were fed with either high-fat or high-sucrose diet for 5 weeks according to different feeding regimes: ad libitum access or scheduled for a 2-h period each day without caloric restriction during the remainder of the day.
+
+ RESULTS: Both diets resulted in an enhancement in caloric intake and total body weight. Post-meal data showed that high-fat diet increased cholesterol, triglycerides and glucose concentrations. Animals fed on high sucrose diet were only hyperglycemic. High-fat diet schedules resulted in the enhancement of leptin concentrations, while increases in blood levels of ghrelin were noted after intermitted high-fat or continuous high-sucrose diet. Finally, we report that only ad libitum high-sucrose evoked a significant enhancement of the dopamine D2 receptor protein level and a reduction in the D2 mRNA and receptor affinity in the rat striatum. Independently of the diet type, a similar reduction in dopamine D2 receptor affinity (decrease in KD value) was found in the striatum of rats with intermittent food access.
+
+ CONCLUSION: The findings provide a better understanding of eating disorders and indicate that diet composition leading to obesity induces distinct changes in dopamine D2 receptor signaling in the striatum. Copyright © 2018 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (DRD2 protein, rat). 0 (Dietary Sucrose). 0 (Ghrelin). 0 (Hormones). 0 (Leptin). 0 (Receptors, Dopamine D2). 0 (Triglycerides). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.pharep.2018.09.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rospond&issn=1734-1140&title=Pharmacological+Reports%3A+PR&atitle=Assessment+of+metabolic+and+hormonal+profiles+and+striatal+dopamine+D2+receptor+expression+following+continuous+or+scheduled+high-fat+or+high-sucrose+diet+in+rats.&volume=71&issue=1&spage=1&epage=12&date=2019&doi=10.1016%2Fj.pharep.2018.09.005&pmid=30343042&sid=OVID:medline
+
+<1881>
+Unique Identifier
+ 30339734
+Title
+ Adipose tissue expression of CCL19 chemokine is positively associated with insulin resistance.
+Source
+ Diabetes/Metabolism Research Reviews. 35(2):e3087, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kochumon S; Al-Rashed F; Abu-Farha M; Devarajan S; Tuomilehto J; Ahmad R
+Author NameID
+ Abu-Farha, Mohamed; ORCID: https://orcid.org/0000-0001-8357-1252
+ Ahmad, Rasheed; ORCID: https://orcid.org/0000-0001-5746-0743
+Authors Full Name
+ Kochumon, Shihab; Al-Rashed, Fatema; Abu-Farha, Mohamed; Devarajan, Sriraman; Tuomilehto, Jaakko; Ahmad, Rasheed.
+Institution
+ Kochumon, Shihab. Immunology Unit, Dasman Diabetes Institute, Kuwait, Kuwait.
+ Al-Rashed, Fatema. Immunology Unit, Dasman Diabetes Institute, Kuwait, Kuwait.
+ Abu-Farha, Mohamed. Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Kuwait, Kuwait.
+ Devarajan, Sriraman. National Dasman Diabetes BioBank, Dasman Diabetes Institute, Kuwait, Kuwait.
+ Tuomilehto, Jaakko. Immunology Unit, Dasman Diabetes Institute, Kuwait, Kuwait.
+ Tuomilehto, Jaakko. Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Kuwait, Kuwait.
+ Tuomilehto, Jaakko. National Dasman Diabetes BioBank, Dasman Diabetes Institute, Kuwait, Kuwait.
+ Ahmad, Rasheed. Immunology Unit, Dasman Diabetes Institute, Kuwait, Kuwait.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Adult
+ Biomarkers/an [Analysis]
+ Case-Control Studies
+ Chemokine CCL19/ge [Genetics]
+ *Chemokine CCL19/me [Metabolism]
+ Female
+ Follow-Up Studies
+ Humans
+ *Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ *Insulin Resistance
+ Male
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prognosis
+ *Thinness
+Keyword Heading
+ CCL19
+ adipose tissue
+ insulin resistance
+ metabolic inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Chemokines produced by adipose tissue (AT) are involved in the development of chronic low-grade inflammation in obese humans and rodents. AT CCL19 expression in obesity and its association with metabolic inflammation and insulin resistance are poorly understood. This study aimed to investigate the effects of CCL19 gene expression on inflammatory markers in subcutaneous AT and insulin resistance.
+
+ METHODS: Subcutaneous adipose samples were collected from 56 non-diabetic (26-obese, 21-overweight, and 9-lean) individuals. Expression of CCL19 and inflammatory markers was determined using real-time RT-PCR. Plasma C-reactive protein (CRP) and adiponectin were measured by ELISA. Insulin sensitivity was assessed using homeostasis model assessment index (HOMA).
+
+ RESULTS: CCL19 expression was significantly higher in obese compared with lean individuals (P < 0.034). The elevated expression of CCL19 associated positively with body mass index (r = 0.253; P = 0.049). CCL19 expression correlated positively with IL-8 (r = 0.39; P = 0.006), IL-12 (r = 0.43; P = 0.003), IP-10 (r = 0.25; P = 0.07), CCL5 (r = 0.37; P = 0.011), CCR2 (r = 0.44; P = 0.001), and CCR5 (r = 0.35; P = 0.009). Additionally, CCL19 was positively correlated with triglycerides (TG: r = 0.41; P = 0.001), fasting blood glucose (FBG: r = 0.49; P < 0.0001), glycated haemoglobin (HbA1c: r = 0.396; P = 0.001), and CRP (r = 0.387; P = 0.019) whereas it had negative association with HDL cholesterol (r = -0.282; P = 0.035) and adiponectin (-0.393; P = 0.019). Notably, HOMA-IR correlated positively with CCL19 (r = 0.38; P = 0.01). In multiple regression analysis, CCL19 is an independent predictor of IL-8 and IL-12.
+
+ CONCLUSIONS: These data demonstrate that increased AT expression of CCL19 in obesity may represent a molecular link between metabolic inflammation and insulin resistance. Copyright © 2018 The Authors. Diabetes/Metabolism Research and Reviews Published by John Wiley & Sons Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CCL19 protein, human). 0 (Chemokine CCL19).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fdmrr.3087
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kochumon&issn=1520-7552&title=Diabetes%2FMetabolism+Research+Reviews&atitle=Adipose+tissue+expression+of+CCL19+chemokine+is+positively+associated+with+insulin+resistance.&volume=35&issue=2&spage=e3087&epage=&date=2019&doi=10.1002%2Fdmrr.3087&pmid=30339734&sid=OVID:medline
+
+<1882>
+Unique Identifier
+ 30333223
+Title
+ Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study.
+Source
+ Cancer Epidemiology, Biomarkers & Prevention. 28(1):76-82, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Himbert C; Ose J; Nattenmuller J; Warby CA; Holowatyj AN; Bohm J; Lin T; Haffa M; Gigic B; Hardikar S; Scherer D; Zielske L; Schrotz-King P; Kolsch T; Siegel EM; Shibata D; Ulrich A; Schneider M; Hursting SD; Kauczor HU; Ulrich CM
+Author NameID
+ Ose, Jennifer; ORCID: https://orcid.org/0000-0002-2030-9676
+ Nattenmuller, Johanna; ORCID: https://orcid.org/0000-0003-4032-378X
+ Holowatyj, Andreana N; ORCID: https://orcid.org/0000-0001-8001-8793
+ Schrotz-King, Petra; ORCID: https://orcid.org/0000-0003-4339-3492
+Authors Full Name
+ Himbert, Caroline; Ose, Jennifer; Nattenmuller, Johanna; Warby, Christy A; Holowatyj, Andreana N; Bohm, Jurgen; Lin, Tengda; Haffa, Mariam; Gigic, Biljana; Hardikar, Sheetal; Scherer, Dominique; Zielske, Lin; Schrotz-King, Petra; Kolsch, Torsten; Siegel, Erin M; Shibata, David; Ulrich, Alexis; Schneider, Martin; Hursting, Stephen D; Kauczor, Hans-Ulrich; Ulrich, Cornelia M.
+Institution
+ Himbert, Caroline. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Himbert, Caroline. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Ose, Jennifer. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Ose, Jennifer. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Nattenmuller, Johanna. Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany.
+ Warby, Christy A. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Warby, Christy A. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Holowatyj, Andreana N. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Holowatyj, Andreana N. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Bohm, Jurgen. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Bohm, Jurgen. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Lin, Tengda. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Lin, Tengda. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Haffa, Mariam. National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
+ Gigic, Biljana. Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
+ Hardikar, Sheetal. Huntsman Cancer Institute, Salt Lake City, Utah.
+ Hardikar, Sheetal. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+ Hardikar, Sheetal. Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
+ Scherer, Dominique. Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
+ Zielske, Lin. National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
+ Schrotz-King, Petra. National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
+ Kolsch, Torsten. Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
+ Siegel, Erin M. H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
+ Shibata, David. University of Tennessee Health Science Center, Memphis, Tennessee.
+ Ulrich, Alexis. Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
+ Schneider, Martin. Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
+ Hursting, Stephen D. The University of North Carolina, Chapel Hill, North Carolina.
+ Kauczor, Hans-Ulrich. Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany.
+ Ulrich, Cornelia M. Huntsman Cancer Institute, Salt Lake City, Utah. neli.ulrich@hci.utah.edu.
+ Ulrich, Cornelia M. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ Colorectal Neoplasms/bs [Blood Supply]
+ *Colorectal Neoplasms/di [Diagnosis]
+ Colorectal Neoplasms/im [Immunology]
+ Colorectal Neoplasms/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Inflammation/co [Complications]
+ *Intra-Abdominal Fat/pa [Pathology]
+ Male
+ Middle Aged
+ *Neovascularization, Pathologic/co [Complications]
+ Obesity/co [Complications]
+ Prognosis
+ Risk Factors
+ *Subcutaneous Fat/pa [Pathology]
+ Young Adult
+Abstract
+ BACKGROUND: Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients with colorectal cancer.
+
+ METHODS: Preoperative serum samples and computed tomography scans were obtained from 188 patients diagnosed with primary invasive stage I-IV colorectal cancer enrolled in the ColoCare Study. Adiposity was assessed by area-based quantification of VFA, SFA, and VFA:SFA ratio on spinal levels L3/L4 and L4/L5. Circulating levels of inflammation (CRP, SAA, sICAM-1, and sVCAM-1) and angiogenesis (VEGF-A and VEGF-D) were assessed from patient sera on the Meso Scale Discovery platform. Partial correlations and regression analyses, adjusted for age, sex, and tumor stage, were performed.
+
+ RESULTS: VFA was moderately correlated with CRP and SAA (CRP: L3/L4 and L4/L5:r = 0.21, P = 0.01; SAA: L3/L4:r = 0.17, P = 0.04). The correlation between SFA and the measured biomarkers were weak (r <= 0.13, not significant). The ratio of VFA:SFA at L3/L4 was moderately correlated with VEGF-A (r = 0.28, P = 0.0008) and SAA (r = 0.24, P = 0.006), and less so with CRP (r = 0.18, P = 0.04) and sICAM-1 (r = 0.18, P = 0.04). Similar correlations were found for the VFA:SFA ratio at L4/L5.
+
+ CONCLUSIONS: We observed an association between visceral adiposity and biomarkers of inflammation and angiogenesis in colorectal cancer. In particular, the VFA:SFA ratio was correlated with circulating levels of the proangiogenic biomarker VEGF-A.
+
+ IMPACT: Our findings support a direct association of visceral adipose tissue with inflammatory and angiogenic processes, which play fundamental roles in the development and progression of colorectal cancer. Copyright ©2018 American Association for Cancer Research.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1158%2f1055-9965.EPI-18-0654
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Himbert&issn=1055-9965&title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&atitle=Body+Fatness%2C+Adipose+Tissue+Compartments%2C+and+Biomarkers+of+Inflammation+and+Angiogenesis+in+Colorectal+Cancer%3A+The+ColoCare+Study.&volume=28&issue=1&spage=76&epage=82&date=2019&doi=10.1158%2F1055-9965.EPI-18-0654&pmid=30333223&sid=OVID:medline
+
+<1883>
+Unique Identifier
+ 30317580
+Title
+ Glucose intolerance in monosodium glutamate obesity is linked to hyperglucagonemia and insulin resistance in alpha cells.
+Source
+ Journal of Cellular Physiology. 234(5):7019-7031, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Araujo TR; da Silva JA; Vettorazzi JF; Freitas IN; Lubaczeuski C; Magalhaes EA; Silva JN; Ribeiro ES; Boschero AC; Carneiro EM; Bonfleur ML; Ribeiro RA
+Author NameID
+ Ribeiro, Rosane Aparecida; ORCID: https://orcid.org/0000-0003-0839-8124
+Authors Full Name
+ Araujo, Thiago R; da Silva, Joel A; Vettorazzi, Jean F; Freitas, Israelle N; Lubaczeuski, Camila; Magalhaes, Emily A; Silva, Juliana N; Ribeiro, Elane S; Boschero, Antonio C; Carneiro, Everardo M; Bonfleur, Maria L; Ribeiro, Rosane Aparecida.
+Institution
+ Araujo, Thiago R. Campus UFRJ-Macae, Universidade Federal do R io de Janeiro, Macae, Brazil.
+ da Silva, Joel A. Campus UFRJ-Macae, Universidade Federal do R io de Janeiro, Macae, Brazil.
+ Vettorazzi, Jean F. Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil.
+ Freitas, Israelle N. Campus UFRJ-Macae, Universidade Federal do R io de Janeiro, Macae, Brazil.
+ Lubaczeuski, Camila. Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil.
+ Magalhaes, Emily A. Campus UFRJ-Macae, Universidade Federal do R io de Janeiro, Macae, Brazil.
+ Silva, Juliana N. Campus UFRJ-Macae, Universidade Federal do R io de Janeiro, Macae, Brazil.
+ Ribeiro, Elane S. Campus UFRJ-Macae, Universidade Federal do R io de Janeiro, Macae, Brazil.
+ Boschero, Antonio C. Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil.
+ Carneiro, Everardo M. Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil.
+ Bonfleur, Maria L. Centro de Ciencias Biologicas e da Saude, Universidade Estadual do Oeste do Parana (UNIOESTE), Cascavel, Brazil.
+ Ribeiro, Rosane Aparecida. Campus UFRJ-Macae, Universidade Federal do R io de Janeiro, Macae, Brazil.
+MeSH Subject Headings
+ Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Cyclic AMP Response Element-Binding Protein/me [Metabolism]
+ Cyclic AMP-Dependent Protein Kinases/me [Metabolism]
+ Disease Models, Animal
+ *Glucagon/bl [Blood]
+ *Glucagon-Secreting Cells/me [Metabolism]
+ *Glucose Intolerance/bl [Blood]
+ Glucose Intolerance/ci [Chemically Induced]
+ Glucose Intolerance/pp [Physiopathology]
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ Liver/me [Metabolism]
+ Male
+ Mice
+ *Obesity/bl [Blood]
+ Obesity/ci [Chemically Induced]
+ Obesity/pp [Physiopathology]
+ Phosphoenolpyruvate Carboxykinase (ATP)/me [Metabolism]
+ Phosphorylation
+ *Sodium Glutamate
+ TOR Serine-Threonine Kinases/me [Metabolism]
+Keyword Heading
+ glucagon secretion
+ hepatic glucose output
+ lipolysis
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity predisposes to glucose intolerance and type 2 diabetes (T2D). This disease is often characterized by insulin resistance, changes in insulin clearance, and beta-cell dysfunction. However, studies indicate that, for T2D development, disruptions in glucagon physiology also occur. Herein, we investigated the involvement of glucagon in impaired glycemia control in monosodium glutamate (MSG)-obese mice. Male Swiss mice were subcutaneously injected daily, during the first 5 days after birth, with MSG (4 mg/g body weight [BW]) or saline (1.25 mg/g BW). At 90 days of age, MSG-obese mice were hyperglycemic, hyperinsulinemic, and hyperglucagonemic and had lost the capacity to increase their insulin/glucagon ratio when transitioning from the fasting to fed state, exacerbating hepatic glucose output. Furthermore, hepatic protein expressions of phosphorylated (p)-protein kinase A (PKA) and cAMP response element-binding protein (pCREB), and of phosphoenolpyruvate carboxykinase (PEPCK) enzyme were higher in fed MSG, before and after glucagon stimulation. Increased pPKA and phosphorylated hormone-sensitive lipase content were also observed in white fat of MSG. MSG islets hypersecreted glucagon in response to 11.1 and 0.5 mmol/L glucose, a phenomenon that persisted in the presence of insulin. Additionally, MSG alpha cells were hypertrophic displaying increased alpha-cell mass and immunoreactivity to phosphorylated mammalian target of rapamycin (pmTOR) protein. Therefore, severe glucose intolerance in MSG-obese mice was associated with increased hepatic glucose output, in association with hyperglucagonemia, caused by the refractory actions of glucose and insulin in alpha cells and via an effect that may be due to enhanced mTOR activation. Copyright © 2018 Wiley Periodicals, Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Creb1 protein, mouse). 0 (Cyclic AMP Response Element-Binding Protein). 0 (Insulin). 9007-92-5 (Glucagon). EC 2-7-1-1 (mTOR protein, mouse). EC 2-7-11-1 (TOR Serine-Threonine Kinases). EC 2-7-11-11 (Cyclic AMP-Dependent Protein Kinases). EC 4-1-1-49 (Phosphoenolpyruvate Carboxykinase (ATP)). W81N5U6R6U (Sodium Glutamate).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fjcp.27455
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Araujo&issn=0021-9541&title=Journal+of+Cellular+Physiology&atitle=Glucose+intolerance+in+monosodium+glutamate+obesity+is+linked+to+hyperglucagonemia+and+insulin+resistance+in+alpha+cells.&volume=234&issue=5&spage=7019&epage=7031&date=2019&doi=10.1002%2Fjcp.27455&pmid=30317580&sid=OVID:medline
+
+<1884>
+Unique Identifier
+ 30312135
+Title
+ Effect of a Fucoidan Extract on Insulin Resistance and Cardiometabolic Markers in Obese, Nondiabetic Subjects: A Randomized, Controlled Trial.
+Source
+ Journal of Alternative & Complementary Medicine. 25(3):346-352, 2019 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wright CM; Bezabhe W; Fitton JH; Stringer DN; Bereznicki LRE; Peterson GM
+Authors Full Name
+ Wright, Cameron M; Bezabhe, Woldesellassie; Fitton, J Helen; Stringer, Damien N; Bereznicki, Luke R E; Peterson, Gregory M.
+Institution
+ Wright, Cameron M. 1 School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Australia.
+ Wright, Cameron M. 2 Health Systems and Health Economics, Faculty of Health Sciences, School of Public Health, Curtin University, Perth, Western Australia.
+ Bezabhe, Woldesellassie. 1 School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Australia.
+ Fitton, J Helen. 3 Marinova, Hobart, Australia.
+ Stringer, Damien N. 3 Marinova, Hobart, Australia.
+ Bereznicki, Luke R E. 1 School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Australia.
+ Peterson, Gregory M. 1 School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Australia.
+MeSH Subject Headings
+ Adult
+ Australia
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Blood Glucose/de [Drug Effects]
+ Blood Pressure/de [Drug Effects]
+ Blood Pressure/ph [Physiology]
+ Female
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Obesity/pp [Physiopathology]
+ Polysaccharides/ae [Adverse Effects]
+ Polysaccharides/pd [Pharmacology]
+ *Polysaccharides/tu [Therapeutic Use]
+Keyword Heading
+ fucoidan
+ glucose tolerance
+ obesity
+ prediabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: To determine whether a fucoidan extract reduced insulin resistance and/or altered other cardiometabolic markers in an obese, nondiabetic population.
+
+ DESIGN: Single-site, double-blinded, placebo-controlled, randomized controlled trial.
+
+ SETTING/LOCATION: Hobart, Tasmania, Australia.
+
+ SUBJECTS: Eligible subjects were obese, with no history of diabetes, and ages between 18 and 65 years.
+
+ INTERVENTIONS: Subjects were randomly assigned, in even blocks of 10, to either active fucoidan 500 mg or placebo capsules twice daily for 90 days, with identical measurements performed at baseline and follow-up.
+
+ OUTCOME MEASURES: The primary outcome was insulin resistance, defined by the homeostasis model of assessment (HOMA) values. Secondary outcomes were lipid profile, glycosylated hemoglobin, urea electrolytes and creatinine, liver function tests, full/complete blood count, fasting insulin, fasting glucose, quantitative insulin sensitivity check index, glucose area under the curve, weight, body mass index, waist circumference, and systolic and diastolic blood pressure. The trial was registered with the Australian New Zealand Clinical Trial Registry (ACTRN12614000495628) and the Therapeutic Goods Administration (2014/0348), and was funded by Marinova Pty. Ltd.
+
+ RESULTS: There were no differences in the 90-day outcome measures between placebo and active treatment in the intention-to-treat-analysis (n = 35 for active, n = 37 for placebo). The mean change in HOMA scores was 0 for the placebo and -0.1 for the active groups (p = 0.73). Self-reported adherence was high, consistent with capsule counting at the conclusion of the trial.
+
+ CONCLUSIONS: Fucoidan taken twice daily for a period of 90 days did not markedly affect insulin resistance or other measured parameters of cardiometabolic health in an obese, nondiabetic cohort. This could be due to an intrinsic lack of efficacy, lower than measured adherence, or because longer therapy and/or higher baseline insulin resistance are required to exert a significant effect.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). 0 (Polysaccharides). 9072-19-9 (fucoidan).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1089%2facm.2018.0189
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wright&issn=1075-5535&title=Journal+of+Alternative+%26+Complementary+Medicine&atitle=Effect+of+a+Fucoidan+Extract+on+Insulin+Resistance+and+Cardiometabolic+Markers+in+Obese%2C+Nondiabetic+Subjects%3A+A+Randomized%2C+Controlled+Trial.&volume=25&issue=3&spage=346&epage=352&date=2019&doi=10.1089%2Facm.2018.0189&pmid=30312135&sid=OVID:medline
+
+<1885>
+Unique Identifier
+ 30306222
+Title
+ Acute continuous moderate-intensity exercise, but not low-volume high-intensity interval exercise, attenuates postprandial suppression of circulating osteocalcin in young overweight and obese adults.
+Source
+ Osteoporosis International. 30(2):403-410, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Parker L; Shaw CS; Byrnes E; Stepto NK; Levinger I
+Author NameID
+ Parker, L; ORCID: http://orcid.org/0000-0002-5372-1851
+Authors Full Name
+ Parker, L; Shaw, C S; Byrnes, E; Stepto, N K; Levinger, I.
+Institution
+ Parker, L. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. lewan.parker@deakin.edu.au.
+ Parker, L. Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia. lewan.parker@deakin.edu.au.
+ Shaw, C S. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
+ Shaw, C S. Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia.
+ Byrnes, E. PathWest QEII Medical Centre, Perth, Australia.
+ Stepto, N K. Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia.
+ Stepto, N K. Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne, Melbourne, Australia.
+ Stepto, N K. Monash Centre of Health Research and Implementation (MCHRI), School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia.
+ Levinger, I. Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia.
+ Levinger, I. Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne, Melbourne, Australia.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Bone Remodeling/ph [Physiology]
+ Eating/ph [Physiology]
+ Exercise/ph [Physiology]
+ Exercise Test
+ *Exercise Therapy/mt [Methods]
+ Female
+ Humans
+ Insulin/bl [Blood]
+ Male
+ Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ Obesity/rh [Rehabilitation]
+ *Osteocalcin/bl [Blood]
+ *Overweight/bl [Blood]
+ Overweight/pp [Physiopathology]
+ Overweight/rh [Rehabilitation]
+ Postprandial Period/ph [Physiology]
+Keyword Heading
+ Bone metabolism
+ Glycemic control
+ HIIT
+ Osteoblast
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Bone remodeling markers (BRMs) are suppressed following the consumption of a meal. Our findings indicate that a single session of continuous moderate-intensity exercise, but not low-volume high-intensity interval exercise, performed 1 h after a meal attenuates the postprandial suppression of BRMs.
+
+ INTRODUCTION: Acute exercise transiently increases BRMs including osteocalcin (tOC) and the undercarboxylated form of osteocalcin (ucOC), a hormone that is implicated in glucose regulation. The effects of acute exercise and exercise-intensity on postprandial levels of tOC and ucOC are unknown.
+
+ METHODS: Twenty-seven adults that were overweight or obese (age 30 +/- 1 years; BMI 30 +/- 1 kg.m-2; mean +/- SEM) were randomly allocated to perform a single session of low-volume high-intensity interval exercise (LV-HIIE; nine females, five males) or continuous moderate-intensity exercise (CMIE; eightfemales, five males) 1 h after consumption of a standard breakfast. Serum tOC, ucOC, and ucOC/tOC were measured at baseline, 1 h, and 3 h after breakfast consumption on a rest day (no exercise) and the exercise day (exercise 1 h after breakfast).
+
+ RESULTS: Compared to baseline, serum tOC and ucOC were suppressed 3 h after breakfast on the rest day (- 10 +/- 1% and - 6 +/- 2%, respectively; p < 0.05), whereas ucOC/tOC was elevated (2.5 +/- 1%; p = 0.08). Compared to the rest day, CMIE attenuated the postprandial-induced suppression of tOC (rest day - 10 +/- 2% versus CMIE - 5 +/- 2%, p < 0.05) and ucOC (rest day - 6 +/- 4% versus CMIE 11 +/- 2%, p < 0.05), and increased postprandial ucOC/tOC (rest day 3 +/- 2% versus CMIE 15 +/- 1%, p < 0.05). In contrast, LV-HIIE did not alter postprandial tOC, ucOC, or ucOC/tOC (all p > 0.1).
+
+ CONCLUSIONS: Acute CMIE, but not LV-HIIE, attenuates the postprandial-induced suppression of tOC and ucOC. CMIE may be an effective tool to control the circulating levels of BRMs following meal consumption in overweight/obese adults.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 104982-03-8 (Osteocalcin).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00198-018-4719-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Parker&issn=0937-941X&title=Osteoporosis+International&atitle=Acute+continuous+moderate-intensity+exercise%2C+but+not+low-volume+high-intensity+interval+exercise%2C+attenuates+postprandial+suppression+of+circulating+osteocalcin+in+young+overweight+and+obese+adults.&volume=30&issue=2&spage=403&epage=410&date=2019&doi=10.1007%2Fs00198-018-4719-y&pmid=30306222&sid=OVID:medline
+
+<1886>
+Unique Identifier
+ 30303711
+Title
+ Aerobic interval exercise improves renal functionality and affects mineral metabolism in obese Zucker rats.
+Source
+ American Journal of Physiology - Renal Physiology. 316(1):F90-F100, 2019 01 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Martinez R; Kapravelou G; Lopez-Chaves C; Caceres E; Coll-Risco I; Sanchez-Gonzalez C; Llopis J; Arrebola F; Galisteo M; Aranda P; Lopez-Jurado M; Porres JM
+Author NameID
+ Porres, Jesus M; ORCID: https://orcid.org/0000-0001-5657-0764
+Authors Full Name
+ Martinez, Rosario; Kapravelou, Garyfallia; Lopez-Chaves, Carlos; Caceres, Elena; Coll-Risco, Irene; Sanchez-Gonzalez, Cristina; Llopis, Juan; Arrebola, Francisco; Galisteo, Milagros; Aranda, Pilar; Lopez-Jurado, Maria; Porres, Jesus M.
+Institution
+ Martinez, Rosario. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Kapravelou, Garyfallia. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Lopez-Chaves, Carlos. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Caceres, Elena. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Coll-Risco, Irene. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Sanchez-Gonzalez, Cristina. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Llopis, Juan. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Arrebola, Francisco. Department of Histology, Institute of Neurosciences, Centre for Biomedical Research, Universidad de Granada, Granada, Spain.
+ Galisteo, Milagros. Department of Pharmacology, School of Pharmacy, Universidad de Granada, Campus Universitario de Cartuja, Granada, Spain.
+ Aranda, Pilar. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Lopez-Jurado, Maria. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+ Porres, Jesus M. Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Centre for Research in Sport and Health, Universidad de Granada, Granada, Spain.
+MeSH Subject Headings
+ Albuminuria/et [Etiology]
+ Albuminuria/me [Metabolism]
+ Albuminuria/pp [Physiopathology]
+ Albuminuria/pc [Prevention & Control]
+ Animals
+ Biomarkers/bl [Blood]
+ Biomarkers/ur [Urine]
+ Chronic Kidney Disease-Mineral and Bone Disorder/et [Etiology]
+ Chronic Kidney Disease-Mineral and Bone Disorder/me [Metabolism]
+ Chronic Kidney Disease-Mineral and Bone Disorder/pp [Physiopathology]
+ *Chronic Kidney Disease-Mineral and Bone Disorder/pc [Prevention & Control]
+ Disease Models, Animal
+ *Femur/me [Metabolism]
+ Glomerulonephritis/et [Etiology]
+ Glomerulonephritis/me [Metabolism]
+ Glomerulonephritis/pp [Physiopathology]
+ *Glomerulonephritis/pc [Prevention & Control]
+ *High-Intensity Interval Training
+ Hypertrophy
+ Kidney/pa [Pathology]
+ *Kidney/pp [Physiopathology]
+ Male
+ *Minerals/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Rats, Zucker
+ Recovery of Function
+ Time Factors
+Keyword Heading
+ Zucker rat
+ aerobic interval training
+ diabetic nephropathy
+ glomerulosclerosis
+ mineral metabolism
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity, metabolic syndrome, and renal injury are considered risk factors for type 2 diabetes, as well as kidney disease. Functional and structural changes in the kidney as consequence of obesity and metabolic syndrome may lead to impaired mineral metabolism in what is known as chronic kidney disease-mineral and bone disorder. Lifestyle interventions such as physical activity are good strategies to manage these pathologies and therefore, prevent the loss of kidney functionality and related complications in mineral metabolism. In this study, we have used 40 male Zucker rats that were randomly allocated into four different experimental groups, two of them (an obese and a lean one) performed an aerobic interval training protocol, and the other two groups were sedentary. At the end of the experimental period (8 wk), urine, plasma, and femur were collected for biochemical and mineral composition analysis, whereas the kidney was processed for histological studies. The obese rats exhibited albuminuria, glomerulosclerosis, and hypertrophy in glomeruli and renal tubule in some areas, together with alterations in mineral content of plasma but not of femur. The training protocol prevented the generation of albuminuria and glomerulosclerosis, showing a significant action on plasma and bone mineral levels. Therefore, the specific training protocol used in this study was able to prevent the development of diabetic nephropathy and affected the metabolism of certain minerals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Minerals).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1152%2fajprenal.00356.2018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Martinez&issn=1522-1466&title=American+Journal+of+Physiology+-+Renal+Physiology&atitle=Aerobic+interval+exercise+improves+renal+functionality+and+affects+mineral+metabolism+in+obese+Zucker+rats.&volume=316&issue=1&spage=F90&epage=F100&date=2019&doi=10.1152%2Fajprenal.00356.2018&pmid=30303711&sid=OVID:medline
+
+<1887>
+Unique Identifier
+ 30289975
+Title
+ The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk.
+Source
+ International Journal of Cancer. 144(3):641-650, 2019 02 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ MacKintosh ML; Derbyshire AE; McVey RJ; Bolton J; Nickkho-Amiry M; Higgins CL; Kamieniorz M; Pemberton PW; Kirmani BH; Ahmed B; Syed AA; Ammori BJ; Renehan AG; Kitchener HC; Crosbie EJ
+Author NameID
+ Crosbie, Emma J; ORCID: https://orcid.org/0000-0003-0284-8630
+Authors Full Name
+ MacKintosh, Michelle L; Derbyshire, Abigail E; McVey, Rhona J; Bolton, James; Nickkho-Amiry, Mahshid; Higgins, Catherine L; Kamieniorz, Martyna; Pemberton, Philip W; Kirmani, Bilal H; Ahmed, Babur; Syed, Akheel A; Ammori, Basil J; Renehan, Andrew G; Kitchener, Henry C; Crosbie, Emma J.
+Institution
+ MacKintosh, Michelle L. Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ Derbyshire, Abigail E. Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ McVey, Rhona J. Department of Histopathology, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ Bolton, James. Department of Histopathology, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ Nickkho-Amiry, Mahshid. Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ Higgins, Catherine L. Department of Histopathology, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ Kamieniorz, Martyna. Department of Histopathology, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ Pemberton, Philip W. Department of Clinical Biochemistry, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ Kirmani, Bilal H. Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom.
+ Ahmed, Babur. Department of Obesity Medicine, Diabetes & Endocrinology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom.
+ Syed, Akheel A. Department of Obesity Medicine, Diabetes & Endocrinology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom.
+ Syed, Akheel A. Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom.
+ Ammori, Basil J. Department of Obesity Medicine, Diabetes & Endocrinology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom.
+ Ammori, Basil J. Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom.
+ Renehan, Andrew G. Obesity and Cancer Research Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Cancer Research Centre, NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester, United Kingdom.
+ Kitchener, Henry C. Gynaecological Oncology Research Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
+ Crosbie, Emma J. Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
+ Crosbie, Emma J. Gynaecological Oncology Research Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Bariatric Surgery/mt [Methods]
+ Biomarkers/bl [Blood]
+ Cohort Studies
+ Endometrial Neoplasms/bl [Blood]
+ Endometrial Neoplasms/pa [Pathology]
+ *Endometrial Neoplasms/pc [Prevention & Control]
+ Endometrium/pa [Pathology]
+ Female
+ Humans
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ *Obesity/su [Surgery]
+ Prospective Studies
+ Young Adult
+Keyword Heading
+ atypical endometrial hyperplasia
+ bariatric surgery
+ endometrial cancer
+ obesity
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is the strongest risk factor for endometrial cancer (EC). To inform targeted screening and prevention strategies, we assessed the impact of obesity and subsequent bariatric surgery-induced weight loss on endometrial morphology and molecular pathways implicated in endometrial carcinogenesis. Blood and endometrial tissue were obtained from women with class III-IV obesity (body mass index >=40 and >=50 kg/m2 , respectively) immediately prior to gastric bypass or sleeve gastrectomy, and at two and 12 months' follow up. The endometrium underwent pathological examination and immunohistochemistry was used to quantify proliferation (Ki-67), oncogenic signaling (PTEN, pAKT, pERK) and hormone receptor (ER, PR) expression status. Circulating biomarkers of insulin resistance, reproductive function and inflammation were also measured at each time point. Seventy-two women underwent bariatric surgery. At 12 months, the mean change in total and excess body weight was -32.7 and -62.8%, respectively. Baseline endometrial biopsies revealed neoplastic change in 10 women (14%): four had EC, six had atypical hyperplasia (AH). After bariatric surgery, most cases of AH resolved (5/6) without intervention (3/6) or with intrauterine progestin (2/6). Biomarkers of endometrial proliferation (Ki-67), oncogenic signaling (pAKT) and hormone receptor status (ER, PR) were significantly reduced, with restoration of glandular PTEN expression, at 2 and 12 months. There were reductions in circulating biomarkers of insulin resistance (HbA1c, HOMA-IR) and inflammation (hsCRP, IL-6), and increases in reproductive biomarkers (LH, FSH, SHBG). We found an unexpectedly high prevalence of occult neoplastic changes in the endometrium of women undergoing bariatric surgery. Their spontaneous reversal and accompanying down-regulation of PI3K-AKT-mTOR signaling with weight loss may have implications for screening, prevention and treatment of this disease. Copyright © 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fijc.31913
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=MacKintosh&issn=0020-7136&title=International+Journal+of+Cancer&atitle=The+impact+of+obesity+and+bariatric+surgery+on+circulating+and+tissue+biomarkers+of+endometrial+cancer+risk.&volume=144&issue=3&spage=641&epage=650&date=2019&doi=10.1002%2Fijc.31913&pmid=30289975&sid=OVID:medline
+
+<1888>
+Unique Identifier
+ 30287050
+Title
+ Serum FABP4 concentrations decrease after Roux-en-Y gastric bypass but not after intensive medical management.
+Source
+ Surgery. 165(3):571-578, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jahansouz C; Xu H; Kizy S; Thomas AJ; Josephrajan A; Hertzel AV; Foncea R; Connett JC; Billington CJ; Jensen M; Korner J; Bernlohr DA; Ikramuddin S
+Authors Full Name
+ Jahansouz, Cyrus; Xu, Hongliang; Kizy, Scott; Thomas, Avis J; Josephrajan, Ajeetha; Hertzel, Ann V; Foncea, Rocio; Connett, John C; Billington, Charles J; Jensen, Michael; Korner, Judith; Bernlohr, David A; Ikramuddin, Sayeed.
+Institution
+ Jahansouz, Cyrus. Department of Surgery, University of Minnesota, Minneapolis, MN.
+ Xu, Hongliang. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN.
+ Kizy, Scott. Department of Surgery, University of Minnesota, Minneapolis, MN.
+ Thomas, Avis J. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN.
+ Josephrajan, Ajeetha. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN.
+ Hertzel, Ann V. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN.
+ Foncea, Rocio. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN.
+ Connett, John C. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN.
+ Billington, Charles J. Department of Medicine, Division of Endocrinology & Diabetes, University of Minnesota, Minneapolis, MN.
+ Jensen, Michael. Department of Medicine, Division of Endocrinology & Diabetes, Mayo Clinic, Rochester, MN.
+ Korner, Judith. Department of Medicine, Division of Endocrinology, Columbia University Medical Center, New York, NY.
+ Bernlohr, David A. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN.
+ Ikramuddin, Sayeed. Department of Surgery, University of Minnesota, Minneapolis, MN. Electronic address: Ikram001@umn.edu.
+MeSH Subject Headings
+ Adjuvants, Immunologic/tu [Therapeutic Use]
+ Biomarkers/bl [Blood]
+ *Colforsin/tu [Therapeutic Use]
+ *Critical Care/mt [Methods]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/th [Therapy]
+ *Fatty Acid-Binding Proteins/bl [Blood]
+ Female
+ Follow-Up Studies
+ *Gastric Bypass/mt [Methods]
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/th [Therapy]
+ *Risk Reduction Behavior
+ Treatment Outcome
+Abstract
+ BACKGROUND: Serum concentrations of fatty acid binding protein 4, an adipose tissue fatty acid chaperone, have been correlated with insulin resistance and cardiovascular risk factors. The objective of this study were to assess relationships among Roux-en-Y gastric bypass, intensive lifestyle modification and medical management protocol, fatty acid binding protein 4, and metabolic parameters in obese patients with severe type 2 diabetes mellitus; and to evaluate the relative contribution of abdominal subcutaneous adipose and visceral adipose to the secretion of fatty acid binding protein 4.
+
+ METHODS: Participants were randomly assigned to intensive lifestyle modification and medical management protocol (n=29) or to intensive lifestyle modification and medical management protocol augmented with Roux-en-Y gastric bypass (n=34). Relationships among fatty acid binding protein 4 and demographic characteristics, metabolic parameters, and 12-month changes in these values were examined. Visceral and subcutaneous adipose tissue explants from obese nondiabetic patients (n=5) were obtained and treated with forskolin to evaluate relative secretion of fatty acid binding protein 4 in the different adipose tissue depots.
+
+ RESULTS: The intensive lifestyle modification and medical management protocol and Roux-en-Y gastric bypass cohorts had similar fasting serum fatty acid binding protein 4 concentrations at baseline. At 1 year, mean serum fatty acid binding protein 4 decreased by 42% in Roux-en-Y gastric bypass participants (P=.002) but did not change significantly in the intensive lifestyle modification and medical management protocol cohort. Percentage of weight change was not a significant predictor of 12-month fatty acid binding protein 4 within treatment arm or in multivariate models adjusted for treatment arm. In adipose tissue explants, fatty acid binding protein 4 was secreted similarly between visceral and subcutaneous adipose tissue.
+
+ CONCLUSION: After Roux-en-Y gastric bypass, fatty acid binding protein 4 is reduced 12 months after surgery but not after intensive lifestyle modification and medical management protocol in patients with type 2 diabetes mellitus. Fatty acid binding protein 4 was secreted similarly between subcutaneous and visceral adipose tissue explants. Copyright © 2018 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adjuvants, Immunologic). 0 (Biomarkers). 0 (FABP4 protein, human). 0 (Fatty Acid-Binding Proteins). 1F7A44V6OU (Colforsin).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.surg.2018.08.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jahansouz&issn=0039-6060&title=Surgery&atitle=Serum+FABP4+concentrations+decrease+after+Roux-en-Y+gastric+bypass+but+not+after+intensive+medical+management.&volume=165&issue=3&spage=571&epage=578&date=2019&doi=10.1016%2Fj.surg.2018.08.007&pmid=30287050&sid=OVID:medline
+
+<1889>
+Unique Identifier
+ 30280616
+Title
+ Metabolic syndrome is associated to high-sensitivity cardiac troponin T elevation.
+Source
+ Biomarkers. 24(2):153-158, 2019 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Milwidsky A; Fisher E; Brzezinski RY; Ehrenwald M; Shefer G; Stern N; Shapira I; Zeltser D; Rosenbaum Z; Greidinger D; Berliner S; Shenhar-Tsarfaty S; Rogowski O
+Author NameID
+ Milwidsky, Assi; ORCID: http://orcid.org/0000-0002-3319-0336
+Authors Full Name
+ Milwidsky, Assi; Fisher, Eyal; Brzezinski, Rafael Y; Ehrenwald, Michal; Shefer, Gabi; Stern, Naftali; Shapira, Itzhak; Zeltser, David; Rosenbaum, Zach; Greidinger, Dahlia; Berliner, Shlomo; Shenhar-Tsarfaty, Shani; Rogowski, Ori.
+Institution
+ Milwidsky, Assi. a Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Cardiology, Tel Aviv University, Tel Aviv, Israel.
+ Fisher, Eyal. b Department of Statistics, School of Mathematical Science, Tel Aviv University, Tel Aviv, Israel.
+ Brzezinski, Rafael Y. c Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Internal Medicine "C", "D" and "E", Tel Aviv University, Tel Aviv, Israel.
+ Ehrenwald, Michal. c Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Internal Medicine "C", "D" and "E", Tel Aviv University, Tel Aviv, Israel.
+ Shefer, Gabi. d Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
+ Stern, Naftali. d Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
+ Shapira, Itzhak. e The Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
+ Zeltser, David. c Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Internal Medicine "C", "D" and "E", Tel Aviv University, Tel Aviv, Israel.
+ Rosenbaum, Zach. a Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Cardiology, Tel Aviv University, Tel Aviv, Israel.
+ Greidinger, Dahlia. a Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Cardiology, Tel Aviv University, Tel Aviv, Israel.
+ Berliner, Shlomo. c Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Internal Medicine "C", "D" and "E", Tel Aviv University, Tel Aviv, Israel.
+ Shenhar-Tsarfaty, Shani. c Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Internal Medicine "C", "D" and "E", Tel Aviv University, Tel Aviv, Israel.
+ Rogowski, Ori. c Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Department of Internal Medicine "C", "D" and "E", Tel Aviv University, Tel Aviv, Israel.
+MeSH Subject Headings
+ Aged
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/pp [Physiopathology]
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Heart/pp [Physiopathology]
+ Humans
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Risk Factors
+ *Troponin T/bl [Blood]
+Keyword Heading
+ Troponin-T
+ cardiovascular risk
+ diabetes
+ metabolic syndrome
+ obesity
+ sub-clinical myocardial injury
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Metabolic syndrome (MetS) and high-sensitivity cardiac troponin T (hs-TnT) are associated with higher risk for cardiovascular diseases (CVD). Our aim was to assess the relation between hs-TnT elevation and MetS in a general population sample.
+
+ MATERIALS AND METHODS: Individuals participating in an annual health survey program between 2010 and 2016 were included in the study. Blood samples including hs-TnT levels were collected. The study population was divided into three groups based on hs-TnT levels - undetectable (<5 ng/L), intermediate (5-14 ng/L) and elevated (>14 ng/L).
+
+ RESULTS: A total of 5994 subjects were included in the study, the mean age was 48.5 and 4336 (72%) were males. Compared with subjects with undetectable hs-TnT the prevalence of MetS was higher in those with detectable and elevated levels - 392 (10%) vs. 270 (15%) and 51 (33%), respectively (p < 0.001). In a multivariate model adjusted for age, gender and multiple co-morbidities, the number of MetS components and presence of MetS were significantly associated with an increased risk for detectable hs-TnT levels (OR = 1.02 {for each component}; 95% CI [1.00-1.05], p = 0.04) and (OR = 1.13; 95% CI [1.07-1.2], p < 0.001) respectively. Only the waist, glucose and hypertension components of the MetS were significantly associated with elevated troponin.
+
+ CONCLUSIONS: The MetS and its distinct components have a cumulative impact on hs-TnT levels in apparently healthy subjects.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Troponin T).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f1354750X.2018.1528630
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Milwidsky&issn=1354-750X&title=Biomarkers&atitle=Metabolic+syndrome+is+associated+to+high-sensitivity+cardiac+troponin+T+elevation.&volume=24&issue=2&spage=153&epage=158&date=2019&doi=10.1080%2F1354750X.2018.1528630&pmid=30280616&sid=OVID:medline
+
+<1890>
+Unique Identifier
+ 30277921
+Title
+ Effect of high-intensity interval training on body composition and inflammatory markers in obese postmenopausal women: a randomized controlled trial.
+Source
+ Menopause. 26(3):256-264, 2019 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nunes PRP; Martins FM; Souza AP; Carneiro MAS; Orsatti CL; Michelin MA; Murta EFC; de Oliveira EP; Orsatti FL
+Authors Full Name
+ Nunes, Paulo R P; Martins, Fernanda M; Souza, Aleteia P; Carneiro, Marcelo A S; Orsatti, Claudio L; Michelin, Marcia A; Murta, Eddie F C; de Oliveira, Erick P; Orsatti, Fabio L.
+Institution
+ Nunes, Paulo R P. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Martins, Fernanda M. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Souza, Aleteia P. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Carneiro, Marcelo A S. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Orsatti, Claudio L. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Michelin, Marcia A. Oncology Research Institute (IPON), Gynecology and Obstetrics program, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Murta, Eddie F C. Oncology Research Institute (IPON), Gynecology and Obstetrics program, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ de Oliveira, Erick P. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ de Oliveira, Erick P. School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil.
+ Orsatti, Fabio L. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Orsatti, Fabio L. Department of Sport Sciences, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Composition/ph [Physiology]
+ Female
+ *High-Intensity Interval Training/mt [Methods]
+ Humans
+ Interleukin-6/bl [Blood]
+ *Intra-Abdominal Fat/pa [Pathology]
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Postmenopause/ph [Physiology]
+ Receptors, Interleukin-1/bl [Blood]
+Abstract
+ OBJECTIVES: This study tested whether high-intensity interval training is a time-efficient strategy for improving visceral adiposity tissue and inflammatory markers in obese postmenopausal women when compared with combined training. Moreover, we tested whether change in visceral adiposity tissue is associated with alterations in these inflammatory markers.
+
+ METHODS: Postmenopausal women were randomized in two groups: combined training (n = 13) and high-intensity interval training (n = 13). The combined training group performed 60 minutes of walking at 70% of maximum heart rate and resistance exercises at 70% of one repetition maximum. The high-intensity interval training group performed 28 minutes of high-intensity exercises (> 80% of maximum heart rate). Both groups trained three times a week for 12 weeks. Body composition and inflammatory markers were analyzed with dual-energy x-ray absorptiometry scanning and enzyme-linked immunosorbent assay, respectively.
+
+ RESULTS: All groups reduced body fat percentage (P = 0.026), visceral adiposity tissue (P = 0.027), leptin (P = 0.043), and increased interleukin (IL)-1 receptor antagonist (P < 0.01). The high-intensity interval training group reduced visceral adiposity tissue (P = 0.021) in a greater magnitude and increased interleukin-6 (P = 0.037) level when compared with the combined training group. Moreover, the visceral adiposity tissue changes explained the changes in IL-6 (56%; P = 0.002) only in the high-intensity interval training group.
+
+ CONCLUSIONS: These results suggest that high-intensity interval training is a time-efficient strategy for improving visceral adiposity tissue and inflammatory markers in obese postmenopausal women. Moreover, we observed that serum cytokine changes, at least in part, depend on visceral adiposity tissue alterations.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Interleukin-6). 0 (Receptors, Interleukin-1).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fGME.0000000000001207
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nunes&issn=1072-3714&title=Menopause&atitle=Effect+of+high-intensity+interval+training+on+body+composition+and+inflammatory+markers+in+obese+postmenopausal+women%3A+a+randomized+controlled+trial.&volume=26&issue=3&spage=256&epage=264&date=2019&doi=10.1097%2FGME.0000000000001207&pmid=30277921&sid=OVID:medline
+
+<1891>
+Unique Identifier
+ 30273797
+Title
+ Amygdalar activity predicts future incident diabetes independently of adiposity.
+Source
+ Psychoneuroendocrinology. 100:32-40, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Osborne MT; Ishai A; Hammad B; Tung B; Wang Y; Baruch A; Fayad ZA; Giles JT; Lo J; Shin LM; Grinspoon SK; Koenen KC; Pitman RK; Tawakol A
+Authors Full Name
+ Osborne, Michael T; Ishai, Amorina; Hammad, Basma; Tung, Brian; Wang, Ying; Baruch, Amos; Fayad, Zahi A; Giles, Jon T; Lo, Janet; Shin, Lisa M; Grinspoon, Steven K; Koenen, Karestan C; Pitman, Roger K; Tawakol, Ahmed.
+Institution
+ Osborne, Michael T. Cardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA; Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, MA, 02114, USA. Electronic address: mosborne@mgh.harvard.edu.
+ Ishai, Amorina. Cardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA. Electronic address: amorinaishai@gmail.com.
+ Hammad, Basma. Cardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA. Electronic address: basmaabdelkader@gmail.com.
+ Tung, Brian. Cardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA. Electronic address: btung@nymc.edu.
+ Wang, Ying. Cardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA. Electronic address: ywang88@mgh.harvard.edu.
+ Baruch, Amos. OMNI Biomarker Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. Electronic address: baruch.amos@gene.com.
+ Fayad, Zahi A. Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA. Electronic address: zahi.fayad@mssm.edu.
+ Giles, Jon T. Department of Rheumatology, Columbia University, 630 W. 168th St, New York, NY, 10032, USA. Electronic address: jtg2122@cumc.columbia.edu.
+ Lo, Janet. Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA. Electronic address: jlo@mgh.harvard.edu.
+ Shin, Lisa M. Department of Psychology, Tufts University, 490 Boston Ave, Medford, MA, 02155, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA, 02129, USA. Electronic address: Lisa.Shin@tufts.edu.
+ Grinspoon, Steven K. Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA; Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA. Electronic address: sgrinspoon@mgh.harvard.edu.
+ Koenen, Karestan C. Harvard University T.H. Chan School of Public Health, 677 Huntington Ave, Kresge Building, Boston, MA, 02115, USA. Electronic address: kkoenen@hsph.harvard.edu.
+ Pitman, Roger K. Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA, 02129, USA. Electronic address: roger.pitman@mgh.harvard.edu.
+ Tawakol, Ahmed. Cardiac MR-PET-CT Program, Massachusetts General Hospital, 165 Cambridge St, Suite 400, Boston, MA, 02114, USA; Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, MA, 02114, USA. Electronic address: atawakol@mgh.harvard.edu.
+MeSH Subject Headings
+ *Adiposity/ph [Physiology]
+ Adult
+ Aged
+ Amygdala/dg [Diagnostic Imaging]
+ *Amygdala/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Fluorodeoxyglucose F18/pk [Pharmacokinetics]
+ Humans
+ Incidence
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Positron Emission Tomography Computed Tomography
+ Predictive Value of Tests
+ Prognosis
+ Retrospective Studies
+Keyword Heading
+ Amygdala
+ Diabetes mellitus
+ Positron emission tomography/computed tomography
+ Visceral adiposity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ While it is established that psychosocial stress increases the risk of developing diabetes mellitus (DM), two key knowledge gaps remain: 1) the neurobiological mechanisms that are involved in mediating that risk, and 2) the role, if any, that adiposity plays in that mechanism. We tested the hypotheses that: 1) metabolic activity in the amygdala (AmygA), a key center involved in the neurobiological response to stress, associates with subsequent DM risk, and 2) this association is independent of adiposity. AmygA and adipose tissue volumes were measured, and serial blood assessments for DM were obtained in 232 subjects who underwent combined 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) imaging. Higher baseline AmygA predicted subsequent, new-onset DM, independently of adiposity and other DM risk factors. Furthermore, higher adiposity only increased DM risk in the presence of higher AmygA. In a separate cross-sectional cohort, higher AmygA associated with higher insulin resistance. Accordingly, the current study shows, for the first time, that activity in a stress-responsive neural region predicts the onset of DM. Further, we observed that this neurobiological activity acts independently of, but also synergistically with adiposity to increase DM risk. These findings suggest novel therapeutic targets to help manage and possibly prevent DM. Copyright © 2018 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0Z5B2CJX4D (Fluorodeoxyglucose F18).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.psyneuen.2018.09.024
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Osborne&issn=0306-4530&title=Psychoneuroendocrinology&atitle=Amygdalar+activity+predicts+future+incident+diabetes+independently+of+adiposity.&volume=100&issue=&spage=32&epage=40&date=2019&doi=10.1016%2Fj.psyneuen.2018.09.024&pmid=30273797&sid=OVID:medline
+
+<1892>
+Unique Identifier
+ 30268840
+Title
+ Serum levels of osteopontin predict diabetes remission after bariatric surgery.
+Source
+ Diabetes & Metabolism. 45(4):356-362, 2019 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Carbone F; Adami G; Liberale L; Bonaventura A; Bertolotto M; Andraghetti G; Scopinaro N; Camerini GB; Papadia FS; Cordera R; Dallegri F; Montecucco F
+Authors Full Name
+ Carbone, F; Adami, G; Liberale, L; Bonaventura, A; Bertolotto, M; Andraghetti, G; Scopinaro, N; Camerini, G B; Papadia, F S; Cordera, R; Dallegri, F; Montecucco, F.
+Institution
+ Carbone, F. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy. Electronic address: federico.carbone@edu.unige.it.
+ Adami, G. Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
+ Liberale, L. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; Centre for Molecular Cardiology, University of Zurich, 12 Wagistrasse, 8952 Schlieren, Switzerland.
+ Bonaventura, A. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
+ Bertolotto, M. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
+ Andraghetti, G. Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
+ Scopinaro, N. Department of Surgery, University of Genoa, 10 Largo Benzi, 16132 Genoa, Italy.
+ Camerini, G B. Department of Surgery, University of Genoa, 10 Largo Benzi, 16132 Genoa, Italy.
+ Papadia, F S. Department of Surgery, University of Genoa, 10 Largo Benzi, 16132 Genoa, Italy.
+ Cordera, R. Diabetology Unit, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
+ Dallegri, F. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; First Clinic of Internal Medicine, Ospedale Policlinico San Martino, 10 Largo Benzi, 16132, Genoa, Italy.
+ Montecucco, F. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; First Clinic of Internal Medicine, Ospedale Policlinico San Martino, 10 Largo Benzi, 16132, Genoa, Italy; Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 9 viale Benedetto XV, 16132 Genoa, Italy.
+MeSH Subject Headings
+ Adult
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/su [Surgery]
+ Humans
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/su [Surgery]
+ *Osteopontin/bl [Blood]
+ Pilot Projects
+ Prognosis
+ Remission Induction
+ Retrospective Studies
+ Treatment Outcome
+Keyword Heading
+ Bariatric surgery
+ HOMA2
+ Obesity
+ Osteopontin
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Bariatric surgery has been shown to effectively improve glycaemic control in morbidly obese subjects. However, the molecular bases of this association are still elusive and may act independently of weight loss. Here, our retrospective study has investigated the inflammatory molecule osteopontin (OPN) as a potential predictor of type 2 diabetes mellitus (T2DM) remission.
+
+ METHODS: Baseline serum levels of OPN were analyzed in 41 T2DM patients who underwent bariatric surgery. Anthropometric measures and biochemical variables, including insulin sensitivity indices (HOMA2), were assessed at baseline and at 1 and 3 years after surgery.
+
+ RESULTS: At baseline, patients who experienced T2DM remission had increased waist circumference, body weight and BMI, and higher serum OPN, compared with non-remitters. Patients with and without T2DM remission improved their lipid and glucose profiles, although insulin resistance indices were only improved in the T2DM remission group. In the overall cohort of both T2DM remission and non-remission patients, baseline circulating levels of OPN significantly correlated with reductions of body weight and BMI over time, and insulin sensitivity improved as well. However, only the HOMA2-%S remained independently associated with serum OPN on multivariate linear regression analysis (B: 0.227, 95% CI: 0.067-0.387, beta = 0.831; P = 0.010). Baseline values of OPN predicted 3-year T2DM remission independently of body weight loss, lower BMI and duration of diabetes (OR: 1.046, 95% CI: 1.004-1.090; P = 0.033).
+
+ CONCLUSION: Although larger studies are still needed to confirm our preliminary results, pre-operative OPN serum levels might be useful for predicting 3-year T2DM remission independently of weight loss in patients undergoing bariatric surgery. Copyright © 2018 Elsevier Masson SAS. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 106441-73-0 (Osteopontin).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.diabet.2018.09.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Carbone&issn=1262-3636&title=Diabetes+%26+Metabolism&atitle=Serum+levels+of+osteopontin+predict+diabetes+remission+after+bariatric+surgery.&volume=45&issue=4&spage=356&epage=362&date=2019&doi=10.1016%2Fj.diabet.2018.09.007&pmid=30268840&sid=OVID:medline
+
+<1893>
+Unique Identifier
+ 30254363
+Title
+ Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort.
+Source
+ International Journal of Obesity. 43(5):1070-1081, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jaaskelainen T; Heinonen S; Hamalainen E; Pulkki K; Romppanen J; Laivuori H
+Author NameID
+ Jaaskelainen, Tiina; ORCID: http://orcid.org/0000-0002-1202-0936
+Corporate Author
+ FINNPEC
+Authors Full Name
+ Jaaskelainen, Tiina; Heinonen, Seppo; Hamalainen, Esa; Pulkki, Kari; Romppanen, Jarkko; Laivuori, Hannele.
+Institution
+ Jaaskelainen, Tiina. Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. tiina.j.jaaskelainen@helsinki.fi.
+ Heinonen, Seppo. Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Hamalainen, Esa. Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland.
+ Hamalainen, Esa. VITA Healthcare Services Ltd., Helsinki, Finland.
+ Pulkki, Kari. Eastern Finland Laboratory Centre, Kuopio, Finland.
+ Pulkki, Kari. Laboratory Division, Turku University Hospital, Turku, Finland.
+ Romppanen, Jarkko. Eastern Finland Laboratory Centre, Kuopio, Finland.
+ Laivuori, Hannele. Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
+ Laivuori, Hannele. Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
+ Laivuori, Hannele. Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
+ Laivuori, Hannele. Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Cohort Studies
+ Endoglin/me [Metabolism]
+ Female
+ Finland/ep [Epidemiology]
+ Humans
+ Inflammation/et [Etiology]
+ *Inflammation/pp [Physiopathology]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Placenta Growth Factor/me [Metabolism]
+ Pre-Eclampsia/et [Etiology]
+ *Pre-Eclampsia/ge [Genetics]
+ Pre-Eclampsia/me [Metabolism]
+ *Pre-Eclampsia/pp [Physiopathology]
+ Predictive Value of Tests
+ Pregnancy
+ Pregnancy Complications/me [Metabolism]
+ *Pregnancy Complications/pp [Physiopathology]
+ Pregnancy Trimester, First
+ Pregnancy Trimester, Third
+ Receptors, Immunologic/me [Metabolism]
+Abstract
+ BACKGROUND: While several studies have demonstrated that obesity increases the risk of pre-eclampsia (PE), the mechanisms have yet to be elucidated. We assessed the association between maternal/paternal obesity and PE and hypothesized that maternal body mass index (BMI) would be associated with an adverse inflammatory and angiogenic profile. High-sensitivity C-reactive protein (hs-CRP) and following serum angiogenic markers were determined: soluble endoglin (sEng), soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF).
+
+ METHODS: Data on BMI were available from 1450 pregnant women with PE and 1065 without PE. Serum concentrations of hs-CRP and angiogenic markers were available from a subset at first and third trimesters.
+
+ RESULTS: Prepregnancy BMI was higher in the PE group than in controls (mean +/- SD) 25.3 +/- 5.2 vs. 24.1 +/- 4,4, p < 0.001, adjusted for parity, mother's age, and smoking status before pregnancy. Increased hs-CRP concentrations were observed in both PE and non-PE women similarly according to BMI category. In women with PE, a higher BMI was associated with lower sFlt-1 and sEng concentrations throughout the pregnancy (p = 0.004, p = 0.008, respectively). There were no differences in PlGF in PE women according to BMI.
+
+ CONCLUSIONS: We confirmed increased pre-pregnancy BMI in women with PE. Enhanced inflammatory state was confirmed in all women with overweight/obesity. Partly paradoxically we observed that PE women with obesity had less disturbed levels of angiogenic markers than normal weight women with PE. This should be taken into account when angiogenic markers are used in PE prediction.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CRP protein, human). 0 (Endoglin). 0 (PGF protein, human). 0 (Receptors, Immunologic). 144589-93-5 (Placenta Growth Factor).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0217-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jaaskelainen&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Impact+of+obesity+on+angiogenic+and+inflammatory+markers+in+the+Finnish+Genetics+of+Pre-eclampsia+Consortium+%28FINNPEC%29+cohort.&volume=43&issue=5&spage=1070&epage=1081&date=2019&doi=10.1038%2Fs41366-018-0217-8&pmid=30254363&sid=OVID:medline
+
+<1894>
+Unique Identifier
+ 30251622
+Title
+ Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial.
+Source
+ British Journal of Psychiatry. 214(2):63-73, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Holt RIG; Gossage-Worrall R; Hind D; Bradburn MJ; McCrone P; Morris T; Edwardson C; Barnard K; Carey ME; Davies MJ; Dickens CM; Doherty Y; Etherington A; French P; Gaughran F; Greenwood KE; Kalidindi S; Khunti K; Laugharne R; Pendlebury J; Rathod S; Saxon D; Shiers D; Siddiqi N; Swaby EA; Waller G; Wright S
+Author NameID
+ Holt, Richard I G; ORCID: https://orcid.org/0000-0001-8911-6744
+Authors Full Name
+ Holt, Richard I G; Gossage-Worrall, Rebecca; Hind, Daniel; Bradburn, Michael J; McCrone, Paul; Morris, Tiyi; Edwardson, Charlotte; Barnard, Katharine; Carey, Marian E; Davies, Melanie J; Dickens, Chris M; Doherty, Yvonne; Etherington, Angela; French, Paul; Gaughran, Fiona; Greenwood, Kathryn E; Kalidindi, Sridevi; Khunti, Kamlesh; Laugharne, Richard; Pendlebury, John; Rathod, Shanaya; Saxon, David; Shiers, David; Siddiqi, Najma; Swaby, Elizabeth A; Waller, Glenn; Wright, Stephen.
+Institution
+ Holt, Richard I G. Professor in Diabetes and Endocrinology,Human Development and Health Academic Unit,Faculty of Medicine,University of Southampton andHonorary Consultant Physician, Division B,University Hospital Southampton NHS Foundation Trust,UK.
+ Gossage-Worrall, Rebecca. Trial Manager (Research Associate),Clinical Trials Research Unit,School of Health and Related Research,University of Sheffield,UK.
+ Hind, Daniel. Reader in Complex Interventions and Assistant Director,Clinical Trials Research Unit,School of Health and Related Research,University of Sheffield,UK.
+ Bradburn, Michael J. Senior Medical Statistician,Clinical Trials Research Unit,School of Health and Related Research,University of Sheffield,UK.
+ McCrone, Paul. Professor of Health Economics and Director of King's Health Economics,Institute of Psychiatry, Psychology & Neuroscience,King's College London,UK.
+ Morris, Tiyi. Research Assistant,Institute of Psychiatry, Psychology & Neuroscience,King's College London,UK.
+ Edwardson, Charlotte. Associate Professor in Physical Activity, Sedentary Behaviour and Health,Diabetes Research Centre,University of Leicester,UK.
+ Barnard, Katharine. Health Psychologist and Visiting Professor,Faculty of Health and Social Science,University of Bournemouth,UK.
+ Carey, Marian E. Director: Structured Education Research Portfolio,Leicester Diabetes Centre,University Hospitals of Leicesterand Honorary Associate Professor,Diabetes Research Centre,University of Leicester,UK.
+ Davies, Melanie J. Professor of Diabetes Medicine,Diabetes Research Centre,University of Leicester,UK.
+ Dickens, Chris M. Professor of Psychological Medicine,Institute of Health Research,University of Exeter Medical School,UK.
+ Doherty, Yvonne. Consultant Clinical Psychologist and Senior Research Associate,Leicester Diabetes Centre,University Hospitals of Leicester,UK.
+ Etherington, Angela. Patient Representative,Independent Service User Consultant,UK.
+ French, Paul. Associate Director,Psychosis Research Unit,Greater Manchester Mental Health NHS Foundation Trust,UK.
+ Gaughran, Fiona. Reader,Institute of Psychiatry, Psychology & Neuroscience,King's College LondonandConsultant Psychiatrist and Director of Research, National Psychosis Service, South London and Maudsley NHS Foundation Trust,UK.
+ Greenwood, Kathryn E. Consultant Clinical Psychologist,Sussex Partnership NHS Foundation TrustandProfessor in Clinical Psychology, Sussex Psychosis Research Interest Group, School of Psychology, University of Sussex,UK.
+ Kalidindi, Sridevi. Consultant Psychiatrist, Rehabilitation and Recovery,South London and Maudsley NHS Foundation Trust and Senior Clinical Lecturer, Institute of Psychiatry, Psychology & Neuroscience, King's College London,UK.
+ Khunti, Kamlesh. Professor of Primary Care Diabetes and Vascular Medicine,Diabetes Research Centre,University of Leicester,UK.
+ Laugharne, Richard. Consultant Psychiatrist and Honorary Senior Lecturer,Cornwall Partnership NHS Foundation Trust,UK.
+ Pendlebury, John. Retired NHS Community Psychiatric Nurse,UK.
+ Rathod, Shanaya. Consultant Psychiatrist and Director of Research,Southern Health NHS Foundation TrustandVisiting Professor,Faculty of Science, University of Portsmouth,UK.
+ Saxon, David. Research Fellow,Mental Health Unit, School of Health and Related Research,University of Sheffield,UK.
+ Shiers, David. Honorary Research Consultant,Psychosis Research Unit,Greater Manchester Mental Health NHS Foundation Trust andHonorary Reader in Early Psychosis,School of Health Sciences, Division of Psychology and Mental Health,University of Manchester,UK.
+ Siddiqi, Najma. Clinical Senior Lecturer in Psychiatry,Health Sciences,University of York, Hull York Medical SchoolandConsultant Psychiatrist,Bradford District Care NHS Foundation Trust,UK.
+ Swaby, Elizabeth A. Study Manager,Clinical Trials Research Unit,School of Health and Related Research,University of Sheffield,UK.
+ Waller, Glenn. Professor of Psychology,Department of Psychology,University of Sheffield,UK.
+ Wright, Stephen. Lead Consultant, Early Intervention Psychiatry,Tees Esk & Wear Valleys NHS Foundation Trust,UK.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Cost-Benefit Analysis
+ Eating/px [Psychology]
+ Exercise
+ Female
+ Humans
+ Life Style
+ Male
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Obesity/th [Therapy]
+ *Patient Education as Topic/mt [Methods]
+ Psychotherapy, Group
+ Psychotic Disorders/bl [Blood]
+ Psychotic Disorders/co [Complications]
+ *Psychotic Disorders/th [Therapy]
+ Schizophrenia/bl [Blood]
+ Schizophrenia/co [Complications]
+ *Schizophrenia/th [Therapy]
+ Weight Loss
+Keyword Heading
+ Schizophrenia
+ antipsychotic
+ cost benefit analysis
+ exercise
+ healthy diet
+ lifestyle
+ obesity
+ overweight
+ psychosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a major challenge for people with schizophrenia.AimsWe assessed whether STEPWISE, a theory-based, group structured lifestyle education programme could support weight reduction in people with schizophrenia.
+
+ METHOD: In this randomised controlled trial (study registration: ISRCTN19447796), we recruited adults with schizophrenia, schizoaffective disorder or first-episode psychosis from ten mental health organisations in England. Participants were randomly allocated to the STEPWISE intervention or treatment as usual. The 12-month intervention comprised four 2.5 h weekly group sessions, followed by 2-weekly maintenance contact and group sessions at 4, 7 and 10 months. The primary outcome was weight change after 12 months. Key secondary outcomes included diet, physical activity, biomedical measures and patient-related outcome measures. Cost-effectiveness was assessed and a mixed-methods process evaluation was included.
+
+ RESULTS: Between 10 March 2015 and 31 March 2016, we recruited 414 people (intervention 208, usual care 206) with 341 (84.4%) participants completing the trial. At 12 months, weight reduction did not differ between groups (mean difference 0.0 kg, 95% CI -1.6 to 1.7, P = 0.963); physical activity, dietary intake and biochemical measures were unchanged. STEPWISE was well-received by participants and facilitators. The healthcare perspective incremental cost-effectiveness ratio was 246 921 per quality-adjusted life-year gained.
+
+ CONCLUSIONS: Participants were successfully recruited and retained, indicating a strong interest in weight interventions; however, the STEPWISE intervention was neither clinically nor cost-effective. Further research is needed to determine how to manage overweight and obesity in people with schizophrenia. Declaration of interest R.I.G.H. received fees for lecturing, consultancy work and attendance at conferences from the following: Boehringer Ingelheim, Eli Lilly, Janssen, Lundbeck, Novo Nordisk, Novartis, Otsuka, Sanofi, Sunovion, Takeda, MSD. M.J.D. reports personal fees from Novo Nordisk, Sanofi-Aventis, Lilly, Merck Sharp & Dohme, Boehringer Ingelheim, AstraZeneca, Janssen, Servier, Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceuticals International Inc.; and, grants from Novo Nordisk, Sanofi-Aventis, Lilly, Boehringer Ingelheim, Janssen. K.K. has received fees for consultancy and speaker for Novartis, Novo Nordisk, Sanofi-Aventis, Lilly, Servier and Merck Sharp & Dohme. He has received grants in support of investigator and investigator-initiated trials from Novartis, Novo Nordisk, Sanofi-Aventis, Lilly, Pfizer, Boehringer Ingelheim and Merck Sharp & Dohme. K.K. has received funds for research, honoraria for speaking at meetings and has served on advisory boards for Lilly, Sanofi-Aventis, Merck Sharp & Dohme and Novo Nordisk. D.Sh. is expert advisor to the NICE Centre for guidelines; board member of the National Collaborating Centre for Mental Health (NCCMH); clinical advisor (paid consultancy basis) to National Clinical Audit of Psychosis (NCAP); views are personal and not those of NICE, NCCMH or NCAP. J.P. received personal fees for involvement in the study from a National Institute for Health Research (NIHR) grant. M.E.C. and Y.D. report grants from NIHR Health Technology Assessment, during the conduct of the study; and The Leicester Diabetes Centre, an organisation (employer) jointly hosted by an NHS Hospital Trust and the University of Leicester and who is holder (through the University of Leicester) of the copyright of the STEPWISE programme and of the DESMOND suite of programmes, training and intervention fidelity framework that were used in this study. S.R. has received honorarium from Lundbeck for lecturing. F.G. reports personal fees from Otsuka and Lundbeck, personal fees and non-financial support from Sunovion, outside the submitted work; and has a family member with professional links to Lilly and GSK, including shares. F.G. is in part funded by the National Institute for Health Research Collaboration for Leadership in Applied Health Research & Care Funding scheme, by the Maudsley Charity and by the Stanley Medical Research Institute and is supported by the by the Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1192%2fbjp.2018.167
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Holt&issn=0007-1250&title=British+Journal+of+Psychiatry&atitle=Structured+lifestyle+education+for+people+with+schizophrenia%2C+schizoaffective+disorder+and+first-episode+psychosis+%28STEPWISE%29%3A+randomised+controlled+trial.&volume=214&issue=2&spage=63&epage=73&date=2019&doi=10.1192%2Fbjp.2018.167&pmid=30251622&sid=OVID:medline
+
+<1895>
+Unique Identifier
+ 30242900
+Title
+ Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon.
+Source
+ Diabetic Medicine. 36(11):1408-1411, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lundegaard Asferg C; Bjorn Andersen U; Linneberg A; Goetze JP; Holst JJ; Jeppesen JL
+Author NameID
+ Jeppesen, J L; ORCID: https://orcid.org/0000-0003-4320-8015
+Authors Full Name
+ Lundegaard Asferg, C; Bjorn Andersen, U; Linneberg, A; Goetze, J P; Holst, J J; Jeppesen, J L.
+Institution
+ Lundegaard Asferg, C. Department of Clinical Physiology, University of Copenhagen, Glostrup.
+ Bjorn Andersen, U. Department of Clinical Physiology, University of Copenhagen, Glostrup.
+ Linneberg, A. Research Centre for Prevention and Health, the Capital Region of Denmark, Rigshospitalet Glostrup, University of Copenhagen, Glostrup.
+ Linneberg, A. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.
+ Goetze, J P. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.
+ Goetze, J P. Department of Clinical Biochemistry, Rigshospitalet Blegdamsvej, University of Copenhagen, Copenhagen.
+ Holst, J J. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.
+ Holst, J J. Department of Biomedical Sciences and Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen.
+ Jeppesen, J L. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.
+ Jeppesen, J L. Department of Medicine, Amager Hvidovre Hospital in Glostrup, University of Copenhagen, Glostrup, Denmark.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Arginine Vasopressin/bl [Blood]
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Fasting/bl [Blood]
+ *Glucagon/bl [Blood]
+ *Glycopeptides/bl [Blood]
+ Humans
+ Ideal Body Weight
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+Abstract
+ AIM: To explore the association of plasma copeptin, the C-terminal portion of provasopressin and a stable surrogate marker for arginine vasopressin secretion, with plasma glucagon in obese men and men of normal weight.
+
+ METHODS: We measured fasting blood concentrations of copeptin and glucagon in 102 healthy obese men (mean +/- sd age 49.4 +/- 10.2 years) and a control group 27 healthy men of normal weight (mean +/- sd age 51.5 +/- 8.4 years). Differences between groups were evaluated using t-tests, and multiple linear regression analysis, adjusting for age and weight status (normal weight vs obese), was used to calculate unstandardized regression coefficients (beta) with 95% CIs between copeptin and glucagon. Copeptin was (natural) log-transformed.
+
+ RESULTS: The obese men had higher [median (interquartile range)] plasma copeptin concentrations [6.6 (4.6-9.5) vs 4.9 (3.5-6.8) pmol/l; P = 0.040] and higher mean +/- sd plasma glucagon concentrations (8.5 +/- 3.8 vs 5.3 +/- 1.4 pmol/l; P < 0.001) than the normal-weight men. Adjusted for age and weight status, copeptin was significantly associated with glucagon (beta = 1.35, 95% CI 0.13-2.57; P = 0.031). No significant interaction effect between copeptin and weight status on glucagon was found (P = 0.81).
+
+ CONCLUSIONS: Obese men had higher concentrations of copeptin and glucagon than men of normal weight. Copeptin was positively associated with glucagon. Our data suggest that increased arginine vasopressin-stimulated glucagon secretion might contribute to higher glucagon concentrations; therefore, increased arginine vasopressin secretion, in addition to other factors, could further aggravate the hyperglucagonaemic state found in obese individuals. Copyright © 2018 Diabetes UK.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycopeptides). 0 (copeptins). 113-79-1 (Arginine Vasopressin). 9007-92-5 (Glucagon).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fdme.13820
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lundegaard+Asferg&issn=0742-3071&title=Diabetic+Medicine&atitle=Copeptin%2C+a+surrogate+marker+for+arginine+vasopressin+secretion%2C+is+positively+associated+with+glucagon.&volume=36&issue=11&spage=1408&epage=1411&date=2019&doi=10.1111%2Fdme.13820&pmid=30242900&sid=OVID:medline
+
+<1896>
+Unique Identifier
+ 30242234
+Title
+ Plasma lipid profiling of tissue-specific insulin resistance in human obesity.
+Source
+ International Journal of Obesity. 43(5):989-998, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ van der Kolk BW; Vogelzangs N; Jocken JWE; Valsesia A; Hankemeier T; Astrup A; Saris WHM; Arts ICW; van Greevenbroek MMJ; Blaak EE
+Author NameID
+ van der Kolk, Birgitta W; ORCID: http://orcid.org/0000-0001-8608-541X
+ Valsesia, Armand; ORCID: http://orcid.org/0000-0003-0746-9664
+ Astrup, Arne; ORCID: http://orcid.org/0000-0001-8968-8996
+ Arts, Ilja C W; ORCID: http://orcid.org/0000-0001-6462-6692
+ Blaak, Ellen E; ORCID: http://orcid.org/0000-0002-2496-3464
+Corporate Author
+ DiOGenes consortium
+Authors Full Name
+ van der Kolk, Birgitta W; Vogelzangs, Nicole; Jocken, Johan W E; Valsesia, Armand; Hankemeier, Thomas; Astrup, Arne; Saris, Wim H M; Arts, Ilja C W; van Greevenbroek, Marleen M J; Blaak, Ellen E.
+Institution
+ van der Kolk, Birgitta W. Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. b.vanderkolk@maastrichtuniversity.nl.
+ Vogelzangs, Nicole. Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
+ Vogelzangs, Nicole. Department of Epidemiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
+ Vogelzangs, Nicole. Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.
+ Jocken, Johan W E. Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
+ Valsesia, Armand. Nestle Institute of Health Sciences, Lausanne, Switzerland.
+ Hankemeier, Thomas. Netherlands Metabolomics Centre, Leiden, The Netherlands.
+ Astrup, Arne. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
+ Saris, Wim H M. Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
+ Arts, Ilja C W. Department of Epidemiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
+ Arts, Ilja C W. Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.
+ van Greevenbroek, Marleen M J. Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.
+ Blaak, Ellen E. Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Chromatography, Liquid
+ Female
+ Glucose Tolerance Test
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ *Lipid Metabolism/ph [Physiology]
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Muscle, Skeletal/me [Metabolism]
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Signal Transduction
+ Young Adult
+Abstract
+ BACKGROUND/OBJECTIVES: Obesity-associated insulin resistance (IR) may develop in multiple organs, representing different aetiologies towards cardiometabolic diseases. This study aimed to identify distinct plasma lipid profiles in overweight/obese individuals who show muscle-IR and/or liver-IR.
+
+ SUBJECTS/METHODS: Baseline data of the European multicenter DiOGenes project were used (n = 640; 401 women, nondiabetic BMI: 27-45 kg/m2). Muscle insulin sensitivity index (MISI) and hepatic insulin resistance index (HIRI) were derived from a 5-point oral glucose tolerance test. The 140 plasma lipids were quantified by liquid chromatography-mass spectrometry. Linear mixed models were used to evaluate associations between MISI, HIRI and plasma lipids.
+
+ RESULTS: MISI was comparable between sexes while HIRI and triacylglycerol (TAG) levels were lower in women than in men. MISI was associated with higher lysophosphatidylcholine (LPC) levels (standardized (std)beta = 0.126; FDR-p = 0.032). Sex interactions were observed for associations between HIRI, TAG and diacylglycerol (DAG) lipid classes. In women, but not in men, HIRI was associated with higher levels of TAG (44 out of 55 species) and both DAG species (stdbeta: 0.139-0.313; FDR-p < 0.05), a lower odd-chain/even-chain TAG ratio (stdbeta = -0.182; FDR-p = 0.005) and a lower very-long-chain/long-chain TAG ratio (stdbeta = -0.156; FDR-p = 0.037).
+
+ CONCLUSIONS: In overweight/obese individuals, muscle insulin sensitivity is associated with higher plasma LPC concentrations. Women have less hepatic IR and lower TAG than men. Nevertheless, hepatic IR is associated with higher plasma TAG and DAG concentrations and a lower abundance of odd-chain and very-long-chain TAG in women, but not in men. This suggests a more pronounced worsening of plasma lipid profile in women with the progression of hepatic IR.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0189-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=van+der+Kolk&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Plasma+lipid+profiling+of+tissue-specific+insulin+resistance+in+human+obesity.&volume=43&issue=5&spage=989&epage=998&date=2019&doi=10.1038%2Fs41366-018-0189-8&pmid=30242234&sid=OVID:medline
+
+<1897>
+Unique Identifier
+ 30240938
+Title
+ The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis.
+Source
+ Osteoarthritis & Cartilage. 27(1):129-139, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Guss JD; Ziemian SN; Luna M; Sandoval TN; Holyoak DT; Guisado GG; Roubert S; Callahan RL; Brito IL; van der Meulen MCH; Goldring SR; Hernandez CJ
+Authors Full Name
+ Guss, J D; Ziemian, S N; Luna, M; Sandoval, T N; Holyoak, D T; Guisado, G G; Roubert, S; Callahan, R L; Brito, I L; van der Meulen, M C H; Goldring, S R; Hernandez, C J.
+Institution
+ Guss, J D. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
+ Ziemian, S N. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
+ Luna, M. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
+ Sandoval, T N. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
+ Holyoak, D T. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
+ Guisado, G G. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
+ Roubert, S. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
+ Callahan, R L. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
+ Brito, I L. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
+ van der Meulen, M C H. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA; Hospital for Special Surgery, New York, NY, USA.
+ Goldring, S R. Hospital for Special Surgery, New York, NY, USA.
+ Hernandez, C J. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA; Hospital for Special Surgery, New York, NY, USA. Electronic address: cjh275@cornell.edu.
+MeSH Subject Headings
+ Adipose Tissue/pa [Pathology]
+ Animals
+ *Arthritis, Experimental/et [Etiology]
+ Arthritis, Experimental/mi [Microbiology]
+ Arthritis, Experimental/pa [Pathology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Cartilage, Articular/pa [Pathology]
+ Cytokines/bl [Blood]
+ *Gastrointestinal Microbiome
+ Inflammation Mediators/bl [Blood]
+ Lipopolysaccharides/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/co [Complications]
+ Mice, Inbred C57BL
+ Mice, Knockout
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ *Osteoarthritis/et [Etiology]
+ Osteoarthritis/mi [Microbiology]
+ Osteoarthritis/pa [Pathology]
+ Toll-Like Receptor 5/df [Deficiency]
+ Toll-Like Receptor 5/ge [Genetics]
+ Weight-Bearing/ph [Physiology]
+Keyword Heading
+ Bone
+ Gut microbiome
+ Inflammation
+ Mechanical loads
+ Obesity
+ Osteoarthritis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Metabolic syndrome is characterized by obesity, hyperglycemia, hypertension, insulin resistance, and dyslipidemia. Metabolic syndrome is associated with osteoarthritis (OA), but it is unclear if the association is attributable to increased mechanical loading on joints caused by obesity or other aspects of metabolic syndrome. Here we examined the effects of altered metabolism, obesity, and the gut microbiome on load-induced OA.
+
+ DESIGN: Cartilage damage was induced through cyclic compressive loading in four groups of adult male mice: Toll-like receptor-5 deficient (TLR5KO) mice that develop metabolic syndrome due to alterations in the gut microbiome, TLR5KO mice submitted to chronic antibiotics to prevent metabolic syndrome (TLR5KODELTAMicrobiota), C57BL/6J mice fed a high fat diet to cause obesity (HFD), and untreated C57BL/6J mice (WT). Loading was applied for 2 weeks (n = 10-11/group) or 6 weeks (n = 10-11/group).
+
+ RESULTS: After 2 weeks of loading, cartilage damage (OARSI score) was not different among groups. After 6 weeks of loading, HFD mice had increased load-induced cartilage damage, while TLR5KO mice had cartilage damage comparable to WT mice. TLR5KODELTAMicrobiota mice had less cartilage damage than other groups. HFD mice had elevated serum inflammatory markers. Each group had a distinct gut microbiome composition.
+
+ CONCLUSIONS: Severe obesity increased load-induced cartilage damage, while milder changes in adiposity/metabolic syndrome seen in TLR5KO mice did not. Furthermore, the effects of systemic inflammation/obesity on cartilage damage depend on the duration of mechanical loading. Lastly, reduced cartilage damage in the TLR5KODELTAMicrobiota mice suggests that the gut microbiome may influence cartilage pathology. Copyright © 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators). 0 (Lipopolysaccharides). 0 (Tlr5 protein, mouse). 0 (Toll-Like Receptor 5).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.joca.2018.07.020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Guss&issn=1063-4584&title=Osteoarthritis+%26+Cartilage&atitle=The+effects+of+metabolic+syndrome%2C+obesity%2C+and+the+gut+microbiome+on+load-induced+osteoarthritis.&volume=27&issue=1&spage=129&epage=139&date=2019&doi=10.1016%2Fj.joca.2018.07.020&pmid=30240938&sid=OVID:medline
+
+<1898>
+Unique Identifier
+ 30219816
+Title
+ Serum Lipopolysaccharide-Binding Protein is Associated with Chronic Inflammation and Metabolic Syndrome in Hemodialysis Patients.
+Source
+ Blood Purification. 47(1-3):28-36, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lim PS; Chang YK; Wu TK
+Authors Full Name
+ Lim, Paik Seong; Chang, Yu-Kang; Wu, Tsai-Kun.
+Institution
+ Lim, Paik Seong. Division of Renal Medicine, Tungs' Taichung Metroharbour Hospital, Taichung, Taiwanjamespslim@gmail.com.
+ Lim, Paik Seong. Department of Nursing and Rehabilitation, Jenteh Junior College of Medicine, Nursing and Management, Miaoli, Taiwanjamespslim@gmail.com.
+ Lim, Paik Seong. Department of Internal Medicine, Taipei Medical University, Taipei, Taiwanjamespslim@gmail.com.
+ Chang, Yu-Kang. Division of Epidemiology and Biostatistics, Department of Medical Research, Tungs' Taichung Metroharbour Hospital, Taichung, Taiwan.
+ Wu, Tsai-Kun. Division of Renal Medicine, Tungs' Taichung Metroharbour Hospital, Taichung, Taiwan.
+MeSH Subject Headings
+ Acute-Phase Proteins
+ Aged
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/co [Complications]
+ Cardiovascular Diseases/th [Therapy]
+ *Cardiovascular Diseases
+ *Carrier Proteins/bl [Blood]
+ Chronic Disease
+ Cross-Sectional Studies
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/th [Therapy]
+ Interleukin-6/bl [Blood]
+ Lipopolysaccharide Receptors/bl [Blood]
+ Male
+ *Membrane Glycoproteins/bl [Blood]
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/co [Complications]
+ Metabolic Syndrome/th [Therapy]
+ *Metabolic Syndrome
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ *Obesity
+ *Renal Dialysis
+Keyword Heading
+ Hemodialysis
+ Inflammation
+ Lipopolysaccharide-binding protein
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: In hemodialysis (HD) patients, impaired gut barrier and alteration in microbiota in the gut is thought to increase the risk of bacterial translocation and chronic inflammation. Lipopolysaccharide-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by microbial products. Our aim is to investigate the relationship between circulating levels of LBP, and various metabolic and inflammatory markers in HD patients. Besides, we also aim to determine its relationship among -patients with different body mass index.
+
+ PATIENTS AND METHODS: A total of 123 HD patients were stratified into three -tertiles, according to serum LBP level. The LBP and inflammatory markers were determined using immunoassay methods. A bioimpedance spectroscopy device was used for body composition measurement.
+
+ RESULTS: The serum levels of the two proinflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin (IL)-6, were significantly higher in patients in the upper tertile when compared with the rest of the tertiles. In HD patients, a significant positive correlation was found between serum LBP levels and CRP, IL-6, soluble CD14 (sCD14), and fasting blood glucose levels. Patients with metabolic syndrome and pre-existing cardiovascular disease had higher LBP levels than those without metabolic syndrome. Besides, obese patients were also associated with higher serum LBP levels. Multivariate regression analyses showed that IL-6 level was the strongest correlate of LBP level, followed by hsCRP level and sCD14.
+
+ CONCLUSIONS: Our study suggested that elevated plasma LBP was associated with metabolic syndrome and obesity. In addition, increased LBP level was correlated positively to markers of inflammation, and sCD14 levels. Copyright © 2018 S. Karger AG, Basel.
+Registry Number/Name of Substance
+ 0 (Acute-Phase Proteins). 0 (Biomarkers). 0 (Carrier Proteins). 0 (IL6 protein, human). 0 (Interleukin-6). 0 (Lipopolysaccharide Receptors). 0 (Membrane Glycoproteins). 0 (lipopolysaccharide-binding protein). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1159%2f000492778
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lim&issn=0253-5068&title=Blood+Purification&atitle=Serum+Lipopolysaccharide-Binding+Protein+is+Associated+with+Chronic+Inflammation+and+Metabolic+Syndrome+in+Hemodialysis+Patients.&volume=47&issue=1-3&spage=28&epage=36&date=2019&doi=10.1159%2F000492778&pmid=30219816&sid=OVID:medline
+
+<1899>
+Unique Identifier
+ 30219609
+Title
+ Relationship between dietary quality, determined by DASH score, and cardiometabolic health biomarkers: A cross-sectional analysis in adults.
+Source
+ Clinical Nutrition. 38(4):1620-1628, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Phillips CM; Harrington JM; Perry IJ
+Authors Full Name
+ Phillips, Catherine M; Harrington, Janas M; Perry, Ivan J.
+Institution
+ Phillips, Catherine M. HRB Centre for Diet and Health Research, School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Dublin 4, Ireland; HRB Centre for Diet and Health Research, School of Public Health, University College Cork, Western Gateway Building, Western Rd., Cork, Ireland. Electronic address: catherine.phillips@ucd.ie.
+ Harrington, Janas M. HRB Centre for Diet and Health Research, School of Public Health, University College Cork, Western Gateway Building, Western Rd., Cork, Ireland.
+ Perry, Ivan J. HRB Centre for Diet and Health Research, School of Public Health, University College Cork, Western Gateway Building, Western Rd., Cork, Ireland.
+MeSH Subject Headings
+ Biomarkers
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ *Cytokines/bl [Blood]
+ *Diet/sn [Statistics & Numerical Data]
+ Female
+ Humans
+ Inflammation
+ Insulin Resistance
+ Ireland/ep [Epidemiology]
+ Lipoproteins/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+Keyword Heading
+ Biomarkers
+ Dietary quality
+ Inflammation
+ Insulin resistance
+ Lipoproteins
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: The relationship between dietary patterns and cardiometabolic disease is of increasing interest. However, limited data regarding the association between dietary quality and biomarkers of cardiometabolic health exist. Therefore the aim of this work was to examine potential associations between dietary quality, assessed using the Dietary Approaches to Stop Hypertension (DASH) dietary quality score, adiposity and biomarkers of glucose homeostasis, lipoprotein metabolism and inflammation in a cross-sectional sample of 1493 men and women.
+
+ METHODS: Anthropometric measurements included BMI, hip and waist circumference (WC). Serum acute-phase reactants, adipocytokines, pro-inflammatory cytokines and white blood cell (WBC) counts were determined. Lipoprotein particle size and subclass concentrations were measured using nuclear magnetic resonance (NMR) spectroscopy. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR).
+
+ RESULTS: Higher dietary quality was associated with lower BMI (P < 0.05), WC (P < 0.001), tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), WBC and plasminogen activator inhibitor-1 (PAI-1) concentrations (P < 0.01) and reduced insulin resistance (P < 0.05). In addition less small low density lipoprotein (LDL) and small high density lipoprotein (HDL) particles and less large very low density lipoprotein (VLDL) particles were observed among those with better dietary quality (P < 0.001). Individuals in the top DASH quartile had a 54% and 48% lower likelihood of central obesity and metabolic syndrome (MetS), respectively, than those in the lowest DASH quartile (P < 0.05).
+
+ CONCLUSIONS: Our data suggest that higher quality diet is associated with improved adiposity measures and a less insulin resistant, pro-inflammatory, pro-thrombotic and pro-atherogenic cardiometabolic profile which may impact on central obesity and MetS risk. These findings, which may be of clinical and public health significance in terms of dietary approaches to promote cardiometabolic health, warrant further examination. Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cytokines). 0 (Lipoproteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.clnu.2018.08.028
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Phillips&issn=0261-5614&title=Clinical+Nutrition&atitle=Relationship+between+dietary+quality%2C+determined+by+DASH+score%2C+and+cardiometabolic+health+biomarkers%3A+A+cross-sectional+analysis+in+adults.&volume=38&issue=4&spage=1620&epage=1628&date=2019&doi=10.1016%2Fj.clnu.2018.08.028&pmid=30219609&sid=OVID:medline
+
+<1900>
+Unique Identifier
+ 30212233
+Title
+ Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice.
+Source
+ Chronobiology International. 36(1):57-74, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Okauchi H; Hashimoto C; Nakao R; Oishi K
+Author NameID
+ Oishi, Katsutaka; ORCID: https://orcid.org/0000-0002-4870-0837
+Authors Full Name
+ Okauchi, Hiroki; Hashimoto, Chiaki; Nakao, Reiko; Oishi, Katsutaka.
+Institution
+ Okauchi, Hiroki. a Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
+ Okauchi, Hiroki. b Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Japan.
+ Hashimoto, Chiaki. a Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
+ Hashimoto, Chiaki. b Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Japan.
+ Nakao, Reiko. a Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
+ Oishi, Katsutaka. a Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
+ Oishi, Katsutaka. b Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Japan.
+ Oishi, Katsutaka. c Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
+ Oishi, Katsutaka. d School of Integrative and Global Majors (SIGMA), University of Tsukuba, Tsukuba, Japan.
+MeSH Subject Headings
+ Activity Cycles
+ Adiposity
+ *Animal Nutritional Physiological Phenomena
+ Animals
+ Biomarkers/bl [Blood]
+ *Circadian Rhythm
+ *Diet, High-Fat
+ *Dietary Sucrose
+ Disease Models, Animal
+ *Eating
+ Energy Metabolism
+ *Feeding Behavior
+ Male
+ *Meals
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ *Obesity/pc [Prevention & Control]
+ Obesity/px [Psychology]
+ *Physical Exertion
+ Running
+ Sedentary Behavior
+ Time Factors
+ Volition
+ Weight Gain
+Keyword Heading
+ Feeding rhythm
+ adiposity
+ circadian clock
+ lipogenesis
+ obesity
+ voluntary exercise
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Inappropriate eating habits such as skipping breakfast and eating late at night are associated with risk for abnormal weight-gain and adiposity. We previously reported that time-imposed feeding during the daytime (inactive phase) induces obesity and metabolic disorders accompanied by physical inactivity in mice. The present study compares metabolic changes induced in mice by time-imposed feeding under voluntary wheel-running (RW) and sedentary (SED) conditions to determine the effects of voluntary wheel-running activity on obesity induced in mice by feeding at inappropriate times. Mice were individually housed in cages with or without running-wheels. We compared food consumption, core body temperature, hormonal and metabolic variables in the blood, lipid accumulation in the liver, circadian expression of clock and metabolic genes in peripheral tissues, and gains in body weight between mice allowed access to food only during the sleep phase (daytime feeding; DF) or only during the active phase (nighttime feeding; NF) under SED or RW conditions. Only a high-fat high-sucrose diet was available to the mice throughout restricted feeding. Nocturnal activity was maintained in both NF and DF mice under RW conditions, but significantly suppressed during the latter half of the dark phase in DF mice. Nocturnal fluctuations in core body temperature were maintained in DF and NF mice under both SED and RW conditions, although DF attenuated the day-night amplitude more under SED, than RW conditions. The degrees of DF-induced increases in body weight gain, food efficiency, adipose tissue mass, lipogenic gene expression in metabolic tissues, and hepatic lipid accumulation were essentially identical between SED and RW conditions. Daytime feeding also induced hyperinsulinemia and hyperleptinemia under both SED and RW conditions, although DF-induced hyperleptinemia was slightly attenuated by wheel-running. The temporal expression of circadian clock genes became synchronized to feeding cycles in the liver but not in the skeletal muscle of mice under both SED and RW conditions. Chronic voluntary exercise on running-wheels minimally affected obesity and adiposity in mice caused by daily feeding at unusual times. The timing of food intake might be more important than physical exercise for preventing metabolic disorders. Abbreviations: ANOVA: analysis of variance; DF: daytime feeding; FFA: free fatty acid; GLP-1: glucagon-like peptide-1; HOMA-IR: homeostasis model assessment of insulin resistance; NEAT: non-exercise activity thermogenesis; NF: nighttime feeding; RF: restricted feeding; RW: running-wheel; SCN: suprachiasmatic nucleus; SE: standard error of the mean; SED: sedentary; SPA: spontaneous physical activity; T-Cho: total cholesterol; TG: triglyceride; WAT: white adipose tissues.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Sucrose).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f07420528.2018.1516672
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Okauchi&issn=0742-0528&title=Chronobiology+International&atitle=Timing+of+food+intake+is+more+potent+than+habitual+voluntary+exercise+to+prevent+diet-induced+obesity+in+mice.&volume=36&issue=1&spage=57&epage=74&date=2019&doi=10.1080%2F07420528.2018.1516672&pmid=30212233&sid=OVID:medline
+
+<1901>
+Unique Identifier
+ 30206337
+Title
+ Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function.
+Source
+ International Journal of Obesity. 43(8):1611-1619, 2019 08.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Comas F; Lluch A; Sabater M; Latorre J; Ortega F; Ricart W; Lopez M; Fernandez-Real JM; Moreno-Navarrete JM
+Author NameID
+ Ortega, Francisco; ORCID: http://orcid.org/0000-0003-2111-769X
+ Lopez, Miguel; ORCID: http://orcid.org/0000-0002-7823-1648
+Authors Full Name
+ Comas, Ferran; Lluch, Aina; Sabater, Monica; Latorre, Jessica; Ortega, Francisco; Ricart, Wifredo; Lopez, Miguel; Fernandez-Real, Jose Manuel; Moreno-Navarrete, Jose Maria.
+Institution
+ Comas, Ferran. Department of Diabetes, Endocrinology and Nutrition Institut d'Investigacio Biomedica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
+ Lluch, Aina. Department of Diabetes, Endocrinology and Nutrition Institut d'Investigacio Biomedica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
+ Sabater, Monica. Department of Diabetes, Endocrinology and Nutrition Institut d'Investigacio Biomedica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
+ Latorre, Jessica. Department of Diabetes, Endocrinology and Nutrition Institut d'Investigacio Biomedica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
+ Ortega, Francisco. Department of Diabetes, Endocrinology and Nutrition Institut d'Investigacio Biomedica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
+ Ricart, Wifredo. Department of Diabetes, Endocrinology and Nutrition Institut d'Investigacio Biomedica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
+ Lopez, Miguel. NeurObesity Group, Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigacion Sanitaria, Santiago de Compostela, 15782, Spain & CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Santiago de Compostela, 15706, Spain.
+ Fernandez-Real, Jose Manuel. Department of Diabetes, Endocrinology and Nutrition Institut d'Investigacio Biomedica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain. jmfreal@idibgi.org.
+ Moreno-Navarrete, Jose Maria. Department of Diabetes, Endocrinology and Nutrition Institut d'Investigacio Biomedica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain. jmoreno@idibgi.org.
+MeSH Subject Headings
+ *Adipocytes/me [Metabolism]
+ Adipogenesis
+ *Adipose Tissue/me [Metabolism]
+ Adult
+ Biomarkers/me [Metabolism]
+ Cells, Cultured
+ Cellular Senescence
+ Cohort Studies
+ Fatty Acids/me [Metabolism]
+ Female
+ Gene Expression
+ Humans
+ Inflammation/me [Metabolism]
+ Intra-Abdominal Fat/me [Metabolism]
+ Male
+ Middle Aged
+ *Mitochondria/me [Metabolism]
+ Obesity/ge [Genetics]
+ Obesity/me [Metabolism]
+ Subcutaneous Fat/me [Metabolism]
+ Thyrotropin Alfa/me [Metabolism]
+ *Thyrotropin, beta Subunit/ge [Genetics]
+ *Thyrotropin, beta Subunit/me [Metabolism]
+Abstract
+ BACKGROUND/OBJECTIVES: Recent studies indicate a possible role of TSH/TSHR signalling axis on adipogenesis and adipose tissue physiology. Here, we aimed to investigate the relationship between adipose tissue TSHB and adipose tissue physiology-related gene expression.
+
+ SUBJECTS/METHODS: Subcutaneous and visceral adipose tissue TSHB gene expression was analysed in two independent cohorts [Cohort1 (N = 96) and Cohort2 (N = 45)] and after bariatric surgery-induced weight loss [Cohort3 (N = 22)]. Adipose tissue TSH protein expression was also analysed in a subgroup of participants from Cohort 1 (N = 16). The effects of recombinant TSH on human subcutaneous preadipocytes and adipocytes were investigated.
+
+ RESULTS: In cohort 1, both visceral and subcutaneous adipose tissue TSHB gene expression was positively correlated with the expression of mitochondrial function (PPARGC1A, ISCA2, CISD1, SIRT1, NFE2L2, NRF1) and fatty acid mobilization (CAV1, ENGL1), but not with adipogenic-related genes. Of note, adipose tissue TSH protein levels were also associated with some of these markers of mitochondrial function and fatty acid mobilization. These associations were replicated in cohort 2. Bariatric surgery-induced weight loss resulted in increased subcutaneous adipose tissue TSHB in parallel to increased PPARGC1A. In human subcutaneous adipocytes, rh-TSH administration led to increased mitochondrial respiratory capacity in parallel to increased mitochondrial function- and adipogenic-related gene expression, but no significant effects were observed during differentiation of human preadipocytes.
+
+ CONCLUSION: These data point to a possible role of adipose tissue TSH in the maintenance of adipocyte mitochondrial function.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids). 0 (Thyrotropin Alfa). 0 (Thyrotropin, beta Subunit).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0203-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Comas&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Adipose+tissue+TSH+as+a+new+modulator+of+human+adipocyte+mitochondrial+function.&volume=43&issue=8&spage=1611&epage=1619&date=2019&doi=10.1038%2Fs41366-018-0203-1&pmid=30206337&sid=OVID:medline
+
+<1902>
+Unique Identifier
+ 30178443
+Title
+ Influence of skeletal muscle mass and fat mass on the metabolic and inflammatory profile in sarcopenic and non-sarcopenic overfat elderly.
+Source
+ Aging-Clinical & Experimental Research. 31(5):629-635, 2019 May.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rossi FE; Lira FS; Silva BSA; Freire APCF; Ramos EMC; Gobbo LA
+Authors Full Name
+ Rossi, Fabricio E; Lira, Fabio S; Silva, Bruna S A; Freire, Ana Paula C F; Ramos, Ercy M C; Gobbo, Luis A.
+Institution
+ Rossi, Fabricio E. Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piaui (UFPI), Teresina, PI, Brazil.
+ Lira, Fabio S. Exercise and Immunometabolism Research Group, School of Technology and Science, Sao Paulo State University (UNESP), Presidente Prudente, SP, Brazil.
+ Silva, Bruna S A. Laboratory of Skeletal Muscle Assessment (LABSIM), Post-graduation Program in Movement Sciences, School of Technology and Science, Sao Paulo State University (UNESP), Rua Roberto Simonsen, 305, CEP 19.060-900, Presidente Prudente, SP, Brazil.
+ Freire, Ana Paula C F. Department of Physiotherapy, School of Technology and Science, Sao Paulo State University (UNESP), Presidente Prudente, Sao Paulo, Brazil.
+ Ramos, Ercy M C. Department of Physiotherapy, School of Technology and Science, Sao Paulo State University (UNESP), Presidente Prudente, Sao Paulo, Brazil.
+ Gobbo, Luis A. Laboratory of Skeletal Muscle Assessment (LABSIM), Post-graduation Program in Movement Sciences, School of Technology and Science, Sao Paulo State University (UNESP), Rua Roberto Simonsen, 305, CEP 19.060-900, Presidente Prudente, SP, Brazil. luisgobbo@fct.unesp.br.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ *Adipose Tissue/ph [Physiology]
+ Aged
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ Humans
+ Leptin/bl [Blood]
+ Male
+ *Muscle Strength/ph [Physiology]
+ *Muscle, Skeletal/ph [Physiology]
+ *Obesity/co [Complications]
+ Plasminogen Activator Inhibitor 1/bl [Blood]
+ Sarcopenia/bl [Blood]
+ *Sarcopenia/co [Complications]
+Keyword Heading
+ Elderly
+ Inflammation
+ Sarcopenic
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Sarcopenic elderly present low muscle mass and strength, however, it is not clear if the inflammatory and metabolic profile is more related to low lean mass or high fat mass in sarcopenic and non-sarcopenic overfat elderly.
+
+ AIM: To verify the difference in inflammatory and metabolic responses in sarcopenic and non-sarcopenic overfat elderly and the relationship between these markers, body composition, and strength in this population.
+
+ METHODS: Fifty-seven elderly were divided into two groups: sarcopenic (n = 30) and non-sarcopenic (n = 27). Body composition was evaluated with octopolar bioimpedance. Total cholesterol, high-density lipoprotein cholesterol, triacylglycerol, glucose, cortisol, leptin, adiponectin, Plasminogen activator inhibitor-1 (PAI-1), TNF-alpha, IL-6, IL-8, and IL-10 were assessed. The handgrip test was used to evaluate strength.
+
+ RESULTS: When comparing the inflammatory profile, sarcopenic individuals showed greater adiponectin concentration (p = 0.019), adiponectin/fat mass ratio (p < 0.001), adiponectin/visceral fat (p < 0.001), and higher PAI-1 (p = 0.019) than non-sarcopenic overfat elderly. After adjusting the inflammatory profile by skeletal muscle mass the significant differences between groups were maintained (p < 0.05) but no significant differences between groups were observed when adjusting by fat mass, despite a tendency to a significant difference for adiponectin concentration (p = 0.06). In addition, after adjusting leptin by fat mass there was a statistically significant lower concentration in the sarcopenic compared to non-sarcopenic overfat elderly.
+
+ CONCLUSION: Non-sarcopenic overfat elderly presented lower anti-inflammatory and anti-atherogenic responses than sarcopenic elderly. Furthermore, fat mass but not skeletal muscle mass seem to change these responses.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Leptin). 0 (Plasminogen Activator Inhibitor 1). 0 (SERPINE1 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs40520-018-1029-3
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rossi&issn=1594-0667&title=Aging-Clinical+%26+Experimental+Research&atitle=Influence+of+skeletal+muscle+mass+and+fat+mass+on+the+metabolic+and+inflammatory+profile+in+sarcopenic+and+non-sarcopenic+overfat+elderly.&volume=31&issue=5&spage=629&epage=635&date=2019&doi=10.1007%2Fs40520-018-1029-3&pmid=30178443&sid=OVID:medline
+
+<1903>
+Unique Identifier
+ 30136029
+Title
+ Carnosine supplementation reduces plasma soluble transferrin receptor in healthy overweight or obese individuals: a pilot randomised trial.
+Source
+ Amino Acids. 51(1):73-81, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baye E; Ukropec J; de Courten MPJ; Kurdiova T; Krumpolec P; Fernandez-Real JM; Aldini G; Ukropcova B; de Courten B
+Authors Full Name
+ Baye, Estifanos; Ukropec, Jozef; de Courten, Maximilian P J; Kurdiova, Timea; Krumpolec, Patrick; Fernandez-Real, Jose-Manuel; Aldini, Giancarlo; Ukropcova, Barbara; de Courten, Barbora.
+Institution
+ Baye, Estifanos. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, 43-51 Kanooka Grove, Clayton, Melbourne, VIC, 3168, Australia.
+ Ukropec, Jozef. Institute of Experimental Endocrinology, Biomedical Research Centre, Slovak Academy of Sciences, Bratislava, Slovakia.
+ de Courten, Maximilian P J. Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Australia.
+ Kurdiova, Timea. Institute of Experimental Endocrinology, Biomedical Research Centre, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Krumpolec, Patrick. Institute of Experimental Endocrinology, Biomedical Research Centre, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Fernandez-Real, Jose-Manuel. Department of Diabetes, Endocrinology and Nutrition, Biomedical Research Institute of Girona (IDIBGI), Girona, Spain.
+ Aldini, Giancarlo. Department of Pharmaceutical Sciences, Universita degli Studi di Milano, Milan, Italy.
+ Ukropcova, Barbara. Institute of Experimental Endocrinology, Biomedical Research Centre, Slovak Academy of Sciences, Bratislava, Slovakia.
+ Ukropcova, Barbara. Institute of Pathological Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
+ Ukropcova, Barbara. Faculty of Physical Education and Sports, Comenius University, Bratislava, Slovakia.
+ de Courten, Barbora. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, 43-51 Kanooka Grove, Clayton, Melbourne, VIC, 3168, Australia. barbora.decourten@monash.edu.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ *Carnosine/ad [Administration & Dosage]
+ Carnosine/pd [Pharmacology]
+ *Chelating Agents/ad [Administration & Dosage]
+ Chelating Agents/pd [Pharmacology]
+ *Dietary Supplements
+ Female
+ Ferritins/bl [Blood]
+ Humans
+ Insulin Resistance
+ *Iron/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/dt [Drug Therapy]
+ Overweight/bl [Blood]
+ *Overweight/dt [Drug Therapy]
+ Pilot Projects
+ *Receptors, Transferrin/bl [Blood]
+ Transferrin/me [Metabolism]
+Keyword Heading
+ Carnosine
+ Insulin resistance
+ Iron metabolism
+ Soluble transferrin receptor
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Abnormalities of iron homeostasis have been linked to insulin resistance, type 2 diabetes and cardiovascular disease. Carnosine, an over-the-counter food supplement with chelating properties, has been shown to decrease serum iron and improve glucose metabolism in diabetic rodents. We have previously demonstrated that carnosine supplementation prevented worsening of glucose metabolism in healthy overweight and obese middle-aged adults. Yet, the impact of carnosine on markers of iron metabolism in humans has not been investigated. We aimed to determine whether carnosine supplementation has an effect on iron parameters in overweight and obese, otherwise healthy adults. We included 26 participants, who were randomly allocated to receive 1 g carnosine (n = 14) or identical placebo (n = 12) twice daily for 12 weeks. Iron parameters including iron, ferritin, transferrin, soluble transferrin receptor, total iron binding capacity and iron saturation were measured in serum or plasma by standard commercial assays. Carnosine supplementation decreased plasma soluble transferrin receptor compared to placebo (mean change difference +/- standard error: - 0.07 +/- 0.03 mg/l, p = 0.04). None of the other iron parameters were different between carnosine and placebo groups. At follow-up, soluble transferrin receptor was associated inversely with urinary carnosine concentrations and positively with serum carnosinase-1 activity (both p < 0.02). Our findings suggest that carnosine may modulate iron metabolism in high-risk groups which could ameliorate insulin resistance and prevent type 2 diabetes. Larger human clinical trials are required to confirm our results.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Chelating Agents). 0 (Receptors, Transferrin). 0 (Transferrin). 8HO6PVN24W (Carnosine). 9007-73-2 (Ferritins). E1UOL152H7 (Iron).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00726-018-2623-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baye&issn=0939-4451&title=Amino+Acids&atitle=Carnosine+supplementation+reduces+plasma+soluble+transferrin+receptor+in+healthy+overweight+or+obese+individuals%3A+a+pilot+randomised+trial.&volume=51&issue=1&spage=73&epage=81&date=2019&doi=10.1007%2Fs00726-018-2623-6&pmid=30136029&sid=OVID:medline
+
+<1904>
+Unique Identifier
+ 30132289
+Title
+ Association of OPG-RANKL ratio with left ventricular hypertrophy and geometric remodeling in male overweight/obese youths.
+Source
+ Journal of Endocrinological Investigation. 42(4):427-434, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zampetti S; Lucantoni F; Pacifico L; Campagna G; Versacci P; Pierimarchi P; Buzzetti R
+Authors Full Name
+ Zampetti, S; Lucantoni, F; Pacifico, L; Campagna, G; Versacci, P; Pierimarchi, P; Buzzetti, R.
+Institution
+ Zampetti, S. Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
+ Lucantoni, F. Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
+ Pacifico, L. Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
+ Campagna, G. Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
+ Versacci, P. Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
+ Pierimarchi, P. Institute of Translational Pharmacology, National Research Council, Rome, Italy.
+ Buzzetti, R. Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy. raffaella.buuzzetti@uniroma1.it.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ Child
+ Female
+ Humans
+ Hypertrophy, Left Ventricular/bl [Blood]
+ *Hypertrophy, Left Ventricular/di [Diagnosis]
+ Hypertrophy, Left Ventricular/et [Etiology]
+ Male
+ *Obesity/co [Complications]
+ *Osteoprotegerin/bl [Blood]
+ *Overweight/co [Complications]
+ Prognosis
+ *RANK Ligand/bl [Blood]
+ Sex Factors
+Keyword Heading
+ Left ventricular hypertrophy
+ Osteoprotegerin
+ Pediatric obesity
+ Receptor activator of nuclear factor kappa B
+ Receptor activator of nuclear factor kappa B ligand
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin (RANKL/RANK/OPG) axis has been hypothesized as a potential mediator of left ventricular hypertrophy (LVH). The aim of the study was to assess whether circulating concentrations of RANKL, RANK, and OPG were associated with early signs of morphological cardiac changes in overweight/obese youths.
+
+ METHODS: We determined serum levels of RANKL, RANK and OPG by enzyme-linked immunosorbent assays in 188 overweight/obese children and adolescents. LV mass index (LVMI) and relative wall thickness (RWT) were estimated using M-mode echocardiography.
+
+ RESULTS: OPG and RANKL levels were higher among girls than among boys [1.73 (1.64-1.86) and 3.28 (1.90-6.37) pmol/L, respectively, vs. 1.69 (1.59-1.82) and 2.12 (1.52-3.80) pmol/L; p = 0.02 and p = 0.0001, respectively], but the OPG/RANKL ratio was lower [0.52 (0.26-0.88) vs 0.77 (0.44-1.11); p = 0.001]. In gender-specific multivariate linear regression, OPG/RANKL ratio was associated with LVMI and RWT in boys but not in girls. In multiple logistic regression, after adjustment for clinical variables, OPG/RANKL ratio was associated with concentric remodeling, eccentric and concentric LVH in boys but not in girls.
+
+ CONCLUSION: OPG/RANKL ratio is independently associated with LVH and patterns of LV structural remodeling in male overweight/obese children and adolescents.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Osteoprotegerin). 0 (RANK Ligand). 0 (TNFRSF11B protein, human). 0 (TNFSF11 protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs40618-018-0932-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zampetti&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Association+of+OPG-RANKL+ratio+with+left+ventricular+hypertrophy+and+geometric+remodeling+in+male+overweight%2Fobese+youths.&volume=42&issue=4&spage=427&epage=434&date=2019&doi=10.1007%2Fs40618-018-0932-y&pmid=30132289&sid=OVID:medline
+
+<1905>
+Unique Identifier
+ 30130326
+Title
+ Obesity and Metabolic Syndrome in Kidney Transplantation: The Role of Dietary Fructose and Systemic Endotoxemia.
+Source
+ Transplantation. 103(1):191-201, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chan W; Smith B; Stegall M; Borrows R
+Authors Full Name
+ Chan, Winnie; Smith, Byron; Stegall, Mark; Borrows, Richard.
+Institution
+ Chan, Winnie. Department of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, United Kingdom.
+ Chan, Winnie. Department of Nutrition and Dietetics, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, United Kingdom.
+ Smith, Byron. Division of Biomedical Statistics & Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
+ Stegall, Mark. Division of Transplantation Surgery, Department of Medicine, Mayo Clinic, Rochester, MN.
+ Stegall, Mark. The William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.
+ Borrows, Richard. Department of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, United Kingdom.
+ Borrows, Richard. School of Infection and Immunity. University of Birmingham, Edgbaston, Birmingham, United Kingdom.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Cross-Sectional Studies
+ *Dietary Sugars/ae [Adverse Effects]
+ Endotoxemia/bl [Blood]
+ Endotoxemia/di [Diagnosis]
+ *Endotoxemia/ep [Epidemiology]
+ Endotoxins/bl [Blood]
+ England/ep [Epidemiology]
+ Female
+ *Fructose/ae [Adverse Effects]
+ Humans
+ Kidney Transplantation/ae [Adverse Effects]
+ *Kidney Transplantation
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Time Factors
+ Treatment Outcome
+Abstract
+ BACKGROUND: The concepts that obesity is merely a consequence of overeating, and that metabolic health then reflects obesity, may be insufficient and potentially flawed. The role of fructose intake and metabolic endotoxemia has gained attention recently, but data in kidney transplantation are lacking. This study evaluated the risk factors for metabolic syndrome (MS), its components, and other associated markers in kidney transplant recipients (KTRs), focusing particularly on fructose intake and systemic endotoxemia.
+
+ METHODS: This cross-sectional observational study enrolled 128 KTRs longer than 1 year posttransplantation. Clinical, biochemical, anthropometric, and questionnaire assessments were undertaken.
+
+ RESULTS: Obesity (body mass index, >=30 kg/m) and MS (International Diabetes Federation Definition) were found in 36.7% and 50% of KTRs, respectively. Both increased fructose intake (P = 0.01) and endotoxin level (P = 0.02) were independently associated with MS; and higher fructose intake was independently associated with obesity (P < 0.001). Specifically, increased fructose intake was associated with the central obesity (P = 0.01) and hyperglycemia (P < 0.001) criteria of MS, whereas higher endotoxin level was associated with the hypertriglyceridemia (P = 0.003) and low HDL cholesterol concentration (P = 0.002) criteria of MS. Neither saturated fat nor total caloric intakes were independently associated with obesity and MS; and neither obesity nor central obesity were independently associated with the dyslipidemia and hyperglycemia criteria of MS. Principal component analysis demonstrated relationships between higher levels of endotoxin, soluble endothelial selectin, triglycerides, and insulin resistance (r > 0.6), as well as relationships between increased fructose intake, inflammation, and blood glucose (r > 0.6).
+
+ CONCLUSIONS: Dietary modifications through decreasing fructose intake and addressing systemic endotoxemia are plausible targets for improving metabolic health of KTRs.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Sugars). 0 (Endotoxins). 0 (Lipids). 30237-26-4 (Fructose).
+Publication Type
+ Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fTP.0000000000002424
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chan&issn=0041-1337&title=Transplantation&atitle=Obesity+and+Metabolic+Syndrome+in+Kidney+Transplantation%3A+The+Role+of+Dietary+Fructose+and+Systemic+Endotoxemia.&volume=103&issue=1&spage=191&epage=201&date=2019&doi=10.1097%2FTP.0000000000002424&pmid=30130326&sid=OVID:medline
+
+<1906>
+Unique Identifier
+ 30129293
+Title
+ Decreased serum level of nitric oxide in children with excessive body weight.
+Source
+ Advances in Clinical & Experimental Medicine. 28(4):439-446, 2019 Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Czumaj A; Sledzinska M; Brzezinski M; Szlagatys-Sidorkiewicz A; Slominska E; Sledzinski T
+Authors Full Name
+ Czumaj, Aleksandra; Sledzinska, Marta; Brzezinski, Michal; Szlagatys-Sidorkiewicz, Agnieszka; Slominska, Ewa; Sledzinski, Tomasz.
+Institution
+ Czumaj, Aleksandra. Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland.
+ Sledzinska, Marta. Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, Medical University of Gdansk, Poland.
+ Brzezinski, Michal. Department of Public Health and Social Medicine, Faculty of Health Sciences, Medical University of Gdansk, Poland.
+ Szlagatys-Sidorkiewicz, Agnieszka. Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, Medical University of Gdansk, Poland.
+ Slominska, Ewa. Department of Biochemistry, Faculty of Medicine, Medical University of Gdansk, Poland.
+ Sledzinski, Tomasz. Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Poland.
+MeSH Subject Headings
+ Adolescent
+ *Arginine/aa [Analogs & Derivatives]
+ Arginine/bl [Blood]
+ Biomarkers/bl [Blood]
+ *Body Weight/ph [Physiology]
+ Cardiovascular Diseases
+ Case-Control Studies
+ Child
+ Child, Preschool
+ Female
+ Humans
+ Male
+ *Nitric Oxide/bl [Blood]
+ Nitric Oxide/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+Keyword Heading
+ asymmetric dimethylarginine
+ cardiovascular risk
+ children
+ nitric oxide
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Nitric oxide (NO) is an important mediator involved in vascular homeostasis. Changes in NO level are considered to be associated with obesity and its clinical consequences. Previous studies on NO levels in obese children provided inconclusive results, so this issue requires clarification.
+
+ OBJECTIVES: One of the main goals of this study was to assess whether childhood excessive body weight (EBW) is associated with changes in serum NO level and whether features like age and gender are linked to NO levels in selected groups.
+
+ MATERIAL AND METHODS: In the present study, the serum NO levels were compared in 43 children with EBW and 37 ageand gender-matched children with normal weight. Moreover, in both groups, body measurements and various clinical parameters, including the serum concentrations of arginine (Arg), a precursor of NO, were determined.
+
+ RESULTS: The mean serum NO level in EBW group (8.7 +/-3.1 mumol/L) was significantly lower than in normal weight group (22.2 +/-11.5 mumol/L). However, the serum Arg concentrations were higher in EBW children than in controls. Serum asymmetric dimethylarginine (ADMA) levels were higher in EBW group and inversely correlated with serum NO. The EBW female subgroup was characterized by slightly lower level of NO than the EBW male subgroup. There were no significant changes in serum NO level among different age subgroups in both groups.
+
+ CONCLUSIONS: Our results revealed that EBW in children is associated with significantly decreased level of serum NO. The decreased serum NO level in EBW children is not a result of depleted Arg in the blood. Asymmetric dimethylarginine may at least partially contribute to decreased NO levels in children with EBW. A decreased level of NO could be a potential early marker of the risk of cardiovascular disorders developing in children with EBW.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (dimethylarginine). 31C4KY9ESH (Nitric Oxide). 94ZLA3W45F (Arginine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.17219%2facem%2f77982
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Czumaj&issn=1899-5276&title=Advances+in+Clinical+%26+Experimental+Medicine&atitle=Decreased+serum+level+of+nitric+oxide+in+children+with+excessive+body+weight.&volume=28&issue=4&spage=439&epage=446&date=2019&doi=10.17219%2Facem%2F77982&pmid=30129293&sid=OVID:medline
+
+<1907>
+Unique Identifier
+ 30078743
+Title
+ Association of acylation stimulating protein and adiponectin with metabolic risk marker in North Indian obese women.
+Source
+ Diabetes & Metabolic Syndrome. 13(5):2987-2990, 2019 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mishra S; Gupta V; Mishra S; Kulshrestha H; Kumar S; Gupta V; Sachan R; Mahdi AA
+Authors Full Name
+ Mishra, Supriya; Gupta, Vani; Mishra, Sameeksha; Kulshrestha, Himani; Kumar, Sandeep; Gupta, Vandana; Sachan, Rekha; Mahdi, Abbas Ali.
+Institution
+ Mishra, Supriya. Department of Physiology, King George Medical University, Lucknow, India.
+ Gupta, Vani. Department of Physiology, King George Medical University, Lucknow, India. Electronic address: vaniphysiology@gmail.com.
+ Mishra, Sameeksha. Department of Physiology, King George Medical University, Lucknow, India.
+ Kulshrestha, Himani. Department of Physiology, King George Medical University, Lucknow, India.
+ Kumar, Sandeep. Department of Clinical Immunology, SGPGIMS, Lucknow, India.
+ Gupta, Vandana. Uttar Pradesh University of Medical Science, Saifai Etawah, India.
+ Sachan, Rekha. Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, India.
+ Mahdi, Abbas Ali. Department of Biochemistry, King George Medical University, Lucknow, India.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adult
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ *Complement C3a/an [Analysis]
+ Female
+ Follow-Up Studies
+ Humans
+ *Insulin Resistance
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/et [Etiology]
+ Middle Aged
+ *Obesity/co [Complications]
+ Prognosis
+ Risk Factors
+Keyword Heading
+ Acylation stimulating protein
+ Adiponectin
+ Metabolic syndrome
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Plasma concentrations of Acylation stimulating protein (ASP) and adiponectin are associated with body weight and energy homeostasis. The purpose of this study is to describe the potential role of acylation stimulating protein and adiponectin with metabolic risk marker in North Indian obese women.
+
+ METHODS: This is a case control study. Total 520 women were recruited for the study n=260 women with obesity (BMI>30) study group and n=260 women without obesity (BMI<25) control group. Serum ASP and adiponectin level were determined by enzyme linked immunosorbent assay.
+
+ RESULTS: Result indicated that WC, BP, lipid profile, FPG, FPI, IR (HOMA-IR), ASP were significantly higher but adiponectin and HDL were significantly lower in women with obesity than in women without obesity. Furthermore ASP was significantly positive correlated with WC, FPG, TG, VLDL, FPI and IR, whereas the correlation of adiponectin was significantly negative correlated with WC, FPG, TG, IR, ASP and significantly positive correlated with HDL in women with obesity.
+
+ CONCLUSION: The study shows that high level of ASP and low level of Adiponectin could be a potential marker of women with obesity among metabolic syndrome. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (complement C3a, des-Arg-(77)-). 80295-42-7 (Complement C3a).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.07.017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mishra&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+of+acylation+stimulating+protein+and+adiponectin+with+metabolic+risk+marker+in+North+Indian+obese+women.&volume=13&issue=5&spage=2987&epage=2990&date=2019&doi=10.1016%2Fj.dsx.2018.07.017&pmid=30078743&sid=OVID:medline
+
+<1908>
+Unique Identifier
+ 30072112
+Title
+ Diet-induced weight loss alone or combined with exercise in overweight or obese people with knee osteoarthritis: A systematic review and meta-analysis.
+Source
+ Seminars in Arthritis & Rheumatism. 48(5):765-777, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hall M; Castelein B; Wittoek R; Calders P; Van Ginckel A
+Authors Full Name
+ Hall, Michelle; Castelein, Birgit; Wittoek, Ruth; Calders, Patrick; Van Ginckel, Ans.
+Institution
+ Hall, Michelle. Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, University of Melbourne, Victoria, Australia.
+ Castelein, Birgit. Department of Rehabilitation Sciences, Ghent University Hospital Campus, Corneel Heymanslaan 10, Building 3B3, 9000 Ghent, Belgium.
+ Wittoek, Ruth. Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.
+ Calders, Patrick. Department of Rehabilitation Sciences, Ghent University Hospital Campus, Corneel Heymanslaan 10, Building 3B3, 9000 Ghent, Belgium.
+ Van Ginckel, Ans. Department of Rehabilitation Sciences, Ghent University Hospital Campus, Corneel Heymanslaan 10, Building 3B3, 9000 Ghent, Belgium. Electronic address: Ans.VanGinckel@UGent.be.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Diet, Reducing
+ *Exercise
+ Humans
+ Interleukin-6/bl [Blood]
+ *Obesity/co [Complications]
+ Osteoarthritis, Knee/co [Complications]
+ *Osteoarthritis, Knee/th [Therapy]
+ Pain Management/mt [Methods]
+ Randomized Controlled Trials as Topic
+ Weight Loss/ph [Physiology]
+Keyword Heading
+ Cytokines
+ Osteoarthritis
+ Patient reported outcomes
+ Treatment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: The purposes were to (i) determine the effect of diet-only treatments and combined diet and exercise treatments on pain and physical function and (ii) explore the effect of these treatments on inflammatory biomarkers in overweight and obese adults with knee osteoarthritis.
+
+ METHODS: Five electronic databases were searched until March 2017. Randomised controlled trials investigating the effect of non-surgical non-pharmacological weight loss treatment, with or without exercise, on self-reported pain and/or physical function and/or inflammatory biomarkers were selected. Two review authors independently extracted data and assessed risk of bias for each study. Standardised mean differences (SMD) of outcomes were pooled as appropriate, using a random effects approach.
+
+ RESULTS: 2676 articles were identified, 19 met review criteria and 9 met criteria for meta-analyses. Diet-only treatments did not reduce pain (SMD -0.13; 95% confidence interval, CI: -0.37, 0.10; I2=49%) while a combination of diet and exercise treatments did reduce pain moderately (SMD -0.37; 95%CI: -0.69, -0.04; I2=54%). Physical function improved moderately with diet treatments (SMD -0.30; 95%CI: -0.52, -0.08; I2=47%) and combined diet and exercise treatments (SMD -0.32; 95%CI: -0.56, -0.08; I2=24%). Of the inflammatory markers assessed, only IL-6 reduced with diet-only treatments (SMD -0.23; 95%CI: -0.45, -0.02; I2=0%).
+
+ CONCLUSION: Overall, moderate pain-relief is achievable with a combination of diet and exercise, but potentially not with diet-only treatments. Findings support that either diet-only treatments or combined diet and exercise treatments moderately improve physical function. Overall, treatment effects on inflammatory biomarkers are questionable. Copyright © 2018 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.semarthrit.2018.06.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hall&issn=0049-0172&title=Seminars+in+Arthritis+%26+Rheumatism&atitle=Diet-induced+weight+loss+alone+or+combined+with+exercise+in+overweight+or+obese+people+with+knee+osteoarthritis%3A+A+systematic+review+and+meta-analysis.&volume=48&issue=5&spage=765&epage=777&date=2019&doi=10.1016%2Fj.semarthrit.2018.06.005&pmid=30072112&sid=OVID:medline
+
+<1909>
+Unique Identifier
+ 30069718
+Title
+ Inhibition of adiposity and related metabolic disturbances by polyphenol-rich extract of Boswellia serrata gum through alteration of adipo/cytokine profiles.
+Source
+ Inflammopharmacology. 27(3):549-559, 2019 Jun.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gomaa AA; Farghaly HSM; El-Sers DA; Farrag MM; Al-Zokeim NI
+Authors Full Name
+ Gomaa, Adel A; Farghaly, Hanan S M; El-Sers, Dalia A; Farrag, Magda M; Al-Zokeim, Nahla I.
+Institution
+ Gomaa, Adel A. Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt. a.gomma@aun.edu.eg.
+ Farghaly, Hanan S M. Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.
+ El-Sers, Dalia A. Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
+ Farrag, Magda M. Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.
+ Al-Zokeim, Nahla I. Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.
+MeSH Subject Headings
+ *Adipokines/me [Metabolism]
+ Adiponectin/me [Metabolism]
+ Adipose Tissue/de [Drug Effects]
+ Adipose Tissue/me [Metabolism]
+ *Adiposity/de [Drug Effects]
+ Animals
+ Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers/me [Metabolism]
+ Body Weight/de [Drug Effects]
+ *Boswellia/ch [Chemistry]
+ *Cytokines/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Eating/de [Drug Effects]
+ Hyperlipidemias/dt [Drug Therapy]
+ Hyperlipidemias/me [Metabolism]
+ Insulin Resistance/ph [Physiology]
+ Lipase/me [Metabolism]
+ Male
+ Mice
+ Obesity/dt [Drug Therapy]
+ Obesity/me [Metabolism]
+ Orlistat/pd [Pharmacology]
+ *Plant Extracts/pd [Pharmacology]
+ *Polyphenols/pd [Pharmacology]
+ Rats
+ Rats, Wistar
+ *Resins, Plant/pd [Pharmacology]
+Keyword Heading
+ Body weight
+ Boswellia serrata extract
+ Cytokines
+ Histopathology
+ Insulin resistance
+ Lipid profile
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The role of proinflammatory cytokines in adiposity is well established. The anti-inflammatory and antihyperglycemia effects of Boswellia serrata (B. Serrata) gum have been demonstrated by many investigators. The present study aimed to investigate the anti-obesity potential of B. serrata extract.
+
+ METHODS: The effects of B. serrata extract on lipase activity and acute food intake were investigated. The present study aimed to investigate the anti-obesity potential of B. serrata extract. The effects on lipase activity and acute food intake were investigated. Body weight changes, biochemical and histopathological markers were demonstrated in rats fed a high-fat diet.
+
+ RESULTS: Boswellia serrata extract inhibited alterations in pancreatic lipase activity, but orlistat was more efficacious. B. serrata and ephidrene, but not orlistat, significantly suppressed cumulative food intake in mice. In obese rats, B. serrata or orlistat significantly decreased weight gain and weight of visceral white adipose tissue. B. serrata-treated animals exhibited a significant reduction in serum glucose, TC, TG, LDL-C, FFA, IL-1beta, TNF-alpha, insulin and leptin levels of obese rat groups while HDL-C and adiponectin levels were significantly increased by orlistat or B. serrata extract. Histopathological examination of the liver revealed that B. serrata was more effective than orlistat in alleviating steatosis and adipocyte hypertrophy shown in obese control rats.
+
+ CONCLUSIONS: Boswellia serrata is as effective as orlistat in preventing obesity, hyperlipidemia, steatosis and insulin resistance. These actions may be mediated by suppression of food intake and decrease levels of TNF-alpha, IL-1beta and leptin resistance along with increasing adiponectin.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Adiponectin). 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Cytokines). 0 (Plant Extracts). 0 (Polyphenols). 0 (Resins, Plant). 95M8R751W8 (Orlistat). EC 3-1-1-3 (Lipase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs10787-018-0519-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gomaa&issn=0925-4692&title=Inflammopharmacology&atitle=Inhibition+of+adiposity+and+related+metabolic+disturbances+by+polyphenol-rich+extract+of+Boswellia+serrata+gum+through+alteration+of+adipo%2Fcytokine+profiles.&volume=27&issue=3&spage=549&epage=559&date=2019&doi=10.1007%2Fs10787-018-0519-4&pmid=30069718&sid=OVID:medline
+
+<1910>
+Unique Identifier
+ 30057069
+Title
+ Lifestyle and diabetes among Muslim population of Manipur.
+Source
+ Diabetes & Metabolic Syndrome. 13(5):3043-3046, 2019 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nilupher; Dhall M; Kapoor S
+Authors Full Name
+ Nilupher; Dhall, Meenal; Kapoor, Satwanti.
+Institution
+ Nilupher. Department of Anthropology, University of Delhi, Delhi, 110007, India. Electronic address: nilupher12@gmail.com.
+ Dhall, Meenal. Department of Anthropology, University of Delhi, Delhi, 110007, India. Electronic address: say2meenal@gmail.com.
+ Kapoor, Satwanti. Department of Anthropology, University of Delhi, Delhi, 110007, India. Electronic address: satwanti@yahoo.com.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers/an [Analysis]
+ Cross-Sectional Studies
+ *Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Humans
+ India/ep [Epidemiology]
+ Islam
+ *Life Style
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ Sedentary Behavior
+ Young Adult
+Keyword Heading
+ Adiposity
+ Health
+ Imphal
+ Metabolic
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: This study aims to find out the association of lifestyle with adiposity markers among the patients with diabetes.
+
+ MATERIALS AND METHODS: 200 diabetic participants of both sexes were enrolled in the present study. Age group of the participants ranged from 20 years to 45 years. A cross sectional study was conducted for the present study. Data was collected from Imphal East district and Thoubal district of Manipur.
+
+ OBSERVATIONS: The study reported maximum percentage of overweight BMI among diabetic females as compared to diabetic males. Spending long hours at work place was positively associated with body mass index among diabetic participants.
+
+ CONCLUSIONS: This study informs the need of physical activity for those individuals who were physically inactive and had diabetes, as increasing BMI may lead to other non-communicable diseases. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.07.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dhall&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Lifestyle+and+diabetes+among+Muslim+population+of+Manipur.&volume=13&issue=5&spage=3043&epage=3046&date=2019&doi=10.1016%2Fj.dsx.2018.07.006&pmid=30057069&sid=OVID:medline
+
+<1911>
+Unique Identifier
+ 30032988
+Title
+ Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract.
+Source
+ Nutrition Research. 70:50-59, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fang X; Chung J; Olsen E; Snider I; Earls RH; Jeon J; Park HJ; Lee JK
+Authors Full Name
+ Fang, Xi; Chung, Jaegwon; Olsen, Erik; Snider, Isabelle; Earls, Rachael H; Jeon, Julie; Park, Hea Jin; Lee, Jae-Kyung.
+Institution
+ Fang, Xi. Department of Foods and Nutrition, College of Family and Consumer Sciences, University of Georgia, Athens, GA 30602. Electronic address: xi.fang25@uga.edu.
+ Chung, Jaegwon. Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602. Electronic address: jaechung@uga.edu.
+ Olsen, Erik. Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602. Electronic address: erik.olsen25@uga.edu.
+ Snider, Isabelle. Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602. Electronic address: ivs36369@uga.edu.
+ Earls, Rachael H. Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602. Electronic address: rachaelhart1226@gmail.com.
+ Jeon, Julie. Department of Foods and Nutrition, College of Family and Consumer Sciences, University of Georgia, Athens, GA 30602. Electronic address: Julie.Jeon@uga.edu.
+ Park, Hea Jin. Department of Foods and Nutrition, College of Family and Consumer Sciences, University of Georgia, Athens, GA 30602. Electronic address: hjpark@uga.edu.
+ Lee, Jae-Kyung. Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602. Electronic address: jamlee@uga.edu.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ *Camellia sinensis
+ *Diet, High-Fat
+ Dietary Fats/ae [Adverse Effects]
+ Glucose Intolerance/et [Etiology]
+ Glucose Intolerance/me [Metabolism]
+ Glucose Intolerance/pc [Prevention & Control]
+ Inflammation/et [Etiology]
+ *Inflammation/me [Metabolism]
+ Inflammation/pc [Prevention & Control]
+ *Insulin/me [Metabolism]
+ *Insulin Resistance
+ Liver/me [Metabolism]
+ Male
+ Mice, Inbred C57BL
+ Mice, Knockout
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Phenotype
+ Phytotherapy
+ Plant Extracts/pd [Pharmacology]
+ Plant Extracts/tu [Therapeutic Use]
+ *RGS Proteins/me [Metabolism]
+ Signal Transduction
+ Tea
+Keyword Heading
+ Antioxidants
+ Glucose tolerance
+ Obesity
+ Phytochemicals
+ RGS
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The interaction between insulin resistance and inflammation plays a central role in the development of chronic diseases, although the mechanism is not fully understood. We previously demonstrated that regulator of G-protein signaling-10 (RGS10) protein is a negative modulator of the inflammatory response in macrophages and microglia. Because inflammation is a critical component in the development of high fat diet-induced insulin resistance, in this study we investigated whether RGS10 is involved in the diet-dependent regulation of glucose tolerance and insulin sensitivity. We hypothesized that the absence of RGS10 would exaggerate high-fat diet (HFD)-induced insulin resistance and inflammation response. Our results showed that RGS10 knockout (KO) mice fed a HFD gained significantly more weight and developed severe insulin resistance compared to wild-type (WT) mice fed HFD. Furthermore, compared to WT HFD-fed mice, KO mice fed the HFD displayed inflammatory phenotypes such as decreased adipose tissue expression of the anti-inflammatory M2 markers YM1 and Fizz1 and increased expression of the proinflammatory M1 cytokine interleukin 6 in adipose and CD11b, CD68 and interleukin 1beta in liver tissues. The impact of RGS10 deficiency on the exaggeration of HFD-induced insulin resistance and inflammation was ameliorated by oral consumption of green tea extract. Our results demonstrate that RGS10 is an important part of a protective mechanism involved in in regulating metabolic homeostasis by reducing inflammatory responses, which could potentially lead to an innovative new approach targeting inflammation and insulin resistance. Copyright © 2018 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fats). 0 (Insulin). 0 (Plant Extracts). 0 (RGS Proteins). 0 (Rgs10 protein, mouse). 0 (Tea).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.nutres.2018.06.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fang&issn=0271-5317&title=Nutrition+Research&atitle=Depletion+of+regulator-of-G-protein+signaling-10+in+mice+exaggerates+high-fat+diet-induced+insulin+resistance+and+inflammation%2C+and+this+effect+is+mitigated+by+dietary+green+tea+extract.&volume=70&issue=&spage=50&epage=59&date=2019&doi=10.1016%2Fj.nutres.2018.06.004&pmid=30032988&sid=OVID:medline
+
+<1912>
+Unique Identifier
+ 30032465
+Title
+ Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians.
+Source
+ Sleep & Breathing. 23(1):171-178, 2019 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bhatt SP; Guleria R; Vikram NK; Gupta AK
+Author NameID
+ Guleria, Randeep; ORCID: http://orcid.org/0000-0002-6258-2160
+Authors Full Name
+ Bhatt, Surya Prakash; Guleria, Randeep; Vikram, Naval K; Gupta, A K.
+Institution
+ Bhatt, Surya Prakash. Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, 110029, India.
+ Guleria, Randeep. Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, 110029, India. randeepg@hotmail.com.
+ Vikram, Naval K. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
+ Gupta, A K. Department of Radiology, All India Institute of Medical Sciences, New Delhi, India.
+MeSH Subject Headings
+ Adult
+ *Asian People
+ Biomarkers
+ Body Mass Index
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/et [Etiology]
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ *Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Obesity/co [Complications]
+ Risk Factors
+ Severity of Illness Index
+ Sleep Apnea, Obstructive/bl [Blood]
+ *Sleep Apnea, Obstructive/co [Complications]
+ Sleep Apnea, Obstructive/pp [Physiopathology]
+Keyword Heading
+ Apnea hypopnea index
+ Insulin resistance
+ Metabolic syndrome
+ Non-alcoholic fatty liver disease
+ Obstructive sleep apnea
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obstructive sleep apnea (OSA) has been estimated to affect 4-11% of the population and causes systemic inflammation which leads to metabolic syndrome (MS). Non-alcoholic fatty liver disease (NAFLD) is also associated with MS whether NAFLD is an additional risk factor for the systemic inflammation that occurs in OSA is unclear.
+
+ OBJECTIVE: In this study, we aimed to analyze the association of OSA and NAFLD with MS and systemic inflammation in Asian Indians.
+
+ METHODS: Total 240 (132 males and 108 females) overweight/obese subjects [body mass index (BMI > 23 kg/m2)] were recruited; of these, 124 subjects had OSA with NAFLD, 47 had OSA without NAFLD, 44 did not have OSA but had NAFLD and 25 had neither OSA nor without NAFLD. Severity of NAFLD was based on abdomen ultrasound and of OSA on overnight polysomnography. Clinical examinations, anthropometry, body composition, metabolic parameters, and inflammatory biomarkers were recorded.
+
+ RESULTS: Serum levels of leptin, macrophage migration inhibitory factor (MIF), interleukin-6 (IL-6), high sensitive C-reactive protein (Hs-CRP), and tumor necrosis factor alpha (TNF-alpha) were significantly higher, and adiponectin levels were significantly lower in OSA with NAFLD subjects. Prevalence of MS was significantly increased in OSA and NAFLD subjects (p = 0.001). There was a strong association and correlation between leptin, IL-6, Hs-CRP, MIF, and TNF-alpha in OSA and NAFLD subjects. Multivariate logistic regression showed that OSA was positively associated with the NAFLD [odds ratio (OR), (95% confidence interval (CL) 3.12 (2.58-7.72), (P = 0.002)].
+
+ CONCLUSION: NAFLD is an additional risk factor in OSA subject which contributes to systemic inflammation in Asian Indians.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11325-018-1678-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bhatt&issn=1520-9512&title=Sleep+%26+Breathing&atitle=Non-alcoholic+fatty+liver+disease+is+an+independent+risk+factor+for+inflammation+in+obstructive+sleep+apnea+syndrome+in+obese+Asian+Indians.&volume=23&issue=1&spage=171&epage=178&date=2019&doi=10.1007%2Fs11325-018-1678-7&pmid=30032465&sid=OVID:medline
+
+<1913>
+Unique Identifier
+ 30030159
+Title
+ DPP4 activity is related to body weight and central fat in postmenopausal women.
+Source
+ Diabetes & Metabolic Syndrome. 13(5):3031-3034, 2019 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Siciliano PO; Godoy-Matos AF; Braga LDDC; Denise Pires Carvalho J; Correa JODA
+Authors Full Name
+ Siciliano, Priscila de Oliveira; Godoy-Matos, Amelio F; Braga, Leticia Dinis da C; Denise Pires Carvalho, Jose; Correa, Jose Otavio do Amaral.
+Institution
+ Siciliano, Priscila de Oliveira. Metabolism Unit, Instituto Estadual de Diabetes e Endocrinologia(IEDE), Rio de Janeiro, RJ, Brazil. Electronic address: prisiciliano@yahoo.com.br.
+ Godoy-Matos, Amelio F. Metabolism Unit, Instituto Estadual de Diabetes e Endocrinologia(IEDE), Rio de Janeiro, RJ, Brazil.
+ Braga, Leticia Dinis da C. Metabolism Unit, Instituto Estadual de Diabetes e Endocrinologia(IEDE), Rio de Janeiro, RJ, Brazil.
+ Denise Pires Carvalho, Jose. Endocrine Physiology Laboratory, Biophysics Institute of Carlos Chagas Filho, Universidade Federal do Rio de Janeiro(UFRJ), Rio de Janeiro, RJ, Brazil.
+ Correa, Jose Otavio do Amaral. Director of Pharmacy Faculty, Universidade Federal de Juiz de Fora(UFJF), Juiz de Fora, MG, Brazil.
+MeSH Subject Headings
+ *Adipose Tissue/pp [Physiopathology]
+ Anthropometry
+ *Biomarkers/bl [Blood]
+ *Body Fat Distribution
+ *Body Weight
+ Brazil/ep [Epidemiology]
+ Case-Control Studies
+ *Dipeptidyl Peptidase 4/bl [Blood]
+ Female
+ Follow-Up Studies
+ Humans
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Postmenopause
+ Premenopause
+ Prognosis
+Keyword Heading
+ Adipokine
+ Body weight
+ Central fat
+ Dipeptidyl peptidase-4
+ Postmenopause
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Dipeptidyl peptidase-4 (DPP4) is a new adipokine increased in central obesity and related to insulin resistance (IR). Postmenopausal (PM) state may be associated with increase in body weight and central fat distribution. We hypothesize that DPP4 is increased in PM women.
+
+ MATERIALS AND METHODS: Twenty-two non-obese PM and 22 non-obese premenopausal women (PreM), were evaluated. DPP4 activity, lipid profile, HbA1c, FSH, estradiol and sex hormone-binding globulin (SHBG) were measured; an oral glucose tolerance test (OGTT) was performed and IR calculated. Body composition was assessed by dual X-ray absorptiometry (DXA). Correlations between DPP4 and the anthropometric and metabolic variables and body fat distribution were studied.
+
+ RESULTS: DPP4 activity was not different between the two groups (PM 5309+/-650 vs PreM 5387+/-704 RLU; p=0,70). In the PM group there was a significant correlation between DPP4 and body weight (r=0,498; p=0,03; n=22) and trunk fat (r=0,477; p=0,03; n=21). There was also a trend for correlation with android (r=0,418; p=0,06; n=21) and total fat (r=0,409; p=0,06; n=21). When stratified by BMI, DPP4 was significantly higher in PM women with BMI >=25kg/m2 (p=0,02).
+
+ CONCLUSION: DPP4 was not increased in PM but is associated with body weight and body fat centralization. Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). EC 3-4-14-5 (DPP4 protein, human). EC 3-4-14-5 (Dipeptidyl Peptidase 4).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.07.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Siciliano&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=DPP4+activity+is+related+to+body+weight+and+central+fat+in+postmenopausal+women.&volume=13&issue=5&spage=3031&epage=3034&date=2019&doi=10.1016%2Fj.dsx.2018.07.008&pmid=30030159&sid=OVID:medline
+
+<1914>
+Unique Identifier
+ 30026588
+Title
+ Adult weight change in relation to visceral fat and liver fat at middle age: The Netherlands epidemiology of obesity study.
+Source
+ International Journal of Obesity. 43(4):790-799, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Verkouter I; Noordam R; de Roos A; Lamb HJ; Rosendaal FR; van Heemst D; de Mutsert R
+Author NameID
+ Verkouter, Inge; ORCID: http://orcid.org/0000-0003-3374-7840
+Authors Full Name
+ Verkouter, Inge; Noordam, Raymond; de Roos, Albert; Lamb, Hildo J; Rosendaal, Frits R; van Heemst, Diana; de Mutsert, Renee.
+Institution
+ Verkouter, Inge. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
+ Verkouter, Inge. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
+ Noordam, Raymond. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
+ de Roos, Albert. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
+ Lamb, Hildo J. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
+ Rosendaal, Frits R. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
+ van Heemst, Diana. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
+ de Mutsert, Renee. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. r.de_mutsert@lumc.nl.
+MeSH Subject Headings
+ *Adiposity/ph [Physiology]
+ Biomarkers
+ Body Mass Index
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ *Fatty Liver/ep [Epidemiology]
+ Fatty Liver/pp [Physiopathology]
+ Female
+ Health Surveys
+ Humans
+ Insulin Resistance/ph [Physiology]
+ *Intra-Abdominal Fat/ph [Physiology]
+ Male
+ *Metabolic Diseases/ep [Epidemiology]
+ Metabolic Diseases/et [Etiology]
+ Middle Aged
+ *Neoplasms/ep [Epidemiology]
+ Neoplasms/et [Etiology]
+ Netherlands/ep [Epidemiology]
+ Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Population Surveillance
+ Weight Gain
+Abstract
+ OBJECTIVE: We aimed to investigate the associations between weight change during adulthood and the amount of abdominal subcutaneous fat, visceral fat, and liver fat at middle age.
+
+ METHODS: The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort of 6671 middle-aged men and women. We calculated the percentage of weight change during adulthood based on body weight at middle age and recalled body weight at age 20. Abdominal subcutaneous and visceral adipose tissue were assessed by magnetic resonance imaging (MRI), in addition to hepatic triglyceride content by 1H-MR spectroscopy in a random subgroup (maximum of n = 2580). With multivariable linear regression analysis, we examined the associations between categories of adult weight change, body mass index (BMI) at age 20 and measures of abdominal adiposity at middle age, adjusted for age, sex, ethnicity, lifestyle factors, menopausal status, parity, use of medication and total body fat at middle age.
+
+ RESULTS: In 2399 participants (54% women), individuals who gained more than 50% of body weight during adulthood had 1.96 (95% CI: 1.64; 2.33) times more visceral adipose tissue at middle age and 2.39 (95% CI: 1.70, 3.36) times more hepatic triglyceride content than weight maintainers (weight change between -5% and 5%). Associations with abdominal subcutaneous adipose tissue were weaker: participants who gained more than 50% of their body weight had 1.54 (95% CI: 1.38, 1.72) times more abdominal subcutaneous adipose tissue compared with weight maintainers.
+
+ CONCLUSIONS: In this population-based study, adult weight gain was associated with relatively more visceral adipose tissue and hepatic triglyceride content at middle age than abdominal subcutaneous adipose tissue. Overall, our study suggests that weight maintenance during adulthood plays an important role in limiting excess visceral adipose tissue and hepatic triglyceride content at middle age.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0163-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Verkouter&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Adult+weight+change+in+relation+to+visceral+fat+and+liver+fat+at+middle+age%3A+The+Netherlands+epidemiology+of+obesity+study.&volume=43&issue=4&spage=790&epage=799&date=2019&doi=10.1038%2Fs41366-018-0163-5&pmid=30026588&sid=OVID:medline
+
+<1915>
+Unique Identifier
+ 29990442
+Title
+ Pentraxin 3 increases in adult overweight and obese men after weight loss by dietary modification with exercise training.
+Source
+ Applied Physiology, Nutrition, & Metabolism = Physiologie Appliquee, Nutrition et Metabolisme. 44(2):111-117, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zempo-Miyaki A; Kumagai H; Yoshikawa T; Myoenzono K; So R; Otsuki T; Tanaka K; Maeda S
+Authors Full Name
+ Zempo-Miyaki, Asako; Kumagai, Hiroshi; Yoshikawa, Toru; Myoenzono, Kanae; So, Rina; Otsuki, Takeshi; Tanaka, Kiyoji; Maeda, Seiji.
+Institution
+ Zempo-Miyaki, Asako. a Faculty of Sport and Health Sciences, Ryutsu Keizai University, Ibaraki 301-8555, Japan.
+ Kumagai, Hiroshi. b Graduate School of Health and Sports Science, Juntendo University, Chiba 270-1695, Japan.
+ Kumagai, Hiroshi. c Japan Society for the Promotion of Sciences, Tokyo 102-0083, Japan.
+ Yoshikawa, Toru. c Japan Society for the Promotion of Sciences, Tokyo 102-0083, Japan.
+ Yoshikawa, Toru. d Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8577, Japan.
+ Myoenzono, Kanae. d Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8577, Japan.
+ So, Rina. e Research Center for Overwork-Related Disorders, National Institute of Occupational Safety and Health, Kawasaki, Kanagawa 214-8585, Japan.
+ Otsuki, Takeshi. a Faculty of Sport and Health Sciences, Ryutsu Keizai University, Ibaraki 301-8555, Japan.
+ Tanaka, Kiyoji. f Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8577, Japan.
+ Maeda, Seiji. f Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8577, Japan.
+MeSH Subject Headings
+ Ankle Brachial Index
+ Biomarkers/bl [Blood]
+ Blood Pressure
+ Body Mass Index
+ C-Reactive Protein/an [Analysis]
+ *C-Reactive Protein/me [Metabolism]
+ *Diet, Reducing
+ *Exercise
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ *Obesity/th [Therapy]
+ *Overweight/bl [Blood]
+ Overweight/dh [Diet Therapy]
+ *Overweight/th [Therapy]
+ Serum Amyloid P-Component/an [Analysis]
+ *Serum Amyloid P-Component/me [Metabolism]
+ Treatment Outcome
+ *Weight Loss
+Keyword Heading
+ PTX3
+ inflammation
+ obesity
+ obesite
+ perte de poids
+ weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The circulatory level of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, has been shown to be lower in obese individuals than in those with normal weight. However, reports on the effects of different weight-loss methods on PTX3 are limited. The present study aimed to investigate the effect of weight loss on circulating PTX3 levels in overweight and obese men and to examine the combined effect of dietary modification and exercise training on PTX3 levels. Forty-eight overweight and obese men were assigned to 2 groups: dietary modification (group D) or exercise training and dietary modification (group DE). Groups D and DE were composed of 27 and 21 participants, respectively. We observed a significant independent relationship between changes in PTX3 and body mass index (BMI) in all participants (beta = -0.617, p < 0.01). Subsequently, we compared the effects of the 2 weight-loss methods on plasma PTX3 in groups D and DE. The magnitude of the increase in plasma PTX3 levels was similar in the 2 groups. Interestingly, we observed that PTX3 levels in group DE increased significantly more than those in group D in subjects who achieved normal weight, based on BMI, after interventions. Our study suggested that weight reduction after lifestyle modification significantly increased PTX3 levels in overweight and obese men, and the addition of habitual exercise to dietary modification enhanced the magnitude of the increase in PTX3 levels in obese individuals achieving normal weight after weight loss.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Serum Amyloid P-Component). 148591-49-5 (PTX3 protein). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1139%2fapnm-2018-0214
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zempo-Miyaki&issn=1715-5312&title=Applied+Physiology%2C+Nutrition%2C+%26+Metabolism+%3D+Physiologie+Appliquee%2C+Nutrition+et+Metabolisme&atitle=Pentraxin+3+increases+in+adult+overweight+and+obese+men+after+weight+loss+by+dietary+modification+with+exercise+training.&volume=44&issue=2&spage=111&epage=117&date=2019&doi=10.1139%2Fapnm-2018-0214&pmid=29990442&sid=OVID:medline
+
+<1916>
+Unique Identifier
+ 29985729
+Title
+ Platelet reactivity in overweight and obese patients undergoing cardiac surgery.
+Source
+ Platelets. 30(5):608-614, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ranucci M; Aloisio T; Dedda UD; La Rovere MT; De Arroyabe BML; Baryshnikova E
+Authors Full Name
+ Ranucci, Marco; Aloisio, Tommaso; Dedda, Umberto Di; La Rovere, Maria Teresa; De Arroyabe, Blanca Martinez Lopez; Baryshnikova, Ekaterina.
+Institution
+ Ranucci, Marco. a Department of Cardiothoracic-Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.
+ Aloisio, Tommaso. a Department of Cardiothoracic-Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.
+ Dedda, Umberto Di. a Department of Cardiothoracic-Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.
+ La Rovere, Maria Teresa. b Department of Cardiology, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Montescano, Italy.
+ De Arroyabe, Blanca Martinez Lopez. c Cardiac Anesthesia Unit, Department of Emergency Medicine, University Hospital of Trieste, Trieste, Italy.
+ Baryshnikova, Ekaterina. a Department of Cardiothoracic-Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ Blood Coagulation
+ Blood Platelets/de [Drug Effects]
+ *Blood Platelets/me [Metabolism]
+ *Cardiac Surgical Procedures
+ Cohort Studies
+ Comorbidity
+ Female
+ Heart Diseases/bl [Blood]
+ Heart Diseases/co [Complications]
+ Heart Diseases/su [Surgery]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Overweight/bl [Blood]
+ Overweight/co [Complications]
+ Platelet Activation/de [Drug Effects]
+ *Platelet Activation
+ Platelet Aggregation/de [Drug Effects]
+ Platelet Aggregation Inhibitors/pd [Pharmacology]
+ Platelet Function Tests
+Keyword Heading
+ Cardiac surgery
+ electric impedance aggregometry
+ obesity
+ platelet function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Body mass index (BMI) and specifically overweight and obesity have been associated with an increased platelet reactivity in different series of patients. This information is derived by different laboratory platelet function tests (PFTs) like mean platelet volume (MPV), platelet microparticles, thromboxane B2 metabolites, and others. Point-of-care PFT, which are often used in cardiac surgery, are rarely addressed. The present study aims to verify platelet reactivity using multiple-electrode aggregometry (MEA) as a function of BMI in cardiac surgery patients. One-hundred ninety-eight cardiac surgery patients free from the effects of drugs acting on the P2Y12 receptor and undergoing cardiac surgery received MEA-PFT immediately before surgery. Platelet reactivity was compared between normal weight and overweight-obese subjects. There were 99 underweight/normal (BMI < 25), 60 overweight (BMI >= 25) and 39 obese (BMI >= 30) patients. Overweight-obese patients did not show higher platelet counts nor a clear platelet hyper-reactivity, when tested with MPV and MEA ADP test. At TRAPtest, the overweight/obese patients had a significantly (P = 0.011) higher platelet reactivity (median 118, interquartile range 106-136) than controls (median 112, interquartile range 101-123) and a higher rate of platelet hyper-reactivity (odds ratio 2.19, 95% confidence interval 1.15-4.16, P = 0.016) in a multivariable model. A minor association was found between the BMI and platelet reactivity at TRAPtest, with a higher degree of activity for increasing BMI. The BMI determines an increased thrombin-dependent platelet reactivity in cardiac surgery patients. Thrombin is extensively formed during cardiac surgery, and this may explain the lower postoperative bleeding observed in obese patients in previous studies.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Platelet Aggregation Inhibitors).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f09537104.2018.1492108
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ranucci&issn=0953-7104&title=Platelets&atitle=Platelet+reactivity+in+overweight+and+obese+patients+undergoing+cardiac+surgery.&volume=30&issue=5&spage=608&epage=614&date=2019&doi=10.1080%2F09537104.2018.1492108&pmid=29985729&sid=OVID:medline
+
+<1917>
+Unique Identifier
+ 29956214
+Title
+ Circulating insulin-like peptide 5 levels and its association with metabolic and hormonal parameters in women with polycystic ovary syndrome.
+Source
+ Journal of Endocrinological Investigation. 42(3):303-312, 2019 Mar.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bicer M; Alan M; Alarslan P; Guler A; Kocabas GU; Imamoglu C; Aksit M; Bozkaya G; Isil AM; Baloglu A; Aslanipoiur B; Calan M
+Authors Full Name
+ Bicer, M; Alan, M; Alarslan, P; Guler, A; Kocabas, G U; Imamoglu, C; Aksit, M; Bozkaya, G; Isil, A M; Baloglu, A; Aslanipoiur, B; Calan, Mehmet.
+Institution
+ Bicer, M. Department of Obstetrics and Gynecology, Medical Park Hospital, 35575, Izmir, Turkey.
+ Alan, M. Department of Obstetrics and Gynecology, Izmir Tepecik Training and Research Hospital, Tepecik, 35120, Izmir, Turkey.
+ Alarslan, P. Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey.
+ Guler, A. Department of Family Physician, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey.
+ Kocabas, G U. Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey.
+ Imamoglu, C. Department of Radiology, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey.
+ Aksit, M. Department of Biochemistry and Clinical Biochemistry, Izmir Tepecik Training and Research Hospital, Tepecik, 35120, Izmir, Turkey.
+ Bozkaya, G. Department of Biochemistry and Clinical Biochemistry, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey.
+ Isil, A M. Department of Family Physician, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey.
+ Baloglu, A. Department of Obstetrics and Gynecology, Private Gynecology Clinic, 35172, Izmir, Turkey.
+ Aslanipoiur, B. Department of Bioengineering, Faculty of Engineering, Ege University, Izmir, Turkey.
+ Calan, Mehmet. Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey. drmehmetcalan@gmail.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ *Carotid Intima-Media Thickness
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ *Hormones/me [Metabolism]
+ Humans
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ Male
+ Metabolic Diseases/bl [Blood]
+ *Metabolic Diseases/di [Diagnosis]
+ Metabolic Diseases/et [Etiology]
+ Middle Aged
+ Obesity/pp [Physiopathology]
+ Overweight
+ *Polycystic Ovary Syndrome/co [Complications]
+ Prognosis
+ Proteins
+ ROC Curve
+ Young Adult
+Keyword Heading
+ Body mass index
+ Carotid intima media thickness
+ Insulin resistance
+ Insulin-like peptide 5
+ Polycystic ovary syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Insulin-like peptide 5 (INSL5) is a gut peptide hormone that is a member of relaxin/insulin superfamily. Growing evidence implicates the crucial role of the peptide in some metabolisms including food intake, glucose homeostasis and reproductive system. Polycystic ovary syndrome (PCOS) is involved in both reproductive and metabolic issues. The aim of the study was determination of circulating levels of INSL5 alteration in women with PCOS and evaluation of the relationship between INSL5 and hormonal-metabolic parameters as well as carotid intima media thickness (cIMT).
+
+ METHODS: A total of 164 subjects were recruited in this cross-sectional study (82 women with PCOS and 82 age- and BMI-matched controls). Circulating INSL5 levels were assessed via ELISA method. High-resolution B-mode ultrasound was used to measure cIMT. The hormonal and metabolic parameters of the recruited subjects were determined.
+
+ RESULTS: Circulating INSL5 levels were significantly elevated in women with PCOS compared to controls (27.63 +/- 7.74 vs. 19.90 +/- 5.85 ng/ml, P < 0.001). The mean values of INSL5 were significantly higher in overweight subjects compared to lean weight subjects in both groups. The women with PCOS having insulin resistance have increased INSL5 compared to those of PCOS subjects without insulin resistance. INSL5 is associated with insulin resistance, BMI, luteinizing hormone and free androgen index. Multivariate logistic regression analyses revealed that the odds ratio for having PCOS in the highest tertile of INSL5 was higher than in the lowest tertile.
+
+ CONCLUSIONS: PCOS subjects exhibited an elevation in circulating INSL5 levels along with a link between INSL5 level induction and metabolic-hormonal parameters.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hormones). 0 (Insulin). 0 (Leydig insulin-like protein). 0 (Proteins).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs40618-018-0917-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bicer&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Circulating+insulin-like+peptide+5+levels+and+its+association+with+metabolic+and+hormonal+parameters+in+women+with+polycystic+ovary+syndrome.&volume=42&issue=3&spage=303&epage=312&date=2019&doi=10.1007%2Fs40618-018-0917-x&pmid=29956214&sid=OVID:medline
+
+<1918>
+Unique Identifier
+ 29948221
+Title
+ An integrated transcriptomic and epigenomic analysis identifies CD44 gene as a potential biomarker for weight loss within an energy-restricted program.
+Source
+ European Journal of Nutrition. 58(5):1971-1980, 2019 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Samblas M; Mansego ML; Zulet MA; Milagro FI; Martinez JA
+Author NameID
+ Samblas, Mirian; ORCID: http://orcid.org/0000-0003-0866-2300
+ Mansego, Maria Luisa; ORCID: http://orcid.org/0000-0001-8914-7890
+ Zulet, Maria Angeles; ORCID: http://orcid.org/0000-0002-3926-0892
+ Milagro, Fermin I; ORCID: http://orcid.org/0000-0002-3228-9916
+ Martinez, J Alfredo; ORCID: http://orcid.org/0000-0001-5218-6941
+Authors Full Name
+ Samblas, Mirian; Mansego, Maria Luisa; Zulet, Maria Angeles; Milagro, Fermin I; Martinez, J Alfredo.
+Institution
+ Samblas, Mirian. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Irunlarrea 1, 31008, Pamplona, Navarra, Spain.
+ Mansego, Maria Luisa. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Irunlarrea 1, 31008, Pamplona, Navarra, Spain.
+ Mansego, Maria Luisa. CIBERobn, CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Madrid, Spain.
+ Zulet, Maria Angeles. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Irunlarrea 1, 31008, Pamplona, Navarra, Spain.
+ Zulet, Maria Angeles. CIBERobn, CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Madrid, Spain.
+ Zulet, Maria Angeles. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+ Milagro, Fermin I. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Irunlarrea 1, 31008, Pamplona, Navarra, Spain. fmilagro@unav.es.
+ Milagro, Fermin I. CIBERobn, CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Madrid, Spain. fmilagro@unav.es.
+ Martinez, J Alfredo. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Irunlarrea 1, 31008, Pamplona, Navarra, Spain.
+ Martinez, J Alfredo. CIBERobn, CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Madrid, Spain.
+ Martinez, J Alfredo. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
+MeSH Subject Headings
+ Biomarkers
+ *Caloric Restriction/mt [Methods]
+ *Epigenomics/mt [Methods]
+ Female
+ Humans
+ *Hyaluronan Receptors/ge [Genetics]
+ Longitudinal Studies
+ Male
+ Middle Aged
+ *Obesity/dt [Drug Therapy]
+ Oligonucleotide Array Sequence Analysis
+ *Transcriptome/ge [Genetics]
+ *Weight Loss/ge [Genetics]
+ Weight Reduction Programs/mt [Methods]
+Keyword Heading
+ Metabolic syndrome
+ Methylation
+ Obesity
+ Weight loss
+ mRNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: The interindividual variable response to weight-loss treatments requires the search for new predictive biomarkers for improving the success of weight-loss programs. The aim of this study is to identify novel genes that distinguish individual responses to a weight-loss dietary treatment by using the integrative analysis of mRNA expression and DNA methylation arrays.
+
+ METHODS: Subjects from Metabolic Syndrome Reduction in Navarra (RESMENA) project were classified as low (LR) or high (HR) responders depending on their weight loss. Transcriptomic (n = 24) and epigenomic (n = 47) patterns were determined by array-based genome-wide technologies in human white blood cells at the baseline of the treatment period. CD44 expression was validated by qRT-PCR and methylation degree of CpGs of the gene was validated by MassARRAY R EpiTYPER TM in a subsample of 47 subjects. CD44 protein levels were measured by ELISA in human plasma.
+
+ RESULTS: Different expression and DNA methylation profiles were identified in LR in comparison to HR. The integrative analysis of both array data identified four genes: CD44, ITPR1, MTSS1 and FBXW5 that were differently methylated and expressed between groups. CD44 showed higher expression and lower DNA methylation levels in LR than in HR. Although differences in CD44 protein levels between LR and HR were not statistically significant, a positive association was observed between CD44 mRNA expression and protein levels.
+
+ CONCLUSIONS: In summary, the combination of a genome-wide methylation and expression array dataset can be a useful strategy to identify novel genes that might be considered as predictors of the dietary response. CD44 gene transcription and methylation may be a possible candidate biomarker for weight-loss prediction.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CD44 protein, human). 0 (Hyaluronan Receptors).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00394-018-1750-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Samblas&issn=1436-6207&title=European+Journal+of+Nutrition&atitle=An+integrated+transcriptomic+and+epigenomic+analysis+identifies+CD44+gene+as+a+potential+biomarker+for+weight+loss+within+an+energy-restricted+program.&volume=58&issue=5&spage=1971&epage=1980&date=2019&doi=10.1007%2Fs00394-018-1750-x&pmid=29948221&sid=OVID:medline
+
+<1919>
+Unique Identifier
+ 29907930
+Title
+ Characterization of a diet-induced obesity rat model for periodontal research.
+Source
+ Clinical Oral Investigations. 23(2):937-946, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Damanaki A; Nokhbehsaim M; Hiththetiya K; Memmert S; Gao J; Nguyen KA; Gotz W; Jager A; Wahl G; Deschner J
+Author NameID
+ Deschner, James; ORCID: http://orcid.org/0000-0002-8808-8769
+Authors Full Name
+ Damanaki, Anna; Nokhbehsaim, Marjan; Hiththetiya, Kanishka; Memmert, Svenja; Gao, Jinlong; Nguyen, Ky-Anh; Gotz, Werner; Jager, Andreas; Wahl, Gerhard; Deschner, James.
+Institution
+ Damanaki, Anna. Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111, Bonn, Germany.
+ Nokhbehsaim, Marjan. Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111, Bonn, Germany.
+ Hiththetiya, Kanishka. Department of Pathology, University of Bonn, Bonn, Germany.
+ Memmert, Svenja. Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111, Bonn, Germany.
+ Memmert, Svenja. Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
+ Gao, Jinlong. Westmead Institute for Medical Research and Faculty of Dentistry, University of Sydney, Sydney, Australia.
+ Nguyen, Ky-Anh. Westmead Institute for Medical Research and Faculty of Dentistry, University of Sydney, Sydney, Australia.
+ Gotz, Werner. Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
+ Jager, Andreas. Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
+ Wahl, Gerhard. Department of Oral Surgery, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
+ Deschner, James. Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstrasse 17, 53111, Bonn, Germany. james.deschner@uni-bonn.de.
+ Deschner, James. Noel Martin Visiting Chair, Faculty of Dentistry, University of Sydney, Sydney, Australia. james.deschner@uni-bonn.de.
+ Deschner, James. Department of Periodontology and Operative Dentistry, University Medical Center, Johannes Gutenberg University, Augustusplatz 2, 55131, Mainz, Australia. james.deschner@uni-bonn.de.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ Animals
+ Biomarkers/bl [Blood]
+ *Diet, High-Fat
+ *Dietary Sucrose/ad [Administration & Dosage]
+ Disease Models, Animal
+ Leptin/bl [Blood]
+ Lipids/bl [Blood]
+ Male
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Periodontitis/bl [Blood]
+ *Periodontitis/et [Etiology]
+ Rats
+ Rats, Wistar
+Keyword Heading
+ Adipokine
+ Adipose tissue
+ Animal model
+ Gingiva
+ Obesity
+ Serum
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: Obesity is associated with periodontitis, but the mechanisms underlying this association have yet to be unraveled. The present investigation was to evaluate a common rat model, in which obesity is induced by high-fat, high-sucrose diet (HFSD), for its applicability in periodontal research.
+
+ MATERIALS AND METHODS: Ten male Wistar rats were fed a 3-month HFSD along with a matching control group. Afterwards, the body weight, adipocyte morphology, leptin and adiponectin levels in adipose tissue, gingiva, and serum as well as the serum levels of triglyceride, cholesterol, and glucose were analyzed. For statistical analyses, parametric and non-parametric tests were applied (p < 0.05).
+
+ RESULTS: Body weight was significantly higher in the HFSD group after dieting as compared to control. HFSD caused a significant increase in serum triglyceride, low-density lipoprotein cholesterol, and leptin levels and a significant decrease in high-density lipoprotein cholesterol. Furthermore, adipose tissue from HFSD rats exhibited significantly larger adipocytes, displayed a significant upregulation of leptin and, surprisingly, elevated adiponectin levels, which is in contrast to chronic obesity in humans. Although leptin and adiponectin were also observed in gingival biopsies, no obvious differences between the groups were found.
+
+ CONCLUSIONS: Although this rat diet-induced obesity model is characterized by changes typical of obesity, it also has limitations, which have to be considered when data, especially with regard to adipokines, are extrapolated to humans.
+
+ CLINICAL RELEVANCE: The rodent diet-induced obesity model may be useful for unraveling pathomechanisms underlying the association between obesity and periodontal destruction but conclusions have to be drawn with caution.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Dietary Sucrose). 0 (Leptin). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00784-018-2514-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Damanaki&issn=1432-6981&title=Clinical+Oral+Investigations&atitle=Characterization+of+a+diet-induced+obesity+rat+model+for+periodontal+research.&volume=23&issue=2&spage=937&epage=946&date=2019&doi=10.1007%2Fs00784-018-2514-y&pmid=29907930&sid=OVID:medline
+
+<1920>
+Unique Identifier
+ 29907846
+Title
+ Greater blood volume and Hb mass in obese women quantified by the carbon monoxide-rebreathing method affects interpretation of iron biomarkers and iron requirements.
+Source
+ International Journal of Obesity. 43(5):999-1008, 2019 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cepeda-Lopez AC; Zimmermann MB; Wussler S; Melse-Boonstra A; Naef N; Mueller SM; Toigo M; Herter-Aeberli I
+Authors Full Name
+ Cepeda-Lopez, Ana C; Zimmermann, Michael B; Wussler, Sophia; Melse-Boonstra, Alida; Naef, Nicole; Mueller, Sandro Manuel; Toigo, Marco; Herter-Aeberli, Isabelle.
+Institution
+ Cepeda-Lopez, Ana C. Division of Human Nutrition, Wageningen University (WU), Wageningen, The Netherlands. ana.cepeda@udem.edu.
+ Cepeda-Lopez, Ana C. Health Sciences Division, University of Monterrey (UDEM), Monterrey, Mexico. ana.cepeda@udem.edu.
+ Zimmermann, Michael B. Laboratory of Human Nutrition, ETH Zurich, Zurich, Switzerland.
+ Wussler, Sophia. Laboratory of Human Nutrition, ETH Zurich, Zurich, Switzerland.
+ Melse-Boonstra, Alida. Division of Human Nutrition, Wageningen University (WU), Wageningen, The Netherlands.
+ Naef, Nicole. University Hospital Balgrist, Balgrist Move>Med, Zurich, Switzerland.
+ Mueller, Sandro Manuel. Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
+ Mueller, Sandro Manuel. Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland.
+ Toigo, Marco. Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland.
+ Toigo, Marco. University Hospital Balgrist, Laboratory for Muscle Plasticity, Zurich, Switzerland.
+ Herter-Aeberli, Isabelle. Laboratory of Human Nutrition, ETH Zurich, Zurich, Switzerland.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ Adult
+ *Anemia, Iron-Deficiency/me [Metabolism]
+ Anemia, Iron-Deficiency/pp [Physiopathology]
+ Biomarkers/me [Metabolism]
+ *Blood Volume/ph [Physiology]
+ Blood Volume Determination
+ Body Mass Index
+ *Carbon Monoxide/me [Metabolism]
+ *Carboxyhemoglobin/an [Analysis]
+ Carboxyhemoglobin/me [Metabolism]
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Iron/me [Metabolism]
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Reproducibility of Results
+ Respiration
+ Young Adult
+Abstract
+ BACKGROUND/OBJECTIVE: Iron deficiency (ID) is common in overweight and obese individuals (OW/OB) but the mechanism is uncertain. Greater blood volume (BV) in OW/OB may increase hemoglobin (Hb) mass and iron requirements, and confound iron biomarkers by hemodilution. Quantification of BV/PV changes in OW/OB is challenging and a formula to estimate BV/PV based on anthropometric indices would be valuable. In normal weight (NW) and OW/OB women, we aimed at: (1) measure BV and assess whether differences in BV affect concentrations and total circulating mass of Hb and iron biomarkers; (2) develop an algorithm describing BV in OW/OB.
+
+ SUBJECTS/METHODS: In a cross-sectional study, we measured BV in NW, OW, and OB non-anemic women (n = 62) by using the carbon monoxide-rebreathing method, body composition by dual energy X-ray absorptiometry, and iron and inflammatory status.
+
+ RESULTS: OW and OB women had 11 and 16% higher mean BV and PV compared to NW (P < 0.05), respectively. In OW/OB compared to NW, total circulating masses of IL-6, hepcidin, Hb, and sTfR were higher, while total mass of serum iron was lower (for all, P < 0.05). An equation including height, body mass and lean mass to estimate BV in all BMI groups (R2 = 0.76).
+
+ CONCLUSION: An equation based on anthropometric indices provides a good estimate of increased BV in OW/OB women. In OW/OB women, there is an increase in Hb mass that likely increases iron requirements for erythropoiesis and circulating TfR mass. At the same time, higher hepcidin concentrations may lower serum iron mass. Both these mechanisms may increase risk for ID in OW/OB women.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 7U1EE4V452 (Carbon Monoxide). 9061-29-4 (Carboxyhemoglobin). E1UOL152H7 (Iron).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0127-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cepeda-Lopez&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Greater+blood+volume+and+Hb+mass+in+obese+women+quantified+by+the+carbon+monoxide-rebreathing+method+affects+interpretation+of+iron+biomarkers+and+iron+requirements.&volume=43&issue=5&spage=999&epage=1008&date=2019&doi=10.1038%2Fs41366-018-0127-9&pmid=29907846&sid=OVID:medline
+
+<1921>
+Unique Identifier
+ 29898625
+Title
+ Branched-chain amino acids are associated with metabolic parameters in bipolar disorder.
+Source
+ World Journal of Biological Psychiatry. 20(10):821-826, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fellendorf FT; Platzer M; Pilz R; Rieger A; Kapfhammer HP; Mangge H; Dalkner N; Zelzer S; Meinitzer A; Birner A; Bengesser SA; Queissner R; Hamm C; Hartleb R; Reininghaus EZ
+Authors Full Name
+ Fellendorf, Frederike T; Platzer, Martina; Pilz, Rene; Rieger, Alexandra; Kapfhammer, Hans-Peter; Mangge, Harald; Dalkner, Nina; Zelzer, Sieglinde; Meinitzer, Andreas; Birner, Armin; Bengesser, Susanne A; Queissner, Robert; Hamm, Carlo; Hartleb, Riccarda; Reininghaus, Eva Z.
+Institution
+ Fellendorf, Frederike T. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Platzer, Martina. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Pilz, Rene. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Rieger, Alexandra. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Kapfhammer, Hans-Peter. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Mangge, Harald. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
+ Dalkner, Nina. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Zelzer, Sieglinde. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
+ Meinitzer, Andreas. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
+ Birner, Armin. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Bengesser, Susanne A. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Queissner, Robert. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Hamm, Carlo. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Hartleb, Riccarda. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+ Reininghaus, Eva Z. Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
+MeSH Subject Headings
+ Adult
+ *Amino Acids, Branched-Chain/an [Analysis]
+ *Biomarkers/an [Analysis]
+ *Bipolar Disorder/di [Diagnosis]
+ *Bipolar Disorder/me [Metabolism]
+ Case-Control Studies
+ Chromatography, High Pressure Liquid
+ Comorbidity
+ Energy Metabolism
+ Female
+ Humans
+ Isoleucine/an [Analysis]
+ Leucine/an [Analysis]
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ Sex Factors
+ Valine/an [Analysis]
+Keyword Heading
+ Bipolar affective disorder
+ biological psychiatry
+ biomarker for somatic health state
+ branched-chain amino acids
+ diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objectives: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. Methods: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analysed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters. Results: BD and HC did not differ in valine and isoleucine, whereas leucine was significantly lower in BD. Furthermore, correlations were found between BCAAs and anthropometric and glucose metabolism data. All BCAAs correlated with lipid metabolism parameters in females. There were no associations between BCAAs and long-term clinical parameters of BD. A negative correlation was found between valine and Hamilton Depression-Scale, and Beck Depression Inventory II, in male individualsConclusions: Our results indicate the utility of BCAAs as biomarkers for the current state of health, also in BD. As BD individuals have a high risk for overweight/obesity, in association with comorbid medical conditions (e.g. cardiovascular diseases or insulin resistance), health state markers are urgently required. However, no illness-specific associations were found in this euthymic/subsyndromal BD group.
+Registry Number/Name of Substance
+ 0 (Amino Acids, Branched-Chain). 0 (Biomarkers). 04Y7590D77 (Isoleucine). GMW67QNF9C (Leucine). HG18B9YRS7 (Valine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f15622975.2018.1487077
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fellendorf&issn=1562-2975&title=World+Journal+of+Biological+Psychiatry&atitle=Branched-chain+amino+acids+are+associated+with+metabolic+parameters+in+bipolar+disorder.&volume=20&issue=10&spage=821&epage=826&date=2019&doi=10.1080%2F15622975.2018.1487077&pmid=29898625&sid=OVID:medline
+
+<1922>
+Unique Identifier
+ 29893815
+Title
+ Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
+Source
+ Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 74(3):290-298, 2019 02 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Valcarcel-Ares MN; Tucsek Z; Kiss T; Giles CB; Tarantini S; Yabluchanskiy A; Balasubramanian P; Gautam T; Galvan V; Ballabh P; Richardson A; Freeman WM; Wren JD; Deak F; Ungvari Z; Csiszar A
+Authors Full Name
+ Valcarcel-Ares, Marta Noa; Tucsek, Zsuzsanna; Kiss, Tamas; Giles, Cory B; Tarantini, Stefano; Yabluchanskiy, Andriy; Balasubramanian, Priya; Gautam, Tripti; Galvan, Veronica; Ballabh, Praveen; Richardson, Arlan; Freeman, Willard M; Wren, Jonathan D; Deak, Ferenc; Ungvari, Zoltan; Csiszar, Anna.
+Institution
+ Valcarcel-Ares, Marta Noa. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Tucsek, Zsuzsanna. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Kiss, Tamas. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Giles, Cory B. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Giles, Cory B. Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology Research Program, Oklahoma City.
+ Tarantini, Stefano. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Yabluchanskiy, Andriy. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Balasubramanian, Priya. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Gautam, Tripti. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Galvan, Veronica. Barshop Institute for Longevity and Aging Studies and Department of Physiology, University of Texas Health Science Center at San Antonio.
+ Ballabh, Praveen. Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
+ Richardson, Arlan. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Richardson, Arlan. Oklahoma City VA Medical Center, Oklahoma City.
+ Freeman, Willard M. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Wren, Jonathan D. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Wren, Jonathan D. Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology Research Program, Oklahoma City.
+ Deak, Ferenc. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Deak, Ferenc. Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Ungvari, Zoltan. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Ungvari, Zoltan. Department of Medical Physics and Informatics, University of Szeged, Hungary.
+ Csiszar, Anna. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
+ Csiszar, Anna. Department of Pulmonology, Semmelweis University, Budapest, Hungary.
+MeSH Subject Headings
+ *Aging/ph [Physiology]
+ Animals
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ *Cognitive Dysfunction/et [Etiology]
+ Cognitive Dysfunction/pp [Physiopathology]
+ Disease Models, Animal
+ *Eicosanoids/me [Metabolism]
+ *Hippocampus/me [Metabolism]
+ Inflammation
+ Male
+ Mice
+ Mice, Inbred C57BL
+ *Neuronal Plasticity/ph [Physiology]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ *Obesity/px [Psychology]
+ Oxidative Stress/ph [Physiology]
+Keyword Heading
+ Inflammaging
+ Metabolic syndrome
+ Mild cognitive impairment
+ VCI
+ Vascular cognitive impairment
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ There is strong evidence that obesity has deleterious effects on cognitive function of older adults. Previous preclinical studies demonstrate that obesity in aging is associated with a heightened state of systemic inflammation, which exacerbates blood-brain barrier disruption, promoting neuroinflammation and oxidative stress. To test the hypothesis that synergistic effects of obesity and aging on inflammatory processes exert deleterious effects on hippocampal function, young and aged C57BL/6 mice were rendered obese by chronic feeding of a high-fat diet followed by assessment of learning and memory function, measurement of hippocampal long-term potentiation (LTP), assessment of changes in hippocampal expression of genes relevant for synaptic function and determination of synaptic density. Because there is increasing evidence that altered production of lipid mediators modulate LTP, neuroinflammation and neurovascular coupling responses, the effects of obesity on hippocampal levels of relevant eicosanoid mediators were also assessed. We found that aging exacerbates obesity-induced microglia activation, which is associated with deficits in hippocampal-dependent learning and memory tests, impaired LTP, decreased synaptic density, and dysregulation of genes involved in regulation of synaptic plasticity. Obesity in aging also resulted in an altered hippocampal eicosanoid profile, including decreases in vasodilator and pro-LTP epoxy-eicosatrienoic acids (EETs). Collectively, our results taken together with previous findings suggest that obesity in aging promotes hippocampal inflammation, which in turn may contribute to synaptic dysfunction and cognitive impairment. Copyright © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Eicosanoids).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fgerona%2fgly127
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Valcarcel-Ares&issn=1079-5006&title=Journals+of+Gerontology+Series+A-Biological+Sciences+%26+Medical+Sciences&atitle=Obesity+in+Aging+Exacerbates+Neuroinflammation%2C+Dysregulating+Synaptic+Function-Related+Genes+and+Altering+Eicosanoid+Synthesis+in+the+Mouse+Hippocampus%3A+Potential+Role+in+Impaired+Synaptic+Plasticity+and+Cognitive+Decline.&volume=74&issue=3&spage=290&epage=298&date=2019&doi=10.1093%2Fgerona%2Fgly127&pmid=29893815&sid=OVID:medline
+
+<1923>
+Unique Identifier
+ 29861375
+Title
+ Arterial pH selectively predicts critical care needs in emergency department obese patients with acute dyspnea: A prospective comparative study.
+Source
+ American Journal of Emergency Medicine. 37(1):67-72, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gourhant V; Vuillot O; Claret PG; Lefebvre S; Schaub R; Flacher A; Dumont R; Sebbane M
+Authors Full Name
+ Gourhant, Vincent; Vuillot, Olivier; Claret, Pierre-Geraud; Lefebvre, Sophie; Schaub, Roxane; Flacher, Alexandre; Dumont, Richard; Sebbane, Mustapha.
+Institution
+ Gourhant, Vincent. Departement des urgences, CHU Montpellier - Univ Montpellier, Montpellier, France.
+ Vuillot, Olivier. Departement des urgences, CHU Montpellier - Univ Montpellier, Montpellier, France.
+ Claret, Pierre-Geraud. Departement des urgences, CHU Nimes - Univ Montpellier, Montpellier, France.
+ Lefebvre, Sophie. Departement des urgences, CHU Montpellier - Univ Montpellier, Montpellier, France.
+ Schaub, Roxane. Departement d'information medicale, CHU Montpellier - Univ Montpellier, Montpellier, France.
+ Flacher, Alexandre. Departement des urgences, CHU Montpellier - Univ Montpellier, Montpellier, France.
+ Dumont, Richard. Departement des urgences, CHU Montpellier - Univ Montpellier, Montpellier, France.
+ Sebbane, Mustapha. Departement des urgences, CHU Montpellier - Univ Montpellier, Montpellier, France. Electronic address: m-sebbane@chu-montpellier.fr.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Critical Care/mt [Methods]
+ *Critical Care
+ *Dyspnea/bl [Blood]
+ Dyspnea/et [Etiology]
+ *Dyspnea/pp [Physiopathology]
+ *Emergency Service, Hospital
+ Female
+ Humans
+ Hydrogen-Ion Concentration
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ *Obesity/pp [Physiopathology]
+ Predictive Value of Tests
+ Prognosis
+ Prospective Studies
+ ROC Curve
+Keyword Heading
+ Blood gas analysis
+ Dyspnea
+ Emergency department
+ Intensive care unit
+ Obesity
+ Prognosis
+ pH
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Obese patients with acute dyspnea may be prone to misorientation from the emergency department (ED), due to impaired gas exchange evaluation and altered basal respiratory profiles. This study aims to evaluate the prognostic value of arterial blood pH in obese ED patients with acute dyspnea in comparison to non-obese counterparts.
+
+ METHODS: Single-center observational study of a cohort of 400 consecutive ED patients with acute dyspnea. The primary endpoint was a composite of Intensive Care Unit admission (with critical care needs) or in ED mortality. Predictors of the primary endpoint were assessed using multivariable logistic regression and ROC curve analysis, in obese (BMI>=30kg.m-2) and non-obese patients.
+
+ RESULTS: 252 patients who had arterial blood gas testing were analyzed including 76 (30%) obese comparable to non-obese in terms of clinical history. 51 patients were admitted to ICU and 2 deceased before admission (20 obese (26%) vs 33 non-obese (19%); p=0.17). Factors associated with ICU admission were arterial blood pH (pH<7.36 vs pH>=7.36) and gender. In multivariate models adjusted for risk factors, pH remained the sole independent predictor in obese patients, with no predictive value in non-obese patients (ROC AUC: 0.74, 95% CI [0.60; 0.87], optimal threshold for pH: 7.36, odds ratio: 10.5 [95% CI 3.18; 34.68]).
+
+ CONCLUSION: Arterial blood pH may selectively predict critical care needs in ED obese patients with acute dyspnea, in comparison to non-obese. A falsely reassuring pH<7.36 should be regarded as a marker of severity when assessing acute dyspnea in obese ED patients. Copyright © 2018. Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article. Observational Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ajem.2018.04.059
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gourhant&issn=0735-6757&title=American+Journal+of+Emergency+Medicine&atitle=Arterial+pH+selectively+predicts+critical+care+needs+in+emergency+department+obese+patients+with+acute+dyspnea%3A+A+prospective+comparative+study.&volume=37&issue=1&spage=67&epage=72&date=2019&doi=10.1016%2Fj.ajem.2018.04.059&pmid=29861375&sid=OVID:medline
+
+<1924>
+Unique Identifier
+ 29795469
+Title
+ Are BMI and inflammatory markers independently associated with physical fatigability in old age?.
+Source
+ International Journal of Obesity. 43(4):832-841, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cooper R; Popham M; Santanasto AJ; Hardy R; Glynn NW; Kuh D
+Author NameID
+ Cooper, Rachel; ORCID: http://orcid.org/0000-0003-3370-5720
+Authors Full Name
+ Cooper, Rachel; Popham, Maria; Santanasto, Adam J; Hardy, Rebecca; Glynn, Nancy W; Kuh, Diana.
+Institution
+ Cooper, Rachel. MRC Unit for Lifelong Health and Ageing at UCL, 33 Bedford Place, London, WC1B 5JU, UK. rachel.cooper@ucl.ac.uk.
+ Popham, Maria. MRC Unit for Lifelong Health and Ageing at UCL, 33 Bedford Place, London, WC1B 5JU, UK.
+ Santanasto, Adam J. Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA, USA.
+ Hardy, Rebecca. MRC Unit for Lifelong Health and Ageing at UCL, 33 Bedford Place, London, WC1B 5JU, UK.
+ Glynn, Nancy W. Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA, USA.
+ Kuh, Diana. MRC Unit for Lifelong Health and Ageing at UCL, 33 Bedford Place, London, WC1B 5JU, UK.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *C-Reactive Protein/me [Metabolism]
+ *Fatigue/bl [Blood]
+ Fatigue/et [Etiology]
+ Fatigue/pp [Physiopathology]
+ Female
+ Geriatric Assessment
+ Health Surveys
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/pp [Physiopathology]
+ *Interleukin-6/bl [Blood]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Predictive Value of Tests
+Abstract
+ BACKGROUND: Obesity and chronic low-grade inflammation have both been implicated in the onset of physical fatigue. However, few studies have investigated the independence of these associations in older community-dwelling populations. We therefore aimed to investigate the associations of body mass index (BMI) and inflammatory markers at age 60-64 with perceived physical fatigability at age 68 and to assess whether any such associations were independent of each other and potential confounding factors. A secondary aim was to investigate whether any association with BMI extended back into earlier adulthood.
+
+ METHODS: Participants of the MRC National Survey of Health and Development (N = 1580) had BMI and levels of interleukin-6 (IL-6) and C-reactive protein (CRP) measured during clinical assessments at age 60-64. These were related to self-perceived physical fatigability assessed at age 68 using the Pittsburgh Fatigability Scale (PFS) (total score:0 (no physical fatigue)-50 (extreme physical fatigue)).
+
+ RESUTS: Women had higher mean PFS scores than men (mean (SD): 16.0 (9.1) vs 13.2 (8.9), p < 0.01). In sex-adjusted models, BMI, CRP and IL-6 were each associated with PFS scores. When all three factors were included in the same model, BMI and IL-6 remained associated with PFS scores whereas CRP did not. After adjustment for a range of potential confounders, associations of BMI and IL-6 with PFS scores were still evident; fully adjusted differences in mean PFS score = 3.41 (95% CI: 0.59, 6.24) and 1.65 (0.46, 2.84) for underweight and obese participants when compared with normal weight and, 2.78 (1.65, 3.91) when comparing those with an IL-6 of 2.51-8.49 pg/mL with levels <1.50.
+
+ CONCLUSIONS: BMI and inflammation may both be suitable targets for intervention to reduce the burden of physical fatigability in later life. Further, interventions that target both obesity and elevated levels of IL-6 are likely to be more effective than those focusing on only one.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0087-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cooper&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Are+BMI+and+inflammatory+markers+independently+associated+with+physical+fatigability+in+old+age%3F.&volume=43&issue=4&spage=832&epage=841&date=2019&doi=10.1038%2Fs41366-018-0087-0&pmid=29795469&sid=OVID:medline
+
+<1925>
+Unique Identifier
+ 29724666
+Title
+ Should early surgical intervention be recommended for obese patients with type two diabetes mellitus?.
+Source
+ Primary care diabetes. 13(2):187, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ahmad Z; Ahmad A
+Authors Full Name
+ Ahmad, Zainab; Ahmad, Aysha.
+Institution
+ Ahmad, Zainab. Dow Medical College, Baba-e-Urdu Road, M.A. Jinnah Road, Karachi, Pakistan. Electronic address: ahmadzainab97@gmail.com.
+ Ahmad, Aysha. Dow Medical College, Baba-e-Urdu Road, M.A. Jinnah Road, Karachi, Pakistan.
+MeSH Subject Headings
+ Bariatric Surgery/ae [Adverse Effects]
+ Bariatric Surgery/mo [Mortality]
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/mo [Mortality]
+ Diabetes Mellitus, Type 2/pp [Physiopathology]
+ *Diabetes Mellitus, Type 2/su [Surgery]
+ Humans
+ Obesity/bl [Blood]
+ Obesity/mo [Mortality]
+ Obesity/pp [Physiopathology]
+ *Obesity/su [Surgery]
+ Quality of Life
+ Risk Factors
+ Treatment Outcome
+ Weight Loss
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Letter.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.pcd.2018.03.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ahmad&issn=1878-0210&title=Primary+care+diabetes&atitle=Should+early+surgical+intervention+be+recommended+for+obese+patients+with+type+two+diabetes+mellitus%3F.&volume=13&issue=2&spage=187&epage=&date=2019&doi=10.1016%2Fj.pcd.2018.03.006&pmid=29724666&sid=OVID:medline
+
+<1926>
+Unique Identifier
+ 29717278
+Title
+ Role of obesity in the release of extracellular nucleosomes in acute pancreatitis: a clinical and experimental study.
+Source
+ International Journal of Obesity. 43(1):158-168, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Perez S; Finamor I; Marti-Andres P; Pereda J; Campos A; Domingues R; Haj F; Sabater L; de-Madaria E; Sastre J
+Authors Full Name
+ Perez, Salvador; Finamor, Isabela; Marti-Andres, Pablo; Pereda, Javier; Campos, Ana; Domingues, Rosario; Haj, Fawaz; Sabater, Luis; de-Madaria, Enrique; Sastre, Juan.
+Institution
+ Perez, Salvador. Department of Physiology, School of Pharmacy, University of Valencia, Av. Vicente Andres Estelles s/n, 46100, Burjasot, Valencia, Spain.
+ Finamor, Isabela. Department of Physiology, School of Pharmacy, University of Valencia, Av. Vicente Andres Estelles s/n, 46100, Burjasot, Valencia, Spain.
+ Finamor, Isabela. Department of Physiology and Pharmacology, Federal University of Santa Maria (UFSM), 1000, Santa Maria, Brazil.
+ Marti-Andres, Pablo. Department of Physiology, School of Pharmacy, University of Valencia, Av. Vicente Andres Estelles s/n, 46100, Burjasot, Valencia, Spain.
+ Pereda, Javier. Department of Physiology, School of Pharmacy, University of Valencia, Av. Vicente Andres Estelles s/n, 46100, Burjasot, Valencia, Spain.
+ Campos, Ana. Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
+ Domingues, Rosario. Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
+ Haj, Fawaz. Department of Nutrition, University of California Davis, One Shields Ave, Davis, CA, 95616, USA.
+ Sabater, Luis. Department of Surgery, University of Valencia, University Clinic Hospital, Av. Blasco Ibanez 15, 46010, Valencia, Spain.
+ de-Madaria, Enrique. Department of Gastroenterology, University General Hospital of Alicante, Institute of Sanitary and Biomedical Research of Alicante (ISABIAL), Alicante, Spain.
+ Sastre, Juan. Department of Physiology, School of Pharmacy, University of Valencia, Av. Vicente Andres Estelles s/n, 46100, Burjasot, Valencia, Spain. juan.sastre@uv.es.
+MeSH Subject Headings
+ Acute Disease
+ Adult
+ Aged
+ Aged, 80 and over
+ Animals
+ *Ascites/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ Body Mass Index
+ Disease Models, Animal
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Nucleosomes/me [Metabolism]
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ *Pancreas/pa [Pathology]
+ Pancreatitis/me [Metabolism]
+ *Pancreatitis/pp [Physiopathology]
+ Peritoneal Lavage
+ Rats
+ Rats, Zucker
+ Thinness
+Abstract
+ BACKGROUND/OBJECTIVES: A high body mass index increases the risk of severe pancreatitis and associated mortality. Our aims were: (1) To determine whether obesity affects the release of extracellular nucleosomes in patients with pancreatitis; (2) To determine whether pancreatic ascites confers lipotoxicity and triggers the release of extracellular nucleosomes in lean and obese rats.
+
+ METHODS: DNA and nucleosomes were determined in plasma from patients with mild or moderately severe acute pancreatitis either with normal or high body mass index (BMI). Lipids from pancreatic ascites from lean and obese rats were analyzed and the associated toxicity measured in vitro in RAW 264.7 macrophages. The inflammatory response, extracellular DNA and nucleosomes were determined in lean or obese rats with pancreatitis after peritoneal lavage.
+
+ RESULTS: Nucleosome levels in plasma from obese patients with mild pancreatitis were higher than in normal BMI patients; these levels markedly increased in obese patients with moderately severe pancreatitis vs. those with normal BMI. Ascites from obese rats exhibited high levels of palmitic, oleic, stearic, and arachidonic acids. Necrosis and histone 4 citrullination-marker of extracellular traps-increased in macrophages incubated with ascites from obese rats but not with ascites from lean rats. Peritoneal lavage abrogated the increase in DNA and nucleosomes in plasma from lean or obese rats with pancreatitis. It prevented fat necrosis and induction of HIF-related genes in lung.
+
+ CONCLUSIONS: Extracellular nucleosomes are intensely released in obese patients with acute pancreatitis. Pancreatitis-associated ascitic fluid triggers the release of extracellular nucleosomes in rats with severe pancreatitis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Nucleosomes).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41366-018-0073-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Perez&issn=0307-0565&title=International+Journal+of+Obesity&atitle=Role+of+obesity+in+the+release+of+extracellular+nucleosomes+in+acute+pancreatitis%3A+a+clinical+and+experimental+study.&volume=43&issue=1&spage=158&epage=168&date=2019&doi=10.1038%2Fs41366-018-0073-6&pmid=29717278&sid=OVID:medline
+
+<1927>
+Unique Identifier
+ 29687417
+Title
+ Elevation of isoprostanes in polycystic ovary syndrome and its relationship with cardiovascular risk factors.
+Source
+ Journal of Endocrinological Investigation. 42(1):75-83, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Calzada M; Lopez N; Noguera JA; Mendiola J; Torres AM
+Authors Full Name
+ Calzada, M; Lopez, N; Noguera, J A; Mendiola, J; Torres, A M.
+Institution
+ Calzada, M. Clinical Analysis Service, Hospital University "Virgen de la Arrixaca", Ctra. Madrid-Cartagena, s/n, El Palmar, 30120, Murcia, Spain. mireyacalzada9@gmail.com.
+ Lopez, N. Clinical Analysis Service, Hospital University "Virgen de la Arrixaca", Ctra. Madrid-Cartagena, s/n, El Palmar, 30120, Murcia, Spain.
+ Noguera, J A. Clinical Analysis Service, Hospital University "Virgen de la Arrixaca", Ctra. Madrid-Cartagena, s/n, El Palmar, 30120, Murcia, Spain.
+ Mendiola, J. Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, University of Murcia, Murcia, Spain.
+ Torres, A M. Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, University of Murcia, Murcia, Spain.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Case-Control Studies
+ *Dinoprost/aa [Analogs & Derivatives]
+ Dinoprost/bl [Blood]
+ Female
+ Humans
+ Isoprostanes/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ *Polycystic Ovary Syndrome/ep [Epidemiology]
+ Risk Factors
+ Young Adult
+Keyword Heading
+ 8-Isoprostanes
+ Infertility
+ Insulin resistance
+ Oxidative stress
+ Polycystic ovary syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: To evaluate the plasma level of 8-isoprostanes in women with polycystic ovary syndrome. To also investigate whether there is a relationship between 8-isoprostanes and several cardiovascular risk factors.
+
+ METHODS: A total of 125 women with polycystic ovary syndrome and 169 healthy women were enrolled in this case-control study. 8-Isoprostanes and different parameters were measured in all subjects. Patients were evaluated for the presence of polycystic ovary syndrome according to the Rotterdam Consensus Conference criteria.
+
+ RESULTS: 8-Isoprostanes levels were significantly higher in patients with polycystic ovary syndrome (138.4 +/- 104.1 pg/mL) compared with control group (68.6 +/- 34.3 pg/mL) (p < 0.001). The mean of triglycerides, lipid accumulation product, C-reactive protein, homocysteine, insulin, and homeostatic model assessment for insulin resistance were significantly higher in polycystic ovary syndrome patients with high 8-isoprostanes than those with normal 8-isoprostanes (p < 0.05). The Pearson correlation analyses showed that 8-isoprostanes levels in polycystic ovary syndrome group had a positive correlation with waist circumference, triglycerides, low-density lipoprotein cholesterol, apolipoprotein B, homocysteine, insulin, homeostatic model assessment for insulin resistance.
+
+ CONCLUSIONS: Patients with polycystic ovary syndrome have higher 8-isoprostanes levels and it is associated with several cardiovascular risk factors.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Isoprostanes). 27415-26-5 (8-epi-prostaglandin F2alpha). B7IN85G1HY (Dinoprost).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs40618-018-0888-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Calzada&issn=0391-4097&title=Journal+of+Endocrinological+Investigation&atitle=Elevation+of+isoprostanes+in+polycystic+ovary+syndrome+and+its+relationship+with+cardiovascular+risk+factors.&volume=42&issue=1&spage=75&epage=83&date=2019&doi=10.1007%2Fs40618-018-0888-y&pmid=29687417&sid=OVID:medline
+
+<1928>
+Unique Identifier
+ 29604350
+Title
+ Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice.
+Source
+ Bone. 118:20-31, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ McCabe LR; Irwin R; Tekalur A; Evans C; Schepper JD; Parameswaran N; Ciancio M
+Authors Full Name
+ McCabe, Laura R; Irwin, Regina; Tekalur, Arjun; Evans, Christian; Schepper, Jonathan D; Parameswaran, Narayanan; Ciancio, Mae.
+Institution
+ McCabe, Laura R. Department of Physiology, Michigan State University, East Lansing, MI, United States; Department of Radiology, Michigan State University, East Lansing, MI, United States; Biomedical Imaging Research Center, Michigan State University, East Lansing, MI, United States. Electronic address: mccabel@msu.edu.
+ Irwin, Regina. Department of Physiology, Michigan State University, East Lansing, MI, United States.
+ Tekalur, Arjun. Department of Mechanical Engineering, Michigan State University, East Lansing, MI, United States.
+ Evans, Christian. Physical Therapy Program, Midwestern University, Downers Grove, IL, United States.
+ Schepper, Jonathan D. Department of Physiology, Michigan State University, East Lansing, MI, United States.
+ Parameswaran, Narayanan. Department of Physiology, Michigan State University, East Lansing, MI, United States.
+ Ciancio, Mae. Biomedical Sciences Program, Midwestern University, Downers Grove, IL, United States. Electronic address: mcianc@midwestern.edu.
+Comments
+ Comment in (CIN)
+ Erratum in (EIN)
+MeSH Subject Headings
+ *Adiposity
+ Animals
+ Biomarkers/bl [Blood]
+ *Bone Marrow/pa [Pathology]
+ Bone Resorption/bl [Blood]
+ Bone Resorption/co [Complications]
+ Bone Resorption/pp [Physiopathology]
+ *Bone Resorption/pc [Prevention & Control]
+ Cancellous Bone/pa [Pathology]
+ Cancellous Bone/pp [Physiopathology]
+ Cortical Bone/pa [Pathology]
+ Cortical Bone/pp [Physiopathology]
+ *Diet, High-Fat/ae [Adverse Effects]
+ Dysbiosis/bl [Blood]
+ Dysbiosis/co [Complications]
+ *Dysbiosis/pc [Prevention & Control]
+ Gastrointestinal Microbiome
+ Male
+ Mice, Inbred C57BL
+ Obesity/pc [Prevention & Control]
+ Osteoblasts/me [Metabolism]
+ Osteoclasts/me [Metabolism]
+ Osteogenesis
+ *Physical Conditioning, Animal
+Keyword Heading
+ Actinobacteria
+ Bacteriodetes
+ Bifidobacteriaceae
+ Cancellous bone
+ Cortical bone
+ Exercise
+ Firmicutes
+ Growing
+ Male
+ Microbiome
+ Obesity
+ Osteoporosis
+ Trabecular bone
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balance and bone health. Therefore, we examined whether exercise could prevent HF-induced bone pathology in male mice and determined whether benefits correlate to changes in host intestinal microbiota. Male C57Bl/6 mice were fed either a low fat diet (LF; 10kcal% fat) or a HF diet (60kcal% fat) and put under sedentary or voluntary exercise conditions for 14weeks. Our results indicated that HF diet reduced trabecular bone volume, when corrected for differences in body weight, of both the tibia (40% reduction) and vertebrae (25% reduction) as well and increased marrow adiposity (44% increase). More importantly, these effects were prevented by exercise. Exercise also had a significant effect on several cortical bone parameters and enhanced bone mechanical properties in LF but not HF fed mice. Microbiome analyses indicated that exercise altered the HF induced changes in microbial composition by reducing the Firmicutes/Bacteriodetes ratio. This ratio negatively correlated with bone volume as did levels of Clostridia and Lachnospiraceae. In contrast, the abundance of several Actinobacteria phylum members (i.e., Bifidobacteriaceae) were positively correlated with bone volume. Taken together, exercise can prevent many of the negative effects of a high fat diet on male skeletal health. Exercise induced changes in microbiota composition could represent a novel mechanism that contributes to exercise induced benefits to bone health. Copyright © 2018 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.bone.2018.03.024
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=McCabe&issn=1873-2763&title=Bone&atitle=Exercise+prevents+high+fat+diet-induced+bone+loss%2C+marrow+adiposity+and+dysbiosis+in+male+mice.&volume=118&issue=&spage=20&epage=31&date=2019&doi=10.1016%2Fj.bone.2018.03.024&pmid=29604350&sid=OVID:medline
+
+<1929>
+Unique Identifier
+ 29603657
+Title
+ Changes in Plasma Metabolite Concentrations after a Low-Glycemic Index Diet Intervention.
+Source
+ Molecular Nutrition & Food Research. 63(1):e1700975, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hernandez-Alonso P; Giardina S; Canueto D; Salas-Salvado J; Canellas N; Bullo M
+Authors Full Name
+ Hernandez-Alonso, Pablo; Giardina, Simona; Canueto, Daniel; Salas-Salvado, Jordi; Canellas, Nicolau; Bullo, Monica.
+Institution
+ Hernandez-Alonso, Pablo. Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain, 43201.
+ Hernandez-Alonso, Pablo. CIBERobn Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ Giardina, Simona. Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain, 43201.
+ Giardina, Simona. CIBERobn Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ Canueto, Daniel. Metabolomics Platform, IISPV, Universitat Rovira i Virgili, Avinguda Paisos Catalans, 26, 43007, Tarragona, Spain.
+ Canueto, Daniel. CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, 28029, Spain.
+ Salas-Salvado, Jordi. Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain, 43201.
+ Salas-Salvado, Jordi. CIBERobn Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, 28029, Spain.
+ Canellas, Nicolau. Metabolomics Platform, IISPV, Universitat Rovira i Virgili, Avinguda Paisos Catalans, 26, 43007, Tarragona, Spain.
+ Canellas, Nicolau. CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, 28029, Spain.
+ Bullo, Monica. Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain, 43201.
+ Bullo, Monica. CIBERobn Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, 28029, Spain.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Weight
+ *Diet
+ Diet, Fat-Restricted
+ Female
+ Glycemic Index
+ Humans
+ *Lipids/bl [Blood]
+ Male
+ Obesity/bl [Blood]
+ Obesity/dh [Diet Therapy]
+ Overweight/bl [Blood]
+ *Overweight/dh [Diet Therapy]
+ *Plasma/me [Metabolism]
+ Serine/bl [Blood]
+Keyword Heading
+ glycemic index
+ lipidomics
+ metabolomics
+ nutritional intervention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ SCOPE: To examine whether a low-glycemic index (LGI) diet improves a set of plasma metabolites related to different metabolic diseases, and comparison to a high-glycemic index (HGI) diet and a low-fat (LF) diet.
+
+ METHODS AND RESULTS: A parallel, randomized trial with three intervention diets: an LGI diet, an HGI diet, and an LF diet. A total of 122 adult overweight and obese subjects were enrolled in the study for 6 months. Blood samples were collected at baseline and at the end of the intervention. The plasma metabolomic profile of 102 subjects was analyzed using three different approaches: GC/quadrupole-TOF, LC/quadrupole-TOF, and nuclear magnetic resonance. Both univariate and multivariate analysis were performed. Serine levels were significantly higher following the LGI diet compared to both the HGI and LF diets (q = 0.002), whereas leucine (q = 0.015) and valine (q = 0.024) were lower in the LGI diet compared to the LF diet. A set of two sphingomyelins, two lysophosphatidylcholines, and six phosphatidylcholines were significantly modulated after the LGI diet compared to the HGI and LF diets (q < 0.05). Significant correlations between changes in plasma amino acids and lipid species with changes in body weight, glucose, insulin, and some inflammatory markers are also reported.
+
+ CONCLUSION: These results suggest that an LGI diet modulates certain circulating amino acids and lipid levels. These findings may explain the health benefits attributed to LGI diets in metabolic diseases such as type 2 diabetes. Copyright © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). 452VLY9402 (Serine).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fmnfr.201700975
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hernandez-Alonso&issn=1613-4125&title=Molecular+Nutrition+%26+Food+Research&atitle=Changes+in+Plasma+Metabolite+Concentrations+after+a+Low-Glycemic+Index+Diet+Intervention.&volume=63&issue=1&spage=e1700975&epage=&date=2019&doi=10.1002%2Fmnfr.201700975&pmid=29603657&sid=OVID:medline
+
+<1930>
+Unique Identifier
+ 29564917
+Title
+ Interactive effects of apelin, renin-angiotensin system and nitric oxide in treatment of obesity-induced type 2 diabetes mellitus in male albino rats.
+Source
+ Archives of Physiology & Biochemistry. 125(3):244-254, 2019 Jul.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sabry MM; Mahmoud MM; Shoukry HS; Rashed L; Kamar SS; Ahmed MM
+Authors Full Name
+ Sabry, Maha Mohamed; Mahmoud, Manal Moustafa; Shoukry, Heba Samy; Rashed, Laila; Kamar, Samaa Samir; Ahmed, Mona Mohamed.
+Institution
+ Sabry, Maha Mohamed. a Physiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Mahmoud, Manal Moustafa. a Physiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Shoukry, Heba Samy. a Physiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Rashed, Laila. b Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Kamar, Samaa Samir. c Medical Histology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Ahmed, Mona Mohamed. a Physiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+MeSH Subject Headings
+ Angiotensin II Type 1 Receptor Blockers/ad [Administration & Dosage]
+ Animals
+ *Apelin/ad [Administration & Dosage]
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Diabetes Mellitus, Experimental/et [Etiology]
+ Diabetes Mellitus, Experimental/me [Metabolism]
+ Diabetes Mellitus, Experimental/pa [Pathology]
+ *Diabetes Mellitus, Experimental/pc [Prevention & Control]
+ Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ *Diabetes Mellitus, Type 2/pc [Prevention & Control]
+ Diet, High-Fat/ae [Adverse Effects]
+ Drug Therapy, Combination
+ Enzyme Inhibitors/ad [Administration & Dosage]
+ Insulin/me [Metabolism]
+ Insulin Resistance
+ Losartan/ad [Administration & Dosage]
+ Male
+ NG-Nitroarginine Methyl Ester/ad [Administration & Dosage]
+ *Nitric Oxide/me [Metabolism]
+ *Obesity/co [Complications]
+ Obesity/et [Etiology]
+ Obesity/pa [Pathology]
+ Rats
+ *Renin-Angiotensin System/de [Drug Effects]
+Keyword Heading
+ Type 2 diabetes mellitus (T2DM)
+ apelin
+ endothelial nitric oxide synthase (eNOS)
+ renin-angiotensin system (RAS)
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Apelin and its receptor (APJ) are involved in the regulation of a variety of pathophysiological processes. We studied the effect of apelin treatment on obesity-induced type 2 diabetes mellitus (T2DM) and possible interaction between apelin/APJ system and renin-angiotensin system (RAS). Forty eight male albino rats were divided into two groups: control group and diabetic group. Diabetic group was subdivided into: control diabetic, apelin-treated, apelin + losartan-treated, apelin + l-NAME-treated and losartan-treated diabetic subgroup. Administration of apelin-13 yielded an improvement of IR, dyslipidaemia, inflammation, oxidative stress with significant decrease in AT1R gene expression and significant increase in ACE2 gene expression in adipose tissues. Losartan + apelin yielded a further significant decrease in ATR1 gene expression, glycaemic indices, serum TGs and TPA versus Apelin only. Adding l-NAME in subgroup (2D) reversed the effect of apelin. We suggested that the beneficial effect of Apelin is mainly mediated by NO-activated pathway and/or ACE2/Ang (1-7) dependent pathway.
+Registry Number/Name of Substance
+ 0 (Angiotensin II Type 1 Receptor Blockers). 0 (Apelin). 0 (Biomarkers). 0 (Blood Glucose). 0 (Enzyme Inhibitors). 0 (Insulin). 31C4KY9ESH (Nitric Oxide). JMS50MPO89 (Losartan). V55S2QJN2X (NG-Nitroarginine Methyl Ester).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f13813455.2018.1453521
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sabry&issn=1381-3455&title=Archives+of+Physiology+%26+Biochemistry&atitle=Interactive+effects+of+apelin%2C+renin-angiotensin+system+and+nitric+oxide+in+treatment+of+obesity-induced+type+2+diabetes+mellitus+in+male+albino+rats.&volume=125&issue=3&spage=244&epage=254&date=2019&doi=10.1080%2F13813455.2018.1453521&pmid=29564917&sid=OVID:medline
+
+<1931>
+Unique Identifier
+ 29476244
+Title
+ Association of body mass index and waist circumference with osteocalcin and C-terminal telopeptide in Iranian elderly: results from a cross-sectional study.
+Source
+ Journal of Bone & Mineral Metabolism. 37(1):179-184, 2019 Jan.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kord-Varkaneh H; Tangestani H; Mansouri S; Rahimi-Foroushani A; Shab-Bidar S
+Authors Full Name
+ Kord-Varkaneh, Hamed; Tangestani, Hadith; Mansouri, Sara; Rahimi-Foroushani, Abbas; Shab-Bidar, Sakineh.
+Institution
+ Kord-Varkaneh, Hamed. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), No 44 Hojjat-dost Alley, Naderi St., Keshavarz Blvd, Tehran, Iran.
+ Tangestani, Hadith. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), No 44 Hojjat-dost Alley, Naderi St., Keshavarz Blvd, Tehran, Iran.
+ Mansouri, Sara. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), No 44 Hojjat-dost Alley, Naderi St., Keshavarz Blvd, Tehran, Iran.
+ Rahimi-Foroushani, Abbas. Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
+ Shab-Bidar, Sakineh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), No 44 Hojjat-dost Alley, Naderi St., Keshavarz Blvd, Tehran, Iran. s_shabbidar@tums.ac.ir.
+MeSH Subject Headings
+ Aged
+ Biomarkers/me [Metabolism]
+ *Body Mass Index
+ Bone and Bones/me [Metabolism]
+ C-Reactive Protein/me [Metabolism]
+ *Collagen Type I/me [Metabolism]
+ Cross-Sectional Studies
+ Female
+ Humans
+ Iran
+ Male
+ Obesity
+ *Osteocalcin/me [Metabolism]
+ *Peptides/me [Metabolism]
+ Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/me [Metabolism]
+ *Waist Circumference
+Keyword Heading
+ Bone marker
+ CTX-I
+ Elderly
+ Obesity
+ Osteocalcin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ There is no agreement on the role of obesity as a protection or unfavorable factor on bone. In the present study, the association of body mass index (BMI) and waist circumference (WC) with osteocalcin, C-terminal telopeptide of type 1 collagen (CTX-I), highly sensitive C-reactive protein (hs-CRP), parathormon (PTH) and 25-hydroxyvitamin D (25(OH)D) in elderly people was investigated. This cross-sectional study was conducted on 178 elderly residents in Tehran, with a mean age of 67.04 (60-83). Serum osteocalcin, hs-CRP, 25(OH) D, PTH and urine CTX-I were measured for all participants. Waist circumference, weight and height were measured and BMI was calculated. Linear regression and Pearson correlation were performed to evaluate the relation of BMI and waist circumference with other variables. A significant inverse association was found between BMI with osteocalcin (beta = - 0.171, p = 0.027) after control for covariates. In addition, there were a significant relation of BMI and WC with hs-CRP (beta = 0.246, p = 0.002 and beta = 0.219, p = 0.006, respectively) and PTH (beta = 0.1169, p = 0.040 and beta = 0.200, p = 0.018), respectively. The present study did not show a significant relation of BMI and WC with urine CTX-I even after adjustment for potential confounders (beta = - 0.143, p = 0.065 and beta = - 0.104, p = 0.183, respectively). The present study has concluded that obesity is an undesirable factor for bone metabolism by reducing serum osteocalcin and by increasing hs-CRP and PTH which contribute to bone resorption.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Collagen Type I). 0 (Peptides). 0 (collagen type I trimeric cross-linked peptide). 104982-03-8 (Osteocalcin). 1406-16-2 (Vitamin D). 9007-41-4 (C-Reactive Protein). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs00774-018-0912-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kord-Varkaneh&issn=0914-8779&title=Journal+of+Bone+%26+Mineral+Metabolism&atitle=Association+of+body+mass+index+and+waist+circumference+with+osteocalcin+and+C-terminal+telopeptide+in+Iranian+elderly%3A+results+from+a+cross-sectional+study.&volume=37&issue=1&spage=179&epage=184&date=2019&doi=10.1007%2Fs00774-018-0912-5&pmid=29476244&sid=OVID:medline
+
+<1932>
+Unique Identifier
+ 29438687
+Title
+ Increased ApoB/ApoA1 ratio is associated with excess weight, body adiposity, and altered lipid profile in children.
+Source
+ Jornal de Pediatria. 95(2):238-246, 2019 Mar - Apr.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Castro APP; Hermsdorff HHM; Milagres LC; Albuquerque FM; Filgueiras MS; Rocha NP; Novaes JF
+Authors Full Name
+ Castro, Ana Paula Pereira; Hermsdorff, Helen Hermana Miranda; Milagres, Luana Cupertino; Albuquerque, Fernanda Martins de; Filgueiras, Mariana de Santis; Rocha, Naruna Pereira; Novaes, Juliana Farias de.
+Institution
+ Castro, Ana Paula Pereira. Universidade Federal de Vicosa (UFV), Departamento de Nutricao e Saude, Vicosa, MG, Brazil. Electronic address: anaenut@gmail.com.
+ Hermsdorff, Helen Hermana Miranda. Universidade Federal de Vicosa (UFV), Departamento de Nutricao e Saude, Vicosa, MG, Brazil.
+ Milagres, Luana Cupertino. Universidade Federal de Vicosa (UFV), Departamento de Nutricao e Saude, Vicosa, MG, Brazil.
+ Albuquerque, Fernanda Martins de. Universidade Federal de Vicosa (UFV), Departamento de Nutricao e Saude, Vicosa, MG, Brazil.
+ Filgueiras, Mariana de Santis. Universidade Federal de Vicosa (UFV), Departamento de Nutricao e Saude, Vicosa, MG, Brazil.
+ Rocha, Naruna Pereira. Universidade Federal de Vicosa (UFV), Departamento de Nutricao e Saude, Vicosa, MG, Brazil.
+ Novaes, Juliana Farias de. Universidade Federal de Vicosa (UFV), Departamento de Nutricao e Saude, Vicosa, MG, Brazil.
+MeSH Subject Headings
+ Adiposity
+ *Apolipoprotein A-I/bl [Blood]
+ *Apolipoprotein B-100/bl [Blood]
+ *Arteriosclerosis/bl [Blood]
+ Arteriosclerosis/et [Etiology]
+ Biomarkers/bl [Blood]
+ Body Composition
+ Child
+ Cross-Sectional Studies
+ Female
+ Humans
+ *Lipids/bl [Blood]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Risk Factors
+ Sedentary Behavior
+ Socioeconomic Factors
+ Surveys and Questionnaires
+ Urban Population
+Keyword Heading
+ Adiposidade
+ Adiposity
+ Apolipoproteins
+ Apolipoproteinas
+ Children
+ Criancas
+ Dislipidemias
+ Dyslipidemias
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: To investigate ApoB/ApoA1 ratio and its association with cardiovascular risk factors in children.
+
+ METHODS: Cross-sectional study with 258 children aged 8 and 9 years old, enrolled in all urban schools in the city of Vicosa-MG. Anthropometric and body composition assessment, as well as biochemical profile of the children was performed. Socioeconomic variables and sedentary lifestyle were evaluated through a semi-structured questionnaire.
+
+ RESULTS: Many children had excess weight (35.2%), abdominal adiposity (10.5%), and body fat (15.6%), as well as increased ApoB/ApoA1 ratio (14.7%), total cholesterol (51.8%), and triglycerides (19.8%). Children with excess weight and total and central fat had a higher prevalence of having a higher ApoB/ApoA1 ratio, as well as those with atherogenic lipid profile (increased LDL-c and triglycerides and low HDL-c). A direct association was found between the number of cardiovascular risk factors and the ApoB/ApoA1 ratio (p=0.001), regardless of age and income.
+
+ CONCLUSION: The increased ApoB/ApoA1 ratio was associated with excess weight, body adiposity (total and central), and altered lipid profile in children. Children with a higher number of cardiovascular risk factors had higher ApoB/ApoA1 ratio, in both genders. Copyright © 2018 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
+Registry Number/Name of Substance
+ 0 (APOA1 protein, human). 0 (APOB protein, human). 0 (Apolipoprotein A-I). 0 (Apolipoprotein B-100). 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.jped.2017.12.008
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Castro&issn=0021-7557&title=Jornal+de+Pediatria&atitle=Increased+ApoB%2FApoA1+ratio+is+associated+with+excess+weight%2C+body+adiposity%2C+and+altered+lipid+profile+in+children.&volume=95&issue=2&spage=238&epage=246&date=2019&doi=10.1016%2Fj.jped.2017.12.008&pmid=29438687&sid=OVID:medline
+
+<1933>
+Unique Identifier
+ 29438496
+Title
+ The Adiponectin Paradox in the Elderly: Associations With Body Composition, Physical Functioning, and Mortality.
+Source
+ Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 74(2):247-253, 2019 01 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Baker JF; Newman AB; Kanaya A; Leonard MB; Zemel B; Miljkovic I; Long J; Weber D; Harris TB
+Authors Full Name
+ Baker, Joshua F; Newman, Anne B; Kanaya, Alka; Leonard, Mary B; Zemel, Babette; Miljkovic, Iva; Long, Jin; Weber, David; Harris, Tamara B.
+Institution
+ Baker, Joshua F. Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia.
+ Baker, Joshua F. University of Pennsylvania, School of Medicine, Philadelphia.
+ Baker, Joshua F. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia.
+ Newman, Anne B. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
+ Kanaya, Alka. Division of General Internal Medicine, University of California at San Francisco, San Francisco, California.
+ Leonard, Mary B. Department of Pediatrics and Medicine, Stanford University, Stanford.
+ Zemel, Babette. Children's Hospital of Philadelphia, Philadelphia.
+ Miljkovic, Iva. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
+ Long, Jin. Department of Pediatrics and Medicine, Stanford University, Stanford.
+ Weber, David. Division of Endocrinology and Diabetes, Golisano Children's Hospital, University of Rochester, Rochester.
+ Harris, Tamara B. Laboratory of Epidemiology and Population Sciences, Intramural Research Program, NIA, NIH, Bethesda, Maryl.
+MeSH Subject Headings
+ Absorptiometry, Photon/mt [Methods]
+ *Adiponectin/bl [Blood]
+ *Adiposity/ph [Physiology]
+ Aged
+ Biomarkers/bl [Blood]
+ *Body Composition/ph [Physiology]
+ Cause of Death/td [Trends]
+ *Exercise/ph [Physiology]
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/mo [Mortality]
+ Prospective Studies
+ *Risk Assessment
+ Risk Factors
+ Survival Rate/td [Trends]
+ United States/ep [Epidemiology]
+ Weight Loss
+Abstract
+ Background: To determine if adiponectin levels are associated with weight loss, low muscle mass, and physical functioning among the elderly and to determine independent associations with incident disability and death.
+
+ Methods: Included were 3,044 participants from the Health, Aging and Body Composition Study, who had whole-body dual energy absorptiometry performed to evaluate appendicular lean mass index (ALMI, kg/m2) and fat mass index (FMI, kg/m2), computed tomography measures of thigh muscle density, weight histories, estimates of physical functioning, and adiponectin levels at enrollment. Associations between adiponectin levels and body composition, weight loss, and physical functioning were assessed in multivariable linear regression models. Associations between adiponectin and incident disability and mortality were assessed in mediation analyses, adjusting for other factors.
+
+ Results: Greater adiponectin at baseline was independently associated with low FMI Z-score, lower waist circumference, low ALMI Z-score, low muscle density, a history of weight loss, and poor physical functioning (all p < .05). Greater adiponectin levels (per SD) were associated with incident disability [HR: 1.14 (1.08, 1.20), p < .001] and greater mortality [HR: 1.17 (1.10, 1.25), p < .001] in models adjusting for demographic factors, adiposity, and comorbid conditions. The association was completely attenuated and no longer significant (all p > 0.05) when adjusting for body composition, muscle density, weight loss, and physical functioning at baseline.
+
+ Conclusions: Greater serum adiponectin levels are associated with historical weight loss, low skeletal muscle mass, low muscle density, and poor physical functioning. High adiponectin is associated with a greater risk of incident disability and death, but not independently of these factors.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study. Observational Study. Research Support, N.I.H., Extramural. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fgerona%2fgly017
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Baker&issn=1079-5006&title=Journals+of+Gerontology+Series+A-Biological+Sciences+%26+Medical+Sciences&atitle=The+Adiponectin+Paradox+in+the+Elderly%3A+Associations+With+Body+Composition%2C+Physical+Functioning%2C+and+Mortality.&volume=74&issue=2&spage=247&epage=253&date=2019&doi=10.1093%2Fgerona%2Fgly017&pmid=29438496&sid=OVID:medline
+
+<1934>
+Unique Identifier
+ 29437487
+Title
+ Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance.
+Source
+ Archives of Physiology & Biochemistry. 125(1):79-84, 2019 Feb.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dallak M; Bin-Jaliah I; Sakr HF; Al-Ani B; Haidara MA
+Authors Full Name
+ Dallak, Mohammad; Bin-Jaliah, Ismaeel; Sakr, Hussein F; Al-Ani, Bahjat; Haidara, Mohamed A.
+Institution
+ Dallak, Mohammad. a Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
+ Bin-Jaliah, Ismaeel. a Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
+ Sakr, Hussein F. b Department of Medical Physiology, Faculty of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
+ Al-Ani, Bahjat. a Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
+ Haidara, Mohamed A. a Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
+ Haidara, Mohamed A. c Department of Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ *Blood Coagulation
+ Disease Models, Animal
+ Hyperlipidemias/co [Complications]
+ *Insulin Resistance
+ Male
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ *Physical Conditioning, Animal
+ Rats
+ Rats, Wistar
+ *Swimming
+ Thrombosis/co [Complications]
+Keyword Heading
+ Obesity
+ coagulation
+ exercise
+ insulin resistance
+ rat model
+ thrombosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis.
+
+ MATERIAL AND METHODS: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-'treated' rats started swim exercise training from the 11th week until being sacrificed, on Week 15.
+
+ RESULTS: HCFD caused a significant increase in blood glucose, insulin resistance (HOMA-IR), lipidemia, and inflammatory biomarkers. In addition, HCFD significantly modulated coagulation and thrombosis biomarkers; fibrinogen, plasminogen activator inhibitor-1, von Willebrand factor, prothrombin time, activated partial thromboplastin time, blood clotting and bleeding time, and ADP-induced platelet aggregation that was effectively inhibited by swimming exercises.
+
+ CONCLUSIONS: We demonstrate that in an animal model of obesity and insulin resistance, there is a significant change in hemostasis, which is ameliorated by swim exercise.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f13813455.2018.1437749
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dallak&issn=1381-3455&title=Archives+of+Physiology+%26+Biochemistry&atitle=Swim+exercise+inhibits+hemostatic+abnormalities+in+a+rat+model+of+obesity+and+insulin+resistance.&volume=125&issue=1&spage=79&epage=84&date=2019&doi=10.1080%2F13813455.2018.1437749&pmid=29437487&sid=OVID:medline
+
+<1935>
+Unique Identifier
+ 29395813
+Title
+ Ghrelin concentration as an indicator of eating-disorder risk in obese women.
+Source
+ Diabetes & Metabolism. 45(2):160-166, 2019 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Iceta S; Julien B; Seyssel K; Lambert-Porcheron S; Segrestin B; Blond E; Cristini P; Laville M; Disse E
+Authors Full Name
+ Iceta, S; Julien, B; Seyssel, K; Lambert-Porcheron, S; Segrestin, B; Blond, E; Cristini, P; Laville, M; Disse, E.
+Institution
+ Iceta, S. Centre referent pour l'anorexie et les troubles du comportement alimentaire (CREATyon), hospices civils de Lyon, 69500 Bron, France; Inserm U1028, CNRS UMR 5292, equipe PSYR(2), Centre de recherche en neurosciences de Lyon (CRNL), centre hospitalier Le Vinatier, universite Claude-Bernard-Lyon 1, 69500 Bron, France; Centre integre de l'obesite Rhone-Alpes, federation hospitalo-universitaire DO-iT, service d'endocrinologie et nutrition, groupement hospitalier Sud, hospices civils de Lyon, 69310 Pierre-Benite, France. Electronic address: sylvain.iceta@chu-lyon.fr.
+ Julien, B. Unite Inserm U1060, Inra 1235, Insa-Lyon, centre de recherche en nutrition humaine Rhone-Alpes (CRNH-RA), centre europeen nutrition et sante (CENS), laboratoire CarMeN, universite Claude-Bernard-Lyon 1, 69310 Pierre-Benite, France.
+ Seyssel, K. Unite Inserm U1060, Inra 1235, Insa-Lyon, centre de recherche en nutrition humaine Rhone-Alpes (CRNH-RA), centre europeen nutrition et sante (CENS), laboratoire CarMeN, universite Claude-Bernard-Lyon 1, 69310 Pierre-Benite, France.
+ Lambert-Porcheron, S. Unite Inserm U1060, Inra 1235, Insa-Lyon, centre de recherche en nutrition humaine Rhone-Alpes (CRNH-RA), centre europeen nutrition et sante (CENS), laboratoire CarMeN, universite Claude-Bernard-Lyon 1, 69310 Pierre-Benite, France.
+ Segrestin, B. Centre referent pour l'anorexie et les troubles du comportement alimentaire (CREATyon), hospices civils de Lyon, 69500 Bron, France; Unite Inserm U1060, Inra 1235, Insa-Lyon, centre de recherche en nutrition humaine Rhone-Alpes (CRNH-RA), centre europeen nutrition et sante (CENS), laboratoire CarMeN, universite Claude-Bernard-Lyon 1, 69310 Pierre-Benite, France.
+ Blond, E. Service de biologie Sud, groupement hospitalier Sud, hospices civils de Lyon, Lyon, France.
+ Cristini, P. Centre integre de l'obesite Rhone-Alpes, federation hospitalo-universitaire DO-iT, service d'endocrinologie et nutrition, groupement hospitalier Sud, hospices civils de Lyon, 69310 Pierre-Benite, France.
+ Laville, M. Unite Inserm U1060, Inra 1235, Insa-Lyon, centre de recherche en nutrition humaine Rhone-Alpes (CRNH-RA), centre europeen nutrition et sante (CENS), laboratoire CarMeN, universite Claude-Bernard-Lyon 1, 69310 Pierre-Benite, France; Centre integre de l'obesite Rhone-Alpes, federation hospitalo-universitaire DO-iT, service d'endocrinologie et nutrition, groupement hospitalier Sud, hospices civils de Lyon, 69310 Pierre-Benite, France.
+ Disse, E. Unite Inserm U1060, Inra 1235, Insa-Lyon, centre de recherche en nutrition humaine Rhone-Alpes (CRNH-RA), centre europeen nutrition et sante (CENS), laboratoire CarMeN, universite Claude-Bernard-Lyon 1, 69310 Pierre-Benite, France; Centre integre de l'obesite Rhone-Alpes, federation hospitalo-universitaire DO-iT, service d'endocrinologie et nutrition, groupement hospitalier Sud, hospices civils de Lyon, 69310 Pierre-Benite, France.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Fasting/bl [Blood]
+ Feeding Behavior/ph [Physiology]
+ Feeding Behavior/px [Psychology]
+ *Feeding and Eating Disorders/bl [Blood]
+ Feeding and Eating Disorders/co [Complications]
+ *Feeding and Eating Disorders/di [Diagnosis]
+ Feeding and Eating Disorders/px [Psychology]
+ Female
+ *Ghrelin/bl [Blood]
+ Humans
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/px [Psychology]
+ Risk Factors
+ Surveys and Questionnaires
+ Young Adult
+Keyword Heading
+ Drive for thinness
+ Eating disorders
+ Ghrelin
+ Impulsive behaviour
+ Obesity
+ Vulnerability
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: Eating disorders (EDs), disordered eating (DE) and obesity are thought to have overlapping aetiological processes. DE in obesity can jeopardize weight-loss results, and acyl ghrelin (AG) is a hormone that stimulates food intake and reward processes. The main study objective was to determine whether higher-than-expected concentrations of AG in common obesity are associated with DE symptoms.
+
+ METHODS: The study population included 84 women, aged 20-55 years, free of established EDs: 55 were severely obese (OB) and 29 were of normal weight (NW). OB participants were stratified into two groups according to their median concentration of fasting AG distribution. The OB women with a high fasting plasma ghrelin concentration (HGC) were compared with both OB women with a low fasting plasma ghrelin concentration (LGC) and NW women. Participants were assessed by the Eating Disorder Inventory (EDI-2), Three-Factor Eating Questionnaire (TFEQ) and Hospital Anxiety and Depression Scale (HADS). Fasting glucose, insulin, leptin and ghrelin plasma concentrations were also quantified.
+
+ RESULTS: Between the two AG groups of OB women, there was no statistical difference in either anthropometric or metabolic parameters, HADS, TFEQ or fasting hunger scores. However, the HGC group scored significantly higher than the LGC group on the drive-for-thinness subscale of EDI-2 (9.30+/-0.99 vs. 6.46+/-0.83, respectively; P=0.033).
+
+ CONCLUSION: Results support the hypothesis of a potential relationship between fasting plasma AG concentrations and ED risk, regardless of mood and anxiety. AG may be considered a potential biomarker of vulnerability for developing EDs. Copyright © 2018 Elsevier Masson SAS. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ghrelin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.diabet.2018.01.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Iceta&issn=1262-3636&title=Diabetes+%26+Metabolism&atitle=Ghrelin+concentration+as+an+indicator+of+eating-disorder+risk+in+obese+women.&volume=45&issue=2&spage=160&epage=166&date=2019&doi=10.1016%2Fj.diabet.2018.01.006&pmid=29395813&sid=OVID:medline
+
+<1936>
+Unique Identifier
+ 29291899
+Title
+ Body mass index as a biomarker for the evaluation of the "Obesity Paradox" among inpatients.
+Source
+ Clinical Nutrition. 38(1):412-421, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tojek K; Wustrau B; Czerniak B; Korzycka-Wilinska W; Winiarski P; Banaszkiewicz Z; Budzynski J
+Authors Full Name
+ Tojek, Krzysztof; Wustrau, Beata; Czerniak, Beata; Korzycka-Wilinska, Wanda; Winiarski, Piotr; Banaszkiewicz, Zbigniew; Budzynski, Jacek.
+Institution
+ Tojek, Krzysztof. Department of General, Gastrointestinal, Colorectal and Oncological Surgery, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
+ Wustrau, Beata. Department of Vascular and Internal Diseases, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
+ Czerniak, Beata. Department of Vascular and Internal Diseases, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
+ Korzycka-Wilinska, Wanda. University Chair of Public Health, Department of Health Policy and Social Support, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
+ Winiarski, Piotr. Clinic of Phoniatry and Audiology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland; Department of Otolaryngology and Laryngeal Oncology with Division of Maxillomandibular Surgery, Jan Biziel University Hospital No. 2 in Bydgoszcz, Poland.
+ Banaszkiewicz, Zbigniew. Department of General, Gastrointestinal, Colorectal and Oncological Surgery, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
+ Budzynski, Jacek. Department of Vascular and Internal Diseases, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland. Electronic address: budz@cps.pl.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Aged
+ Biomarkers
+ *Body Mass Index
+ Female
+ Follow-Up Studies
+ Hospital Mortality
+ Humans
+ *Inpatients/sn [Statistics & Numerical Data]
+ Length of Stay/sn [Statistics & Numerical Data]
+ Male
+ *Malnutrition/ep [Epidemiology]
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ Patient Readmission/sn [Statistics & Numerical Data]
+ Poland/ep [Epidemiology]
+Keyword Heading
+ All-cause mortality
+ Body mass index
+ Hospitalized patients
+ Older adults
+ Prognosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Overweight and obesity are, on the one hand, recognized as risk factors for many health-related disorders, and, on the other, as favorable prognostic factors in various patients treated for several different conditions; what is called the "obesity paradox". Until now, the existence of this phenomenon among a general population of consecutive inpatients has not been evaluated. We decided, therefore, to perform an evaluation.
+
+ PATIENTS AND METHODS: Historical prospective analysis of the medical documentation of 23 603 hospitalizations during two consecutive years in one center was performed. The outcomes measured were as follows: length of stay, in-hospital all-cause mortality, and non-scheduled readmission in the 14-day, 30-day and one-year periods following discharge.
+
+ RESULTS: Overweight and obese patients had a lower or similar prevalence of the measured outcomes than malnourished patients and those of normal weight. Adjustment of the standard WHO BMI ranges for patients aged >=65 y (normal weight BMI range 23-33 kg/m2) made these differences more apparent. In logistic regression, the ratio of fat to fat-free body mass was a stronger and unfavorable risk factor compared with BMI for the measured outcomes.
+
+ CONCLUSIONS: The greatest risk of all-cause in-hospital death and readmission concerned malnourished inpatients. Compared to patients with a normal BMI range, overweight and obesity had a lower or similar (but not greater) risk of the outcomes measured. However, due to several BMI limitations, our observations should be interpreted as suggesting a "BMI paradox", rather than an "obesity paradox". Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.clnu.2017.12.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tojek&issn=0261-5614&title=Clinical+Nutrition&atitle=Body+mass+index+as+a+biomarker+for+the+evaluation+of+the+%22Obesity+Paradox%22+among+inpatients.&volume=38&issue=1&spage=412&epage=421&date=2019&doi=10.1016%2Fj.clnu.2017.12.005&pmid=29291899&sid=OVID:medline
+
+<1937>
+Unique Identifier
+ 29079305
+Title
+ KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops. [Review]
+Source
+ Seminars in Cancer Biology. 54:50-62, 2019 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Eibl G; Rozengurt E
+Authors Full Name
+ Eibl, Guido; Rozengurt, Enrique.
+Institution
+ Eibl, Guido. Departments of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; CURE: Digestive Diseases Research Center, University of California at Los Angeles, Los Angeles, CA, United States. Electronic address: Geibl@mednet.ucla.edu.
+ Rozengurt, Enrique. Departments of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; CURE: Digestive Diseases Research Center, University of California at Los Angeles, Los Angeles, CA, United States.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Carcinoma, Pancreatic Ductal/et [Etiology]
+ Carcinoma, Pancreatic Ductal/me [Metabolism]
+ Carcinoma, Pancreatic Ductal/pa [Pathology]
+ Cell Cycle Proteins
+ Chemoprevention
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Disease Models, Animal
+ Gene Expression Regulation, Neoplastic/de [Drug Effects]
+ Hippo Signaling Pathway
+ Humans
+ Mutation
+ Nuclear Proteins/ge [Genetics]
+ *Nuclear Proteins/me [Metabolism]
+ *Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ *Pancreatic Neoplasms/et [Etiology]
+ *Pancreatic Neoplasms/me [Metabolism]
+ Pancreatic Neoplasms/pa [Pathology]
+ Pancreatic Neoplasms/pc [Prevention & Control]
+ Protein Serine-Threonine Kinases/ge [Genetics]
+ Protein Serine-Threonine Kinases/me [Metabolism]
+ Proto-Oncogene Proteins p21(ras)/ge [Genetics]
+ *Proto-Oncogene Proteins p21(ras)/me [Metabolism]
+ Risk Factors
+ Signal Transduction/de [Drug Effects]
+ *Signal Transduction
+ Transcription Factors/ge [Genetics]
+ *Transcription Factors/me [Metabolism]
+Keyword Heading
+ Obesity
+ Oncogenic kras
+ Pancreatic cancer
+ Signaling network
+ YAP
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pancreatic ductal adenocarcinoma (PDAC) continues to be a lethal disease with no efficacious treatment modalities. The incidence of PDAC is expected to increase, at least partially because of the obesity epidemic. Increased efforts to prevent or intercept this disease are clearly needed. Mutations in KRAS are initiating events in pancreatic carcinogenesis supported by genetically engineered mouse models of the disease. However, oncogenic KRAS is not entirely sufficient for the development of fully invasive PDAC. Additional genetic mutations and/or environmental, nutritional, and metabolic stressors, e.g. inflammation and obesity, are required for efficient PDAC formation with activation of KRAS downstream effectors. Multiple factors "upstream" of KRAS associated with obesity, including insulin resistance, inflammation, changes in gut microbiota and GI peptides, can enhance/modulate downstream signals. Multiple signaling networks and feedback loops "downstream" of KRAS have been described that respond to obesogenic diets. We propose that KRAS mutations potentiate a signaling network that is promoted by environmental factors. Specifically, we envisage that KRAS mutations increase the intensity and duration of the growth-promoting signaling network. As the transcriptional activator YAP plays a critical role in the network, we conclude that the rationale for targeting the network (at different points), e.g. with FDA approved drugs such as statins and metformin, is therefore compelling. Copyright © 2017 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cell Cycle Proteins). 0 (KRAS protein, human). 0 (Nuclear Proteins). 0 (Transcription Factors). 0 (YY1AP1 protein, human). EC 2-7-11-1 (Protein Serine-Threonine Kinases). EC 3-6-5-2 (Proto-Oncogene Proteins p21(ras)).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S.. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.semcancer.2017.10.007
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Eibl&issn=1044-579X&title=Seminars+in+Cancer+Biology&atitle=KRAS%2C+YAP%2C+and+obesity+in+pancreatic+cancer%3A+A+signaling+network+with+multiple+loops.&volume=54&issue=&spage=50&epage=62&date=2019&doi=10.1016%2Fj.semcancer.2017.10.007&pmid=29079305&sid=OVID:medline
+
+<1938>
+Unique Identifier
+ 28718392
+Title
+ Efficient body fat estimation using multistage pair ranked set sampling.
+Source
+ Statistical Methods in Medical Research. 28(1):223-234, 2019 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mahdizadeh M; Zamanzade E
+Authors Full Name
+ Mahdizadeh, M; Zamanzade, Ehsan.
+Institution
+ Mahdizadeh, M. 1 Department of Statistics, Hakim Sabzevari University, Sabzevar, Iran.
+ Zamanzade, Ehsan. 2 Department of Statistics, University of Isfahan, Isfahan, Iran.
+MeSH Subject Headings
+ Absorptiometry, Photon
+ *Adipose Tissue
+ Biomarkers
+ Humans
+ Models, Statistical
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Overweight/di [Diagnosis]
+ Overweight/ep [Epidemiology]
+ *Sampling Studies
+ Waist Circumference
+Keyword Heading
+ Auxiliary information
+ concomitant variable
+ judgment ranking
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Rank-based sampling methods are applicable in settings where precise measurements are expensive, but small sets of units can be accurately ranked at negligible cost. This article introduces one such a design, called multistage pair ranked set sampling. It mitigates ranking burden associated with a competitor scheme, namely multistage ranked set sampling. The mean estimator in multistage pair ranked set sampling is unbiased, and under perfect rankings has variance no larger than its simple random sampling counterpart. Although the suggested mean estimator is outperformed by its multistage ranked set sampling analog in terms of precision under perfect rankings, the situation may be reversed if cost considerations are taken into account. The methodology is illustrated using a medical dataset.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1177%2f0962280217720473
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mahdizadeh&issn=0962-2802&title=Statistical+Methods+in+Medical+Research&atitle=Efficient+body+fat+estimation+using+multistage+pair+ranked+set+sampling.&volume=28&issue=1&spage=223&epage=234&date=2019&doi=10.1177%2F0962280217720473&pmid=28718392&sid=OVID:medline
+
+<1939>
+Unique Identifier
+ 32743649
+Title
+ Intraindividual double burden of overweight or obesity and micronutrient deficiencies or anemia among women of reproductive age in 17 population-based surveys.
+Source
+ American Journal of Clinical Nutrition. 112(Suppl 1):468S-477S, 2019 08 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Williams AM; Guo J; Addo OY; Ismaily S; Namaste SML; Oaks BM; Rohner F; Suchdev PS; Young MF; Flores-Ayala R; Engle-Stone R
+Authors Full Name
+ Williams, Anne M; Guo, Junjie; Addo, O Yaw; Ismaily, Sanober; Namaste, Sorrel M L; Oaks, Brietta M; Rohner, Fabian; Suchdev, Parminder S; Young, Melissa F; Flores-Ayala, Rafael; Engle-Stone, Reina.
+Institution
+ Williams, Anne M. Hubert Department of Global Health, Emory University, Atlanta, GA, USA.
+ Williams, Anne M. McKing Consulting Corporation, Atlanta, GA, USA.
+ Guo, Junjie. Hubert Department of Global Health, Emory University, Atlanta, GA, USA.
+ Addo, O Yaw. Hubert Department of Global Health, Emory University, Atlanta, GA, USA.
+ Addo, O Yaw. McKing Consulting Corporation, Atlanta, GA, USA.
+ Ismaily, Sanober. Hubert Department of Global Health, Emory University, Atlanta, GA, USA.
+ Namaste, Sorrel M L. The DHS Program, ICF International, Rockville, MD, USA.
+ Oaks, Brietta M. Department of Nutrition and Food Sciences, University of Rhode Island, Kingston, RI, USA.
+ Rohner, Fabian. GroundWork, Flasch, Switzerland.
+ Suchdev, Parminder S. Department of Pediatrics, Emory University, Atlanta, GA, USA.
+ Suchdev, Parminder S. Emory Global Health Institute, Atlanta, GA, USA.
+ Suchdev, Parminder S. Division of Nutrition, Physical Activity and Obesity, US CDC, Atlanta, GA, USA.
+ Young, Melissa F. Hubert Department of Global Health, Emory University, Atlanta, GA, USA.
+ Flores-Ayala, Rafael. Division of Nutrition, Physical Activity and Obesity, US CDC, Atlanta, GA, USA.
+ Engle-Stone, Reina. Department of Nutrition, University of California, Davis, CA, USA.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Age Factors
+ Anemia/bl [Blood]
+ *Anemia/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ *Body Mass Index
+ Comorbidity
+ Deficiency Diseases/bl [Blood]
+ *Deficiency Diseases/ep [Epidemiology]
+ Female
+ Global Health
+ Humans
+ Income
+ Logistic Models
+ *Micronutrients/bl [Blood]
+ *Nutritional Status
+ *Obesity/ep [Epidemiology]
+ Overweight/ep [Epidemiology]
+ Poverty
+ Prevalence
+ Social Class
+ Surveys and Questionnaires
+ Young Adult
+Keyword Heading
+ anemia
+ double burden of malnutrition
+ micronutrients
+ overweight/obesity
+ women
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Rising prevalence of overweight/obesity (OWOB) alongside persistent micronutrient deficiencies suggests many women face concomitant OWOB and undernutrition.
+
+ OBJECTIVES: We aimed to 1) describe the prevalence of the double burden of malnutrition (DBM) among nonpregnant women of reproductive age, defined as intraindividual OWOB and either >=1 micronutrient deficiency [micronutrient deficiency index (MDI) > 0; DBM-MDI] or anemia (DBM-anemia); 2) test whether the components of the DBM were independent; and 3) identify factors associated with DBM-MDI and DBM-anemia.
+
+ METHODS: With data from 17 national surveys spanning low- and middle-income countries (LMICs) and high-income countries from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia project (n = 419 to n = 9029), we tested independence of over- and undernutrition using the Rao-Scott chi-square test and examined predictors of the DBM and its components using logistic regression for each survey.
+
+ RESULTS: Median DBM-MDI was 21.9% (range: 1.6%-39.2%); median DBM-anemia was 8.6% (range: 1.0%-18.6%). OWOB and micronutrient deficiencies or anemia were independent in most surveys. Where associations existed, OWOB was negatively associated with micronutrient deficiencies and anemia in LMICs. In 1 high-income country, OWOB women were more likely to experience micronutrient deficiencies and anemia. Age was consistently positively associated with OWOB and the DBM, whereas the associations with other sociodemographic characteristics varied. Higher socioeconomic status tended to be positively associated with OWOB and the DBM in LMICs, whereas in higher-income countries the association was reversed.
+
+ CONCLUSIONS: The independence of OWOB and micronutrient deficiencies or anemia within individuals suggests that these forms of over- and undernutrition may have unique etiologies. Decision-makers should still consider the prevalence, consequences, and etiology of the individual components of the DBM as programs move towards double-duty interventions aimed at addressing OWOB and undernutrition simultaneously. Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Micronutrients).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1093%2fajcn%2fnqaa118
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Williams&issn=0002-9165&title=American+Journal+of+Clinical+Nutrition&atitle=Intraindividual+double+burden+of+overweight+or+obesity+and+micronutrient+deficiencies+or+anemia+among+women+of+reproductive+age+in+17+population-based+surveys.&volume=112&issue=1&spage=468S&epage=477S&date=2019&doi=10.1093%2Fajcn%2Fnqaa118&pmid=32743649&sid=OVID:medline
+
+<1940>
+Unique Identifier
+ 32270970
+Title
+ Relation of carbohydrate exchange markers with vitamin D status in adolescents with overweight and obesity.
+Original Title
+ Korelacja markerow przemiany weglowodanow ze stezeniem witaminy D u nastolatkow z nadwaga i otyloscia.
+Source
+ Pediatric endocrinology, diabetes, & metabolism. 25(4):169-176, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Shulhai AM; Pavlyshyn H; Shulhai O
+Authors Full Name
+ Shulhai, Anna-Mariia; Pavlyshyn, Halyna; Shulhai, Oleksandra.
+Institution
+ Shulhai, Anna-Mariia. Department of Pediatrics No2, I. Horbachevsky Ternopil National Medical University, Ukraine.
+ Pavlyshyn, Halyna. Department of Pediatrics No2, I. Horbachevsky Ternopil National Medical University, Ukraine.
+ Shulhai, Oleksandra. Department of Children's Diseases with Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ukraine.
+MeSH Subject Headings
+ Adolescent
+ Biomarkers/bl [Blood]
+ Blood Glucose
+ Body Mass Index
+ Female
+ Glucose/me [Metabolism]
+ Humans
+ *Insulin/bl [Blood]
+ Insulin Resistance
+ Male
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Overweight/bl [Blood]
+ Overweight/co [Complications]
+ Vitamin D/bl [Blood]
+ Vitamin D Deficiency/bl [Blood]
+ *Vitamin D Deficiency/et [Etiology]
+ Waist Circumference
+Keyword Heading
+ adolescent
+ carbohydrate metabolism
+ vitamin D
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: In the case of obesity and excessive body weight, the deficiency of vitamin D increases, which significantly impairs metabolic processes in the body, especially fatty and carbohydrate metabolism. Vitamin D metabolites affect insulin sensitivity of cells.
+
+ THE AIM OF THE STUDY: was to determine the relationship between vitamin D and carbohydrate metabolism in adolescents with excessive body weight and obesi-ty.
+
+ MATERIAL AND METHODS: 139 adolescents were examined. The mean age of children was 15.5 +/-2.3 years. 65 adolescents with excessive weight and 74 obesity teenagers were examined. Parameters that were determined in all children included: undertaking anthropometric measurements, general examinations, biochemical parameters, including carbohydrate metabolism: fasting glucose, insulin, oral glucose tolerant test, measuring the homeostasis model assessment for insulin resistance, blood pressure measurement and determination of vitamin D status.
+
+ RESULTS: The features of changes carbohydrate metabolism markers in adolescents with overweight and obesity, depending on the level of serum 25(OH)D, have been established. Correlations between vitamin D status and markers of carbohydrate metabolism such as basal insulin level (p = 0.000) and HOMA-IR index (p = 0.000) and anthropometric indices: body mass index (p = 0.000), waist circumference (p = 0.000) and hip circumference (p = 0.001), waist-hip ratio (p = 0.000), waist-to-height ratio (p = 0.000) have been determined.
+
+ CONCLUSIONS: The study has established prognostically significant biochemical (basal insulin), and anthropometric (body mass index, waist circumfer-ence, waist-hip ratio, and waist-to-height ratio) markers resulting in vitamin D deficiency development in children with excessive body weight and obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 1406-16-2 (Vitamin D). IY9XDZ35W2 (Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.5114%2fpedm.2019.89640
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Shulhai&issn=2083-8441&title=Pediatric+endocrinology%2C+diabetes%2C+%26+metabolism&atitle=Korelacja+markerow+przemiany+weglowodanow+ze+stezeniem+witaminy+D+u+nastolatkow+z+nadwaga+i+otyloscia.&volume=25&issue=4&spage=169&epage=176&date=2019&doi=10.5114%2Fpedm.2019.89640&pmid=32270970&sid=OVID:medline
+
+<1941>
+Unique Identifier
+ 32127864
+Title
+ Impact of aerobic versus resisted exercise training on systemic inflammation biomarkers and quality of Life among obese post-menopausal women.
+Source
+ African Health Sciences. 19(4):2881-2891, 2019 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abd El-Kader SM; Al-Jiffri OH
+Authors Full Name
+ Abd El-Kader, Shehab M; Al-Jiffri, Osama H.
+Institution
+ Abd El-Kader, Shehab M. Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+ Al-Jiffri, Osama H. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Cytokines/bl [Blood]
+ *Exercise/ph [Physiology]
+ Female
+ Humans
+ *Inflammation/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ *Postmenopause
+ *Quality of Life
+ Treatment Outcome
+Keyword Heading
+ Aerobic exercise
+ inflammatory cytokine
+ menopause
+ obesity
+ quality of life
+ resisted exercises
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Although post-menopausal obesity is an important public national health problem in Saudi Arabia, to date no study has evaluated the effects of weight reduction on biochemical & clinical parameters and quality of Life for obese Saudi post-menopausal women.
+
+ OBJECTIVE: The aim of this study was examine the effects of aerobic versus resisted exercise training effects upon systemic inflammation biomarkers and quality of life for obese post-menopausal Saudi women.
+
+ MATERIAL AND METHODS: One hundred Saudi post-menopausal obese women participated in this study, their age ranged from 50-58 years and their body mass index (BMI) ranged from 30-35 kg/m2. All participants were divided into two equal groups: The first group received aerobic exercise training on treadmill where, the second group received resisted exercise training. Health-related quality of life (SF-36 HRQL), tumor necrosis factor- alpha(TNF-alpha), Interleukin-2(IL-2), Interleukin-4 (IL-4), Interleukin-6 (IL-6) and C-reactive protein (CRP) were measured before and after 3 months at the end of the study.
+
+ RESULTS: The mean values of SF-36 HRQL subscale scores were significantly increased, while the mean value of TNF-alpha, Il-2, IL-4, IL-6, CRP and BMI were significantly decreased in both groups after treatments. There were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment with more changes in patients received aerobic exercise training.
+
+ CONCLUSION: The current study provides evidence that aerobic exercise is more appropriate than resisted exercise training in modulating inflammatory cytokines and quality of life among obese post-menopausal women. Copyright © 2019 Abd El-Kader et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.4314%2fahs.v19i4.10
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abd+El-Kader&issn=1680-6905&title=African+Health+Sciences&atitle=Impact+of+aerobic+versus+resisted+exercise+training+on+systemic+inflammation+biomarkers+and+quality+of+Life+among+obese+post-menopausal+women.&volume=19&issue=4&spage=2881&epage=2891&date=2019&doi=10.4314%2Fahs.v19i4.10&pmid=32127864&sid=OVID:medline
+
+<1942>
+Unique Identifier
+ 32038642
+Title
+ The Interplay Between Tissue Niche and Macrophage Cellular Metabolism in Obesity. [Review]
+Source
+ Frontiers in Immunology. 10:3133, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Daemen S; Schilling JD
+Authors Full Name
+ Daemen, Sabine; Schilling, Joel D.
+Institution
+ Daemen, Sabine. Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
+ Schilling, Joel D. Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
+ Schilling, Joel D. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ *Cellular Microenvironment
+ Disease Susceptibility
+ *Energy Metabolism
+ Humans
+ Liver/me [Metabolism]
+ *Macrophages/cy [Cytology]
+ *Macrophages/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *Signal Transduction
+Keyword Heading
+ adipose tissue
+ insulin resistance
+ liver
+ macrophages
+ metabolism
+ non-alcoholic fatty liver disease
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with the development of metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease. The presence of chronic, low-grade inflammation appears to be an important mechanistic link between excess nutrients and clinical disease. The onset of these metabolic disorders coincides with changes in the number and phenotype of macrophages in peripheral organs, particularly in the liver and adipose tissue. Macrophage accumulation in these tissues has been implicated in tissue inflammation and fibrosis, contributing to metabolic disease progression. Recently, the concept has emerged that changes in macrophage metabolism affects their functional phenotype, possibly triggered by distinct environmental metabolic cues. This may be of particular importance in the setting of obesity, where both liver and adipose tissue are faced with a high metabolic burden. In the first part of this review we will discuss current knowledge regarding macrophage dynamics in both adipose tissue and liver in obesity. Then in the second part, we will highlight data linking macrophage metabolism to functional phenotype with an emphasis on macrophage activation in metabolic disease. The importance of understanding how tissue niche influences macrophage function in obesity will be highlighted. In addition, we will identify important knowledge gaps and outstanding questions that are relevant for future research in this area and will facilitate the identification of novel targets for therapeutic intervention in associated metabolic diseases. Copyright © 2020 Daemen and Schilling.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3389%2ffimmu.2019.03133
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Daemen&issn=1664-3224&title=Frontiers+in+Immunology&atitle=The+Interplay+Between+Tissue+Niche+and+Macrophage+Cellular+Metabolism+in+Obesity.&volume=10&issue=&spage=3133&epage=&date=2019&doi=10.3389%2Ffimmu.2019.03133&pmid=32038642&sid=OVID:medline
+
+<1943>
+Unique Identifier
+ 31965843
+Title
+ Mining possible associations of faecal A. muciniphila colonisation patterns with host adiposity and cardiometabolic markers in an adult population.
+Source
+ Beneficial Microbes. 10(7):741-749, 2019 Oct 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Mitsou EK; Detopoulou M; Kakali A; Fragopoulou E; Nomikos T; Antonopoulou S; Panagiotakos DB; Kyriacou A
+Authors Full Name
+ Mitsou, E K; Detopoulou, M; Kakali, A; Fragopoulou, E; Nomikos, T; Antonopoulou, S; Panagiotakos, D B; Kyriacou, A.
+Institution
+ Mitsou, E K. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.
+ Detopoulou, M. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.
+ Kakali, A. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.
+ Fragopoulou, E. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.
+ Nomikos, T. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.
+ Antonopoulou, S. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.
+ Panagiotakos, D B. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.
+ Kyriacou, A. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.
+MeSH Subject Headings
+ Adiponectin/bl [Blood]
+ *Adiposity
+ Adolescent
+ Adult
+ Aged
+ Akkermansia
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/an [Analysis]
+ *Cardiovascular Diseases/bl [Blood]
+ *Feces/mi [Microbiology]
+ Female
+ Gastrointestinal Microbiome
+ Greece
+ Host Microbial Interactions
+ Humans
+ Inflammation/bl [Blood]
+ Interleukin-10/bl [Blood]
+ Interleukin-6/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Overweight/co [Complications]
+ Urban Population
+ *Verrucomicrobia/ph [Physiology]
+ Young Adult
+Keyword Heading
+ gut microbiota
+ inflammation
+ metabolic health
+ obesity
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ We aimed to evaluate colonisation patterns of Akkermansia muciniphila in a Greek adult population and to investigate model-adjusted associations of A. muciniphila with host adiposity and cardiometabolic markers. Participants (n=125) underwent anthropometric, dietary, physical activity and lifestyle evaluation. Blood sampling for determination of blood lipid indices, glucose metabolism, adiponectin, lipoprotein-associated phospholipase A2 (Lp-PLA2), inflammation and oxidative stress parameters was also performed. Stool A. muciniphila presence and levels were determined by quantitative PCR and subjects were grouped based on bimodal distribution of levels (Low vs High). A. muciniphila was detected in 88.6% of participants. Overweight/obese (OW/OB) subjects were more prone in low bimodal levels of A. muciniphila compared to normal-weight (NW) individuals (58.75 vs 27.59%, P=0.004), with a 4-time greater likelihood after multi-adjusted logistic regression analysis (P=0.016). Levels of A. muciniphila were negatively associated with total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) ratio (log10:-0.009+/-0.004, P=0.033), whereas detection of this bacterium was negatively associated with both TC/HDL-C ratio (log10: -0.049+/-0.023, P=0.036) and low-density lipoprotein cholesterol/HDL-C ratio (-0.407+/-0.176, P=0.023). Furthermore, low bimodal levels of A. muciniphila were positively associated with fasting blood glucose (log10: 0.018+/-0.009, P=0.037). In terms of inflammation markers, levels of A. muciniphila were positively associated with soluble cluster of differentiation-14 (sCD14) (log10: 0.012+/-0.004, P=0.003) and faecal detection of this bacterium had a positive association with anti-inflammatory interleukin 10 levels (log10: 0.325+/-0.131, P=0.015). In addition, A. muciniphila levels were positively associated with total adiponectin (log10: 0.046+/-0.015, P=0.002), whereas low bimodal levels of A. muciniphila had an inverse relationship with this blood marker (log10: -0.131+/-0.053, P=0.016). In conclusion, we confirmed the previously reported association of A. muciniphila with metabolic health for the first time in a Greek urban population; furthermore, we shed some light to novel atherosclerotic risk markers with rather unexplored connections with A. muciniphila colonisation patterns in human subjects.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (IL10 protein, human). 0 (IL6 protein, human). 0 (Interleukin-6). 130068-27-8 (Interleukin-10). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3920%2fBM2019.0033
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Mitsou&issn=1876-2883&title=Beneficial+Microbes&atitle=Mining+possible+associations+of+faecal+A.+muciniphila+colonisation+patterns+with+host+adiposity+and+cardiometabolic+markers+in+an+adult+population.&volume=10&issue=7&spage=741&epage=749&date=2019&doi=10.3920%2FBM2019.0033&pmid=31965843&sid=OVID:medline
+
+<1944>
+Unique Identifier
+ 31933238
+Title
+ Applying Non-Invasive Fibrosis Measurements in NAFLD/NASH: Progress to Date. [Review]
+Source
+ Pharmaceutical Medicine. 33(6):451-463, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Albhaisi S; Sanyal AJ
+Authors Full Name
+ Albhaisi, Somaya; Sanyal, Arun J.
+Institution
+ Albhaisi, Somaya. Department of Internal Medicine, Virginia Commonwealth University, Box 980102, Richmond, VA, 23298, USA.
+ Sanyal, Arun J. Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Box 980341, Richmond, VA, 23298, USA. arun.sanyal@vcuhealth.org.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Biopsy/ae [Adverse Effects]
+ Biopsy/ec [Economics]
+ Circulating MicroRNA/bl [Blood]
+ Disease Progression
+ Elasticity Imaging Techniques/mt [Methods]
+ Gastrointestinal Microbiome
+ Humans
+ Liver/dg [Diagnostic Imaging]
+ Liver/me [Metabolism]
+ Liver/pa [Pathology]
+ Liver Cirrhosis/bl [Blood]
+ *Liver Cirrhosis/di [Diagnosis]
+ Liver Cirrhosis/ep [Epidemiology]
+ Liver Cirrhosis/pa [Pathology]
+ Metabolomics/mt [Methods]
+ Non-alcoholic Fatty Liver Disease/bl [Blood]
+ Non-alcoholic Fatty Liver Disease/di [Diagnosis]
+ Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ Observer Variation
+ Predictive Value of Tests
+ Prevalence
+ Proteomics/mt [Methods]
+ Risk Assessment
+ Severity of Illness Index
+ United States
+Abstract
+ Nonalcoholic fatty liver disease (NAFLD) has now become a worldwide health issue due to the obesity epidemic, affecting approximately 90% of the obese population and 15-40% of the general population. It is the most common form of chronic liver disease in the United States. NAFLD constitutes a spectrum of diseases ranging in severity from mild, such as fatty liver, progressing into nonalcoholic steatohepatitis (NASH), then fibrosis, and ending with cirrhosis. NASH and increasing fibrosis stage are associated with increased morbidity and mortality; the fibrosis stage is therefore a critical element of risk stratification needed to determine therapeutic approach and also the response to treatment. Liver biopsy is considered the 'gold standard' in the diagnosis of NAFLD. However, it is not practical for widespread clinical use because it is invasive, costly, and associated with complications including occasional death. These limitations have driven the development of noninvasive tests that can accurately predict the fibrosis stage in those with NAFLD. In this review, we provide a concise overview of different non-invasive measurements used for NAFLD/NASH.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Circulating MicroRNA).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs40290-019-00305-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Albhaisi&issn=1178-2595&title=Pharmaceutical+Medicine&atitle=Applying+Non-Invasive+Fibrosis+Measurements+in+NAFLD%2FNASH%3A+Progress+to+Date.&volume=33&issue=6&spage=451&epage=463&date=2019&doi=10.1007%2Fs40290-019-00305-z&pmid=31933238&sid=OVID:medline
+
+<1945>
+Unique Identifier
+ 31902144
+Title
+ Adult Stem Cells: Beyond Regenerative Tool, More as a Bio-Marker in Obesity and Diabetes. [Review]
+Source
+ Diabetes & Metabolism Journal. 43(6):744-751, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sen S
+Author NameID
+ Sen, Sabyasachi; ORCID: https://orcid.org/0000-0002-3675-9129
+Authors Full Name
+ Sen, Sabyasachi.
+Institution
+ Sen, Sabyasachi. Division of Endocrinology, Department of Medicine, The George Washington University, Washington, DC, USA. ssen1@gwu.edu.
+MeSH Subject Headings
+ Adipose Tissue/pa [Pathology]
+ Adult Stem Cells/de [Drug Effects]
+ *Adult Stem Cells/me [Metabolism]
+ Age Factors
+ Biomarkers/me [Metabolism]
+ Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Endothelial Progenitor Cells/de [Drug Effects]
+ *Endothelial Progenitor Cells/me [Metabolism]
+ *Exercise
+ Humans
+ Hypoglycemic Agents/ae [Adverse Effects]
+ Hypoglycemic Agents/pd [Pharmacology]
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ Mesenchymal Stem Cells/de [Drug Effects]
+ *Mesenchymal Stem Cells/me [Metabolism]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ *Regeneration
+Keyword Heading
+ Diabetes mellitus, type 2
+ Hematopoietic stem cells
+ Mesenchymal stem cells
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity, diabetes, and cardiovascular diseases are increasing rapidly worldwide and it is therefore important to know the effect of exercise and medications for diabetes and obesity on adult stem cells. Adult stem cells play a major role in remodeling and tissue regeneration. In this review we will focus mainly on two adult stem/progenitor cells such as endothelial progenitor cells and mesenchymal stromal cells in relation to aerobic exercise and diabetes medications, both of which can alter the course of regeneration and tissue remodelling. These two adult precursor and stem cells are easily obtained from peripheral blood or adipose tissue depots, as the case may be and are precursors to endothelium and mesenchymal tissue (fat, bone, muscle, and cartilage). They both are key players in maintenance of cardiovascular and metabolic homeostasis and can act also as useful biomarkers. Copyright © 2019 Korean Diabetes Association.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hypoglycemic Agents).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.4093%2fdmj.2019.0175
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sen&issn=2233-6079&title=Diabetes+%26+Metabolism+Journal&atitle=Adult+Stem+Cells%3A+Beyond+Regenerative+Tool%2C+More+as+a+Bio-Marker+in+Obesity+and+Diabetes.&volume=43&issue=6&spage=744&epage=751&date=2019&doi=10.4093%2Fdmj.2019.0175&pmid=31902144&sid=OVID:medline
+
+<1946>
+Unique Identifier
+ 31888499
+Title
+ Evaluation of alterations in serum immunoglobulin concentrations in components of metabolic syndrome, obesity, diabetes, and dyslipidemia.
+Source
+ BMC Cardiovascular Disorders. 19(1):319, 2019 12 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lin D; Bridgeman MB; Brunetti L
+Author NameID
+ Bridgeman, Mary Barna; ORCID: https://orcid.org/0000-0001-7947-9875
+ Brunetti, Luigi; ORCID: https://orcid.org/0000-0003-0565-6167
+Authors Full Name
+ Lin, Dee; Bridgeman, Mary Barna; Brunetti, Luigi.
+Institution
+ Lin, Dee. Health Outcomes Policy & Economics, Rutgers School of Public Health, Piscataway, NJ, USA.
+ Bridgeman, Mary Barna. Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA.
+ Bridgeman, Mary Barna. RWJBarnabas Health, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA.
+ Brunetti, Luigi. Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA. brunetti@pharmacy.rutgers.edu.
+ Brunetti, Luigi. RWJBarnabas Health, Robert Wood Johnson Somerset, Somerville, NJ, USA. brunetti@pharmacy.rutgers.edu.
+MeSH Subject Headings
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ *Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/im [Immunology]
+ *Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/im [Immunology]
+ Female
+ Humans
+ Immunoglobulin A/bl [Blood]
+ *Immunoglobulin G/bl [Blood]
+ Immunoglobulin M/bl [Blood]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/im [Immunology]
+ Middle Aged
+ New Jersey
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/im [Immunology]
+Keyword Heading
+ Cardiovascular disease
+ Diabetes
+ Dyslipidemia
+ Immunoglobulins
+ Metabolic syndrome
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Serum immunoglobulins (Igs) play a critical role in modulating the immune response by neutralizing pathogens, although little is known about the effect of Igs in development of atherosclerotic cardiovascular disease (ASCVD). Elevated serum Immunoglobulin A (IgA) concentrations have been identified in previous studies in populations with obesity and hypertriglyceridemia, whereas variable concentrations of Immunoglobulin M (IgM) have been observed in the setting of dyslipidemia.
+
+ METHODS: In this cross-sectional study, investigators examined the association of serum Ig concentrations with components of metabolic syndrome, including obesity, diabetes, and dyslipidemia. All consecutive adult patients aged 18 years or older discharged from two academic teaching hospitals with serum Immunoglobulin G (IgG) concentration measured during their admission were evaluated, with a total of 1809 individuals included and stratified into two groups: those with and those without dyslipidemia.
+
+ RESULTS: Mean IgG concentration in individuals with and without dyslipidemia was 997 +/- 485 mg/dL and 1144 +/- 677 mg/dL, respectively (P < 0.0001). After controlling for confounders in the generalized linear model (GLM), the least square mean IgG concentration in individuals with and without dyslipidemia was 1095 and 1239 mg/dL, respectively (P < 0.0001). The mean IgA and IgM concentrations were not significantly different in individuals with and without dyslipidemia both before and after adjusting covariates. After controlling for confounding variables, all three serum Ig concentrations were not significantly different in individuals with and without diabetes.
+
+ CONCLUSION: Dyslipidemia was associated with a lower mean serum IgG concentration. No association with any serum Ig was indentified in individuals with diabetes. Exploration of the association between alterations in serum Igs and metabolic syndrome and the role of alterations of Ig concentrations in disease progression represents an important step in identification of appropriate targeted treatment options for reducing cardiovascular risk.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Immunoglobulin A). 0 (Immunoglobulin G). 0 (Immunoglobulin M).
+Publication Type
+ Comparative Study. Journal Article. Multicenter Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12872-019-01296-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lin&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Evaluation+of+alterations+in+serum+immunoglobulin+concentrations+in+components+of+metabolic+syndrome%2C+obesity%2C+diabetes%2C+and+dyslipidemia.&volume=19&issue=1&spage=319&epage=&date=2019&doi=10.1186%2Fs12872-019-01296-0&pmid=31888499&sid=OVID:medline
+
+<1947>
+Unique Identifier
+ 31888234
+Title
+ Amaranth Oil Increases Total and LDL Cholesterol Levels without Influencing Early Markers of Atherosclerosis in an Overweight and Obese Population: A Randomized Double-Blind Cross-Over Study in Comparison with Rapeseed Oil Supplementation.
+Source
+ Nutrients. 11(12), 2019 Dec 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dus-Zuchowska M; Walkowiak J; Morawska A; Krzyzanowska-Jankowska P; Miskiewicz-Chotnicka A; Przyslawski J; Lisowska A
+Author NameID
+ Walkowiak, Jaroslaw; ORCID: https://orcid.org/0000-0001-5813-5707
+Authors Full Name
+ Dus-Zuchowska, Monika; Walkowiak, Jaroslaw; Morawska, Anna; Krzyzanowska-Jankowska, Patrycja; Miskiewicz-Chotnicka, Anna; Przyslawski, Juliusz; Lisowska, Aleksandra.
+Institution
+ Dus-Zuchowska, Monika. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 60-572 Poznan, Poland.
+ Walkowiak, Jaroslaw. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 60-572 Poznan, Poland.
+ Morawska, Anna. Department of Bromatology, Poznan University of Medical Sciences, 60-354 Poznan, Poland.
+ Krzyzanowska-Jankowska, Patrycja. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 60-572 Poznan, Poland.
+ Miskiewicz-Chotnicka, Anna. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 60-572 Poznan, Poland.
+ Przyslawski, Juliusz. Department of Bromatology, Poznan University of Medical Sciences, 60-354 Poznan, Poland.
+ Lisowska, Aleksandra. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 60-572 Poznan, Poland.
+MeSH Subject Headings
+ Adult
+ *Amaranthus
+ Atherosclerosis/et [Etiology]
+ *Atherosclerosis/pc [Prevention & Control]
+ Biomarkers/bl [Blood]
+ Cholesterol/bl [Blood]
+ Cholesterol, LDL/bl [Blood]
+ Cross-Over Studies
+ *Dietary Supplements
+ Double-Blind Method
+ Female
+ Humans
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ *Overweight/bl [Blood]
+ Overweight/co [Complications]
+ Overweight/th [Therapy]
+ *Plant Oils/ad [Administration & Dosage]
+ *Rapeseed Oil/ad [Administration & Dosage]
+Keyword Heading
+ amaranth oil
+ atherosclerosis
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Atherosclerosis (AT) is a chronic inflammatory process in which oxidative stress is the key event. Amaranth oil (AmO) has potential hypolipidemic and antiatherogenic effects. The aim of the study was to compare the effects of AmO and rapeseed oil (RaO) supplementation on expression of early markers of AT and lipid profile in obese or overweight subjects.
+
+ METHODS: A randomized, double-blinded cross-over study was conducted, in which participants took 20 mL of AmO in the first arm and 20 mL RaO in the second arm, switching after the washout period. Serum concentrations of adhesion molecules (sP-selectin, sVCAM-1), high-sensitivity C-reactive protein (hsCRP), asymmetric dimethylarginine (ADMA), and lipid profile were assessed before and after nutritional interventions. In addition, anthropometric parameters were measured.
+
+ RESULTS: The total (TC) and low-density lipoprotein (LDL) cholesterol concentrations increased significantly in the AmO group in comparison with RaO (DELTATC 5.52 +/- 35 vs. -8.43 +/- 17.65 mg/dL; p = 0.002 and 4.43 +/- 34.96 vs. -7.55 +/- 16.41 mg/dL; p = 0.002, respectively). There were no significant differences in other parameters analyzed between the groups.
+
+ CONCLUSION: The use of AmO instead of RaO may increase cardiovascular risk in obese and overweight subjects.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL). 0 (Lipids). 0 (Plant Oils). 0 (Rapeseed Oil). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11123069
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dus-Zuchowska&issn=2072-6643&title=Nutrients&atitle=Amaranth+Oil+Increases+Total+and+LDL+Cholesterol+Levels+without+Influencing+Early+Markers+of+Atherosclerosis+in+an+Overweight+and+Obese+Population%3A+A+Randomized+Double-Blind+Cross-Over+Study+in+Comparison+with+Rapeseed+Oil+Supplementation.&volume=11&issue=12&spage=&epage=&date=2019&doi=10.3390%2Fnu11123069&pmid=31888234&sid=OVID:medline
+
+<1948>
+Unique Identifier
+ 31882939
+Title
+ Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARgamma signaling.
+Source
+ Scientific Reports. 9(1):20152, 2019 12 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Park SS; Lee YJ; Kang H; Yang G; Hong EJ; Lim JY; Oh S; Kim E
+Author NameID
+ Kim, Eungseok; ORCID: http://orcid.org/0000-0003-4935-7839
+Authors Full Name
+ Park, Sung-Soo; Lee, Yeon-Joo; Kang, Hyuno; Yang, Garam; Hong, Eun Jeong; Lim, Jin Yeong; Oh, Sejong; Kim, Eungseok.
+Institution
+ Park, Sung-Soo. Department of Biological Sciences, College of Natural Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
+ Park, Sung-Soo. Research and Development Division, World Institute of Kimchi, 86 kimchi-ro, Nam-gu, Gwangju, 61755, Republic of Korea.
+ Lee, Yeon-Joo. Department of Biological Sciences, College of Natural Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
+ Kang, Hyuno. Division of Analytical Science, Korea Basic Science Institute, 169-148 Gwahak-ro, Yuseong-gu, Daejeon, 34133, Republic of Korea.
+ Yang, Garam. Department of Biological Sciences, College of Natural Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
+ Hong, Eun Jeong. Department of Biological Sciences, College of Natural Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
+ Lim, Jin Yeong. Division of Analytical Science, Korea Basic Science Institute, 169-148 Gwahak-ro, Yuseong-gu, Daejeon, 34133, Republic of Korea.
+ Oh, Sejong. Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea. soh@jnu.ac.kr.
+ Kim, Eungseok. Department of Biological Sciences, College of Natural Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea. ekim@jnu.ac.kr.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ Adipocytes/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue, Brown/me [Metabolism]
+ Animals
+ Biomarkers
+ Cell Line
+ Diet, High-Fat/ae [Adverse Effects]
+ *Diet, High-Fat
+ Disease Susceptibility
+ Gene Expression
+ Humans
+ *Lactobacillus acidophilus/ph [Physiology]
+ Lipid Metabolism
+ Mice
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ *PPAR gamma/me [Metabolism]
+ Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/me [Metabolism]
+ Phenotype
+ Probiotics/ad [Administration & Dosage]
+ *Probiotics
+ Protein Binding
+ *Signal Transduction
+Abstract
+ Browning of white adipose tissue (WAT) is currently considered a potential therapeutic strategy to treat diet-induced obesity. While some probiotics have protective effects against diet-induced obesity, the role of probiotics in adipose browning has not been explored. Here, we show that administration of the probiotic bacterium Lactobacillus amylovorus KU4 (LKU4) to mice fed a high-fat diet (HFD) enhanced mitochondrial levels and function, as well as the thermogenic gene program (increased Ucp1, PPARgamma, and PGC-1alpha expression and decreased RIP140 expression), in subcutaneous inguinal WAT and also increased body temperature. Furthermore, LKU4 administration increased the interaction between PPARgamma and PGC-1alpha through release of RIP140 to stimulate Ucp1 expression, thereby promoting browning of white adipocytes. In addition, lactate, the levels of which are elevated in plasma of HFD-fed mice following LKU4 administration, elicited the same effect on the interaction between PPARgamma and PGC-1alpha in 3T3-L1 adipocytes, leading to a brown-like adipocyte phenotype that included enhanced Ucp1 expression, mitochondrial levels and function, and oxygen consumption rate. Together, these data reveal that LKU4 facilitates browning of white adipocytes through the PPARgamma-PGC-1alpha transcriptional complex, at least in part by increasing lactate levels, leading to inhibition of diet-induced obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (PPAR gamma). 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha). 0 (Ppargc1a protein, mouse).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-56817-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Park&issn=2045-2322&title=Scientific+Reports&atitle=Lactobacillus+amylovorus+KU4+ameliorates+diet-induced+obesity+in+mice+by+promoting+adipose+browning+through+PPARgamma+signaling.&volume=9&issue=1&spage=20152&epage=&date=2019&doi=10.1038%2Fs41598-019-56817-w&pmid=31882939&sid=OVID:medline
+
+<1949>
+Unique Identifier
+ 31875134
+Title
+ Abdominal visceral and subcutaneous adipose tissues in association with cardiometabolic risk in children and adolescents: the China Child and Adolescent Cardiovascular Health (CCACH) study.
+Source
+ BMJ Open Diabetes Research & Care. 7(1):e000824, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yan Y; Liu J; Zhao X; Cheng H; Huang G; Mi J
+Author NameID
+ Mi, Jie; ORCID: https://orcid.org/0000-0003-0630-8447
+Corporate Author
+ China Child and Adolescent Cardiovascular Health study (CCACH) research group
+Authors Full Name
+ Yan, Yinkun; Liu, Junting; Zhao, Xiaoyuan; Cheng, Hong; Huang, Guimin; Mi, Jie.
+Institution
+ Yan, Yinkun. Department of Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
+ Liu, Junting. Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
+ Zhao, Xiaoyuan. Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
+ Cheng, Hong. Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
+ Huang, Guimin. Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
+ Mi, Jie. Department of Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
+ Mi, Jie. Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
+MeSH Subject Headings
+ *Abdominal Fat/pp [Physiopathology]
+ Adolescent
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pa [Pathology]
+ Child
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ *Intra-Abdominal Fat/pp [Physiopathology]
+ Male
+ *Metabolic Diseases/ep [Epidemiology]
+ Metabolic Diseases/et [Etiology]
+ Metabolic Diseases/pa [Pathology]
+ *Obesity/co [Complications]
+ Prognosis
+ Risk Factors
+ Sexual Maturation
+ *Subcutaneous Fat/pp [Physiopathology]
+Keyword Heading
+ abdominal fat
+ children
+ metabolic risk factors
+ subcutaneous adipose tissue
+ visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: To investigate the association of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with cardiometabolic risk factors in children and adolescents.
+
+ Research design and methods: This cross-sectional study consisted of 8460 children and adolescents aged 6-18 years from Chinese urban areas who underwent dual-energy X-ray absorptiometry scan and had metabolic risk factors measured.
+
+ Results: In multivariate analysis adjusted for region, family income, age, puberty development, physical activity, and smoking, VAT and SAT were significantly associated with all metabolic risk factors for both sexes (all p<0.01). After additional adjustment for fat mass index, most of these associations remain significantly positive. In boys, SAT had greater ORs for all risk factors compared with VAT; in girls, however, SAT had greater odds for high triglycerides, smaller odds for high low-density lipid cholesterol, and similar odds for other risk factors compared with VAT. In addition, boys had greater magnitude of associations of SAT with high total cholesterol, high low-density lipid cholesterol, and low high-density lipid cholesterol compared with girls; no sex differences for VAT were observed.
+
+ Conclusions: Both abdominal VAT and SAT have adverse impacts on most of the cardiometabolic risk factors in youth. However, their relative contributions differ between sexes. Copyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1136%2fbmjdrc-2019-000824
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yan&issn=2052-4897&title=BMJ+Open+Diabetes+Research+%26+Care&atitle=Abdominal+visceral+and+subcutaneous+adipose+tissues+in+association+with+cardiometabolic+risk+in+children+and+adolescents%3A+the+China+Child+and+Adolescent+Cardiovascular+Health+%28CCACH%29+study.&volume=7&issue=1&spage=e000824&epage=&date=2019&doi=10.1136%2Fbmjdrc-2019-000824&pmid=31875134&sid=OVID:medline
+
+<1950>
+Unique Identifier
+ 31874865
+Title
+ Stress management in obesity during a thermal spa residential programme (ObesiStress): protocol for a randomised controlled trial study.
+Source
+ BMJ Open. 9(12):e027058, 2019 12 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dutheil F; Chaplais E; Vilmant A; Courteix D; Duche P; Abergel A; Pfabigan DM; Han S; Mobdillon L; Vallet GT; Mermillod M; Boudet G; Obert P; Izem O; Miolanne-Debouit M; Farigon N; Pereira B; Boirie Y
+Author NameID
+ Chaplais, Elodie; ORCID: https://orcid.org/0000-0003-4936-369X
+Authors Full Name
+ Dutheil, Frederic; Chaplais, Elodie; Vilmant, Audrey; Courteix, Daniel; Duche, Pascale; Abergel, Armand; Pfabigan, Daniela M; Han, Shihui; Mobdillon, Laurie; Vallet, Guillaume T; Mermillod, Martial; Boudet, Gil; Obert, Philippe; Izem, Omar; Miolanne-Debouit, Magalie; Farigon, Nicolas; Pereira, Bruno; Boirie, Yves.
+Institution
+ Dutheil, Frederic. Universite Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Preventive and Occupational Medicine, WittyFit, Clermont-Ferrand, France.
+ Chaplais, Elodie. Universite de Lorraine, Laboratory "Development, Adaption and Disability" (DevAH - EA 3450), Nancy, France elodie.chaplais@acu.edu.au.
+ Chaplais, Elodie. University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Biostatistics Unit, Clinical research and Innovation Department (DRCI), Biostatistics, Clermont-Ferrand, France.
+ Vilmant, Audrey. Universite Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Preventive and Occupational Medicine, WittyFit, Clermont-Ferrand, France.
+ Courteix, Daniel. Universite Clermont Auvergne, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P - EA 3533), Clermont-Ferrand, France.
+ Duche, Pascale. Universite de Toulon, Laboratory of Impact of Physical Activity on Health (IAPS), Toulon, France.
+ Abergel, Armand. Universite Clermont Auvergne, CNRS, UMR 6284, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Hepatology Gastroenterology, Clermont-Ferrand, France.
+ Pfabigan, Daniela M. School of Psychological and Cognitive Sciences, PKU-IDG/McGovern Institute for Brain Research, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.
+ Han, Shihui. School of Psychological and Cognitive Sciences, PKU-IDG/McGovern Institute for Brain Research, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.
+ Mobdillon, Laurie. Universite Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, Clermont-Ferrand, France.
+ Vallet, Guillaume T. Universite Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, Clermont-Ferrand, France.
+ Mermillod, Martial. Universite Grenoble Alpes, Universite Savoie Mont Blanc, LPNC, CNRS, Grenoble, France.
+ Mermillod, Martial. Institut Universitaire de France, Paris, France.
+ Boudet, Gil. Universite Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Preventive and Occupational Medicine, WittyFit, Clermont-Ferrand, France.
+ Obert, Philippe. Universite d'Avignon, Laboratory of Cardiovascular Pharm-ecology (LaPEC EA4278), Avignon, France.
+ Izem, Omar. Universite d'Avignon, Laboratory of Cardiovascular Pharm-ecology (LaPEC EA4278), Avignon, France.
+ Miolanne-Debouit, Magalie. University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Unit of Human Nutrition, Clermont-Ferrand, France.
+ Farigon, Nicolas. University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Unit of Human Nutrition, Clermont-Ferrand, France.
+ Pereira, Bruno. University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Biostatistics Unit, Clinical research and Innovation Department (DRCI), Biostatistics, Clermont-Ferrand, France.
+ Boirie, Yves. Universite Clermont Auvergne, INRA, CRNH, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Unit of Human Nutrition, Clermont-Ferrand, France.
+MeSH Subject Headings
+ Biomarkers/me [Metabolism]
+ Body Composition
+ Body Mass Index
+ France
+ Heart Rate
+ Humans
+ *Hyperthermia, Induced
+ *Obesity/th [Therapy]
+ Overweight/th [Therapy]
+ Quality of Life
+ Randomized Controlled Trials as Topic
+ *Stress, Psychological/th [Therapy]
+Keyword Heading
+ heart rate variability
+ obesity
+ prevention
+ spa bath
+ stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: Stress and obesity are two public health issues. The relationship between obesity and stress is biological through the actions of stress on the major hormones that regulate appetite (leptin and ghrelin). Many spa resorts in France specialise in the treatment of obesity, but no thermal spa currently proposes a specific programme to manage stress in obesity. The ObesiStress protocol has been designed to offer a new residential stress management programme. This thermal spa treatment of obesity implements stress management strategies as suggested by international recommendations.
+
+ METHODS AND ANALYSIS: 140 overweight or obese participants with a Body Mass Index of >25 kg/m2 and aged over 18 years will be recruited. Participants will be randomised into two groups: a control group of usual practice (restrictive diet, physical activity and thermal spa treatment) and an intervention group with stress management in addition to the usual practice. In the present protocol, parameters will be measured on five occasions (at inclusion, at the beginning of the spa (day 0), at the end of the spa (day 21), and at 6 and 12 months). The study will assess the participants' heart rate variability, cardiac remodelling and function, electrodermal activity, blood markers, anthropometric profile, body composition, psychology and quality of life via the use of questionnaires and bone parameters.
+
+ ETHICS AND DISSEMINATION: The ObesiStress protocol complies with the ethics guidelines for Clinical Research and has been approved by the ethics committee (CPP Sud-Est VI, Clermont-Ferrand - ANSM: 2016-A01774-47). This study aimed to highlight the efficacy of a 21-day thermal spa residential programme of stress management in obesity through objective measurements of well-being and cardiovascular morbidity. Results will be disseminated during several research conferences and articles published in peer-reviewed journals.
+
+ TRIAL REGISTRATION NUMBER: NCT03578757. Copyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Clinical Trial Protocol. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1136%2fbmjopen-2018-027058
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dutheil&issn=2044-6055&title=BMJ+Open&atitle=Stress+management+in+obesity+during+a+thermal+spa+residential+programme+%28ObesiStress%29%3A+protocol+for+a+randomised+controlled+trial+study.&volume=9&issue=12&spage=e027058&epage=&date=2019&doi=10.1136%2Fbmjopen-2018-027058&pmid=31874865&sid=OVID:medline
+
+<1951>
+Unique Identifier
+ 31871945
+Title
+ Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults.
+Source
+ Journal of Diabetes Research. 2019:3175418, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li L; Song Q; Yang X
+Author NameID
+ Li, Li; ORCID: https://orcid.org/0000-0001-6301-3544
+ Song, Qifa; ORCID: https://orcid.org/0000-0001-9753-2924
+Authors Full Name
+ Li, Li; Song, Qifa; Yang, Xi.
+Institution
+ Li, Li. Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang, China.
+ Song, Qifa. Ningbo Municipal Centre for Disease Control and Prevention, Ningbo, Zhejiang, China.
+ Yang, Xi. Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang, China.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Blood Pressure
+ Body Mass Index
+ China/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ *Dyslipidemias/ep [Epidemiology]
+ Female
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Hypertension/di [Diagnosis]
+ *Hypertension/ep [Epidemiology]
+ Hypertension/pp [Physiopathology]
+ Hyperuricemia/bl [Blood]
+ Hyperuricemia/di [Diagnosis]
+ *Hyperuricemia/ep [Epidemiology]
+ Lipids/bl [Blood]
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ *Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Risk Assessment
+ Risk Factors
+ Up-Regulation
+ *Uric Acid/bl [Blood]
+ Young Adult
+Abstract
+ The overweight and obese population experiences a higher occurrence of both hyperuricemia and metabolic syndrome. The present study was to explore the relationship between serum uric acid and metabolic syndrome-related risk factors among 409 obese Chinese adults (254 women and 155 men) with >24 kg/m2 BMI. Based on sex-specific reference ranges, 233 (57%) patients showed elevated serum uric acid. A total of 15 attributes were selected to assess the associations between elevated serum uric acid and components of metabolic syndrome, including serum uric acid, total cholesterol, HDL-C, LDL-C, triglyceride, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, alanine aminotransferase, creatinine, urine microalbumin, muscle mass amount, BMI, and age. Among the participants stratified into three groups of grade I, grade II, and grade III obesity, as well as among the participants stratified into male and female groups, univariate correlation analysis identified a negative association (P < 0.01) for age, positive associations (P < 0.01) for BMI, muscle mass, alanine aminotransferase, and creatinine. The stepwise multivariate logistic regression proved similar associations for age, BMI, creatinine, and alanine aminotransferase. No significant associations were testified between serum uric acid levels and cholesterol, HDL-C, LDL-C, triglyceride, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, and urine microalbumin. Factor analysis illustrated that 15 attributes could be grouped into two common factors and five individual factors. A common underlying factor was identified among uric acid, muscle mass, creatinine, alanine aminotransferase, and BMI. The results indicate that serum uric acid has no apparent association with metabolic syndromes that are commonly characterized by hypertension, dyslipidemia, and T2DM. Copyright © 2019 Li Li et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Lipids). 0 (hemoglobin A1c protein, human). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f3175418
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=Lack+of+Associations+between+Elevated+Serum+Uric+Acid+and+Components+of+Metabolic+Syndrome+Such+as+Hypertension%2C+Dyslipidemia%2C+and+T2DM+in+Overweight+and+Obese+Chinese+Adults.&volume=2019&issue=&spage=3175418&epage=&date=2019&doi=10.1155%2F2019%2F3175418&pmid=31871945&sid=OVID:medline
+
+<1952>
+Unique Identifier
+ 31860245
+Title
+ NASH and liver cancer: the new cancer headline.
+Source
+ American Journal of Managed Care. 25(11 Spec No.):SP334-SP335, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cryer D
+Authors Full Name
+ Cryer, Donna.
+MeSH Subject Headings
+ Biomarkers
+ Biomedical Research/og [Organization & Administration]
+ Cost of Illness
+ Health Expenditures
+ Health Policy
+ Humans
+ *Liver Neoplasms/ep [Epidemiology]
+ Metabolic Syndrome/ep [Epidemiology]
+ Non-alcoholic Fatty Liver Disease/ec [Economics]
+ *Non-alcoholic Fatty Liver Disease/ep [Epidemiology]
+ *Obesity/ep [Epidemiology]
+ United States/ep [Epidemiology]
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&AN=31860245
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cryer&issn=1088-0224&title=American+Journal+of+Managed+Care&atitle=NASH+and+liver+cancer%3A+the+new+cancer+headline.&volume=25&issue=11&spage=SP334&epage=SP335&date=2019&doi=&pmid=31860245&sid=OVID:medline
+
+<1953>
+Unique Identifier
+ 31851936
+Title
+ Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning.
+Source
+ Cell Reports. 29(12):4099-4113.e5, 2019 12 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li Y; Schwalie PC; Bast-Habersbrunner A; Mocek S; Russeil J; Fromme T; Deplancke B; Klingenspor M
+Authors Full Name
+ Li, Yongguo; Schwalie, Petra C; Bast-Habersbrunner, Andrea; Mocek, Sabine; Russeil, Julie; Fromme, Tobias; Deplancke, Bart; Klingenspor, Martin.
+Institution
+ Li, Yongguo. Chair for Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; EKFZ-Else Kroner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany.
+ Schwalie, Petra C. Institute of Bio-engineering, School of Life Sciences, EPFL and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
+ Bast-Habersbrunner, Andrea. Chair for Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; EKFZ-Else Kroner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany.
+ Mocek, Sabine. Chair for Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; EKFZ-Else Kroner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany.
+ Russeil, Julie. Institute of Bio-engineering, School of Life Sciences, EPFL and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
+ Fromme, Tobias. Chair for Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; EKFZ-Else Kroner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany.
+ Deplancke, Bart. Institute of Bio-engineering, School of Life Sciences, EPFL and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland. Electronic address: bart.deplancke@epfl.ch.
+ Klingenspor, Martin. Chair for Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; EKFZ-Else Kroner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany. Electronic address: mk@tum.de.
+MeSH Subject Headings
+ Adipocytes, Beige/cy [Cytology]
+ *Adipocytes, Beige/me [Metabolism]
+ *Adipogenesis
+ Adipose Tissue, Brown/cy [Cytology]
+ *Adipose Tissue, Brown/me [Metabolism]
+ Adipose Tissue, White/cy [Cytology]
+ *Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Energy Metabolism
+ Female
+ Gene Expression Profiling
+ Gene Expression Regulation
+ *Gene Regulatory Networks
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Knockout
+ *Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ Signal Transduction
+ Systems Biology
+ Thermogenesis
+ *Uncoupling Protein 1/ph [Physiology]
+Keyword Heading
+ UCP1
+ adipose tissue
+ brite/beige adipogenesis
+ browning, thermogenesis
+ inbred mouse strains
+ molecular network
+ obesity
+ transcription factor
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Recruitment of brite/beige cells, known as browning of white adipose tissue (WAT), is an efficient way to turn an energy-storing organ into an energy-dissipating one and may therefore be of therapeutic value in combating obesity. However, a comprehensive understanding of the regulatory mechanisms mediating WAT browning is still lacking. Here, we exploit the large natural variation in WAT browning propensity between inbred mouse strains to gain an inclusive view of the core regulatory network coordinating this cellular process. Combining comparative transcriptomics, perturbation-based validations, and gene network analyses, we present a comprehensive gene regulatory network of inguinal WAT browning, revealing up to four distinct regulatory modules with key roles for uncovered transcriptional factors, while also providing deep insights into the genetic architecture of brite adipogenesis. The presented findings therefore greatly increase our understanding of the molecular drivers mediating the intriguing cellular heterogeneity and plasticity of adipose tissue. Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Ucp1 protein, mouse). 0 (Uncoupling Protein 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.celrep.2019.11.053
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=2211-1247&title=Cell+Reports&atitle=Systems-Genetics-Based+Inference+of+a+Core+Regulatory+Network+Underlying+White+Fat+Browning.&volume=29&issue=12&spage=4099&epage=4113.e5&date=2019&doi=10.1016%2Fj.celrep.2019.11.053&pmid=31851936&sid=OVID:medline
+
+<1954>
+Unique Identifier
+ 31846701
+Title
+ Adipose tissue browning in cardiometabolic health and disease.
+Source
+ Hjc Hellenic Journal of Cardiology. 60(5):294-295, 2019 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Antonopoulos AS; Tousoulis D
+Authors Full Name
+ Antonopoulos, Alexios S; Tousoulis, Dimitris.
+Institution
+ Antonopoulos, Alexios S. 1st Cardiology Department, Hippokration Hospital, University of Athens, Greece. Electronic address: alexios.antonopoulos@cardiov.ox.ac.uk.
+ Tousoulis, Dimitris. 1st Cardiology Department, Hippokration Hospital, University of Athens, Greece.
+Comments
+ Comment on (CON)
+MeSH Subject Headings
+ Adipose Tissue
+ Biomarkers
+ *Cardiovascular Diseases
+ Humans
+ *Obesity
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Editorial. Comment.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.hjc.2019.12.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Antonopoulos&issn=1109-9666&title=Hjc+Hellenic+Journal+of+Cardiology&atitle=Adipose+tissue+browning+in+cardiometabolic+health+and+disease.&volume=60&issue=5&spage=294&epage=295&date=2019&doi=10.1016%2Fj.hjc.2019.12.005&pmid=31846701&sid=OVID:medline
+
+<1955>
+Unique Identifier
+ 31841546
+Title
+ Gestational diabetes mellitus diagnosed at 24 to 28 weeks of gestation in older and obese Women: Is it too late?.
+Source
+ PLoS ONE [Electronic Resource]. 14(12):e0225955, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim W; Park SK; Kim YL
+Author NameID
+ Kim, Wonjin; ORCID: https://orcid.org/0000-0002-0689-4100
+Authors Full Name
+ Kim, Wonjin; Park, Soo Kyung; Kim, Yoo Lee.
+Institution
+ Kim, Wonjin. Department of Internal Medicine, Division of Endocrinology and Metabolism, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
+ Kim, Wonjin. Yonsei University College of Medicine, Seoul, Korea.
+ Park, Soo Kyung. Departmentof Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, Maryland, United States of America.
+ Kim, Yoo Lee. Department of Internal Medicine, Division of Endocrinology and Metabolism, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Biomarkers
+ *Diabetes, Gestational/di [Diagnosis]
+ *Diabetes, Gestational/ep [Epidemiology]
+ Diabetes, Gestational/et [Etiology]
+ Female
+ Fetal Development
+ Fetal Macrosomia/ep [Epidemiology]
+ Fetal Macrosomia/et [Etiology]
+ *Gestational Age
+ Glucose Tolerance Test
+ Humans
+ Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ Pregnancy
+ Prevalence
+ Retrospective Studies
+ Time Factors
+Abstract
+ AIM/BACKGROUND: The prevalence of elderly pregnancy and maternal obesity is increasing worldwide. In old and obese women, metabolic derangement affecting fetal growth might be present earlier than the diagnosis of gestational diabetes mellitus (GDM) or even before pregnancy. We thus investigated whether GDM diagnosed at 24-28 weeks of gestation had already affected fetal abdominal growth and, if so, whether elderly pregnancy and/or maternal obesity aggravate fetal abdominal obesity.
+
+ METHODS: We retrospectively reviewed the medical records of 7820 singleton pregnant women who had been universally screened using a 50-g glucose challenge test (GCT) at 24-28 weeks of gestation, and underwent a 3-h 100-g oral glucose tolerance test (OGTT) if GCT were >=140mg/dl. GDM and normal glucose tolerance (NGT) were diagnosed using the Carpenter-Coustan criteria. Fetal abdominal obesity was investigated by assessing the fetal abdominal overgrowth ratios (FAORs) of the ultrasonographically estimated gestational age (GA) of abdominal circumference per actual GA by the last menstruation period, biparietal diameter or femur length, respectively. Fetal abdominal overgrowth was defined as FAOR >= 90th percentile. The subjects were divided into four study groups: group 1 (age < 35 years and pre-pregnancy body mass index [BMI] < 25 kg/m2), group 2 (age < 35 years and >= 25), group 3 (age >= 35 years and BMI < 25), and group 4 (age >= 35 years and >= 25).
+
+ RESULTS: The overall prevalence of GDM was 5.1%, with old and obese group 4 exhibiting the highest prevalence (22.4%). FAORs were significantly higher in the fetus of those with GDM than in the NGT subjects. But, in the subgroup analysis, only old and nonobese group 3 and old and obese group 4 with GDM exhibited significantly higher FAORs than the NGT subjects. Also, risk of fetal abdominal overgrowth was increased in group 3 and 4 subjects with GDM but not in young and nonobese group 1 GDM. The risk of fetal abdominal overgrowth significantly increased with maternal age >35 years, pre-pregnancy BMI >20kg/m2, and HbA1c >37.7 mmol/mol (5.6%). In multivariate analyses, maternal age and HbA1c were significantly associated with FAORs.
+
+ CONCLUSION: GDM diagnosed at 24-28 weeks of gestation already affected fetal abdominal obesity in older and/or obese women, but not in younger and nonobese women. Our data suggest that selective screening and appropriate intervention of GDM earlier than 24-28 weeks of gestation might be necessary for high-risk old and/or obese women.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0225955
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Gestational+diabetes+mellitus+diagnosed+at+24+to+28+weeks+of+gestation+in+older+and+obese+Women%3A+Is+it+too+late%3F.&volume=14&issue=12&spage=e0225955&epage=&date=2019&doi=10.1371%2Fjournal.pone.0225955&pmid=31841546&sid=OVID:medline
+
+<1956>
+Unique Identifier
+ 31835508
+Title
+ Twelve Weeks of Combined Resistance and Aerobic Exercise Improves Cardiometabolic Biomarkers and Enhances Red Blood Cell Hemorheological Function in Obese Older Men: A Randomized Controlled Trial.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 16(24), 2019 12 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim SW; Jung WS; Park W; Park HY
+Author NameID
+ Park, Wonil; ORCID: https://orcid.org/0000-0002-1623-6398
+ Park, Hun-Young; ORCID: https://orcid.org/0000-0002-9901-7624
+Authors Full Name
+ Kim, Sung-Woo; Jung, Won-Sang; Park, Wonil; Park, Hun-Young.
+Institution
+ Kim, Sung-Woo. Physical Activity and Performance Institute (PAPI), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
+ Jung, Won-Sang. Physical Activity and Performance Institute (PAPI), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
+ Park, Wonil. Department of Physical Education, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea.
+ Park, Hun-Young. Physical Activity and Performance Institute (PAPI), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
+ Park, Hun-Young. Department of Sports Medicine and Science, Graduate School, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ Blood Glucose/an [Analysis]
+ Body Composition
+ Cardiovascular Diseases/pc [Prevention & Control]
+ Erythrocytes/ph [Physiology]
+ *Exercise
+ *Exercise Therapy
+ Hemorheology
+ Humans
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Leptin/bl [Blood]
+ Male
+ Metabolic Syndrome/pc [Prevention & Control]
+ Obesity/bl [Blood]
+ *Obesity/th [Therapy]
+Keyword Heading
+ RBC hemorheological parameters
+ aerobic performance
+ cardiometabolic biomarkers
+ combined exercise
+ obese older men
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The present study examined the effect of a 12-week combined resistance and aerobic exercise training program on cardiometabolic biomarkers and red blood cell (RBC) hemorheological function in 20 obese older men (mean age: 68.8 +/- 0.9 years). Subjects were randomly divided into two groups (exercise intervention [EXP; n = 10] and control [CON; n = 10]). The EXP subjects performed resistance and aerobic exercise training program three times per week for 12 weeks, and the CON subjects maintained their regular lifestyle during the intervention period. Body composition was estimated using bioelectrical impedance analysis equipment. Cardiometabolic biomarkers (glucose, insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), HOMA beta-cell function, and leptin) and RBC hemorheological parameters (RBC deformability and aggregation) were analyzed. Percent body fat decreased significantly in the EXP group during the intervention period but increased significantly in the CON group. Insulin increased significantly in the CON group over the 12-week period and both insulin and HOMA-IR were significantly higher in the CON group than in the EXP group at post-test. RBC deformability (RBC EI_3Pa) and aggregation (RBC AI_3Pa) improved significantly only in the EXP group. The present study suggests that combined exercise training can be useful for improving cardiometabolic biomarkers and RBC hemorheological parameters in obese older men and may help prevent metabolic syndrome and cardiovascular diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Leptin).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijerph16245020
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Twelve+Weeks+of+Combined+Resistance+and+Aerobic+Exercise+Improves+Cardiometabolic+Biomarkers+and+Enhances+Red+Blood+Cell+Hemorheological+Function+in+Obese+Older+Men%3A+A+Randomized+Controlled+Trial.&volume=16&issue=24&spage=&epage=&date=2019&doi=10.3390%2Fijerph16245020&pmid=31835508&sid=OVID:medline
+
+<1957>
+Unique Identifier
+ 31832204
+Title
+ Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case.
+Source
+ Pharmacology Research & Perspectives. 7(6):e00543, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Johns DG; Wang SP; Rosa R; Hubert J; Xu S; Chen Y; Bateman T; Blaustein RO
+Author NameID
+ Johns, Douglas G; ORCID: https://orcid.org/0000-0002-8726-8514
+Authors Full Name
+ Johns, Douglas G; Wang, Sheng-Ping; Rosa, Raymond; Hubert, James; Xu, Suoyu; Chen, Ying; Bateman, Thomas; Blaustein, Robert O.
+Institution
+ Johns, Douglas G. Department of Translational Pharmacology Merck & Co., Inc. Kenilworth NJ USA.
+ Wang, Sheng-Ping. Department of Cardiometabolic Diseases/Atherosclerosis Merck & Co., Inc. Kenilworth NJ USA.
+ Rosa, Raymond. Department of Cardiometabolic Diseases/Atherosclerosis Merck & Co., Inc. Kenilworth NJ USA.
+ Hubert, James. Department of Cardiometabolic Diseases/Atherosclerosis Merck & Co., Inc. Kenilworth NJ USA.
+ Xu, Suoyu. Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism Merck & Co., Inc. Kenilworth NJ USA.
+ Chen, Ying. Department of Cardiometabolic Diseases/Atherosclerosis Merck & Co., Inc. Kenilworth NJ USA.
+ Bateman, Thomas. Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism Merck & Co., Inc. Kenilworth NJ USA.
+ Blaustein, Robert O. Department of Clinical Research Merck & Co., Inc. Kenilworth NJ USA.
+MeSH Subject Headings
+ *Adipose Tissue, White/de [Drug Effects]
+ Adipose Tissue, White/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ Caloric Restriction
+ Cholesterol Ester Transfer Proteins/ai [Antagonists & Inhibitors]
+ Cholesterol, HDL/bl [Blood]
+ Cholesterol, HDL/me [Metabolism]
+ Cholesterol, LDL/bl [Blood]
+ Cholesterol, LDL/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Humans
+ Hypolipidemic Agents/ad [Administration & Dosage]
+ *Hypolipidemic Agents/pk [Pharmacokinetics]
+ Lipid Metabolism/de [Drug Effects]
+ Male
+ Mice
+ Obesity/bl [Blood]
+ Obesity/dt [Drug Therapy]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Oxazolidinones/ad [Administration & Dosage]
+ *Oxazolidinones/pk [Pharmacokinetics]
+ Tissue Distribution
+ Weight Loss
+Keyword Heading
+ adipose
+ anacetrapib
+ cholesteryl ester transfer protein
+ pharmacokinetics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid-modifying agent that reduces LDL-cholesterol and increases HDL-cholesterol in hypercholesterolemic patients. Anacetrapib demonstrates a long terminal half-life and accumulates in adipose tissue, which contributes to a long residence time of anacetrapib. Given our previous report that anacetrapib distributes into the lipid droplet of adipose tissue, we sought to understand whether anacetrapib affected adipose function, using a diet-induced obese (DIO) mouse model. Following 20 weeks of treatment with anacetrapib (100 mg/kg/day), levels of the drug increased to approximately 0.6 mmol/L in white adipose tissue. This level of anacetrapib was not associated with any impairment in adipose functionality as evidenced by a lack of any reduction in biomarkers of adipose functionality (plasma adiponectin, leptin, insulin; adipose adiponectin, leptin mRNA). In DIO wild-type (WT) mice treated with anacetrapib for 2 weeks and then subjected to 30% food restriction during washout to induce weight loss (18%) and fat mass loss (7%), levels of anacetrapib in adipose and plasma were not different between food restricted and ad lib-fed mice. These data indicate that despite deposition and long-term residence of ~0.6 mmol/L levels of anacetrapib in adipose tissue, adipose tissue function appears to be unaffected in mice. In addition, these data also indicate that even with severe caloric restriction and acute loss of fat mass, anacetrapib does not appear to be mobilized from the fat depot, thereby solidifying the role of adipose as a long-term storage site of anacetrapib. Copyright © 2019 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CETP protein, human). 0 (Cholesterol Ester Transfer Proteins). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Hypolipidemic Agents). 0 (Oxazolidinones). P7T269PR6S (anacetrapib).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fprp2.543
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Johns&issn=2052-1707&title=Pharmacology+Research+%26+Perspectives&atitle=Impact+of+drug+distribution+into+adipose+on+tissue+function%3A+The+cholesteryl+ester+transfer+protein+%28CETP%29+inhibitor+anacetrapib+as+a+test+case.&volume=7&issue=6&spage=e00543&epage=&date=2019&doi=10.1002%2Fprp2.543&pmid=31832204&sid=OVID:medline
+
+<1958>
+Unique Identifier
+ 31830996
+Title
+ Elevated MR-proANP plasma concentrations are associated with sepsis and predict mortality in critically ill patients.
+Source
+ Journal of Translational Medicine. 17(1):415, 2019 12 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yagmur E; Sckaer JH; Koek GH; Weiskirchen R; Trautwein C; Koch A; Tacke F
+Author NameID
+ Yagmur, Eray; ORCID: https://orcid.org/0000-0003-3328-2027
+ Weiskirchen, Ralf; ORCID: https://orcid.org/0000-0003-3888-0931
+ Koch, Alexander; ORCID: https://orcid.org/0000-0002-4452-4151
+ Tacke, Frank; ORCID: https://orcid.org/0000-0001-6206-0226
+Authors Full Name
+ Yagmur, Eray; Sckaer, Johanna Hermine; Koek, Ger H; Weiskirchen, Ralf; Trautwein, Christian; Koch, Alexander; Tacke, Frank.
+Institution
+ Yagmur, Eray. Medical Care Center, Dr. Stein and Colleagues, Tomphecke 45, 41169, Monchengladbach, Germany. eyagmur@ukaachen.de.
+ Sckaer, Johanna Hermine. Department of Medicine III, RWTH-University Hospital Aachen, Aachen, Germany.
+ Koek, Ger H. Section of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands.
+ Weiskirchen, Ralf. Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH-University Hospital Aachen, Aachen, Germany.
+ Trautwein, Christian. Department of Medicine III, RWTH-University Hospital Aachen, Aachen, Germany.
+ Koch, Alexander. Department of Medicine III, RWTH-University Hospital Aachen, Aachen, Germany.
+ Tacke, Frank. Department of Medicine III, RWTH-University Hospital Aachen, Aachen, Germany.
+ Tacke, Frank. Department of Hepatology and Gastroenterology, Charite University Medical Center, Berlin, Germany.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Case-Control Studies
+ Comorbidity
+ *Critical Illness/mo [Mortality]
+ Diabetes Mellitus/bl [Blood]
+ Female
+ Humans
+ Inflammation/bl [Blood]
+ Intensive Care Units
+ Male
+ Middle Aged
+ *Natriuretic Peptide, Brain/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/co [Complications]
+ ROC Curve
+ *Sepsis/bl [Blood]
+ Sepsis/co [Complications]
+ *Sepsis/mo [Mortality]
+ Young Adult
+Keyword Heading
+ Adipocytokines
+ Critical illness
+ Diabetes
+ ICU
+ Inflammation
+ MR-proANP
+ Metabolism
+ Mid-regional pro atrial natriuretic peptide
+ Obesity
+ Sepsis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: Mid-regional pro atrial natriuretic peptide (MR-proANP) is an established biomarker for heart failure, based on its key role in regulating homeostasis of water balance and blood pressure. The aim of the study was to determine the value of MR-proANP as a clinical biomarker in critical illness and/or sepsis. Upon admission to the medical intensive care unit (ICU), we investigated MR-proANP plasma concentrations in 217 critically ill patients (144 with sepsis, 73 without sepsis). Results were compared with 65 healthy controls.
+
+ RESULTS: MR-proANP plasma levels were significantly elevated in critically ill patients, when compared to healthy controls. Notably, MR-proANP levels were significantly higher in ICU patients with sepsis. MR-proANP levels were not associated with metabolic comorbidities like diabetes or obesity. In critically ill patients, MR-proANP plasma concentrations correlated with inflammatory cytokines, markers of organ dysfunction and several adipocytokines, such as resistin, retinol-binding protein 4 (RBP4) and adiponectin. Importantly, high MR-proANP plasma levels were associated with mortality, as MR-proANP levels above 227.0 pmol/l indicated a particularly increased mortality risk in ICU patients. The association between MR-proANP and mortality was independent of single organ failure and inflammation markers.
+
+ CONCLUSION: Our study emphasizes the role of circulating MR-proANP as a biomarker in critically ill patients, in which high MR-proANP indicates organ dysfunction, sepsis and mortality risk. The association between high MR-proANP and inflammatory as well as adipose tissue-derived endocrine mediators warrants further pathophysiological investigations.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12967-019-02165-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yagmur&issn=1479-5876&title=Journal+of+Translational+Medicine&atitle=Elevated+MR-proANP+plasma+concentrations+are+associated+with+sepsis+and+predict+mortality+in+critically+ill+patients.&volume=17&issue=1&spage=415&epage=&date=2019&doi=10.1186%2Fs12967-019-02165-2&pmid=31830996&sid=OVID:medline
+
+<1959>
+Unique Identifier
+ 31823717
+Title
+ Selection of microbial biomarkers with genetic algorithm and principal component analysis.
+Source
+ BMC Bioinformatics. 20(Suppl 6):413, 2019 Dec 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zhang P; West NP; Chen PY; Thang MWC; Price G; Cripps AW; Cox AJ
+Author NameID
+ Zhang, Ping; ORCID: http://orcid.org/0000-0002-3907-1127
+Authors Full Name
+ Zhang, Ping; West, Nicholas P; Chen, Pin-Yen; Thang, Mike W C; Price, Gareth; Cripps, Allan W; Cox, Amanda J.
+Institution
+ Zhang, Ping. Menzies Health Institute QLD, Griffith University, Gold Coast, Australia. p.zhang@griffith.edu.au.
+ West, Nicholas P. Menzies Health Institute QLD, Griffith University, Gold Coast, Australia.
+ West, Nicholas P. School of Medical Science, Griffith University, Gold Coast, Australia.
+ Chen, Pin-Yen. Menzies Health Institute QLD, Griffith University, Gold Coast, Australia.
+ Thang, Mike W C. QFAB Bioinformatics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
+ Price, Gareth. QFAB Bioinformatics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
+ Cripps, Allan W. Menzies Health Institute QLD, Griffith University, Gold Coast, Australia.
+ Cripps, Allan W. School of Medicine, Griffith University, Gold Coast, Australia.
+ Cox, Amanda J. School of Medical Science, Griffith University, Gold Coast, Australia.
+MeSH Subject Headings
+ *Algorithms
+ Bacteria/cl [Classification]
+ Bacteria/ge [Genetics]
+ Bacteria/me [Metabolism]
+ *Bacteria
+ Biomarkers
+ *Computational Biology/mt [Methods]
+ Humans
+ Obesity/mi [Microbiology]
+ *Principal Component Analysis/mt [Methods]
+Keyword Heading
+ Biomarker
+ Genetic algorithm
+ Obesity
+ PCA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Principal components analysis (PCA) is often used to find characteristic patterns associated with certain diseases by reducing variable numbers before a predictive model is built, particularly when some variables are correlated. Usually, the first two or three components from PCA are used to determine whether individuals can be clustered into two classification groups based on pre-determined criteria: control and disease group. However, a combination of other components may exist which better distinguish diseased individuals from healthy controls. Genetic algorithms (GAs) can be useful and efficient for searching the best combination of variables to build a prediction model. This study aimed to develop a prediction model that combines PCA and a genetic algorithm (GA) for identifying sets of bacterial species associated with obesity and metabolic syndrome (Mets).
+
+ RESULTS: The prediction models built using the combination of principal components (PCs) selected by GA were compared to the models built using the top PCs that explained the most variance in the sample and to models built with selected original variables. The advantages of combining PCA with GA were demonstrated.
+
+ CONCLUSIONS: The proposed algorithm overcomes the limitation of PCA for data analysis. It offers a new way to build prediction models that may improve the prediction accuracy. The variables included in the PCs that were selected by GA can be combined with flexibility for potential clinical applications. The algorithm can be useful for many biological studies where high dimensional data are collected with highly correlated variables.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12859-019-3001-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zhang&issn=1471-2105&title=BMC+Bioinformatics&atitle=Selection+of+microbial+biomarkers+with+genetic+algorithm+and+principal+component+analysis.&volume=20&issue=6&spage=413&epage=&date=2019&doi=10.1186%2Fs12859-019-3001-4&pmid=31823717&sid=OVID:medline
+
+<1960>
+Unique Identifier
+ 31823713
+Title
+ A correlation-based network for biomarker discovery in obesity with metabolic syndrome.
+Source
+ BMC Bioinformatics. 20(Suppl 6):477, 2019 Dec 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chen PY; Cripps AW; West NP; Cox AJ; Zhang P
+Author NameID
+ Chen, Pin-Yen; ORCID: http://orcid.org/0000-0002-2187-6939
+Authors Full Name
+ Chen, Pin-Yen; Cripps, Allan W; West, Nicholas P; Cox, Amanda J; Zhang, Ping.
+Institution
+ Chen, Pin-Yen. Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia. pin-yenfiona.chen@griffithuni.edu.au.
+ Chen, Pin-Yen. School of Medical Science, Griffith University, Gold Coast, Australia. pin-yenfiona.chen@griffithuni.edu.au.
+ Cripps, Allan W. Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
+ Cripps, Allan W. School of Medicine, Griffith University, Gold Coast, Australia.
+ West, Nicholas P. Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
+ West, Nicholas P. School of Medical Science, Griffith University, Gold Coast, Australia.
+ Cox, Amanda J. School of Medical Science, Griffith University, Gold Coast, Australia.
+ Zhang, Ping. Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Biomarkers/me [Metabolism]
+ *Biomarkers
+ Computational Biology
+ Female
+ Humans
+ Male
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/me [Metabolism]
+ *Metabolic Syndrome
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ *Obesity
+Keyword Heading
+ Gut microbiome
+ Immune system
+ Inflammation
+ Metabolic syndrome
+ Multidimensional data
+ Multivariate analysis
+ Network analysis
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is associated with chronic activation of the immune system and an altered gut microbiome, leading to increased risk of chronic disease development. As yet, no biomarker profile has been found to distinguish individuals at greater risk of obesity-related disease. The aim of this study was to explore a correlation-based network approach to identify existing patterns of immune-microbiome interactions in obesity.
+
+ RESULTS: The current study performed correlation-based network analysis on five different datasets obtained from 11 obese with metabolic syndrome (MetS) and 12 healthy weight men. These datasets included: anthropometric measures, metabolic measures, immune cell abundance, serum cytokine concentration, and gut microbial composition. The obese with MetS group had a denser network (total number of edges, n = 369) compared to the healthy network (n = 299). Within the obese with MetS network, biomarkers from the immune cell abundance group was found to be correlated to biomarkers from all four other datasets. Conversely in the healthy network, immune cell abundance was only correlated with serum cytokine concentration and gut microbial composition. These observations suggest high involvement of immune cells in obese with MetS individuals. There were also three key hubs found among immune cells in the obese with MetS networks involving regulatory T cells, neutrophil and cytotoxic cell abundance. No hubs were present in the healthy network.
+
+ CONCLUSION: These results suggest a more complex interaction of inflammatory markers in obesity, with high connectivity of immune cells in the obese with MetS network compared to the healthy network. Three key hubs were identified in the obese with MetS network, involving Treg, neutrophils and cytotoxic cell abundance. Compared to a t-test, the network approach offered more meaningful results when comparing obese with MetS and healthy weight individuals, demonstrating its superiority in exploratory analysis.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12859-019-3064-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chen&issn=1471-2105&title=BMC+Bioinformatics&atitle=A+correlation-based+network+for+biomarker+discovery+in+obesity+with+metabolic+syndrome.&volume=20&issue=6&spage=477&epage=&date=2019&doi=10.1186%2Fs12859-019-3064-2&pmid=31823713&sid=OVID:medline
+
+<1961>
+Unique Identifier
+ 31822763
+Title
+ Obesity is associated with shorter telomeres in 8 year-old children.
+Source
+ Scientific Reports. 9(1):18739, 2019 12 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Clemente DBP; Maitre L; Bustamante M; Chatzi L; Roumeliotaki T; Fossati S; Grazuleviciene R; Gutzkow KB; Lepeule J; Martens DS; McEachan RRC; Meltzer HM; Petraviciene I; Slama R; Tamayo-Uria I; Urquiza J; Vafeiadi M; Wright J; Nawrot TS; Vrijheid M
+Author NameID
+ Clemente, Diana B P; ORCID: http://orcid.org/0000-0002-8636-5304
+ Maitre, Lea; ORCID: http://orcid.org/0000-0003-3682-7117
+ Fossati, Serena; ORCID: http://orcid.org/0000-0002-7484-5837
+ Lepeule, Johanna; ORCID: http://orcid.org/0000-0001-8907-197X
+ Martens, Dries S; ORCID: http://orcid.org/0000-0001-7893-3642
+Authors Full Name
+ Clemente, Diana B P; Maitre, Lea; Bustamante, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Grazuleviciene, Regina; Gutzkow, Kristine B; Lepeule, Johanna; Martens, Dries S; McEachan, Rosie R C; Meltzer, Helle M; Petraviciene, Inga; Slama, Remy; Tamayo-Uria, Ibon; Urquiza, Jose; Vafeiadi, Marina; Wright, John; Nawrot, Tim S; Vrijheid, Martine.
+Institution
+ Clemente, Diana B P. ISGlobal, Institute for Global Health Barcelona, C/ Doctor Aiguader 88, 08003, Barcelona, Spain.
+ Clemente, Diana B P. Center for Environmental Sciences, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
+ Clemente, Diana B P. Universitat Pompeu Fabra, Placa de la Merce, 10, 08002, Barcelona, Spain.
+ Clemente, Diana B P. CIBER Epidemiologia y Salud Publica (CIBERESP), Av. Monforte de Lemos, 3-5, Madrid, Spain.
+ Maitre, Lea. ISGlobal, Institute for Global Health Barcelona, C/ Doctor Aiguader 88, 08003, Barcelona, Spain.
+ Maitre, Lea. Universitat Pompeu Fabra, Placa de la Merce, 10, 08002, Barcelona, Spain.
+ Maitre, Lea. CIBER Epidemiologia y Salud Publica (CIBERESP), Av. Monforte de Lemos, 3-5, Madrid, Spain.
+ Bustamante, Mariona. ISGlobal, Institute for Global Health Barcelona, C/ Doctor Aiguader 88, 08003, Barcelona, Spain.
+ Bustamante, Mariona. Universitat Pompeu Fabra, Placa de la Merce, 10, 08002, Barcelona, Spain.
+ Bustamante, Mariona. CIBER Epidemiologia y Salud Publica (CIBERESP), Av. Monforte de Lemos, 3-5, Madrid, Spain.
+ Bustamante, Mariona. Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), C/ Doctor Aiguader 88, 08003, Barcelona, Spain.
+ Chatzi, Leda. Department of Preventive Medicine, University of Southern California, University Park Campus, 90089-0911, Los Angeles, USA.
+ Chatzi, Leda. Department of Social Medicine, University of Crete, Andrea Kalokerinou 13, 715 00, Crete, Greece.
+ Roumeliotaki, Theano. Department of Social Medicine, University of Crete, Andrea Kalokerinou 13, 715 00, Crete, Greece.
+ Fossati, Serena. ISGlobal, Institute for Global Health Barcelona, C/ Doctor Aiguader 88, 08003, Barcelona, Spain.
+ Fossati, Serena. Universitat Pompeu Fabra, Placa de la Merce, 10, 08002, Barcelona, Spain.
+ Fossati, Serena. CIBER Epidemiologia y Salud Publica (CIBERESP), Av. Monforte de Lemos, 3-5, Madrid, Spain.
+ Grazuleviciene, Regina. Department of Environmental Science, Vytautas Magnus University, Donelaicio 58, 44248, Kaunas, Lithuania.
+ Gutzkow, Kristine B. Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, NO-0403, Oslo, Norway.
+ Lepeule, Johanna. Inserm and University Grenoble-Alpes, U1209, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, 110 Rue de la Chimie, 38400, Saint-Martin-d'Heres, France.
+ Martens, Dries S. Center for Environmental Sciences, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
+ McEachan, Rosie R C. Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, BD9 6RJ, Bradford, UK.
+ Meltzer, Helle M. Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, NO-0403, Oslo, Norway.
+ Petraviciene, Inga. Department of Environmental Science, Vytautas Magnus University, Donelaicio 58, 44248, Kaunas, Lithuania.
+ Slama, Remy. Inserm and University Grenoble-Alpes, U1209, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, 110 Rue de la Chimie, 38400, Saint-Martin-d'Heres, France.
+ Tamayo-Uria, Ibon. ISGlobal, Institute for Global Health Barcelona, C/ Doctor Aiguader 88, 08003, Barcelona, Spain.
+ Tamayo-Uria, Ibon. Center for Environmental Sciences, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
+ Tamayo-Uria, Ibon. Universitat Pompeu Fabra, Placa de la Merce, 10, 08002, Barcelona, Spain.
+ Tamayo-Uria, Ibon. Department of Statistics, Faculty of Arts and Sciences, Harvard University, Cambridge, 02138, Massachusetts, USA.
+ Urquiza, Jose. ISGlobal, Institute for Global Health Barcelona, C/ Doctor Aiguader 88, 08003, Barcelona, Spain.
+ Urquiza, Jose. Universitat Pompeu Fabra, Placa de la Merce, 10, 08002, Barcelona, Spain.
+ Urquiza, Jose. CIBER Epidemiologia y Salud Publica (CIBERESP), Av. Monforte de Lemos, 3-5, Madrid, Spain.
+ Vafeiadi, Marina. Department of Social Medicine, University of Crete, Andrea Kalokerinou 13, 715 00, Crete, Greece.
+ Wright, John. Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, BD9 6RJ, Bradford, UK.
+ Nawrot, Tim S. Center for Environmental Sciences, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
+ Nawrot, Tim S. Department of Public Health & Primary Care, Unit Environment & Health, Leuven University, Oude Markt 13, 3000, Leuven, Belgium.
+ Vrijheid, Martine. ISGlobal, Institute for Global Health Barcelona, C/ Doctor Aiguader 88, 08003, Barcelona, Spain. martine.vrijheid@isglobal.org.
+ Vrijheid, Martine. Universitat Pompeu Fabra, Placa de la Merce, 10, 08002, Barcelona, Spain. martine.vrijheid@isglobal.org.
+ Vrijheid, Martine. CIBER Epidemiologia y Salud Publica (CIBERESP), Av. Monforte de Lemos, 3-5, Madrid, Spain. martine.vrijheid@isglobal.org.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ *Aging/ge [Genetics]
+ Aging/ph [Physiology]
+ Biomarkers
+ Body Mass Index
+ Child
+ Cohort Studies
+ Female
+ Humans
+ Male
+ *Obesity/ge [Genetics]
+ Pregnancy
+ Retrospective Studies
+ Risk Factors
+ Skinfold Thickness
+ *Telomere/ge [Genetics]
+ Telomere/me [Metabolism]
+ Telomere Shortening/ge [Genetics]
+ Telomere Shortening/ph [Physiology]
+ Waist Circumference
+Abstract
+ Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte telomere length (LTL) in childhood, data from 1,396 mother-child pairs of the multi-centre European birth cohort study HELIX were used. Maternal pre-pregnancy body mass index (BMI) and 4 adiposity markers in children at age 8 (6-11) years were assessed: BMI, fat mass, waist circumference, and skinfold thickness. Relative LTL was obtained. Associations of LTL with each adiposity marker were calculated using linear mixed models with a random cohort effect. For each 1 kg/m2 increment in maternal pre-pregnancy BMI, the child's LTL was 0.23% shorter (95%CI: 0.01,0.46%). Each unit increase in child BMI z-score was associated with 1.21% (95%CI: 0.30,2.11%) shorter LTL. Inverse associations were observed between waist circumference and LTL (-0.96% per z-score unit; 95%CI: -2.06,0.16%), and skinfold thickness and LTL (-0.10% per z-score unit; 95%CI: -0.23,0.02%). In conclusion, this large multicentric study suggests that higher child adiposity indicators are associated with short telomeres in children, and that associations are stronger for child BMI than for maternal pre-pregnancy BMI.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-55283-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Clemente&issn=2045-2322&title=Scientific+Reports&atitle=Obesity+is+associated+with+shorter+telomeres+in+8+year-old+children.&volume=9&issue=1&spage=18739&epage=&date=2019&doi=10.1038%2Fs41598-019-55283-8&pmid=31822763&sid=OVID:medline
+
+<1962>
+Unique Identifier
+ 31817583
+Title
+ Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis. [Review]
+Source
+ Cells. 8(12), 2019 12 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Manoel Alves J; Handerson Gomes Teles R; do Valle Gomes Gatto C; Munoz VR; Regina Cominetti M; Garcia de Oliveira Duarte AC
+Author NameID
+ Manoel Alves, Joao; ORCID: https://orcid.org/0000-0002-6876-6593
+ Munoz, Vitor Rosetto; ORCID: https://orcid.org/0000-0003-4280-6558
+ Regina Cominetti, Marcia; ORCID: https://orcid.org/0000-0001-6385-7392
+ Garcia de Oliveira Duarte, Ana Claudia; ORCID: https://orcid.org/0000-0002-7667-9481
+Authors Full Name
+ Manoel Alves, Joao; Handerson Gomes Teles, Ramon; do Valle Gomes Gatto, Camila; Munoz, Vitor Rosetto; Regina Cominetti, Marcia; Garcia de Oliveira Duarte, Ana Claudia.
+Institution
+ Manoel Alves, Joao. Department of Physical Education, Federal University of Sao Carlos (UFSCar), Sao Carlos 13565-905, SP, Brazil.
+ Handerson Gomes Teles, Ramon. Department of Gerontology, Federal University of Sao Carlos (UFSCar), Sao Carlos 13565-905, SP, Brazil.
+ do Valle Gomes Gatto, Camila. Laboratory of Biochemistry and Molecular Biology of Exercise, University of Sao Paulo (USP), Sao Paulo 05508-030, SP, Brazil.
+ Munoz, Vitor Rosetto. Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira 13484-350, SP, Brazil.
+ Regina Cominetti, Marcia. Department of Gerontology, Federal University of Sao Carlos (UFSCar), Sao Carlos 13565-905, SP, Brazil.
+ Garcia de Oliveira Duarte, Ana Claudia. Department of Physical Education, Federal University of Sao Carlos (UFSCar), Sao Carlos 13565-905, SP, Brazil.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ *Bibliometrics
+ Biomarkers
+ Computational Biology/mt [Methods]
+ *Disease Susceptibility
+ Gene Expression Profiling
+ Gene Expression Regulation
+ Humans
+ *MicroRNAs/ge [Genetics]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+Keyword Heading
+ adipogenesis
+ adipose tissue
+ bibliometric analysis
+ microRNA
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Recent studies have investigated the control of adipose tissue expansion and inflammatory process by microRNAs (miRNAs). These two processes are of great interest because both are associated with obesity and metabolic syndrome. However, despite the great relevance of the role of miRNAs in obesity and adipose tissue, no qualitative and quantitative analysis on the subject has been performed. Thus, we aimed to examine global research activity and current trends with respect to the interaction between obesity, adipose tissue and miRNAs through a bibliometric analysis. This research was performed on the Scopus database for publications containing miRNA, obesity, and adipose tissue keyword combinations. In total, 898 articles were analyzed and the most frequently occurring keywords were selected and clustered into three well-defined groups. As a result, first group of keywords pointed to the research area on miRNAs expressed in obesity-associated diseases. The second group demonstrated the regulation of the adipogenesis process by miRNAs, while the third group highlighted brown adipose tissue and thermogenesis as one of the latest global research trends related to the theme. The studies selected in this paper describe the expression and performance of different miRNAs in obesity and comorbidities. Most studies have focused on identifying miRNAs and signaling pathways associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Thus, the miRNA profile for these diseases may be used as biomarkers and therapeutic targets in the prevention and treatment of obesity-associated diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fcells8121581
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Manoel+Alves&issn=2073-4409&title=Cells&atitle=Mapping+Research+in+the+Obesity%2C+Adipose+Tissue%2C+and+MicroRNA+Field%3A+A+Bibliometric+Analysis.&volume=8&issue=12&spage=&epage=&date=2019&doi=10.3390%2Fcells8121581&pmid=31817583&sid=OVID:medline
+
+<1963>
+Unique Identifier
+ 31810342
+Title
+ Effectiveness of Individual Nutrition Education Compared to Group Education, in Improving Anthropometric and Biochemical Indices among Hypertensive Adults with Excessive Body Weight: A Randomized Controlled Trial.
+Source
+ Nutrients. 11(12), 2019 Dec 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gajewska D; Kucharska A; Kozak M; Wunderlich S; Niegowska J
+Authors Full Name
+ Gajewska, Danuta; Kucharska, Alicja; Kozak, Marcin; Wunderlich, Shahla; Niegowska, Joanna.
+Institution
+ Gajewska, Danuta. Department of Dietetics, Faculty of Human Nutrition, Warsaw University of Life Sciences - SGGW (WULS), 159C Nowoursynowska Str, 02-776 Warsaw, Poland.
+ Kucharska, Alicja. Human Nutrition Department, Warsaw Medical University, 02-776 Warsaw, Poland.
+ Kozak, Marcin. Department of Botany, Warsaw University of Life Sciences - SGGW (WULS), 159C Nowoursynowska Str, 02-776 Warsaw, Poland.
+ Wunderlich, Shahla. Department of Nutrition and Food Studies, Montclair State University, 1 Normal Avenue Montclair, Montclair, NJ 07043, USA.
+ Niegowska, Joanna. Department of Dietetics, Faculty of Human Nutrition, Warsaw University of Life Sciences - SGGW (WULS), 159C Nowoursynowska Str, 02-776 Warsaw, Poland.
+MeSH Subject Headings
+ Adult
+ Anthropometry
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Dietetics/mt [Methods]
+ Female
+ Humans
+ Hypertension/co [Complications]
+ *Hypertension/th [Therapy]
+ Male
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/th [Therapy]
+ Overweight/co [Complications]
+ *Overweight/th [Therapy]
+ *Patient Education as Topic/mt [Methods]
+ *Precision Medicine/mt [Methods]
+ *Psychotherapy, Group/mt [Methods]
+ Treatment Outcome
+Keyword Heading
+ group nutrition education
+ hypertension
+ individual nutrition education
+ obesity
+ overweight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The study aims to compare the effectiveness of individual and group nutrition education methods in improving key anthropometric and biochemical markers in drug-treated, overweight-obese hypertensive adults.
+
+ METHODS: The randomized trial included 170 patients with pharmacologically well-controlled primary hypertension and body mass index (BMI) >= 25 kg/m2. For six months, the patients received six sessions, either one-to-one individual nutrition education (IE, n = 89) or group education (GE, n = 81), developed by dietitians. Anthropometric measurements, body composition, and fasting measures of biochemical parameters were obtained at baseline and after six months of intervention.
+
+ RESULTS: 150 patients completed the nutrition education program. The IE group significantly improved in many parameters compared to the GE group, including weight (p < 0.001), waist circumference (p < 0.001), BMI (p < 0.001), systolic and diastolic blood pressure (BP) (p < 0.001), fasting plasma glucose (p = 0.011), oral glucose tolerance test (OGGT) (p = 0.030), and insulin resistance (homeostatic model assessment of insulin resistance, HOMA-IR) (p < 0.001). The groups did not differ in terms of total cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) concentrations.
+
+ CONCLUSION: Individual nutrition education is more effective than group education in terms of improving anthropometric and biochemical indices in overweight-obese hypertensive adults.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11122921
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gajewska&issn=2072-6643&title=Nutrients&atitle=Effectiveness+of+Individual+Nutrition+Education+Compared+to+Group+Education%2C+in+Improving+Anthropometric+and+Biochemical+Indices+among+Hypertensive+Adults+with+Excessive+Body+Weight%3A+A+Randomized+Controlled+Trial.&volume=11&issue=12&spage=&epage=&date=2019&doi=10.3390%2Fnu11122921&pmid=31810342&sid=OVID:medline
+
+<1964>
+Unique Identifier
+ 31798902
+Title
+ Plasma fibroblast growth factor 21 levels increase with ectopic fat accumulation and its receptor levels are decreased in the visceral fat of patients with type 2 diabetes.
+Source
+ BMJ Open Diabetes Research & Care. 7(1):e000776, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hong ES; Lim C; Choi HY; Lee YK; Ku EJ; Moon JH; Park KS; Jang HC; Choi SH
+Author NameID
+ Ku, Eu Jeong; ORCID: https://orcid.org/0000-0001-5533-4989
+ Jang, Hak Chul; ORCID: https://orcid.org/0000-0002-4188-6536
+ Choi, Sung Hee; ORCID: https://orcid.org/0000-0003-0740-8116
+Authors Full Name
+ Hong, Eun Shil; Lim, Cheong; Choi, Hye Yeon; Lee, Yun Kyung; Ku, Eu Jeong; Moon, Jae Hoon; Park, Kyong Soo; Jang, Hak Chul; Choi, Sung Hee.
+Institution
+ Hong, Eun Shil. Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, South Korea.
+ Hong, Eun Shil. Internal Medicine, Konkuk University Chungju Hospital, Chungju, South Korea.
+ Lim, Cheong. Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, South Korea.
+ Lim, Cheong. Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.
+ Choi, Hye Yeon. Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
+ Lee, Yun Kyung. Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
+ Ku, Eu Jeong. Internal Medicine, Chungbuk National University Hospital, Cheongju, South Korea.
+ Moon, Jae Hoon. Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
+ Moon, Jae Hoon. Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
+ Park, Kyong Soo. Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
+ Jang, Hak Chul. Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
+ Jang, Hak Chul. Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
+ Choi, Sung Hee. Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
+ Choi, Sung Hee. Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
+MeSH Subject Headings
+ *Adipose Tissue/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Case-Control Studies
+ China/ep [Epidemiology]
+ Cohort Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ *Fibroblast Growth Factors/bl [Blood]
+ Follow-Up Studies
+ Humans
+ Incidence
+ Insulin Resistance
+ *Intra-Abdominal Fat/pp [Physiopathology]
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prediabetic State/bl [Blood]
+ Prediabetic State/ep [Epidemiology]
+ Prognosis
+ *Receptors, Fibroblast Growth Factor/bl [Blood]
+ Signal Transduction
+Keyword Heading
+ adipocytokine
+ body fat distribution
+ insulin resistance
+ type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that has beneficial effects on glucose and lipid metabolism. However, plasma FGF21 levels are paradoxically increased in type 2 diabetes mellitus (T2DM) and obesity, suggesting resistance to this ligand. FGF21 acts mainly on adipose tissue and ectopic fat accumulation is a typical feature in metabolic deterioration such as diabetes, metabolic syndrome, and cardiovascular disease.
+
+ Objective: To investigate the relationship between FGF21 resistance and ectopic fat accumulation.
+
+ Research design and methods: Subjects who underwent 64-slice multidetector CT (MDCT) were enrolled (n=190). Plasma FGF21 levels and MDCT data of ectopic fats at various sites were analyzed. Human visceral and subcutaneous fat tissues from abdominal and coronary artery bypass surgery were obtained. FGF21 receptor expression and postreceptor signaling in different fat deposits of both control and T2DM subjects were analyzed.
+
+ Results: Plasma FGF21 levels were significantly associated with body mass index, triglyceride, homeostatic model assessment of insulin resistance, and Matsuda index. Plasma FGF21 levels were significantly higher in patients with T2DM than in the pre-diabetes and normal glucose tolerance groups. The ectopic fat phenotypes (visceral, epicardial, intrahepatic, and intramuscular fat) of T2DM were significantly higher than controls. Plasma FGF21 levels were elevated and exhibited a strong positive correlation with ectopic fat accumulation in T2DM. The expression of genes comprising the FGF21 signaling pathway was also lower in visceral fat than in subcutaneous fat in this disease.
+
+ Conclusions: Human FGF21 resistance in T2DM could result from increases in FGF21-resistant ectopic fat accumulation. Our study provides novel clinical evidence linking FGF21 resistance and T2DM pathogenesis. Copyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FGF21 protein, human). 0 (Receptors, Fibroblast Growth Factor). 62031-54-3 (Fibroblast Growth Factors).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1136%2fbmjdrc-2019-000776
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hong&issn=2052-4897&title=BMJ+Open+Diabetes+Research+%26+Care&atitle=Plasma+fibroblast+growth+factor+21+levels+increase+with+ectopic+fat+accumulation+and+its+receptor+levels+are+decreased+in+the+visceral+fat+of+patients+with+type+2+diabetes.&volume=7&issue=1&spage=e000776&epage=&date=2019&doi=10.1136%2Fbmjdrc-2019-000776&pmid=31798902&sid=OVID:medline
+
+<1965>
+Unique Identifier
+ 31795496
+Title
+ Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins. [Review]
+Source
+ Cells. 8(12), 2019 11 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Inoue MK; Nakatsu Y; Yamamotoya T; Hasei S; Kanamoto M; Naitou M; Matsunaga Y; Sakoda H; Fujishiro M; Ono H; Kushiyama A; Asano T
+Authors Full Name
+ Inoue, Masa-Ki; Nakatsu, Yusuke; Yamamotoya, Takeshi; Hasei, Shun; Kanamoto, Mayu; Naitou, Miki; Matsunaga, Yasuka; Sakoda, Hideyuki; Fujishiro, Midori; Ono, Hiraku; Kushiyama, Akifumi; Asano, Tomoichiro.
+Institution
+ Inoue, Masa-Ki. Department of Medical Science, Graduate School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minamitnf-ku, Hiroshima City, Hiroshima 734-8551, Japan.
+ Nakatsu, Yusuke. Department of Medical Science, Graduate School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minamitnf-ku, Hiroshima City, Hiroshima 734-8551, Japan.
+ Yamamotoya, Takeshi. Department of Medical Science, Graduate School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minamitnf-ku, Hiroshima City, Hiroshima 734-8551, Japan.
+ Hasei, Shun. Department of Medical Science, Graduate School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minamitnf-ku, Hiroshima City, Hiroshima 734-8551, Japan.
+ Kanamoto, Mayu. Department of Medical Science, Graduate School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minamitnf-ku, Hiroshima City, Hiroshima 734-8551, Japan.
+ Naitou, Miki. Department of Medical Science, Graduate School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minamitnf-ku, Hiroshima City, Hiroshima 734-8551, Japan.
+ Matsunaga, Yasuka. Center for Translational Research in Infection & Inflammation, School of Medicine, Tulane University, 6823 St. Charles Avenue, New Orleans, LA 70118, USA.
+ Sakoda, Hideyuki. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
+ Fujishiro, Midori. Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, Japan.
+ Ono, Hiraku. Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
+ Kushiyama, Akifumi. Department of Pharmacotherapy, Meiji Pharmaceutical University 2-522-1 Noshio Kiyose, Tokyo 204-8588, Japan.
+ Asano, Tomoichiro. Department of Medical Science, Graduate School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minamitnf-ku, Hiroshima City, Hiroshima 734-8551, Japan.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ *Biomarkers
+ *Disease Susceptibility
+ Genetic Predisposition to Disease
+ Humans
+ Isoenzymes
+ Lipid Metabolism
+ Liver Cirrhosis/et [Etiology]
+ Liver Cirrhosis/me [Metabolism]
+ Liver Cirrhosis/pa [Pathology]
+ NADPH Oxidases/me [Metabolism]
+ *NIMA-Interacting Peptidylprolyl Isomerase/ge [Genetics]
+ *NIMA-Interacting Peptidylprolyl Isomerase/me [Metabolism]
+ *Non-alcoholic Fatty Liver Disease/et [Etiology]
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Non-alcoholic Fatty Liver Disease/pa [Pathology]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Reactive Oxygen Species/me [Metabolism]
+Keyword Heading
+ NAFLD
+ NASH
+ Pin1
+ fibrosis
+ inflammation
+ lipid
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Pin1 is one of the three known prolyl-isomerase types and its hepatic expression level is markedly enhanced in the obese state. Pin1 plays critical roles in favoring the exacerbation of both lipid accumulation and fibrotic change accompanying inflammation. Indeed, Pin1-deficient mice are highly resistant to non-alcoholic steatohepatitis (NASH) development by either a high-fat diet or methionine-choline-deficient diet feeding. The processes of NASH development can basically be separated into lipid accumulation and subsequent fibrotic change with inflammation. In this review, we outline the molecular mechanisms by which increased Pin1 promotes both of these phases of NASH. The target proteins of Pin1 involved in lipid accumulation include insulin receptor substrate 1 (IRS-1), AMP-activated protein kinase (AMPK) and acetyl CoA carboxylase 1 (ACC1), while the p60 of the NF-kB complex and transforming growth factor beta (TGF-beta) pathway appear to be involved in the fibrotic process accelerated by Pin1. Interestingly, Pin1 deficiency does not cause abnormalities in liver size, appearance or function. Therefore, we consider the inhibition of increased Pin1 to be a promising approach to treating NASH and preventing hepatic fibrosis.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Isoenzymes). 0 (NIMA-Interacting Peptidylprolyl Isomerase). 0 (Reactive Oxygen Species). EC 1-6-3 (NADPH Oxidases).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fcells8121545
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Inoue&issn=2073-4409&title=Cells&atitle=Pin1+Plays+Essential+Roles+in+NASH+Development+by+Modulating+Multiple+Target+Proteins.&volume=8&issue=12&spage=&epage=&date=2019&doi=10.3390%2Fcells8121545&pmid=31795496&sid=OVID:medline
+
+<1966>
+Unique Identifier
+ 31795194
+Title
+ MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States. [Review]
+Source
+ Cells. 8(12), 2019 11 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Vasu S; Kumano K; Darden CM; Rahman I; Lawrence MC; Naziruddin B
+Authors Full Name
+ Vasu, Srividya; Kumano, Kenjiro; Darden, Carly M; Rahman, Irum; Lawrence, Michael C; Naziruddin, Bashoo.
+Institution
+ Vasu, Srividya. Islet Cell Laboratory, Baylor Scott and White Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
+ Kumano, Kenjiro. Islet Cell Laboratory, Baylor Scott and White Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
+ Darden, Carly M. Islet Cell Laboratory, Baylor Scott and White Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
+ Darden, Carly M. Department of Biomedical Studies, Baylor University, 1301 S. University Parks Dr., Waco, TX 75706, USA.
+ Rahman, Irum. Islet Cell Laboratory, Baylor Scott and White Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
+ Lawrence, Michael C. Islet Cell Laboratory, Baylor Scott and White Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
+ Naziruddin, Bashoo. Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, 3410 Worth St., Suite 950, Dallas, TX 75246, USA.
+MeSH Subject Headings
+ Animals
+ *Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 1/di [Diagnosis]
+ Diabetes Mellitus, Type 1/me [Metabolism]
+ *Diabetes Mellitus, Type 2/di [Diagnosis]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ *Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/me [Metabolism]
+ Early Diagnosis
+ Female
+ Humans
+ Mice
+ *MicroRNAs/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Pregnancy
+Keyword Heading
+ biomarker
+ diabetes
+ islet
+ miRNA
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Diabetes results from the inability of pancreatic islets to maintain blood glucose concentrations within a normal physiological range. Clinical features are usually not observed until islets begin to fail and irreversible damage has occurred. Diabetes is generally diagnosed based on elevated glucose, which does not distinguish between type 1 and 2 diabetes. Thus, new diagnostic approaches are needed to detect different modes of diabetes before manifestation of disease. During prediabetes (pre-DM), islets undergo stress and release micro (mi) RNAs. Here, we review studies that have measured and tracked miRNAs in the blood for those with recent-onset or longstanding type 1 diabetes, obesity, pre-diabetes, type 2 diabetes, and gestational diabetes. We summarize the findings on miRNA signatures with the potential to stage progression of different modes of diabetes. Advances in identifying selective biomarker signatures may aid in early detection and classification of diabetic conditions and treatments to prevent and reverse diabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MicroRNAs).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fcells8121533
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Vasu&issn=2073-4409&title=Cells&atitle=MicroRNA+Signatures+as+Future+Biomarkers+for+Diagnosis+of+Diabetes+States.&volume=8&issue=12&spage=&epage=&date=2019&doi=10.3390%2Fcells8121533&pmid=31795194&sid=OVID:medline
+
+<1967>
+Unique Identifier
+ 31794594
+Title
+ Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM.
+Source
+ PLoS ONE [Electronic Resource]. 14(12):e0225978, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yen IW; Lee CN; Lin MW; Fan KC; Wei JN; Chen KY; Chen SC; Tai YY; Kuo CH; Lin CH; Hsu CY; Chuang LM; Lin SY; Li HY
+Authors Full Name
+ Yen, I-Weng; Lee, Chien-Nan; Lin, Ming-Wei; Fan, Kang-Chih; Wei, Jung-Nan; Chen, Kuan-Yu; Chen, Szu-Chi; Tai, Yi-Yun; Kuo, Chun-Heng; Lin, Chia-Hung; Hsu, Chih-Yao; Chuang, Lee-Ming; Lin, Shin-Yu; Li, Hung-Yuan.
+Institution
+ Yen, I-Weng. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
+ Lee, Chien-Nan. Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
+ Lin, Ming-Wei. Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
+ Fan, Kang-Chih. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
+ Wei, Jung-Nan. Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
+ Chen, Kuan-Yu. Ansn Clinic, Hsin-Chu, Taiwan.
+ Chen, Szu-Chi. Department of Internal Medicine, Cardinal Tien Hospital, New Taipei City, Taiwan.
+ Tai, Yi-Yun. Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
+ Kuo, Chun-Heng. Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City, Taiwan.
+ Lin, Chia-Hung. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
+ Hsu, Chih-Yao. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
+ Chuang, Lee-Ming. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
+ Lin, Shin-Yu. Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
+ Li, Hung-Yuan. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ *Diabetes, Gestational/ep [Epidemiology]
+ *Diabetes, Gestational/et [Etiology]
+ Disease Susceptibility
+ *Energy Metabolism
+ Female
+ Gestational Age
+ Humans
+ *Obesity/co [Complications]
+ *Obesity/ep [Epidemiology]
+ Obesity/me [Metabolism]
+ *Overweight/co [Complications]
+ *Overweight/ep [Epidemiology]
+ Overweight/me [Metabolism]
+ Pregnancy
+ Risk Assessment
+ Risk Factors
+ Young Adult
+Abstract
+ AIM: Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study.
+
+ METHODS: Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index >=24 kg/m2. GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24-28 gestational weeks.
+
+ RESULTS: Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p<0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p <0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women.
+
+ CONCLUSIONS: Overweight/obesity is associated with clustering of metabolic risk factors in early pregnancy, which is correlated with higher risk of GDM. Our findings suggest that metabolic risk factors during early pregnancy should be evaluated in overweight/obese women.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0225978
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yen&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Overweight+and+obesity+are+associated+with+clustering+of+metabolic+risk+factors+in+early+pregnancy+and+the+risk+of+GDM.&volume=14&issue=12&spage=e0225978&epage=&date=2019&doi=10.1371%2Fjournal.pone.0225978&pmid=31794594&sid=OVID:medline
+
+<1968>
+Unique Identifier
+ 31793264
+Title
+ Diabetes Risk Diagnosis Using Obesity Markers and Glycemic Control in Indian Population.
+Source
+ Journal of the Association of Physicians of India. 67(11):22-24, 2019 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rohit S; Rahul M
+Authors Full Name
+ Rohit, Sane; Rahul, Mandole.
+Institution
+ Rohit, Sane. Madhav Baug Cardiac Care Clinic, Thane, Maharashtra, Corresponding Author.
+ Rahul, Mandole. Madhav Baug Cardiac Care Clinic, Thane, Maharashtra.
+MeSH Subject Headings
+ Biomarkers
+ *Blood Glucose
+ Body Mass Index
+ Diabetes Mellitus/di [Diagnosis]
+ *Diabetes Mellitus
+ Glycated Hemoglobin
+ Humans
+ India
+ Middle Aged
+ Obesity/co [Complications]
+ Obesity/di [Diagnosis]
+ *Obesity
+Abstract
+ STATEMENT OF THE PROBLEM: It is important to note, liver and pancreas are majorly responsible for normal glucose metabolism, these organs are located centrally hence central obesity/abdominal distension will affect glycaemic control more than generalise obesity. Scientific literature highlights a strong and consistent relation between abdominal girth and diabetes risk. Haemoglobin A1c (HbA1c) is recognized as a diagnostic test for DM as well as for its monitoring.
+
+ AIM: The purpose of this study is to assess association of anthropometric markers viz. Body mass index (BMI) and abdominal girth (AG) for prediction of glycaemic control in Indian population.
+
+ METHODS: This single centre observational study was carried out from Feb 2015 to Oct 2015 at Khopoli, Maharashtra. Participants of both gender, andgt;20 yrs and willing to screen for HbA1c and anthropometry were included.
+
+ FINDINGS: Out of the 2640 participants who visited the centre, 1870 (N=860 non-DM, age median (range): 57 (48/65) and N=1010 DM, age: 60 (53/65)) were enrolled in this study. HbA1c levels were statistically significantly elevated in DM vs. non-DM group (median (range): 7.5 (6.5/8.9) vs. 5.7 (5.2/6.3); p=0.000). Interestingly, abdominal girth showed significant difference between DM and non-DM groups (median (range): 95 (88/102) vs. 93 (86/100); p=0.022). Whereas BMI did not differ across the groups (median (range): 25.5 (23.2/28.6) vs. 25.7 (23.1/28.8); p=0.486).
+
+ CONCLUSION AND SIGNIFICANCE: Among the anthropometric markers namely BMI and AG, AG is a better predictor of DM risk. Therefore AG should also be considered along with HbA1c for predicting DM risk. Copyright © Journal of the Association of Physicians of India 2011.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&AN=31793264
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rohit&issn=0004-5772&title=Journal+of+the+Association+of+Physicians+of+India&atitle=Diabetes+Risk+Diagnosis+Using+Obesity+Markers+and+Glycemic+Control+in+Indian+Population.&volume=67&issue=11&spage=22&epage=24&date=2019&doi=&pmid=31793264&sid=OVID:medline
+
+<1969>
+Unique Identifier
+ 31780038
+Title
+ Clinical and psychological responses to synbiotic supplementation in obese or overweight adults: A randomized clinical trial.
+Source
+ Complementary Therapies in Medicine. 47:102216, 2019 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hadi A; Sepandi M; Marx W; Moradi S; Parastouei K
+Authors Full Name
+ Hadi, Amir; Sepandi, Mojtaba; Marx, Wolfgang; Moradi, Sajjad; Parastouei, Karim.
+Institution
+ Hadi, Amir. Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; Department of Nutrition and food hygiene, Faculty of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran.
+ Sepandi, Mojtaba. Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; Department of Epidemiology and Biostatistics, Faculty of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran.
+ Marx, Wolfgang. Deakin University, iMPACT, School of Medicine, Geelong, Australia.
+ Moradi, Sajjad. Halal Research Center of IRI, FDA, Tehran, Iran.
+ Parastouei, Karim. Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; Department of Nutrition and food hygiene, Faculty of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Parastouei@gmail.com.
+MeSH Subject Headings
+ Adult
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Double-Blind Method
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/px [Psychology]
+ *Obesity/th [Therapy]
+ *Overweight/px [Psychology]
+ *Overweight/th [Therapy]
+ Surveys and Questionnaires
+ *Synbiotics
+ Young Adult
+Keyword Heading
+ Anxiety
+ Depression
+ Metabolic profile
+ Microbiome
+ Obesity
+ Stress
+ Synbiotics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is highly prevalent worldwide. Emerging clinical studies suggest that pre- and pro- biotic formulations may be effective interventions for the management of obesity and associated metabolic complications. The current trial was conducted to assess the effect of synbiotic supplementation on anthropometric indices, glycemic and lipid profile, blood pressure, and psychological status of adults with overweight or obesity.
+
+ METHODS: This randomized double-blind, placebo-controlled trial was conducted on 60 adults with overweight or obesity. Participants were randomly assigned into two groups to receive either synbiotics (n=30) in form of a 500mg capsule (containing Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum plus inulin) or placebo (n=30) for 8 weeks. The level of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), insulin, body weight, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), stress, anxiety, and depression were measured at the baseline and end of the study.
+
+ RESULTS: In total, 59 subjects (39 men and 20 women) completed the present study. A significant between-group decrease in body weight (P=0.03), TC (P=0.01), TG (P=0.02), LDL-C (P=0.01), stress (P<0.001), anxiety (P=0.03), and depression (P=0.03) was found in the synbiotic group compared to the placebo. However, synbiotics had no significant effect on HDL-C, SBP, DBP, FPG and fasting insulin concentrations, as well the BMI and WC (P<0.05).
+
+ CONCLUSION: The present study showed that synbiotic supplementation can confer a number of health benefits including improvements in TG, TC, LDL-C, body weight, stress, anxiety, and depression to subjects that are overweight or obesity.
+
+ TRIAL REGISTRATION: Iranian Registry of Clinical Trials IRCT20180201038585N3. Copyright © 2019 Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ctim.2019.102216
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hadi&issn=0965-2299&title=Complementary+Therapies+in+Medicine&atitle=Clinical+and+psychological+responses+to+synbiotic+supplementation+in+obese+or+overweight+adults%3A+A+randomized+clinical+trial.&volume=47&issue=&spage=102216&epage=&date=2019&doi=10.1016%2Fj.ctim.2019.102216&pmid=31780038&sid=OVID:medline
+
+<1970>
+Unique Identifier
+ 31779868
+Title
+ Atherosclerostic cardiovascular disease risk score: Are Indians underestimating the risk of cardiovascular disease?.
+Source
+ Indian Heart Journal. 71(4):364-365, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kumar A; Shariff M
+Authors Full Name
+ Kumar, Ashish; Shariff, Mariam.
+Institution
+ Kumar, Ashish. Resident, Department of Critical Care Medicine, St John's Medical College Hospital, Bangalore, India. Electronic address: ashirvadmangalore@gmail.com.
+ Shariff, Mariam. Resident, Department of Critical Care Medicine, St John's Medical College Hospital, Bangalore, India.
+MeSH Subject Headings
+ Atherosclerosis/ep [Epidemiology]
+ *Atherosclerosis/eh [Ethnology]
+ Biomarkers/an [Analysis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases/eh [Ethnology]
+ Diabetes Mellitus/ep [Epidemiology]
+ Diabetes Mellitus/eh [Ethnology]
+ Female
+ Humans
+ Hypertension/ep [Epidemiology]
+ Hypertension/eh [Ethnology]
+ India/ep [Epidemiology]
+ Male
+ Obesity/ep [Epidemiology]
+ Obesity/eh [Ethnology]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Smoking/ep [Epidemiology]
+ Smoking/eh [Ethnology]
+Keyword Heading
+ ASCVD risk score
+ ASCVD score underestimating risk
+ Indians
+Keyword Heading Owner
+ NOTNLM
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Letter.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.ihj.2019.08.002
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kumar&issn=0019-4832&title=Indian+Heart+Journal&atitle=Atherosclerostic+cardiovascular+disease+risk+score%3A+Are+Indians+underestimating+the+risk+of+cardiovascular+disease%3F.&volume=71&issue=4&spage=364&epage=365&date=2019&doi=10.1016%2Fj.ihj.2019.08.002&pmid=31779868&sid=OVID:medline
+
+<1971>
+Unique Identifier
+ 31772946
+Title
+ Association and Interaction Analysis of Lipid Accumulation Product with Impaired Fasting Glucose Risk: A Cross-Sectional Survey.
+Source
+ Journal of Diabetes Research. 2019:9014698, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Song J; Chen X; Jiang Y; Mi J; Zhang Y; Zhao Y; Wu X; Gao H
+Author NameID
+ Song, Jian; ORCID: https://orcid.org/0000-0002-8073-1836
+ Jiang, Yuhong; ORCID: https://orcid.org/0000-0002-7324-700X
+ Zhang, Yuyuan; ORCID: https://orcid.org/0000-0003-0865-9099
+ Zhao, Yingying; ORCID: https://orcid.org/0000-0003-1893-6782
+ Wu, Xuesen; ORCID: https://orcid.org/0000-0001-8438-9380
+ Gao, Huaiquan; ORCID: https://orcid.org/0000-0002-2461-0706
+Authors Full Name
+ Song, Jian; Chen, Xue; Jiang, Yuhong; Mi, Jing; Zhang, Yuyuan; Zhao, Yingying; Wu, Xuesen; Gao, Huaiquan.
+Institution
+ Song, Jian. School of Public Health, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233000 Anhui Province, China.
+ Chen, Xue. School of Public Health, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233000 Anhui Province, China.
+ Jiang, Yuhong. School of Public Health, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233000 Anhui Province, China.
+ Mi, Jing. School of Public Health, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233000 Anhui Province, China.
+ Zhang, Yuyuan. School of Public Health, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233000 Anhui Province, China.
+ Zhao, Yingying. Bengbu Health Board, 568 Nanhu Road, Bengbu, 233000 Anhui Province, China.
+ Wu, Xuesen. School of Public Health, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233000 Anhui Province, China.
+ Gao, Huaiquan. School of Public Health, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233000 Anhui Province, China.
+MeSH Subject Headings
+ Aged
+ Biomarkers/bl [Blood]
+ *Blood Glucose
+ Body Mass Index
+ China
+ Cross-Sectional Studies
+ *Fasting/bl [Blood]
+ Female
+ Glucose Intolerance/bl [Blood]
+ *Glucose Intolerance/di [Diagnosis]
+ Humans
+ *Lipid Accumulation Product/ph [Physiology]
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Prediabetic State/bl [Blood]
+ *Prediabetic State/di [Diagnosis]
+ Risk Factors
+ Surveys and Questionnaires
+Abstract
+ AIMS: Lipid accumulation product (LAP) is put forward as a powerful marker showing the accumulation of visceral fat. The present study is aimed at (i) analyzing the predictive performances of LAP in the identification of impaired fasting glucose (IFG) in Chinese population and (ii) exploring the potentially interactive effect between LAP and other factors on IFG risk.
+
+ METHODS: Analysis was conducted on the data obtained from a community-based cross-sectional survey in Chinese population, and all the participants enrolled were required to complete a face-to-face questionnaire survey and related health checks. Then, for the purpose of comparing predictive values between LAP and conventional obesity indices for IFG, relevant analysis was carried out on the receiver operating characteristic (ROC) curve. The assessment of interactive effects was conducted by employing the three indicators as follows: (1) RERI (the relative excess risk due to interaction), (2) AP (attributable proportion due to interaction), and (3) SI (synergy index).
+
+ RESULTS: A total of 1777 participants (748 males and 1029 females) were involved in the final analysis. It was finally obtained that the prevalence rate of IFG was 14.1% in total, 15.5% for males and 13.1% for females, respectively. In logistic regression analysis, individuals with LAP levels in the fourth quartile had a significant higher risk of getting IFG in comparison with that of the lowest quartile (crude OR: 4.58, 95% CI: 3.01-6.98; adjusted OR: 3.81, 95% CI: 2.33-6.23). In addition, it was indicated by the ROC curve analysis that LAP showed a better performance in discriminating IFG risk than BMI in both males (Z = 2.20, P = 0.028) and females (Z = 2.13, P = 0.033). However, LAP displayed a higher predictability in comparison with WC only in females (Z = 2.07, P = 0.038), but not in males (Z = 0.18, P = 0.860). Furthermore, LAP and family history of diabetes were able to impose significant synergistic interaction on the risk of IFG, which was indicated by all the parameters in females (RERI: 2.52, 95% CI: 0.19-4.84; AP: 0.47, 95% CI: 0.20-0.74; SI: 2.39, 95% CI: 1.17-4.87) and males (RERI: 2.18, 95% CI: 0.08-4.73; AP: 0.43, 95% CI: 0.07-0.79; SI: 2.15, 95% CI: 1.03-5.45). However, none of the indicators showed significant interaction between LAP and smoking on the risk of IFG in females (RERI: 0.92, 95% CI: -2.79-4.63; AP: 0.20, 95% CI: -0.50-0.92; SI: 1.37, 95% CI: 0.42-4.52). Meanwhile, there was also no significant interaction between LAP and smoking on the risk of IFG in males as indicated by the value of SI (2.22, 95% CI: 0.80-6.21).
+
+ CONCLUSION: It was concluded that LAP was significantly related to a higher risk of IFG in Chinese population, and its performance was superior to that of conventional obesity indices, especially in females. Apart from that, LAP with family history of diabetes may have an interactive effect that can impose a great influence on the development of IFG. Copyright © 2019 Jian Song et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f9014698
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Song&issn=2314-6753&title=Journal+of+Diabetes+Research&atitle=Association+and+Interaction+Analysis+of+Lipid+Accumulation+Product+with+Impaired+Fasting+Glucose+Risk%3A+A+Cross-Sectional+Survey.&volume=2019&issue=&spage=9014698&epage=&date=2019&doi=10.1155%2F2019%2F9014698&pmid=31772946&sid=OVID:medline
+
+<1972>
+Unique Identifier
+ 31772686
+Title
+ Serum Levels of miR-143 Predict Survival in Critically Ill Patients.
+Source
+ Disease Markers. 2019:4850472, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Roderburg C; Koch A; Benz F; Vucur M; Spehlmann M; Loosen SH; Luedde M; Rehse S; Lurje G; Trautwein C; Tacke F; Luedde T
+Author NameID
+ Roderburg, Christoph; ORCID: https://orcid.org/0000-0002-2245-6362
+ Vucur, Mihael; ORCID: https://orcid.org/0000-0003-4078-1668
+ Loosen, Sven H; ORCID: https://orcid.org/0000-0003-3447-1161
+ Tacke, Frank; ORCID: https://orcid.org/0000-0001-6206-0226
+ Luedde, Tom; ORCID: https://orcid.org/0000-0002-6288-8821
+Authors Full Name
+ Roderburg, Christoph; Koch, Alexander; Benz, Fabian; Vucur, Mihael; Spehlmann, Martina; Loosen, Sven H; Luedde, Mark; Rehse, Sebastian; Lurje, Georg; Trautwein, Christian; Tacke, Frank; Luedde, Tom.
+Institution
+ Roderburg, Christoph. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Roderburg, Christoph. Department of Gastroenterology/Hepatology, Charite University Medical Center Berlin, Campus Virchow Klinikum and Charite Mitte, Augustenburger Platz 1, 13353 Berlin, Germany.
+ Koch, Alexander. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Benz, Fabian. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Benz, Fabian. Department of Gastroenterology/Hepatology, Charite University Medical Center Berlin, Campus Virchow Klinikum and Charite Mitte, Augustenburger Platz 1, 13353 Berlin, Germany.
+ Vucur, Mihael. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Spehlmann, Martina. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Loosen, Sven H. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Luedde, Mark. Department of Internal Medicine III, University of Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany.
+ Rehse, Sebastian. Department of Internal Medicine, Hospital of Preetz, Am Krankenhaus 5, 24211 Preetz, Germany.
+ Lurje, Georg. Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Trautwein, Christian. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Tacke, Frank. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Tacke, Frank. Department of Gastroenterology/Hepatology, Charite University Medical Center Berlin, Campus Virchow Klinikum and Charite Mitte, Augustenburger Platz 1, 13353 Berlin, Germany.
+ Luedde, Tom. Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+ Luedde, Tom. Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Area Under Curve
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ Comorbidity
+ *Critical Illness/mo [Mortality]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Female
+ Humans
+ Intensive Care Units
+ Kaplan-Meier Estimate
+ Male
+ *MicroRNAs/bl [Blood]
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Sepsis/bl [Blood]
+ Sepsis/ge [Genetics]
+ Young Adult
+Abstract
+ BACKGROUND AND AIMS: Recent data suggested a potential role of miR-143 as a biomarker for systemic inflammation and infection. However, its role in critical illness and sepsis is only poorly understood.
+
+ METHODS: We determined circulating levels of miR-143 in 218 critically ill patients, of which 135 fulfilled sepsis criteria, and compared them to 76 healthy controls. Results were correlated with clinical records.
+
+ RESULTS: In the total cohort of critically ill patients from a medical intensive care unit (ICU), miR-143 serum levels tended to be lower compared to healthy control samples, but this difference did not reach statistical significance. In ICU patients, serum levels of miR-143 were independent of disease etiology, including the presence of sepsis, or severity of disease. Importantly, low miR-143 serum levels were associated with an unfavorable short- and long-term prognosis in ICU patients. Our study identified different optimal cut-off values at which low miR-143 serum levels predicted mortality with a high diagnostic accuracy. In line with this, concentrations of circulating miR-143 correlated with markers of organ failure such as creatinine, bilirubin, or lactate in our cohort of critically ill patients.
+
+ CONCLUSION: Low miR-143 serum levels are indicative for an unfavorable short- and long-term prognosis in critically ill patients admitted to a medical ICU. Our data suggest a previously unrecognized role for miR-143 measurements as a novel prognostic marker in critically ill patients. Copyright © 2019 Christoph Roderburg et al.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MIRN143 microRNA, human). 0 (MicroRNAs).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f4850472
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Roderburg&issn=0278-0240&title=Disease+Markers&atitle=Serum+Levels+of+miR-143+Predict+Survival+in+Critically+Ill+Patients.&volume=2019&issue=&spage=4850472&epage=&date=2019&doi=10.1155%2F2019%2F4850472&pmid=31772686&sid=OVID:medline
+
+<1973>
+Unique Identifier
+ 31771921
+Title
+ Impact on cardiometabolic risk of a weight loss intervention with higher protein from lean red meat: Combined results of 2 randomized controlled trials in obese middle-aged and older adults.
+Source
+ Journal of Clinical Lipidology. 13(6):920-931, 2019 Nov - Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Porter Starr KN; Connelly MA; Orenduff MC; McDonald SR; Sloane R; Huffman KM; Kraus WE; Bales CW
+Authors Full Name
+ Porter Starr, Kathryn N; Connelly, Margery A; Orenduff, Melissa C; McDonald, Shelley R; Sloane, Richard; Huffman, Kim M; Kraus, William E; Bales, Connie W.
+Institution
+ Porter Starr, Kathryn N. Center for the Study of Aging, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Duke University School of Medicine, Durham, NC, USA; Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA. Electronic address: kathryn.starr@dm.duke.edu.
+ Connelly, Margery A. Laboratory Corporation of America Holdings (LabCorp), Morrisville, NC, USA.
+ Orenduff, Melissa C. Center for the Study of Aging, Duke University School of Medicine, Durham, NC, USA.
+ McDonald, Shelley R. Center for the Study of Aging, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Duke University School of Medicine, Durham, NC, USA; Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA.
+ Sloane, Richard. Center for the Study of Aging, Duke University School of Medicine, Durham, NC, USA; Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA.
+ Huffman, Kim M. Department of Medicine and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
+ Kraus, William E. Department of Medicine and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
+ Bales, Connie W. Center for the Study of Aging, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Duke University School of Medicine, Durham, NC, USA; Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Body Weight/ph [Physiology]
+ Cardiovascular Diseases/bl [Blood]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ *Diet, Carbohydrate-Restricted
+ Female
+ Humans
+ Insulin Resistance/ph [Physiology]
+ Lipoproteins/bl [Blood]
+ Magnetic Resonance Spectroscopy
+ Male
+ Middle Aged
+ Obesity
+ Red Meat
+ Weight Loss
+Keyword Heading
+ Cardiovascular disease risk
+ Insulin resistance
+ Middle-aged adults
+ Obesity
+ Older adults
+ Protein
+ Red meat
+ Weight loss intervention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The recognized benefits of a higher protein diet on muscle mass and strength in older adults are tempered by concerns of the potentially negative cardiometabolic impact of dietary sources of animal protein.
+
+ OBJECTIVE: The aim of this study was to explore the cardiometabolic impact of 2 weight reduction diets: a higher protein diet, providing balanced portions of lean beef and pork throughout the day, vs. a diet following the Recommended Daily Allowance level of protein in obese middle-aged and older adults.
+
+ METHODS: Data from Measuring Eating, Activity and Strength: Understanding the Response-Using Protein and Protein Optimization in Women Enables Results-Using Protein were combined for the present analysis. Subjects were randomly assigned to a 6-month weight loss diet (500 kcal deficit) and prescribed a Recommended Daily Allowance level of protein (0.8 g protein/kg BW), control group, or a higher level of protein (1.2 g protein/kg BW), protein group. For the protein group, lean, high-quality protein was evenly distributed between meals or balanced throughout the day (30 g protein/meal). The following cardiometabolic markers were quantified by nuclear magnetic resonance spectroscopy: lipids, lipoproteins, GlycA, trimethylamine-N-oxide, betaine, branched-chain amino acids, and lipoprotein insulin resistance index scores.
+
+ RESULTS: In both groups (control [n = 27] and protein [n = 53]), there were significant (P <= .05) changes from baseline in weight loss (-6.2% and -7.2%), distance walked (+53.1 and +75.0 meters), and fasting plasma glucose (-7.5 and -6.2 mg/dL), respectively. At endpoint, protein group had significantly (P <= .05) lower triglycerides (-17.3 mg/dL), large very-low-density lipoprotein particle concentration (VLDL-P; -1.2 nmol/L), total low-density lipoprotein particle concentration (LDL-P; -67.8 nmol/L), small LDL-P (-59.4 nmol/L) and lipoprotein insulin resistance index (-5.9), whereas control group had significantly (P <= .05) lower GlycA (-13.1 mumol/L), total VLDL-P (-7.9 nmol/L), and small VLDL-P (-7.0 nmol/L). Differences between groups were observed for small VLDL-P (P = .02) and protein intake (P < .0001).
+
+ CONCLUSIONS: These findings suggest that a hypocaloric diet with either traditional (0.8 g/kg BW/d) or higher protein (1.2 g/kg BW/d; predominantly from lean red meat) content improves risk markers of cardiovascular disease and type II diabetes in obese middle-aged and older adults. Both diets were also associated with improved physical function, and neither had an adverse impact on cardiometabolic outcomes. Copyright Published by Elsevier Inc.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipoproteins).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.jacl.2019.09.012
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Porter+Starr&issn=1933-2874&title=Journal+of+Clinical+Lipidology&atitle=Impact+on+cardiometabolic+risk+of+a+weight+loss+intervention+with+higher+protein+from+lean+red+meat%3A+Combined+results+of+2+randomized+controlled+trials+in+obese+middle-aged+and+older+adults.&volume=13&issue=6&spage=920&epage=931&date=2019&doi=10.1016%2Fj.jacl.2019.09.012&pmid=31771921&sid=OVID:medline
+
+<1974>
+Unique Identifier
+ 31771561
+Title
+ The role of the adipocytokines vaspin and visfatin in vascular endothelial function and insulin resistance in obese children.
+Source
+ BMC Endocrine Disorders. 19(1):127, 2019 Nov 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yin C; Hu W; Wang M; Xiao Y
+Authors Full Name
+ Yin, Chunyan; Hu, Wei; Wang, Ming; Xiao, Yanfeng.
+Institution
+ Yin, Chunyan. Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 of West 5th Road, Xi'an, ShanXi, 710049, People's Republic of China.
+ Hu, Wei. Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 of West 5th Road, Xi'an, ShanXi, 710049, People's Republic of China.
+ Wang, Ming. Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 of West 5th Road, Xi'an, ShanXi, 710049, People's Republic of China.
+ Xiao, Yanfeng. Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 of West 5th Road, Xi'an, ShanXi, 710049, People's Republic of China. xiaoyanfenggroup@sina.com.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ Child
+ *Cytokines/bl [Blood]
+ Endothelium, Vascular/me [Metabolism]
+ *Endothelium, Vascular/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation/pa [Pathology]
+ *Insulin Resistance
+ Male
+ *Nicotinamide Phosphoribosyltransferase/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Prognosis
+ *Serpins/bl [Blood]
+ *Thinness/bl [Blood]
+ Thinness/ep [Epidemiology]
+ Thinness/pp [Physiopathology]
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Keyword Heading
+ Endothelial dysfunction
+ Obese children
+ Vascular inflammation
+ Vaspin
+ Visfatin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: We measured the concentrations of the adipocytokines vaspin and visfatin in obese Chinese children. Furthermore, we studied the correlation of these adipocytokines with early-onset metabolic and vascular sequelae among these children.
+
+ METHODS: A total of 244 children (160 obese and 84 lean) were included in this study. Vaspin and visfatin were detected using enzyme-linked immunosorbent assays. We also assayed other metabolic and cardiovascular parameters. The associations of serum vaspin and visfatin concentrations with metabolic and cardiovascular parameters were determined.
+
+ RESULTS: We found a significant elevation in the concentrations of vaspin and visfatin in obese children compared to the concentrations in lean children. Additionally, we found a significant positive correlation between visfatin and vaspin levels, as well as inflammatory cell infiltration and markers of endothelial activation, but these factors did not affect insulin resistance in obese children. Multiple regression analyses confirmed that vaspin is the strongest predictor of higher tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), angiotensin-2 (Ang-2), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin levels. We also found a significant association between visfatin and Ang-2, IL-6, VCAM-1, and E-selectin levels.
+
+ CONCLUSION: The adipocytokines vaspin and visfatin are significantly interrelated, and both adipocytokines play a role in vascular endothelial function and inflammation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (SERPINA12 protein, human). 0 (Serpins). 0 (TNF protein, human). 0 (Tumor Necrosis Factor-alpha). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase). EC 2-4-2-12 (nicotinamide phosphoribosyltransferase, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0452-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yin&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=The+role+of+the+adipocytokines+vaspin+and+visfatin+in+vascular+endothelial+function+and+insulin+resistance+in+obese+children.&volume=19&issue=1&spage=127&epage=&date=2019&doi=10.1186%2Fs12902-019-0452-6&pmid=31771561&sid=OVID:medline
+
+<1975>
+Unique Identifier
+ 31770380
+Title
+ The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women.
+Source
+ PLoS ONE [Electronic Resource]. 14(11):e0224942, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fu CP; Ali H; Rachakonda VP; Oczypok EA; DeLany JP; Kershaw EE
+Author NameID
+ Fu, Chia-Po; ORCID: https://orcid.org/0000-0001-5210-9444
+Authors Full Name
+ Fu, Chia-Po; Ali, Hira; Rachakonda, Vikrant P; Oczypok, Elizabeth A; DeLany, James P; Kershaw, Erin E.
+Institution
+ Fu, Chia-Po. Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
+ Fu, Chia-Po. Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
+ Fu, Chia-Po. Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan.
+ Ali, Hira. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
+ Rachakonda, Vikrant P. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
+ Oczypok, Elizabeth A. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
+ DeLany, James P. Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida, United States of America.
+ Kershaw, Erin E. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ *Biomarkers/me [Metabolism]
+ Female
+ Humans
+ Intra-Abdominal Fat/pa [Pathology]
+ Lipids/ch [Chemistry]
+ Middle Aged
+ *Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ North America
+ *Obesity/co [Complications]
+ ROC Curve
+Abstract
+ INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the western world and is highly associated with multiple cardiometabolic complications. The Zhejiang University (ZJU) index was first developed to predict NAFLD in Chinese populations, where it was shown to have better predictive value than other currently used indices. The aims of the present study were to 1) determine the diagnostic accuracy of ZJU index in identifying NAFLD in a well-phenotyped cohort of obese middle-aged American women and 2) compare its performance with other non-invasive indices for NAFLD identification.
+
+ METHODS: To achieve this goal, we performed a retrospective analysis of a prospectively-collected cohort of participants enrolled in a weight loss trial for severe obesity (RENEW, clinicaltrials.gov identifier: NCT00712127). One hundred and seven women between the age of 30 and 55 with obesity class II (BMI 35-39.9 kg/m2) or class III (BMI >= 40 kg/m2) were recruited for analyses. Hepatic steatosis was measured using liver/spleen attenuation ratio (L/S ratio) from unenhanced abdominal computed tomography. Beside ZJU index, hepatic steatosis index (HSI), lipid accumulation production index (LAPI), and visceral adiposity index (VAI) were also determined and to compare their performance in predicting NAFLD.
+
+ RESULTS: Of 107 obese women in the study, 40 (37.4%) met imaging criteria for NAFLD using cut-off value of L/S ratio < 1.1. The ZJU index was positively correlated with HIS, LAPI, but not VAI. The area under the curve was highest for the ZJU index (AUC = 0.742, 95% CI:0.647-0.837), followed by HSI (AUC = 0.728, 95% CI:0.631-0.825), LAPI (AUC = 0.682, CI:0.583-0.781), and VAI (AUC = 0.621, 95% CI:0.518-0.725), respectively, using the Youden method.
+
+ CONCLUSION: The ZJU index is a powerful surrogate marker for NAFLD in severely obese western females and its predictive value was better than that of other commonly used indices for predicting NAFLD. Our study is the first to suggest that the ZJU index could be a promising model for use in western as well as Chinese populations.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0224942
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fu&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=The+ZJU+index+is+a+powerful+surrogate+marker+for+NAFLD+in+severely+obese+North+American+women.&volume=14&issue=11&spage=e0224942&epage=&date=2019&doi=10.1371%2Fjournal.pone.0224942&pmid=31770380&sid=OVID:medline
+
+<1976>
+Unique Identifier
+ 31752704
+Title
+ Elevated serum triglyceride and low-density lipoprotein cholesterol promotes the formation of colorectal polyps.
+Source
+ BMC Gastroenterology. 19(1):195, 2019 Nov 21.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xie C; Wen P; Su J; Li Q; Ren Y; Liu Y; Shen R; Ren J
+Authors Full Name
+ Xie, Chenxi; Wen, Pingwu; Su, Jingling; Li, Qin; Ren, Yandan; Liu, Yueyu; Shen, Renze; Ren, Jianlin.
+Institution
+ Xie, Chenxi. Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian Province, 361000, People's Republic of China.
+ Wen, Pingwu. Department of Gastroenterology, Meizhou Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong Province, 514000, People's Republic of China.
+ Su, Jingling. Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian Province, 361000, People's Republic of China.
+ Li, Qin. Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong Province, 510080, People's Republic of China.
+ Ren, Yandan. Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian Province, 361000, People's Republic of China.
+ Liu, Yueyu. Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian Province, 361000, People's Republic of China.
+ Shen, Renze. Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian Province, 361000, People's Republic of China. fjzzxcx17@163.com.
+ Shen, Renze. Renze Shen, Department of Stomatology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian Province, 361000, People's Republic of China. fjzzxcx17@163.com.
+ Ren, Jianlin. Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian Province, 361000, People's Republic of China. fjzzxcx17@163.com.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Biomarkers/bl [Blood]
+ *Cholesterol, LDL/bl [Blood]
+ *Colonic Polyps/bl [Blood]
+ Colonic Polyps/di [Diagnosis]
+ Colonoscopy
+ Humans
+ Hyperlipidemias/co [Complications]
+ *Intestinal Polyps/bl [Blood]
+ Intestinal Polyps/di [Diagnosis]
+ Middle Aged
+ Obesity/co [Complications]
+ Prospective Studies
+ *Rectal Diseases/bl [Blood]
+ Rectal Diseases/di [Diagnosis]
+ Risk Factors
+ *Triglycerides/bl [Blood]
+Keyword Heading
+ advanced adenoma
+ colorectal polyp
+ low-density lipoprotein cholesterol
+ triglyceride
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hyperlipidaemia may be a potential risk factor for the occurrence of intestinal polyps. This study aimed to evaluate correlation between lipidaemia and the formation of colorectal polyps.
+
+ METHODS: One hundred and fourteen patients with colorectal polyps and forty-eight healthy controls were included in this study. Colonoscopies were performed for all patients and controls within 1 week before blood samples were taken. The concentrations of serum lipids and lipoproteins were measured simultaneously using an automatic biochemical analyser. The colorectal lesions were classified based on pathological characteristics, and four types were identified in the study: hyperplastic polyp (HP), tubular adenoma (TA), tubulovillous adenoma (TVA) and adenoma with high-grade dysplasia (A-HGD). Advanced adenoma was classified according to the number, size and histological type of polyps.
+
+ RESULTS: The value of low-density lipoprotein cholesterol (LDL-C) was significantly higher in the group with advanced adenoma than in the controls (p < 0.05). Moreover, the LDL-C values in the HP and TA groups were higher when compared to that of controls (p < 0.05). Obesity, age, and increased TG and LDL-C were independent risk factors for the formation of colorectal polyps. The cut-off values of triglyceride (TG) and LDL-C to distinguish polyp patients from healthy controls were 0.96 mmol/L (AUC = 0.604, p = 0.036) and 3.05 mmol/L (AUC = 0.654, p = 0.002). The combined use of increased LDL-C and TG levels to distinguish polyp patients was effective, with a sensitivity of 50.0% and a specificity of 89.6% (AUC = 0.733, p < 0.01).
+
+ CONCLUSIONS: Colorectal polyps are more often found in obese and older patients. Increased LDL-C and TG were correlated with the occurrence of polyps. Combination of the two serum indicators was useful to assess risk of colorectal lesions, maybe more effective in screening hyperplastic polyp, tubular adenoma and advanced adenoma.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12876-019-1115-9
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xie&issn=1471-230X&title=BMC+Gastroenterology&atitle=Elevated+serum+triglyceride+and+low-density+lipoprotein+cholesterol+promotes+the+formation+of+colorectal+polyps.&volume=19&issue=1&spage=195&epage=&date=2019&doi=10.1186%2Fs12876-019-1115-9&pmid=31752704&sid=OVID:medline
+
+<1977>
+Unique Identifier
+ 31723209
+Title
+ Sphingolipid serum profiling in vitamin D deficient and dyslipidemic obese dimorphic adults.
+Source
+ Scientific Reports. 9(1):16664, 2019 11 13.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Daghri NM; Torretta E; Barbacini P; Asare H; Ricci C; Capitanio D; Guerini FR; Sabico SB; Alokail MS; Clerici M; Gelfi C
+Author NameID
+ Ricci, Cristian; ORCID: http://orcid.org/0000-0003-4113-8682
+ Gelfi, Cecilia; ORCID: http://orcid.org/0000-0002-2996-6912
+Authors Full Name
+ Al-Daghri, Nasser M; Torretta, Enrica; Barbacini, Pietro; Asare, Hannah; Ricci, Cristian; Capitanio, Daniele; Guerini, Franca Rosa; Sabico, Shaun B; Alokail, Majed S; Clerici, Mario; Gelfi, Cecilia.
+Institution
+ Al-Daghri, Nasser M. Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
+ Torretta, Enrica. Department of Biomedical Sciences for Health, University of Milan, Segrate-Milano, Italy.
+ Barbacini, Pietro. Department of Biomedical Sciences for Health, University of Milan, Segrate-Milano, Italy.
+ Asare, Hannah. Centre of Excellence for Nutrition (CEN), Potchefstroom, 2531, South Africa.
+ Ricci, Cristian. Centre of Excellence for Nutrition (CEN), Potchefstroom, 2531, South Africa.
+ Capitanio, Daniele. Department of Biomedical Sciences for Health, University of Milan, Segrate-Milano, Italy.
+ Capitanio, Daniele. IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.
+ Guerini, Franca Rosa. IRCCS Fondazione Don Carlo Gnocchi, Milano, Italy.
+ Sabico, Shaun B. Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
+ Alokail, Majed S. Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
+ Clerici, Mario. IRCCS Fondazione Don Carlo Gnocchi, Milano, Italy.
+ Clerici, Mario. Department of Physiopathology and Transplants, University of Milano, Milano, Italy.
+ Gelfi, Cecilia. Department of Biomedical Sciences for Health, University of Milan, Segrate-Milano, Italy. cecilia.gelfi@unimi.it.
+ Gelfi, Cecilia. IRCCS Istituto Ortopedico Galeazzi, Milano, Italy. cecilia.gelfi@unimi.it.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ *Dyslipidemias/ep [Epidemiology]
+ Female
+ Humans
+ Italy/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Prevalence
+ Prognosis
+ *Sphingolipids/bl [Blood]
+ Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/di [Diagnosis]
+ *Vitamin D Deficiency/ep [Epidemiology]
+Abstract
+ Recent studies on Saudi Arabians indicate a prevalence of dyslipidemia and vitamin D deficiency (25(OH)D) in both normal weight and obese subjects. In the present study the sphingolipid pattern was investigated in 23 normolipidemic normal weight (NW), 46 vitamin D deficient dyslipidemic normal weight (-vitDNW) and 60 vitamin D deficient dyslipidemic obese (-vitDO) men and women by HPTLC-primuline profiling and LC-MS analyses. Results indicate higher levels of total ceramide (Cer) and dihydroceramide (dhCers C18-22) and lower levels of total sphingomyelins (SMs) and dihydrosphingomyelin (dhSM) not only in -vitDO subjects compared to NW, but also in -vitDNW individuals. A dependency on body mass index (BMI) was observed analyzing specific Cer acyl chains levels. Lower levels of C20 and 24 were observed in men and C24.2 in women, respectively. Furthermore, LC-MS analyses display dimorphic changes in NW, -vitDNW and -vitDO subjects. In conclusion, LC-MS data identify the independency of the axis high Cers, dhCers and SMs from obesity per se. Furthermore, it indicates that long chains Cers levels are specific target of weight gain and that circulating Cer and SM levels are linked to sexual dimorphism status and can contribute to predict obese related co-morbidities in men and women.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Sphingolipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-53122-4
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Daghri&issn=2045-2322&title=Scientific+Reports&atitle=Sphingolipid+serum+profiling+in+vitamin+D+deficient+and+dyslipidemic+obese+dimorphic+adults.&volume=9&issue=1&spage=16664&epage=&date=2019&doi=10.1038%2Fs41598-019-53122-4&pmid=31723209&sid=OVID:medline
+
+<1978>
+Unique Identifier
+ 31718015
+Title
+ Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation.
+Source
+ Cells. 8(11), 2019 11 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sindhu S; Thomas R; Kochumon S; Wilson A; Abu-Farha M; Bennakhi A; Al-Mulla F; Ahmad R
+Author NameID
+ Sindhu, Sardar; ORCID: https://orcid.org/0000-0001-9936-1575
+ Abu-Farha, Mohamed; ORCID: https://orcid.org/0000-0001-8357-1252
+ Al-Mulla, Fahd; ORCID: https://orcid.org/0000-0001-5409-3829
+ Ahmad, Rasheed; ORCID: https://orcid.org/0000-0001-5746-0743
+Authors Full Name
+ Sindhu, Sardar; Thomas, Reeby; Kochumon, Shihab; Wilson, Ajit; Abu-Farha, Mohamed; Bennakhi, Abdullah; Al-Mulla, Fahd; Ahmad, Rasheed.
+Institution
+ Sindhu, Sardar. Animal & Imaging Core Facility, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Thomas, Reeby. Department of Microbiology & Immunology, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Kochumon, Shihab. Department of Microbiology & Immunology, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Wilson, Ajit. Department of Microbiology & Immunology, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Abu-Farha, Mohamed. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Bennakhi, Abdullah. Medical Division, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Al-Mulla, Fahd. Department of Genetics & Bioinformatics, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+ Ahmad, Rasheed. Department of Microbiology & Immunology, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, Dasman 15462, Kuwait.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Adipose Tissue/pa [Pathology]
+ Adult
+ Aged
+ Biomarkers
+ Body Weights and Measures
+ Cytokines/me [Metabolism]
+ Energy Metabolism
+ Female
+ *Gene Expression Regulation
+ Humans
+ Immunomodulation
+ Inflammation/co [Complications]
+ Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ Inflammation Mediators/me [Metabolism]
+ *Interferon Regulatory Factors/ge [Genetics]
+ Interferon Regulatory Factors/me [Metabolism]
+ Male
+ Middle Aged
+ Models, Biological
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Phenotype
+ Young Adult
+Keyword Heading
+ adipose tissue
+ interferon regulatory factor-5
+ metabolic inflammation
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Interferon regulatory factor (IRF)-5 is known to be involved in M1 macrophage polarization, however, changes in the adipose expression of IRF5 in obesity and their relationship with the local expression of proinflammatory cytokines/chemokines are unknown. Therefore, IRF5 gene expression was determined in the subcutaneous adipose tissue samples from 53 non-diabetic individuals (6 lean, 18 overweight, and 29 obese), using real-time RT-PCR. IRF5 protein expression was also assessed using immunohistochemistry and/or confocal microscopy. Adipose gene expression of signature immune metabolic markers was also determined and compared with adipose IRF5 gene expression. Systemic levels of C-reactive protein and adiponectin were measured by ELISA. The data show that adipose IRF5 gene (P = 0.008) and protein (P = 0.004) expression was upregulated in obese compared with lean individuals. IRF5 expression changes correlated positively with body mass index (BMI; r = 0.37/P = 0.008) and body fat percentage (r = 0.51/P = 0.0004). In obese, IRF5 changes associated positively with HbA1c (r = 0.41/P = 0.02). A good agreement was found between gene and protein expression of IRF5 in obese subjects (r = 0.65/P = 0.001). IRF5 gene expression associated positively with adipose inflammatory signatures including local expression of TNF-alpha, IL-6, CXCL8, CCL-2/5, IL-1beta, IL-18, CXCL-9/10, CCL7, CCR-1/2/5, TLR-2/7/8/9, IRF3, MyD88, IRAK-1, and inflammatory macrophage markers (P < 0.05). Interestingly, IRF5 gene expression correlated positively with CRP (r = 0.37, P = 0.03) and negatively with adiponectin levels (r = -0.43, P = 0.009). In conclusion, elevated adipose IRF5 expression in obesity concurs with the typical inflammatory signatures, locally and systemically. Hence, the IRF5 upregulation may represent a novel adipose tissue marker for metabolic inflammation.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines). 0 (IRF5 protein, human). 0 (Inflammation Mediators). 0 (Interferon Regulatory Factors).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fcells8111418
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sindhu&issn=2073-4409&title=Cells&atitle=Increased+Adipose+Tissue+Expression+of+Interferon+Regulatory+Factor+%28IRF%29-5+in+Obesity%3A+Association+with+Metabolic+Inflammation.&volume=8&issue=11&spage=&epage=&date=2019&doi=10.3390%2Fcells8111418&pmid=31718015&sid=OVID:medline
+
+<1979>
+Unique Identifier
+ 31714931
+Title
+ Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis.
+Source
+ PLoS ONE [Electronic Resource]. 14(11):e0225185, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Borshchev YY; Minasian SM; Burovenko IY; Borshchev VY; Protsak ES; Semenova NY; Borshcheva OV; Galagudza MM
+Author NameID
+ Protsak, Egor S; ORCID: https://orcid.org/0000-0002-9217-9890
+ Galagudza, Michael M; ORCID: https://orcid.org/0000-0001-5129-9944
+Authors Full Name
+ Borshchev, Yury Yu; Minasian, Sarkis M; Burovenko, Inessa Yu; Borshchev, Victor Yu; Protsak, Egor S; Semenova, Natalia Yu; Borshcheva, Olga V; Galagudza, Michael M.
+Institution
+ Borshchev, Yury Yu. Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation.
+ Borshchev, Yury Yu. Scientific Research Center "Probiocode SP", Moscow, Russian Federation.
+ Minasian, Sarkis M. Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation.
+ Minasian, Sarkis M. Department of Pathophysiology, Saint Petersburg Pavlov State Medical University, Saint Petersburg, Russian Federation.
+ Burovenko, Inessa Yu. Scientific Research Center "Probiocode SP", Moscow, Russian Federation.
+ Burovenko, Inessa Yu. Department of Physiology and Sanocreatology, Shevchenko Transnistria State University, Tiraspol, Republic of Moldova.
+ Borshchev, Victor Yu. Department of Microelectronics and Biomedical Engineering, Technical University of Moldova, Chisinau, Republic of Moldova.
+ Protsak, Egor S. Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation.
+ Protsak, Egor S. Department of Pathophysiology, Saint Petersburg Pavlov State Medical University, Saint Petersburg, Russian Federation.
+ Semenova, Natalia Yu. Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation.
+ Borshcheva, Olga V. Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation.
+ Borshcheva, Olga V. Scientific Research Center "Probiocode SP", Moscow, Russian Federation.
+ Galagudza, Michael M. Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation.
+ Galagudza, Michael M. Department of Pathophysiology, Saint Petersburg Pavlov State Medical University, Saint Petersburg, Russian Federation.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Body Weight
+ *Colitis/co [Complications]
+ Disease Models, Animal
+ Fatty Acids, Volatile/me [Metabolism]
+ Gastrointestinal Microbiome
+ Heart Function Tests
+ Male
+ *Myocardial Infarction/et [Etiology]
+ *Myocardial Infarction/pa [Pathology]
+ *Obesity/co [Complications]
+ Rats
+ *Tetracycline/pd [Pharmacology]
+Abstract
+ BACKGROUND: Recent evidence suggests that antibiotic-induced changes in the composition of intestinal microflora, as well as the systemic immunoendocrine effects that result from them, can modulate myocardial tolerance to ischemia-reperfusion injury. The aim of this study was to investigate the effects of tetracycline (TTC) on myocardial infarct size in the isolated hearts obtained from obese rats with chemically-induced colitis (CIC). The association between TTC-induced changes in infarct size and intestinal microbiome composition as well as plasma levels of cytokines and short-chain fatty acids (SCFAs) was also studied.
+
+ METHODS: Obesity was induced in Wistar rats by feeding them a high-fat, high-carbohydrate diet for five weeks. A single rectal administration of 3% acetic acid (2 mL) to the rats resulted in CIC. Healthy rats as well as obese rats with CIC received TTC (15 mg daily for 3 days) via gavage. The rats were euthanized, after which isolated heart perfusion with simulated global ischemia and reperfusion was performed. Infarct size was determined histochemically. Lipopolysaccharide (LPS) and cytokine levels in plasma were measured by enzyme-linked immunosorbent assay, whereas SCFA levels in plasma were measured by gas chromatography/mass spectrometry. The intestinal microbiome was analyzed using reverse transcription polymerase chain reaction.
+
+ RESULTS: The treatment with TTC resulted in significant infarct size limitation (50 +/- 7 vs. 62 +/- 4% for the control mice, p < 0.05) in the hearts from intact animals. However, infarct size was not different between the control rats and the obese rats with CIC. Furthermore, infarct size was significantly larger in TTC-treated obese rats with CIC than it was in the control animals (77 +/- 5%, p < 0.05). The concentrations of proinflammatory cytokines and LPS in serum were elevated in the obese rats with CIC. Compared to the control rats, the rats with both obesity and CIC had lower counts of Lactobacillus and Bifidobacterium spp. but higher counts of Escherichia coli. The effects of TTC on infarct size were not associated with specific changes in SCFA levels.
+
+ CONCLUSIONS: TTC reduced infarct size in the healthy rats. However, this effect was reversed in the obese animals with CIC. Additionally, it was associated with specific changes in gut microbiota and significantly elevated levels of cytokines and LPS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acids, Volatile). F8VB5M810T (Tetracycline).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0225185
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Borshchev&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Effects+of+tetracycline+on+myocardial+infarct+size+in+obese+rats+with+chemically-induced+colitis.&volume=14&issue=11&spage=e0225185&epage=&date=2019&doi=10.1371%2Fjournal.pone.0225185&pmid=31714931&sid=OVID:medline
+
+<1980>
+Unique Identifier
+ 31712385
+Title
+ Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis.
+Source
+ Journal of Immunology. 203(12):3427-3435, 2019 12 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Park C; Cheung KP; Limon N; Costanzo A; Barba C; Miranda N; Gargas S; Johnson AMF; Olefsky JM; Jameson JM
+Author NameID
+ Park, Christa; ORCID: https://orcid.org/0000-0001-5003-2199
+ Limon, Natalie; ORCID: https://orcid.org/0000-0002-8139-873X
+ Costanzo, Anne; ORCID: https://orcid.org/0000-0003-1934-5319
+ Miranda, Nadia; ORCID: https://orcid.org/0000-0002-7003-8368
+ Olefsky, Jerrold M; ORCID: https://orcid.org/0000-0003-0392-1705
+ Jameson, Julie M; ORCID: https://orcid.org/0000-0003-0727-4066
+Authors Full Name
+ Park, Christa; Cheung, Kitty P; Limon, Natalie; Costanzo, Anne; Barba, Cindy; Miranda, Nadia; Gargas, Shannon; Johnson, Andrew M F; Olefsky, Jerrold M; Jameson, Julie M.
+Institution
+ Park, Christa. Department of Biology, California State University San Marcos, San Marcos, CA 92069.
+ Cheung, Kitty P. Department of Biology, California State University San Marcos, San Marcos, CA 92069.
+ Cheung, Kitty P. Department of Biology, Division of Molecular Biology, University of California San Diego, San Diego, CA 92093; and.
+ Limon, Natalie. Department of Biology, California State University San Marcos, San Marcos, CA 92069.
+ Costanzo, Anne. Department of Biology, California State University San Marcos, San Marcos, CA 92069.
+ Barba, Cindy. Department of Biology, California State University San Marcos, San Marcos, CA 92069.
+ Miranda, Nadia. Department of Biology, California State University San Marcos, San Marcos, CA 92069.
+ Gargas, Shannon. Department of Biology, California State University San Marcos, San Marcos, CA 92069.
+ Johnson, Andrew M F. Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, San Diego, CA 92093.
+ Olefsky, Jerrold M. Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, San Diego, CA 92093.
+ Jameson, Julie M. Department of Biology, California State University San Marcos, San Marcos, CA 92069; jjameson@csusm.edu.
+MeSH Subject Headings
+ Age Factors
+ Animals
+ Antigens, CD/ge [Genetics]
+ Antigens, CD/me [Metabolism]
+ Biomarkers
+ *Colitis/et [Etiology]
+ *Colitis/me [Metabolism]
+ Colitis/pa [Pathology]
+ Dextran Sulfate/ae [Adverse Effects]
+ Diet, High-Fat
+ Disease Models, Animal
+ Fluorescent Antibody Technique
+ Gene Expression Regulation
+ Immunohistochemistry
+ *Immunomodulation
+ Integrin alpha Chains/ge [Genetics]
+ Integrin alpha Chains/me [Metabolism]
+ *Intraepithelial Lymphocytes/im [Immunology]
+ *Intraepithelial Lymphocytes/me [Metabolism]
+ Male
+ Mice
+ Obesity/co [Complications]
+ *Obesity/im [Immunology]
+ *Obesity/me [Metabolism]
+ Receptors, CCR/ge [Genetics]
+ Receptors, CCR/me [Metabolism]
+ Receptors, Tumor Necrosis Factor/me [Metabolism]
+ Severity of Illness Index
+ Signal Transduction
+ Spleen/im [Immunology]
+ Spleen/me [Metabolism]
+ Thymus Gland/im [Immunology]
+ Thymus Gland/me [Metabolism]
+Abstract
+ Obesity impacts over 30% of the United States population, resulting in a wide array of complications. Included among these is the deterioration of the intestinal barrier, which has been implicated in type 2 diabetes and susceptibility to bacterial transepithelial migration. The intestinal epithelium is maintained by alphabeta and gammadelta intraepithelial T lymphocytes, which migrate along the epithelia, support epithelial homeostasis, and protect from infection. In this study, we investigate how obesity impacts intraepithelial lymphocyte (IEL) persistence and function in intestinal homeostasis and repair. Mice were fed a high-fat diet to induce obesity and to study immunomodulation in the intestine. There is a striking reduction in alphabeta and gammadelta IEL persistence as obesity progresses with a different mechanism in alphabeta versus gammadelta IEL populations. CD4+ and CD4+CD8+ alphabeta intraepithelial T lymphocytes exhibit reduced homeostatic proliferation in obesity, whereas both alphabeta and gammadelta IELs downregulate CD103 and CCR9. The reduction in intraepithelial T lymphocytes occurs within 7 wk of high-fat diet administration and is not dependent on chronic inflammation via TNF-alpha. Young mice administered a high-fat diet upon weaning exhibit the most dramatic phenotype, showing that childhood obesity has consequences on intestinal IEL seeding. Together, this dysfunction in the intestinal epithelium renders obese mice more susceptible to dextran sulfate sodium-induced colitis. Diet-induced weight loss restores IEL number and CD103/CCR9 expression and improves outcome in colitis. Together, these data confirm that obesity has immunomodulatory consequences in intestinal tissues that can be improved with weight loss. Copyright © 2019 by The American Association of Immunologists, Inc.
+Registry Number/Name of Substance
+ 0 (Antigens, CD). 0 (Biomarkers). 0 (CC chemokine receptor 9). 0 (Integrin alpha Chains). 0 (Receptors, CCR). 0 (Receptors, Tumor Necrosis Factor). 0 (alpha E integrins). 9042-14-2 (Dextran Sulfate).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.4049%2fjimmunol.1900082
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Park&issn=0022-1767&title=Journal+of+Immunology&atitle=Obesity+Modulates+Intestinal+Intraepithelial+T+Cell+Persistence%2C+CD103+and+CCR9+Expression%2C+and+Outcome+in+Dextran+Sulfate+Sodium-Induced+Colitis.&volume=203&issue=12&spage=3427&epage=3435&date=2019&doi=10.4049%2Fjimmunol.1900082&pmid=31712385&sid=OVID:medline
+
+<1981>
+Unique Identifier
+ 31695063
+Title
+ Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.
+Source
+ Scientific Reports. 9(1):16161, 2019 11 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Barkholt P; Rigbolt KTG; Falkenhahn M; Hubschle T; Schwahn U; Fernandez-Cachon ML; Schmidt T; Theis S; Hansen HH; Hay-Schmidt A; Pedersen PJ; Vrang N; Jelsing J
+Author NameID
+ Barkholt, Pernille; ORCID: http://orcid.org/0000-0002-3603-2915
+ Hansen, Henrik H; ORCID: http://orcid.org/0000-0002-3732-0281
+Authors Full Name
+ Barkholt, Pernille; Rigbolt, Kristoffer T G; Falkenhahn, Mechthilde; Hubschle, Thomas; Schwahn, Uwe; Fernandez-Cachon, Maria Luisa; Schmidt, Thorsten; Theis, Stefan; Hansen, Henrik H; Hay-Schmidt, Anders; Pedersen, Philip J; Vrang, Niels; Jelsing, Jacob.
+Institution
+ Barkholt, Pernille. Gubra, Horsholm, Denmark. pb@gubra.dk.
+ Barkholt, Pernille. Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark. pb@gubra.dk.
+ Rigbolt, Kristoffer T G. Gubra, Horsholm, Denmark.
+ Falkenhahn, Mechthilde. Sanofi-Aventis Deutschland GmbH, Frankfurt Am Main, Germany.
+ Hubschle, Thomas. Sanofi-Aventis Deutschland GmbH, Frankfurt Am Main, Germany.
+ Schwahn, Uwe. Sanofi-Aventis Deutschland GmbH, Frankfurt Am Main, Germany.
+ Fernandez-Cachon, Maria Luisa. Sanofi-Aventis Deutschland GmbH, Frankfurt Am Main, Germany.
+ Schmidt, Thorsten. Sanofi-Aventis Deutschland GmbH, Frankfurt Am Main, Germany.
+ Theis, Stefan. Sanofi-Aventis Deutschland GmbH, Frankfurt Am Main, Germany.
+ Hansen, Henrik H. Gubra, Horsholm, Denmark.
+ Hay-Schmidt, Anders. Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
+ Pedersen, Philip J. Gubra, Horsholm, Denmark.
+ Vrang, Niels. Gubra, Horsholm, Denmark.
+ Jelsing, Jacob. Gubra, Horsholm, Denmark.
+MeSH Subject Headings
+ Adiposity
+ Animals
+ *Arcuate Nucleus of Hypothalamus/me [Metabolism]
+ Astrocytes/me [Metabolism]
+ Biomarkers
+ Diet, High-Fat
+ *Diet, Reducing
+ Eating
+ *Gastric Bypass
+ *Gene Expression Profiling
+ *Gene Expression Regulation
+ Glial Fibrillary Acidic Protein/an [Analysis]
+ *Gliosis/ge [Genetics]
+ Glucagon-Like Peptide 1/bl [Blood]
+ Inflammation/ge [Genetics]
+ Laser Capture Microdissection
+ Male
+ Neuropeptides/bi [Biosynthesis]
+ Neuropeptides/ge [Genetics]
+ Obesity/et [Etiology]
+ Obesity/su [Surgery]
+ Peptide YY/bl [Blood]
+ Rats
+ Rats, Sprague-Dawley
+ Sequence Analysis, RNA
+ Weight Loss
+Abstract
+ The central mechanisms underlying the marked beneficial metabolic effects of bariatric surgery are unclear. Here, we characterized global gene expression in the hypothalamic arcuate nucleus (Arc) in diet-induced obese (DIO) rats following Roux-en-Y gastric bypass (RYGB). 60 days post-RYGB, the Arc was isolated by laser-capture microdissection and global gene expression was assessed by RNA sequencing. RYGB lowered body weight and adiposity as compared to sham-operated DIO rats. Discrete transcriptome changes were observed in the Arc following RYGB, including differential expression of genes associated with inflammation and neuropeptide signaling. RYGB reduced gene expression of glial cell markers, including Gfap, Aif1 and Timp1, confirmed by a lower number of GFAP immunopositive astrocyte profiles in the Arc. Sham-operated weight-matched rats demonstrated a similar glial gene expression signature, suggesting that RYGB and dietary restriction have common effects on hypothalamic gliosis. Considering that RYGB surgery also led to increased orexigenic and decreased anorexigenic gene expression, this may signify increased hunger-associated signaling at the level of the Arc. Hence, induction of counterregulatory molecular mechanisms downstream from the Arc may play an important role in RYGB-induced weight loss.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (GFAP protein, rat). 0 (Glial Fibrillary Acidic Protein). 0 (Neuropeptides). 106388-42-5 (Peptide YY). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-52257-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Barkholt&issn=2045-2322&title=Scientific+Reports&atitle=Global+transcriptome+analysis+of+rat+hypothalamic+arcuate+nucleus+demonstrates+reversal+of+hypothalamic+gliosis+following+surgically+and+diet+induced+weight+loss.&volume=9&issue=1&spage=16161&epage=&date=2019&doi=10.1038%2Fs41598-019-52257-8&pmid=31695063&sid=OVID:medline
+
+<1982>
+Unique Identifier
+ 31694556
+Title
+ Determinants of suboptimal long-term secondary prevention of acute myocardial infarction: the structural interview method and physical examinations.
+Source
+ BMC Cardiovascular Disorders. 19(1):243, 2019 11 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sakalaki M; Barywani S; Rosengren A; Bjorck L; Fu M
+Author NameID
+ Sakalaki, Maria; ORCID: https://orcid.org/0000-0003-4299-3672
+Authors Full Name
+ Sakalaki, Maria; Barywani, Salim; Rosengren, Annika; Bjorck, Lena; Fu, Michael.
+Institution
+ Sakalaki, Maria. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. maria.sakalaki@vgregion.se.
+ Sakalaki, Maria. Region Vastra Gotaland, Department of Medicine, Geriatrics and Emergency Medicine, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden. maria.sakalaki@vgregion.se.
+ Barywani, Salim. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Barywani, Salim. Region Vastra Gotaland, Department of Medicine, Geriatrics and Emergency Medicine, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Rosengren, Annika. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Rosengren, Annika. Region Vastra Gotaland, Department of Medicine, Geriatrics and Emergency Medicine, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+ Bjorck, Lena. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Fu, Michael. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
+ Fu, Michael. Region Vastra Gotaland, Department of Medicine, Geriatrics and Emergency Medicine, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Age Factors
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Diabetes Mellitus/di [Diagnosis]
+ Diabetes Mellitus/ep [Epidemiology]
+ Diabetes Mellitus/th [Therapy]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/ep [Epidemiology]
+ Dyslipidemias/th [Therapy]
+ Exercise
+ Female
+ Health Status
+ *Healthy Lifestyle
+ Humans
+ *Interviews as Topic
+ Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Mobility Limitation
+ Myocardial Infarction/di [Diagnosis]
+ Myocardial Infarction/ep [Epidemiology]
+ *Myocardial Infarction/pc [Prevention & Control]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/th [Therapy]
+ *Physical Examination
+ Predictive Value of Tests
+ Recurrence
+ Residence Characteristics
+ Retrospective Studies
+ Risk Assessment
+ Risk Factors
+ *Risk Reduction Behavior
+ *Secondary Prevention
+ Smoking/ae [Adverse Effects]
+ Smoking Cessation
+ Time Factors
+ Treatment Outcome
+ Unemployment
+ Weight Loss
+ Young Adult
+Keyword Heading
+ Cardiovascular disease
+ Diabetes
+ Myocardial infarction
+ Secondary prevention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Secondary prevention after an acute myocardial infarction (AMI) reduces morbidity and mortality, but suboptimal secondary prevention of cardiovascular disease is common. Therefore, the present study aimed to identify potential underlying factors for suboptimal secondary prevention 2 years after an AMI event.
+
+ METHODS: Patients aged 18-85 years at the time of their index AMI and hospitalized between July 2010 and December 2011, were identified retrospectively and consecutively from hospital discharge records. All patients who agreed to participate underwent a structured interview, physical examinations and laboratory analysis 2 years after their index AMI. The secondary preventive goals included are; blood pressure < 140/90 mmHg, LDL < 1.8 mmol/L, HbA1c < 48 mmol/mol, regular physical activity that causes sweating at least twice a week, non-smoking and BMI < 25 kg/m2. Multivariable and univariable logistic regression models were applied to identify independent predictors of different secondary prevention achievements.
+
+ RESULTS: Of the 200 patients (mean age 63.3 +/- 9.7 years) included in the study, 159 (80%) were men. No common determinants were found in patients who failed to achieve at least six secondary prevention guideline-directed goals. For individual secondary prevention goals, several determinants were defined. Patients born in Sweden were less likely to achieve optimal lipid control [odds ratio (OR) 0.28 (95% confidence interval, CI 0.12-0.63)]. Younger (<= 65 years) [OR 0.24 (95% CI 0.07-0.74)] and unemployed patients [OR 0.23 (95% CI 0.06-0.82)] were less likely to be non-smokers. Patients with diabetes mellitus [OR 0.21 (95% CI 0.04-0.98)] or with a walking aid [OR 0.23 (95% CI 0.07-0.71)] were less likely to achieve an optimal body mass index (BMI < 25). Living alone was an independent predictor of achieving regular physical activity [OR 1.94 (95% CI 1.02-3.69)].
+
+ CONCLUSION: Long-term secondary prevention remained suboptimal 2 years after an AMI. Causes are likely multifactorial, with no single determinant for all six guideline-recommended preventive goals. Therefore a tailored comprehensive assessment should be requested and updated and treatment of risk factors should be applied.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12872-019-1238-5
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sakalaki&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Determinants+of+suboptimal+long-term+secondary+prevention+of+acute+myocardial+infarction%3A+the+structural+interview+method+and+physical+examinations.&volume=19&issue=1&spage=243&epage=&date=2019&doi=10.1186%2Fs12872-019-1238-5&pmid=31694556&sid=OVID:medline
+
+<1983>
+Unique Identifier
+ 31689911
+Title
+ Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model.
+Source
+ Nutrients. 11(11), 2019 Nov 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cancelliere R; Leone S; Gatto C; Mazzoli A; Ercole C; Iossa S; Liverini G; Picone D; Crescenzo R
+Author NameID
+ Leone, Serena; ORCID: https://orcid.org/0000-0003-4787-0882
+ Iossa, Susanna; ORCID: https://orcid.org/0000-0001-6103-718X
+ Picone, Delia; ORCID: https://orcid.org/0000-0002-7582-2581
+ Crescenzo, Raffaella; ORCID: https://orcid.org/0000-0001-6138-6961
+Authors Full Name
+ Cancelliere, Rosa; Leone, Serena; Gatto, Cristina; Mazzoli, Arianna; Ercole, Carmine; Iossa, Susanna; Liverini, Giovanna; Picone, Delia; Crescenzo, Raffaella.
+Institution
+ Cancelliere, Rosa. Department of Biology, Federico II University, Via Cintia, 80126 Naples, Italy. cancelliererosa@gmail.com.
+ Leone, Serena. Department of Chemical Sciences, Federico II University, Via Cintia, 80126 Naples, Italy. serena.leone@unina.it.
+ Gatto, Cristina. Department of Biology, Federico II University, Via Cintia, 80126 Naples, Italy. cristina.gatto@unina.it.
+ Mazzoli, Arianna. Department of Biology, Federico II University, Via Cintia, 80126 Naples, Italy. arianna.mazzoli@unina.it.
+ Ercole, Carmine. Department of Chemical Sciences, Federico II University, Via Cintia, 80126 Naples, Italy. ercoleca@hotmail.com.
+ Iossa, Susanna. Department of Biology, Federico II University, Via Cintia, 80126 Naples, Italy. susanna.iossa@unina.it.
+ Liverini, Giovanna. Department of Biology, Federico II University, Via Cintia, 80126 Naples, Italy. liverini@unina.it.
+ Picone, Delia. Department of Chemical Sciences, Federico II University, Via Cintia, 80126 Naples, Italy. delia.picone@unina.it.
+ Crescenzo, Raffaella. Department of Biology, Federico II University, Via Cintia, 80126 Naples, Italy. rcrescen@unina.it.
+MeSH Subject Headings
+ Animals
+ Biomarkers/bl [Blood]
+ *Body Composition/de [Drug Effects]
+ Colon/de [Drug Effects]
+ *Diet, High-Fat
+ *Drinking Water
+ *Energy Metabolism/de [Drug Effects]
+ Glucose Tolerance Test
+ Inflammation
+ Lipids/bl [Blood]
+ Male
+ Muscle, Skeletal/de [Drug Effects]
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/me [Metabolism]
+ Pilot Projects
+ *Proteins/pd [Pharmacology]
+ Rats
+ Rats, Wistar
+ *Sweetening Agents/pd [Pharmacology]
+Keyword Heading
+ MNEI
+ fructose
+ high fat diet
+ sweet protein
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Sweeteners have become integrating components of the typical western diet, in response to the spreading of sugar-related pathologies (diabetes, obesity and metabolic syndrome) that have stemmed from the adoption of unbalanced dietary habits. Sweet proteins are a relatively unstudied class of sweet compounds that could serve as innovative sweeteners, but their introduction on the food market has been delayed by some factors, among which is the lack of thorough metabolic and toxicological studies. We have tried to shed light on the potential of a sweet protein, MNEI, as a fructose substitute in beverages in a typical western diet, by studying the metabolic consequences of its consumption on a Wistar rat model of high fat diet-induced obesity. In particular, we investigated the lipid profile, insulin sensitivity and other indicators of metabolic syndrome. We also evaluated systemic inflammation and potential colon damage. MNEI consumption rescued the metabolic derangement elicited by the intake of fructose, namely insulin resistance, altered plasma lipid profile, colon inflammation and translocation of lipopolysaccharides from the gut lumen into the circulatory system. We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Drinking Water). 0 (Lipids). 0 (Proteins). 0 (Sweetening Agents).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11112643
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cancelliere&issn=2072-6643&title=Nutrients&atitle=Metabolic+Effects+of+the+Sweet+Protein+MNEI+as+a+Sweetener+in+Drinking+Water.+A+Pilot+Study+of+a+High+Fat+Dietary+Regimen+in+a+Rodent+Model.&volume=11&issue=11&spage=&epage=&date=2019&doi=10.3390%2Fnu11112643&pmid=31689911&sid=OVID:medline
+
+<1984>
+Unique Identifier
+ 31681268
+Title
+ The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A Systematic Review and Meta-Analysis.
+Source
+ Frontiers in Immunology. 10:2349, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Song RH; Wang B; Yao QM; Li Q; Jia X; Zhang JA
+Authors Full Name
+ Song, Rong-Hua; Wang, Bin; Yao, Qiu-Ming; Li, Qian; Jia, Xi; Zhang, Jin-An.
+Institution
+ Song, Rong-Hua. Department of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
+ Wang, Bin. Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
+ Yao, Qiu-Ming. Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
+ Li, Qian. Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
+ Jia, Xi. Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
+ Zhang, Jin-An. Department of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
+MeSH Subject Headings
+ *Autoimmunity
+ Biomarkers
+ *Disease Susceptibility
+ Humans
+ *Obesity/co [Complications]
+ Odds Ratio
+ Thyroid Diseases/di [Diagnosis]
+ *Thyroid Diseases/et [Etiology]
+ Thyroid Diseases/me [Metabolism]
+ Thyroid Function Tests
+ *Thyroid Gland/im [Immunology]
+ Thyroid Gland/me [Metabolism]
+Keyword Heading
+ hypothyroidism
+ meta-analysis
+ obesity
+ systematic review
+ thyroid autoimmunity
+ thyroid disease
+ thyroid dysfunction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background: To help inform decision making in the clinical setting, we carried out a systematic review and meta-analysis to estimate the association of thyroid disease risks with obesity. Methods: Pubmed, Embase, Web of Science, Cochrane database and Google Scholar electronic databases were searched from inception to October 31, 2018 without language restrictions to explore the relationship between thyroid disorders and obesity. The relative risk (RR) or odds risk (OR) for thyroid disorders were pooled using the SPSS and STATA software. Results: A total of 22 studies were included in the study. (1) Meta-analysis showed that obesity was significantly associated with an increased risk of hypothyroidism (RR = 1.86, 95% CI 1.63-2.11, P < 0.001). Meta-analyses after stratification further showed that obese population had increased risks of overt hypothyroidism (RR = 3.21, 95% CI 2.12-4.86, P < 0.001) and subclinical hypothyroidism (RR = 1.70, 95% CI 1.42-2.03, P < 0.001). (2) Further meta-analysis also showed obesity was clearly associated with Hashimoto's thyroiditis (RR = 1.91, 95% CI 1.10-3.32, P = 0.022), but not with Graves' disease. (3) In the meta-analysis of antibodies, obesity was correlated with positive thyroid peroxidase antibody (TPOAb) (RR = 1.93, 95% CI 1.31-2.85, P = 0.001), but not with positive thyroglobulin antibody (TGAb). Conclusions: Obesity was significantly related to hypothyroidism, HT, and TPOAb, implying that prevention of obesity is crucial for thyroid disorders. Systematic Review Registration: PROSPERO: CRD42018096897. Copyright © 2019 Song, Wang, Yao, Li, Jia and Zhang.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3389%2ffimmu.2019.02349
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Song&issn=1664-3224&title=Frontiers+in+Immunology&atitle=The+Impact+of+Obesity+on+Thyroid+Autoimmunity+and+Dysfunction%3A+A+Systematic+Review+and+Meta-Analysis.&volume=10&issue=&spage=2349&epage=&date=2019&doi=10.3389%2Ffimmu.2019.02349&pmid=31681268&sid=OVID:medline
+
+<1985>
+Unique Identifier
+ 31677709
+Title
+ Early markers of endocrinometabolic disease in newborns with delayed intrauterine growth.
+Source
+ Clinical Nutrition ESPEN. 34:37-44, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alonso-Larruscain IS; Ruibal Francisco JL; Granizo Martinez JJ; Garcia-Garcia ML; Fuentes Ferrer ME
+Authors Full Name
+ Alonso-Larruscain, I S; Ruibal Francisco, J L; Granizo Martinez, J J; Garcia-Garcia, M L; Fuentes Ferrer, M E.
+Institution
+ Alonso-Larruscain, I S. Hospital Universitario Severo Ochoa, Leganes, Spain. Electronic address: ingealo@yahoo.es.
+ Ruibal Francisco, J L. Hospital Universitario Infanta Cristina, Parla, Spain. Electronic address: jlruibalf@salud.madrid.org.
+ Granizo Martinez, J J. Hospital Universitario Infanta Cristina, Parla, Spain. Electronic address: juanjose.granizo@salud.madrid.org.
+ Garcia-Garcia, M L. Hospital Universitario Severo Ochoa, Leganes, Spain. Electronic address: marialuz.hso@gmail.com.
+ Fuentes Ferrer, M E. Hospital Universitario Clinico San Carlos, Madrid, Spain. Electronic address: mfuentesferrer@gmail.com.
+MeSH Subject Headings
+ Anthropometry
+ *Biomarkers/bl [Blood]
+ Birth Weight
+ Blood Glucose
+ Cholesterol/bl [Blood]
+ Cholesterol, HDL/bl [Blood]
+ Female
+ Fetal Blood
+ *Fetal Growth Retardation/bl [Blood]
+ *Fetal Growth Retardation/di [Diagnosis]
+ Gestational Age
+ Humans
+ Infant, Newborn
+ Insulin/bl [Blood]
+ Insulin Resistance
+ Insulin-Like Growth Factor Binding Protein 3/bl [Blood]
+ Insulin-Like Growth Factor I/me [Metabolism]
+ Male
+ *Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Pregnancy
+ Prospective Studies
+ Triglycerides/bl [Blood]
+Keyword Heading
+ Fetal growth retardation
+ Growth
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: The adjustments to malnutrition in growth restricted fetus (GRF) that lead to obesity, insulin resistance, diabetes and cardiovascular disease in adulthood are not well known. The most feasible explanation for this association is the hypothesis of catch up. Some studies postulate a greater influence of catch up growth than the low birth weight itself in developing metabolic and cardiovascular disease.
+
+ MATERIAL AND METHODS: This is a prospective cohort study of newborns with intrauterine growth restriction (defined as weight percentile at birth less than 10th) born during a one-year period. Clinical data of patients were recorded (gender, gestational age, data about breastfeeding and anthropometry during follow-up every 3 months). Some details of pregnancy and characteristics of the mother were also registered. Serum biochemical parameters (IGF-1, IGF-BP3, insulin, glucose, total cholesterol, HDL cholesterol, DLD cholesterol, triglycerides, HOMA) were collected at birth from cord blood, 9 and 12 months. Two main comparative groups were established: those GRF who made a catch-up growth (increase in weight Z score higher than 0,67) during the follow-up and those who did not get it.
+
+ RESULTS: 126 GRF children were born in the study period. 125 accepted the inclusion in the study and 67 of them completed the full monitoring for a year; 47 of them made recovery growth and 20 did not. A significant difference between both groups was found in glucose in umbilical cord and triglycerides at 12 months: GRF children with catch up growth showed lower glucose levels (p = 0.03) and higher levels of triglycerides (p = 0.03). There were no statistically significant differences in the rest of laboratory parameters analyzed (IGF-1, IGF-BP3, insulin, glucose, total cholesterol, HDL cholesterol, DLD cholesterol, HOMA at 9 and 12 months or triglycerides at 9 months).
+
+ CONCLUSIONS: Those GRF with catch up growth during the first year of life have early changes in the triglycerides at the end of that period with higher levels than those GRF children without catch up growth. This finding could be useful to develop a tool for early detection of GRF children with higher metabolic risk in order to prevent future pathology. Copyright © 2019 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (IGF1 protein, human). 0 (IGFBP3 protein, human). 0 (Insulin). 0 (Insulin-Like Growth Factor Binding Protein 3). 0 (Triglycerides). 67763-96-6 (Insulin-Like Growth Factor I). 97C5T2UQ7J (Cholesterol).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.clnesp.2019.09.006
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alonso-Larruscain&issn=2405-4577&title=Clinical+Nutrition+ESPEN&atitle=Early+markers+of+endocrinometabolic+disease+in+newborns+with+delayed+intrauterine+growth.&volume=34&issue=&spage=37&epage=44&date=2019&doi=10.1016%2Fj.clnesp.2019.09.006&pmid=31677709&sid=OVID:medline
+
+<1986>
+Unique Identifier
+ 31672146
+Title
+ Short-term treatment with high dose liraglutide improves lipid and lipoprotein profile and changes hormonal mediators of lipid metabolism in obese patients with no overt type 2 diabetes mellitus: a randomized, placebo-controlled, cross-over, double-blind clinical trial.
+Source
+ Cardiovascular Diabetology. 18(1):141, 2019 10 31.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Peradze N; Farr OM; Perakakis N; Lazaro I; Sala-Vila A; Mantzoros CS
+Author NameID
+ Mantzoros, Christos S; ORCID: https://orcid.org/0000-0003-3755-8158
+Authors Full Name
+ Peradze, Natia; Farr, Olivia M; Perakakis, Nikolaos; Lazaro, Iolanda; Sala-Vila, Aleix; Mantzoros, Christos S.
+Institution
+ Peradze, Natia. Division of Endocrinology, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave, SL419, Boston, MA, 02215, USA.
+ Farr, Olivia M. Division of Endocrinology, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave, SL419, Boston, MA, 02215, USA.
+ Perakakis, Nikolaos. Division of Endocrinology, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave, SL419, Boston, MA, 02215, USA.
+ Lazaro, Iolanda. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Lazaro, Iolanda. Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Villarroel 170, 08036, Barcelona, Spain.
+ Sala-Vila, Aleix. CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
+ Sala-Vila, Aleix. Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Villarroel 170, 08036, Barcelona, Spain.
+ Mantzoros, Christos S. Division of Endocrinology, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave, SL419, Boston, MA, 02215, USA. cmantzor@bidmc.harvard.edu.
+ Mantzoros, Christos S. Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, 150 South Huntington Avenue, Boston, MA, 02130, USA. cmantzor@bidmc.harvard.edu.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Boston
+ Cross-Over Studies
+ Double-Blind Method
+ Drug Administration Schedule
+ Female
+ *Follistatin/bl [Blood]
+ Humans
+ *Incretins/ad [Administration & Dosage]
+ Incretins/ae [Adverse Effects]
+ *Inhibin-beta Subunits/bl [Blood]
+ *Lipid Metabolism/de [Drug Effects]
+ *Lipids/bl [Blood]
+ *Lipoproteins/bl [Blood]
+ *Liraglutide/ad [Administration & Dosage]
+ Liraglutide/ae [Adverse Effects]
+ Male
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dt [Drug Therapy]
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ Cardio-vascular disease
+ Diabetes
+ Dyslipidemia
+ GLP-1
+ Lipoproteins
+ Liraglutide
+ Metabolites
+ Metabolomics
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Long-term treatment with up to 1.8 mg liraglutide improves cardiovascular and all-cause mortality in patients with type 2 diabetes at high risk for cardiovascular disease (CVD) and is currently under investigation in subjects without diabetes. Aim of our study was to investigate whether high dose (3 mg) short-term (5 weeks) treatment with liraglutide in obese patients with no overt type 2 diabetes affects metabolites, lipid and lipoprotein profile and components of activin-follistatin axis in cardiovascular beneficial or detrimental way.
+
+ RESEARCH DESIGN AND METHODS: Twenty obese patients participated in a randomized, placebo-controlled, cross-over, double-blind study and were administrated liraglutide 3 mg or placebo for 5 weeks. Metabolites, fatty acids, lipid-lipoprotein profile and concentrations of activins and follistatins (250 parameters) were assessed in serum at start and completion of each treatment.
+
+ RESULTS: Concentrations of important cardiovascular markers such as total, free and remnant cholesterol were reduced with liraglutide before and after adjusting for weight loss. Similarly, reductions in number of small and medium size LDL particles and in their total lipid concentration were observed with liraglutide and partially weight-loss related. Tyrosine levels were reduced and behenic acid levels were increased whereas only minor changes were observed in HDL, VLDL and IDL. Concentrations of activin AB and follistatin were significantly reduced in liraglutide-treated group.
+
+ CONCLUSIONS: Treatment of obese patients without overt type 2 diabetes with high dose of liraglutide for a short period of time induces changes in lipid-lipoprotein and hormonal profile that are suggestive of lower risk of atherosclerosis and CVD. Trial registration ClinicalTrials.gov Identifier: NCT02944500. Study ID Number 2015P000327. Registered November 2016.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (FST protein, human). 0 (Follistatin). 0 (INHBB protein, human). 0 (Incretins). 0 (Lipids). 0 (Lipoproteins). 839I73S42A (Liraglutide). 93443-12-0 (Inhibin-beta Subunits).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12933-019-0945-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Peradze&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Short-term+treatment+with+high+dose+liraglutide+improves+lipid+and+lipoprotein+profile+and+changes+hormonal+mediators+of+lipid+metabolism+in+obese+patients+with+no+overt+type+2+diabetes+mellitus%3A+a+randomized%2C+placebo-controlled%2C+cross-over%2C+double-blind+clinical+trial.&volume=18&issue=1&spage=141&epage=&date=2019&doi=10.1186%2Fs12933-019-0945-7&pmid=31672146&sid=OVID:medline
+
+<1987>
+Unique Identifier
+ 31668791
+Title
+ Prevalence of obesity and obesity-associated muscle wasting in patients on peritoneal dialysis.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 29(12):1390-1399, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Guida B; Trio R; Di Maro M; Memoli A; Di Lauro T; Belfiore A; Santillo M; Cataldi M
+Authors Full Name
+ Guida, Bruna; Trio, Rossella; Di Maro, Martina; Memoli, Andrea; Di Lauro, Teresa; Belfiore, Annamaria; Santillo, Mariarosaria; Cataldi, Mauro.
+Institution
+ Guida, Bruna. Department of Clinical Medicine and Surgery, Physiology Nutrition Unit, Federico II University of Naples, Italy. Electronic address: bguida@unina.it.
+ Trio, Rossella. Department of Clinical Medicine and Surgery, Physiology Nutrition Unit, Federico II University of Naples, Italy.
+ Di Maro, Martina. Department of Clinical Medicine and Surgery, Physiology Nutrition Unit, Federico II University of Naples, Italy.
+ Memoli, Andrea. Department of Public Health, Nephrology Section, Federico II University of Naples, Italy.
+ Di Lauro, Teresa. Department of Clinical Medicine and Surgery, Physiology Nutrition Unit, Federico II University of Naples, Italy.
+ Belfiore, Annamaria. Department of Clinical Medicine and Surgery, Physiology Nutrition Unit, Federico II University of Naples, Italy.
+ Santillo, Mariarosaria. Department of Clinical Medicine and Surgery, Physiology Nutrition Unit, Federico II University of Naples, Italy.
+ Cataldi, Mauro. Department of Neuroscience, Reproductive Sciences and Dentistry, Division of Pharmacology, Federico II University of Naples, Italy.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Body Composition
+ C-Reactive Protein
+ Cross-Sectional Studies
+ Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Fibrinogen
+ Humans
+ Inflammation Mediators/bl [Blood]
+ Italy/ep [Epidemiology]
+ Kidney Failure, Chronic/di [Diagnosis]
+ Kidney Failure, Chronic/ep [Epidemiology]
+ Kidney Failure, Chronic/pp [Physiopathology]
+ *Kidney Failure, Chronic/th [Therapy]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ *Peritoneal Dialysis/ae [Adverse Effects]
+ Prevalence
+ Risk Assessment
+ Risk Factors
+ Sarcopenia/bl [Blood]
+ Sarcopenia/di [Diagnosis]
+ *Sarcopenia/ep [Epidemiology]
+ Sarcopenia/pp [Physiopathology]
+Keyword Heading
+ BIA
+ BIVA
+ Muscle wasting
+ Obesity
+ Peritoneal dialysis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIMS: A progressive decrease in muscle mass until full-blown sarcopenia may occur in patients on peritoneal dialysis (PD) and worsen their life quality and expectancy. Here we investigate the prevalence of obesity and obesity-associated muscle wasting in PD patients.
+
+ PATIENTS AND METHODS: The study design was observational, cross sectional. Body composition was assessed with BIA and BIVA in 88 PD patients (53.4 +/- 13.1 years; 67% male). Patients with obesity and/or with reduced muscle mass were identified using FMI and SM/BW cutoff values, respectively. Inflammatory status was assessed by measuring CRP and fibrinogen blood levels.
+
+ RESULTS: A total of 44.3% of the patients showed a reduced muscle mass (37.5% moderate and 6.8% severe). The prevalence of obesity was 6.1%, 81.8%, and 100% in patients with normal, moderately, and severely reduced muscle mass, respectively (p < 0.05). Of the total, 15.2% of the patients with normal muscle mass, 18.4% of those with moderately reduced muscle mass, and 66.7% of those with severely reduced muscle mass had diabetes. The prevalence of severe muscle mass loss was higher in those with diabetes than in those without diabetes (22.2% vs. 2.8%, p < 0.05). Patients with obesity-associated muscle wasting showed higher fibrinogen (613.9 +/- 155.1 vs. 512.9 +/- 159.5 mg/dL, p < 0.05) and CPR (1.4 +/- 1.3 vs. 0.6 +/- 0.8 mg/dL, p < 0.05) blood concentrations than those with normal body composition.
+
+ CONCLUSION: Obesity and diabetes were strongly associated with muscle mass loss in our PD patients. It remains to be established whether prevention of obesity with nutritional interventions can halt the occurrence of muscle mass loss in patients on PD. Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 9001-32-5 (Fibrinogen). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.numecd.2019.05.057
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Guida&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=Prevalence+of+obesity+and+obesity-associated+muscle+wasting+in+patients+on+peritoneal+dialysis.&volume=29&issue=12&spage=1390&epage=1399&date=2019&doi=10.1016%2Fj.numecd.2019.05.057&pmid=31668791&sid=OVID:medline
+
+<1988>
+Unique Identifier
+ 31668385
+Title
+ Interaction of circulating GLP-1 and the response of the dorsolateral prefrontal cortex to food-cues predicts body weight development.
+Source
+ Molecular Metabolism. 29:136-144, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Maurer L; Mai K; Krude H; Haynes JD; Weygandt M; Spranger J
+Authors Full Name
+ Maurer, Lukas; Mai, Knut; Krude, Heiko; Haynes, John-Dylan; Weygandt, Martin; Spranger, Joachim.
+Institution
+ Maurer, Lukas. Charite - Universitatsmedizin Berlin, Clinic of Endocrinology, Diabetes and Metabolism, Berlin, Germany; Charite - Universitatsmedizin Berlin, Charite Center for Cardiovascular Research, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; Charite - Universitatsmedizin Berlin, DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany. Electronic address: lukas.maurer@charite.de.
+ Mai, Knut. Charite - Universitatsmedizin Berlin, Clinic of Endocrinology, Diabetes and Metabolism, Berlin, Germany; Charite - Universitatsmedizin Berlin, DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
+ Krude, Heiko. Charite - Universitatsmedizin Berlin, Clinic of Pediatric Endocrinology and Diabetology, Berlin, Germany.
+ Haynes, John-Dylan. Charite - Universitatsmedizin Berlin, Excellence Cluster NeuroCure, Berlin, Germany; Charite - Universitatsmedizin Berlin, Berlin Center for Advanced Neuroimaging, Department of Neurology, Berlin, Germany.
+ Weygandt, Martin. Charite - Universitatsmedizin Berlin, Excellence Cluster NeuroCure, Berlin, Germany; Charite - Universitatsmedizin Berlin, Berlin Center for Advanced Neuroimaging, Department of Neurology, Berlin, Germany.
+ Spranger, Joachim. Charite - Universitatsmedizin Berlin, Clinic of Endocrinology, Diabetes and Metabolism, Berlin, Germany; Charite - Universitatsmedizin Berlin, Charite Center for Cardiovascular Research, Berlin, Germany; Charite - Universitatsmedizin Berlin, DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Body Weight/ph [Physiology]
+ Brain/dg [Diagnostic Imaging]
+ Caloric Restriction
+ Cues
+ Female
+ *Glucagon-Like Peptide 1/bl [Blood]
+ Humans
+ Linear Models
+ Magnetic Resonance Imaging
+ Male
+ Middle Aged
+ Obesity/pa [Pathology]
+ Photic Stimulation
+ *Prefrontal Cortex/me [Metabolism]
+ Weight Loss
+Keyword Heading
+ Body weight regulation
+ DLPFC
+ Food-cue reactivity
+ GLP-1
+ Obesity
+ Voxel-wise linear mixed-effects regression
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVES: This study evaluated the impact of the interaction between the anorexigenic incretin hormone glucagon-like peptide-1 (GLP-1) and reward-related brain activity in the dorsolateral prefrontal cortex (DLPFC), a key area of behavioral control, on future weight loss in obese individuals.
+
+ METHODS: We performed a weight loss-weight maintenance intervention study over 27 months. We applied an fMRI food-cue reactivity paradigm during which the participants were passively exposed to food pictures to evaluate neuronal activity in the DLPFC. Additionally, we measured concentrations of circulating GLP-1 levels during a standard oral glucose tolerance test. Phenotyping was performed consecutively before and after a 3-month low-calorie diet as well as after a randomized 12-month trial, investigating the effect of a combined behavioral intervention on body weight maintenance. Participants were then followed-up for another 12 months without further intervention.
+
+ RESULTS: Using voxel-wise linear mixed-effects regression analyses, we evaluated 56 measurements and identified a strong interaction between circulating, endogenous GLP-1 levels and DLPFC activity predicting body weight change over the total observation period (t = -6.17, p = 1.6 . 10-7). While neither the GLP-1 nor the DLPFC response individually predicted the subsequent weight change, participants achieved body weight loss when the GLP-1 and the DLPFC responses occurred concurrently.
+
+ CONCLUSIONS: Our data demonstrate an interaction between a peripheral hormonal signal and central nervous activity as robust predictor of body weight change throughout the different periods of a long-term life-style intervention. The preeminent role of their interdependency compared to the partly ambivalent effects of the single components argues for integrative approaches to improve sensitivity and reliability of weight prediction conventionally based on individual biomarkers. Copyright © 2019 The Authors. Published by Elsevier GmbH.. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.molmet.2019.08.014
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Maurer&issn=2212-8778&title=Molecular+Metabolism&atitle=Interaction+of+circulating+GLP-1+and+the+response+of+the+dorsolateral+prefrontal+cortex+to+food-cues+predicts+body+weight+development.&volume=29&issue=&spage=136&epage=144&date=2019&doi=10.1016%2Fj.molmet.2019.08.014&pmid=31668385&sid=OVID:medline
+
+<1989>
+Unique Identifier
+ 31659957
+Title
+ Triglycerides-to-HDLC Ratio as a Marker of Cardiac Disease and Vascular Risk Factors in Adults.
+Source
+ Jcpsp, Journal of the College of Physicians & Surgeons - Pakistan. 29(11):1034-1037, 2019 Nov.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ain QU; Asif N; Alam A; Gilani M; Noreen Shahzad; Sheikh W
+Authors Full Name
+ Ain, Qurat Ul; Asif, Naveed; Alam, Amir; Gilani, Mehwish; Noreen Shahzad; Sheikh, Waqas.
+Institution
+ Ain, Qurat Ul. Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan.
+ Asif, Naveed. Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan.
+ Alam, Amir. Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan.
+ Gilani, Mehwish. Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan.
+ Noreen, Shahzad. Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan.
+ Sheikh, Waqas. Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Cardiovascular Diseases/bl [Blood]
+ *Cholesterol, HDL/bl [Blood]
+ Cross-Sectional Studies
+ Diabetes Mellitus/bl [Blood]
+ Female
+ Humans
+ Hypertension/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Predictive Value of Tests
+ Risk Factors
+ *Triglycerides/bl [Blood]
+Abstract
+ OBJECTIVE: To find out correlation of triglycerides-to-HDL cholesterol ratio in elders with cardiac risk factors like obesity, diabetes, and hypertension.
+
+ STUDY DESIGN: Observational cross-sectional study.
+
+ PLACE AND DURATION OF STUDY: Department of Chemical Pathology and Endocrinology, Combined Military Hospital, Rawalpindi, from January to June 2018.
+
+ METHODOLOGY: Inclusion standards were participants aged 20-59 years .Patients with comorbidity and chronic illness were excluded from the study. A planned standardised homogeneous survey was conducted as a pilot study. Social, economic and physical variables like age, gender, marital status and presence of diseases, all were taken into consideration. To check association among cardio metabolic risk factors like diabetes, obesity, hypertension, and TG/HDL-C ratio, Chi-square test was computed for all cardio metabolic risk factors.
+
+ RESULTS: Overall 350 participants were studied after attainment of authorisation from Ethical Review Board of Combined Military Hospital, Rawalpindi, in which 268 (76.6%) were women; whereas, 82 (23.4%) were men with mean age of 37 +/- 11.64 years. There was strong association of TG/HDL ratio with BMI, HOMA-IR, WBISI, visceral fats, smooth muscle mass, HDL, LDL, and triglycerides with p <0.04, p <0.001, p <0.01, and p <0.001, respectively.
+
+ CONCLUSION: TG/HDLC ratio can be considered as a potential biomarker for the early prediction of cardiometablic risk factors.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, HDL). 0 (Triglycerides).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.29271%2fjcpsp.2019.11.1034
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ain&issn=1022-386X&title=Jcpsp%2C+Journal+of+the+College+of+Physicians+%26+Surgeons+-+Pakistan&atitle=Triglycerides-to-HDLC+Ratio+as+a+Marker+of+Cardiac+Disease+and+Vascular+Risk+Factors+in+Adults.&volume=29&issue=11&spage=1034&epage=1037&date=2019&doi=10.29271%2Fjcpsp.2019.11.1034&pmid=31659957&sid=OVID:medline
+
+<1990>
+Unique Identifier
+ 31654268
+Title
+ Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations.
+Source
+ GeroScience. 41(6):923-933, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kavanagh K; Hsu FC; Davis AT; Kritchevsky SB; Rejeski WJ; Kim S
+Author NameID
+ Kavanagh, Kylie; ORCID: http://orcid.org/0000-0001-8772-6186
+Authors Full Name
+ Kavanagh, Kylie; Hsu, Fang-Chi; Davis, Ashley T; Kritchevsky, Stephen B; Rejeski, W Jack; Kim, Sunghye.
+Institution
+ Kavanagh, Kylie. Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1009, USA. kkavanag@wakehealth.edu.
+ Kavanagh, Kylie. School of Medicine, University of Tasmania, TAS, Hobart, Australia. kkavanag@wakehealth.edu.
+ Hsu, Fang-Chi. Division of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+ Davis, Ashley T. Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1009, USA.
+ Kritchevsky, Stephen B. Sticht Center on Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+ Rejeski, W Jack. Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.
+ Kim, Sunghye. Department of Internal Medicine, Section of Rheumatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
+MeSH Subject Headings
+ Aged
+ *Aging
+ Biomarkers/me [Metabolism]
+ *Exercise Therapy/mt [Methods]
+ Female
+ Follow-Up Studies
+ Humans
+ Inflammation/co [Complications]
+ *Inflammation/me [Metabolism]
+ Male
+ Metabolic Syndrome/et [Etiology]
+ *Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pp [Physiopathology]
+ Middle Aged
+ *Mobility Limitation
+ *Motor Activity/ph [Physiology]
+ *Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Obesity/th [Therapy]
+ Retrospective Studies
+ Weight Loss/ph [Physiology]
+Keyword Heading
+ Ageing
+ Lipopolysaccharide-binding protein
+ Microbial translocation
+ Physical function
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Intestinal barrier dysfunction is hypothesized to be a contributing determinant of two prominent characteristics of aging: inflammation and decline in physical function. A relationship between microbial translocation (MT), or their biomarkers (lipopolysaccharide binding protein-1 [LBP-1], soluble cluster of differentiation [sCD]-14), and physical function has been reported in healthy older adults, rats, and invertebrates. However, it is not known whether the existence of comorbidities, or clinical interventions intended to reduce comorbidities through weight loss or exercise, alters this connection. We measured inflammation, MT, and physical function in 288 overweight/obese older patients with cardiometabolic disease and self-reported mobility limitations who were enrolled in a weight loss and lifestyle intervention study. At baseline, inflammatory cytokines and LBP-1 were positively correlated after adjustment for age, gender, and body mass index. A higher LBP-1 was significantly associated with poorer physical functional after covariate adjustment. Further, even when IL-6 levels were included in the models, 400-m walk time (p = 0.003), short physical performance battery (p = 0.07), and IL-8 (p < 0.001) remained positively associated with LBP-1. Lifestyle interventions improved body mass and some functional measures; however, MT and inflammation were unchanged. MT is reliably related to inflammation, and to poorer physical function in older adults with comorbid conditions. Intestinal barrier function did not appear to improve as a result of intervention assignment, suggesting alternative strategies are needed to target this pro-inflammatory pathway in aging.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11357-019-00112-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kavanagh&issn=2509-2723&title=GeroScience&atitle=Biomarkers+of+leaky+gut+are+related+to+inflammation+and+reduced+physical+function+in+older+adults+with+cardiometabolic+disease+and+mobility+limitations.&volume=41&issue=6&spage=923&epage=933&date=2019&doi=10.1007%2Fs11357-019-00112-z&pmid=31654268&sid=OVID:medline
+
+<1991>
+Unique Identifier
+ 31652762
+Title
+ Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Defining Body Weight.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 16(21), 2019 10 23.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nowicki GJ; Slusarska B; Prystupa A; Polak M; Czubaj-Kowal M; Rudnicka-Drozak E
+Author NameID
+ Nowicki, Grzegorz Jozef; ORCID: https://orcid.org/0000-0002-0503-8847
+ Slusarska, Barbara; ORCID: https://orcid.org/0000-0003-0101-9216
+ Prystupa, Andrzej; ORCID: https://orcid.org/0000-0003-4628-8911
+Authors Full Name
+ Nowicki, Grzegorz Jozef; Slusarska, Barbara; Prystupa, Andrzej; Polak, Maciej; Czubaj-Kowal, Maria; Rudnicka-Drozak, Ewa.
+Institution
+ Nowicki, Grzegorz Jozef. Department of Family Medicine and Community Nursing, Medical University of Lublin, Staszica 6 Str., PL-20-081 Lublin, Poland. gnowicki84@gmail.com.
+ Slusarska, Barbara. Department of Family Medicine and Community Nursing, Medical University of Lublin, Staszica 6 Str., PL-20-081 Lublin, Poland. basiaslusarska@gmail.com.
+ Prystupa, Andrzej. Department of Internal Medicine, Medical University of Lublin, Staszica 16 Str., PL-20-081 Lublin, Poland. aprystup@wp.pl.
+ Polak, Maciej. Department of Epidemiology and Population Studies, Jagiellonian University Medical College, Grzegorzecka 20 Str., PL-31-531 Cracow, Poland. maciej.1.polak@uj.edu.pl.
+ Czubaj-Kowal, Maria. Department of Pediatrics, St. Zeromski Hospital of Cracow, Na Skarpie 66 Str., 31-913 Cracow, Poland. martacz58@gmail.com.
+ Rudnicka-Drozak, Ewa. Department of Family Medicine, Medical University of Lublin, Langiewicza 6A Str., PL-20-032 Lublin, Poland. edrozak@poczta.onet.pl.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ *Adiposity/ph [Physiology]
+ Adult
+ Aged
+ *Antioxidants/me [Metabolism]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ *Body Weight/ph [Physiology]
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ Humans
+ Male
+ Middle Aged
+ Myocardial Infarction/bl [Blood]
+ *Myocardial Infarction/pp [Physiopathology]
+ Obesity/bl [Blood]
+ *Obesity/pp [Physiopathology]
+ *Oxidants/bl [Blood]
+ *Oxidative Stress/ph [Physiology]
+Keyword Heading
+ antioxidant status
+ cardiovascular diseases
+ obesity
+ overweight
+ oxidative status
+ oxidative stress
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is one of the factors leading to the development of atherosclerosis. This metabolic disorder is associated with an increased production of reactive oxygen species, which affect the oxidative stress levels. The aim of this study was to evaluate oxidative/antioxidative status and to investigate the correlation between redox markers and anthropometric parameters and body composition in adult patients after myocardial infarction and in individuals without a cardiovascular event in the past. Descriptive data on socio-demographic, clinical, and anthropometric features and blood samples were collected and categorized into two equal groups: after myocardial infarction (study group (SG), n = 80) and without a cardiovascular event (control group (CG), n = 80). The oxidative/antioxidative status was assessed in plasma on the basis of total oxidative/capacitive status (PerOx), total antioxidative status/capacity (ImAnOx), and oxidized low-density lipoprotein (oxLDL). The oxLDL was significantly higher in the CG group compared to the SG group (p = 0.02). No significant differences were found with regard to PerOx and ImAnOx values between the groups studied. A significant positive correlation between PerOx and percentage of adipose tissue (FM%) and body adiposity index (BAI) was found in the two studied groups. ImAnOx significantly positively correlated with visceral adiposity indexes(VAIs) in SG and FM% in CG. OxLDL negatively correlated with body mass index and waist to hip circumference ratio in CG. The total oxidative/antioxidative status is related to the amount of adipose tissue and the BAIs of the subjects. It was observed that it correlates more frequently with the visceral distribution of body fat.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Oxidants).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijerph16214077
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nowicki&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Oxidative%2FAntioxidative+Status+in+Patients+after+Myocardial+Infarction+and+in+Those+without+Cardiovascular+Event+Depending+on+Anthropometric+Factors+Defining+Body+Weight.&volume=16&issue=21&spage=&epage=&date=2019&doi=10.3390%2Fijerph16214077&pmid=31652762&sid=OVID:medline
+
+<1992>
+Unique Identifier
+ 31649216
+Title
+ Association of -174 G>C interleukin-6 gene polymorphism with interleukin-6 and c-reactive protein levels and obesity: A case-control study among people/residents of Western Indonesia.
+Source
+ Medical Journal of Malaysia. 74(5):400-404, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pramudji H; Demes CM; Dewi K; Tasmini T; Ahmad HS
+Authors Full Name
+ Pramudji, H; Demes, C M; Dewi, K; Tasmini, T; Ahmad, H S.
+Institution
+ Pramudji, H. Universitas Gadjah Mada, Faculty of Medicine, Public Health and Nursing, Department of Biochemistry, Yogyakarta, Indonesia. pramudji.has@ugm.ac.id.
+ Demes, C M. Universitas Maranatha, Faculty of Medicine, Bandung, Indonesia.
+ Dewi, K. Universitas Muhammadiyah Purwokerto, Faculty of Medicine, Department of Biochemistry, Jawa Tengah, Indonesia.
+ Tasmini, T. Universitas Gadjah Mada, Faculty of Medicine, Public Health and Nursing, Department of Biochemistry, Yogyakarta, Indonesia.
+ Ahmad, H S. Universitas Gadjah Mada, Faculty of Medicine, Public Health and Nursing, Department of Biochemistry, Yogyakarta, Indonesia.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ *C-Reactive Protein/me [Metabolism]
+ *DNA/ge [Genetics]
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ Genotype
+ Humans
+ Incidence
+ Indonesia/ep [Epidemiology]
+ Interleukin-6/bl [Blood]
+ *Interleukin-6/ge [Genetics]
+ Male
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ *Polymorphism, Genetic
+ Retrospective Studies
+ Risk Factors
+ Young Adult
+Abstract
+ BACKGROUND: Interleukin-6 (IL-6) and C-Reactive Protein (CRP) are mediators of inflammatory responses and increase in people who are obese . The increase of IL-6 and CRP levels is modified by polymorphism of -174 G>C IL-6 gene.
+
+ AIM: The purpose of this study was to investigate the relationship between -174 G>C IL-6 polymorphism gene on the level of IL-6 and CRP in the population of western Indonesia obese who are obese.
+
+ METHODS: In this study, we examined 178 subjects consisting of 89 who are obese with BMI> 25, and controls with BMI between 18.5 and 23. Fasting blood was taken from each subject for the examination of IL-6 and CRP levels by the ELISA method. Determination of genotype -174 G>C IL-6 gene was examined by Polymerase Chain reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) methods.
+
+ RESULTS: The results of this study showed increased levels of IL-6 and CRP in the obese group compared to the controls. In the obese group, CC genotype had higher CRP and lower IL-6 levels than the GC and GG genotypes. The frequency of CC genotype in the obese group was 47.2% compared with 28.1% in controls and this genotype was considered a risk factor for obesity. Carriers of the C genotype as a dominant or a recessive model had greater risk of obesity.
+
+ CONCLUSION: It was concluded that the polymorphism - 174G>C IL-6 gene is a risk factor for obesity and is associated with increased levels of IL-6 and CRP in an obese group of the Western Indonesian ethnic population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Interleukin-6). 9007-41-4 (C-Reactive Protein). 9007-49-2 (DNA).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&AN=31649216
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pramudji&issn=0300-5283&title=Medical+Journal+of+Malaysia&atitle=Association+of+-174+G%3EC+interleukin-6+gene+polymorphism+with+interleukin-6+and+c-reactive+protein+levels+and+obesity%3A+A+case-control+study+among+people%2Fresidents+of+Western+Indonesia.&volume=74&issue=5&spage=400&epage=404&date=2019&doi=&pmid=31649216&sid=OVID:medline
+
+<1993>
+Unique Identifier
+ 31648221
+Title
+ Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature.
+Source
+ PLoS ONE [Electronic Resource]. 14(10):e0224103, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jee YH; Lee KS; Yue S; Leschek EW; Boden MG; Jadra A; Klibanski A; Vaidyanathan P; Misra M; Chang YP; Yanovski JA; Baron J
+Author NameID
+ Chang, Young Pyo; ORCID: https://orcid.org/0000-0002-5262-6561
+ Baron, Jeffrey; ORCID: https://orcid.org/0000-0002-7311-9112
+Authors Full Name
+ Jee, Youn Hee; Lee, Kun Song; Yue, Shanna; Leschek, Ellen W; Boden, Matthew G; Jadra, Aysha; Klibanski, Anne; Vaidyanathan, Priya; Misra, Madhusmita; Chang, Young Pyo; Yanovski, Jack A; Baron, Jeffrey.
+Institution
+ Jee, Youn Hee. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.
+ Lee, Kun Song. Pediatrics, Dankook University Hospital, Cheonan, Republic of Korea.
+ Yue, Shanna. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.
+ Leschek, Ellen W. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States of America.
+ Boden, Matthew G. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.
+ Jadra, Aysha. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.
+ Klibanski, Anne. Division of Pediatric Endocrinology, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, United States of America.
+ Vaidyanathan, Priya. Pediatric Endocrinology, Children's National Medical Center, Washington, DC, United States of America.
+ Misra, Madhusmita. Division of Pediatric Endocrinology, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, United States of America.
+ Chang, Young Pyo. Pediatrics, Dankook University Hospital, Cheonan, Republic of Korea.
+ Yanovski, Jack A. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.
+ Baron, Jeffrey. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ *Biomarkers/bl [Blood]
+ Case-Control Studies
+ Child
+ Child, Preschool
+ Dwarfism/bl [Blood]
+ *Dwarfism/di [Diagnosis]
+ Female
+ Growth Disorders/bl [Blood]
+ *Growth Disorders/di [Diagnosis]
+ Humans
+ Infant
+ Infant, Newborn
+ Male
+ Middle Aged
+ *Midkine/bl [Blood]
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Young Adult
+Abstract
+ BACKGROUND: Midkine (MDK), one of the heparin-binding growth factors, is highly expressed in multiple organs during embryogenesis. Plasma concentrations have been reported to be elevated in patients with a variety of malignancies, in adults with obesity, and in children with short stature, diabetes, and obesity. However, the concentrations in healthy children and their relationships to age, nutrition, and linear growth have not been well studied.
+
+ SUBJECTS AND METHODS: Plasma MDK was measured by immunoassay in 222 healthy, normal-weight children (age 0-18 yrs, 101 boys), 206 healthy adults (age 18-91 yrs, 60 males), 61 children with BMI >= 95th percentile (age 4-18 yrs, 20 boys), 20 girls and young women with anorexia nervosa (age 14-23 yrs), and 75 children with idiopathic short stature (age 3-18 yrs, 42 boys). Body fat was evaluated by dual-energy X-ray absorptiometry (DXA) in a subset of subjects. The associations of MDK with age, sex, adiposity, race/ethnicity and stature were evaluated.
+
+ RESULTS: In healthy children, plasma MDK concentrations declined with age (r = -0.54, P < 0.001) with values highest in infants. The decline occurred primarily during the first year of life. Plasma MDK did not significantly differ between males and females or between race/ethnic groups. MDK concentrations were not correlated with BMI SDS, fat mass (kg) or percent total body fat, and no difference in MDK was found between children with anorexia nervosa, healthy weight and obesity. For children with idiopathic short stature, MDK concentrations did not differ significantly from normal height subjects, or according to height SDS or IGF-1 SDS.
+
+ CONCLUSIONS: In healthy children, plasma MDK concentrations declined with age and were not significantly associated with sex, adiposity, or stature-for-age. These findings provide useful reference data for studies of plasma MDK in children with malignancies and other pathological conditions.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (MDK protein, human). 137497-38-2 (Midkine).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, N.I.H., Intramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0224103
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jee&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Plasma+midkine+concentrations+in+healthy+children%2C+children+with+increased+and+decreased+adiposity%2C+and+children+with+short+stature.&volume=14&issue=10&spage=e0224103&epage=&date=2019&doi=10.1371%2Fjournal.pone.0224103&pmid=31648221&sid=OVID:medline
+
+<1994>
+Unique Identifier
+ 31647300
+Title
+ Comparison of Adiponectin Levels During the Menstrual Cycle Between Normal Weight and Overweight/Obese Young Females.
+Source
+ Physiological Research. 68(6):939-945, 2019 12 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Salem AM; Latif R; Rafique N
+Authors Full Name
+ Salem, A M; Latif, R; Rafique, N.
+Institution
+ Salem, A M. Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. ayadsalem@iau.edu.sa.
+MeSH Subject Headings
+ *Adiponectin/bl [Blood]
+ Adolescent
+ Adult
+ Biomarkers/bl [Blood]
+ Cohort Studies
+ Female
+ Humans
+ *Ideal Body Weight/ph [Physiology]
+ *Menstrual Cycle/bl [Blood]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Overweight/bl [Blood]
+ Overweight/di [Diagnosis]
+ Prospective Studies
+ Young Adult
+Abstract
+ To compare serum adiponectin changes across the menstrual cycle between normal weight and overweight/obese young women and its correlation with serum estradiol. Young women (n=56) with regular menstrual cycle had been grouped according to their BMI into normal weight group (n=26) and overweight /obese group (n=30). Blood samples were drawn during early follicular (FP), pre-ovulatory (OP) and luteal phases (LP) of menstrual cycle for serum adiponectin and estradiol levels determination using enzyme-linked immunosorbent assay. Adiponectin serum level showed a significant decreasing pattern across the phases of menstrual cycle in normal weight group. This pattern was absent in the overweight/obese group. In addition, serum adiponectin was lower in overweight/obese group compared to normal weight subjects through all phases of menstrual cycle. No correlation was found between adiponectin and estradiol levels in both groups. A significant variation of serum adiponectin level was detected across the menstrual cycle in females with normal weight. In comparison, overweight/obese group showed a relatively stable adiponectin level throughout the cycle. This lack of adiponectin variation might be added to the complex mechanisms lies behind obesity-related female infertility.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.33549%2fphysiolres.934197
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Salem&issn=0862-8408&title=Physiological+Research&atitle=Comparison+of+Adiponectin+Levels+During+the+Menstrual+Cycle+Between+Normal+Weight+and+Overweight%2FObese+Young+Females.&volume=68&issue=6&spage=939&epage=945&date=2019&doi=10.33549%2Fphysiolres.934197&pmid=31647300&sid=OVID:medline
+
+<1995>
+Unique Identifier
+ 31640727
+Title
+ Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.
+Source
+ Journal of Translational Medicine. 17(1):348, 2019 10 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Al-Sulaiti H; Diboun I; Agha MV; Mohamed FFS; Atkin S; Domling AS; Elrayess MA; Mazloum NA
+Author NameID
+ Mazloum, Nayef A; ORCID: https://orcid.org/0000-0002-1199-5272
+Authors Full Name
+ Al-Sulaiti, Haya; Diboun, Ilhame; Agha, Maha V; Mohamed, Fatima F S; Atkin, Stephen; Domling, Alex S; Elrayess, Mohamed A; Mazloum, Nayef A.
+Institution
+ Al-Sulaiti, Haya. Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
+ Diboun, Ilhame. Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Doha, Qatar.
+ Agha, Maha V. Weill Cornell Medicine-Qatar, Doha, Qatar.
+ Mohamed, Fatima F S. Weill Cornell Medicine-Qatar, Doha, Qatar.
+ Atkin, Stephen. Weill Cornell Medicine-Qatar, Doha, Qatar.
+ Atkin, Stephen. Royal College of Surgeons, Ireland, Bahrain.
+ Domling, Alex S. Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
+ Elrayess, Mohamed A. Biomedical Research Center (BRC), Qatar University, Doha, Qatar. melrayess@adlqatar.qa.
+ Mazloum, Nayef A. Weill Cornell Medicine-Qatar, Doha, Qatar. nam2016@qatar-med.cornell.edu.
+MeSH Subject Headings
+ Adult
+ Animals
+ Biomarkers/bl [Blood]
+ Diabetes Mellitus, Type 2/bl [Blood]
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Disease Progression
+ Female
+ Humans
+ *Insulin Resistance/ph [Physiology]
+ Male
+ Metabolome
+ Metabolomics
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Phospholipids/bl [Blood]
+ Pilot Projects
+ Translational Research, Biomedical
+ Young Adult
+Keyword Heading
+ Blood metabolites
+ Insulin resistance
+ Insulin sensitivity
+ Metabolomics
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. The underlying metabolic pathways differentiating obese insulin sensitive (OIS) and obese insulin resistant (OIR) individuals remain unclear.
+
+ METHODS: In this study, 107 subjects underwent untargeted metabolomics of serum samples using the Metabolon platform. Thirty-two subjects were lean controls whilst 75 subjects were obese including 20 OIS, 41 OIR, and 14 T2DM individuals.
+
+ RESULTS: Our results showed that phospholipid metabolites including choline, glycerophosphoethanolamine and glycerophosphorylcholine were significantly altered from OIS when compared with OIR and T2DM individuals. Furthermore, our data confirmed changes in metabolic markers of liver disease, vascular disease and T2DM, such as 3-hydroxymyristate, dimethylarginine and 1,5-anhydroglucitol, respectively.
+
+ CONCLUSION: This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. Further studies are warranted to confirm these associations in prospective cohorts and to investigate their functionality.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phospholipids).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12967-019-2096-8
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Al-Sulaiti&issn=1479-5876&title=Journal+of+Translational+Medicine&atitle=Metabolic+signature+of+obesity-associated+insulin+resistance+and+type+2+diabetes.&volume=17&issue=1&spage=348&epage=&date=2019&doi=10.1186%2Fs12967-019-2096-8&pmid=31640727&sid=OVID:medline
+
+<1996>
+Unique Identifier
+ 31640702
+Title
+ Efficacy of visceral fat estimation by dual bioelectrical impedance analysis in detecting cardiovascular risk factors in patients with type 2 diabetes.
+Source
+ Cardiovascular Diabetology. 18(1):137, 2019 10 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Omura-Ohata Y; Son C; Makino H; Koezuka R; Tochiya M; Tamanaha T; Kishimoto I; Hosoda K
+Author NameID
+ Son, Cheol; ORCID: https://orcid.org/0000-0002-7916-0546
+Authors Full Name
+ Omura-Ohata, Yoko; Son, Cheol; Makino, Hisashi; Koezuka, Ryo; Tochiya, Mayu; Tamanaha, Tamiko; Kishimoto, Ichiro; Hosoda, Kiminori.
+Institution
+ Omura-Ohata, Yoko. Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, 6-1 kishibeshin-machi, Suita, Osaka, 564-8565, Japan.
+ Son, Cheol. Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, 6-1 kishibeshin-machi, Suita, Osaka, 564-8565, Japan. son@ncvc.go.jp.
+ Makino, Hisashi. Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, 6-1 kishibeshin-machi, Suita, Osaka, 564-8565, Japan.
+ Koezuka, Ryo. Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, 6-1 kishibeshin-machi, Suita, Osaka, 564-8565, Japan.
+ Tochiya, Mayu. Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, 6-1 kishibeshin-machi, Suita, Osaka, 564-8565, Japan.
+ Tamanaha, Tamiko. Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, 6-1 kishibeshin-machi, Suita, Osaka, 564-8565, Japan.
+ Kishimoto, Ichiro. Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, 6-1 kishibeshin-machi, Suita, Osaka, 564-8565, Japan.
+ Hosoda, Kiminori. Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, 6-1 kishibeshin-machi, Suita, Osaka, 564-8565, Japan.
+MeSH Subject Headings
+ *Adiposity
+ Aged
+ Biomarkers/bl [Blood]
+ Cardiovascular Diseases/di [Diagnosis]
+ *Cardiovascular Diseases/ep [Epidemiology]
+ Comorbidity
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Dyslipidemias/ep [Epidemiology]
+ Electric Impedance
+ Female
+ Humans
+ Hypertension/ep [Epidemiology]
+ Intra-Abdominal Fat/dg [Diagnostic Imaging]
+ *Intra-Abdominal Fat/pp [Physiopathology]
+ Japan/ep [Epidemiology]
+ Male
+ Middle Aged
+ Natriuretic Peptide, Brain/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Predictive Value of Tests
+ Prevalence
+ Reproducibility of Results
+ Risk Factors
+ Tomography, X-Ray Computed
+Keyword Heading
+ Cardiovascular risk factor
+ Impedance
+ Type 2 diabetes
+ Visceral fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Visceral fat area (VFA) is a good surrogate marker of obesity-related disorders, such as hypertension, dyslipidemia and glucose intolerance. Although estimating the VFA by X-ray computed tomography (CT) is the primary index for visceral obesity, it is expensive and requires invasive radiation exposure. Dual bioelectrical impedance analysis (BIA) is a simple and reliable method to estimate VFA; however, the clinical usefulness of dual BIA remains unclear in patients with type 2 diabetes (T2D).
+
+ METHODS: We estimated the VFAs by dual BIA and CT in 98 patients with T2D and assessed anthropometric parameters, blood test results, and the presence of comorbid hypertension and dyslipidemia. We compared the correlation between the VFAs examined by dual BIA and CT. Furthermore, we performed the receiver operating characteristic (ROC) analyses for the VFAs to detect the presence of comorbid hypertension and/or dyslipidemia with T2D, which are major comorbidities of visceral obesity, and estimated the area under the curve (AUC).
+
+ RESULTS: The measurement error between the VFAs by dual BIA and CT was significantly higher among patients with brain natriuretic peptide (BNP) >= 100 pg/mL than those with BNP < 100 pg/mL (39.2% +/- 31.1% vs. 24.1% +/- 18.6%, P < 0.05). After excluding patients with BNP >= 100 pg/mL, the VFA by dual BIA significantly correlated with the VFA by CT (r = 0.917; P < 0.0001). The AUC in the ROC analysis for the VFA by dual BIA to detect the presence of comorbid hypertension and/or dyslipidemia with T2D was almost equivalent to that for the VFA by CT.
+
+ CONCLUSIONS: In patients with T2D without elevated BNP > 100 pg/mL as indicator for fluid accumulation interfering with BIA, estimation of the VFA by dual BIA significantly correlated with that by CT and also detected comorbid hypertension and/or dyslipidemia with T2D equivalent to those detected by CT. Hence, dual BIA could be an alternative to CT as a standard method for estimating the VFA in patients with diabetes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12933-019-0941-y
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Omura-Ohata&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Efficacy+of+visceral+fat+estimation+by+dual+bioelectrical+impedance+analysis+in+detecting+cardiovascular+risk+factors+in+patients+with+type+2+diabetes.&volume=18&issue=1&spage=137&epage=&date=2019&doi=10.1186%2Fs12933-019-0941-y&pmid=31640702&sid=OVID:medline
+
+<1997>
+Unique Identifier
+ 31637623
+Title
+ The Role of Adipose Tissue and Adipokines in Sepsis: Inflammatory and Metabolic Considerations, and the Obesity Paradox. [Review]
+Source
+ Current Obesity Reports. 8(4):434-457, 2019 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Karampela I; Christodoulatos GS; Dalamaga M
+Authors Full Name
+ Karampela, Irene; Christodoulatos, Gerasimos Socrates; Dalamaga, Maria.
+Institution
+ Karampela, Irene. Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini St, Haidari, 12462, Athens, Greece. eikaras1@gmail.com.
+ Karampela, Irene. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527, Athens, Greece. eikaras1@gmail.com.
+ Christodoulatos, Gerasimos Socrates. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527, Athens, Greece.
+ Dalamaga, Maria. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527, Athens, Greece.
+MeSH Subject Headings
+ *Adipokines/me [Metabolism]
+ Adiponectin/me [Metabolism]
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers/bl [Blood]
+ Cytokines/me [Metabolism]
+ Humans
+ Hyperglycemia/co [Complications]
+ Insulin Resistance
+ Leptin/me [Metabolism]
+ Nicotinamide Phosphoribosyltransferase/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Resistin/me [Metabolism]
+ Sepsis/co [Complications]
+ *Sepsis/me [Metabolism]
+ Severity of Illness Index
+Keyword Heading
+ Adipokine
+ Adiponectin
+ Leptin
+ Obesity
+ Resistin
+ Sepsis
+ Visfatin
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: Sepsis has become a global health problem with rising incidence and high mortality, creating a substantial social and economic burden. Early diagnosis and treatment can improve outcome, but reliable sepsis biomarkers are lacking. This review summarizes current evidence of the pathophysiological mechanisms linking adipose tissue to sepsis and presents experimental and clinical data on adipokines and sepsis along with important insights into the obesity paradox in sepsis survival.
+
+ RECENT FINDINGS: Sepsis is characterized by significant alterations in circulating cytokines and adipokines, biologically active molecules produced by the adipose tissue, being implicated in metabolic and inflammatory processes. Although data are inconclusive regarding classic adipokines such as leptin and adiponectin, recent evidence have highlighted the striking elevation of resistin and visfatin in critical illness and sepsis as well as their association with sepsis severity and outcomes. Given that inflammatory and metabolic pathways are involved in sepsis, studying adipokines presents an attractive, innovative, and promising research field that may provide more powerful diagnostic and prognostic biomarkers as well as novel therapeutic targets, empowering the therapeutic armamentarium for sepsis management in order to improve survival.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adipokines). 0 (Adiponectin). 0 (Biomarkers). 0 (Cytokines). 0 (LEP protein, human). 0 (Leptin). 0 (RETN protein, human). 0 (Resistin). EC 2-4-2-12 (Nicotinamide Phosphoribosyltransferase). EC 2-4-2-12 (nicotinamide phosphoribosyltransferase, human).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs13679-019-00360-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Karampela&issn=2162-4968&title=Current+Obesity+Reports&atitle=The+Role+of+Adipose+Tissue+and+Adipokines+in+Sepsis%3A+Inflammatory+and+Metabolic+Considerations%2C+and+the+Obesity+Paradox.&volume=8&issue=4&spage=434&epage=457&date=2019&doi=10.1007%2Fs13679-019-00360-2&pmid=31637623&sid=OVID:medline
+
+<1998>
+Unique Identifier
+ 31636352
+Title
+ The association between metabolic syndrome components and the development of atherosclerosis. [Review]
+Source
+ Journal of Human Hypertension. 33(12):844-855, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aboonabi A; Meyer RR; Singh I
+Author NameID
+ Aboonabi, Anahita; ORCID: http://orcid.org/0000-0001-6213-6673
+Authors Full Name
+ Aboonabi, Anahita; Meyer, Roselyn Rose'; Singh, Indu.
+Institution
+ Aboonabi, Anahita. School of Medical Science, Gold Coast Campus, Griffith University, Parklands Drive, Southport, QLD, 4222, Australia. aa.aboonabi@gmail.com.
+ Meyer, Roselyn Rose'. School of Medical Science, Gold Coast Campus, Griffith University, Parklands Drive, Southport, QLD, 4222, Australia.
+ Singh, Indu. School of Medical Science, Gold Coast Campus, Griffith University, Parklands Drive, Southport, QLD, 4222, Australia.
+MeSH Subject Headings
+ Atherosclerosis/bl [Blood]
+ Atherosclerosis/ep [Epidemiology]
+ Atherosclerosis/pp [Physiopathology]
+ Atherosclerosis/th [Therapy]
+ *Atherosclerosis
+ Biomarkers/bl [Blood]
+ Blood Coagulation
+ Blood Glucose/me [Metabolism]
+ Diet, Atherogenic/ae [Adverse Effects]
+ Disease Progression
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/ep [Epidemiology]
+ Dyslipidemias/pp [Physiopathology]
+ Humans
+ Hyperglycemia/bl [Blood]
+ Hyperglycemia/ep [Epidemiology]
+ Hyperglycemia/pp [Physiopathology]
+ Hypertension/ep [Epidemiology]
+ Hypertension/pp [Physiopathology]
+ Inflammation/bl [Blood]
+ Inflammation/ep [Epidemiology]
+ Inflammation/pp [Physiopathology]
+ Inflammation Mediators/bl [Blood]
+ Insulin Resistance
+ Lipids/bl [Blood]
+ Metabolic Syndrome/bl [Blood]
+ Metabolic Syndrome/ep [Epidemiology]
+ Metabolic Syndrome/pp [Physiopathology]
+ Metabolic Syndrome/th [Therapy]
+ *Metabolic Syndrome
+ Obesity/bl [Blood]
+ Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Oxidative Stress
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Sedentary Behavior
+Abstract
+ Metabolic syndrome (MetS) is a collection of pathological conditions associated with metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the atherosclerotic process with associated clustering of risk factors which can increase the risk of atherogenic damage. There is an association between MetS components and the progression of atherosclerosis, which is the leading cause of cardiovascular deaths. This review was undertaken to assess the potential role of metabolic syndrome components, including oxidative stress, hypertension, hyperglycaemia and insulin resistance, obesity, dyslipidemia, chronic inflammation, physical inactivity, and atherogenic diet in the progression of atherosclerosis based on existing research.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Inflammation Mediators). 0 (Lipids).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41371-019-0273-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aboonabi&issn=0950-9240&title=Journal+of+Human+Hypertension&atitle=The+association+between+metabolic+syndrome+components+and+the+development+of+atherosclerosis.&volume=33&issue=12&spage=844&epage=855&date=2019&doi=10.1038%2Fs41371-019-0273-0&pmid=31636352&sid=OVID:medline
+
+<1999>
+Unique Identifier
+ 31628916
+Title
+ Differential metabolic and inflammatory responses to intermittent hypoxia in substrains of lean and obese C57BL/6 mice.
+Source
+ Life Sciences. 238:116959, 2019 Dec 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ge MQ; Yeung SC; Mak JCW; Ip MSM
+Authors Full Name
+ Ge, Meng Qin; Yeung, Sze Chun; Mak, Judith Choi Wo; Ip, Mary Sau Man.
+Institution
+ Ge, Meng Qin. Departments of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China.
+ Yeung, Sze Chun. Departments of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China.
+ Mak, Judith Choi Wo. Departments of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China; Pharmacology & Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China. Electronic address: judithmak@hku.hk.
+ Ip, Mary Sau Man. Departments of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China. Electronic address: msmip@hku.hk.
+MeSH Subject Headings
+ Adiponectin/me [Metabolism]
+ Animals
+ *Biomarkers/me [Metabolism]
+ Blood Glucose/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ *Hypoxia/co [Complications]
+ *Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ *Inflammation Mediators/me [Metabolism]
+ Insulin Resistance
+ Intra-Abdominal Fat/im [Immunology]
+ *Intra-Abdominal Fat/me [Metabolism]
+ Intra-Abdominal Fat/pa [Pathology]
+ Leptin/me [Metabolism]
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Mice, Obese
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Thinness/et [Etiology]
+ *Thinness/me [Metabolism]
+ Thinness/pa [Pathology]
+ Weight Gain
+Keyword Heading
+ Adipose tissue
+ Intermittent hypoxia (IH)
+ Obesity
+ Obstructive sleep apnea (OSA)
+ genetic background
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: This study was to investigate the degree of susceptibility to intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), between the two mice inbred lines C57BL/6N (6N) and C57BL/6J (6J).
+
+ MATERIALS AND METHODS: Four-week old male mice of 6N and 6J substrains (n=8) were randomized to standard diet (SD) group or high fat (HF) diet group. At the age of 13-week, all two groups of mice were subjected to either air or IH (IH30; thirty hypoxic events per hour) for one week.
+
+ KEY FINDINGS: All mice fed with HF diet exhibited obesity with more body weight and fat mass (percentage to body weight) gain. IH reduced serum LDL, HDL and total cholesterol levels in lean 6J mice. In obese mice, IH lowered obesity-induced serum total cholesterol level in 6J substrain but raised further in 6N substrain. Furthermore, IH caused elevation of serum FFA and MDA levels, and pro-inflammatory cytokines MCP-1 and IL-6 levels in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) of lean 6J but not lean 6N mice. There was reduced number of adipocytes and elevation of macrophages in SAT and VAT of HF-induced obese mice of both substrains. IH led to increased number of adipocytes and macrophages in SAT of lean 6J mice.
+
+ SIGNIFICANCE: The genetic difference between 6N and 6J mice may have direct impact on metabolic and inflammatory responses after IH. Therefore, attention must be given for the selection of C57BL mice substrains in the experimental IH-exposed mouse model. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Adipoq protein, mouse). 0 (Biomarkers). 0 (Blood Glucose). 0 (Inflammation Mediators). 0 (Leptin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.lfs.2019.116959
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ge&issn=0024-3205&title=Life+Sciences&atitle=Differential+metabolic+and+inflammatory+responses+to+intermittent+hypoxia+in+substrains+of+lean+and+obese+C57BL%2F6+mice.&volume=238&issue=&spage=116959&epage=&date=2019&doi=10.1016%2Fj.lfs.2019.116959&pmid=31628916&sid=OVID:medline
+
+<2000>
+Unique Identifier
+ 31626640
+Title
+ Machine learning of human plasma lipidomes for obesity estimation in a large population cohort.
+Source
+ Plos Biology. 17(10):e3000443, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Gerl MJ; Klose C; Surma MA; Fernandez C; Melander O; Mannisto S; Borodulin K; Havulinna AS; Salomaa V; Ikonen E; Cannistraci CV; Simons K
+Author NameID
+ Gerl, Mathias J; ORCID: https://orcid.org/0000-0002-8074-7221
+ Havulinna, Aki S; ORCID: https://orcid.org/0000-0002-4787-8959
+ Salomaa, Veikko; ORCID: https://orcid.org/0000-0001-7563-5324
+Authors Full Name
+ Gerl, Mathias J; Klose, Christian; Surma, Michal A; Fernandez, Celine; Melander, Olle; Mannisto, Satu; Borodulin, Katja; Havulinna, Aki S; Salomaa, Veikko; Ikonen, Elina; Cannistraci, Carlo V; Simons, Kai.
+Institution
+ Gerl, Mathias J. Lipotype GmbH, Dresden, Germany.
+ Klose, Christian. Lipotype GmbH, Dresden, Germany.
+ Surma, Michal A. Lipotype GmbH, Dresden, Germany.
+ Surma, Michal A. Lukasiewicz Research Network-PORT Polish Center for Technology Development, Wroclaw, Poland.
+ Fernandez, Celine. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Melander, Olle. Department of Clinical Sciences, Lund University, Malmo, Sweden.
+ Melander, Olle. Department of Emergency and Internal Medicine, Skane University Hospital, Malmo, Sweden.
+ Mannisto, Satu. Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland.
+ Borodulin, Katja. National Institute for Health and Welfare, Helsinki, Finland.
+ Havulinna, Aki S. National Institute for Health and Welfare, Helsinki, Finland.
+ Havulinna, Aki S. Institute for Molecular Medicine Finland (FIMM-HiLife), Helsinki, Finland.
+ Salomaa, Veikko. National Institute for Health and Welfare, Helsinki, Finland.
+ Ikonen, Elina. Department of Anatomy, Faculty of Medicine, University of Helsinki, Finland.
+ Cannistraci, Carlo V. Biomedical Cybernetics Group, Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Department of Physics, Technische Universitat Dresden, Dresden, Germany.
+ Cannistraci, Carlo V. Center for Systems Biology Dresden, Dresden, Germany.
+ Cannistraci, Carlo V. Complex Network Intelligence Lab, Tsinghua Laboratory of Brain and Intelligence, Tsinghua University, Beijing, China.
+ Simons, Kai. Lipotype GmbH, Dresden, Germany.
+ Simons, Kai. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Biomarkers/bl [Blood]
+ *Body Fat Distribution/sn [Statistics & Numerical Data]
+ Body Mass Index
+ Cohort Studies
+ Female
+ Finland
+ Humans
+ Lipid Metabolism
+ *Lipidomics
+ *Machine Learning
+ Male
+ Models, Statistical
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Sex Factors
+ Sphingomyelins/bl [Blood]
+ Waist Circumference
+ Waist-Hip Ratio
+Abstract
+ Obesity is associated with changes in the plasma lipids. Although simple lipid quantification is routinely used, plasma lipids are rarely investigated at the level of individual molecules. We aimed at predicting different measures of obesity based on the plasma lipidome in a large population cohort using advanced machine learning modeling. A total of 1,061 participants of the FINRISK 2012 population cohort were randomly chosen, and the levels of 183 plasma lipid species were measured in a novel mass spectrometric shotgun approach. Multiple machine intelligence models were trained to predict obesity estimates, i.e., body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and body fat percentage (BFP), and validated in 250 randomly chosen participants of the Malmo Diet and Cancer Cardiovascular Cohort (MDC-CC). Comparison of the different models revealed that the lipidome predicted BFP the best (R2 = 0.73), based on a Lasso model. In this model, the strongest positive and the strongest negative predictor were sphingomyelin molecules, which differ by only 1 double bond, implying the involvement of an unknown desaturase in obesity-related aberrations of lipid metabolism. Moreover, we used this regression to probe the clinically relevant information contained in the plasma lipidome and found that the plasma lipidome also contains information about body fat distribution, because WHR (R2 = 0.65) was predicted more accurately than BMI (R2 = 0.47). These modeling results required full resolution of the lipidome to lipid species level, and the predicting set of biomarkers had to be sufficiently large. The power of the lipidomics association was demonstrated by the finding that the addition of routine clinical laboratory variables, e.g., high-density lipoprotein (HDL)- or low-density lipoprotein (LDL)- cholesterol did not improve the model further. Correlation analyses of the individual lipid species, controlled for age and separated by sex, underscores the multiparametric and lipid species-specific nature of the correlation with the BFP. Lipidomic measurements in combination with machine intelligence modeling contain rich information about body fat amount and distribution beyond traditional clinical assays.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Sphingomyelins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pbio.3000443
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Gerl&issn=1544-9173&title=Plos+Biology&atitle=Machine+learning+of+human+plasma+lipidomes+for+obesity+estimation+in+a+large+population+cohort.&volume=17&issue=10&spage=e3000443&epage=&date=2019&doi=10.1371%2Fjournal.pbio.3000443&pmid=31626640&sid=OVID:medline
+
+<2001>
+Unique Identifier
+ 31623319
+Title
+ A Proteomics-Based Approach Reveals Differential Regulation of Urine Proteins between Metabolically Healthy and Unhealthy Obese Patients.
+Source
+ International Journal of Molecular Sciences. 20(19), 2019 Oct 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Benabdelkamel H; Masood A; Okla M; Al-Naami MY; Alfadda AA
+Author NameID
+ Masood, Afshan; ORCID: https://orcid.org/0000-0001-8082-9326
+ Alfadda, Assim A; ORCID: https://orcid.org/0000-0002-4792-5188
+Authors Full Name
+ Benabdelkamel, Hicham; Masood, Afshan; Okla, Meshail; Al-Naami, Mohammed Y; Alfadda, Assim A.
+Institution
+ Benabdelkamel, Hicham. Proteomics Resource Unit Obesity, Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. hbenabdelkamel@ksu.edu.sa.
+ Masood, Afshan. Proteomics Resource Unit Obesity, Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. afsmasood@ksu.edu.sa.
+ Okla, Meshail. Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, 183T11, Riyadh 11495, Saudi Arabia. meokla@ksu.edu.sa.
+ Al-Naami, Mohammed Y. Department of Surgery, College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia. alnaami@ksu.edu.sa.
+ Alfadda, Assim A. Proteomics Resource Unit Obesity, Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. aalfadda@ksu.edu.sa.
+ Alfadda, Assim A. Department of Medicine, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. aalfadda@ksu.edu.sa.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Female
+ Health Status
+ Humans
+ Male
+ Obesity/co [Complications]
+ *Obesity/ur [Urine]
+ Protein Interaction Mapping
+ Proteinuria/et [Etiology]
+ *Proteinuria/ur [Urine]
+ *Proteome
+ Proteomics/mt [Methods]
+ *Proteomics
+Keyword Heading
+ healthy obese
+ metabolic syndrome
+ obesity
+ proteomics
+ unhealthy obese
+ urine proteins
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Metabolic dysfunction associated with obesity threatens to inundate health care resources by increasing the incidences of obesity-related diseases. The aim of the present study was to investigate the changes in the urinary proteome of 18 individuals classified into metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) patients. Proteome analysis was performed using the two-dimensional difference in gel electrophoresis (2D-DIGE) coupled with mass spectrometry (MS). Upon analysis, a total of 54 proteins were found to be affected with >=1.5-fold change (ANOVA, p <= 0.05), of which 44 proteins were upregulated and 10 proteins were downregulated. These differentially abundant proteins were related to nuclear factor kappaB (NF-kappaB) and p38 mitogen-activated protein (MAP) kinase pathways and were involved in cellular compromise, inflammatory response, and cancer. Proteins involved in inflammation (fibrinogen alpha (FIBA), serotransferrin (TRFE, and kininogen-1 (KNG1)) and insulin resistance (ADP-ribosylation factor (ARF)-like protein 15 (ARL15) and retinol-binding protein 4 (RET4)) were found to be significantly increased in the urine samples of MUHO compared to MHO patients. Investigating the effects of obesity on urinary proteins can help in developing efficient diagnostic procedures for early detection and prevention of obesity-related complications.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteome).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20194905
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Benabdelkamel&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=A+Proteomics-Based+Approach+Reveals+Differential+Regulation+of+Urine+Proteins+between+Metabolically+Healthy+and+Unhealthy+Obese+Patients.&volume=20&issue=19&spage=4905&epage=&date=2019&doi=10.3390%2Fijms20194905&pmid=31623319&sid=OVID:medline
+
+<2002>
+Unique Identifier
+ 31619235
+Title
+ Association of adiposity with thyroid nodules: a cross-sectional study of a healthy population in Beijing, China.
+Source
+ BMC Endocrine Disorders. 19(1):102, 2019 Oct 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yang HX; Zhong Y; Lv WH; Zhang F; Yu H
+Authors Full Name
+ Yang, Hui-Xia; Zhong, Yu; Lv, Wei-Hua; Zhang, Feng; Yu, Hong.
+Institution
+ Yang, Hui-Xia. Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu, Shijingshan District, Beijing, 100144, China.
+ Zhong, Yu. Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu, Shijingshan District, Beijing, 100144, China.
+ Lv, Wei-Hua. Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu, Shijingshan District, Beijing, 100144, China.
+ Zhang, Feng. Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu, Shijingshan District, Beijing, 100144, China.
+ Yu, Hong. Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu, Shijingshan District, Beijing, 100144, China. y_hong@aliyun.com.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ *Intra-Abdominal Fat
+ Male
+ Middle Aged
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Risk Factors
+ *Thyroid Nodule/ep [Epidemiology]
+Keyword Heading
+ Adiposity
+ Body mass index
+ Thyroid nodules
+ Visceral fat area
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The relationship between thyroid nodules (TNs) and adiposity is controversial. This paper describes a cross-sectional investigation performed to determine the existence of any such relationship. To assess adiposity, body mass index (BMI) and visceral fat area (VFA) were utilized.
+
+ METHODS: Between January 1, 2017 and March 3, 2019. Three thousand five hundred thirty four healthy people were examined using thyroid ultrasonography, visceral fat and anthropometric measurements, laboratory tests and questionnaire interview. Binary logistic regression analyses were used.
+
+ RESULTS: Of the 3534 healthy subjects, 58.69% (2074/3534) of the subjects had TNs. A total of 55.91% (1976/3534) had BMI >= 25 kg/m2 and 39.67% (1402/3534) had VFA >= 100 cm2. After adjustment to address confounders, BMI-based overweight and obesity levels only correlated with higher risk TNs when used as a continuous variable (OR = 1.031, 95% CI: 1.008-1.055, P = 0.008), while VFA was both a continuous variable (OR = 1.003, 95% CI: 1.000-1.005, P = 0.034) and a categorical variable (OR = 1.198, 95% CI: 1.014-1.417, P = 0.034) associated with significantly elevated risk of TNs. Analyzing the subgroups, BMI >= 25 kg/m2 (OR = 1.500, 95% CI: 1.110-2.026, P = 0.008) was significantly correlated with TN risk in individuals with TG >= 1.7 mmol/L. VFA >= 100 cm2 correlated with the TN risk irrespective of age (< 50 years: OR = 1.374, 95% CI: 1.109-1.703, P = 0.004; >= 50 years: OR = 1.367, 95% CI: 1.063-1.759, P = 0.015) and in the following subgroups: women (OR = 4.575, 95% CI: 2.558-8.181, P = 0.000), FBG >= 6.1 mmol/L (OR = 1.522, 95% CI: 1.048-2.209, P = 0.027), and TG >= 1.7 mmol/L (OR = 1.414, 95% CI: 1.088-1.838, P = 0.010).
+
+ CONCLUSIONS: Adiposity correlates with TNs. To assess TN risk in Chinese individuals, VFA is better than BMI.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0430-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yang&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Association+of+adiposity+with+thyroid+nodules%3A+a+cross-sectional+study+of+a+healthy+population+in+Beijing%2C+China.&volume=19&issue=1&spage=102&epage=&date=2019&doi=10.1186%2Fs12902-019-0430-z&pmid=31619235&sid=OVID:medline
+
+<2003>
+Unique Identifier
+ 31619003
+Title
+ Effects of a Flavonoid-Rich Extract from Citrus sinensis Juice on a Diet-Induced Obese Zebrafish.
+Source
+ International Journal of Molecular Sciences. 20(20), 2019 Oct 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Montalbano G; Mania M; Guerrera MC; Laura R; Abbate F; Levanti M; Maugeri A; Germana A; Navarra M
+Author NameID
+ Mania, Manuela; ORCID: https://orcid.org/0000-0001-5144-8719
+ Navarra, Michele; ORCID: https://orcid.org/0000-0002-6492-7820
+Authors Full Name
+ Montalbano, Giuseppe; Mania, Manuela; Guerrera, Maria Cristina; Laura, Rosaria; Abbate, Francesco; Levanti, Maria; Maugeri, Alessandro; Germana, Antonino; Navarra, Michele.
+Institution
+ Montalbano, Giuseppe. Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98122 Messina, Italy. gmontalbano@unime.it.
+ Mania, Manuela. Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98122 Messina, Italy. manuela.mania87@gmail.com.
+ Guerrera, Maria Cristina. Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98122 Messina, Italy. mcguerrera@unime.it.
+ Laura, Rosaria. Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98122 Messina, Italy. laurar@unime.it.
+ Abbate, Francesco. Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98122 Messina, Italy. abbatef@unime.it.
+ Levanti, Maria. Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98122 Messina, Italy. mblevanti@unime.it.
+ Maugeri, Alessandro. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98122 Messina, Italy. amaugeri@unime.it.
+ Germana, Antonino. Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98122 Messina, Italy. agermana@unime.it.
+ Navarra, Michele. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98122 Messina, Italy. mnavarra@unime.it.
+MeSH Subject Headings
+ Adipocytes/me [Metabolism]
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ Body Weight
+ *Citrus sinensis/ch [Chemistry]
+ *Diet/ae [Adverse Effects]
+ Flavonoids/ch [Chemistry]
+ *Flavonoids/pd [Pharmacology]
+ *Fruit and Vegetable Juices
+ Gene Expression Profiling
+ Immunohistochemistry
+ Lipolysis
+ *Obesity/dt [Drug Therapy]
+ *Obesity/et [Etiology]
+ Obesity/pa [Pathology]
+ Plant Extracts/ch [Chemistry]
+ *Plant Extracts/pd [Pharmacology]
+ Zebrafish
+Keyword Heading
+ Citrus sinensis
+ diet-induced obesity
+ flavonoids
+ lipolysis
+ orange juice
+ zebrafish
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity is a pathological condition that has reached epidemic proportions; hence, it is necessary to find novel strategies aimed at fighting this disease. The present study was designed to evaluate the effect of a flavonoid-rich extract of orange (Citrus sinensis) juice (OJe) in diet-induced obese zebrafish.
+
+ METHODS: Adult zebrafish were divided into four diet groups: (i) normally fed (NF); (ii) overfed (OF); (iii) NF supplemented with OJe (5 mL/L in fish water; NF + OJe); and (iv) OF supplemented with OJe (OF + OJe). Each week, body weight (BW) and body mass index (BMI) were measured, and, at the end of the fifth week, euthanized zebrafish were processed for both microscopic evaluations and qPCR analyses.
+
+ RESULTS: In OF zebrafish, OJe significantly decreased both BW and BMI values and lowered the visceral adipose tissue, while it had little effect in the NF group. Moreover, it significantly reduced adipocyte cell size in both NF and OF groups in both visceral and subcutaneous adipose tissues, as well as their number in OF fish. Finally, OJe modulated some obesity-related genes, such as leptin A, ghrelin, orexin, pro-opiomelanocortin (POMC), and neuropeptide Y (NPY), in both gut and brain.
+
+ CONCLUSION: This study adds new insights into the anti-obesity properties of orange juice and its flavonoids, suggesting their role as weight management agents through a lipolytic action linked to a restoration of metabolism-regulating gene expression.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Flavonoids). 0 (Plant Extracts).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20205116
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Montalbano&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Effects+of+a+Flavonoid-Rich+Extract+from+Citrus+sinensis+Juice+on+a+Diet-Induced+Obese+Zebrafish.&volume=20&issue=20&spage=5116&epage=&date=2019&doi=10.3390%2Fijms20205116&pmid=31619003&sid=OVID:medline
+
+<2004>
+Unique Identifier
+ 31618980
+Title
+ Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1.
+Source
+ Nutrients. 11(10), 2019 Oct 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lee HS; Lim SM; Jung JI; Kim SM; Lee JK; Kim YH; Cha KM; Oh TK; Moon JM; Kim TY; Kim EJ
+Author NameID
+ Lee, Hyun Sook; ORCID: https://orcid.org/0000-0002-8642-1978
+ Kim, Eun Ji; ORCID: https://orcid.org/0000-0001-9305-4769
+Authors Full Name
+ Lee, Hyun Sook; Lim, Su-Min; Jung, Jae In; Kim, So Mi; Lee, Jae Kyoung; Kim, Yoon Hee; Cha, Kyu Min; Oh, Tae Kyu; Moon, Joo Myung; Kim, Tae Young; Kim, Eun Ji.
+Institution
+ Lee, Hyun Sook. Department of Food Science & Nutrition, Dongseo University, Busan 47011, Korea. hyunlee@dongseo.ac.kr.
+ Lim, Su-Min. Regional Strategic Industry Innovation Center, Hallym University, Chuncheon 24252, Korea. sumin8481@hallym.ac.kr.
+ Jung, Jae In. Regional Strategic Industry Innovation Center, Hallym University, Chuncheon 24252, Korea. jungahoo@hallym.ac.kr.
+ Kim, So Mi. Regional Strategic Industry Innovation Center, Hallym University, Chuncheon 24252, Korea. somisss@hallym.ac.kr.
+ Lee, Jae Kyoung. Technology Development Center, BTC Corporation, Ansan 15588, Korea. ljk@btcbio.com.
+ Kim, Yoon Hee. Technology Development Center, BTC Corporation, Ansan 15588, Korea. kyh@btcbio.com.
+ Cha, Kyu Min. Technology Development Center, BTC Corporation, Ansan 15588, Korea. ckm@btcbio.com.
+ Oh, Tae Kyu. Technology Development Center, BTC Corporation, Ansan 15588, Korea. otk@btcbio.com.
+ Moon, Joo Myung. Technology Development Center, BTC Corporation, Ansan 15588, Korea. mhjj1919@btcbio.com.
+ Kim, Tae Young. Technology Development Center, BTC Corporation, Ansan 15588, Korea. tykim@btcbio.com.
+ Kim, Eun Ji. Regional Strategic Industry Innovation Center, Hallym University, Chuncheon 24252, Korea. myej4@hallym.ac.kr.
+MeSH Subject Headings
+ AMP-Activated Protein Kinases/me [Metabolism]
+ *Adipogenesis/de [Drug Effects]
+ *Adipose Tissue, White/de [Drug Effects]
+ Adipose Tissue, White/en [Enzymology]
+ Adipose Tissue, White/pp [Physiopathology]
+ Adiposity/de [Drug Effects]
+ Animals
+ Anti-Obesity Agents/ip [Isolation & Purification]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Blood Glucose/de [Drug Effects]
+ Blood Glucose/me [Metabolism]
+ *Diet, High-Fat
+ Disease Models, Animal
+ *Gynostemma/ch [Chemistry]
+ Lipids/bl [Blood]
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ Obesity/en [Enzymology]
+ Obesity/pp [Physiopathology]
+ *Obesity/pc [Prevention & Control]
+ Oxidation-Reduction
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ Signal Transduction
+ *Sirtuin 1/me [Metabolism]
+ Up-Regulation
+ Weight Gain/de [Drug Effects]
+Keyword Heading
+ AMPK
+ Gynostemma pentaphyllum
+ SIRT1
+ ginsenoside
+ gypenoside
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Gynostemma pentaphyllum is widely used in Asia as a herbal medicine to treat type 2 diabetes, dyslipidemia, and inflammation. Here, we investigated the anti-obesity effect and underlying mechanism of G. pentaphyllum extract (GPE) enriched in gypenoside L, gypenoside LI, and ginsenoside Rg3 and obtained using a novel extraction method. Five-week-old male C57BL/6N mice were fed a control diet (CD), high-fat diet (HFD), HFD + 100 mg/kg body weight (BW)/day GPE (GPE 100), HFD + 300 mg/kg BW/day GPE (GPE 300), or HFD + 30 mg/kg BW/day Orlistat (Orlistat 30) for 8 weeks. The HFD-fed mice showed significant increases in body weight, fat mass, white adipose tissue, and adipocyte hypertrophy compared to the CD group; but GPE inhibited those increases. GPE reduced serum levels of triglyceride, total cholesterol, and LDL-cholesterol, without affecting HDL-cholesterol. GPE significantly increased AMPK activation and suppressed adipogenesis by decreasing the mRNA expression of CCAAT/enhancer binding protein-alpha (C/EBPalpha), peroxisome proliferator-activated receptor-gamma (PPARgamma), sterol regulatory element-binding protein-1c (SREBP1c), PPARgamma coactivator-1alpha, fatty acid synthase (FAS), adipocyte protein 2 (AP2), and sirtuin 1 (SIRT1) and by increasing that of carnitine palmitoyltransferase (CPT1) and hormone- sensitive lipase (HSL). This study demonstrated the ameliorative effect of GPE on obesity and elucidated the underlying molecular mechanism.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Blood Glucose). 0 (Lipids). 0 (Plant Extracts). EC 2-7-11-31 (AMP-Activated Protein Kinases). EC 3-5-1 (Sirt1 protein, mouse). EC 3-5-1 (Sirtuin 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11102475
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lee&issn=2072-6643&title=Nutrients&atitle=Gynostemma+Pentaphyllum+Extract+Ameliorates+High-Fat+Diet-Induced+Obesity+in+C57BL%2F6N+Mice+by+Upregulating+SIRT1.&volume=11&issue=10&spage=&epage=&date=2019&doi=10.3390%2Fnu11102475&pmid=31618980&sid=OVID:medline
+
+<2005>
+Unique Identifier
+ 31615559
+Title
+ Prostatic-specific antigen (PSA) levels in patients with polycystic ovary syndrome (PCOS): a meta-analysis. [Review]
+Source
+ Journal of ovarian research. 12(1):94, 2019 Oct 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Wu ZH; Tang Y; Niu X; Pu FF; Xiao XY; Kong W
+Author NameID
+ Xiao, Xi-Yue; ORCID: http://orcid.org/0000-0002-3968-6535
+Authors Full Name
+ Wu, Zeng-Hong; Tang, Yun; Niu, Xun; Pu, Fei-Fei; Xiao, Xi-Yue; Kong, Wen.
+Institution
+ Wu, Zeng-Hong. Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
+ Wu, Zeng-Hong. Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
+ Tang, Yun. Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
+ Niu, Xun. Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
+ Pu, Fei-Fei. Department of Orthopedics, Wuhan No.1 Hospital, Wuhan Integrated TCM & Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People's Republic of China.
+ Xiao, Xi-Yue. Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 425643478@qq.com.
+ Kong, Wen. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. wenly-kong@163.com.
+MeSH Subject Headings
+ Anovulation/bl [Blood]
+ Anovulation/pa [Pathology]
+ *Biomarkers/bl [Blood]
+ Female
+ Humans
+ Hyperandrogenism/bl [Blood]
+ Hyperandrogenism/pa [Pathology]
+ Hyperinsulinism/bl [Blood]
+ Hyperinsulinism/pa [Pathology]
+ Menstruation Disturbances/bl [Blood]
+ Menstruation Disturbances/pa [Pathology]
+ Obesity/bl [Blood]
+ Obesity/pa [Pathology]
+ *Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/ep [Epidemiology]
+ Polycystic Ovary Syndrome/pa [Pathology]
+ *Prostate-Specific Antigen/bl [Blood]
+Keyword Heading
+ Meta-analysis
+ PCOS
+ Prostatic-specific antigen
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ PURPOSE: The polycystic ovary syndrome (PCOS) is a reproductive endocrine disorder, clinically characterized by oligo-ovulation/chronic anovulation, menstrual irregularities, hyperandrogenism (such as hirsutism, acne), hyperinsulinemia, and obesity. Prostatic-specific antigen (PSA) has been identified as a potential new marker in PCOS women. Although the precise role of PSA in PCOS patients still remains undetermined, PSA might serve as a useful clinical marker and might even represent a new diagnostic criterion of hyperandrogenemia in females of PCOS.
+
+ METHODS: A meta-analysis was performed in the study to identify the association between the polycystic ovary syndrome and prostatic-specific antigen. To identify eligible original articles, we searched a range of computerized databases, including Medline via PubMed, EMBASE, CNKI and Web of Science with a systematic searching strategy. The characteristics of each study and standard mean differences (SMD) with corresponding confidence intervals (CIs) were calculated and subgroup analysis was performed to analyze heterogeneity.
+
+ RESULTS: A total of 532 patients from seven articles were included in the meta-analysis. We identified a significant relationship between polycystic ovary syndrome and prostatic-specific antigen, with a pooled SMD of 0.81 (95% CI: 0.58 to 1.04; P < 0.01). The pooled data were calculated with the random-effects model as a moderate significant heterogeneity was found among the studies.
+
+ CONCLUSIONS: The meta-analysis suggested that there was a significant association between the polycystic ovary syndrome and prostatic-specific antigen and we should not ignore the role of PSA in the PCOS patients in clinical.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 3-4-21-77 (Prostate-Specific Antigen).
+Publication Type
+ Journal Article. Meta-Analysis. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs13048-019-0569-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Wu&issn=1757-2215&title=Journal+of+ovarian+research&atitle=Prostatic-specific+antigen+%28PSA%29+levels+in+patients+with+polycystic+ovary+syndrome+%28PCOS%29%3A+a+meta-analysis.&volume=12&issue=1&spage=94&epage=&date=2019&doi=10.1186%2Fs13048-019-0569-2&pmid=31615559&sid=OVID:medline
+
+<2006>
+Unique Identifier
+ 31601214
+Title
+ Maternal cardiometabolic markers are associated with fetal growth: a secondary exploratory analysis of the LIMIT randomised trial.
+Source
+ BMC Endocrine Disorders. 19(1):97, 2019 Oct 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ O'Brien CM; Louise J; Deussen A; Dodd JM
+Author NameID
+ O'Brien, Cecelia M; ORCID: http://orcid.org/0000-0001-5299-7197
+Authors Full Name
+ O'Brien, Cecelia M; Louise, Jennie; Deussen, Andrea; Dodd, Jodie M.
+Institution
+ O'Brien, Cecelia M. School of Paediatrics and Reproductive Health, and Robinson Research Institute, University of Adelaide, Adelaide, Australia. cecelia.obrien@adelaide.edu.au.
+ O'Brien, Cecelia M. Women's and Children's Hospital, The University of Adelaide, 72 King William Road, North Adelaide, SA, 5006, Australia. cecelia.obrien@adelaide.edu.au.
+ Louise, Jennie. School of Paediatrics and Reproductive Health, and Robinson Research Institute, University of Adelaide, Adelaide, Australia.
+ Louise, Jennie. School of Public Health, University of Adelaide, Adelaide, Australia.
+ Deussen, Andrea. School of Paediatrics and Reproductive Health, and Robinson Research Institute, University of Adelaide, Adelaide, Australia.
+ Dodd, Jodie M. School of Paediatrics and Reproductive Health, and Robinson Research Institute, University of Adelaide, Adelaide, Australia.
+ Dodd, Jodie M. Department of Perinatal Medicine, Women's and Babies Division, Women's and Children's Hospital, Adelaide, Australia.
+MeSH Subject Headings
+ Adiponectin/me [Metabolism]
+ *Adiposity
+ Adult
+ *Biomarkers/me [Metabolism]
+ *Cardiovascular Diseases/di [Diagnosis]
+ Cardiovascular Diseases/ep [Epidemiology]
+ Cardiovascular Diseases/me [Metabolism]
+ Female
+ *Fetal Development
+ Fetal Weight
+ Follow-Up Studies
+ Gestational Age
+ Humans
+ *Inflammation/di [Diagnosis]
+ Inflammation/ep [Epidemiology]
+ Inflammation/me [Metabolism]
+ *Inflammation Mediators/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Overweight/pp [Physiopathology]
+ Prognosis
+Keyword Heading
+ Adiponectin
+ Cardiometabolic markers
+ Fetal body composition
+ Obesity
+ Pregnancy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: To determine the association between maternal cardiometabolic and inflammatory markers with measures of fetal biometry and adiposity.
+
+ METHODS: Women included in this exploratory analysis were randomised to the 'Standard Care' group (N = 911) from the LIMIT randomised trial involving a total of 2212 pregnant women who were overweight or obese (ACTRN12607000161426, Date of registration 9/03/2007, prospectively registered). Fetal biometry including abdominal circumference (AC), estimated fetal weight (EFW), and adiposity measurements (mid-thigh fat mass, subscapular fat mass, abdominal fat mass) were obtained from ultrasound assessments at 28 and 36 weeks' gestation. Maternal markers included C reactive protein (CRP), leptin and adiponectin concentrations, measured at 28 and 36 weeks' gestation and fasting triglycerides and glucose concentrations measured at 28 weeks' gestation.
+
+ RESULTS: There were negative associations identified between maternal serum adiponectin and fetal ultrasound markers of biometry and adiposity. After adjusting for confounders, a 1-unit increase in log Adiponectin was associated with a reduction in the mean AC z score [- 0.21 (- 0.35, - 0.07), P = 0.004] and EFW [- 0.23 (- 0.37, - 0.10), P < 0.001] at 28 weeks gestation. Similarly, a 1-unit increase in log Adiponectin was association with a reduction in the mean AC z score [- 0.30 (- 0.46, - 0.13), P < 0.001] and EFW [- 0.24 (- 0.38, - 0.10), P < 0.001] at 36 weeks gestation. There were no consistent associations between maternal cardiometabolic and inflammatory markers with measurements of fetal adiposity.
+
+ CONCLUSION: Adiponectin concentrations are associated with measures of fetal growth. Our findings contribute to further understanding of fetal growth in the setting of women who are overweight or obesity.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0416-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=O%27Brien&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=Maternal+cardiometabolic+markers+are+associated+with+fetal+growth%3A+a+secondary+exploratory+analysis+of+the+LIMIT+randomised+trial.&volume=19&issue=1&spage=97&epage=&date=2019&doi=10.1186%2Fs12902-019-0416-x&pmid=31601214&sid=OVID:medline
+
+<2007>
+Unique Identifier
+ 31600210
+Title
+ Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance.
+Source
+ PLoS ONE [Electronic Resource]. 14(10):e0222278, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yuzefovych LV; Pastukh VM; Ruchko MV; Simmons JD; Richards WO; Rachek LI
+Authors Full Name
+ Yuzefovych, Larysa V; Pastukh, Viktor M; Ruchko, Mykhaylo V; Simmons, Jon D; Richards, William O; Rachek, Lyudmila I.
+Institution
+ Yuzefovych, Larysa V. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, United States of America.
+ Pastukh, Viktor M. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, United States of America.
+ Ruchko, Mykhaylo V. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, United States of America.
+ Simmons, Jon D. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, United States of America.
+ Simmons, Jon D. Department of Surgery, College of Medicine, University of South Alabama, Mobile, Alabama, United States of America.
+ Richards, William O. Department of Surgery, College of Medicine, University of South Alabama, Mobile, Alabama, United States of America.
+ Rachek, Lyudmila I. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, United States of America.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Biopsy
+ Blood Glucose/ge [Genetics]
+ *DNA, Mitochondrial/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/co [Complications]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ Female
+ Humans
+ *Insulin Resistance/ge [Genetics]
+ Male
+ Muscle, Skeletal/me [Metabolism]
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ Obesity/pa [Pathology]
+ Oxidative Stress/ge [Genetics]
+Abstract
+ Cells damaged by mechanical or infectious injury release proinflammatory mitochondrial DNA (mtDNA) fragments into the circulation. We evaluated the relation between plasma levels of mtDNA fragments in obese type 2 diabetes mellitus (T2DM) patients and measures of chronic inflammation and insulin resistance. In 10 obese T2DM patients and 12 healthy control (HC) subjects, we measured levels of plasma cell-free mtDNA with quantitative real-time polymerase chain reaction, and mtDNA damage in skeletal muscle with quantitative alkaline Southern blot. Also, markers of systemic inflammation and oxidative stress in skeletal muscle were measured. Plasma levels of mtDNA fragments, mtDNA damage in skeletal muscle and plasma tumor necrosis factor alpha levels were greater in obese T2DM patients than HC subjects. Also, the abundance of plasma mtDNA fragments in obese T2DM patients levels positively correlated with insulin resistance. To the best of our knowledge, this is the first published evidence that elevated level of plasma mtDNA fragments is associated with mtDNA damage and oxidative stress in skeletal muscle and correlates with insulin resistance in obese T2DM patients. Plasma mtDNA may be a useful biomarker for predicting and monitoring insulin resistance in obese patients.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (DNA, Mitochondrial).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0222278
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yuzefovych&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Plasma+mitochondrial+DNA+is+elevated+in+obese+type+2+diabetes+mellitus+patients+and+correlates+positively+with+insulin+resistance.&volume=14&issue=10&spage=e0222278&epage=&date=2019&doi=10.1371%2Fjournal.pone.0222278&pmid=31600210&sid=OVID:medline
+
+<2008>
+Unique Identifier
+ 31599289
+Title
+ Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy.
+Source
+ Molecular Omics. 15(6):420-430, 2019 12 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Furse S; White SL; Meek CL; Jenkins B; Petry CJ; Vieira MC; Ozanne SE; Dunger DB; Poston L; Koulman A
+Authors Full Name
+ Furse, Samuel; White, Sara L; Meek, Claire L; Jenkins, Benjamin; Petry, Clive J; Vieira, Matias C; Ozanne, Susan E; Dunger, David B; Poston, Lucilla; Koulman, Albert.
+Institution
+ Furse, Samuel. Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Box 289, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, UK. sf615@cam.ac.uk samuel@samuelfurse.com.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Biomarkers
+ *Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/et [Etiology]
+ *Diabetes, Gestational/me [Metabolism]
+ Female
+ Humans
+ Infant, Newborn
+ *Lipid Metabolism
+ Male
+ Metabolomics/mt [Methods]
+ Middle Aged
+ *Obesity/co [Complications]
+ Odds Ratio
+ Phospholipids/bl [Blood]
+ *Phospholipids/me [Metabolism]
+ Pregnancy
+ Prognosis
+ Triglycerides/bl [Blood]
+ *Triglycerides/me [Metabolism]
+ Young Adult
+Abstract
+ Gestational diabetes (GDM), a common pregnancy complication associated with obesity and long-term health risks, is usually diagnosed at approximately 28 weeks of gestation. An understanding of lipid metabolism in women at risk of GDM could contribute to earlier diagnosis and treatment. We tested the hypothesis that altered lipid metabolism at the beginning of the second trimester in obese pregnant women is associated with a diagnosis of GDM. Plasma samples from 831 participants (16-45 years, 15-18 weeks gestation, BMI >= 30) from the UPBEAT study of obese pregnant women were used. The lipid, sterol and glyceride fraction was isolated and analysed in a semi-quantitative fashion using direct infusion mass spectrometry. A combination of uni-, multi-variate and multi-variable statistical analyses was used to identify candidate biomarkers in plasma associated with a diagnosis of GDM (early third trimester; IADPSG criteria). Multivariable adjusted analyses showed that participants who later developed GDM had a greater abundance of several triglycerides (48:0, 50:1, 50:2, 51:5, 53:4) and phosphatidylcholine (38:5). In contrast sphingomyelins (32:1, 41:2, 42:3), lyso-phosphatidylcholine (16:0, 18:1), phosphatidylcholines (35:2, 40:7, 40:10), two polyunsaturated triglycerides (46:5, 48:6) and several oxidised triglycerides (48:6, 54:4, 56:4, 58:6) were less abundant. We concluded that both lipid and triglyceride metabolism were altered at least 10 weeks before diagnosis of GDM. Further investigation is required to determine the functional consequences of these differences and the mechanisms by which they arise.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Phospholipids). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1039%2fc9mo00117d
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Furse&issn=2515-4184&title=Molecular+Omics&atitle=Altered+triglyceride+and+phospholipid+metabolism+predates+the+diagnosis+of+gestational+diabetes+in+obese+pregnancy.&volume=15&issue=6&spage=420&epage=430&date=2019&doi=10.1039%2Fc9mo00117d&pmid=31599289&sid=OVID:medline
+
+<2009>
+Unique Identifier
+ 31590286
+Title
+ Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity.
+Source
+ Nutrients. 11(10), 2019 Oct 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Sajoux I; Lorenzo PM; Gomez-Arbelaez D; Zulet MA; Abete I; Castro AI; Baltar J; Portillo MP; Tinahones FJ; Martinez JA; Crujeiras AB; Casanueva FF
+Authors Full Name
+ Sajoux, Ignacio; Lorenzo, Paula M; Gomez-Arbelaez, Diego; Zulet, M Angeles; Abete, Itziar; Castro, Ana I; Baltar, Javier; Portillo, Maria P; Tinahones, Francisco J; Martinez, J Alfredo; Crujeiras, Ana B; Casanueva, Felipe F.
+Institution
+ Sajoux, Ignacio. Division of Endocrinology, Department of Medicine, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Instituto de Investigacion Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, Spain. ignacio.s@pronokal.com.
+ Sajoux, Ignacio. Medical Department Pronokal, Protein Supplies SL, Barcelona 08009, Spain. ignacio.s@pronokal.com.
+ Lorenzo, Paula M. Division of Endocrinology, Department of Medicine, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Instituto de Investigacion Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, Spain. pmarino@alumni.unav.es.
+ Gomez-Arbelaez, Diego. Division of Endocrinology, Department of Medicine, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Instituto de Investigacion Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, Spain. diedgomez@gmail.com.
+ Gomez-Arbelaez, Diego. Faculty of Health Sciences, University of Santander (UDES), 680003 Bucaramanga, Colombia. diedgomez@gmail.com.
+ Zulet, M Angeles. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra (UNAV) and IdiSNA, Navarra Institute for Health Research, 31009 Pamplona, Spain. mazulet@unav.es.
+ Zulet, M Angeles. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. mazulet@unav.es.
+ Abete, Itziar. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra (UNAV) and IdiSNA, Navarra Institute for Health Research, 31009 Pamplona, Spain. iabetego@unav.es.
+ Abete, Itziar. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. iabetego@unav.es.
+ Castro, Ana I. Division of Endocrinology, Department of Medicine, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Instituto de Investigacion Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, Spain. anaisabel0102@gmail.com.
+ Castro, Ana I. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. anaisabel0102@gmail.com.
+ Baltar, Javier. Division of General Surgery, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. javier.baltar.boileve@sergas.es.
+ Portillo, Maria P. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. mariapuy.portillo@ehu.eus.
+ Portillo, Maria P. Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 01005 Vitoria, Spain. mariapuy.portillo@ehu.eus.
+ Tinahones, Francisco J. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. javier.baltar.boileve@sergas.es.
+ Tinahones, Francisco J. Unidad de Gestion Clinica de Endocrinologia y Nutricion, Instituto de Investigacion Biomedica de Malaga (IBIMA), Complejo Hospitalario de Malaga (Virgen de la Victoria), Universidad de Malaga,
+ 29010 Malaga, Spain. javier.baltar.boileve@sergas.es.
+ Martinez, J Alfredo. Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra (UNAV) and IdiSNA, Navarra Institute for Health Research, 31009 Pamplona, Spain. fjtinahones@hotmail.com.
+ Martinez, J Alfredo. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. fjtinahones@hotmail.com.
+ Martinez, J Alfredo. Program for Precision Nutrition, IMDEA, 28049 Madrid, Spain. fjtinahones@hotmail.com.
+ Crujeiras, Ana B. Division of Endocrinology, Department of Medicine, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Instituto de Investigacion Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, Spain. anabelencrujeiras@hotmail.com.
+ Crujeiras, Ana B. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. anabelencrujeiras@hotmail.com.
+ Crujeiras, Ana B. Laboratory of Epigenomics in Endocrinology and Nutrition, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. anabelencrujeiras@hotmail.com.
+ Casanueva, Felipe F. Division of Endocrinology, Department of Medicine, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Instituto de Investigacion Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, Spain. endocrine@usc.es.
+ Casanueva, Felipe F. CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain. endocrine@usc.es.
+MeSH Subject Headings
+ Adiposity
+ Bariatric Surgery/ae [Adverse Effects]
+ *Bariatric Surgery
+ Biomarkers/bl [Blood]
+ Caloric Restriction/ae [Adverse Effects]
+ *Caloric Restriction
+ Case-Control Studies
+ Diet, Ketogenic/ae [Adverse Effects]
+ *Diet, Ketogenic
+ Female
+ *Fibronectins/bl [Blood]
+ Humans
+ *Interleukin-8/bl [Blood]
+ Male
+ *Matrix Metalloproteinase 2/bl [Blood]
+ *Muscle, Skeletal/me [Metabolism]
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Spain
+ Time Factors
+ Treatment Outcome
+ Weight Loss
+Keyword Heading
+ PnK method
+ bariatric surgery
+ body composition
+ fat free mass
+ ketogenic diet
+ low-calorie diet
+ obesity
+ protein diet
+ very low-energy diet
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ : The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate whether a very low-calorie ketogenic (VLCK) diet may modulate myokine levels, in addition to changes in body composition, compared to a standard, balanced low-calorie (LC) diet or bariatric surgery in patients with obesity. Body composition, ketosis, insulin sensitivity and myokines were evaluated in 79 patients with overweight/obesity after a therapy to lose weight with a VLCK diet, a LC diet or bariatric surgery. The follow-up was 6 months. The weight loss therapies induced changes in myokine levels in association with changes in body composition and biochemical parameters. The effects on circulating myokine levels compared to those at baseline were stronger after the VLCK diet than LC diet or bariatric surgery. Differences reached statistical significance for IL-8, MMP2 and irisin. In conclusion, nutritional interventions or bariatric surgery to lose weight induces changes in circulating myokine levels, being this effect potentially most notable after following a VLCK diet.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (CXCL8 protein, human). 0 (FNDC5 protein, human). 0 (Fibronectins). 0 (Interleukin-8). EC 3-4-24-24 (MMP2 protein, human). EC 3-4-24-24 (Matrix Metalloproteinase 2).
+Publication Type
+ Comparative Study. Journal Article. Multicenter Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11102368
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Sajoux&issn=2072-6643&title=Nutrients&atitle=Effect+of+a+Very-Low-Calorie+Ketogenic+Diet+on+Circulating+Myokine+Levels+Compared+with+the+Effect+of+Bariatric+Surgery+or+a+Low-Calorie+Diet+in+Patients+with+Obesity.&volume=11&issue=10&spage=&epage=&date=2019&doi=10.3390%2Fnu11102368&pmid=31590286&sid=OVID:medline
+
+<2010>
+Unique Identifier
+ 31590272
+Title
+ Obesity and 25(OH)D Serum Concentration Are More Important than Vitamin D Intake for Changes in Nutritional Status Indicators: A Population-Based Longitudinal Study in a State Capital City in Southern Brazil.
+Source
+ Nutrients. 11(10), 2019 Oct 04.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cembranel F; d'Orsi E; Jakovljevic Pudla Wagner K; Weber Corseuil Giehl M; Moreno YMF; Gonzalez-Chica DA
+Authors Full Name
+ Cembranel, Francieli; d'Orsi, Eleonora; Jakovljevic Pudla Wagner, Katia; Weber Corseuil Giehl, Marui; Moreno, Yara Maria Franco; Gonzalez-Chica, David Alejandro.
+Institution
+ Cembranel, Francieli. Department of Nutrition, Federal University of Santa Catarina. Trindade University Campus, Florianopolis, Santa Catarina 88040-370, Brazil. francieli.cembranel@ufsc.br.
+ d'Orsi, Eleonora. Department of Public Health, Federal University of Santa Catarina. Trindade University Campus, Florianopolis, Santa Catarina 88040-370, Brazil.
+ d'Orsi, Eleonora. The Bernard Lown Scholars in Cardiovascular Health Program. Department of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Room 1210, Boston, MA 02115, USA.
+ Jakovljevic Pudla Wagner, Katia. Center for Rural Sciences. Bioscience and Unique Health Coordination. Federal University of Santa Catarina. Curitibanos University Campus, Curitibanos, Santa Catarina 89520-000, Brazil.
+ Weber Corseuil Giehl, Marui. Health Sciences Department, Federal University of Santa Catarina. Ararangua University Campus, Ararangua, Santa Catarina 88906-072, Brazil.
+ Moreno, Yara Maria Franco. Department of Nutrition, Federal University of Santa Catarina. Trindade University Campus, Florianopolis, Santa Catarina 88040-370, Brazil.
+ Gonzalez-Chica, David Alejandro. Discipline of General Practice, Adelaide Medical School. Room 813, Level 8, Hughes Building, North Terrace Campus, University of Adelaide, Adelaide, SA 5005, Australia.
+MeSH Subject Headings
+ Adult
+ Aged
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Brazil/ep [Epidemiology]
+ Female
+ Humans
+ Longitudinal Studies
+ Male
+ Middle Aged
+ Nutrition Assessment
+ *Nutritional Status
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ Prospective Studies
+ *Recommended Dietary Allowances
+ *Vitamin D/aa [Analogs & Derivatives]
+ Vitamin D/bl [Blood]
+ Vitamin D Deficiency/bl [Blood]
+ Vitamin D Deficiency/di [Diagnosis]
+ Vitamin D Deficiency/ep [Epidemiology]
+ *Vitamin D Deficiency/pp [Physiopathology]
+ *Vitamins/ad [Administration & Dosage]
+ Vitamins/bl [Blood]
+ Waist Circumference
+ Weight Gain
+Keyword Heading
+ 25(OH)D serum concentration
+ body mass index
+ dietary vitamin D intake
+ prospective study
+ waist circumference
+ weight
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Our objective was to investigate the relationship between dietary vitamin D intake and serum concentration of vitamin D (25(OH)D) on changes in body weight, waist circumference (WC), and body mass index (BMI), and to determine if this relationship changes between obese and non-obese individuals at baseline and those who have or do not have 25(OH)D deficiency. This was a prospective study with a sample of 572 individuals aged 25-65 years, who were participants in the cohort study EpiFloripa Adults. Changes in weight (in kg), BMI, and WC between 2012 and 2014 were evaluated as outcomes. The main exposure was the dietary intake of vitamin D (2012), and the 25(OH)D serum concentration was secondary. When the analyses were stratified by the presence of obesity in the baseline, among obese individuals it was observed that those in the extreme categories of vitamin D intake had an average gain of 3.0 kg in weight, 0.9 kg/m2 in BMI, and 1.7-2.7 cm in WC. When 25(OH)D serum concentration were incorporated into the analyses, it was observed that non-obese subjects not having 25(OH)D deficiency had a mean reduction of 2.3 cm in WC. In conclusion, the increases in body weight, BMI, and WC were higher over time in obese patients with deficient 25(OH)D serum concentration, regardless of dietary vitamin D intake.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Vitamins). 1406-16-2 (Vitamin D). A288AR3C9H (25-hydroxyvitamin D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11102366
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cembranel&issn=2072-6643&title=Nutrients&atitle=Obesity+and+25%28OH%29D+Serum+Concentration+Are+More+Important+than+Vitamin+D+Intake+for+Changes+in+Nutritional+Status+Indicators%3A+A+Population-Based+Longitudinal+Study+in+a+State+Capital+City+in+Southern+Brazil.&volume=11&issue=10&spage=&epage=&date=2019&doi=10.3390%2Fnu11102366&pmid=31590272&sid=OVID:medline
+
+<2011>
+Unique Identifier
+ 31589561
+Title
+ New Insights on Obesity and Diabetes from Gut Microbiome Alterations in Egyptian Adults.
+Source
+ Omics a Journal of Integrative Biology. 23(10):477-485, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Salah M; Azab M; Ramadan A; Hanora A
+Authors Full Name
+ Salah, Mohammed; Azab, Marwa; Ramadan, Ahmed; Hanora, Amro.
+Institution
+ Salah, Mohammed. Department of Microbiology and Immunology, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
+ Azab, Marwa. Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
+ Ramadan, Ahmed. Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
+ Hanora, Amro. Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Biomarkers
+ DNA Barcoding, Taxonomic
+ *Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus/et [Etiology]
+ Egypt
+ Female
+ *Gastrointestinal Microbiome
+ High-Throughput Nucleotide Sequencing
+ Humans
+ Male
+ Metagenomics/mt [Methods]
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ *Obesity/et [Etiology]
+ RNA, Ribosomal, 16S/ge [Genetics]
+Keyword Heading
+ Egypt
+ diabetes
+ gut microbiota
+ metagenomics
+ microbiome
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity and diabetes are reaching epidemic levels globally. Metagenomics and microbiome science have recently emerged as new tools for studying common complex human diseases. We report in this study notable differences in gut microbiome in adult patients with obesity and diabetes in Egypt. The experimental design was based on comparisons of four study groups: (1) Controls (C) with a normal body mass index, without obesity or diabetes, (2) Obese adults (O) without diabetes, (3) adults with diabetes (D) who are not obese, and (4) Adults who are both obese and diabetic (OD). In a total study sample of 60 participants, we sequenced the 16S ribosomal RNA (rRNA) gene using the Illumina MiSeq platform. Alpha diversity analysis revealed greater diversity in bacterial communities of (D) than controls. Phylum-level analysis identified a trend for overrepresentation of Bacteroidetes (p < 0.07) in (O) and (D) than controls. The ratio of Firmicutes/Bacteroidetes (F/B) displayed a remarkable increase in (OD) than controls. At genus level, Faecalibacterium (p < 0.05) and Akkermansia (p < 0.001) distinguished (O) from controls, while Fusobacterium (p < 0.001) and Bacteroides (p < 0.001) was significantly more abundant in (OD) compared with D. Surprisingly, isoquinoline, quinone and ubiquinone alkaloid biosynthesis were overrepresented in controls compared with other three study groups. Presumably, the latter observation might potentially suggest an antihyperglycemic activity of the gut microbiota. In conclusion, the health state of the adults in our study defined the composition of the gut microbiota. Moreover, obesity and diabetes were associated with remarkably enriched populations of Firmicutes and Bacteroidetes. The abundance of Fusobacterium is worth further research and exploration as a candidate biomarker for prediabetes especially in obese individuals. The potential antihyperglycemic activity of the gut microbiota is also noteworthy for future studies in other world populations.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Ribosomal, 16S).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1089%2fomi.2019.0063
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Salah&issn=1536-2310&title=Omics+a+Journal+of+Integrative+Biology&atitle=New+Insights+on+Obesity+and+Diabetes+from+Gut+Microbiome+Alterations+in+Egyptian+Adults.&volume=23&issue=10&spage=477&epage=485&date=2019&doi=10.1089%2Fomi.2019.0063&pmid=31589561&sid=OVID:medline
+
+<2012>
+Unique Identifier
+ 31587110
+Title
+ Metabolomics: a search for biomarkers of visceral fat and liver fat content.
+Source
+ Metabolomics. 15(10):139, 2019 10 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Boone S; Mook-Kanamori D; Rosendaal F; den Heijer M; Lamb H; de Roos A; le Cessie S; Willems van Dijk K; de Mutsert R
+Authors Full Name
+ Boone, Sebastiaan; Mook-Kanamori, Dennis; Rosendaal, Frits; den Heijer, Martin; Lamb, Hildo; de Roos, Albert; le Cessie, Saskia; Willems van Dijk, Ko; de Mutsert, Renee.
+Institution
+ Boone, Sebastiaan. Department of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC, Leiden, The Netherlands. s.c.boone@lumc.nl.
+ Mook-Kanamori, Dennis. Department of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC, Leiden, The Netherlands.
+ Mook-Kanamori, Dennis. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
+ Rosendaal, Frits. Department of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC, Leiden, The Netherlands.
+ den Heijer, Martin. Department of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC, Leiden, The Netherlands.
+ den Heijer, Martin. Department of Endocrinology, VU Medical Centre, Amsterdam, The Netherlands.
+ Lamb, Hildo. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
+ de Roos, Albert. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
+ le Cessie, Saskia. Department of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC, Leiden, The Netherlands.
+ le Cessie, Saskia. Department of Biomedical Data Sciences, Section Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.
+ Willems van Dijk, Ko. Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
+ Willems van Dijk, Ko. Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
+ Willems van Dijk, Ko. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
+ de Mutsert, Renee. Department of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC, Leiden, The Netherlands.
+MeSH Subject Headings
+ Adipose Tissue/ch [Chemistry]
+ *Adipose Tissue/me [Metabolism]
+ Aged
+ *Biomarkers/bl [Blood]
+ Blood Glucose
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Humans
+ Intra-Abdominal Fat/ch [Chemistry]
+ *Intra-Abdominal Fat/me [Metabolism]
+ Liver/ch [Chemistry]
+ *Liver/me [Metabolism]
+ Male
+ *Metabolomics/mt [Methods]
+ Middle Aged
+ Netherlands
+ Obesity/me [Metabolism]
+ Plasma/ch [Chemistry]
+ Triglycerides/an [Analysis]
+Keyword Heading
+ Biomarkers
+ Liver fat
+ Metabolomics
+ Visceral adipose tissue
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTODUCTION: Excess visceral and liver fat are known risk factors for cardiometabolic disorders. Metabolomics might allow for easier quantification of these ectopic fat depots, instead of using invasive and costly tools such as MRI or approximations such as waist circumference.
+
+ OBJECTIVE: We explored the potential use of plasma metabolites as biomarkers of visceral adipose tissue (VAT) and hepatic triglyceride content (HTGC).
+
+ METHODS: We performed a cross-sectional analysis of a subset of the Netherlands Epidemiology of Obesity study. Plasma metabolite profiles were determined using the Biocrates AbsoluteIDQ p150 kit in 176 individuals with normal fasting plasma glucose. VAT was assessed with magnetic resonance imaging and HTGC with proton-MR spectroscopy. We used linear regression to investigate the associations of 190 metabolite variables with VAT and HTGC.
+
+ RESULTS: After adjustment for age, sex, total body fat, currently used approximations of visceral and liver fat, and multiple testing, three metabolite ratios were associated with VAT. The strongest association was the lysophosphatidylcholines to total phosphatidylcholines (PCs) ratio [- 14.1 (95% CI - 21.7; - 6.6) cm2 VAT per SD of metabolite concentration]. Four individual metabolites were associated with HTGC, especially the diacyl PCs of which C32:1 was the strongest at a 1.31 (95% CI 1.14; 1.51) fold increased HTGC per SD of metabolite concentration.
+
+ CONCLUSION: Metabolomics may be a useful tool to identify biomarkers of visceral fat and liver fat content that have added diagnostic value over current approximations. Replication studies are required to validate the diagnostic value of these metabolites.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11306-019-1599-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Boone&issn=1573-3882&title=Metabolomics&atitle=Metabolomics%3A+a+search+for+biomarkers+of+visceral+fat+and+liver+fat+content.&volume=15&issue=10&spage=139&epage=&date=2019&doi=10.1007%2Fs11306-019-1599-x&pmid=31587110&sid=OVID:medline
+
+<2013>
+Unique Identifier
+ 31585776
+Title
+ High fat diet downregulates regulatory T cells in the myocardium of spontaneous hypertensive rats.
+Source
+ Nutrition Metabolism & Cardiovascular Diseases. 29(11):1254-1260, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hong SK; Choo EH; Ihm SH; Chang KY
+Authors Full Name
+ Hong, Seul K; Choo, Eun H; Ihm, Sang H; Chang, Ki Y.
+Institution
+ Hong, Seul K. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Pharos Vaccine Inc., Seongnam, South Korea.
+ Choo, Eun H. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
+ Ihm, Sang H. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address: heartihmsh@yahoo.co.kr.
+ Chang, Ki Y. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ *Cardiomyopathies/im [Immunology]
+ Cardiomyopathies/me [Metabolism]
+ Cardiomyopathies/pa [Pathology]
+ *Diet, High-Fat
+ Disease Models, Animal
+ Down-Regulation
+ Fibrosis
+ Forkhead Transcription Factors/im [Immunology]
+ Forkhead Transcription Factors/me [Metabolism]
+ Lymph Nodes/im [Immunology]
+ Male
+ Mediastinum
+ *Myocardium/im [Immunology]
+ Myocardium/me [Metabolism]
+ Myocardium/pa [Pathology]
+ *Obesity/im [Immunology]
+ Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Rats, Inbred SHR
+ Rats, Inbred WKY
+ *T-Lymphocytes, Regulatory/im [Immunology]
+ T-Lymphocytes, Regulatory/me [Metabolism]
+Keyword Heading
+ High fat diet
+ Inflammation
+ Myocardial fibrosis
+ Obesity
+ Regulatory T cell
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND AND AIM: Regulatory T cells (Tregs) play an important role in cardiovascular complications with the immune response. However, the role of Tregs in high fat diet (HFD)-induced myocardial fibrosis has not been fully elucidated to date. Therefore, we investigated whether HFD suppresses Tregs activation in the myocardium of spontaneously hypertensive rats (SHRs), which aggregates myocardial fibrosis.
+
+ METHODS AND RESULTS: Eight-week-old male SHRs were fed to either HFD or control diet (CHO) groups for 12 weeks. We measured Tregs (CD4+FoxP3+) in the heart and mediastinal lymph nodes (LNs). The flow cytometry analysis confirmed that SHR-HFD exhibited a decreased Tregs compared to that of SHR-CHO in the heart and mediastinal LNs. Furthermore, the CD4 and FoxP3 antigens were used in the immunofluorescence microscopy of Tregs in the heart tissues. In the heart, dual staining for the Treg population was increased more in SHR-CHO than it was in SHR-HFD rats. In line with these findings, SHR-HFD significantly exacerbated myocardial fibrosis.
+
+ CONCLUSION: We found that diet-induced obesity typically showed an exacerbated myocardial fibrosis and down-regulation of Tregs pathway in the heart and mediastinal LNs. Therefore, we suggest that the up-regulation of Tregs may be a promising therapeutic approach to preventing obesity induced heart failure. Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Forkhead Transcription Factors). 0 (Foxp3 protein, rat).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.numecd.2019.08.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hong&issn=0939-4753&title=Nutrition+Metabolism+%26+Cardiovascular+Diseases&atitle=High+fat+diet+downregulates+regulatory+T+cells+in+the+myocardium+of+spontaneous+hypertensive+rats.&volume=29&issue=11&spage=1254&epage=1260&date=2019&doi=10.1016%2Fj.numecd.2019.08.004&pmid=31585776&sid=OVID:medline
+
+<2014>
+Unique Identifier
+ 31581733
+Title
+ Specific Wheat Fractions Influence Hepatic Fat Metabolism in Diet-Induced Obese Mice.
+Source
+ Nutrients. 11(10), 2019 Oct 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Graf D; Weitkunat K; Dotsch A; Liebisch G; Doring M; Kruger R; Vatareck E; von Coburg E; Loh G; Watzl B
+Authors Full Name
+ Graf, Daniela; Weitkunat, Karolin; Dotsch, Andreas; Liebisch, Gerhard; Doring, Maik; Kruger, Ralf; Vatareck, Elisabeth; von Coburg, Elena; Loh, Gunnar; Watzl, Bernhard.
+Institution
+ Graf, Daniela. Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, Germany. Daniela.Graf@mri.bund.de.
+ Weitkunat, Karolin. Department of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. Karolin.Weitkunat@dife.de.
+ Dotsch, Andreas. Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, Germany. Andreas.Doetsch@mri.bund.de.
+ Dotsch, Andreas. Institute of Functional Interfaces, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany. Andreas.Doetsch@mri.bund.de.
+ Liebisch, Gerhard. Institute of Clinical Chemistry, University Hospital Regensburg, 93053 Regensburg, Germany. Gerhard.Liebisch@klinik.uni-regensburg.de.
+ Doring, Maik. Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, Germany. Maik.Doering@mri.bund.de.
+ Kruger, Ralf. Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, Germany. Ralf.Krueger@mri.bund.de.
+ Vatareck, Elisabeth. Institute of Functional Interfaces, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany. Elisabeth.Vatareck@helmholtz-hzi.de.
+ von Coburg, Elena. Department of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. coburg@uni-potsdam.de.
+ Loh, Gunnar. Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, Germany. Dominic.Stoll@mri.bund.de.
+ Watzl, Bernhard. Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, Germany.
+MeSH Subject Headings
+ Animal Feed
+ Animals
+ Bacteria/ge [Genetics]
+ Bacteria/me [Metabolism]
+ Biomarkers/bl [Blood]
+ *Diet, High-Fat
+ Dietary Fiber
+ *Dietary Supplements
+ Disease Models, Animal
+ *Edible Grain
+ Flour
+ Gastrointestinal Microbiome
+ *Lipids/bl [Blood]
+ *Liver/me [Metabolism]
+ Male
+ Mice, Inbred C57BL
+ Nutritive Value
+ *Obesity/dh [Diet Therapy]
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Plant Proteins
+ *Triticum
+Keyword Heading
+ SCFA
+ aleurone
+ bran
+ lipid metabolism
+ microbiota
+ obesity
+ wheat
+ whole grain
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Low whole grain consumption is a risk factor for the development of non-communicable diseases such as type 2 diabetes. Dietary fiber and phytochemicals are bioactive grain compounds, which could be involved in mediating these beneficial effects. These compounds are not equally distributed in the wheat grain, but are enriched in the bran and aleurone fractions. As little is known on physiological effects of different wheat fractions, the aim of this study was to investigate this aspect in an obesity model. For twelve weeks, C57BL/6J mice were fed high-fat diets (HFD), supplemented with one of four wheat fractions: whole grain flour, refined white flour, bran, or aleurone. The different diets did not affect body weight, however bran and aleurone decreased liver triglyceride content, and increased hepatic n-3 polyunsaturated fatty acid (PUFA) concentrations. Furthermore, lipidomics analysis revealed increased PUFA concentration in the lipid classes of phosphatidylcholine (PC), PC-ether, and phosphatidylinositol in the plasma of mice fed whole grain, bran, and aleurone supplemented diets, compared to refined white flour. Furthermore, bran, aleurone, and whole grain supplemented diets increased microbial alpha-diversity, but only bran and aleurone increased the cecal concentrations of short-chain fatty acids. The effects on hepatic lipid metabolism might thus at least partially be mediated by microbiota-dependent mechanisms.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Fiber). 0 (Lipids). 0 (Plant Proteins). 0 (aleurone).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11102348
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Graf&issn=2072-6643&title=Nutrients&atitle=Specific+Wheat+Fractions+Influence+Hepatic+Fat+Metabolism+in+Diet-Induced+Obese+Mice.&volume=11&issue=10&spage=&epage=&date=2019&doi=10.3390%2Fnu11102348&pmid=31581733&sid=OVID:medline
+
+<2015>
+Unique Identifier
+ 31581657
+Title
+ Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases. [Review]
+Source
+ International Journal of Molecular Sciences. 20(19), 2019 Oct 02.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ruiz-Ojeda FJ; Mendez-Gutierrez A; Aguilera CM; Plaza-Diaz J
+Authors Full Name
+ Ruiz-Ojeda, Francisco Javier; Mendez-Gutierrez, Andrea; Aguilera, Concepcion Maria; Plaza-Diaz, Julio.
+Institution
+ Ruiz-Ojeda, Francisco Javier. Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain. francisco.ruiz@helmholtz-muenchen.de.
+ Ruiz-Ojeda, Francisco Javier. Instituto de Investigacion Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain. francisco.ruiz@helmholtz-muenchen.de.
+ Ruiz-Ojeda, Francisco Javier. RG Adipocytes and metabolism, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Center Munich, 85764 Neuherberg, Munich, Germany. francisco.ruiz@helmholtz-muenchen.de.
+ Mendez-Gutierrez, Andrea. Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain. andmengut@gmail.com.
+ Mendez-Gutierrez, Andrea. Instituto de Investigacion Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain. andmengut@gmail.com.
+ Mendez-Gutierrez, Andrea. Institute of Nutrition and Food Technology "Jose Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. 18016 Armilla, Granada, Spain. andmengut@gmail.com.
+ Mendez-Gutierrez, Andrea. CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. andmengut@gmail.com.
+ Aguilera, Concepcion Maria. Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain. caguiler@ugr.es.
+ Aguilera, Concepcion Maria. Instituto de Investigacion Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain. caguiler@ugr.es.
+ Aguilera, Concepcion Maria. Institute of Nutrition and Food Technology "Jose Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. 18016 Armilla, Granada, Spain. caguiler@ugr.es.
+ Aguilera, Concepcion Maria. CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. caguiler@ugr.es.
+ Plaza-Diaz, Julio. Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain. jrplaza@ugr.es.
+ Plaza-Diaz, Julio. Instituto de Investigacion Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain. jrplaza@ugr.es.
+ Plaza-Diaz, Julio. Institute of Nutrition and Food Technology "Jose Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. 18016 Armilla, Granada, Spain. jrplaza@ugr.es.
+MeSH Subject Headings
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers
+ *Extracellular Matrix/me [Metabolism]
+ Humans
+ Insulin Resistance
+ Integrins/me [Metabolism]
+ Metabolic Diseases/et [Etiology]
+ *Metabolic Diseases/me [Metabolism]
+ Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+Keyword Heading
+ adipose tissue
+ extracellular matrix
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The extracellular matrix (ECM) is a network of different proteins and proteoglycans that controls differentiation, migration, repair, survival, and development, and it seems that its remodeling is required for healthy adipose tissue expansion. Obesity drives an excessive lipid accumulation in adipocytes, which provokes immune cells infiltration, fibrosis (an excess of deposition of ECM components such as collagens, elastin, and fibronectin) and inflammation, considered a consequence of local hypoxia, and ultimately insulin resistance. To understand the mechanism of this process is a challenge to treat the metabolic diseases. This review is focused at identifying the putative role of ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it is affected in obesity, and subsequently the importance of an appropriate ECM remodeling in adipose tissue expansion to prevent metabolic diseases.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Integrins).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20194888
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ruiz-Ojeda&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Extracellular+Matrix+Remodeling+of+Adipose+Tissue+in+Obesity+and+Metabolic+Diseases.&volume=20&issue=19&spage=4888&epage=&date=2019&doi=10.3390%2Fijms20194888&pmid=31581657&sid=OVID:medline
+
+<2016>
+Unique Identifier
+ 31581253
+Title
+ Obesity-associated insulin resistance adversely affects skin function.
+Source
+ PLoS ONE [Electronic Resource]. 14(10):e0223528, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aoki M; Murase T
+Author NameID
+ Murase, Takatoshi; ORCID: https://orcid.org/0000-0002-5496-0133
+Authors Full Name
+ Aoki, Masafumi; Murase, Takatoshi.
+Institution
+ Aoki, Masafumi. Biological Science Laboratories, Kao Corporation, Ichikai-machi, Haga-gun, Tochigi, Japan.
+ Murase, Takatoshi. Biological Science Laboratories, Kao Corporation, Ichikai-machi, Haga-gun, Tochigi, Japan.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Blood Glucose
+ Diet, High-Fat
+ Gene Expression
+ *Insulin Resistance
+ Keratinocytes/me [Metabolism]
+ Male
+ Mice
+ Muscle, Skeletal/me [Metabolism]
+ Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ *Skin/me [Metabolism]
+ *Skin/pp [Physiopathology]
+Abstract
+ The aim of this study was to identify changes in skin function associated with obesity and the mechanisms underlying these changes. Functional changes and gene expression in skin were investigated in C57BL/6J mice fed either a control or high-fat diet (HFD). The insulin responsiveness of the skin and skeletal muscle was also evaluated. The effects of inhibiting insulin signaling and altered glucose concentration on skin function-associated molecules and barrier function were analyzed in keratinocytes. HFD-fed mice were not only severely obese, but also exhibited impaired skin barrier function and diminished levels of glycerol transporter aquaporin-3, keratins, and desmosomal proteins involved in maintaining skin structure. Moreover, the expression of cell cycle regulatory molecules was altered. Insulin signaling was attenuated in the skin and skeletal muscle of HFD-fed mice. In keratinocytes, inhibition of insulin signaling leads to decreased keratin expression and diminished barrier function, and higher glucose concentrations increased the expression of CDK inhibitor 1A and 1C, which are associated with cell-cycle arrest. Obesity-associated impairment of skin function can be attributed to structural fragility, abnormal glycerol transport, and dysregulated proliferation of epidermal cells. These alterations are at least partly due to cutaneous insulin resistance and hyperglycemia.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0223528
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aoki&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Obesity-associated+insulin+resistance+adversely+affects+skin+function.&volume=14&issue=10&spage=e0223528&epage=&date=2019&doi=10.1371%2Fjournal.pone.0223528&pmid=31581253&sid=OVID:medline
+
+<2017>
+Unique Identifier
+ 31580380
+Title
+ A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model.
+Source
+ Food & Function. 10(10):6851-6857, 2019 Oct 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rochester E; Wickman BE; Bell A; Simecka C; Clayton ZS; Hakkak R; Hooshmand S
+Authors Full Name
+ Rochester, Eric; Wickman, Brooke E; Bell, Andrea; Simecka, Christy; Clayton, Zachary S; Hakkak, Reza; Hooshmand, Shirin.
+Institution
+ Rochester, Eric . School of Exercise and Nutritional Sciences, San Diego State University, San Diego, California, USA. shooshmand@sdsu.edu.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Amino Acids/bl [Blood]
+ Animals
+ Biomarkers
+ Body Weight/de [Drug Effects]
+ *Bone Density/de [Drug Effects]
+ Bone Density/ge [Genetics]
+ Bone and Bones/de [Drug Effects]
+ *Diet
+ Dietary Supplements
+ Disease Models, Animal
+ Energy Intake
+ Female
+ Femur
+ *Gene Expression/de [Drug Effects]
+ *Isoflavones/pd [Pharmacology]
+ Obesity/dh [Diet Therapy]
+ *Obesity/dt [Drug Therapy]
+ Osteocalcin/bl [Blood]
+ *Osteogenesis/de [Drug Effects]
+ Osteogenesis/ge [Genetics]
+ Osteoporosis/dh [Diet Therapy]
+ Osteoporosis/dt [Drug Therapy]
+ Phytoestrogens/pd [Pharmacology]
+ Rats
+ Rats, Zucker
+Abstract
+ Phytoestrogens are nonsteroidal plant compounds with similar chemical structures to mammalian estrogen capable of mimicking the effect of estrogen in selective tissues. A diet rich in phytoestrogens is associated with a variety of health benefits including decreased risks for heart disease, breast cancer, and osteoporosis. Obesity has long thought to be associated with improved bone density due to increased mechanical loading, but recent literature suggests obesity may actually decrease bone health. Daidzein, a soy-derived phytoestrogen, has been shown to improve parameters of bone health in lean animal models of osteoporosis but has not been tested in obese animals. Following a one-week acclimation to a standard AIN-93G diet, 19 five-week-old female obese Zucker rats (OZR) were randomly assigned to a modified AIN-93G diet containing either high daidzein (HD, 0.121 g kg-1 feed) or low daidzein (LD, 0.01 g kg-1 feed). After 8 weeks, tibias and femurs were removed to assess true density (Archimedes principal), mechanical strength (three-point bending test), and femoral osteogenic gene expression. Serum was collected to assess osteocalcin and deoxypyridinoline. Our results indicated that there were no significant differences between the measures for tibial or femoral true density or mechanical strength for the rats in the HD and LD diet groups. Similarly, there were no significant differences in gene expressions related to osteogenic pathways, or serum biomarkers of bone formation and resorption. Overall, an increased dose of daidzein from soy protein supplementation does not elicit an improvement in markers of bone health in obese Zucker rats.
+Registry Number/Name of Substance
+ 0 (Amino Acids). 0 (Biomarkers). 0 (Isoflavones). 0 (Phytoestrogens). 104982-03-8 (Osteocalcin). 6287WC5J2L (daidzein). 90032-33-0 (deoxypyridinoline).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1039%2fc9fo01292c
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rochester&issn=2042-6496&title=Food+%26+Function&atitle=A+diet+containing+high-+versus+low-daidzein+does+not+affect+bone+density+and+osteogenic+gene+expression+in+the+obese+Zucker+rat+model.&volume=10&issue=10&spage=6851&epage=6857&date=2019&doi=10.1039%2Fc9fo01292c&pmid=31580380&sid=OVID:medline
+
+<2018>
+Unique Identifier
+ 31575379
+Title
+ The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study.
+Source
+ Cardiovascular Diabetology. 18(1):128, 2019 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kim YG; Han KD; Choi JI; Boo KY; Kim DY; Oh SK; Lee KN; Shim J; Kim JS; Kim YH
+Author NameID
+ Choi, Jong-Il; ORCID: https://orcid.org/0000-0001-6617-508X
+Authors Full Name
+ Kim, Yun Gi; Han, Kyung-Do; Choi, Jong-Il; Boo, Ki Yung; Kim, Do Young; Oh, Suk-Kyu; Lee, Kwang-No; Shim, Jaemin; Kim, Jin Seok; Kim, Young-Hoon.
+Institution
+ Kim, Yun Gi. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.
+ Han, Kyung-Do. Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
+ Choi, Jong-Il. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea. jongilchoi@korea.ac.kr.
+ Choi, Jong-Il. Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Medical Center, 73 Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. jongilchoi@korea.ac.kr.
+ Boo, Ki Yung. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.
+ Kim, Do Young. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.
+ Oh, Suk-Kyu. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.
+ Lee, Kwang-No. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.
+ Shim, Jaemin. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.
+ Kim, Jin Seok. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.
+ Kim, Young-Hoon. Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.
+MeSH Subject Headings
+ Adult
+ Aged
+ Atrial Fibrillation/di [Diagnosis]
+ *Atrial Fibrillation/ep [Epidemiology]
+ Atrial Fibrillation/pp [Physiopathology]
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ *Body Weight
+ Databases, Factual
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/di [Diagnosis]
+ *Diabetes Mellitus/ep [Epidemiology]
+ Female
+ Heart Rate
+ Humans
+ Incidence
+ Male
+ Middle Aged
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ Obesity/pp [Physiopathology]
+ Prevalence
+ Prognosis
+ Republic of Korea/ep [Epidemiology]
+ Risk Assessment
+ Risk Factors
+ Thinness/di [Diagnosis]
+ *Thinness/ep [Epidemiology]
+ Thinness/pp [Physiopathology]
+ Time Factors
+Keyword Heading
+ Atrial fibrillation
+ Body weight
+ Diabetes
+ Waist circumference
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Being obese or underweight, and having diabetes are important risk factors for new-onset atrial fibrillation (AF). However, it is unclear whether there is any interaction between body weight and diabetes in regard to development of new-onset AF. We aimed to evaluate the role of body weight status and various stage of diabetes on new-onset AF.
+
+ METHODS: This was a nationwide population based study using National Health Insurance Service (NHIS) data. A total of 9,797,418 patients who underwent national health check-ups were analyzed. Patients were classified as underweight [body mass index (BMI) < 18.5], normal reference group (18.5 <= BMI < 23.0), upper normal (23.0 <= BMI < 25.0), overweight (25.0 <= BMI < 30.0), or obese (BMI >= 30.0) based on BMI. Diabetes were categorized as non-diabetic, impaired fasting glucose (IFG), new-onset diabetes, diabetes < 5 years, and diabetes >= 5 years. Primary outcome end point was new-onset AF. New-onset AF was defined as one inpatient or two outpatient records of International Classification of Disease, Tenth Revision (ICD-10) codes in patients without prior AF diagnosis.
+
+ RESULTS: During 80,130,161 patient*years follow-up, a total of 196,136 new-onset AF occurred. Obese [hazard ration (HR) = 1.327], overweight (HR = 1.123), upper normal (HR = 1.040), and underweight (HR = 1.055) patients showed significantly increased risk of new-onset AF compared to the normal reference group. Gradual escalation in the risk of new-onset AF was observed along with advancing diabetic stage. Body weight status and diabetes were independently associated with new-onset AF and at the same time, had synergistic effects on the risk of new-onset AF with obese diabetic patients having the highest risk (HR = 1.823).
+
+ CONCLUSIONS: Patients with obesity, overweight, underweight, and diabetes had significantly increased risk of new-onset AF. Body weight status and diabetes had synergistic effects on the risk of new-onset AF. The risk of new-onset AF increased gradually with advancing diabetic stage. This study suggests that maintaining optimal body weight and glucose homeostasis might prevent new-onset AF.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12933-019-0932-z
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kim&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=The+impact+of+body+weight+and+diabetes+on+new-onset+atrial+fibrillation%3A+a+nationwide+population+based+study.&volume=18&issue=1&spage=128&epage=&date=2019&doi=10.1186%2Fs12933-019-0932-z&pmid=31575379&sid=OVID:medline
+
+<2019>
+Unique Identifier
+ 31575375
+Title
+ Effects of 1 year of exercise training versus combined exercise training and weight loss on body composition, low-grade inflammation and lipids in overweight patients with coronary artery disease: a randomized trial.
+Source
+ Cardiovascular Diabetology. 18(1):127, 2019 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Pedersen LR; Olsen RH; Anholm C; Astrup A; Eugen-Olsen J; Fenger M; Simonsen L; Walzem RL; Haugaard SB; Prescott E
+Author NameID
+ Pedersen, Lene Rorholm; ORCID: https://orcid.org/0000-0002-0669-8855
+Authors Full Name
+ Pedersen, Lene Rorholm; Olsen, Rasmus Huan; Anholm, Christian; Astrup, Arne; Eugen-Olsen, Jesper; Fenger, Mogens; Simonsen, Lene; Walzem, Rosemary L; Haugaard, Steen Bendix; Prescott, Eva.
+Institution
+ Pedersen, Lene Rorholm. Department of Cardiology, Bispebjerg University Hospital, University of Copenhagen, Building 67, 1st, Bispebjerg Bakke 23, 2400, Copenhagen, NW, Denmark. lrpedersen@gmail.com.
+ Pedersen, Lene Rorholm. Department of Cardiology, University Hospital of Zealand, Roskilde, University of Copenhagen, Copenhagen, Denmark. lrpedersen@gmail.com.
+ Olsen, Rasmus Huan. Department of Cardiology, Bispebjerg University Hospital, University of Copenhagen, Building 67, 1st, Bispebjerg Bakke 23, 2400, Copenhagen, NW, Denmark.
+ Anholm, Christian. Department of Internal Medicine, Glostrup University Hospital, University of Copenhagen, Copenhagen, Denmark.
+ Astrup, Arne. Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
+ Eugen-Olsen, Jesper. Clinical Research Centre, Hvidovre University Hospital, University of Copenhagen, Copenhagen, Denmark.
+ Fenger, Mogens. Department of Medical Biochemistry, Genetics and Molecular Biochemistry, Hvidovre University Hospital, University of Copenhagen, Copenhagen, Denmark.
+ Simonsen, Lene. Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital, University of Copenhagen, Copenhagen, Denmark.
+ Walzem, Rosemary L. Faculty of Nutrition, Texas A & M University, College Station, TX, USA.
+ Haugaard, Steen Bendix. Department of Internal Medicine, Amager and Hvidovre University Hospital, University of Copenhagen, Copenhagen, Denmark.
+ Prescott, Eva. Department of Cardiology, Bispebjerg University Hospital, University of Copenhagen, Building 67, 1st, Bispebjerg Bakke 23, 2400, Copenhagen, NW, Denmark.
+MeSH Subject Headings
+ *Adiposity
+ Aged
+ Biomarkers/bl [Blood]
+ C-Reactive Protein/me [Metabolism]
+ *Caloric Restriction
+ Coronary Artery Disease/bl [Blood]
+ Coronary Artery Disease/di [Diagnosis]
+ Coronary Artery Disease/pp [Physiopathology]
+ *Coronary Artery Disease/th [Therapy]
+ Denmark
+ Dyslipidemias/bl [Blood]
+ Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/pp [Physiopathology]
+ *Dyslipidemias/th [Therapy]
+ *Exercise Therapy
+ Female
+ Health Status
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/di [Diagnosis]
+ Inflammation/pp [Physiopathology]
+ *Inflammation/th [Therapy]
+ *Inflammation Mediators/bl [Blood]
+ *Lipids/bl [Blood]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Oxygen Consumption
+ Physical Fitness
+ Receptors, Urokinase Plasminogen Activator/bl [Blood]
+ Time Factors
+ Treatment Outcome
+ Tumor Necrosis Factor-alpha/bl [Blood]
+ Weight Loss
+Keyword Heading
+ Aerobic interval training
+ Coronary artery disease
+ Dyslipidaemia
+ Low-grade inflammation
+ Secondary prevention
+ Weight loss
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Dyslipidaemia and low-grade inflammation are central in atherogenesis and linked to overweight and physical inactivity. Lifestyle changes are important in secondary prevention of coronary artery disease (CAD). We compared the effects of combined weight loss and interval training with interval training alone on physical fitness, body composition, dyslipidaemia and low-grade inflammation in overweight, sedentary participants with CAD.
+
+ METHODS: Seventy CAD patients, BMI 28-40 kg/m2 and age 45-75 years were randomised to (1) 12 weeks' aerobic interval training (AIT) at 90% of peak heart rate three times/week followed by 40 weeks' AIT twice weekly or (2) a low energy diet (LED) (800-1000 kcal/day) for 8-10 weeks followed by 40 weeks' weight maintenance including AIT twice weekly and a high-protein/low-glycaemic load diet. Effects of the intervention were evaluated by physical fitness, body weight and composition. Dyslipidaemia was described using both biochemical analysis of lipid concentrations and lipoprotein particle subclass distribution determined by density profiling. Low-grade inflammation was determined by C-reactive protein, soluble urokinase-type plasminogen activator receptor and tumour necrosis factor alpha. Effects on continuous outcomes were tested by mixed-models analysis.
+
+ RESULTS: Twenty-six (74%) AIT and 29 (83%) LED + AIT participants completed the study. At baseline subject included 43 (78%) men; subjects averages were: age 63 years (6.2), body weight 95.9 kg (12.2) and VO2peak 20.7 mL O2/kg/min (4.9). Forty-six (84%) had pre-diabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance). LED + AIT reduced body weight by 7.2 kg (- 8.4; - 6.1) and waist circumference by 6.6 cm (- 7.7; - 5.5) compared to 1.7 kg (- 0.7; - 2.6) and 3.3 cm (- 5.1; - 1.5) after AIT (within-group p < 0.001, between-group p < 0.001 and p = 0.018, respectively). Treatments caused similar changes in VO2peak and lowering of total cholesterol, triglycerides, non-HDL cholesterol and low-grade inflammation. A shift toward larger HDL particles was seen following LED + AIT while AIT elicited no change.
+
+ CONCLUSIONS: Both interventions were feasible. Both groups obtained improvements in VO2peak, serum-lipids and inflammation with superior weight loss and greater central fat loss following LED + AIT. Combined LED induced weight loss and exercise can be recommended to CAD patients. Trial registration NCT01724567, November 12, 2012, retrospectively registered (enrolment ended in April 2013).
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators). 0 (Lipids). 0 (PLAUR protein, human). 0 (Receptors, Urokinase Plasminogen Activator). 0 (TNF protein, human). 0 (Tumor Necrosis Factor-alpha). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Comparative Study. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12933-019-0934-x
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Pedersen&issn=1475-2840&title=Cardiovascular+Diabetology&atitle=Effects+of+1+year+of+exercise+training+versus+combined+exercise+training+and+weight+loss+on+body+composition%2C+low-grade+inflammation+and+lipids+in+overweight+patients+with+coronary+artery+disease%3A+a+randomized+trial.&volume=18&issue=1&spage=127&epage=&date=2019&doi=10.1186%2Fs12933-019-0934-x&pmid=31575375&sid=OVID:medline
+
+<2020>
+Unique Identifier
+ 31564186
+Title
+ Joint Associations of Obesity and NT-proBNP With the Incidence of Atrial Fibrillation in the ARIC Study.
+Source
+ Journal of the American Heart Association. 8(19):e013294, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Almuwaqqat Z; O'Neal WT; Norby FL; Lutsey PL; Selvin E; Soliman EZ; Chen LY; Alonso A
+Authors Full Name
+ Almuwaqqat, Zakaria; O'Neal, Wesley T; Norby, Faye L; Lutsey, Pamela L; Selvin, Elizabeth; Soliman, Elsayed Z; Chen, Lin Y; Alonso, Alvaro.
+Institution
+ Almuwaqqat, Zakaria. Department of Medicine Emory School of Medicine Atlanta GA.
+ Almuwaqqat, Zakaria. Division of Cardiology Department of Medicine Emory University School of Medicine Atlanta GA.
+ Almuwaqqat, Zakaria. Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA.
+ O'Neal, Wesley T. Division of Cardiology Department of Medicine Emory University School of Medicine Atlanta GA.
+ Norby, Faye L. Division of Epidemiology & Community Health School of Public Health University of Minnesota Minneapolis MN.
+ Lutsey, Pamela L. Division of Epidemiology & Community Health School of Public Health University of Minnesota Minneapolis MN.
+ Selvin, Elizabeth. Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health Baltimore MD.
+ Selvin, Elizabeth. Division of General Internal Medicine Department of Medicine Johns Hopkins University Baltimore MD.
+ Soliman, Elsayed Z. Epidemiological Cardiology Research Center Department of Epidemiology and Prevention Wake Forest School of Medicine Winston-Salem NC.
+ Chen, Lin Y. Cardiovascular Division Department of Medicine University of Minnesota Medical School Minneapolis MN.
+ Alonso, Alvaro. Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA.
+MeSH Subject Headings
+ Atrial Fibrillation/bl [Blood]
+ Atrial Fibrillation/di [Diagnosis]
+ *Atrial Fibrillation/ep [Epidemiology]
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Female
+ Humans
+ Incidence
+ Male
+ Middle Aged
+ *Natriuretic Peptide, Brain/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/ep [Epidemiology]
+ *Peptide Fragments/bl [Blood]
+ Prognosis
+ Prospective Studies
+ Risk Assessment
+ Risk Factors
+ Time Factors
+ United States/ep [Epidemiology]
+ Up-Regulation
+Keyword Heading
+ atrial fibrillation
+ brain natriuretic peptide
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Circulating NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, a well-known indicator of atrial wall stress and remodeling, inversely correlate with body mass index. Both are strongly predictive of atrial fibrillation (AF). Their potential interaction in relation to incident AF, however, has not been explored. Methods and Results In total, 9556 participants of the ARIC (Atherosclerosis Risk in Communities) study who had 2 measurements of NT-proBNP and no baseline AF or heart failure were followed from 1996 to 1998 through 2016 for the occurrence of incident AF. Participants were categorized as obese (body mass index >=30) and nonobese (body mass index <30) and by NT-proBNP levels (using the median of 68.2 pg/mL as the cutoff). Over a median follow-up of 18.3 years, we identified 1806 incident cases of AF. Analysis using multivariable Cox regression models showed that obese participants with high NT-proBNP levels at visit 4 had a higher adjusted risk of incident AF (hazard ratio: 3.64; 95% CI, 3.15-4.22) compared with nonobese individuals with low NT-proBNP levels. The association of obesity with AF risk was not modified by NT-proBNP levels (P=0.46 for interaction). Increasing BNP among participants from 1990-1992 to 1996-1998 was associated with increased AF risk. After further adjustment for clinical risk factors and medications, results were similar. Conclusions Individuals who had both elevated body mass index and NT-proBNP and were free of clinically recognized heart failure were at higher risk of AF development. Those who experienced an increase in NT-proBNP levels between visits 2 and 4 were at higher risk of AF.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Peptide Fragments). 0 (pro-brain natriuretic peptide (1-76)). 114471-18-0 (Natriuretic Peptide, Brain).
+Publication Type
+ Journal Article. Multicenter Study. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1161%2fJAHA.119.013294
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Almuwaqqat&issn=2047-9980&title=Journal+of+the+American+Heart+Association&atitle=Joint+Associations+of+Obesity+and+NT-proBNP+With+the+Incidence+of+Atrial+Fibrillation+in+the+ARIC+Study.&volume=8&issue=19&spage=e013294&epage=&date=2019&doi=10.1161%2FJAHA.119.013294&pmid=31564186&sid=OVID:medline
+
+<2021>
+Unique Identifier
+ 31561459
+Title
+ More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer. [Review]
+Source
+ International Journal of Molecular Sciences. 20(19), 2019 Sep 26.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Goralski KB; Jackson AE; McKeown BT; Sinal CJ
+Author NameID
+ Jackson, Ashley E; ORCID: https://orcid.org/0000-0002-7290-3343
+Authors Full Name
+ Goralski, Kerry B; Jackson, Ashley E; McKeown, Brendan T; Sinal, Christopher J.
+Institution
+ Goralski, Kerry B. College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, NS B3H 4R2, Canada. Kerry.Goralski@Dal.Ca.
+ Goralski, Kerry B. Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada. Kerry.Goralski@Dal.Ca.
+ Goralski, Kerry B. Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada. Kerry.Goralski@Dal.Ca.
+ Jackson, Ashley E. Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada. a.jackson13@dal.ca.
+ McKeown, Brendan T. Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada. Brendan.McKeown@Dal.Ca.
+ Sinal, Christopher J. Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada. Christopher.Sinal@dal.ca.
+MeSH Subject Headings
+ Adipokines/ge [Genetics]
+ *Adipokines/me [Metabolism]
+ Animals
+ Biomarkers
+ *Chemokines/me [Metabolism]
+ Disease Susceptibility
+ Humans
+ Immunomodulation
+ *Neoplasms/et [Etiology]
+ *Neoplasms/me [Metabolism]
+ Neoplasms/pa [Pathology]
+ Obesity/co [Complications]
+ Obesity/me [Metabolism]
+ Organ Specificity
+ Protein Binding
+ *Signal Transduction
+Keyword Heading
+ C-C chemokine receptor-like 2
+ G protein-coupled receptor 1
+ adipokine
+ cancer
+ chemerin
+ chemokine-like receptor 1
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Chemerin is widely recognized as an adipokine, with diverse biological roles in cellular differentiation and metabolism, as well as a leukocyte chemoattractant. Research investigating the role of chemerin in the obesity-cancer relationship has provided evidence both for pro- and anti-cancer effects. The tumor-promoting effects of chemerin primarily involve direct effects on migration, invasion, and metastasis as well as growth and proliferation of cancer cells. Chemerin can also promote tumor growth via the recruitment of tumor-supporting mesenchymal stromal cells and stimulation of angiogenesis pathways in endothelial cells. In contrast, the majority of evidence supports that the tumor-suppressing effects of chemerin are immune-mediated and result in a shift from immunosuppressive to immunogenic cell populations within the tumor microenvironment. Systemic chemerin and chemerin produced within the tumor microenvironment may contribute to these effects via signaling through CMKLR1 (chemerin1), GPR1 (chemerin2), and CCLR2 on target cells. As such, inhibition or activation of chemerin signaling could be beneficial as a therapeutic approach depending on the type of cancer. Additional studies are required to determine if obesity influences cancer initiation or progression through increased adipose tissue production of chemerin and/or altered chemerin processing that leads to changes in chemerin signaling in the tumor microenvironment.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (Chemokines). 0 (RARRES2 protein, human).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20194778
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Goralski&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=More+Than+an+Adipokine%3A+The+Complex+Roles+of+Chemerin+Signaling+in+Cancer.&volume=20&issue=19&spage=4778&epage=&date=2019&doi=10.3390%2Fijms20194778&pmid=31561459&sid=OVID:medline
+
+<2022>
+Unique Identifier
+ 31559568
+Title
+ Oxidative Stress Markers and Severity of Obstructive Sleep Apnea.
+Source
+ Advances in Experimental Medicine & Biology. 1222:27-35, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cofta S; Winiarska HM; Plociniczak A; Bielawska L; Brozek A; Piorunek T; Kostrzewska TM; Wysocka E
+Authors Full Name
+ Cofta, S; Winiarska, H M; Plociniczak, A; Bielawska, L; Brozek, A; Piorunek, T; Kostrzewska, T M; Wysocka, E.
+Institution
+ Cofta, S. Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland. scofta@ump.edu.pl.
+ Winiarska, H M. Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland.
+ Plociniczak, A. Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
+ Bielawska, L. Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
+ Brozek, A. Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan, Poland.
+ Piorunek, T. Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland.
+ Kostrzewska, T M. Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland.
+ Wysocka, E. Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
+MeSH Subject Headings
+ Adult
+ Antioxidants/an [Analysis]
+ *Biomarkers/bl [Blood]
+ Glucose Tolerance Test
+ Humans
+ Lipid Peroxides/an [Analysis]
+ Male
+ Middle Aged
+ *Obesity
+ *Oxidative Stress/ph [Physiology]
+ Polysomnography
+ Severity of Illness Index
+ *Sleep Apnea, Obstructive/bl [Blood]
+ Spectrophotometry
+ Thiobarbituric Acid Reactive Substances/an [Analysis]
+Keyword Heading
+ Antioxidant activity
+ Apnea/hypopnea
+ Atherosclerosis
+ Obstructive sleep apnea
+ Oxidative stress
+ Polysomnography
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Oxidative stress underlies both obstructive sleep apnea (OSA) and atherosclerosis. The aim of the study was to assess the markers of oxidative stress in plasma at different stages of OSA in non-smoking obese Caucasian males aged 41-60, with normal oral glucose tolerance test. All patients were subjected to clinical and polysomnographic examinations. The stage of OSA severity was set according to the following criteria of the apnea-hypopnea index (AHI): AHI < 5/h - no disease (OSA-0; n = 26), AHI 5-15/h - mild disease (OSA-1; n = 26), AHI 16-30/h - moderate disease (OSA-2: n = 27), and AHI > 30/h obstructive episodes per hour - severe disease (OSA-3; n = 27). Plasma total antioxidant status (TAS) and thiobarbituric acid-reacting substances (TBARS), reflecting the level of lipid peroxides, were determined spectrophotometrically. We found that TAS decreased and TBARS increased significantly from OSA-0 to OSA-3. We conclude that the oxidative stress markers are conducive to setting the severity of OSA in normoglycemic patients.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers). 0 (Lipid Peroxides). 0 (Thiobarbituric Acid Reactive Substances).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2f5584_2019_433
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cofta&issn=0065-2598&title=Advances+in+Experimental+Medicine+%26+Biology&atitle=Oxidative+Stress+Markers+and+Severity+of+Obstructive+Sleep+Apnea.&volume=1222&issue=&spage=27&epage=35&date=2019&doi=10.1007%2F5584_2019_433&pmid=31559568&sid=OVID:medline
+
+<2023>
+Unique Identifier
+ 31539362
+Title
+ Effect of home-based strength training program on IGF-I, IGFBP-1 and IGFBP-3 in obese Latino boys participating in a 16-week randomized controlled trial.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 32(10):1121-1129, 2019 Oct 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kelly L; Holmberg PM; Schroeder ET; Loza A; Lin X; Moody A; Hughes A; Gibson AM; Kirk A
+Authors Full Name
+ Kelly, Louise; Holmberg, Patrick M; Schroeder, E Todd; Loza, Armando; Lin, Xiao; Moody, Alastai; Hughes, Adrienne; Gibson, Ann-Marie; Kirk, Alison.
+Institution
+ Kelly, Louise. California Lutheran University, Department of Exercise Science, Thousand Oaks, CA, USA.
+ Holmberg, Patrick M. California Lutheran University, Department of Athletics, Thousand Oaks, CA, USA.
+ Schroeder, E Todd. University of Southern California, Division of Biokinesiology and Physical Therapy, School of Dentistry, Los Angeles, CA, USA.
+ Loza, Armando. University of Southern California, Department of Preventive Medicine, Los Angeles, CA, USA.
+ Lin, Xiao. University of Southern California, Department of Preventive Medicine, Los Angeles, CA, USA.
+ Moody, Alastai. California Lutheran University, Department of Biology, Thousand Oaks, CA, USA.
+ Hughes, Adrienne. School of Psychological Sciences and Health, Graham Hills Building, University of Strathclyde, Glasgow, Scotland.
+ Gibson, Ann-Marie. School of Psychological Sciences and Health, Graham Hills Building, University of Strathclyde, Glasgow, Scotland.
+ Kirk, Alison. School of Psychological Sciences and Health, Graham Hills Building, University of Strathclyde, Glasgow, Scotland.
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ Body Composition
+ Case-Control Studies
+ *Exercise
+ Follow-Up Studies
+ Glucose Tolerance Test
+ Hispanic or Latino/sn [Statistics & Numerical Data]
+ Humans
+ *Insulin-Like Growth Factor Binding Protein 1/bl [Blood]
+ *Insulin-Like Growth Factor Binding Protein 3/bl [Blood]
+ *Insulin-Like Growth Factor I/an [Analysis]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ Obesity/th [Therapy]
+ Prognosis
+ *Resistance Training
+Keyword Heading
+ IGF-1
+ IGFBP-1
+ IGFBP-3
+ Latino
+ exercise
+ obese
+ pediatric
+ strength training
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Introduction Growing evidence indicates that circulating concentrations of insulin-like growth factor 1 (IGF-I), along with IGF-I relative to IGF-binding proteins (IGFBP), are associated with an increased risk of cancer. In accord, regular exercise is linked with a lower risk of cancer. Purpose To assess the effects of a 16-week home-based strength training (HBST) program on serum IGF-I, IGFBP-1 and IGFBP-3. Methods A total of 32 obese Latino adolescent males (aged 14-18 years) were randomized into a twice-weekly HBST (n = 16) or a control group (C, n = 16) for 16 weeks. The following were measured at pre- and post-intervention: IGF-I, IGFBP-1 and IGFBP-3, glucose/insulin indices by oral and/or intravenous (IV) glucose tolerance tests, strength by one-repetition maximum (1RM), dietary intake by 3-d records, body composition by DEXA and physical activity using the Actigraph GT1X. The generalized linear model (GLM) was used to assess differences in changes among outcome measures between the HBST and C groups. Results Exercise adherence in the HBST group was 89%. IGF-1 showed a trend for significant within-subject improvements (p = 0.078) but no significant within-subject or between-subject differences for IGFBP-1, IGFBP-3 two-glucose, fasting glucose or 2-h glucose (p > 0.05). There was a significant decrease (p > 0.05) in fasting glucose in the C group (p = 0.02) and also in the intervention group (p = 0.03) between baseline and follow-up testing. A significant difference was also found in the C group for 2-h glucose with an increase at follow-up testing (p = 0.04). Conclusions Though not statistically significant (p < 0.05), the results indicated that a 16-week HBST program decreased IGF-I and increased IGFBP-1, along with IGFBP-3, concentrations among overweight/obese Latino boys. However, further studies should consider increasing either the dose or the duration of the intervention to elicit greater improvements in this at-risk pediatric population.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (IGF1 protein, human). 0 (IGFBP1 protein, human). 0 (IGFBP3 protein, human). 0 (Insulin-Like Growth Factor Binding Protein 1). 0 (Insulin-Like Growth Factor Binding Protein 3). 67763-96-6 (Insulin-Like Growth Factor I).
+Publication Type
+ Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fjpem-2019-0073
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kelly&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Effect+of+home-based+strength+training+program+on+IGF-I%2C+IGFBP-1+and+IGFBP-3+in+obese+Latino+boys+participating+in+a+16-week+randomized+controlled+trial.&volume=32&issue=10&spage=1121&epage=1129&date=2019&doi=10.1515%2Fjpem-2019-0073&pmid=31539362&sid=OVID:medline
+
+<2024>
+Unique Identifier
+ 31534560
+Title
+ Alanine Aminotransferase and Body Composition in Obese Men and Women.
+Source
+ Disease Markers. 2019:1695874, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bekkelund SI; Jorde R
+Author NameID
+ Bekkelund, Svein Ivar; ORCID: https://orcid.org/0000-0002-8464-7199
+ Jorde, Rolf; ORCID: https://orcid.org/0000-0002-8803-6408
+Authors Full Name
+ Bekkelund, Svein Ivar; Jorde, Rolf.
+Institution
+ Bekkelund, Svein Ivar. Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromso, Norway.
+ Bekkelund, Svein Ivar. Department of Neurology and Neurophysiology, University Hospital of North Norway, Tromso, Norway.
+ Jorde, Rolf. Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromso, Norway.
+ Jorde, Rolf. Division of Internal Medicine, University Hospital of North Norway, N-9037 Tromso, Norway.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Aged
+ *Alanine Transaminase/bl [Blood]
+ Biomarkers/bl [Blood]
+ Female
+ Humans
+ Male
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/dg [Diagnostic Imaging]
+ Randomized Controlled Trials as Topic
+Abstract
+ There is a known relationship between serum alanine aminotransferase (ALT) and obesity in humans, but the mechanism(s) are not clarified. This study investigated the associations between serum ALT and body composition in an overweight and obese population. The results are based on data from a previous randomized controlled trial treating obesity with vitamin D3. A sample of 448 overweight and obese individuals underwent dual-energy X-ray absorptiometry (DEXA) and measured serum ALT along with supplementary blood samples at study baseline. Body fat mass and lean mass indexes were calculated by dividing total body fat/lean weight (kg) by body height squared (kg/m2). ALT correlated with body mass index (BMI) in men but not women (r = 0.33, P < 0.0001 vs. r = 0.06, P = 0.29). In men, serum ALT correlated positively with fat mass index (r = 0.23, P = 0.004) and lean mass index (r = 0.32, P < 0.0001). In women, ALT correlated with lean mass index (r = 0.13, P = 0.031) but not fat mass index (r = 0.003, P = 0.96). In a multivariate model adjusted for age and fat mass index, a 1-unit increase in lean mass index associated with a 0.37 U/L higher ALT in the male subgroup (95% CI 0.024 to 0.040, P < 0.0001). In conclusion, serum ALT was associated with body fat mass index in men and with lean mass index in men and women in an overweight and obese population. The findings also demonstrate a gender difference in the role of fat.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 2-6-1-2 (Alanine Transaminase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1155%2f2019%2f1695874
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bekkelund&issn=0278-0240&title=Disease+Markers&atitle=Alanine+Aminotransferase+and+Body+Composition+in+Obese+Men+and+Women.&volume=2019&issue=&spage=1695874&epage=&date=2019&doi=10.1155%2F2019%2F1695874&pmid=31534560&sid=OVID:medline
+
+<2025>
+Unique Identifier
+ 31531602
+Title
+ Plasmatic adipocyte biomarkers and foot pain associated with flatfoot in schoolchildren with obesity.
+Source
+ Revista Da Associacao Medica Brasileira. 65(8):1061-1066, 2019 Sep 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Alghadir AH; Gabr SA; Rizk AA
+Author NameID
+ Alghadir, Ahmad H; ORCID: http://orcid.org/0000-0003-1557-4165
+ Gabr, Sami A; ORCID: http://orcid.org/0000-0001-5071-291X
+ Rizk, Ashraf A; ORCID: http://orcid.org/0000-0002-1587-3221
+Authors Full Name
+ Alghadir, Ahmad H; Gabr, Sami A; Rizk, Ashraf A.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ *Adipocytes/ch [Chemistry]
+ Adiponectin/bl [Blood]
+ *Biomarkers/bl [Blood]
+ Body Mass Index
+ Child
+ Cohort Studies
+ Cross-Sectional Studies
+ Enzyme-Linked Immunosorbent Assay
+ Female
+ *Flatfoot/bl [Blood]
+ Flatfoot/co [Complications]
+ Humans
+ Interleukin-6/bl [Blood]
+ Leptin/bl [Blood]
+ Male
+ *Obesity/bl [Blood]
+ Obesity/co [Complications]
+ *Pain/bl [Blood]
+ Pain/et [Etiology]
+ Pain Measurement
+ Resistin/bl [Blood]
+ Severity of Illness Index
+ Tumor Necrosis Factor-alpha/bl [Blood]
+Abstract
+ OBJECTIVE: The aim of this study was to determine the potential association of foot pain and plasmatic adipocytes as physiological biomarkers of childhood obesity with the incidence of flatfoot in a cohort of Egyptian school children aged 6 -12 years.
+
+ METHODS: A total of 550 Egyptian schoolchildren (220 boys and 330 girls) aged 6-12 years were randomly invited to participate in this descriptive survey analysis. For all children, we assessed the diagnosis and severity of flatfoot as well as plasma adipocytes, as well as adiponectin, leptin, resistin, IL-6, and TNF-alpha, using the Dennis method and immunoassay techniques respectively. Foot pain was assessed by using a standard VAS of 100 mm and Faces Pain Scale, respectively.
+
+ RESULTS: Flat foot was predicted in 30.4% of school-age children, most of them showed a higher frequency of overweight (33.3%) and obesity (62.5%). Boys showed higher ranges of flat foot than girls. Foot pain significantly correlated with flat foot and obesity among the studied populations. In overweight-obese children, plasmatic adipocyte variables, as well as adiponectin, leptin, resistin, IL-6, TNF-alpha showed significant correlations with foot stance, especially in boys. Also, the studied adipocyte variables along with BMI, age, gender explained about~65% of the variance of flatfoot with pain among our school-age students.
+
+ CONCLUSION: Foot pain showed an association with flat foot and childhood obesity in 30.4% of school-age students (6-12 years). Foot pain was shown to correlate positively with the incidence of flat foot and changes in adiposity markers, as well as adiponectin, leptin, resistin, Il-6, TNF-alpha.
+Registry Number/Name of Substance
+ 0 (Adiponectin). 0 (Biomarkers). 0 (Interleukin-6). 0 (Leptin). 0 (Resistin). 0 (Tumor Necrosis Factor-alpha).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1590%2f1806-9282.65.8.1061
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Alghadir&issn=0104-4230&title=Revista+Da+Associacao+Medica+Brasileira&atitle=Plasmatic+adipocyte+biomarkers+and+foot+pain+associated+with+flatfoot+in+schoolchildren+with+obesity.&volume=65&issue=8&spage=1061&epage=1066&date=2019&doi=10.1590%2F1806-9282.65.8.1061&pmid=31531602&sid=OVID:medline
+
+<2026>
+Unique Identifier
+ 31530820
+Title
+ Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
+Source
+ Scientific Reports. 9(1):13424, 2019 09 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zeng Q; Li D; He Y; Li Y; Yang Z; Zhao X; Liu Y; Wang Y; Sun J; Feng X; Wang F; Chen J; Zheng Y; Yang Y; Sun X; Xu X; Wang D; Kenney T; Jiang Y; Gu H; Li Y; Zhou K; Li S; Dai W
+Authors Full Name
+ Zeng, Qiang; Li, Dongfang; He, Yuan; Li, Yinhu; Yang, Zhenyu; Zhao, Xiaolan; Liu, Yanhong; Wang, Yu; Sun, Jing; Feng, Xin; Wang, Fei; Chen, Jiaxing; Zheng, Yuejie; Yang, Yonghong; Sun, Xuelin; Xu, Ximing; Wang, Daxi; Kenney, Toby; Jiang, Yiqi; Gu, Hong; Li, Yongli; Zhou, Ke; Li, Shuaicheng; Dai, Wenkui.
+Institution
+ Zeng, Qiang. Health management institute, People's Liberation Army General Hospital, Beijing, China.
+ Li, Dongfang. Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
+ Li, Dongfang. Department of Microbial Research, WeHealthGene Institute, Shenzhen, Guangdong Province, China.
+ Li, Dongfang. Joint Laboratory of Micro-ecology and Children's Health, Shenzhen Children's Hospital & Shenzhen WeHealthGene Co. Ltd., Shenzhen, Guangdong Province, China.
+ He, Yuan. National Research Institute for Health, Beijing, China.
+ Li, Yinhu. Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong, China.
+ Yang, Zhenyu. School of Statistics and Data Science, Nankai University, Tianjin, China.
+ Zhao, Xiaolan. Southwest Hospital of Third Military Medical University, Chongqing, China.
+ Liu, Yanhong. Department of Microbial Research, WeHealthGene Institute, Shenzhen, Guangdong Province, China.
+ Liu, Yanhong. Joint Laboratory of Micro-ecology and Children's Health, Shenzhen Children's Hospital & Shenzhen WeHealthGene Co. Ltd., Shenzhen, Guangdong Province, China.
+ Wang, Yu. Health management center, The 910th Hospital of People's Liberation Army, Quanzhou, Fujian Province, China.
+ Sun, Jing. The China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
+ Feng, Xin. Department of Microbial Research, WeHealthGene Institute, Shenzhen, Guangdong Province, China.
+ Feng, Xin. Joint Laboratory of Micro-ecology and Children's Health, Shenzhen Children's Hospital & Shenzhen WeHealthGene Co. Ltd., Shenzhen, Guangdong Province, China.
+ Wang, Fei. Health management institute, People's Liberation Army General Hospital, Beijing, China.
+ Chen, Jiaxing. Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong, China.
+ Zheng, Yuejie. Joint Laboratory of Micro-ecology and Children's Health, Shenzhen Children's Hospital & Shenzhen WeHealthGene Co. Ltd., Shenzhen, Guangdong Province, China.
+ Zheng, Yuejie. Department of Respiratory, Shenzhen Children's Hospital, Shenzhen, Guangdong Province, China.
+ Yang, Yonghong. Joint Laboratory of Micro-ecology and Children's Health, Shenzhen Children's Hospital & Shenzhen WeHealthGene Co. Ltd., Shenzhen, Guangdong Province, China.
+ Yang, Yonghong. Department of Respiratory, Shenzhen Children's Hospital, Shenzhen, Guangdong Province, China.
+ Sun, Xuelin. Department of Cardiology, Longkou People's Hospital, Longkou, Shandong Province, China.
+ Xu, Ximing. School of Statistics and Data Science, Nankai University, Tianjin, China.
+ Wang, Daxi. Department of Microbial Research, WeHealthGene Institute, Shenzhen, Guangdong Province, China.
+ Wang, Daxi. Joint Laboratory of Micro-ecology and Children's Health, Shenzhen Children's Hospital & Shenzhen WeHealthGene Co. Ltd., Shenzhen, Guangdong Province, China.
+ Kenney, Toby. Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, Canada.
+ Jiang, Yiqi. Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong, China.
+ Gu, Hong. Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, Canada.
+ Li, Yongli. Department of Health Management, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.
+ Zhou, Ke. Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. k.zhou@hust.edu.cn.
+ Li, Shuaicheng. Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong, China. shuaicli@cityu.edu.hk.
+ Dai, Wenkui. Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong, China. wenkuidai2-c@my.cityu.edu.hk.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Mass Index
+ Feces/mi [Microbiology]
+ Female
+ *Gastrointestinal Microbiome/ph [Physiology]
+ Humans
+ Male
+ Middle Aged
+ *Obesity/me [Metabolism]
+ *Obesity/mi [Microbiology]
+Abstract
+ The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM markers for obesity in patients with different metabolic abnormalities and investigate their relationships with clinical indicators, 1,914 Chinese adults were enrolled for 16S rRNA gene sequencing in this retrospective study. Based on GM composition, Random forest classifiers were constructed to screen the obesity patients with (Group OA) or without metabolic diseases (Group O) from healthy individuals (Group H), and high accuracies were observed for the discrimination of Group O and Group OA (areas under the receiver operating curve (AUC) equal to 0.68 and 0.76, respectively). Furthermore, six GM markers were shared by obesity patients with various metabolic disorders (Bacteroides, Parabacteroides, Blautia, Alistipes, Romboutsia and Roseburia). As for the discrimination with Group O, Group OA exhibited low accuracy (AUC = 0.57). Nonetheless, GM classifications to distinguish between Group O and the obese patients with specific metabolic abnormalities were not accurate (AUC values from 0.59 to 0.66). Common biomarkers were identified for the obesity patients with high uric acid, high serum lipids and high blood pressure, such as Clostridium XIVa, Bacteroides and Roseburia. A total of 20 genera were associated with multiple significant clinical indicators. For example, Blautia, Romboutsia, Ruminococcus2, Clostridium sensu stricto and Dorea were positively correlated with indicators of bodyweight (including waistline and body mass index) and serum lipids (including low density lipoprotein, triglyceride and total cholesterol). In contrast, the aforementioned clinical indicators were negatively associated with Bacteroides, Roseburia, Butyricicoccus, Alistipes, Parasutterella, Parabacteroides and Clostridium IV. Generally, these biomarkers hold the potential to predict obesity-related metabolic abnormalities, and interventions based on these biomarkers might be beneficial to weight loss and metabolic risk improvement.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-49462-w
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zeng&issn=2045-2322&title=Scientific+Reports&atitle=Discrepant+gut+microbiota+markers+for+the+classification+of+obesity-related+metabolic+abnormalities.&volume=9&issue=1&spage=13424&epage=&date=2019&doi=10.1038%2Fs41598-019-49462-w&pmid=31530820&sid=OVID:medline
+
+<2027>
+Unique Identifier
+ 31527400
+Title
+ Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet?.
+Source
+ Nutrients. 11(9), 2019 Sep 16.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Muscogiuri G; Barrea L; Laudisio D; Di Somma C; Pugliese G; Salzano C; Colao A; Savastano S
+Author NameID
+ Barrea, Luigi; ORCID: https://orcid.org/0000-0001-9054-456X
+ Savastano, Silvia; ORCID: https://orcid.org/0000-0002-3211-4307
+Authors Full Name
+ Muscogiuri, Giovanna; Barrea, Luigi; Laudisio, Daniela; Di Somma, Carolina; Pugliese, Gabriella; Salzano, Ciro; Colao, Annamaria; Savastano, Silvia.
+Institution
+ Muscogiuri, Giovanna. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, via Sergio Pansini 5, 80131 Naples, Italy. giovanna.muscogiuri@gmail.com.
+ Barrea, Luigi. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, via Sergio Pansini 5, 80131 Naples, Italy. luigi.barrea@unina.it.
+ Laudisio, Daniela. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, via Sergio Pansini 5, 80131 Naples, Italy. dani.lauidisio@libero.it.
+ Di Somma, Carolina. IRCCS SDN, via Gianturco 113, 80143 Naples, Italy. cdisomma@unina.it.
+ Pugliese, Gabriella. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, via Sergio Pansini 5, 80131 Naples, Italy. robiniapugliese@gmail.com.
+ Salzano, Ciro. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, via Sergio Pansini 5, 80131 Naples, Italy. cirosalzano89@gmail.com.
+ Colao, Annamaria. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, via Sergio Pansini 5, 80131 Naples, Italy. colao@unina.it.
+ Savastano, Silvia. Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, via Sergio Pansini 5, 80131 Naples, Italy. sisavast@unina.it.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ *Diet, Mediterranean
+ *Dietary Proteins/ad [Administration & Dosage]
+ Dietary Proteins/me [Metabolism]
+ Energy Intake
+ *Energy Metabolism
+ Female
+ *Human Growth Hormone/bl [Blood]
+ Humans
+ Insulin Resistance
+ *Insulin-Like Growth Factor I/me [Metabolism]
+ Middle Aged
+ Nutritional Status
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/dh [Diet Therapy]
+ Obesity/pp [Physiopathology]
+ Patient Compliance
+ Time Factors
+ Treatment Outcome
+Keyword Heading
+ GH deficiency
+ IGF-1
+ Mediterranean diet
+ insulin resistance
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels-which in turn is associated with increased prevalence of cardiovascular risk factors. The aim of this study was to investigate: (1) the association of somatotropic axis with cardiometabolic status; (2) the association of somatotropic axis with the Mediterranean diet and nutritional pattern in people with obesity. Cross-sectional observational study was carried out in 200 adult women, aged 36.98 +/- 11.10 years with severe obesity (body mass index-BMI of 45.19 +/- 6.30 kg/m2). The adherence to the Mediterranean diet and the total calorie intake was assessed. Anthropometric measurements, body composition and biochemical profile were determined along with Growth Hormone (GH)/Insulin like Growth Factor 1 (IGF-1) axis and insulin resistance (homeostatic model assessment for insulin resistance-HoMA-IR). The enrolled subjects were compared after being divided according to GH peak response and according to IGF-1 standard deviation scores (SDS). Derangements of GH peak were detected in 61.5% of studied patients while IGF-1 deficiency was detected in 71% of the population. Both blunted GH peak response and IGF-1 SDS were indicators of derangements of somatotropic axis and were associated with comparable results in terms of cardiometabolic sequelae. Both GH peak and IGF-1 levels were inversely associated with anthropometric and metabolic parameters. The adherence to the Mediterranean diet predicts GH peak response. Fatty liver index (FLI), fat mass (FM) and phase angle (PhA) were predictive factors of GH peak response as well. In conclusion derangements of somatotropic axis is associated with a worse cardiometabolic profile in people with obesity. A high adherence to the Mediterranean diet-and in particular protein intake-was associated with a better GH status.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Dietary Proteins). 0 (IGF1 protein, human). 12629-01-5 (Human Growth Hormone). 67763-96-6 (Insulin-Like Growth Factor I).
+Publication Type
+ Journal Article. Observational Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11092228
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Muscogiuri&issn=2072-6643&title=Nutrients&atitle=Somatotropic+Axis+and+Obesity%3A+Is+There+Any+Role+for+the+Mediterranean+Diet%3F.&volume=11&issue=9&spage=&epage=&date=2019&doi=10.3390%2Fnu11092228&pmid=31527400&sid=OVID:medline
+
+<2028>
+Unique Identifier
+ 31522448
+Title
+ Histologic, Metabolic, and Inflammatory Changes in the Liver of High-fat Diet-induced Obese Rats before and after Vitamin D Administration.
+Source
+ Iranian Journal of Allergy Asthma & Immunology. 18(4):402-411, 2019 Aug 17.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yaghchiyan M; Roshangar L; Farhangi MA; Mesgari-Abbasi M; Rafiei L; Shahabi P
+Authors Full Name
+ Yaghchiyan, Mahdi; Roshangar, Leila; Farhangi, Mahdieh Abbasalizad; Mesgari-Abbasi, Mehran; Rafiei, Leila; Shahabi, Parviz.
+Institution
+ Yaghchiyan, Mahdi. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. abbasalizad_m@yahoo.com.
+ Roshangar, Leila. Stem Cells Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. abbasalizad_m@yahoo.com.
+ Farhangi, Mahdieh Abbasalizad. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. abbasalizad_m@yahoo.com.
+ Mesgari-Abbasi, Mehran. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. abbasalizad_m@yahoo.com.
+ Rafiei, Leila. Department of Food Sciences and Technology, University of Urmia, Urmia, Iran. abbasalizad_m@yahoo.com.
+ Shahabi, Parviz. Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. abbasalizad_m@yahoo.com.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ Biopsy
+ *Diet, High-Fat/ae [Adverse Effects]
+ Disease Models, Animal
+ Energy Metabolism/de [Drug Effects]
+ *Energy Metabolism
+ Inflammation/et [Etiology]
+ Inflammation/me [Metabolism]
+ Inflammation/pa [Pathology]
+ Liver/de [Drug Effects]
+ *Liver/me [Metabolism]
+ *Liver/pa [Pathology]
+ Liver Function Tests
+ Male
+ Obesity/dt [Drug Therapy]
+ *Obesity/et [Etiology]
+ *Obesity/me [Metabolism]
+ Obesity/pa [Pathology]
+ Rats
+ Vitamin D/ad [Administration & Dosage]
+ *Vitamin D/me [Metabolism]
+Keyword Heading
+ Inflammation
+ Liver histology
+ Obesity
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The current study aimed to investigate the effects of vitamin D administration on the markers of inflammation and metabolic damages in the liver of high-fat diet-induced obese rats. Forty male Wistar rats were divided into two groups of control receiving a normal diet (ND) and intervention receiving a high-fat diet (HFD). After 16 weeks, each group was divided into two groups including ND, ND + vitamin D, HFD, and HFD + vitamin D. Vitamin D was administered by oral gavage for five weeks at the dose of 500 IU/kg. Hepatic MCP-1, TGF-beta, and NF-kappaB levels, serum liver enzymes, and serum lipids, and histological and structural changes in the liver were determined. Vitamin D administration significantly reduced the monocyte chemoattractant protein (MCP)-1 concentrations in the HFD + vitamin D group compared with the HFD group and reduced liver Transforming growth factor beta (TGF-beta) levels in both vitamin D-treated groups (p<0.05). Moreover, a significant reduction in the serum levels of aspartate amino transferase (AST) and alanine amino transferase (ALT) in vitamin D treated groups was identified (p<0.05). A significant improvement in lipids and a pronounced improvement in the markers of liver histology damage including fat accumulation, aggregation of inflammatory cells, pre-apoptotic changes, hepatic sinusoidal dilatation, and necrotic pyknosis in the Kupffer cells were also identified. Our results demonstrated that vitamin D has potential effects in ameliorating the inflammatory, metabolic, and histologic changes in the liver of these animals.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.18502%2fijaai.v18i4.1418
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yaghchiyan&issn=1735-1502&title=Iranian+Journal+of+Allergy+Asthma+%26+Immunology&atitle=Histologic%2C+Metabolic%2C+and+Inflammatory+Changes+in+the+Liver+of+High-fat+Diet-induced+Obese+Rats+before+and+after+Vitamin+D+Administration.&volume=18&issue=4&spage=402&epage=411&date=2019&doi=10.18502%2Fijaai.v18i4.1418&pmid=31522448&sid=OVID:medline
+
+<2029>
+Unique Identifier
+ 31514469
+Title
+ Obesity Status Affects the Relationship Between Protein Intake and Insulin Sensitivity in Late Pregnancy.
+Source
+ Nutrients. 11(9), 2019 Sep 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Allman BR; Diaz Fuentes E; Williams DK; Turner DE; Andres A; Borsheim E
+Authors Full Name
+ Allman, Brittany R; Diaz Fuentes, Eva; Williams, D Keith; Turner, Donald E; Andres, Aline; Borsheim, Elisabet.
+Institution
+ Allman, Brittany R. Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA. ballman@uams.edu.
+ Allman, Brittany R. Arkansas Children's Research Institute, Little Rock, AR 72202, USA. ballman@uams.edu.
+ Allman, Brittany R. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. ballman@uams.edu.
+ Diaz Fuentes, Eva. Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA. ediazfuentes@uams.edu.
+ Diaz Fuentes, Eva. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. ediazfuentes@uams.edu.
+ Williams, D Keith. Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA. williamsdavidk@uams.edu.
+ Williams, D Keith. Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. williamsdavidk@uams.edu.
+ Turner, Donald E. Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA. turnerde@archildrens.org.
+ Andres, Aline. Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA. andresaline@uams.edu.
+ Andres, Aline. Arkansas Children's Research Institute, Little Rock, AR 72202, USA. andresaline@uams.edu.
+ Andres, Aline. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. andresaline@uams.edu.
+ Borsheim, Elisabet. Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA. eborsheim@uams.edu.
+ Borsheim, Elisabet. Arkansas Children's Research Institute, Little Rock, AR 72202, USA. eborsheim@uams.edu.
+ Borsheim, Elisabet. Department of Geriatrics, University of Arkansas for Medical Sciences,, Little Rock, AR 72205, USA. eborsheim@uams.edu.
+MeSH Subject Headings
+ Adult
+ Animal Proteins, Dietary/ad [Administration & Dosage]
+ Animal Proteins, Dietary/me [Metabolism]
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ Body Mass Index
+ Case-Control Studies
+ *Diabetes, Gestational/bl [Blood]
+ Diabetes, Gestational/di [Diagnosis]
+ Diabetes, Gestational/pp [Physiopathology]
+ *Dietary Proteins/ad [Administration & Dosage]
+ Dietary Proteins/me [Metabolism]
+ Female
+ Gestational Age
+ Humans
+ *Insulin/bl [Blood]
+ *Insulin Resistance
+ *Maternal Nutritional Physiological Phenomena
+ Models, Biological
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ Plant Proteins, Dietary/ad [Administration & Dosage]
+ Plant Proteins, Dietary/me [Metabolism]
+ Pregnancy
+ Risk Factors
+Keyword Heading
+ animal protein
+ glucose
+ insulin resistance
+ insulin sensitivity
+ obesity
+ plant protein
+ pregnancy
+ protein
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The purpose of this study was to determine the associations between amount and type of dietary protein intake and insulin sensitivity in late pregnancy, in normal weight and overweight women (29.8 +/- 0.2 weeks gestation, n = 173). A 100-gram oral glucose tolerance test (OGTT) was administered following an overnight fast to estimate the metabolic clearance rate of glucose (MCR, mg . kg-1 . min-1) using four different equations accounting for the availability of blood samples. Total (TP), animal (AP), and plant (PP) protein intakes were assessed using a 3-day food record. Two linear models with MCR as the response variable were fitted to the data to estimate the relationship of protein intake to insulin sensitivity either unadjusted or adjusted for early pregnancy body mass index (BMI) because of the potential of BMI to influence this relationship. There was a positive association between TP (beta = 1.37, p = 0.002) and PP (beta = 4.44, p < 0.001) intake in the last trimester of pregnancy and insulin sensitivity that weakened when accounting for early pregnancy BMI. However, there was no relationship between AP intake and insulin sensitivity (beta = 0.95, p = 0.08). Therefore, early pregnancy BMI may be a better predictor of insulin sensitivity than dietary protein intake in late pregnancy.
+Registry Number/Name of Substance
+ 0 (Animal Proteins, Dietary). 0 (Biomarkers). 0 (Blood Glucose). 0 (Dietary Proteins). 0 (Insulin). 0 (Plant Proteins, Dietary).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11092190
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Allman&issn=2072-6643&title=Nutrients&atitle=Obesity+Status+Affects+the+Relationship+Between+Protein+Intake+and+Insulin+Sensitivity+in+Late+Pregnancy.&volume=11&issue=9&spage=&epage=&date=2019&doi=10.3390%2Fnu11092190&pmid=31514469&sid=OVID:medline
+
+<2030>
+Unique Identifier
+ 31514294
+Title
+ Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice.
+Source
+ Nutrients. 11(9), 2019 Sep 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Song J; Kim YS; Kim L; Park HJ; Lee D; Kim H
+Author NameID
+ Song, Jungbin; ORCID: https://orcid.org/0000-0002-3587-9276
+ Lee, Donghun; ORCID: https://orcid.org/0000-0003-1075-0713
+Authors Full Name
+ Song, Jungbin; Kim, Young-Sik; Kim, Linae; Park, Hyo Jin; Lee, Donghun; Kim, Hocheol.
+Institution
+ Song, Jungbin. Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. jbsong@khu.ac.kr.
+ Kim, Young-Sik. Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. yjbsik@gmail.com.
+ Kim, Linae. Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. syusran@hanmail.net.
+ Park, Hyo Jin. Korea Institute of Science and Technology for Eastern Medicine (KISTEM), NeuMed Inc., 88 Imun-ro, Dongdaemun-gu, Seoul 02440, Korea. rnfyddyd@neumed.co.kr.
+ Lee, Donghun. Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si, Gyeonggi-do 13120, Korea. dlee@gachon.ac.kr.
+ Kim, Hocheol. Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. hckim@khu.ac.kr.
+MeSH Subject Headings
+ Animals
+ Anti-Obesity Agents/ip [Isolation & Purification]
+ *Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers/bl [Blood]
+ Diet, High-Fat
+ Disease Models, Animal
+ Eating
+ *Fatty Acids/me [Metabolism]
+ *Flowers/ch [Chemistry]
+ Gene Expression Regulation
+ *Lipogenesis/de [Drug Effects]
+ Lipogenesis/ge [Genetics]
+ *Liver/de [Drug Effects]
+ Liver/en [Enzymology]
+ Male
+ Mice, Inbred C57BL
+ Obesity/bl [Blood]
+ Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ *Obesity/pc [Prevention & Control]
+ Organ Size
+ Oxidation-Reduction
+ Plant Extracts/ip [Isolation & Purification]
+ *Plant Extracts/pd [Pharmacology]
+ *Prunus persica/ch [Chemistry]
+ *Weight Loss/de [Drug Effects]
+Keyword Heading
+ Prunus persica
+ anti-obesity
+ glucose
+ high-fat diet
+ lipogenesis
+ liver
+ peach blossom
+ beta-oxidation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Prunus persica (L.) Batsch is a deciduous fruit tree cultivated worldwide. The flower of P. persica (PPF), commonly called the peach blossom, is currently consumed as a tea for weight loss in East Asia; however, its anti-obesity effects have yet to be demonstrated in vitro or in vivo. Since PPF is rich in phytochemicals with anti-obesity properties, we aimed to investigate the effects of PPF on obesity and its underlying mechanism using a diet-induced obesity model. Male C57BL/6 mice were fed either normal diet, high-fat diet (HFD), or HFD containing 0.2% or 0.6% PPF water extract for 8 weeks. PPF significantly reduced body weight, abdominal fat mass, serum glucose, alanine transaminase and aspartate aminotransferase levels, and liver and spleen weights compared to the HFD control group. Real-time quantitative polymerase chain reaction analysis revealed that PPF suppressed lipogenic gene expression, including stearoyl-CoA desaturase-1 and -2 and fatty acid synthase, and up-regulated the fatty acid beta-oxidation gene, carnitine palmitoyltransferase-1, in the liver. Our results suggest that PPF exerts anti-obesity effects in obese mice and these beneficial effects might be mediated through improved hepatic lipid metabolism by reducing lipogenesis and increasing fatty acid oxidation.
+Registry Number/Name of Substance
+ 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Fatty Acids). 0 (Plant Extracts).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11092176
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Song&issn=2072-6643&title=Nutrients&atitle=Anti-Obesity+Effects+of+the+Flower+of+Prunus+persica+in+High-Fat+Diet-Induced+Obese+Mice.&volume=11&issue=9&spage=&epage=&date=2019&doi=10.3390%2Fnu11092176&pmid=31514294&sid=OVID:medline
+
+<2031>
+Unique Identifier
+ 31509979
+Title
+ Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice-Effects on Blood Glucose and Insulin Levels on Healthy Subjects.
+Source
+ Nutrients. 11(9), 2019 Sep 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Papandreou D; Magriplis E; Abboud M; Taha Z; Karavolia E; Karavolias C; Zampelas A
+Author NameID
+ Magriplis, Emmanouella; ORCID: https://orcid.org/0000-0001-6517-6857
+Authors Full Name
+ Papandreou, Dimitrios; Magriplis, Emmanouella; Abboud, Myriam; Taha, Zainab; Karavolia, Eleftheria; Karavolias, Christos; Zampelas, Antonis.
+Institution
+ Papandreou, Dimitrios. Department of Health Sciences, CNHS, Zayed University, Abu Dhabi 144534, UAE. Dimitrios.papandreou@zu.ac.ae.
+ Magriplis, Emmanouella. Department of Food Science and Human Nutrition, Agriculture University of Athens, 11855 Athens, Greece. emagriplis@eatsmart.gr.
+ Abboud, Myriam. Department of Health Sciences, CNHS, Zayed University, Abu Dhabi 144534, UAE. Myriam.abboud@zu.ac.ae.
+ Taha, Zainab. Department of Health Sciences, CNHS, Zayed University, Abu Dhabi 144534, UAE. Zainab.taha@zu.ac.ae.
+ Karavolia, Eleftheria. Faculty of Medicine, University of Groningen, 9712KB Groningen, The Netherlands. elka19@hotmail.com.
+ Karavolias, Christos. Doctor's Medical Center, Abu Dhabi, Abu Dhabi 46400, UAE. karavolias@hotmail.com.
+ Zampelas, Antonis. Department of Food Science and Human Nutrition, Agriculture University of Athens, 11855 Athens, Greece. azampelas@aua.gr.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ *Blood Glucose/me [Metabolism]
+ *Citrus sinensis/me [Metabolism]
+ Cross-Over Studies
+ Female
+ *Fruit/me [Metabolism]
+ *Fruit and Vegetable Juices
+ Healthy Volunteers
+ Humans
+ *Insulin/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Plant Nectar/ad [Administration & Dosage]
+ *Plant Nectar/me [Metabolism]
+ *Postprandial Period
+ Prospective Studies
+ *Sugar-Sweetened Beverages
+ Time Factors
+ Young Adult
+Keyword Heading
+ Emirati
+ diabetes type 2
+ glucose
+ insulin
+ orange juice
+ raw orange
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The aim of this study is to investigate the effect of consumption of raw orange (RO), 100% fresh orange juice (FOJ), and nectar-sweetened orange juice (NSOJ) on postprandial glucose and insulin levels in non-diabetic young Emirati women.
+
+ RESEARCH METHODS: This is a prospective, three-way, crossover study design. Blood records of thirteen normal weight and seven healthy obese university students were analyzed from Zayed University on three random days with the following three meal samples: 2 ROs, 100% FOJ, and NSOJ. Venous blood was collected at 0, 30, 60, 90, and 120 minutes after the respective meal consumption. Statistical analyses included repeated measures analysis of variance and calculations of the area under the glucose and insulin curves (AUC) for each one of the meal samples.
+
+ RESULTS: Total fasting glucose and insulin levels did not differ by treatment in the normal versus obese group. All three meals had no significant effects on the plasma glucose levels. However, there was a significant change in plasma insulin concentrations at 120 min compared with that at 0 min for RO: -14 (-27.05, -0.90, P < 0.001); 100% FOJ -13.7 (-28.80, 1.44, P < 0.001); and NSOJ: -9.2 (-28.75, 10.30, P < 0.001).
+
+ CONCLUSIONS: This study shows that whole fresh fruit, 100% fruit juice, and sweetened fruit juice did not have a significant effect on the blood glucose levels in non-diabetic Emirati university students. However, a significant decrease in insulin response and HOMA-IR on all three sample meals was observed.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 0 (Plant Nectar).
+Publication Type
+ Comparative Study. Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11092171
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Papandreou&issn=2072-6643&title=Nutrients&atitle=Consumption+of+Raw+Orange%2C+100%25+Fresh+Orange+Juice%2C+and+Nectar-+Sweetened+Orange+Juice-Effects+on+Blood+Glucose+and+Insulin+Levels+on+Healthy+Subjects.&volume=11&issue=9&spage=&epage=&date=2019&doi=10.3390%2Fnu11092171&pmid=31509979&sid=OVID:medline
+
+<2032>
+Unique Identifier
+ 31509577
+Title
+ Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women.
+Source
+ PLoS ONE [Electronic Resource]. 14(9):e0222239, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Galvao-Moreira LV; Nascimento ACB; D'Albuquerque IMSC; Sousa MAS; Brito HO; Nascimento MDDSB; da Costa Chein MB; Brito LMO
+Author NameID
+ Galvao-Moreira, Leonardo Victor; ORCID: https://orcid.org/0000-0003-4913-8783
+Authors Full Name
+ Galvao-Moreira, Leonardo Victor; Nascimento, Anna Cyntia Brandao; D'Albuquerque, Izabella Mikaella Souza Campos; Sousa, Marcus Antonio Silva; Brito, Haissa Oliveira; Nascimento, Maria do Desterro Soares Brandao; da Costa Chein, Maria Bethania; Brito, Luciane Maria Oliveira.
+Institution
+ Galvao-Moreira, Leonardo Victor. School of Medicine, Federal University of Maranhao, Sao Luis, Brazil.
+ Nascimento, Anna Cyntia Brandao. Postgraduate Program in Adult Health, Federal University of Maranhao, Sao Luis, Brazil.
+ D'Albuquerque, Izabella Mikaella Souza Campos. School of Medicine, Federal University of Maranhao, Sao Luis, Brazil.
+ Sousa, Marcus Antonio Silva. School of Medicine, Federal University of Maranhao, Sao Luis, Brazil.
+ Brito, Haissa Oliveira. Postgraduate Program in Adult Health, Federal University of Maranhao, Sao Luis, Brazil.
+ Nascimento, Maria do Desterro Soares Brandao. Postgraduate Program in Adult Health, Federal University of Maranhao, Sao Luis, Brazil.
+ da Costa Chein, Maria Bethania. Postgraduate Program in Adult Health, Federal University of Maranhao, Sao Luis, Brazil.
+ Brito, Luciane Maria Oliveira. Postgraduate Program in Adult Health, Federal University of Maranhao, Sao Luis, Brazil.
+MeSH Subject Headings
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Brazil/ep [Epidemiology]
+ C-Reactive Protein/an [Analysis]
+ Cross-Sectional Studies
+ Female
+ Gonadal Steroid Hormones/an [Analysis]
+ Gonadal Steroid Hormones/bl [Blood]
+ Gonadotropins/an [Analysis]
+ Gonadotropins/bl [Blood]
+ Humans
+ Interleukin-6/an [Analysis]
+ Interleukin-6/bl [Blood]
+ Leptin/an [Analysis]
+ Leptin/bl [Blood]
+ Lipids/an [Analysis]
+ Lipids/bl [Blood]
+ Menopause/bl [Blood]
+ *Menopause/me [Metabolism]
+ Middle Aged
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Postmenopause/bl [Blood]
+ Premenopause/bl [Blood]
+Abstract
+ AIM: To investigate circulating hormonal, metabolic and inflammatory biomarker profiles in obese and non-obese middle-aged women.
+
+ METHODS: A total of 110 women, aged 40-60 years, were included in this cross-sectional study. Patients were allocated, according to the occurrence of menopause and body mass index (BMI), into four groups: PM0 (premenopausal non-obese), PM1 (premenopausal obese), M0 (postmenopausal non-obese), and M1 (postmenopausal obese). Serum levels of gonadotropins, sex hormones, lipid markers, leptin, hs-CRP and interleukin-6 were obtained using either colorimetric or immunoenzymatic assays. Univariate and correlation analyses were performed among all clinical and laboratorial parameters. Principal component analysis was used to characterize subsets of biomarkers, which had their discriminatory capacity tested using discriminant function analysis.
+
+ RESULTS: Levels of gonadotropins and female sex hormones were similar between PM0 and PM1 and between M0 and M1 (p > 0.05), all of them varied between PM0 and M0 (p < 0.05), but only estradiol was significantly altered in the comparison between PM1 and M1 (p = 0.027). Regarding metabolic markers, leptin was lower in PM0 than in M0 (p = 0.010) and higher in M1 than in M0 (p = 0.046). In premenopausal women, BMI correlated only to leptin, while it correlated to several other markers in postmenopausal women. A combination of FSH and leptin serum levels significantly discriminated the four groups (Wilks's lambda < 0.001, in canonical functions 1 and 2).
+
+ CONCLUSION: A combined analysis of hormonal biomarkers may potentially distinguish obese from non-obese women with distinct menopause status. Further research is thus required to clarify the clinical significance of such findings.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Gonadal Steroid Hormones). 0 (Gonadotropins). 0 (Interleukin-6). 0 (Leptin). 0 (Lipids). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0222239
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Galvao-Moreira&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Hormonal%2C+metabolic+and+inflammatory+circulating+biomarker+profiles+in+obese+and+non-obese+Brazilian+middle-aged+women.&volume=14&issue=9&spage=e0222239&epage=&date=2019&doi=10.1371%2Fjournal.pone.0222239&pmid=31509577&sid=OVID:medline
+
+<2033>
+Unique Identifier
+ 31509542
+Title
+ Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis.
+Source
+ PLoS ONE [Electronic Resource]. 14(9):e0221076, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xu X; Li W; Qin L; Yang W; Yu G; Wei Q
+Author NameID
+ Yu, Guowei; ORCID: https://orcid.org/0000-0002-0891-3029
+Authors Full Name
+ Xu, Xinlan; Li, Weide; Qin, Lan; Yang, Wenjiao; Yu, Guowei; Wei, Qishan.
+Institution
+ Xu, Xinlan. School of Mathematics and Statistics, Lanzhou University, Lanzhou, Gansu, China.
+ Li, Weide. School of Mathematics and Statistics, Lanzhou University, Lanzhou, Gansu, China.
+ Qin, Lan. School of Mathematics and Statistics, Lanzhou University, Lanzhou, Gansu, China.
+ Yang, Wenjiao. School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
+ Yu, Guowei. Medical College of Northwest University for Nationalities, Lanzhou, Gansu, China.
+ Wei, Qishan. Maternal and Child Health Hospital, Lanzhou, Gansu, China.
+MeSH Subject Headings
+ Adult
+ Age Factors
+ Aged
+ Biomarkers
+ Body Mass Index
+ China/ep [Epidemiology]
+ Cross-Sectional Studies
+ Databases, Factual
+ Female
+ *Helicobacter Infections/co [Complications]
+ *Helicobacter Infections/ep [Epidemiology]
+ Helicobacter Infections/mi [Microbiology]
+ *Helicobacter pylori
+ Humans
+ Male
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ *Obesity/et [Etiology]
+ Population Surveillance
+ Prevalence
+ Risk Factors
+Abstract
+ BACKGROUND: Obesity is highly prevalent worldwide. More and more studies have been conducted on the relationship between H. pylori infection and obesity or overweight. But the relationship between them is controversial in the literatures and there is no comprehensive evidence for the correlation.
+
+ AIM: To evaluate the prevalence of H. pylori infection in Chinese adult subjects who received routine physical examinations and the relationship between H. pylori and obesity.
+
+ METHODS: Literatures on H. pylori infection and obesity in Chinese population were searched in online databases. Relevant data were extracted independently by two researchers and meta-analysis was performed by using Review manager 5.3 software.
+
+ RESULTS: 22 articles were selected with a total sample size of 178033. The pooled prevalence of H. pylori was 42% (95%CI: 37% to 47%) and mean difference of BMI between subjects with and without H. pylori infection was 0.94 (95%CI: -0.04 to 1.91). 9 eligible studies with 27111 subjects were used to calculated pooled OR value because they contained obesity groups. The OR value showed that H. pylori-positive subjects tended to be obese at a risk of 1.20 (95% CI: 1.13 to 1.28).
+
+ CONCLUSION: In China, obesity has association with H. pylori infection. H. pylori infection may be one of the risk factors for obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0221076
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xu&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Relationship+between+Helicobacter+pylori+infection+and+obesity+in+Chinese+adults%3A+A+systematic+review+with+meta-analysis.&volume=14&issue=9&spage=e0221076&epage=&date=2019&doi=10.1371%2Fjournal.pone.0221076&pmid=31509542&sid=OVID:medline
+
+<2034>
+Unique Identifier
+ 31508889
+Title
+ Study of changes of obesity-related inflammatory cytokines after laparoscopic sleeve gastrectomy.
+Source
+ ANZ Journal of Surgery. 89(10):1265-1269, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Salman MA; Salman AA; Nafea MA; Sultan AAEA; Anwar HW; Ibrahim AH; Awad A; Ahmed RA; Seif El Nasr SM; Abouelregal TE; Shaaban HE; Mohamed FAH
+Authors Full Name
+ Salman, Mohamed Abdalla; Salman, Ahmed Abdallah; Nafea, Mohammed A; Sultan, Ahmed Abd El Aal; Anwar, Hisham W; Ibrahim, Ayman Helmy; Awad, Abeer; Ahmed, Reham Abdelghany; Seif El Nasr, Sayed M; Abouelregal, Tarek Elsayed; Shaaban, Hossam El-Din; Mohamed, Fatma Abdel Hamid.
+Institution
+ Salman, Mohamed Abdalla. General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Salman, Ahmed Abdallah. Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Nafea, Mohammed A. General Surgery Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.
+ Sultan, Ahmed Abd El Aal. General Surgery Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.
+ Anwar, Hisham W. General Surgery Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.
+ Ibrahim, Ayman Helmy. General Surgery Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.
+ Awad, Abeer. Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Ahmed, Reham Abdelghany. Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Seif El Nasr, Sayed M. Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Abouelregal, Tarek Elsayed. Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
+ Shaaban, Hossam El-Din. National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
+ Mohamed, Fatma Abdel Hamid. Tropical Medicine Department, El-Fayoum University, El Fayoum, Egypt.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Cytokines/bl [Blood]
+ Female
+ Follow-Up Studies
+ Gastrectomy/mt [Methods]
+ *Gastrectomy
+ Humans
+ *Inflammation/bl [Blood]
+ Inflammation/di [Diagnosis]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/su [Surgery]
+ Prospective Studies
+ Treatment Outcome
+ Weight Loss
+Keyword Heading
+ inflammatory cytokines
+ obesity
+ sleeve gastrectomy
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Chronic inflammation in adipose tissue may play a substantial role in the pathogenesis of obesity-related metabolic disorders. The present study aims to evaluate the changes in adipocytokines, bile acids, fibroblast growth factor 19 (FGF-19) and pro-inflammatory cytokines 6 months after laparoscopic sleeve gastrectomy (LSG).
+
+ METHODS: This prospective study included 75 obese patients with body mass index >35 kg/m2 who underwent LSG. All patients were recruited preoperatively and followed up post-operatively at 6 months, with laboratory assessment of their cytokines including adiponectin, leptin, resistin, bile acid, interleukin (IL)-6, IL-8, tumour necrosis factor-alpha, monocyte chemotactic protein-1, high-sensitivity C-reactive protein, plasminogen activator inhibitor-1, serum amyloid-A and FGF-19.
+
+ RESULTS: There were statistically highly significant changes regarding anthropometric parameters (weight, body mass index and waist-to-hip ratio), blood glucose and lipid profile as well as liver enzymes at 6 months post-sleeve gastrectomy. The present study showed that the levels of serum adiponectin and FGF-19 significantly increased at 6 months of follow-up after surgery (P < 0.001), while the levels of serum leptin, resistin, high-sensitivity C-reactive protein, plasminogen activator inhibitor-1 and serum amyloid-A significantly decreased at 6 months of follow-up after surgery (P < 0.001). There were no significant differences regarding serum bile acid, IL-6, IL-8, tumour necrosis factor-alpha and monocyte chemotactic protein-1.
+
+ CONCLUSION: Weight loss after LSG is associated with significant improvement of the adipokine levels towards anti-diabetic and anti-inflammatory profiles. Future studies should use a larger sample size and longer follow-up periods. Copyright © 2019 Royal Australasian College of Surgeons.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Clinical Trial. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1111%2fans.15427
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Salman&issn=1445-1433&title=ANZ+Journal+of+Surgery&atitle=Study+of+changes+of+obesity-related+inflammatory+cytokines+after+laparoscopic+sleeve+gastrectomy.&volume=89&issue=10&spage=1265&epage=1269&date=2019&doi=10.1111%2Fans.15427&pmid=31508889&sid=OVID:medline
+
+<2035>
+Unique Identifier
+ 31503497
+Title
+ Glycoprotein A and B Height-to-Width Ratios as Obesity-Independent Novel Biomarkers of Low-Grade Chronic Inflammation in Women with Polycystic Ovary Syndrome (PCOS).
+Source
+ Journal of Proteome Research. 18(11):4038-4045, 2019 11 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fuertes-Martin R; Moncayo S; Insenser M; Martinez-Garcia MA; Luque-Ramirez M; Grau NA; Blanchar XC; Escobar-Morreale HF
+Author NameID
+ Escobar-Morreale, Hector F; ORCID: https://orcid.org/0000-0002-6890-1644
+Authors Full Name
+ Fuertes-Martin, Rocio; Moncayo, Samuel; Insenser, Maria; Martinez-Garcia, M Angeles; Luque-Ramirez, Manuel; Grau, Nuria Amigo; Blanchar, Xavier Correig; Escobar-Morreale, Hector F.
+Institution
+ Fuertes-Martin, Rocio. 1Biosfer Teslab SL, DEEEA, 43007 Tarragona, Spain.
+ Fuertes-Martin, Rocio. Metabolomics platform, DEEEA-Universitat Rovira i Virgili, Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43204 Reus, Spain.
+ Moncayo, Samuel. Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), 28034 Madrid, Spain.
+ Moncayo, Samuel. Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), 28029 Madrid, Spain .
+ Insenser, Maria. Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), 28034 Madrid, Spain.
+ Insenser, Maria. Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), 28029 Madrid, Spain .
+ Martinez-Garcia, M Angeles. Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), 28034 Madrid, Spain.
+ Martinez-Garcia, M Angeles. Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), 28029 Madrid, Spain .
+ Luque-Ramirez, Manuel. Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), 28034 Madrid, Spain.
+ Luque-Ramirez, Manuel. Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), 28029 Madrid, Spain .
+ Grau, Nuria Amigo. 1Biosfer Teslab SL, DEEEA, 43007 Tarragona, Spain.
+ Blanchar, Xavier Correig. 1Biosfer Teslab SL, DEEEA, 43007 Tarragona, Spain.
+ Blanchar, Xavier Correig. Metabolomics platform, DEEEA-Universitat Rovira i Virgili, Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43204 Reus, Spain.
+ Blanchar, Xavier Correig. Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), 28029 Madrid, Spain .
+ Escobar-Morreale, Hector F. Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), 28034 Madrid, Spain.
+ Escobar-Morreale, Hector F. Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), 28029 Madrid, Spain .
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Biomarkers/me [Metabolism]
+ Chronic Disease
+ Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Glycoproteins/bl [Blood]
+ *Glycoproteins/me [Metabolism]
+ Humans
+ Inflammation/bl [Blood]
+ Inflammation/di [Diagnosis]
+ *Inflammation/me [Metabolism]
+ Male
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ Polycystic Ovary Syndrome/bl [Blood]
+ Polycystic Ovary Syndrome/di [Diagnosis]
+ *Polycystic Ovary Syndrome/me [Metabolism]
+ Proteomics/mt [Methods]
+ Proton Magnetic Resonance Spectroscopy/mt [Methods]
+ *Waist-Height Ratio
+ Young Adult
+Keyword Heading
+ androgens
+ estrogens
+ glycoproteins
+ obesity
+ polycystic ovary syndrome
+ sex
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women in reproductive age. Obesity and low-grade chronic inflammation are frequently associated with PCOS. Recently, proton nuclear magnetic resonance (1H-NMR)-derived glycoprotein profiles have emerged as potential biomarkers that reflect systemic inflammation in type 2 diabetes, obesity, and other pathological processes. The aim of this work is to study plasma glycoprotein profiles as metabolic/inflammatory biomarkers underlying PCOS and its association with inflammation and obesity. We used 1H-NMR spectroscopy to study five glycoprotein variables, namely GlycA, GlycB, and GlycF and the height-to-width (H/W) ratio of GlycA and GlycB, in 17 women with PCOS (9 non-obese and 8 obese), 17 control women (9 non-obese and 8 obese), and 19 healthy men (10 non-obese and 9 obese). H/W ratios of GlycA and GlycB, but not glycoprotein areas, were specifically associated with PCOS independently of obesity. When considered as a whole, obese subjects presented higher GlycA, GlycB, and GlycF areas and higher H/W GlycA and GlycB ratios than their non-obese counterparts. All glycoprotein variables were associated with hsCRP, IL-6, and TNF-alpha, showing different correlations among PCOS, women, and men. Our present exploratory results suggest that 1H-NMR-derived glycoprotein profiles might serve as novel diagnostic markers of low-grade chronic inflammation in women with PCOS.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Glycoproteins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1021%2facs.jproteome.9b00528
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fuertes-Martin&issn=1535-3893&title=Journal+of+Proteome+Research&atitle=Glycoprotein+A+and+B+Height-to-Width+Ratios+as+Obesity-Independent+Novel+Biomarkers+of+Low-Grade+Chronic+Inflammation+in+Women+with+Polycystic+Ovary+Syndrome+%28PCOS%29.&volume=18&issue=11&spage=4038&epage=4045&date=2019&doi=10.1021%2Facs.jproteome.9b00528&pmid=31503497&sid=OVID:medline
+
+<2036>
+Unique Identifier
+ 31503024
+Title
+ Fatty acid-binding proteins: functional understanding and diagnostic implications. [Review]
+Source
+ Current Opinion in Clinical Nutrition & Metabolic Care. 22(6):407-412, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xu H; Diolintzi A; Storch J
+Authors Full Name
+ Xu, Heli; Diolintzi, Anastasia; Storch, Judith.
+Institution
+ Xu, Heli. Department of Nutritional Sciences, Rutgers University, New Brunswick.
+ Xu, Heli. Rutgers Center for Lipid Research, New Jersey, USA.
+ Diolintzi, Anastasia. Department of Kinesiology and Health.
+ Diolintzi, Anastasia. Rutgers Center for Lipid Research, New Jersey, USA.
+ Storch, Judith. Department of Nutritional Sciences, Rutgers University, New Brunswick.
+ Storch, Judith. Rutgers Center for Lipid Research, New Jersey, USA.
+MeSH Subject Headings
+ Animals
+ Biomarkers/an [Analysis]
+ Biomarkers/me [Metabolism]
+ Fatty Acid-Binding Proteins/an [Analysis]
+ Fatty Acid-Binding Proteins/me [Metabolism]
+ Fatty Acid-Binding Proteins/ph [Physiology]
+ *Fatty Acid-Binding Proteins
+ Fatty Acids/me [Metabolism]
+ Humans
+ Mice
+ Neoplasms/di [Diagnosis]
+ Neoplasms/me [Metabolism]
+ Obesity/di [Diagnosis]
+ Obesity/me [Metabolism]
+ Organ Specificity
+Abstract
+ PURPOSE OF REVIEW: Fatty acid-binding proteins (FABPs) are a family of small, abundant proteins with highly tissue-specific expression patterns whose different functions remain incompletely understood. The purpose of this review is to summarize recent findings regarding FABP functions and mechanisms of action, including their potential utilization as serum markers of tissue-specific metabolic diseases.
+
+ RECENT FINDINGS: FABPs are important not only in their tissues of origin but also appear to influence the metabolism and function of tissues distal to their sites of expression. This may be secondary to metabolic changes in their primary tissues, and/or a result of FABP secretion from these tissues leading to effects on distal sites. Their levels in the circulation are increasingly explored as potential biomarkers for tissue-specific disease prognosis and progression.
+
+ SUMMARY: The nine fatty acid-binding members of the FABP family have unique tissue-specific functions and important secondary effects on tissues in which they are not expressed. For many of the FABPs, circulating levels may be indicative of disease processes related to their primary tissues, and may influence physiological function in distal tissues.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Fatty Acid-Binding Proteins). 0 (Fatty Acids).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fMCO.0000000000000600
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xu&issn=1363-1950&title=Current+Opinion+in+Clinical+Nutrition+%26+Metabolic+Care&atitle=Fatty+acid-binding+proteins%3A+functional+understanding+and+diagnostic+implications.&volume=22&issue=6&spage=407&epage=412&date=2019&doi=10.1097%2FMCO.0000000000000600&pmid=31503024&sid=OVID:medline
+
+<2037>
+Unique Identifier
+ 31500176
+Title
+ Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia.
+Source
+ International Journal of Molecular Sciences. 20(18), 2019 Sep 06.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Chang JF; Yeh JC; Ho CT; Liu SH; Hsieh CY; Wang TM; Chang SW; Lee IT; Huang KY; Wang JY; Lin WN
+Author NameID
+ Hsieh, Chih-Yu; ORCID: https://orcid.org/0000-0001-9770-6779
+ Wang, Ting-Ming; ORCID: https://orcid.org/0000-0002-2263-5993
+ Huang, Kuo-Yang; ORCID: https://orcid.org/0000-0002-4038-1579
+ Lin, Wei-Ning; ORCID: https://orcid.org/0000-0003-3205-871X
+Authors Full Name
+ Chang, Jia-Feng; Yeh, Jih-Chen; Ho, Chun-Ta; Liu, Shih-Hao; Hsieh, Chih-Yu; Wang, Ting-Ming; Chang, Shu-Wei; Lee, I-Ta; Huang, Kuo-Yang; Wang, Jen-Yu; Lin, Wei-Ning.
+Institution
+ Chang, Jia-Feng. Division of Nephrology, Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan. cjf6699@gamil.com.
+ Chang, Jia-Feng. Renal Care Joint Foundation, New Taipei City 220, Taiwan. cjf6699@gamil.com.
+ Chang, Jia-Feng. Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan. cjf6699@gamil.com.
+ Chang, Jia-Feng. Graduate Institution of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan. cjf6699@gamil.com.
+ Chang, Jia-Feng. Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan. cjf6699@gamil.com.
+ Yeh, Jih-Chen. Renal Care Joint Foundation, New Taipei City 220, Taiwan. b202093012@tmu.edu.tw.
+ Yeh, Jih-Chen. Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan. b202093012@tmu.edu.tw.
+ Ho, Chun-Ta. Renal Care Joint Foundation, New Taipei City 220, Taiwan. earny2002@gmail.com.
+ Liu, Shih-Hao. Division of Pathology, En-Chu-Kong Hospital, New Taipei City 237, Taiwan. 01393@km.eck.org.tw.
+ Hsieh, Chih-Yu. Division of Nephrology, Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan. fish37435@Hotmail.com.
+ Hsieh, Chih-Yu. Renal Care Joint Foundation, New Taipei City 220, Taiwan. fish37435@Hotmail.com.
+ Wang, Ting-Ming. Department of Orthopaedic Surgery, School of Medicine, National Taiwan University, Taipei 106, Taiwan. dtorth76@yahoo.com.tw.
+ Wang, Ting-Ming. Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei 106, Taiwan. dtorth76@yahoo.com.tw.
+ Chang, Shu-Wei. Department of Civil Engineering, National Taiwan University, Taipei 106, Taiwan. changsw@ntu.edu.tw.
+ Lee, I-Ta. School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan. itlee0128@tmu.edu.tw.
+ Huang, Kuo-Yang. Graduate Institute of Pathology and Parasitology, National Defense Medical Center, Taipei 114, Taiwan. cguhgy6934@gmail.com.
+ Wang, Jen-Yu. Graduate Institution of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan. x123364@gmail.com.
+ Lin, Wei-Ning. Graduate Institution of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan. 081551@mail.fju.edu.tw.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Cyclooxygenase 2/ge [Genetics]
+ Cyclooxygenase 2/me [Metabolism]
+ Disease Models, Animal
+ *Endotoxemia/co [Complications]
+ Epithelial Cells/de [Drug Effects]
+ Epithelial Cells/me [Metabolism]
+ Fibrosis
+ Gene Expression Regulation/de [Drug Effects]
+ Immunohistochemistry
+ Kidney Diseases/dt [Drug Therapy]
+ *Kidney Diseases/et [Etiology]
+ *Kidney Diseases/me [Metabolism]
+ Kidney Diseases/pa [Pathology]
+ Lipid Metabolism
+ Lymphocytes/im [Immunology]
+ Lymphocytes/me [Metabolism]
+ Mice
+ Molecular Targeted Therapy
+ *Obesity/co [Complications]
+ Oxidative Stress
+ *Phospholipases A2, Cytosolic/ge [Genetics]
+ Phospholipases A2, Cytosolic/me [Metabolism]
+ *Reactive Oxygen Species/me [Metabolism]
+ Signal Transduction/de [Drug Effects]
+Keyword Heading
+ ROS
+ cPLA2 and COX-2
+ endotoxemia
+ obese kidney fibrosis
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is associated with metabolic endotoxemia, reactive oxygen species (ROS), chronic inflammation, and obese kidney fibrosis. Although the fat-intestine-kidney axis has been documented, the pathomechanism and therapeutic targets of obese kidney fibrosis remain unelucidated. To mimic obese humans with metabolic endotoxemia, high-fat-diet-fed mice (HF group) were injected with lipopolysaccharide (LPS) to yield the obese kidney fibrosis-metabolic endotoxemia mouse model (HL group). Therapeutic effects of ROS, cytosolic phospholipases A2 (cPLA2) and cyclooxygenase-2 (COX-2) inhibitors were analyzed with a quantitative comparison of immunohistochemistry stains and morphometric approach in the tubulointerstitium of different groups. Compared with basal and HF groups, the HL group exhibited the most prominent obese kidney fibrosis, tubular epithelial lipid vacuoles, and lymphocyte infiltration in the tubulointerstitium. Furthermore, inhibitors of nonspecific ROS, cPLA2 and COX-2 ameliorated the above renal damages. Notably, the ROS-inhibitor-treated group ameliorated not only oxidative injury but also the expression of cPLA2 and COX-2, indicating that ROS functions as the upstream signaling molecule in the inflammatory cascade of obese kidney fibrosis. ROS acts as a key messenger in the signaling transduction of obese kidney fibrosis, activating downstream cPLA2 and COX-2. The given antioxidant treatment ameliorates obese kidney fibrosis resulting from a combined high-fat diet and LPS-ROS could serve as a potential therapeutic target of obese kidney fibrosis with metabolic endotoxemia.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Reactive Oxygen Species). EC 1-14-99-1 (Cyclooxygenase 2). EC 3-1-1-4 (Phospholipases A2, Cytosolic).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20184393
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Chang&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Targeting+ROS+and+cPLA2%2FCOX2+Expressions+Ameliorated+Renal+Damage+in+Obese+Mice+with+Endotoxemia.&volume=20&issue=18&spage=4393&epage=&date=2019&doi=10.3390%2Fijms20184393&pmid=31500176&sid=OVID:medline
+
+<2038>
+Unique Identifier
+ 31498869
+Title
+ Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 104(10):4459-4472, 2019 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kadakia R; Talbot O; Kuang A; Bain JR; Muehlbauer MJ; Stevens RD; Ilkayeva OR; Lowe LP; Metzger BE; Newgard CB; Scholtens DM; Lowe WL
+Corporate Author
+ HAPO Study Cooperative Research Group
+Authors Full Name
+ Kadakia, Rachel; Talbot, Octavious; Kuang, Alan; Bain, James R; Muehlbauer, Michael J; Stevens, Robert D; Ilkayeva, Olga R; Lowe, Lynn P; Metzger, Boyd E; Newgard, Christopher B; Scholtens, Denise M; Lowe, William L.
+Institution
+ Kadakia, Rachel. Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
+ Kadakia, Rachel. Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
+ Talbot, Octavious. Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
+ Kuang, Alan. Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
+ Bain, James R. Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina.
+ Bain, James R. Duke Molecular Physiology Institute, Durham, North Carolina.
+ Bain, James R. Duke University School of Medicine, Durham, North Carolina.
+ Muehlbauer, Michael J. Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina.
+ Muehlbauer, Michael J. Duke Molecular Physiology Institute, Durham, North Carolina.
+ Muehlbauer, Michael J. Duke University School of Medicine, Durham, North Carolina.
+ Stevens, Robert D. Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina.
+ Stevens, Robert D. Duke Molecular Physiology Institute, Durham, North Carolina.
+ Stevens, Robert D. Duke University School of Medicine, Durham, North Carolina.
+ Ilkayeva, Olga R. Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina.
+ Ilkayeva, Olga R. Duke Molecular Physiology Institute, Durham, North Carolina.
+ Ilkayeva, Olga R. Duke University School of Medicine, Durham, North Carolina.
+ Lowe, Lynn P. Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
+ Metzger, Boyd E. Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
+ Newgard, Christopher B. Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina.
+ Newgard, Christopher B. Duke Molecular Physiology Institute, Durham, North Carolina.
+ Newgard, Christopher B. Duke University School of Medicine, Durham, North Carolina.
+ Scholtens, Denise M. Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
+ Lowe, William L. Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Anthropometry
+ Biomarkers/bl [Blood]
+ Birth Weight
+ *C-Peptide/bl [Blood]
+ Cross-Sectional Studies
+ Ethnicity/sn [Statistics & Numerical Data]
+ Female
+ *Fetal Blood/me [Metabolism]
+ Glucose Tolerance Test
+ Humans
+ *Hyperglycemia/bl [Blood]
+ Hyperglycemia/di [Diagnosis]
+ *Hyperinsulinism/bl [Blood]
+ Hyperinsulinism/di [Diagnosis]
+ Infant, Newborn
+ Male
+ Metabolomics/mt [Methods]
+ Native Hawaiian or Other Pacific Islander/eh [Ethnology]
+ *Obesity/bl [Blood]
+ Obesity/eh [Ethnology]
+ Pregnancy
+ Pregnancy Outcome
+ Severity of Illness Index
+Abstract
+ CONTEXT: Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance.
+
+ OBJECTIVE: To determine the association of cord blood metabolites with newborn adiposity and hyperinsulinemia in a multiethnic cohort of newborns.
+
+ DESIGN: Cross-sectional, observational study.
+
+ SETTING: Hyperglycemia and Adverse Pregnancy Outcome study.
+
+ PARTICIPANTS: One thousand six hundred multiethnic mother-newborn pairs.
+
+ MAIN OUTCOME MEASURE: Cord blood C-peptide, birthweight, and newborn sum of skinfolds.
+
+ RESULTS: Meta-analyses across four ancestry groups (Afro-Caribbean, Northern European, Thai, and Mexican American) demonstrated significant associations of cord blood metabolites with cord blood C-peptide, birthweight, and newborn sum of skinfolds. Several metabolites, including branched-chain amino acids (BCAAs), medium- and long-chain acylcarnitines, nonesterified fatty acids, and triglycerides were negatively associated with cord C-peptide but positively associated with birthweight and/or sum of skinfolds. 1,5-Anhydroglucitol, an inverse marker of recent maternal glycemia, was significantly inversely associated with birthweight and sum of skinfolds. Network analyses revealed groups of interrelated amino acid, acylcarnitine, and fatty acid metabolites associated with all three newborn outcomes.
+
+ CONCLUSIONS: Cord blood metabolites are associated with newborn size and cord blood C-peptide levels after adjustment for maternal body mass index and glucose during pregnancy. Negative associations of metabolites with C-peptide at birth were observed. 1,5-Anhydroglucitol appears to be a marker of adiposity in newborns. BCAAs were individually associated with birthweight and demonstrated possible associations with newborn adiposity in network analyses. Copyright © 2019 Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C-Peptide).
+Publication Type
+ Journal Article. Observational Study. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1210%2fjc.2019-00238
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kadakia&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Cord+Blood+Metabolomics%3A+Association+With+Newborn+Anthropometrics+and+C-Peptide+Across+Ancestries.&volume=104&issue=10&spage=4459&epage=4472&date=2019&doi=10.1210%2Fjc.2019-00238&pmid=31498869&sid=OVID:medline
+
+<2039>
+Unique Identifier
+ 31493478
+Title
+ Strength training reduces lipid accumulation in liver of obese Wistar rats.
+Source
+ Life Sciences. 235:116834, 2019 Oct 15.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dos Santos GF; Veras ASC; de Freitas MC; McCabe J; Seraphim PM; Teixeira GR
+Authors Full Name
+ Dos Santos, Giulia Fonseca; Veras, Allice Santos Cruz; de Freitas, Marcelo Conrado; McCabe, James; Seraphim, Patricia Monteiro; Teixeira, Giovana Rampazzo.
+Institution
+ Dos Santos, Giulia Fonseca. Graduated Physical Education, Sao Paulo State University-UNESP, campus of Presidente Prudente, Sao Paulo, SP, Brazil.
+ Veras, Allice Santos Cruz. Postgraduate Program in Movement Sciences, Sao Paulo State University-UNESP, campus of Presidente Prudente, Sao Paulo, SP, Brazil.
+ de Freitas, Marcelo Conrado. Postgraduate Program in Movement Sciences, Sao Paulo State University-UNESP, campus of Presidente Prudente, Sao Paulo, SP, Brazil.
+ McCabe, James. Department of Plant Agriculture, University of Guelph, ON, Canada.
+ Seraphim, Patricia Monteiro. Department of Physiotherapy, School of Technology and Sciences, UNESP, campus of Presidente Prudente, Sao Paulo, SP, Brazil.
+ Teixeira, Giovana Rampazzo. Postgraduate Program in Movement Sciences, Sao Paulo State University-UNESP, campus of Presidente Prudente, Sao Paulo, SP, Brazil. Electronic address: giovana.rampazzo@unesp.br.
+MeSH Subject Headings
+ Animals
+ Biomarkers/me [Metabolism]
+ Diet, High-Fat/ae [Adverse Effects]
+ Glycogen/me [Metabolism]
+ *Lipid Metabolism
+ Lipogenesis
+ *Liver/me [Metabolism]
+ Male
+ *Obesity/me [Metabolism]
+ Oxidation-Reduction
+ *Physical Conditioning, Animal/ph [Physiology]
+ Proteins/me [Metabolism]
+ Rats
+Keyword Heading
+ Anaerobic training
+ CD36
+ Liver
+ Obesity
+ SREBP-1
+ Strength training
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity has a positive relation to non-alcoholic fatty liver disease (NAFLD) and studies have demonstrated that strength training can regulate lipid accumulation in the hepatocytes of obese rats.
+
+ AIMS: Our aim is to evaluate the effects of high fat diet and strength training on markers of oxidation and lipogenesis in the liver of Wistar rats.
+
+ MAIN METHODS: Forty Wistar rats were divided into four groups (n=10): control (CTL), strength training (TR), high fat diet consumption (HF) and high fat diet consumption with strength training (HFT). Animals were subjected to physical strength training and high fat diet consumption for 12weeks, 3 session per week. Then, the animals were euthanized, and liver markers were evaluated via immunolabeling.
+
+ KEY FINDINGS: Our results indicated that strength training reduced the expression of adiposity as well as the accumulation of glycogen and lipids in the liver. This reduction of fatty acid (FA) stored in hepatocytes is related to reduction of proteins linked to beta-oxidation such as Fas/CD95, LIMP-II and CD36, as well as other proteins linked to lipogeneses such as SREBP-1.
+
+ SIGNIFICANCE: Finally, we observed that high fat diet can alter lipogenesis and reduce beta-oxidation promoted hepatic fat accumulation. In conclusion, there was a reduction of obesity-related hepatic lipogenesis after 12weeks of strength training. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Proteins). 9005-79-2 (Glycogen).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.lfs.2019.116834
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dos+Santos&issn=0024-3205&title=Life+Sciences&atitle=Strength+training+reduces+lipid+accumulation+in+liver+of+obese+Wistar+rats.&volume=235&issue=&spage=116834&epage=&date=2019&doi=10.1016%2Fj.lfs.2019.116834&pmid=31493478&sid=OVID:medline
+
+<2040>
+Unique Identifier
+ 31491949
+Title
+ Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis.
+Source
+ International Journal of Molecular Sciences. 20(18), 2019 Sep 05.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Salic K; Gart E; Seidel F; Verschuren L; Caspers M; van Duyvenvoorde W; Wong KE; Keijer J; Bobeldijk-Pastorova I; Wielinga PY; Kleemann R
+Author NameID
+ Verschuren, Lars; ORCID: https://orcid.org/0000-0002-7847-9037
+ Caspers, Martien; ORCID: https://orcid.org/0000-0002-0248-4008
+ Keijer, Jaap; ORCID: https://orcid.org/0000-0002-9720-7491
+ Kleemann, Robert; ORCID: https://orcid.org/0000-0002-1350-0149
+Authors Full Name
+ Salic, Kanita; Gart, Eveline; Seidel, Florine; Verschuren, Lars; Caspers, Martien; van Duyvenvoorde, Wim; Wong, Kari E; Keijer, Jaap; Bobeldijk-Pastorova, Ivana; Wielinga, Peter Y; Kleemann, Robert.
+Institution
+ Salic, Kanita. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands. Kanita.salic@tno.nl.
+ Gart, Eveline. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands. Eveline.gart@tno.nl.
+ Gart, Eveline. Human and Animal Physiology, Wageningen University, 6708 WD Wageningen, The Netherlands. Eveline.gart@tno.nl.
+ Seidel, Florine. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands. Florine.seidel@tno.nl.
+ Verschuren, Lars. Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), 3704 HE Zeist, The Netherlands. Lars.Verschuren@tno.nl.
+ Caspers, Martien. Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), 3704 HE Zeist, The Netherlands. Martien.caspers@tno.nl.
+ van Duyvenvoorde, Wim. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands. Wim.vanduyvenvoorde@tno.nl.
+ Wong, Kari E. Metabolon Inc., Morrisville, NC 27560, USA. KWong@metabolon.com.
+ Keijer, Jaap. Human and Animal Physiology, Wageningen University, 6708 WD Wageningen, The Netherlands. Jaap.keijer@wur.nl.
+ Bobeldijk-Pastorova, Ivana. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands. Ivana.bobeldijk@tno.nl.
+ Wielinga, Peter Y. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands. WielingaPeter@prahs.com.
+ Kleemann, Robert. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands. Robert.kleemann@tno.nl.
+ Kleemann, Robert. Department of Vascular Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. Robert.kleemann@tno.nl.
+MeSH Subject Headings
+ Animals
+ Biomarkers
+ *Carnitine/pd [Pharmacology]
+ Disease Models, Animal
+ Energy Metabolism/de [Drug Effects]
+ Fatty Liver/dt [Drug Therapy]
+ Fatty Liver/ge [Genetics]
+ *Fatty Liver/me [Metabolism]
+ Gene Expression Regulation
+ Lipid Metabolism/de [Drug Effects]
+ Male
+ Mice
+ Mice, Knockout
+ *Niacinamide/aa [Analogs & Derivatives]
+ Niacinamide/pd [Pharmacology]
+ Obesity/dt [Drug Therapy]
+ Obesity/ge [Genetics]
+ *Obesity/me [Metabolism]
+ Oxidative Stress
+ Pyridinium Compounds
+ Signal Transduction
+Keyword Heading
+ acylcarnitines
+ lipid peroxidation
+ metabolomics
+ mitochondria
+ non-alcoholic fatty liver disease
+ obesity
+ transcriptomics
+ beta-oxidation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity characterized by adiposity and ectopic fat accumulation is associated with the development of non-alcoholic fatty liver disease (NAFLD). Treatments that stimulate lipid utilization may prevent the development of obesity and comorbidities. This study evaluated the potential anti-obesogenic hepatoprotective effects of combined treatment with L-carnitine and nicotinamide riboside, i.e., components that can enhance fatty acid transfer across the inner mitochondrial membrane and increase nicotinamide adenine nucleotide (NAD+) levels, which are necessary for beta-oxidation and the TCA cycle, respectively. Ldlr -/-.Leiden mice were treated with high-fat diet (HFD) supplemented with L-carnitine (LC; 0.4% w/w), nicotinamide riboside (NR; 0.3% w/w) or both (COMBI) for 21 weeks. L-carnitine plasma levels were reduced by HFD and normalized by LC. NR supplementation raised its plasma metabolite levels demonstrating effective delivery. Although food intake and ambulatory activity were comparable in all groups, COMBI treatment significantly attenuated HFD-induced body weight gain, fat mass gain (-17%) and hepatic steatosis (-22%). Also, NR and COMBI reduced hepatic 4-hydroxynonenal adducts. Upstream-regulator gene analysis demonstrated that COMBI reversed detrimental effects of HFD on liver metabolism pathways and associated regulators, e.g., ACOX, SCAP, SREBF, PPARGC1B, and INSR. Combination treatment with LC and NR exerts protective effects on metabolic pathways and constitutes a new approach to attenuate HFD-induced obesity and NAFLD.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Pyridinium Compounds). 0I8H2M0L7N (nicotinamide-beta-riboside). 25X51I8RD4 (Niacinamide). S7UI8SM58A (Carnitine).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20184359
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Salic&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Combined+Treatment+with+L-Carnitine+and+Nicotinamide+Riboside+Improves+Hepatic+Metabolism+and+Attenuates+Obesity+and+Liver+Steatosis.&volume=20&issue=18&spage=4359&epage=&date=2019&doi=10.3390%2Fijms20184359&pmid=31491949&sid=OVID:medline
+
+<2041>
+Unique Identifier
+ 31483797
+Title
+ Posturographic characteristics of the standing posture and the effects of the treatment of obesity on obese young women.
+Source
+ PLoS ONE [Electronic Resource]. 14(9):e0220962, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Cieslinska-Swider JM; Blaszczyk JW
+Author NameID
+ Cieslinska-Swider, Joanna Magdalena; ORCID: https://orcid.org/0000-0003-1477-8641
+Authors Full Name
+ Cieslinska-Swider, Joanna Magdalena; Blaszczyk, Janusz Wieslaw.
+Institution
+ Cieslinska-Swider, Joanna Magdalena. The Jerzy Kukuczka Academy of Physical Education, Department of Physiotherapy of the Nervous System and the Musculoskeletal System, Katowice, Poland.
+ Blaszczyk, Janusz Wieslaw. The Jerzy Kukuczka Academy of Physical Education, Department of Human Motor Behavior, Katowice, Poland.
+MeSH Subject Headings
+ Adult
+ Biomarkers
+ Body Weight
+ Female
+ Humans
+ *Obesity/pa [Pathology]
+ *Obesity/th [Therapy]
+ *Postural Balance
+ *Posture
+ Sex Factors
+ *Standing Position
+Abstract
+ To determine the impact of body weight on quiet standing postural sway characteristics in young women, this research compared spontaneous oscillations of the center of foot pressure (COP) between 32 obese (BMI: 36.4 +/- 5.2 kg/m2), and 26 normal-weight (BMI: 21.4 +/- 1.5 kg/m2) women and assessed the influence of obesity treatment and body weight reduction on postural sway. Trajectories of the COP were assessed while the subjects were standing quietly with eyes open (EO) and closed (EC). Both in the sagittal (AP) and frontal (ML) planes the sway range, average velocity, and maximal velocity of COP were calculated. Moreover, the total average and maximal velocities were computed. In the obese group, the tests were performed twice-before and after the obesity treatment. A greater (18% in EC) AP sway range and a substantial reduction of ML sway (25% in EO, 22% in EC) were observed in the obese women. The total COP velocities (average and maximal) were decreased in obese women (20% and 20% in EO) as well as the velocities in the frontal plane (EO: 33%, 41%; EC: 34%, 40%). Body weight reduction resulted in significant changes in postural sway. The following parameters increased: ML sway range (28% in EO), average (20% in EO, 16% in EC) and maximal ML (20% in EO) velocities. The results indicate that young obese women in the habitual standing position are characterized by the destabilizing influence of mass in the sagittal plane only in the absence of a visual control. This effect is dominated by the stabilizing mass effect in the frontal plane, which affects overall postural stability when standing. The reduction of body mass enables a decrease in ML static stability, likely due to natural changes in the base of support while standing.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1371%2fjournal.pone.0220962
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Cieslinska-Swider&issn=1932-6203&title=PLoS+ONE+%5BElectronic+Resource%5D&atitle=Posturographic+characteristics+of+the+standing+posture+and+the+effects+of+the+treatment+of+obesity+on+obese+young+women.&volume=14&issue=9&spage=e0220962&epage=&date=2019&doi=10.1371%2Fjournal.pone.0220962&pmid=31483797&sid=OVID:medline
+
+<2042>
+Unique Identifier
+ 31480394
+Title
+ Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats.
+Source
+ International Journal of Molecular Sciences. 20(17), 2019 08 30.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bukosza EN; Kaucsar T; Godo M; Lajtar E; Tod P; Koncsos G; Varga ZV; Baranyai T; Nguyen MT; Schachner H; Soti C; Ferdinandy P; Giricz Z; Szenasi G; Hamar P
+Author NameID
+ Soti, Csaba; ORCID: https://orcid.org/0000-0002-4057-7678
+ Giricz, Zoltan; ORCID: https://orcid.org/0000-0003-2036-8665
+ Hamar, Peter; ORCID: https://orcid.org/0000-0002-1095-3564
+Authors Full Name
+ Bukosza, Eva Nora; Kaucsar, Tamas; Godo, Maria; Lajtar, Eniko; Tod, Pal; Koncsos, Gabor; Varga, Zoltan V; Baranyai, Tamas; Nguyen, Minh Tu; Schachner, Helga; Soti, Csaba; Ferdinandy, Peter; Giricz, Zoltan; Szenasi, Gabor; Hamar, Peter.
+Institution
+ Bukosza, Eva Nora. Institute of Pathophysiology, Semmelweis University, H-1089 Budapest, Hungary.
+ Bukosza, Eva Nora. Department of Pathology, Medical University of Vienna, 1090 Wien, Austria.
+ Kaucsar, Tamas. Institute of Pathophysiology, Semmelweis University, H-1089 Budapest, Hungary.
+ Godo, Maria. Institute of Pathophysiology, Semmelweis University, H-1089 Budapest, Hungary.
+ Lajtar, Eniko. Institute of Pathophysiology, Semmelweis University, H-1089 Budapest, Hungary.
+ Tod, Pal. Institute of Pathophysiology, Semmelweis University, H-1089 Budapest, Hungary.
+ Koncsos, Gabor. Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.
+ Varga, Zoltan V. Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.
+ Baranyai, Tamas. Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.
+ Nguyen, Minh Tu. Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, H-1089 Budapest, Hungary.
+ Schachner, Helga. Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, H-1089 Budapest, Hungary.
+ Soti, Csaba. Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, H-1089 Budapest, Hungary.
+ Ferdinandy, Peter. Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.
+ Ferdinandy, Peter. Pharmahungary Group, H-1089 Budapest, Hungary.
+ Giricz, Zoltan. Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary. giricz.zoltan@med.semmelweis-univ.hu.
+ Szenasi, Gabor. Institute of Pathophysiology, Semmelweis University, H-1089 Budapest, Hungary. szenasi.gabor@med.semmelweis-univ.hu.
+ Hamar, Peter. Institute of Pathophysiology, Semmelweis University, H-1089 Budapest, Hungary. hamar.peter@med.semmelweis-univ.hu.
+ Hamar, Peter. Institute of Clinical Experimental Research, Semmelweis University, H-1089 Budapest, Hungary. hamar.peter@med.semmelweis-univ.hu.
+ Hamar, Peter. Institute of Translational Medicine, Pecs University, 7624 Pecs, Hungary. hamar.peter@med.semmelweis-univ.hu.
+MeSH Subject Headings
+ Adipose Tissue/me [Metabolism]
+ Animals
+ Biomarkers/me [Metabolism]
+ Body Weight
+ *Collagen/me [Metabolism]
+ Diet, High-Fat
+ Fibrosis
+ Gene Expression Regulation
+ Inflammation/ge [Genetics]
+ Inflammation/pa [Pathology]
+ *Kidney Glomerulus/in [Injuries]
+ *Kidney Glomerulus/me [Metabolism]
+ Kidney Glomerulus/pa [Pathology]
+ Lipids/bl [Blood]
+ *Lipocalin-2/me [Metabolism]
+ Liver/en [Enzymology]
+ Liver/pa [Pathology]
+ Liver/pp [Physiopathology]
+ Male
+ MicroRNAs/ge [Genetics]
+ MicroRNAs/me [Metabolism]
+ Obesity/bl [Blood]
+ *Obesity/me [Metabolism]
+ Oxidative Stress/ge [Genetics]
+ Phosphorylation
+ Phosphoserine/me [Metabolism]
+ Prediabetic State/bl [Blood]
+ *Prediabetic State/me [Metabolism]
+ Proto-Oncogene Proteins c-akt/me [Metabolism]
+ RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+ Rats, Long-Evans
+ Streptozocin
+Keyword Heading
+ collagen type IV
+ inflammation
+ lipocalin-2
+ obesity
+ renal injury
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and mild diastolic dysfunction as published before by Koncsos et al. in 2016. Here we aimed to explore the renal consequences in the same groups of rats. Male Long-Evans rats were fed normal chow (CON; n = 9) or HFD containing 40% lard and were administered STZ at 20 mg/kg (i.p.) at week four (prediabetic rats, PRED, n = 9). At week 21 blood and urine samples were taken and kidney and liver samples were collected for histology, immunohistochemistry and for analysis of gene expression. HFD and STZ increased body weight and visceral adiposity and plasma leptin concentration. Despite hyperleptinemia, plasma C-reactive protein concentration decreased in PRED rats. Immunohistochemistry revealed elevated collagen IV protein expression in the glomeruli, and Lcn2 mRNA expression increased, while Il-1beta mRNA expression decreased in both the renal cortex and medulla in PRED vs. CON rats. Kidney histology, urinary protein excretion, plasma creatinine, glomerular Feret diameter, desmin protein expression, and cortical and medullary mRNA expression of TGF-beta1, Nrf2, and PPARgamma were similar in CON and PRED rats. Reduced AMPKalpha phosphorylation of the autophagy regulator Akt was the first sign of liver damage, while plasma lipid and liver enzyme concentrations were similar. In conclusion, glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury, while most biomarkers of inflammation, oxidative stress and fibrosis were negative in the kidneys of obese, prediabetic rats with mild heart and liver injury.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Lipids). 0 (Lipocalin-2). 0 (MicroRNAs). 0 (RNA, Messenger). 17885-08-4 (Phosphoserine). 5W494URQ81 (Streptozocin). 9007-34-5 (Collagen). EC 2-7-11-1 (Proto-Oncogene Proteins c-akt).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijms20174266
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bukosza&issn=1422-0067&title=International+Journal+of+Molecular+Sciences&atitle=Glomerular+Collagen+Deposition+and+Lipocalin-2+Expression+Are+Early+Signs+of+Renal+Injury+in+Prediabetic+Obese+Rats.&volume=20&issue=17&spage=4266&epage=&date=2019&doi=10.3390%2Fijms20174266&pmid=31480394&sid=OVID:medline
+
+<2043>
+Unique Identifier
+ 31479091
+Title
+ Epicardial, paracardial, and perivascular fat quantity, gene expressions, and serum cytokines in patients with coronary artery disease and diabetes.
+Source
+ Polish Archives Of Internal Medicine. 129(11):738-746, 2019 11 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Haberka M; Machnik G; Kowalowka A; Biedron M; Skudrzyk E; Regulska-Ilow B; Gajos G; Manka R; Deja M; Okopien B; Gasior Z
+Authors Full Name
+ Haberka, Maciej; Machnik, Grzegorz; Kowalowka, Adam; Biedron, Malgorzata; Skudrzyk, Estera; Regulska-Ilow, Bozena; Gajos, Grzegorz; Manka, Robert; Deja, Marek; Okopien, Boguslaw; Gasior, Zbigniew.
+Institution
+ Haberka, Maciej. Department of Cardiology, School of Health Sciences, Medical University of Silesia, Katowice, Poland. mhaberka@op.pl
+ Machnik, Grzegorz. Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
+ Kowalowka, Adam. Department of Cardiac Surgery, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
+ Biedron, Malgorzata. Department of Cardiology, School of Health Sciences, Medical University of Silesia, Katowice, Poland
+ Skudrzyk, Estera. Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
+ Regulska-Ilow, Bozena. Division of Dietetics, Wroclaw Medical University, Wroclaw, Poland
+ Gajos, Grzegorz. Department of Coronary Disease and Heart Failure, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
+ Manka, Robert. Department of Cardiology, University Hospital Zurich, Zurich, Switzerland
+ Deja, Marek. Department of Cardiac Surgery, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
+ Okopien, Boguslaw. Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
+ Gasior, Zbigniew. Department of Cardiology, School of Health Sciences, Medical University of Silesia, Katowice, Poland
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ *Adipose Tissue/pp [Physiopathology]
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Comorbidity
+ Coronary Artery Disease/bl [Blood]
+ Coronary Artery Disease/ep [Epidemiology]
+ *Coronary Artery Disease/pp [Physiopathology]
+ *Cytokines/bl [Blood]
+ *Diabetes Complications/pp [Physiopathology]
+ Diabetes Mellitus/bl [Blood]
+ Diabetes Mellitus/ep [Epidemiology]
+ *Diabetes Mellitus/pp [Physiopathology]
+ Female
+ Gene Expression Regulation
+ Humans
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/co [Complications]
+ *Obesity/pp [Physiopathology]
+ *Pericardium/pp [Physiopathology]
+Abstract
+ INTRODUCTION: Obesity and diabetes mellitus (DM) are common disorders that increase cardiovascular risk and lead to coronary artery disease (CAD).
+
+ OBJECTIVES: The aim of our study was to assess the link between epicardial fat (EF) volume and paracardial fat (PF) volume, relative expressions of several genes in epicardial, paracardial, and perivascular fat and corresponding serum cytokines in patients with CAD in relation to DM.
+
+ PATIENTS AND METHODS: A total of 66 consecutive patients (33 with DM) with multivessel CAD were included. We obtained cardiac magnetic resonance, serum cytokines levels, and their relative mRNA expressions in EF, PF, and perivascular fat samples of the following: adrenomedullin (ADM), fibroblast growth factor 21 (FGF21), transforming growth factor beta (TGFbeta), phospholipid transfer protein (PLTP), receptor for advanced glycation endproducts (RAGE), thrombospondin 1 (THSB1), and uncoupling protein 1 (UCP1).
+
+ RESULTS: There were no differences in the anthropometric parameters or fat depots, except for higher epicardial fat volume in patients with DM (mean [SD], 105.6 [38.5] ml vs 84 [29.2] ml; P = 0.02). Patients with DM exhibited a significantly increased RAGE expression in EF (median [Q1-Q3], 0.17 [0.06-1.48] AU vs 0.08 [0.02-0.24] AU, P = 0.03). Diabetes was also associated with increased expression of ADM in EF and PF and decreased expression of FGF21 compared with patients without DM.
+
+ CONCLUSIONS: Patients with multivessel CAD and DM revealed increased volume and more dysfunctional profile of gene expressions in EF and significantly decreased expression of cardioprotective FGF21.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cytokines).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.20452%2fpamw.14961
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Haberka&issn=0032-3772&title=Polish+Archives+Of+Internal+Medicine&atitle=Epicardial%2C+paracardial%2C+and+perivascular+fat+quantity%2C+gene+expressions%2C+and+serum+cytokines+in+patients+with+coronary+artery+disease+and+diabetes.&volume=129&issue=11&spage=738&epage=746&date=2019&doi=10.20452%2Fpamw.14961&pmid=31479091&sid=OVID:medline
+
+<2044>
+Unique Identifier
+ 31479035
+Title
+ Comparative effects of high-intensity interval training with combined training on physical function markers in obese postmenopausal women: a randomized controlled trial.
+Source
+ Menopause. 26(11):1242-1249, 2019 11.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nunes PRP; Martins FM; Souza AP; Carneiro MAS; Nomelini RS; Michelin MA; Murta EFC; de Oliveira EP; Orsatti FL
+Authors Full Name
+ Nunes, Paulo R P; Martins, Fernanda M; Souza, Aleteia P; Carneiro, Marcelo A S; Nomelini, Rosekeila S; Michelin, Marcia A; Murta, Eddie F C; de Oliveira, Erick P; Orsatti, Fabio L.
+Institution
+ Nunes, Paulo R P. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Martins, Fernanda M. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Souza, Aleteia P. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Carneiro, Marcelo A S. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Nomelini, Rosekeila S. Oncology Research Institute (IPON), Gynecology and Obstetrics Program, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Michelin, Marcia A. Oncology Research Institute (IPON), Gynecology and Obstetrics Program, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Murta, Eddie F C. Oncology Research Institute (IPON), Gynecology and Obstetrics Program, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ de Oliveira, Erick P. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ de Oliveira, Erick P. School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil.
+ Orsatti, Fabio L. Exercise Biology Research Group (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+ Orsatti, Fabio L. Department of Sport Sciences, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ Body Composition
+ Body Weight
+ Comparative Effectiveness Research
+ Exercise/ph [Physiology]
+ *Exercise Therapy/mt [Methods]
+ Female
+ Heart Rate
+ *High-Intensity Interval Training/mt [Methods]
+ Humans
+ Middle Aged
+ Muscle Strength
+ *Obesity/pp [Physiopathology]
+ *Obesity/th [Therapy]
+ Physical Functional Performance
+ *Postmenopause
+ Resistance Training/mt [Methods]
+ Treatment Outcome
+ Walking/ph [Physiology]
+Abstract
+ OBJECTIVES: This study compared the effects of high-intensity interval training (HIIT) with effects of combined training (CT) on physical function, body composition, and muscle strength in obese postmenopausal women (PW) (trial registration: NCT03200639).
+
+ METHODS: PW were randomized to CT (n = 12) and HIIT (n = 12). The CT group performed 30 minutes of moderate walking at 70% of maximum heart rate (MHR) and five resistance exercises at 70% of one repetition maximum (1RM) for 12 weeks. The HIIT group performed 10 sets of vigorous exercises (30 seconds (s) of stair climbing and 30 s of body weight squats) at >80% MHR interspersed by a light walk (recovery period at 60% MHR).
+
+ RESULTS: Both groups reduced body fat percentage (0.5%), chair stand (3 s) and increased leg lean mass (0.3 kg). Only the CT, however, increased muscle strength (29%) and fast walking speed (5%) compared with HIIT. The fast walking speed changes were partially explained by the muscle strength changes (36%, r = 0.60, P = 0.027) in the CT group.
+
+ CONCLUSIONS: These results suggest that HIIT is an alternative time-efficient protocol for improving chair stand and body composition when compared with CT, whereas only CT is an efficient protocol for improving muscular strength and fast walking speed in obese PW. Thus, CT must be prioritized when the increase of muscular strength and fast walking speed are the goals of training. : Video Summary: Supplemental Digital Content 1, http://links.lww.com/MENO/A443.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1097%2fGME.0000000000001399
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nunes&issn=1072-3714&title=Menopause&atitle=Comparative+effects+of+high-intensity+interval+training+with+combined+training+on+physical+function+markers+in+obese+postmenopausal+women%3A+a+randomized+controlled+trial.&volume=26&issue=11&spage=1242&epage=1249&date=2019&doi=10.1097%2FGME.0000000000001399&pmid=31479035&sid=OVID:medline
+
+<2045>
+Unique Identifier
+ 31472689
+Title
+ Metabolic-related markers and inflammatory factors as predictors of dyslipidemia among urban Han Chinese adults.
+Source
+ Lipids in Health & Disease. 18(1):167, 2019 Aug 31.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lian Y; Xie L; Liu Y; Tang F
+Author NameID
+ Tang, Fang; ORCID: http://orcid.org/0000-0002-4378-594X
+Authors Full Name
+ Lian, Ying; Xie, Lingling; Liu, Yafei; Tang, Fang.
+Institution
+ Lian, Ying. Center for Data Science in Health and Medicine, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jingshi Road 16766, Jinan, 250014, China.
+ Lian, Ying. Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, Jinan, China.
+ Xie, Lingling. Department of Endocrinology, Zhangqiu District Hospital of Traditional Chinese Medicine, Jinan, China.
+ Liu, Yafei. Center for Data Science in Health and Medicine, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jingshi Road 16766, Jinan, 250014, China.
+ Liu, Yafei. Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, Jinan, China.
+ Tang, Fang. Center for Data Science in Health and Medicine, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jingshi Road 16766, Jinan, 250014, China. tangfangsdu@126.com.
+ Tang, Fang. Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, Jinan, China. tangfangsdu@126.com.
+MeSH Subject Headings
+ Adult
+ Asian People
+ Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Blood Pressure/ph [Physiology]
+ Blood Urea Nitrogen
+ Cholesterol, HDL/bl [Blood]
+ Cholesterol, LDL/bl [Blood]
+ Dyslipidemias/bl [Blood]
+ *Dyslipidemias/di [Diagnosis]
+ Dyslipidemias/eh [Ethnology]
+ Female
+ Humans
+ Inflammation
+ Least-Squares Analysis
+ Life Style
+ Lipid Metabolism
+ Male
+ Metabolic Syndrome/bl [Blood]
+ *Metabolic Syndrome/di [Diagnosis]
+ Metabolic Syndrome/eh [Ethnology]
+ Middle Aged
+ Neutrophils/me [Metabolism]
+ Neutrophils/pa [Pathology]
+ Obesity/bl [Blood]
+ *Obesity/di [Diagnosis]
+ Obesity/eh [Ethnology]
+ Prospective Studies
+ Risk
+ Triglycerides/bl [Blood]
+ Urban Population
+ gamma-Glutamyltransferase/bl [Blood]
+Keyword Heading
+ Cohort study
+ Dyslipidemia
+ Inflammation
+ Mediation
+ Metabolic-related markers
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Metabolic-related markers and inflammatory factors have been proved to be associated with increased risk of dyslipidemia. Elucidating the mechanisms underlying these associations might provide an important perspective for the prevention of dyslipidemia. In the present study, we aimed to explore the effect of metabolic-related markers on dyslipidemia, and to assess what extent inflammation mediating these associations.
+
+ METHODS: A total of 25,130 participants without dyslipidemia at baseline were included in the present study during 2010-2015. A partial least squares path model was used to explore possible pathways from metabolic-related markers to dyslipidemia, and the mediation role of inflammation.
+
+ RESULTS: Lipid metabolism factor, blood pressure factor, obesity condition factor, glucose metabolism factor, renal function factor and lifestyle factor had diverse impact on development of dyslipidemia, directly and (or) indirectly. Partial least squares path analysis revealed that the determination coefficient of the model (R2) was 0.52. Lipid metabolism factor, obesity condition factor, and glucose metabolism factor had both direct and indirect effect on dyslipidemia through inflammatory factor. Lipid metabolism factor was the most important risk factor (beta = 0.68) in the prediction of dyslipidemia, followed by obesity condition factor (beta = 0.06) and glucose metabolism factor (beta = 0.03).
+
+ CONCLUSIONS: Metabolic-related markers are strong risk factors for dyslipidemia. Inflammatory factors have significant mediating effect on these relationships. These findings suggested that comprehensive intervention strategies on metabolic biomarkers and inflammatory factors should be taken into consideration in prevention and treatment of dyslipidemia.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Cholesterol, HDL). 0 (Cholesterol, LDL). 0 (Triglycerides). EC 2-3-2-2 (gamma-Glutamyltransferase).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12944-019-1109-1
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lian&issn=1476-511X&title=Lipids+in+Health+%26+Disease&atitle=Metabolic-related+markers+and+inflammatory+factors+as+predictors+of+dyslipidemia+among+urban+Han+Chinese+adults.&volume=18&issue=1&spage=167&epage=&date=2019&doi=10.1186%2Fs12944-019-1109-1&pmid=31472689&sid=OVID:medline
+
+<2046>
+Unique Identifier
+ 31472061
+Title
+ Triglyceride/glucose index is a reliable alternative marker for insulin resistance in South American overweight and obese children and adolescents.
+Source
+ Journal of Pediatric Endocrinology & Metabolism. 32(10):1163-1170, 2019 Oct 25.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Locateli JC; Lopes WA; Simoes CF; de Oliveira GH; Oltramari K; Bim RH; de Souza Mendes VH; Remor JM; Lopera CA; Nardo Junior N
+Author NameID
+ de Oliveira, Gustavo Henrique; ORCID: https://orcid.org/0000-0002-7708-1828
+Authors Full Name
+ Locateli, Joao Carlos; Lopes, Wendell Arthur; Simoes, Caroline Ferraz; de Oliveira, Gustavo Henrique; Oltramari, Karine; Bim, Ricardo Henrique; de Souza Mendes, Victor Hugo; Remor, Jane Maria; Lopera, Carlos Andres; Nardo Junior, Nelson.
+Institution
+ Locateli, Joao Carlos. Department of Physical Education, State University of Maringa, Maringa, Brazil.
+ Lopes, Wendell Arthur. Department of Physical Education, State University of Maringa, Av. Colombo, 5.790, Campus Universitario, Maringa,Parana 87020-90, Brazil, Phone: +55(44)998794895, E-mail:gustavohdeoli@gmail.com.
+ Simoes, Caroline Ferraz. Department of Physical Education, State University of Maringa, Maringa, Brazil.
+ de Oliveira, Gustavo Henrique. Department of Physical Education, State University of Maringa, Av. Colombo, 5.790, Campus Universitario, Maringa,Parana 87020-90, Brazil, Phone: +55(44)998794895, E-mail:gustavohdeoli@gmail.com.
+ Oltramari, Karine. Multiprofessional Nucleus of Obesity Studies, Maringa, Brazil.
+ Bim, Ricardo Henrique. Multiprofessional Nucleus of Obesity Studies, Maringa, Brazil.
+ de Souza Mendes, Victor Hugo. Department of Physical Education, State University of Maringa, Maringa, Brazil.
+ Remor, Jane Maria. Department of Physical Education, State University of Maringa, Maringa, Brazil.
+ Lopera, Carlos Andres. University of Tolima, Tolima, Colombia.
+ Nardo Junior, Nelson. Department of Physical Education, State University of Maringa, Maringa, Brazil.
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adolescent
+ *Biomarkers/bl [Blood]
+ *Blood Glucose/an [Analysis]
+ Child
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Glucose Intolerance/bl [Blood]
+ *Glucose Intolerance/di [Diagnosis]
+ Glucose Intolerance/ep [Epidemiology]
+ Humans
+ Incidence
+ *Insulin Resistance
+ Male
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ South America/ep [Epidemiology]
+ *Triglycerides/bl [Blood]
+Keyword Heading
+ South America
+ adolescents
+ children
+ insulin resistance
+ overweight
+ triglyceride/glucose index
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background The aim of the present study was to investigate the correlation between the triglyceride/glucose index (TyG index) and homeostasis model assessment of insulin resistance (HOMA-IR). Additionally, we compared the ability of the TyG index and triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) index and the combination of these two indices (TyG index plus TG/HDL-c) to predict insulin resistance (IR) in South American overweight and obese children and adolescents. Methods A cross-sectional study was carried out in 345 overweight adolescents aged 10-18 years, from both the sexes. The TyG index was calculated as Ln (fasting triglycerides [mg/dL] x fasting glucose [mg/dL])/2, while the TG/HDL-c index was calculated by the division of TG (mg/dL) by HDL-c (mg/dL). HOMA-IR was calculated with the formula: fasting insulin (FI) (U/mL) x fasting glucose (mmol/L)/22.5. The cut-off point used to determine the presence of IR was HOMA-IR >= 3.16. Results The TyG index showed a positive correlation with HOMA-IR. The area under the receiver operating characteristic (ROC) curve of the TyG index was 0.74, indicating good sensitivity (75.7%) and specificity (67.4%). Furthermore, the TyG index cut-off point of >4.44 was established for IR prediction in this population. Conclusions The TyG index is a simple and cost-effective surrogate marker of IR in South American overweight children and adolescents. Moreover, due to its good accessibility, it can be used in large epidemiological studies.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Triglycerides).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fjpem-2019-0037
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Locateli&issn=0334-018X&title=Journal+of+Pediatric+Endocrinology+%26+Metabolism&atitle=Triglyceride%2Fglucose+index+is+a+reliable+alternative+marker+for+insulin+resistance+in+South+American+overweight+and+obese+children+and+adolescents.&volume=32&issue=10&spage=1163&epage=1170&date=2019&doi=10.1515%2Fjpem-2019-0037&pmid=31472061&sid=OVID:medline
+
+<2047>
+Unique Identifier
+ 31469122
+Title
+ Serum pentraxin 3 concentration in patients with type 2 diabetes and nonalcoholic fatty liver disease.
+Source
+ Polish Archives Of Internal Medicine. 129(7-8):499-505, 2019 08 29.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Trojak A; Walus-Miarka M; Kapusta M; Miarka P; Kawalec E; Idzior-Walus B; Malecki MT
+Authors Full Name
+ Trojak, Aleksandra; Walus-Miarka, Malgorzata; Kapusta, Maria; Miarka, Przemyslaw; Kawalec, Ewa; Idzior-Walus, Barbara; Malecki, Maciej T.
+Institution
+ Trojak, Aleksandra. Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
+ Walus-Miarka, Malgorzata. Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
+ Walus-Miarka, Malgorzata. Department of Metabolic Diseases, University Hospital, Krakow, Poland
+ Kapusta, Maria. Department of Biochemistry, Jagiellonian University Medical College, Krakow, Poland
+ Miarka, Przemyslaw. Department of Metabolic Diseases, University Hospital, Krakow, Poland
+ Miarka, Przemyslaw. Department of Nephrology, Jagiellonian University Medical College, Krakow, Poland
+ Kawalec, Ewa. Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
+ Idzior-Walus, Barbara. Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
+ Idzior-Walus, Barbara. Department of Metabolic Diseases, University Hospital, Krakow, Poland
+ Malecki, Maciej T. Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
+ Malecki, Maciej T. Department of Metabolic Diseases, University Hospital, Krakow, Poland
+Comments
+ Comment in (CIN)
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ *C-Reactive Protein/me [Metabolism]
+ Case-Control Studies
+ Cholesterol, LDL/me [Metabolism]
+ Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Humans
+ *Insulin Resistance
+ Male
+ Middle Aged
+ Non-alcoholic Fatty Liver Disease/co [Complications]
+ *Non-alcoholic Fatty Liver Disease/me [Metabolism]
+ Obesity/me [Metabolism]
+ *Serum Amyloid P-Component/me [Metabolism]
+ Severity of Illness Index
+Abstract
+ INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is common in patients with type 2 diabetes (T2D). Pentraxin 3 (PTX3), a marker of inflammation, is a cardiovascular risk factor.
+
+ OBJECTIVES: We examined clinical and biochemical factors associated with serum PTX3 concentrations in patients with T2D with and without NAFLD.
+
+ PATIENTS AND METHODS: Serum material was obtained from 116 patients with T2D (mean age, 59.1 years), including 79 patients with NAFLD.
+
+ RESULTS: Median (interquartile range) PTX3 level was 4.264 (2.293) ng/ml in patients with and 3.773 (3.223) ng/ml in patients without NAFLD (P = 0.93). In the whole group, PTX3 level was associated with total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein (apo) B100, apo C3, triglyceride (TG) concentrations, and waist circumference after adjustment for age and gender. As indicated by partial regression coefficient b, increase of independent variable LDL-C by 1 mmol/l was associated with the rise of PTX3 by 1.2017 ng/ml, increase of apo B100 by 1 mg/dl with the rise of PTX3 by 1.0051 ng/ml, and increase of apo C3 by 1 mug/dl with the rise of PTX3 by 1.0012 ng/ml. In patients with T2D with NAFLD, total cholesterol, LDL-C, TG, apo C3, and apo B100 were associated with PTX3. Associations of PTX3 with apolipoproteins were observed only in the NAFLD group.
+
+ CONCLUSIONS: Reported associations of PTX3 level add new insight into possible mechanisms of its atherogenic actions.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Cholesterol, LDL). 0 (Serum Amyloid P-Component). 148591-49-5 (PTX3 protein). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.20452%2fpamw.14913
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Trojak&issn=0032-3772&title=Polish+Archives+Of+Internal+Medicine&atitle=Serum+pentraxin+3+concentration+in+patients+with+type+2+diabetes+and+nonalcoholic+fatty+liver+disease.&volume=129&issue=7-8&spage=499&epage=505&date=2019&doi=10.20452%2Fpamw.14913&pmid=31469122&sid=OVID:medline
+
+<2048>
+Unique Identifier
+ 31468305
+Title
+ Metabolic Features of Individuals with Obesity Referred for Bariatric and Metabolic Surgery: a Cohort Study.
+Source
+ Obesity Surgery. 29(12):3966-3977, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Li M; Liu Y; Jin L; Zeng N; Wang L; Zhao K; Lv H; Zhang M; Xu W; Zhang P; Zhang Z
+Author NameID
+ Zhang, Zhongtao; ORCID: http://orcid.org/0000-0002-4718-6821
+Authors Full Name
+ Li, Mengyi; Liu, Yang; Jin, Lan; Zeng, Na; Wang, Lixue; Zhao, Kaixin; Lv, Han; Zhang, Meng; Xu, Wei; Zhang, Peng; Zhang, Zhongtao.
+Institution
+ Li, Mengyi. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Liu, Yang. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Jin, Lan. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Zeng, Na. National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Wang, Lixue. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Zhao, Kaixin. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Lv, Han. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Zhang, Meng. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Xu, Wei. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Zhang, Peng. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
+ Zhang, Zhongtao. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China. zhangzht@ccmu.edu.cn.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Bariatric Surgery
+ Biomarkers/me [Metabolism]
+ C-Peptide/me [Metabolism]
+ Cohort Studies
+ Cross-Sectional Studies
+ Female
+ Humans
+ Hypertension/di [Diagnosis]
+ Hypertension/et [Etiology]
+ Insulin/me [Metabolism]
+ Linear Models
+ Lipid Metabolism
+ Male
+ Middle Aged
+ *Obesity/di [Diagnosis]
+ *Obesity/me [Metabolism]
+ Obesity/pp [Physiopathology]
+ Obesity/su [Surgery]
+ *Phenotype
+ Risk Factors
+ Uric Acid/me [Metabolism]
+ Young Adult
+Keyword Heading
+ Bariatric and metabolic surgery
+ Metabolic phenotype
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The concept of metabolic obesity phenotypes has been proposed, but its relevance to metabolic features is unclear.
+
+ PURPOSE: To determine a new definition of metabolic obesity phenotype, investigate the characteristics of expressing clustered normal and abnormal metabolic parameters, and analyze factors associated with metabolic abnormalities.
+
+ MATERIALS AND METHODS: Characteristics of 600 patients were analyzed. The definition of metabolic obesity phenotype includes elevated blood pressure, glucose, lipid, and uric acid levels and abnormal lipoprotein levels. Independent sample t test and a general linear model with repeated measures were applied to investigate the differences in metabolic parameters.
+
+ RESULTS: A total of 108 (18.0%) participants were obese yet metabolically healthy, whereas 492 (82.0%) were obese and metabolically unhealthy. Body weight at baseline was significantly higher in metabolically unhealthy phenotype (P < 0.001). For non-phasic oral glucose tolerance test (OGTT) curve shape, 100% glucose, 100% C-peptide, and 95.8% insulin curves were found in the metabolically unhealthy group. Men had an increased risk for elevated lipid level than women (OR = 1.83, 1.21-2.77). Individuals with class II/III obesity had an increased risk for elevated blood pressure, glucose, and UA levels than did those with class I obesity (OR = 2.22, 1.43-3.44; OR = 1.73, 1.11-2.68; OR = 3.61, 2.29-5.69, respectively).
+
+ CONCLUSIONS: Approximately one-fifth of individuals with obesity had a metabolically healthy phenotype, and nearly one-third of individuals with class III obesity had this phenotype. Non-phasic OGTT curve shape is a meaningful predictive factor of metabolically unhealthy phenotype before bariatric surgery. Male sex and class II/III obesity are risk factors associated with specific metabolic abnormalities.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (C-Peptide). 0 (Insulin). 268B43MJ25 (Uric Acid).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1007%2fs11695-019-04067-0
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Li&issn=0960-8923&title=Obesity+Surgery&atitle=Metabolic+Features+of+Individuals+with+Obesity+Referred+for+Bariatric+and+Metabolic+Surgery%3A+a+Cohort+Study.&volume=29&issue=12&spage=3966&epage=3977&date=2019&doi=10.1007%2Fs11695-019-04067-0&pmid=31468305&sid=OVID:medline
+
+<2049>
+Unique Identifier
+ 31466276
+Title
+ Racial Variations in Appetite-Related Hormones, Appetite, and Laboratory-Based Energy Intake from the E-MECHANIC Randomized Clinical Trial.
+Source
+ Nutrients. 11(9), 2019 Aug 28.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Dorling JL; Church TS; Myers CA; Hochsmann C; White UA; Hsia DS; Martin CK; Apolzan JW
+Author NameID
+ Myers, Candice A; ORCID: https://orcid.org/0000-0003-1923-3448
+ Hochsmann, Christoph; ORCID: https://orcid.org/0000-0003-2007-3007
+ White, Ursula A; ORCID: https://orcid.org/0000-0003-2926-9882
+ Martin, Corby K; ORCID: https://orcid.org/0000-0002-8125-4015
+ Apolzan, John W; ORCID: https://orcid.org/0000-0001-8492-7820
+Authors Full Name
+ Dorling, James L; Church, Timothy S; Myers, Candice A; Hochsmann, Christoph; White, Ursula A; Hsia, Daniel S; Martin, Corby K; Apolzan, John W.
+Institution
+ Dorling, James L. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
+ Church, Timothy S. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
+ Myers, Candice A. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
+ Hochsmann, Christoph. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
+ White, Ursula A. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
+ Hsia, Daniel S. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
+ Martin, Corby K. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Corby.Martin@pbrc.edu.
+ Apolzan, John W. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA. John.Apolzan@pbrc.edu.
+MeSH Subject Headings
+ Adult
+ *Black or African American
+ *Appetite Regulation/eh [Ethnology]
+ Biomarkers/bl [Blood]
+ *Energy Intake/eh [Ethnology]
+ Female
+ Ghrelin/bl [Blood]
+ *Health Status Disparities
+ Humans
+ Leptin/bl [Blood]
+ Louisiana/ep [Epidemiology]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/eh [Ethnology]
+ Obesity/pp [Physiopathology]
+ *Peptide Hormones/bl [Blood]
+ Peptide YY/bl [Blood]
+ Postprandial Period
+ Time Factors
+ *White People
+Keyword Heading
+ body composition
+ energy intake
+ exercise
+ food intake
+ health disparities
+ physical activity
+ race
+ satiety
+ satiety quotient
+ visual analogue scales
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ African Americans (AAs) have a higher obesity risk than Whites; however, it is unclear if appetite-related hormones and food intake are implicated. We examined differences in appetite-related hormones, appetite, and food intake between AAs (n = 53) and Whites (n = 111) with overweight or obesity. Participants were randomized into a control group or into supervised, controlled exercise groups at 8 kcal/kg of body weight/week (KKW) or 20 KKW. Participants consumed lunch and dinner at baseline and follow-up, with appetite and hormones measured before and after meals (except leptin). At baseline, AAs had lower peptide YY (PYY; p < 0.01) and a blunted elevation in PYY after lunch (p = 0.01), as well as lower ghrelin (p = 0.02) and higher leptin (p < 0.01) compared to Whites. Despite desire to eat being lower and satisfaction being higher in AAs relative to Whites (p <= 0.03), no racial differences in food intake were observed. Compared to Whites, leptin increased in the 8 KKW group in AAs (p = 0.01), yet no other race-by-group interactions were evident. Differences in appetite-related hormones between AAs and Whites exist; however, their influence on racial disparities in appetite, food intake, and obesity within this trial was limited.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (GHRL protein, human). 0 (Ghrelin). 0 (LEP protein, human). 0 (Leptin). 0 (Peptide Hormones). 106388-42-5 (Peptide YY).
+Publication Type
+ Comparative Study. Journal Article. Randomized Controlled Trial.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11092018
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Dorling&issn=2072-6643&title=Nutrients&atitle=Racial+Variations+in+Appetite-Related+Hormones%2C+Appetite%2C+and+Laboratory-Based+Energy+Intake+from+the+E-MECHANIC+Randomized+Clinical+Trial.&volume=11&issue=9&spage=&epage=&date=2019&doi=10.3390%2Fnu11092018&pmid=31466276&sid=OVID:medline
+
+<2050>
+Unique Identifier
+ 31465301
+Title
+ Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients.
+Source
+ Jci Insight. 4(19), 2019 10 03.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hankir MK; Rullmann M; Seyfried F; Preusser S; Poppitz S; Heba S; Gousias K; Hoyer J; Schutz T; Dietrich A; Muller K; Pleger B
+Authors Full Name
+ Hankir, Mohammed K; Rullmann, Michael; Seyfried, Florian; Preusser, Sven; Poppitz, Sindy; Heba, Stefanie; Gousias, Konstantinos; Hoyer, Jana; Schutz, Tatjana; Dietrich, Arne; Muller, Karsten; Pleger, Burkhard.
+Institution
+ Hankir, Mohammed K. Department of Experimental Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
+ Rullmann, Michael. IFB AdiposityDiseases and.
+ Rullmann, Michael. Department of Nuclear Medicine, University Hospital Leipzig, Germany.
+ Rullmann, Michael. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
+ Rullmann, Michael. Collaborative Research Centre 1052 in Obesity Mechanisms, University of Leipzig, Leipzig, Germany.
+ Seyfried, Florian. Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
+ Preusser, Sven. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
+ Poppitz, Sindy. IFB AdiposityDiseases and.
+ Poppitz, Sindy. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
+ Heba, Stefanie. Department of Neurology and.
+ Gousias, Konstantinos. Department of Neurosurgery, BG University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany.
+ Hoyer, Jana. Department of Behavioral Epidemiology, Department of Psychology, Technische Universitat Dresden, Dresden, Germany.
+ Schutz, Tatjana. IFB AdiposityDiseases and.
+ Dietrich, Arne. IFB AdiposityDiseases and.
+ Dietrich, Arne. Department of Bariatric Surgery, University Hospital Leipzig, Leipzig, Germany.
+ Muller, Karsten. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
+ Pleger, Burkhard. IFB AdiposityDiseases and.
+ Pleger, Burkhard. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
+ Pleger, Burkhard. Collaborative Research Centre 1052 in Obesity Mechanisms, University of Leipzig, Leipzig, Germany.
+ Pleger, Burkhard. Department of Neurology and.
+MeSH Subject Headings
+ Adipose Tissue
+ Adult
+ Biomarkers
+ Blood Glucose
+ C-Reactive Protein
+ Diabetes Mellitus
+ Female
+ *Gastric Bypass/mt [Methods]
+ Humans
+ Hypothalamus/dg [Diagnostic Imaging]
+ *Hypothalamus/me [Metabolism]
+ Inflammation/dg [Diagnostic Imaging]
+ *Inflammation/me [Metabolism]
+ Insulin/me [Metabolism]
+ Male
+ Middle Aged
+ Obesity
+ *Obesity, Morbid/su [Surgery]
+Keyword Heading
+ Metabolism
+ Neuroimaging
+ Neuroscience
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ There is increased interest in whether bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) achieve their profound weight-lowering effects in morbidly obese individuals through the brain. Hypothalamic inflammation is a well-recognized etiologic factor in obesity pathogenesis and so represents a potential target of RYGB, but clinical evidence in support of this is limited. We therefore assessed hypothalamic T2-weighted signal intensities (T2W SI) and fractional anisotropy (FA) values, 2 validated radiologic measures of brain inflammation, in relation to BMI and fat mass, as well as circulating inflammatory (C-reactive protein; CrP) and metabolic markers in a cohort of 27 RYGB patients at baseline and 6 and 12 months after surgery. We found that RYGB progressively increased hypothalamic T2W SI values, while it progressively decreased hypothalamic FA values. Regression analyses further revealed that this could be most strongly linked to plasma CrP levels, which independently predicted hypothalamic FA values when adjusting for age, sex, fat mass, and diabetes diagnosis. These findings suggest that RYGB has a major time-dependent impact on hypothalamic inflammation status, possibly by attenuating peripheral inflammation. They also suggest that hypothalamic FA values may provide a more specific radiologic measure of hypothalamic inflammation than more commonly used T2W SI values.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Insulin). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1172%2fjci.insight.131329
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hankir&issn=2379-3708&title=Jci+Insight&atitle=Roux-en-Y+gastric+bypass+surgery+progressively+alters+radiologic+measures+of+hypothalamic+inflammation+in+obese+patients.&volume=4&issue=19&spage=&epage=&date=2019&doi=10.1172%2Fjci.insight.131329&pmid=31465301&sid=OVID:medline
+
+<2051>
+Unique Identifier
+ 31455303
+Title
+ An in-depth analysis of glycosylated haemoglobin level, body mass index and left ventricular diastolic dysfunction in patients with type 2 diabetes.
+Source
+ BMC Endocrine Disorders. 19(1):88, 2019 Aug 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Zuo X; Liu X; Chen R; Ou H; Lai J; Zhang Y; Yan D
+Author NameID
+ Zhang, Youming; ORCID: http://orcid.org/0000-0001-5403-4044
+Authors Full Name
+ Zuo, Xin; Liu, Xueting; Chen, Runtian; Ou, Huiting; Lai, Jiabao; Zhang, Youming; Yan, Dewen.
+Institution
+ Zuo, Xin. Department of Endocrinology, Xiangya-Shenzhen Endocrinology and Metabolism Center, the First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.
+ Liu, Xueting. Department of Endocrinology, Xiangya-Shenzhen Endocrinology and Metabolism Center, the First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.
+ Chen, Runtian. Department of Endocrinology, Xiangya-Shenzhen Endocrinology and Metabolism Center, the First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.
+ Ou, Huiting. Department of Endocrinology, Xiangya-Shenzhen Endocrinology and Metabolism Center, the First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.
+ Lai, Jiabao. Department of Endocrinology, Xiangya-Shenzhen Endocrinology and Metabolism Center, the First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.
+ Zhang, Youming. Genomic and Environmental Medicine Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK. y.zhang@imperial.ac.uk.
+ Yan, Dewen. Department of Endocrinology, Xiangya-Shenzhen Endocrinology and Metabolism Center, the First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China. yandw963@126.com.
+MeSH Subject Headings
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ *Body Mass Index
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/co [Complications]
+ Female
+ Follow-Up Studies
+ *Glycated Hemoglobin/an [Analysis]
+ Humans
+ Incidence
+ Male
+ Middle Aged
+ Obesity/pp [Physiopathology]
+ Overweight/pp [Physiopathology]
+ Prognosis
+ Risk Factors
+ Taiwan/ep [Epidemiology]
+ Ventricular Dysfunction, Left/bl [Blood]
+ *Ventricular Dysfunction, Left/ep [Epidemiology]
+ Ventricular Dysfunction, Left/et [Etiology]
+Keyword Heading
+ Body mass index
+ Glycosylated haemoglobin
+ Left ventricular diastolic dysfunction
+ Type 2 diabetes
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Glycosylated hemoglobin (HbA1c) has a detrimental impact on the myocardium with left ventricular (LV) diastolic dysfunction. Obesity is a risk factor of type 2 diabetes. To understand the relationships between HbA1c, body mass index (BMI) and LV diastolic dysfunction, we performed this interaction analysis in patients with type 2 diabetes.
+
+ METHODS: Total 925 type 2 diabetes patients were selected from the patients who were diagnosed and treated at the First Affiliated Hospital of Shenzhen University. Patients' BMI levels were defined as normal (BMI < 24 kg/m2) and overweight /obese (BMI >= 24 kg/m2). Patients' HbA1c levels were grouped as HbA1c >= 9% 7% <= HbA1c < 9% and HbA1c < 7%. Logistic regression, stratified, interaction analysis, multivariate Cox regression and curve fitting analysis were performed to investigate the correlations and interactions between HbA1c and BMI with LV diastolic dysfunction.
+
+ RESULTS: The BMI levels were significantly associated with LV diastolic dysfunction in the patients with type 2 diabetes [adjusted model: 1.12 (1.05, 1.20), P = 0.001]. While HbA1c levels had association with LV diastolic dysfunction only in normal BMI group patients [adjusted model: 1.14 (1.01, 1.30), P = 0.0394] and curve correlation was observed. There was a significant interaction between BMI and HbA1c to affect LV diastolic dysfunction (P = 0.0335). Cox regression model analysis showed that the risk of LV diastolic dysfunction was a U type correlation with HbA1c levels in the normal weight group and the turning point was HbA1c at 10%. HbA1c level was not found to have a significant association with LV diastolic dysfunction in overweight/obese group.
+
+ CONCLUSIONS: In patients with type 2 diabetes, correlation between LV diastolic dysfunction and HbA1c was interactively affected by BMI. Glycemic control is beneficial to the heart function in normal body weight patients. For overweight/obese patients, the risk of LV diastolic dysfunction was not determined by the HbA1c level, indicating it may be affected by other confounding factors.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12902-019-0419-7
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Zuo&issn=1472-6823&title=BMC+Endocrine+Disorders&atitle=An+in-depth+analysis+of+glycosylated+haemoglobin+level%2C+body+mass+index+and+left+ventricular+diastolic+dysfunction+in+patients+with+type+2+diabetes.&volume=19&issue=1&spage=88&epage=&date=2019&doi=10.1186%2Fs12902-019-0419-7&pmid=31455303&sid=OVID:medline
+
+<2052>
+Unique Identifier
+ 31455254
+Title
+ Body composition is a strong predictor of local carotid stiffness in Swedish, young adults - the cross sectional Lifestyle, biomarkers, and atherosclerosis study.
+Source
+ BMC Cardiovascular Disorders. 19(1):205, 2019 08 27.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Fernberg U; Op 't Roodt J; Fernstrom M; Hurtig-Wennlof A
+Author NameID
+ Fernberg, Ulrika; ORCID: https://orcid.org/0000-0002-6520-9265
+Authors Full Name
+ Fernberg, Ulrika; Op 't Roodt, Jos; Fernstrom, Maria; Hurtig-Wennlof, Anita.
+Institution
+ Fernberg, Ulrika. Cardiovascular Research Center, Faculty of Medicine and Health, Orebro University, Orebro, Sweden. ulrika.fernberg@oru.se.
+ Fernberg, Ulrika. School of Health Sciences, Orebro University, Fakultetsgatan 1, 701 82, Orebro, SE, Sweden. ulrika.fernberg@oru.se.
+ Op 't Roodt, Jos. Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
+ Op 't Roodt, Jos. CARIM, School for Cardiovascular Diseases, Maastricht, The Netherlands.
+ Fernstrom, Maria. Astrand Laboratory of Work Physiology, Swedish School of Sport and Health Sciences, GIH, Stockholm, Sweden.
+ Hurtig-Wennlof, Anita. Cardiovascular Research Center, Faculty of Medicine and Health, Orebro University, Orebro, Sweden.
+MeSH Subject Headings
+ *Adiposity
+ Adolescent
+ Adult
+ Age Factors
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Carotid Arteries/dg [Diagnostic Imaging]
+ *Carotid Arteries/pp [Physiopathology]
+ Carotid Artery Diseases/bl [Blood]
+ Carotid Artery Diseases/dg [Diagnostic Imaging]
+ Carotid Artery Diseases/ep [Epidemiology]
+ *Carotid Artery Diseases/pp [Physiopathology]
+ Carotid Intima-Media Thickness
+ Cross-Sectional Studies
+ Elastic Modulus
+ Female
+ Humans
+ *Life Style
+ Male
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Risk Assessment
+ Risk Factors
+ Sex Factors
+ Sweden/ep [Epidemiology]
+ *Vascular Stiffness
+ Waist Circumference
+ Young Adult
+Keyword Heading
+ Arterial distensibility
+ Arterial stiffness
+ Body composition
+ Carotid artery
+ Cross-sectional study
+ Epidemiological
+ Intima media thickness
+ Young adults
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Obesity has nearly tripled worldwide during the last four decades, especially in young adults, and is of growing concern since it is a risk factor for cardiovascular diseases (CVD). We explored how different body composition measurements are associated with intima media thickness (cIMT) and local stiffness in the common carotid artery, in a subsample of healthy, young women and men, from the Swedish Lifestyle, Biomarkers, and Atherosclerosis (LBA) Study.
+
+ METHODS: From the LBA study, a subsample of 220 randomly selected, self-reported healthy individuals, 18-25 years old, were collected for the automatized local stiffness measurements; arterial distensibility, Young's elastic modulus, and beta stiffness index. Blood pressure and mean arterial pressure (MAP) was measured using automatic blood pressure equipment. Body mass index (BMI) was calculated, waist circumference was measured, and percentage of body fat assessed using an impedance body composition analyzer. The carotid artery was scanned by ultrasound and analyzed using B-mode edge wall tracking. cIMT was measured and local stiffness measurements were calculated with carotid blood pressure, measured with applanation tonometry.
+
+ RESULTS: No association was found between cIMT and body composition. Local carotid stiffness was associated with body composition, and women had less stiff arteries than men (p < 0.001). Of the local stiffness measurements, arterial distensibility had the strongest associations with body composition measurements in both women and men (p < 0.05). Multiple regression analyses showed that BMI in women and BMI and percentage of body fat in men had the highest impact on arterial distensibility (p < 0.01 in both women and men).
+
+ CONCLUSIONS: Arterial distensibility was the local stiffness measurement with the strongest associations to different body composition measurements, in both women and men. In this age group, body composition measurements seem to be stronger predictors of common carotid arterial stiffness than MAP, and is a convenient way of detecting young adults who need cardiovascular risk follow-up and lifestyle counseling.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1186%2fs12872-019-1180-6
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Fernberg&issn=1471-2261&title=BMC+Cardiovascular+Disorders&atitle=Body+composition+is+a+strong+predictor+of+local+carotid+stiffness+in+Swedish%2C+young+adults+-+the+cross+sectional+Lifestyle%2C+biomarkers%2C+and+atherosclerosis+study.&volume=19&issue=1&spage=205&epage=&date=2019&doi=10.1186%2Fs12872-019-1180-6&pmid=31455254&sid=OVID:medline
+
+<2053>
+Unique Identifier
+ 31455100
+Title
+ Osteocalcin and epicardial adipose tissue in obesity: new hints for epicardial adipose tissue-bone crosstalk.
+Source
+ Scandinavian Cardiovascular Journal. 53(6):296-298, 2019 Dec.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Yaylali YT; Fidan-Yaylali G; Dedeoglu O; Senol H
+Authors Full Name
+ Yaylali, Yalin Tolga; Fidan-Yaylali, Guzin; Dedeoglu, Ozen; Senol, Hande.
+Institution
+ Yaylali, Yalin Tolga. Department of Cardiology, Pamukkale University, Faculty of Medicine, Denizli, Turkey.
+ Fidan-Yaylali, Guzin. Department of Endocrinology and Metabolic Diseases, Pamukkale University, Faculty of Medicine, Denizli, Turkey.
+ Dedeoglu, Ozen. Department of Hematology, Marmara University Training and Research Hospital, Istanbul, Turkey.
+ Senol, Hande. Department of Biostatistics, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
+MeSH Subject Headings
+ Adipose Tissue/dg [Diagnostic Imaging]
+ *Adipose Tissue/pp [Physiopathology]
+ *Adiposity
+ Biomarkers/bl [Blood]
+ *Bone and Bones/me [Metabolism]
+ Case-Control Studies
+ Down-Regulation
+ Female
+ Humans
+ *Obesity/bl [Blood]
+ Obesity/dg [Diagnostic Imaging]
+ *Obesity/pp [Physiopathology]
+ *Osteocalcin/bl [Blood]
+ Pericardium
+ Premenopause/bl [Blood]
+Keyword Heading
+ Epicardial adipose tissue
+ obesity
+ osteocalcin
+ premenopausal obese women
+ prevention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objectives: Osteocalcin (OC) appears to be involved in the regulation of glucose and fat metabolism. We aimed to determine the association between OC and epicardial adipose tissue (EAT) in premenopausal obese women. Design: The study included 73 premenopausal obese women and 55 non-obese women. Echocardiographic examination was performed to measure EAT. Serum OC levels were measured by chemiluminescence immunoassay. Results: OC levels were significantly lower in obese women than controls (18.26 +/- 5.27 vs. 22.53 +/- 6.84 ng/ml, p < .001). EAT thickness was higher in obese women than controls (5.19 +/- 0.73 vs. 3.25 +/- 1.35 mm, p < .001). In obese women, OC was positively correlated with EAT thickness (p = .043; r = 0.326). There was no correlation in controls. Conclusions: Premenopausal obese women had lower OC levels and thicker EAT than controls. There was a weak positive correlation between OC and EAT in premenopausal obese women. This potential cross talk between bone metabolism and EAT could play a role in the development of atherosclerosis in obesity.
+Registry Number/Name of Substance
+ 0 (BGLAP protein, human). 0 (Biomarkers). 104982-03-8 (Osteocalcin).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1080%2f14017431.2019.1659397
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Yaylali&issn=1401-7431&title=Scandinavian+Cardiovascular+Journal&atitle=Osteocalcin+and+epicardial+adipose+tissue+in+obesity%3A+new+hints+for+epicardial+adipose+tissue-bone+crosstalk.&volume=53&issue=6&spage=296&epage=298&date=2019&doi=10.1080%2F14017431.2019.1659397&pmid=31455100&sid=OVID:medline
+
+<2054>
+Unique Identifier
+ 31446069
+Title
+ Short communication: Adipogenic, metabolic, and apoptotic marker mRNA in cellular fractions of adipose tissue from chickens predisposed to be anorexic or obese.
+Source
+ Comparative Biochemistry & Physiology. Part A, Molecular & Integrative Physiology. 238:110555, 2019 12.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Xiao Y; Siegel PB; Cline MA; Gilbert ER
+Authors Full Name
+ Xiao, Yang; Siegel, Paul B; Cline, Mark A; Gilbert, Elizabeth R.
+Institution
+ Xiao, Yang. Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
+ Siegel, Paul B. Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
+ Cline, Mark A. Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
+ Gilbert, Elizabeth R. Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Electronic address: egilbert@vt.edu.
+MeSH Subject Headings
+ *Adipogenesis/ge [Genetics]
+ *Adipose Tissue/me [Metabolism]
+ Animals
+ *Anorexia/ge [Genetics]
+ *Apoptosis/ge [Genetics]
+ *Biomarkers/me [Metabolism]
+ Caspase 3/ge [Genetics]
+ Caspase 3/me [Metabolism]
+ *Chickens/ge [Genetics]
+ *Genetic Predisposition to Disease
+ Granzymes/ge [Genetics]
+ Granzymes/me [Metabolism]
+ *Obesity/ge [Genetics]
+ RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+Keyword Heading
+ Adipocytes
+ Apoptosis
+ Chicken
+ Development
+ Stromal-vascular fraction
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ The body weight-selected lines of chickens are a model for understanding factors that predispose an individual to anorexia or obesity. The high body weight-selected (HWS) individuals are compulsive eaters that become obese whereas the low body weight-selected (LWS) are relatively lean and hypophagic. The objective of this study was to measure gene expression of various preadipocyte, proliferation, metabolic, and apoptotic markers in the stromal-vascular fraction and adipocytes from LWS and HWS adipose tissue. Although preadipocyte and proliferation markers were more highly expressed in the stromal-vascular fraction of LWS than HWS chicks, greater expression of granzyme-A and the presence of more annexin V-positive cells suggests that apoptosis may limit the adipogenic potential of adipocyte precursor cells and represent a novel mechanism that regulates the expansion of adipose tissue. Results provide insights on cellular mechanisms associated with adipose tissue development in the lean and obese state. Copyright © 2019 Elsevier Inc. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (RNA, Messenger). EC 3-4-21 (Granzymes). EC 3-4-22 (Caspase 3).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.cbpa.2019.110555
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Xiao&issn=1095-6433&title=Comparative+Biochemistry+%26+Physiology.+Part+A%2C+Molecular+%26+Integrative+Physiology&atitle=Short+communication%3A+Adipogenic%2C+metabolic%2C+and+apoptotic+marker+mRNA+in+cellular+fractions+of+adipose+tissue+from+chickens+predisposed+to+be+anorexic+or+obese.&volume=238&issue=&spage=110555&epage=&date=2019&doi=10.1016%2Fj.cbpa.2019.110555&pmid=31446069&sid=OVID:medline
+
+<2055>
+Unique Identifier
+ 31443510
+Title
+ Differences in Serum Magnesium Levels in Diabetic and Non-Diabetic Patients Following One-Anastomosis Gastric Bypass.
+Source
+ Nutrients. 11(9), 2019 Aug 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Winzer E; Grabovac I; Ludvik B; Kruschitz R; Schindler K; Prager G; Klammer C; Smith L; Hoppichler F; Marculescu R; Wakolbinger M
+Authors Full Name
+ Winzer, Eva; Grabovac, Igor; Ludvik, Bernhard; Kruschitz, Renate; Schindler, Karin; Prager, Gerhard; Klammer, Carmen; Smith, Lee; Hoppichler, Friedrich; Marculescu, Rodrig; Wakolbinger, Maria.
+Institution
+ Winzer, Eva. Department of Social and Preventive Medicine, Centre for Public Health, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
+ Grabovac, Igor. Department of Social and Preventive Medicine, Centre for Public Health, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. igor.grabovac@meduniwien.ac.at.
+ Ludvik, Bernhard. Department of Medicine 1 and Karl Landsteiner Institute for Obesity and Metabolic Disorders, Rudolfstiftung Hospital, Juchgasse 25, 1030 Vienna, Austria.
+ Kruschitz, Renate. Division of Internal Medicine, General Public Hospital of the Order of Saint Elisabeth, Volkermarkter Strase 15-19, 9020 Klagenfurt, Austria.
+ Kruschitz, Renate. Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
+ Schindler, Karin. Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
+ Prager, Gerhard. Division of General Surgery, Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
+ Klammer, Carmen. Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
+ Klammer, Carmen. Department of Internal Medicine, Convent of the Brothers of Saint John of God, Seilerstatte 2, 4021 Linz, Austria.
+ Smith, Lee. Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK.
+ Hoppichler, Friedrich. Special Institute for Preventive Cardiology and Nutrition-SIPCAN, Rabenfleckweg 8, 5061 Salzburg, Austria.
+ Hoppichler, Friedrich. Division of Internal Medicine, Krankenhaus der Barmherzigen Bruder, Kajetanerplatz 1, 5010 Salzburg, Austria.
+ Marculescu, Rodrig. Clinical Institute for Medical and Chemical Laboratory Diagnostics, Department of Laboratory Medicine, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
+ Wakolbinger, Maria. Department of Social and Preventive Medicine, Centre for Public Health, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
+ Wakolbinger, Maria. Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
+ Wakolbinger, Maria. Special Institute for Preventive Cardiology and Nutrition-SIPCAN, Rabenfleckweg 8, 5061 Salzburg, Austria.
+MeSH Subject Headings
+ Adult
+ Biomarkers/bl [Blood]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Female
+ *Gastric Bypass
+ Humans
+ *Magnesium/bl [Blood]
+ *Magnesium Deficiency/bl [Blood]
+ Magnesium Deficiency/di [Diagnosis]
+ Male
+ Middle Aged
+ Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ *Obesity/su [Surgery]
+ Randomized Controlled Trials as Topic
+ Time Factors
+ Treatment Outcome
+ Young Adult
+Keyword Heading
+ obesity
+ one anastomosis gastric bypass
+ serum magnesium
+ type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Patients with obesity and type 2 diabetes mellitus (T2DM) are regarded to have reduced serum magnesium (Mg) concentrations. We aimed to assess the changes in serum Mg concentrations at 12-month follow-up in patients, with and without T2DM, who underwent one anastomosis gastric bypass surgery. Overall, 50 patients (80% female, age 42.2 (12.5) years) with morbid obesity (mean baseline BMI 43.8 (4.3) kg/m2) were included in the analysis. Half of the included patients had T2DM diagnosed at baseline, and these patients showed lower serum Mg concentration (0.78 (0.07)) vs. 0.83 (0.05) mmol/L; p = 0.006), higher blood glucose levels (129.9 (41.3) vs. 87.6 (8.1) mg/dL; p < 0.001) as well as HbA1c concentrations (6.7 (1.4) vs. 5.3 (0.5)%; p < 0.001). During follow-up, BMI and glucose levels showed a decrease; however, serum Mg levels remained stable. At baseline 42% of patients were found to be Mg deficient, which was reduced to 33% at six months and to 30% at 12 months follow-up. Moreover, patients with T2DM had an odds ratio of 9.5 (95% CI = 3.0-29.7; p < 0.001) for magnesium deficiency when compared to patients without T2DM. Further research into the role of Mg and its role in T2DM and other obesity-related comorbidities are needed.
+Registry Number/Name of Substance
+ 0 (Biomarkers). I38ZP9992A (Magnesium).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11091984
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Winzer&issn=2072-6643&title=Nutrients&atitle=Differences+in+Serum+Magnesium+Levels+in+Diabetic+and+Non-Diabetic+Patients+Following+One-Anastomosis+Gastric+Bypass.&volume=11&issue=9&spage=&epage=&date=2019&doi=10.3390%2Fnu11091984&pmid=31443510&sid=OVID:medline
+
+<2056>
+Unique Identifier
+ 31443387
+Title
+ No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women.
+Source
+ Nutrients. 11(9), 2019 Aug 22.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Jamka M; Krzyzanowska-Jankowska P; Madry E; Lisowska A; Bogdanski P; Walkowiak J
+Author NameID
+ Walkowiak, Jaroslaw; ORCID: https://orcid.org/0000-0001-5813-5707
+Authors Full Name
+ Jamka, Malgorzata; Krzyzanowska-Jankowska, Patrycja; Madry, Edyta; Lisowska, Aleksandra; Bogdanski, Pawel; Walkowiak, Jaroslaw.
+Institution
+ Jamka, Malgorzata. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznan, Poland.
+ Krzyzanowska-Jankowska, Patrycja. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznan, Poland.
+ Madry, Edyta. Department of Physiology, Poznan University of Medical Sciences, Swiecickiego Str. 6, 60-781 Poznan, Poland.
+ Lisowska, Aleksandra. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznan, Poland.
+ Bogdanski, Pawel. Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego Str. 84, 60-569 Poznan, Poland.
+ Walkowiak, Jaroslaw. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznan, Poland. jarwalk@ump.edu.pl.
+MeSH Subject Headings
+ Adiposity
+ Biomarkers/bl [Blood]
+ Body Mass Index
+ Body Weight
+ *Energy Metabolism
+ Female
+ Humans
+ *Lactoferrin/bl [Blood]
+ Middle Aged
+ *Obesity/bl [Blood]
+ Obesity/di [Diagnosis]
+ Obesity/pp [Physiopathology]
+ *Obesity, Metabolically Benign/bl [Blood]
+ Obesity, Metabolically Benign/di [Diagnosis]
+ Obesity, Metabolically Benign/pp [Physiopathology]
+ Waist Circumference
+Keyword Heading
+ lactoferrin
+ metabolic syndrome
+ metabolically healthy obesity
+ metabolically unhealthy obesity
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The aim of the study was to compare serum lactoferrin concentrations in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) women.
+
+ METHODS: Three hundred (101 MHO and 199 MUHO) women were recruited to the study. Basic anthropometric parameters and blood pressure were measured. Body mass index (BMI) was calculated. Fat mass and visceral adipose tissue mass were assessed using dual X-ray absorptiometry scan. Fasting glucose, insulin, lipid profile, high sensitivity C-reactive protein (hs-CRP) and lactoferrin levels were determined.
+
+ RESULTS: Lactoferrin levels did not differ between MHO and MUHO subjects (median (interquartile range): 1639 (1055-2396) vs. 1622 (1009-23345) ng/mL). However, in the total population insulin (r = 0.131, p = 0.0234) and hs-CRP (r = 0.165, p = 0.0045) levels were correlated with lactoferrin concentrations. In addition, a weak positive association between serum lactoferrin concentrations and anthropometric parameters was also detected, and predominantly referred to MHO group (body weight: r = 0.231, p = 0.0201; BMI: r = 0.286, p = 0.0037; waist circumference: r = 0.258, p = 0.0092). In addition, serum lactoferrin concentrations were negatively correlated with fasting glucose (r = -0.250, p = 0.0115) and HDL-C levels (r = -0.203, p = 0.0411) in MHO subjects.
+
+ CONCLUSIONS: Lactoferrin levels did not differ between MHO and MUHO women. However, some mild correlations between lactoferrin concentrations and anthropometric and metabolic parameters were observed mostly in MHO subjects.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (LTF protein, human). EC 3-4-21 (Lactoferrin).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11091976
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Jamka&issn=2072-6643&title=Nutrients&atitle=No+Difference+in+Lactoferrin+Levels+between+Metabolically+Healthy+and+Unhealthy+Obese+Women.&volume=11&issue=9&spage=&epage=&date=2019&doi=10.3390%2Fnu11091976&pmid=31443387&sid=OVID:medline
+
+<2057>
+Unique Identifier
+ 31440251
+Title
+ Perturbation of the Monocyte Compartment in Human Obesity.
+Source
+ Frontiers in Immunology. 10:1874, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Friedrich K; Sommer M; Strobel S; Thrum S; Bluher M; Wagner U; Rossol M
+Authors Full Name
+ Friedrich, Kathleen; Sommer, Miriam; Strobel, Sarah; Thrum, Stephan; Bluher, Matthias; Wagner, Ulf; Rossol, Manuela.
+Institution
+ Friedrich, Kathleen. Rheumatology Unit, Department of Medicine, University of Leipzig, Leipzig, Germany.
+ Sommer, Miriam. Rheumatology Unit, Department of Medicine, University of Leipzig, Leipzig, Germany.
+ Strobel, Sarah. Rheumatology Unit, Department of Medicine, University of Leipzig, Leipzig, Germany.
+ Thrum, Stephan. Rheumatology Unit, Department of Medicine, University of Leipzig, Leipzig, Germany.
+ Bluher, Matthias. Division of Endocrinology, Department of Medicine, University of Leipzig, Leipzig, Germany.
+ Wagner, Ulf. Rheumatology Unit, Department of Medicine, University of Leipzig, Leipzig, Germany.
+ Rossol, Manuela. Rheumatology Unit, Department of Medicine, University of Leipzig, Leipzig, Germany.
+MeSH Subject Headings
+ Adult
+ Biomarkers/me [Metabolism]
+ Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Humans
+ Inflammation/me [Metabolism]
+ Leukocytes, Mononuclear/me [Metabolism]
+ Male
+ Middle Aged
+ *Monocytes/me [Metabolism]
+ Myeloid-Derived Suppressor Cells/me [Metabolism]
+ *Obesity/me [Metabolism]
+Keyword Heading
+ CD16
+ CD56
+ macrophages
+ monocytes
+ myeloid suppressor cells (MDSC)
+ obesity
+ subpopulation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Circulating monocytes can be divided into classical (CM), intermediate (IM), and non-classical monocytes (NCM), and the classical monocytes also contain CD56+ monocytes and monocytic myeloid-derived suppressor cells (M-MDSC). The aim of the study was to evaluate the occurrence of the monocyte subpopulations in human obesity. Twenty-seven normal, 23 overweight, and 60 obese individuals (including 17 obese individuals with normal glucose tolerance and 27 with type 2 diabetes) were included into this study. Peripheral blood mononuclear cells were isolated from human blood, and surface markers to identify monocyte subpopulations were analyzed by flow cytometry. Obese individuals had higher numbers of total monocytes, CM, IM, CD56+ monocytes, and M-MDSCs. The number of CM, IM, CD56+ monocytes, and M-MDSCs, correlated positively with body mass index, body fat, waist circumference, triglycerides, C-reactive protein, and HbA1c, and negatively with high-density lipoprotein cholesterol. Individuals with obesity and type 2 diabetes had higher numbers of IM, NCM, and M-MDSCs, whereas those with obesity and impaired glucose tolerance had higher numbers of CD56+ monocytes. In summary, the comprehensive analysis of blood monocytes in human obesity revealed a shift of the monocyte compartment toward pro-inflammatory monocytes which might contribute to the development of low-grade inflammation in obesity, and immune-suppressive monocytes which might contribute to the development of cancer in obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3389%2ffimmu.2019.01874
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Friedrich&issn=1664-3224&title=Frontiers+in+Immunology&atitle=Perturbation+of+the+Monocyte+Compartment+in+Human+Obesity.&volume=10&issue=&spage=1874&epage=&date=2019&doi=10.3389%2Ffimmu.2019.01874&pmid=31440251&sid=OVID:medline
+
+<2058>
+Unique Identifier
+ 31434495
+Title
+ Endothelial-to-Mesenchymal Transition in Human Adipose Tissue Vasculature Alters the Particulate Secretome and Induces Endothelial Dysfunction.
+Source
+ Arteriosclerosis, Thrombosis & Vascular Biology. 39(10):2168-2191, 2019 10.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Haynes BA; Yang LF; Huyck RW; Lehrer EJ; Turner JM; Barabutis N; Correll VL; Mathiesen A; McPheat W; Semmes OJ; Dobrian AD
+Authors Full Name
+ Haynes, Bronson A; Yang, Li Fang; Huyck, Ryan W; Lehrer, Eric J; Turner, Joshua M; Barabutis, Nektarios; Correll, Vanessa L; Mathiesen, Allison; McPheat, William; Semmes, O John; Dobrian, Anca D.
+Institution
+ Haynes, Bronson A. the Department of Physiological Sciences (B.A.H., R.W.H., E.J.L., J.M.T., A.M., W.M., A.D.D.), Eastern Virginia Medical School, Norfolk.
+ Yang, Li Fang. Department of Microbiology and Cell and Molecular Biology and Leroy T. Canoles Cancer Center (L.F.Y., V.L.C., O.J.S.), Eastern Virginia Medical School, Norfolk.
+ Huyck, Ryan W. the Department of Physiological Sciences (B.A.H., R.W.H., E.J.L., J.M.T., A.M., W.M., A.D.D.), Eastern Virginia Medical School, Norfolk.
+ Lehrer, Eric J. the Department of Physiological Sciences (B.A.H., R.W.H., E.J.L., J.M.T., A.M., W.M., A.D.D.), Eastern Virginia Medical School, Norfolk.
+ Turner, Joshua M. the Department of Physiological Sciences (B.A.H., R.W.H., E.J.L., J.M.T., A.M., W.M., A.D.D.), Eastern Virginia Medical School, Norfolk.
+ Barabutis, Nektarios. Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe (N.B.).
+ Correll, Vanessa L. Department of Microbiology and Cell and Molecular Biology and Leroy T. Canoles Cancer Center (L.F.Y., V.L.C., O.J.S.), Eastern Virginia Medical School, Norfolk.
+ Mathiesen, Allison. the Department of Physiological Sciences (B.A.H., R.W.H., E.J.L., J.M.T., A.M., W.M., A.D.D.), Eastern Virginia Medical School, Norfolk.
+ McPheat, William. the Department of Physiological Sciences (B.A.H., R.W.H., E.J.L., J.M.T., A.M., W.M., A.D.D.), Eastern Virginia Medical School, Norfolk.
+ Semmes, O John. Department of Microbiology and Cell and Molecular Biology and Leroy T. Canoles Cancer Center (L.F.Y., V.L.C., O.J.S.), Eastern Virginia Medical School, Norfolk.
+ Dobrian, Anca D. the Department of Physiological Sciences (B.A.H., R.W.H., E.J.L., J.M.T., A.M., W.M., A.D.D.), Eastern Virginia Medical School, Norfolk.
+MeSH Subject Headings
+ *Adipose Tissue/bs [Blood Supply]
+ Adipose Tissue/me [Metabolism]
+ Analysis of Variance
+ Biomarkers/me [Metabolism]
+ Case-Control Studies
+ Cell Movement/ge [Genetics]
+ Cell Proliferation/ge [Genetics]
+ Cells, Cultured
+ Endothelial Cells/me [Metabolism]
+ Epithelial-Mesenchymal Transition/de [Drug Effects]
+ *Epithelial-Mesenchymal Transition/ge [Genetics]
+ Flow Cytometry/mt [Methods]
+ Humans
+ *Neovascularization, Pathologic/ge [Genetics]
+ *Obesity/ge [Genetics]
+ Obesity/pp [Physiopathology]
+ Proteomics/mt [Methods]
+ *Transforming Growth Factor beta1/pd [Pharmacology]
+Keyword Heading
+ angiogenesis
+ cytokine
+ extracellular vesicles
+ fatty acids
+ proteomics
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Endothelial cells (EC) in obese adipose tissue (AT) are exposed to a chronic proinflammatory environment that may induce a mesenchymal-like phenotype and altered function. The objective of this study was to establish whether endothelial-to-mesenchymal transition (EndoMT) is present in human AT in obesity and to investigate the effect of such transition on endothelial function and the endothelial particulate secretome represented by extracellular vesicles (EV). Approach and Results: We identified EndoMT in obese human AT depots by immunohistochemical co-localization of CD31 or vWF and alpha-SMA (alpha-smooth muscle actin). We showed that AT EC exposed in vitro to TGF-beta (tumor growth factor-beta), TNF-alpha (tumor necrosis factor-alpha), and IFN-gamma (interferon-gamma) undergo EndoMT with progressive loss of endothelial markers. The phenotypic change results in failure to maintain a tight barrier in culture, increased migration, and reduced angiogenesis. EndoMT also reduced mitochondrial oxidative phosphorylation and glycolytic capacity of EC. EVs produced by EC that underwent EndoMT dramatically reduced angiogenic capacity of the recipient naive ECs without affecting their migration or proliferation. Proteomic analysis of EV produced by EC in the proinflammatory conditions showed presence of several pro-inflammatory and immune proteins along with an enrichment in angiogenic receptors.
+
+ CONCLUSIONS: We demonstrated the presence of EndoMT in human AT in obesity. EndoMT in vitro resulted in production of EV that transferred some of the functional and metabolic features to recipient naive EC. This result suggests that functional and molecular features of EC that underwent EndoMT in vivo can be disseminated in a paracrine or endocrine fashion and may induce endothelial dysfunction in distant vascular beds.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Transforming Growth Factor beta1).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1161%2fATVBAHA.119.312826
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Haynes&issn=1079-5642&title=Arteriosclerosis%2C+Thrombosis+%26+Vascular+Biology&atitle=Endothelial-to-Mesenchymal+Transition+in+Human+Adipose+Tissue+Vasculature+Alters+the+Particulate+Secretome+and+Induces+Endothelial+Dysfunction.&volume=39&issue=10&spage=2168&epage=2191&date=2019&doi=10.1161%2FATVBAHA.119.312826&pmid=31434495&sid=OVID:medline
+
+<2059>
+Unique Identifier
+ 31433007
+Title
+ Sarcopenia and sarcopenic obesity as prognostic predictors in hospitalized elderly patients with acute myocardial infarction.
+Source
+ Einstein. 17(4):eAO4632, 2019 Aug 19.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Santana NM; Mendes RML; Silva NFD; Pinho CPS
+Author NameID
+ Santana, Natalia de Moraes; ORCID: http://orcid.org/0000-0002-9574-2239
+ Mendes, Roberta Maria Lins; ORCID: http://orcid.org/0000-0002-9750-2992
+ Silva, Nadja Fernandes da; ORCID: http://orcid.org/0000-0002-3664-6132
+ Pinho, Claudia Porto Sabino; ORCID: http://orcid.org/0000-0002-5689-5048
+Authors Full Name
+ Santana, Natalia de Moraes; Mendes, Roberta Maria Lins; Silva, Nadja Fernandes da; Pinho, Claudia Porto Sabino.
+Institution
+ Santana, Natalia de Moraes. Universidade de Pernambuco, Recife, PE, Brazil.
+ Mendes, Roberta Maria Lins. Universidade de Pernambuco, Recife, PE, Brazil.
+ Silva, Nadja Fernandes da. Universidade de Pernambuco, Recife, PE, Brazil.
+ Pinho, Claudia Porto Sabino. Universidade de Pernambuco, Recife, PE, Brazil.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ Biomarkers/bl [Blood]
+ Cross-Sectional Studies
+ Female
+ Geriatric Assessment
+ Humans
+ Male
+ Middle Aged
+ *Motor Activity/ph [Physiology]
+ *Muscle Strength/ph [Physiology]
+ *Myocardial Infarction/et [Etiology]
+ Myocardial Infarction/pp [Physiopathology]
+ *Obesity/co [Complications]
+ Obesity/pp [Physiopathology]
+ Predictive Value of Tests
+ Prognosis
+ Risk Factors
+ *Sarcopenia/co [Complications]
+ Sarcopenia/pp [Physiopathology]
+Abstract
+ OBJECTIVE: To investigate the potential value of sarcopenia and sarcopenic obesity as prognostic predictors in hospitalized elderly patients with acute myocardial infarction.
+
+ METHODS: A cross-sectional study based on data collected from elderly patients with acute myocardial infarction, admitted to a public hospital located in the Northeastern region of Brazil, from April to July 2015. The diagnosis of sarcopenia was based on muscle mass, muscle strength and physical performance measurements. Cardiovascular risk and prognostic markers, such as troponin and creatine kynase MB isoenzyme values, acute myocardial infarction classification according to ST segment elevation, and thrombolysis in myocardial infarction score were used.
+
+ RESULTS: The sample comprised 99 patients with mean age of 71.6 (+/-7.4) years. Prevalence of sarcopenia and sarcopenic obesity was 64.6% and 35.4%, respectively. Sarcopenia was more prevalent among males (p=0.017) aged >80 years (p=0.008). Thrombolysis in myocardial infarction was the only marker of cardiovascular risk significantly associated with sarcopenia (p=0.002).
+
+ CONCLUSION: Prevalence of sarcopenia was high and associated with thrombolysis in myocardial infarction risk score. Sarcopenic obesity affected approximately one-third of patients and was not associated with any of the prognostic predictors.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.31744%2feinstein_journal%2f2019AO4632
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Santana&issn=1679-4508&title=Einstein&atitle=Sarcopenia+and+sarcopenic+obesity+as+prognostic+predictors+in+hospitalized+elderly+patients+with+acute+myocardial+infarction.&volume=17&issue=4&spage=eAO4632&epage=&date=2019&doi=10.31744%2Feinstein_journal%2F2019AO4632&pmid=31433007&sid=OVID:medline
+
+<2060>
+Unique Identifier
+ 31425964
+Title
+ Comparison of prevalence of life style risk factors and 10 year risk of CVD event among rural and tribal population of Kollegal Taluk, Chamrajanagar district, South India.
+Source
+ Diabetes & Metabolic Syndrome. 13(5):2961-2966, 2019 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Madhu B; Prathyusha K; Prakruthi P; Srinath KM
+Authors Full Name
+ Madhu, B; Prathyusha, K; Prakruthi, P; Srinath, K M.
+Institution
+ Madhu, B. Department of Community Medicine, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. Electronic address: madhub@jssuni.edu.in.
+ Prathyusha, K. Department of Community Medicine, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
+ Prakruthi, P. Department of Community Medicine, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
+ Srinath, K M. Department of General Medicine, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Blood Pressure
+ Cardiovascular Diseases/ep [Epidemiology]
+ *Cardiovascular Diseases/et [Etiology]
+ Cross-Sectional Studies
+ *Diabetes Mellitus/pp [Physiopathology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Hypertension/co [Complications]
+ India/ep [Epidemiology]
+ *Life Style
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ Prevalence
+ Prognosis
+ Risk Factors
+ *Rural Population/sn [Statistics & Numerical Data]
+Keyword Heading
+ Cardiovascular risk factors
+ Rural
+ Ten year risk of stroke and MI
+ Tribal
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ CONTEXT: Cardiovascular diseases have been recognized as leading cause of death. Three-fourths of CVD deaths occur in low and middle income countries. Surveillance of CVD risk factors is a key strategy for effective CVD prevention.
+
+ AIMS: To identify the extent of CVD risk factors and 10 year risk of developing Cardiovascular Disease events among rural and tribal population.
+
+ SUBJECTS AND METHODS: This community based cross sectional study was conducted on a total of 482 rural and 415 tribal subjects aged above 30 years from Kollegal taluk, Chamrajanagar, Karnataka, India. Tobacco and alcohol consumption, BMI, blood pressure and capillary blood glucose were estimated. WHO/ISH risk prediction chart was used to predict 10 year risk of MI/stroke.
+
+ RESULTS: Tobacco consumption was 15.4% (rural) and 90.8% (tribal). Alcohol consumption was 10.8% (rural) and 21.9% (tribal), Obesity was 40.2% (rural) and 14.0% (tribal). Prevalence of Hypertension was 49.8% (rural) and 32.2% (Tribal) and diabetes 8.3% (rural) and 2.9% (tribal). Nearly one fourth of the population are at moderate risk (10-30%) and one tenth are at high risk (30%) of MI/Stroke within 10 years.
+
+ CONCLUSIONS: High prevalence of tobacco consumption among tribal and high prevalence of hypertension and diabetes among rural predisposes 10% of population to moderate to high risk of stroke/MI within 10 years. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Comparative Study. Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.07.056
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Madhu&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Comparison+of+prevalence+of+life+style+risk+factors+and+10+year+risk+of+CVD+event+among+rural+and+tribal+population+of+Kollegal+Taluk%2C+Chamrajanagar+district%2C+South+India.&volume=13&issue=5&spage=2961&epage=2966&date=2019&doi=10.1016%2Fj.dsx.2019.07.056&pmid=31425964&sid=OVID:medline
+
+<2061>
+Unique Identifier
+ 31425941
+Title
+ Does vitamin D status correlate with insulin resistance in obese prediabetic patients? An Egyptian multicenter study.
+Source
+ Diabetes & Metabolic Syndrome. 13(5):2813-2817, 2019 Sep - Oct.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hetta HF; Fahmy EM; Mohamed GA; Gaber MA; Elkady A; Elbadr MM; Al-Kadmy IMS
+Authors Full Name
+ Hetta, Helal F; Fahmy, Eman M; Mohamed, Ghada A; Gaber, Marwa A; Elkady, Azza; Elbadr, Mohamed M; Al-Kadmy, Israa M S.
+Institution
+ Hetta, Helal F. Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt. Electronic address: helal.hetta@uc.ed.
+ Fahmy, Eman M. Department of Endocrinology, Faculty of Medicine, Helwan University, Egypt.
+ Mohamed, Ghada A. Department of Internal Medicine, Faculty of Medicine, Assiut University, Egypt.
+ Gaber, Marwa A. Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
+ Elkady, Azza. Sohag General Hospital, Sohag, Egypt.
+ Elbadr, Mohamed M. Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.
+ Al-Kadmy, Israa M S. Faculty of Science and Engineering, School of Engineering, University of Plymouth, Plymouth, PL4 8AA, UK; Branch of Biotechnology, Department of Biology, College of Science, Mustansiriyah University, POX, 10244, Baghdad, Iraq. Electronic address: israaalkadmy@gmail.com.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ Blood Glucose/an [Analysis]
+ Case-Control Studies
+ Cross-Sectional Studies
+ Egypt/ep [Epidemiology]
+ Female
+ Follow-Up Studies
+ Glycated Hemoglobin/an [Analysis]
+ Humans
+ Incidence
+ *Insulin Resistance
+ Male
+ *Obesity/pp [Physiopathology]
+ *Prediabetic State/pp [Physiopathology]
+ Prognosis
+ *Vitamin D/bl [Blood]
+ Vitamin D Deficiency/bl [Blood]
+ *Vitamin D Deficiency/ep [Epidemiology]
+ Vitamins/bl [Blood]
+Keyword Heading
+ Insulin resistance
+ Obesity
+ Prediabetes
+ Vitamin D
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: The link between Vitamin-D deficiency and type 2 diabetes (T2D) is well-established. Since prediabetic obese populations have the greatest risk to develop to T2D, it was important in our study to examine serum 25(OH) D3 concentration among prediabetic obese patients and to evaluate the correlation between serum level of vitamin D and BMI, FBS, HOMA IR and HbA1c among prediabetes patients.
+
+ METHODS: A multicenter case control study was carried out among 101 prediabetic persons & 50 controls, after obtaining consent from subjects and clearance from institutional ethics committee. Serum vitamin D level, Plasma levels of glycosylated hemoglobin (HbA1c) and fasting insulin levels were measured by ELISA in both groups enrolled in the study.
+
+ RESULTS: The prevalence of vitamin-D deficiency/insufficiency was (73.3%) (n=74) among 101 prediabetic obese individuals. Also, A significant inverse correlation was observed between vitamin D levels & body mass index(r=- 0.28, P=0.004); fasting blood sugar (r=- 0.22, P=0.002); HOMA insulin resistance (r=- 0.25P=0.01); HbA1C (r=- 0.2, P= 0.004).
+
+ CONCLUSIONS: High prevalence of vitamin D deficiency exists among obese prediabetic individuals and there is significant inverse correlation between BMI, FBS, HOMA IR, HbA1c and vitamin D level. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Vitamins). 0 (hemoglobin A1c protein, human). 1406-16-2 (Vitamin D).
+Publication Type
+ Journal Article. Multicenter Study.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.07.043
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hetta&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Does+vitamin+D+status+correlate+with+insulin+resistance+in+obese+prediabetic+patients%3F+An+Egyptian+multicenter+study.&volume=13&issue=5&spage=2813&epage=2817&date=2019&doi=10.1016%2Fj.dsx.2019.07.043&pmid=31425941&sid=OVID:medline
+
+<2062>
+Unique Identifier
+ 31413841
+Title
+ Frequency of self-monitoring of blood glucose in relation to weight loss and A1C during intensive multidisciplinary weight management in patients with type 2 diabetes and obesity.
+Source
+ BMJ Open Diabetes Research & Care. 7(1):e000659, 2019.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tomah S; Mahmoud N; Mottalib A; Pober DM; Tasabehji MW; Ashrafzadeh S; Hamdy O
+Author NameID
+ Tomah, Shaheen; ORCID: https://orcid.org/0000-0003-3864-7494
+ Mottalib, Adham; ORCID: https://orcid.org/0000-0002-8573-6329
+Authors Full Name
+ Tomah, Shaheen; Mahmoud, Noor; Mottalib, Adham; Pober, David M; Tasabehji, Mhd Wael; Ashrafzadeh, Sahar; Hamdy, Osama.
+Institution
+ Tomah, Shaheen. Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
+ Mahmoud, Noor. Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
+ Mottalib, Adham. Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
+ Mottalib, Adham. Department of Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
+ Pober, David M. Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
+ Tasabehji, Mhd Wael. Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
+ Ashrafzadeh, Sahar. Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
+ Hamdy, Osama. Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ *Blood Glucose/an [Analysis]
+ *Blood Glucose Self-Monitoring/sn [Statistics & Numerical Data]
+ Body Weight
+ Boston/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/ep [Epidemiology]
+ Diabetes Mellitus, Type 2/th [Therapy]
+ Exercise Therapy
+ Female
+ Follow-Up Studies
+ *Glycated Hemoglobin/an [Analysis]
+ Humans
+ *Hypoglycemic Agents/tu [Therapeutic Use]
+ Male
+ Middle Aged
+ Nutrition Therapy
+ Obesity/pp [Physiopathology]
+ *Patient Compliance/sn [Statistics & Numerical Data]
+ Prognosis
+ Retrospective Studies
+ *Weight Loss
+Keyword Heading
+ lifestyle intervention
+ obesity
+ self-monitoring of blood glucose
+ type 2 diabetes
+ weight management
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Objective: We evaluated the relationship between frequency of self-monitoring of blood glucose (SMBG) and body weight, A1C, and cardiovascular risk factors in patients with type 2 diabetes (T2D) and obesity enrolled in a 12-week intensive multidisciplinary weight management (IMWM) program.
+
+ Research design and methods: We conducted a retrospective analysis of 42 patients who electronically uploaded their SMBG data over 12 weeks of an IMWM program and divided them into tertiles based on their average frequency of SMBG per day. Mean (range) SMBG frequencies were 2.3 (1.1-2.9) times/day, 3.4 (3-3.9) times/day, and 5 (4-7.7) times/day in the lowest, middle, and highest tertiles, respectively. Anthropometric and metabolic parameters were measured at baseline and after 12 weeks of intervention.
+
+ Results: Participants in the highest tertile achieved a median change (IQR) in body weight of -10.4 kg (-7.6 to -14.4 kg) compared with -8.3 kg (-5.2 to -12.2 kg), and -6.9 kg (-4.2 to -8.9 kg) in the middle and lowest tertiles, respectively (p=0.018 for trend). Participants in the highest tertile had a median change (IQR) in A1C of -1.25% (-0.6 to -3.1%) compared with -0.8% (-0.3% to -2%) and -0.5% (-0.2% to -1.2%) in the middle and lowest tertiles, respectively (p=0.048 for trend). The association between change in body weight and SMBG frequency remained significant after adjusting for age, sex, baseline body mass index, diabetes duration, and use of insulin therapy.
+
+ Conclusions: Increased frequency of SMBG during IMWM is associated with significantly better weight loss and improvement of A1C in patients with T2D and obesity. These findings may suggest future clinical recommendations aimed at increasing SMBG frequency to achieve the most favorable outcomes.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (Glycated Hemoglobin A). 0 (Hypoglycemic Agents). 0 (hemoglobin A1c protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1136%2fbmjdrc-2019-000659
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tomah&issn=2052-4897&title=BMJ+Open+Diabetes+Research+%26+Care&atitle=Frequency+of+self-monitoring+of+blood+glucose+in+relation+to+weight+loss+and+A1C+during+intensive+multidisciplinary+weight+management+in+patients+with+type+2+diabetes+and+obesity.&volume=7&issue=1&spage=e000659&epage=&date=2019&doi=10.1136%2Fbmjdrc-2019-000659&pmid=31413841&sid=OVID:medline
+
+<2063>
+Unique Identifier
+ 31413305
+Title
+ Reduced miR-181d level in obesity and its role in lipid metabolism via regulation of ANGPTL3.
+Source
+ Scientific Reports. 9(1):11866, 2019 08 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Abu-Farha M; Cherian P; Al-Khairi I; Nizam R; Alkandari A; Arefanian H; Tuomilehto J; Al-Mulla F; Abubaker J
+Author NameID
+ Abu-Farha, Mohamed; ORCID: http://orcid.org/0000-0001-8357-1252
+ Arefanian, Hossein; ORCID: http://orcid.org/0000-0001-6414-0916
+Authors Full Name
+ Abu-Farha, Mohamed; Cherian, Preethi; Al-Khairi, Irina; Nizam, Rasheeba; Alkandari, Abdullah; Arefanian, Hossein; Tuomilehto, Jaakko; Al-Mulla, Fahd; Abubaker, Jehad.
+Institution
+ Abu-Farha, Mohamed. Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Al Kuwayt, Kuwait.
+ Cherian, Preethi. Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Al Kuwayt, Kuwait.
+ Al-Khairi, Irina. Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Al Kuwayt, Kuwait.
+ Nizam, Rasheeba. Functional Genomic Unit, Dasman Diabetes Institute, Al Kuwayt, Kuwait.
+ Alkandari, Abdullah. Clinical Trial Units, Dasman Diabetes Institute, Al Kuwayt, Kuwait.
+ Arefanian, Hossein. Immunology Unit, Dasman Diabetes Institute, Al Kuwayt, Kuwait.
+ Tuomilehto, Jaakko. Research Division, Dasman Diabetes Institute, Al Kuwayt, Kuwait.
+ Al-Mulla, Fahd. Functional Genomic Unit, Dasman Diabetes Institute, Al Kuwayt, Kuwait. fahd.almulla@dasmaninstitute.org.
+ Abubaker, Jehad. Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Al Kuwayt, Kuwait. jehad.abubakr@dasmaninstitute.org.
+MeSH Subject Headings
+ 3' Untranslated Regions/ge [Genetics]
+ Adipose Tissue/me [Metabolism]
+ Adult
+ Angiopoietin-Like Protein 3
+ Angiopoietin-like Proteins/ge [Genetics]
+ *Angiopoietin-like Proteins/me [Metabolism]
+ Base Sequence
+ Biomarkers/me [Metabolism]
+ Gene Expression Regulation
+ Hep G2 Cells
+ Humans
+ Inflammation/ge [Genetics]
+ *Lipid Metabolism/ge [Genetics]
+ Lipoprotein Lipase/me [Metabolism]
+ MicroRNAs/bl [Blood]
+ MicroRNAs/ge [Genetics]
+ *MicroRNAs/me [Metabolism]
+ Middle Aged
+ Obesity/bl [Blood]
+ *Obesity/ge [Genetics]
+ RNA, Messenger/ge [Genetics]
+ RNA, Messenger/me [Metabolism]
+ Reproducibility of Results
+Abstract
+ Obesity impacts the endocrine and metabolic functions of the adipose tissue. There is increasing interest in the role of epigenetic factors in obesity and its impact on diabetes and dyslipidemia. One such substance, miR-181, reduces plasma triglyceride levels in mice by targeting isocitrate dehydrogenase 1. In the other hand, the adipocyte differentiation and lipid regulating hormone angiopoietin-like 3 (ANGPTL3) is a known regulator of circulating apolipoproteins through its inhibition of the lipoprotein lipase activity. We aimed to study the miR-181d expression in the blood and adipose tissue in a cohort of obese and non-obese people, assessing its possible role in obesity. We also aimed to confirm whether miR-181d can bind and regulate ANGPTL3. miR-181d expression levels were investigated in 144 participants, 82 who were non-obese (body mass index [BMI] < 30) and 62 who were obese (BMI > 30). miR-181d levels in plasma and adipose tissue were measured by RT-PCR. Hepatocyte cell cultures were assessed by overexpression and 3'-UTR-luciferase assays for miR-181d binding to its target protein and its effect on the protein. The plasma levels of ANGPTL3 were also measured by ELISA. The miR-181d levels were significantly lower in obese than in non-obese individuals. In vitro analysis confirmed miR-181 binding to and repression of the ANGPTL3 transcript. Obesity leads to alterations in miR-181d expression. Its downregulation in obese humans was inversely correlated with ANGPTL3, a protein involved in adipocyte differentiation and lipid metabolism. miR-181d can be used as an inhibitor of ANGPTL3 to reduce the TG plasma level.
+Registry Number/Name of Substance
+ 0 (3' Untranslated Regions). 0 (ANGPTL3 protein, human). 0 (Angiopoietin-Like Protein 3). 0 (Angiopoietin-like Proteins). 0 (Biomarkers). 0 (MIrn181 microRNA, human). 0 (MicroRNAs). 0 (RNA, Messenger). EC 3-1-1-34 (Lipoprotein Lipase).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1038%2fs41598-019-48371-2
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Abu-Farha&issn=2045-2322&title=Scientific+Reports&atitle=Reduced+miR-181d+level+in+obesity+and+its+role+in+lipid+metabolism+via+regulation+of+ANGPTL3.&volume=9&issue=1&spage=11866&epage=&date=2019&doi=10.1038%2Fs41598-019-48371-2&pmid=31413305&sid=OVID:medline
+
+<2064>
+Unique Identifier
+ 31408896
+Title
+ The Effect of Zinc Supplementation on Serum Leptin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
+Source
+ Hormone & Metabolic Research. 51(8):503-510, 2019 Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Khorshidi M; Zarezadeh M; Sadeghi A; Teymouri A; Emami MR; Kord-Varkaneh H; Aryaeian N; Rahmani J; Mousavi SM
+Authors Full Name
+ Khorshidi, Masoud; Zarezadeh, Meysam; Sadeghi, Alireza; Teymouri, Alireza; Emami, Mohammad Reza; Kord-Varkaneh, Hamed; Aryaeian, Naheed; Rahmani, Jamal; Mousavi, Seyed Mohammad.
+Institution
+ Khorshidi, Masoud. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
+ Zarezadeh, Meysam. Department of Cellular and Molecular Nutrition, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Sadeghi, Alireza. Department of Cellular and Molecular Nutrition, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Teymouri, Alireza. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
+ Emami, Mohammad Reza. Department of Nutrition, Kermanshah University of Medical Sciences, Kermanshah, Iran.
+ Kord-Varkaneh, Hamed. Student Research Committee, Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Aryaeian, Naheed. Nutrition Department, Iran University of Medical Sciences, Tehran, Iran.
+ Rahmani, Jamal. Department of Community Nutrition, Shahid Behehshti University of Medical Sciences, Tehran, Iran.
+ Mousavi, Seyed Mohammad. Department of Community Nutrition, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Mousavi, Seyed Mohammad. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+MeSH Subject Headings
+ *Biomarkers/bl [Blood]
+ *Dietary Supplements
+ Humans
+ *Leptin/bl [Blood]
+ *Obesity/bl [Blood]
+ Obesity/pc [Prevention & Control]
+ Prognosis
+ Randomized Controlled Trials as Topic
+ *Zinc/ad [Administration & Dosage]
+Abstract
+ Recently, obesity has become a common worldwide concern. Leptin, as an adipocytokine, plays a major role in the etiology of obesity. Prior studies have demonstrated that zinc potentially affects serum leptin levels. However, clinical trials carried out in this regard are not consistent. Therefore, current meta-analysis was conducted to ascertain the actual effect of zinc supplementation on serum leptin levels in adults. Databases of PubMed, SCOPUS, and Google Scholar were methodically searched to identify relevant articles up to April 2018. Clinical trials that examined the effect of zinc supplementation on serum leptin concentrations as outcome variables in human adults were included. The mean difference (SD) of leptin changes in the intervention and placebo groups were used to calculate the overall effect size. Totally, 663 articles were identified, of which 6 studies were eligible randomized controlled trials (RCTs) with 7 treatment arms. The analysis suggested that zinc supplementation exerts no significant effect on overall serum leptin (WMD: 0.74 ng/ml; 95% CI: -1.39 to 2.87, p=0.49). Nevertheless, sex and duration of intervention seemed to impact the extent of zinc's influence. In trials with female subjects, zinc consumption led to a significant decrease in serum leptin level (WMD: -1.93 ng/ml; 95% CI: -3.72 to -0.14, p=0.03) as well as trials that lasted for more than 6 weeks (WMD: -1.71 ng/ml; 95% CI: -3.07 to -0.35, p=0.01), in comparison to the control group. Zinc supplementation did not significantly improve leptin concentrations, but it may result in a decreased circulating leptin level in studies with a duration of more than 6 weeks especially among females. Copyright © Georg Thieme Verlag KG Stuttgart . New York.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Leptin). J41CSQ7QDS (Zinc).
+Publication Type
+ Journal Article. Meta-Analysis. Systematic Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1055%2fa-0955-6662
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Khorshidi&issn=0018-5043&title=Hormone+%26+Metabolic+Research&atitle=The+Effect+of+Zinc+Supplementation+on+Serum+Leptin+Levels%3A+A+Systematic+Review+and+Meta-Analysis+of+Randomized+Controlled+Trials.&volume=51&issue=8&spage=503&epage=510&date=2019&doi=10.1055%2Fa-0955-6662&pmid=31408896&sid=OVID:medline
+
+<2065>
+Unique Identifier
+ 31408377
+Title
+ Calcification biomarkers and vascular dysfunction in obesity and type 2 diabetes: influence of oral hypoglycemic agents.
+Source
+ American Journal of Physiology - Endocrinology & Metabolism. 317(4):E658-E666, 2019 10 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Schinzari F; Tesauro M; Bertoli A; Valentini A; Veneziani A; Campia U; Cardillo C
+Author NameID
+ Cardillo, Carmine; ORCID: https://orcid.org/0000-0001-5182-3005
+Authors Full Name
+ Schinzari, Francesca; Tesauro, Manfredi; Bertoli, Aldo; Valentini, Alessia; Veneziani, Augusto; Campia, Umberto; Cardillo, Carmine.
+Institution
+ Schinzari, Francesca. Internal Medicine, Policlinico A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
+ Tesauro, Manfredi. Department of Systems Medicine, Tor Vergata University, Rome, Italy.
+ Bertoli, Aldo. Department of Systems Medicine, Tor Vergata University, Rome, Italy.
+ Valentini, Alessia. Department of Systems Medicine, Tor Vergata University, Rome, Italy.
+ Veneziani, Augusto. Department of Surgery, Catholic University, Rome, Italy.
+ Campia, Umberto. Department of Vascular Medicine, Brigham and Women Hospital, Harvard Medical School, Boston, Massachusetts.
+ Cardillo, Carmine. Internal Medicine, Policlinico A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
+ Cardillo, Carmine. Department of Internal Medicine, Catholic University, Rome, Italy.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/bl [Blood]
+ Blood Glucose/me [Metabolism]
+ Calcinosis/et [Etiology]
+ *Calcinosis/me [Metabolism]
+ Chemokine CCL5/bl [Blood]
+ *Diabetes Mellitus, Type 2/co [Complications]
+ *Diabetes Mellitus, Type 2/me [Metabolism]
+ Female
+ Humans
+ *Hypoglycemic Agents/pd [Pharmacology]
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ *Obesity/me [Metabolism]
+ Obesity, Metabolically Benign
+ Osteopontin/bl [Blood]
+ Osteoprotegerin/bl [Blood]
+ *Vascular Diseases/et [Etiology]
+ *Vascular Diseases/me [Metabolism]
+ Vasodilation
+ alpha-2-HS-Glycoprotein/an [Analysis]
+Keyword Heading
+ diabetes
+ obesity
+ osteopontin
+ osteoprotegerin
+ vasodilation
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Vascular aging in obesity and type 2 diabetes (T2D) is associated with progressive vascular calcification, an independent predictor of morbidity and mortality. Pathways for vascular calcification modulate bone matrix deposition, thus regulating calcium deposits. We investigated the association between biomarkers of vascular calcification and vasodilator function in obesity or T2D, and whether antidiabetic therapies favorably impact those markers. Circulating levels of proteins involved in vascular calcification, such as osteopontin (OPN), osteoprotegerin (OPG), regulated on activation, normal T cell expressed and secreted (RANTES), and fetuin-A were measured in lean subjects, individuals with metabolically healthy obesity (MHO), and patients with metabolically unhealthy obesity (MUO) or T2D. Vasodilator function was assessed by infusion of ACh and sodium nitroprusside (SNP). Circulating levels of OPN were higher in the MUO/T2D group than in lean subjects (P < 0.05); OPG and RANTES were higher in MUO/T2D group than in the other groups (both P < 0.001); fetuin-A was not different between groups (P > 0.05); vasodilator responses to either ACh or SNP were impaired in both MUO/T2D and MHO compared with lean subjects (all P < 0.001). In patients with T2D who were enrolled in the intervention trial, antidiabetic treatment with glyburide, metformin, or pioglitazone resulted in a significant reduction of circulating OPG (P = 0.001), without changes in the other biomarkers and vasodilator responses (all P > 0.05). In conclusion, obese patients with MUO/T2D have elevated circulating OPN, OPG, and RANTES; in these patients, antidiabetic treatment reduces only circulating OPG. Further study is needed to better understand the mechanisms of vascular calcifications in obesity and diabetes.
+Registry Number/Name of Substance
+ 0 (AHSG protein, human). 0 (Biomarkers). 0 (Blood Glucose). 0 (CCL5 protein, human). 0 (Chemokine CCL5). 0 (Hypoglycemic Agents). 0 (Osteoprotegerin). 0 (SPP1 protein, human). 0 (TNFRSF11B protein, human). 0 (alpha-2-HS-Glycoprotein). 106441-73-0 (Osteopontin).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1152%2fajpendo.00204.2019
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Schinzari&issn=0193-1849&title=American+Journal+of+Physiology+-+Endocrinology+%26+Metabolism&atitle=Calcification+biomarkers+and+vascular+dysfunction+in+obesity+and+type+2+diabetes%3A+influence+of+oral+hypoglycemic+agents.&volume=317&issue=4&spage=E658&epage=E666&date=2019&doi=10.1152%2Fajpendo.00204.2019&pmid=31408377&sid=OVID:medline
+
+<2066>
+Unique Identifier
+ 31408149
+Title
+ Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study.
+Source
+ Journal of Clinical Endocrinology & Metabolism. 104(12):6291-6300, 2019 12 01.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Davis SR; Bell RJ; Robinson PJ; Handelsman DJ; Gilbert T; Phung J; Desai R; Lockery JE; Woods RL; Wolfe RS; Reid CM; Nelson MR; Murray AM; McNeil JJ
+Corporate Author
+ ASPREE Investigator Group
+Authors Full Name
+ Davis, Susan R; Bell, Robin J; Robinson, Penelope J; Handelsman, David J; Gilbert, Tom; Phung, James; Desai, Reena; Lockery, Jessica E; Woods, Robyn L; Wolfe, Rory S; Reid, Christopher M; Nelson, Mark R; Murray, Anne M; McNeil, John J.
+Institution
+ Davis, Susan R. Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria Australia.
+ Bell, Robin J. Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria Australia.
+ Robinson, Penelope J. Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria Australia.
+ Handelsman, David J. ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia.
+ Gilbert, Tom. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
+ Phung, James. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
+ Desai, Reena. ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia.
+ Lockery, Jessica E. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
+ Woods, Robyn L. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
+ Wolfe, Rory S. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
+ Reid, Christopher M. School of Public Health, Curtin University, Perth, Western Australia, Australia.
+ Nelson, Mark R. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
+ Nelson, Mark R. Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
+ Murray, Anne M. Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare, Minneapolis, Minnesota.
+ Murray, Anne M. Division of Geriatrics, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
+ McNeil, John J. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
+MeSH Subject Headings
+ Aged
+ Aged, 80 and over
+ *Aging
+ *Biomarkers/bl [Blood]
+ Community-Based Participatory Research
+ Cross-Sectional Studies
+ *Dehydroepiandrosterone/bl [Blood]
+ *Estrone/bl [Blood]
+ Female
+ Follow-Up Studies
+ Humans
+ *Obesity/bl [Blood]
+ Obesity/pp [Physiopathology]
+ *Overweight/bl [Blood]
+ Overweight/pp [Physiopathology]
+ Prognosis
+ *Testosterone/bl [Blood]
+Abstract
+ CONTEXT: There is a lack of understanding of what is normal in terms of sex steroid levels in older women.
+
+ OBJECTIVE: To determine whether sex steroid levels vary with age in and establish reference ranges for women >70 years of age.
+
+ DESIGN AND SETTING: Cross-sectional, community-based study.
+
+ PARTICIPANTS: Included 6392 women >=70 years of age.
+
+ MAIN OUTCOME MEASURES: Sex steroids measured by liquid chromatography-tandem mass spectrometry. A reference group, to establish sex steroid age-specific reference ranges, excluded women using systemic or topical sex steroid, antiandrogen or glucocorticoid therapy, or an antiglycemic agent.
+
+ RESULTS: The reference group of 5326 women had a mean age of 75.1 (+/-4.2) years, range of 70 to 94.7 years. Median values (range) were 181.2 pmol/L (3.7 to 5768.9) for estrone (E1), 0.38 nmol/L (0.035 to 8.56) for testosterone (T), 2.60 nmol/L (0.07 to 46.85) for dehydroepiandrosterone (DHEA), and 41.6 nmol/L (2.4 to 176.6) for SHBG. Estradiol and DHT were below method sensitivity in 66.1% and 72.7% of the samples, respectively. Compared with women aged 70 to 74 years, women aged >=85 years had higher median levels of E1 (11.7%, P = 0.01), T (11.3%, P = 0.02), and SHBG (22.7%, P < 0.001) and lower DHEA (30% less, P < 0.001). Women with overweight and obesity had higher E1 (P < 0.001) and T (P < 0.03) and lower SHBG (P < 0.001) than did women with normal body mass index. Smokers had 17.2% higher median T levels (P = 0.005).
+
+ CONCLUSION: From the age of 70 years, T and E1 increase with age, despite a steady decline in DHEA. Whether E1 and T are biomarkers for longevity or contribute to healthy aging merits investigation. Copyright © 2019 Endocrine Society.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 2DI9HA706A (Estrone). 3XMK78S47O (Testosterone). 459AG36T1B (Dehydroepiandrosterone).
+Publication Type
+ Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1210%2fjc.2019-00743
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Davis&issn=0021-972X&title=Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Testosterone+and+Estrone+Increase+From+the+Age+of+70+Years%3A+Findings+From+the+Sex+Hormones+in+Older+Women+Study.&volume=104&issue=12&spage=6291&epage=6300&date=2019&doi=10.1210%2Fjc.2019-00743&pmid=31408149&sid=OVID:medline
+
+<2067>
+Unique Identifier
+ 31405709
+Title
+ Adherence to a healthy plant diet may reduce inflammatory factors in obese and overweight women-a cross-sectional study.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2795-2802, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Bolori P; Setaysh L; Rasaei N; Jarrahi F; Yekaninejad MS; Mirzaei K
+Authors Full Name
+ Bolori, Parvin; Setaysh, Leila; Rasaei, Niloufar; Jarrahi, Farshad; Yekaninejad, Mir Saeid; Mirzaei, Khadijeh.
+Institution
+ Bolori, Parvin. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Setaysh, Leila. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Rasaei, Niloufar. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Jarrahi, Farshad. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
+ Yekaninejad, Mir Saeid. Department of epidemiology, School of public health, Tehran University of Medical Sciences, Tehran, Iran.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: mirzaei_kh@tums.ac.ir.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Cross-Sectional Studies
+ *Diet, Healthy
+ *Diet, Vegetarian
+ Feeding Behavior
+ Female
+ Follow-Up Studies
+ Humans
+ Inflammation/me [Metabolism]
+ *Inflammation/pc [Prevention & Control]
+ *Inflammation Mediators/me [Metabolism]
+ Middle Aged
+ *Obesity/dh [Diet Therapy]
+ Obesity/ep [Epidemiology]
+ *Overweight/dh [Diet Therapy]
+ Overweight/ep [Epidemiology]
+ Prognosis
+ Random Allocation
+ Young Adult
+Keyword Heading
+ Inflammation
+ Liver factors
+ Obesity and overweight
+ TGF-beta
+ Vegetarian diet
+ hs-CRP
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: Obesity and overweight which are consequence of some interaction factor such as genetics and behavioral habit. Obesity as a metabolic disorder and chronic inflammation is a trigger to countless disease. The main goal of this study is to investigate the interaction of herbal diet on the levels of liver enzymes, inflammatory factors and adipocytes profile.
+
+ MATERIALS AND METHODS: A total of 240 adult women range of 18-48 years were included in the current comparative cross-sectional study. Body composition and dietary intake (using a validated semi-quantitative food frequency questionnaire (FFQ)) were assessed in all participants. In determining a plant based diet index (PDI), vegetarian foods were taken positive score and reverse points for animal foods. For determining a healthful plant based diet index (hPDI), healthy plant foods received positive scores, while less healthy plant foods and animal foods received reverse scores. To create an unhealthful plant-based diet index (uPDI), positive scores were assigned to less healthy plant foods and reverse scores to healthy plant foods and animal foods. For the measurement of serum liver enzymes and inflammatory factors, an enzyme-linked immunosorbent assay (ELISA) method was used.
+
+ RESULTS: Healthy diet like whole grains, fruits, vegetables, cereals, and beverages such as tea and coffee, based on dietary guidelines, significantly reduced the amount of hs-CRP and TGF-beta (P<0.0001). Higher adhering to hPDI may as a result in higher intake of fiber intake, antioxidants, unsaturated fats, micronutrients, could reduce saturated fats and iron content, and finally weight loss, and reduce inflammation in the body.
+
+ CONCLUSION: Base on our finding, in those people who intake higher amounts of healthy plant foods, (vegetable types), instead of unhealthy herbal foods (sweets and desserts), might be useful to reduce inflammation factor like TGF-beta and hs-CRP. Women with a higher compliance score in uPDI group (juices, refined grains, starches sweetened with sugar, sweets, and desserts) did not have significantly increase in inflammatory factors levels. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Inflammation Mediators).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.07.019
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Bolori&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Adherence+to+a+healthy+plant+diet+may+reduce+inflammatory+factors+in+obese+and+overweight+women-a+cross-sectional+study.&volume=13&issue=4&spage=2795&epage=2802&date=2019&doi=10.1016%2Fj.dsx.2019.07.019&pmid=31405709&sid=OVID:medline
+
+<2068>
+Unique Identifier
+ 31405705
+Title
+ The association between total antioxidant capacity and resting metabolic rate (RMR) / respiratory quotient (RQ) in overweight and obese woman.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2763-2767, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aghamohammadi V; Sajjadi SF; Jarrahi F; Abdollahi A; Mirzaei K
+Authors Full Name
+ Aghamohammadi, Vajiheh; Sajjadi, Seyedeh Forough; Jarrahi, Farshad; Abdollahi, Afsoun; Mirzaei, Khadijeh.
+Institution
+ Aghamohammadi, Vajiheh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: Aghamohamadi.net@gmail.com.
+ Sajjadi, Seyedeh Forough. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: frq.sajadi@gmail.com.
+ Jarrahi, Farshad. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: jarrahifarshad@gmail.com.
+ Abdollahi, Afsoun. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: afsoun_abdollahi@yahoo.com.
+ Mirzaei, Khadijeh. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: mirzaei_kh@tums.ac.ir.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ *Antioxidants/me [Metabolism]
+ *Basal Metabolism
+ Biomarkers/an [Analysis]
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ Male
+ Middle Aged
+ Obesity/me [Metabolism]
+ *Obesity/pp [Physiopathology]
+ Overweight/me [Metabolism]
+ *Overweight/pp [Physiopathology]
+ Prognosis
+ *Respiratory Physiological Phenomena
+ Young Adult
+Keyword Heading
+ Body composition
+ Body fat mass
+ Fat-free mass
+ Obesity
+ Overweight
+ Respiratory quotient
+ Resting metabolic rate
+ Total antioxidant capacity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ OBJECTIVE: The effect of total antioxidant capacity on resting metabolic rate (RMR) and respiratory quotient (RQ) of overweight and obese woman has been debated globally. Total Antioxidant Capacity may have an independent effect on resting metabolic rate and respiratory quotient.
+
+ METHODS AND MATERIALS: A study population of 263 aged 18-50 years participated in this cross-sectional study from the communities of Tehran based on cluster sampling. Dietary intake assessed by using a semi quantitative food frequency questionnaire (FFQ) Demographic questions. Anthropometrics measurements for each participant were done. Dietary total antioxidant capacity (DTAC) was calculated by the 147-item food frequency questionnaire (FFQ) and FRAP assay. Resting metabolic rate and respiratory quotient was measured by Indirect calorimetry.
+
+ RESULTS: The mean DTAC of the study participants was 1251.8 (SD 893.60). There was a statistically significant relationship between dietary total antioxidant capacity (DTAC) and respiratory quotient (P>0.013). People with high dietary total antioxidant capacity have tended to show a lower RQ than those with a lower one. There was a significant correlation between DTAC and RQ for both the adjusted model for age, total energy intake, BMI, physical activity, higher DTAC diet and the crude model which were (beta=0.011; SE=0.005; CI=-0.021_0) and (beta=-3.143E-6; SE=0; CI=0), respectively. However, we found no correlation between the DTAC and RMR/FFM-RES (P<0.49). Also, a significantly higher relationship was demonstrated between dietary total antioxidant capacity and intake vegetables (P<=0.006), fruits (P<=0.009), white meet (P<=0.03) and dairy products (P<=0.005).
+
+ CONCLUSION: RQ is correlated with total antioxidant capacity. Increased intake of high DTAC foods may result in weight loss maintenance. This result may suggest a beneficial role of higher-DTAC diets in the prevention of obesity. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Antioxidants). 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.07.030
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aghamohammadi&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=The+association+between+total+antioxidant+capacity+and+resting+metabolic+rate+%28RMR%29+%2F+respiratory+quotient+%28RQ%29+in+overweight+and+obese+woman.&volume=13&issue=4&spage=2763&epage=2767&date=2019&doi=10.1016%2Fj.dsx.2019.07.030&pmid=31405705&sid=OVID:medline
+
+<2069>
+Unique Identifier
+ 31405702
+Title
+ The most appropriate cut-off point of anthropometric indices in predicting the incidence of metabolic syndrome and its components.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2739-2745, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Farhangiyan Z; Latifi SM; Rashidi H; Shahbazian H
+Authors Full Name
+ Farhangiyan, Zahra; Latifi, Seyed Mahmoud; Rashidi, Homeira; Shahbazian, Hajieh.
+Institution
+ Farhangiyan, Zahra. Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Latifi, Seyed Mahmoud. Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+ Rashidi, Homeira. Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: hrashidi@ajums.ac.ir.
+ Shahbazian, Hajieh. Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
+MeSH Subject Headings
+ Adult
+ *Biomarkers/an [Analysis]
+ *Body Mass Index
+ Female
+ Follow-Up Studies
+ Humans
+ Incidence
+ Male
+ *Metabolic Syndrome/ep [Epidemiology]
+ *Obesity/pp [Physiopathology]
+ Prognosis
+ Prospective Studies
+ Risk Factors
+ *Waist Circumference
+ *Waist-Height Ratio
+ *Waist-Hip Ratio
+ Young Adult
+Keyword Heading
+ Anthropometric index
+ Components of metabolic syndrome
+ Metabolic syndrome
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ INTRODUCTION: The association of individuals' anthropometric indices with their development of metabolic syndrome (MetS) has been investigated in several studies. Taking into account the ethnic differences, this study aimed to determine the most appropriate cut-off points of anthropometric indices in predicting the incidence of MetS and its components in Ahvaz.
+
+ METHODS: This study is part of a cohort study conducted at the Diabetes Research Center of Ahvaz Jundishapur University of Medical Sciences on a population of over 20 in Ahvaz during 2009-2014. Of the 592 patients, 505 patients who were not diagnosed with MetS in 2009, were entered into this study. The data analyzed involved demographic information including age and sex, anthropometric information including height, weight, waist circumference (WC), hip circumference (HC) and the ratios between them, laboratory data including blood levels of Triglyceride (TG), Fasting plasma glucose (FPG) and High-density lipoprotein cholesterol (HDL-C), and clinical data including systolic(S) and diastolic(D)blood pressure(BP). After 5 years, the subjects were re-evaluated for MetS based on the National Cholesterol Education Program - Adult Treatment Panel III (NCEP-ATP III) criteria and the most appropriate cut-off points of anthropometric indices for the prediction of the incidence of MetS using the Receiver Operative Characteristic (ROC) curves were obtained.
+
+ RESULTS: Waist-to-Height Ratio (WHtR) index with a cut-off point of 0.53 followed by WC with a cut-off point of 87.5cm had the highest power to predict the incidence of MetS. The cut-off points of WC and Body mass index (BMI) were respectively 89.5cm and 26kg/m2 for men, and 83.5cm and 27.5kg/m2 for women. All anthropometric indices were able to predict the components of this syndrome (with the exception of low HDL-C). The cut-off point of WC in predicting High FBS, High TG and High BP was 84.5, 84.8, and 86.5cm, respectively.
+
+ CONCLUSION: Overall, it seems that given its ease of measurement, the WC index is preferred to other indices for predicting the incidence of MetS and its components in clinical screening. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.07.009
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Farhangiyan&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=The+most+appropriate+cut-off+point+of+anthropometric+indices+in+predicting+the+incidence+of+metabolic+syndrome+and+its+components.&volume=13&issue=4&spage=2739&epage=2745&date=2019&doi=10.1016%2Fj.dsx.2019.07.009&pmid=31405702&sid=OVID:medline
+
+<2070>
+Unique Identifier
+ 31405700
+Title
+ Dietary habits in association with general and abdominal obesity in central Iran: Results from Yazd Health Study (YaHS).
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2727-2732, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Ardekani MS; Salehi-Abargouei A; Mirzaei M; Fallahzadeh H; Nadjarzadeh A
+Authors Full Name
+ Ardekani, Maryam Saeida; Salehi-Abargouei, Amin; Mirzaei, Masoud; Fallahzadeh, Hossein; Nadjarzadeh, Azadeh.
+Institution
+ Ardekani, Maryam Saeida. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Salehi-Abargouei, Amin. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Mirzaei, Masoud. Yazd Cardiovascular Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Fallahzadeh, Hossein. Department of Biostatistics and Epidemiology, Research Center of Prevention and Epidemiology of Non-communicable Disease, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
+ Nadjarzadeh, Azadeh. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: azadnajarzadeh@ssu.ac.ir.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Biomarkers/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ *Diet/ae [Adverse Effects]
+ *Feeding Behavior
+ Female
+ Follow-Up Studies
+ Humans
+ Iran/ep [Epidemiology]
+ Male
+ Middle Aged
+ *Obesity/ep [Epidemiology]
+ Obesity/et [Etiology]
+ *Obesity, Abdominal/ep [Epidemiology]
+ Obesity, Abdominal/et [Etiology]
+ Prevalence
+ Prognosis
+ Risk Factors
+ *Waist Circumference
+ Young Adult
+Keyword Heading
+ Abdominal obesity
+ Adult
+ Dietary habits
+ Iran
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: Findings from few studies that investigated the relation between dietary habits and obesity are inconsistent so we aimed to assess the association between dietary habits with general and abdominal obesity in central Iran.
+
+ METHODS: This study has been conducted on 8652 adults aged 20-70 years participated in Yazd Health Study (YAHS). Data regarding dietary habits, socio-demographic characteristics and history of chronic illnesses were collected via questionnaire. Anthropometric parameters were measured using a scale and body analyzer. Odds ratio of obesity were assessed using a Binary Logistic Regression test.
+
+ RESULTS: Study participants consisted of 49.6% men and 50.4% women. The prevalence of general and abdominal obesity in this population was 25.9 and 45.3%, respectively. Our analysis revealed that subjects who drank carbonated drinks >=3 times/week had significantly higher odds of general and abdominal obesity compared to participants never did so (OR 1.89; 95%CI: 1.37-2.61, OR 1.11; 95%CI: 1.50-2.04) and those ate fast food more than 4 times a month had higher odds of abdominal obesity (OR 1.51; 95%CI: 1.12-2.03). The results also pointed that intake of low fat dairy products was inversely associated with general obesity (OR 0.79; 95% CI 0.63-0.98) and abdominal obesity (OR 0.66; 95% CI 0.54-0.82) when compared with full fat dairy products.
+
+ CONCLUSION: Carbonated drinks and fast food intake were positively associated with general/abdominal obesity, whereas low fat dairy products intake was inversely associated. Future cohort studies in this under-studied area are recommended. Copyright © 2018. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2018.11.040
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Ardekani&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Dietary+habits+in+association+with+general+and+abdominal+obesity+in+central+Iran%3A+Results+from+Yazd+Health+Study+%28YaHS%29.&volume=13&issue=4&spage=2727&epage=2732&date=2019&doi=10.1016%2Fj.dsx.2018.11.040&pmid=31405700&sid=OVID:medline
+
+<2071>
+Unique Identifier
+ 31405685
+Title
+ The complications of overweight and obesity according to obesity indicators (body mass index and waist circumference values) in a population of Tangier (northern Morocco): A cross-sectional study.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2619-2624, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hamjane N; Benyahya F; Mechita MB; Nourouti NG; Barakat A
+Authors Full Name
+ Hamjane, Nadia; Benyahya, Fatiha; Mechita, Mohcine Bennani; Nourouti, Naima Ghailani; Barakat, Amina.
+Institution
+ Hamjane, Nadia. Laboratory of Biomedical Genomics and Oncogenetics, Faculty of Sciences and Technology, Abdelmalek Essaadi University, Tangier, Morocco. Electronic address: hamjanenadia@gmail.com.
+ Benyahya, Fatiha. Pasteur Institute of Tangier, Morocco. Electronic address: benyahyafatiha@gmail.com.
+ Mechita, Mohcine Bennani. Laboratory of Biomedical Genomics and Oncogenetics, Faculty of Sciences and Technology, Abdelmalek Essaadi University, Tangier, Morocco. Electronic address: bennanimohcine@hotmail.com.
+ Nourouti, Naima Ghailani. Laboratory of Biomedical Genomics and Oncogenetics, Faculty of Sciences and Technology, Abdelmalek Essaadi University, Tangier, Morocco. Electronic address: nnghailani@gmail.com.
+ Barakat, Amina. Laboratory of Biomedical Genomics and Oncogenetics, Faculty of Sciences and Technology, Abdelmalek Essaadi University, Tangier, Morocco. Electronic address: barakatamina17@gmail.com.
+MeSH Subject Headings
+ Adiposity
+ Adult
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ *Cardiovascular Diseases/et [Etiology]
+ Cardiovascular Diseases/pa [Pathology]
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/et [Etiology]
+ Diabetes Mellitus, Type 2/pa [Pathology]
+ *Dyslipidemias/et [Etiology]
+ Dyslipidemias/pa [Pathology]
+ Female
+ Follow-Up Studies
+ Humans
+ *Hypertension/et [Etiology]
+ Hypertension/pa [Pathology]
+ Male
+ Middle Aged
+ Morocco
+ *Obesity/co [Complications]
+ *Overweight/co [Complications]
+ Prognosis
+ *Waist Circumference
+Keyword Heading
+ BMI
+ Metabolic complications
+ Obesity
+ WC
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: The aim of this work was to study overweight and obesity and their associated complications according to obesity indicators in a population of Tangier.
+
+ METHODS: A total of 480 overweight and obese patients were included in this study, referred to hospital Duc Tovar of Tangier during a period of 12 months. The collection of data has been done through a questionnaire which included anthropometric, clinical and biochemical characteristics of each patient. Statistical analyses included chi2 test, student's t-test, ANOVA, and multiple linear regression analyses.
+
+ RESULTS: The mean age of our patients was 45.56+/-12.23 years, the mean body mass index (BMI) was 33.97+/-5.84Kg/m2 and the average waist circumference (WC) was 109.78+/-15.42cm. Overweight affected 25.2% and obesity 74.8%, whose 88.8% of subjects had abdominal obesity. All the metabolic abnormalities were significantly associated with abdominal obesity (measured by WC). However, only total cholesterol (p=0.001) and triglycerides (p=0.000) were significantly associated with different classes of obesity (measured by BMI). The most common complications of obesity and overweight were: type 2 diabetes (56.8%), arterial hypertension (52%), dyslipidaemia (43.9%), and cardiovascular disease (CVD) (24.3%). Hypertension and hyperglycaemia were the major risk factors for developing CVD with OR=3.81 (95% CI:1.363-10.698; p<0.05) and OR=2.610 (95% CI:1.648-4.133; p<0.001) respectively.
+
+ CONCLUSION: Obesity exposes to several chronic complications, the most important in our study were type 2 diabetes and hypertension; these complications increased significantly with abdominal obesity that has constituted important risk factors of CVD. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.07.033
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hamjane&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=The+complications+of+overweight+and+obesity+according+to+obesity+indicators+%28body+mass+index+and+waist+circumference+values%29+in+a+population+of+Tangier+%28northern+Morocco%29%3A+A+cross-sectional+study.&volume=13&issue=4&spage=2619&epage=2624&date=2019&doi=10.1016%2Fj.dsx.2019.07.033&pmid=31405685&sid=OVID:medline
+
+<2072>
+Unique Identifier
+ 31405681
+Title
+ The gene expression of CTRP12 but not CTRP13 is upregulated in both visceral and subcutaneous adipose tissue of obese subjects.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2593-2599, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Omidifar A; Toolabi K; Rahimipour A; Emamgholipour S; Shanaki M
+Authors Full Name
+ Omidifar, Abolfazl; Toolabi, Karamollah; Rahimipour, Ali; Emamgholipour, Solaleh; Shanaki, Mehrnoosh.
+Institution
+ Omidifar, Abolfazl. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: a.shevidi@sbmu.ac.ir.
+ Toolabi, Karamollah. Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Tolabika@tums.ac.ir.
+ Rahimipour, Ali. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: a.rahimipour@sbmu.ac.ir.
+ Emamgholipour, Solaleh. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: semamgholipour@sina.tums.ac.ir.
+ Shanaki, Mehrnoosh. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: shanaki_m@sbmu.ac.ir.
+MeSH Subject Headings
+ *Adipokines/ge [Genetics]
+ Adolescent
+ Adult
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ *Complement C1q/ge [Genetics]
+ Female
+ Follow-Up Studies
+ *Gene Expression Regulation
+ Humans
+ Insulin Resistance
+ *Intra-Abdominal Fat/me [Metabolism]
+ Intra-Abdominal Fat/pp [Physiopathology]
+ Male
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ Obesity/pa [Pathology]
+ Prognosis
+ *Subcutaneous Fat/me [Metabolism]
+ Subcutaneous Fat/pp [Physiopathology]
+ Up-Regulation
+ Young Adult
+Keyword Heading
+ CTRP12
+ CTRP13
+ Inflammatory genes
+ Obese women
+ Obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Obesity is a well-known chronic low-grade inflammation condition characterized by dysregulated adipokine secretion and function. Both CTRP12 and CTRP13 are adipokines that influence glucose and lipid metabolism. We aimed to investigate CTRP12, CTRP13, and inflammatory gene expressions in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from obese women who underwent bariatric surgery in comparison with the normal weight women. This case-control study included 20 obese [body mass index (BMI)>35-40kg/m2] candidates for bariatric surgery and 20 normal-weight women (BMI <25kg/m2) as control group, who underwent elective surgeries. Real-time PCR was used to evaluate mRNA expression levels of CTRP12, CTRP13, and inflammatory genes in SAT and VAT from both groups. We observed significantly higher mRNA expression of CTRP12 in SAT (p=0.048) and VAT (p=0.046) from obese patients compared to the controls. There was significantly greater expression of IL-6 and MCP-1 inflammatory genes in SAT (p=0.013 and p=0.005 respectively) and VAT (p=0.000 and p=0.001 respectively) of obese patients compared to the control group. IL-1beta (p=0.015) and TNF-alpha (p=0.014) expressions significantly increased in VAT from obese patients compared to the control group. Spearman correlation analysis showed that CTRP12 expression significantly correlated with obesity indices. Our findings showed that CTRP12 significantly increased in both VAT and SAT of obese group. More importantly, we observed a positive correlation between CTRP12 with inflammatory parameters. These results indicated that CTRP12 might be part of an intricate network for glucose metabolism and obesity-related inflammation processes. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Adipokines). 0 (Biomarkers). 0 (C1QL3 protein, human). 0 (C1QTNF12 protein, human). 80295-33-6 (Complement C1q).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.07.027
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Omidifar&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=The+gene+expression+of+CTRP12+but+not+CTRP13+is+upregulated+in+both+visceral+and+subcutaneous+adipose+tissue+of+obese+subjects.&volume=13&issue=4&spage=2593&epage=2599&date=2019&doi=10.1016%2Fj.dsx.2019.07.027&pmid=31405681&sid=OVID:medline
+
+<2073>
+Unique Identifier
+ 31405666
+Title
+ Proof of concept: Effect of GLP-1 agonist on food hedonic responses and taste sensitivity in poor controlled type 2 diabetic patients.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2489-2494, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Brindisi MC; Brondel L; Meillon S; Barthet S; Grall S; Fenech C; Lienard F; Schlich P; Astruc K; Mouillot T; Jacquin-Piques A; Leloup C; Verges B; Penicaud L
+Authors Full Name
+ Brindisi, Marie-Claude; Brondel, Laurent; Meillon, Sophie; Barthet, Sophie; Grall, Sylvie; Fenech, Claire; Lienard, Fabienne; Schlich, Pascal; Astruc, Karine; Mouillot, Thomas; Jacquin-Piques, Agnes; Leloup, Corinne; Verges, Bruno; Penicaud, Luc.
+Institution
+ Brindisi, Marie-Claude. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; Diabetes and Endocrinology Unit, Dijon University Hospital, F-21000, France. Electronic address: marie-claude.brindisi@chu-dijon.fr.
+ Brondel, Laurent. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France.
+ Meillon, Sophie. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France.
+ Barthet, Sophie. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France.
+ Grall, Sylvie. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France.
+ Fenech, Claire. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France.
+ Lienard, Fabienne. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France.
+ Schlich, Pascal. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France.
+ Astruc, Karine. Epidemiology and Hospital Hygene Unit, France.
+ Mouillot, Thomas. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; Gastroenterology Department, Dijon University Hospital, F-21000, France.
+ Jacquin-Piques, Agnes. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; Neurology Department, Dijon University Hospital, F-21000, France.
+ Leloup, Corinne. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France.
+ Verges, Bruno. Diabetes and Endocrinology Unit, Dijon University Hospital, F-21000, France.
+ Penicaud, Luc. CNRS UMR 6265 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; INRA UMR 1324 Centre des Sciences du Gout et de l'Alimentation, F-21000, Dijon, France; Stromalab ERL 5311 CNRS, F-31432, Toulouse, France.
+MeSH Subject Headings
+ Adolescent
+ Adult
+ Aged
+ Aged, 80 and over
+ Biomarkers/an [Analysis]
+ Choice Behavior
+ *Diabetes Mellitus, Type 2/dt [Drug Therapy]
+ Diabetes Mellitus, Type 2/px [Psychology]
+ *Eating/px [Psychology]
+ *Feeding Behavior/px [Psychology]
+ Female
+ Follow-Up Studies
+ *Food Preferences/px [Psychology]
+ *Glucagon-Like Peptide 1/ag [Agonists]
+ Humans
+ Hunger/ph [Physiology]
+ Hypoglycemic Agents/tu [Therapeutic Use]
+ *Liraglutide/tu [Therapeutic Use]
+ Male
+ *Mental Recall
+ Middle Aged
+ Obesity/pc [Prevention & Control]
+ Prognosis
+ Taste/ph [Physiology]
+ Young Adult
+Keyword Heading
+ Diabetes
+ Food behavior
+ GLP1-Analogue
+ Taste perception
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: GLP-1 analogues decrease food intake and have great promise for the fight against obesity. Little is known about their effects on food hedonic sensations and taste perception in poor controlled patients with type 2 diabetes (T2D).
+
+ MATERIALS AND METHODS: Eighteen T2D patients with BMI >=25kg/m2 and poor controlled glycemia were studied before and after 3 months of treatment with Liraglutide. Detection thresholds for salty, sweet and bitter tastes, optimal preferences, olfactory liking, wanting and recalled liking for several food items were assessed. Subjects also answered questionnaires to measure their attitudes to food.
+
+ RESULTS: T2D patients had a significant decrease in bodyweight and HbA1c after treatment with Liraglutide. Liraglutide improved gustative detection threshold of sweet flavors, and decreased wanting for sweet foods and recalled liking for fatty foods. It also led to a decrease in feelings of hunger.
+
+ CONCLUSIONS: Liraglutide increases sensitivity to sweet tastes and decreases pleasure responses for fatty foods in poor controlled T2D patients, and is of particular interest in the understanding of the mechanisms of weight loss.
+
+ CLINICAL TRIAL: NCT02674893. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Hypoglycemic Agents). 839I73S42A (Liraglutide). 89750-14-1 (Glucagon-Like Peptide 1).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.06.021
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Brindisi&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Proof+of+concept%3A+Effect+of+GLP-1+agonist+on+food+hedonic+responses+and+taste+sensitivity+in+poor+controlled+type+2+diabetic+patients.&volume=13&issue=4&spage=2489&epage=2494&date=2019&doi=10.1016%2Fj.dsx.2019.06.021&pmid=31405666&sid=OVID:medline
+
+<2074>
+Unique Identifier
+ 31405659
+Title
+ The association of the common fat mass and obesity associated gene polymorphisms with type 2 diabetes in obese Iraqi population.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2451-2455, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Nasser FA; Algenabi AA; Hadi NR; Hussein MK; Fatima G; Al-Aubaidy HA
+Authors Full Name
+ Nasser, Fadhil A; Algenabi, Abdulhussein A; Hadi, Najah R; Hussein, Majid K; Fatima, Ghizal; Al-Aubaidy, Hayder A.
+Institution
+ Nasser, Fadhil A. Department of Clinical Biochemistry, College of Medicine, Kufa University, Najaf, Iraq.
+ Algenabi, Abdulhussein A. Department of Clinical Biochemistry, College of Medicine, Kufa University, Najaf, Iraq.
+ Hadi, Najah R. Department of Pharmacology, College of Medicine, Kufa University, Najaf, Iraq.
+ Hussein, Majid K. Department of Clinical Biochemistry, College of Medicine, Kufa University, Najaf, Iraq.
+ Fatima, Ghizal. Department of Biochemistry, Era's Medical College & Hospital, Lucknow, India.
+ Al-Aubaidy, Hayder A. School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora, VIC, 3086, Australia. Electronic address: H.Alaubaidy@latrobe.edu.au.
+MeSH Subject Headings
+ Adult
+ Aged
+ *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/ge [Genetics]
+ *Biomarkers/an [Analysis]
+ Body Mass Index
+ Case-Control Studies
+ *Diabetes Mellitus, Type 2/ep [Epidemiology]
+ *Diabetes Mellitus, Type 2/ge [Genetics]
+ Female
+ Follow-Up Studies
+ Gene Frequency
+ *Genetic Predisposition to Disease
+ Genotype
+ Humans
+ Insulin Resistance
+ Iraq
+ Male
+ Middle Aged
+ *Obesity/co [Complications]
+ *Polymorphism, Single Nucleotide
+ Prognosis
+Keyword Heading
+ Body mass index
+ Fat mass and obesity associated gene
+ Type 2 diabetes mellitus
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND & OBJECTIVES: This study investigates the association of two potential Fat mass and obesity associated gene (FTO) gene polymorphisms (rs9939609 and rs918031) as potential predictors of type 2 diabetes (T2D) in obese Iraqi population and their metabolic effects on hyperglycemia and insulin sensitivity.
+
+ MATERIALS & METHODS: The study included 400 participants with obesity & T2D, with a matching 400 obese non-diabetic cohort. Venous blood samples were collected for DNA extraction. Using specific primers and restriction enzymes, genotyping was performed to identify the various alleles for each gene. The genotype and allele frequencies determined by multinomial logistic regression analysis for FTO single nucleotide polymorphisms (rs9939609) among all the study groups.
+
+ RESULTS: There is a two-fold increase in the risk of T2D within the homozygous genotype (TT) group (OR=2.43, CI 95% 3.57-11.2, P<=0.001) as compared to the wild type (TA). In addition, there was a significantly higher level of the minor allele genotype (T) in T2D patients when compared to the control group, (P<=0.001).
+
+ CONCLUSION: We conclude that the FTO rs9939609 genotype significantly affect the development of insulin resistance, therefore the future occurrence of T2D, in obese individuals. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers). EC 1-14-11-33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO). EC 1-14-11-33 (FTO protein, human).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.06.024
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Nasser&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=The+association+of+the+common+fat+mass+and+obesity+associated+gene+polymorphisms+with+type+2+diabetes+in+obese+Iraqi+population.&volume=13&issue=4&spage=2451&epage=2455&date=2019&doi=10.1016%2Fj.dsx.2019.06.024&pmid=31405659&sid=OVID:medline
+
+<2075>
+Unique Identifier
+ 31405653
+Title
+ Variations in the pattern and distribution of non-obese components of metabolic syndrome across different obesity phenotypes among Iranian adults' population.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2419-2424, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Hajian-Tilaki K; Heidari B
+Authors Full Name
+ Hajian-Tilaki, Karimollah; Heidari, Behzad.
+Institution
+ Hajian-Tilaki, Karimollah. Dept of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran. Electronic address: drhajian@yahoo.com.
+ Heidari, Behzad. Dept of Internal Medicine, Ayatollah Rohani Hospital, Babol University of Medical Sciences, Iran.
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers/an [Analysis]
+ Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Hypertension/pp [Physiopathology]
+ Iran/ep [Epidemiology]
+ Male
+ *Metabolic Syndrome/ep [Epidemiology]
+ Middle Aged
+ *Obesity/cl [Classification]
+ *Obesity/pp [Physiopathology]
+ *Overweight/pp [Physiopathology]
+ Phenotype
+ Prognosis
+Keyword Heading
+ Central obese
+ Metabolic abnormality
+ Obesity phenotypes
+ Overweight/obese
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIMS: To investigate the association of obesity phenotypes with non-obese components of metabolic syndrome (MetS) by considering the presence of general adiposity and central obesity.
+
+ METHODS: We analyzed the data of population-based cross-sectional study of 981 adults' individuals who were community dwelling in urban population of Babol, the north of Iran. The demographic characteristics and anthropometric measures and hypertension were collected with standard method by trained nurses. The fasting blood sugar, CHL, TG, HDL-C and LDL-C were measured by enzymatic method. The presence of cardiometabolic risk factors were analyzed according to the combination of obesity phenotypes either overweight/obese or central obese. The logistic regression model was used to calculate the adjusted odds ratio (OR) of obesity phenotypes in compared with normal weight not central obese in association of presence of metabolic abnormality.
+
+ RESULTS: The 394 (40.6%) individuals were both overweight/obese and central obese and 295 (30.1%) persons were "normal weight not central obese" and the minority 28(2.9%) were normal weight but central obese and the remainder 260 (26.5%) were "overweight/obese not central obese". Overweight/obese not central obese increased significantly the odds of presence of >=2 non-obese components of metabolic abnormality by 2.17 times (95%CI OR: 1.51, 3.13) but the OR was elevated for the joint phenotypes of overweight/obese and central obese (OR=4.16 (95%CI: 2.85, 6.06) as compare with normal weight not central obese.
+
+ CONCLUSIONS: Overweight/obese alone increased the risk of cardiometabolic abnormality but being overweight/obese and central obese a further elevated the risk compared with "normal weight not central obese". Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.06.003
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Hajian-Tilaki&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Variations+in+the+pattern+and+distribution+of+non-obese+components+of+metabolic+syndrome+across+different+obesity+phenotypes+among+Iranian+adults%27+population.&volume=13&issue=4&spage=2419&epage=2424&date=2019&doi=10.1016%2Fj.dsx.2019.06.003&pmid=31405653&sid=OVID:medline
+
+<2076>
+Unique Identifier
+ 31405652
+Title
+ An update on metabolic syndrome: Metabolic risk markers and adipokines in the development of metabolic syndrome. [Review]
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2409-2417, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Kumari R; Kumar S; Kant R
+Authors Full Name
+ Kumari, Reena; Kumar, Sandeep; Kant, Ravi.
+Institution
+ Kumari, Reena. Department of Biochemistry, King George's Medical University, Lucknow, India.
+ Kumar, Sandeep. Department of Molecular Biology AIIMS, Rishikesh, India. Electronic address: sschaudhary55@gmail.com.
+ Kant, Ravi. Department of Molecular Biology AIIMS, Rishikesh, India.
+MeSH Subject Headings
+ *Adiponectin/me [Metabolism]
+ *Adiposity
+ *Biomarkers/me [Metabolism]
+ Humans
+ *Inflammation/co [Complications]
+ *Insulin Resistance
+ *Metabolic Syndrome/et [Etiology]
+ Metabolic Syndrome/me [Metabolism]
+ Metabolic Syndrome/pa [Pathology]
+ *Obesity/co [Complications]
+Keyword Heading
+ Adipokine
+ Dyslipidemia
+ Pathophysiology
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Metabolic syndrome is a collection of physiological and biochemical abnormalities about 20-25% of adult population in developing countries is suffering from metabolic syndrome. Previous research demonstrated that adipose tissue plays an important role in energy regulation via endocrine, paracrine and autocrine signals as results of obesity due to accumulation of adipose tissue to excess that by time affects negatively both physical and psychological health and well being, it has been found that adipose tissues produces a variety of factors known as "adipokines" which play a key role in the development and progression of the disease and also hypothesized that adipokines are a possible link between obesity and the other risk components of the Metabolic syndrome. Many of the adipokines exert multiple actions in a variety of cellular processes leading to a complex array of abnormal characteristic of Metabolic syndrome. Abnormal production of these adipokines by expanded visceral fat during Adiposity contributes to a pro-inflammatory state. Increasing evidence suggests that aberrant production/release of adipokine from adipocyte i.e. adiponectin, leptin and resistin etc, may contribute to the health problems associated with Adiposity such as dyslipidemia, insulin resistance and atherosclerosis. This study conclusively have shown a significant role of adipokines secreted by adipose tissue and various metabolic risk markers play a important role in the development of Metabolic syndrome. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Biomarkers).
+Publication Type
+ Journal Article. Review.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.06.005
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Kumari&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=An+update+on+metabolic+syndrome%3A+Metabolic+risk+markers+and+adipokines+in+the+development+of+metabolic+syndrome.&volume=13&issue=4&spage=2409&epage=2417&date=2019&doi=10.1016%2Fj.dsx.2019.06.005&pmid=31405652&sid=OVID:medline
+
+<2077>
+Unique Identifier
+ 31405647
+Title
+ The association of LRP5 (rs556442) polymorphism with body composition and obesity in postmenopausal women.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2381-2385, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Adabi E; Omidfar A; Farahani NA; Faghihi F; Asghar Malek Hosseini SA; Maghbooli Z; Shirvani A
+Authors Full Name
+ Adabi, Elham; Omidfar, Abolfazl; Farahani, Najmeh Afshari; Faghihi, Fatemeh; Asghar Malek Hosseini, Seyed Ali; Maghbooli, Zhila; Shirvani, Arash.
+Institution
+ Adabi, Elham. Tehran University of Medical Sciences, Tehran, Iran.
+ Omidfar, Abolfazl. Student Research Committee, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
+ Farahani, Najmeh Afshari. Islamic Azad University, Ashkezar Branch, Yazd, Iran.
+ Faghihi, Fatemeh. Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
+ Asghar Malek Hosseini, Seyed Ali. Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran.
+ Maghbooli, Zhila. Multiple Sclerosis Research Center, Neurosciences Institute of Tehran University of Medical Sciences, Tehran, Iran. Electronic address: z-maghbooli@sina.tums.ac.ir.
+ Shirvani, Arash. Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA. Electronic address: hn@bu.edu.
+MeSH Subject Headings
+ Biomarkers/an [Analysis]
+ *Body Composition
+ Body Mass Index
+ Case-Control Studies
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Genetic Predisposition to Disease
+ Genotype
+ Humans
+ Iran/ep [Epidemiology]
+ *Low Density Lipoprotein Receptor-Related Protein-5/ge [Genetics]
+ Middle Aged
+ Obesity/ep [Epidemiology]
+ *Obesity/ge [Genetics]
+ *Polymorphism, Single Nucleotide
+ *Postmenopause
+ Prognosis
+Keyword Heading
+ LRP5
+ Obesity
+ Postmenopausal women
+ rs566442
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ AIM: The main of this study was to investigate the association between the rs566442 (V1119V) coding polymorphism of Low-density lipoprotein receptor-related protein 5 (LRP5) with obesity and basal metabolic rate in Iranian postmenopausal women.
+
+ METHODS: This cross-sectional study was performed on 350 postmenopausal women with a mean age of 57.8 years (SD+/-6.14). Body composition was analyzed by bioelectrical impedance analysis (BIA) resistance. Obesity was defined based on Body mass index (BMI) >=30kg/m2. To determine the genotype of SNP (rs556442), PCR-RFLP assay was performed and confirmed by sequencing. DNA samples from participants were genotyped using the RFLP-PCR method.
+
+ RESULTS: Among the study population 37.1% (130) were obese. G allele had minor-allele frequency of 0.38% in our population. The frequency of genotypes in our study population was 12.9% (45 person) GG, 35.7% (125 person) AA and 51.4% (180) GA. After adjusting age and menopausal age, only basal metabolic rate showed significantly higher in GG group compare to other groups (p=0.02). Our data showed basal metabolic rate was higher in obese women with GG genotype in comparison to obese women with AG and AA genotypes.
+
+ DISCUSSION: The findings of this study suggest that the GG genotype of SNP (rs556442) could protective role in obese women through the association with BMR. Copyright © 2019. Published by Elsevier Ltd.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (LRP5 protein, human). 0 (Low Density Lipoprotein Receptor-Related Protein-5).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.06.004
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Adabi&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=The+association+of+LRP5+%28rs556442%29+polymorphism+with+body+composition+and+obesity+in+postmenopausal+women.&volume=13&issue=4&spage=2381&epage=2385&date=2019&doi=10.1016%2Fj.dsx.2019.06.004&pmid=31405647&sid=OVID:medline
+
+<2078>
+Unique Identifier
+ 31405639
+Title
+ Association between hypertension and adiposity indicators: A study among the Muslim population of Uttar Pradesh.
+Source
+ Diabetes & Metabolic Syndrome. 13(4):2335-2338, 2019 Jul - Aug.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Tselha N; Shimrah C; Kulshreshtha M; Devi NK
+Authors Full Name
+ Tselha, Ngawang; Shimrah, Chonsing; Kulshreshtha, Monika; Devi, Naorem Kiranmala.
+Institution
+ Tselha, Ngawang. Department of Anthropology University of Delhi, Delhi, 110007, India.
+ Shimrah, Chonsing. Department of Anthropology University of Delhi, Delhi, 110007, India.
+ Kulshreshtha, Monika. Department of Anthropology University of Delhi, Delhi, 110007, India.
+ Devi, Naorem Kiranmala. Department of Anthropology University of Delhi, Delhi, 110007, India. Electronic address: kmaladevi@gmail.com.
+Comments
+ Erratum in (EIN)
+MeSH Subject Headings
+ *Adiposity
+ Adult
+ Biomarkers/an [Analysis]
+ *Body Mass Index
+ Cross-Sectional Studies
+ Female
+ Follow-Up Studies
+ Humans
+ *Hypertension/ep [Epidemiology]
+ India/ep [Epidemiology]
+ *Islam
+ Male
+ *Obesity/pp [Physiopathology]
+ Prevalence
+ Prognosis
+ Risk Factors
+ *Waist Circumference
+ *Waist-Hip Ratio
+Keyword Heading
+ Adiposity
+ Hypertension
+ Muslim
+ Percent body fat
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ BACKGROUND: Hypertension and obesity have become a global issue and an important public health concern due to an unhealthy lifestyle. The present study aims to determine the prevalence of hypertension and its association with various adiposity indicators among Sunni Muslim population of Lucknow, Uttar Pradesh.
+
+ MATERIALS AND METHODS: A cross-sectional study was conducted among 214 individuals using purposive sampling method. Somatometric measurements were taken using the ISAK protocol. Correlation analysis and odds ratio were calculated to determine the best predictor of hypertension.
+
+ RESULTS: 41% of males and 42.1% of females were found to be in Stage-II hypertension. BMI and WC were found to have the highest correlation with SBP among males and females, respectively. WHR followed by WC and BMI, was found to be the strongest predictor of hypertension in males. In the case of females, WHtR Followed by, BMI and WHR were found to be the strongest predictors of hypertension.
+
+ CONCLUSION: Among the presently studied Muslim population of Lucknow, a high prevalence of hypertension was found among both males and females. Also, WHR among males and WC among females were found to be better predictors of hypertension. Thus, for better prediction of risk of hypertension, sex and ethnicity-specific adiposity indicator should be used in clinical practice. Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
+Registry Number/Name of Substance
+ 0 (Biomarkers).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1016%2fj.dsx.2019.05.016
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Tselha&issn=1871-4021&title=Diabetes+%26+Metabolic+Syndrome&atitle=Association+between+hypertension+and+adiposity+indicators%3A+A+study+among+the+Muslim+population+of+Uttar+Pradesh.&volume=13&issue=4&spage=2335&epage=2338&date=2019&doi=10.1016%2Fj.dsx.2019.05.016&pmid=31405639&sid=OVID:medline
+
+<2079>
+Unique Identifier
+ 31405086
+Title
+ Effects of Telephone Follow-Up Intervention on %Body Fat, Inflammatory Cytokines, and Oxidative Stress in Obese Hispanic Children.
+Source
+ International Journal of Environmental Research & Public Health [Electronic Resource]. 16(16), 2019 08 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Rhyu HS; Park KS
+Author NameID
+ Rhyu, Hyun-Seung; ORCID: https://orcid.org/0000-0002-4987-7482
+ Park, Kyung-Shin; ORCID: https://orcid.org/0000-0002-0761-4502
+Authors Full Name
+ Rhyu, Hyun-Seung; Park, Kyung-Shin.
+Institution
+ Rhyu, Hyun-Seung. Major of Sports Coaching, Department of Physical Education, Jungwon University, Chungbuck 28024, Korea.
+ Park, Kyung-Shin. College of Nursing and Health Sciences, Texas A&M International University, Laredo, TX 78041, USA. kpark@tamiu.edu.
+MeSH Subject Headings
+ Adiponectin/me [Metabolism]
+ Adolescent
+ Anthropometry
+ Antioxidants/me [Metabolism]
+ Biomarkers/me [Metabolism]
+ *Body Mass Index
+ C-Reactive Protein/me [Metabolism]
+ Child
+ *Cytokines/me [Metabolism]
+ Female
+ Follow-Up Studies
+ *Hispanic or Latino
+ Humans
+ Inflammation/bl [Blood]
+ *Inflammation Mediators/me [Metabolism]
+ Interleukin-6/bl [Blood]
+ Male
+ *Obesity/me [Metabolism]
+ *Oxidative Stress
+ Telephone
+Keyword Heading
+ Hispanic children
+ follow-up intervention
+ inflammatory cytokines
+ obesity
+ oxidative stress
+ summer camp
+ telephone intervention
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ This study investigated whether 10 month telephone follow-up intervention effectively stabilizes reductions in %body fat, and markers of inflammation and oxidative stress obtained from summer camp in obese Hispanic children. Fifty-six obese children (19 SUTI: summer camp and 10 months of follow-up telephone intervention, 18 SU: summer camp intervention only, and 19 CON: no intervention) completed this study. Anthropometric data and blood samples were obtained before (PRE), after 8 weeks of summer camp, and a 10month follow-up telephone intervention to measure markers of inflammation and oxidative stress. Eight weeks of summer camp significantly reduced %body fat, and levels of tumor necrosis factor-alpha, C-reactive protein and 8-hydroxydeoxyguanosine. It also elevated levels of adiponectin and total antioxidant status in SUTI and SU (p < 0.05). However, results of the 10month follow-up measurement were reverted back to PRE in SU, whereas the results for SUTI remained different to PRE (p < 0.05). Results confirm that levels of inflammation and oxidative stress are correlated to changes in %body fat, indicating that fat loss is effective in preventing and managing obesity-associated disorders. It is suggested that a telephone intervention is an effective follow-up tool for stabilizing reductions in %body fat as well as levels of inflammation and oxidative stress that were obtained from an intensive summer camp program in obese Hispanic children.
+Registry Number/Name of Substance
+ 0 (ADIPOQ protein, human). 0 (Adiponectin). 0 (Antioxidants). 0 (Biomarkers). 0 (Cytokines). 0 (Inflammation Mediators). 0 (Interleukin-6). 9007-41-4 (C-Reactive Protein).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fijerph16162854
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Rhyu&issn=1660-4601&title=International+Journal+of+Environmental+Research+%26+Public+Health+%5BElectronic+Resource%5D&atitle=Effects+of+Telephone+Follow-Up+Intervention+on+%25Body+Fat%2C+Inflammatory+Cytokines%2C+and+Oxidative+Stress+in+Obese+Hispanic+Children.&volume=16&issue=16&spage=&epage=&date=2019&doi=10.3390%2Fijerph16162854&pmid=31405086&sid=OVID:medline
+
+<2080>
+Unique Identifier
+ 31398142
+Title
+ Serum level of insulin-like growth factor-I in type 2 diabetic patients: impact of obesity.
+Source
+ Hormone Molecular Biology & Clinical Investigation. 39(1), 2019 Aug 09.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Aleidi SM; Shayeb E; Bzour J; Abu-Rish EY; Hudaib M; Al Alawi S; Bustanji Y
+Author NameID
+ Aleidi, Shereen M; ORCID: https://orcid.org/0000-0001-9222-464X
+ Bustanji, Yasser; ORCID: https://orcid.org/0000-0003-1315-0609
+Authors Full Name
+ Aleidi, Shereen M; Shayeb, Eman; Bzour, Jameel; Abu-Rish, Eman Y; Hudaib, Mohammad; Al Alawi, Sundus; Bustanji, Yasser.
+Institution
+ Aleidi, Shereen M. The University of Jordan, Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, 11942Amman, Jordan.
+ Shayeb, Eman. The University of Jordan, Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, 11942Amman, Jordan.
+ Bzour, Jameel. Al-Balqa Applied University, Salt, Jordan.
+ Abu-Rish, Eman Y. The University of Jordan, Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, 11942Amman, Jordan.
+ Hudaib, Mohammad. Al Ain University of Science and Technology, Collage of pharmacy, 112612,Abu Dhabi, UAE.
+ Hudaib, Mohammad. The University of Jordan, pharmaceutical science,school of pharmacy, Amman, Jordan.
+ Al Alawi, Sundus. The University of Jordan, Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, 11942Amman, Jordan.
+ Bustanji, Yasser. The University of Jordan, Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, 11942Amman, Jordan.
+ Bustanji, Yasser. Hamdi Mango Center for Scientific Research, Amman, Jordan.
+MeSH Subject Headings
+ Biomarkers
+ Blood Glucose
+ Body Mass Index
+ Cross-Sectional Studies
+ *Diabetes Mellitus, Type 2/bl [Blood]
+ Diabetes Mellitus, Type 2/di [Diagnosis]
+ Female
+ Humans
+ *Insulin-Like Growth Factor I
+ Male
+ Middle Aged
+ Obesity/et [Etiology]
+ Obesity/me [Metabolism]
+ Prevalence
+Keyword Heading
+ diabetes mellitus
+ gender
+ insulin-like growth factor-I
+ obesity
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Background Insulin-like growth factor-I (IGF-I) is homologous to proinsulin and possesses glucose reducing activity. The association between the level of IGF-I and diabetes has been highlighted. However, this association is controversial due to the influence of different factors including obesity. The aim of the study was to evaluate serum level of IGF-I in type 2 diabetic patients compared to control subjects. Materials and methods A cross-sectional study involving 100 participants was conducted. Serum levels of IGF-I were measured using enzyme-linked immunosorbent assay (ELISA) and the fasting plasma glucose (FPG) levels were measured using the glucose oxidase method. Results IGF-I levels in the diabetic patients were significantly lower than in non-diabetic control subjects (105.13 +/- 6.34 vs. 159.96 +/- 9.62 ng/mL, p < 0.0001). Among the diabetic group, there was no significant difference in IGF-I levels between obese diabetic patients and non-obese diabetic patients, p = 0.18. Similarly, among the non-diabetic group, a non-significant difference was found in IGF-I levels between obese non-diabetic and non-obese non-diabetic subjects, p = 0.156. However, among the obese group, obese diabetic patients had significantly lower IGF-I serum levels compared to obese non-diabetic subjects (112.07 +/- 7.97 vs. 147.07 +/- 13.05 ng/mL, p = 0.02). Furthermore, among the non-obese group, the non-obese diabetic patients had significantly lower IGF-I serum levels compared to the non-obese non-diabetic subjects (91.66 +/- 9.93 vs. 171.86 +/- 13.86 ng/mL, p < 0.0001). No significant associations were observed between IGF-I level and any of the age, gender, body mass index (BMI), FPG levels, or the duration of diabetes. Conclusions Type 2 diabetes mellitus is associated with lower levels of IGF-I regardless to the presence or absence of obesity.
+Registry Number/Name of Substance
+ 0 (Biomarkers). 0 (Blood Glucose). 0 (IGF1 protein, human). 67763-96-6 (Insulin-Like Growth Factor I).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1515%2fhmbci-2019-0015
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Aleidi&issn=1868-1883&title=Hormone+Molecular+Biology+%26+Clinical+Investigation&atitle=Serum+level+of+insulin-like+growth+factor-I+in+type+2+diabetic+patients%3A+impact+of+obesity.&volume=39&issue=1&spage=&epage=&date=2019&doi=10.1515%2Fhmbci-2019-0015&pmid=31398142&sid=OVID:medline
+
+<2081>
+Unique Identifier
+ 31397239
+Title
+ Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys.
+Source
+ British Journal of Nutrition. 122(3):262-273, 2019 08 14.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Drotningsvik A; Midttun O; Vikoren LA; McCann A; Ueland PM; Mellgren G; Gudbrandsen OA
+Author NameID
+ Gudbrandsen, Oddrun Anita; ORCID: https://orcid.org/0000-0001-5268-692X
+Authors Full Name
+ Drotningsvik, Aslaug; Midttun, Oivind; Vikoren, Linn Anja; McCann, Adrian; Ueland, Per Magne; Mellgren, Gunnar; Gudbrandsen, Oddrun Anita.
+Institution
+ Drotningsvik, Aslaug. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
+ Midttun, Oivind. Bevital AS, Jonas Lies veg 87, 5021 Bergen, Norway.
+ Vikoren, Linn Anja. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
+ Vikoren, Linn Anja. Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
+ McCann, Adrian. Bevital AS, Jonas Lies veg 87, 5021 Bergen, Norway.
+ Ueland, Per Magne. Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
+ Ueland, Per Magne. Laboratory of Clinical Biochemistry, Haukeland University Hospital, 5021 Bergen, Norway.
+ Mellgren, Gunnar. Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Haukeland University Hospital, 5021 Bergen, Norway.
+ Mellgren, Gunnar. Hormone Laboratory, Haukeland University Hospital, 5021 Bergen, Norway.
+ Gudbrandsen, Oddrun Anita. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
+MeSH Subject Headings
+ Amino Acids/bl [Blood]
+ Amino Acids/ur [Urine]
+ Animals
+ Biomarkers/bl [Blood]
+ Body Weight
+ Caseins/me [Metabolism]
+ *Diet
+ Dietary Proteins/ad [Administration & Dosage]
+ Fish Proteins/ad [Administration & Dosage]
+ Kidney/me [Metabolism]
+ *Kidney Diseases/bl [Blood]
+ Kidney Function Tests
+ Male
+ Obesity/me [Metabolism]
+ *Plasma/me [Metabolism]
+ Rats
+ Rats, Long-Evans
+ Rats, Zucker
+ Renal Insufficiency/bl [Blood]
+ Renal Insufficiency/ur [Urine]
+ *Salmon
+ Seafood
+ Species Specificity
+ *Vitamins/bl [Blood]
+ *Vitamins/ur [Urine]
+Keyword Heading
+ Amino acids
+ Kidney function
+ Long-Evans rats
+ Salmon
+ Zucker fa/fa rats
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Kidney function affects amino acid metabolism and vitamin status. The aims of the present study were to investigate urine and plasma concentrations of amino acids as well as plasma vitamin status in rats with impaired renal function (Zucker fa/fa rats) and in rats with normal kidney function (Long-Evans rats), and to explore the effects of salmon intake on these parameters and potential biomarkers of salmon intake in both rat strains. Male rats were fed diets with casein as sole protein source (control diet) or 25 % protein from baked salmon and 75 % casein for 4 weeks. Urine concentrations of markers of renal function and most amino acids and plasma concentrations of most vitamins were higher, and plasma concentrations of several amino acids including arginine, total glutathione and most tryptophan metabolites were lower in Zucker fa/fa rats compared with Long-Evans rats fed the control diet. Concentrations of kidney function markers were lower after salmon intake only in Zucker fa/fa rats. A trend towards lower urine concentrations of amino acids was seen in both rat strains fed the salmon diet, but this was more pronounced in Long-Evans rats and did not reflect the dietary amino acid content. Urine 1-methylhistidine, 3-methylhistidine, trimethylamineoxide and creatine concentrations, and plasma 1-methylhistidine and creatine concentrations were higher after salmon intake in both rat strains. To conclude, concentrations of amino acids in urine and plasma as well as vitamin status were different in Zucker fa/fa and Long-Evans rats, and the effects of salmon intake differed by rat strain for some of these parameters.
+Registry Number/Name of Substance
+ 0 (Amino Acids). 0 (Biomarkers). 0 (Caseins). 0 (Dietary Proteins). 0 (Fish Proteins). 0 (Vitamins).
+Publication Type
+ Journal Article. Research Support, Non-U.S. Gov't.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1017%2fS0007114519001284
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Drotningsvik&issn=0007-1145&title=British+Journal+of+Nutrition&atitle=Urine+and+plasma+concentrations+of+amino+acids+and+plasma+vitamin+status+differ%2C+and+are+differently+affected+by+salmon+intake%2C+in+obese+Zucker+fa%2Ffa+rats+with+impaired+kidney+function+and+in+Long-Evans+rats+with+healthy+kidneys.&volume=122&issue=3&spage=262&epage=273&date=2019&doi=10.1017%2FS0007114519001284&pmid=31397239&sid=OVID:medline
+
+<2082>
+Unique Identifier
+ 31394876
+Title
+ Oleacein Prevents High Fat Diet-Induced Adiposity and Ameliorates Some Biochemical Parameters of Insulin Sensitivity in Mice.
+Source
+ Nutrients. 11(8), 2019 08 07.
+VI 1
+Record Owner
+ From MEDLINE, a database of the U.S. National Library of Medicine.
+Status
+ MEDLINE
+Authors
+ Lepore SM; Maggisano V; Bulotta S; Mignogna C; Arcidiacono B; Procopio A; Brunetti A; Russo D; Celano M
+Authors Full Name
+ Lepore, Saverio Massimo; Maggisano, Valentina; Bulotta, Stefania; Mignogna, Chiara; Arcidiacono, Biagio; Procopio, Antonio; Brunetti, Antonio; Russo, Diego; Celano, Marilena.
+Institution
+ Lepore, Saverio Massimo. Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
+ Maggisano, Valentina. Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
+ Bulotta, Stefania. Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
+ Mignogna, Chiara. Interdepartmental Service Center, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
+ Arcidiacono, Biagio. Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
+ Procopio, Antonio. Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
+ Brunetti, Antonio. Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
+ Russo, Diego. Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy. d.russo@unicz.it.
+ Celano, Marilena. Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
+MeSH Subject Headings
+ 3T3-L1 Cells
+ Adipogenesis/de [Drug Effects]
+ Adipose Tissue/ch [Chemistry]
+ Adipose Tissue/de [Drug Effects]
+ *Adiposity/de [Drug Effects]
+ *Aldehydes/pd [Pharmacology]
+ Animals
+ Anti-Obesity Agents/pd [Pharmacology]
+ Biomarkers/an [Analysis]
+ *Diet, High-Fat
+ Glucose Transporter Type 4/an [Analysis]
+ *Insulin Resistance
+ Male
+ Mice
+ Mice, Inbred C57BL
+ Obesity/pc [Prevention & Control]
+ *Phenols/pd [Pharmacology]
+Keyword Heading
+ Glut-4
+ abdominal fat
+ adipogenesis
+ high-fat diet
+ obesity
+ oleacein
+Keyword Heading Owner
+ NOTNLM
+Abstract
+ Oleacein is one of the most abundant polyphenolic compounds of olive oil, which has been shown to play a protective role against several metabolic abnormalities, including dyslipidemia, insulin resistance, and glucose intolerance. Herein, we investigated the effects of oleacein on certain markers of adipogenesis and insulin-resistance in vitro, in 3T3-L1 adipocytes, and in vivo in high-fat diet (HFD)-fed mice. During the differentiation process of 3T3-L1 preadipocytes into adipocytes, oleacein strongly inhibited lipid accumulation, and decreased protein levels of peroxisome proliferator-activated receptor gamma (PPARgamma) and fatty acid synthase (FAS), while increasing Adiponectin levels. In vivo, treatment with oleacein of C57BL/6JOlaHsd mice fed with HFD for 5 and 13 weeks prevented the increase in adipocyte size and reduced the inflammatory infiltration of macrophages and lymphocytes in adipose tissue. These effects were accompanied by changes in the expression of adipose tissue-specific regulatory elements such as PPARgamma, FAS, sterol regulatory element-binding transcription factor-1 (SREBP-1), and Adiponectin, while the expression of insulin-sensitive muscle/fat glucose transporter Glut-4 was restored in HFD-fed mice treated with oleacein. Collectively, our findings indicate that protection against HFD-induced adiposity by oleacein in mice is mediated by the modulation of regulators of adipogenesis. Protection against HFD-induced obesity is effective in improving peripheral insulin sensitivity.
+Registry Number/Name of Substance
+ 0 (Aldehydes). 0 (Anti-Obesity Agents). 0 (Biomarkers). 0 (Glucose Transporter Type 4). 0 (Phenols). 0 (Slc2a4 protein, mouse). 0 (oleacein).
+Publication Type
+ Journal Article.
+Year of Publication
+ 2019
+Link to the Ovid Full Text or citation
+ https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.3390%2fnu11081829
+Link to the External Link Resolver
+ https://libkey.io/libraries/1108/openurl?genre=article&aulast=Lepore&issn=2072-6643&title=Nutrients&atitle=Oleacein+Prevents+High+Fat+Diet-Induced+Adiposity+and+Ameliorates+Some+Biochemical+Parameters+of+Insulin+Sensitivity+in+Mice.&volume=11&issue=8&spage=&epage=&date=2019&doi=10.3390%2Fnu11081829&pmid=31394876&sid=OVID:medline
+
+
+